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Sample records for single relay neuron

  1. Performance limitations of relay neurons.

    Directory of Open Access Journals (Sweden)

    Rahul Agarwal

    Full Text Available Relay cells are prevalent throughout sensory systems and receive two types of inputs: driving and modulating. The driving input contains receptive field properties that must be transmitted while the modulating input alters the specifics of transmission. For example, the visual thalamus contains relay neurons that receive driving inputs from the retina that encode a visual image, and modulating inputs from reticular activating system and layer 6 of visual cortex that control what aspects of the image will be relayed back to visual cortex for perception. What gets relayed depends on several factors such as attentional demands and a subject's goals. In this paper, we analyze a biophysical based model of a relay cell and use systems theoretic tools to construct analytic bounds on how well the cell transmits a driving input as a function of the neuron's electrophysiological properties, the modulating input, and the driving signal parameters. We assume that the modulating input belongs to a class of sinusoidal signals and that the driving input is an irregular train of pulses with inter-pulse intervals obeying an exponential distribution. Our analysis applies to any [Formula: see text] order model as long as the neuron does not spike without a driving input pulse and exhibits a refractory period. Our bounds on relay reliability contain performance obtained through simulation of a second and third order model, and suggest, for instance, that if the frequency of the modulating input increases or the DC offset decreases, then relay increases. Our analysis also shows, for the first time, how the biophysical properties of the neuron (e.g. ion channel dynamics define the oscillatory patterns needed in the modulating input for appropriately timed relay of sensory information. In our discussion, we describe how our bounds predict experimentally observed neural activity in the basal ganglia in (i health, (ii in Parkinson's disease (PD, and (iii in PD during

  2. Single neuron computation

    CERN Document Server

    McKenna, Thomas M; Zornetzer, Steven F

    1992-01-01

    This book contains twenty-two original contributions that provide a comprehensive overview of computational approaches to understanding a single neuron structure. The focus on cellular-level processes is twofold. From a computational neuroscience perspective, a thorough understanding of the information processing performed by single neurons leads to an understanding of circuit- and systems-level activity. From the standpoint of artificial neural networks (ANNs), a single real neuron is as complex an operational unit as an entire ANN, and formalizing the complex computations performed by real n

  3. A single-neuron tracing study of arkypallidal and prototypic neurons in healthy rats.

    Science.gov (United States)

    Fujiyama, Fumino; Nakano, Takashi; Matsuda, Wakoto; Furuta, Takahiro; Udagawa, Jun; Kaneko, Takeshi

    2016-12-01

    The external globus pallidus (GP) is known as a relay nucleus of the indirect pathway of the basal ganglia. Recent studies in dopamine-depleted and healthy rats indicate that the GP comprises two main types of pallidofugal neurons: the so-called "prototypic" and "arkypallidal" neurons. However, the reconstruction of complete arkypallidal neurons in healthy rats has not been reported. Here we visualized the entire axonal arborization of four single arkypallidal neurons and six single prototypic neurons in rat brain using labeling with a viral vector expressing membrane-targeted green fluorescent protein and examined the distribution of axon boutons in the target nuclei. Results revealed that not only the arkypallidal neurons but nearly all of the prototypic neurons projected to the striatum with numerous axon varicosities. Thus, the striatum is a major target nucleus for pallidal neurons. Arkypallidal and prototypic GP neurons located in the calbindin-positive and calbindin-negative regions mainly projected to the corresponding positive and negative regions in the striatum. Because the GP and striatum calbindin staining patterns reflect the topographic organization of the striatopallidal projection, the striatal neurons in the sensorimotor and associative regions constitute the reciprocal connection with the GP neurons in the corresponding regions.

  4. Model-based iterative learning control of Parkinsonian state in thalamic relay neuron

    Science.gov (United States)

    Liu, Chen; Wang, Jiang; Li, Huiyan; Xue, Zhiqin; Deng, Bin; Wei, Xile

    2014-09-01

    Although the beneficial effects of chronic deep brain stimulation on Parkinson's disease motor symptoms are now largely confirmed, the underlying mechanisms behind deep brain stimulation remain unclear and under debate. Hence, the selection of stimulation parameters is full of challenges. Additionally, due to the complexity of neural system, together with omnipresent noises, the accurate model of thalamic relay neuron is unknown. Thus, the iterative learning control of the thalamic relay neuron's Parkinsonian state based on various variables is presented. Combining the iterative learning control with typical proportional-integral control algorithm, a novel and efficient control strategy is proposed, which does not require any particular knowledge on the detailed physiological characteristics of cortico-basal ganglia-thalamocortical loop and can automatically adjust the stimulation parameters. Simulation results demonstrate the feasibility of the proposed control strategy to restore the fidelity of thalamic relay in the Parkinsonian condition. Furthermore, through changing the important parameter—the maximum ionic conductance densities of low-threshold calcium current, the dominant characteristic of the proposed method which is independent of the accurate model can be further verified.

  5. Improving throughput of single-relay DF channel using linear constellation precoding

    KAUST Repository

    Fareed, Muhammad Mehboob

    2014-08-01

    In this letter, we propose a transmission scheme to improve the overall throughput of a cooperative communication system with single decode-and-forward relay. Symbol error rate and throughput analysis of the new scheme are presented to facilitate the performance comparison with the existing decode-and-forward relaying schemes. Simulation results are further provided to corroborate the analytical results. © 2012 IEEE.

  6. Improving throughput of single-relay DF channel using linear constellation precoding

    KAUST Repository

    Fareed, Muhammad Mehboob; Yang, Hongchuan; Alouini, Mohamed-Slim

    2014-01-01

    In this letter, we propose a transmission scheme to improve the overall throughput of a cooperative communication system with single decode-and-forward relay. Symbol error rate and throughput analysis of the new scheme are presented to facilitate the performance comparison with the existing decode-and-forward relaying schemes. Simulation results are further provided to corroborate the analytical results. © 2012 IEEE.

  7. Resource allocation for two source-destination pairs sharing a single relay with a buffer

    KAUST Repository

    Zafar, Ammar; Shaqfeh, Mohammad; Alouini, Mohamed-Slim; Alnuweiri, Hussein M.

    2014-01-01

    In this paper, we obtain the optimal resource allocation scheme in order to maximize the achievable rate region in a dual-hop system that consists of two independent source-destination pairs sharing a single half-duplex relay. The relay decodes

  8. Strong, reliable and precise synaptic connections between thalamic relay cells and neurones of the nucleus reticularis in juvenile rats

    Science.gov (United States)

    Gentet, Luc J; Ulrich, Daniel

    2003-01-01

    The thalamic reticular nucleus (nRT) is composed entirely of GABAergic inhibitory neurones that receive input from pyramidal cortical neurones and excitatory relay cells of the ventrobasal complex of the thalamus (VB). It plays a major role in the synchrony of thalamic networks, yet the synaptic connections it receives from VB cells have never been fully physiologically characterised. Here, whole-cell current-clamp recordings were obtained from 22 synaptically connected VB-nRT cell pairs in slices of juvenile (P14–20) rats. At 34–36 °C, single presynaptic APs evoked unitary EPSPs in nRT cells with a peak amplitude of 7.4 ± 1.5 mV (mean ± s.e.m.) and a decay time constant of 15.1 ± 0.9 ms. Only four out of 22 pairs showed transmission failures at a mean rate of 6.8 ± 1.1 %. An NMDA receptor (NMDAR)-mediated component was significant at rest and subsequent EPSPs in a train were depressed. Only one out of 14 pairs tested was reciprocally connected; the observed IPSPs in the VB cell had a peak amplitude of 0.8 mV and were completely abolished in the presence of 10 μm bicuculline. Thus, synaptic connections from VB cells to nRT neurones are mainly ‘drivers’, while a small subset of cells form closed disynaptic loops. PMID:12563005

  9. Relay model for recruiting alcohol dependent patients in general hospitals--a single-blind pragmatic randomized trial

    DEFF Research Database (Denmark)

    Schwarz, Anne-Sophie; Bilberg, Randi; Bjerregaard, Lene Berit Skov

    2016-01-01

    - The Relay Model. METHOD/DESIGN: The study is a single-blind pragmatic randomized controlled trial including patients admitted to the hospital. The study group (n = 500) will receive an intervention, and the control group (n = 500) will be referred to treatment by usual procedures. All patients complete......://register.clinicaltrials.gov/by identifier: RESCueH_Relay NCT02188043 Project Relay Model for Recruiting Alcohol Dependent Patients in General Hospitals (TRN Registration: 07/09/2014)....

