Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice.

Science.gov (United States)

Suzuki, Yohei; Sato, Tadashi; Sugimoto, Masataka; Baskoro, Hario; Karasutani, Keiko; Mitsui, Aki; Nurwidya, Fariz; Arano, Naoko; Kodama, Yuzo; Hirano, Shin-Ichi; Ishigami, Akihito; Seyama, Kuniaki; Takahashi, Kazuhisa

2017-10-07

Chronic obstructive pulmonary disease (COPD) is predominantly a cigarette smoke (CS)-triggered disease with features of chronic systemic inflammation. Oxidants derived from CS can induce DNA damage and stress-induced premature cellular senescence in the respiratory system, which play significant roles in COPD. Therefore, antioxidants should provide benefits for the treatment of COPD; however, their therapeutic potential remains limited owing to the complexity of this disease. Recently, molecular hydrogen (H 2 ) has been reported as a preventive and therapeutic antioxidant. Molecular H 2 can selectively reduce hydroxyl radical accumulation with no known side effects, showing potential applications in managing oxidative stress, inflammation, apoptosis, and lipid metabolism. However, there have been no reports on the efficacy of molecular H 2 in COPD patients. In the present study, we used a mouse model of COPD to investigate whether CS-induced histological damage in the lungs could be attenuated by administration of molecular H 2 . We administered H 2 -rich pure water to senescence marker protein 30 knockout (SMP30-KO) mice exposed to CS for 8 weeks. Administration of H 2 -rich water attenuated the CS-induced lung damage in the SMP30-KO mice and reduced the mean linear intercept and destructive index of the lungs. Moreover, H 2 -rich water significantly restored the static lung compliance in the CS-exposed mice compared with that in the CS-exposed H 2 -untreated mice. Moreover, treatment with H 2 -rich water decreased the levels of oxidative DNA damage markers such as phosphorylated histone H2AX and 8-hydroxy-2'-deoxyguanosine, and senescence markers such as cyclin-dependent kinase inhibitor 2A, cyclin-dependent kinase inhibitor 1, and β-galactosidase in the CS-exposed mice. These results demonstrated that H 2 -rich pure water attenuated CS-induced emphysema in SMP30-KO mice by reducing CS-induced oxidative DNA damage and premature cell senescence in the lungs. Our

Acidez potencial pelo método do pH SMP no Estado do Amazonas Potential acidity by pH SMP method in Amazonas State, Brazil

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Adônis Moreira

2004-01-01

Full Text Available O objetivo deste trabalho foi definir um modelo matemático que estime o H+Al a partir do pH SMP medido em água e em solução de CaCl2 0,01 mol L-1 nas condições edafoclimáticas locais. Foram utilizadas 246 amostras de solo provenientes de diversas localidades. Mesmo apresentando menor coeficiente da correlação (r = 0,89*, a equação H+Al = 30,646 - 3,848pH SMP obtida em H2O foi mais eficiente que a obtida em solução CaCl2 (H+Al = 30,155 - 3,834pH SMP, r = 0,91*, a qual subestima os valores da acidez potencial.The objective of this work was to determine a mathematic model that estimates the potential acidity with pH SMP measured in water and in solution of CaCl2 0.01 mol L-1. Two hundred and forty six soil samples from several localities were utilized. Despite presenting a lower correlation coefficient (r = 0.89*, the equation H+Al = 30.646 - 3.848pH SMP, obtained in H2O, was more efficient than in the CaCl2 solution (H+Al = 30.155 -3.834pH SMP, r = 0.91*, since this last one underestimates the values of the potential acidity.

PENGEMBANGAN SOAL MATEMATIKA MODEL TIMSS UNTUK MENDUKUNG PEMBELAJARAN MATEMATIKA SMP KELAS VII KURIKULUM 2013

OpenAIRE

M. Andy Rudhito; D. Arif Budi Prasety

2016-01-01

Abstrak: Penelitian ini bertujuan untuk menghasilkan soal matematika model TIMSS yang valid dan praktis untuk siswa SMP berdasarkan Kurikulum 2013. Metode penelitian yang digunakan adalah penelitian pengembangan. Proses pendesainan soal sebagai instrumen penilaian dilakukan dengan prototyping. Prototyping meliputi dua tahap. Prototipe I merupakan hasil desain dan penyusunan soal-soal oleh peneliti sendiri, sedang prototipe II revisi dari prototipe I berdasarkan masukan dari pakar, teman sejaw...

PENGELOLAAN BANTUAN SISWA MISKIN DI SMP MUHAMMADIYAH 8 WONOGIRI

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Heru Mahmudi Santoso

2015-08-01

Full Text Available The aims of the research are to: 1 describe the preparation of management of Student Financial Aid Program; 2 describe the activities of management of Student Financial Aid Program; and 3 describe the management report of Student Financial Aid Program at SMP Muhammadiyah 8 Wonogiri. The research method applied was descriptive qualitative study by using an ethnographic approach. The subject of the research was SMP Muhammadiyah 8 Wonogiri. The data were collected through in-deep interview, observation and documentation. The informants of the research are: the principal, vice-principal, and teachers, who have the role in Poverty Student Aids management of SMP Muhammadiyah 8 Wonogiri. The data were obtained and analyzed by using an interactive model which included data collection, reduction, verification and drawing conclusion. The research result showed that; 1 The preparation of management of Student Financial Aid Program at SMP Muhammadiyah 8 Wonogiri was started by conducting a coordination among the principal, teachers, staffs, and team. Then they prepared some data related to students’ background which would be promoted to get Student Financial Aid Program ; 2 The activities in managing of The Student Financial Aid Program was started by planning, actuating, distributing, recording, controlling, and reporting of Student Financial Aid Program as a form of responsibility of the team in managing Student Financial Aid Program, and 3 In the end of management process of Student Financial Aid Program, school or the team had a responsibility to record and report the outcome of the management of Student Financial Aid Program at SMP Muhammadiyah 8 Wonogiri. By reporting the outcome, it meant that the management of Student Financial Aid Program had been finished. The whole management activities of Student Financial Aid Program were based on the principles of School Financial Management, those are; transparency, accountability, effectively, efficiency

Tingkat Adaptasi Kepemimpinan Kepala Sekolah Menghadapi Situasi dalam Pengambilan Keputusan Strategik: Studi di SMP Kota Semarang 2005

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Arief Yulianto

2011-06-01

Full Text Available Penelitian ini bertujuan mengatahui karakteristik kepemimpinan Kepala SMP dalam melakukan adaptasi dengan lingkungan kerja dan Mengetahui peran serta yang diberikan seluruh anggota sekolah dalam pengambilan keputusan strategis kepada Kepala SMP.Sasaran studi ini dipilih berdasarkan teknik representative purposive sampling, yaitu  sebanyak 16 SMP di kota Semarang serta dengan purposive (syarat yaitu telah menerapkan MBS . Model analisis data yang dilakukan adalah dengan menggunakan model LASI (Leadership Adaptability and Style Inventory. Pembahasan Analisis Situasional. Pada pembahasan ini adalah mengenai deskripsi gaya kepemimpinan Kepala SMP terkait dengan lingkungan yang ada di lingkungannya. Indikator pada gaya kepemimpinan ini adalah tingkat penyelesaian pekerjaan (perilaku tugas serta hubungan personal dan organisasi (interaksional baik secara individu maupun kelompok. Dari hasil data primer yang didapat, sesuai dengan 12 situasi dalam variabel LASI. Pembahasan Analisis Situasiona .Pada pembahasan ini adalah mengenai deskripsi gaya kepemimpinan Kepala SMP terkait dengan lingkungan yang ada di lingkungannya. Indikator pada gaya kepemimpinan ini adalah tingkat penyelesaian pekerjaan (perilaku tugas serta hubungan personal dan organisasi (interaksional baik secara individu maupun kelompok. Dari hasil data primer yang didapat, sesuai dengan 12 situasi dalam variabel LASI maka dapat diinterpresikan sebagai berikut Kata Kunci: Kepemimpinan Adaptif, Model LASI,MBS

ANALISIS KUALITAS PENGELOLAAN KELAS PEMBELAJARAN SAINS PADA SMP SSN DI KABUPATEN PATI

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Prasetyaningsih Prasetyaningsih

2016-12-01

Full Text Available Abstract This study aimed at identifying in: (1 planning the classroom management for the SSN classes and (2 managing the classroom, in the teaching and learning process of science in SSN schools.This is a evaluatif study which focuses on the classroom management of science learning in SSN junior high schools. The subjects of the research are SSN Junior High Schools of Pati Regency which focuses on the classroom management of science learning. There are six SSN schools, namely  SMP N 2 Pati, SMP N 4 Pati,  SMP N 1 Wedarijaksa, SMP N 1 Trangkil, SMP N 1 Tlogowungu, and SMP N 1 Gabus. The data were gained through observation, interview, questionnaire, and document study.The result shows that : the classroom management planning  in SSN Junior High Schools in the science learning at Pati Regency are categorizes good: the science teacher  SSN Junior High School the use of ICT in science learning was not taken into account, teaching materials (handouts, worksheets, modules and ICT-based teaching material were not developed yet, the assessment planning did not complete. Process in the science learning at SNN junior High School are as categirizes good.  Keywords: Classroom Management, SSN, Science Learning. Abstrak Penelitian ini bertujuan untuk: (1 mengidentifikasi perencanaan pengelolaan kelas di SMP SSN dalam pembelajaran sains; (2 mengidentifikasi proses pengelolaan kelas di SMP SSN dalam pembelajaran sains. Penelitian ini merupakan penelitian evaluatif, yang memfokuskan pada kualitas pengelolaan kelas pembelajaran sains pada SMP SSN. Subjek penelitian ini SMP SSN Kabupaten Pati yang difokuskan pada perencanaan dan pelaksanaan pengelolaan kelas pembelajaran sains.Data penelitian diperoleh melalui: observasi, wawancara, angket, dan dokumentasi. Data yang diperoleh bersifat subjektif, berupa hasil observasi, wawancara, dan angket.Hasil penelitian menunjukkan: perencanaan pengelolaan kelas di SMP SSN dalam pembelajaran sains berkategori baik

PENGARUH MODEL PEMBELAJARAN AUDITORY, INTELLECTUALLY, AND REPETITION TERHADAP KEMAMPUAN PEMAHAMAN KONSEP DI SMP PUSTEK SERPONG

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Selviani Fitri

2016-09-01

Full Text Available This research aims to know the effect of learning model of Auditory, Intellectually, and Repetition (AIR about cube concept comprehension to students' VIII grade at SMP Pustek Serpong. Kind of the research is experiment quasi research. The research instrument that used is analysis question pretest and postest. The data analyze by using normality test, homogenity test, and t-test. The result of the research show that there is the different ability of cube concept comprehension among students' who gave air learning model with convensional learning model. Keywords: Model Pembelajaran Auditory Intellectually and Repetition (AIR, concept comprehension

KEEFEKTIFAN MODEL PEMBELAJARAN KOOPERATIF TIPE SQ3R TERHADAP KEMAMPUAN PEMECAHAN MASALAH SISWA SMP KELAS VII

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Dian Teguh Firmansyah

2012-10-01

Full Text Available This study aims to determine the effectiveness of cooperative learning model types Survey Question Read Recite Review (SQ3R to mathematical problem solving abilities of students in the junior high school grade VII of material relationships between angles. The population in this study is students of grade VII SMP N 1 Pagerbarang school year 2011/2012. The samples taken by cluster random sampling technique so namely studentsinclassVIIB as control group and studentsinclass VIIC as experiment group. Design used in this research is true experimental design posttest only control type. Results showed that the averagetest scores mathematical problem solving abilities of students in class taught by cooperative learning model types SQ3Rof material relationships between angles achieve minimal completeness criteria(KKM applies in SMP N 1 Pagerbarang, with many students who achieve KKM is more than equal 75%, and average test scores mathematical problem solving abilities of students in classtaught by cooperative learning model typesSQ3Rof material relationships between anglesmore than the average test scoresmathematical problem solving abilities of students in class taught by expository model. Based on the research results can be concluded that the cooperative learning model types SQ3R is effective to improve students problem solving skills students grade VII to the material relationships between angles.

PERANAN SIARAN TELEVISI EDUKASI DALAM MENDUKUNG TERCIPTANYA SUMBER DAN MOTIVASI BELAJAR BAGI SISWA SMP DI YOGYAKARTA

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Muhammad Ragil Kurniawan

2014-04-01

Full Text Available Penelitian ini bertujuan untuk mengungkap peranan siaran televisi edukasi (TVe sebagai sumber belajar dan motivasi belajar bagi siswa SMP di Kodya Yogyakarta. Penelitian menggunakan metode gabungan (mixed method yaitu penelitian kuantitatif jenis survei diikuti dengan penelitian kualitatif. Pengumpulan data kuantitatif dilakukan dengan menggunakan angket. Sedangkan pengumpulan data kualitatif menggunakan metode wawancara mendalam dan observasi. Data kuantitatif dianalisis menggunakan analisis deskriptif, sedangkan data kualitatif dianalisis menggunakan model Miles dan Huberman. Populasi penelitian adalah 17 SMP di Kodya Yogyakarta. Hasil penelitian menunjukkan: (1 Siaran TV Edukasi belum memberikan peran yang signifikan dalam meningkatkan sumber belajar bagi siswa SMP di Kodya Yogyakarta. (2 Siaran TV Edukasi belum berperan yang signifikan dalam meningkatkan motivasi belajar bagi siswa SMP di Kodya Yogyakarta. Kata kunci: televisi edukasi (TVe, sumber belajar, motivasi belajar.

76 FR 41260 - Supplemental Funding for the Senior Medicare Patrol (SMP) Program

Science.gov (United States)

2011-07-13

... additional funding to double the size of the SMP program. The SMP program expansion has resulted in... DEPARTMENT OF HEALTH AND HUMAN SERVICES Administration on Aging Supplemental Funding for the Senior Medicare Patrol (SMP) Program ACTION: Notice of intent to provide supplemental funding to the...

RANCANG BANGUN SISTEM INFORMASI PEMBAYARAN SUMBANGAN PENUNJANG PENDIDIKAN DI SMP MUHAMMADIYAH I JERUKLEGI-CILACAP

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Melia Dianingrum

2012-02-01

Full Text Available Tujuan penelitian ini adalah membuat sistem informasi pembayaran SPP di SMP Muhammadiyah I Jeruklegi. Metode pengumpulan data yang digunakan untuk membuat aplikasi ini adalah metode kepustakaan, metode observasi, dan metode wawancara. Untuk pengembangan sistem dalam penelitian ini menggunakan metode SDLC (System Development Life Cycle, dengan teknik pengembangan sistem waterfall model dan analisis PIECES untuk menganalisis kelayakan tersebut. Hasil penelitian ini berupa aplikasi sistem pembayaran SPP di SMP Muhammadiyah I Jeruklegi-Cilacap.

PEMBELAJARAN KETERAMPILAN MEMBACA INTENSIF PARAGRAF DENGAN MODEL PENGEMBANGAN KONSEP MELALUI AKTIVITAS BAHASA (PKMAB DAN MODEL PENDAHULUAN, PENGANALISISAN, PENGULANGAN (P3 PADA SISWA SMP DILIHAT DARI KARAKTERSOSIAL DAN MANDIRI

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Nurriyah -

2014-08-01

Full Text Available Permasalahan penelitian adalah seberapa besar peningkatan keterampilan membaca intensif paragraf peserta didik yang berkarakter Sosialdan Mandiriyang diperlakukan dengan model pembelajaran PKMABdanP3di SMP. Tujuan penelitian ini untuk menentukan besaran hasil peningkatan keterampilan membaca intensif paragraf pada peserta didik yang berkarakter Sosialdan Mandiriyang diperlakukan dengan model pembelajaran PKMABdanP3di SMP.Penelitian menggunakan metode eksperimen dengan populasi keterampilan membaca intensif paragrafpeserta didik SMP di wilayah Tegal dan Brebes.Sampel penelitianadalah keterampilan membaca intensif paragrafpeserta didik Kelas VII SMP Warureja dan Brebes. Pengumpulan data kuantitatif dilaksanakan melalui tes keterampilan membaca intensif paragraf, dianalisismenggunakanbefore-after dant-Tes Dua Sampel Independen. Pengumpulan data kualitatif menggunakan panduan observasi, dokumentasi, dan angketskala sikap untuk mengungkap karakter peserta didik.Hasil penelitian membuktikan bahwa model PKMAB lebih efektif meningkatkan kemampuan membaca intensif paragraf pada peserta didik, terutama yang berkarakter Sosial. Sedangkan model P3 lebih efektif meningkatkan kemampuan membaca intensif paragraf pada peserta didik, terutama yang berkarakter Mandiri. The problem in this research is the comparison of intensive paragraph reading skill in the socializer children and in the children whose characters are director who are treated using PKMAB and P3 in Junior High School.The method used in this study was an experiment with quantitative and qualitative analysis techniques.The study sample is the intensive paragraph penganalisisaning skill on the students of grade VII of SMPN 1 Warureja and SMPN 5 Brebes. Quantitative data collection was carried out through intensive paragraph penganalisisaning test and analyzed by using before-after and t-Test for Two Independent Samples to know the level of intensive paragraph penganalisisaning skill on the learner

PENGEMBANGAN MODEL PERMAINAN “VOLTACER” BOLA VOLI KELAS VII SMP NEGERI 1 GODONG KECAMATAN GODONG KABUPATEN GROBOGAN TAHUN 2014

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Ahmad Sugeng Riyadi

2015-12-01

Full Text Available The purpose of this study was to determine the Game Model Development "Voltacer" extra-curricular volleyball in grade 1 SMP Negeri 1 Godong District of Godong Grobogan. This study uses pengembanganyang research refers to the model development (research-based devolepment of Sugiyono. The results of the study of small-scale test results obtained from the evaluation of the percentage is 84.28% penjas experts (meet both criteria, whereas the percentage of expert learning I was 90.00% (meets both criteria, expert pembeajaran II was 88.87% (meet both criteria. The results of the questionnaire the percentage of students in a small-scale test was 91.48% (meets criteria very well. Meanwhile, from the student questionnaire in a large-scale test results obtained percentage of 95.70% (meets criteria very well.Based on the research results, it can be concluded that the model of the game "voltacer" volley ball can be used for class VII student extracurricular khususya SMP Negeri 1 Godong. Suggestions submitted penjasorkes that teachers should use the model of the game "voltacer" volleyball volleyball in the delivery of material by adjusting the infrastructure and facilities available in the school.

PERBEDAAN SELF-REGULATED LEARNING DITINJAU DARI POLA ASUH ORANGTUA PADA SISWA KELAS VIII SMP FRANSISKUS DAN SMP PGRI 01 SEMARANG

OpenAIRE

Lintang Januardini; Sri Hartati; Tri Puji Astuti

2015-01-01

Relationship between parents and adolescents influence achievement at school. The research was conducted to determine differences of self-regulated learning (SRL) in terms of parenting style. The population is 8th grade students of junior high school in SMP Fransiskus and SMP PGRI 01 Semarang. The hypothesis is there are differences of SRL in terms of parenting style. Parenting is overall characteristic of parent’s behavior on adolescents, including a response in the form of parental warmth, ...

Penerapan Model Pembelajaran Treffinger dengan Bantuan Media Audio Visual Untuk Meningkatkan Aktivitas dan Hasil Belajar IPA Terpadu pada Siswa Kelas VII SMP Frater Makassar

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Nur Indah Sari

2016-08-01

Full Text Available Penelitian ini adalah  jenis Penelitian Tindakan Kelas (Classroom Action Research yang bertujuan untuk meningkatkan hasil belajar siswa pada pembelajaran IPA Terpadu melalui penerapan model pembelajaran Treffinger dengan bantuan media audio visual pada materi ekosistem siswa kelas VII SMP FRATER Makassar. Teknik pengumpulan data dilakukan dengan observasi aktivitas belajar siswa dan evaluasi pada setiap akhir siklus. Data yang terkumpul dianalisis dengan menggunakan analisis statistik deskriptif dan dilengkapi dengan tabel frekuensi dan presentase. Dari hasil kegiatan pembelajaran yang telah dilakukan terjadi peningkatan hasil belajar siswa, siklus I sebanyak 14 orang dengan presentase 37,83%, sedangkan pada siklus II sebanyak 32 orang dengan persentase 86,48%. dan terjadi peningkatan aktivitas belajar siswa, Semangat siswa dalam mengikuti pembelajaran IPA Terpadu pada siklus I 50,15% dan  meningkat pada siklus II menjadi 80,05%. Hasil penelitian ini menunjukkan bahwa penerapan model pembelajaran Treffinger dengan bantuan media audio visual dapat meningkatkan hasil belajar IPA Terpadu pada materi ekosistem pada siswa kelas VII A SMP FRATER Makassar.Kata kunci: model pembelajaran treffinger, hasil belajar, ipa terpadu.ABSTRACTThis study is classroom action research study that aims to increase activity and study results of Integrated Science of  student by using Treffinger model with audio visual media on ecosystem material of Class VII Student at SMP Frater Makassar. Data collection used in this study was observation and achievement test in the end of every cycle. Analytical data by using descriptive statistical analysis include the frequency tables and percentages. The results of this study indicate that: Treffinger  model with audio visual media showed a positive tendency from 14 students with 37,83% in cycle I and improve to 32 students with 86,48% in cycle II and showed a positive tendency on student’s activity in study. Student�

PENGEMBANGAN PAKET PELATIHAN KEMANDIRIAN BELAJAR DENGAN STRATEGI INDIVIDUAL LEARNING PLAN UNTUK SISWA SMP

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Tri Cahyono

2016-12-01

Pengelolaan belajar yang dilakukan secara mandiri, memungkinkan siswa untuk belajar sesuai minat dan tanpa paksaan dari pihak lain sehingga akan berdampak positif terhadap prestasi belajar yang diraihnya. Penelitian ini bertujuan untuk mengembangkan paket pelatihan kemandirian belajar dengan menggunakan strategi individual learning plan untuk siswa SMP. Pengembangan paket pelatihan ini menggunakan model penelitian pengembangan Borg & Gall (1983. Berdasarkan hasil penilaian ahli dan pengguna, paket pelatihan kemandirian belajar dengan menggunakan strategi individual learning plan untuk siswa SMP telah memenuhi kriteria kelayakan dan keberterimaan. Uji efektivitas kepada berbagai subjek yang berbeda perlu dilakukan pada penelitian selanjutnya sehingga kekurangan paket pelatihan yang dikembangkan dalam pelatihan ini bisa disempurnakan.

PENINGKATAN AKTIVITAS DAN HASIL BELAJAR MENGGUNAKAN METODE EKSPERIMEN PADA SISWA KELAS VII SMP NEGERI 1 PURBOLINGGO TAHUN PELAJARAN 2013/2014

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Endang Kurniawati

2014-03-01

Full Text Available The purposeofthis studyis: to describethe use ofexperimental method sin enhancingthe activity oflearning physicsclass VII students of SMPN1Purbolinggoandto describethe use ofexperimentalmethodsin improvingstudentlearning outcomesphysicsclass VII SMP N 1 Purbolinggo.This study uses a Class Action Research and 4-cycle stages: planning, action, observation and reflection for further action. The study lasted 2 cycles each cycle consisting of 2 meetings. As the subjects in this study were VII.F grade students of SMP N 1 Purbolinggo of 40 people. Means of collecting data in the form of sheets of observations and tests. From the analysis and the results of this study concluded that the use of experimental methods in the learning process can improve the activity and student learning outcomes VII.F SMP N 1 Purbolinggo on the material and temperature measurements with an average of 11.56% increase in activity. Average learning outcomes increased by 55%. Thus it can be advisable for teachers to improve the activity and student learning outcomes using experimental methods.

Standardization of SMP procedure and its impact on outcome

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Rachita S Dhurat

2017-01-01

Full Text Available Background: Cosmetic deformities can result from various types of alopecia or even post hair transplantation procedures. Patients with such deformities seek aesthetically appealing longer-lasting options. Scalp concealers are commonly used by men and women to camouflage these deformities. Scalp micropigmentation (SMP is one of the concealers recently gaining popularity. Objectives: SMP is a novel technique wherein microdot tattoos are placed in a stippling pattern to mimic hair follicles that are cut close to the scalp and various variables affecting its outcome were evaluated. Methods: Forty-five subjects were recruited for the study. The various factors affecting outcome of SMP—angle of needle against the scalp, depth of needle into the scalp, time of the needle contact in scalp, speed of the rotor, resistance of scalp, color of pigment, viscosity of dye, needle number, needle thickness, and pattern of dot placement—were systematically studied in 15 patients through clinical photographs and trichoscopy. Ideal depth of pigment deposition was assessed through histopathological examination. After using these optimum variables, standardized SMP was performed in 30 patients with hair loss (3 patients with cicatricial and 27 patients with diffuse non-cicatricial alopecia. SMP was also used to create an aesthetically denser hairline. The outcome of the procedure was evaluated using standardized global photographs. Results: The ideal parameters were established to achieve standard reproducible results. There were great patient satisfaction and acceptance of the procedure. All the patients showed moderate to great improvement after the procedure with satisfactory scalp coverage. Adverse events were transient which were seen in the form of edema and redness. Conclusion: SMP offers a non-medical, tattoo-based cosmetically appealing and effective “cover-up” that hides the unsightly conditions. The cosmetic tattoo placement creates an illusion of

The SmpB C-terminal tail helps tmRNA to recognize and enter stalled ribosomes

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Mickey R. Miller

2014-09-01

Full Text Available In bacteria, transfer-messenger RNA (tmRNA and SmpB comprise the most common and effective system for rescuing stalled ribosomes. Ribosomes stall on mRNA transcripts lacking stop codons and are rescued as the defective mRNA is swapped for the tmRNA template in a process known as trans-translation. The tmRNA–SmpB complex is recruited to the ribosome independent of a codon–anticodon interaction. Given that the ribosome uses robust discriminatory mechanisms to select against non-cognate tRNAs during canonical decoding, it has been hard to explain how this can happen. Recent structural and biochemical studies show that SmpB licenses tmRNA entry through its interactions with the decoding center and mRNA channel. In particular, the C-terminal tail of SmpB promotes both EFTu activation and accommodation of tmRNA, the former through interactions with 16S rRNA nucleotide G530 and the latter through interactions with the mRNA channel downstream of the A site. Here we present a detailed model of the earliest steps in trans-translation, and in light of these mechanistic considerations, revisit the question of how tmRNA preferentially reacts with stalled, non-translating ribosomes.

RTEMS SMP and MTAPI for Efficient Multi-Core Space Applications on LEON3/LEON4 Processors

Science.gov (United States)

Cederman, Daniel; Hellstrom, Daniel; Sherrill, Joel; Bloom, Gedare; Patte, Mathieu; Zulianello, Marco

2015-09-01

This paper presents the final result of an European Space Agency (ESA) activity aimed at improving the software support for LEON processors used in SMP configurations. One of the benefits of using a multicore system in a SMP configuration is that in many instances it is possible to better utilize the available processing resources by load balancing between cores. This however comes with the cost of having to synchronize operations between cores, leading to increased complexity. While in an AMP system one can use multiple instances of operating systems that are only uni-processor capable, a SMP system requires the operating system to be written to support multicore systems. In this activity we have improved and extended the SMP support of the RTEMS real-time operating system and ensured that it fully supports the multicore capable LEON processors. The targeted hardware in the activity has been the GR712RC, a dual-core core LEON3FT processor, and the functional prototype of ESA's Next Generation Multiprocessor (NGMP), a quad core LEON4 processor. The final version of the NGMP is now available as a product under the name GR740. An implementation of the Multicore Task Management API (MTAPI) has been developed as part of this activity to aid in the parallelization of applications for RTEMS SMP. It allows for simplified development of parallel applications using the task-based programming model. An existing space application, the Gaia Video Processing Unit, has been ported to RTEMS SMP using the MTAPI implementation to demonstrate the feasibility and usefulness of multicore processors for space payload software. The activity is funded by ESA under contract 4000108560/13/NL/JK. Gedare Bloom is supported in part by NSF CNS-0934725.

Analysis of the primary structure and post-translational modifications of the Schistosoma mansoni antigen Smp28 by electrospray mass spectrometry

NARCIS (Netherlands)

Bouchon, B.; Jaquinod, M.; Klarskov, K.; Trottein, F.; Klein, Michele; Van Dorsselaer, A.; Bischoff, Rainer; Roitsch, C.

1994-01-01

The Schistosoma mansoni glutathione-S-transferase with an apparent molecular mass of 28 kDa, Smp28, has a blocked N-terminus which has been elucidated with the aid of the cDNA sequence combined with mass spectrometry and amino acid composition analysis of the N-terminal tryptic peptide. The blocked

Meningkatkan Hasil Belajar Matematika Melalui Model Pembelajaran Kooperatif Tipe Jigsaw pada Siswa SMP

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Nasruddin Nasruddin

2017-08-01

Full Text Available In this study, we discuss about Jigsaw type cooperative learning model to improve mathematics learning outcomes on the basic competence of cubes and beams of students of class VIIIA SMP. This research is a Classroom Action Research (CAR conducted in SMPN 2 Lasusua Year Learning 2016/2017 even semester. This study uses two cycles, each cycle has procedures such as planning, action, observation and reflection. The results of this study indicate the implementation of cooperative learning model jigsaw type can improve student learning outcomes in mathematics subjects. The value after the first cycle action increased compared with the initial test of 45,85 to 65,75. Furthermore the average score of students after the second cycle action increased compared with the average score of students on the implementation of the first cycle action that is 65,75 to 80,60 and has met the predetermined performance indicators that 85% of students have received a minimum score of 65.

PENINGKATAN AKTIVITAS DAN HASIL BELAJAR SISWA SMP MELALUI MODEL PEMBELAJARAN KOOPERATIF TIPE STUDENT TEAMS ACHIEVEMENT DIVISION DENGAN METODE EKSPERIMEN

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Muhammad Dian Hadi Kesuma

2013-12-01

Full Text Available The objectives in these studies are (1 determine the activity of theeighth grade students of SMP 2 Labuan Deli in learning activities using an experimental method of inquiry. (2 Determine the increased student’s activityin class VIII of SMP Negeri 2 Labuan Deli in solving physics problems after applied the experimental method. This study is a classroom action research. Research subject is class VIII SMP 2 Semester 2 Labuan Deli T.P 2012/2013numbered 31 students consisting of 13 men and 18 women. Object of thisresearch is to apply the learning peruses STAD cooperative learning modelthrough experimental methods. This result show (1 There is an increase instudent learning outcomes Junior High School eighth grade 2 Labuan Deli isshown from: (a the results of tests of student learning in the first cycle,namely: mean = 58.92 with the percentage of completeness = 19.36%; (btests of student learning outcomes in the second cycle is the average 75.70,percentage of completeness = 58.92%. Completeness percentage increased by61.24% and 0.41 normalized gain index or criteria being. (2 There is anincrease in the activity of the eighth grade students of SMP Negeri 2 LabuanDeli is shown from the first cycle only average 65.60 and 81.65 in the secondcycle. The results of this study can be used as input for teachers in an effort toincrease the activity and student learning outcomes by applying experimentalmethods.

EVALUASI PROGRAM AKSELERASI DI SMP NEGERI KOTA AMBON

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David Tuhurima

2016-06-01

Full Text Available This research is aimed to evaluate acceleration program in SMP Negeri 6 Ambon which is include four components such as: (1Context (2Input (3 Process, and (4Product. This is an evaluative research using descriptive analysis. This research informants are principals, viceprincipals, program coordinators, teachers, school committees, parents, and students accelerated program. Research sites in SMP Negeri 6 Ambon. The data is collected using interview, observation and documentation study techniques. For the data validation, this research used triangulation of sources and techniques. The results shows that, from context, the implementation of the acceleration program is a school’s initiative as an effort to address the needs and provide the education services for special smart learners (IQ  130 as well as the effectiveness of school facilities and infrastructure utilization. From the point of input including: (a the program policy, the school has permission from the department as the juridical basis for accelerated program implementation, and (b planning program: recruitment of learners are in accordance with the criteria, curriculum acceleration program already differentiated, educators (teachers already meets the qualifications and criteria as teacher in class acceleration, infrastructure and financing program is sufficient to support the accelerated program. In terms of Process, acceleration program in SMP Negeri 6 Ambon has been implemented in accordance with the planning program, although there are still some shortcomings and obstacles. Recruitment of learners already implemented, curriculum adjustments will only be visible on the implementation of the teaching and learning activities, educators (teachers are still there who do not meet the qualifications and criteria as a teacher in class acceleration, infrastructure is not sufficient to support an accelerated program of activities, and financing programs that is still lacking. The

Analysis of Parallel Algorithms on SMP Node and Cluster of Workstations Using Parallel Programming Models with New Tile-based Method for Large Biological Datasets.

Science.gov (United States)

Shrimankar, D D; Sathe, S R

2016-01-01

Sequence alignment is an important tool for describing the relationships between DNA sequences. Many sequence alignment algorithms exist, differing in efficiency, in their models of the sequences, and in the relationship between sequences. The focus of this study is to obtain an optimal alignment between two sequences of biological data, particularly DNA sequences. The algorithm is discussed with particular emphasis on time, speedup, and efficiency optimizations. Parallel programming presents a number of critical challenges to application developers. Today's supercomputer often consists of clusters of SMP nodes. Programming paradigms such as OpenMP and MPI are used to write parallel codes for such architectures. However, the OpenMP programs cannot be scaled for more than a single SMP node. However, programs written in MPI can have more than single SMP nodes. But such a programming paradigm has an overhead of internode communication. In this work, we explore the tradeoffs between using OpenMP and MPI. We demonstrate that the communication overhead incurs significantly even in OpenMP loop execution and increases with the number of cores participating. We also demonstrate a communication model to approximate the overhead from communication in OpenMP loops. Our results are astonishing and interesting to a large variety of input data files. We have developed our own load balancing and cache optimization technique for message passing model. Our experimental results show that our own developed techniques give optimum performance of our parallel algorithm for various sizes of input parameter, such as sequence size and tile size, on a wide variety of multicore architectures.

Analysis of Parallel Algorithms on SMP Node and Cluster of Workstations Using Parallel Programming Models with New Tile-based Method for Large Biological Datasets

Science.gov (United States)

Shrimankar, D. D.; Sathe, S. R.

2016-01-01

Sequence alignment is an important tool for describing the relationships between DNA sequences. Many sequence alignment algorithms exist, differing in efficiency, in their models of the sequences, and in the relationship between sequences. The focus of this study is to obtain an optimal alignment between two sequences of biological data, particularly DNA sequences. The algorithm is discussed with particular emphasis on time, speedup, and efficiency optimizations. Parallel programming presents a number of critical challenges to application developers. Today’s supercomputer often consists of clusters of SMP nodes. Programming paradigms such as OpenMP and MPI are used to write parallel codes for such architectures. However, the OpenMP programs cannot be scaled for more than a single SMP node. However, programs written in MPI can have more than single SMP nodes. But such a programming paradigm has an overhead of internode communication. In this work, we explore the tradeoffs between using OpenMP and MPI. We demonstrate that the communication overhead incurs significantly even in OpenMP loop execution and increases with the number of cores participating. We also demonstrate a communication model to approximate the overhead from communication in OpenMP loops. Our results are astonishing and interesting to a large variety of input data files. We have developed our own load balancing and cache optimization technique for message passing model. Our experimental results show that our own developed techniques give optimum performance of our parallel algorithm for various sizes of input parameter, such as sequence size and tile size, on a wide variety of multicore architectures. PMID:27932868

PENERAPAN TEKNOLOGI WEB SEKOLAH BAGI SMP DAN SMA MUHAMMADIYAH KARTASURA

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Heru Supriyono

2016-03-01

Full Text Available Observation and interview with headmasters, teachers and administrative employees results showed that one of main problems faced by SMP Muhammadiyah 1 Kartasura and SMA Muhammadiyah 4 Kartasura is the do not have a representative school website. Based on this observation, after making discussion with headmasters, the community services team proposed an implementation of school website and train one of chosen teacher to manage implemented website. The outcomes of the community service activities are involving a school website for SMP Muhammadiyah 1 Kartasura and SMA Muhammadiyah 4 Kartasura and scientific publication draft. The contribution of each school is including providing information which will be uploaded to the website, providing fee for domain and hosting cost, and providing facilities for administrator training. The duration of this commuity services is three months. The results of the community services is both SMP Muhammadiyah 1 Kartasura dan SMA Muhammadiyah 4 Kartasura are now have representative website for their promotion and administative activities.

PENGEMBANGAN MODEL EVALUASI PROSES PEMBELAJARAN MATEMATIKA DI SMP BERDASARKAN KURIKULUM 2013

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Sugiyanto Sugiyanto

2015-06-01

Abstract This studi aims to develop a model for an evaluation of mathematics learning processes at junior high schools (JHSs based on Curriculum 2013 and evaluate the effectiveness of the model develo-ped. This was a research and development study. The subject of the research was the teachers, principals, and supervisors. The data collecting instruments were questionnaires and observational sheet. The development process was carried out in 4 stages namely: (1 preliminary investigation; (2 planning development, validation; (3 tryout; (4 product finalization. The try out was perform-ed in 3 stages with the increasing number of participants for each stage. The learning process evaluation model was supported by instrument to assess lesson plans, learning implementation, and the implementation of learning outcome assessment. The content validity was assessed through focus group discussion (FGD. The construct validity was assessed by the factor analysis, and the reliabilities were estimated by the Intraclass Correlation Coefficient (ICC. The result of the research was a model of evaluation of mathematics learning processes at junior high schools (JHSs based on Curriculum 2013, consisting of procedures, evaluation guideline and the well de-signed instruments. Based on the try out, all of the instruments have had good suitability, because construct validity and reliability meet all of the academic requirements. According to the evalua-tion from the practitioners and the model users, the model of the evaluation of mathematics learn-ing processes at junior high schools (JHSs based on Curriculum 2013 was very effective to be implemented. Keywords: development model, evaluation of learning processes, SMP mathematics

PENINGKATAN KUALITAS PEMBELAJARAN PPKN MELALUI PENERAPAN PROBLEM BASED LEARNING DI SMP

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Y. Yuniwati

2016-12-01

Full Text Available Penelitian ini bertujuan untuk meningkatkan kualitas pembelajaran PPKn melalui penerapan model  Problem based learning di kelas VIII A semester 1 SMP Negeri 2 Manisrenggo Kabupaten Klaten tahun akademik 2014/2015. Penelitian ini merupakan penelitian tindakan kelas (classroom action research dengan desain Kemmis & Taggart yang dilaksanakan dalam III siklus. Jenis tindakan yang dilaksanakan adalah penerapan model Problem based learning dalam pembelajaran PPKn.  Langkah-langkah pembelajaran meliputi mengidentifikasi masalah, menggali sumber informasi yang relevan, belajar secara mandiri, menyelidiki dan menginterpretasi data yang terkumpul, memilih beberapa alternatif solusi masalah, dengan mempertimbangkan pendapat atau informasi dari kolabolator. Pengumpulan data dilakukan melalui observasi, tes tertulis, wawancara, dan catatan lapangan. Analisis data dilakukan secara kualitatif dengan teknik yang dikembangkan Miles dan Huberman. Hasil penelitian menunjukan bahwa penerapan model Problem based learning dapat meningkatkan kualitas pembelajaran PPKn pada aspek proses pembelajaran dan hasil belajar yang komprehensif (kognitif, afektif, dan psikomotorik.   THE IMPROVEMENT OF THE CIVIV EDUCATION LEARNING QUALITY THROUGH THE APPLICATION OF THE PROBLEM BASED–LEARNING  AT SMP Abstract This study aimed to improve the Civic Education learning quality through the application of the problem- based learning model at Grade VIII A of SMP Negeri 2 Manisrenggo in semester 1 of the 2014/2015 academic year. This was a classroom action research (CAR study employing the design by Kemmis & MacTaggart, carried out in three cycles. The action implemented was the application of the problembased learning model in the Civic Education learning. The learning steps included identifying problems, looking for relevant information sources, learning autonomously, investigating and interpreting the collected data, and selecting several alternative problem solutions by taking

Peningkatan Hasil Belajar Fisika Melalui Model Pembelajaran Kooperatif Tipe Team Assisted Individualization pada Siswa Kelas VII.D SMP Negeri 2 Bangkala Kabupaten Jeneponto

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Suhardi Suhardi

2015-12-01

Full Text Available Abstract This research is a class action (Classroom Action Research, which aims to improve learning outcomes Physics VII.D grade students of SMP Negeri 2 Bangkala through Cooperative Learning Model Team Assisted Individualization. The subjects were VII.D grade students of SMP Negeri 2 Bangkala on odd semester 2013/2014 academic year consisting of 36 students. Research conducted two cycles consisting of four activities, namely: planning, action, observation and reflection. In the first cycle was conducted over four sessions and the second cycle was conducted over four sessions. Data collection was done by studying the results of the final tests of learning at the end of the first cycle and the end of the second cycle. The collected data were analyzed quantitatively and qualitatively. The results of the quantitative analysis of physics learning outcome data indicate that the number of students classified as learning completed the first cycle were completed only 22 0rang 61.11% and in the second cycle up to 25 people who completed 69.44%. The results of the qualitative analysis showed an increase in activity of students during the learning process through a model of Cooperative Learning Physics Team Assisted Individualization type. Based on these results it can be concluded that the physics learning through cooperative learning model of Type Team Assisted Individualization can improve student learning outcomes. Keywords: Results Learning, Cooperative Learning Model Team Assisted Individualization, Qualitative, and Student Activities Abstrak Penelitian ini adalah penelitian tindakan kelas (Classroom Action Research yang bertujuan meningkatkan hasil belajar Fisika siswa kelas VII.D SMP Negeri 2 Bangkala melalui Model Pembelajaran Kooperatif Tipe Team Assisted Individualization. Subjek penelitian ini adalah siswa kelas VII.D SMP Negeri 2 Bangkala pada semester ganjil tahun pelajaran 2013/2014 yang terdiri dari 36 siswa. Penelitian dilaksanakan dua

SMP Bladder Tooling for Manufacturing Composites, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — CRG's shape memory polymer (SMP) Bladder Tooling is a cutting-edge manufacturing technology that can meet the manufacturing needs of the Ares launch vehicles. This...

Snowpack spatial and temporal variability assessment using SMP high-resolution penetrometer

Science.gov (United States)

Komarov, Anton; Seliverstov, Yuriy; Sokratov, Sergey; Grebennikov, Pavel

2017-04-01

This research is focused on study of spatial and temporal variability of structure and characteristics of snowpack, quick identification of layers based on hardness and dispersion values received from snow micro penetrometer (SMP). We also discuss the detection of weak layers and definition of their parameters in non-alpine terrain. As long as it is the first SMP tool available in Russia, our intent is to test it in different climate and weather conditions. During two separate snowpack studies in plain and mountain landscapes, we derived density and grain size profiles by comparing snow density and grain size from snowpits and SMP measurements. The first case study was MSU meteorological observatory test site in Moscow. SMP data was obtained by 6 consecutive measurements along 10 m transects with a horizontal resolution of approximately 50 cm. The detailed description of snowpack structure, density, grain size, air and snow temperature was also performed. By comparing this information, the detailed scheme of snowpack evolution was created. The second case study was in Khibiny mountains. One 10-meter-long transect was made. SMP, density, grain size and snow temperature data was obtained with horizontal resolution of approximately 50 cm. The high-definition profile of snowpack density variation was acquired using received data. The analysis of data reveals high spatial and temporal variability in snow density and layer structure in both horizontal and vertical dimensions. It indicates that the spatial variability is exhibiting similar spatial patterns as surface topology. This suggests a strong influence from such factors as wind and liquid water pressure on the temporal and spatial evolution of snow structure. It was also defined, that spatial variation of snowpack characteristics is substantial even within homogeneous plain landscape, while in high-latitude mountain regions it grows significantly.

Translational research into species differences of endocrine toxicity via steroidogenesis inhibition by SMP-028 — For human safety in clinical study

International Nuclear Information System (INIS)

Nishizato, Yohei; Imai, Satoki; Okahashi, Noriko; Yabunaka, Atsushi; Kunimatsu, Takeshi; Kikuchi, Kaoru; Yabuki, Masashi

2014-01-01

SMP-028 is a drug candidate developed for the treatment of asthma. In a 13-week repeated dose toxicity study of SMP-028 in rats and monkeys, differences of endocrine toxicological events between rats and monkeys were observed. In rats, these toxicological events mainly consisted of pathological changes in the adrenal, testis, ovary, and the other endocrine-related organs. On the other hand, in monkeys, no toxicological events were observed. The goal of this study is to try to understand the reason why only rats, but not monkeys, showed toxicological events following treatment with SMP-028 and to eventually predict the possible toxicological effect of this compound on human endocrine organs. Our results show that SMP-028 inhibits neutral cholesterol esterase more strongly than other steroidogenic enzymes in rats. Although SMP-028 also inhibits monkeys and human neutral cholesterol esterase, this inhibition is much weaker than that of rat neutral cholesterol esterase. These results indicate (1) that the difference in endocrine toxicological events between rats and monkeys is mainly due to inhibition of steroidogenesis by SMP-028 in rats, not in monkeys, and (2) that SMP-028 may not affect steroidogenesis in humans and therefore might cause no endocrine toxicological events in clinical studies. - Highlights: • SMP-028 inhibits neutral CEase more strongly than other steroidogenic enzymes in rats. • Inhibition of neutral CEase in rats by SMP-028 suppresses steroidogenesis in vivo. • SMP-028 does not inhibit neutral CEase in monkeys in vivo. • Steroidogenesis pathway in monkeys treated with SMP-028 was not suppressed. • SMP-028 may not inhibit LIPE in humans in vivo

Translational research into species differences of endocrine toxicity via steroidogenesis inhibition by SMP-028 — For human safety in clinical study

Energy Technology Data Exchange (ETDEWEB)

Nishizato, Yohei, E-mail: yohei-nishizato@ds-pharma.co.jp [Preclinical Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 33-94, Enoki-cho, Suita, Osaka 564-0053 (Japan); Imai, Satoki [Preclinical Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 33-94, Enoki-cho, Suita, Osaka 564-0053 (Japan); Okahashi, Noriko [Research Planning and Intelligence, Dainippon Sumitomo Pharma Co., Ltd., 33-94, Enoki-cho, Suita, Osaka 564-0053 (Japan); Yabunaka, Atsushi; Kunimatsu, Takeshi [Preclinical Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 33-94, Enoki-cho, Suita, Osaka 564-0053 (Japan); Kikuchi, Kaoru [Innovative Drug Discovery Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 33-94, Enoki-cho, Suita, Osaka 564-0053 (Japan); Yabuki, Masashi [Preclinical Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 33-94, Enoki-cho, Suita, Osaka 564-0053 (Japan)

2014-05-01

SMP-028 is a drug candidate developed for the treatment of asthma. In a 13-week repeated dose toxicity study of SMP-028 in rats and monkeys, differences of endocrine toxicological events between rats and monkeys were observed. In rats, these toxicological events mainly consisted of pathological changes in the adrenal, testis, ovary, and the other endocrine-related organs. On the other hand, in monkeys, no toxicological events were observed. The goal of this study is to try to understand the reason why only rats, but not monkeys, showed toxicological events following treatment with SMP-028 and to eventually predict the possible toxicological effect of this compound on human endocrine organs. Our results show that SMP-028 inhibits neutral cholesterol esterase more strongly than other steroidogenic enzymes in rats. Although SMP-028 also inhibits monkeys and human neutral cholesterol esterase, this inhibition is much weaker than that of rat neutral cholesterol esterase. These results indicate (1) that the difference in endocrine toxicological events between rats and monkeys is mainly due to inhibition of steroidogenesis by SMP-028 in rats, not in monkeys, and (2) that SMP-028 may not affect steroidogenesis in humans and therefore might cause no endocrine toxicological events in clinical studies. - Highlights: • SMP-028 inhibits neutral CEase more strongly than other steroidogenic enzymes in rats. • Inhibition of neutral CEase in rats by SMP-028 suppresses steroidogenesis in vivo. • SMP-028 does not inhibit neutral CEase in monkeys in vivo. • Steroidogenesis pathway in monkeys treated with SMP-028 was not suppressed. • SMP-028 may not inhibit LIPE in humans in vivo.

Pengaruh Model Inkuiri Terbimbing (Guided Inquiry) Disertai Metode Mencongak Terhadap Hasil Belajar Siswa Pada Pembelajaran IPA (Fisika) Kelas VII Di SMP Al-Maliki Sukodono - Lumajang

OpenAIRE

Nurkhasanah, Ika; Prihandono, Trapsilo; Supriadi, Bambang

2016-01-01

The study is focused in implementation of guided inquiry model with mencongak methods. Purpose of this study is to assess the influence of guided inquiry model with mencongak methods against student's result learning, and student's activity in learning physics which applied guided inquiry model with methods mencongak. The type of this study is research experiment conducted in SMP Al-Maliki Sukodono-Lumajang. Data collection method used is a documentary, observation, interview, and test. Data ...

PODAAC-SMP40-3TMCS

Data.gov (United States)

National Aeronautics and Space Administration — This is the PI-produced JPL SMAP-SSS V4.0 CAP, level 3, monthly mapped sea surface salinity product from the NASA Soil Moisture Active Passive (SMAP) observatory. It...

PODAAC-SMP40-3TPCS

Data.gov (United States)

National Aeronautics and Space Administration — This is the PI-produced JPL SMAP-SSS V4.0 CAP, 8-day running mean, level 3 mapped, sea surface salinity product from the NASA Soil Moisture Active Passive (SMAP)...

PENGARUH MOTIVASI DAN KEPUASAN KERJA TERHADAP KINERJA GURU DI SMP NEGRI 5 MAGELANG

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Lutviani Rahayu

2014-11-01

Full Text Available Tujuan penelitian ini adalah untuk mengetahui pengaruh motivasi dan kepuasan kerja terhadap kinerja guru di SMP Negeri 5 Magelang baik secara simultan maupun parsial. Populasi dalam penelitian ini adalah guru PNS di SMP Negeri 5 Magelang sebanyak 38 responden. Metode pengumpulan data yang digunakan adalah metode kuesioner dan dokumentasi. Teknik analisis data menggunakan analisis deskriptif. Hasil analisis menunjukkan bahwa persamaan garis regresi linier berganda yaitu Y = 0,182 + 0,283 + e; Y (kinerja guru, X1 (motivasi, X2 (kepuasan kerja. Hasil tersebut menunjukkan bahwa ada pengaruh antara motivasi dan kepuasan kerja terhadap kinerja guru di SMP Negeri 5 Magelang. OutputSPSS pengaruh X1 terhadap Y sebesar 0,643 dengan nilai hubungan parsial sebesar 12,1% pada taraf signifikansi 0,035, sedangkan X2 terhadap Y sebesar 0,178 dengan hubungan parsial sebesar 17,8% pada taraf signifikansi 0,011. Jadi semakin baik motivasi dan kepuasan kerja maka semakin baik pula kinerja guru. The purpose of this research is to find out whether there is an influence of motivation and job satisfaction on theteachers’ performance in SMP Negeri 5 Magelang either simultaneously or partially. The population in this research was a public civil servants in SMP Negeri 5 Magelang are 38 respondents. The collecting method was questionnaire and documentation. The analysis data technique were descriptive. The analysis showed that the multiple linear regression equation is Y = 0,182X1 + 0,283X2 + E, with Y (teachers’ performance, X1 (motivation, X2 (job satisfaction. These results indicated that there was an influence of motivation and job satisfaction on the teachers’s performance in SMP Negeri 5 Magelang. The SPSS output effect of X1 on Y of 0.643 with a value 12.1% partial relationship at a significance level of 0.035, while the X2 to Y of 0.178 with 17.8% partial relations at a significance level of 0.011. So the better motivation and job satisfaction, the better the

PENYELENGGARAAN PROGRAN SD-SMP SATU ATAP DALAM LATAR BUDAYA RUMAH BETANG KALIMANTAN TENGAH

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Rudi Hasan

2014-06-01

Abstrak: Penyelenggaraan Progran SD-SMP Satu Atap dalam Latar Budaya Rumah Betang Kali­mantan Tengah. Penelitian ini bertujuan untuk mendeskripsikan penyelengaaraan program SD-SMP Satu Atap dalam latar budaya rumah Betang Kalimantan Tengah yang dikaitkan dengan struktur birokrasi, sumber daya, dan komunikasi. Penelitian kualitatif dilaksanakan di tiga lokasi, yaitu pada SMPN Satu Atap 1 Mihing Raya, SMPN Satu Atap 2 Kurun, dan SMPN Satu Atap 3 Tewah di Kabupaten Gunung Mas, Propinsi Kalimantan Tengah. Hasil penelitian menunjukkan bahwa acuan standar yang jelas, koordinasi yang intensif, dan pemberdayaan sumber daya manusia yang tepat sesuai dengan pendekatan nilai-nilai budaya rumah Betang dapat mencapai penyelenggaraan program SD-SMP Satu Atap yang efektif. Hal itu juga didukung oleh pengelolaan sumberdaya dan komunikasi yang mendasarkan diri pada nilai kekeluargaan, kebersamaan, loyalitas, dan keakraban.

Estimativa da acidez potencial pelo método do pH SMP em solos com elevado teor de matéria orgânica Estimation of potencial acidity by the pH SMP method in soils with higher organic matter content in Brazil

Directory of Open Access Journals (Sweden)

Marcos Gervasio Pereira

2006-01-01

Full Text Available Apesar do potencial para uso agrícola e das características edáficas peculiares, poucos são os métodos desenvolvidos para a recomendação de adubação e calagem para os solos com elevado teor de matéria orgânica. O objetivo deste estudo foi definir um modelo matemático que estime a acidez potencial (H+Al a partir do pH SMP medido em água e em solução de CaCl2 0,01 mol L-1 em solos com elevado teor de matéria orgânica. Foram utilizadas 41 amostras de horizontes superficiais de solos com elevado teor de matéria orgânica de vários Estados do Brasil. Os resultados demonstraram que a acidez potencial pode ser estimada por meio da regressão da solução-tampão SMP (r =0,85**. Também foi observada correlação significativa (r = 0,65** entre o pH em CaCl2 0,01 mol L-1 e o pH SMP.In spite of agricultural potential for use and the peculiar edaphic characteristics, there are few methods developed for manuring and liming recommendation for soils with high organic matter contents. The objective of this study was to determine a mathematical model that estimates the potencial acidity with pH SMP measured in water and in solution of CaCl2 0.01 mol L-1 in soil with high organic matter content. Forty one surface soil samples of Histosols and other soils whith higher organic matter content of different states of Brazil were utilized. The results showed that potential acidity can be estimated by pH SMP buffer suspension regression ( R=0.85** and that in pH determined in CaCl2 0.01 mol L-1 was significantly correlated (R= 0.65** to pH determined in SMP.

Molecular water motions of skim milk powder solutions during acidification studied by 17O and 1H nuclear magnetic resonance and rheology

DEFF Research Database (Denmark)

Møller, S M; Whittaker, A. K.; Stokes, J. R.

2011-01-01

The molecular motion of water was studied in glucono-δ-lactone-acidified skim milk powder (SMP) solutions with various pH values and dry matter contents. NMR relaxometry measurements revealed that lowering the pH in SMP solutions affected 17O and 1HT2 relaxation rates almost identically. Conseque......The molecular motion of water was studied in glucono-δ-lactone-acidified skim milk powder (SMP) solutions with various pH values and dry matter contents. NMR relaxometry measurements revealed that lowering the pH in SMP solutions affected 17O and 1HT2 relaxation rates almost identically...... could contribute to the initial decrease in 17O and 1Hrelaxation rate in the pH range between 6.6 and 5.5 for 15% SMP and in the pH range between 6.6 and 5.9 for 25% SMP. However, below pH 5.5 the viscosity and 17Oand 1HNMRrelaxation rates did not correlate, revealing that the aggregation of casein...... micelles, which increases viscosity below pH 5.5, does not involve major repartitioning of water....

Pengembangan LKS Untuk Melatih Kemampuan Berpikir Kritis dalam Mata Pelajaran Matematika di Kelas VII SMP

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Puji Astuti

2017-10-01

Full Text Available Tujuan pembelajaran matematika adalah untuk melatih siswa berpikir kritis. Oleh karena itu, perlu dikembangkan Lembar Kerja Siswa (LKS untuk melatih kemampuan berpikir kritis siswa. Penelitian ini bertujuan untuk menghasilkan LKS yang berkarakteristik untuk melatih kemampuan berpikir kritis siswa kelas VII SMP. Sampel pada penelitian ini adalah kelas VII7 berjumlah 30 siswa semester II SMP Negeri 9 Palembang. Metode penelitian yang digunakan adalah metode penelitian pengembangan yang terdiri dari analisis, desain, evaluasi dan revisi. Pengumpulan data dilakukan dengan cara prototyping.  Prototyping dilakukan untuk mengetahui bagaimana karakteristik LKS untuk melatih kemampuan berpikir kritis siswa kelas VII SMP. Hasil penelitian ini adalah karakteristik LKS untuk melatih kemampuan berpikir kritis siswa kelas VII SMP. Kata kunci: Kemampuan berpikir kritis, Lembar Kerja Siswa    Mathematics learning aims to develop students critical thinking. Therefore, it is necessary to develop Student Worksheet to train students' critical thinking skills. This research aims to develop student worksheet that has characteristics of critical thinking skill for 7th grade Junior High School students (SMP. The sample in this research is VII7 class with 30 students of the second semester of SMP Negeri 9 Palembang. The research method used is a development research method that consists of analysis, design, evaluation and revision. Data collection is done by prototyping. Prototyping was used to find out how the characteristics of student worksheet to develop critical thinking ability of grade  7th students. The result of this research is characteristic of student worksheet to develop critical thinking ability of 7th grade Junior High School student. Keywords: critical thinking ability, student worksheet

PENGEMBANGAN MODEL PEMBELAJARAN LOMPAT JAUH GAYA JONGKOK MELALUI PERMAINAN LEVEL JUMP DAN GARIS TANGKAP PADA SISWA KELAS VII SMP NEGERI 1 TULIS KECAMATAN TULIS KABUPATEN BATANG TAHUN 2013

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Rinanto

2015-06-01

Full Text Available The purpose of this study is to produce a product development model of learning style long jump squat in Physical Education Sport and Health through the game levels to jump and catch the lines of class VII students of SMP N 1 TULIS .This research is a development . The analysis procedure includes product development product that will be created , developed the initial product , expert validation and revision , testing and revision of small groups , large groups and test the final product . The data was collected using a questionnaire derived from expert evaluation , as well as using field observations obtained from the students . The data analysis technique used is descriptive percentages . From the existing research results it can be concluded that the model of learning and jump levels game fishing line can be used as a teaching model for students of class VII Penjasorkes SMP N 1 TULIS , because in reality the learning model contributes three aspects of cognitive , affective and psychomotor and more create a pleasant atmosphere so that students become motivated.

Pengaruh Cyberbullying Di Media Sosial Terhadap Perilaku Reaktif Sebagai Pelaku Maupun Sebagai Korban Cyberbullying Pada Siswa Kristen SMP Nasional Makassar

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Mira Marleni Pandie

2016-03-01

Full Text Available Penelitian ini bertujuan untuk mengetahui pengaruh cyberbullying  terhadap perilaku reaktif sebagai pelaku sekaligus sebagai korban cyberbullying pada siswa. Penelitian yang digunakan adalah penelitian kuantitatif dengan menggunakan metode survei dengan mengambil sampel sebanyak 40 orang dari SMP Nasional Kota Makassar. Siswa yang dimaksud dalam penelitian ini adalah siswa SMP kelas VII sampai kelas IX karena tanggap terhadap teknologi dan  pada masa ini terjadi perubahan secara fisik dan psikis yang membawa siswa pada suatu fase yang disebut masa transisi, labil, mencari identitas dan mencari public figure. Hasil dari penelitian ini adalah terbuktinya hipotesis bahwa ada pengaruh antara perilaku pelaku cyberbullying dengan perilaku reaktif siswa Kristen korban cyberbullying dengan signifikansi 0,037<0,05. Dengan demikian jelas bahwa bila makin tinggi perilaku reaktif pelaku maka makin tinggi pula perilaku reaktif korban. Semakin rendah perilaku reaktif pelaku maka makin rendah pula perilaku reaktif korban cyberbullying.  

PENGEMBANGAN MEDIA PEMBELAJARAN IPS SEJARAH MELALUI APLIKASI SWAY BERKONTEN INDIS DI SMP NEGERI 8 MADIUN

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Khoirul Huda

2017-08-01

Full Text Available Education in Indonesia is seen from the perspective of the present field experiencing many multicomplex problems. The role of educators in utilizing learning conditions through the composition of teaching tools has not been powerless. Minimnya in designing models, strategies or media that are not adequate. This condition is often seen in SMP Negeri 8 Madiun. Based on the observations mention First, the teaching model of IPS History is still conventional with the lecture method. Educators have not taken advantage of interesting and interactive media variations leading to saturation. Second, the limitations of resource utilization. Whereas the surrounding environment learning source can be used for learning IPS History such as Indis building (Housing Employee KA, SMPN 1 Madiun School Building, City Hall, Giringan PLTA, pagotan sugar factory and kawedanan Uteran or Kandangan coffee garden. The purpose of this research is to develop the media office Sway berkonten Indis to form a draft prototype that has been tested. Research type is Research and Development. The result of this research is limited test at SMP Negeri 10 Madiun got average score 4,23, produce very good score (X => 4,21 so media is considered feasible. The expanded scale test at SMP Negeri 8 Madiun shows the average of 60,35 (pre-test and 94,46 (post-test, and statistic test of Paired Samples T Test. The result of significance value is 0.00, so the result shows less than 0.05 and  means rejected so that there has been a significant increase.

UPAYA MENINGKATKAN PEROLEHAN KOSAKATA DALAM PEMAHAMAN MEMBACA BAHASA INGGRIS MENGGUNAKAN VSS PADA SISWA SMP

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Windarti Windarti

2016-06-01

Full Text Available Penelitian ini bertujuan untuk meningkatkan perolehan kosakata dalam pemahaman membaca bahasa Inggris menggunakan Vocabulary Self-Collection Strategy (VSS siswa kelas VII SMP Negeri 3 Kalasan. Metode penelitian yang digunakan yaitu penelitian tindakan kelas (PTK, yang terdiri dari dua siklus. Tiap siklus terdiri dari empat tahap, yaitu perencanaan, pelaksanaan, pengamatan, dan refleksi. Subjek penelitian ini adalah 32 siswa kelas VII B SMP Negeri 3 Kalasan tahun ajaran 2013/2014. Teknik pengumpulan data yang digunakan yaitu observasi, tes, dan wawancara. Analisis data yang digunakan yaitu deskriptif kuantitatif dan deskriptif kualitatif. Hasil penelitian ini menunjukan bahwa penerapan strategi VSS dapat digunakan untuk meningkatkan perolehan kosakata dalam pemahaman membaca bahasa Inggris. Peningkatan hasil belajar siswa ditunjukkan dengan meningkatnya jumlah siswa yang lulus standar KKM pada siklus I dan II. Nilai rata-rata tes pada siklus I adalah 77,2. Nilai rata-rata tes pada siklus II adalah 82,4. Kesimpulan pada penelitian ini adalah bahwa penerapan strategi VSS dapat meningkatkan perolehan kosakata bahasa Inggris dalam pemahaman membaca siswa kelas VII SMP Negeri 3 Kalasan. Kata kunci: VSS, perolehan kosakata, pemahaman membaca bahasa Inggris. THE EFFORT TO IMPROVE VOCABULARY ACQUISITION IN ENGLISH READING COMPREHENSION USING VSS ON THE STUDENTS OF SMP Abstract This study aims to improve vocabulary acquisition in English reading comprehension using Vocabulary Self-Collection Strategy (VSS on the seventh grade students of SMP Negeri 3 Kalasan. This was an action reserch study consisting of two cycles. Each cycle consisted of four steps, namely planning, implementation, observation, and reflection. The research subjects were 32 seventh grade students of SMP 3 Kalasan in the academic year of 2013/2014. The data were collected through observation, tests, and interviews and analyzed by means of quantitative and qualitative descriptive

Eksperimentasi Model Pembelajaran Kooperatif Tipe Teams Games Tournament (Tgt) dan Fan-n-pick pada Prestasi Belajar Matematika Ditinjau dari Kecemasan pada Matematika Siswa SMP Negeri di Kabupaten Magelang

OpenAIRE

Setyowati, Anna; Budiyono, Budiyono; Riyadi, Riyadi

2013-01-01

The aim of the research was to determine the effect of learning models on mathematics achievement viewed from the student's mathematics anxiety. The learning model compared were Teams Games Tournament of cooperative learning model, Fan-N-Pick of coopeartive learning model, and direct instruction model The method which was applied in this research was quasi-experimental with 3×3 factorial design done in class VIII second semester of Junior High School (SMP) In Magelang Regency Academic Year 20...

SMC SMP 24: A newly radio-detected planetary nebula in the small Magellanic cloud

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Bojičić I.S.

2010-01-01

Full Text Available In this paper we report a new radio-continuum detection of an extragalactic planetary nebula (PN: SMC SMP 24. We show the radio-continuum image of this PN and present the measured radio data. The newly reduced radio observations are consistent with the multi-wavelength data and derived parameters found in the literature. SMC SMP 24 appears to be a young and compact PN, optically thick at frequencies below 2 GHz.

SMC SMP 24: A Newly Radio-Detected Planetary Nebula in the Small Magellanic Cloud

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Bojicic, I. S.

2010-12-01

Full Text Available In this paper we report a new radio-continuum detection of an extragalactic planetary nebula (PN: SMC~SMP~24. We show the radio-continuum image of this PN and present the measured radio data. The newly reduced radio observations are consistent with the multi-wavelength data and derived parameters found in the literature. SMC~SMP~24 appears to be a young and compact PN, optically thick at frequencies below 2~GHz.

ANALISIS TERHADAP TINGGINYA ANGKA PUTUS SEKOLAH SISWA SMP TERBUKA

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T Effendy Suryana

2017-06-01

Based on the result above, the related ones  had better  find a fund for scholarship, in order to make a teaching learning activities at SMP Negeri 1 Pacet as main school, and to empower  all facilities in teaching learning process.