  10. Embryonic Cell Grafts in a Culture Model of Spinal Cord Lesion: Neuronal Relay Formation is Essential for Functional Regeneration

    Directory of Open Access Journals (Sweden)

    Anne Tscherter

    2016-09-01

    Full Text Available Presently there exists no cure for spinal cord injury. However, transplantation of embryonic tissue into spinal cord lesions resulted in axon outgrowth across the lesion site and some functional recovery, fostering hope for future stem cell therapies. Although in vivo evidence for functional recovery is given, the exact cellular mechanism of the graft support remains elusive: either the grafted cells provide a permissive environment for the host tissue to regenerate itself or the grafts actually integrate functionally into the host neuronal network reconnecting the separated spinal cord circuits. We tested the two hypotheses in an in vitro spinal cord lesion model that is based on propagation of activity between two rat organotypic spinal cord slices in culture. Transplantation of dissociated cells from E14 rat spinal cord or forebrain re-established the relay of activity over the lesion site and, thus, provoked functional regeneration. Combining patch-clamp recordings from transplanted cells with network activity measurements from the host tissue on multi-electrode arrays we here show that neurons differentiate from the grafted cells and integrate into the host circuits. Optogenetic silencing of neurons developed from transplanted embryonic mouse forebrain cells provides clear evidence that they replace the lost neuronal connections to relay and synchronize activity between the separated spinal cord circuits. In contrast, transplantation of neurospheres induced neither the differentiation of mature neurons from the grafts nor an improvement of functional regeneration. Together these findings suggest, that the formation of neuronal relays from grafted embryonic cells is essential to re-connect segregated spinal cord circuits.

  11. Protective relay

    International Nuclear Information System (INIS)

    Lim, Mu Ji; Jung, Hae Sang

    1974-10-01

    This book is divided into two chapters, which deals with protective relay. The first chapter deals with the basic knowledge of relay on development of relay, classification of protective relay, rating of protective relay general structure of protective relay, detecting of ground protection, about point of contact, operating relay and trip relaying. The second chapter is about structure and explanation of relay on classification by structure such as motor type and moving-coil type, explanation of other relays over current relay, over voltage relay, short voltage relay, relay for power, relay for direction, test of over voltage relay, test of short voltage relay and test of directional circuit relay.

  12. Electrochemical proton relay at the single-molecule level

    DEFF Research Database (Denmark)

    Kuznetsov, A. M.; Medvedev, I. G.; Ulstrup, Jens

    2009-01-01

    A scheme for the experimental study of single-proton transfer events, based on proton-coupled two-electron transfer between a proton donor and a proton acceptor molecule confined in the tunneling gap between two metal leads in electrolyte solution is suggested. Expressions for the electric current...... are derived and compared with formalism for electron tunneling through redox molecules. The scheme allows studying the kinetics of proton and hydrogen atom transfer as well as kinetic isotope effects at the single-molecule level under electrochemical potential control....

  13. Resource allocation for two source-destination pairs sharing a single relay with a buffer

    KAUST Repository

    Zafar, Ammar

    2014-05-01

    In this paper, we obtain the optimal resource allocation scheme in order to maximize the achievable rate region in a dual-hop system that consists of two independent source-destination pairs sharing a single half-duplex relay. The relay decodes the received information and possesses buffers to enable storing the information temporarily before forwarding it to the respective destination. We consider both non-orthogonal transmission with successive interference cancellation at the receivers and orthogonal transmission. Also, we consider Gaussian block-fading channels and we assume that the channel state information is known and that no delay constraints are required. We show that, with the aid of buffering at the relay, joint user-and-hop scheduling is optimal and can enhance the achievable rate significantly. This is due to the joint exploitation of multiuser diversity and multihop diversity in the system. We provide closed-form expressions to characterize the average achievable rates in a generic form as functions of the statistical model of the channels. Furthermore, we consider sub-optimal schemes that exploit the diversity in the system partially and we provide numerical results to compare the different schemes and demonstrate the gains of the optimal one. © 2014 IEEE.

  14. Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1.

    Science.gov (United States)

    Qian, Ying; Shirasawa, Senji; Chen, Chih-Li; Cheng, Leping; Ma, Qiufu

    2002-05-15

    Trigeminal nuclei and the dorsal spinal cord are first-order relay stations for processing somatic sensory information such as touch, pain, and temperature. The origins and development of these neurons are poorly understood. Here we show that relay somatic sensory neurons and D2/D4 dorsal interneurons likely derive from Mash1-positive neural precursors, and depend on two related homeobox genes, Rnx and Tlx-1, for proper formation. Rnx and Tlx-1 maintain expression of Drg11, a homeobox gene critical for the development of pain circuitry, and are essential for the ingrowth of trkA+ nociceptive/thermoceptive sensory afferents to their central targets. We showed previously that Rnx is necessary for proper formation of the nucleus of solitary tract, the target for visceral sensory afferents. Together, our studies demonstrate a central role for Rnx and Tlx-1 in the development of two major classes of relay sensory neurons, somatic and visceral.

  15. Current Source Density Estimation for Single Neurons

    Directory of Open Access Journals (Sweden)

    Dorottya Cserpán

    2014-03-01

    Full Text Available Recent developments of multielectrode technology made it possible to measure the extracellular potential generated in the neural tissue with spatial precision on the order of tens of micrometers and on submillisecond time scale. Combining such measurements with imaging of single neurons within the studied tissue opens up new experimental possibilities for estimating distribution of current sources along a dendritic tree. In this work we show that if we are able to relate part of the recording of extracellular potential to a specific cell of known morphology we can estimate the spatiotemporal distribution of transmembrane currents along it. We present here an extension of the kernel CSD method (Potworowski et al., 2012 applicable in such case. We test it on several model neurons of progressively complicated morphologies from ball-and-stick to realistic, up to analysis of simulated neuron activity embedded in a substantial working network (Traub et al, 2005. We discuss the caveats and possibilities of this new approach.

  16. A BMP-mediated transcriptional cascade involving Cash1 and Tlx-3 specifies first-order relay sensory neurons in the developing hindbrain.

    Science.gov (United States)

    Hornbruch, Amata; Ma, Grace; Ballermann, Mark A; Tumova, Katerina; Liu, Dan; Cairine Logan, C

    2005-07-01

    The divergent homeobox-containing transcription factor, Tlx-3 (also known as Hox11L2/Rnx), is required for proper formation of first-order relay sensory neurons in the developing vertebrate brainstem. To date, however, the inductive signals and transcriptional regulatory cascade underlying their development are poorly understood. We previously isolated the chick Tlx-3 homologue and showed it is expressed early (i.e. beginning at HH15) in distinct subcomponents of both the trigeminal/solitary and vestibular nuclei. Here we show via in vivo rhombomere inversions that expression of Tlx-3 is under control of local environmental signals. Our RNA in situ analysis shows expression of the BMP-specific receptor, Bmpr-1b, correlates well with Tlx-3. Furthermore, manipulation of the BMP signaling pathway in vivo via electroporation of expression vectors encoding either BMP or NOGGIN coupled with MASH1 gain-of-function experiments demonstrate that a BMP-mediated transcriptional cascade involving Cash1 and Tlx-3 specifies first-order relay sensory neurons in the developing brainstem. Notably, high-level Noggin misexpression results in an increase in newly differentiated Tlx-3+ neurons that correlates with a corresponding increase in the number of Calretinin+ neurons in vestibular nuclei at later developmental stages strongly suggesting that Tlx-3, in addition to being required for proper formation of somatic as well as visceral sensory neurons in the trigeminal and solitary nuclei, respectively, is sufficient for proper formation of special somatic sensory neurons in vestibular nuclei.

  17. Single-cell axotomy of cultured hippocampal neurons integrated in neuronal circuits.

    Science.gov (United States)

    Gomis-Rüth, Susana; Stiess, Michael; Wierenga, Corette J; Meyn, Liane; Bradke, Frank

    2014-05-01

    An understanding of the molecular mechanisms of axon regeneration after injury is key for the development of potential therapies. Single-cell axotomy of dissociated neurons enables the study of the intrinsic regenerative capacities of injured axons. This protocol describes how to perform single-cell axotomy on dissociated hippocampal neurons containing synapses. Furthermore, to axotomize hippocampal neurons integrated in neuronal circuits, we describe how to set up coculture with a few fluorescently labeled neurons. This approach allows axotomy of single cells in a complex neuronal network and the observation of morphological and molecular changes during axon regeneration. Thus, single-cell axotomy of mature neurons is a valuable tool for gaining insights into cell intrinsic axon regeneration and the plasticity of neuronal polarity of mature neurons. Dissociation of the hippocampus and plating of hippocampal neurons takes ∼2 h. Neurons are then left to grow for 2 weeks, during which time they integrate into neuronal circuits. Subsequent axotomy takes 10 min per neuron and further imaging takes 10 min per neuron.

  18. Discrimination of communication vocalizations by single neurons and groups of neurons in the auditory midbrain.

    Science.gov (United States)

    Schneider, David M; Woolley, Sarah M N

    2010-06-01

    Many social animals including songbirds use communication vocalizations for individual recognition. The perception of vocalizations depends on the encoding of complex sounds by neurons in the ascending auditory system, each of which is tuned to a particular subset of acoustic features. Here, we examined how well the responses of single auditory neurons could be used to discriminate among bird songs and we compared discriminability to spectrotemporal tuning. We then used biologically realistic models of pooled neural responses to test whether the responses of groups of neurons discriminated among songs better than the responses of single neurons and whether discrimination by groups of neurons was related to spectrotemporal tuning and trial-to-trial response variability. The responses of single auditory midbrain neurons could be used to discriminate among vocalizations with a wide range of abilities, ranging from chance to 100%. The ability to discriminate among songs using single neuron responses was not correlated with spectrotemporal tuning. Pooling the responses of pairs of neurons generally led to better discrimination than the average of the two inputs and the most discriminating input. Pooling the responses of three to five single neurons continued to improve neural discrimination. The increase in discriminability was largest for groups of neurons with similar spectrotemporal tuning. Further, we found that groups of neurons with correlated spike trains achieved the largest gains in discriminability. We simulated neurons with varying levels of temporal precision and measured the discriminability of responses from single simulated neurons and groups of simulated neurons. Simulated neurons with biologically observed levels of temporal precision benefited more from pooling correlated inputs than did neurons with highly precise or imprecise spike trains. These findings suggest that pooling correlated neural responses with the levels of precision observed in the

  19. From Parkinsonian thalamic activity to restoring thalamic relay using deep brain stimulation: new insights from computational modeling

    NARCIS (Netherlands)

    Meijer, Hil Gaétan Ellart; Krupa, M.; Cagnan, H.; Lourens, Marcel Antonius Johannes; Heida, Tjitske; Martens, H.C.F.; Bour, L.J.; van Gils, Stephanus A.

    2011-01-01

    We present a computational model of a thalamocortical relay neuron for exploring basal ganglia thalamocortical loop behavior in relation to Parkinson's disease and deep brain stimulation (DBS). Previous microelectrode, single-unit recording studies demonstrated that oscillatory interaction within

  20. Spiking neuron devices consisting of single-flux-quantum circuits

    International Nuclear Information System (INIS)

    Hirose, Tetsuya; Asai, Tetsuya; Amemiya, Yoshihito

    2006-01-01

    Single-flux-quantum (SFQ) circuits can be used for making spiking neuron devices, which are useful elements for constructing intelligent, brain-like computers. The device we propose is based on the leaky integrate-and-fire neuron (IFN) model and uses a SFQ pulse as an action signal or a spike of neurons. The operation of the neuron device is confirmed by computer simulator. It can operate with a short delay of 100 ps or less and is the highest-speed neuron device ever reported

  1. Relay Selection and Resource Allocation in One-Way and Two-Way Cognitive Relay Networks

    KAUST Repository

    Alsharoa, Ahmad M.

    2013-01-01

    In this work, the problem of relay selection and resource power allocation in one- way and two-way cognitive relay networks using half duplex channels with different relaying protocols is investigated. Optimization problems for both single

  2. Capacity Bounds on the Downlink of Symmetric, Multi-Relay, Single-Receiver C-RAN Networks

    Directory of Open Access Journals (Sweden)

    Shirin Saeedi Bidokhti

    2017-11-01

    Full Text Available The downlink of symmetric Cloud Radio Access Networks (C-RANs with multiple relays and a single receiver is studied. Lower and upper bounds are derived on the capacity. The lower bound is achieved by Marton’s coding, which facilitates dependence among the multiple-access channel inputs. The upper bound uses Ozarow’s technique to augment the system with an auxiliary random variable. The bounds are studied over scalar Gaussian C-RANs and are shown to meet and characterize the capacity for interesting regimes of operation.

  3. Single neuron dynamics during experimentally induced anoxic depolarization

    NARCIS (Netherlands)

    Zandt, B.; Stigen, Tyler; ten Haken, Bernard; Netoff, Theoden; van Putten, Michel Johannes Antonius Maria

    2013-01-01

    We studied single neuron dynamics during anoxic depolarizations, which are often observed in cases of neuronal energy depletion. Anoxic and similar depolarizations play an important role in several pathologies, notably stroke, migraine, and epilepsy. One of the effects of energy depletion was

  4. Relay race

    CERN Multimedia

    Staff Association

    2011-01-01

    The CERN relay race will take place around the Meyrin site on Thursday 19th May starting at 12:15. If possible, please avoid driving on the site during this 20-minute period. If you do meet runners while driving your car, please STOP until they have all passed. Thank you for your cooperation. Details on the course, and how to register your team for the relay race, can be found at: https://espace.cern.ch/Running-Club/CERN-Relay Some advice for all runners from the medical service can also be found here: https://espace.cern.ch/Running-Club/CERN-Relay/RelayPagePictures/MedicalServiceAnnoncement.pdf

  5. Relay race

    CERN Document Server

    Staff Association

    2011-01-01

    The CERN relay race will take place around the Meyrin site on Thursday 19th May starting at 12·15. If possible, please avoid driving on the site during this 20-minute period. If you do meet runners while driving your car, please STOP until they have all passed. Thank you for your cooperation. Details on the course, and how to register your team for the relay race, can be found at: https://espace.cern.ch/Running-Club/CERN-Relay Some advice for all runners from the medical service can also be found here: https://espace.cern.ch/Running-Club/CERN-Relay/RelayPagePictures/MedicalServiceAnnoncement.pdf

  6. Frequency-selectivity of a thalamocortical relay neuron during Parkinson's disease and deep brain stimulation: a computational study

    NARCIS (Netherlands)

    Cagnan, Hayriye; Cagnan, H.; Meijer, Hil Gaétan Ellart; van Gils, Stephanus A.; Krupa, M.; Heida, Tjitske; Rudolph, Michelle; Wadman, Wyse J.; Martens, Hubert C.F.