KOMPUTERISASI PENGOLAHAN DATA PERPUSTAKAAN SMP 1 KALIWIRO BERBASIS MULTI USER

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Andi Dwi Riyanto

2008-08-01

Full Text Available Komputerisasi Pengolahan Data Perpustakaan SMP 1 Kaliwiro di angkat menjadi tema pada penelitian ini karena berdasar penelitian oleh penulis, sistem pengolahan data yang ada pada SMP tersebut masih bersifat manual, sehingga penulis berkeinginan mengganti sistem yang ada dengan sistem komputer. Ruang lingkup dari tugas akhir ini dibatasi pada peng-input-an data anggota, buku dan invent buku, kemudian transaksi peminjaman, pengembalian dan perpanjangan buku, serta output berupa laporan. Program pengolahan data perpustakaan ini mendukung konsep MULTIUSER, yaitu dapat diakses oleh beberapa komputer secara bersamaan. Namun dari program aplikasi yang dibuat, masih banyak kemungkinan pengembangan yang dapat dilakukan di kemudian hari. Misalnya seperti untuk tampilan interface bisa dibuat cantik sesuai selera atau permintaan instansi, kemudian bisa dikembangkan menjadi berbasis WEB agar dapat diakses melalui internet, atau bahkan WAP agar dapat diakses melalui handphone.

Comparação de métodos para estimar a acidez potencial mediante determinação do pH SMP em Organossolos da Serra do Espinhaço Meridional Comparison of estimation methods of potential acidity by determination of the pH SMP in Organosol of the region Serra do Espinhaço Meridional, Brazil

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Enilson de Barros Silva

2008-10-01

Full Text Available Apesar do potencial para uso agrícola e das características edáficas peculiares, poucos trabalhos são desenvolvidos para estimar a acidez potencial dos solos com elevado teor de matéria orgânica. O objetivo deste trabalho foi definir um modelo matemático que estime a acidez potencial (H + Al a partir do pH SMP após determinação do pH do solo em água ou em solução de CaCl2 10 mmol L-1, com leitura do pH na suspensão ou sobrenadante da solução SMP de equilíbrio, em determinada relação solo:tampão SMP, em Organossolos da Serra do Espinhaço Meridional (SdEM, Estado de Minas Gerais, situada entre 17 ° 30 ' a 20 ° 30 ' S e 43 ° a 44 ° W. Foram utilizadas 22 amostras de Organossolos classificados como Organossolo Háplico sáprico térrico, Organossolo Háplico fíbrico típico e Organossolo Háplico hêmico típico da SdEM. A acidez potencial dos Organossolos da SdEM pode ser estimada satisfatoriamente por meio do pH SMP na relação solo:tampão SMP de 10:10 medido na suspensão solo-solução SMP associada à rotina de determinação do pH do solo em água. O C orgânico foi o atributo químico que mais influenciou a acidez potencial dos Organossolos da SdEM.In spite of the agricultural use potential and the peculiar edaphic characteristics, few studies have been conducted to estimate the potential acidity of soils with high organic matter content. The objective of this study was to establish a mathematical model that could estimate the potential acidity (H + Al based on the pH SMP after determination of the soil pH in water and in CaCl2 10 mmol L-1 solution with reading of the pH in the suspension or supernatant of the equilibrium solution SMP in a certain soil: SMP buffer ratio for Organosols from the of Serra do Espinhaço Meridional (SdEM region (between 17 ° 30 ' and 20 ° 30 ' S, and 43 ° and 44 ° W in Minas Gerais State, Brazil. Twenty-two Organosol samples from the SdEM were used. The soils are classified as

A D'-type symbiotic binary in the planetary nebula SMP LMC 88

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Iłkiewicz, Krystian; Mikołajewska, Joanna; Miszalski, Brent; Kozłowski, Szymon; Udalski, Andrzej

2018-05-01

SMP LMC 88 is one of the planetary nebulae (PNe) in the Large Magellanic Cloud. We identify in its spectrum Raman scattered O VI lines at 6825 and 7083 Å. This unambiguously classifies the central object of the nebula as a symbiotic star (SySt). We identified the cold component to be a K-type giant, making this the first D'-type (yellow) SySt discovered outside the Galaxy. The photometric variability in SMP LMC 88 resembles the orbital variability of Galactic D'-type SySt with its low amplitude and sinusoidal light-curve shape. The SySt classification is also supported by the He I diagnostic diagram.

KONTRIBUSI DISIPLIN KERJA, MOTIVASI KERJA, DAN PERSEPSI GURU TENTANG GAYA KEPEMIMPINAN KEPALA SEKOLAH TERHADAP UNJUK KERJA GURU SMP NEGERI SSN DI KABUPATEN SEMARANG

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Nuk Isdiyati

2015-07-01

towards teacher performance at SMP N with National Standard School (SSN Semarang, this is indicated with the acquisition probability value <0.05 with the effective contribution counted 17.25% and the classical assumption test results showed that the regression model is not biased or problems of classical assumptions (normality, linearity, and multicollinearity that could otherwise BLUE (Best, Linear, Unbiased, Estimator.

PENGARUH PENGGUNAAN SMARTPHONE TEHADAP POLA KOMUNIKASI INTERPESONAL SISWA SMP NEGERI 50 BANDUNG

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Pitthauly Haomasan

2018-03-01

Full Text Available ABSTRACTNowadays smartphones can be consumed from young to old age. Motives teenagers in using thesmartphone quite diverse, namely, the sophistication of features, fast internet access, ease of accessto social media, entertainment facilities and help in doing homework. In early January 2017, SMPNegeri 50 Bandung set a ban on bringing smartphones to school, due to the recent years the influenceof smartphone making problems in school. This study was conducted to find out how much the influenceof using smartphones to interpersonal communication patterns of students of SMP Negeri 50 Bandung.This research is associated with Uses and Gratification theory and the method is quantitative with thetype of descriptive research. This study involved one independent variable and one dependent variable.Using probability sampling method with Slovin approach with the number of respondents 82 people.Data analysis techniques used are descriptive and multiple linear regression analysis. Based on theresults of simultaneous hypothesis testing, a significant influence on the use of smartphones againstinterpesonal communication patterns. This is evidenced by the value of F-count(41.644> F-table(2.722 with a significance level of 5%. The result of coefficient of determination showed that Frequencyof Use, the Variety of Content and Activity give influence of 61,6% to Interpersonal CommunicationPattern of students of SMP Negeri 50 Bandung. While the action of 38.4% is the contribution of othervariables that are not examined in this study. Can be concluded that SMP Negeri 50 Bandung prohibitsbringing smartphones to school so obtained despite the prohibition of bringing the smartphone in effectto make high interpersonal communication patterns of students of SMP Negeri 50 Bandung.Keywords: smartphone usage, interpersonal communication, pattern of interpersonal communication,uses and gratification.

Pengaruh Model Pembelajaran Think Pair Share Terhadap Kemampuan Menemukan Gagasan Utama Teks Deskripsi Oleh Siswa Kelas VII SMP Negeri 3 Kisaran Tahun Pembelajaran 2016/2017

OpenAIRE

Siregar, Khairani; A, Abdurrahman

2017-01-01

Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan model pembelajaranThink Pair Share terhadap kemampuan menenukan gagasan Utama teks deskripsi oleh siswa kelas VII SMP Negeri 3 Kisaran tahun pembelajaran 2016/2017. Populasi penelitian ini berjumlah 266 siswa. Dari 266 siswa, ditetapkan 32 siswa yang diambil secara acak. Metode yang digunakan dalam penelitian ini adalah metode eksperimen one-group pre-test post-test design.Instrumen yang digunakan untuk menjaring data adalah tes u...

The flagellar protein FLAG1/SMP1 is a candidate for Leishmania-sand fly interaction.

Science.gov (United States)

Di-Blasi, Tatiana; Lobo, Amanda R; Nascimento, Luanda M; Córdova-Rojas, Jose L; Pestana, Karen; Marín-Villa, Marcel; Tempone, Antonio J; Telleria, Erich L; Ramalho-Ortigão, Marcelo; McMahon-Pratt, Diane; Traub-Csekö, Yara M

2015-03-01

Leishmaniasis is a serious problem that affects mostly poor countries. Various species of Leishmania are the agents of the disease, which take different clinical manifestations. The parasite is transmitted by sandflies, predominantly from the Phlebotomus genus in the Old World and Lutzomyia in the New World. During development in the gut, Leishmania must survive various challenges, which include avoiding being expelled with blood remnants after digestion. It is believed that attachment to the gut epithelium is a necessary step for vector infection, and molecules from parasites and sand flies have been implicated in this attachment. In previous work, monoclonal antibodies were produced against Leishmania. Among these an antibody was obtained against Leishmania braziliensis flagella, which blocked the attachment of Leishmania panamensis flagella to Phlebotomus papatasi guts. The protein recognized by this antibody was identified and named FLAG1, and the complete FLAG1 gene sequence was obtained. This protein was later independently identified as a small, myristoylated protein and called SMP1, so from now on it will be denominated FLAG1/SMP1. The FLAG1/SMP1 gene is expressed in all developmental stages of the parasite, but has higher expression in promastigotes. The anti-FLAG1/SMP1 antibody recognized the flagellum of all Leishmania species tested and generated the expected band by western blots. This antibody was used in attachment and infection blocking experiments. Using the New World vector Lutzomyia longipalpis and Leishmania infantum chagasi, no inhibition of attachment ex vivo or infection in vivo was seen. On the other hand, when the Old World vectors P. papatasi and Leishmania major were used, a significant decrease of both attachment and infection were seen in the presence of the antibody. We propose that FLAG1/SMP1 is involved in the attachment/infection of Leishmania in the strict vector P. papatasi and not the permissive vector L. longipalpis.

Hubungan Kecemasan Sosial dan Kematangan Emosi dengan Kematangan Seksual Remaja SMP di Kabupaten Bantul Yogyakarta

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Endang Sri Lestari

2012-06-01

Full Text Available This research aims to find out some factors related to the sexual maturity, such as the social anxiety and emotional maturity on the adolescents of the SMP in Kabupaten Bantul, Yogyakarta. The hypotheses which are presented in this research are: First; there is a relation between the social anxiety and emotional maturity towards the sexual maturity; Second, there is a negative relation between the social anxiety and sexual maturity; Third, there is a positive relation between the emotional maturity and sexual maturity.The research participants were 70 male and female adolescents in SMP N 2 Banguntapan, Kabupaten Bantul. The data gathering was carried out in two phases, First, by applying the sampling area technique in order to determine the research location and Second, by applying the cluster random sampling technique to determine the research sample subject. Meanwhile, the research instrument which was employed was the scale of social anxiety, emotional maturity and sexual adolescents maturity. The double-regression technique was applied to analyze the data in this research.The result of this research showed that: First, there was a relation between social anxiety and emotional maturity towards the sexual maturity in adolescentsof the SMP in Kabupaten Bantul, Yogyakarta (R=0,667, R2=0,445, F-regression= 26,911 and the significant level for about p< 0,01. Second, there was a negative relation between the social anxiety and sexual maturity in adolescentof the SMP in Kabupaten Bantul, Yogyakarta (R partial=0,632, p=0,01. Third, there was a positive relation between the emotional maturity and sexual maturity in adolescebtsof the SMP in Kabupaten Bantul, Yogyakarta (R partial=0,358, level p<0,01.Key words:  Sexual Maturity, Social Anxiety, Emotional Maturity.

Super-mini percutaneous nephrolithotomy (SMP): a new concept in technique and instrumentation.

Science.gov (United States)

Zeng, Guohua; Wan, ShawPong; Zhao, Zhijian; Zhu, Jianguo; Tuerxun, Aierken; Song, Chao; Zhong, Liang; Liu, Ming; Xu, Kewei; Li, Hulin; Jiang, Zhiqiang; Khadgi, Sanjay; Pal, Shashi K; Liu, Jianjun; Zhang, Guoxi; Liu, Yongda; Wu, Wenqi; Chen, Wenzhong; Sarica, Kemal

2016-04-01

To present a novel miniature endoscopic system designed to improve the safety and efficacy of percutaneous nephrolithotomy, named the 'super-mini percutaneous nephrolithotomy' (SMP). The endoscopic system consists of a 7-F nephroscope with enhanced irrigation and a modified 10-14 F access sheath with a suction-evacuation function. This system was tested in patients with renal stones of operative duration was 45.6 min. The initial stone-free rate (SFR) was 90.1%. The SFR at the 3-month follow-up was 95.8%. Three patients required auxiliary procedures for residual stones. Complications occurred in 12.8% of the patients, all of which were Clavien grade ≤II and no transfusions were needed. In all, 72.3% of the patients did not require any kind of catheter, while 19.8% had JJ stents and 5.7% had nephrostomy tubes placed. The mean hospital stay was 2.1 days. SMP is a safe and effective treatment for renal stones of <2.5 cm. SMP may be particularly suitable for patients with lower pole stones and stones that ae not amenable to retrograde intrarenal surgery. © 2015 The Authors BJU International © 2015 BJU International Published by John Wiley & Sons Ltd.

Green function of the model two-centre quantum-mechanical problem

International Nuclear Information System (INIS)

Khoma, M.V.; Lazur, V.Yu.

2002-01-01

The expansions of a Green function for the Simmons molecular potential (SMP) in terms of spheroidal function are built. The solutions of degenerate hypergeometric equation are used as basis function system while expanding regular and irregular model spheroidal functions into series. Rather simple three-terms recurrence relations are obtained for the coefficients of these expansions. Much attentions is given to different asymptotic representation as well as Sturmian expansions of the Green function of the two-centre SMP wave functions. In all cases considered the Green function is reduced to the form similar to the Hostler's representation of the Coulomb Green function

SURVEI SARANA DAN PRASARANA PENJASORKES DI SMP NEGERI SE- KECAMATAN PURWAREJA KLAMPOK KABUPATEN BANJARNEGARA TAHUN AJARAN 2012/ 2013

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Lukman Baharuddin

2015-04-01

Full Text Available This research intent to know condition of medium and prasarana is sport and health physical education at SMP Country one Purwareja Klampok's district Banjarnegara's Regency school year 2012 / 2013. Method that is utilized in this research is quantitative. Approaching that is utilized gets analisis's descriptive character. This observational type is observational survey. This observational population is all SMP Country One Purwareja Klampok's district that total 3 schools . Sample took by samplings totaled tech and result sample as much 3 SMP. Methodic data collecting that digunkan is methodic questionnaire or kuesioner, observation method, method documents, and interview's method. Base observational result to be known that medium average and prasarana for branch sporting athletic with presentase 65.04%, basketball (44.00%, football (54.76%, for volleyball (53.57%, badminton (73.91%, gymnastics (50.00%, school health (55.34%.Of research and study result gets to be concluded that medium and prasarana penjasorkes at SMP Country One Purwareja Klampok's district Banjarnegara's regency adequately is equal to Penjasorkes's learning.

Innovative Soil Management Practices (SMP) Assessment in Europe and China

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Barão, Lúcia

2017-04-01

The growing world population poses a major challenge to global agricultural food and feed production through the pressure to increase agricultural outputs either by increasing the land area dedicated to agriculture or by productivity increases. Whether in developed or developing regions, agricultural intensification based on conventional approaches has resulted in severe environmental impacts and innovative soil management practices are needed to halter ongoing soil degradation and promote sustainable land management capable to produce more from less. The iSQAPER project - Interactive Soil Quality Assessment in Europe and China for Agricultural Productivity and Environmental Resilience - aims to develop a Soil Quality app (SQAPP) linking soil and agricultural management practices to soil quality indicators. This easy friendly tool will provide a direct and convenient way to advise farmers and other suitable actors in this area, regarding the best management practices to be adopted in very specific and local conditions. In this particular study from iSQAPER, we aimed to identify the most promising innovative soil management practices (SMP) currently used and its geographical distribution along different pedo-climatic regions in Europe (Boreal, Atlantic, Mediterranean Temperate, Mediterranean Semi-Arid, Southern Sub-Continental and Northern Sub-Continental) and China (Middle Temperate, Warm temperate and Central Asia Tropical). So far we have identified 155 farms where innovative SMP's are used, distributed along 4 study site regions located in China (Qiyang, Suining, Zhifanggou and Gongzhuling) and 10 study site regions located in Europe (The Netherlands, France, Portugal, Spain, Greece, Slovenia, Hungary, Romania, Poland and Estonia) and covering the major pedo-climatic regions. From this identification we concluded that the most used innovative SMP's in the study site regions in Europe are Manuring & Composting (14%), Min-till (14%), Crop rotation (12

EFFORTS TO IMPROVE LEARNING MOTIVATION OF STUDENT WITH CONTENT MASTERY IN SMP NEGERI 1 METRO

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Hadi Pranoto

2013-09-01

Full Text Available Abstract: The study design using action research applied in guidance and counseling services (follow-services research. Subjects in this study, researchers took VII.4 grade students of SMP Negeri 1 Metro Odd Semester Lesson Tabun 2012/2013. Of the 24 students, there are 10 students who experience a lack of motivation to learn to 41.66%. The method used in collecting data by observation and field notes. Analysis of the data used is the analysis of qualitative and quantitative data. Validity test is done through assessment experts /specialists ie counseling teachers SMP Negeri 1 Metro, other friends peer discussions that instrument with other friends FKIP students with courses in counseling. The results of this study, it can be concluded that the results obtained through the implementation of the procurement of content services in increasing the motivation of learners class VII.4 SMP Negeri 1 Metro Tabun Odd Semester Lesson 20 12/20 13 is visible from the change in behavior and ability of learners in learners become more willing to meet the needs of achievement, students can understand or have confidence in learning, learners have the ability to overcome failure in learning, and learners have a good competitiveness in the service learning. Through mastery of content supplied by BK teacher can increase the motivation of learners class VII.4 SMP Negeri 1 Metro Odd Semester Academic Year 201212013. There is increased the motivation of learners in the first cycle seen from the average percentage that is equal to 27.5% and in the second cycle of 75 %, resulting in an increase of 47.5%. Response and activity VIl.4 grade students of SMP Negeri 1 Metro Odd Semester Lesson Tabun 2012/2013 on the service in the content mastery enhance learning motivation is very positive, it is shown by the participation of learners in the service following the mastery of content, learner motivation and enthusiasm in participating services as well as content mastery

Keefektifan Auditory Intellectually Repetition Berbantuan LKPD terhadap Kemampuan Penalaran Peserta Didik SMP

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Ika Martyana Handayani

2014-06-01

Full Text Available AbstrakPenelitian ini bertujuan untuk mengetahui keefektifan pembelajaran model pembelajaran Audi-tory intellectually Repetition (AIR berbantuan LKPD terhadap kemampuan penalaran matematis peserta didik. Populasi dalam penelitian ini adalah peserta didik kelas VIII SMP Negeri 1 Blado tahun pelajaran 2012/2013. Metode penelitian ini merupakan penelitian eksperimen yang dila-kukan pada dua kelas yang memiliki kemampuan setara dengan model pembelajaran yang berbe-da. Berdasarkan pemilihan secara acak terpilih dua kelompok yaitu kelompok eksperimen yang diterapkan pembelajaran matematika menggunakan model pembelajaran AIR dan kelompok kontrol yang diterapkan model pembelajaran STAD. Hasil penelitian menunjukkan bahwa hasil belajar peserta didik pada aspek kemampuan penalaran matematis yang diajar menggunakan mo-del pembelajaran AIR mencapai ketuntasan klasikal, persentase hasil belajar peserta didik pada aspek kemampuan penalaran matematis pada kelompok eksperimen lebih baik dari kelompok kontrol, rata-rata hasil belajar peserta didik pada aspek kemampuan penalaran matematis pada kelas eksperimen lebih baik dari kelas kontrol. Berdasarkan pembahasan di atas dapat disimpul-kan bahwa pembelajaran menggunakan model AIR berbantuan LKPD efektif terhadap kemam-puan penalaran matematis peserta didik. Kata kunci:          Auditory Intellectually Repetition; Keefektifan; Kemampuan Penalaran.  AbstractThe purpose of this study was to determine learning using the Auditory Intellectually Repetition model approaches effective to student’s reasoning ability. The population in this study was students of grade VIII SMP N 1 Blado academic year 2012/2013. This research method is an experimental research that applied on two classes who have similar abilities with different learning models. Based on the random selection of two groups chosen experimental applied mathematics learning using learning model AIR and the control group were applied learning model

PERBEDAAN SELF-REGULATED LEARNING DITINJAU DARI POLA ASUH ORANGTUA PADA SISWA KELAS VIII SMP FRANSISKUS DAN SMP PGRI 01 SEMARANG

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Lintang Januardini

2015-07-01

Full Text Available Relationship between parents and adolescents influence achievement at school. The research was conducted to determine differences of self-regulated learning (SRL in terms of parenting style. The population is 8th grade students of junior high school in SMP Fransiskus and SMP PGRI 01 Semarang. The hypothesis is there are differences of SRL in terms of parenting style. Parenting is overall characteristic of parent’s behavior on adolescents, including a response in the form of parental warmth, sensitivity and criticism, discipline, and involvement (control. Self-regulated learning is the ability of students to use metacognition, motivation and behavior to achieve learning goals. Method of data collection used two scales namely Parenting Scale and Self Regulated Learning scale. Parenting Scale consists of 42 aitem (α = 0.931 and the SRL scale consists of 37 aitem (α = 0.906. This study involved 208 students. Sampling technique carried out by cluster random sampling. Data analysis was performed by one way analysis of variance (one way-Anova. Based on the data analysis, obtained F count = 3152 with p = 0.029 (p<0.05. This result indicates that there are significant differences in SRL on students with the type of parenting authoritative, authoritarian, permissive, and neglect, so the hypothesis was accepted. Keywords: Parenting style, SRL, 8th grade students

Reduction of SR Ca2+ leak and arrhythmogenic cellular correlates by SMP-114, a novel CaMKII inhibitor with oral bioavailability.

Science.gov (United States)

Neef, Stefan; Mann, Christian; Zwenger, Anne; Dybkova, Nataliya; Maier, Lars S

2017-07-01

Sarcoplasmic reticulum (SR) Ca 2+ leak induced by Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) is centrally involved in atrial and ventricular arrhythmogenesis as well as heart failure remodeling. Consequently, treating SR Ca 2+ leak has been proposed as a novel therapeutic paradigm, but compounds for use in humans are lacking. SMP-114 ("Rimacalib") is a novel, orally available CaMKII inhibitor developed for human use that has already entered clinical phase II trials to treat rheumatoid arthritis. We speculated that SMP-114 might also be useful to treat cardiac SR Ca 2+ leak. SMP-114 significantly reduces SR Ca 2+ leak (as assessed by Ca 2+ sparks) in human atrial (0.72 ± 0.33 sparks/100 µm/s vs. control 3.02 ± 0.91 sparks/100 µm/s) and failing left ventricular (0.78 ± 0.23 vs. 1.69 ± 0.27 sparks/100 µm/s) as well as in murine ventricular cardiomyocytes (0.30 ± 0.07 vs. 1.50 ± 0.28 sparks/100 µm/s). Associated with lower SR Ca 2+ leak, we found that SMP-114 suppressed the occurrence of spontaneous arrhythmogenic spontaneous Ca 2+ release (0.356 ± 0.109 vs. 0.927 ± 0.216 events per 30 s stimulation cessation). In consequence, post-rest potentiation of Ca 2+ -transient amplitude (measured using Fura-2) during the 30 s pause was improved by SMP-114 (52 ± 5 vs. 37 ± 4%). Noteworthy, SMP-114 has these beneficial effects without negatively impairing global excitation-contraction coupling: neither systolic Ca 2+ release nor single cell contractility was compromised, and also SR Ca 2+ reuptake, in line with resulting cardiomyocyte relaxation, was not impaired by SMP-114 in our assays. SMP-114 demonstrated potential to treat SR Ca 2+ leak and consequently proarrhythmogenic events in rodent as well as in human atrial cardiomyocytes and cardiomyocytes from patients with heart failure. Further research is necessary towards clinical use in cardiac disease.

PENERAPAN MODEL PEMBELAJARAN NUMBER HEADS TOGETHER (NHT UNTUK MENINGKATKAN HASIL BELAJAR SISWA KELAS VIIA SMP NEGERI 2 TUNTANG PADA MATERI SEGITIGA

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Era Destiyandani

2016-12-01

Full Text Available Penelitian tindakan kelas ini bertujuan untuk meningkatkan hasil belajar dan mendeskripsikan kondisi siswa kelas VIIA SMP Negeri 2 Tuntang pada materi segitiga melalui penerapan model pembelajaran Number Heads Together (NHT. Melalui model pembelajaran NHT, tugas diberikan kepada semua siswa dimana siswa telah diberi nomor berbeda didalam kelompoknya namun masing-masing kelompok menggunakan penomoran yang sama. Pemanggilan nomor siswa secara acak untuk melaporkan hasil diskusi kelompok mendorong setiap siswa secara individu bertanggung jawab atas hasil belajarnya. Instrumen penelitian yang digunakan untuk mengambil data penelitian adalah soal tes dan lembar observasi. Penelitian ini diterapkan pada 31 siswa sebagai subjek dan menggunakan model spiral Kemmis dan McTaggart. Hasil penelitian menunjukkan bahwa persentase ketuntasan siswa untuk materi segitiga tentang mengidentifikasi sifat-sifat segitiga berdasarkan sisi dan sudutnya pada siklus I mencapai 87,1% tuntas dan ketuntasan meningkat menjadi 96,77% pada siklus II dengan materi pembelajaran menghitung keliling dan luas segitiga. Hasil ini menunjukkan bahwa penggunaan model pembelajaran NHT telah meningkatkan penguasaan materi segitiga oleh siswa.

ANALISIS KEBUTUHAN UNTUK PENGEMBANGAN MODUL INKUIRI BERBASIS PERTANYAAN (MIBP DI SMP

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Desak Made Citrawathi

2016-08-01

Full Text Available melakukan analisis kebutuhan untuk pengembangan dan penyusunan modul inkuri berbasis pertanyaan (MIBP. MIBP disusun untuk memfasilitasi pembelajaran sains agar dapat meningkatkan penguasaan konsep biologi, keterampilan proses sains, dan kemampuan berpikir siswa SMP. Pengembangan MIBP menggunakan model ADDIE. Prosedur pengembangan terdiri dari 5 tahap, yaitu 1 Menganalisis, 2 Mendisain, 3 Mengembangkan dan produksi, 4 Mengimplementasikan, dan 5 Mengevaluasi. Penelitian dilakukan dalam waktu 3 tahun. Pada tahun pertama ini dilakukan analisis kebutuhan dan mendisain MIBP. Subjek penelitian adalah guru IPA SMP Negeri dan Swasta di Kecamatan Buleleng. Pengumpulan data dilakukan dengan wawancara, penyebaran angket, observasi, dan dokumentasi. Analisis data dilakukan secara deskriptif dan interpretatif. Dari hasil analisis diperoleh bahwa kurikulum yang digunakan di SMPN 1,SMPN 2, dan SMPN 4 adalah kurikulum 2013, sedangkan di SMP lainnya masih menggunakan kurikulum 2006. Kemampuan guru bertanya untuk meningkatkan keterampilan proses sains, penguasaan konsep, dan kemampuan berpikir belum optimal. Hal ini ditunjukkan dari jenis pertanyaan yang diajukan guru 85,8 persen bersifat konvergen, dan 14,2 persen bersifat divergen. Berdasarkan pertanyaan menurut Taksonomi Bloom, pertanyaan yang diajukan guru 74,4 persen pertanyaan ingatan, 22,6 persen pemahaman, 2,68 persen aplikasi, dan 0,32 persen analisis. Salah satu yang dapat dilakukan untuk meningkatkan kemampuan guru adalah memfasilitasi pembelajarannya dengan MIBP. Dari karakteristik perkembangan kognitifnya, siswa SMP dapat dibelajarkan dengan strategi inkuiri, dan guru setuju dengan pengembangan MIBP. Kata kunci: Kemampuan berpikir, keterampilan proses sains, Modul Inkuiri Berbasis Pertanyaan, penguasaan konsep Pertanyaan, penguasaan konsep Abstract The purpose of this study was to analyze the need for the development and preparation of question-based inquiry module (QBIM. QBIM was designed conceiv to

Décadas de oro de la centenaria SMP

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Duque Escobar, Gonzalo

2012-01-01

Aportes de la SMP hasta el Centenario de Manizales, de este espacio cívico creado en 1912 cuando Aquilino Villegas y Alfonso Robledo convocan a notables ciudadanos de la próspera aldea, como Alfonso Villegas, Carlos E. Pinzón, Constantino Gutiérrez, Estanislao Estrada, Fernando Arango, Francisco Gutiérrez, Gonzalo Villegas, Jesús María Arias, Liborio Gutiérrez, Luis Londoño, Pedro Henao y Pompilio Gutiérrez.

Comparison of Established Diagnostic Methodologies and a Novel Bacterial smpB Real-Time PCR Assay for Specific Detection of Haemophilus influenzae Isolates Associated with Respiratory Tract Infections.

Science.gov (United States)

Reddington, Kate; Schwenk, Stefan; Tuite, Nina; Platt, Gareth; Davar, Danesh; Coughlan, Helena; Personne, Yoann; Gant, Vanya; Enne, Virve I; Zumla, Alimuddin; Barry, Thomas

2015-09-01

Haemophilus influenzae is a significant causative agent of respiratory tract infections (RTI) worldwide. The development of a rapid H. influenzae diagnostic assay that would allow for the implementation of infection control measures and also improve antimicrobial stewardship for patients is required. A number of nucleic acid diagnostics approaches that detect H. influenzae in RTIs have been described in the literature; however, there are reported specificity and sensitivity limitations for these assays. In this study, a novel real-time PCR diagnostic assay targeting the smpB gene was designed to detect all serogroups of H. influenzae. The assay was validated using a panel of well-characterized Haemophilus spp. Subsequently, 44 Haemophilus clinical isolates were collected, and 36 isolates were identified as H. influenzae using a gold standard methodology that combined the results of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and a fucK diagnostic assay. Using the novel smpB diagnostic assay, 100% concordance was observed with the gold standard, demonstrating a sensitivity of 100% (95% confidence interval [CI], 90.26% to 100.00%) and a specificity of 100% (95% CI, 63.06% to 100.00%) when used on clinical isolates. To demonstrate the clinical utility of the diagnostic assay presented, a panel of lower RTI samples (n = 98) were blindly tested with the gold standard and smpB diagnostic assays. The results generated were concordant for 94/98 samples tested, demonstrating a sensitivity of 90.91% (95% CI, 78.33% to 97.47%) and a specificity of 100% (95% CI, 93.40% to 100.00%) for the novel smpB assay when used directly on respiratory specimens. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

THE APPLICATION OF RECIPROCAL TEACHING METHOD FOR IMPROVING THE UNDERSTANDING OF MATHEMATICS CONCEPT OF 7TH GRADE STUDENTS SMP NEGERI 2 DEPOK.

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Tatag Bagus Argikas

2016-10-01

Full Text Available This research aims to: (1 describe the implementation of learning mathematics with Reciprocal Teaching methods that is for improving the concept of learning understanding mathematic in class VIIA SMP Negeri 2 Depok. (2 Knowing the increased understanding of student learning in class VIIA SMP Negeri 2 Depok use Reciprocal Teaching methods. This research constitutes an action in class that is according along the teacher. The data of research was collated by sheet observations and each evaluation of cycles. That is done in two cycles. The first was retrieved the average value of student learning achievement of 70.96%. The second was retrieved achievement of 90.32%. Thus this learning model can increase student learning understanding.   Key word: The understanding of Mathematical Concept, Reciprocal Teaching Method.

The Implementation of Scaffolding in Writing Recount Texts in SMP Joannes Bosco Yogyakarta

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Tiara Maria Dewi

2017-01-01

Full Text Available In this research, scaffolding is implemented in English class of the 8th grade students of SMP Joannes Bosco Yogyakarta when they learn about recount text. This research aims to find out the process of how scaffolding is implemented and to know what the benefits of scaffolding in writing recount text. There were two research problems. The first was “How is scaffolding for the 8th grade students of SMP Joannes Bosco in writing a recount text?” and the second was “What are the benefits of scaffolding in writing a recount text in SMP Joannes Bosco Yogyakarta?” The writers conducted a descriptive qualitative research in this study. The data was gathered by interviewing the English teacher, writing on the field notes, distributing the questionnaires, and interviewing the students. Analyzing the students’ writings was used as the supplementary data to make the result stronger. The result of this study showed that the implementation of scaffolding gave benefits for the students. The benefits were challenging the students through deep learning and discovery, engaging the students in meaningful and dynamic discussions in the small and the large classes, and motivating the learners to become better students. In conclusion, scaffolding does give benefits for the students so that teachers are able to use scaffolding as one of the effective teaching techniques.   DOI: https://doi.org/10.24071/llt.2016.190104

Global Systems-Level Analysis of Hfq and SmpB Deletion Mutants in Salmonella: Implications for Virulence and Global Protein Translation

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Ansong, Charles; Yoon, Hyunjin; Porwollik, Steffen; Mottaz-Brewer, Heather; Petritis, Brianne O.; Jaitly, Navdeep; Adkins, Joshua N.; Mcclelland, Michael; Heffron, Fred; Smith, Richard D.

2009-03-11

In recent years the profound importance of sRNA-mediated translational/post-transcriptional regulation has been increasingly appreciated. However, the global role played by translational regulation in control of gene expression has never been elucidated in any organism for the simple reason that global proteomics methods required to accurately characterize post-transcriptional processes and the knowledge of translational control mechanisms have only become available within the last few years. The proteins Hfq and SmpB are essential for the biological activity of a range of regulatory sRNAs and thus provide a means to identify potential targets of sRNA regulation. We performed a sample-matched global proteomics and transcriptional analysis to examine the role of Hfq and SmpB in global protein translation and virulence using the Salmonella typhimurium model system. Samples were analyzed from bacteria grown under four different conditions; two laboratory conditions and two that are thought to mimic the intracellular environment. We show that mutants of hfq and smpB directly or indirectly modulate at least 20% and 4% of all Salmonella proteins, respectively, with limited correlation between transcription and protein expression. This is the first report suggesting that SmpB could be a general translational regulator. The broad spectrum of proteins modulated by Hfq was also surprising including central metabolism, LPS biosynthesis, two-component regulatory systems, quorum sensing, SP1-TTSS, oxidative stress, fatty acid metabolism, nucleoside and nucleotide metabolism, envelope stress, aminoacyl-tRNA synthetases, amino acid biosynthesis, peptide transport, and motility.. The extent of global regulation of translation by Hfq is unexpected, with profound effects in all stages of Salmonella’s life cycle. Our results represent the first global systems-level analysis of translational regulation; the elucidated potential targets of sRNA regulation from our analysis will

How the Inductive Voltage Adder (IVA) output impedance affects impedance dynamics of a Self-Magnetic Pinch (SMP) diode

Science.gov (United States)

Renk, Timothy; Simpson, Sean; Webb, Timothy; Mazarakis, Michael; Kiefer, Mark

2016-10-01

The SMP diode, fielded on the RITS-6 (3.5-8.5 MV) IVA accelerator at Sandia National Laboratories, produces a focused electron beam (transmission line (MITL) center conductors, of 40 and 80 ohms flow impedance. We have operated in-situ heating and discharge-cleaning hardware in the load region, in order to address the tendency of some shots to undergo premature impedance (Z) collapse, defined as a fall in impedance beyond that due to normal movement of electrode plasmas that reduces the effective A-K gap. The goal of heating/cleaning was to reduce the volume of evolving gases near the A-K gap. Despite clear evidence that the cleaning techniques removed the proton portion of beam current, we observed no consistent increase in diode impedance (ZDIODE). This forced an examination of the role that the IVA flow impedance has on ZDIODE. A preliminary conclusion is that ZDIODE should be at least 1.5 times the flow impedance before ZDIODE is a parameter independent of flow impedance. This has implications for SMP as a load for a IVA, since ZDIODE >100 ohms has not been consistently demonstrated. Data analysis is ongoing, and latest results will be reported. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

Profil Problem Emosi/ Perilaku Pada Remaja Pelajar SMP-SMA Di Kota Semarang

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Annastasia Ediati

2015-10-01

Full Text Available The aims of this study is to identify the profile of emotional/behavioral problems on adolescents students of junior and senior high school (SMP-SMA in Semarang, Central Java. The subjects comprised 568 students (grade VII and X; males and females, aged between 13-17 years. Data were collected using the Indonesian translation of the Youth Self Report (YSR. The results of data analysis showed that adolescents in the junior high school/SMP reported emotional/behavioral problems more frequently than the adolescents in the senior high school/SMA (t (566 = 2.08, p = .038, especially in terms of social relations (t (566 = 2.92, p = .004, thought problems (t (566 = 2.47, p = .014, somatic complaints (t(566 = 2.98, p = .002, rule-breaking behavior (t (566 = 6.63, p < .001, and externalizing problems (t(566 = 3,37; p = .001. Gender differences was found in the adolescents’ emotional/behavioral problems. In group of junior high school students (SMP, girls reported more emotional problems than boys (t(335 = -3.55; p < .001, particularly in anxiety/depression (t(335 = -6.51; p < .001; withdrawal (t(335 = -4.26; p < .001, somatic complaints (t(335 = -2.86; p = .004; social problems (t(335 = -3.30; p = .001, attention problems (t(335 = -2.39; p = .017; and internalizing problem (t(335 = -5.76; p < .001. In group of senior high school students (SMA, boys reported more externalizing problems (t(229 = 2.10; p = .037 and rule-breaking behavior (t(229 = 4.44; p < .001 than girls. In contrasts, girls reported more somatic complaints than boys (t(229 = -3.09; p = .001. Adolescents’ emotional/behavioral problems should gained more attention. Preventive as well as curative intervention is needed, particularly intervention that sensitive to gender and age, which also involve significant figures for adolescents (parents, school teachers, and peers.

EFEKTIVITAS BAHAN AJAR IPA TERPADU TERHADAP KEMAMPUAN BERPIKIR TINGKAT TINGGI SISWA SMP

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L. Yuliati

2013-01-01

Full Text Available Penelitian ini bertujuan untuk menguji efektivitas bahan ajar IPA terpadu untuk SMP, khususnya tema Air Limbah Rumah Tangga. Desain penelitian menggunakan kuasi-eksperimen dengan Pretest-Postest Control Group Design. Penelitian dilaksanakan di SMPN 20 Malang kelas VII. Sampel ditetapkan dengan purposive sampling. Perlakuan pada kelompok eksperimen adalah pembelajaran yang menggunakan bahan ajar IPA terpadu, sedangkan kelompok kontrol  menggunakan buku  sekolah elektronik (BSE. Instrumen yang digunakan adalah butir soal tes, lembar observasi pembelajaran, dan perangkat  pembelajaran. Analisis data dilakukan dengan Anava AB untuk uji perbedaan rerata dan uji scheffe untuk uji efektivitas bahan ajar. Hasil penelitian menunjukkan bahwa terdapat perbedaan kemampuan berpikir tingkat tinggi pada siswa SMP yang menggunakan bahan ajar IPA Terpadu dengan siswa SMP yang menggunakan bahan ajar IPA yang terpisah bidang kajiannya, dan bahan ajar IPA terpadu efektif untuk meningkatkan kemampuan berpikir tingkat tinggi siswa. This study aims totest the effectiveness of an integrated science teaching materials for students of junior high school, particularly in themeof Domestic Wastewater. The study designused a quasi-experimental pretest-posttest with control group design. The experiment was conductedin Junior High School of Malang. Samples were determined by purposive sampling. Treatmentin the experimental group was learning to integrated science teaching materials, whereas in the control group with the teaching materials available in schools. The instrument used were a matter oftestitems, observation sheets of learning, and learningtools. Data analysis was performed with AnovaAB totestmean difference and Scheffetesttotestthe effectiveness ofinstructional materials. The results showed that 1there aredifferences inhigher-order thinkingskillsinjunior high school students using teaching materials in integrated science withjunior high school students

Penggunaan Media Presentase Microsoft Power Point Untuk Meningkatkan Hasil Belajar IPS Terpadu Pada Siswa Kelas VIII a SMP Negeri 2 Tanantovea

OpenAIRE

Hitler, Ahmad

2014-01-01

Permasalahan yang diangkat dalam penelitian adalah apakah dengan penggunaan media Presentase Microsoft Power Point pada mata pembelajaran IPS Terpadu dapat meningkatkan hasil belajar siswa kelas VIII A di SMP Negeri 2 Tanantovea. Penelitian ini bertujuan untuk meningkatkan hasil belajar siswa pada pokok bahasan Kolonialisme dan Imperialisme Barat di kelas VIII A SMP Negeri 2 Tanantovea. Penelitian ini dilakukan dalam 2 siklus, setiap siklus terdiri dari perencanaan, pelaksanaan tindakan, obs...

Profil Merokok pada Pelajar di Tiga SMP di Kota Padang

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Yessy Susanti Sabti

2015-09-01

Full Text Available Abstrak   Merokok merupakan kontributor utama kematian.  Jumlah perokok semakin meningkat di seluruh dunia dan sebagian besar berada dinegara berkembang, termasuk Indonesia. Sebagai negara dengan perokok terbanyak ketiga di dunia, prevalensi perokok remaja di Indonesia semakin meningkat setiap tahun. Dengan menggunakan kuesionerGlobal Youth Tobacco Survey, kami meneliti profil merokok pada pelajar di tida SMP di kota Padang. Desain peneitian adalah crossectional. Data diperoleh dari kuesioner Global Youth Tobacco Survey, berbahasa Indonesia. Didapatkan sampel 240  murid dari 3 SMP dipilih secara acak di Kota Padang. Hasil : 27,7% murid pernah merokok, dan semuanya adalah laki-laki. 29%  mencoba rokok pada usia kurang dari 10 tahun. 37%  murid masih merokok sampai sekarang, 46% diantaranya sudah ketagihan rokok. Sebanyak 77,1% murid yang pernah merokok mempunyai orang tua perokok. Sebagian besar dari total sampel terpapar asap rokok lingkungan baik di rumah dan di tempat-tempat umum. Kesimpulan: Lebih dari seperempat pelajar di tiga SMP di kota Padang pernah merokok dan semuanya laki laki, dan mencoba merokok padausia kurang dari 10 tahun. Hampir seperlima sudah ketagihan merokok.Kata kunci: Pelajar, Merokok, Global Youth Tobacco SurveyAbstract Smoking is the mayor contibutor of death, and the number of smoker is growing overworld. More of them live in the developing country, including Indonesia. As the third of most smoker number, the teenager smoker prevalence in Indonesia is increase over year. By using Indonesian language adapted of Global Youth Tobacco Survey quessionaires, we researched smoking teenager behaviour and realted factors at Junior High School of Padang. Design of study is crossectional, datas collected from 240 students of three randomized selected Junior High School, by  Global Youth Tobacco Survey quessionaires that has adapted to Indonesian language. Results : 27,7% of students reported that they ever smoked cigarettes

FAKTOR-FAKTOR YANG MEMPENGARUHI KESULITAN BELAJAR IPS TERPADU KELAS VII DI SMP NEGERI 1 PLANTUNGAN KABUPATEN KENDAL

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Lina Maftukhah,

2012-10-01

Full Text Available Kesulitan belajar dipengaruhi oleh berbagai macam faktor, baik faktor intern maupun faktor ekstern. Berdasarkan hasil observasi dari data nilai UAS IPS Terpadu sebagian besar siswa kelas VII SMP Negeri 1 Plantungan mendapat nilai rendah dan menyebabkan tidak lulus KKM. Hal ini dapat dijadikan indikasi bahwa siswa mengalami kesulitan belajar IPS Terpadu. Permasalahan yang dikaji dalam penelitian ini adalah apa saja faktor-faktor yang mempengaruhi kesulitan belajar mata pelajaran IPS Terpadu Siswa Kelas VII dan faktor apakah yang lebih dominan mempengaruhi kesulitan belajar mata pelajaran IPS Terpadu Siswa Kelas VII SMP Negeri 1 Plantungan Kabupaten Kendal Tahun Ajaran 2011/2012. Penelitian ini bertujuan untuk mengetahui faktor-faktor apa saja yang mempengaruhi kesulitan belajar mata pelajaran IPS Terpadu dan faktor apakah yang lebih dominan mempengaruhi kesulitan belajar mata pelajaran IPS Terpadu. Penelitian ini dilakukan di SMP N egeri 1 Plantungan Kabupaten Kendal. Populasi penelitian ini adalah siswa kelas VII sebanyak 131 siswa. Pengambilan sampel dilakukan secara proposional claster random sampling dan didapat sampel sebanyak 100 siswa. Variabel dalam penelitian ini adalah faktor-faktor yang mempengaruhi kesulitan belajar IPS Terpadu kelas VII SMP Negeri 1 Plantungan Kabupaten Kendal. Metode pengumpulan data yang digunakan adalah metode kuesioner dan dokumentasi. Sedangkan untuk analisis data yang digunakan adalah analisis faktor dan deskriptif persentase. Berdasarkan analisis faktor terdapat 5 komponen yang akan membentuk 5 faktor baru. Adapun tingkat kesulitan belajar siswa dari 5 faktor baru berdasarkan uji Deskripsi Persentase sebagai berikut : (a kemampuan siswa 61,55%, (b kemampuan guru 66,75%, (c sarana penunjang 77,00%, (d dukungan sekolah 72,67%, (e dukungan keluarga 62,00%. Dari kelima faktor yang ada, faktor kemampuan siswa merupakan pengaruh yang paling dominan dengan koefisien varian sebesar 61,55% dengan kategori menghambat

Contribution of the backstreaming ions to the self-magnetic pinch (SMP) diode current

Science.gov (United States)

Mazarakis, Michael G.; Bennett, Nichelle; Cuneo, Michael E.; Fournier, Sean D.; Johnston, Mark D.; Kiefer, Mark L.; Leckbee, Joshua J.; Nielsen, Dan S.; Oliver, Bryan V.; Sceiford, Matthew E.; Simpson, Sean C.; Renk, Timothy J.; Ruiz, Carlos L.; Webb, Timothy J.; Ziska, Derek; Droemer, Darryl W.; Gignac, Raymond E.; Obregon, Robert J.; Wilkins, Frank L.; Welch, Dale R.

2018-04-01

The results presented here were obtained with a self-magnetic pinch (SMP) diode mounted at the front high voltage end of the RITS accelerator. RITS is a Self-Magnetically Insulated Transmission Line (MITL) voltage adder that adds the voltage pulse of six 1.3 MV inductively insulated cavities. The RITS driver together with the SMP diode has produced x-ray spots of the order of 1 mm in diameter and doses adequate for the radiographic imaging of high area density objects. Although, through the years, a number of different types of radiographic electron diodes have been utilized with SABER, HERMES III and RITS accelerators, the SMP diode appears to be the most successful and simplest diode for the radiographic investigation of various objects. Our experiments had two objectives: first to measure the contribution of the back-streaming ion currents emitted from the anode target and second to try to evaluate the energy of those ions and hence the Anode-Cathode (A-K) gap actual voltage. In any very high voltage inductive voltage adder utilizing MITLs to transmit the power to the diode load, the precise knowledge of the accelerating voltage applied on the A-K gap is problematic. This is even more difficult in an SMP diode where the A-K gap is very small (˜1 cm) and the diode region very hostile. The accelerating voltage quoted in the literature is from estimates based on the measurements of the anode and cathode currents of the MITL far upstream from the diode and utilizing the para-potential flow theories and inductive corrections. Thus, it would be interesting to have another independent measurement to evaluate the A-K voltage. The diode's anode is made of a number of high-Z metals in order to produce copious and energetic flash x-rays. It was established experimentally that the back-streaming ion currents are a strong function of the anode materials and their stage of cleanness. We have measured the back-streaming ion currents emitted from the anode and propagating

Analisis Tingkat Kebisingan Di Area SMP Neg.6 Makassar Berbasis Persepsi

OpenAIRE

Sultan, Yoventus

2016-01-01

Penelitian ini dilaksanakan di SMPN 6 Makassar yang berada di jalan Jend. Ahmad Yani. Penelitian ini bertujuan menganalisis persepsi civitas dan warga di SMP 6 terhadap upaya pengendaloan kebisingan. Selain itu, penelitian ini juga bertujuan untuk menganalisis hubungan antara pekerjaan dan persepsi tingkat kebisingan di SMPN 6 Makassar. Peneliti mengumpulkan data dengan cara penyebaran kuisioner sebagai metode yang digunakan dalam penelitian ini kepada civitas sekolah dan warga sekitar sekol...

[Adaptation and validation of the SMP-T2D questionnaire in Spanish for evaluating self-management of high blood pressure and type 2 diabetes: PAG-DT2+HTA].

Science.gov (United States)

Galván Flores, G M; Gallegos Carrillo, K; Palomo Piñon, S; Sánchez García, S; Cuadros Moreno, J; Martínez Olivares, M V; Cuevas Cancino, J J; Grijalva, I; Sánchez Arenas, R

High blood pressure is one of the most common chronic conditions worldwide. It affects one in every 3 adults over 40, while one in 10 suffers from diabetes. For both diseases, adherence to pharmacological treatment is over 30%, and self-management, which takes into account diet and physical activity, is still unknown, as there is no tool available to measure self-management. Therefore, the object of this study was to adapt and validate the Spanish version of the self-management profile for type 2 diabetes (SMP-T2D) questionnaire in patients with type 2 diabetes and high blood pressure among users of first level care in the social security institution of Mexico. The SMP-T2D was adapted to Spanish by translation into Spanish, and being used only in patients with high blood pressure and type 2 diabetes-hypertension. A convergent and discriminatory validation was performed. Patients over 50 years old with high blood pressure were include. Those that did not complete the questionnaire or give informed consent were rejected. The Spanish version of the SMP-T2D was called PAG-DT2+HTA, and was applied to 145 people with hypertension: 54.4% with hypertension only, and 43.6% with hypertension and type 2 diabetes. Mean age was 66.14 years (SD=10.78), with 34.7% women and 65.3% men. Internal consistency by α-Cronbach for the questionnaire was 0.561 (P=.000). The correlation between the PAG-DT2+HTA and Morisky-Green was significant. The ability to discriminate between people with and without education and with and without economic means was obtained. The Spanish version of SMP-T2D (PAG-DT2+HTA) that measures self-management in type 2 diabetes, can be used to measure self-management in people with type 2 diabetes-hypertension. Copyright © 2017 SEH-LELHA. Publicado por Elsevier España, S.L.U. All rights reserved.

Meningkatkan Prestasi Belajar Siswa Kelas VIII.F SMP Negeri 33 Surabaya Pada Mata Pelajaran IPS Materi Pranata Sosial Dengan Model Pembelajaran Snowball Throwing

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Mudjianingsih Mudjianingsih

2017-01-01

                      Asks activities in social studies is an important part in carrying out the study, which asks activities serve to gather information from students, to confirm what was already known, and to bring attention to the aspect of the unknown. Based on observations in the classroom conditions VIII F SMP Negeri 33 Surabaya Surabaya are less enthusiastic in asking questions the need for action using the appropriate learning models, one model of learning that can improve student learning outcomes is learning models Snowball Throwing. In this research there are four research purposes, the fourth such purposes include: 1 To determine the application of learning models Snowball Throwing, 2 To determine activity students 3 To determine student learning outcomes, and 3 To know the constraints and solutions in applying learning models Snowball Throwing.                     This study was a classroom action research (PTK with a qualitative approach in the classroom VIII F SMP Negeri 33 Surabaya Surabaya, which amounted to 32 students. In the application of Snowball Throwing consisting of two cycles, each cycle consisting of the planning stage, the stage of action, observation and reflection stages. Data collection techniques interest asked in this study using observation sheet interest to ask, and for student learning outcomes using the test cycle I and II. Data analysis using data reduction, observation data, and drawing conclusions. The results of this study show that: 1 Application of Learning Model Throwing Snowball carried out with 2 cycles, with each cycle consisting of the planning phase, the implementation phase, observation and reflection phase, 2 Complete test results of students in the first cycle was 68.42% , to test cycle II completeness increased to 100%, completeness criteria in this second cycle in the category Very Good, 3 constraints experienced researchers, among others: the seriousness of the students

The SMP mobilizes a bright idea: a CSM cinema on wheels.

Science.gov (United States)

1985-01-01

The Bangladesh Family Planning Social Marketing Project (SMP) provides 1 of the best examples of the use of the mass media to promote social marketing. Using a fleet of 7 vans and 1 motor launch, the SMP brings films about family planning to more than a million rural couples a month living in isolated villages. Each film unit has two 16 mm projectors, a generator, a screen and speaker system and is operated by a projectionist and an assistant. 1 mobile unit gives about 25 shows a month at a cost of $75US per show, or less than 2 cents per person. The message reels and advertising spots were produced in Bangladesh, and the musical numbers are taken from local feature films. Every 3-4 months, the vans switch message and musical films, but all units keep separate copies of the advertising spots for Raja and Panther condoms and Maya and Ovacon pills. The motivational films were developed through extensive research, and they address basic social issues. During the show, various promotional items are sold, including calendars with family planning messages, plastic bags, key rings, and contraceptives. According to Robert Ciszewski, executive director of Population Services International, these mobile films are making a profound social change in Bangladesh.

78 FR 21610 - Expansion Funds for the Support of the Senior Medicare Patrol (SMP) Program

Science.gov (United States)

2013-04-11

... Grants. Announcement Type: Health Care Fraud Prevention Program Expansion Capacity. Funding Opportunity... DEPARTMENT OF HEALTH AND HUMAN SERVICES Administration for Community Living Expansion Funds for the Support of the Senior Medicare Patrol (SMP) Program ACTION: Notice of intent to provide expansion...

PENGEMBANGAN MODEL PEMBELAJARAN BERBASIS MULTIMEDIA INTERAKTIF PENGUKURAN UNTUK MENINGKATKAN HASIL DAN KEMANDIRIAN BELAJAR SISWA SMP DI KOTA BANDUNG

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Erman Sutarno

2015-02-01

and the students can easily check their own progress, (5 every segment of this model was completed with reinforcement to improve the learning quality. Keywords: Learning Model, Interactive Multimedia, Experiential Learning Cycle. ABSTRAK Penelitian ini bertujuan untuk menghasilkan model pembelajaran Pengukuran berbasis multimedia interaktif  yang dapat meningkatkan hasil dan kemandirian belajar siswa di SMP kelas VII. Penelitian dilaksanakan di SMP di Kota Bandung menggunakan pendekatan research and development. Proses dilaksanakan melalui tahapan: studi pendahuluan, pengembangan, dan pengujian. Instrumen yang digunakan pada tahap studi pendahuluan adalah studi pustaka dan survei lapangan; tahap pengembangan model dilakukan berupa penyusunan draf awal model, uji-coba terbatas, dan uji-coba diperluas; tahap validasi model berupa eksperimen pre-test treatment post-test dengan menggunakan matching pretest-posttest control group design. Penelitian ini menggunakan profil model pembelajaran experiential learning cycle dari teori belajar Kolb (1994 dengan karakteristik: (1 mengintegrasikan pengalaman awal siswa dengan pengalaman scientific (ilmiah, (2 belajar sambil bekerja (work-base laboratory, (3 pendidikan yang bersifat kooperatif (bekerja sama dalam konteks sosial, dan (4 menjamin penguasaan kompetensi dasar pengukuran arus, meter, kilogram yang memadai. Hasil uji efektivitas melalui model pembelajaran berbasis multimedia interaktif  dapat meningkatkan hasil belajar dan kemandirian belajar siswa. Beberapa temuan terpenting adalah: (1 model ini dapat meningkatkan kompetensi belajar siswa pada ranah kognitif, (2 melalui perangkat lunak keterampilan siswa dapat meningkatkan kemampuan bekerjasama dalam kelompok belajar, melatih berfikir kreatif, dan berkomunikasi, (3 mampu menerapkan berbagai kemampuan dengan terampil ketika mengerjakan LKS. Beberapa rekomendasi penelitian untuk guru, sekolah, pemerintah adalah: (1 Multimedia interaktif melalui animasi yang didisain

Optimalisasi Prestasi Belajar Materi Elektromagnet dengan Menggunakan Pendekatan Eksperimen dalam Pembelajaran IPA pada Peserta Didik Kelas IX A SMP Negeri 3 Teras Semester Gasal Kabupaten Boyolali Tahun Pelajaran 2011/2012

OpenAIRE

Budiharjo Budiharjo

2015-01-01

This research purpose is to describe about effort to increase learning achievement giving task autonomous structure in learning electromagnet material of the student’s class IX A SMP Negeri 3 Teras Boyolali regency semester 2011/2012. Subject and data source of the research the students class IX A sum 40 students. Collecting data method uses observation, documentation and test. Analysis data uses critic and comparative. Reaching indicator uses KKM 63 and complete target 100%. Research procedu...

Pengembangan Perangkat Pembelajaran Matematika Berbasis Concept Attainment Model (CAM untuk Peserta Didik Kelas VIII SMP

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Eka Jihadah Syaspasbandah

2018-01-01

Full Text Available Penelitian ini merupakan penelitian pengembangan yang bertujuan untuk menghasilkan perangkat pembelajaran matematika berbasis Concept Attainment Model (CAM yang valid, praktis, dan efektif terhadap hasil belajar dan aktivitas peserta didik SMP kelas VIII. Perangkat pembelajaran yang dikembangkan mengikuti prosedur pengembangan Model Plomp yang terdiri dari 3 tahap, yaitu tahap analisis pendahuluan, tahap pengembangan atau pembuatan prototipe, dan tahap penilaian. Uji validitas perangkat pembelajaran dilakukan oleh lima orang ahli dari bidang matematika, teknologi pendidikan, dan bahasa Indonesia. Pengujian kepraktisan perangkat pembelajaran diukur dari tiga hal yaitu: keterlaksanaan perangkat pembelajaran, respon peserta didik, dan respon guru. Untuk menilai efektifitas perangkat pembelajaran, dilakukan dengan mengumpulkan data melalui pengamatan terhadap aktivitas belajar matematika peserta didik selama kegiatan pembelajaran dan nilai tes hasil belajar matematika peserta didik. Hasil pegujian tersebut mengidentifikasi bahwa perangkat pembelajaran matematika berbasis CAM yang dikembangkan dinyatakan valid menurut para ahli, praktis berdasarkan guru dan peserta didik sebagai pengguna, dan efektif terlihat dari aktivitas peserta didik selama proses pembelajaran yang mengalami peningkatan. Kata kunci: penelitian pengembangan, Concept Attainment Model, hasil belajar, aktivitas belajar, Model Plomp   ABSTRACT This research is development research aims to produces mathematics learning equipment based on valid, practical, and effective CAM for learning outcome and students activity of VIII grade junior high school. The developed learning equipment uses the procedure of Plomp Model that consists of 3 stages, they are preliminary research, development or prototyping phase, and assessment phase. Validity test of learning equipment is done by 5 experts from mathematics, eduaction technology, and indonesian language. Practical learning equipment test is

PREVALENSI DAN KARAKTERISTIK PELAYANAN VAKSINASI CERVARIX SEBAGAI PREVENSI PRIMER KANKER SERVIKS DI SMP NEGERI 1 DENPASAR PERIODE OKTOBER 2011 - APRIL 2012

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Hendrikus Gede Surya Adhi Putra

2015-07-01

Full Text Available Vaksin Human Papillomavirus (HPV saat ini menjadi metode pencegahan yang paling diperhitungkan terhadap infeksi HPV yang merupakan etiologi kanker cervix. Peningkatan efektifitas vaksin HPV terjadi pada pemberian dalam rentang usia prapubertas dan remaja. Pemberian vaksin yang menargetkan usia tersebut dapat menjaring wanita yang masih belum aktif secara seksual, sehingga probabilitas terpapar HPV masih rendah. Disamping itu, respon imunitas yang dihasilkan juga lebih besar dibandingkan pemberian pasca pubertas. Tujuan penelitian ini untuk mengetahui prevalensi vaksinasi cervarix sebagai upaya prevensi primer kanker serviks di SMP Negeri 1 Denpasar. Penelitian ini menggunakan metode deskriptif retrospektif dan dilaksanakan di SMP Negeri 1 Denpasar pada tanggal 8 November 2012. Dengan sampel yakni siswi yang mengikuti program vaksinasi HPV cervarix di SMP Negeri 1 Denpasar pada 15 Oktober 2011, 12 November 2011, dan 14 April 2012. Dari penelitian ini diperoleh yang mengikuti program vaksinasi sebanyak 46 siswi dari 420 siswi atau 10,95%. Hasil distribusi yang tertinggi, menurut umur usia 14 tahun (43,48%, kelas IX (17,95%, asal daerah Denpasar (50%, mempunyai 3 saudara kandung (39,13%, pendidikan orang tua sarjana (82,61%, pekerjaan orang tua sebagai PNS (32,61%, penghasilan orang tua diatas 3 juta (45,65%.Berdasarkan  hasil  penelitian  ini,  dapat  disimpulkan  bahwa  kesadaran siswi SMP Negeri 1 Denpasar mengenai vaksin HPV berada dalam kategori rendah. Oleh karena itu, diperlukan sosialisasi yang berkesinambungan untuk memberikan pemahaman dan kesadaran mengenai pentingnya upaya pencegahan primer kanker serviks, yaitu melalui vaksinasi.

Paket Layanan Informasi Karir untuk Meningkatkan Pemahaman Studi Lanjut Siswa SMP

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Jilvia Indyarti

2014-12-01

Full Text Available Tujuan penelitian ini yaitu  untuk mengetahui keefektifan paket layanan informasi karir berbasis multimedia dalam meningkatkan pemahaman studi lanjut. Jenis penelitian ini adalah penelitian eksperimen. Penelitian ini dilaksanakan di SMP Negeri 1 Majenang dengan sampel siswa kelas VIII. Alat pengumpulan data yang digunakan yaitu angket. Teknik analisis data menggunakan analisis deskriptif persentase dan analisis kuantitatif. Hasil analisis deskriptif persentase diperoleh hasil bahwa pemahaman studi lanjut siswa meningkat sebesar 64%. Analisis kuantitatif menunjukkan bahwa thitung>ttabel sehingga Ho ditolak dan Ha diterima. Berdasarkan hasil penelitian dapat disimpulkan bahwa pemahaman studi lanjut siswa dapat ditingkatkan melalui paket layanan informasi karir berbasis multimedia. The purpose of this study is to determine the effectiveness of packet-based multimedia information services career in improving the understanding of further studies. This research was conducted at SMP Negeri 1 Majenang with sample eighth grade students. Data collection tool used was a questionnaire. Analysis using descriptive analysis and quantitative analysis of the percentage. The results of the descriptive analysis of the percentage of obtained results that further students' understanding of the study increased by 64%. Quantitative analysis showed that tcount> ttable so Ho is rejected and Ha accepted. Based on the results of this study concluded that further study of student understanding can be improved through a packet-based multimedia information service career.

Clinical and Radiographic Outcomes After Submuscular Plating (SMP) of Pediatric Femoral Shaft Fractures.

Science.gov (United States)

Stoneback, Jason W; Carry, Patrick M; Flynn, Katherine; Pan, Zhaoxing; Sink, Ernest L; Miller, Nancy H

2018-03-01

To evaluate lower extremity strength and alignment among children who underwent submuscular plating (SMP). Subjects who underwent SMP for a length unstable femoral fracture returned for isokinetic strength testing ≥2 years after surgery. Extensor and flexor strength deficits (percent difference) between the operative and nonoperative limbs were evaluated. Radiographic measurements of mechanical alignment [anatomic lateral distal femoral angle (aLDFA)] and qualitative measurements (The Pediatric Outcomes Data Collection Instrument, PODCI) were obtained from all subjects. The upper 97.5% confidence interval approach to establishing clinical equivalency was utilized to compare differences in strength and alignment between the operative and nonoperative limbs. An extensor strength deficit of >19% and an aLDFA discrepancy of >5 degrees were considered to be clinically significant. The average age at surgery of the 10 subjects included in the study was 8.7 years. The hardware was placed an average of 27.9 mm from the distal femoral physis and was removed 6.4 months postsurgery. Among all subjects, the median PODCI scores were ≥97 according to all subscales. There was no significant difference in extension torque between the operative versus nonoperative limbs at 60 degrees/s (P=0.5400), 120 degrees/s (P=0.4214), or 180 degrees/s (P=0.8166). More importantly, extension strength deficits between the operative and nonoperative limbs were not clinically significant at 60 degrees/s [upper 97.5% confidence interval (CI), 10.9%], 120 degrees/s (upper 97.5% CI, 11.0%), or 180 degrees/s (upper 97.5% CI, 10.7%). The difference in aLDFA between the operative and nonoperative limb was less than the predefined clinically significant threshold of 5 degrees for all subjects. SMP achieves satisfactory clinical and functional results. In this series, extensor strength deficits and/or lower extremity malalignment were not clinically meaningful. High patient satisfaction can be

PENINGKATAN AKTIVITAS DAN HASIL BELAJAR BENTUK PASAR DENGAN METODE COURSE REVIEW HORAY (CRH BERBANTUAN MEDIA GAMBAR KELAS VIII SMP N 1 BULU KABUPATEN SUKOHARJO

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Setyaningsih Setyaningsih

2013-11-01

Full Text Available Penelitian ini bertujuan untuk meningkatkan aktivitas dan hasil belajar siswa pada materi bentuk pasar dengan metode Course Review Horay (CRH berbantuan media gambar kelas VIII SMP N 1 Bulu Kabupaten Sukoharjo. Jenis penelitian ini adalah penelitian tindakan kelas yang terdiri dari dua siklus. Setiap siklus memiliki empat tahap yaitu perencanaan, pelaksanaan, pengamatan, dan refleksi. Subjek penelitian ini adalah siswa kelas VIIIA SMP N 1 Bulu. Data aktivitas siswa dan guru diperoleh dari lembar observasi. Data hasil belajar diperoleh dari soal evaluasi siklus I dan siklus II. Berdasarkan hasil penelitian diperoleh aktivitas siswa siklus I sebesar 70,83% meningkat menjadi 87,50% pada siklus II. Sedangkan aktivitas guru dalam siklus I sebesar 71,86% meningkat menjadi 90,6% pada siklus II. Rata-rata hasil belajar kognitif menunjukkan pada siklus I sebesar 72,67 meningkat menjadi 83,20 pada siklus II. Sedangkan ketuntasan klasikal pada siklus I sebesar 70% meningkat menjadi 83,33% pada siklus II. Dari hasil penelitian tersebut dapat disimpulkan bahwa terjadi peningkatan aktivitas dan hasil belajar siswa pada materi bentuk pasar dengan metode Course Review Horay (CRH berbantuan media gambar siswa kelas VIIIA SMP N 1 Bulu Kabupaten Sukoharjo. This research is aimed to increasing activity and student learning results in the subject matter of market forms material by using Course Review Horay (CRH method and image as media in VIIIA class of SMP N 1 Bulu. The design is Classroom Action Research (CAR consisting of two cycles, each cycle including planning, action, observation and reflection. The subjects of research were 30 students of the VIIIA class of SMP N 1 Bulu. Student and teacher activity data were obtained from observation sheet. Results learning data were obtained from test evaluation of the first cycle and second cycle. Based on the results research was obtained in the first cycle of student activities at 70,83% increased to 87,50 in the

EFFORTS TO INCREASE THE ABILITY TO CHOOSE A SCHOOL GROUP COUNSELING SERVICES THROUGH ADVANCED CLASS IX SMP NEGERI 2 METRO STATE IN 2013

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Rohima Rohima

2016-06-01

Full Text Available SMP Negeri 2 Metro In reality, there are many confused students choose a major program of advanced studies, especially for junior high school students. It is necessary to learn / coaching to the students to be able to choose the school accordingly. Researchers conduct action research through the Guidance Counseling Group in Class IX student of SMP Negeri 2 Metro. The experiment was conducted using two cycles. Recapitulation of data Selecting a program majoring in the process of learning / coaching from the first cycle to the second cycle, there is an increase of 57.06% to 86.35%. The results of the data summary portfolio also increased from 33.32% to 83.33%, and the recapitulation of learning outcomes of students who otherwise Completed Pass also risen from 54.54% increase to 96.96%. Thus concluded indicator of success is to reach the target / as are 95% or more. Keywords: guidance group, select schools, smp negeri 2 metro

Molecular mechanism and function of CD40/CD40L engagement in the immune system.