    2009-01-01

    In this computational study, we investigated (i) the functional importance of correlated basal ganglia (BG) activity associated with Parkinson's disease (PD) motor symptoms by analysing the effects of globus pallidus internum (GPi) bursting frequency and synchrony on a thalamocortical (TC) relay

  7. An analysis of the operation of a single-pole relay integrated circuit device with a controlled reset ratio

    Energy Technology Data Exchange (ETDEWEB)

    Reshetov, N.E.

    1980-01-01

    Relay equipment using semiconductor components (such as those containing gates using planar transformers, and a relay in networks which control the operational time of a relay) are widely used in the automation equipment of electric power systems. A scheme where a gate in the form of an integrated circuit is used is given.

  8. Understanding metal homeostasis in primary cultured neurons. Studies using single neuron subcellular and quantitative metallomics.

    Science.gov (United States)

    Colvin, Robert A; Lai, Barry; Holmes, William R; Lee, Daewoo

    2015-07-01

    The purpose of this study was to demonstrate how single cell quantitative and subcellular metallomics inform us about both the spatial distribution and cellular mechanisms of metal buffering and homeostasis in primary cultured neurons from embryonic rat brain, which are often used as models of human disease involving metal dyshomeostasis. The present studies utilized synchrotron radiation X-ray fluorescence (SRXRF) and focused primarily on zinc and iron, two abundant metals in neurons that have been implicated in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Total single cell contents for calcium, iron, zinc, copper, manganese, and nickel were determined. Resting steady state zinc showed a diffuse distribution in both soma and processes, best defined by the mass profile of the neuron with an enrichment in the nucleus compared with the cytoplasm. Zinc buffering and homeostasis was studied using two modes of cellular zinc loading - transporter and ionophore (pyrithione) mediated. Single neuron zinc contents were shown to statistically significantly increase by either loading method - ionophore: 160 million to 7 billion; transporter 160 million to 280 million atoms per neuronal soma. The newly acquired and buffered zinc still showed a diffuse distribution. Soma and processes have about equal abilities to take up zinc via transporter mediated pathways. Copper levels are distributed diffusely as well, but are relatively higher in the processes relative to zinc levels. Prior studies have observed iron puncta in certain cell types, but others have not. In the present study, iron puncta were characterized in several primary neuronal types. The results show that iron puncta could be found in all neuronal types studied and can account for up to 50% of the total steady state content of iron in neuronal soma. Although other metals can be present in iron puncta, they are predominantly iron containing and do not appear to be

  9. Discrimination of Communication Vocalizations by Single Neurons and Groups of Neurons in the Auditory Midbrain

    OpenAIRE

    Schneider, David M.; Woolley, Sarah M. N.

    2010-01-01

    Many social animals including songbirds use communication vocalizations for individual recognition. The perception of vocalizations depends on the encoding of complex sounds by neurons in the ascending auditory system, each of which is tuned to a particular subset of acoustic features. Here, we examined how well the responses of single auditory neurons could be used to discriminate among bird songs and we compared discriminability to spectrotemporal tuning. We then used biologically realistic...

  10. Stochastic models for spike trains of single neurons

    CERN Document Server

    Sampath, G

    1977-01-01

    1 Some basic neurophysiology 4 The neuron 1. 1 4 1. 1. 1 The axon 7 1. 1. 2 The synapse 9 12 1. 1. 3 The soma 1. 1. 4 The dendrites 13 13 1. 2 Types of neurons 2 Signals in the nervous system 14 2. 1 Action potentials as point events - point processes in the nervous system 15 18 2. 2 Spontaneous activi~ in neurons 3 Stochastic modelling of single neuron spike trains 19 3. 1 Characteristics of a neuron spike train 19 3. 2 The mathematical neuron 23 4 Superposition models 26 4. 1 superposition of renewal processes 26 4. 2 Superposition of stationary point processe- limiting behaviour 34 4. 2. 1 Palm functions 35 4. 2. 2 Asymptotic behaviour of n stationary point processes superposed 36 4. 3 Superposition models of neuron spike trains 37 4. 3. 1 Model 4. 1 39 4. 3. 2 Model 4. 2 - A superposition model with 40 two input channels 40 4. 3. 3 Model 4. 3 4. 4 Discussion 41 43 5 Deletion models 5. 1 Deletion models with 1nd~endent interaction of excitatory and inhibitory sequences 44 VI 5. 1. 1 Model 5. 1 The basic de...

  11. Responses of single neurons and neuronal ensembles in frog first- and second-order olfactory neurons

    Czech Academy of Sciences Publication Activity Database

    Rospars, J. P.; Šanda, Pavel; Lánský, Petr; Duchamp-Viret, P.

    2013-01-01

    Roč. 1536, NOV 6 (2013), s. 144-158 ISSN 0006-8993 R&D Projects: GA ČR(CZ) GBP304/12/G069; GA ČR(CZ) GAP103/11/0282 Institutional support: RVO:67985823 Keywords : olfaction * spiking activity * neuronal model Subject RIV: JD - Computer Applications, Robotics Impact factor: 2.828, year: 2013

  12. Coding of vocalizations by single neurons in ventrolateral prefrontal cortex.

    Science.gov (United States)

    Plakke, Bethany; Diltz, Mark D; Romanski, Lizabeth M

    2013-11-01

    Neuronal activity in single prefrontal neurons has been correlated with behavioral responses, rules, task variables and stimulus features. In the non-human primate, neurons recorded in ventrolateral prefrontal cortex (VLPFC) have been found to respond to species-specific vocalizations. Previous studies have found multisensory neurons which respond to simultaneously presented faces and vocalizations in this region. Behavioral data suggests that face and vocal information are inextricably linked in animals and humans and therefore may also be tightly linked in the coding of communication calls in prefrontal neurons. In this study we therefore examined the role of VLPFC in encoding vocalization call type information. Specifically, we examined previously recorded single unit responses from the VLPFC in awake, behaving rhesus macaques in response to 3 types of species-specific vocalizations made by 3 individual callers. Analysis of responses by vocalization call type and caller identity showed that ∼19% of cells had a main effect of call type with fewer cells encoding caller. Classification performance of VLPFC neurons was ∼42% averaged across the population. When assessed at discrete time bins, classification performance reached 70 percent for coos in the first 300 ms and remained above chance for the duration of the response period, though performance was lower for other call types. In light of the sub-optimal classification performance of the majority of VLPFC neurons when only vocal information is present, and the recent evidence that most VLPFC neurons are multisensory, the potential enhancement of classification with the addition of accompanying face information is discussed and additional studies recommended. Behavioral and neuronal evidence has shown a considerable benefit in recognition and memory performance when faces and voices are presented simultaneously. In the natural environment both facial and vocalization information is present simultaneously and

  13. SWIPT in Multiuser MIMO Decode-and-Forward Relay Broadcasting Channel with Energy Harvesting Relays

    KAUST Repository

    Benkhelifa, Fatma; Salem, Ahmed Sultan; Alouini, Mohamed-Slim

    2017-01-01

    In this paper, we consider a multiuser multiple- input multiple-output (MIMO) decode-and-forward (DF) relay broadcasting channel (BC) with single source, multiple energy harvesting relays and multiple destinations. Since the end-to-end sum rate

  14. Stimulus-response functions of single avian olfactory bulb neurones.

    Science.gov (United States)

    McKeegan, Dorothy E F; Demmers, Theodorus G M; Wathes, Christopher M; Jones, R Bryan; Gentle, Michael J