Science.gov (United States)

Elgueta, Raul; Benson, Micah J; de Vries, Victor C; Wasiuk, Anna; Guo, Yanxia; Noelle, Randolph J

2009-05-01

During the generation of a successful adaptive immune response, multiple molecular signals are required. A primary signal is the binding of cognate antigen to an antigen receptor expressed by T and B lymphocytes. Multiple secondary signals involve the engagement of costimulatory molecules expressed by T and B lymphocytes with their respective ligands. Because of its essential role in immunity, one of the best characterized of the costimulatory molecules is the receptor CD40. This receptor, a member of the tumor necrosis factor receptor family, is expressed by B cells, professional antigen-presenting cells, as well as non-immune cells and tumors. CD40 binds its ligand CD40L, which is transiently expressed on T cells and other non-immune cells under inflammatory conditions. A wide spectrum of molecular and cellular processes is regulated by CD40 engagement including the initiation and progression of cellular and humoral adaptive immunity. In this review, we describe the downstream signaling pathways initiated by CD40 and overview how CD40 engagement or antagonism modulates humoral and cellular immunity. Lastly, we discuss the role of CD40 as a target in harnessing anti-tumor immunity. This review underscores the essential role CD40 plays in adaptive immunity.

PENGARUH MODEL DAN CARA PENILAIAN TERHADAP HASIL BELAJAR IPA DENGAN MENGONTROL PENGETAHUAN AWAL MATEMATIKA SISWA

OpenAIRE

Rumbalifar, Adam

2018-01-01

This research aims to study the effect of models and how to assess toward science achievement by controlling previous knowledge mathematics of students. This study conducted at SMP Negeri 1, SMP Negeri 2, and SMP Negeri 3 Bula East Seram district with a population of 295 students. This study used a quasi-experimental method 2 X 3 factorial design using the cell mean univariate models with model covariates Analysis (ANCOVA) which variables are: (1) the dependent variable or response variable a...

Desain Didaktis Penalaran Matematis untuk Mengatasi Kesulitan Belajar Siswa SMP pada Luas dan Volume Limas

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Sulistiawati Sulistiawati

2015-12-01

Full Text Available Penelitian ini dilatarbelakangi oleh rendahnya kemampuan penalaran matematis siswa SMP pada materi geometri. Metode penelitian yang digunakan adalah penelitian desain didaktis (didactial design research.  Penelitian diawali dengan studi pendahuluan untuk mendapatkan data kesulitan belajar (learning obstacle yang dilaksanakan di SMP Negeri 29 Bandung kelas IXE sebanyak 35 orang, SMA Negeri 1 Lembang kelas XI IPA2 sebanyak 41 orang, dan STKIP Siliwangi Bandung mahasiswa semester VI sebanyak 49 orang pada tahun pelajaran 2011/2012 semester genap. Selanjutnya, dikembangkan desain didaktis yang diujicobakan terbatas kepada 30 siswa kelas VIII B SMP Assalam Bandung. Dari uji coba terbatas dilakukan analisis untuk menyusun desain didaktis revisi. Hasil dari penelitian ini diantaranya perangkat pembelajaran yang digunakan pada pembelajaran sebelum menggunakan desain didaktis belum dapat menggali kemampuan penalaran matematis, desain didaktis penalaran matematis yang dikembangkan dapat memperkecil gap yang dihadapi siswa, dan siswa memberikan tanggapan positif terhadap desain didaktis yang dikembangkan.The background of this research was the lack of junior high school students’ mathematical reasoning in geometry. This research used Didactical Design Research (DDR method which started by a preliminary study to 35 students of grade IX E Public Junior High School 29 Bandung, 41 students of grade XI Science Program of Senior High School 1 Lembang, and 49 students of Siliwangi College of Education Bandung in semester VI for academic year 2011/2012. The preliminary study was aimed to explore students’ learning obstacles to develep didactical design. The developed didactical design was implemented to 30 students of grade VII B of Assalam Junior High School Bandung. After this implementation the developed didactical design was revised. The results of this research were the learning tools used by previous teacher have not explored mathematical reasoning yet

PENGGUNAAN MODEL PEMBELAJARAN PROBLEM BASED INSTRUCTION (PBI UNTUK MENINGKATKAN KEAKTIFAN DAN HASIL BELAJAR MATEMATIKA SISWA KELAS 9B SEMESTER GASAL TAHUN PELAJARAN 2014/2015 SMP NEGERI 2 TUNTANG - SEMARANG

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Tri Muah

2016-02-01

Full Text Available Penelitian tindakan kelas ini bertujuan untuk meningkatkan keaktifan dan hasil belajar matematika siswa pada materi peluang dengan penerapan model pembelajaran PBI bagi kelas 9B Semester Gasal SMP Negeri 2 Tuntang Kabupaten Semarang. Hasil penelitian kondisi awal menggunakan wawancara, observasi dan analisis butir soal, siswa kelas 9B ini memiliki keaktifan belajar yang kurang, kemudian berdampak pada hasil belajar siswa rendah juga. Berdasarkan kondisi awal tersebut, perlu dilakukan penelitian tindakan kelas untuk meningkatkan keaktifan belajar dan hasil belajar matematika siswa. Penelitian ini merupakan Penelitian Tindakan Kelas (PTK dengan mengetahui model prosedur penelitian yang dikembangkan oleh Kemmis dan Mc Taggart berupa model penelitian yang spiral yang pada umumnya direncanakan terdiri dari dua siklus. Setiap siklus terdiri dari empat tahap yaitu: 1 tahap pelaksanaan tindakan (planning, 2 tahap pelaksanaan tindakan (acting, 3 tahap pengamatan (observing, dan 4 tahap refleksi (reflecting. Subjek penelitian ini adalah siswa kelas 9B SMP Negeri 2 Tuntang yang terdiri dari 32 orang siswa. Data diperoleh melalui tes kognitif dan lembar observasi siswa. Dari hasil penelitian ini dapat disimpulkan bahwa model pembelajaran PBI dapat meningkatkan keaktifan belajar dan hasil belajar matematika siswa. Hal ini ditunjukan dengan hasil wawancara dan observasi yang dilakukan sebelum penelitian ini dilakukan dimana keaktifan belajar siswa secara individu 14% dan keaktifan belajar siswa secara kelompok 50% dan hasil belajar matematika siswa pada materi sebelumnya juga menunjukkan hasil belajar yang rendah dimana dari 32 siswa 6.25% siswa mendapatkan nilai tuntas dengan rata-rata 34,3. Setelah dilakukan tindakan pada siklus I, terjadi peningkatan terhadap keaktifan belajar dan hasil belajar matematika. Lembar observasi pada siklus I menunjukkan keaktifan siswa secara individu meningkat menjadi 27.4% dan keaktifan belajar siswa secara kelompok 65% dan

MENINGKATKAN AKTIVITAS BELAJAR SISWA DENGAN MENGGUNAKAN METODE GROUP INVESTIGATION (GI PADA POKOK BAHASAN PASAR DI KELAS VIII SMP 5 KUDUS

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Mutthofiyah Mutthofiyah

2016-03-01

Full Text Available Penelitian ini bertujuan untukmeningkatkan aktivitas belajar siswa dengan menggunakan metode group investigation (GI pada pokok bahasan pasar pada penelitian ini menggunakan penelitian tindakan kelas (PTK. Dalam penelitian ini dirancang menggunakan siklus, masing-masing siklus dengan tahapan perencanaan, pelaksanaan tindakan, observasi dan refleksi. Teknik pengumpulan data pada penelitian ini adalah dokumentasi, observasi dan tes.Hasil penelitian menunjukkan melalui meningkatkan metode group investigation (GI aktivitas siswa SMP 5 Kudus ada peningkatan yang sigifikan, dari siklus I kelas VIII F 15,8 (41,62% meningkat di siklus II menjadi 24,8 (72,9%, sedangkan di kelas VIII G siklus I 18,5 (47,04% meningkat menjadi 26,2 (74,7%; melalui penerapan metode group investigation hasil belajar siswa SMP 5 kudus meningkat sangat signifkan, ketuntasan belajar secara klasikal dari kelas VIII F pra siklus sebesar 17,64% terjadi peningkatan 47% ke siklus I dan meningkat menjadi 82,35% di siklus II. Sedangkan di kelas VII G pra siklus sebesar 22,85% meningkat 54,28% di siklus I dan meningkat menjadi 94,28% di siklus II. Saran yang peneliti berikan adalah sebagai berikut:1Kepada para guru diharapkan dapat menerapkan pembelajaran kooperatif khususnya pembelajaran kooperatif tipe Group Investigation (GI dalam proses pembelajaran ekonomi dan mata pelajaran lainya dan mengembangkannya; 2 Kepada para peneliti selanjutnya diharapkan dapat melakukan penelitian tentang penerapan model pembelajaran yang dapat membangkitkan keaktifan siswa untuk belajar ekonomi. This study aims to improve students' learning activities using group investigation (GI on the subject of markets in class VIII SMP 5 Kudus. In this study is designed to use cycles, with each cycle stages of planning, action, observation and reflection. Data collection techniques in this study is documentation, observation and tests. Results showed through improved methods of group investigation (GI junior 5 high

Kemampuan Representasi Matematis Menurut Tingkat Kemampuan Siswa pada Materi Segi Empat di SMP

OpenAIRE

Aryanti, Devi; -, Zubaidah; Nursangaji, Asep

2013-01-01

The purpose of this research is to know the ability and tendency of mathematical representation in solve the word problem about quadrilateral matter at SMP 03 Semparuk. The method of this research is descriptive research survey. The subject of this research is the VIIIC class at SMPN 03 Semparuk. The result analysis data show that the high level student have high enactive representation capability, low iconic representation and very high symbolic representations ability. The intermediate leve...

PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE STAD BERBANTUAN PEMETAAN PIKIRAN (MIND MAPPING TERHADAP KEMAMPUAN MENULIS TEKS BERITA SISWA KELAS VIII SMP NEGERI 1 PANTI

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Ricci Gemarni Tatalia, M.Pd

2017-05-01

Full Text Available This study was generated from the problem of students’ ability in writing news texts ini class VIII, SMPN 1 Panti. Some of the problem were (1 lack of the students’ response towards news writing teaching and learning process, (2 lack of teacher’s creativity in designing interesting news sriting learning model, (3 no appropriate creative techniques applied by the teacher which could train the students to develop their skill in writing news texts and (4 lack of the students’ motivation in participating in teaching and learning process because of their lack of understanding in the elements of news. Thus, this study was aimed at escribing the effect of the students’ ability ini writing news texts in class VIII SMP N 1 Panti. This was a quantitative research with factorial 2x2 experimental design. The population was the students in class VIII SMPN 1 Panti. Sampling technique was done by using random sampling and the data was collected through test. The result of the study revealed that cooperative learning model with STAD mind mapping type affected the students’ ability in writing news texts

Kemampuan Representasi Matematis Siswa SMP Melalui Pendekatan Pendidikan Matematika Realistik

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Sulastri Sulastri

2017-06-01

Full Text Available [Bahasa]: Penelitian kualitatif ini bertujuan untuk mendeskripsikan kemampuan representasi matematis siswa melalui pendekatan Pendidikan Matematika Realistik (PMR. Penelitian ini dilakukan di kelas VII-2 SMP Negeri 6 Banda Aceh yang melibatkan enam siswa.  Kemampuan representasi siswa dianalisis dari hasil tes dan wawancara setelah penerapan PMR melalui tahap reduksi data, penyajian data, dan penarikan kesimpulan. Berdasarkan hasil tes, subjek penelitian dikategorikan menjadi siswa dengan kemampuan representasi matematika tinggi, sedang dan rendah. Keenam siswa tersebut diwawancara untuk mengonfirmasi hasil tes. Hasil penelitian menunjukan bahwa siswa yang berkemampuan tinggi dan sedang memenuhi ketiga indikator kemampuan representasi matematis yaitu menyajikan data atau informasi dari suatu masalah ke representasi tabel, menyelesaikan masalah yang melibatkan ekspresi matematis, serta menuliskan langkah-langkah penyelesaian masalah matematika dengan kata-kata. Siswa berkemampuan rendah memenuhi dua indikator kemampuan representasi matematis yaitu menyelesaikan masalah yang melibatkan ekspresi matematis dan menuliskan langkah-langkah penyelesaian masalah matematika dengan kata-kata. Kata kunci:   Representasi Matematis; Kemampuan; Pendidikan Matematika Realistik [English]: This qualitative reseach aims at describing students’ representation ability through realistic mathematics education (RME. It is conducted in grade VII-2 SMP Negeri 6 Banda Aceh focusing on the six students. Students’ representation ability is analyzed from the developed test and interview after applying RME through data reduction, data display and conclusion. Based on the result of the test, the subjects are categorized into students who have high, medium and low ability in mathematical representation. They are then interviewed to confirm the test. The research finds that students in high and medium category fulfill the three indicators of mathematical representation, i

PENGEMBANGAN MODEL KOOPERATIF MODELING THE WAY DENGAN TEKNIK RENDRA DALAM PEMBELAJARAN BERMAIN DRAMA BERMUATAN PENDIDIKAN KARAKTER PADA PESERTA DIDIK SMP KELAS VIII

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Andhi Nugeraha Setiaji

2014-08-01

Full Text Available Pembelajaran drama di SMP masih berlangsung kurang maksimal. Model pembelajaran drama yang digunakan juga masih sangat terbatas. Salah satu alternatif model pembelajaran yang bisa digunakan adalah model kooperatif Modeling the Way. Rumusan masalah penelitian ini adalah bagaimana: kebutuhan pengembangan, prinsip pengembangan, prototipe, dan keefektifan model Modeling the Way . Tujuan penelitian ini adalah mengidentifikasi kebutuhan pengembangan, merumuskan prinsip pengembangan, mengembangkan prototipe, dan mengidentifikasi keefektifan model Modeling the Way. Penelitian ini dilakukan dengan desain penelitian R&D. Langkah penelitian ini adalah studi literatur, analisis kebutuhan pengembangan, pengembangan model, uji validasi, revisi, penerapan, revisi, pengembangan model akhir. Teknik pengumpulan data dilaksanakan melalui angket, jurnal, lembar pengamatan, lembar uji validasi, dan teknik tes. Instrumen yang digunakan adalah angket analisis kebutuhan pengembangan, lembar uji validasi, observasi, motivasi,  dan kreativitas peserta didik, serta lembar tes. Teknik analisis data yang digunakan adalah teknik analisis data kebutuhan, uji validasi ahli, dan teknik analisis data uji coba terbatas Hasil penelitian ini adalah sebagai berikut. Kebutuhan pengembangan model Modeling the Way adalah diskusi, guru mengaitkan materi sebelumnya dengan materi yang  dipelajari, dan peserta didik memberikan evaluasi terhadap temannya. Prinsi model ini adalah kerja sama,  kreativitas individu, dan naskah drama bermuatan pendidikan karakter. During this learning in junior high drama still going on less than the maximum. Learners must find their own practice and role-play techniques. Examples of dramatic play techniques demonstrated by the teacher is still less than the maximum . In fact, sometimes the teacher does not show an example of dramatic play. Learning model used drama is still very limited. Often learners immediately given the task to find, read, and

Theoretical model for calculation of molecular stopping power

International Nuclear Information System (INIS)

Xu, Y.J.

1984-01-01

A modified local plasma model based on the work of Linhard-Winther, Bethe, Brown, and Walske is established. The Gordon-Kim's molecular charged density model is employed to obtain a formula to evaluate the stopping power of many useful molecular systems. The stopping power of H 2 and He gas was calculated for incident proton energy ranging from 100 KeV to 2.5 MeV. The stopping power of O 2 , N 2 , and water vapor was also calculated for incident proton energy ranging from 40 keV to 2.5 MeV. Good agreement with experimental data was obtained. A discussion of molecular effects leading to departure from Bragg's rule is presented. The equipartition rule and the effect of nuclear momentum recoiling in stopping power are also discussed in the appendix. The calculation procedure presented hopefully can easily be extended to include the most useful organic systems such as the molecules composed of carbon, nitrogen, hydrogen and oxygen which are useful in radiation protection field

EFEKTIVITAS PERAN KOPERASI SEKOLAH SEBAGAI UNIT PEMBELAJARAN KEWIRAUSAHAAN DI SMP NEGERI 1 KARANGANYAR KABUPATEN PEKALONGAN

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Dea Prilia Sari

2013-02-01

Full Text Available Di SMP Negeri 1 Karanganyar Kabupaten Pekalongan, koperasi sekolah menyediakan jasa penjualan berbagai keperluan para siswa. Penelitian ini bertujuan mengetahui efektivitas peran koperasi sekolah sebagai unit pembelajaran kewirausahaan. Tipe penelitian yaitu kualitatif dengan proses analisis deskriptif evaluatif. Berdasarkan hasil analisis koperasi sekolah terbukti efektif sebagai pembelajaran kewirausahaan siswa tetapi masih mempunyai beberapa kendala. Kendala-Kendala yang dihadapi yaitu �waktu yang terbatas, tempat yang sempit dan modal juga sangat terbatas serta sifat personality yang beragam. Strategi yang digunakan yaitu membentuk tim guru pembina yang bertanggung jawab atas keberadan koperasi. � Abstract ___________________________________________________________________ In SMP Negeri 1 Karanganyar Pekalongan, cooperative schools provide students selling various purposes. this study aims to determine the effectiveness of� cooperative learning school as the unit of entrepreneurship. This type of research used is descriptive qualitative analysis process evaluative. Based on the analysis of school cooperatives proved to be effective as a learning entrepreneurship students but still have some problems. constraints faced by the limited time, the place is also very narrow and limited capital as well as diverse personality trait. the strategy used is to set up a teacher coach is responsible for the existence of cooperative

An Analysis on Students' Speaking Skill at Second Grade SMP 8 Rambah Hilir

OpenAIRE

Harahap, Siti Surinah; Antoni, Rivi; Rasyidah, Ummi

2015-01-01

The purpose of this research was to find out students speaking skill. Speaking is one of the some skills among listening, writing, reading.This research used descriptive qualitative research design.where the writer described and analyzed the students' errors in speaking skill. The population of this research was taken from the second grade students' at Smp 8 Rambah Hilir in Rambah Hilir district is about 21 students.Based on the result, the writer concludes that the second grade students' of ...

Hubungan Kecerdasan Emosional dan Kemampuan Menyelesaikan Masalah Matematika Siswa di SMP Bumi Khatulistiwa

OpenAIRE

Rospitasari, Murni

2017-01-01

This reseach aimed to know the correlation among emotional intelligence and the ability of mathematics problem solving of the ninth grade students of SMP Bumi Khatulistiwa Sungai Raya. The method that used un this reseach was a quatitative descriptive with Ex Post Facto form. The subject of this research were the ninth grade students class B that consist of 13 student. Data collection techniques in this research was a measurement technique in the form of essay and the scale of emotional inte...

DENSE CLUMPS AND CANDIDATES FOR MOLECULAR OUTFLOWS IN W40

Energy Technology Data Exchange (ETDEWEB)

Shimoikura, Tomomi; Dobashi, Kazuhito [Department of Astronomy and Earth Sciences, Tokyo Gakugei University, Koganei, Tokyo 184-8501 (Japan); Nakamura, Fumitaka; Hara, Chihomi; Kawabe, Ryohei [National Astronomical Observatory of Japan, Mitaka, Tokyo 181-8588 (Japan); Tanaka, Tomohiro [Department of Physical Science, Osaka Prefecture University, Sakai, Osaka 599-8531 (Japan); Shimajiri, Yoshito [Laboratoire AIM, CEA/DSM-CNRS-Université Paris Diderot, IRFU/Service d’Astrophysique, CEA Saclay, F-91191 Gif-sur-Yvette (France); Sugitani, Kouji, E-mail: ikura@u-gakugei.ac.jp [Graduate School of Natural Sciences, Nagoya City University, Mizuho-ku, Nagoya 467-8501 (Japan)

2015-06-20

We report the results of the {sup 12}CO (J = 3−2) and HCO{sup +} (J = 4−3) observations of the W40 H ii region with the Atacama Submillimeter Telescope Experiment (ASTE) 10 m telescope (HPBW ≃ 22″) to search for molecular outflows and dense clumps. We found that the velocity field in the region is highly complex, consisting of at least four distinct velocity components at V{sub LSR} ≃ 3, 5, 7, and 10 km s{sup −1}. The ∼7 km s{sup −1} component represents the systemic velocity of cold gas surrounding the entire region, and causes heavy absorption in the {sup 12}CO spectra over the velocity range 6 ≲ V{sub LSR} ≲ 9 km s{sup −1}. The ∼5 and ∼10 km s{sup −1} components exhibit high {sup 12}CO temperature (≳40 K) and are found mostly around the H ii region, suggesting that these components are likely to be tracing dense gas interacting with the expanding shell around the H ii region. Based on the {sup 12}CO data, we identified 13 regions of high velocity gas, which we interpret as candidate outflow lobes. Using the HCO{sup +} data, we also identified six clumps and estimated their physical parameters. On the basis of the ASTE data and near-infrared images from 2MASS, we present an updated three-dimensional model of this region. In order to investigate molecular outflows in W40, the SiO (J = 1−0, v = 0) emission line and some other emission lines at 40 GHz were also observed with the 45 m telescope at the Nobeyama Radio Observatory, but they were not detected at the present sensitivity.

Changes in Enteric Neurons of Small Intestine in a Rat Model of Irritable Bowel Syndrome with Diarrhea.

Science.gov (United States)

Li, Shan; Fei, Guijun; Fang, Xiucai; Yang, Xilin; Sun, Xiaohong; Qian, Jiaming; Wood, Jackie D; Ke, Meiyun

2016-04-30

Physical and/or emotional stresses are important factors in the exacerbation of symptoms in irritable bowel syndrome (IBS). Several lines of evidence support that a major impact of stress on the gastrointestinal tract occurs via the enteric nervous system. We aimed to evaluate histological changes in the submucosal plexus (SMP) and myenteric plexus (MP) of the distal ileum in concert with the intestinal motor function in a rat model of IBS with diarrhea. The rat model was induced by heterotypic chronic and acute stress (CAS). The intestinal transit was measured by administering powdered carbon by gastric gavage. Double immunohistochemical fluorescence staining with whole-mount preparations of SMP and MP of enteric nervous system was used to assess changes in expression of choline acetyltransferase, vasoactive intestinal peptide, or nitric oxide synthase in relation to the pan neuronal marker, anti-Hu. The intestinal transit ratio increased significantly from control values of 50.8% to 60.6% in the CAS group. The numbers of enteric ganglia and neurons in the SMP were increased in the CAS group. The proportions of choline acetyltransferase- and vasoactive intestinal peptide-immunoreactive neurons in the SMP were increased (82.1 ± 4.3% vs. 76.0 ± 5.0%, P = 0.021; 40.5 ± 5.9% vs 28.9 ± 3.7%, P = 0.001), while nitric oxide synthase-immunoreactive neurons in the MP were decreased compared with controls (23.3 ± 4.5% vs 32.4 ± 4.5%, P = 0.002). These morphological changes in enteric neurons to CAS might contribute to the dysfunction in motility and secretion in IBS with diarrhea.

PENINGKATAN SOFT SKILLS SISWA SMP MELALUI PEMBELAJARAN GENERATIF

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La Moma

2015-06-01

Full Text Available Abstrak: Soft skills merupakan faktor yang turut menunjang kesuksesan siswa belajar matematika. Perlu ada upaya untuk menerapkan suatu model pembelajaran yang dapat memicu peningkatan soft skills siswa dalam matematika. Penelitian ini menerapkan model pembelajaran generatif sebagai alternatif pembelajaran yang diperkirakan akan memicu peningkatan ketiga kemampuan tersebut. Tujuan penelitian untuk mengetahui seberapa besar kontribusi penerapan model tersebut terhadap peningkatan kemampuan soft skills pada level sekolah (tinggi, sedang dan rendah. Penelitian menerapkan desain kuasi eksperimen. Sampel terdiri atas 191 orang siswa kelas VIII pada tiga SMP Negeri di Kota Yogyakarta yang mewakili level sekolah. Pengumpulan data dilakukan dengan teknik tes (pretes dan postes, sedang analisis data menggunakan statistik uji-t dan anova dua jalur. Dari hasil analisis data ditemukan bahwa (1 ada perbedaan pencapaian, peningkatan soft skills siswa antara kelas eksperimen dan kelas kontrol; (2 tidak terdapat interaksi antara pembelajaran dan level sekolah terhadap peningkatan soft skills. Kata Kunci: kemampuan soft skills, pembelajaran generatif THE ENHANCEMENT OF JUNIOR HIGH SCHOOL STUDENTS SOFT SKILLS THROUGH GENERATIVE LEARNING Abstract: Soft skills are factors that support students success in learning mathematics. The importance of the students soft skills, unfortunately, are not in line with at the students abilities in these competence. Therefore, we have to implemented a learning model that is expected to lead development soft skills of the students in mathematics. Generative learning model is applied in this study as an alternative learning is predicted to stimulate development soft skills of the students. This study is aimed at determining the contribution of generative learning model of the enhancement of soft skills for difference school levels (high, medium, low.This study is quasi-experimental research involving 191 students of eight

PENERAPAN METODE MIND MAPPING (PETA PIKIRAN UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KREATIF MATEMATIK SISWA SMP

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Rijal Darusman

2014-09-01

Full Text Available ABSTRAK Masalah yang melatar belakangi penelitian ini adalah masih rendahnya kemampuan berpikir kreatif matematik siswa Sekolah Menengah Pertama (SMP, sehingga diperlukan metode pembelajaran untuk mengatasi masalah tersebut. Metode yang diterapkan adalah Metode Mind Mapping, dikarenakan dengan metode pembelajaran mind mapping kemampuan berpikir kreatif matematik siswa  lebih baik jika dibandingkan dengan metode pembelajaran biasa.Berdasarkan latar belakang tersebut maka penelitian ini bertujuan untuk mengetahui apakah kemampuan berpikir kreatif matematik siswa yang pembelajarannya menggunakan metode mind mapping lebih baik daripada siswa yang pembelajarannya biasa. Penelitian ini merupakan kuasi eksperimen berbentuk kelompok kontrol pretes-postes, dengan perlakuan metode pembelajaran mind mapping dan pembelajaran biasa (konvensional. Pengumpulan data dalam penelitian ini berupa tes uraian sebanyak 4 soal, kemudian data skor kemampuan berpikir kreatif matematik siswa tersebut dianalisis dengan statistik deskriptif dan inferensial dengan menggunakan uji perbedaan dua rata-rata. Berdasarkan hasil analisis data diperoleh kesimpulan bahwa peningkatan kemampuan berpikir kreatif matematik siswa SMP yang pembelajarannya menggunakan metode mind mapping lebih baik daripada cara biasa.  Kata Kunci    : Berpikir Kreatif Matematik, Mind Mapping   ABSTRACT The problem of the background of this research is still low ability to think creatively mathematical school students (SMP, so that the necessary learning methods to overcome these problems. The method applied is Mind Mapping method, because the mind mapping method of learning mathematics students' creative thinking ability is better when compared to the learning method biasa.Berdasarkan this background, this study aims to determine whether the ability of creative thinking of students learning mathematics using mind mapping better than the usual student learning. This research is a form of quasi

EKSPERIMENTASI MODEL PEMBELAJARAN KOOPERATIF TIPE THINK PAIR SHARE (TPS DITINJAU DARI KEMANDIRIAN BELAJAR SISWA KELAS VIII SMP NEGERI DI KOTA YOGYAKARTA

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Annis Deshinta Ayuningtyas

2015-02-01

Full Text Available Tujuan penelitian ini yaitu untuk mengetahui: (1 manakah yang memberikan prestasi belajar lebih baik diantara model pembelajaran kooperatif tipe TPSatau pembelajaran langsung, (2 manakah yang mempunyai prestasi belajar lebih baik di antara siswa yang mempunyai kemandirian belajar tinggi, sedang, atau rendah, (3 pada masing-masing tingkatan kemandirian belajar (tinggi, sedang, dan rendah, manakah yang memberikan prestasi belajar lebih baik antara model pembelajaran kooperatif tipe TPS atau pembelajaran langsung. Penelitian ini termasuk penelitian eksperimental semu dengan desain factorial 2x3. Populasi dalam penelitian ini adalah seluruh siswa kelas VIII Sekolah Menengah Pertama (SMP Negeri Se-Kota Yogyakarta Semester I tahun pelajaran 2011/2012. Teknik pengambilan sampel dilakukan dengan carastratified cluster random sampling. Banyak sampel adalah 195 siswa. Instrumen yang digunakan untuk mengumpulkan data adalah angket kemandirian belajar siswa dan tes prestasi belajar matematika. Uji coba angket meliputi validitas isi, konsistensi internal dan reliabilitas. Uji coba tes prestasi meliputi validitas isi, tingkat kesukaran, daya beda dan reliabilitas. Untuk uji normalitas menggunakan uji Lilliefors, uji homogenitas menggunakan uji barlett. Uji keseimbangan yang digunakan yaitu anava satu jalan dengan sel tak sama. Analisis tes prestasi matematika menggunakan analisis variansi dua jalan dengan sel tak sama. Dari hasil analisis diperoleh kesimpulan bahwa: (1 Prestasi belajar matematika dengan model pembelajaran kooperatiftipe TPS memberikan prestasi belajar yang lebih baik daripada model pembelajaran langsung, (2 Siswa yang kemandirian belajarnya tinggi mempunyai prestasi belajar yang lebih baik daripada siswa dengan kemandirian belajar sedang dan rendah, sedangkan siswa yang kemandirian belajarnya sedang mempunyai prestasi belajar yang sama dengan siswa dengan kemandirian belajar rendah, (3 Pada siswa yang mempunyai kemandirian belajar tinggi

PENINGKATAN AKTIVITAS DAN HASIL BELAJAR POKOK BAHASAN PASAR DENGAN METODE RESITASI PADA SISWA KELAS VIII SMP NEGERI 24 SEMARANG TAHUN AJARAN 2013/2014

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Diinul Qoyyimah

2013-11-01

Full Text Available Aktivitas siswa kelas VIII pada mata pelajaran ekonomi SMP Negeri 24 Semarang pada pokok bahasan pasar masih rendah sehingga berdampak pada hasil belajar siswa yang masih dibawah KKM. Salah satu penyebabnya karena guru masih menerapkan metode belajar yang sama dalam waktu yang lama sehingga mengakibatkan rendahnya perolehan hasil belajar. Melalui penerapan metode ceramah bervariasi dan resitasi diharapkan siswa dapat belajar dengan santai dan senang dalam mengikuti proses pembelajaran. Penelitian ini bertujuan untuk mengetahui penerapan metode resitasi, dapat meningkatkan aktivitas dan hasil belajar siswa. Metode penelitian menggunakan penelitian tindakan kelas. Prosedur penelitian dilakukan dimulai dengan perencanaan, pelaksanaan, observasi dan refleksi. Metode pengumpulan data dengan dokumentasi dan tes. Hasil penelitian menyatakan bahwa ada peningkatan aktivitas siswa dan hasil belajar siswa materi pasar pada kelas VIII SMP Negeri 24 Semarang tahun 2013/2014. The students’ activity in VIII class of economic subject in SMP Negeri 24 Semarang in the subject matter of market topic is still low so it has the impact on the students’ learning outcome which is still under KKM requirements. One of the causes is because the teachers are still apply the same learning method in a long time so it resulted in low learning outcomes acquisition.through the application of various conventional methods and recitation are expected that students can learn easily and pleasure in participating of learning process. This study aims to determine the application of recitation method which can improve the activity and students’ learning outcomes. The research method using classroom action research. The research procedure begins with planning, implementation, observation and reflection. Methods of data collection carried out by documentation and test. The result of research states that there is an increasing activity and students’ learning outcomes in the

Autoestima y motivación en el rendimiento académico de los estudiantes de la I.E “Rodríguez Trigoso” SMP- 2015

OpenAIRE

Fonseca Rosales, Ruth Elizabeth

2017-01-01

La investigación titulada Autoestima y motivación en el rendimiento académico en los estudiantes del segundo grado de secundaria la I.E “Rodríguez Trigoso” SMP- 2015”, tiene como problema general ¿Cuál es la influencia de la autoestima y la motivación en el rendimiento académico de los estudiantes del segundo grado de secundaria la I.E “Rodríguez Trigoso” SMP-2015? La metodología empleada fue de un tipo básica-descriptivo- correlacional causal; un diseño no experimental tran...

Gradient models in molecular biophysics: progress, challenges, opportunities

Science.gov (United States)

Bardhan, Jaydeep P.

2013-12-01

In the interest of developing a bridge between researchers modeling materials and those modeling biological molecules, we survey recent progress in developing nonlocal-dielectric continuum models for studying the behavior of proteins and nucleic acids. As in other areas of science, continuum models are essential tools when atomistic simulations (e.g., molecular dynamics) are too expensive. Because biological molecules are essentially all nanoscale systems, the standard continuum model, involving local dielectric response, has basically always been dubious at best. The advanced continuum theories discussed here aim to remedy these shortcomings by adding nonlocal dielectric response. We begin by describing the central role of electrostatic interactions in biology at the molecular scale, and motivate the development of computationally tractable continuum models using applications in science and engineering. For context, we highlight some of the most important challenges that remain, and survey the diverse theoretical formalisms for their treatment, highlighting the rigorous statistical mechanics that support the use and improvement of continuum models. We then address the development and implementation of nonlocal dielectric models, an approach pioneered by Dogonadze, Kornyshev, and their collaborators almost 40 years ago. The simplest of these models is just a scalar form of gradient elasticity, and here we use ideas from gradient-based modeling to extend the electrostatic model to include additional length scales. The review concludes with a discussion of open questions for model development, highlighting the many opportunities for the materials community to leverage its physical, mathematical, and computational expertise to help solve one of the most challenging questions in molecular biology and biophysics.

MENINGKATKAN PRESTASI BELAJAR SEJARAH SISWA SMP NEGERI 1 LIMPUNG MELALUI PEMANFAATAN SITUS BATANG KUNO

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Butuk Buwang

2011-10-01

Full Text Available Batang regency has many historical sites, especially the classical heritage of Indonesia. Sites located at County Trunk can be used as an alternative source of learning for students of history. The purpose of this research is to find out how to improve school performance through the use of historical sites in the study of ancient trunk. This study uses classroom action research. Research carried out in SMP N 1 Limpung. The results showed that the use of stem sites through field trip activities can enhance learning achievement of history. This is prooven with an increase in each cycle until it reaches the complete study in cycle II.   Key words: learning achievement, history, sites of ancient Batang   Kabupaten Batang memiliki banyak situs sejarah, khususnya warisan klasik Indonesia. Situs yang terletak di Kabupaten Batang dapat digunakan sebagai alternatif sumber belajar bagi siswa sejarah. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana memperbaiki kinerja sekolah melalui penggunaan situs sejarah dalam studi batang kuno. Penelitian ini menggunakan penelitian tindakan kelas. Penelitian yang dilakukan di SMP N 1 Limpung. Hasil penelitian menunjukkan bahwa penggunaan situs induk melalui kegiatan field trip dapat meningkatkan prestasi belajar sejarah. Hal ini dibuktikan dengan peningkatan pada setiap siklus sampai mencapai ketuntasan belajar pada siklus II.   Kata kunci: prestasi belajar, sejarah, situs Batang kuno  

PENGARUH PENGGUNAAN METODE PEMBELAJARAN DAN GAYA KOGNITIF TERHADAP HASIL BELAJAR MATEMATIKA SISWA SMP

OpenAIRE

Martinawati, Martinawati; kamid, Kamid; Asyhar, Rayandra

2015-01-01

This study aims to determine the effect of the method of learning and cognitive style on learning outcomes of junior high school math students. Research conducted at SMP Negeri 6 Tungkal Ulu, in classVII, the second semester in the Academic Year 2012/2013. The research design uses 3x2 factorial design. One treatment/factor with three levels (X1, X2 and X3) and the moderator variable that has two levels (Y1 and Y2). Research instrument stome asure the independent variable is the design of lear...

Kemampuan Representasi Matematis Siswa pada Materi Segi Empat di Kelas VIII SMP Kemala Bhayangkari

OpenAIRE

Nelli,; Yusmin, Edy; Sayu, Silvia

2015-01-01

The purpose of this research is to reveal the students ability of representation enactive, iconic, and symbolic on the quadrilateral matter in the class 8 SMP Kemala Bhayangkari. The method that is used is descriptive research in survey research mode. Based on the result of research, student's enactive representation aspects identified that student is able to put a square on the frame and students at the intermediate and lower ability is not able to fold a square of paper according the line, ...

Molecular Modeling

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 9; Issue 5. Molecular Modeling: A Powerful Tool for Drug Design and Molecular Docking. Rama Rao Nadendla. General Article Volume 9 Issue 5 May 2004 pp 51-60. Fulltext. Click here to view fulltext PDF. Permanent link:

A Novel Analytical Model for Network-on-Chip using Semi-Markov Process

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WANG, J.

2011-02-01

Full Text Available Network-on-Chip (NoC communication architecture is proposed to resolve the bottleneck of Multi-processor communication in a single chip. In this paper, a performance analytical model using Semi-Markov Process (SMP is presented to obtain the NoC performance. More precisely, given the related parameters, SMP is used to describe the behavior of each channel and the header flit routing time on each channel can be calculated by analyzing the SMP. Then, the average packet latency in NoC can be calculated. The accuracy of our model is illustrated through simulation. Indeed, the experimental results show that the proposed model can be used to obtain NoC performance and it performs better than the state-of-art models. Therefore, our model can be used as a useful tool to guide the NoC design process.

Problem Solving Model for Science Learning

Science.gov (United States)

Alberida, H.; Lufri; Festiyed; Barlian, E.

2018-04-01

This research aims to develop problem solving model for science learning in junior high school. The learning model was developed using the ADDIE model. An analysis phase includes curriculum analysis, analysis of students of SMP Kota Padang, analysis of SMP science teachers, learning analysis, as well as the literature review. The design phase includes product planning a science-learning problem-solving model, which consists of syntax, reaction principle, social system, support system, instructional impact and support. Implementation of problem-solving model in science learning to improve students' science process skills. The development stage consists of three steps: a) designing a prototype, b) performing a formative evaluation and c) a prototype revision. Implementation stage is done through a limited trial. A limited trial was conducted on 24 and 26 August 2015 in Class VII 2 SMPN 12 Padang. The evaluation phase was conducted in the form of experiments at SMPN 1 Padang, SMPN 12 Padang and SMP National Padang. Based on the development research done, the syntax model problem solving for science learning at junior high school consists of the introduction, observation, initial problems, data collection, data organization, data analysis/generalization, and communicating.

Characteristics and fates of soluble microbial products in ceramic membrane bioreactor at various sludge retention times.

Science.gov (United States)

Shin, Hang-Sik; Kang, Seok-Tae

2003-01-01

The formation and fate of soluble microbial products (SMP) in membrane bioreactor (MBR) was investigated at various sludge retention times (SRT) for 170 days. The SMP concentration was estimated by feeding glucose, which could be completely degraded, and by measuring the dissolved organic carbon (DOC) of the effluent from MBR. Under the conditions of SRT of 20 days, influent DOC of 112 mg/l and HRT of 6 h, the produced SMP was 4.7 mg DOC/l of which 57% was removed or retained by the membrane. DOC of MBR supernatant increased during 100 days and then gradually decreased. Specific UV absorbance showed that the accumulated compounds had a portion of larger, more aromatic, more hydrophobic and double-bond-rich organics, which originated from the decayed biomass. Molecular weight distributions of SMP in MBR supernatant showed that the acclimated microorganisms in a long SRT could decompose high molecular weight organics, it caused the shift of molecular weight distributions of SMP to a lower range. During the operation period, enumeration of active cells in the MBR showed that microbial inhibitions by accumulated SMP was not observed.

Influence of solids retention time on membrane fouling: characterization of extracellular polymeric substances and soluble microbial products.

Science.gov (United States)

Duan, Liang; Tian, Zhiyong; Song, Yonghui; Jiang, Wei; Tian, Yuan; Li, Shan

2015-01-01

The objective of this study was to investigate the influence of solids retention time (SRT) on membrane fouling and the characteristics of biomacromolecules. Four identical laboratory-scale membrane bioreactors (MBRs) were operated with SRTs for 10, 20, 40 and 80 days. The results indicated that membrane fouling occurred faster and more readily under short SRTs. Fouling resistance was the primary source of filtration resistance. The modified fouling index (MFI) results suggested that the more ready fouling at short SRTs could be attributed to higher concentrations of soluble microbial products (SMP). Fourier transform infrared (FTIR) spectra indicated that the SRT had a weak influence on the functional groups of the total extracellular polymeric substances (TEPS) and SMP. However, the MBR under a short SRT had more low-molecular-weight (MW) compounds (100 kDa). Aromatic protein and tryptophan protein-like substances were the dominant groups in the TEPS and SMP, respectively.

Hubungan Kecemasan Sosial dan Kematangan Emosi dengan Kematangan Seksual Remaja SMP di Kabupaten Bantul Yogyakarta

OpenAIRE

Endang Sri Lestari

2012-01-01

This research aims to find out some factors related to the sexual maturity, such as the social anxiety and emotional maturity on the adolescents of the SMP in Kabupaten Bantul, Yogyakarta. The hypotheses which are presented in this research are: First; there is a relation between the social anxiety and emotional maturity towards the sexual maturity; Second, there is a negative relation between the social anxiety and sexual maturity; Third, there is a positive relation between the emotional ma...

Assessment of Molecular Modeling & Simulation

Energy Technology Data Exchange (ETDEWEB)

None

2002-01-03

This report reviews the development and applications of molecular and materials modeling in Europe and Japan in comparison to those in the United States. Topics covered include computational quantum chemistry, molecular simulations by molecular dynamics and Monte Carlo methods, mesoscale modeling of material domains, molecular-structure/macroscale property correlations like QSARs and QSPRs, and related information technologies like informatics and special-purpose molecular-modeling computers. The panel's findings include the following: The United States leads this field in many scientific areas. However, Canada has particular strengths in DFT methods and homogeneous catalysis; Europe in heterogeneous catalysis, mesoscale, and materials modeling; and Japan in materials modeling and special-purpose computing. Major government-industry initiatives are underway in Europe and Japan, notably in multi-scale materials modeling and in development of chemistry-capable ab-initio molecular dynamics codes.

GAMBARAN TINGKAT DEPRESI TERHADAP PERILAKU BULLYING PADA SISWA DI SMP PGRI 2 DENPASAR

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I Gede Surya Kardiana

2015-06-01

Full Text Available Remaja merupakan individu yang sedang dalam tahapan perkembangan transisi, sehingga pada tahapan ini banyak permasalahan yang sering muncul seperti perilaku bullying. Bullying merupakan tindakan agresif yang terus menerus dapat berupa bentuk fisik, verbal, dan psikologis. Perilaku bullying ini dapat menyebabkan gangguan fisik maupun psikologis salah satunya dapat mengalami depresi. Depresi ini dapat mempengaruhi aktivitas belajarnya sehingga perlu dideteksi secara dini tentang gambaran tingkat depresi terhadap perilaku bullying di SMP PGRI 2 Denpasar. Penelitian ini merupakan penelitian deskirptif kuantitatif dengan rancangan deskiptif cross sectional yang dilakukan pada tanggal 22 Maret 2015 di SMP PGRI 2 Denpasar. Sampel diambil dengan teknik stratified random sampling dan didapatkan 95 sampel yang memenuhi kriteria inklusi dan ekslusi. Data dikumpulkan dengan menggunakan kuisioner victimization scale - adolenscent peer relations instrument dan Beck depression inventory (BDI. Hasil Penelitian ditemukan sebesar 28,4% mengalami perilaku bullying intensitas ringan dan 6,3% mengalami perilaku bullying intensitas sedang dan responden lainnya tidak pernah mengalami perilaku bullying. Tingkat depresi ditemukan 26,3% depresi ringan, 14,7% depresi sedang dan responden lainnya normal. Kecenderungan siswa yang mengalami perilaku bullying intensitas sedang mengalami depresi sedang sebesar 66,7%, dan dari yang mengalami perilaku bullying intensitas ringan sebesar 33,3% mengalami depresi ringan. Siswa yang mengalami perilaku bullying intensitas sedang cenderung mengalami depresi sedang. Perilaku bullying yang paling sering dilakukan yaitu bullying verbal, diikuti bullying fisik. Perempuan cenderung menjadi korban bullying daripada laki-laki. Kesimpulan, perlu penelitian lebih lanjut untuk faktor-faktor lainnya yang dapat mempengaruhi perilaku bullying dan tingkat depresi pada siswa.

EFEKTIVITAS PENGGUNAAN LINGKUNGAN SEBAGAI SUMBER BELAJAR MATERI IPA POKOK BAHASAN EKOSISTEM PADA KELAS VII SMP N 2 PRINGAPUS KABUPATEN SEMARANG TERHADAP HASIL BELAJAR SISWA

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miftakhul jannah

2016-02-01

Penelitian ini bertujuan untuk mengetahui efektivitas pembelajaran IPA khususnya kelas VII   menggunakan lingkungan langsung   sebagai sumber belajar  terhadap hasil belajar siswa kelas VII  SMP N 2 Pringapus Kabupaten Semarang  pada poko bahasan  materi  ekosistem. Hasil pene- litian ini  merupakan penelitian kuantitatif dengan metode penelitian eks- perimen terpola bentuk posttest control design. Populasi dalam penelitian ini adalah peserta didik kelas VII SMP N 2 Pringapus Semarang, yaitu kelas VII A sebagai kelas eksperimen dan kelas VII C sebagai kelas kontrol. Pen- gumpulan data dalam penelitian ini menggunakan metode tes, observasi dan demonstrasi. Data penelitian yang terkumpul digunakan analisis uji t-test.Berdasarkan hasil t-test, dihasilkan bahwa t hitung = 2,947 dan ttabel  = 1,68 dengan taraf nyata 5% Karena t hitung > ttabel maka data tersebut signifikan. Sedangkan untuk uji hipotesis pihak kanan dibandingkan dengan KKM diperoleh thitung  = 9,2876 dan ttabel  = 1,714 maka penggunaan lingkun- gan sebagai sumber belajar dapat  mencapai  KKM yang  telah ditentukan yaitu 70. Dengan demikian pembelajaran IPA menggunakan lingkungan sebagai sumber belajar efektif terhadap hasil belajar siswa Kelas VII  SMP N 2 Pringapus   Kabupaten   Semarang pada mata pelajaran IPA   pokok bahasan.

The Application Model of Learning Cycle 5e in Subject Matter of Magnitude and Derivative at Class VII Junior High School 1 Sengah Temila

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Ira Nofita Sari

2016-10-01

Penelitian ini bertujuan untuk mengetahui penerapan model learning cycle 5 e pada materi besaran pokok dan turunankelas VII SMP Negeri 1 Sengah Temila. Penelitian ini termasuk penelitian quasi eksperiment dengan rancangan posttest only design control design. Alat pengumpul data yang digunakan adalah tes pilihan jamak. Hipotesis diuji menggunakanuji t satu pihak. Berdasarkan hasil analisis data disimpulkan bahwa: (1 hasil belajar siswa setelah diterapkan model learning cycle 5 e pada materi besaran pokok dan turunan kelas VII SMP Negeri 1 Sengah Temilatergolong baik, (2 hasil belajar siswa setelah diterapkan model learning cycle 5 e pada materi besaran pokok dan turunan kelas VII SMP Negeri 1 Sengah Temilatergolong kurang, dan (3 hasil belajar siswa setelah diterapkan model learning cycle 5 e lebih baik daripada hasil belajar siswa setelah diterapkan model pembelajaran konvensional pada materi besaran pokok dan turunan kelas VII SMP Negeri 1 Sengah Temila. Kata kunci: besaran pokok dan turunan, hasil belajar, model learning cycle 5e

Molecular modeling

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Aarti Sharma

2009-01-01

Full Text Available The use of computational chemistry in the development of novel pharmaceuticals is becoming an increasingly important tool. In the past, drugs were simply screened for effectiveness. The recent advances in computing power and the exponential growth of the knowledge of protein structures have made it possible for organic compounds to be tailored to decrease the harmful side effects and increase the potency. This article provides a detailed description of the techniques employed in molecular modeling. Molecular modeling is a rapidly developing discipline, and has been supported by the dramatic improvements in computer hardware and software in recent years.

Lysogenic Streptococcus suis isolate SS2-4 containing prophage SMP showed increased mortality in zebra fish compared to the wild-type isolate.

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Fang Tang

Full Text Available Streptococcus suis (S. suis infection is considered to be a major problem in the swine industry worldwide. Based on the capsular type, 33 serotypes of S. suis have been described, with serotype 2 (SS2 being the most frequently isolated from diseased piglets. Little is known, however, about the pathogenesis and virulence factors of S. suis. Research on bacteriophages highlights a new area in S. suis research. A S. suis serotype 2 bacteriophage, designated SMP, has been previously isolated in our laboratory. Here, we selected a lysogenic isolate in which the SMP phage was integrated into the chromosome of strain SS2-4. Compared to the wild-type isolate, the lysogenic strain showed increased mortality in zebra fish. Moreover the sensitivity of the lysogenic strain to lysozyme was seven times higher than that of the wild-type.

Molecular Modelling

Directory of Open Access Journals (Sweden)

Aarti Sharma

2009-12-01

Full Text Available

PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE SNOWBALL THROWING TERHADAP HASIL BELAJAR SISWA PADA KONSEP SALING KETERGANTUNGAN DALAM EKOSISTEM DI KELAS VII SMP NEGERI 18 PEKANBARU TAHUN AJARAN 2014 / 2015

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Jumiati Jumiati

2017-07-01

Full Text Available The aim of this research was to find out the effect of cooperative learning type snowballthrowing to improve student learning achievement on the reliance mutualin in theecosystem concept. The research was conducted at SMP Negeri 18 Pekanbaru at firstsemester in academic years 2014 / 2015. Design of the research was quasi-experimental,The Matching Only Pretest – Posttest Control Group Design. Sample of the research wastaken two classes with the number of students in each 40 people who were taken by usingsimple random sampling technique. The data were collected by using pretest, posttest andteacher’s and students’ activities observation sheets. The data analysis technique used inthis research was 2 sample independent t test, if the data were normal and homogen. Themean N-gain experimental class was 0.72 high category and the control class was 0.44medium category. Based on the result of statistical test that there were significantdifferences between the mean N-Gain experimental class and control class. Thereby canbe conluded that there were significant application of cooperative learning type snowballthrowing to improve student learning achievement on the reliance mutualin in theecosystem concept class VII SMPN 18 pekanbaru academic year 2014 / 2015.Key words : snowball throwing, learning achievement, ecosystem.

Faktor-Faktor yang Berhubungan dengan Usia Menarche Siswi SMP Adabiah

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Fitrah Umi Mutasya

2016-01-01

Full Text Available AbstrakMenarche (menars adalah haid pertama dari uterus yang merupakan awal dari fungsi menstruasi dan tanda telah terjadinya pubertas pada remaja putri. Pada dekade terakhir menunjukkan kecenderungan pergeseran usia menars ke arah umur yang lebih muda. Tujuan penelitian ini adalah menentukan faktor-faktor yang berhubungan dengan usia menars. Jenis penelitian ini adalah analitik observasional dalam bentuk rancangan cross sectional study. Populasi dalam penelitian ini adalah seluruh siswi SMP Adabiah kelas VII dan VIII tahun ajaran 2012/2013. Jumlah sampel sebanyak 72 siswi yang diambil secara Simple Random Sampling. Data dikumpulkan dengan angket dan pengukuran tinggi dan berat badan responden. Pengolahan data dilakukan secara komputerisasi dan analisis dengan uji chi-square pada α = 0,05. Hasil penelitian didapatkan bahwa usia menars rata-rata siswi SMP Adabiah adalah 12,29 ± 0,49 tahun. Uji statistik menunjukkan terdapat hubungan yang bermakna antara tingkat pendapatan per kapita dan status gizi dengan usia menars sedangkan tingkan pendidikan orang tua dan paparan media massa tidak terdapat hubungan yang bermakna dengan usia menars.Kata kunci: usia menars, pendapatan per kapita, status gizi AbstractMenarche is the first menstruation or bleeding of the uterus that is the beginning of the menstrual function and mark the occurrence of puberty in young girls. In the past decade shows a shift in the age of menarche trend toward younger age. The objective of this study was to determine the associated factors to age of menarche. This type of research is observational analytic with cross sectional study design. The population in this study were all junior high school students of class VII and VIII academic year 2012/2013. The total sample of 72 student were taken by simple random sampling. Data were collected by questionnaire and measurement of height and weight. Data was analyzed  by chi-square test at α = 0,005. The result showed that the

Comparing the OpenMP, MPI, and Hybrid Programming Paradigm on an SMP Cluster

Science.gov (United States)

Jost, Gabriele; Jin, Hao-Qiang; anMey, Dieter; Hatay, Ferhat F.

2003-01-01

Clusters of SMP (Symmetric Multi-Processors) nodes provide support for a wide range of parallel programming paradigms. The shared address space within each node is suitable for OpenMP parallelization. Message passing can be employed within and across the nodes of a cluster. Multiple levels of parallelism can be achieved by combining message passing and OpenMP parallelization. Which programming paradigm is the best will depend on the nature of the given problem, the hardware components of the cluster, the network, and the available software. In this study we compare the performance of different implementations of the same CFD benchmark application, using the same numerical algorithm but employing different programming paradigms.

KEEFEKTIFAN PENDEKATAN OPEN-ENDED DAN PROBLEM SOLVING PADA PEMBELAJARAN BANGUN RUANG SISI DATAR DI SMP

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Nuning Melianingsih

2015-11-01

Full Text Available Penelitian ini bertujuan untuk menentukan keefektifan dan perbandingan keefektifan dari pendekatan open-ended dan problem solving pada pembelajaran bangun ruang sisi datar ditinjau dari pencapaian kemampuan penalaran, pemecahan masalah, dan komunikasi matematis. Penelitian ini adalah quasi experiment dengan desain pretest-posttest nonequivalent group design. Populasi penelitian mencakup seluruh siswa kelas VIII SMP Negeri 1 Pandak, Bantul, Yogyakarta. Selanjutnya dengan memilih secara acak dari keseluruhan kelas tersebut, terpilih kelas VIII F dan VIII G sebagai sampel penelitian. Untuk menguji keefektifan masing-masing pendekatan pembelajaran digunakan uji one sample t-test. Untuk menguji bahwa pendekatan open-ended lebih efektif daripada pendekatan problem solving, data dianalisis menggunakan MANOVA yang dilanjutkan dengan uji t-Bonferroni. Hasil penelitian menunjukkan bahwa kedua pendekatan pembelajaran efektif ditinjau dari masing-masing aspek, dan pendekatan open-ended lebih efektif daripada pendekatan problem solving pada pembelajaran bangun ruang sisi datar ditinjau dari pencapaian kemampuan penalaran, pemecahan masalah, dan komunikasi matematis di SMP. Kata Kunci: pendekatan open-ended, pendekatan problem solving, kemampuan penalaran, kemampuan pemecahan masalah, kemampuan komunikasi matematis   THE EFFECTIVENESS OF OPEN-ENDED AND PROBLEM SOLVING APPROACH IN MATTER OF FLAT SIDE CONSTRUCT IN JUNIOR HIGH SCHOOL Abstract The aims of this research are to decide the effectiveness and the comparison of the effectiveness of open-ended and problem solving approach toward matter of flat side construct lesson viewed from achivement of reasoning ability, problem solving and mathematics communication. This study was a quasi experimental study using the pretest-posttest nonequivalent group design. The research population covered the entire VIII class students’ of SMP Negeri 1 Pandak, Bantul, Yogyakarta. From the population, classes of VIII F and

POLA ASUH ORANG TUA, KONSEP DIRI, MOTIVASI DIRI, IKLIM SEKOLAH, DAN KESADARAN EMOSI SISWA SMP

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Esther Heydemans

2016-02-01

Full Text Available Abstract: Patterns of Parenting, Self-concept, Self-motivation, School Climate, and Emotional Awareness of Students at State Junior High Schools. The study tries to investigate the correlation between patterns of foster parents, self concept, self motivation, school climate and emotional awareness of the students at State Junior High School in Malang. Using multiple regression analysis, it is concluded  that patterns of foster parents, self motivation, school climate have effective significant contribution to emotional awareness both individually and in groups. Meanwhile, self concept has no significant effect. As a whole the effective contribution of the patterns of foster parents, self concept, self motivation, school climate to emotional awareness is 0.57 or 57%, it means that the remaining 43% of emotional awareness cannot be explained. Abstrak: Pola Asuh Orang Tua, Konsep Diri, Motivasi Diri, Iklim Sekolah, dan Kesadaran Emosi Siswa SMP. Penelitian ini mencoba untuk menjelaskan hubungan antara pola asuh orang tua, konsep diri, motivasi diri, iklim sekolah dan kesadaran emosi siswa SMP Negeri di kota Malang. Dengan menggunakan analisis multiple regresi disimpulkan bahwa pola asuh orang tua, motivasi diri, dan iklim sekolah memberi kontribusi yang signifikan terhadap kesadaran emosi, baik secara individu dan kelompok. Sementara itu konsep diri mempunyai pengaruh, tetapi tidak signifikan. Secara keseluruhan kontribusi efektif dari pola asuh orang tua, konsep diri, motivasi diri, iklim sekolah terhadap kesdaran emosi adalah 0.57 (57%. Hal itu berarti bahwa ada 43% faktor lain yang mempengaruhi kesadaran emosi, tetapi tidak bisa dijelaskan.

PENGEMBANGAN MEDIA PEMBELAJARAN KOSAKATA BAHASA INGGRIS BERBANTUAN KOMPUTER UNTUK SISWA SMP KELAS VII

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Bastani Bastani

2014-05-01

Full Text Available Penelitian ini bertujuan: (1 menghasilkan media pembelajaran kosakata bahasa Inggris berbantuan komputer untuk siswa SMP kelas VII; dan (2 mengetahui kelayakan media pada aspek materi, pemrograman, dan tampilan. Penelitian ini adalah penelitian dan pengembangan dengan menggunakan model pengembangan Borg & Gall dan Alessi & Trollip’s yang telah dimodifikasi. Penelitian ini dilaksanakan melalui tiga tahap, yaitu perencanaan, desain, dan pengembangan. Tahap perencanaan meliputi penetapan tujuan dan penganalisisan kebutuhan. Tahap desain meliputi penyelenggaraan focus group discussion, pembuatan flowchart, storyboard, penyiapan materi, dan bahan pendukung. Tahap pengembangan meliputi pembuatan aplikasi berdasarkan flowchart dan storyboard, validasi ahli dan validasi pengguna. Instrumen penelitian yang digunakan adalah kuesioner/angket dan tes. Hasil penelitian dan pengembangan ini adalah: (1 produk media pembelajaran kosakata bahasa Inggris berbantuan komputer dalam bentuk CD pembelajaran dan print out produk; dan (2 kelayakan media ditinjau dari aspek materi termasuk kriteria sangat layak dengan rata-rata skor 4,47 pada skala lima, aspek pemrograman termasuk kriteria sangat layak dengan rata-rata skor 4,21 dan aspek tampilan termasuk kriteria sangat layak dengan rata-rata skor 4,44. Kata kunci: pengembangan, media pembelajaran, kosakata, pembelajaran berbantuan komputer.

Magnetohydrodynamic Models of Molecular Tornadoes

Science.gov (United States)

Au, Kelvin; Fiege, Jason D.

2017-07-01

Recent observations near the Galactic Center (GC) have found several molecular filaments displaying striking helically wound morphology that are collectively known as molecular tornadoes. We investigate the equilibrium structure of these molecular tornadoes by formulating a magnetohydrodynamic model of a rotating, helically magnetized filament. A special analytical solution is derived where centrifugal forces balance exactly with toroidal magnetic stress. From the physics of torsional Alfvén waves we derive a constraint that links the toroidal flux-to-mass ratio and the pitch angle of the helical field to the rotation laws, which we find to be an important component in describing the molecular tornado structure. The models are compared to the Ostriker solution for isothermal, nonmagnetic, nonrotating filaments. We find that neither the analytic model nor the Alfvén wave model suffer from the unphysical density inversions noted by other authors. A Monte Carlo exploration of our parameter space is constrained by observational measurements of the Pigtail Molecular Cloud, the Double Helix Nebula, and the GC Molecular Tornado. Observable properties such as the velocity dispersion, filament radius, linear mass, and surface pressure can be used to derive three dimensionless constraints for our dimensionless models of these three objects. A virial analysis of these constrained models is studied for these three molecular tornadoes. We find that self-gravity is relatively unimportant, whereas magnetic fields and external pressure play a dominant role in the confinement and equilibrium radial structure of these objects.

Magnetohydrodynamic Models of Molecular Tornadoes

Energy Technology Data Exchange (ETDEWEB)

Au, Kelvin; Fiege, Jason D., E-mail: fiege@physics.umanitoba.ca [Department of Physics and Astronomy, University of Manitoba Winnipeg, MB R3T 2N2 (Canada)

2017-07-10

Recent observations near the Galactic Center (GC) have found several molecular filaments displaying striking helically wound morphology that are collectively known as molecular tornadoes. We investigate the equilibrium structure of these molecular tornadoes by formulating a magnetohydrodynamic model of a rotating, helically magnetized filament. A special analytical solution is derived where centrifugal forces balance exactly with toroidal magnetic stress. From the physics of torsional Alfvén waves we derive a constraint that links the toroidal flux-to-mass ratio and the pitch angle of the helical field to the rotation laws, which we find to be an important component in describing the molecular tornado structure. The models are compared to the Ostriker solution for isothermal, nonmagnetic, nonrotating filaments. We find that neither the analytic model nor the Alfvén wave model suffer from the unphysical density inversions noted by other authors. A Monte Carlo exploration of our parameter space is constrained by observational measurements of the Pigtail Molecular Cloud, the Double Helix Nebula, and the GC Molecular Tornado. Observable properties such as the velocity dispersion, filament radius, linear mass, and surface pressure can be used to derive three dimensionless constraints for our dimensionless models of these three objects. A virial analysis of these constrained models is studied for these three molecular tornadoes. We find that self-gravity is relatively unimportant, whereas magnetic fields and external pressure play a dominant role in the confinement and equilibrium radial structure of these objects.

KEBIASAAN SARAPAN, STATUS GIZI, DAN KUALITAS HIDUP REMAJA SMP BOSOWA BINA INSANI BOGOR

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Ilyatun Niswah

2014-11-01

Full Text Available ABSTRACTThe objective of this study was to examine the association between breakfast habits, nutritional status, and health related quality of life of adolescents in Bosowa Bina Insani Junior High School Bogor. A cross sectional study was conducted and simple random sampling was used to determine the subjects. Subjects were 60 adolescent students of Bosowa Bina Insani Junior High School Bogor aged 13—15 years old. The study found there was no significant difference in nutritional status between breakfast skippers and breakfast eaters (p>0.05. However, regular breakfast eaters were more likely to have lower body weight (r=-0.160, p=0.222. There was no significant difference of health related quality of life based on nutritional status (p>0.05. Breakfast eaters tended to have better quality of life than breakfast skippers even though there was no significant difference between them (p>0.05.Keywords: adolescents, breakfast habits, food consumption, health related quality of life, nutritionalstatusABSTRAKPenelitian ini bertujuan mengkaji hubungan kebiasaan sarapan, status gizi, dan kualitas hidup pada remaja SMP Bosowa Bina Insani Bogor. Desain penelitian ini adalah cross sectional dengan penarikan subjek secara simple random sampling. Subjek berjumlah 60 remaja berusia 13—15 tahun yang merupakan siswa-siswi SMP Bosowa Bina Insani Bogor. Hasil penelitian menunjukkan tidak terdapat perbedaan signifikan status gizi berdasarkan kebiasaan sarapan (p>0.05 namun terdapat kecenderungan semakin sering konsumsi sarapan, berat badan semakin menurun (r=-0.160, p=0.222. Tidak terdapat perbedaan signifikan kualitas hidup berdasarkan status gizi (p>0.05. Kualitas hidup pada kelompok yang biasa sarapan cenderung lebih tinggi dibandingkan kelompok yang tidak biasa sarapan, namun tidak terdapat perbedaan signifikan secara statistik (p>0.05.Kata kunci: kebiasaan sarapan, konsumsi pangan, kualitas hidup, remaja, status gizi

Biomass viability: An experimental study and the development of an empirical mathematical model for submerged membrane bioreactor.

Science.gov (United States)

Zuthi, M F R; Ngo, H H; Guo, W S; Nghiem, L D; Hai, F I; Xia, S Q; Zhang, Z Q; Li, J X

2015-08-01

This study investigates the influence of key biomass parameters on specific oxygen uptake rate (SOUR) in a sponge submerged membrane bioreactor (SSMBR) to develop mathematical models of biomass viability. Extra-cellular polymeric substances (EPS) were considered as a lumped parameter of bound EPS (bEPS) and soluble microbial products (SMP). Statistical analyses of experimental results indicate that the bEPS, SMP, mixed liquor suspended solids and volatile suspended solids (MLSS and MLVSS) have functional relationships with SOUR and their relative influence on SOUR was in the order of EPS>bEPS>SMP>MLVSS/MLSS. Based on correlations among biomass parameters and SOUR, two independent empirical models of biomass viability were developed. The models were validated using results of the SSMBR. However, further validation of the models for different operating conditions is suggested. Copyright © 2015 Elsevier Ltd. All rights reserved.

A stress-induced phase transition model for semi-crystallize shape memory polymer

Science.gov (United States)

Guo, Xiaogang; Zhou, Bo; Liu, Liwu; Liu, Yanju; Leng, Jinsong

2014-03-01

The developments of constitutive models for shape memory polymer (SMP) have been motivated by its increasing applications. During cooling or heating process, the phase transition which is a continuous time-dependent process happens in semi-crystallize SMP and the various individual phases form at different temperature and in different configuration. Then, the transformation between these phases occurred and shape memory effect will emerge. In addition, stress applied on SMP is an important factor for crystal melting during phase transition. In this theory, an ideal phase transition model considering stress or pre-strain is the key to describe the behaviors of shape memory effect. So a normal distributed model was established in this research to characterize the volume fraction of each phase in SMP during phase transition. Generally, the experiment results are partly backward (in heating process) or forward (in cooling process) compared with the ideal situation considering delay effect during phase transition. So, a correction on the normal distributed model is needed. Furthermore, a nonlinear relationship between stress and phase transition temperature Tg is also taken into account for establishing an accurately normal distributed phase transition model. Finally, the constitutive model which taking the stress as an influence factor on phase transition was also established. Compared with the other expressions, this new-type model possesses less parameter and is more accurate. For the sake of verifying the rationality and accuracy of new phase transition and constitutive model, the comparisons between the simulated and experimental results were carried out.

PENDIDIKAN KARAKTER DALAM MATA PELAJARAN PENDIDIKAN AGAMA ISLAM DI SMP 3 PEKALONGAN (Kajian atas Kurikulum dan Proses Pembelajaran

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. Maemonah

2012-10-01

Full Text Available Even though character building as an autonomous subject among student does not exist in secondary school, Islamic Education (PAI, as one of the subjects in school related to character building, has to play its role in building students’ character. This study aims to reveal the problems related to PAI learning process in SMP 3 and its role in building students’ noble character. This study was qualitative using observational case studies. The data were obtained through interviews, questionnaires, and documents and were analyzed using qualitative analysis techniques with the inductive approach. The documents were such legal decisions of officials in Educational Ministry, the syllabi, curriculums, and teaching planning (RPP. The result shows that PAI learning has an important role in building students’ noble character if it is supported by competent lecturers, good inputs, adequate materials, and good processes. Character building learning was taught integrated and aimed to shape noble character among the students of SMP 3 Pekalongan. It was accommodated in PAI learning, citizenship learning and local contain subject, such as Javanese language and Cookery Learning. Unfortunately, the sustainability and comprehensiveness of character building learning in PAI curriculum were not seriously attended. Nevertheless, they were taught integrated in pilot project program and evaluated gradually and comprehensively.

A combined reaction class approach with integrated molecular orbital+molecular orbital (IMOMO) methodology: A practical tool for kinetic modeling

International Nuclear Information System (INIS)

Truong, Thanh N.; Maity, Dilip K.; Truong, Thanh-Thai T.

2000-01-01

We present a new practical computational methodology for predicting thermal rate constants of reactions involving large molecules or a large number of elementary reactions in the same class. This methodology combines the integrated molecular orbital+molecular orbital (IMOMO) approach with our recently proposed reaction class models for tunneling. With the new methodology, we show that it is possible to significantly reduce the computational cost by several orders of magnitude while compromising the accuracy in the predicted rate constants by less than 40% over a wide range of temperatures. Another important result is that the computational cost increases only slightly as the system size increases. (c) 2000 American Institute of Physics

Characterization of biofoulants illustrates different membrane fouling mechanisms for aerobic and anaerobic membrane bioreactors

KAUST Repository

Xiong, Yanghui; Harb, Moustapha; Hong, Pei-Ying

2015-01-01

efficiency, the fouling mechanisms were different. Molecular weight (MW) fingerprint profiles showed that a majority of fragments in anaerobic soluble microbial products (SMP) were retained by the membrane and some fragments were present in both SMP

Test of models for replication of SV40 DNA following UV irradiation

International Nuclear Information System (INIS)

Barnett, S.W.

1983-01-01

The replication of SV40 DNA immediately after irradiation of infected monkey cells has been examined. SV40 DNA synthesis is inhibited in a UV fluence-dependent fashion, and the synthesis of completely replicated (Form I) SV40 molecules is more severely inhibited than is total SV40 DNA synthesis. Two models for DNA replication-inhibition have been tested. Experimental results have been compared to those predicted by mathematical models derived to describe two possible molecular mechanisms of replication inhibition. No effect of UV irradiation on the uptake and phosphorylation of 3 H-thymidine nor on the size of the intracellular deoxythymidine triphosphate pool of SV40-infected cells have been observed, validating the use of 3 H-thymidine incorporation as a measure of DNA synthesis in this system. In vitro studies have been performed to further investigate the mechanism of dimer-specific inhibition of completion of SV40 DNA synthesis observed in in vivo. The results of these studies are consistent with a mechanism of discontinuous synthesis past dimer sites, but it is equally possible that the mechanism of DNA replication of UV-damaged DNA in the in vitro system is different from that which occurs in vivo

Persepsi Siswa terhadap Komunikasi Guru Pembimbing dalam Pelaksanaan Layanan Informasi (Studi Deskriptif terhadap Siswa SMP N 26 Padang

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ines novianti

2013-03-01

Full Text Available In fact at the school execution of information service less is effective caused by perception of student to communications teacher counsellor. Target of research lay open perception of student to communications teacher counsellor in execution of information service in SMP N 26 Field. This Research use quantitative approach of descriptive type, intake of Stratified Sampling sampel. result of research indicate that perception of student to communications teacher counsellor in execution of good enough information service

Faktor-Faktor yang Memengaruhi Asertifitas Remaja dalam Perilaku Seksual di SMP Negeri 1 Hinai Kabupaten Langkat Tahun 2013

OpenAIRE

Humaira, Wardati

2015-01-01

Sexual behavior in teenagers tends to be increasing. One of the life skills needed to be applied by the teenagers is the skill of how to be assertive. The factors influencing the assertiveness are culture, self-esteem, parents’ parenting pattern, peers, knowledge, self-efficacy, and information media. The purpose of this study was to find out the factors influencing the teenagers’ assertiveness in sexual behavior at SMP (Junior High School) Negeri I Hinai, Langkat District, in 2013. The po...

Open source molecular modeling.

Science.gov (United States)

Pirhadi, Somayeh; Sunseri, Jocelyn; Koes, David Ryan

2016-09-01

The success of molecular modeling and computational chemistry efforts are, by definition, dependent on quality software applications. Open source software development provides many advantages to users of modeling applications, not the least of which is that the software is free and completely extendable. In this review we categorize, enumerate, and describe available open source software packages for molecular modeling and computational chemistry. An updated online version of this catalog can be found at https://opensourcemolecularmodeling.github.io. Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

Cell and molecular biology of simian virus 40: implications for human infections and disease

Science.gov (United States)

Butel, J. S.; Lednicky, J. A.

1999-01-01

Simian virus 40 (SV40), a polyomavirus of rhesus macaque origin, was discovered in 1960 as a contaminant of polio vaccines that were distributed to millions of people from 1955 through early 1963. SV40 is a potent DNA tumor virus that induces tumors in rodents and transforms many types of cells in culture, including those of human origin. This virus has been a favored laboratory model for mechanistic studies of molecular processes in eukaryotic cells and of cellular transformation. The viral replication protein, named large T antigen (T-ag), is also the viral oncoprotein. There is a single serotype of SV40, but multiple strains of virus exist that are distinguishable by nucleotide differences in the regulatory region of the viral genome and in the part of the T-ag gene that encodes the protein's carboxyl terminus. Natural infections in monkeys by SV40 are usually benign but may become pathogenic in immunocompromised animals, and multiple tissues can be infected. SV40 can replicate in certain types of simian and human cells. SV40-neutralizing antibodies have been detected in individuals not exposed to contaminated polio vaccines. SV40 DNA has been identified in some normal human tissues, and there are accumulating reports of detection of SV40 DNA and/or T-ag in a variety of human tumors. This review presents aspects of replication and cell transformation by SV40 and considers their implications for human infections and disease pathogenesis by the virus. Critical assessment of virologic and epidemiologic data suggests a probable causative role for SV40 in certain human cancers, but additional studies are necessary to prove etiology.

Parallel peak pruning for scalable SMP contour tree computation

Energy Technology Data Exchange (ETDEWEB)

Carr, Hamish A. [Univ. of Leeds (United Kingdom); Weber, Gunther H. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Davis, CA (United States); Sewell, Christopher M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Ahrens, James P. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2017-03-09

As data sets grow to exascale, automated data analysis and visualisation are increasingly important, to intermediate human understanding and to reduce demands on disk storage via in situ analysis. Trends in architecture of high performance computing systems necessitate analysis algorithms to make effective use of combinations of massively multicore and distributed systems. One of the principal analytic tools is the contour tree, which analyses relationships between contours to identify features of more than local importance. Unfortunately, the predominant algorithms for computing the contour tree are explicitly serial, and founded on serial metaphors, which has limited the scalability of this form of analysis. While there is some work on distributed contour tree computation, and separately on hybrid GPU-CPU computation, there is no efficient algorithm with strong formal guarantees on performance allied with fast practical performance. Here in this paper, we report the first shared SMP algorithm for fully parallel contour tree computation, withfor-mal guarantees of O(lgnlgt) parallel steps and O(n lgn) work, and implementations with up to 10x parallel speed up in OpenMP and up to 50x speed up in NVIDIA Thrust.

Coherent and incoherent giant dipole resonance γ-ray emission induced by heavy ion collisions: Study of the 40Ca+48Ca system by means of the constrained molecular dynamics model

International Nuclear Information System (INIS)

Papa, Massimo; Cardella, Giuseppe; Bonanno, Antonio; Pappalardo, Giuseppe; Rizzo, Francesca; Amorini, Francesca; Bonasera, Aldo; Di Pietro, Alessia; Figuera, Pier Paolo; Tudisco, Salvatore; Maruyama, Toshiki

2003-01-01

Coherent and incoherent dipolar γ-ray emission is studied in a fully dynamical approach by means of the constrained molecular dynamics model. The study is focused on the system 40 Ca+ 48 Ca for which recently experimental data have been collected at 25 MeV/nucleon. The approach allows us to explain the experimental results in a self-consistent way without using statistical or hybrid models. Moreover, calculations performed at higher energy show interesting correlations between the fragment formation process, the degree of collectivity, and the coherence degree of the γ-ray emission process

PENERAPAN JIGSAW PUZZLE COMPETITION DALAM PEMBELAJARAN KONTEKSTUAL UNTUK MENINGKATKAN MINAT DAN HASIL BELAJAR FISIKA SISWA SMP

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D. Yulianti

2012-01-01

Full Text Available Untuk mengatasi kurangnya minat dan hasil belajar fisika siswa dilakukan penelitian melalui kegiatan pembelajaran fisikakontekstual berbantuan jigsaw puzzle competititon. Subjek penelitian ini adalah siswa kelas VII H SMP Negeri 18 Semarang.Penelitian ini telah dilakukan pembelajaran dengan pendekatan kontekstual berbantuan jigsaw puzzle competition. Hasilpenelitian menunjukkan bahwa pembelajaran kontekstual berbantuan jigsaw puzzle competition mampu meningkatan minat danhasil belajar siswa kelas VII H SMPNegeri 18 Semarang tahun pelajaran 2008/2009 secara signifikan. Agar lebih efektif sebaiknyadikembangkan pembelajaran kontekstual dengan metode lain agar diperoleh peningkatan minat dan hasil belajar Model ini perludiaplikasikan dalam pembelajaran fisika untuk materi yang lain. To overcome the problem of lack of students' interest as well as their achievements a Jigsaw Puzzle Competition in physicscontextual learning process was done. The students from VIIHclass of Junior High School 18 Semarang academic year 2008/2009were chosen as the subjects. The result of this research shows that contextual teaching and learning using Jigsaw PuzzleCompetition approach was not only increase the students' interest but also improve their achievements. In order to get moreeffective result, it is necessary to develop contextual teaching and learning by combining them with other method. Because of thegreat benefit of this model, it is necessary to apply this model to other physics learning concepts.Keywords: Jigsaw Puzzle Competition, contextual, interest;

Dimer formation enhances structural differences between amyloid β-protein (1-40 and (1-42: an explicit-solvent molecular dynamics study.

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Bogdan Barz

Full Text Available Amyloid β-protein (Aβ is central to the pathology of Alzheimer's disease. A 5% difference in the primary structure of the two predominant alloforms, Aβ(1-40 and Aβ(1-42, results in distinct assembly pathways and toxicity properties. Discrete molecular dynamics (DMD studies of Aβ(1-40 and Aβ(1-42 assembly resulted in alloform-specific oligomer size distributions consistent with experimental findings. Here, a large ensemble of DMD-derived Aβ(1-40 and Aβ(1-42 monomers and dimers was subjected to fully atomistic molecular dynamics (MD simulations using the OPLS-AA force field combined with two water models, SPCE and TIP3P. The resulting all-atom conformations were slightly larger, less compact, had similar turn and lower β-strand propensities than those predicted by DMD. Fully atomistic Aβ(1-40 and Aβ(1-42 monomers populated qualitatively similar free energy landscapes. In contrast, the free energy landscape of Aβ(1-42 dimers indicated a larger conformational variability in comparison to that of Aβ(1-40 dimers. Aβ(1-42 dimers were characterized by an increased flexibility in the N-terminal region D1-R5 and a larger solvent exposure of charged amino acids relative to Aβ(1-40 dimers. Of the three positively charged amino acids, R5 was the most and K16 the least involved in salt bridge formation. This result was independent of the water model, alloform, and assembly state. Overall, salt bridge propensities increased upon dimer formation. An exception was the salt bridge propensity of K28, which decreased upon formation of Aβ(1-42 dimers and was significantly lower than in Aβ(1-40 dimers. The potential relevance of the three positively charged amino acids in mediating the Aβ oligomer toxicity is discussed in the light of available experimental data.

PENINGKATAN PEMAHAMAN KONSEP DAN KOMPETENSI STRATEGIS MATEMATIS SISWA SMP DENGAN PENDEKATAN METAPHORICAL THINKING

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M. Afrilianto

2012-09-01

Full Text Available Penelitian ini bertujuan untuk mendeskripsikan dan menelaah peningkatan  pemahaman konsep dan kompetensi strategis matematis antara siswa yang memperoleh pembelajaran dengan pendekatan metaphorical thinking, dengan siswa yang memperoleh pembelajaran biasa. Jenis penelitian ini merupakan kuasi eksperimen. Populasi penelitian ini adalah seluruh siswa kelas VIII SMP Negeri 12 Bandung. Sampel dalam penelitian ini dipilih sebanyak 2 kelas dari kelas VIII. Kelas eksperimen memperoleh pembelajaran dengan pendekatan metaphorical thinking, dan kelas kontrol memperoleh pembelajaran biasa. Instrumen penelitian meliputi tes pemahaman konsep dan kompetensi strategis matematis, angket, pedoman observasi dan pedoman wawancara. Pengolahan data peningkatan pemahaman konsep dan kompetensi strategis matematis menggunakan uji-t dan uji Mann-Whitney. Hasil penelitian menunjukkan bahwa (1 Terdapat perbedaan peningkatan pemahaman konsep dan kompetensi strategis matematis antara siswa yang memperoleh pembelajaran dengan pendekatan metaphorical thinking, dengan siswa yang memperoleh pembelajaran biasa; (2 Siswa menunjukkan sikap yang positif terhadap pembelajaran dengan pendekatan metaphorical thinking.   Kata Kunci: pendekatan metaphorical thinking, pemahaman konsep matematis, kompetensi strategis matematis.   This research aim to describe and to analyze the enhancement of mathematical conceptual understanding and strategic competence between students in metaphorical thinking approach and conventional learning. This kind of research is a quasi experiment. The populations of this research are all of the students of VIII grade in SMP Negeri 12 Bandung. The samples of this research are by choosing 2 classes of VIII grade. The experiment class obtains the metaphorical thinking approach, and the control class obtains the conventional learning. The research of data is obtained by giving a mathematical conceptual understanding and strategic competence test, questionnaire

[Effects on Stress, Problem Solving Ability and Quality of Life of as a Stress Management Program for Hospitalized Schizophrenic Patients: Based on the Stress, Appraisal-Coping Model of Lazarus & Folkman].

Science.gov (United States)

Park, Sun Ah; Sung, Kyung Mi

2016-08-01

The study was done to evaluate the effects a Stress Management Program (SMP) on stress, problem solving skills, and quality of life for hospitalized patients with Schizophrenia. A mixed method design was used: a combination of a repeated-measure design with a non-equivalent control group and qualitative data collection. The participants were 40 patients with schizophrenia admitted in three psychiatric hospitals. The experimental group (n=20) received the SMP twice a week for a total of 8 weeks. Study results revealed that the SMP was effective for stress (F=321.02, pproblem solving ability (F=246.28, peffective strategy to reduce patients' hospitalization stress, and improve problem solving skills and quality of life. Therefore, it is recommended that mental health nurses use this stress management program in clinical practice to assist adaptation to hospitalization for persons with schizophrenia.

Study of fuel element characteristic of SM and SMP (SM-PRIMA) fuel assemblies

International Nuclear Information System (INIS)

Klinov, A.V.; Kuprienko, V.A.; Lebedev, V.A.; Makhin, V.M.; Tuchnin, L.M.; Tsykanov, V.A.

1999-01-01

The paper discusses the techniques and results of reactor tests and post-reactor investigations of the SM reactor fuel elements and fuel elements developed in the process of designing the specialized PRIMA test reactor with the SM reactor fuel elements used as a prototype and which are referred to as the SMP fuel elements. The behavior of fuel elements under normal operating conditions and under deviation from normal operating conditions was studied to verify the calculation techniques, to check the calculation results during preparation of the SM reactor safety substantiation report and to estimate the possibility of using such fuel elements in other projects. During tests of fuel rods under deviation from normal operating conditions their advantages were shown over fuel elements, the components of which were produced using the Al-based alloys. (author)

Profil Penalaran Proporsional Siswa SMP dalam Memecahkan Masalah Matematika Berdasarkan Gaya Kognitif Sistematis dan Intuitif

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Akhmad Faisal Hidayat

2017-12-01

Full Text Available Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif. Tujuan penelitian ini adalah mendeskripsikan profil penalaran proporsional siswa SMP dalam memecahkan masalah matematika berdasarkan gaya kognitif sistematis dan intuitif. Penelitian ini dilakukan di kelas IX SMP Al-Muslim Sidoarjo pada tahun ajaran 2016/2017. Subjek penelitian ini adalah seorang siswa bergaya kognitif sistematis dan seorang siswa bergaya kognitif sistematis. Alat pengumpul data berupa Tes Gaya Kognitif (TGK, Tugas Pemecahan Masalah (TPM, Pedoman wawancara, dan alat rekam audio visual. Data penelitian diperoleh dari pemberian tugas pemecahan masalah dan wawancara  sebanyak dua kali. Wawancara dilakukan untuk mengungkapkan profil penalaran proporsional dalam memecahkan masalah matematika terkait materi perbandingan. Keabsahan data diuji dengan triangulasi waktu. Hasil penelitian menunjukkan kedua subjek gagal membedakan masalah proporsional dan bukan proporsional pada tahap memahami masalah. Pada tahap menyusun rencana, Siswa bergaya kognitif sistematis mengelompokkan bagian-bagian yang sebanding untuk membuat persamaan. Sedangkan siswa bergaya kognitif intuitif membandingkan luas lahan pertama dan kedua, kemudian menyederhanakan perbandingannya. Pada tahap melaksanakan rencana, siswa bergaya kognitif sistematis menggunakan strategi cross product algorithm untuk menemukan solusi. Sedangkan siswa bergaya kognitif intuitif menggunakan strategi build-up method dan factor of change untuk menemukan solusi. Pada tahap memeriksa kembali, Siswa bergaya konitif sistematis dan intuitif mengecek solusi yang mereka peroleh dengan mensubtitusi masing-masing solusi ke persamaan, kemudian melihat nilai perbandingan yang dihasilkan. Jawaban benar jika nilai perbandingan dalam persaamaan tersebut sama.   This research uses descriptive qualitative approach. The purpose of this study was to describe proportional reasoning profile of junior high school student in

A ionic model for molecular units in molten aluminium trichloride and alkali chloroaluminates

International Nuclear Information System (INIS)

Akdeniz, Z.; Pastore, G.; Tosi, M.P.

1996-02-01

A simple ionic model including anion polarizability is developed for the Al 2 Cl 6 molecular dimer and is tested against data on bond lengths, bond angles and vibrational frequencies from experiment and from molecular orbital calculations. The transferability of the model is tested through calculations of structure and vibrational frequencies for the (AlCl 4 ) - and (Al 2 Cl 7 ) - molecular ions as well as for related ionic clusters, the results being compared with available data. Further calculations are reported showing that the Al 2 Cl 6 dimer is strongly stable against fluctuations into ionized states, the fluctuations examined being chlorine exchange between neighbouring dimers and the appearance of ionized products at intermediate stages in the dissociation of the dimer into neutral monomers. The relevance of the results to theoretical understanding of molten chloroaluminates in the acidic range up to pure molten AlCl 3 is discussed. (author). 40 refs, 3 figs, 6 tabs

Analisis Faktor Kerusakan Bahan Pustaka di Perpustakaan SMP Negeri 4 Sungguminasa, Gowa

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St. Ummu Salamah

2015-11-01

Full Text Available The damaged of library collections must be concerned by all type of libraries. It always occured in library, particularly in school libraries. The study will investigate factors that damaged library collections and ways to solve such a case in the library of SMP 4 Sungguminasa, Gowa (a secondary school located in Gowa, South Sulawesi. The data were gathred through direct observations and interviews with staf in the library. The study found that there were kinds of damaged of library collection, which were 1 caused by studens, 2 caused by floods, and 3 caused by insects. In terms of its preservation, the library have some solutions which were 1 determining strict penalties for the library users who have damaged the collections, 2 binding library materials, 3 setting the library room, 4 maka a report to the school authoritative to care of library school, 5 cleaning routinely the library shelves.

HUBUNGAN KEPERCAYAAN DIRI DENGAN PENYESUAIAN SOSIAL PADA REMAJA DI KELAS II SMP MUHAMMADIYAH 1 MALANG

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Aziza Fitriah

2013-05-01

those two variables were independence variable as self confidence and dependence variable as social adaptations. The type of this research was quantitative research (non-experiment. The respondents were 60 students of second grade in SMP Muhammadiyah 1 Malang. The supporting data of this research was gotten by observing and interviewing. And the collecting data technique used linkert scale questionnaire, and data analysis used correlation product moment by Karl Pearson. According to hypothesis test result could be taken the data between self confidence and social adaptation there was a significance correlations. Other wise the higher of teenage self confidence would make the teenage easier to do social adaptations with their social society around them.

EKSPERIMENTASI MODEL PEMBELAJARAN KOOPERATIF TIPE THINK PAIR SHARE (TPS DENGAN PENDEKATAN OPEN-ENDED DITINJAU DARI DISPOSISI MATEMATIS SISWA KELAS VIII SMP NEGERI DI KABUPATEN PURWOREJO

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Zainnur Wijayanto

2015-02-01

Full Text Available prestasi belajar matematika lebih baik, siswa dengan disposisi matematis tinggi, sedang, atau rendah, 4 pada masing-masing kategori disposisi matematis, manakah yang mempunyai prestasi belajar matematika lebih baik, siswa yang dikenai model pembelajaran kooperatif tipe TPS dengan pendekatan open-ended atau pembelajaran langsung. Penelitian ini merupakan penelitian eksperimental semu. Populasi penelitian ini adalah siswa kelas VIII SMP Negeri di Kabupaten Purworejo tahun ajaran 2013/2014. Sampel dalam penelitian ini adalah siswa SMPN 20 Purworejo, SMPN 14 Purworejo, SMPN 13 Purworejo yang diambil secara stratified cluster random sampling. Instrumen yang digunakan untuk mengumpulkan data adalah instrumen tes prestasi belajar matematika, instrumen angket disposisi matematis siswa. Teknik analisis data yang digunakan adalah uji hipotesis menggunakan anava dua jalan dengan sel tak sama. Dari hasil analisis disimpulkan bahwa : 1 prestasi belajar matematika siswa yang diberi pembelajaran dengan model pembelajaran kooperatif tipe TPS dengan pendekatan open-ended lebih baik daripada siswa yang diberi pembelajaran langsung, 2 prestasi belajar matematika siswa dengan disposisi matematis tinggi lebih baik daripada siswa dengan disposisi matematis sedang dan rendah, begitu juga dengan prestasi belajar matematika siswa dengan disposisi matematis sedang lebih baik daripada siswa dengan disposisi matematis rendah, 3 pada model pembelajaran kooperatif tipe TPS dengan pendekatan open-ended prestasi belajar matematika siswa yang memiliki disposisi matematis tinggi lebih baik daripada siswa yang memiliki disposisi matematis sedang maupun rendah. Pada pembelajaran langsung, siswa dengan disposisi matematis tinggi memiliki prestasi belajar yang lebih baik daripada siswa yang memiliki disposisi matematis sedang dan rendah, siswa dengan disposisi matematis sedang memiliki prestasi belajar yang sama dengan siswa yang memiliki disposisi matematis rendah, 4 Pada siswa

3D Printing of Molecular Models

Science.gov (United States)

Gardner, Adam; Olson, Arthur

2016-01-01

Physical molecular models have played a valuable role in our understanding of the invisible nano-scale world. We discuss 3D printing and its use in producing models of the molecules of life. Complex biomolecular models, produced from 3D printed parts, can demonstrate characteristics of molecular structure and function, such as viral self-assembly,…

THE LEARNING RESULT DIFFERENCE OF STUDENT TEACH BY USING ENHANCEMENT LEARNING MODEL OF STUDENT’S THINKING ABILITY WITH CONVENSIONAL MODEL FOR FORCE AND NEWTON LAWS MATERIAL

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Derlina .

2013-06-01

Full Text Available This research was done to observe the difference of learning achievement between student who have been teach by Enhancement Learning Model of Student’s Thinking Ability and Conventional Model. This research was done at SMP Negeri 2 Gebang. Type of this research is quasi experiment. Research population is every student of grade VIII semester 2 SMP Negeri 2 Gebang. Research sample was taken by random sampling around 2 classes as 34 students for experiment class and 34 students for control class. Learning achievement of test objective 20 of multiple choice was done as an instrument. The experiment result of pretest average is 37.94 for experiment class and 36.82 for control class. Treatment was done to each class, post test average score is 73.38 for experiment class and for student who have been teach by conventional learning is 67.05. Hypothetical testing is tcalculate > ttabe i.e 3.459 > 1.66 with significance standard α = 0.05 and dk = 66. It means that Ha was accepted, so it may conclude that there is a difference of learning achievement between Enhancement Learning Model of Student’s Thinking Ability with Conventional Learning Model for Force and Newton Laws on Grade VIII SMP Negeri 2 Gebang Annual Year 2011/2012.

HASIL BELAJAR ASPEK KETERAMPILAN IPA PADA PEMBELAJARAN LEVEL OF INQUIRY TINGKAT INQUIRY LESSON DI SMP

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Yeni Hariningsih

2016-08-01

Full Text Available Learning science in junior high school in general is focused on mastery of concepts and basic science has not yet developed abilities, such as the ability berinkuiri. Therefore, it is necessary to find the appropriate steps to improve the process of learning science. The purpose of the study iniuntuk improve learning outcomes by using the skill aspect of inquiry learning model level. The method used in this research is mixed method. The instrument used is the syllabus, lesson plans, and the observation sheet keterampilan.Teknik data collection using observation. Aspects of data analysis skills using data reduction method, coding and interpretation. Results of research conducted on 36 students showed the ability berinkuiri learners increased by using the model level of inquiry. Results of learners aspect of overall skill increases with the good category. The conclusion from this study that the use of models level of inquiry to improve the ability berinkuiri learners and improve learning outcomes aspects of science skills of learners. Pembelajaran IPA di SMP pada umumnya masih menekankan pada penguasaan konsep dan belum mengembangkan kemampuan dasar sains, seperti kemampuan berinkuiri.Oleh karena itu perlu ditemukan langkah yang tepat untuk memperbaiki proses pembelajaran IPA. Tujuan dari penelitian iniuntuk meningkatkan hasil belajar aspek keterampilan dengan menggunakan model pembelajaran level of inquiry. Metode yang digunakan dalam penelitian ini yaitu mixed methode. Instrumen yang digunakan yaitu Silabus, RPP dan lembar observasi keterampilan. Teknik pengumpulan data menggunakan observasi. Analisis data aspek keterampilan dengan menggunakan cara mereduksi data, pengkodean dan interpretasi. Hasil penelitian yang dilakukan pada 36 peserta didik menunjukkan kemampuan berinkuiri peserta didik mengalami peningkatan dengan menggunakan model level of inquiry. Hasil belajar peserta didik aspek keterampilan secara keseluruhan meningkat dengan dengan

Quantifying and Visualizing Uncertainties in Molecular Models

OpenAIRE

Rasheed, Muhibur; Clement, Nathan; Bhowmick, Abhishek; Bajaj, Chandrajit

2015-01-01

Computational molecular modeling and visualization has seen significant progress in recent years with sev- eral molecular modeling and visualization software systems in use today. Nevertheless the molecular biology community lacks techniques and tools for the rigorous analysis, quantification and visualization of the associated errors in molecular structure and its associated properties. This paper attempts at filling this vacuum with the introduction of a systematic statistical framework whe...

PROFIL REPRESENTASI SISWA SMP TERHADAP MATERI PLSV DITINJAU DARI GAYA BELAJAR KOLB

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Fariz Setyawan

2017-07-01

ABSTRACT This is a descriptive qualitative research. The aim of this study is to describe the representation profile of Linear Equation of One Variable (LEOV of Junior High School Students based on Kolb’ Learning styles: assimilator, akomodator, konverger, and diverger. The researcher conduct an interview with four SMP N 22 Surabaya students whom qualify the characteristics of Kolb’s learning styles. There are three analysis data phases: data reduction, data representation, and conclusion. Based on the result, Assimilator Subject (SA make connection between LEOV’s representation by looking for its similarity and prefer symbol representation. Akomodator Subject (SM make connection between symbol representation (S and word representation (K based on the number similarity. Converger Subject (SK make connection between representations: word (K, diagram (D and symbol (S representation based on its practical uses. Diverger Subject (SD make connection between representation based on given word and number similarities and the solution which is derived. Keywords: representation, leov, kolb’s learning styles.

HUBUNGAN POLA ASUH DENGAN POLA PERKEMBANGAN SEKSUAL SEKUNDER PADA SISWA SMP

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Uci Mayang Sari

2016-12-01

Full Text Available Background: Adolescence is a transition period from childhood to adulthood, both physically and psychologically. Parents are generally considered as primary teachers for their children, therefore parents play important roles in children development. Parenting style is one of the factors associated with the pattern of secondary sexual development. Objective: This study aimed to examine the relationship between parenting style and the pattern of secondary sexual development in junior high school students. Methods: This research was an observational analytic study, using cross sectional approach. The study population was all male students at SMP 1 Berbah Yogyakarta (188 students. Samples were selected using purposive sampling, involving 143 respondents. Data were analyzed with Chi square test. Result: There was a correlation between parenting style and the pattern of secondary sexual development (p= 0.000 <0.05, with PR value of 4,975, CI 95 % of 1,831-13,516. Conclusion: There was a relationship between parenting style and the pattern of secondary sexual development in junior high school students.

Deep Generative Models for Molecular Science

DEFF Research Database (Denmark)

Jørgensen, Peter Bjørn; Schmidt, Mikkel Nørgaard; Winther, Ole

2018-01-01

Generative deep machine learning models now rival traditional quantum-mechanical computations in predicting properties of new structures, and they come with a significantly lower computational cost, opening new avenues in computational molecular science. In the last few years, a variety of deep...... generative models have been proposed for modeling molecules, which differ in both their model structure and choice of input features. We review these recent advances within deep generative models for predicting molecular properties, with particular focus on models based on the probabilistic autoencoder (or...

UPAYA MENINGKATKAN HASIL BELAJAR PKn DENGAN METODE THINK PAIR SHARE (TPS PADA SISWA KELAS 7 D SMP NEGERI 1 JAPAH KECAMATAN JAPAH KABUPATEN BLORA SEMESTER GENAP TAHUN PELAJARAN 2012/2013

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Nani Mediatati

2013-06-01

Full Text Available Dalam pembelajaran PKn guru kelas 7 D SMP Negeri 1 Japah sering menggunakan metode ceramah yang lebih terpusat pada guru sehingga guru yang lebih aktif dan siswanya bersifat pasif. Hal ini mengakibatkan hasil belajar PKn siswa kelas 7 D SMP Negeri 1 Japah banyak yang belum mencapai KKM e”72. Dari data hasil belajar siswa dalam pembelajaran PKn materi “Sikap Positif Terhadap Perlindungan dan Penegakan Hak Asasi Manusia”(Pra siklus diketemukan 25 siswa (67,57% belum tuntas dan yang sudah tuntas sebanyak 12 siswa (32,43%. Berdasarkan data tersebut maka dilakukan tindakan perbaikan melalui Penelitian Tindakan Kelas (PTK dengan menggunakan metode Think Pair Share (TPS dalam pembelajaran PKn. Penelitian ini bertujuan untuk mendeskripsikan peningkatan hasil belajar PKn dengan menggunakan metode Think Pair Share (TPS pada siswa kelas 7 D semester 2 SMP Negeri 1 Japah Kecamatan Japah Kabupaten Blora. Penelitian ini dilakukan dalam 2 siklus dan setiap siklusnya terdiri dari 2 kali pertemuan/tatap muka. Adapun hipotesis tindakannya adalah apabila dalam pembelajaran PKn digunakan metode Think Pair Share (TPS maka diharapkan hasil belajar siswa meningkat. Indikator keberhasilan tindakan adalah 80 persen dari seluruh siswa mencapai ketuntasan belajar denganKKM e”72. Teknik pengumpulan data digunakan observasi dan tes.Teknik analisis data digunakan teknik deskriptif kualitatif dan kuantitatif. Hasil penelitian menunjukkan bahwa dengan menggunakan metode Think Pair Share (TPS dapat meningkatkan hasil belajar PKn pada siswa kelas 7 D SMP N 1 Japah. Peningkatan hasil belajar siswa terjadi pada siklus 1 dan siklus 2. Pada tahap pra siklus hanya 12 siswa (32,43% yang telah tuntas mencapai KKM, setelah dilakukan tindakan perbaikan melalui metode Think Pair Share (TPSpada siklus I hasil belajar siswa meningkat menjadi 28 siswa (75,68% yang tuntas mencapai KKM. Pada siklus II tindakan perbaikan lanjut, hasil belajar siswa meningkat lagi menjadi

Biological nitrogen and phosphorus removal in membrane bioreactors: model development and parameter estimation.

Science.gov (United States)

Cosenza, Alida; Mannina, Giorgio; Neumann, Marc B; Viviani, Gaspare; Vanrolleghem, Peter A

2013-04-01

Membrane bioreactors (MBR) are being increasingly used for wastewater treatment. Mathematical modeling of MBR systems plays a key role in order to better explain their characteristics. Several MBR models have been presented in the literature focusing on different aspects: biological models, models which include soluble microbial products (SMP), physical models able to describe the membrane fouling and integrated models which couple the SMP models with the physical models. However, only a few integrated models have been developed which take into account the relationships between membrane fouling and biological processes. With respect to biological phosphorus removal in MBR systems, due to the complexity of the process, practical use of the models is still limited. There is a vast knowledge (and consequently vast amount of data) on nutrient removal for conventional-activated sludge systems but only limited information on phosphorus removal for MBRs. Calibration of these complex integrated models still remains the main bottleneck to their employment. The paper presents an integrated mathematical model able to simultaneously describe biological phosphorus removal, SMP formation/degradation and physical processes which also include the removal of organic matter. The model has been calibrated with data collected in a UCT-MBR pilot plant, located at the Palermo wastewater treatment plant, applying a modified version of a recently developed calibration protocol. The calibrated model provides acceptable correspondence with experimental data and can be considered a useful tool for MBR design and operation.

Microbial transformation of biomacromolecules in a membrane bioreactor: implications for membrane fouling investigation.

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Zhongbo Zhou

Full Text Available BACKGROUND: The complex characteristics and unclear biological fate of biomacromolecules (BMM, including colloidal and soluble microbial products (SMP, extracellular polymeric substances (EPS and membrane surface foulants (MSF, are crucial factors that limit our understanding of membrane fouling in membrane bioreactors (MBRs. FINDINGS: In this study, the microbial transformation of BMM was investigated in a lab-scale MBR by well-controlled bioassay tests. The results of experimental measurements and mathematical modeling show that SMP, EPS, and MSF had different biodegradation behaviors and kinetic models. Based on the multi-exponential G models, SMP were mainly composed of slowly biodegradable polysaccharides (PS, proteins (PN, and non-biodegradable humic substances (HS. In contrast, EPS contained a large number of readily biodegradable PN, slowly biodegradable PS and HS. MSF were dominated by slowly biodegradable PS, which had a degradation rate constant similar to that of SMP-PS, while degradation behaviors of MSF-PN and MSF-HS were much more similar to those of EPS-PN and EPS-HS, respectively. In addition, the large-molecular weight (MW compounds (>100 kDa in BMM were found to have a faster microbial transformation rate compared to the small-MW compounds (<5 kDa. The parallel factor (PARAFAC modeling of three-dimensional fluorescence excitation-emission matrix (EEM spectra showed that the tryptophan-like PN were one of the major fractions in the BMM and they were more readily biodegradable than the HS. Besides microbial mineralization, humification and hydrolysis could be viewed as two important biotransformation mechanisms of large-MW compounds during the biodegradation process. SIGNIFICANCE: The results of this work can aid in tracking the origin of membrane foulants from the perspective of the biotransformation behaviors of SMP, EPS, and MSF.

PENGGUNAAN MEDIA AUDIO VISUAL UNTUK MENINGKATKAN HASIL BELAJAR MATERI MERODA PADA SENAM LANTAI KELAS VIII SMP NEGERI 13 SEMARANG TAHUN 2013/2014

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Sigit Budi Prastyyo

2015-01-01

Full Text Available The purpose of this study was to determine the improvement of teaching physical education in schools through the use of audio-visual media aids the learning outcomes gymnastics floor meroda the eighth grade students of SMP Negeri 13 Semarang. In this research, a classroom action research (CAR cycle , the study was conducted in two cycles of action . Methods of data collection using the methods of documentation , observation , and testing . Analysis of the data using descriptive method by way of student learning outcomes after the action . Based on the results obtained by the use of audio-visual media in the learning material meroda floor exercises can improve learning outcomes eighth grade at Junior High School 13 Semarang 2013/2014 . This is evidenced by the acquisition value of the learning outcomes of each cycle has increased . The average value of students in the first cycle the average test score of students reached 70.51 , reaching 84.72 in the second cycle . Classical completeness in the first cycle of 54.84 % and the second cycle was 90.32 % . From the research results obtained it can be concluded that the learning material meroda floor exercises with the use of audio-visual media can improve learning outcomes students of SMP Negeri 13 Semarang .

PENGARUH FASILITAS BELAJAR DAN LINGKUNGAN KELUARGA TERHADAP HASIL BELAJAR IPS TERPADU MELALUI MOTIVASI BELAJAR SMP NEGERI 1 AMBARAWA (Studi Kelas VII Tahun Ajaran 2013/2014

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Ika Maratus Sholekhah

2014-06-01

Full Text Available Tujuan Penelitian ini adalah mengetahui pengaruh fasilitas belajar dan lingkungan keluarga terhadap hasil belajar IPS Terpadu melalui motivasi belajar kelas VII SMP Negeri 1 Ambarawa. Dalam penelitian ini populasi yang digunakan adalah seluruh siswa kelas VII SMP Negeri 1 Ambarawa yang berjumlah 269 siswa. Penelitian ini menggunakan sampel yang berjumlah 81 sampel. Teknik pengambilan sampel menggunakan simple random sampling. Variabel dalam penelitian ini adalah variabel bebas yaitu fasilitas belajar (X1, lingkungan keluarga (X2, motivasi belajar (Y1 sebagai variabel interfening dan Hasil Belajar (Y2 sebagai variabel terikat. Metode pengumpulan data: observasi, dokumentasi dan angket. Metode analisis yaitu analisi deskriptif persentase. Uji asumsi klasik: normalitas, multikolinieritas, heteroskedastisitas. Sedangkan uji hipotesis: uji parsial, uji signifikansi simultan, regresi linier berganda dan koefisien determinasi. Hasil penelitian diperoleh persamaan regresi Y₁= 0,638 X₁+ 0,58 X₂+0,723+e₁ dan Y₂= 0,639 X₁+0,572 X₂+0,725+e₂. Secara deskriptif penelitian menunjukkan bahwa kategori fasilitas belajar, dan lingkungan keluarga adalah sedang. Pengaruh fasilitas belajar terhadap motivasi belajar sebesar 63,8%, lingkungan keluarga terhadap motivasi belajar sebesar 58%, pengaruhnya positif dan signifikan. Sedangkan pengaruh fasilitas belajar dan lingkungan keluarga secara bersama berpengaruh terhadap hasil belajar melalui motivasi belajar sebesar 41,9% dan sisanya sebesar 58,1% dipengaruhi oleh faktor lain yang tidak diteliti. The purpose of this study was to determine the effect of learning facilities and family environment on Integrated Social Science learning Outcomes through sudents’ motivation SMP Negeri 1 Ambarawa. The population of this study of 269 students and sample of 81 students. The population of this study was the entire seventh grade students of SMP Negeri 1 Ambarawa, amounting to 269 students. This study used a

PENERAPAN METODE DISKUSI SYNDICATE GROUP UNTUK MENINGKATKAN AKTIVITAS DAN HASIL BELAJAR PADA POKOK BAHASAN MENDESKRIPSIKAN HUBUNGAN ANTARA KELANGKAAN SUMBER DAYA DENGAN KEBUTUHAN MANUSIA YANG TIDAK TERBATAS SISWA KELAS VIII B DI SMP NEGERI 2 BANYUBIRU

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Meita Lusianti

2013-11-01

Full Text Available Aktivitas siswa dalam kegiatan belajar mengajar di SMP Negeri 2 Banyubiru belum terlihat optimal. Proses pembelajaran berpusat pada guru sehingga siswa belum terlibat langsung untuk aktif dalam pembelajaran. Kondisi tersebut mempengaruhi hasil penerimaan siswa terhadap materi pembelajaran yang berakibat rendahnya hasil ulangan harian siswa. Penelitian ini bertujuan untuk meningkatkan aktivitas dan hasil belajar siswa. Penelitian ini dilaksanakan dalam 2 (dua siklus. Kegiatan dalam setiap siklus meliputi kegiatan perencanaan, pelaksanaan, observasi, dan refleksi. Hasil penelitian diperoleh nilai rata-rata hasil belajar kognitif siswa pada siklus I sebesar 72,93 dengan ketuntasan klasikal 67%. Rata-rata hasil belajar pada siklus II sebesar 79,20 dengan ketuntasan klasikal 90%. Adapun hasil analisis aktivitas siswa pada siklus I mencapai 61% dan pada siklus II meningkat menjadi 81%. Berdasarkan hasil penelitian tersebut, dapat diambil kesimpulan bahwa penerapan metode diskusi Syndicate Group dapat peningkatan aktivitas dan hasil belajar siswa kelas VIII B SMP Negeri 2 Banyubiru tahun ajaran 2013/2014. Student activity in learning activities at SMP Negeri 2 Banyubiru seen optimum yet. Learning proces centre on teacher so the student not involve direct to active in the learning. That condition influential student outcome about learning material that come about student daily test outcome low. The research as a purpose to increase activity and student outcome learning. This research doing on two cycle. Activity in every cycle includes planning, implementation, observation, and reflection. Research result got average of cognitive learning outcome in cycle I is 72,93 with classical totally 67%. Average of learning outcome in cycle II is 79,20 with classical totally 90%. There is student activity analysis outcome on cycle I reach 61% and on cycle II rises become 81%. Grounded on research result that, be able take conclusion that implementation Syndicate

Effect of preparation conditions on properties and permeability of chitosan-sodium hexametaphosphate capsules.

Science.gov (United States)

Angelova, N; Hunkeler, D

2001-01-01

Capsules were obtained by interpolymer complexation between chitosan (polycation) and sodium hexametaphosphate (SMP, oligoanion). The effect of the preparation conditions on the capsule characteristics was evaluated. Specifically, the influence of variables such as pH, ionic strength, reagent concentration, and additives on the capsule permeability properties was investigated using dextran as a model permeant. The capsule membrane permeability was found to increase by decreasing the chitosan/SMP ratio as well as adding mannitol to the oligoanion recipient bath. Increasing the ionic strength or the pH of the initial chitosan solution was also found to enhance the membrane permeability, moving the membrane exclusion limit to higher values. Generally, the capsules prepared tinder all tested conditions had a relatively low permeability which rarely exceeded a molecular cut-off of 40 kD based on dextran standards. Furthermore, the diffusion rate showed a strong temporal dependence, indicating that the capsules prepared under various conditions exhibit different apparent pore size densities on the surface. The results indicated that, in order to obtain the desired capsule mass-transfer properties, the preparation conditions should be carefully considered and adjusted. Adding a polyol as well as low salt amount (less than 0.15%) is preferable as a means of modulating the diffusion characteristics, without disturbing the capsule mechanical stability.

The cognitive life of mechanical molecular models.

Science.gov (United States)

Charbonneau, Mathieu

2013-12-01

The use of physical models of molecular structures as research tools has been central to the development of biochemistry and molecular biology. Intriguingly, it has received little attention from scholars of science. In this paper, I argue that these physical models are not mere three-dimensional representations but that they are in fact very special research tools: they are cognitive augmentations. Despite the fact that they are external props, these models serve as cognitive tools that augment and extend the modeler's cognitive capacities and performance in molecular modeling tasks. This cognitive enhancement is obtained because of the way the modeler interacts with these models, the models' materiality contributing to the solving of the molecule's structure. Furthermore, I argue that these material models and their component parts were designed, built and used specifically to serve as cognitive facilitators and cognitive augmentations. Copyright © 2013 Elsevier Ltd. All rights reserved.

Microultrasound Molecular Imaging of Vascular Endothelial Growth Factor Receptor 2 in a Mouse Model of Tumor Angiogenesis

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Joshua J. Rychak

2007-09-01

Full Text Available High-frequency microultrasound imaging of tumor progression in mice enables noninvasive anatomic and functional imaging at excellent spatial and temporal resolution, although microultrasonography alone does not offer molecular scale data. In the current study, we investigated the use of microbubble ultrasound contrast agents bearing targeting ligands specific for molecular markers of tumor angiogenesis using high-frequency microultrasound imaging. A xenograft tumor model in the mouse was used to image vascular endothelial growth factor receptor 2 (VEGFR-2 expression with microbubbles conjugated to an anti-VEGFR-2 monoclonal antibody or an isotype control. Microultrasound imaging was accomplished at a center frequency of 40 MHz, which provided lateral and axial resolutions of 40 and 90 μm, respectively. The B-mode (two-dimensional mode acoustic signal from microbubbles bound to the molecular target was determined by an ultrasound-based destruction-subtraction scheme. Quantification of the adherent microbubble fraction in nine tumor-bearing mice revealed significant retention of VEGFR-2-targeted microbubbles relative to control-targeted microbubbles. These data demonstrate that contrast-enhanced microultrasound imaging is a useful method for assessing molecular expression of tumor angiogenesis in mice at high resolution.

KESANTUNAN BERBAHASA DALAM INTERAKSI PEMBELAJARAN BAHASA JAWA DI SMP N 1 BANYUMAS

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Astiana Ajeng Rahadini

2014-10-01

Full Text Available Penelitian ini bertujuan untuk mendeskripsikan dan menganalisis bentuk, nilai, dan fungsi kesantunan berbahasa Jawa dalam interaksi antara guru dan siswa ketika pembelajaran bahasa Jawa di SMP N 1 Banyumas serta implikasinya bagi pembelajaran. Jenis pendekatan yang digunakan, yaitu deskriptif. Metode pengumpula data yang digunakan, yaitu metode simak bebas libat cakap, teknik rekam, dan catat. Hasil penelitian menunjukkan: (1 bentuk kesantunan berbahasa Jawa direpresentasi-kan dalam modus deklaratif atau kalimat berita, modus interogatif atau kalimat pertanyaan, modus imperatif atau kalimat perintah yang merepresentasikan jenis tindak tutur representatif, direktif, ekspresif, dan komisif; (2 Nilai kesantunan berbahasa dilihat dari isi tuturan yang mematuhi prinsip kesantunan berbahasa Jawa dan penggunaan unggah-ungguh basa; (3 Fungsi kesantunan berbahasa meliputi fungsi kompetitif dan fungsi menyenangkan. (4 Implikasi hasil penelitian meliputi peng-gunaan bentuk-bentuk kesantunan berbahasa Jawa untuk menyamankan interaksi pembelajaran, peningkatan nilai kesantunan tuturan dengan memperhatikan isi tuturan dan penggunaan unggah-ungguh basa yang benar, dan penggunaan fungsi kesantunan menyenangkan dan ungkapan penanda kesantunan untuk tindak tutur direktif dan ekspresif. Kata kunci: kesantunan berbahasa Jawa, interaksi pembelajaran

Medulloblastoma: Molecular Genetics and Animal Models

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Corey Raffel

2004-07-01

Full Text Available Medulloblastoma is a primary brain tumor found in the cerebellum of children. The tumor occurs in association with two inherited cancer syndromes: Turcot syndrome and Gorlin syndrome. Insights into the molecular biology of the tumor have come from looking at alterations in the genes altered in these syndromes, PTC and APC, respectively. Murine models of medulloblastoma have been constructed based on these alterations. Additional murine models that, while mimicking the appearance of the human tumor, seem unrelated to the human tumor's molecular alterations have been made. In this review, the clinical picture, origin, molecular biology, murine models of medulloblastoma are discussed. Although a great deal has been discovered about this tumor, the genetic alterations responsible for tumor development in a majority of patients have yet to be described.

A n-vector model for charge transport in molecular semiconductors.

Science.gov (United States)

Jackson, Nicholas E; Kohlstedt, Kevin L; Chen, Lin X; Ratner, Mark A

2016-11-28

We develop a lattice model utilizing coarse-grained molecular sites to study charge transport in molecular semiconducting materials. The model bridges atomistic descriptions and structureless lattice models by mapping molecular structure onto sets of spatial vectors isomorphic with spin vectors in a classical n-vector Heisenberg model. Specifically, this model incorporates molecular topology-dependent orientational and intermolecular coupling preferences, including the direct inclusion of spatially correlated transfer integrals and site energy disorder. This model contains the essential physics required to explicitly simulate the interplay of molecular topology and correlated structural disorder, and their effect on charge transport. As a demonstration of its utility, we apply this model to analyze the effects of long-range orientational correlations, molecular topology, and intermolecular interaction strength on charge motion in bulk molecular semiconductors.

EFFECT OF INFORMATION SERVICES USING THE MEDIA FILM TO SELF-CONFIDENCE STUDENT OF CLASS VIII SMP NEGERI 8 METRO

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MUDAIM MUDAIM

2015-06-01

Full Text Available Abstract: Pessimism and attitudes that consider themselves weak and does not have the ability when facing a problem will make individual impediment in the task of development. Problems confidence that underlies the research are: a Students are less confident in the ability it has, b Students feel pessimistic when faced with an issue, c Student perception subjectively, d Students still do not do the work independently, and e negative minded students with a state-owned. The problems of this study are whether there is an influence of information services using the medium of film to the confidence of eighth-grade students of SMP Negeri 8 Metro. The purpose of this study was to determine whether there is an influence of information services using the medium of film to the self-confidence of students in class VIII SMP Negeri 8 Metro. Subject participant is graders VIII-E total 30 students. Data were collected by questionnaire self-confidence and analyzed the data used is the t-test. The results of this study, shown by the difference in change scores of confidence from the pre-test and post-test of 17.1. Testing the hypothesis obtained calculation results thitung6,036> table = 1.699. The conclusion is that the information services implemented using the film medium can be a positive influence on self-esteem, especially students of class VIII. The advice given is to use the medium of film should be done intensively and more creative by BK teachers in giving information service. Keywords: Confidence, Service Information Using Media Film.

Reliability analysis of nuclear component cooling water system using semi-Markov process model

International Nuclear Information System (INIS)

Veeramany, Arun; Pandey, Mahesh D.

2011-01-01

Research highlights: → Semi-Markov process (SMP) model is used to evaluate system failure probability of the nuclear component cooling water (NCCW) system. → SMP is used because it can solve reliability block diagram with a mixture of redundant repairable and non-repairable components. → The primary objective is to demonstrate that SMP can consider Weibull failure time distribution for components while a Markov model cannot → Result: the variability in component failure time is directly proportional to the NCCW system failure probability. → The result can be utilized as an initiating event probability in probabilistic safety assessment projects. - Abstract: A reliability analysis of nuclear component cooling water (NCCW) system is carried out. Semi-Markov process model is used in the analysis because it has potential to solve a reliability block diagram with a mixture of repairable and non-repairable components. With Markov models it is only possible to assume an exponential profile for component failure times. An advantage of the proposed model is the ability to assume Weibull distribution for the failure time of components. In an attempt to reduce the number of states in the model, it is shown that usage of poly-Weibull distribution arises. The objective of the paper is to determine system failure probability under these assumptions. Monte Carlo simulation is used to validate the model result. This result can be utilized as an initiating event probability in probabilistic safety assessment projects.

NOS-mediated morphological and molecular modifications in rats infused with Aβ (1-40), as a model of Alzheimer's disease, in response to a new lipophilic molecular combination codrug-1.

Science.gov (United States)

Zara, Susi; Di Stefano, Antonio; Nasuti, Cinzia; Rapino, Monica; Patruno, Antonia; Pesce, Mirko; Sozio, Piera; Cerasa, Laura S; Cataldi, Amelia

2011-04-01

Alzheimer's disease is a neurodegenerative pathology due to the presence of β-amyloid plaques at brain level and hippocampus level and associated with the loss of memory speech and learning. At the basis of these effects lie molecular mechanisms which include nitric oxide metabolic pathway, whose involvement in the occurrence of morphological modifications related to such neurodegenerative process is suggested. Current evidences show that the non-steroidal anti-inflammatory drug ibuprofen posses a protective effect against the development of the disease, substantially delaying its onset; furthermore (R)-α-lipoic acid seems to have an antioxidant ameliorating effect on disease progression. Starting from these data, a new lipophilic codrug 1, obtained by joining an antioxidant molecule with an NSAID, has been previously synthesized. Our aim has been to investigate the possible therapeutical effects of codrug 1, compared to ibuprofen, on the molecular events at the basis of behavioural and morphological modifications occurring in Aβ (1-40) infused rat brains. Ibuprofen and codrug 1 seem to protect the subject against memory performance impairment and against behavioural detriment, induced by administration of Aβ (1-40) peptide. Such evidences are supported by morphological and biochemical findings showing Aβ (1-40) to determine cell disorganization, increased number of β-amyloid plaques and capillary vessels dilatation in parallel to increased total and specific NOS activity and to apoptosis occurrence, partly prevented by ibuprofen, more broadly by codrug 1. Such results underline the involvement of nitric oxide metabolic pathway in the events related to the onset of this pathology and suggest codrug 1 as a useful tool to protect the brain against cognitive and behavioural dysfunction, by reducing β-amyloid plaques formation and by inhibiting NOS signalling pathway and apoptosis occurrence. Copyright © 2010 Elsevier Inc. All rights reserved.

PENERAPAN STANDAR PELAYANAN MINIMAL PEGAWAI TATA USAHA DI SMP NEGERI SE-KOTA SALATIGA

Directory of Open Access Journals (Sweden)

Aan Ikhsananto

2016-06-01

Full Text Available Pegawai tata usaha memiliki tugas-tugas pelayanan yang berhubungan dengan banyak orang di lingkungan sekolah. Observasi awal yang dilakukan peneliti menunjukkan bahwa penerapan Standar Pelayanan Minimal (SPM masih kurang. Melalui peningkatan kompetensi pegawai diharapkan dapat memenuhi standar pelayanan minimal pegawai tata usaha di sekolah. Pemanfaatan fasilitas kantor juga diharapkan dapat menunjang standar pelayanan minimal. Selain itu ketersediaan teknologi informasi diharapkan penerapan standar pelayanan minimal dapat semakin meningkat. Tujuan dari penelitian ini adalah untuk mengetahui apakah kompetensi pegawai, fasilitas kantor, dan teknologi infomasi berpengaruh terhadap penerapan SPM pegawai tata usaha.Variabel dalam penelitian ini adalah kompetensi pegawai (X1, fasilitas kantor (X2 dan teknologi informasi (X3 sebagai variabel bebas serta standar pelayanan minimal (Y sebagai variabel terikatnya. Sampel dalam penelitian ini adalah seluruh pegawai tata usaha (TU di SMP Negeri Se-Kota Salatiga, berjumlah 54 pegawai. Metode pengumpulan data yang digunakan adalah metode dokumentasi, wawancara, dan kuesioner. Teknik analisis data dapat menggunakan regresi berganda bantuan SPSS, asumsi klasik, dan analisis deskriptif persentase. Hasil penelitian ini dapat disimpulkan bahwa kompetensi pegawai, fasilitas kantor, dan teknologi informasi berpengaruh positif dan signifikan terhadap penerapan standar pelayanan minimal pegawai. Clerical employee has service tasks associated with many people in the school environment. Preliminary observations conducted by researchers showed that the application of the Minimum Service Standards (SPM is still lacking. By improving the competence of employees is expected to meet minimum service standards in school administration employees. The usefullness of office facilities are also expected to support the minimum service standards. Besides the availability of information technology is expected implementation of

Genome-wide investigation and expression analyses of WD40 protein family in the model plant foxtail millet (Setaria italica L..

Directory of Open Access Journals (Sweden)

Awdhesh Kumar Mishra

Full Text Available WD40 proteins play a crucial role in diverse protein-protein interactions by acting as scaffolding molecules and thus assisting in the proper activity of proteins. Hence, systematic characterization and expression profiling of these WD40 genes in foxtail millet would enable us to understand the networks of WD40 proteins and their biological processes and gene functions. In the present study, a genome-wide survey was conducted and 225 potential WD40 genes were identified. Phylogenetic analysis categorized the WD40 proteins into 5 distinct sub-families (I-V. Gene Ontology annotation revealed the biological roles of the WD40 proteins along with its cellular components and molecular functions. In silico comparative mapping with sorghum, maize and rice demonstrated the orthologous relationships and chromosomal rearrangements including duplication, inversion and deletion of WD40 genes. Estimation of synonymous and non-synonymous substitution rates revealed its evolutionary significance in terms of gene-duplication and divergence. Expression profiling against abiotic stresses provided novel insights into specific and/or overlapping expression patterns of SiWD40 genes. Homology modeling enabled three-dimensional structure prediction was performed to understand the molecular functions of WD40 proteins. Although, recent findings had shown the importance of WD40 domains in acting as hubs for cellular networks during many biological processes, it has invited a lesser research attention unlike other common domains. Being a most promiscuous interactors, WD40 domains are versatile in mediating critical cellular functions and hence this genome-wide study especially in the model crop foxtail millet would serve as a blue-print for functional characterization of WD40s in millets and bioenergy grass species. In addition, the present analyses would also assist the research community in choosing the candidate WD40s for comprehensive studies towards crop improvement

Genome-wide investigation and expression analyses of WD40 protein family in the model plant foxtail millet (Setaria italica L.).

Science.gov (United States)

Mishra, Awdhesh Kumar; Muthamilarasan, Mehanathan; Khan, Yusuf; Parida, Swarup Kumar; Prasad, Manoj

2014-01-01

WD40 proteins play a crucial role in diverse protein-protein interactions by acting as scaffolding molecules and thus assisting in the proper activity of proteins. Hence, systematic characterization and expression profiling of these WD40 genes in foxtail millet would enable us to understand the networks of WD40 proteins and their biological processes and gene functions. In the present study, a genome-wide survey was conducted and 225 potential WD40 genes were identified. Phylogenetic analysis categorized the WD40 proteins into 5 distinct sub-families (I-V). Gene Ontology annotation revealed the biological roles of the WD40 proteins along with its cellular components and molecular functions. In silico comparative mapping with sorghum, maize and rice demonstrated the orthologous relationships and chromosomal rearrangements including duplication, inversion and deletion of WD40 genes. Estimation of synonymous and non-synonymous substitution rates revealed its evolutionary significance in terms of gene-duplication and divergence. Expression profiling against abiotic stresses provided novel insights into specific and/or overlapping expression patterns of SiWD40 genes. Homology modeling enabled three-dimensional structure prediction was performed to understand the molecular functions of WD40 proteins. Although, recent findings had shown the importance of WD40 domains in acting as hubs for cellular networks during many biological processes, it has invited a lesser research attention unlike other common domains. Being a most promiscuous interactors, WD40 domains are versatile in mediating critical cellular functions and hence this genome-wide study especially in the model crop foxtail millet would serve as a blue-print for functional characterization of WD40s in millets and bioenergy grass species. In addition, the present analyses would also assist the research community in choosing the candidate WD40s for comprehensive studies towards crop improvement of millets and

The Development of Geometri Teaching Materials Based on Constructivism to Improve the Students' Mathematic Reasoning Ability through Cooperative Learing Jigsaw at the Class VIII of SMP Negeri 3 Padangsidimpuan

Science.gov (United States)

Dewi, Izwita; Harahap, Muhammad Syahri

2016-01-01

The purposes of this research were to know the validity, practicality, and effectivity of geometrical learning material based on the constructivism to Increase students' mathematic reasoning ability and increasing students' mathematic reasoning ability by using learning material at the grade VIII of SMP Negeri 3 Padangsidimpuan. Type of the…

Molecular modeling and multiscaling issues for electronic material applications

CERN Document Server

Iwamoto, Nancy; Yuen, Matthew; Fan, Haibo

Volume 1 : Molecular Modeling and Multiscaling Issues for Electronic Material Applications provides a snapshot on the progression of molecular modeling in the electronics industry and how molecular modeling is currently being used to understand material performance to solve relevant issues in this field. This book is intended to introduce the reader to the evolving role of molecular modeling, especially seen through the eyes of the IEEE community involved in material modeling for electronic applications.  Part I presents  the role that quantum mechanics can play in performance prediction, such as properties dependent upon electronic structure, but also shows examples how molecular models may be used in performance diagnostics, especially when chemistry is part of the performance issue.  Part II gives examples of large-scale atomistic methods in material failure and shows several examples of transitioning between grain boundary simulations (on the atomistic level)and large-scale models including an example ...

Exploring the common molecular basis for the universal DNA mutation bias: Revival of Loewdin mutation model

International Nuclear Information System (INIS)

Fu, Liang-Yu; Wang, Guang-Zhong; Ma, Bin-Guang; Zhang, Hong-Yu

2011-01-01

Highlights: → There exists a universal G:C → A:T mutation bias in three domains of life. → This universal mutation bias has not been sufficiently explained. → A DNA mutation model proposed by Loewdin 40 years ago offers a common explanation. -- Abstract: Recently, numerous genome analyses revealed the existence of a universal G:C → A:T mutation bias in bacteria, fungi, plants and animals. To explore the molecular basis for this mutation bias, we examined the three well-known DNA mutation models, i.e., oxidative damage model, UV-radiation damage model and CpG hypermutation model. It was revealed that these models cannot provide a sufficient explanation to the universal mutation bias. Therefore, we resorted to a DNA mutation model proposed by Loewdin 40 years ago, which was based on inter-base double proton transfers (DPT). Since DPT is a fundamental and spontaneous chemical process and occurs much more frequently within GC pairs than AT pairs, Loewdin model offers a common explanation for the observed universal mutation bias and thus has broad biological implications.