    2002-10-25

    This study investigated olfactory processing in a functional context by examining the responses of single avian olfactory bulb neurones to two biologically important gases over relevant concentration ranges. Recordings of extracellular spike activity were made from 80 single units in the left olfactory bulb of 11 anaesthetised, freely breathing adult hens (Gallus domesticus). The units were spontaneously active, exhibiting widely variable firing rates (0.07-47.28 spikes/s) and variable temporal firing patterns. Single units were tested for their response to an ascending concentration series of either ammonia (2.5-100 ppm) or hydrogen sulphide (1-50 ppm), delivered directly to the olfactory epithelium. Stimulation with a calibrated gas delivery system resulted in modification of spontaneous activity causing either inhibition (47% of units) or excitation (53%) of firing. For ammonia, 20 of the 35 units tested exhibited a response, while for hydrogen sulphide, 25 of the 45 units tested were responsive. Approximate response thresholds for ammonia (median threshold 3.75 ppm (range 2.5-60 ppm, n=20)) and hydrogen sulphide (median threshold 1 ppm (range 1-10 ppm, n=25)) were determined with most units exhibiting thresholds near the lower end of these ranges. Stimulus response curves were constructed for 23 units; 16 (the most complete) were subjected to a linear regression analysis to determine whether they were best fitted by a linear, log or power function. No single function provided the best fit for all the curves (seven were linear, eight were log, one was power). These findings show that avian units respond to changes in stimulus concentration in a manner generally consistent with reported responses in mammalian olfactory bulb neurones. However, this study illustrates a level of fine-tuning to small step changes in concentration (<5 ppm) not previously demonstrated in vertebrate single olfactory bulb neurones.

  15. Single neurons in prefrontal cortex encode abstract rules.

    Science.gov (United States)

    Wallis, J D; Anderson, K C; Miller, E K

    2001-06-21

    The ability to abstract principles or rules from direct experience allows behaviour to extend beyond specific circumstances to general situations. For example, we learn the 'rules' for restaurant dining from specific experiences and can then apply them in new restaurants. The use of such rules is thought to depend on the prefrontal cortex (PFC) because its damage often results in difficulty in following rules. Here we explore its neural basis by recording from single neurons in the PFC of monkeys trained to use two abstract rules. They were required to indicate whether two successively presented pictures were the same or different depending on which rule was currently in effect. The monkeys performed this task with new pictures, thus showing that they had learned two general principles that could be applied to stimuli that they had not yet experienced. The most prevalent neuronal activity observed in the PFC reflected the coding of these abstract rules.

  16. Human temporal cortical single neuron activity during working memory maintenance.

    Science.gov (United States)

    Zamora, Leona; Corina, David; Ojemann, George

    2016-06-01

    The Working Memory model of human memory, first introduced by Baddeley and Hitch (1974), has been one of the most influential psychological constructs in cognitive psychology and human neuroscience. However the neuronal correlates of core components of this model have yet to be fully elucidated. Here we present data from two studies where human temporal cortical single neuron activity was recorded during tasks differentially affecting the maintenance component of verbal working memory. In Study One we vary the presence or absence of distracting items for the entire period of memory storage. In Study Two we vary the duration of storage so that distractors filled all, or only one-third of the time the memory was stored. Extracellular single neuron recordings were obtained from 36 subjects undergoing awake temporal lobe resections for epilepsy, 25 in Study one, 11 in Study two. Recordings were obtained from a total of 166 lateral temporal cortex neurons during performance of one of these two tasks, 86 study one, 80 study two. Significant changes in activity with distractor manipulation were present in 74 of these neurons (45%), 38 Study one, 36 Study two. In 48 (65%) of those there was increased activity during the period when distracting items were absent, 26 Study One, 22 Study Two. The magnitude of this increase was greater for Study One, 47.6%, than Study Two, 8.1%, paralleling the reduction in memory errors in the absence of distracters, for Study One of 70.3%, Study Two 26.3% These findings establish that human lateral temporal cortex is part of the neural system for working memory, with activity during maintenance of that memory that parallels performance, suggesting it represents active rehearsal. In 31 of these neurons (65%) this activity was an extension of that during working memory encoding that differed significantly from the neural processes recorded during overt and silent language tasks without a recent memory component, 17 Study one, 14 Study two

  17. Human Temporal Cortical Single Neuron Activity During Working Memory Maintenance

    Science.gov (United States)

    Zamora, Leona; Corina, David; Ojemann, George

    2016-01-01

    The Working Memory model of human memory, first introduced by Baddeley and Hitch (1974), has been one of the most influential psychological constructs in cognitive psychology and human neuroscience. However the neuronal correlates of core components of this model have yet to be fully elucidated. Here we present data from two studies where human temporal cortical single neuron activity was recorded during tasks differentially affecting the maintenance component of verbal working memory. In Study One we vary the presence or absence of distracting items for the entire period of memory storage. In Study Two we vary the duration of storage so that distractors filled all, or only one-third of the time the memory was stored. Extracellular single neuron recordings were obtained from 36 subjects undergoing awake temporal lobe resections for epilepsy, 25 in Study one, 11 in Study two. Recordings were obtained from a total of 166 lateral temporal cortex neurons during performance of one of these two tasks, 86 study one, 80 study two. Significant changes in activity with distractor manipulation were present in 74 of these neurons (45%), 38 Study one, 36 Study two. In 48 (65%) of those there was increased activity during the period when distracting items were absent, 26 Study One, 22 Study Two. The magnitude of this increase was greater for Study One, 47.6%, than Study Two, 8.1%, paralleling the reduction in memory errors in the absence of distracters, for Study One of 70.3%, Study Two 26.3% These findings establish that human lateral temporal cortex is part of the neural system for working memory, with activity during maintenance of that memory that parallels performance, suggesting it represents active rehearsal. In 31 of these neurons (65%) this activity was an extension of that during working memory encoding that differed significantly from the neural processes recorded during overt and silent language tasks without a recent memory component, 17 Study one, 14 Study two

  18. hamlet, a binary genetic switch between single- and multiple- dendrite neuron morphology.

    Science.gov (United States)

    Moore, Adrian W; Jan, Lily Yeh; Jan, Yuh Nung

    2002-08-23

    The dendritic morphology of neurons determines the number and type of inputs they receive. In the Drosophila peripheral nervous system (PNS), the external sensory (ES) neurons have a single nonbranched dendrite, whereas the lineally related multidendritic (MD) neurons have extensively branched dendritic arbors. We report that hamlet is a binary genetic switch between these contrasting morphological types. In hamlet mutants, ES neurons are converted to an MD fate, whereas ectopic hamlet expression in MD precursors results in transformation of MD neurons into ES neurons. Moreover, hamlet expression induced in MD neurons undergoing dendrite outgrowth drastically reduces arbor branching.

  19. Existence of multiple receptors in single neurons: responses of single bullfrog olfactory neurons to many cAMP-dependent and independent odorants.

    Science.gov (United States)

    Kashiwayanagi, M; Shimano, K; Kurihara, K

    1996-11-04

    The responses of single bullfrog olfactory neurons to various odorants were measured with the whole-cell patch clamp which offers direct information on cellular events and with the ciliary recording technique to obtain stable quantitative data from many neurons. A large portion of single olfactory neurons (about 64% and 79% in the whole-cell recording and in the ciliary recording, respectively) responded to many odorants with quite diverse molecular structures, including both odorants previously indicated to be cAMP-dependent (increasing) and independent odorants. One odorant elicited a response in many cells; e.g. hedione and citralva elicited the response in 100% and 92% of total neurons examined with the ciliary recording technique. To confirm that a single neuron carries different receptors or transduction pathways, the cross-adaptation technique was applied to single neurons. Application of hedione to a single neuron after desensitization of the current in response to lyral or citralva induced an inward current with a similar magnitude to that applied alone. It was suggested that most single olfactory neurons carry multiple receptors and at least dual transduction pathways.

  20. Telecommunications Relay Services

    Science.gov (United States)

    ... Home » Health Info » Hearing, Ear Infections, and Deafness Telecommunications Relay Services On this page: What are telecommunication ... additional information about telecommunication relay services? What are telecommunication relay services? Title IV of the Americans with ...

  1. Spiking irregularity and frequency modulate the behavioral report of single-neuron stimulation.

    Science.gov (United States)

    Doron, Guy; von Heimendahl, Moritz; Schlattmann, Peter; Houweling, Arthur R; Brecht, Michael

    2014-02-05

    The action potential activity of single cortical neurons can evoke measurable sensory effects, but it is not known how spiking parameters and neuronal subtypes affect the evoked sensations. Here, we examined the effects of spike train irregularity, spike frequency, and spike number on the detectability of single-neuron stimulation in rat somatosensory cortex. For regular-spiking, putative excitatory neurons, detectability increased with spike train irregularity and decreasing spike frequencies but was not affected by spike number. Stimulation of single, fast-spiking, putative inhibitory neurons led to a larger sensory effect compared to regular-spiking neurons, and the effect size depended only on spike irregularity. An ideal-observer analysis suggests that, under our experimental conditions, rats were using integration windows of a few hundred milliseconds or more. Our data imply that the behaving animal is sensitive to single neurons' spikes and even to their temporal patterning. Copyright © 2014 Elsevier Inc. All rights reserved.

  2. Relay Selection and Resource Allocation in One-Way and Two-Way Cognitive Relay Networks

    KAUST Repository

    Alsharoa, Ahmad M.

    2013-05-08

    In this work, the problem of relay selection and resource power allocation in one- way and two-way cognitive relay networks using half duplex channels with different relaying protocols is investigated. Optimization problems for both single and multiple relay selection that maximize the sum rate of the secondary network without degrading the quality of service of the primary network by respecting a tolerated interference threshold were formulated. Single relay selection and optimal power allocation for two-way relaying cognitive radio networks using decode-and-forward and amplify-and-forward protocols were studied. Dual decomposition and subgradient methods were used to find the optimal power allocation. The transmission process to exchange two different messages between two transceivers for two-way relaying technique takes place in two time slots. In the first slot, the transceivers transmit their signals simultaneously to the relay. Then, during the second slot the relay broadcasts its signal to the terminals. Moreover, improvement of both spectral and energy efficiency can be achieved compared with the one-way relaying technique. As an extension, a multiple relay selection for both one-way and two-way relaying under cognitive radio scenario using amplify-and-forward were discussed. A strong optimization tool based on genetic and iterative algorithms was employed to solve the 
formulated optimization problems for both single and multiple relay selection, where discrete relay power levels were considered. Simulation results show that the practical and low-complexity heuristic approaches achieve almost the same performance of the optimal relay selection schemes either with discrete or continuous power distributions while providing a considerable saving in terms of computational complexity.

  3. Mapping cortical mesoscopic networks of single spiking cortical or sub-cortical neurons.

    Science.gov (United States)

    Xiao, Dongsheng; Vanni, Matthieu P; Mitelut, Catalin C; Chan, Allen W; LeDue, Jeffrey M; Xie, Yicheng; Chen, Andrew Cn; Swindale, Nicholas V; Murphy, Timothy H

    2017-02-04

    Understanding the basis of brain function requires knowledge of cortical operations over wide-spatial scales, but also within the context of single neurons. In vivo, wide-field GCaMP imaging and sub-cortical/cortical cellular electrophysiology were used in mice to investigate relationships between spontaneous single neuron spiking and mesoscopic cortical activity. We make use of a rich set of cortical activity motifs that are present in spontaneous activity in anesthetized and awake animals. A mesoscale spike-triggered averaging procedure allowed the identification of motifs that are preferentially linked to individual spiking neurons by employing genetically targeted indicators of neuronal activity. Thalamic neurons predicted and reported specific cycles of wide-scale cortical inhibition/excitation. In contrast, spike-triggered maps derived from single cortical neurons yielded spatio-temporal maps expected for regional cortical consensus function. This approach can define network relationships between any point source of neuronal spiking and mesoscale cortical maps.

  4. Opportunistic Relay Selection With Limited Feedback

    KAUST Repository

    Eltayeb, Mohammed E.

    2015-08-01

    Relay selection is a simple technique that achieves spatial diversity in cooperative relay networks. Generally, relay selection algorithms require channel state information (CSI) feedback from all cooperating relays to make a selection decision. This requirement poses two important challenges, which are often neglected in the literature. Firstly, the fed back channel information is usually corrupted by additive noise. Secondly, CSI feedback generates a great deal of feedback overhead (air-time) that could result in significant performance hits. In this paper, we propose a compressive sensing (CS) based relay selection algorithm that reduces the feedback overhead of relay networks under the assumption of noisy feedback channels. The proposed algorithm exploits CS to first obtain the identity of a set of relays with favorable channel conditions. Following that, the CSI of the identified relays is estimated using least squares estimation without any additional feedback. Both single and multiple relay selection cases are considered. After deriving closed-form expressions for the asymptotic end-to-end SNR at the destination and the feedback load for different relaying protocols, we show that CS-based selection drastically reduces the feedback load and achieves a rate close to that obtained by selection algorithms with dedicated error-free feedback. © 1972-2012 IEEE.

  5. Reward-timing-dependent bidirectional modulation of cortical microcircuits during optical single-neuron operant conditioning.

    Science.gov (United States)

    Hira, Riichiro; Ohkubo, Fuki; Masamizu, Yoshito; Ohkura, Masamichi; Nakai, Junichi; Okada, Takashi; Matsuzaki, Masanori

    2014-11-24

    Animals rapidly adapt to environmental change. To reveal how cortical microcircuits are rapidly reorganized when an animal recognizes novel reward contingency, we conduct two-photon calcium imaging of layer 2/3 motor cortex neurons in mice and simultaneously reinforce the activity of a single cortical neuron with water delivery. Here we show that when the target neuron is not relevant to a pre-trained forelimb movement, the mouse increases the target neuron activity and the number of rewards delivered during 15-min operant conditioning without changing forelimb movement behaviour. The reinforcement bidirectionally modulates the activity of subsets of non-target neurons, independent of distance from the target neuron. The bidirectional modulation depends on the relative timing between the reward delivery and the neuronal activity, and is recreated by pairing reward delivery and photoactivation of a subset of neurons. Reward-timing-dependent bidirectional modulation may be one of the fundamental processes in microcircuit reorganization for rapid adaptation.

  6. Relay race

    CERN Multimedia

    Staff Association

    2012-01-01

    The CERN Relay Race will take place around the Meyrin site on Thursday 24th May at 12:00. This annual event is for teams of six runners covering distances of 1000 m, 800 m, 800 m, 500 m, 500 m and 300 m respectively. Teams may be entered in the Seniors, Veterans, Ladies, Mixed or Open categories. There will also this year be a Nordic Walking event, as part of the Medical Service’s initiative “Move more, eat better!” The registration fee is 10 CHF per runner, and each runner will receive a souvenir prize. There will be a programme of entertainment from 12:00 on the arrival area (the lawn in front of Restaurant 1): 12:00 - 12:45  Music from the Old Bottom Street band 12:15 Start of the race 12:45 - 13h Demonstrations by the Fitness club and Dancing club 13:00 Results and prize giving (including a raffle to win an iPad2 3G offered by the Micro club) 13:20 à 14:00 Music from “What’s next” And many information st...