PENGARUH PENGGUNAAN MODEL COOPERATIVE LEARNING TIPE GROUP INVESTIGATION (GI TERHADAP HASIL BELAJAR IPS TERPADU KELAS VIII SEMESTER GENAP SMPYPI 1 BANDAR MATARAM LAMPUNG TENGAH T.P 2015/2016

Directory of Open Access Journals (Sweden)

Desi Fatmawati Maryatun

2016-05-01

Full Text Available Metode cooperative learning tipe group investigation merupakan model pembelajaran kooperatif yang dapat melibatkan peserta didik secara aktif dalam kegiatan pembelajaran mulai dari merencanakan topik-topik yang akan dipelajari, bagaimana melaksanakan investigasinya, hingga melakukan presentasi kelompok dan evaluasi. Tujuan penelitian ini adalah untuk mengetahui adanya pengaruh penggunaan model pembelajaran cooperative learning tipe Group Investigation terhadap hasil belajar IPS Terpadu peserta didik kelas VIII semester genap SMP YPI 1 Bandar Mataram  Lampung Tengah tahun pelajaran 2015/2016. Hipotesis yang penulis ajukan adalah “Ada pengaruh yang positif pada model pembelajaran cooperative learning tipe Group Investigation terhadap hasil belajar IPS Terpadu peserta didik kelas VIII semester genap SMP YPI 1 Bandar Mataram  Lampung Tengah tahun pelajaran 2015/2016. Populasi dalam penelitian ini adalah siswa kelas VIII SMP YPI 1 Bandar Mataram Lampung Tengah Tahun Pelajaran 2015/2016 yaitu berjumlah 48 orang siswa dan diantaranya terdiri dari 2 kelas. Dan yang menjadi sampel dalam penelitian ini adalah kelas VIIIa dan VIIIb. Kelas VIIIa sebagai kelas eksperimen dan kelas VIIIb sebagai kelas control, sampel diambil menggunakan teknik purposive sampling, Eksperimen dilaksanakan pada siswa kelas VIIIa Semester Genap SMP YPI 1 Bandar Mataram Lampung Tengah Tahun Pelajaran 2015/2016 yang berjumlah 24 peserta didik. Data penelitian ini dikumpulkan dengan menggunakan  metode observasi, wawancara, dokumentasi, dan tes. Sedangkan untuk mengetahui tingkat validitas dan reliabilitas penulis menggunakan rumus K-R 20. Kemudian untuk menguji/membuktikan hipotesis digunakan rumus Regresi Linier Sederhana yaitu  Ŷ = a + bx. Nilai Ŷ = 73,33+ 0,5 X yang dilanjutkan dengan rumus thitung > ttabel.pada daftar signifikan 5% yaitu 4 > 1,72  dan pada taraf signifikan 1% yaitu 4 > 2,52. Dengan demikian hipotesisnya diterima karena ada pengaruh yang positif

OSCAR API for Real-Time Low-Power Multicores and Its Performance on Multicores and SMP Servers

Science.gov (United States)

Kimura, Keiji; Mase, Masayoshi; Mikami, Hiroki; Miyamoto, Takamichi; Shirako, Jun; Kasahara, Hironori

OSCAR (Optimally Scheduled Advanced Multiprocessor) API has been designed for real-time embedded low-power multicores to generate parallel programs for various multicores from different vendors by using the OSCAR parallelizing compiler. The OSCAR API has been developed by Waseda University in collaboration with Fujitsu Laboratory, Hitachi, NEC, Panasonic, Renesas Technology, and Toshiba in an METI/NEDO project entitled "Multicore Technology for Realtime Consumer Electronics." By using the OSCAR API as an interface between the OSCAR compiler and backend compilers, the OSCAR compiler enables hierarchical multigrain parallel processing with memory optimization under capacity restriction for cache memory, local memory, distributed shared memory, and on-chip/off-chip shared memory; data transfer using a DMA controller; and power reduction control using DVFS (Dynamic Voltage and Frequency Scaling), clock gating, and power gating for various embedded multicores. In addition, a parallelized program automatically generated by the OSCAR compiler with OSCAR API can be compiled by the ordinary OpenMP compilers since the OSCAR API is designed on a subset of the OpenMP. This paper describes the OSCAR API and its compatibility with the OSCAR compiler by showing code examples. Performance evaluations of the OSCAR compiler and the OSCAR API are carried out using an IBM Power5+ workstation, an IBM Power6 high-end SMP server, and a newly developed consumer electronics multicore chip RP2 by Renesas, Hitachi and Waseda. From the results of scalability evaluation, it is found that on an average, the OSCAR compiler with the OSCAR API can exploit 5.8 times speedup over the sequential execution on the Power5+ workstation with eight cores and 2.9 times speedup on RP2 with four cores, respectively. In addition, the OSCAR compiler can accelerate an IBM XL Fortran compiler up to 3.3 times on the Power6 SMP server. Due to low-power optimization on RP2, the OSCAR compiler with the OSCAR API

Pengaruh Penggunaan Pembelajaran Kontekstual dengan Teknik SQ4R terhadap Peningkatan Kemampuan Pemahaman dan Berpikir Kritis Matematis Siswa SMP Negeri 8 Kota Tasikmalaya

OpenAIRE

Rustina, Ratna

2014-01-01

This pre-post randomly control group experimental study aimed at investigating the effect of Contextual Learning with SQ4R on the improvement of students mathematical understanding and critical thinking. The population of this study was all grade VIII students in SMP Negeri 8 Tasikmalaya while the randomly selected sample was two classes. One class was assigned as experimental group, treated through Contextual Learning with SQR4, and the other class as control group treated through conventi...

Molecular models of zinc phthalocyanines: semi-empirical molecular orbital computations and physicochemical properties studied by molecular mechanics simulations

International Nuclear Information System (INIS)

Gantchev, Tsvetan G.; van Lier, Johan E.; Hunting, Darel J.

2005-01-01

To build 3D-molecular models of Zinc-phthalocyanines (ZnPc) and to study their diverse chemical and photosensitization properties, we performed quantum mechanical molecular orbital (MO) semi-empirical (AM1) computations of the ground, excited singlet and triplet states as well as free radical (ionic) species. RHF and UHF (open shell) geometry optimizations led to near-perfect symmetrical ZnPc. Predicted ionization potentials (IP), electron affinities (EA) and lowest electronic transitions of ZnPc are in good agreement with the published experimental and theoretical data. The computation-derived D 4h /D 2h -symmetry 3D-structures of ground and excited states and free radicals of ZnPc, together with the frontier orbital energies and Mulliken electron population analysis enabled us to build robust molecular models. These models were used to predict important chemical-reactivity entities such as global electronegativity (χ), hardness (η) and local softness based on Fukui-functions analysis. Examples of molecular mechanics (MM) applications of the 3D-molecular models are presented as approaches to evaluate solvation free energy (ΔG 0 ) solv and to estimate ground- and excited- state oxidation/reduction potentials as well as intermolecular interactions and stability of ground and excited state dimers (exciplexes) and radical ion-pairs

Molecular modeling: An open invitation for applied mathematics

Science.gov (United States)

Mezey, Paul G.

2013-10-01

Molecular modeling methods provide a very wide range of challenges for innovative mathematical and computational techniques, where often high dimensionality, large sets of data, and complicated interrelations imply a multitude of iterative approximations. The physical and chemical basis of these methodologies involves quantum mechanics with several non-intuitive aspects, where classical interpretation and classical analogies are often misleading or outright wrong. Hence, instead of the everyday, common sense approaches which work so well in engineering, in molecular modeling one often needs to rely on rather abstract mathematical constraints and conditions, again emphasizing the high level of reliance on applied mathematics. Yet, the interdisciplinary aspects of the field of molecular modeling also generates some inertia and perhaps too conservative reliance on tried and tested methodologies, that is at least partially caused by the less than up-to-date involvement in the newest developments in applied mathematics. It is expected that as more applied mathematicians take up the challenge of employing the latest advances of their field in molecular modeling, important breakthroughs may follow. In this presentation some of the current challenges of molecular modeling are discussed.

Multi-level molecular modelling for plasma medicine

International Nuclear Information System (INIS)

Bogaerts, Annemie; Khosravian, Narjes; Van der Paal, Jonas; Verlackt, Christof C W; Yusupov, Maksudbek; Kamaraj, Balu; Neyts, Erik C

2016-01-01

Modelling at the molecular or atomic scale can be very useful for obtaining a better insight in plasma medicine. This paper gives an overview of different atomic/molecular scale modelling approaches that can be used to study the direct interaction of plasma species with biomolecules or the consequences of these interactions for the biomolecules on a somewhat longer time-scale. These approaches include density functional theory (DFT), density functional based tight binding (DFTB), classical reactive and non-reactive molecular dynamics (MD) and united-atom or coarse-grained MD, as well as hybrid quantum mechanics/molecular mechanics (QM/MM) methods. Specific examples will be given for three important types of biomolecules, present in human cells, i.e. proteins, DNA and phospholipids found in the cell membrane. The results show that each of these modelling approaches has its specific strengths and limitations, and is particularly useful for certain applications. A multi-level approach is therefore most suitable for obtaining a global picture of the plasma–biomolecule interactions. (paper)

PELATIHAN BETTER TEACHER AND LEARNING BAGI GURU IPS SMP DAN MTS SWASTA DI KECAMATAN GENUK KOTA SEMARANG

Directory of Open Access Journals (Sweden)

Eko Handoyo

2011-04-01

Full Text Available Tujuan kegiatan ini adalah a meningkatkan keterampilan guru dalam memetakan kurikulum, b meningkatkan keterampilan guru dalam menyusun lembar kerja, c meningkatkan keterampilan guru dalam memanfaatkan media pembelajaran, d meningkatkan keterampilan guru dalam menyusun rubrik penilaian, dan e meningkatkan keterampilan guru dalam menyusun jurnal refleksi. Pelatihan Better Teacher and Learning Bagi Guru Mata Pelajaran IPS SMP dan MTs Swasta di Kecamatan Genuk Kota Semarang mempunyai manfaat bagi guru dalam melaksanakan pembelajaran yang berkualitas. Melalui kegiatan tersebut, guru dapat memdapatkan manfaat berupa peningkatan keterampilan dalam memetakan kurikulum, peningkatan keterampilan dalam menyusun lembar kerja, peningkatan keterampilan dalam memanfaatkan media pembelajaran, peningkatan keterampilan dalam menyusun rubrik penilaian, dan peningkatan keterampilan dalam menyusun jurnal refleksi. Kata Kunci: Pengajaran Profesional, Pembelajaran Bermakna, Better Teacher and Learning

Performance Modeling and Optimization of a High Energy CollidingBeam Simulation Code

Energy Technology Data Exchange (ETDEWEB)

Shan, Hongzhang; Strohmaier, Erich; Qiang, Ji; Bailey, David H.; Yelick, Kathy

2006-06-01

An accurate modeling of the beam-beam interaction is essential to maximizing the luminosity in existing and future colliders. BeamBeam3D was the first parallel code that can be used to study this interaction fully self-consistently on high-performance computing platforms. Various all-to-all personalized communication (AAPC) algorithms dominate its communication patterns, for which we developed a sequence of performance models using a series of micro-benchmarks. We find that for SMP based systems the most important performance constraint is node-adapter contention, while for 3D-Torus topologies good performance models are not possible without considering link contention. The best average model prediction error is very low on SMP based systems with of 3% to 7%. On torus based systems errors of 29% are higher but optimized performance can again be predicted within 8% in some cases. These excellent results across five different systems indicate that this methodology for performance modeling can be applied to a large class of algorithms.

Performance Modeling and Optimization of a High Energy Colliding Beam Simulation Code

International Nuclear Information System (INIS)

Shan, Hongzhang; Strohmaier, Erich; Qiang, Ji; Bailey, David H.; Yelick, Kathy

2006-01-01

An accurate modeling of the beam-beam interaction is essential to maximizing the luminosity in existing and future colliders. BeamBeam3D was the first parallel code that can be used to study this interaction fully self-consistently on high-performance computing platforms. Various all-to-all personalized communication (AAPC) algorithms dominate its communication patterns, for which we developed a sequence of performance models using a series of micro-benchmarks. We find that for SMP based systems the most important performance constraint is node-adapter contention, while for 3D-Torus topologies good performance models are not possible without considering link contention. The best average model prediction error is very low on SMP based systems with of 3% to 7%. On torus based systems errors of 29% are higher but optimized performance can again be predicted within 8% in some cases. These excellent results across five different systems indicate that this methodology for performance modeling can be applied to a large class of algorithms

Integrated multiscale modeling of molecular computing devices

International Nuclear Information System (INIS)

Cummings, Peter T; Leng Yongsheng

2005-01-01

Molecular electronics, in which single organic molecules are designed to perform the functions of transistors, diodes, switches and other circuit elements used in current siliconbased microelecronics, is drawing wide interest as a potential replacement technology for conventional silicon-based lithographically etched microelectronic devices. In addition to their nanoscopic scale, the additional advantage of molecular electronics devices compared to silicon-based lithographically etched devices is the promise of being able to produce them cheaply on an industrial scale using wet chemistry methods (i.e., self-assembly from solution). The design of molecular electronics devices, and the processes to make them on an industrial scale, will require a thorough theoretical understanding of the molecular and higher level processes involved. Hence, the development of modeling techniques for molecular electronics devices is a high priority from both a basic science point of view (to understand the experimental studies in this field) and from an applied nanotechnology (manufacturing) point of view. Modeling molecular electronics devices requires computational methods at all length scales - electronic structure methods for calculating electron transport through organic molecules bonded to inorganic surfaces, molecular simulation methods for determining the structure of self-assembled films of organic molecules on inorganic surfaces, mesoscale methods to understand and predict the formation of mesoscale patterns on surfaces (including interconnect architecture), and macroscopic scale methods (including finite element methods) for simulating the behavior of molecular electronic circuit elements in a larger integrated device. Here we describe a large Department of Energy project involving six universities and one national laboratory aimed at developing integrated multiscale methods for modeling molecular electronics devices. The project is funded equally by the Office of Basic

Pengaruh model pembelajaran, gaya kognitif dan kemampuan awal terhadap hasil belajar matematika Siswa SMPN 1 Rantepao

Directory of Open Access Journals (Sweden)

Sonny Yalti Duma

2017-04-01

Full Text Available This research is experimental research that aims to determine whether the model of learning, cognitive style and ability to influence the outcome of learning early math class VIII SMP Negeri 1 Rantepao. Population in this research is class VIII SMP Negeri 1Rantepao. The instrument used in this study was the observation sheets, questionnaires, mathematics achievement test that includes pre-test and post-test, test early and test the ability of cognitive style (Test GEFT. The data obtained were analyzed using descriptive statistics and inferential statistical analysis using linear regression with interaction factors. The results showed that students' mathematics learning outcomes are influenced by a model of learning, cognitive styles and abilities early.

Investigations of shot reproducibility for the SMP diode at 4.5 MV.

Energy Technology Data Exchange (ETDEWEB)

Bennett, Nichelle [National Security Technologies, LLC, Las Vegas, NV (United States); Crain, Marlon D. [National Security Technologies, LLC, Las Vegas, NV (United States); Droemer, Darryl W. [National Security Technologies, LLC, Las Vegas, NV (United States); Gignac, Raymond Edward [National Security Technologies, LLC, Las Vegas, NV (United States); Lare, Gregory A. [National Security Technologies, LLC, Las Vegas, NV (United States); Molina, Isidro [National Security Technologies, LLC, Las Vegas, NV (United States); Obregon, Rafael [National Security Technologies, LLC, Las Vegas, NV (United States); Smith, Chase C. [National Security Technologies, LLC, Las Vegas, NV (United States); Wilkins, Frank Lee [National Security Technologies, LLC, Las Vegas, NV (United States); Welch, Dale Robert [Voss Scientific, LLC, Albuquerque, NM (United States); Cordova, Steve Ray; Gallegos, M.; Johnston, Mark D.; Kiefer, Mark Linden; Leckbee, Joshua J.; Nielsen, Daniel Scott; Oliver, Bryan Velten; Renk, Timothy Jerome; Romero, Tobias; Webb, Timothy Jay; Ziska, Derek Raymond

2013-11-01

In experiments conducted on the RITS-6 accelerator, the SMP diode exhibits sig- ni cant shot-to-shot variability. Speci cally, for identical hardware operated at the same voltage, some shots exhibit a catastrophic drop in diode impedance. A study is underway to identify sources of shot-to-shot variations which correlate with diode impedance collapse. To remove knob emission as a source, only data from a shot series conducted with a 4.5-MV peak voltage are considered. The scope of this report is limited to sources of variability which occur away from the diode, such as power ow emission and trajectory changes, variations in pulsed power, dustbin and transmission line alignment, and di erent knob shapes. We nd no changes in the transmission line hardware, alignment, or hardware preparation methods which correlate with impedance collapse. However, in classifying good versus poor shots, we nd that there is not a continuous spectrum of diode impedance behavior but that the good and poor shots can be grouped into two distinct impedance pro les. This result forms the basis of a follow-on study focusing on the variability resulting from diode physics. 3

Pharmacophore modeling, virtual screening and molecular docking of ATPase inhibitors of HSP70.

Science.gov (United States)

Sangeetha, K; Sasikala, R P; Meena, K S

2017-10-01

Heat shock protein 70 is an effective anticancer target as it influences many signaling pathways. Hence the study investigated the important pharmacophore feature required for ATPase inhibitors of HSP70 by generating a ligand based pharmacophore model followed by virtual based screening and subsequent validation by molecular docking in Discovery studio V4.0. The most extrapolative pharmacophore model (hypotheses 8) consisted of four hydrogen bond acceptors. Further validation by external test set prediction identified 200 hits from Mini Maybridge, Drug Diverse, SCPDB compounds and Phytochemicals. Consequently, the screened compounds were refined by rule of five, ADMET and molecular docking to retain the best competitive hits. Finally Phytochemical compounds Muricatetrocin B, Diacetylphiladelphicalactone C, Eleutheroside B and 5-(3-{[1-(benzylsulfonyl)piperidin-4-yl]amino}phenyl)- 4-bromo-3-(carboxymethoxy)thiophene-2-carboxylic acid were obtained as leads to inhibit the ATPase activity of HSP70 in our findings and thus can be proposed for further in vitro and in vivo evaluation. Copyright © 2017 Elsevier Ltd. All rights reserved.

Limiting assumptions in molecular modeling: electrostatics.

Science.gov (United States)

Marshall, Garland R

2013-02-01

Molecular mechanics attempts to represent intermolecular interactions in terms of classical physics. Initial efforts assumed a point charge located at the atom center and coulombic interactions. It is been recognized over multiple decades that simply representing electrostatics with a charge on each atom failed to reproduce the electrostatic potential surrounding a molecule as estimated by quantum mechanics. Molecular orbitals are not spherically symmetrical, an implicit assumption of monopole electrostatics. This perspective reviews recent evidence that requires use of multipole electrostatics and polarizability in molecular modeling.

Molecular clouds and galactic spiral structure

International Nuclear Information System (INIS)

Dame, T.M.

1984-02-01

Galactic CO line emission at 115 GHz was surveyed in order to study the distribution of molecular clouds in the inner galaxy. Comparison of this survey with similar H1 data reveals a detailed correlation with the most intense 21 cm features. To each of the classical 21 cm H1 spiral arms of the inner galaxy there corresponds a CO molecular arm which is generally more clearly defined and of higher contrast. A simple model is devised for the galactic distribution of molecular clouds. The modeling results suggest that molecular clouds are essentially transient objects, existing for 15 to 40 million years after their formation in a spiral arm, and are largely confined to spiral features about 300 pc wide

Pengaruh Potensi Guru Dan Prasarana Terhadap Kinerja Guru Serta Implikasinya Pada Kualitas Pelayanan SMP Negeri 7 Bandung

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Annita Jannah

2012-10-01

Full Text Available This research was conducted in SMP Negeri 7 Bandung. The results of preliminary studies to obtain a finding that the quality of service of SMP Negeri 7 Bandung has not met expectations. Of the many determinants of the observed variables, allegedly because of the poor performance of teachers in the school. While the teacher's performance due to the competency of teachers and facilities infrastructure. Based on this, the formulated problem is how the competence of teachers, facilities infrastructure, teacher performance and quality of service. And how the influence of teacher competence and infrastructure facilities on teacher performance, either partially or simultaneously, as well as how the influence of the teacher's performance against quality of service. The method used is descriptive method of analysis, the number of respondents 55 teachers (population. The data analysis technique used is the technique of correlation analysis and path analysis techniques. As well as a simple regression analysis techniques to determine the effect of teacher performance against quality of service. In the operationalization used SPSS 17 and Excel. The results showed that the competence of teachers are in the good category, workshop facilities located in both categories, the performance of teachers in the category very good and the service quality is very good category. Some suggestions can be expressed as follows: learner characteristics Mastery, Mastery learning theory and principles of learning, curriculum development with subjects, utilization of information and communication technology for the sake of learning effectively, schools should be able to provide a positive influence on the development of students. Efforts to improve the quality of service should be seen from the teaching and learning process run smoothly, schedule lessons run right / discipline, Security during the learning process, built up good communication between faculty, staff and students

Exploring RNA structure by integrative molecular modelling

DEFF Research Database (Denmark)

Masquida, Benoît; Beckert, Bertrand; Jossinet, Fabrice

2010-01-01

RNA molecular modelling is adequate to rapidly tackle the structure of RNA molecules. With new structured RNAs constituting a central class of cellular regulators discovered every year, the need for swift and reliable modelling methods is more crucial than ever. The pragmatic method based...... on interactive all-atom molecular modelling relies on the observation that specific structural motifs are recurrently found in RNA sequences. Once identified by a combination of comparative sequence analysis and biochemical data, the motifs composing the secondary structure of a given RNA can be extruded...

B40 fullerene as a highly sensitive molecular device for NH3 detection at low bias: a first-principles study

International Nuclear Information System (INIS)

Lin, Bin; Dong, Huilong; Du, Chunmiao; Hou, Tingjun; Lin, Haiping; Li, Youyong

2016-01-01

The adsorption of small molecules (NH 3 , N 2 , H 2 and CH 4 ) on all-boron fullerene B 40 is investigated by density functional theory (DFT) and the non-equilibrium Green’s function (NEGF) for its potential application in the field of single-molecular gas sensors. The high adsorption energies (−1.09 to −0.75 eV) of NH 3 on different adsorption sites of the B 40 surface indicate that NH 3 strongly chemisorbs to B 40 . The charge transfer induced by the NH 3 adsorption results in a modification of the density of states (DOS) of B 40 near the Fermi level, and therefore changes its electronic transport properties. For all possible adsorption sites, the adsorption of NH 3 exclusively leads to a decrease of the conductance of B 40 . Taking into consideration that the non-polar gas molecules (e.g. N 2 , H 2 and CH 4 ) are only physisorbed and show negligible effect on the conductance properties of B 40 , we would expect that B 40 can be used as a single-molecular gas sensor to distinguish NH 3 from non-polar gas molecules at low bias. (paper)

PENDEKATAN BRAINSTORMINGROUND-ROBIN UNTUK MENINGKATKAN KEMAMPUAN KOMUNIKASIMATEMATIS SISWA SMP

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Maya Siti Rohmah

2015-07-01

Full Text Available ABSTRAK Penelitian ini bertujuan untuk mengetahui peningkatan kemampuan komunikasi matematis siswa yang pembelajarannya menggunakan Brainstorming Round-Robin dibandingkan dengan siswa yang pembelajarannya konvensional. Penelitian kuasi eksperimen ini mengambil populasi siswa kelas VII pada salah satu SMP di kabupaten Bandung Barat dengan sampel 2 kelas. Dari dua kelas yang dipilih dalam penelitian ini, salah satunya digunakan sebagai kelas eksperimen yang memperoleh pembelajaran dengan pendekatan Brainstorming Round-Robin, sedangkan kelas lainnnya sebagai kelas kontrol yang pembelajarannya konvensional. Kedua kelompok diberikan pretes dan postes kemampuan komunikasi matematis. Data N-gain yang diperoleh diuji secara kuantitatif dengan uji perbedaan rerata nonparametrik Mann-Whitney. Hasil penelitian menunjukkan bahwa peningkatan kemampuan komunikasi matematis siswa yang mendapat pembelajaran dengan menggunakan pendekatan Brainstorming Round-Robin lebih baik daripada siswa yang pembelajarannya konvensional. Kata Kunci    :     Brainstorming Round-Robin, KomunikasiMatematis     ABSTRACT The aims of these research are to determine anincrease in mathematics communication of students who obtain learning using Round-Robin Brainstormingbetter thanstudents who receivedconventional learning. This quasi experimental take population all students at class VII in one of public secondary school in West Bandung district with 2 classes as sample. From this 2 classes choosen in this research, one of them as an experimental classthatacquirelearningwithRound-Robin Brainstormingapproach, and the other one as acontrol class that receive conventional learning. Both groups weregiven thepretest and posttest of mathematics communication. N-gain data obtainedquantitatively,testedwitha meandifference testnonparametricMann-Whitney. The results showedthat an achievement and increase inmathematics communication of students thatgetslearning using

Modeling of molecular weight and molecular weight distribution in slurry polymerization of propylene by Ziegler-Natta catalysts

International Nuclear Information System (INIS)

Khorasani, R.; Pourmahdian, S.

2007-01-01

The Precise prediction of polypropylene synthesized by heterogeneous Ziegler-Natta catalysts needs good knowledge of parameters affecting on polymerization. molecular weight and molecular weight distribution are among important characteristics of a polymer determining physical-mechanical properties. broadening of molecular weight distribution is an important and well known characteristic of polypropylene synthesized by heterogeneous Ziegler-Natta catalysts, So it is important to understand the origin of broad molecular weight. Two main factors in broadening molecular weight, namely mass transfer resistances and multiplicity of active sites, are discussed in this paper and a model including these factors is presented. Then we calculate molecular weight and molecular weight distribution by the model and compare our results with

A consistent transported PDF model for treating differential molecular diffusion

Science.gov (United States)

Wang, Haifeng; Zhang, Pei

2016-11-01

Differential molecular diffusion is a fundamentally significant phenomenon in all multi-component turbulent reacting or non-reacting flows caused by the different rates of molecular diffusion of energy and species concentrations. In the transported probability density function (PDF) method, the differential molecular diffusion can be treated by using a mean drift model developed by McDermott and Pope. This model correctly accounts for the differential molecular diffusion in the scalar mean transport and yields a correct DNS limit of the scalar variance production. The model, however, misses the molecular diffusion term in the scalar variance transport equation, which yields an inconsistent prediction of the scalar variance in the transported PDF method. In this work, a new model is introduced to remedy this problem that can yield a consistent scalar variance prediction. The model formulation along with its numerical implementation is discussed, and the model validation is conducted in a turbulent mixing layer problem.

Testing the molecular clock using mechanistic models of fossil preservation and molecular evolution.

Science.gov (United States)

Warnock, Rachel C M; Yang, Ziheng; Donoghue, Philip C J

2017-06-28

Molecular sequence data provide information about relative times only, and fossil-based age constraints are the ultimate source of information about absolute times in molecular clock dating analyses. Thus, fossil calibrations are critical to molecular clock dating, but competing methods are difficult to evaluate empirically because the true evolutionary time scale is never known. Here, we combine mechanistic models of fossil preservation and sequence evolution in simulations to evaluate different approaches to constructing fossil calibrations and their impact on Bayesian molecular clock dating, and the relative impact of fossil versus molecular sampling. We show that divergence time estimation is impacted by the model of fossil preservation, sampling intensity and tree shape. The addition of sequence data may improve molecular clock estimates, but accuracy and precision is dominated by the quality of the fossil calibrations. Posterior means and medians are poor representatives of true divergence times; posterior intervals provide a much more accurate estimate of divergence times, though they may be wide and often do not have high coverage probability. Our results highlight the importance of increased fossil sampling and improved statistical approaches to generating calibrations, which should incorporate the non-uniform nature of ecological and temporal fossil species distributions. © 2017 The Authors.

75 FR 52292 - Airworthiness Directives; Diamond Aircraft Industries GmbH Models DA 40 and DA 40F Airplanes

Science.gov (United States)

2010-08-25

... Industries GmbH Models DA 40 and DA 40F Airplanes AGENCY: Federal Aviation Administration (FAA), Department... new airworthiness directive (AD) for all Diamond Aircraft Industries GmbH Models DA 40 and DA 40F... received information from Diamond Aircraft Industries GmbH that the Models DA 40 and DA 40F airplanes have...

PENGEMBANGAN MEDIA KOMIK IPA UNTUK MENINGKATKAN MOTIVASI BELAJAR DAN KARAKTER PESERTA DIDIK SMP

Directory of Open Access Journals (Sweden)

Ani Widyawati

2015-04-01

Full Text Available The objectives of this research were (1 to know the characteristics, (2 to review the advisability, and (3 to find out whether the science comic improve students learning motivation and character. This research is classified to Research and Development (R & D by referring to the ten main procedures developed by Borg and Gall. However this research only applied nine of the ten procedures stated above, they were: introduction, planning, developing, early try out, revision, limited try out, and final product revision. The subject of this research was grade VIII students of SMP Muhammadiyah 2 Yogyakarta. There were 43 respondents consisting of 5 students for individual try out, 10 students for small group try out, and 28 students for field try out. The data collecting instruments were validation sheet for media and material experts, observation sheet, interview guidelines, and students’character and motivation questionnaire sheet. The result of this research are as follows: (1 the characteristic of science comic were character-based and contained integrated science's material, (2 the advisability of character education-based science comic is considered as very good, and (3 therefore, the comics are applicate to develop motivation and character for JHS students.

Constructing Molecular Models with Low-Cost Toy Beads

Science.gov (United States)

Ng, Pun-hon; Wong, Siu-ling; Mak, Se-yuen

2012-01-01

In teaching the science of the nano world, ball-and-stick molecular models are frequently used as 3D representations of molecules. Unlike a chemical formula, a molecular model allows us to visualise the 3D shape of the molecule and the relative positions of its atoms, the bonds between atoms and why a pair of mirror isomers with the same atoms,…

Molecular Simulation towards Efficient and Representative Subsurface Reservoirs Modeling

KAUST Repository

Kadoura, Ahmad Salim

2016-01-01

This dissertation focuses on the application of Monte Carlo (MC) molecular simulation and Molecular Dynamics (MD) in modeling thermodynamics and flow of subsurface reservoir fluids. At first, MC molecular simulation is proposed as a promising method

Kontribusi Stabilitas Emosi Terhadap Kemampuan Pembuatan Keputusan Karier Siswa SMP

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Ahmad Fajri

2017-07-01

Full Text Available Contributions Emotion Stability to Career Decision Making Ability of SMP Students. This research is motivated by the career decision-making abilities of students of class IX are still easily influenced by the environment, it is because students feel anxious not appropriate selection of subsequent studies. Identified emotion stability can provide a positive influence on career decision-making abilities, like not anxious, to understand the feelings of others, and is able to accept the other person's perspective. In general the studies carried out to determine the contribution of emotion stability to the career decision-making abilities of students class IX SMPN 26 Bandung Academic Year 2016/2017. The research approach using a quantitative approach to the study correlational. The samples used were all students of class IX SMPN 26 Bandung academic year of 2016/2017 as many as 286 people. The results showed that (1 the emotion stability of students that are in the category of less stable with a percentage of 66.4%, (2 the ability of making career decisions of students in the category capable with a percentage of 53.5%, (3 there is a positive contribution and significant emotion stability of 16.7% against the career decision-making abilities of students, meaning that the diversity of career decision-making ability scores of students of class IX SMPN 26 Bandung determined by emotion stability student of 16.7%. The results of this analysis can be considered state aid students in the focus of guidance and counseling services.

AN ERROR ANALYSIS OF ENGLISH SIMPLE PRESENT TENSE OF THE SECOND YEAR STUDENTS OF SMP N 1 SUSUKAN REGENCY OF SEMARANG IN THE ACADEMIC YEAR 2003/2004

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Agus Safudin

2016-07-01

Full Text Available The aim of this research is to find out how far the errors of simple present tense produced bythe second year students of SMP N 1 Susukan. The research was conducted at State Junior High School (SMP N 1 Susukan, Regency of Semarang, Central Java, Indonesia. The objects of this research were the eighth graders. This is quantitative research. The writer uses random sampling by lottery. There are about 75 students and the writer took 50% as the sample.The errors made by the students were divided into eight aspects. (1 Error in using auxiliary is 36.75%. (2 Error in using plural noun is 22.90%. (3 Error in using to be is (am, is, are, is 7.69%.(4 Error in adverb of manneris 4.27%. (5 Error in using verb in simple present tense is 4.78%. (6 Error in using possessive sentence 5.24%. (7 Error in using imperative sentence is 0.34%. (8 Error due to ignorant is 11.28%. Relating to those errors there should be the preventing efforts by the teachers such as providing lots of examples of English and Indonesian sentences so that the students have greater understanding about the difference of those languages.

Molecular dynamics modeling of polymer flammability

International Nuclear Information System (INIS)

Nyden, M.R.; Brown, J.E.; Lomakin, S.M.

1992-01-01

Molecular dynamic simulations were used to identify factors which promote char formation during the thermal degradation of polymers. Computer movies based on these simulations, indicate that cross-linked model polymers tend to undergo further cross-linking when burned, eventually forming a high molecular weight, thermally stable char. This paper reports that the prediction was confirmed by char yield measurements made on γ and e - -irradiated polyethylene and chemically cross-linked poly(methyl methacrylate)

PENGARUH MOTIVASI BELAJAR DAN KOMPETENSI PROFESIONAL GURU TERHADAP PRESTASI BELAJAR MATA PELAJARAN IPS EKONOMI SISWA KELAS VII SMP NEGERI 3 MAGELANG TAHUN PELAJARAN 2011/2012

Directory of Open Access Journals (Sweden)

Yunik Sulistyowati,

2012-10-01

Full Text Available Prestasi belajar merupakan indikator yang penting untuk mengukur keberhasilan proses belajar mengajar. Prestasi belajar dipengaruhi oleh banyak faktor, di antaranya motivasi belajar dan kompetensi profesional guru. Permasalahan dalam penelitian ini adalah adakah pengaruh motivasi belajar dan kompetensi profesional guru terhadap prestasi belajar IPS ekonomi siswa kelas VII SMP Negeri 3 Magelang Tahun Ajaran 2011/2012 baik secara simultan maupun parsial.Populasi penelitian ini adalah siswa kelas VII SMP Negeri 3 Magelang dengan sampel berjumlah 133 siswa. Variabel penelitian terdiri dari variabel bebas yaitu motivasi belajar (X1 dan kompetensi profesional guru (X2, dan variabel terikat yaitu prestasi belajar (Y. Metode pengumpulan data menggunakan angket dan dokumentasi. Hasil penelitian deskriptif persentase menunjukkan bahwa motivasi belajar siswa dalam kategori tinggi, kompetensi profesional guru� dalam kategori baik, dan prestasi belajar siswa dalam kategori tuntas. Hasil penelitian diperoleh persamaan regresi yaitu ?= 48,387 + 0,607(X1 + 0,101(X2. Dari hasil uji F diperoleh nilai signifikan sebesar 0,000 dan menunjukkan bahwa secara simultan ada pengaruh yang signifikan antara motivasi belajar dan kompetensi profesional guru terhadap prestasi belajar IPS ekonomi sebesar 47,7% sedangkan sisanya 52,3% dipengaruhi oleh faktor lain yang tidak dikaji dalam penelitian ini. Secara parsial menunjukkan bahwa ada pengaruh antara motivasi belajar terhadap prestasi belajar sebesar 22,09%, dan ada pengaruh kompetensi profesional guru terhadap prestasi belajar sebesar 28,40%. Learning achievement is an indicator that it is important to measure the success of the process of teaching and learning. Learning achievement are influenced by many factors, such as learning motivation and teacher�s professional competence.The problem in this study is whether there is influence of learning motivation and teacher�s professional competence toward learning

Investigating the Fundamentals of Molecular Depth Profiling Using Strong-field Photoionization of Sputtered Neutrals

Science.gov (United States)

Willingham, D.; Brenes, D. A.; Winograd, N.; Wucher, A.

2010-01-01

Molecular depth profiles of model organic thin films were performed using a 40 keV C60+ cluster ion source in concert with TOF-SIMS. Strong-field photoionization of intact neutral molecules sputtered by 40 keV C60+ primary ions was used to analyze changes in the chemical environment of the guanine thin films as a function of ion fluence. Direct comparison of the secondary ion and neutral components of the molecular depth profiles yields valuable information about chemical damage accumulation as well as changes in the molecular ionization probability. An analytical protocol based on the erosion dynamics model is developed and evaluated using guanine and trehalose molecular secondary ion signals with and without comparable laser photoionization data. PMID:26269660

IMPLEMENTASI MODEL PEMBELAJARAN KOOPERATIF TALKING CHIPS DAN FAN-N-PICK DALAM MENINGKATKAN MOTIVASI DAN HASIL BELAJAR IPS

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Petrus Logo Radja

2017-09-01

Full Text Available This study is aimed to describe how Talking Chips and Fan-N-Pick learning model to improve VIII D class students’ motivation and learning outcomes at SMP Kristen Citra Bangsa Kota Kupang. The study is a Classroom Action Research (CAR study. The study consists of four phases, i.e. plan, action, observation, and reflection. The phases in CAR are conducted in 2 cycles. The subject of the study is 20 VIII D class students of SMP Kristen Citra Bangsa Kota Kupang. The collected data consists of students’ motivation and learning result test. The result of the study shows that there is an improvement on students’ motivation in the first cycle and the high criteria is improved to very high criteria in the end of the second cycle. The improvement is also occurred in students’ learning outcome and implementation whether it is from the students or the teacher. Penelitian ini bertujuan untuk mendeskripsikan bagaimana penerapan model pembelajaran Talking Chips dan Fan-N-Pick untuk meningkatkan motivasi dan hasil belajar siswa kelas VIII-D di SMP Kristen Citra Bangsa Kota Kupang. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK. Penelitian ini terdiri atas empat tahap, yaitu tahap perencanaan, pelaksanaan, pengamatan/observasi dan refleksi. Tahapan dalam PTK ini dilaksanakan dalam dua siklus. Subjek dalam penelitian ini ialah siswa kelas VIII-D SMP Kristen Citra Bangsa Kupang yang berjumlah 20 orang. Data yang dikumpulkan dalam penelitian ini adalah motivasi siswa dan tes hasil belajar. Hasil penelitian menunjukan terjadinya peningkatan motivasi siswa pada siklus I dengan kriteria tinggi meningkat menjadi sangat tinggi pada akhir siklus II. Peningkatan juga terjadi pada hasil belajar siswa dan keterlaksanaan pembelajaran baik oleh guru dan siswa.

The independent molecular interaction sites model. Pt. 1

International Nuclear Information System (INIS)

Naumann, K.H.; Lippert, E.

1981-01-01

A new reference system for the treatment of molecular fluids within the framework of thermodynamic perturbation theory is presented. The basic ingredient of our approach is a potential transformation which allows us to view molecular liquids and gases as mixtures of formally independent molecular interaction sites (IMIS model). Some relations between out method and the RAM theory are discussed. (orig.)

A hybrid parallel framework for the cellular Potts model simulations

Energy Technology Data Exchange (ETDEWEB)

Jiang, Yi [Los Alamos National Laboratory; He, Kejing [SOUTH CHINA UNIV; Dong, Shoubin [SOUTH CHINA UNIV

2009-01-01

The Cellular Potts Model (CPM) has been widely used for biological simulations. However, most current implementations are either sequential or approximated, which can't be used for large scale complex 3D simulation. In this paper we present a hybrid parallel framework for CPM simulations. The time-consuming POE solving, cell division, and cell reaction operation are distributed to clusters using the Message Passing Interface (MPI). The Monte Carlo lattice update is parallelized on shared-memory SMP system using OpenMP. Because the Monte Carlo lattice update is much faster than the POE solving and SMP systems are more and more common, this hybrid approach achieves good performance and high accuracy at the same time. Based on the parallel Cellular Potts Model, we studied the avascular tumor growth using a multiscale model. The application and performance analysis show that the hybrid parallel framework is quite efficient. The hybrid parallel CPM can be used for the large scale simulation ({approx}10{sup 8} sites) of complex collective behavior of numerous cells ({approx}10{sup 6}).

PENGEMBANGAN PERANGKAT PEMBELAJARAN IPA MODEL 5E DI SMP

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Hairul Anwar

2016-02-01

Kata kunci: perangkat pembelajaran IPA, model 5E, penelitian pengembangan THE DEVELOPMENT OF 5E MODEL OF SCIENCE TEACHING KITS IN JUNIOR HIGH SCHOOL Abstract: The purpose of this study was to develop the 5E model science teaching kits in Junior High School 2 Kopang. This was a research and development study referring to Dick and Carey model. The formative evaluation stage wasdone by: (1 the validation of the kitsby 3 experts and 1 teacher as users, (2 the limited trial on the teaching kits (syllabus, lesson plan, and students’ worksheets held in grade VII, and (3 the validation of the assessment instrument (Science Process Skills/SPS test, Cognitive Achievement/CA test and Affective Achievement/AA questionnaires held in VIII. The average score of the validation result showed that all teaching kits were suitable to be used in the limited trial. The use of the teaching kits (syllabus and lesson plan in the limited trial obtainedpositive responses from the teacher of grade VII as the observer with an average score of 4.20 and “strongly-agree” responses from students with an average score 4.12. The students also showed strong agreement on the worksheets with an average score of 4.14. The result of the validity and reliability test on the instrument showed that all the items of the SPS test, those of the CA test, and those of the AA questionnaires were valid. The Cronbach’s alpha reliability coefficient was > 0.423. Keywords: science teachingkits, the 5E model, research and development

Molecular modeling of inorganic compounds

National Research Council Canada - National Science Library

Comba, Peter; Hambley, Trevor W; Martin, Bodo

2009-01-01

... mechanics to inorganic and coordination compounds. Initially, simple metal complexes were modeled, but recently the field has been extended to include organometallic compounds, catalysis and the interaction of metal ions with biological macromolecules. The application of molecular mechanics to coordination compounds is complicated by the numbe...

Agent-Based Modeling in Molecular Systems Biology.

Science.gov (United States)

Soheilypour, Mohammad; Mofrad, Mohammad R K

2018-06-08

Molecular systems orchestrating the biology of the cell typically involve a complex web of interactions among various components and span a vast range of spatial and temporal scales. Computational methods have advanced our understanding of the behavior of molecular systems by enabling us to test assumptions and hypotheses, explore the effect of different parameters on the outcome, and eventually guide experiments. While several different mathematical and computational methods are developed to study molecular systems at different spatiotemporal scales, there is still a need for methods that bridge the gap between spatially-detailed and computationally-efficient approaches. In this review, we summarize the capabilities of agent-based modeling (ABM) as an emerging molecular systems biology technique that provides researchers with a new tool in exploring the dynamics of molecular systems/pathways in health and disease. © 2018 WILEY Periodicals, Inc.

Shape forming by thermal expansion mismatch and shape memory locking in polymer/elastomer laminates

Science.gov (United States)

Yuan, Chao; Ding, Zhen; Wang, T. J.; Dunn, Martin L.; Qi, H. Jerry

2017-10-01

This paper studies a novel method to fabricate three-dimensional (3D) structure from 2D thermo-responsive shape memory polymer (SMP)/elastomer bilayer laminate. In this method, the shape change is actuated by the thermal mismatch strain between the SMP and the elastomer layers upon heating. However, the glass transition behavior of the SMP locks the material into a new 3D shape that is stable even upon cooling. Therefore, the second shape becomes a new permanent shape of the laminate. A theoretical model that accounts for the temperature-dependent thermomechanical behavior of the SMP material and thermal mismatch strain between the two layers is developed to better understand the underlying physics. Model predictions and experiments show good agreement and indicate that the theoretical model can well predict the bending behavior of the bilayer laminate. The model is then used in the optimal design of geometrical configuration and material selection. The latter also illustrates the requirement of thermomechanical behaviors of the SMP to lock the shape. Based on the fundamental understandings, several self-folding structures are demonstrated by the bilayer laminate design.

Realistic molecular model of kerogen's nanostructure.

Science.gov (United States)

Bousige, Colin; Ghimbeu, Camélia Matei; Vix-Guterl, Cathie; Pomerantz, Andrew E; Suleimenova, Assiya; Vaughan, Gavin; Garbarino, Gaston; Feygenson, Mikhail; Wildgruber, Christoph; Ulm, Franz-Josef; Pellenq, Roland J-M; Coasne, Benoit

2016-05-01

Despite kerogen's importance as the organic backbone for hydrocarbon production from source rocks such as gas shale, the interplay between kerogen's chemistry, morphology and mechanics remains unexplored. As the environmental impact of shale gas rises, identifying functional relations between its geochemical, transport, elastic and fracture properties from realistic molecular models of kerogens becomes all the more important. Here, by using a hybrid experimental-simulation method, we propose a panel of realistic molecular models of mature and immature kerogens that provide a detailed picture of kerogen's nanostructure without considering the presence of clays and other minerals in shales. We probe the models' strengths and limitations, and show that they predict essential features amenable to experimental validation, including pore distribution, vibrational density of states and stiffness. We also show that kerogen's maturation, which manifests itself as an increase in the sp(2)/sp(3) hybridization ratio, entails a crossover from plastic-to-brittle rupture mechanisms.

PENGARUH MODEL PEMBELAJARAN LEARNING CYCLE TERHADAP KETERAMPILAN BERPIKIR KRITIS SISWA

Directory of Open Access Journals (Sweden)

Aryani Novianti

2015-03-01

Full Text Available Tujuan dari penelitian ini adalah untuk mengetahui pengaruh model pembelajaran Learning Cycle pada konsep Sistem Pencernaan pada Manusia terhadap keterampilan berpikir kritis siswa. Adapun model pembelajaran Learning Cycle yang diterapkan adalah jenis 5E (Engangement, Exploration, Explanation, Elaboration dan Evaluation. Populasi dari penelitian ini adalah seluruh siswa kelas VIII SMP N 9 Kota Tangerang Selatan sedangkan sampelnya adalah seluruh siswa di kelas VIII 7 (38 orang dan VIII 8 (38 orang SMP N 9 Kota Tangsel. Teknik pengambilan sampel dalam penelitian ini dilakukan dengan teknik Sampling Purposive. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian Quasi-eksperimental design dengan desain penelitian berupa nonequivalent control group design. Instrumen yang digunakan berupa tes tertulis berupa pilihan ganda dan esai yang ditujukan untuk mengukur keterampilan berpikir kritis. Sedangkan lembar observasi digunakan untuk mengamati keterlaksanaan model pembelajaran Learning Cycle oleh guru dan keterampilan berpikir kritis yang tergali oleh siswa. Analisis data menggunakan uji-t diperoleh hasil thitung 3,703 dan ttabel pada taraf signifikansi 5 % sebesar 2, maka thitung > ttabel. Hal ini dapat disimpulkan bahwa penerapan model pembelajaran Learning Cycle pada konsep Sistem Pencernaan pada Manusia berpengaruh terhadap keterampilan berpikir kritis siswa.

MODEL PENGASUHAN ANALISIS TRANSAKSIONAL (AT UNTUK MENANGGULANGI PENYIMPANGAN PERILAKU SEKSUAL DI KALANGAN REMAJA KABUPATEN BULELENG (Studi pada Sekolah SMP/SMA yang Memiliki Siswa Terindikasi

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Gede Sedanayasa

2015-05-01

Full Text Available Penelitian tahun pertama ini, bertujuan untuk mengidentifikasi harapan orang tua terhadap remaja dan harapan remaja terhadap orang tua.  Harapan dua pihak ini dijadikan bahan analisis transaksi pengasuhan orang tua dalam keluarga. Subjek penelitian adalah siswa-siswa SMP/SMA dan orang tua yang anak-anaknya terindikasi melakukan perilaku seksual menyimpang pada lima sekolah di Kabupaten Buleleng. Data  dikumpulkan dengan pencatatan dokumen, kuesioner, dan wawancara. Data  dianalisis dengan analisis deskriptif kuantitatif.  Hasil penelitian menunjukkan  bahwa,   remaja dan orang tua sama-sama memiliki harapan yang baik untuk keberlangsungan perkembangan keluarga hanya,  kedua pihak  tidak saling  memahami harapan masing-masing. Pihak remaja misalnya, mengharapkan agar orang tua dapat memenuhi kebutuhan sekolah secara layak dan ikhlas, dapat membimbing perkembangannya termasuk membantu memecahkan masalah belajar, sedangkan orang tua berharap agar remaja berperilaku hormat, tidak melecehkan orang tua, tidak membantah, patuh aturan keluarga dan sekolah, dan  meminta maaf jika keliru. Disarankan kepada ke dua pihak  (remaja dan orang tua untuk saling memahami keadaan masing-masing. Dari pihak remaja, dalam mengharapkan sesuatu tidak memaksakan kehendak, dan sebaliknya orang tua tetap memandang remaja sebagai individu yang berkembang, butuh perhatian dan penghargaan, sehingga memperlakukannya secara manusiawi.

Characterization of soluble microbial products and their fouling impacts in membrane bioreactors

KAUST Repository

Jiang, Tao; Kennedy, Maria Dolores; Schepper, Veerle D.; Nam, Seongnam; Nopens, Ingmar; Vanrolleghem, Peter A.; Amy, Gary L.

2010-01-01

Membrane bioreactor (MBR) fouling is not only influenced by the soluble microbial products (SMP) concentration but by their characteristics. Experiments of separate producing biomass associated products (BAP) and utilization associated products (UAP) allowed the separation of BAP and UAP effects from sludge water (SW). Thus, filtration of individual SMP components and further characterization becomes possible. Unstirred cell filtration was used to study fouling mechanisms and liquid chromatography-organic carbon detection (LC-OCD) and fluorescence excitation-emission matrix (EEM) were used to characterize the foulant. Generally, the SMP exhibiting characteristics of higher molecular weight, greater hydrophilicity and a more reduced state showed a higher retention percentage. However, the higher retention does not always yield higher fouling effects. The UAP filtration showed the highest specific cake resistance and pore blocking resistance attributed to their higher percentage of low molecular weight molecules, although their retention percentage was lower than the SW and BAP filtration. The UAP produced in the cell proliferation phase appeared to have the highest fouling potential. © 2010 American Chemical Society.

Characterization of soluble microbial products and their fouling impacts in membrane bioreactors

KAUST Repository

Jiang, Tao

2010-09-01

Membrane bioreactor (MBR) fouling is not only influenced by the soluble microbial products (SMP) concentration but by their characteristics. Experiments of separate producing biomass associated products (BAP) and utilization associated products (UAP) allowed the separation of BAP and UAP effects from sludge water (SW). Thus, filtration of individual SMP components and further characterization becomes possible. Unstirred cell filtration was used to study fouling mechanisms and liquid chromatography-organic carbon detection (LC-OCD) and fluorescence excitation-emission matrix (EEM) were used to characterize the foulant. Generally, the SMP exhibiting characteristics of higher molecular weight, greater hydrophilicity and a more reduced state showed a higher retention percentage. However, the higher retention does not always yield higher fouling effects. The UAP filtration showed the highest specific cake resistance and pore blocking resistance attributed to their higher percentage of low molecular weight molecules, although their retention percentage was lower than the SW and BAP filtration. The UAP produced in the cell proliferation phase appeared to have the highest fouling potential. © 2010 American Chemical Society.

Thermoviscoelastic shape memory behavior for epoxy-shape memory polymer

International Nuclear Information System (INIS)

Chen, Jianguo; Liu, Liwu; Liu, Yanju; Leng, Jinsong

2014-01-01

There are various applications for shape memory polymer (SMP) in the smart materials and structures field due to its large recoverable strain and controllable driving method. The mechanical shape memory deformation mechanism is so obscure that many samples and test schemes have to be tried in order to verify a final design proposal for a smart structure system. This paper proposes a simple and very useful method to unambiguously analyze the thermoviscoelastic shape memory behavior of SMP smart structures. First, experiments under different temperature and loading conditions are performed to characterize the large deformation and thermoviscoelastic behavior of epoxy-SMP. Then, a rheological constitutive model, which is composed of a revised standard linear solid (SLS) element and a thermal expansion element, is proposed for epoxy-SMP. The thermomechanical coupling effect and nonlinear viscous flowing rules are considered in the model. Then, the model is used to predict the measured rubbery and time-dependent response of the material, and different thermomechanical loading histories are adopted to verify the shape memory behavior of the model. The results of the calculation agree with experiments satisfactorily. The proposed shape memory model is practical for the design of SMP smart structures. (paper)

PERSEPSI DALAM PEMBELAJARAN PENDEKATAN KETERAMPILAN PROSES TERHADAP KEMAMPUAN KONEKSI MATEMATIS SISWA (STUDI PENELITIAN DI SMP NEGERI 1 WANRAJA

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Rini Pitriani

2017-01-01

Full Text Available Kemampuan koneksi matematis merupakan hal yang penting namun siswa yang menguasai konsep matematika tidak dengan sendirinya pintar dalam mengoneksikan matematika. Koneksi matematis merupakan suatu keterampilan yang harus dibangun dan dipelajari. Kegiatan penyelesaian masalah kontekstual merupakan aktivitas yang membantu siswa untuk dapat mengetahui hubungan berbagai konsep dalam matematika dan mengaplikasikan matematika dalam kehidupan sehari-hari. Pendekatan keterampilan proses pada hakikatnya adalah suatu pengelolaan kegiatan belajar-mengajar yang berfokus pada pelibatan siswa secara aktif dan kreatif dalam proses pemerolehan hasil belajar. Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh persepsi siswa tentang pembelajaran pendekatan keterampilan proses terhadap kemampuan koneksi matematis siswa dalam pengajaran matematika pada pokok bahasan Lingkaran. Jenis penelitian yang digunakan adalah eksperimen. Populasi dalam penelitian ini adalah seluruh siswa kelas VIII SMP Negeri 1 Wanaraja dan untuk sampel dipilih satu kelas yang diambil secara acak, yaitu kelas VIII-A. Dalam penelitian ini penulis menggunakan instrumen yang terdiri dari tes kemampuan koneksi berupa tes uraian (tes akhir yang sebelumnya di uji cobakan kepada siswa kelas 1X-A di SMP Negeri 1 Wanaraja dan angket. Analisis data dilakukan dengan korelasi Rank Sperman dan dilanjutkan dengan uji t,dari perhitungan diperoleh Ho ditolak, artinya Ha diterima sehingga terdapat pengaruh yang positif persepsi siswa tentang pembelajaran pendekatan keterampilan proses (PKP terhadap kemampuan koneksi matematis siswa. Sedangkan untuk analisis kemampuan koneksi matematis siswa secara keseluruhan berinterpretasi baik dan persepsi siswa terhadap pembelajaran matematika dengan Pendekatan Keterampilan Proses menunjukan interpretasi yang baik pula. Kata kunci: kemampuan koneksi matematis, pendekatan keterampilan proses, persepsi siswa, penelitian   eksperimen Mathematical connection

Transient thermal analysis for radioactive liquid mixing operations in a large-scaled tank

International Nuclear Information System (INIS)

Lee, S. Y.; Smith, F. G. III

2014-01-01

A transient heat balance model was developed to assess the impact of a Submersible Mixer Pump (SMP) on radioactive liquid temperature during the process of waste mixing and removal for the high-level radioactive materials stored in Savannah River Site (SRS) tanks. The model results will be mainly used to determine the SMP design impacts on the waste tank temperature during operations and to develop a specification for a new SMP design to replace existing longshaft mixer pumps used during waste removal. The present model was benchmarked against the test data obtained by the tank measurement to examine the quantitative thermal response of the tank and to establish the reference conditions of the operating variables under no SMP operation. The results showed that the model predictions agreed with the test data of the waste temperatures within about 10%

Synthesis, Biological Evaluation and Molecular Modelling of 2′-Hydroxychalcones as Acetylcholinesterase Inhibitors

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Sri Devi Sukumaran

2016-07-01

Full Text Available A series of 2′-hydroxy- and 2′-hydroxy-4′,6′-dimethoxychalcones was synthesised and evaluated as inhibitors of human acetylcholinesterase (AChE. The majority of the compounds were found to show some activity, with the most active compounds having IC50 values of 40–85 µM. Higher activities were generally observed for compounds with methoxy substituents in the A ring and halogen substituents in the B ring. Kinetic studies on the most active compounds showed that they act as mixed-type inhibitors, in agreement with the results of molecular modelling studies, which suggested that they interact with residues in the peripheral anionic site and the gorge region of AChE.

FROM ATOMISTIC TO SYSTEMATIC COARSE-GRAINED MODELS FOR MOLECULAR SYSTEMS

KAUST Repository

Harmandaris, Vagelis

2017-10-03

The development of systematic (rigorous) coarse-grained mesoscopic models for complex molecular systems is an intense research area. Here we first give an overview of methods for obtaining optimal parametrized coarse-grained models, starting from detailed atomistic representation for high dimensional molecular systems. Different methods are described based on (a) structural properties (inverse Boltzmann approaches), (b) forces (force matching), and (c) path-space information (relative entropy). Next, we present a detailed investigation concerning the application of these methods in systems under equilibrium and non-equilibrium conditions. Finally, we present results from the application of these methods to model molecular systems.

Two-Dimensional Model of Scrolled Packings of Molecular Nanoribbons

Science.gov (United States)

Savin, A. V.; Mazo, M. A.

2018-04-01

A simplified model of the in-plane molecular chain, allowing the description of folded and scrolled packings of molecular nanoribbons of different structures, is proposed. Using this model, possible steady states of single-layer nanoribbons scrolls of graphene, graphane, fluorographene, and fluorographane (graphene hydrogenated on the one side and fluorinated on the other side) are obtained. Their stability is demonstrated and their energy is calculated as a function of the nanoribbon length. It is shown that the scrolled packing is the most energetically favorable nanoribbon conformation at long lengths. The existences of scrolled packings for fluorographene nanoribbons and the existence of two different scroll types corresponding to left- and right-hand Archimedean spirals for fluorographane nanoribbons in the chain model are shown for the first time. The simplicity of the proposed model makes it possible to consider the dynamics of scrolls of rather long molecular nanoribbons at long enough time intervals.

Senescence marker protein-30/superoxide dismutase 1 double knockout mice exhibit increased oxidative stress and hepatic steatosis

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Yoshitaka Kondo

2014-01-01

Full Text Available Superoxide dismutase 1 (SOD1 is an antioxidant enzyme that converts superoxide anion radicals into hydrogen peroxide and molecular oxygen. The senescence marker protein-30 (SMP30 is a gluconolactonase that functions as an antioxidant protein in mammals due to its involvement in ascorbic acid (AA biosynthesis. SMP30 also participates in Ca2+ efflux by activating the calmodulin-dependent Ca2+-pump. To reveal the role of oxidative stress in lipid metabolism defects occurring in non-alcoholic fatty liver disease pathogenesis, we generated SMP30/SOD1-double knockout (SMP30/SOD1-DKO mice and investigated their survival curves, plasma and hepatic lipid profiles, amounts of hepatic oxidative stress, and hepatic protein levels expressed by genes related to lipid metabolism. While SMP30/SOD1-DKO pups had no growth retardation by 14 days of age, they did have low plasma and hepatic AA levels. Thereafter, 39% and 53% of male and female pups died by 15–24 and 89 days of age, respectively. Compared to wild type, SMP30-KO and SOD1-KO mice, by 14 days SMP30/SOD1-DKO mice exhibited: (1 higher plasma levels of triglyceride and aspartate aminotransferase; (2 severe accumulation of hepatic triglyceride and total cholesterol; (3 higher levels of superoxide anion radicals and thiobarbituric acid reactive substances in livers; and (4 decreased mRNA and protein levels of Apolipoprotein B (ApoB in livers – ApoB is an essential component of VLDL secretion. These results suggest that high levels of oxidative stress due to concomitant deficiency of SMP30 and/or AA, and SOD1 cause abnormal plasma lipid metabolism, hepatic lipid accumulation and premature death resulting from impaired VLDL secretion.

Molecular modeling of nucleic Acid structure: electrostatics and solvation.

Science.gov (United States)

Bergonzo, Christina; Galindo-Murillo, Rodrigo; Cheatham, Thomas E

2014-12-19

This unit presents an overview of computer simulation techniques as applied to nucleic acid systems, ranging from simple in vacuo molecular modeling techniques to more complete all-atom molecular dynamics treatments that include an explicit representation of the environment. The third in a series of four units, this unit focuses on critical issues in solvation and the treatment of electrostatics. UNITS 7.5 & 7.8 introduced the modeling of nucleic acid structure at the molecular level. This included a discussion of how to generate an initial model, how to evaluate the utility or reliability of a given model, and ultimately how to manipulate this model to better understand its structure, dynamics, and interactions. Subject to an appropriate representation of the energy, such as a specifically parameterized empirical force field, the techniques of minimization and Monte Carlo simulation, as well as molecular dynamics (MD) methods, were introduced as a way of sampling conformational space for a better understanding of the relevance of a given model. This discussion highlighted the major limitations with modeling in general. When sampling conformational space effectively, difficult issues are encountered, such as multiple minima or conformational sampling problems, and accurately representing the underlying energy of interaction. In order to provide a realistic model of the underlying energetics for nucleic acids in their native environments, it is crucial to include some representation of solvation (by water) and also to properly treat the electrostatic interactions. These subjects are discussed in detail in this unit. Copyright © 2014 John Wiley & Sons, Inc.

Thermal–electric characterization and modelling of a smart composite structure for architectural applications

International Nuclear Information System (INIS)

Lelieveld, C M J L; Jansen, K M B

2014-01-01

A composite structure consisting of a shape memory polymer (SMP) matrix with embedded shape memory alloy (SMA) strips was constructed. The SMA strips acted as actuators in order to realize a reversible 90 degree deformation. The deformation was activated by local heating. The polymer matrix enabled the structural fixation of the deformations. The polymer showed rigid characteristics at a low temperature range. During the morphing stage, the polymer was heated locally to a rubbery condition to allow shape changes. The SMA actuators were able to deform the structure upon thermal activation, after which the new structural shape was fixated by cooling the polymer into a rigid, glassy state. Since the exact timing and amount of heating power of both the SMA strips and the SMP matrix was crucial for the functioning of the smart structure, a detailed numerical thermal model was built and validated using thermal imaging. With this validated numerical model the optimum activation conditions were determined. (papers)

Computer-Based Molecular Modelling: Finnish School Teachers' Experiences and Views

Science.gov (United States)

Aksela, Maija; Lundell, Jan

2008-01-01

Modern computer-based molecular modelling opens up new possibilities for chemistry teaching at different levels. This article presents a case study seeking insight into Finnish school teachers' use of computer-based molecular modelling in teaching chemistry, into the different working and teaching methods used, and their opinions about necessary…

A model for self-diffusion of guanidinium-based ionic liquids: a molecular simulation study.

Science.gov (United States)

Klähn, Marco; Seduraman, Abirami; Wu, Ping

2008-11-06

We propose a novel self-diffusion model for ionic liquids on an atomic level of detail. The model is derived from molecular dynamics simulations of guanidinium-based ionic liquids (GILs) as a model case. The simulations are based on an empirical molecular mechanical force field, which has been developed in our preceding work, and it relies on the charge distribution in the actual liquid. The simulated GILs consist of acyclic and cyclic cations that were paired with nitrate and perchlorate anions. Self-diffusion coefficients are calculated at different temperatures from which diffusive activation energies between 32-40 kJ/mol are derived. Vaporization enthalpies between 174-212 kJ/mol are calculated, and their strong connection with diffusive activation energies is demonstrated. An observed formation of cavities in GILs of up to 6.5% of the total volume does not facilitate self-diffusion. Instead, the diffusion of ions is found to be determined primarily by interactions with their immediate environment via electrostatic attraction between cation hydrogen and anion oxygen atoms. The calculated average time between single diffusive transitions varies between 58-107 ps and determines the speed of diffusion, in contrast to diffusive displacement distances, which were found to be similar in all simulated GILs. All simulations indicate that ions diffuse by using a brachiation type of movement: a diffusive transition is initiated by cleaving close contacts to a coordinated counterion, after which the ion diffuses only about 2 A until new close contacts are formed with another counterion in its vicinity. The proposed diffusion model links all calculated energetic and dynamic properties of GILs consistently and explains their molecular origin. The validity of the model is confirmed by providing an explanation for the variation of measured ratios of self-diffusion coefficients of cations and paired anions over a wide range of values, encompassing various ionic liquid classes

Molecular models and simulations of layered materials

International Nuclear Information System (INIS)

Kalinichev, Andrey G.; Cygan, Randall Timothy; Heinz, Hendrik; Greathouse, Jeffery A.

2008-01-01

The micro- to nano-sized nature of layered materials, particularly characteristic of naturally occurring clay minerals, limits our ability to fully interrogate their atomic dispositions and crystal structures. The low symmetry, multicomponent compositions, defects, and disorder phenomena of clays and related phases necessitate the use of molecular models and modern simulation methods. Computational chemistry tools based on classical force fields and quantum-chemical methods of electronic structure calculations provide a practical approach to evaluate structure and dynamics of the materials on an atomic scale. Combined with classical energy minimization, molecular dynamics, and Monte Carlo techniques, quantum methods provide accurate models of layered materials such as clay minerals, layered double hydroxides, and clay-polymer nanocomposites

Gradient Models in Molecular Biophysics: Progress, Challenges, Opportunities.

Science.gov (United States)

Bardhan, Jaydeep P

2013-12-01

In the interest of developing a bridge between researchers modeling materials and those modeling biological molecules, we survey recent progress in developing nonlocal-dielectric continuum models for studying the behavior of proteins and nucleic acids. As in other areas of science, continuum models are essential tools when atomistic simulations (e.g. molecular dynamics) are too expensive. Because biological molecules are essentially all nanoscale systems, the standard continuum model, involving local dielectric response, has basically always been dubious at best. The advanced continuum theories discussed here aim to remedy these shortcomings by adding features such as nonlocal dielectric response, and nonlinearities resulting from dielectric saturation. We begin by describing the central role of electrostatic interactions in biology at the molecular scale, and motivate the development of computationally tractable continuum models using applications in science and engineering. For context, we highlight some of the most important challenges that remain and survey the diverse theoretical formalisms for their treatment, highlighting the rigorous statistical mechanics that support the use and improvement of continuum models. We then address the development and implementation of nonlocal dielectric models, an approach pioneered by Dogonadze, Kornyshev, and their collaborators almost forty years ago. The simplest of these models is just a scalar form of gradient elasticity, and here we use ideas from gradient-based modeling to extend the electrostatic model to include additional length scales. The paper concludes with a discussion of open questions for model development, highlighting the many opportunities for the materials community to leverage its physical, mathematical, and computational expertise to help solve one of the most challenging questions in molecular biology and biophysics.

Gradient Models in Molecular Biophysics: Progress, Challenges, Opportunities

Science.gov (United States)

Bardhan, Jaydeep P.

2014-01-01

In the interest of developing a bridge between researchers modeling materials and those modeling biological molecules, we survey recent progress in developing nonlocal-dielectric continuum models for studying the behavior of proteins and nucleic acids. As in other areas of science, continuum models are essential tools when atomistic simulations (e.g. molecular dynamics) are too expensive. Because biological molecules are essentially all nanoscale systems, the standard continuum model, involving local dielectric response, has basically always been dubious at best. The advanced continuum theories discussed here aim to remedy these shortcomings by adding features such as nonlocal dielectric response, and nonlinearities resulting from dielectric saturation. We begin by describing the central role of electrostatic interactions in biology at the molecular scale, and motivate the development of computationally tractable continuum models using applications in science and engineering. For context, we highlight some of the most important challenges that remain and survey the diverse theoretical formalisms for their treatment, highlighting the rigorous statistical mechanics that support the use and improvement of continuum models. We then address the development and implementation of nonlocal dielectric models, an approach pioneered by Dogonadze, Kornyshev, and their collaborators almost forty years ago. The simplest of these models is just a scalar form of gradient elasticity, and here we use ideas from gradient-based modeling to extend the electrostatic model to include additional length scales. The paper concludes with a discussion of open questions for model development, highlighting the many opportunities for the materials community to leverage its physical, mathematical, and computational expertise to help solve one of the most challenging questions in molecular biology and biophysics. PMID:25505358

Spin models for the single molecular magnet Mn12-AC

Science.gov (United States)

Al-Saqer, Mohamad A.

2005-11-01

The single molecular magnet (SMM) Mn12-AC attracted the attention of scientists since the discovery of its magnetic hystereses which are accompanied by sudden jumps in magnetic moments at low temperature. Unlike conventional bulk magnets, hysteresis in SMMs is of molecular origin. This qualifies them as candidates for next generation of high density storage media where a molecule which is at most few nanometers in size can be used to store a bit of information. However, the jumps in these hystereses, due to spin tunneling, can lead to undesired loss of information. Mn12-AC molecule contains twelve magnetic ions antiferromagnetically coupled by exchanges leading to S = 10 ground state manifold. The magnetic ions are surrounded by ligands which isolate them magnetically from neighboring molecules. The lowest state of S = 9 manifold is believed to lie at about 40 K above the ground state. Therefore, at low temperatures, the molecule is considered as a single uncoupled moment of spin S = 10. Such model has been used widely to understand phenomena exhibited by the molecule at low temperatures including the tunneling of its spin, while a little attention has been paid for the multi-spin nature of the molecule. Using the 8-spin model, we demonstrate that in order to understand the phenomena of tunneling, a full spin description of the molecule is required. We utilized a calculation scheme where a fraction of energy levels are used in the calculations and the influence of levels having higher energy is neglected. From the dependence of tunnel splittings on the number of states include, we conclude that models based on restricting the number of energy levels (single-spin and 8-spin models) lead to unreliable results of tunnel splitting calculations. To attack the full 12-spin model, we employed the Davidson algorithm to calculated lowest energy levels produced by exchange interactions and single ion anisotropies. The model reproduces the anisotropy properties at low

Comparison and Analysis of 3,4 dihydrocylmandelic acid (DHMA) and noremetanephrine (NMN) on Amyloid-Beta 40 Monomer for treatment of Alzheimer's Disease using Molecular Dynamics Simulation

Science.gov (United States)

Choi, Woosung; Jee, Sang Eun; Jang, Seung Soon

Alzheimer's disease (AD) is type of degenerative dementia caused memory loss and behavior problem. Main reason of AD is Amyloid-Beta 40(A β) mostly composed of α -helix form misfolds to insoluble fibrils and soluble oilgomer. This insoluble fibrils aggregate with beta sheet structure and form the plaque which is caused nurotoxicity in brain. Both 3,4 dihydrocylmandelic acid (DHMA) and noremetanephrine (NMN) are the metabolite of norepinephrine in brain . Also these are inhibit the changing formation of fibrils and maintain the α -helix structure. In this computational modeling study, both NMN and DHMA molecules were modified and analyzed for specific effect on the A β-monomer using molecular dynamics simulation. Using molecular dynamic simulation, NMN and DHMA act as modulator on three A β-monomer batches and could observe the conformational changing of these A β-monomer under the physiologocal condition. This computational experiment is designed to compare and analyze both of chemicals for determining which chamecal would be more effective on the conformation of A β 40 monomer.

MENINGKATKAN KEMAMPUAN SERVICE DALAM PERMAINAN BOLA VOLLY DENGAN MAKE A MATCH PADA SISWA KELAS VII-H SMP NEGERI 1 WONOASRI

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Anik Sri Handayani

2016-11-01

Full Text Available In the learning process of Physical Education in, teachers are expected to teach varieties of basic motor skills, techniques and strategy of games and sports, internalization of values (sportsmanship, honesty, cooperation, etc. as well as the conditioning of healthy lifestyles. The implementation is not through conventional teaching in the classroom consisting theoretical studies, but it also involves elements of physical, mental, intellectual, emotional and social. The activities which are given in teaching should get a methodical didactic touch, so that the activities carried out can achieve the aim of teaching. The problem formulation of this research is: is there an increase in the ability of service in the game of volleyball with “make-match” at VII-H grade of SMP Negeri 1 Wonoasri in 2012/2013 academic year? The purpose Classroom Action Research (CAR is to improve the quality of learning on the physical education in doing “service” in a volleyball game through a “make-match” learning approach  In this study, researchers have collaboration with other teachers and the principal. Researchers are involved in the study from the beginning to the end of the researech. Researchers try to see, observe, feel, live, reflect and evaluate learning activities that take place. The implementation stages of the action research consist of planning, acting, observation, and reflection. To obtain accurate results, the collected data in study were statistically analyzed using the formulas of mean or average.  The result showed that the average value of the first cycle of 66.14 (46.33% while the Cycle II 91.29 (96.43% in the second cycle, it has increased significantly. Referring to the hypothesis that the actions proposed in this class action research, it can be concluded that: there is an increased ability of “service” in volleyball games with “make-a-match” at VII-H grade of SMP Negeri 1 Wonoasri in 2012/2013 academic year.   Keywords

Clima organizacional y la prevalencia del síndrome de Burnout en profesionales de la salud de la red de salud Rimac – SMP-LO 2014

OpenAIRE

Espinoza Monge, David Martín; Obregón Andagua, Margot Sonia

2016-01-01

Esta investigación tiene como objetivo: Describir la relación entre el nivel de clima organizacional y la prevalencia del Síndrome de Burnout en Profesionales de la Salud de la Red de Salud Rimac-SMP-LO 2014. Se aplicó el cuestionario de Clima Organizacional versión 2, validado por el MINSA el 2011, con resolución Ministerial. Y el Maslach Burnout Inventory adaptada al español por Moreno, Oliver y Aragoneses. En el mes de Mayo del 2014 en 119 profesionales de la Salud Red de...

PENGEMBANGAN BAHAN AJAR MATERI ARITMETIKA SOSIAL MENGGUNAKAN KONTEKS BAHAN BAKAR MINYAK DENGAN PENDEKATAN PENDIDIKAN MATEMATIKA REALISTIK INDONESIA DI SMP

Directory of Open Access Journals (Sweden)

Neni Lismareni

2015-05-01

Full Text Available Penelitian ini bertujuan untuk mengetahui peran penggunaan konteks bahan bakar minyak yang dapat membantu siswa memahami konsep pada pembelajaran aritmetika sosial di kelas VII. metode yang digunakan dalam penelitian ini adalah development research yang melibatkan siswa kelas VII SMP Negeri 1 Hulu Sungkai. Harga bahan bakar minyak di pedagang eceran dan di SPBU tepat untuk memahami dan menemukan rumus untung, rugi, persentase untung dan persentase rugi untuk menuju tahap formal yaitu melalui dengan cara siswa berfikir harga bahan bakar minyak yang ada di warung dekat rumah mereka. Hasil dari percobaan pembelajaran menunjukkan bahwa melalui serangkaian aktivitas yang berbasis pengalaman telah membantu meningkatkan pemahaman siswa tentang konsep aritmetika sosial.Kata Kunci: aritmetika sosial, bahan bakar minyak, development research type validation studies DOI: http://dx.doi.org/10.22342/jpm.9.1.2186.48 - 58

Characterization of biofoulants illustrates different membrane fouling mechanisms for aerobic and anaerobic membrane bioreactors

KAUST Repository

Xiong, Yanghui

2015-11-17

This study compares the membrane fouling mechanisms of aerobic (AeMBR) and anaerobic membrane bioreactors (AnMBR) of the same reactor configuration at similar operating conditions. Although both the AeMBR and AnMBR achieved more than 90% COD removal efficiency, the fouling mechanisms were different. Molecular weight (MW) fingerprint profiles showed that a majority of fragments in anaerobic soluble microbial products (SMP) were retained by the membrane and some fragments were present in both SMP and in soluble extracellular polymeric substances (EPS), suggesting that the physical retention of SMP components contributed to the AnMBR membrane fouling. One of the dominant fragments was comprised of glycoliproprotein (size 630-640 kD) and correlated in abundance in AnMBR-EPS with the extent of anaerobic membrane fouling. In contrast, all detected AeMBR-SMP fragments permeated through the membrane. Aerobic SMP and soluble EPS also showed very different fingerprinting profiles. A large amount of adenosine triphosphate was present in the AeMBR-EPS, suggesting that microbial activity arising from certain bacterial populations, such as unclassified Comamonadaceae and unclassified Chitinophagaceae, may play a role in aerobic membrane fouling. This study underlines the differences in fouling mechanisms between AeMBR and AnMBR systems and can be applied to facilitate the development of appropriate fouling control strategies.

Potensi Pengembangan Bahan Ajar: Handout Pada Pembelajaran IPA SMP Berbasis Penelitian Pengaruh Konsentrasi Nutrisi Ab Mix Pada Pertumbuhan Tanaman Bayam (Amaranthus Tricolor L.) Dengan Teknik Hidroponik Sistem Wick

OpenAIRE

Putra, Rayshatico Perdana; Wulandari, Sri; Fauziah, Yuslim

2017-01-01

This study was conducted to determine the effect of nutrient concentrations on plant growth AB Mix the spinach with hydroponic techniques wick system as well as the design for the development of learning handout on SMP IPA in March-May 2016. The study was carried out by two phases: an experiment: the effect of nutrient concentrations AB Mix the spinach plant growth (Amaranthus tricolor L.) with hydroponic techniques and the wick system design stage handout science teaching junior high school....

ANALISIS PENERAPAN 8 STANDAR NASIONAL PENDIDIKAN PADA SMP NEGERI 2 DOLOPO KABUPATEN MADIUN

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Luki Eko Cahyono

2015-10-01

Penelitian ini menggunakan desain penelitian Deskriptif Kualitatif. Jenis penelitian adalah studi kasus. Data yang digunakan adalah data Primer. Teknik pengumpulan data yang digunakan adalah wawancara dan dokumentasi. Teknik keabsahan data adalah Triangulasi Sumber dan teknik analisis data yang digunakan adalah pendekatan Strengths, Weakness, Opportunities, dan Threats (Analisis SWOT. Kesimpulan penelitian ini adalah (1 Hasil analisis Strenght (Kekuatan adalah sekolah sudah merencanakan, melaksanakan dan mengevaluasi sebagian besar indikator dalam pemenuhan Standar Nasional Pendidikan sehingga meningkatkan mutu pendidikan sekolah. (2 Hasil analisis Weakness (kelemahan adalah keterbatasan anggaran dana dan sumber daya manusia baik peserta didik, pendidik, maupun tenaga kependidikan dalam pemenuhan seluruh unsur Standar Nasional Pendidikan. (3 Hasil analisis Opportunities (peluang adalah Pemberian workshop dan pelatihan kepada pendidik dan tenaga kependidikan meningkatkan kualitas pendidikan sekolah, dan perencanaan, pelaksanaan pembiayaan serta evaluasi penganggaran yang baik memberikan dampak positif terhadap semua unsur operasional sekolah maupun sarana prasarana sekolah. (4 Hasil analisis Threats (Tantangan adalah perencanaan, sosialisasi, pelaksanaan dan evaluasi serta tindak lanjut yang tidak dijalankan dengan manajemen yang baik dalam upaya pemenuhan Standar Nasional Pendidikan akan menghambat peningkatan kualitas pendidikan sekolah. (5 Hasil penerapan Standar Nasional Pendidikan pada SMP Negeri 2 Dolopo menggunakan analisis SWOT menunjukkan bahwa Kekuatan lebih besar daripada Kelemahan dan Peluang lebih besar dari Ancaman, yang berarti Standar Nasional Pendidikan telah terpenuhi dan menghasilkan Akreditasi Sekolah nilai A.

Modeling of ultrafast THz interactions in molecular crystals

DEFF Research Database (Denmark)

Pedersen, Pernille Klarskov; Clark, Stewart J.; Jepsen, Peter Uhd

2014-01-01

In this paper we present a numerical study of terahertz pulses interacting with crystals of cesium iodide. We model the molecular dynamics of the cesium iodide crystals with the Density Functional Theory software CASTEP, where ultrafast terahertz pulses are implemented to the CASTEP software...... to interact with molecular crystals. We investigate the molecular dynamics of cesium iodide crystals when interacting with realistic terahertz pulses of field strengths from 0 to 50 MV/cm. We find nonlinearities in the response of the CsI crystals at field strengths higher than 10 MV/cm....

Modeling molecular boiling points using computed interaction energies.

Science.gov (United States)

Peterangelo, Stephen C; Seybold, Paul G

2017-12-20

The noncovalent van der Waals interactions between molecules in liquids are typically described in textbooks as occurring between the total molecular dipoles (permanent, induced, or transient) of the molecules. This notion was tested by examining the boiling points of 67 halogenated hydrocarbon liquids using quantum chemically calculated molecular dipole moments, ionization potentials, and polarizabilities obtained from semi-empirical (AM1 and PM3) and ab initio Hartree-Fock [HF 6-31G(d), HF 6-311G(d,p)], and density functional theory [B3LYP/6-311G(d,p)] methods. The calculated interaction energies and an empirical measure of hydrogen bonding were employed to model the boiling points of the halocarbons. It was found that only terms related to London dispersion energies and hydrogen bonding proved significant in the regression analyses, and the performances of the models generally improved at higher levels of quantum chemical computation. An empirical estimate for the molecular polarizabilities was also tested, and the best models for the boiling points were obtained using either this empirical polarizability itself or the polarizabilities calculated at the B3LYP/6-311G(d,p) level, along with the hydrogen-bonding parameter. The results suggest that the cohesive forces are more appropriately described as resulting from highly localized interactions rather than interactions between the global molecular dipoles.

Tangible Models and Haptic Representations Aid Learning of Molecular Biology Concepts

Science.gov (United States)

Johannes, Kristen; Powers, Jacklyn; Couper, Lisa; Silberglitt, Matt; Davenport, Jodi

2016-01-01

Can novel 3D models help students develop a deeper understanding of core concepts in molecular biology? We adapted 3D molecular models, developed by scientists, for use in high school science classrooms. The models accurately represent the structural and functional properties of complex DNA and Virus molecules, and provide visual and haptic…

Efektivitas Pembelajaran Matematika melalui Penerapan Model Pembelajaran Kooperatif Tipe Snowball Throwing

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Andi Mulawakkan Firdaus

2016-10-01

Full Text Available [Bahasa]: Penelitian ini merupakan penelitian Eksperimen semu yang bertujuan untuk mendeskripsikan hasil belajar siswa SMP Negeri 13 Makassar yang diajar dengan menggunakan Model Kooperatif Tipe Snowball Throwing dan Metode Ekspositori, serta untuk mengetahui apakah model pembelajaran kooperatif tipe Snowball Throwing efektif digunakan dalam pembelajaran matematika pada siswa kelas VIII SMP Negeri 13 Makassar. Luaran yang akan dihasilkan dari penelitian ini adalah penerapan alternatif pembelajaran yang tidak monoton sehingga dapat meningkatkan hasil belajar matematika siswa dan perangkat pembelajaran (silabus dan RPP yang berorientasi pada pembelajaran koperatif tipe Snowball Throwing. Subjek penelitian dibagi dalam 2 kelompok, yakni kelompok eksperimen yang diajar dengan menggunakan pembelajaran kooperatif tipe Snowball Throwing dan kelompok kontrol yang diajar dengan menggunakan metode ekspositori. Setiap kelompok diajar dengan frekuensi pertemuan yang sama dengan materi yang sama. Hasil penelitian menunjukan bahwa penerapan model pembelajaran kooperatif tipe Snowball Throwing lebih efektif jika dibandingkan dengan penerapan metode ekspositori untuk pokok bahasan sistem persamaan linear dua variabel. [English]: This experiment research aims to describe the learning outcomes of students at SMP Negeri 13 Makassar taught with snowball throwing (cooperative and expository method and to find out whether snowball throwing method is more effective in learning mathematics than the expository method in grade 7. The results of this research are implementing alternative learning method which is not monotonous to improve students' mathematics learning outcomes and producing learning tools that consist of syllabus and lesson plans based on snowball throwing method in cooperative learning. Research subjects are divided into two groups namely the experimental group taught with snowball throwing and the control group taught with the expository method. Each

Viscoelasticity in Polymers: Phenomenological to Molecular Mathematical Modelling

National Research Council Canada - National Science Library

Banks, H. T; Luke, N. S

2006-01-01

We report on two recent advances in the modelling of viscoelastic polymers: (i) a new constitutive model which combines the virtual stick-slip continuum "molecular-based" ideas of Johnson and Stacer with the Rouse bead chain ideas; (ii...

Molecular modeling of protein materials: case study of elastin

International Nuclear Information System (INIS)

Tarakanova, Anna; Buehler, Markus J

2013-01-01

Molecular modeling of protein materials is a quickly growing area of research that has produced numerous contributions in fields ranging from structural engineering to medicine and biology. We review here the history and methods commonly employed in molecular modeling of protein materials, emphasizing the advantages for using modeling as a complement to experimental work. We then consider a case study of the protein elastin, a critically important ‘mechanical protein’ to exemplify the approach in an area where molecular modeling has made a significant impact. We outline the progression of computational modeling studies that have considerably enhanced our understanding of this important protein which endows elasticity and recoil to the tissues it is found in, including the skin, lungs, arteries and the heart. A vast collection of literature has been directed at studying the structure and function of this protein for over half a century, the first molecular dynamics study of elastin being reported in the 1980s. We review the pivotal computational works that have considerably enhanced our fundamental understanding of elastin's atomistic structure and its extraordinary qualities—focusing on two in particular: elastin's superb elasticity and the inverse temperature transition—the remarkable ability of elastin to take on a more structured conformation at higher temperatures, suggesting its effectiveness as a biomolecular switch. Our hope is to showcase these methods as both complementary and enriching to experimental approaches that have thus far dominated the study of most protein-based materials. (topical review)

EVALUASI PROGRAM PEMBELAJARAN IPA SMP MENGGUNAKAN MODEL COUNTENANCE STAKE

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Astin Lukum

2015-06-01

THE EVALUATION OF SCIENCE TEACHING ON JUNIOR HIGH SCHOOL USING STAKE’S COUNTENANCE MODEL Abstract The purpose of the study was to describe the science learning program on junior high school in Bone Bolanga district based on the Regulation of Minister of Education and Culture of the Republic of Indonesia, Number 65 of 2013 about Processing Standard of Primary and Secondary Education. This study used Stake’s Countanance evaluation model. The data were collected using observation, interview and documentation techniques. The conclusion was: (1 the planning of science learning was categorized fair (68%, it was found that lesson plan was not in accordance with the learning processing standard. (2 The implementation of science learning was categorized fair (57%, that unconformitted with learning processing implementation standard. (3 Student learning outcomes have not met the completeness of minimum criteria (KKM that categorized enough (65% and (4 There were the contingency of planing learning proces and outcome. Keywords: Program Evaluation, Stake's Countenance, Science Learning

A fermionic molecular dynamics technique to model nuclear matter

International Nuclear Information System (INIS)

Vantournhout, K.; Jachowicz, N.; Ryckebusch, J.

2009-01-01

Full text: At sub-nuclear densities of about 10 14 g/cm 3 , nuclear matter arranges itself in a variety of complex shapes. This can be the case in the crust of neutron stars and in core-collapse supernovae. These slab like and rod like structures, designated as nuclear pasta, have been modelled with classical molecular dynamics techniques. We present a technique, based on fermionic molecular dynamics, to model nuclear matter at sub-nuclear densities in a semi classical framework. The dynamical evolution of an antisymmetric ground state is described making the assumption of periodic boundary conditions. Adding the concepts of antisymmetry, spin and probability distributions to classical molecular dynamics, brings the dynamical description of nuclear matter to a quantum mechanical level. Applications of this model vary from investigation of macroscopic observables and the equation of state to the study of fundamental interactions on the microscopic structure of the matter. (author)

MODEL PERANGKAT PEMBELAJARAN MENULIS BERDASARKAN PENDEKATAN PROSES GENRE BAGI SISWA SMP

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Kastam Syamsi

2013-01-01

writing based on the genre process approach for junior high school students. The procedure employed the R2D2 model, consisting of three main stages, i.e. (1 definition, (2 design and development, and (3 dissemination. The data consisted of qualitative and quantitative data. The qualitative data were analyzed using the domain analysis technique with critical and reflective principles, while the quantitative data were analyzed using t-test with SPSS 16.0 for Windows. The study produces five models, i.e.: (1 a syllabus model, (2 a lesson plan model, (3 a learning materials model, (4 an evaluation instrument model, and (5 a teacher guide model of the teaching of writing. Based on the data analysis, the five models of teaching kits for writing are effective to improve the students’ writing ability.

Quantitative separation of the influence of hydrogen bonding of ethanol/water mixture on the shape recovery behavior of polyurethane shape memory polymer

International Nuclear Information System (INIS)

Lu, Haibao; Leng, Jinsong; Min Huang, Wei; Fu, Y Q

2014-01-01

A thermally responsive polyurethane shape memory polymer (SMP) can be actuated in water through a hydrogen bonding interaction between water and the SMP. In this work, we present a comprehensive approach to quantify the hydrogen bonding on the shape recovery behavior of a polyurethane SMP. The stimuli response to the hydrogen bonding of the polyurethane SMP was investigated in ethanol/water mixtures by varying the water content. It was found that depending on the water content, the SMP features a critical hydrogen bonding strength associated with its shape recovery behavior. The Hildebrand solubility parameter theory was employed to quantitatively identify and separate the hydrogen bonding effect of the ethanol/water mixture on the shape recovery ratio and the time. Furthermore, a phenomenological model was developed to predict the glass transition temperature and the shape recovery time of a polyurethane SMP and was verified by the available experimental results. (paper)

Perilaku Bullying dan Peranan Guru BK/Konselor dalam Pengentasannya (Studi Deskriptif terhadap Siswa SMP Negeri 3 Lubuk Basung

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Ilfajri Yenes

2016-06-01

Full Text Available Bullying merupakan suatu situasi di mana terjadinya penyalahgunaan kekuatan/kekuasaan yang dilakukan oleh seseorang/kelompok. Perilaku bullying merupakan  salah satu bentuk kekerasan dan agresif siswa di sekolah. Penelitian ini adalah penelitian deskriptif yang bertujuan untuk mendeskripsikan perilaku bullying yang ditampilkan siswa SMPN 3 Lubuk Basung dan peranan guru BK/konselor dalam pengentasannya. Populasi penelitian adalah siswa di SMP Negeri 3 Lubuk Basung berjumlah  564 orang dengan sampel 138 orang diambil dengan menggunakan teknik propotonal stratified random. Teknik pengumpulan data dengan menggunakan angket. Temuan penelitian menunjukkan bahwa jenis perilaku bullying yang dominan terjadi yaitu menyakiti secara verbal dilanjutkan dengan menyakiti secara fisik kemudian menyakiti secara mental dengan faktor keluarga. Faktor teman sebaya merupakan faktor yang lebih dominan sebagai penyebab perilaku bullying siswa. Secara umum guru BK/konselor cukup berperan mengatasi perilaku bullyingdengan memberikan  layanan informasi sebagai layanan yang lebih dominan diberikan dilanjutkan dengan layanan bimbingan kelompok dan konseling kelompok serta pemberian layanan konseling individual.

(4,0) supersymmetric sigma-model and t-duality

International Nuclear Information System (INIS)

Lhallabi, T.

1997-08-01

The conserved supercurrents J ++ and J -- are deduced for the (4,0) supersymmetric sigma model on harmonic superspace with arbitrary background gauge connection. These are introduced in the Lagrangian density of the model by their couplings to the analytic gauge superfields Γ -- and Γ ++ . The T-duality transformations are obtained by integrating out the analytic gauge superfields. Finally the (4,0) supersymmetric anomaly is derived. (author). 20 refs

Three stage maturity model in SME’s toward industry 4.0

Energy Technology Data Exchange (ETDEWEB)

Ganzarain, J.; Errasti, N.

2016-07-01

To address the challenges regarding the concept of Industry 4.0 and the diversification methodology and based on the strategic guidance towards Industry 4.0, we propose a process model as a guiding framework for Industry 4.0 collaborative diversification vision, strategy and action building. In this paper we suggest a stage process model to guide and train companies to identify new opportunities for diversification within Industry 4.0. Systematically carrying out the stages will take a company to their individual specific vision and collaborative vision between different companies in the Industry 4.0 scenario. Design/methodology/approach: This new collaborative diversification methodology involves industry within the pilot program; from the diversification and capacity assessment analysis of the companys profile, skills and technologies that dominates, to identify the diversification opportunity map and its business modeling within the Industry 4.0 paradigm. Findings: The application of maturity models to the Industry 4.0 may help organizations to integrate this methodology into their culture. Results show a real need for guided support in developing a company-specific Industry 4.0 vision and specific project planning. Originality/value: Industry 4.0 promotes a vision where recent developments in information technology are expected to enable entirely new forms of cooperative engineering and manufacturing. The vision of industry 4.0 describes a whole new approach to business operations, and especially the production industries. To address the challenges regarding the concept of Industry 4.0 and the diversification methodology discussed above, and based on the strategic guidance towards Industry 4.0, we propose a unique process model as a guiding framework for Industry 4.0 collaborative diversification vision, strategy and action building.

Three stage maturity model in SME’s toward industry 4.0

International Nuclear Information System (INIS)

Ganzarain, J.; Errasti, N.

2016-01-01

To address the challenges regarding the concept of Industry 4.0 and the diversification methodology and based on the strategic guidance towards Industry 4.0, we propose a process model as a guiding framework for Industry 4.0 collaborative diversification vision, strategy and action building. In this paper we suggest a stage process model to guide and train companies to identify new opportunities for diversification within Industry 4.0. Systematically carrying out the stages will take a company to their individual specific vision and collaborative vision between different companies in the Industry 4.0 scenario. Design/methodology/approach: This new collaborative diversification methodology involves industry within the pilot program; from the diversification and capacity assessment analysis of the companys profile, skills and technologies that dominates, to identify the diversification opportunity map and its business modeling within the Industry 4.0 paradigm. Findings: The application of maturity models to the Industry 4.0 may help organizations to integrate this methodology into their culture. Results show a real need for guided support in developing a company-specific Industry 4.0 vision and specific project planning. Originality/value: Industry 4.0 promotes a vision where recent developments in information technology are expected to enable entirely new forms of cooperative engineering and manufacturing. The vision of industry 4.0 describes a whole new approach to business operations, and especially the production industries. To address the challenges regarding the concept of Industry 4.0 and the diversification methodology discussed above, and based on the strategic guidance towards Industry 4.0, we propose a unique process model as a guiding framework for Industry 4.0 collaborative diversification vision, strategy and action building.

PENGEMBANGAN MODEL PEMBELAJARAN FISIKA UNTUK MENINGKATKAN KARAKTER ILMIAH SISWA SMP

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Muhammad Agus Martawijaya

2015-06-01

Full Text Available  ABSTRACTIndonesia is experiencing a crisis that led to the occurrence of horizontal conflicts among its citizens. This crisis is an indication that the characters of Indonesian people declined and deviated from the appreciation and the practice of Pancasila’s values as a foundation of the Republic of Indonesia (RI. To overcome this problem, the local wisdom as a cultural element must be integrated into learning process to enhance the scientific characters of students such as honesty. This is a steering normative for character education in schools or educational unit. A’bulo sibatang is one of the local wisdom which still exists and upheld in Barrang Lompo Island’s community and a rudimentary foundation to build a model of learning based on local wisdom. Learning physics model based on this local wisdom met the criteria of validity and practicality, and was found to increase the scientific honesty of students effectively. This model can be applied to any other place in accordance with the characteristics of the study site, the subject of research, and the educators who will become educator’s model.

THE EFFECT OF USING FLASH CARD AND PICTURE STORY IN VOCABULARY MASTERY TO THE SEVENTH GRADER OF SMP PGRI 1 MARGATIGA

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Khoirul Hidayat -

2017-05-01

Full Text Available Based on the content standard, junior high school students are hoped to master vocabulary about 1000 words, so they can understand the conversation. But it fact, most of the students in junior high school do not master vocabulary well. So, the teacher should be able to choose a good media to help students to increase their vocabulary. In this case, flash card with picture story is two of media that can be used to transfer vocabulary material for the students.   The objective of this research is to find the significant differences of using flash card with picture story in vocabulary, and to find which medium is more effective to use as media in vocabulary. This research was true experiment design. Pre test and post test were use to collect the data. There are two problems of the study, (1 are there any significant differences between flash card with picture story in vocabulary mastery for the seventh grade students in SMP PGRI 2 Margatiga academic years 2013/2014?, (2 which one is more effective media in vocabulary learning process, is it flash card or picture story at seventh grade of SMP PGRI 2 Margatiga, academic years 2013/2014?. As a source of data, the researcher utilized flash card with picture story to teach vocabulary for the students. The media help students to learn vocabulary easier and more interesting to understand the subject, so their vocabulary would increase.   The result of the research, it was found that the mean score of picture story in pre test is 53,86, in treatment is 81, and in post test 85,33. Meanwhile the mean score of the flash card media in pre test 59,33, in treatment is 73,5, and in post test is 80,66. It means that the student’s vocabulary has increased, and there is significant difference of using picture story and flash card in vocabulary instruction, and picture story was more effective to use in vocabulary instruction.

The emerging role of cloud computing in molecular modelling.

Science.gov (United States)

Ebejer, Jean-Paul; Fulle, Simone; Morris, Garrett M; Finn, Paul W

2013-07-01

There is a growing recognition of the importance of cloud computing for large-scale and data-intensive applications. The distinguishing features of cloud computing and their relationship to other distributed computing paradigms are described, as are the strengths and weaknesses of the approach. We review the use made to date of cloud computing for molecular modelling projects and the availability of front ends for molecular modelling applications. Although the use of cloud computing technologies for molecular modelling is still in its infancy, we demonstrate its potential by presenting several case studies. Rapid growth can be expected as more applications become available and costs continue to fall; cloud computing can make a major contribution not just in terms of the availability of on-demand computing power, but could also spur innovation in the development of novel approaches that utilize that capacity in more effective ways. Copyright © 2013 Elsevier Inc. All rights reserved.

Negative soil moisture-precipitation feedback in dry and wet regions.

Science.gov (United States)

Yang, Lingbin; Sun, Guoqing; Zhi, Lu; Zhao, Jianjun

2018-03-05

Soil moisture-precipitation (SM-P) feedback significantly influences the terrestrial water and energy cycles. However, the sign of the feedback and the associated physical mechanism have been debated, leaving a research gap regarding global water and climate changes. Based on Koster's framework, we estimate SM-P feedback using satellite remote sensing and ground observation data sets. Methodologically, the sign of the feedback is identified by the correlation between monthly soil moisture and next-month precipitation. The physical mechanism is investigated through coupling precipitation and soil moisture (P-SM), soil moisture ad evapotranspiration (SM-E) and evapotranspiration and precipitation (E-P) correlations. Our results demonstrate that although positive SM-P feedback is predominant over land, non-negligible negative feedback occurs in dry and wet regions. Specifically, 43.75% and 40.16% of the negative feedback occurs in the arid and humid climate zones. Physically, negative SM-P feedback depends on the SM-E correlation. In dry regions, evapotranspiration change is soil moisture limited. In wet regions, evapotranspiration change is energy limited. We conclude that the complex SM-E correlation results in negative SM-P feedback in dry and wet regions, and the cause varies based on the environmental and climatic conditions.

Spherical convolutions and their application in molecular modelling

DEFF Research Database (Denmark)

Boomsma, Wouter; Frellsen, Jes

2017-01-01

Convolutional neural networks are increasingly used outside the domain of image analysis, in particular in various areas of the natural sciences concerned with spatial data. Such networks often work out-of-the box, and in some cases entire model architectures from image analysis can be carried over...... to other problem domains almost unaltered. Unfortunately, this convenience does not trivially extend to data in non-euclidean spaces, such as spherical data. In this paper, we introduce two strategies for conducting convolutions on the sphere, using either a spherical-polar grid or a grid based...... of spherical convolutions in the context of molecular modelling, by considering structural environments within proteins. We show that the models are capable of learning non-trivial functions in these molecular environments, and that our spherical convolutions generally outperform standard 3D convolutions...

PENERAPAN MODEL STAD DENGAN MEDIA DIGITAL WORD SQUARE UNTUK MENINGKATKAN PENGUASAAN KONSEP PADA KOMPETENSI DASAR UANG DAN LEMBAGA KEUANGAN

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Taryadi Taryadi

2013-06-01

Full Text Available The Economics learning in SMP Nasima Semarang did not use an approach which involved students’ roles and potencies. Thus, it needs the STAD (Student Teams Achievement Division learning model and Digital Word Square technique through class action research to solve the problem. The data showed that students’ activities such as motivation and activeness on the 1st cycle and 2nd cycle increased significantly. Whereas, the average of evaluation test result on the 1st cycle was 6.00 and rose to 8.57 on the 2nd cycle. It increased up to 29.98%. Based on the data above, It can be seen that the STAD learning model and DigitalWord Square technique was effective to improve students’ competencies to understand the concept of Money and Banks for the 9th Grade of SMP Nasima’s Students in the academic year of 2011/2012.

PENERAPAN METODE ROLE PLAYING PADA STANDAR KOMPETENSI MEMAHAMI KEGIATAN PELAKU EKONOMI DI MASYARAKAT MATA PELAJARAN IPS EKONOMI SEBAGAI UPAYA PENINGKATAN HASIL BELAJAR SISWA SMP 4 KUDUS

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Muhamad Nukha Murtadlo

2012-06-01

Full Text Available Tujuan dalam penelitian tindakan kelas ini adalah:untuk mengetahui pelaksanaan pembelajaran dengan metode role playing pada standar kompetensi memahami kegiatan pelaku ekonomi di masyarakat mata pelajaran IPS ekonomi siswa kelas VIII SMP Negeri 4 Kudus dapat meningkatkan aktifitas dan hasil belajar siswa. Pengumpulan data menggunakan metode role playing. Hasil penelitian ini menunjukkan bahwa diperoleh rata-rata hasil belajar siswa pada pre-test sebesar 44 dengan ketuntasan klasikal 0%. Siklus I pertemuan pertama sebesar 69 dengan ketuntasan klasikal 34%. Rata-rata hasil belajar siswa pada siklus I pertemuan kedua sebesar 79 dengan ketuntasan klasikal 66%. Kemudian memasuki siklus II pertemuan pertama rata-rata hasil belajar siswa meningkat menjadi 80 dengan ketuntasan klasikal 71%. Siklus II pertemuan kedua rata-rata hasil belajar siswa 82 dan ketuntasan klasikal 87%. Melalui penerapan metode role playing terjadi peningkatan hasil belajar siswa kelas VIII-H SMP 4 Kudus pada mata pelajaran IPS ekonomi standar kompetensi memahami kegiatan pelaku ekonomi di masyarakat. Saran yang berkaitan dengan hasil penelitian ini yaitu: guru hendaknya membimbing siswa dalam memerankan peran agar siswa dapat secara mantap dalam bermain peran dan siswa dapat memahami alur dan makna yang terkandung dalam materi yang disampaikan. � The purpose of this class action in this study were: to know the implementation of learning with role-playing methods in the standard of competence to understand the activities of economic actors in the economic social studies class VIII students of SMP Negeri 4 Ghost can increase the activity and student learning outcomes. Data collection using role playing. The results obtained show that the average student learning outcomes in the pre-test at 44 with a classical completeness 0%. I cycle 69 with the first meeting of the classical 34% completeness. Average student learning outcomes at the second meeting I cycle at 79 with a classical

KEEFEKTIFAN PEMBELAJARAN KOOPERATIF MODEL MIND MAPPING BERBANTUAN CD PEMBELAJARAN TERHADAP HASIL BELAJAR

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Ratri Rahayu

2012-06-01

Full Text Available Abstract Tujuan penelitian ini adalah untuk mengetahui keefektifan pembelajaran kooperatif model mind mapping berbantuan CD pembelajaran terhadaphasil belajar peserta didik kelas VIII SMP Negeri 2 Semarang tahun pelajaran 2011/2012. Populasi dalam penelitian ini adalah peserta didik kelas VIII SMP Negeri 2 Semarang tahun pelajaran 2011/2012 yang berada dalam enam kelas. Sampel diambil secara random sampling. Metode pengumpulan data yang digunakan adalah dengan metode dokumentasi dan tes. Hasil penelitian menunjukkan rata-rata hasil belajar matematika dengan pembelajaran mind mapping berbantuan CD pembelajaran lebih baik dari rata-rata hasil belajar matematika dengan pembelajaran direct instruction, hasil belajar peserta didik mencapai KKM, dan proporsi hasil belajar peserta didik yang diajar dengan pembelajaran mind mapping berbantuan CD pembelajaran yang telah memenuhi KKM lebih baik daripada proporsi hasil belajar peserta didik yang diajar dengan pembelajaran direct instruction. Simpulan yang diperoleh dalam penelitian ini adalah pembelajaran mind mapping berbantuan CD pembelajaran lebih efektif daripada pembelajaran matematika dengan direct instruction untuk meningkatkan hasil belajar peserta didik kelas VIII pada materi pokok teorema Pythagoras. The purpose of this study was to determine the effectiveness of cooperative learning model of mind mapping assisted CD learning againts learning outcomes class VIII students of SMP Negeri 2 Semarang school year 2011/2012. The population in this study is class VIII students of SMP Negeri 2 Semarang school year 2011/2012 which is in six classes. Samples were taken by random sampling. Data collection methods used are the methods of documentation and tests. The results show the average results of math learning with mind mapping learning assisted CD learning is better than average learning outcomes of learning mathematics with direct instruction, student learning outcomes achieved KKM, and the proportion

Molecular Dynamics Simulations of Kinetic Models for Chiral Dominance in Soft Condensed Matter

DEFF Research Database (Denmark)

Toxvaerd, Søren

2001-01-01

Molecular dynamics simulation, models for isomerization kinetics, origin of biomolecular chirality......Molecular dynamics simulation, models for isomerization kinetics, origin of biomolecular chirality...

Observational Constraints for Modeling Diffuse Molecular Clouds

Science.gov (United States)

Federman, S. R.

2014-02-01

Ground-based and space-borne observations of diffuse molecular clouds suggest a number of areas where further improvements to modeling efforts is warranted. I will highlight those that have the widest applicability. The range in CO fractionation caused by selective isotope photodissociation, in particular the large 12C16O/13C16O ratios observed toward stars in Ophiuchus, is not reproduced well by current models. Our ongoing laboratory measurements of oscillator strengths and predissociation rates for Rydberg transitions in CO isotopologues may help clarify the situtation. The CH+ abundance continues to draw attention. Small scale structure seen toward ζ Per may provide additional constraints on the possible synthesis routes. The connection between results from optical transitions and those from radio and sub-millimeter wave transitions requires further effort. A study of OH+ and OH toward background stars reveals that these species favor different environments. This brings to focus the need to model each cloud along the line of sight separately, and to allow the physical conditions to vary within an individual cloud, in order to gain further insight into the chemistry. Now that an extensive set of data on molecular excitation is available, the models should seek to reproduce these data to place further constraints on the modeling results.

Variational methods in molecular modeling

CERN Document Server

2017-01-01

This book presents tutorial overviews for many applications of variational methods to molecular modeling. Topics discussed include the Gibbs-Bogoliubov-Feynman variational principle, square-gradient models, classical density functional theories, self-consistent-field theories, phase-field methods, Ginzburg-Landau and Helfrich-type phenomenological models, dynamical density functional theory, and variational Monte Carlo methods. Illustrative examples are given to facilitate understanding of the basic concepts and quantitative prediction of the properties and rich behavior of diverse many-body systems ranging from inhomogeneous fluids, electrolytes and ionic liquids in micropores, colloidal dispersions, liquid crystals, polymer blends, lipid membranes, microemulsions, magnetic materials and high-temperature superconductors. All chapters are written by leading experts in the field and illustrated with tutorial examples for their practical applications to specific subjects. With emphasis placed on physical unders...

Melting behavior of a model molecular crystalline GeI4

International Nuclear Information System (INIS)

Fuchizaki, Kazuhiro; Asano, Yuta

2015-01-01

A model molecular crystalline GeI 4 was examined using molecular dynamics simulation. The model was constructed in such a way that rigid tetrahedral molecules interact with each other via Lennard-Jones potentials whose centers are located at the vertices of a tetrahedron. Because no other interaction that can “soften” the intermolecular interaction was introduced, the melting curve of the model crystalline material does not exhibit the anomaly that was found for the real substance. However, the current investigation is useful in that it could settle the upper bound of pressure below which the model can predict properties of the molecular liquid. Moreover, singularity-free nature of the melting curve allowed us to analytically treat the melting curve in the light of the Kumari-Dass-Kechin equation. As a result, we could definitely conclude that the well-known Simon equation for the melting curve is merely an approximate expression. The condition for the validity of Simon’s equation was identified. (author)

KELEKATAN ANAK DENGAN IBU DAN AYAH SERTA PERILAKU PORNOGRAFI PADA ANAK USIA SMP

Directory of Open Access Journals (Sweden)

Rika Hardani Hardani

2017-08-01

Full Text Available The mother’s attachment and father’s attachment with children were formed since childhood, will influence the future development of the child's personality. A good personality will make children able to choose good behavior and not to fall into negative behaviors such as behavioral pornography. The research aimed is to analyze the influence of mother-child's attachment and father-child’s attachment on the behavior of school-age child pornography (SMP. The choice of location was purposively in South Tangerang City. A total of 600 children aged junior consisting of 278 men and 322 women were selected using cluster random sampling technique with the class as a cluster of selected schools in the study sites. Respondents were asked to fill out questionnaires of the Inventory of Parent and Peer Attachment (IPPA and the questionnaire Pornography Behavior. Data were analyzed with descriptive analysis, correlation, and regression. The results showed that the boys and girls of mother’s attachment score higher than father’s attachment scores. Behavior pornography on boys is higher than girls. The mother’s attachment and father’s attachment showed a significant negative correlation with the behavior of pornography. Regression analysis showed that family income significant positive effect on the behavior of pornography. Instead, the mother’s attachment and father’s attachment significant negative effect on the behavior of pornography.

PEMBELAJARAN BERBASIS MASALAH UNTUK MENINGKATKAN PEMAHAMAN KONSEP MATEMATIKA PADA MATERI SEGIEMPAT SISWA SMP

Directory of Open Access Journals (Sweden)

Muh Fitrah

2017-04-01

Full Text Available Penelitian ini bertujuan untuk menjelaskan aktivitas guru dan siswa pada pembelajaran berbasis masalah yang dapat meningkatkan pemahaman konsep siswa dan peningkatan pemahaman konsep siswa pada konsep matematika materi segiempat serta respon siswa pada pembelajaran berbasis masalah. Penelitian ini menggunakan penelitian tindakan kelas bersifat kualitatif dan kuantitatif. Subjek penelitian adalah siswa SMP Negeri 1 Dompu Kelas VIIA sebanyak 34 Orang. Instrumen yang digunakan adalah lembar tes, observasi dan wawancara, angket serta dokemen. Data penelitian inipun dianalisis dalam bentuk rata-rata dan persentase kemudian dikombinasikan dengan hasil wawancara yang bersumber dari guru dan siswa. Hasil penelitian menunjukkan bahwa pemahaman konsep siswa dapat ditingkatkan menggunakan pembelajaran berbasis masalah, terbukti pada peningkatan setiap siklus pembelajaran. Hal ini didukung pada aktivitas guru dan siswa berdasarkan langkah-langkah pada pembelajaran berbasis masalah yaitu pada siklus pertama aktivitas guru dengan presentasenya 92,5% meningkat disiklus kedua sebesar 97,5%, sedangkan aktivitas siswa disiklus pertama dengan presentasenya adalah 93,8% dan meningkat pada siklus kedua sebesar 97,69%. Sedangkan pada hasil tes pemahaman konsepnya adalah pada siklus pertama adalah 79, 41% dengan rata-rata nilainya adalah 77,35 dan pada siklus kedua pemahaman konsep matematika siswa meningkat secara signifikan, hal ini terbukti presentasenya adalah 88,24% dengan rata-rata nilainya adalah 84,26. Sehingga pencapaian antara aktivitas guru dan siswa serta pemahaman konsep matematika siswa pada pembelajaran berbasis masalah mendapatkan respon yang positif berdasarkan transkripsi dari siswa, karena siswa merasa senang dengan suasana belajar yang memaksimalkan aktivitas pada kelompok yang dibagikan.

Quantum Mechanics/Molecular Mechanics Modeling of Drug Metabolism

DEFF Research Database (Denmark)

Lonsdale, Richard; Fort, Rachel M; Rydberg, Patrik

2016-01-01

)-mexiletine in CYP1A2 with hybrid quantum mechanics/molecular mechanics (QM/MM) methods, providing a more detailed and realistic model. Multiple reaction barriers have been calculated at the QM(B3LYP-D)/MM(CHARMM27) level for the direct N-oxidation and H-abstraction/rebound mechanisms. Our calculated barriers......The mechanism of cytochrome P450(CYP)-catalyzed hydroxylation of primary amines is currently unclear and is relevant to drug metabolism; previous small model calculations have suggested two possible mechanisms: direct N-oxidation and H-abstraction/rebound. We have modeled the N-hydroxylation of (R...... indicate that the direct N-oxidation mechanism is preferred and proceeds via the doublet spin state of Compound I. Molecular dynamics simulations indicate that the presence of an ordered water molecule in the active site assists in the binding of mexiletine in the active site...

Diamond-like nanoparticles influence on flavonoids transport: molecular modelling

Science.gov (United States)

Plastun, Inna L.; Agandeeva, Ksenia E.; Bokarev, Andrey N.; Zenkin, Nikita S.

2017-03-01

Intermolecular interaction of diamond-like nanoparticles and flavonoids is investigated by numerical simulation. Using molecular modelling by the density functional theory method, we analyze hydrogen bonds formation and their influence on IR - spectra and structure of molecular complex which is formed due to interaction between flavonoids and nanodiamonds surrounded with carboxylic groups. Enriched adamantane (1,3,5,7 - adamantanetetracarboxylic acid) is used as an example of diamond-like nanoparticles. Intermolecular forces and structure of hydrogen bonds are investigated. IR - spectra and structure parameters of quercetin - adamantanetetracarboxylic acid molecular complex are obtained by numerical simulation using the Gaussian software complex. Received data coincide well with experimental results. Intermolecular interactions and hydrogen bonding structure in the obtained molecular complex are examined. Possibilities of flavonoids interaction with DNA at the molecular level are also considered.

High-fertility phenotypes: two outbred mouse models exhibit substantially different molecular and physiological strategies warranting improved fertility.

Science.gov (United States)

Langhammer, Martina; Michaelis, Marten; Hoeflich, Andreas; Sobczak, Alexander; Schoen, Jennifer; Weitzel, Joachim M

2014-01-01

Animal models are valuable tools in fertility research. Worldwide, there are more than 400 transgenic or knockout mouse models available showing a reproductive phenotype; almost all of them exhibit an infertile or at least subfertile phenotype. By contrast, animal models revealing an improved fertility phenotype are barely described. This article summarizes data on two outbred mouse models exhibiting a 'high-fertility' phenotype. These mouse lines were generated via selection over a time period of more than 40 years and 161 generations. During this selection period, the number of offspring per litter and the total birth weight of the entire litter nearly doubled. Concomitantly with the increased fertility phenotype, several endocrine parameters (e.g. serum testosterone concentrations in male animals), physiological parameters (e.g. body weight, accelerated puberty, and life expectancy), and behavioral parameters (e.g. behavior in an open field and endurance fitness on a treadmill) were altered. We demonstrate that the two independently bred high-fertility mouse lines warranted their improved fertility phenotype using different molecular and physiological strategies. The fertility lines display female- as well as male-specific characteristics. These genetically heterogeneous mouse models provide new insights into molecular and cellular mechanisms that enhance fertility. In view of decreasing fertility in men, these models will therefore be a precious information source for human reproductive medicine. Translated abstract A German translation of abstract is freely available at http://www.reproduction-online.org/content/147/4/427/suppl/DC1.

PENINGKATAN PENGETAHUAN TENTANG SEJARAH BAGI SISWA SMP NEGERI 2 KELAPA DUA TANGERANG MELALUI WISATA EDUKASI

Directory of Open Access Journals (Sweden)

YUSTISIA KRISTIANA

2015-12-01

Full Text Available Edutourism is a program combining elements of tourist activities with education. Edutourism is expected tobe a means of preserving the culture values and introduce the history and culture of Indonesia. This is becausethe phenomena among the younger generation who are no longer interested in studying history. Sekolah TinggiPariwisata Pelita Harapan, Universitas Pelita Harapan developed educational travel programs catering for studentsof junior high schools to enhance interest in learning history. Students of SMP Negeri 2 Kelapa Dua Tangerangwere selected to attend this edutourism program by visiting Monumen Nasional and Museum Sejarah Jakarta. Thisprogram was conducted on Tuesday, April 17th, 2012 with total participants were 20 students and two teachers.Edutourism program was led by lecturer and guided by students of Travel Industry Management. The studentsand the team from Travel Industry Management were very enthusiastic during the edutourism. Benefits obtainedby the students through this program are (1 improving the understanding about historical sites in Jakarta, (2widening the knowledge about historical sites in Jakarta, and (3 developing the partnership between the SMPNegeri 2 Kelapa Dua Tangerang and Sekolah Tinggi Pariwisata Pelita Harapan, Universitas Pelita Harapan. Theedutourism program is well accepted and effective to increase student’s interest in learning history.Keywords: edutourism, student’s interest in learning history, historical site

Multi-scale modelling of supercapacitors: From molecular simulations to a transmission line model

Science.gov (United States)

Pean, C.; Rotenberg, B.; Simon, P.; Salanne, M.

2016-09-01

We perform molecular dynamics simulations of a typical nanoporous-carbon based supercapacitor. The organic electrolyte consists in 1-ethyl-3-methylimidazolium and hexafluorophosphate ions dissolved in acetonitrile. We simulate systems at equilibrium, for various applied voltages. This allows us to determine the relevant thermodynamic (capacitance) and transport (in-pore resistivities) properties. These quantities are then injected in a transmission line model for testing its ability to predict the charging properties of the device. The results from this macroscopic model are in good agreement with non-equilibrium molecular dynamics simulations, which validates its use for interpreting electrochemical impedance experiments.

Grid computing in large pharmaceutical molecular modeling.

Science.gov (United States)

Claus, Brian L; Johnson, Stephen R

2008-07-01

Most major pharmaceutical companies have employed grid computing to expand their compute resources with the intention of minimizing additional financial expenditure. Historically, one of the issues restricting widespread utilization of the grid resources in molecular modeling is the limited set of suitable applications amenable to coarse-grained parallelization. Recent advances in grid infrastructure technology coupled with advances in application research and redesign will enable fine-grained parallel problems, such as quantum mechanics and molecular dynamics, which were previously inaccessible to the grid environment. This will enable new science as well as increase resource flexibility to load balance and schedule existing workloads.

Interaction of monomeric Ebola VP40 protein with a plasma membrane: A coarse-grained molecular dynamics (CGMD) simulation study.

Science.gov (United States)

Mohamad Yusoff, Mohamad Ariff; Abdul Hamid, Azzmer Azzar; Mohammad Bunori, Noraslinda; Abd Halim, Khairul Bariyyah

2018-06-01

Ebola virus is a lipid-enveloped filamentous virus that affects human and non-human primates and consists of several types of protein: nucleoprotein, VP30, VP35, L protein, VP40, VP24, and transmembrane glycoprotein. Among the Ebola virus proteins, its matrix protein VP40 is abundantly expressed during infection and plays a number of critical roles in oligomerization, budding and egress from the host cell. VP40 exists predominantly as a monomer at the inner leaflet of the plasma membrane, and has been suggested to interact with negatively charged lipids such as phosphatidylinositol 4,5-bisphosphate (PIP 2 ) and phosphatidylserine (PS) via its cationic patch. The hydrophobic loop at the C-terminal domain has also been shown to be important in the interaction between the VP40 and the membrane. However, details of the molecular mechanisms underpinning their interactions are not fully understood. This study aimed at investigating the effects of mutation in the cationic patch and hydrophobic loop on the interaction between the VP40 monomer and the plasma membrane using coarse-grained molecular dynamics simulation (CGMD). Our simulations revealed that the interaction between VP40 and the plasma membrane is mediated by the cationic patch residues. This led to the clustering of PIP 2 around the protein in the inner leaflet as a result of interactions between some cationic residues including R52, K127, K221, K224, K225, K256, K270, K274, K275 and K279 and PIP 2 lipids via electrostatic interactions. Mutation of the cationic patch or hydrophobic loop amino acids caused the protein to bind at the inner leaflet of the plasma membrane in a different orientation, where no significant clustering of PIP 2 was observed around the mutated protein. This study provides basic understanding of the interaction of the VP40 monomer and its mutants with the plasma membrane. Copyright © 2018 Elsevier Inc. All rights reserved.

12 CFR 40.2 - Model privacy form and examples.

Science.gov (United States)

2010-01-01

... 40.2 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY PRIVACY OF CONSUMER... privacy form in Appendix A of this part, consistent with the instructions in Appendix A, constitutes compliance with the notice content requirements of §§ 40.6 and 40.7 of this part, although use of the model...

Three Stage Maturity Model in SME’s towards Industry 4.0

OpenAIRE

Ganzarain, Jaione; Errasti, Nekane

2016-01-01

Purpose: To address the challenges regarding the concept of Industry 4.0 and the diversification methodology and based on the strategic guidance towards Industry 4.0, we propose a process model as a guiding framework for Industry 4.0 collaborative diversification vision, strategy and action building. In this paper we suggest a stage process model to guide and train companies to identify new opportunities for diversification within Industry 4.0. Systematically carrying out the s...

75 FR 75868 - Airworthiness Directives; Diamond Aircraft Industries GmbH Models DA 40 and DA 40F Airplanes

Science.gov (United States)

2010-12-07

... Airworthiness Directives; Diamond Aircraft Industries GmbH Models DA 40 and DA 40F Airplanes AGENCY: Federal... of the Thielert Engine Owners Group commented that the Model DA 42 has the same door design and the same unsafe condition. He recommended that the AD also apply to the Model DA 42. The FAA has discussed...

40 CFR 194.23 - Models and computer codes.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Models and computer codes. 194.23... General Requirements § 194.23 Models and computer codes. (a) Any compliance application shall include: (1... obtain stable solutions; (iv) Computer models accurately implement the numerical models; i.e., computer...

Cohesion between two clay lamellae: From Primitive Model to Full Molecular Simulation

International Nuclear Information System (INIS)

Carrier, Benoit; Vandamme, Matthieu; Pellenq, Roland; Van Damme, Henri

2012-01-01

Document available in extended abstract form only. The objective of this work is to investigate the range of validity of various models to describe accurately the cohesion between two charged clay lamellae. These models, in order of increasing complexity, are the Derjaguin-Landau-Verwey-Overbeek (DLVO) theory, the primitive model, the explicit solvent primitive model and the full molecular model. We aim at providing a clear picture of which physical mechanisms play a significant role for various interlayer spacings, surface charges and cationic charges. The up-scaling of the mechanical properties starting from the lamellar microstructure of a smectite is usually performed within the framework of the DLVO theory. In this case, the interaction between two charged lamellae with cations between them is the sum of the repulsive double layer electrostatic interaction and of the attractive Van der Waals interaction. However, the Primitive Model shows that concentration fluctuations of counter-ions can generate a strongly attractive ionic correlation force. The Primitive Model is a Monte-Carlo simulation of hydrated counter-ions between two infinite charges surfaces and the water is implicitly modeled by scaling all electrostatic interactions by the dielectric permittivity of bulk water. Nevertheless, for very small inter-layer spacings (1 nm), molecular simulations and experiments show that water is organized in a layered structure and does not behave like bulk water. Therefore, we investigate the role of the solvent in the cohesion of clay lamellae. For this purpose, we use a modified version of the original Primitive Model in which the solvent is modeled by point-dipoles: This model is called the Explicit Solvent Primitive Model. We consider four different systems: A Na + -montmorillonite, a Ca 2+ -montmorillonite, a Na + -vermiculite, a Ca 2+ -vermiculite. The vermiculite layers are twice as charged as the montmorillonite layers. We use a full molecular model as a

Evaluation and intercomparison of three-dimensional global marine carbon cycle models

Energy Technology Data Exchange (ETDEWEB)

Caldeira, K., LLNL

1998-07-01

The addition of carbon dioxide to the atmosphere from fossil fuel burning and deforestation has profound implications for the future of the earth`s climate and hence for humankind itself. Society is looking toward the community of environmental scientists to predict the consequences of increased atmospheric carbon dioxide so that sound input can be provided to economists, environmental engineers, and, ultimately, policy makers. Environmental scientists have responded to this challenge through the creation of several ambitious, highly-coordinated programs, each focused on a different aspect of the climate system. Recognizing that numerical models, be they relatively simple statistical-empirical models or highly complex process-oriented models, are the only means for predicting the future of the climate system, all of these programs include the development of accurate, predictive models as a central goal. The Joint Global Ocean Flux Study (JGOFS) is one such program, and was built on the well-founded premise that biological, chemical and physical oceanographic processes have a profound influence on the C0{sub 2} content of the atmosphere. The, cap-stone, phase of JGOFS, the Synthesis and Modeling Project (SMP), is charged with the development of models that can be used in the prediction of future air-sea partitioning of C0{sub 2}. JGOFS, particularly the SMP phase, has a number of interim goals as well, including the determination of fluxes and inventories of carbon in the modern ocean that air germane to the air-sea partitioning of C0{sub 2}. Models have a role to play here too, because many of these fluxes and inventories, such as the distributions of anthropogenic dissolved inorganic carbon (DIC), new primary production and aphotic zone remineralization, while not amenable to direct observation on the large scale, can be determined using a variety of modeling approaches (Siegenthaler and Oeschger, 1987; Maier-Reimer and Hasselman, 1987, Bacastow and Maier

Advancing NASA’s AirMOSS P-Band Radar Root Zone Soil Moisture Retrieval Algorithm via Incorporation of Richards’ Equation

Directory of Open Access Journals (Sweden)

Morteza Sadeghi

2016-12-01

Full Text Available P-band radar remote sensing applied during the Airborne Microwave Observatory of Subcanopy and Subsurface (AirMOSS mission has shown great potential for estimation of root zone soil moisture. When retrieving the soil moisture profile (SMP from P-band radar observations, a mathematical function describing the vertical moisture distribution is required. Because only a limited number of observations are available, the number of free parameters of the mathematical model must not exceed the number of observed data. For this reason, an empirical quadratic function (second order polynomial is currently applied in the AirMOSS inversion algorithm to retrieve the SMP. The three free parameters of the polynomial are retrieved for each AirMOSS pixel using three backscatter observations (i.e., one frequency at three polarizations of Horizontal-Horizontal, Vertical-Vertical and Horizontal-Vertical. In this paper, a more realistic, physically-based SMP model containing three free parameters is derived, based on a solution to Richards’ equation for unsaturated flow in soils. Evaluation of the new SMP model based on both numerical simulations and measured data revealed that it exhibits greater flexibility for fitting measured and simulated SMPs than the currently applied polynomial. It is also demonstrated that the new SMP model can be reduced to a second order polynomial at the expense of fitting accuracy.

Multiobjective Optimization for Fixture Locating Layout of Sheet Metal Part Using SVR and NSGA-II

Directory of Open Access Journals (Sweden)

Yuan Yang

2017-01-01

Full Text Available Fixture plays a significant role in determining the sheet metal part (SMP spatial position and restraining its excessive deformation in many manufacturing operations. However, it is still a difficult task to design and optimize SMP fixture locating layout at present because there exist multiple conflicting objectives and excessive computational cost of finite element analysis (FEA during the optimization process. To this end, a new multiobjective optimization method for SMP fixture locating layout is proposed in this paper based on the support vector regression (SVR surrogate model and the elitist nondominated sorting genetic algorithm (NSGA-II. By using ABAQUS™ Python script interface, a parametric FEA model is established. And the fixture locating layout is treated as design variables, while the overall deformation and maximum deformation of SMP under external forces are as the multiple objective functions. First, a limited number of training and testing samples are generated by combining Latin hypercube design (LHD with FEA. Second, two SVR prediction models corresponding to the multiple objectives are established by learning from the limited training samples and are integrated as the multiobjective optimization surrogate model. Third, NSGA-II is applied to determine the Pareto optimal solutions of SMP fixture locating layout. Finally, a multiobjective optimization for fixture locating layout of an aircraft fuselage skin case is conducted to illustrate and verify the proposed method.

Real-time intravital imaging of pH variation associated with osteoclast activity.

Science.gov (United States)

Maeda, Hiroki; Kowada, Toshiyuki; Kikuta, Junichi; Furuya, Masayuki; Shirazaki, Mai; Mizukami, Shin; Ishii, Masaru; Kikuchi, Kazuya

2016-08-01

Intravital imaging by two-photon excitation microscopy (TPEM) has been widely used to visualize cell functions. However, small molecular probes (SMPs), commonly used for cell imaging, cannot be simply applied to intravital imaging because of the challenge of delivering them into target tissues, as well as their undesirable physicochemical properties for TPEM imaging. Here, we designed and developed a functional SMP with an active-targeting moiety, higher photostability, and a fluorescence switch and then imaged target cell activity by injecting the SMP into living mice. The combination of the rationally designed SMP with a fluorescent protein as a reporter of cell localization enabled quantitation of osteoclast activity and time-lapse imaging of its in vivo function associated with changes in cell deformation and membrane fluctuations. Real-time imaging revealed heterogenic behaviors of osteoclasts in vivo and provided insights into the mechanism of bone resorption.

Models and algorithms for biomolecules and molecular networks

CERN Document Server

DasGupta, Bhaskar

2016-01-01

By providing expositions to modeling principles, theories, computational solutions, and open problems, this reference presents a full scope on relevant biological phenomena, modeling frameworks, technical challenges, and algorithms. * Up-to-date developments of structures of biomolecules, systems biology, advanced models, and algorithms * Sampling techniques for estimating evolutionary rates and generating molecular structures * Accurate computation of probability landscape of stochastic networks, solving discrete chemical master equations * End-of-chapter exercises

Bayesian semiparametric regression models to characterize molecular evolution

Directory of Open Access Journals (Sweden)

Datta Saheli

2012-10-01

Full Text Available Abstract Background Statistical models and methods that associate changes in the physicochemical properties of amino acids with natural selection at the molecular level typically do not take into account the correlations between such properties. We propose a Bayesian hierarchical regression model with a generalization of the Dirichlet process prior on the distribution of the regression coefficients that describes the relationship between the changes in amino acid distances and natural selection in protein-coding DNA sequence alignments. Results The Bayesian semiparametric approach is illustrated with simulated data and the abalone lysin sperm data. Our method identifies groups of properties which, for this particular dataset, have a similar effect on evolution. The model also provides nonparametric site-specific estimates for the strength of conservation of these properties. Conclusions The model described here is distinguished by its ability to handle a large number of amino acid properties simultaneously, while taking into account that such data can be correlated. The multi-level clustering ability of the model allows for appealing interpretations of the results in terms of properties that are roughly equivalent from the standpoint of molecular evolution.

A Comparative Study of Successful Central Nervous System Drugs Using Molecular Modeling

Science.gov (United States)

Kim, Hyosub; Sulaimon, Segun; Menezes, Sandra; Son, Anne; Menezes, Warren J. C.

2011-01-01

Molecular modeling is a powerful tool used for three-dimensional visualization and for exploring electrostatic forces involved in drug transport. This tool enhances student understanding of structure-property relationships, as well as actively engaging them in class. Molecular modeling of several central nervous system (CNS) drugs is used to…

Applications of Molecular and Materials Modeling

Science.gov (United States)

2002-01-01

Chimica Industriale Molecular modeling of solvation Prof. Jacopo Tomasi http://www.dcci.unipi.it/attivita /attivita.html; http://www.dcci.unipi.it...solutions/ cases/notes/scale.html BNFL Sorption of gases in zeolites Dr. Scott L. Owens http://www.bnfl.co.uk/ BAE (British Aerospace Engineering) Rare...permeation of gases ; adhesion and interfacial interactions of siloxane networks; chemical reactivity and catalysis; environmental and cosmetics

A molecular prognostic model predicts esophageal squamous cell carcinoma prognosis.

Directory of Open Access Journals (Sweden)

Hui-Hui Cao

Full Text Available Esophageal squamous cell carcinoma (ESCC has the highest mortality rates in China. The 5-year survival rate of ESCC remains dismal despite improvements in treatments such as surgical resection and adjuvant chemoradiation, and current clinical staging approaches are limited in their ability to effectively stratify patients for treatment options. The aim of the present study, therefore, was to develop an immunohistochemistry-based prognostic model to improve clinical risk assessment for patients with ESCC.We developed a molecular prognostic model based on the combined expression of axis of epidermal growth factor receptor (EGFR, phosphorylated Specificity protein 1 (p-Sp1, and Fascin proteins. The presence of this prognostic model and associated clinical outcomes were analyzed for 130 formalin-fixed, paraffin-embedded esophageal curative resection specimens (generation dataset and validated using an independent cohort of 185 specimens (validation dataset.The expression of these three genes at the protein level was used to build a molecular prognostic model that was highly predictive of ESCC survival in both generation and validation datasets (P = 0.001. Regression analysis showed that this molecular prognostic model was strongly and independently predictive of overall survival (hazard ratio = 2.358 [95% CI, 1.391-3.996], P = 0.001 in generation dataset; hazard ratio = 1.990 [95% CI, 1.256-3.154], P = 0.003 in validation dataset. Furthermore, the predictive ability of these 3 biomarkers in combination was more robust than that of each individual biomarker.This technically simple immunohistochemistry-based molecular model accurately predicts ESCC patient survival and thus could serve as a complement to current clinical risk stratification approaches.

Molecular modeling used to evaluate CYP2C9-dependent metabolism: homology modeling, molecular dynamics and docking simulations.