  7. Imaging Action Potential in Single Mammalian Neurons by Tracking the Accompanying Sub-Nanometer Mechanical Motion.

    Science.gov (United States)

    Yang, Yunze; Liu, Xian-Wei; Wang, Hui; Yu, Hui; Guan, Yan; Wang, Shaopeng; Tao, Nongjian

    2018-03-28

    Action potentials in neurons have been studied traditionally by intracellular electrophysiological recordings and more recently by the fluorescence detection methods. Here we describe a label-free optical imaging method that can measure mechanical motion in single cells with a sub-nanometer detection limit. Using the method, we have observed sub-nanometer mechanical motion accompanying the action potential in single mammalian neurons by averaging the repeated action potential spikes. The shape and width of the transient displacement are similar to those of the electrically recorded action potential, but the amplitude varies from neuron to neuron, and from one region of a neuron to another, ranging from 0.2-0.4 nm. The work indicates that action potentials may be studied noninvasively in single mammalian neurons by label-free imaging of the accompanying sub-nanometer mechanical motion.

  8. Experimental evaluation of earthquake induced relay chattering

    International Nuclear Information System (INIS)

    Bandyopadhyay, K.; Hofmayer, C.; Shteyngart, S.

    1990-01-01

    An experimental evaluation of relay performance under vibratory environments is discussed in this paper. Single frequency excitation was used for most tests. Limited tests were performed with random multifrequency inputs. The capacity of each relay was established based on a two-millisecond chatter criterion. The experimental techniques are described and the effects of parameters in controlling the relay capacity levels are illustrated with test data. A wide variation of the capacity levels was observed due to the influence of parameters related to the design of the relay and nature of the input motion. 3 refs., 15 figs

  9. Single-Cell Gene Expression Analysis of Cholinergic Neurons in the Arcuate Nucleus of the Hypothalamus.

    Directory of Open Access Journals (Sweden)

    Jae Hoon Jeong

    Full Text Available The cholinoceptive system in the hypothalamus, in particular in the arcuate nucleus (ARC, plays a role in regulating food intake. Neurons in the ARC contain multiple neuropeptides, amines, and neurotransmitters. To study molecular and neurochemical heterogeneity of ARC neurons, we combine single-cell qRT-PCR and single-cell whole transcriptome amplification methods to analyze expression patterns of our hand-picked 60 genes in individual neurons in the ARC. Immunohistochemical and single-cell qRT-PCR analyses show choline acetyltransferase (ChAT-expressing neurons in the ARC. Gene expression patterns are remarkably distinct in each individual cholinergic neuron. Two-thirds of cholinergic neurons express tyrosine hydroxylase (Th mRNA. A large subset of these Th-positive cholinergic neurons is GABAergic as they express the GABA synthesizing enzyme glutamate decarboxylase and vesicular GABA transporter transcripts. Some cholinergic neurons also express the vesicular glutamate transporter transcript gene. POMC and POMC-processing enzyme transcripts are found in a subpopulation of cholinergic neurons. Despite this heterogeneity, gene expression patterns in individual cholinergic cells appear to be highly regulated in a cell-specific manner. In fact, membrane receptor transcripts are clustered with their respective intracellular signaling and downstream targets. This novel population of cholinergic neurons may be part of the neural circuitries that detect homeostatic need for food and control the drive to eat.

  10. A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity

    DEFF Research Database (Denmark)

    Brandt, Julia P; Aziz-Zaman, Sonya; Juozaityte, Vaida

    2012-01-01

    . We report here a mechanism that endows C. elegans neurons with the ability to detect CO(2). The ETS-5 transcription factor is necessary for the specification of CO(2)-sensing BAG neurons. Expression of a single ETS-5 target gene, gcy-9, which encodes a receptor-type guanylate cyclase, is sufficient...

  11. Laser capture microdissection of enriched populations of neurons or single neurons for gene expression analysis after traumatic brain injury.

    Science.gov (United States)

    Boone, Deborah R; Sell, Stacy L; Hellmich, Helen Lee

    2013-04-10

    Long-term cognitive disability after TBI is associated with injury-induced neurodegeneration in the hippocampus-a region in the medial temporal lobe that is critical for learning, memory and executive function. Hence our studies focus on gene expression analysis of specific neuronal populations in distinct subregions of the hippocampus. The technique of laser capture microdissection (LCM), introduced in 1996 by Emmert-Buck, et al., has allowed for significant advances in gene expression analysis of single cells and enriched populations of cells from heterogeneous tissues such as the mammalian brain that contains thousands of functional cell types. We use LCM and a well established rat model of traumatic brain injury (TBI) to investigate the molecular mechanisms that underlie the pathogenesis of TBI. Following fluid-percussion TBI, brains are removed at pre-determined times post-injury, immediately frozen on dry ice, and prepared for sectioning in a cryostat. The rat brains can be embedded in OCT and sectioned immediately, or stored several months at -80 °C before sectioning for laser capture microdissection. Additionally, we use LCM to study the effects of TBI on circadian rhythms. For this, we capture neurons from the suprachiasmatic nuclei that contain the master clock of the mammalian brain. Here, we demonstrate the use of LCM to obtain single identified neurons (injured and degenerating, Fluoro-Jade-positive, or uninjured, Fluoro-Jade-negative) and enriched populations of hippocampal neurons for subsequent gene expression analysis by real time PCR and/or whole-genome microarrays. These LCM-enabled studies have revealed that the selective vulnerability of anatomically distinct regions of the rat hippocampus are reflected in the different gene expression profiles of different populations of neurons obtained by LCM from these distinct regions. The results from our single-cell studies, where we compare the transcriptional profiles of dying and adjacent surviving

  12. Efficient incremental relaying

    KAUST Repository

    Fareed, Muhammad Mehboob; Alouini, Mohamed-Slim

    2013-01-01

    We propose a novel relaying scheme which improves the spectral efficiency of cooperative diversity systems by utilizing limited feedback from destination. Our scheme capitalizes on the fact that relaying is only required when direct transmission

  13. Attending to and remembering tactile stimuli: a review of brain imaging data and single-neuron responses.

    Science.gov (United States)

    Burton, H; Sinclair, R J

    2000-11-01

    Clinical and neuroimaging observations of the cortical network implicated in tactile attention have identified foci in parietal somatosensory, posterior parietal, and superior frontal locations. Tasks involving intentional hand-arm movements activate similar or nearby parietal and frontal foci. Visual spatial attention tasks and deliberate visuomotor behavior also activate overlapping posterior parietal and frontal foci. Studies in the visual and somatosensory systems thus support a proposal that attention to the spatial location of an object engages cortical regions responsible for the same coordinate referents used for guiding purposeful motor behavior. Tactile attention also biases processing in the somatosensory cortex through amplification of responses to relevant features of selected stimuli. Psychophysical studies demonstrate retention gradients for tactile stimuli like those reported for visual and auditory stimuli, and suggest analogous neural mechanisms for working memory across modalities. Neuroimaging studies in humans using memory tasks, and anatomic studies in monkeys support the idea that tactile information relayed from the somatosensory cortex is directed ventrally through the insula to the frontal cortex for short-term retention and to structures of the medial temporal lobe for long-term encoding. At the level of single neurons, tactile (such as visual and auditory) short-term memory appears as a persistent response during delay intervals between sampled stimuli.

  14. Efficient incremental relaying

    KAUST Repository

    Fareed, Muhammad Mehboob

    2013-07-01

    We propose a novel relaying scheme which improves the spectral efficiency of cooperative diversity systems by utilizing limited feedback from destination. Our scheme capitalizes on the fact that relaying is only required when direct transmission suffers deep fading. We calculate the packet error rate for the proposed efficient incremental relaying scheme with both amplify and forward and decode and forward relaying. Numerical results are also presented to verify their analytical counterparts. © 2013 IEEE.