Science.gov (United States)

Mendieta-Wejebe, Jessica E; Correa-Basurto, José; García-Segovia, Erika M; Ceballos-Cancino, Gisela; Rosales-Hernández, Martha C

2011-07-01

Cytochrome P450 (CYP) 2C9 is the principal isoform of the CYP2C subfamily in the human liver and is involved in the oxidation of several endogenous and xenobiotic compounds, including many therapeutic drugs. The metabolism of drugs by CYP2C9 can yield either safe or toxic products, which may be related to the recognition and binding modes of the substrates to this isoform. These interactions can be studied using in silico methods such as quantum chemistry, molecular dynamics and docking simulations, which can also be useful for predicting the structure of metabolites. In these types of studies, the ligand and the protein must be tridimensional models; thus, the protein can be built by homology modeling or retrieved from the Protein Data Bank. Therefore, the current review emphasizes the importance of using in silico methods to predict the metabolism of CYP2C9 because these computational tools have allowed the description of the principal characteristics of the active site of this isoform at the molecular level and the chemical properties of its ligands.

Modeling ion sensing in molecular electronics

International Nuclear Information System (INIS)

Chen, Caroline J.; Smeu, Manuel; Ratner, Mark A.

2014-01-01

We examine the ability of molecules to sense ions by measuring the change in molecular conductance in the presence of such charged species. The detection of protons (H + ), alkali metal cations (M + ), calcium ions (Ca 2+ ), and hydronium ions (H 3 O + ) is considered. Density functional theory (DFT) is used within the Keldysh non-equilibrium Green's function framework (NEGF) to model electron transport properties of quinolinedithiol (QDT, C 9 H 7 NS 2 ), bridging Al electrodes. The geometry of the transport region is relaxed with DFT. The transport properties of the device are modeled with NEGF-DFT to determine if this device can distinguish among the M + + QDT species containing monovalent cations, where M + = H + , Li + , Na + , or K + . Because of the asymmetry of QDT in between the two electrodes, both positive and negative biases are considered. The electron transmission function and conductance properties are simulated for electrode biases in the range from −0.5 V to 0.5 V at increments of 0.1 V. Scattering state analysis is used to determine the molecular orbitals that are the main contributors to the peaks in the transmission function near the Fermi level of the electrodes, and current-voltage relationships are obtained. The results show that QDT can be used as a proton detector by measuring transport through it and can conceivably act as a pH sensor in solutions. In addition, QDT may be able to distinguish among different monovalent species. This work suggests an approach to design modern molecular electronic conductance sensors with high sensitivity and specificity using well-established quantum chemistry

Molecular modelling and radiopharmaceutical design

International Nuclear Information System (INIS)

Neves, M.; Gano, L.; Costa, M.C.; Raminhos, H.; Rosado, M.; Fausto, R.

2002-01-01

Aim: Among several headings for radiopharmaceuticals (RPs) design, molecular modelling (MM) could be used for the prediction of ligands and metal-complexes structures. Using MM it is also possible to simulate molecular interactions between predicted structures and specific biomolecules. Bisphosphonates (BPs) are ligands that are able to coordinate radioactive metals, such as 153 Sm, 166 Ho, 186 Re, etc., but they are all polymeric complexes difficult to characterize. It is reported that the bone uptake does not depend on the nature of metal center, but is primarily driven by the nature of the ligand, as in the case of HEDP-M (M= 99m Tc, 186 Re, 113 Sn). So, it would be interesting to estimate the relevant molecular properties of BPs by MM, simulate their interaction with hydroxyapatite (HAP) the main bone component, and then correlate the predicted molecular parameters with experimental data obtained from HAP binding and biodistribution studies of BPs carrying radioactive metals. Materials and Methods: The molecular structures and preferred conformations of BPs differing in the length of the aliphatic chain attached to their substituted amine groups (pami-dronate, olpadronate and ibandronate) were obtained using the second-generation CVFF 950 (version 1.01) force field of Hwang et al. Simulation of the interactions between the studied BPs and HAP were performed using a Cerius-2 system of programs running on a Silicon Graphics O2 workstation. BPs- 153 Sm complexes were synthesized and characterized by ITLC. Their binding to HAP and in vivo biodistribution studies were carried out as usual described in literature. Results: A direct correlation could be established between in vitro BPs affinity towards HAP and their corresponding energies from the Coulomb interactions involving the N and P atoms of the studied BPs bound to the HAP (0,0,1) surface and the nearest Ca atoms of HAP. The BPs- 153 Sm showing the highest binding to HAP and skeletal uptake are those which

PENGARUH DUKUNGAN ORANG TUA DAN FASILITAS BELAJAR DI SEKOLAH TERHADAP PRESTASI BELAJAR EKONOMI MELALUI MOTIVASI BELAJAR SISWA KELAS VIII SMP NEGERI 2 UNGARAN

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M Fathur Rahman

2014-06-01

Full Text Available Penelitian ini bertujuan untuk mengetahui pengaruh dukungan orang tua dan fasilitas belajar di sekolah terhadap prestasi belajar melalui motivasi belajar siswa SMP Negeri 2 Ungaran. Populasi penelitian ini berjumlah 132 siswa dan sampel dalam penelitian ini berjumlah 99 siswa, pengambilan sampel ini menggunakan metode probility simple random sampling. Metode pengumpulan data menggunakan angket dan dokumentasi. Teknik analis data yang digunakan dalam penelitian ini adalah regresi linier dan analisis jalur. Penelitian ini terdiri dari 2 variabel bebas yaitu dukungan orang tua (X1 dan fasilitas belajar (X2, motivasi belajar sebagai intervening (Y1, dengan prestasi belajar (Y sebagai variabel terikat. Hasil penelitian diperoleh persamaan regresi Y1 = 32,466+ 0,264X1 + 0,323X2 + dan Y2 = 41,747 + 0,402X1 + 0,406X2 + 0,45Y1+ . Hasil análisis jalur menunjukkan bahwa terdapat pengaruh langsung (DO-PB, (FB-PB, (MB-PB, dan pengaruh tidak langsung (DO-MB-PB dan (FB-MB-HB. This research aims to determine the effect of namely parental support and learning facilities learning achievement motivation through eighth grade students of SMP Negeri 2 Unggaran. The study population totaled 132 students and the sample in this study is 99 students, this sampling method probility simple random sampling. Methods of data collection using questionnaires and documentation. Engineering data analysts used in this study is a linear regression and path analysis. The study consisted of two independent variables, namely parental support (X1 and learning facilities (X2, motivation to learn as intervening (Y1, the learning achievement (Y as the dependent variable. The results were obtained regression equation Y1 = 32,466+ 0,264X1 + 0,323X2 + dan Y2 = 41,747 + 0,402X1 + 0,406X2 + 0,45Y1+ . The results of path analysis showed that there is a direct effect (DO-PB, (FB-PB, (MB-PB, and the indirect effect (DO-MB-PB and (FB-MB-HB.

Measurements of the Backstreaming Proton IONS in the Self-Magnetic Pinch (SMP) Diode Utilizing Copper Activation Technique

Science.gov (United States)

Mazarakis, Michael; Cuneo, Michael; Fournier, Sean; Johnston, Mark; Kiefer, Mark; Leckbee, Joshua; Simpson, Sean; Renk, Timothy; Webb, Timothy; Bennett, Nichelle

2016-10-01

The results presented here were obtained with an SMP diode mounted at the front high voltage end of the 8-10-MV RITS Self-Magnetically Insulated Transmission Line (MITL) voltage adder. Our experiments had two objectives: first, to measure the contribution of the back-streaming proton currents emitted from the anode target, and second, to evaluate the energy of those ions and hence the actual Anode-Cathode (A-K) gap voltage. The accelerating voltage quoted in the literature is estimated utilizing para-potential flow theories. Thus, it is interesting to have another independent measurement of the A-K voltage. We have measured the back-streaming protons emitted from the anode and propagating through a hollow cathode tip for various diode configurations and different techniques of target cleaning treatment, namely, heating at very high temperatures with DC and pulsed current, with RF plasma cleaning, and with both plasma cleaning and heating. We have also evaluated the A-K gap voltage by energy filtering techniques. Sandia is operated by Sandia Corporation, a subsidiary of Lockheed Martin Company, for the US DOE NNSA under Contract No. DE-AC04-94AL85000.

KEEFEKTIFAN MODEL CONNECTED DAN INTEGRATED DALAM PEMBELAJARAN IPS SMP DI KOTA YOGYAKARTA

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Idrus idrus

2011-01-01

Full Text Available This research aimed to: (1 analyze the differences in social studies learning achievement between the students using connected and integrated models and those using conventional model; and (2 analyze the hierarchy of the effect of the learning models  among the connected, integrated, and conventional. This experimental research employed a matching post-test comparison group design. The population of this research was National Standardized Schools of Junior Secondary Schools in Yogyakarta. The technique used for sample drawing was multistage sampling. In this research, the independent variable was the learning model which consisted of three categories: integrated, connected, and conventional models. The dependent variable was the mean score of students’ learning achievement in social studies subject. Data collection was done by means of an achievement test. Instrument validation was done by discriminating power and difficulty index, while the reliability was calculated by KR-20. The pre-requisite  test included normality and homogeneity tests. The normality test used Kolmogorov-Smirnov and the homogeneity test used Levene Test. Data were analyzed in one way anova analysis and continued with Scheffe comparison test on the significance level of 0.05. The results of the experiment show that there are  significant difference among the students’ learning achievement who used integrated, connected, and conventional models. The continued test using Scheffe ensured that the integrated model was more effective than the connected and conventional models, while the connected model was more effective in improving the students’ learning achievement in social studies subject compared with the conventional model. Therefore, the hierarchy of the effect of the learning models is first the integrated model followed by connected and conventional models. Key words: Connected, Integrated Models, Social Studies Learning

PELATIHAN PLIOMETRIK ALTERNATE LEG BOUND DAN DOUBLE LEG BOUND MENINGKATKAN DAYA LEDAK OTOT TUNGKAI PADA SISWA PUTRA KELAS VII SMP NEGERI 3 SUKAWATI TAHUN PELAJARAN 2012/2013

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Komang Ayu Tri Widhiyanti

2013-11-01

Full Text Available This study was conducted to know the improvement the explosive power of leg muscle. It was done through 5 set 12 repetitions during 6 weeks in the field of SMP Negeri 3 Sukawati started from 4 p.m. until 6 p.m. There were 3 groups applied in this study such as group 1 (control group that was instructed to kick a ball, group 2 (plyometric training of alternate leg bound, and group 3 (plyometric training of double leg bound. The sample was 14 male students who were in the seventh grade class of SMP Negeri 3 Sukawati in the academic year 2012/2013. The data was gained by doing the movement of alternate leg bound and double leg bound that each movement was done three times before and after the training. The hypothesis was examined by using independent t-test with the result 0.05 (p<0.05. Based on the different result of analysis test in each group, the gain score of the group 2 with the group 1 about 0,51 that shows the significant differences p = 0,00, the gain score of the group 2 with the group 3 about 0,31 that shows the significant differences p = 0,00, the gain score of the group 3 with the group 1 about 0,20 that shows the significant differences p = 0,00. Thus, alternate leg bound plyometric training is more effective than double leg bound. It is expected that the coach and the gym teacher to apply alternate leg bound plyometric training as an alternative to improve the explosive power of leg muscle.

The GFDL global atmosphere and land model AM4.0/LM4.0: 2. Model description, sensitivity studies, and tuning strategies

Science.gov (United States)

Zhao, M.; Golaz, J.-C.; Held, I. M.; Guo, H.; Balaji, V.; Benson, R.; Chen, J.-H.; Chen, X.; Donner, L. J.; Dunne, J. P.; Dunne, Krista A.; Durachta, J.; Fan, S.-M.; Freidenreich, S. M.; Garner, S. T.; Ginoux, P.; Harris, L. M.; Horowitz, L. W.; Krasting, J. P.; Langenhorst, A. R.; Liang, Z.; Lin, P.; Lin, S.-J.; Malyshev, S. L.; Mason, E.; Milly, Paul C.D.; Ming, Y.; Naik, V.; Paulot, F.; Paynter, D.; Phillipps, P.; Radhakrishnan, A.; Ramaswamy, V.; Robinson, T.; Schwarzkopf, D.; Seman, C. J.; Shevliakova, E.; Shen, Z.; Shin, H.; Silvers, L.; Wilson, J. R.; Winton, M.; Wittenberg, A. T.; Wyman, B.; Xiang, B.

2018-01-01

In Part 2 of this two‐part paper, documentation is provided of key aspects of a version of the AM4.0/LM4.0 atmosphere/land model that will serve as a base for a new set of climate and Earth system models (CM4 and ESM4) under development at NOAA's Geophysical Fluid Dynamics Laboratory (GFDL). The quality of the simulation in AMIP (Atmospheric Model Intercomparison Project) mode has been provided in Part 1. Part 2 provides documentation of key components and some sensitivities to choices of model formulation and values of parameters, highlighting the convection parameterization and orographic gravity wave drag. The approach taken to tune the model's clouds to observations is a particular focal point. Care is taken to describe the extent to which aerosol effective forcing and Cess sensitivity have been tuned through the model development process, both of which are relevant to the ability of the model to simulate the evolution of temperatures over the last century when coupled to an ocean model.

The GFDL Global Atmosphere and Land Model AM4.0/LM4.0: 2. Model Description, Sensitivity Studies, and Tuning Strategies

Science.gov (United States)

Zhao, M.; Golaz, J.-C.; Held, I. M.; Guo, H.; Balaji, V.; Benson, R.; Chen, J.-H.; Chen, X.; Donner, L. J.; Dunne, J. P.; Dunne, K.; Durachta, J.; Fan, S.-M.; Freidenreich, S. M.; Garner, S. T.; Ginoux, P.; Harris, L. M.; Horowitz, L. W.; Krasting, J. P.; Langenhorst, A. R.; Liang, Z.; Lin, P.; Lin, S.-J.; Malyshev, S. L.; Mason, E.; Milly, P. C. D.; Ming, Y.; Naik, V.; Paulot, F.; Paynter, D.; Phillipps, P.; Radhakrishnan, A.; Ramaswamy, V.; Robinson, T.; Schwarzkopf, D.; Seman, C. J.; Shevliakova, E.; Shen, Z.; Shin, H.; Silvers, L. G.; Wilson, J. R.; Winton, M.; Wittenberg, A. T.; Wyman, B.; Xiang, B.

2018-03-01

In Part 2 of this two-part paper, documentation is provided of key aspects of a version of the AM4.0/LM4.0 atmosphere/land model that will serve as a base for a new set of climate and Earth system models (CM4 and ESM4) under development at NOAA's Geophysical Fluid Dynamics Laboratory (GFDL). The quality of the simulation in AMIP (Atmospheric Model Intercomparison Project) mode has been provided in Part 1. Part 2 provides documentation of key components and some sensitivities to choices of model formulation and values of parameters, highlighting the convection parameterization and orographic gravity wave drag. The approach taken to tune the model's clouds to observations is a particular focal point. Care is taken to describe the extent to which aerosol effective forcing and Cess sensitivity have been tuned through the model development process, both of which are relevant to the ability of the model to simulate the evolution of temperatures over the last century when coupled to an ocean model.

Molecular modeling of fentanyl analogs

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LJILJANA DOSEN-MICOVIC

2004-11-01

Full Text Available Fentanyl is a highly potent and clinically widely used narcotic analgesic. A large number of its analogs have been synthesized, some of which (sufentanil and alfentanyl are also in clinical use. Theoretical studies, in recent years, afforded a better understanding of the structure-activity relationships of this class of opiates and allowed insight into the molecular mechanism of the interactions of fentanyl analogs with their receptors. An overview of the current computational techniques for modeling fentanyl analogs, their receptors and ligand-receptor interactions is presented in this paper.

PENGEMBANGAN INSTRUMEN ASESMEN BERPIKIR KRITIS UNTUK SISWA SMP KELAS VII PADA MATERI INTERAKSI MAKHLUK HIDUP DENGAN LINGKUNGAN

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Dharmawati Dharmawati

2016-08-01

Full Text Available This study aims to generate critical thinking assessment instrument for seven graders within organism interaction in an environment with an appropriate validity and reliability level. The design of this instrument is developed using stages suggested by Borg and Gall. The stages are researching and collecting information, planning, developing a preliminary product, conducting the limited examination, revising product from limited examination, field testing, revising product from field testing, and finalizing product. The result of content and construction validation shows that the level of feasibility is 88,35% and categorized as very feasible. While the degree of readability of assessment items is 93,51% and it is categorized as excellent. The coefficient of inter-rater reliability of assessment items is 0,951 and categorized as excellent. The instrument acquires reliability coefficient 0,792 for multiple choice and 0,753 for essay items. This study shows that the content, construction, and items in assessment are feasible. Penelitian ini bertujuan untuk menghasilkan instrumen asesmen berpikir kritis untuk siswa SMP kelas VII pada materi interaksi makhluk hidup dengan lingkungan dengan tingkat validitas dan reliabilitas yang memadai. Rancangan penelitian menggunakan model pengembangan menurut Borg & Gall, yang meliputi langkah-langkah: penelitian dan pengumpulan informasi, perencanaan, pengembangan produk awal, uji coba terbatas, revisi produk uji coba terbatas, uji coba lapangan, revisi uji coba produk lapangan, dan penyempurnaan produk akhir. Berdasarkan hasil validasi isi dan konstruk diperoleh tingkat kelayakan produk sebesar 88,35% berada pada kriteria sangat layak. Tingkat keterbacaan soal asesmen sebesar 93,51% dengan kategori sangat baik. Koefisien inter-rater reliability pada soal asesmen bentuk penugasan sebesar 0,951 dengan kategori sangat baik. Instrumen tersebut mempunyai koefisien reliabilitas sebesar 0,792 (soal pilihan ganda dan

A Model of How Different Biology Experts Explain Molecular and Cellular Mechanisms

Science.gov (United States)

Trujillo, Caleb M.; Anderson, Trevor R.; Pelaez, Nancy J.

2015-01-01

Constructing explanations is an essential skill for all science learners. The goal of this project was to model the key components of expert explanation of molecular and cellular mechanisms. As such, we asked: What is an appropriate model of the components of explanation used by biology experts to explain molecular and cellular mechanisms? Do…

Quantitative computational models of molecular self-assembly in systems biology.

Science.gov (United States)

Thomas, Marcus; Schwartz, Russell

2017-05-23

Molecular self-assembly is the dominant form of chemical reaction in living systems, yet efforts at systems biology modeling are only beginning to appreciate the need for and challenges to accurate quantitative modeling of self-assembly. Self-assembly reactions are essential to nearly every important process in cell and molecular biology and handling them is thus a necessary step in building comprehensive models of complex cellular systems. They present exceptional challenges, however, to standard methods for simulating complex systems. While the general systems biology world is just beginning to deal with these challenges, there is an extensive literature dealing with them for more specialized self-assembly modeling. This review will examine the challenges of self-assembly modeling, nascent efforts to deal with these challenges in the systems modeling community, and some of the solutions offered in prior work on self-assembly specifically. The review concludes with some consideration of the likely role of self-assembly in the future of complex biological system models more generally.

Palm-based diacylglycerol fat dry fractionation: effect of crystallisation temperature, cooling rate and agitation speed on physical and chemical properties of fractions

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Razam Ab Latip

2013-05-01

Full Text Available Fractionation which separates the olein (liquid and stearin (solid fractions of oil is used to modify the physicochemical properties of fats in order to extend its applications. Studies showed that the properties of fractionated end products can be affected by fractionation processing conditions. In the present study, dry fractionation of palm-based diacylglycerol (PDAG was performed at different: cooling rates (0.05, 0.5, 1.0, 1.5, 2.0, 2.5 and 3.0°C/min, end-crystallisation temperatures (30, 35, 40, 45 and 50°C and agitation speeds (30, 50, 70, 90 and 110 rpm to determine the effect of these parameters on the properties and yield of the solid and liquid portions. To determine the physicochemical properties of olein and stearin fraction: Iodine value (IV, fatty acid composition (FAC, acylglycerol composition, slip melting point (SMP, solid fat content (SFC, thermal behaviour tests were carried out. Fractionation of PDAG fat changes the chemical composition of liquid and solid fractions. In terms of FAC, the major fatty acid in olein and stearin fractions were oleic (C18:1 and palmitic (C16:0 respectively. Acylglycerol composition showed that olein and stearin fractions is concentrated with TAG and DAG respectively. Crystallization temperature, cooling rate and agitation speed does not affect the IV, SFC, melting and cooling properties of the stearin fraction. The stearin fraction was only affected by cooling rate which changes its SMP. On the other hand, olein fraction was affected by crystallization temperature and cooling rate but not agitation speed which caused changes in IV, SMP, SFC, melting and crystallization behavior. Increase in both the crystallization temperature and cooling rate caused a reduction of IV, increment of the SFC, SMP, melting and crystallization behaviour of olein fraction and vice versa. The fractionated stearin part melted above 65°C while the olein melted at 40°C. SMP in olein fraction also reduced to a range of

PENINGKATAN KEAKTIFAN DAN HASIL BELAJAR IPS MELALUI PAKEM DENGAN BANTUAN MEDIA PADA SISWA KELAS VIIIA SMP NEGERI 1 KANDEMAN BATANG TAHUN PELAJARAN 2013/2014

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Wulan Dwi Aryani

2014-06-01

Full Text Available The purpose of this research is to improve: (1 The active participation of student learning, (2 the attitude of students towards learning social studies, (3 Complete results of social studies. Subjects of this study 40 eighth grade students of SMP N 1 Kandeman A Trunk academic year 2013 / 2014.Teknik data collection used were: observation, interview, questionnaire, achievement test, documentation, and field notes. Data analysis using quantitative analysis. The results of the study are as follows. (1 There is an average increase of eight observations activeness of student learning, in the first cycle mean score of 64.69 (high; second cycle mean score of 71.94 (high, the third cycle mean score of 84.50 (very high. (2 There is an increase in students' attitudes toward learning social studies, the mean value of the first cycle 68 (good, the average value of the second cycle 77 (good, and the mean value of the third cycle 85.75 (very good. (3 There is an increasing mastery IPS student learning outcomes, in the first cycle learning AJEL strategy, media, liveliness, and learning outcomes completeness 67.5% with a mean value of 74, the second cycle, 77.5% with a mean value of 78, the third cycle of 85% with a mean value of 83.65. By usin three different media in each cycle there are three prominent increase in activity in the ranking are: pay attention to the material, noting the results of the discussion, and the spirit in the move. Thus the use AJEL strategy with the help of the media in social studies learning can enhance

Modeling of nanotoxicity molecular interactions of nanomaterials with bionanomachines

CERN Document Server

Zhou, Ruhong

2015-01-01

This book provides a comprehensive overview of the fundamentals of nanotoxicity modeling and its implications for the development of novel nanomedicines. It lays out the fundamentals of nanotoxicity modeling for an array of nanomaterial systems, ranging from carbon-based nanoparticles to noble metals, metal oxides, and quantum dots. The author illustrates how molecular (classical mechanics) and atomic (quantum mechanics) modeling approaches can be applied to bolster our understanding of many important aspects of this critical nanotoxicity issue. Each chapter is organized by types of nanomaterials for practicality, making this an ideal book for senior undergraduate students, graduate students, and researchers in nanotechnology, chemistry, physics, molecular biology, and computer science. It is also of interest to academic and industry professionals who work on nanodrug delivery and related biomedical applications, and aids readers in their biocompatibility assessment efforts in the coming age of nanotechnology...

Molecular Model of a Quantum Dot Beyond the Constant Interaction Approximation

Science.gov (United States)

Temirov, Ruslan; Green, Matthew F. B.; Friedrich, Niklas; Leinen, Philipp; Esat, Taner; Chmielniak, Pawel; Sarwar, Sidra; Rawson, Jeff; Kögerler, Paul; Wagner, Christian; Rohlfing, Michael; Tautz, F. Stefan

2018-05-01

We present a physically intuitive model of molecular quantum dots beyond the constant interaction approximation. It accurately describes their charging behavior and allows the extraction of important molecular properties that are otherwise experimentally inaccessible. The model is applied to data recorded with a noncontact atomic force microscope on three different molecules that act as a quantum dot when attached to the microscope tip. The results are in excellent agreement with first-principles simulations.

Prediction of Sliding Friction Coefficient Based on a Novel Hybrid Molecular-Mechanical Model.

Science.gov (United States)

Zhang, Xiaogang; Zhang, Yali; Wang, Jianmei; Sheng, Chenxing; Li, Zhixiong

2018-08-01

Sliding friction is a complex phenomenon which arises from the mechanical and molecular interactions of asperities when examined in a microscale. To reveal and further understand the effects of micro scaled mechanical and molecular components of friction coefficient on overall frictional behavior, a hybrid molecular-mechanical model is developed to investigate the effects of main factors, including different loads and surface roughness values, on the sliding friction coefficient in a boundary lubrication condition. Numerical modelling was conducted using a deterministic contact model and based on the molecular-mechanical theory of friction. In the contact model, with given external loads and surface topographies, the pressure distribution, real contact area, and elastic/plastic deformation of each single asperity contact were calculated. Then asperity friction coefficient was predicted by the sum of mechanical and molecular components of friction coefficient. The mechanical component was mainly determined by the contact width and elastic/plastic deformation, and the molecular component was estimated as a function of the contact area and interfacial shear stress. Numerical results were compared with experimental results and a good agreement was obtained. The model was then used to predict friction coefficients in different operating and surface conditions. Numerical results explain why applied load has a minimum effect on the friction coefficients. They also provide insight into the effect of surface roughness on the mechanical and molecular components of friction coefficients. It is revealed that the mechanical component dominates the friction coefficient when the surface roughness is large (Rq > 0.2 μm), while the friction coefficient is mainly determined by the molecular component when the surface is relatively smooth (Rq < 0.2 μm). Furthermore, optimal roughness values for minimizing the friction coefficient are recommended.

Energetics and efficiency of a molecular motor model

DEFF Research Database (Denmark)

C. Fogedby, Hans; Svane, Axel

2013-01-01

The energetics and efficiency of a linear molecular motor model proposed by Mogilner et al. (Phys. Lett. 237, 297 (1998)) is analyzed from an analytical point of view. The model which is based on protein friction with a track is described by coupled Langevin equations for the motion in combination...... when incorporating the full motor dynamics, owing to the strong dissipation associated with the motor action....

Modeling ramp compression experiments using large-scale molecular dynamics simulation.

Energy Technology Data Exchange (ETDEWEB)

Mattsson, Thomas Kjell Rene; Desjarlais, Michael Paul; Grest, Gary Stephen; Templeton, Jeremy Alan; Thompson, Aidan Patrick; Jones, Reese E.; Zimmerman, Jonathan A.; Baskes, Michael I. (University of California, San Diego); Winey, J. Michael (Washington State University); Gupta, Yogendra Mohan (Washington State University); Lane, J. Matthew D.; Ditmire, Todd (University of Texas at Austin); Quevedo, Hernan J. (University of Texas at Austin)

2011-10-01

Molecular dynamics simulation (MD) is an invaluable tool for studying problems sensitive to atomscale physics such as structural transitions, discontinuous interfaces, non-equilibrium dynamics, and elastic-plastic deformation. In order to apply this method to modeling of ramp-compression experiments, several challenges must be overcome: accuracy of interatomic potentials, length- and time-scales, and extraction of continuum quantities. We have completed a 3 year LDRD project with the goal of developing molecular dynamics simulation capabilities for modeling the response of materials to ramp compression. The techniques we have developed fall in to three categories (i) molecular dynamics methods (ii) interatomic potentials (iii) calculation of continuum variables. Highlights include the development of an accurate interatomic potential describing shock-melting of Beryllium, a scaling technique for modeling slow ramp compression experiments using fast ramp MD simulations, and a technique for extracting plastic strain from MD simulations. All of these methods have been implemented in Sandia's LAMMPS MD code, ensuring their widespread availability to dynamic materials research at Sandia and elsewhere.

FROM ATOMISTIC TO SYSTEMATIC COARSE-GRAINED MODELS FOR MOLECULAR SYSTEMS

KAUST Repository

Harmandaris, Vagelis; Kalligiannaki, Evangelia; Katsoulakis, Markos; Plechac, Petr

2017-01-01

The development of systematic (rigorous) coarse-grained mesoscopic models for complex molecular systems is an intense research area. Here we first give an overview of methods for obtaining optimal parametrized coarse-grained models, starting from

Diffusion-controlled interface kinetics-inclusive system-theoretic propagation models for molecular communication systems

Science.gov (United States)

Chude-Okonkwo, Uche A. K.; Malekian, Reza; Maharaj, B. T.

2015-12-01

Inspired by biological systems, molecular communication has been proposed as a new communication paradigm that uses biochemical signals to transfer information from one nano device to another over a short distance. The biochemical nature of the information transfer process implies that for molecular communication purposes, the development of molecular channel models should take into consideration diffusion phenomenon as well as the physical/biochemical kinetic possibilities of the process. The physical and biochemical kinetics arise at the interfaces between the diffusion channel and the transmitter/receiver units. These interfaces are herein termed molecular antennas. In this paper, we present the deterministic propagation model of the molecular communication between an immobilized nanotransmitter and nanoreceiver, where the emission and reception kinetics are taken into consideration. Specifically, we derived closed-form system-theoretic models and expressions for configurations that represent different communication systems based on the type of molecular antennas used. The antennas considered are the nanopores at the transmitter and the surface receptor proteins/enzymes at the receiver. The developed models are simulated to show the influence of parameters such as the receiver radius, surface receptor protein/enzyme concentration, and various reaction rate constants. Results show that the effective receiver surface area and the rate constants are important to the system's output performance. Assuming high rate of catalysis, the analysis of the frequency behavior of the developed propagation channels in the form of transfer functions shows significant difference introduce by the inclusion of the molecular antennas into the diffusion-only model. It is also shown that for t > > 0 and with the information molecules' concentration greater than the Michaelis-Menten kinetic constant of the systems, the inclusion of surface receptors proteins and enzymes in the models

The characteristics of extracellular polymeric substances and soluble microbial products in moving bed biofilm reactor-membrane bioreactor.

Science.gov (United States)

Duan, Liang; Jiang, Wei; Song, Yonghui; Xia, Siqing; Hermanowicz, Slawomir W

2013-11-01

The characteristics of extracellular polymeric substances (EPS) and soluble microbial products (SMP) in conventional membrane bioreactor (MBR) and in moving bed biofilm reactor-membrane bioreactors (MBBR-MBR) were investigated in long-term (170 days) experiments. The results showed that all reactors had high removal efficiency of ammonium and COD, despite very different fouling conditions. The MBBR-MBR with media fill ratio of 26.7% had much lower total membrane resistance and no obvious fouling were detected during the whole operation. In contrast, MBR and MBBR-MBR with lower and higher media fill experienced more significant fouling. Low fouling at optimum fill ratio may be due to the higher percentage of small molecular size (100 kDa) of EPS and SMP in the reactor. The composition of EPS and SMP affected fouling due to different O-H bonds in hydroxyl functional groups, and less polysaccharides and lipids. Copyright © 2013 Elsevier Ltd. All rights reserved.

Impact of synthetic or real urban wastewater on membrane bioreactor (MBR) performances and membrane fouling under stable conditions.

Science.gov (United States)

Villain, Maud; Bourven, Isabelle; Guibaud, Gilles; Marrot, Benoît

2014-03-01

Influence of substrate type (synthetic (SWW) or real wastewater (RWW)) on lab scale MBR performances (e.g. COD and N-NH4(+) removal rates and bioactivities) was assessed. Membrane fouling was related to MBR biological medium characteristics. With RWW, autotrophic biomass was better acclimated with complete ammonium removal. MBR biological medium was characterized by main soluble microbial products (SMP) (proteins, polysaccharides and humic-like substances) quantification and molecular weights (MW) distribution determination. The biological medium of SWW acclimation contained 60mgL(-1) more of SMP, mainly composed of proteins and polysaccharides. A protein fraction having high MW (>600kDa) could be responsible for higher removable fouling fraction in that case. SMP of RWW experiment were mainly composed of small proteic and humic-like fractions, poorly retained by the membrane and resulting in a weak augmentation of irremovable and irreversible fouling fractions compared to SWW acclimation. Therefore RWW utilization is preferable to approach real operating MBR. Copyright © 2013 Elsevier Ltd. All rights reserved.

Molecular modeling of protonic acid doping of emeraldine base polyaniline for chemical sensors

NARCIS (Netherlands)

Chen, X.; Yuan, C.A.; Wong, C.K.Y.; Ye, H.; Leung, S.Y.Y.; Zhang, G.

2012-01-01

We proposed a molecular modeling methodology to study the protonic acid doping of emeraldine base polyaniline which can used in gas detection. The commercial forcefield COMPASS was used for the polymer and protonic acid molecules. The molecular model, which is capable of representing the polyaniline

Experimental and modelling studies of the shape memory properties of amorphous polymer network composites

International Nuclear Information System (INIS)

Arrieta, J S; Diani, J; Gilormini, P

2014-01-01

Shape memory polymer composites (SMPCs) have become an important way to leverage improvements in the development of applications featuring shape memory polymers (SMPs). In this study, an amorphous SMP matrix has been filled with different types of reinforcements. An experimental set of results is presented and then compared to three-dimensional (3D) finite-element simulations. Thermomechanical shape memory cycles were performed in uniaxial tension. The fillers effect was studied in stress-free and constrained-strain recoveries. Experimental observations indicate complete shape recovery and put in evidence the increased sensitivity of constrained length stress recoveries to the heating ramp on the tested composites. The simulations reproduced a simplified periodic reinforced composite and used a model for the matrix material that has been previously tested on regular SMPs. The latter combines viscoelasticity at finite strain and time-temperature superposition. The simulations easily allow representation of the recovery properties of a reinforced SMP. (paper)

Molecular structure based property modeling: Development/ improvement of property models through a systematic property-data-model analysis

DEFF Research Database (Denmark)

Hukkerikar, Amol Shivajirao; Sarup, Bent; Sin, Gürkan

2013-01-01

models. To make the property-data-model analysis fast and efficient, an approach based on the “molecular structure similarity criteria” to identify molecules (mono-functional, bi-functional, etc.) containing specified set of structural parameters (that is, groups) is employed. The method has been applied...

VHDL-AMS Simulation Framework for Molecular-FET Device-to-Circuit Modeling and Design

Directory of Open Access Journals (Sweden)

Mariagrazia Graziano

2018-01-01

Full Text Available We concentrate on Molecular-FET as a device and present a new modular framework based on VHDL-AMS. We have implemented different Molecular-FET models within the framework. The framework allows comparison between the models in terms of the capability to calculate accurate I-V characteristics. It also provides the option to analyze the impact of Molecular-FET and its implementation in the circuit with the extension of its use in an architecture based on the crossbar configuration. This analysis evidences the effect of choices of technological parameters, the ability of models to capture the impact of physical quantities, and the importance of considering defects at circuit fabrication level. The comparison tackles the computational efforts of different models and techniques and discusses the trade-off between accuracy and performance as a function of the circuit analysis final requirements. We prove this methodology using three different models and test them on a 16-bit tree adder included in Pentium 4 that, to the best of our knowledge, is the biggest circuits based on molecular device ever designed and analyzed.

Molecular weight kinetics and chain scission models for dextran polymers during ultrasonic degradation.

Science.gov (United States)

Pu, Yuanyuan; Zou, Qingsong; Hou, Dianzhi; Zhang, Yiping; Chen, Shan

2017-01-20

Ultrasonic degradation of six dextran samples with different initial molecular weights (IMW) has been performed to investigate the degradation behavior and chain scission mechanism of dextrans. The weight-average molecular weight (Mw) and polydispersity index (D value) were monitored by High Performance Gel Permeation Chromatography (HPGPC). Results showed that Mw and D value decreased with increasing ultrasonic time, resulting in a more homologous dextran solution with lower molecular weight. A significant degradation occurred in dextrans with higher IMW, particularly at the initial stage of the ultrasonic treatment. The Malhotra model was found to well describe the molecular weight kinetics for all dextran samples. Experimental data was fitted into two chain scission models to study dextran chain scission mechanism and the model performance was compared. Results indicated that the midpoint scission model agreed well with experimental results, with a linear regression factor of R 2 >0.99. Copyright © 2016 Elsevier Ltd. All rights reserved.

Hierarchical modeling of molecular energies using a deep neural network

Science.gov (United States)

Lubbers, Nicholas; Smith, Justin S.; Barros, Kipton

2018-06-01

We introduce the Hierarchically Interacting Particle Neural Network (HIP-NN) to model molecular properties from datasets of quantum calculations. Inspired by a many-body expansion, HIP-NN decomposes properties, such as energy, as a sum over hierarchical terms. These terms are generated from a neural network—a composition of many nonlinear transformations—acting on a representation of the molecule. HIP-NN achieves the state-of-the-art performance on a dataset of 131k ground state organic molecules and predicts energies with 0.26 kcal/mol mean absolute error. With minimal tuning, our model is also competitive on a dataset of molecular dynamics trajectories. In addition to enabling accurate energy predictions, the hierarchical structure of HIP-NN helps to identify regions of model uncertainty.

Multimedia environmental chemical partitioning from molecular information

International Nuclear Information System (INIS)

Martinez, Izacar; Grifoll, Jordi; Giralt, Francesc; Rallo, Robert

2010-01-01

The prospect of assessing the environmental distribution of chemicals directly from their molecular information was analyzed. Multimedia chemical partitioning of 455 chemicals, expressed in dimensionless compartmental mass ratios, was predicted by SimpleBox 3, a Level III Fugacity model, together with the propagation of reported uncertainty for key physicochemical and transport properties, and degradation rates. Chemicals, some registered in priority lists, were selected according to the availability of experimental property data to minimize the influence of predicted information in model development. Chemicals were emitted in air or water in a fixed geographical scenario representing the Netherlands and characterized by five compartments (air, water, sediments, soil and vegetation). Quantitative structure-fate relationship (QSFR) models to predict mass ratios in different compartments were developed with support vector regression algorithms. A set of molecular descriptors, including the molecular weight and 38 counts of molecular constituents were adopted to characterize the chemical space. Out of the 455 chemicals, 375 were used for training and testing the QSFR models, while 80 were excluded from model development and were used as an external validation set. Training and test chemicals were selected and the domain of applicability (DOA) of the QSFRs established by means of self-organizing maps according to structural similarity. Best results were obtained with QSFR models developed for chemicals belonging to either the class [C] and [C; O], or the class with at least one heteroatom different than oxygen in the structure. These two class-specific models, with respectively 146 and 229 chemicals, showed a predictive squared coefficient of q 2 ≥ 0.90 both for air and water, which respectively dropped to q 2 ∼ 0.70 and 0.40 for outlying chemicals. Prediction errors were of the same order of magnitude as the deviations associated to the uncertainty of the

Temperature effects on multiphase reactions of organic molecular markers: A modeling study

Science.gov (United States)

Pratap, Vikram; Chen, Ying; Yao, Guangming; Nakao, Shunsuke

2018-04-01

Various molecular markers are used in source apportionment studies. In early studies, molecular markers were assumed to be inert. However, recent studies suggest that molecular markers can decay rapidly through multiphase reactions, which makes interpretation of marker measurements challenging. This study presents a simplified model to account for the effects of temperature and relative humidity on the lifetime of molecular markers through a shift in gas-particle partitioning as well as a change in viscosity of the condensed phase. As a model case, this study examines the stability of levoglucosan, a key marker species of biomass burning, over a wide temperature range relevant to summertime and wintertime. Despite the importance of wood combustion for space heating in winter, the lifetime of levoglucosan in wintertime is not well understood. The model predicts that in low-temperature conditions, levoglucosan predominantly remains in the particle phase, and therefore its loss due to gas-phase oxidation reactions is significantly reduced. Furthermore, the movement of the levoglucosan from the bulk of the particle to the particle surface is reduced due to low diffusivity in the semi-solid state. The simplified model developed in this study reasonably reproduces upper and lower bounds of the lifetime of levoglucosan investigated in previous studies. The model results show that the levoglucosan depletion after seven days reduces significantly from ∼98% at 25 °C to marker (lifetime > 1 week) even at 60% relative humidity irrespective of the assumed fragility parameter D that controls estimated diffusivity. The model shows that lifetime of an organic molecular marker strongly depends on assumed D especially when a semi-volatile marker is in semi-solid organic aerosol.

The mechanical properties modeling of nano-scale materials by molecular dynamics

NARCIS (Netherlands)

Yuan, C.; Driel, W.D. van; Poelma, R.; Zhang, G.Q.

2012-01-01

We propose a molecular modeling strategy which is capable of mod-eling the mechanical properties on nano-scale low-dielectric (low-k) materials. Such modeling strategy has been also validated by the bulking force of carbon nano tube (CNT). This modeling framework consists of model generation method,

Assessment of radiofrequency exposure from cellular telephone daily use in an epidemiological study

DEFF Research Database (Denmark)

Berg, Gabriele; Schüz, Joachim; Samkange-Zeeb, Florence

2005-01-01

emitted by the mobile phone handset during each base station contact. Information on cellular phone use for the same time period from traffic records of the network providers and from face-to-face interviews with the participants 3 months after the SMP use was assessed. Pearson's correlation coefficients...... and linear regression models were used to analyse the association between information from the interview and from the SMP. RESULTS: In total, 1757 personal mobile phone calls were recorded for 45 persons by SMP and traffic records. The correlation between the self-reported information about the number...

THE INFLUENCE OF USING TIME TOKEN METHOD TOWARD SPEAKING ABILITY AT THE STUDENTS’ OF SMP N 1 BATANGHARI ACADEMICYEAR 2014/2015

Directory of Open Access Journals (Sweden)

Retno Fentari

2016-04-01

Full Text Available The objective of the study is to know whether there is influence of Time Token method toward students’ speaking ability. The research design of this research is Quantitative Design. The population of this research is 625 students. It consists of 21 classes and average of each class consists of 32 students. The researchers conducted the research at the eighth grade of SMP N 1 Batanghari. The researcher took 64 students from the total population as the sample. This research takes two classes: they are experimental class and control class. In Colleting the data, the researcher used test. The test comprised two tests: pre test and post test. To analyze data, the researcher used ttest formula. The result of the study showed that tcount5,37 and tdaf is 2,00 (on criteria1 and 2,66 (on criteria 2. It means that tcount >tdaf. And the criteria of tcount is Ha accepted if tcount>tdaf. Key Words: Time Token Method, Speaking Ability

Virtual Treatment of Basilar Aneurysms Using Shape Memory Polymer Foam

Science.gov (United States)

Ortega, J.M.; Hartman, J.; Rodriguez, J.N.; Maitland, D.J.

2013-01-01

Numerical simulations are performed on patient-specific basilar aneurysms that are treated with shape memory polymer (SMP) foam. In order to assess the post-treatment hemodynamics, two modeling approaches are employed. In the first, the foam geometry is obtained from a micro-CT scan and the pulsatile blood flow within the foam is simulated for both Newtonian and non-Newtonian viscosity models. In the second, the foam is represented as a porous media continuum, which has permeability properties that are determined by computing the pressure gradient through the foam geometry over a range of flow speeds comparable to those of in vivo conditions. Virtual angiography and additional post-processing demonstrate that the SMP foam significantly reduces the blood flow speed within the treated aneurysms, while eliminating the high-frequency velocity fluctuations that are present within the pre-treatment aneurysms. An estimation of the initial locations of thrombus formation throughout the SMP foam is obtained by means of a low fidelity thrombosis model that is based upon the residence time and shear rate of blood. The Newtonian viscosity model and the porous media model capture similar qualitative trends, though both yield a smaller volume of thrombus within the SMP foam. PMID:23329002

Understanding valence-shell electron-pair repulsion (VSEPR) theory using origami molecular models

International Nuclear Information System (INIS)

Saraswati, Teguh Endah; Saputro, Sulistyo; Ramli, Murni; Praseptiangga, Danar; Khasanah, Nurul; Marwati, Sri

2017-01-01

Valence-shell electron-pair repulsion (VSEPR) theory is conventionally used to predict molecular geometry. However, it is difficult to explore the full implications of this theory by simply drawing chemical structures. Here, we introduce origami modelling as a more accessible approach for exploration of the VSEPR theory. Our technique is simple, readily accessible and inexpensive compared with other sophisticated methods such as computer simulation or commercial three-dimensional modelling kits. This method can be implemented in chemistry education at both the high school and university levels. We discuss the example of a simple molecular structure prediction for ammonia (NH 3 ). Using the origami model, both molecular shape and the scientific justification can be visualized easily. This ‘hands-on’ approach to building molecules will help promote understanding of VSEPR theory. (paper)

Understanding valence-shell electron-pair repulsion (VSEPR) theory using origami molecular models

Science.gov (United States)

Endah Saraswati, Teguh; Saputro, Sulistyo; Ramli, Murni; Praseptiangga, Danar; Khasanah, Nurul; Marwati, Sri

2017-01-01

Valence-shell electron-pair repulsion (VSEPR) theory is conventionally used to predict molecular geometry. However, it is difficult to explore the full implications of this theory by simply drawing chemical structures. Here, we introduce origami modelling as a more accessible approach for exploration of the VSEPR theory. Our technique is simple, readily accessible and inexpensive compared with other sophisticated methods such as computer simulation or commercial three-dimensional modelling kits. This method can be implemented in chemistry education at both the high school and university levels. We discuss the example of a simple molecular structure prediction for ammonia (NH3). Using the origami model, both molecular shape and the scientific justification can be visualized easily. This ‘hands-on’ approach to building molecules will help promote understanding of VSEPR theory.

Quantification of the inert chemical oxygen demand of raw wastewater and evaluation of soluble microbial product production in demo-scale upflow anaerobic sludge blanket reactors under different operational conditions.

Science.gov (United States)

Aquino, Sergio F; Gloria, Roberto M; Silva, Silvana Q; Chernicharo, Carlos A L

2009-06-01

This paper investigates the production of soluble microbial products (SMPs) in demonstration-scale upflow anaerobic sludge blanket reactors operated under different conditions and fed with raw wastewater. The results showed that 9.2 +/- 1.3% of the influent soluble chemical oxygen demand (COD) could be considered inert to anaerobic treatment and that the amount of COD produced by biomass varied from 30 to 70 mg x L(-1), accounting for 45 to 63% of the soluble effluent COD. The accumulation of SMP appeared to be dependent on the hydraulic retention time (HRT) applied to the reactors, with a larger accumulation of SMP observed at the lowest HRT (5 hours); this may have been due to stress conditions caused by high upflow velocity (1.1 m x h(-1)). In terms of residual COD characterization, ultrafiltration results showed that higher amounts of high molecular weight compounds were found when HRT was the lowest (5 hours), and that the molecular weight distribution depended on the operational condition of the reactors. Biodegradability tests showed that the low and high molecular weight SMPs were only partially degraded anaerobically (10 to 60%) and that the high molecular weight SMPs were difficult to degrade aerobically.

MODEL PEMBELAJARAN NEUROLINGUISTIC PROGRAMMING BERORIENTASI KARAKTER BAGI PENINGKATAN KEMAMPUAN MENULIS SISWA SMP

Directory of Open Access Journals (Sweden)

Wikanengsih -

2014-06-01

Abstrak: Model Pembelajaran Neurolinguistic Programming Berorientasi Karakter untuk Mening­katkan Kemampuan Menulis Siswa. Penelitian ini bertujuan untuk mengetahui keefektifan model pem­belajaran neurolinguistik programming berorientasi karakter (MPNLPBK terhadap kemampuan menulis siswa. Metode penelitian yang digunakan metode penelitian kombinasi (mixed method jenis sequential exploratory strategy. Hasil penelitian tahap pertama (penelitian kualitatif menghasilkan model pembelajaran hipotetik. Penelitian tahap kedua merupakan uji coba penerapan model hipotetik (penelitian kuantitatif. Hasil pengujian menunjukkan bahwa pembelajaran menulis dengan menggunakan MPNLPBK dapat meningkatkan kemampuan menulis siswa kelompok eksperimen. Selain itu, berdasarkan hasil pengamatan terhadap aspek karakter komunikatif, toleran, tanggungjawab dan kreatif siswa, terdapat perkembangan pada diri siswa untuk setiap aspek tersebut.

Model-Model Partisipasi Dalam Dunia Pendidikan Di Kota Samarinda

Directory of Open Access Journals (Sweden)

Muhammad Iwan Abdi

2012-12-01

Full Text Available Participation is an active and initiative process that comes from citizen where it will be realized as an actual effort if fulfilling three factors; a good will, ability and a change to participate. In the context of education, the social participation is found in the form the people participation to the process of education. That participation and involvement can be in terms of management development aspect, curriculum, to the learning process. This paper tries to describe the models of social participation at SMP Plus Melati since this is one of the best schools in Samarinda. The models of social participation were found, such as: institutional, educative, and cultural participation. There are also some cooperation, such as: institutional mutual understanding, managerial development, finance, curriculum, and cooperation with some Moslem leaders in Samarinda.

Cross-link guided molecular modeling with ROSETTA.

Directory of Open Access Journals (Sweden)

Abdullah Kahraman

Full Text Available Chemical cross-links identified by mass spectrometry generate distance restraints that reveal low-resolution structural information on proteins and protein complexes. The technology to reliably generate such data has become mature and robust enough to shift the focus to the question of how these distance restraints can be best integrated into molecular modeling calculations. Here, we introduce three workflows for incorporating distance restraints generated by chemical cross-linking and mass spectrometry into ROSETTA protocols for comparative and de novo modeling and protein-protein docking. We demonstrate that the cross-link validation and visualization software Xwalk facilitates successful cross-link data integration. Besides the protocols we introduce XLdb, a database of chemical cross-links from 14 different publications with 506 intra-protein and 62 inter-protein cross-links, where each cross-link can be mapped on an experimental structure from the Protein Data Bank. Finally, we demonstrate on a protein-protein docking reference data set the impact of virtual cross-links on protein docking calculations and show that an inter-protein cross-link can reduce on average the RMSD of a docking prediction by 5.0 Å. The methods and results presented here provide guidelines for the effective integration of chemical cross-link data in molecular modeling calculations and should advance the structural analysis of particularly large and transient protein complexes via hybrid structural biology methods.

Thermodynamic Models from Fluctuation Solution Theory Analysis of Molecular Simulations

DEFF Research Database (Denmark)

Christensen, Steen; Peters, Günther H.j.; Hansen, Flemming Yssing

2007-01-01

Fluctuation solution theory (FST) is employed to analyze results of molecular dynamics (MD) simulations of liquid mixtures. The objective is to generate parameters for macroscopic GE-models, here the modified Margules model. We present a strategy for choosing the number of parameters included...

Molecular modeling-driven approach for identification of Janus kinase 1 inhibitors through 3D-QSAR, docking and molecular dynamics simulations.

Science.gov (United States)

Itteboina, Ramesh; Ballu, Srilata; Sivan, Sree Kanth; Manga, Vijjulatha

2017-10-01

Janus kinase 1 (JAK 1) belongs to the JAK family of intracellular nonreceptor tyrosine kinase. JAK-signal transducer and activator of transcription (JAK-STAT) pathway mediate signaling by cytokines, which control survival, proliferation and differentiation of a variety of cells. Three-dimensional quantitative structure activity relationship (3 D-QSAR), molecular docking and molecular dynamics (MD) methods was carried out on a dataset of Janus kinase 1(JAK 1) inhibitors. Ligands were constructed and docked into the active site of protein using GLIDE 5.6. Best docked poses were selected after analysis for further 3 D-QSAR analysis using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) methodology. Employing 60 molecules in the training set, 3 D-QSAR models were generate that showed good statistical reliability, which is clearly observed in terms of r 2 ncv and q 2 loo values. The predictive ability of these models was determined using a test set of 25 molecules that gave acceptable predictive correlation (r 2 Pred ) values. The key amino acid residues were identified by means of molecular docking, and the stability and rationality of the derived molecular conformations were also validated by MD simulation. The good consonance between the docking results and CoMFA/CoMSIA contour maps provides helpful clues about the reasonable modification of molecules in order to design more efficient JAK 1 inhibitors. The developed models are expected to provide some directives for further synthesis of highly effective JAK 1 inhibitors.

KEEFEKTIFAN MODEL CONNECTED DAN INTEGRATED DALAM PEMBELAJARAN IPS SMP DI KOTA YOGYAKARTA

OpenAIRE

Idrus idrus

2011-01-01

This research aimed to: (1) analyze the differences in social studies learning achievement between the students using connected and integrated models and those using conventional model; and (2) analyze the hierarchy of the effect of the learning models  among the connected, integrated, and conventional. This experimental research employed a matching post-test comparison group design. The population of this research was National Standardized Schools of Junior Secondary Schools in Yogya...

Model Pembelajaran Neurolinguistic Programming Berorientasi Karakter Bagi Peningkatan Kemampuan Menulis Siswa SMP

OpenAIRE

-, Wikanengsih

2013-01-01

Abstract: Character-oriented Learning Model of Neurolinguistic-Programming to Improve Writing Ability. This mixed-method study aims to determine the effectiveness of character-oriented learning model of neurolinguistic programming (NLP) in improving students' writing ability. Employing a sequential exploratory strategy, this study began the first phase, which was qualitative in nature, to generate the hypo­thetical learning model. The second phase, which was quantitative, was a pilot applicat...

Moving contact lines: linking molecular dynamics and continuum-scale modelling.

Science.gov (United States)

Smith, Edward R; Theodorakis, Panagiotis E; Craster, Richard V; Matar, Omar K

2018-05-04

Despite decades of research, the modelling of moving contact lines has remained a formidable challenge in fluid dynamics whose resolution will impact numerous industrial, biological, and daily-life applications. On the one hand, molecular dynamics (MD) simulation has the ability to provide unique insight into the microscopic details that determine the dynamic behavior of the contact line, which is not possible with either continuum-scale simulations or experiments. On the other hand, continuum-based models provide the link to the macroscopic description of the system. In this Feature Article, we explore the complex range of physical factors, including the presence of surfactants, which govern the contact line motion through MD simulations. We also discuss links between continuum- and molecular-scale modelling, and highlight the opportunities for future developments in this area.

A stochastic phase-field model determined from molecular dynamics

KAUST Repository

von Schwerin, Erik

2010-03-17

The dynamics of dendritic growth of a crystal in an undercooled melt is determined by macroscopic diffusion-convection of heat and by capillary forces acting on the nanometer scale of the solid-liquid interface width. Its modelling is useful for instance in processing techniques based on casting. The phase-field method is widely used to study evolution of such microstructural phase transformations on a continuum level; it couples the energy equation to a phenomenological Allen-Cahn/Ginzburg-Landau equation modelling the dynamics of an order parameter determining the solid and liquid phases, including also stochastic fluctuations to obtain the qualitatively correct result of dendritic side branching. This work presents a method to determine stochastic phase-field models from atomistic formulations by coarse-graining molecular dynamics. It has three steps: (1) a precise quantitative atomistic definition of the phase-field variable, based on the local potential energy; (2) derivation of its coarse-grained dynamics model, from microscopic Smoluchowski molecular dynamics (that is Brownian or over damped Langevin dynamics); and (3) numerical computation of the coarse-grained model functions. The coarse-grained model approximates Gibbs ensemble averages of the atomistic phase-field, by choosing coarse-grained drift and diffusion functions that minimize the approximation error of observables in this ensemble average. © EDP Sciences, SMAI, 2010.

A stochastic phase-field model determined from molecular dynamics

KAUST Repository

von Schwerin, Erik; Szepessy, Anders

2010-01-01

The dynamics of dendritic growth of a crystal in an undercooled melt is determined by macroscopic diffusion-convection of heat and by capillary forces acting on the nanometer scale of the solid-liquid interface width. Its modelling is useful for instance in processing techniques based on casting. The phase-field method is widely used to study evolution of such microstructural phase transformations on a continuum level; it couples the energy equation to a phenomenological Allen-Cahn/Ginzburg-Landau equation modelling the dynamics of an order parameter determining the solid and liquid phases, including also stochastic fluctuations to obtain the qualitatively correct result of dendritic side branching. This work presents a method to determine stochastic phase-field models from atomistic formulations by coarse-graining molecular dynamics. It has three steps: (1) a precise quantitative atomistic definition of the phase-field variable, based on the local potential energy; (2) derivation of its coarse-grained dynamics model, from microscopic Smoluchowski molecular dynamics (that is Brownian or over damped Langevin dynamics); and (3) numerical computation of the coarse-grained model functions. The coarse-grained model approximates Gibbs ensemble averages of the atomistic phase-field, by choosing coarse-grained drift and diffusion functions that minimize the approximation error of observables in this ensemble average. © EDP Sciences, SMAI, 2010.

Multiscale Modeling of PEEK Using Reactive Molecular Dynamics Modeling and Micromechanics

Science.gov (United States)

Pisani, William A.; Radue, Matthew; Chinkanjanarot, Sorayot; Bednarcyk, Brett A.; Pineda, Evan J.; King, Julia A.; Odegard, Gregory M.

2018-01-01

Polyether ether ketone (PEEK) is a high-performance, semi-crystalline thermoplastic that is used in a wide range of engineering applications, including some structural components of aircraft. The design of new PEEK-based materials requires a precise understanding of the multiscale structure and behavior of semi-crystalline PEEK. Molecular Dynamics (MD) modeling can efficiently predict bulk-level properties of single phase polymers, and micromechanics can be used to homogenize those phases based on the overall polymer microstructure. In this study, MD modeling was used to predict the mechanical properties of the amorphous and crystalline phases of PEEK. The hierarchical microstructure of PEEK, which combines the aforementioned phases, was modeled using a multiscale modeling approach facilitated by NASA's MSGMC. The bulk mechanical properties of semi-crystalline PEEK predicted using MD modeling and MSGMC agree well with vendor data, thus validating the multiscale modeling approach.

The Industry 4.0 Journey: Start the Learning Journey with the Reference Architecture Model Industry 4.0

DEFF Research Database (Denmark)

Nardello, Marco; Møller, Charles; Gøtze, John

2017-01-01

The wave of the fourth industrial revolution (Industry 4.0) is breaking on manufacturing companies. In manufacturing, one of the buzzwords of the moment is "Smart production". Smart production involves manufacturing equipment with many sensors that can generate and transmit large amounts of data....... Model Industry 4.0 (RAMI4.0) standard for Smart production. The instantiation contributed to organizational learning in the laboratory by collecting and sharing up-to-date information concerning manufacturing equipment....

Flow of nucleons and fragments in 40Ar+27Al collisions studied with antisymmetrized molecular dynamics

International Nuclear Information System (INIS)

Ono, A.; Horiuchi, H.

1995-01-01

Collective transverse momentum flow of nucleons and fragments in intermediate energy 40 Ar+ 27 Al collisions is calculated with the antisymmetrized molecular dynamics (AMD). The observed flow and its balance energy are reproduced well by calculation with the Gogny force which corresponds to the soft equation of state (EOS) of nuclear matter. The calculated absolute value of the fragment flow is larger than that of the nucleon flow in the negative flow region, which can be explained by the existence of two components of flow. In addition to many similarities, the difference in the deuteron flow is found between 12 C+ 12 C and 40 Ar+ 27 Al collisions, and its origin is investigated by studying the production mechanism of light fragments. We also investigate the dependence of the flow of nucleons and fragments on the stochastic collision cross section and the effective interaction, and conclude that the stiff EOS without momentum dependence of the mean field is not consistent with the experimental data

Digital learning material for experimental design and model building in molecular biology

NARCIS (Netherlands)

Aegerter-Wilmsen, T.

2005-01-01

Designing experimental approaches is a major cognitive skill in molecular biology research, and building models, including quantitative ones, is a cognitive skill which is rapidly gaining importance. Since molecular biology education at university level is aimed at educating future researchers, we

Molecular modeling for the design of novel performance chemicals and materials

CERN Document Server

Rai, Beena

2012-01-01

Molecular modeling (MM) tools offer significant benefits in the design of industrial chemical plants and material processing operations. While the role of MM in biological fields is well established, in most cases MM works as an accessory in novel products/materials development rather than a tool for direct innovation. As a result, MM engineers and practitioners are often seized with the question: ""How do I leverage these tools to develop novel materials or chemicals in my industry?"" Molecular Modeling for the Design of Novel Performance Chemicals and Materials answers this important questio

Forcefields based molecular modeling on the mechanical and physical properties of emeraldine base polyaniline

NARCIS (Netherlands)

Chen, X.; Yuan, C.A.; Wong, K.Y.; Zhang, G.Q.

2010-01-01

Molecular dynamics (MD) and molecular mechanical (MM) analysis are carried out to provide reliable and accurate model for emeraldine base polyaniline. This study validate the forcefields and model with the physical and mechanical properties of the polyaniline. The temperature effects on non-bond

Molecular modeling of auxin transport inhibitors

International Nuclear Information System (INIS)

Gardner, G.; Black-Schaefer, C.; Bures, M.G.

1990-01-01

Molecular modeling techniques have been used to study the chemical and steric properties of auxin transport inhibitors. These bind to a specific site on the plant plasma membrane characterized by its affinity for N-1-naphthylphthalamic acid (NPA). A three-dimensional model was derived from critical features of ligands for the NPA receptor, and a suggested binding conformation is proposed. This model, along with three-dimensional structural searching techniques, was then used to search the Abbott corporate database of chemical structures. Of the 467 compounds that satisfied the search criteria, 77 representative molecules were evaluated for their ability to compete for [ 3 H]NPA binding to corn microsomal membranes. Nineteen showed activity that ranged from 16 to 85% of the maximum NPA binding. Four of the most active of these, from chemical classes not included in the original compound set, also inhibited polar auxin transport through corn coleoptile sections

Bio-AIMS Collection of Chemoinformatics Web Tools based on Molecular Graph Information and Artificial Intelligence Models.

Science.gov (United States)

Munteanu, Cristian R; Gonzalez-Diaz, Humberto; Garcia, Rafael; Loza, Mabel; Pazos, Alejandro

2015-01-01

The molecular information encoding into molecular descriptors is the first step into in silico Chemoinformatics methods in Drug Design. The Machine Learning methods are a complex solution to find prediction models for specific biological properties of molecules. These models connect the molecular structure information such as atom connectivity (molecular graphs) or physical-chemical properties of an atom/group of atoms to the molecular activity (Quantitative Structure - Activity Relationship, QSAR). Due to the complexity of the proteins, the prediction of their activity is a complicated task and the interpretation of the models is more difficult. The current review presents a series of 11 prediction models for proteins, implemented as free Web tools on an Artificial Intelligence Model Server in Biosciences, Bio-AIMS (http://bio-aims.udc.es/TargetPred.php). Six tools predict protein activity, two models evaluate drug - protein target interactions and the other three calculate protein - protein interactions. The input information is based on the protein 3D structure for nine models, 1D peptide amino acid sequence for three tools and drug SMILES formulas for two servers. The molecular graph descriptor-based Machine Learning models could be useful tools for in silico screening of new peptides/proteins as future drug targets for specific treatments.

Toluene model for molecular dynamics simulations in the ranges 298

NARCIS (Netherlands)

Fioroni, M.; Vogt, D.

2004-01-01

An all-atom model for toluene is presented in the framework of classical molecular dynamics (MD). The model has been parametrized under the GROMOS96 force field to reproduce the physicochemical properties of the neat liquid. Four new atom types have been introduced, distinguishing between carbons

Development of the living thing transportation systems worksheet on learning cycle model to increase student understanding

Science.gov (United States)

Rachmawati, E.; Nurohman, S.; Widowati, A.

2018-01-01

This study aims to know: 1) the feasibility LKPD review of aspects of the didactic requirements, construction requirements, technical requirements and compliance with the Learning Cycle. 2) Increase understanding of learners with Learning Model Learning Cycle in SMP N 1 Wates in the form LKPD. 3) The response of learners and educators SMP N 1 Wates to quality LKPD Transportation Systems Beings. This study is an R & D with the 4D model (Define, Design, Develop and Disseminate). Data were analyzed using qualitative analysis and quantitative analysis. Qualitative analysis in the form of advice description and assessment scores from all validates that was converted to a scale of 4. While the analysis of quantitative data by calculating the percentage of materializing learning and achievement using the standard gain an increased understanding and calculation of the KKM completeness evaluation value as an indicator of the achievement of students understanding. the results of this study yield LKPD IPA model learning Cycle theme Transportation Systems Beings obtain 108.5 total scores of a maximum score of 128 including the excellent category (A). LKPD IPA developed able to demonstrate an improved understanding of learners and the response of learners was very good to this quality LKPD IPA.

The effect of moisture absorption on the physical properties of polyurethane shape memory polymer foams

International Nuclear Information System (INIS)

Yu, Ya-Jen; Hearon, Keith; Maitland, Duncan J; Wilson, Thomas S

2011-01-01

The effect of moisture absorption on the glass transition temperature (T g ) and the stress/strain behavior of network polyurethane shape memory polymer (SMP) foams has been investigated. With our ultimate goal of engineering polyurethane SMP foams for use in blood-contacting environments, we have investigated the effects of moisture exposure on the physical properties of polyurethane foams. To the best of our knowledge, this study is the first to investigate the effects of moisture absorption at varying humidity levels (non-immersion and immersion) on the physical properties of polyurethane SMP foams. The SMP foams were exposed to differing humidity levels for varying lengths of time, and they exhibited a maximum water uptake of 8.0% (by mass) after exposure to 100% relative humidity for 96 h. Differential scanning calorimetry results demonstrated that water absorption significantly decreased the T g of the foam, with a maximum water uptake shifting the T g from 67 to 5 °C. Samples that were immersed in water for 96 h and immediately subjected to tensile testing exhibited 100% increases in failure strains and 500% decreases in failure stresses; however, in all cases of time and humidity exposure, the plasticization effect was reversible upon placing moisture-saturated samples in 40% humidity environments for 24 h

Panel 4: Recent Advances in Otitis Media in Molecular Biology, Biochemistry, Genetics, and Animal Models

Science.gov (United States)

Li, Jian-Dong; Hermansson, Ann; Ryan, Allen F.; Bakaletz, Lauren O.; Brown, Steve D.; Cheeseman, Michael T.; Juhn, Steven K.; Jung, Timothy T. K.; Lim, David J.; Lim, Jae Hyang; Lin, Jizhen; Moon, Sung-Kyun; Post, J. Christopher

2014-01-01

Background Otitis media (OM) is the most common childhood bacterial infection and also the leading cause of conductive hearing loss in children. Currently, there is an urgent need for developing novel therapeutic agents for treating OM based on full understanding of molecular pathogenesis in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM. Objective To provide a state-of-the-art review concerning recent advances in OM in the areas of molecular biology, biochemistry, genetics, and animal model studies and to discuss the future directions of OM studies in these areas. Data Sources and Review Methods A structured search of the current literature (since June 2007). The authors searched PubMed for published literature in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM. Results Over the past 4 years, significant progress has been made in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM. These studies brought new insights into our understanding of the molecular and biochemical mechanisms underlying the molecular pathogenesis of OM and helped identify novel therapeutic targets for OM. Conclusions and Implications for Practice Our understanding of the molecular pathogenesis of OM has been significantly advanced, particularly in the areas of inflammation, innate immunity, mucus overproduction, mucosal hyperplasia, middle ear and inner ear interaction, genetics, genome sequencing, and animal model studies. Although these studies are still in their experimental stages, they help identify new potential therapeutic targets. Future preclinical and clinical studies will help to translate these exciting experimental research findings into clinical applications. PMID:23536532

A comparison of molecular dynamics and diffuse interface model predictions of Lennard-Jones fluid evaporation

Energy Technology Data Exchange (ETDEWEB)

Barbante, Paolo [Dipartimento di Matematica, Politecnico di Milano - Piazza Leonardo da Vinci 32 - 20133 Milano (Italy); Frezzotti, Aldo; Gibelli, Livio [Dipartimento di Scienze e Tecnologie Aerospaziali, Politecnico di Milano - Via La Masa 34 - 20156 Milano (Italy)

2014-12-09

The unsteady evaporation of a thin planar liquid film is studied by molecular dynamics simulations of Lennard-Jones fluid. The obtained results are compared with the predictions of a diffuse interface model in which capillary Korteweg contributions are added to hydrodynamic equations, in order to obtain a unified description of the liquid bulk, liquid-vapor interface and vapor region. Particular care has been taken in constructing a diffuse interface model matching the thermodynamic and transport properties of the Lennard-Jones fluid. The comparison of diffuse interface model and molecular dynamics results shows that, although good agreement is obtained in equilibrium conditions, remarkable deviations of diffuse interface model predictions from the reference molecular dynamics results are observed in the simulation of liquid film evaporation. It is also observed that molecular dynamics results are in good agreement with preliminary results obtained from a composite model which describes the liquid film by a standard hydrodynamic model and the vapor by the Boltzmann equation. The two mathematical model models are connected by kinetic boundary conditions assuming unit evaporation coefficient.

A Model of How Different Biology Experts Explain Molecular and Cellular Mechanisms

Science.gov (United States)

Trujillo, Caleb M.; Anderson, Trevor R.; Pelaez, Nancy J.

2015-01-01

Constructing explanations is an essential skill for all science learners. The goal of this project was to model the key components of expert explanation of molecular and cellular mechanisms. As such, we asked: What is an appropriate model of the components of explanation used by biology experts to explain molecular and cellular mechanisms? Do explanations made by experts from different biology subdisciplines at a university support the validity of this model? Guided by the modeling framework of R. S. Justi and J. K. Gilbert, the validity of an initial model was tested by asking seven biologists to explain a molecular mechanism of their choice. Data were collected from interviews, artifacts, and drawings, and then subjected to thematic analysis. We found that biologists explained the specific activities and organization of entities of the mechanism. In addition, they contextualized explanations according to their biological and social significance; integrated explanations with methods, instruments, and measurements; and used analogies and narrated stories. The derived methods, analogies, context, and how themes informed the development of our final MACH model of mechanistic explanations. Future research will test the potential of the MACH model as a guiding framework for instruction to enhance the quality of student explanations. PMID:25999313

Molecular modeling of polymer composite-analyte interactions in electronic nose sensors

Science.gov (United States)

Shevade, A. V.; Ryan, M. A.; Homer, M. L.; Manfreda, A. M.; Zhou, H.; Manatt, K. S.

2003-01-01

We report a molecular modeling study to investigate the polymer-carbon black (CB) composite-analyte interactions in resistive sensors. These sensors comprise the JPL electronic nose (ENose) sensing array developed for monitoring breathing air in human habitats. The polymer in the composite is modeled based on its stereoisomerism and sequence isomerism, while the CB is modeled as uncharged naphthalene rings with no hydrogens. The Dreiding 2.21 force field is used for the polymer, solvent molecules and graphite parameters are assigned to the carbon black atoms. A combination of molecular mechanics (MM) and molecular dynamics (NPT-MD and NVT-MD) techniques are used to obtain the equilibrium composite structure by inserting naphthalene rings in the polymer matrix. Polymers considered for this work include poly(4-vinylphenol), polyethylene oxide, and ethyl cellulose. Analytes studied are representative of both inorganic and organic compounds. The results are analyzed for the composite microstructure by calculating the radial distribution profiles as well as for the sensor response by predicting the interaction energies of the analytes with the composites. c2003 Elsevier Science B.V. All rights reserved.

Molecular modeling in the development of metal radiopharmaceuticals

International Nuclear Information System (INIS)

Green, M.A.

1993-10-01

We began this project with a compilation of a structural library to serve as a data base containing descriptions of the molecular features of metal-labeled radiopharmaceuticals known to efficiently cross the blood-brain barrier. Such a data base is needed in order to identify structural features (size, shape, molecular surface areas and volumes) that are critical in allowing blood-brain barrier penetration. Nine metal complexes have been added to this structural library. We have completed a detailed comparison of four molecular mechanics computer programs QUANTA, SYBYL, BOYD, and MM2DREW to assess their applicability to modeling the structures of low molecular weight metal complexes. We tested the ability of each program to reproduce the crystallographic structures of 38 complexes between nickel(II) and saturated N-donor ligands. The programs were evaluated in terns of their ability to reproduce structural features such as bond lengths, bond angles, and torsion angles. Recently, we investigated the synthesis and characterization of lipophilic cationic gallium complexes with hexadentate bis(salicylaldimine) ligands. This work identified the first gallium-68 radiopharrnaceuticals that can be injected intravenously and that subsequently exhibit significant myocardial uptake followed by prolonged myocardial retention of 68 Ga radioactivity. Tracers of this type remain under investigation as agents for evaluation of myocardial perfusion with positron emission tomography

Quantum molecular dynamics study of the Su-Schrieffer-Heeger model

NARCIS (Netherlands)

Michielsen, Kristel; Raedt, Hans De

A quantum molecular dynamics technique is presented to compute the static and dynamic properties of a system of fermions coupled to classical degrees of freedom. The method is employed to investigate the properties of the Su-Schrieffer-Heeger model, an electron-phonon model which is often used to

Molecular Modeling of Interfacial Behaviors of Nanomaterials

Science.gov (United States)

2007-05-01

potential was originally designed for the modeling of mixed covalent- ionic bonding and was successfully used to describe oxides in crystalline, glassy, and...is separates from the bulk liquid polymer, i.e., the structure of this layer, as influenced by that of the meatal surface, is significantly more...Striolo, J. Kieffer, and P. Cummings, ’Evaluation of Force- fields for molecular simulation of polyhedral oligomeric silsesquioxanes,’ J. Phys. Chem

Contribution of the backstreaming ions to the Self-Magnetic pinch (SMP) diode current

Energy Technology Data Exchange (ETDEWEB)

Mazarakis, Michael G.; Cuneo, Michael E.; Fournier, Sean D.; Johnston, Mark D.; Kiefer, Mark L.; Leckbee, Joshua J.; Nielsen, Dan S.; Oliver, Bryan V.; Simpson, Sean; Renk, Timothy J.; Webb, Timothy J.; Ziska, Derek; Bennett, Nichelle; Droemer, Darryl W.; Cignac, Raymond E.; Obregon, Robert J.; Smith, Chase C.; Wilkins, Frank L.; Welch, Dale R.

2016-08-08

Summary form only given. The results presented here were obtained with an SMP diode mounted at the front high voltage end of the RITS accelerator. RITS is a Self-Magnetically Insulated Transmission Line (MITL) voltage adder that adds the voltage pulses of six 1.3 MV inductively insulated cavities. Our experiments had two objectives: first to measure the contribution of the back-streaming ion currents emitted from the anode target to the diode beam current, and second to try to evaluate the energy of those ions and hence the actual Anode-Cathode (A-K) gap actual voltage. In any very high voltage inductive voltage adder (IVA) utilizing MITLs to transmit the power to the diode load, the precise knowledge of the accelerating voltage applied on the anode-cathode (A-K) gap is problematic. The accelerating voltage quoted in the literature is from estimates based on measurements of the anode and cathode currents of the MITL far upstream from the diode and utilizing the para-potential flow theories and inductive corrections. Thus it would be interesting to have another independent measurement to evaluate the A-K voltage. The diode's anode is made of a number of high Z metals in order to produce copious and energetic flash x-rays. The backstreaming currents are a strong fraction of the anode materials and their stage of cleanness and gas adsorption. We have measured the back-streaming ion currents emitted from the anode and propagating through a hollow cathode tip for various diode configurations and different techniques of target cleaning treatments, such as heating to very high temperatures with DC and pulsed current, with RF plasma cleaning and with both plasma cleaning and heating. Finally, we have also evaluated the A-K gap voltage by ion filtering techniques.

Molecular modelling of a chemodosimeter for the selective detection ...

Indian Academy of Sciences (India)

Wintec

Molecular modelling of a chemodosimeter for the selective detection of. As(III) ion in water. † ... high levels of arsenic cause severe skin diseases in- cluding skin cancer ..... Special Attention to Groundwater in SE Asia (eds) D. Chakraborti, A ...

Shape memory polymer nanocomposites for application of multiple-field active disassembly: experiment and simulation.

Science.gov (United States)

Carrell, John; Zhang, Hong-Chao; Wang, Shiren; Tate, Derrick

2013-11-19

Active disassembly (AD) uses innovative materials that can perform a designed disassembly action by the application of an external field. AD provides improvements over current disassembly processes by limiting machine or manual labor and enabling batch processing for end-of-life products. With improved disassembly operations, more reuse of components and purer recycling streams may be seen. One problem with AD, however, has been with the single-field actuation because of the probability of accidental disassembly. This presentation will discuss the application of shape memory polymer (SMP) nanocomposites in a new AD process. This novel AD process requires multiple-field actuation of the SMP nanocomposite fastener. In the analysis of this AD process, thermal and magnetic field tests were performed on the SMP nanocomposite. From these tests, finite-element analysis was performed to model and simulate the multiple-field AD process. The results of the simulations provide performance variables for the AD process and show a better performance time for the SMP nanocomposite fastener than for a comparable SMP fastener.

Cytogenetic and molecular abnormalities in chronic myelomonocytic leukemia

International Nuclear Information System (INIS)

Patnaik, M M; Tefferi, A

2016-01-01

Chronic myelomonocytic leukemia (CMML) is a clonal stem cell disorder associated with peripheral blood monocytosis and an inherent tendency to transform to acute myeloid leukemia. CMML has overlapping features of myelodysplastic syndromes and myeloproliferative neoplasms. Clonal cytogenetic changes are seen in ~30%, whereas gene mutations are seen in >90% of patients. Common cytogenetic abnormalities include; trisomy 8, -Y, -7/del(7q), trisomy 21 and del(20q), with the Mayo–French risk stratification effectively risk stratifying patients based on cytogenetic abnormalities. Gene mutations frequently involve epigenetic regulators (TET2 ~60%), modulators of chromatin (ASXL1 ~40%), spliceosome components (SRSF2 ~50%), transcription factors (RUNX1 ~15%) and signal pathways (RAS ~30%, CBL ~15%). Of these, thus far, only nonsense and frameshift ASXL1 mutations have been shown to negatively impact overall survival. This has resulted in the development of contemporary, molecularly integrated (inclusive of ASXL1 mutations) CMML prognostic models, including Molecular Mayo Model and the Groupe Français des Myélodysplasies model. Better understanding of the prevalent genetic and epigenetic dysregulation has resulted in emerging targeted treatment options for some patients. The development of an integrated (cytogenetic and molecular) prognostic model along with CMML-specific response assessment criteria are much needed future goals

THE INFLUENCE OF USING THINK PAIR SHARE AND PAIRS CHECK TEHNIQUE TOWARD STUDENTS’ WRITING ABILITY IN RECOUNT TEXT AT THE STUDENTS OF SMP N 2 PEKALONGAN ACADEMIC YEAR 2013/2014

Directory of Open Access Journals (Sweden)

Lia Aris Tantya

2017-02-01

Full Text Available Abstract: The objective of this research are to find out whether, the result of students’ score by using Think Pair Share Technique maximal, the result of students’ score by using Pairs Check Technique maximal and students’ score of Writing Ability in Recount Text, how far the result of Influence of  Using Think Pair Share and Pairs Check Tehnique toward Students Writing Ability in Recount Text. This research is Quantitative research. Research design that will be used in this research is true experimental design. The population of this research is the students’ of SMP N 2 Pekalongan in 2013/2014 that consist of 603 students. The sample is 60 students. As the sample, 30 as experimental class and 30 as  control class. In taking sample, the researcher used the cluster random sampling. The data collecting tehniques the researcher used are try-out, pre-test, treatment and post-test. The data analyzing tehniques, the researcher used normality test, homogenity test and hypothesis test. The differences of both the tehnique are TPS Tehnique can make students enjoy and fun in learning process because it is adopted by Share and can make students be active in learning. Based on the data analysis, the researcher uses t-test formula. The researcher got the result of tobserved = 2.78 and ttable is 2.00. it means that tobserved > ttable. And the criterion of ttest is Ha accepted if tobserved > ttable . So, there is differences between using TPS and Pairs Check tehnique toward students’ writing ability in recount text at the students of SMP N 2 Pekalongan in academic year 2013/2014.

Molecular interaction of PCB153 to human serum albumin: Insights from spectroscopic and molecular modeling studies

Energy Technology Data Exchange (ETDEWEB)

Han, Chao; Fang, Senbiao; Cao, Huiming; Lu, Yan; Ma, Yaqiong [School of Pharmacy, Lanzhou University, Lanzhou 730000 (China); Wei, Dongfeng [Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700 (China); Xie, Xiaoyun [College of Earth and Environmental Science, Lanzhou University, Lanzhou 730000 (China); Liu, Xiaohua [School of Pharmacy, Lanzhou University, Lanzhou 730000 (China); Li, Xin [College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471003 (China); Fei, Dongqing [School of Pharmacy, Lanzhou University, Lanzhou 730000 (China); Zhao, Chunyan, E-mail: zhaochy07@lzu.edu.cn [School of Pharmacy, Lanzhou University, Lanzhou 730000 (China)

2013-03-15

Highlights: ► We identify the binding mode of PCB153 to human serum albumin (HSA). ► Spectroscopic and molecular modeling results reveal that PCB153 binds at the site II. ► The interaction is mainly governed by hydrophobic and hydrogen bond forces. ► The work helps to probe transporting, distribution and toxicity effect of PCBs. -- Abstract: Polychlorinated biphenyls (PCBs) possessed much potential hazard to environment because of its chemical stability and biological toxicity. Here, we identified the binding mode of a representative compound, PCB153, to human serum albumin (HSA) using fluorescence and molecular dynamics simulation methods. The fluorescence study showed that the intrinsic fluorescence of HSA was quenched by addition of PCB153 through a static quenching mechanism. The thermodynamic analysis proved the binding behavior was mainly governed by hydrophobic force. Furthermore, as evidenced by site marker displacement experiments using two probe compounds, it revealed that PCB153 acted exactly on subdomain IIIA (site II) of HSA. On the other hand, the molecular dynamics studies as well as free energy calculations made another important contribution to understand the conformational changes of HSA and the stability of HSA-PCB153 system. Molecular docking revealed PCB153 can bind in a large hydrophobic activity of subdomain IIIA by the hydrophobic interaction and hydrogen bond interactions between chlorine atoms and residue ASN391. The present work provided reasonable models helping us further understand the transporting, distribution and toxicity effect of PCBs when it spread into human blood serum.

Application of Molecular Modeling to Urokinase Inhibitors Development

Directory of Open Access Journals (Sweden)

V. B. Sulimov

2014-01-01

Full Text Available Urokinase-type plasminogen activator (uPA plays an important role in the regulation of diverse physiologic and pathologic processes. Experimental research has shown that elevated uPA expression is associated with cancer progression, metastasis, and shortened survival in patients, whereas suppression of proteolytic activity of uPA leads to evident decrease of metastasis. Therefore, uPA has been considered as a promising molecular target for development of anticancer drugs. The present study sets out to develop the new selective uPA inhibitors using computer-aided structural based drug design methods. Investigation involves the following stages: computer modeling of the protein active site, development and validation of computer molecular modeling methods: docking (SOL program, postprocessing (DISCORE program, direct generalized docking (FLM program, and the application of the quantum chemical calculations (MOPAC package, search of uPA inhibitors among molecules from databases of ready-made compounds to find new uPA inhibitors, and design of new chemical structures and their optimization and experimental examination. On the basis of known uPA inhibitors and modeling results, 18 new compounds have been designed, calculated using programs mentioned above, synthesized, and tested in vitro. Eight of them display inhibitory activity and two of them display activity about 10 μM.

Naumovozyma castellii: an alternative model for budding yeast molecular biology.

Science.gov (United States)

Karademir Andersson, Ahu; Cohn, Marita

2017-03-01

Naumovozyma castellii (Saccharomyces castellii) is a member of the budding yeast family Saccharomycetaceae. It has been extensively used as a model organism for telomere biology research and has gained increasing interest as a budding yeast model for functional analyses owing to its amenability to genetic modifications. Owing to the suitable phylogenetic distance to S. cerevisiae, the whole genome sequence of N. castellii has provided unique data for comparative genomic studies, and it played a key role in the establishment of the timing of the whole genome duplication and the evolutionary events that took place in the subsequent genomic evolution of the Saccharomyces lineage. Here we summarize the historical background of its establishment as a laboratory yeast species, and the development of genetic and molecular tools and strains. We review the research performed on N. castellii, focusing on areas where it has significantly contributed to the discovery of new features of molecular biology and to the advancement of our understanding of molecular evolution. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

The chaos and order in nuclear molecular dynamics

International Nuclear Information System (INIS)

Srokowski, T.

1995-01-01

The subject of the presented report is role of chaos in scattering processes in the frame of molecular dynamics. In this model, it is assumed that scattering particles (nuclei) consist of not-interacted components as alpha particles or 12 C, 16 O and 20 Ne clusters. The results show such effects as dynamical in stabilities and fractal structure as well as compound nuclei decay and heavy-ion fusion. The goal of the report is to make the reader more familiar with the chaos model and its application to nuclear phenomena. 157 refs, 40 figs

Molecular Models for DSMC Simulations of Metal Vapor Deposition

OpenAIRE

Venkattraman, A; Alexeenko, Alina A

2010-01-01

The direct simulation Monte Carlo (DSMC) method is applied here to model the electron‐beam (e‐beam) physical vapor deposition of copper thin films. A suitable molecular model for copper‐copper interactions have been determined based on comparisons with experiments for a 2D slit source. The model for atomic copper vapor is then used in axi‐symmetric DSMC simulations for analysis of a typical e‐beam metal deposition system with a cup crucible. The dimensional and non‐dimensional mass fluxes obt...

76 FR 37684 - Airworthiness Directives; Diamond Aircraft Industries GmbH Model (Diamond) DA 40 Airplanes...

Science.gov (United States)

2011-06-28

... Industries GmbH Model (Diamond) DA 40 Airplanes Equipped With Certain Cabin Air Conditioning Systems AGENCY... inspections of the Diamond Model DA 40 airplanes equipped with a VCS installed per Premier Aircraft Service... GmbH Model (Diamond) DA 40 Airplanes Equipped With Certain Cabin Air Conditioning Systems: Docket No...

A New Critical State Model for Geomechanical Behavior of Methane Hydrate-Bearing Sands

Science.gov (United States)

Lin, J. S.; Xing, P.; Rutqvist, J.; Seol, Y.; Choi, J. H.

2014-12-01

Methane hydrate bearing sands behave like sands once the hydrate has dissociated, but could exhibit a substantial increase in the shear strength, stiffness and dilatancy as the degree of hydrate saturation increases. A new critical state model was developed that incorporates the spatially mobilized plane (SMP) concept, which has been proven effective in modeling mechanical behavior of sands. While this new model was built on the basic constructs of the critical state model, important enhancements were introduced. The model adopted the t-stress concept, which defined the normal and shear stress on the SMP, in describing the plastic behavior of the soil. In this connection the versatile Matsuoka-Nakai yield criterion was also employed, which defined the general three dimensional yield behavior. The resulting constitutive law was associated in the t-stress space, but became non-associated in the conventional p-q stress space as it should be for sands. The model also introduced a generalized degree of hydrate saturation concept that was modified from the pioneering work of the Cambridge group. The model gives stress change when the sands are subjected to straining, and/or to hydrate saturation changes. The performance of the model has been found satisfactory using data from laboratory triaxial tests on reconstituted samples and core samples taken from Nankai Trough, Japan. The model has been implemented into FLAC3D. A coupling example with the multiphase flow code, TOUGH+, is presented which simulates the mechanical behavior of a sample when the surrounding temperature has been raised, and the hydrate undergoes state change and no longer resides in the stability zone.

Molecular modeling of polycarbonate materials: Glass transition and mechanical properties

Science.gov (United States)

Palczynski, Karol; Wilke, Andreas; Paeschke, Manfred; Dzubiella, Joachim

2017-09-01

Linking the experimentally accessible macroscopic properties of thermoplastic polymers to their microscopic static and dynamic properties is a key requirement for targeted material design. Classical molecular dynamics simulations enable us to study the structural and dynamic behavior of molecules on microscopic scales, and statistical physics provides a framework for relating these properties to the macroscopic properties. We take a first step toward creating an automated workflow for the theoretical prediction of thermoplastic material properties by developing an expeditious method for parameterizing a simple yet surprisingly powerful coarse-grained bisphenol-A polycarbonate model which goes beyond previous coarse-grained models and successfully reproduces the thermal expansion behavior, the glass transition temperature as a function of the molecular weight, and several elastic properties.

Molecular mechanisms in compatibility and mechanical properties of Polyacrylamide/Polyvinyl alcohol blends.

Science.gov (United States)

Wei, Qinghua; Wang, Yanen; Che, Yu; Yang, Mingming; Li, Xinpei; Zhang, Yingfeng

2017-01-01

The objectives of this study were to develop a computational model based on molecular dynamics technique to investigate the compatibility and mechanical properties of Polyacrylamide (PAM)/Polyvinyl alcohol (PVA) blends. Five simulation models of PAM/PVA with different composition ratios (4/0, 3/1, 2/2, 1/3, 0/4) were constructed and simulated by using molecular dynamics (MD) simulation. The interaction mechanisms of molecular chains in PAM/PVA blend system were elaborated from the aspects of the compatibility, mechanical properties, binding energy and pair correlation function, respectively. The computed values of solubility parameters for PAM and PVA indicate PAM has a good miscibility with PVA. The results of the static mechanical analysis, based on the equilibrium structures of blends with differing component ratios, shows us that the elastic coefficient, engineering modulus, and ductility are increased with the addition of PVA content, which is 4/0 PAM/PVAPVAPVAPVAPVA. Moreover, binding energy results indicate that a stronger interaction exists among PVA molecular chains comparing with PAM molecular chains, which is why the mechanical properties of blend system increasing with the addition of PVA content. Finally, the results of pair correlation functions (PCFs) between polar functional groups and its surrounding hydrogen atoms, indicated they interact with each other mainly by hydrogen bonds, and the strength of three types of polar functional groups has the order of O(-OH)>O(-C=O)>N(-NH 2 ). This further elaborates the root reason why the mechanical properties of blend system increase with the addition of PVA content. Copyright © 2016 Elsevier Ltd. All rights reserved.

Molecular Mechanism of Gastric Carcinogenesis in Helicobacter pylori-Infected Rodent Models

Directory of Open Access Journals (Sweden)

Takeshi Toyoda

2014-06-01

Full Text Available Since the discovery of Helicobacter pylori (H. pylori, many efforts have been made to establish animal models for the investigation of the pathological features and molecular mechanisms of gastric carcinogenesis. Among the animal models, Mongolian gerbils and mice are particularly useful for the analysis of H. pylori-associated inflammatory reactions and gastric cancer development. Inhibitors of oxidative stress, cyclooxygenase-2 (COX-2 and nuclear factor-κB, exert preventive effects on chronic gastritis and the development of adenocarcinomas in H. pylori-infected gerbils. Genetically-modified mouse models, including transgenic and knockout mice, have also revealed the importance of p53, COX-2/prostaglandin, Wnt/β-catenin, proinflammatory cytokines, gastrin and type III mucin in the molecular mechanisms of gastric carcinogenesis. Microarray technology is available for comprehensive gene analysis in the gastric mucosa of mouse models, and epigenetics, such as DNA methylation, could be an alternative approach to correlate the observations in animal models with the etiology in humans.

Direct calculation of ice homogeneous nucleation rate for a molecular model of water

Science.gov (United States)

Haji-Akbari, Amir; Debenedetti, Pablo G.

2015-01-01

Ice formation is ubiquitous in nature, with important consequences in a variety of environments, including biological cells, soil, aircraft, transportation infrastructure, and atmospheric clouds. However, its intrinsic kinetics and microscopic mechanism are difficult to discern with current experiments. Molecular simulations of ice nucleation are also challenging, and direct rate calculations have only been performed for coarse-grained models of water. For molecular models, only indirect estimates have been obtained, e.g., by assuming the validity of classical nucleation theory. We use a path sampling approach to perform, to our knowledge, the first direct rate calculation of homogeneous nucleation of ice in a molecular model of water. We use TIP4P/Ice, the most accurate among existing molecular models for studying ice polymorphs. By using a novel topological approach to distinguish different polymorphs, we are able to identify a freezing mechanism that involves a competition between cubic and hexagonal ice in the early stages of nucleation. In this competition, the cubic polymorph takes over because the addition of new topological structural motifs consistent with cubic ice leads to the formation of more compact crystallites. This is not true for topological hexagonal motifs, which give rise to elongated crystallites that are not able to grow. This leads to transition states that are rich in cubic ice, and not the thermodynamically stable hexagonal polymorph. This mechanism provides a molecular explanation for the earlier experimental and computational observations of the preference for cubic ice in the literature. PMID:26240318

Prediction of mechanical properties for hexagonal boron nitride nanosheets using molecular mechanics model

Energy Technology Data Exchange (ETDEWEB)

Natsuki, Toshiaki [Shinshu University, Faculty of Textile Science and Technology, Ueda (Japan); Shinshu University, Institute of Carbon Science and Technology, Nagano (Japan); Natsuki, Jun [Shinshu University, Institute of Carbon Science and Technology, Nagano (Japan)

2017-04-15

Mechanical behaviors of nanomaterials are not easy to be evaluated in the laboratory because of their extremely small size and difficulty controlling. Thus, a suitable model for the estimation of the mechanical properties for nanomaterials becomes very important. In this study, the elastic properties of boron nitride (BN) nanosheets, including the elastic modulus, the shear modulus, and the Poisson's ratio, are predicted using a molecular mechanics model. The molecular mechanics force filed is established to directly incorporate the Morse potential function into the constitutive model of nanostructures. According to the molecular mechanics model, the chirality effect of hexagonal BN nanosheets on the elastic modulus is investigated through a closed-form solution. The simulated result shows that BN nanosheets exhibit an isotropic elastic property. The present analysis yields a set of very simple formulas and is able to be served as a good approximation on the mechanical properties for the BN nanosheets. (orig.)

Prediction of mechanical properties for hexagonal boron nitride nanosheets using molecular mechanics model

International Nuclear Information System (INIS)

Natsuki, Toshiaki; Natsuki, Jun

2017-01-01

Mechanical behaviors of nanomaterials are not easy to be evaluated in the laboratory because of their extremely small size and difficulty controlling. Thus, a suitable model for the estimation of the mechanical properties for nanomaterials becomes very important. In this study, the elastic properties of boron nitride (BN) nanosheets, including the elastic modulus, the shear modulus, and the Poisson's ratio, are predicted using a molecular mechanics model. The molecular mechanics force filed is established to directly incorporate the Morse potential function into the constitutive model of nanostructures. According to the molecular mechanics model, the chirality effect of hexagonal BN nanosheets on the elastic modulus is investigated through a closed-form solution. The simulated result shows that BN nanosheets exhibit an isotropic elastic property. The present analysis yields a set of very simple formulas and is able to be served as a good approximation on the mechanical properties for the BN nanosheets. (orig.)

Molecularly Imprinted Membranes

Science.gov (United States)

Trotta, Francesco; Biasizzo, Miriam; Caldera, Fabrizio

2012-01-01

Although the roots of molecularly imprinted polymers lie in the beginning of 1930s in the past century, they have had an exponential growth only 40–50 years later by the works of Wulff and especially by Mosbach. More recently, it was also proved that molecular imprinted membranes (i.e., polymer thin films) that show recognition properties at molecular level of the template molecule are used in their formation. Different procedures and potential application in separation processes and catalysis are reported. The influences of different parameters on the discrimination abilities are also discussed. PMID:24958291

Animal models and therapeutic molecular targets of cancer: utility and limitations

Directory of Open Access Journals (Sweden)

Cekanova M

2014-10-01

Full Text Available Maria Cekanova, Kusum Rathore Department of Small Animal Clinical Sciences, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN, USA Abstract: Cancer is the term used to describe over 100 diseases that share several common hallmarks. Despite prevention, early detection, and novel therapies, cancer is still the second leading cause of death in the USA. Successful bench-to-bedside translation of basic scientific findings about cancer into therapeutic interventions for patients depends on the selection of appropriate animal experimental models. Cancer research uses animal and human cancer cell lines in vitro to study biochemical pathways in these cancer cells. In this review, we summarize the important animal models of cancer with focus on their advantages and limitations. Mouse cancer models are well known, and are frequently used for cancer research. Rodent models have revolutionized our ability to study gene and protein functions in vivo and to better understand their molecular pathways and mechanisms. Xenograft and chemically or genetically induced mouse cancers are the most commonly used rodent cancer models. Companion animals with spontaneous neoplasms are still an underexploited tool for making rapid advances in human and veterinary cancer therapies by testing new drugs and delivery systems that have shown promise in vitro and in vivo in mouse models. Companion animals have a relatively high incidence of cancers, with biological behavior, response to therapy, and response to cytotoxic agents similar to those in humans. Shorter overall lifespan and more rapid disease progression are factors contributing to the advantages of a companion animal model. In addition, the current focus is on discovering molecular targets for new therapeutic drugs to improve survival and quality of life in cancer patients. Keywords: mouse cancer model, companion animal cancer model, dogs, cats, molecular targets

MOLECULAR VALIDATED MODEL FOR ADSORPTION OF PROTONATED DYE ON LDH

Directory of Open Access Journals (Sweden)

B. M. Braga

Full Text Available Abstract Hydrotalcite-like compounds are anionic clays of scientific and technological interest for their use as ion exchange materials, catalysts and modified electrodes. Surface phenomenon are important for all these applications. Although conventional analytical methods have enabled progress in understanding the behavior of anionic clays in solution, an evaluation at the atomic scale of the dynamics of their ionic interactions has never been performed. Molecular simulation has become an extremely useful tool to provide this perspective. Our purpose is to validate a simplified model for the adsorption of 5-benzoyl-4-hydroxy-2-methoxy-benzenesulfonic acid (MBSA, a prototype molecule of anionic dyes, onto a hydrotalcite surface. Monte Carlo simulations were performed in the canonical ensemble with MBSA ions and a pore model of hydrotalcite using UFF and ClayFF force fields. The proposed molecular model has allowed us to reproduce experimental data of atomic force microscopy. Influences of protonation during the adsorption process are also presented.

Exploring the boundaries of molecular modeling : a study of nanochannels and transmembrane proteins

NARCIS (Netherlands)

Spijker, P.

2009-01-01

Many interesting physical and biological phenomena can be investigated using molecular modeling techniques, either theoretically or by using computer simulation methods, such as molecular dynamics and Monte Carlo simulations. Due to the increasing power of computer processing units, these simulation

Computer aided molecular design with combined molecular modeling and group contribution

DEFF Research Database (Denmark)

Harper, Peter Mathias; Gani, Rafiqul; Kolar, Petr

1999-01-01

Computer-aided molecular design (CAMD) provides a means for determining molecules or mixtures of molecules (CAMMD) having a desirable set of physicochemical properties. The application range of CAMD is restricted due to limitations on the complexity of the generated molecular structures and on th......Computer-aided molecular design (CAMD) provides a means for determining molecules or mixtures of molecules (CAMMD) having a desirable set of physicochemical properties. The application range of CAMD is restricted due to limitations on the complexity of the generated molecular structures...

Molecular modeling of human neutral sphingomyelinase provides insight into its molecular interactions.

Science.gov (United States)

Dinesh; Goswami, Angshumala; Suresh, Panneer Selvam; Thirunavukkarasu, Chinnasamy; Weiergräber, Oliver H; Kumar, Muthuvel Suresh

2011-01-01

The neutral sphingomyelinase (N-SMase) is considered a major candidate for mediating the stress-induced production of ceramide, and it plays an important role in cell-cycle arrest, apoptosis, inflammation, and eukaryotic stress responses. Recent studies have identified a small region at the very N-terminus of the 55 kDa tumour necrosis factor receptor (TNF-R55), designated the neutral sphingomyelinase activating domain (NSD) that is responsible for the TNF-induced activation of N-SMase. There is no direct association between TNF-R55 NSD and N-SMase; instead, a protein named factor associated with N-SMase activation (FAN) has been reported to couple the TNF-R55 NSD to N-SMase. Since the three-dimensional fold of N-SMase is still unknown, we have modeled the structure using the protein fold recognition and threading method. Moreover, we propose models for the TNF-R55 NSD as well as the FAN protein in order to study the structural basis of N-SMase activation and regulation. Protein-protein interaction studies suggest that FAN is crucially involved in mediating TNF-induced activation of the N-SMase pathway, which in turn regulates mitogenic and proinflammatory responses. Inhibition of N-SMase may lead to reduction of ceramide levels and hence may provide a novel therapeutic strategy for inflammation and autoimmune diseases. Molecular dynamics (MD) simulations were performed to check the stability of the predicted model and protein-protein complex; indeed, stable RMS deviations were obtained throughout the simulation. Furthermore, in silico docking of low molecular mass ligands into the active site of N-SMase suggests that His135, Glu48, Asp177, and Asn179 residues play crucial roles in this interaction. Based on our results, these ligands are proposed to be potent and selective N-SMase inhibitors, which may ultimately prove useful as lead compounds for drug development.

Modeling the Thiophene HDS reaction on a molecular level

NARCIS (Netherlands)

Diemann, E.; Weber, T.; Müller, A.

1994-01-01

The structure of MoS2/Al2O3 catalyst and the initial step of the hydrodesulfurization (HDS) reaction using an experimental model have been studied by in situ Raman-, infrared emission (IRE)-, inelastic electron tunneling (IET)-spectroscopy and thermal desorption measurements accompanied by molecular

Molecular models of alginic acid: Interactions with calcium ions and calcite surfaces

Science.gov (United States)

Perry, Thomas D.; Cygan, Randall T.; Mitchell, Ralph

2006-07-01

Cation binding by polysaccharides is observed in many environments and is important for predictive environmental modeling, and numerous industrial and food technology applications. The complexities of these cation-organic interactions are well suited for predictive molecular modeling and the analysis of conformation and configuration of polysaccharides and their influence on cation binding. In this study, alginic acid was chosen as a model polymer system and representative disaccharide and polysaccharide subunits were developed. Molecular dynamics simulation of the torsion angles of the ether linkage between various monomeric subunits identified local and global energy minima for selected disaccharides. The simulations indicate stable disaccharide configurations and a common global energy minimum for all disaccharide models at Φ = 274 ± 7°, Ψ = 227 ± 5°, where Φ and Ψ are the torsion angles about the ether linkage. The ability of disaccharide subunits to bind calcium ions and to associate with the (101¯4) surface of calcite was also investigated. Molecular models of disaccharide interactions with calcite provide binding energy differences for conformations that are related to the proximity and residence densities of the electron-donating moieties with calcium ions on the calcite surface, which are controlled, in part, by the torsion of the ether linkage between monosaccharide units. Dynamically optimized configurations for polymer alginate models with calcium ions were also derived.

PENERAPAN MODEL PEMBELAJARAN TIPE CIRC UNTUK MENINGKATKAN HASIL BELAJAR MATEMATIKA

Directory of Open Access Journals (Sweden)

Lina Salantina

2018-01-01

Full Text Available Keberhasilan belajar matematika, salah satunya ditentukan oleh minat siswa, dan untuk membangkitkan minat siswa tersebut ditentukan oleh kemampuan guru dalam menggunakan pendekatan mengajarnya yang dapat mengakibatkan siswa lebih tertarik, mengerti, berperan serta aktif, mencari dan menemukan sendiri. Untuk bahan penelitian, pokok bahasan yang diambil adalah perbandingan senilai (seharga dan perbandingan berbalik nilai (berbalik harga. Dengan menerapkan model pembelajaran Cooperative Learning tipe Cooperative Integrated Reading and Composition (CIRC,ternyata hasil belajar dapat meningkat bila dibandingkan dengan hasil belajar sebelumnya.Hal ini diduga karena guru kurang tepat dalam mengambil model pembelajaran untuk materi tersebut. Permasalahan yang diangkat pada penelitian ini adalah apakah penggunaan model pembelajaran Cooperative Learning Tipe Cooperative Integrated Reading And Composition (CIRC dapat meningkatkan hasil belajar siswa pada pokok bahasan perbandingan. Subyek penelitian ini adalah siswa kelas VII B SMP Negeri 3 Kuningan tahun pelajaran 2015/2016, dengan jumlah siswa 40 orang yang terdiri dari 18 siswa putri, dan 22 siswa putra. Prosedur tindakan kelas ini ditempuh dalam 3 siklus. Langkah-langkah siklus terdiri dari perencanaan, tindakan, pengamatan, dan refleksi. Cara pengambilan data dalam penelitian ini dengan menggunakan tes, penilaian kinerja, dan observasi. Sebagai tolok ukur keberhasilan adalah nilai rata-rata silkus I, II, dan III berturut-turut 63,4, 63,0, 65,6 dan ketuntasan belajar klasikal berturut-turut 72,5%, 67,5%, dan 80,0%. Simpulan yang dapat peneliti ambil adalah penggunaan Model Pembelajaran Cooperative Learning Tipe Cooperative Integrated Reading And Compositon (CIRC dapat meningkatkan hasil belajar. Sedangkan peneliti menyarankan guru hendaknya menggunakan model pembelajaran ini untuk pokok-pokok bahasan perbandingan. Kata kunci: Penerapan Model Pembelajaran Tipe CIRC.

76 FR 72087 - Special Conditions: Diamond Aircraft Industries, Model DA-40NG; Electronic Engine Control (EEC...

Science.gov (United States)

2011-11-22

...; Special Conditions No. 23-253-SC] Special Conditions: Diamond Aircraft Industries, Model DA-40NG..., Model DA-40NG airplane. This airplane will have a novel or unusual design feature(s) associated with an... include the new model DA- 40NG with the Austro Engine GmbH model E4 Aircraft Diesel Engine (ADE). The...

Improving a Lecture-Size Molecular Model Set by Repurposing Used Whiteboard Markers

Science.gov (United States)

Dragojlovic, Veljko

2015-01-01

Preparation of an inexpensive model set from whiteboard markers and either HGS molecular model set or atoms made of wood is described. The model set is relatively easy to prepare and is sufficiently large to be suitable as an instructor set for use in lectures.

Metal cluster fission: jellium model and Molecular dynamics simulations

DEFF Research Database (Denmark)

Lyalin, Andrey G.; Obolensky, Oleg I.; Solov'yov, Ilia

2004-01-01

Fission of doubly charged sodium clusters is studied using the open-shell two-center deformed jellium model approximation and it ab initio molecular dynamic approach accounting for all electrons in the system. Results of calculations of fission reactions Na_10^2+ --> Na_7^+ + Na_3^+ and Na_18...

A Self-Assisting Protein Folding Model for Teaching Structural Molecular Biology.

Science.gov (United States)

Davenport, Jodi; Pique, Michael; Getzoff, Elizabeth; Huntoon, Jon; Gardner, Adam; Olson, Arthur

2017-04-04

Structural molecular biology is now becoming part of high school science curriculum thus posing a challenge for teachers who need to convey three-dimensional (3D) structures with conventional text and pictures. In many cases even interactive computer graphics does not go far enough to address these challenges. We have developed a flexible model of the polypeptide backbone using 3D printing technology. With this model we have produced a polypeptide assembly kit to create an idealized model of the Triosephosphate isomerase mutase enzyme (TIM), which forms a structure known as TIM barrel. This kit has been used in a laboratory practical where students perform a step-by-step investigation into the nature of protein folding, starting with the handedness of amino acids to the formation of secondary and tertiary structure. Based on the classroom evidence we collected, we conclude that these models are valuable and inexpensive resource for teaching structural molecular biology. Copyright © 2017 Elsevier Ltd. All rights reserved.

Inclusion Complexes of Sunscreen Agents with β-Cyclodextrin: Spectroscopic and Molecular Modeling Studies

Directory of Open Access Journals (Sweden)

Nathir A. F. Al-Rawashdeh

2013-01-01

Full Text Available The inclusion complexes of selected sunscreen agents, namely, oxybenzone (Oxy, octocrylene (Oct, and ethylhexyl-methoxycinnamate (Cin with β-cyclodextrin (β-CD were studied by UV-Vis spectroscopy, differential scanning calorimetry (DSC, 13C NMR techniques, and molecular mechanics (MM calculations and modeling. Molecular modeling (MM study of the entire process of the formation of 1 : 1 stoichiometry sunscreen agent/β-cyclodextrin structures has been used to contribute to the understanding and rationalization of the experimental results. Molecular mechanics calculations, together with 13C NMR measurements, for the complex with β-CD have been used to describe details of the structural, energetic, and dynamic features of host-guest complex. Accurate structures of CD inclusion complexes have been derived from molecular mechanics (MM calculations and modeling. The photodegradation reaction of the sunscreen agents' molecules in lotion was explored using UV-Vis spectroscopy. It has been demonstrated that the photostability of these selected sunscreen agents has been enhanced upon forming inclusion complexes with β-CD in lotion. The results of this study demonstrate that β-CD can be utilized as photostabilizer additive for enhancing the photostability of the selected sunscreen agents' molecules.

A Stochastic Maximum Principle for Risk-Sensitive Mean-Field Type Control

KAUST Repository

Djehiche, Boualem; Tembine, Hamidou; Tempone, Raul

2015-01-01

In this paper we study mean-field type control problems with risk-sensitive performance functionals. We establish a stochastic maximum principle (SMP) for optimal control of stochastic differential equations (SDEs) of mean-field type, in which the drift and the diffusion coefficients as well as the performance functional depend not only on the state and the control but also on the mean of the distribution of the state. Our result extends the risk-sensitive SMP (without mean-field coupling) of Lim and Zhou (2005), derived for feedback (or Markov) type optimal controls, to optimal control problems for non-Markovian dynamics which may be time-inconsistent in the sense that the Bellman optimality principle does not hold. In our approach to the risk-sensitive SMP, the smoothness assumption on the value-function imposed in Lim and Zhou (2005) needs not be satisfied. For a general action space a Peng's type SMP is derived, specifying the necessary conditions for optimality. Two examples are carried out to illustrate the proposed risk-sensitive mean-field type SMP under linear stochastic dynamics with exponential quadratic cost function. Explicit solutions are given for both mean-field free and mean-field models.

HUBUNGAN ANTARA POLA ASUH ORANG TUA DAN KETAATAN BERIBADAH DENGAN PERILAKU SOPAN SANTUN PESERTA DIDIK

Directory of Open Access Journals (Sweden)

Putri Risthantri

2015-09-01

Full Text Available Penelitian ini bertujuan untuk: (1 mengetahui hubungan antara pola asuh orang tua dengan perilaku sopan santun peserta didik; (2 mengetahui hubungan antara ketaatan beribadah dengan perilaku sopan santun peserta didik; ( 3 mengetahui hubungan antara pola asuh orang tua dan ketaatan beribadah secara bersama-sama dengan perilaku sopan santun peserta didik di SMP Negeri se Kecamatan Ngaglik Kabupaten Sleman. Penelitian ini merupakan jenis penelitian kuantitatif dengan desain korelasional. Penelitian dilaksanakan di SMP Negeri 1, SMP Negeri 2, SMP Negeri 3, dan SMP Negeri 4 Kecamatan Ngaglik Kabupaten Sleman. Penelitian dilaksanakan pada bulan Oktober 2014 sampai Juni 2015. Populasi sebanyak 1.767 siswa. Sampel diambil secara simple random sampling. Data dikumpulkan melalui angket. Uji validitas menggunakan validitas konstrak dengan model Confirmatory Factor Analysis (CFA. Analisis data meliputi analisis deskriptif, pengujian persyaratan analisis, dan pengujian hipotesis. Hasil penelitian menunjukkan bahwa: (1 ada hubungan yang positif dan signifikan antara pola asuh orang tua dengan perilaku sopan santun peserta didik; (2 ada hubungan yang positif dan signifikan antara ketaatan beribadah dengan perilaku sopan santun peserta didik; (3 ada hubungan yang positif dan signifikan antara pola asuh orang tua dan ketaatan beribadah secara bersama-sama dengan perilaku sopan santun peserta didik.

A Stochastic Maximum Principle for Risk-Sensitive Mean-Field Type Control

KAUST Repository

Djehiche, Boualem

2015-02-24

In this paper we study mean-field type control problems with risk-sensitive performance functionals. We establish a stochastic maximum principle (SMP) for optimal control of stochastic differential equations (SDEs) of mean-field type, in which the drift and the diffusion coefficients as well as the performance functional depend not only on the state and the control but also on the mean of the distribution of the state. Our result extends the risk-sensitive SMP (without mean-field coupling) of Lim and Zhou (2005), derived for feedback (or Markov) type optimal controls, to optimal control problems for non-Markovian dynamics which may be time-inconsistent in the sense that the Bellman optimality principle does not hold. In our approach to the risk-sensitive SMP, the smoothness assumption on the value-function imposed in Lim and Zhou (2005) needs not be satisfied. For a general action space a Peng\\'s type SMP is derived, specifying the necessary conditions for optimality. Two examples are carried out to illustrate the proposed risk-sensitive mean-field type SMP under linear stochastic dynamics with exponential quadratic cost function. Explicit solutions are given for both mean-field free and mean-field models.

BUDAYA KERJA GURU PENDIDIKAN DASAR UNGGUL (Studi Situs SMP Negeri 1 Gunung Jati Cirebon

Directory of Open Access Journals (Sweden)

Sri Handayani

2015-07-01

Full Text Available This study is aimed at describing the working culture of administration, teaching learning activities, and evaluating the teaching learning process of accelerated class of SMP 1 Gunung Jati Cirebon teachers in doing their job. This study applies the qualitative of ethnographic that is to see directly the working culture of the subject of the study such as their behavior, their motivation, their perception and their action related to good teachers working culture. The data are taken from interviews with teachers, documents related of teachers job, and field study. In collecting the data, the researcher carried our interview with teachers, doing some observations, and study the documents related to teachers’ job. The data are analyzed and tested using credibility, dependability, and confirm ability tests.The results of the study are: (1 the teachers working culture in doing their administrative means how a teacher increases work such as developing syllabus, making lesson plan, developing indicators, and developing teachers materials. Teachers’ working culture in developing their administration work are developed in school and region teacher forum; (2 teachers working culture in teaching learning activities means how teacher increases work such as make, introduction activity, core activity, and final activity in the teaching and learning process as indicated by the curriculum. (3 teachers working culture in evaluating the teaching learning process means how teacher increases work such as compilation planning of assessment and execution of assessment. The study suggests: (1 the headmaster should give opportunities for teacher to develop their work so that they can contribute to the administration, classroom teaching learning process, evaluation and analysis; (2 the teachers can improve their work such as the administration, classroom teaching learning process, and evaluation of study with activities or constructions by school, duty education

Molecular and multiscale modeling: review on the theories and applications in chemical engineering

International Nuclear Information System (INIS)

Morales M, Giovanni; Martinez R, Ramiro

2010-01-01

We call molecular modeling to the application of suitable laws in the analysis of phenomena occurred at scales less than those accounted for by the macroscopic world. Such different scales (including micro-, meso- and macro scales), can be linked and integrated in order to improve understanding and predictions of complex physical chemistry phenomena, thus originating a global or multi scale analysis. A considerable amount of chemical engineering phenomena are complex due to the interrelation among these different realms of length and time. Multi scale modeling rises as an alternative for an outstanding mathematical and conceptual representation of such phenomena. This adequate representation may help to design and optimize chemical and petrochemical processes from a microscopic point of view. Herein we present a brief introduction to both molecular and multi scale modeling methods. We also comment and examine opportunities for applying the different levels of modeling to the analysis of industrial problems. The fundamental mathematical machinery of the molecular modelling theories is presented in order to motivate the study of these new engineering tools. Finally, we show a classification of different strategies for applying multilevel analysis, illustrating various examples of each methodology.

Molecular dynamics simulations of site point mutations in the TPR domain of cyclophilin 40 identify conformational states with distinct dynamic and enzymatic properties

Science.gov (United States)

Gur, Mert; Blackburn, Elizabeth A.; Ning, Jia; Narayan, Vikram; Ball, Kathryn L.; Walkinshaw, Malcolm D.; Erman, Burak

2018-04-01

Cyclophilin 40 (Cyp40) is a member of the immunophilin family that acts as a peptidyl-prolyl-isomerase enzyme and binds to the heat shock protein 90 (Hsp90). Its structure comprises an N-terminal cyclophilin domain and a C-terminal tetratricopeptide (TPR) domain. Cyp40 is overexpressed in prostate cancer and certain T-cell lymphomas. The groove for Hsp90 binding on the TPR domain includes residues Lys227 and Lys308, referred to as the carboxylate clamp, and is essential for Cyp40-Hsp90 binding. In this study, the effect of two mutations, K227A and K308A, and their combinative mutant was investigated by performing a total of 5.76 μs of all-atom molecular dynamics (MD) simulations in explicit solvent. All simulations, except the K308A mutant, were found to adopt two distinct (extended or compact) conformers defined by different cyclophilin-TPR interdomain distances. The K308A mutant was only observed in the extended form which is observed in the Cyp40 X-ray structure. The wild-type, K227A, and combined mutant also showed bimodal distributions. The experimental melting temperature, Tm, values of the mutants correlate with the degree of compactness with the K308A extended mutant having a marginally lower melting temperature. Another novel measure of compactness determined from the MD data, the "coordination shell volume," also shows a direct correlation with Tm. In addition, the MD simulations show an allosteric effect with the mutations in the remote TPR domain having a pronounced effect on the molecular motions of the enzymatic cyclophilin domain which helps rationalise the experimentally observed increase in enzyme activity measured for all three mutations.

A molecular-thermodynamic model for polyelectrolyte solutions

Energy Technology Data Exchange (ETDEWEB)

Jiang, J.; Liu, H.; Hu, Y. [Thermodynamics Research Laboratory, East China University of Science and Technology, Shanghai 200237 (China); Prausnitz, J.M. [Department of Chemical Engineering, University of California, Berkeley, and Chemical Sciences Division, Lawrence Berkeley Laboratory, University of California, Berkeley, California 94720 (United States)

1998-01-01

Polyelectrolyte solutions are modeled as freely tangent-jointed, charged hard-sphere chains and corresponding counterions in a continuum medium with permitivity {var_epsilon}. By adopting the sticky-point model, the Helmholtz function for polyelectrolyte solutions is derived through the r-particle cavity-correlation function (CCF) for chains of sticky, charged hard spheres. The r-CCF is approximated by a product of effective nearest-neighbor two-particle CCFs; these are determined from the hypernetted-chain and mean-spherical closures (HNC/MSA) inside and outside the hard core, respectively, for the integral equation theory for electrolytes. The colligative properties are given as explicit functions of a scaling parameter {Gamma} that can be estimated by a simple iteration procedure. Osmotic pressures, osmotic coefficients, and activity coefficients are calculated for model solutions with various chain lengths. They are in good agreement with molecular simulation and experimental results. {copyright} {ital 1998 American Institute of Physics.}

Interaction of methotrexate with trypsin analyzed by spectroscopic and molecular modeling methods

Science.gov (United States)

Wang, Yanqing; Zhang, Hongmei; Cao, Jian; Zhou, Qiuhua

2013-11-01

Trypsin is one of important digestive enzymes that have intimate correlation with human health and illness. In this work, the interaction of trypsin with methotrexate was investigated by spectroscopic and molecular modeling methods. The results revealed that methotrexate could interact with trypsin with about one binding site. Methotrexate molecule could enter into the primary substrate-binding pocket, resulting in inhibition of trypsin activity. Furthermore, the thermodynamic analysis implied that electrostatic force, hydrogen bonding, van der Waals and hydrophobic interactions were the main interactions for stabilizing the trypsin-methotrexate system, which agreed well with the results from the molecular modeling study.

THE INFLUENCE OF THE ASSESSMENT MODEL AND METHOD TOWARD THE SCIENCE LEARNING ACHIEVEMENT BY CONTROLLING THE STUDENTS? PREVIOUS KNOWLEDGE OF MATHEMATICS.

OpenAIRE

Adam rumbalifar; I. g. n. Agung; Burhanuddin tola.

2018-01-01

This research aims to study the influence of the assessment model and method toward the science learning achievement by controlling the students? previous knowledge of mathematics. This study was conducted at SMP East Seram district with the population of 295 students. This study applied a quasi-experimental method with 2 X 2 factorial design using the ANCOVA model. The findings after controlling the students\\' previous knowledge of mathematics show that the science learning achievement of th...

Hypoglycemic effect of polysaccharides with different molecular weight of Pseudostellaria heterophylla

Science.gov (United States)

2013-01-01

Abstracts Background The aims of this study were to evaluate the antidiabetic activity and to detect molecular size of Pseudostellaria heterophylla polysaccharide (PHP). Pseudostellaria heterophylla is a medicine extensively used in traditional Chinese medicine formulas to treat diabetes and its complications. Methods Molecular weight of PHP was determined by gel permeation chromatography combined with phenol-sulphuric acid method and the monosaccharides composition was determined by HPLC with a precolumn derivatization. Four polysaccharides with different molecular weight were compared for hypoglycemic active on two animal models both high does alloxan induced type1 diabetic mellitus (T1DM) and high-fat/lower does streptozotocin induced type2 diabetic mellitus (T2DM). Blood sugar, glucose tolerance, and insulin tolerance were detected. Rat serum IL-1β, IL-2, IL-10, Leptin, TNF-α, Acrp30 and CRP were also analyzed by sandwich-ELISA approaches to preliminary probe the hypoglycemic mechanism of PHP. Results The hypoglycemic effects related to molecular size of polysaccharide were more effective against T2DM than T1DM. PHP comprise four monosaccharides of galacturonic acid, glucose, galactose and arabinos. T2DM rats daily receiving oral dose of polysaccharide(100 ~ 400 mg/kg) with 50 ~ 210 kDa molecular weight (PF40) could not only significantly lower blood sugar but also reduce total triglyceride level in serum. PF40 improves in insulin tolerance inhibited the expression of some biomarkers including inflammatory cytokine TNF-α and elevated anti-inflammatory cytokine IL-10, regulated adiponectin Acrp30 and leptin. Conclusions PF40 prevent the cascade of inflammatory events in the treatment of T2DM to block overweight progresses to obesity. PMID:24131482

La Desnutrición, Malnutrición y el Rendimiento Académico de los Estudiantes del sexto grado de Educación Primaria de I.E.2028 Cerro Candela, SM.P. Lima, 2007

OpenAIRE

Zagastizabal Gamarra, Zaira Ruth

2015-01-01

Sabemos que la Fuente de la Vida de todo ser humano es la alimentación y el hombre sin alimento no puede sobrevivir por lo que; viendo los problemas de salud de los estudiantes desarrollé esta investigación titulada “La Desnutrición, mal nutrición y el rendimiento académico de los estudiantes del sexto grado de Educación Primaria de la I.E.2028 Cerro Candela, SMP. Lima, 2007”, siendo la muestra de 49 estudiantes. En el contenido de esta tesis se encuentra un conjunto de ante...

CGDM: collaborative genomic data model for molecular profiling data using NoSQL.

Science.gov (United States)

Wang, Shicai; Mares, Mihaela A; Guo, Yi-Ke

2016-12-01

High-throughput molecular profiling has greatly improved patient stratification and mechanistic understanding of diseases. With the increasing amount of data used in translational medicine studies in recent years, there is a need to improve the performance of data warehouses in terms of data retrieval and statistical processing. Both relational and Key Value models have been used for managing molecular profiling data. Key Value models such as SeqWare have been shown to be particularly advantageous in terms of query processing speed for large datasets. However, more improvement can be achieved, particularly through better indexing techniques of the Key Value models, taking advantage of the types of queries which are specific for the high-throughput molecular profiling data. In this article, we introduce a Collaborative Genomic Data Model (CGDM), aimed at significantly increasing the query processing speed for the main classes of queries on genomic databases. CGDM creates three Collaborative Global Clustering Index Tables (CGCITs) to solve the velocity and variety issues at the cost of limited extra volume. Several benchmarking experiments were carried out, comparing CGDM implemented on HBase to the traditional SQL data model (TDM) implemented on both HBase and MySQL Cluster, using large publicly available molecular profiling datasets taken from NCBI and HapMap. In the microarray case, CGDM on HBase performed up to 246 times faster than TDM on HBase and 7 times faster than TDM on MySQL Cluster. In single nucleotide polymorphism case, CGDM on HBase outperformed TDM on HBase by up to 351 times and TDM on MySQL Cluster by up to 9 times. The CGDM source code is available at https://github.com/evanswang/CGDM. y.guo@imperial.ac.uk. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Learning reduced kinetic Monte Carlo models of complex chemistry from molecular dynamics.

Science.gov (United States)

Yang, Qian; Sing-Long, Carlos A; Reed, Evan J

2017-08-01

We propose a novel statistical learning framework for automatically and efficiently building reduced kinetic Monte Carlo (KMC) models of large-scale elementary reaction networks from data generated by a single or few molecular dynamics simulations (MD). Existing approaches for identifying species and reactions from molecular dynamics typically use bond length and duration criteria, where bond duration is a fixed parameter motivated by an understanding of bond vibrational frequencies. In contrast, we show that for highly reactive systems, bond duration should be a model parameter that is chosen to maximize the predictive power of the resulting statistical model. We demonstrate our method on a high temperature, high pressure system of reacting liquid methane, and show that the learned KMC model is able to extrapolate more than an order of magnitude in time for key molecules. Additionally, our KMC model of elementary reactions enables us to isolate the most important set of reactions governing the behavior of key molecules found in the MD simulation. We develop a new data-driven algorithm to reduce the chemical reaction network which can be solved either as an integer program or efficiently using L1 regularization, and compare our results with simple count-based reduction. For our liquid methane system, we discover that rare reactions do not play a significant role in the system, and find that less than 7% of the approximately 2000 reactions observed from molecular dynamics are necessary to reproduce the molecular concentration over time of methane. The framework described in this work paves the way towards a genomic approach to studying complex chemical systems, where expensive MD simulation data can be reused to contribute to an increasingly large and accurate genome of elementary reactions and rates.

Performance Evaluation and Optimal Management of Distance-Based Registration Using a Semi-Markov Process

Directory of Open Access Journals (Sweden)

Jae Joon Suh

2017-01-01

Full Text Available We consider the distance-based registration (DBR which is a kind of dynamic location registration scheme in a mobile communication network. In the DBR, the location of a mobile station (MS is updated when it enters a base station more than or equal to a specified distance away from the base station where the location registration for the MS was done last. In this study, we first investigate the existing performance-evaluation methods on the DBR with implicit registration (DBIR presented to improve the performance of the DBR and point out some problems of the evaluation methods. We propose a new performance-evaluation method for the DBIR scheme using a semi-Markov process (SMP which can resolve the controversial issues of the existing methods. The numerical results obtained with the proposed SMP model are compared with those from previous models. It is shown that the SMP model should be considered to get an accurate performance of the DBIR scheme.

Molecular surface science of heterogeneous catalysis. History and perspective

International Nuclear Information System (INIS)

Somorjai, G.A.

1983-08-01

A personal account is given of how the author became involved with modern surface science and how it was employed for studies of the chemistry of surfaces and heterogeneous catalysis. New techniques were developed for studying the properties of the surface monolayers: Auger electron spectroscopy, LEED, XPS, molecular beam surface scattering, etc. An apparatus was developed and used to study hydrocarbon conversion reactions on Pt, CO hydrogenation on Rh and Fe, and NH 3 synthesis on Fe. A model has been developed for the working Pt reforming catalyst. The three molecular ingredients that control catalytic properties are atomic surface structure, an active carbonaceous deposit, and the proper oxidation state of surface atoms. 40 references, 21 figures

Molecular surface science of heterogeneous catalysis. History and perspective

Energy Technology Data Exchange (ETDEWEB)

Somorjai, G.A.

1983-08-01

A personal account is given of how the author became involved with modern surface science and how it was employed for studies of the chemistry of surfaces and heterogeneous catalysis. New techniques were developed for studying the properties of the surface monolayers: Auger electron spectroscopy, LEED, XPS, molecular beam surface scattering, etc. An apparatus was developed and used to study hydrocarbon conversion reactions on Pt, CO hydrogenation on Rh and Fe, and NH/sub 3/ synthesis on Fe. A model has been developed for the working Pt reforming catalyst. The three molecular ingredients that control catalytic properties are atomic surface structure, an active carbonaceous deposit, and the proper oxidation state of surface atoms. 40 references, 21 figures. (DLC)

Pressure effects on martensitic transformation under quenching process in a molecular dynamics model of NiAl alloy

International Nuclear Information System (INIS)

Kazanc, S.; Ozgen, S.; Adiguzel, O.

2003-01-01

The solid-solid phase transitions in NiAl alloys occur by the temperature changes and application of a pressure on the system. Both types of transitions are called martensitic transformation and have displacive and thermoelastic characters. Pressure effects on thermoelastic transformation in Ni 62.5 Al 37.5 alloy model have been studied by means of molecular dynamics method proposed by Parrinello-Rahman. Interaction forces between atoms in the model system were calculated by Lennard-Jones potential energy function. Thermodynamics and structural analysis of the martensitic transformations under hydrostatic pressure during the quenching processes have been performed. The simulation runs have been carried out in different hydrostatic pressures changing from zero to 40.65 GPa during the quenching process of the model alloy. At the zero and nonzero pressures, the system with B2-type ordered structure undergoes the product phase with L1 0 -type ordered structure by Bain distortion in the first step of martensitic transformation under the quenching process. The increase in hydrostatic pressure causes decrease in the formation time of the product phase, and twin-like lattice distortion is observed in low temperature L1 0 phase

Two Models of Magnetic Support for Photoevaporated Molecular Clouds

International Nuclear Information System (INIS)

Ryutov, D; Kane, J; Mizuta, A; Pound, M; Remington, B

2004-01-01

The thermal pressure inside molecular clouds is insufficient for maintaining the pressure balance at an ablation front at the cloud surface illuminated by nearby UV stars. Most probably, the required stiffness is provided by the magnetic pressure. After surveying existing models of this type, we concentrate on two of them: the model of a quasi-homogeneous magnetic field and the recently proposed model of a ''magnetostatic turbulence''. We discuss observational consequences of the two models, in particular, the structure and the strength of the magnetic field inside the cloud and in the ionized outflow. We comment on the possible role of reconnection events and their observational signatures. We mention laboratory experiments where the most significant features of the models can be tested

Molecular modeling of the microstructure evolution during carbon fiber processing

Science.gov (United States)

Desai, Saaketh; Li, Chunyu; Shen, Tongtong; Strachan, Alejandro

2017-12-01

The rational design of carbon fibers with desired properties requires quantitative relationships between the processing conditions, microstructure, and resulting properties. We developed a molecular model that combines kinetic Monte Carlo and molecular dynamics techniques to predict the microstructure evolution during the processes of carbonization and graphitization of polyacrylonitrile (PAN)-based carbon fibers. The model accurately predicts the cross-sectional microstructure of the fibers with the molecular structure of the stabilized PAN fibers and physics-based chemical reaction rates as the only inputs. The resulting structures exhibit key features observed in electron microcopy studies such as curved graphitic sheets and hairpin structures. In addition, computed X-ray diffraction patterns are in good agreement with experiments. We predict the transverse moduli of the resulting fibers between 1 GPa and 5 GPa, in good agreement with experimental results for high modulus fibers and slightly lower than those of high-strength fibers. The transverse modulus is governed by sliding between graphitic sheets, and the relatively low value for the predicted microstructures can be attributed to their perfect longitudinal texture. Finally, the simulations provide insight into the relationships between chemical kinetics and the final microstructure; we observe that high reaction rates result in porous structures with lower moduli.

Synchrotron-Based Microspectroscopic Analysis of Molecular and Biopolymer Structures Using Multivariate Techniques and Advanced Multi-Components Modeling

International Nuclear Information System (INIS)

Yu, P.

2008-01-01

More recently, advanced synchrotron radiation-based bioanalytical technique (SRFTIRM) has been applied as a novel non-invasive analysis tool to study molecular, functional group and biopolymer chemistry, nutrient make-up and structural conformation in biomaterials. This novel synchrotron technique, taking advantage of bright synchrotron light (which is million times brighter than sunlight), is capable of exploring the biomaterials at molecular and cellular levels. However, with the synchrotron RFTIRM technique, a large number of molecular spectral data are usually collected. The objective of this article was to illustrate how to use two multivariate statistical techniques: (1) agglomerative hierarchical cluster analysis (AHCA) and (2) principal component analysis (PCA) and two advanced multicomponent modeling methods: (1) Gaussian and (2) Lorentzian multi-component peak modeling for molecular spectrum analysis of bio-tissues. The studies indicated that the two multivariate analyses (AHCA, PCA) are able to create molecular spectral corrections by including not just one intensity or frequency point of a molecular spectrum, but by utilizing the entire spectral information. Gaussian and Lorentzian modeling techniques are able to quantify spectral omponent peaks of molecular structure, functional group and biopolymer. By application of these four statistical methods of the multivariate techniques and Gaussian and Lorentzian modeling, inherent molecular structures, functional group and biopolymer onformation between and among biological samples can be quantified, discriminated and classified with great efficiency.

Assessment of radiofrequency exposure from cellular telephone daily use in an epidemiological study: German Validation study of the international case-control study of cancers of the brain--INTERPHONE-Study.