  15. Optimized Power Allocation and Relay Location Selection in Cooperative Relay Networks

    Directory of Open Access Journals (Sweden)

    Jianrong Bao

    2017-01-01

    Full Text Available An incremental selection hybrid decode-amplify forward (ISHDAF scheme for the two-hop single relay systems and a relay selection strategy based on the hybrid decode-amplify-and-forward (HDAF scheme for the multirelay systems are proposed along with an optimized power allocation for the Internet of Thing (IoT. Given total power as the constraint and outage probability as an objective function, the proposed scheme possesses good power efficiency better than the equal power allocation. By the ISHDAF scheme and HDAF relay selection strategy, an optimized power allocation for both the source and relay nodes is obtained, as well as an effective reduction of outage probability. In addition, the optimal relay location for maximizing the gain of the proposed algorithm is also investigated and designed. Simulation results show that, in both single relay and multirelay selection systems, some outage probability gains by the proposed scheme can be obtained. In the comparison of the optimized power allocation scheme with the equal power allocation one, nearly 0.1695 gains are obtained in the ISHDAF single relay network at a total power of 2 dB, and about 0.083 gains are obtained in the HDAF relay selection system with 2 relays at a total power of 2 dB.

  16. 80537 based distance relay

    DEFF Research Database (Denmark)

    Pedersen, Knud Ole Helgesen

    1999-01-01

    A method for implementing a digital distance relay in the power system is described.Instructions are given on how to program this relay on a 80537 based microcomputer system.The problem is used as a practical case study in the course 53113: Micocomputer applications in the power system.The relay...

  17. Internally generated preactivation of single neurons in human medial frontal cortex predicts volition

    Science.gov (United States)

    Fried, Itzhak; Mukamel, Roy; Kreiman, Gabriel

    2011-01-01

    Understanding how self-initiated behavior is encoded by neuronal circuits in the human brain remains elusive. We recorded the activity of 1019 neurons while twelve subjects performed self-initiated finger movement. We report progressive neuronal recruitment over ~1500 ms before subjects report making the decision to move. We observed progressive increase or decrease in neuronal firing rate, particularly in the supplementary motor area (SMA), as the reported time of decision was approached. A population of 256 SMA neurons is sufficient to predict in single trials the impending decision to move with accuracy greater than 80% already 700 ms prior to subjects’ awareness. Furthermore, we predict, with a precision of a few hundred ms, the actual time point of this voluntary decision to move. We implement a computational model whereby volition emerges once a change in internally generated firing rate of neuronal assemblies crosses a threshold. PMID:21315264

  18. High-Throughput Mapping of Single-Neuron Projections by Sequencing of Barcoded RNA.

    Science.gov (United States)

    Kebschull, Justus M; Garcia da Silva, Pedro; Reid, Ashlan P; Peikon, Ian D; Albeanu, Dinu F; Zador, Anthony M

    2016-09-07

    Neurons transmit information to distant brain regions via long-range axonal projections. In the mouse, area-to-area connections have only been systematically mapped using bulk labeling techniques, which obscure the diverse projections of intermingled single neurons. Here we describe MAPseq (Multiplexed Analysis of Projections by Sequencing), a technique that can map the projections of thousands or even millions of single neurons by labeling large sets of neurons with random RNA sequences ("barcodes"). Axons are filled with barcode mRNA, each putative projection area is dissected, and the barcode mRNA is extracted and sequenced. Applying MAPseq to the locus coeruleus (LC), we find that individual LC neurons have preferred cortical targets. By recasting neuroanatomy, which is traditionally viewed as a problem of microscopy, as a problem of sequencing, MAPseq harnesses advances in sequencing technology to permit high-throughput interrogation of brain circuits. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Gender differences in human single neuron responses to male emotional faces.

    Science.gov (United States)

    Newhoff, Morgan; Treiman, David M; Smith, Kris A; Steinmetz, Peter N

    2015-01-01

    Well-documented differences in the psychology and behavior of men and women have spurred extensive exploration of gender's role within the brain, particularly regarding emotional processing. While neuroanatomical studies clearly show differences between the sexes, the functional effects of these differences are less understood. Neuroimaging studies have shown inconsistent locations and magnitudes of gender differences in brain hemodynamic responses to emotion. To better understand the neurophysiology of these gender differences, we analyzed recordings of single neuron activity in the human brain as subjects of both genders viewed emotional expressions. This study included recordings of single-neuron activity of 14 (6 male) epileptic patients in four brain areas: amygdala (236 neurons), hippocampus (n = 270), anterior cingulate cortex (n = 256), and ventromedial prefrontal cortex (n = 174). Neural activity was recorded while participants viewed a series of avatar male faces portraying positive, negative or neutral expressions. Significant gender differences were found in the left amygdala, where 23% (n = 15∕66) of neurons in men were significantly affected by facial emotion, vs. 8% (n = 6∕76) of neurons in women. A Fisher's exact test comparing the two ratios found a highly significant difference between the two (p differences between genders at the single-neuron level in the human amygdala. These differences may reflect gender-based distinctions in evolved capacities for emotional processing and also demonstrate the importance of including subject gender as an independent factor in future studies of emotional processing by single neurons in the human amygdala.

  20. Auditory-nerve single-neuron thresholds to electrical stimulation from scala tympani electrodes.

    Science.gov (United States)

    Parkins, C W; Colombo, J

    1987-12-31

    Single auditory-nerve neuron thresholds were studied in sensory-deafened squirrel monkeys to determine the effects of electrical stimulus shape and frequency on single-neuron thresholds. Frequency was separated into its components, pulse width and pulse rate, which were analyzed separately. Square and sinusoidal pulse shapes were compared. There were no or questionably significant threshold differences in charge per phase between sinusoidal and square pulses of the same pulse width. There was a small (less than 0.5 dB) but significant threshold advantage for 200 microseconds/phase pulses delivered at low pulse rates (156 pps) compared to higher pulse rates (625 pps and 2500 pps). Pulse width was demonstrated to be the prime determinant of single-neuron threshold, resulting in strength-duration curves similar to other mammalian myelinated neurons, but with longer chronaxies. The most efficient electrical stimulus pulse width to use for cochlear implant stimulation was determined to be 100 microseconds/phase. This pulse width delivers the lowest charge/phase at threshold. The single-neuron strength-duration curves were compared to strength-duration curves of a computer model based on the specific anatomy of auditory-nerve neurons. The membrane capacitance and resulting chronaxie of the model can be varied by altering the length of the unmyelinated termination of the neuron, representing the unmyelinated portion of the neuron between the habenula perforata and the hair cell. This unmyelinated segment of the auditory-nerve neuron may be subject to aminoglycoside damage. Simulating a 10 micron unmyelinated termination for this model neuron produces a strength-duration curve that closely fits the single-neuron data obtained from aminoglycoside deafened animals. Both the model and the single-neuron strength-duration curves differ significantly from behavioral threshold data obtained from monkeys and humans with cochlear implants. This discrepancy can best be explained by

  1. Relays undergo seismic tests

    International Nuclear Information System (INIS)

    Burton, J.C.

    1977-01-01

    Utilities are required by the Nuclear Regulatory Commission to document that seismic vibration will not adversely affect critical electrical equipment. Seismic testing should be designed to determine the malfunction level (fragility testing). Input possibilities include a continuous sine, a decaying sine, a sine beat, random vibrations, and combinations of random vibrations and sine beat. The sine beat most accurately simulates a seismic event. Test frequencies have a broad range in order to accommodate a variety of relay types and cabinet mounting. Simulation of motion along three axes offers several options, but is best achieved by three in-phase single-axis vibration machines that are less likely to induce testing fatigue failure. Consensus on what constitutes relay failure favors a maximum two microsecond discontinuity. Performance tests should be conducted for at least two of the following: (1) nonoperating modes, (2) operating modes, or (3) the transition above the two modes, with the monitoring mode documented for all three. Results should specify a capability curve of maximum safe seismic acceleration and a graph plotting acceleration with sine-beat frequency

  2. Stable long-term chronic brain mapping at the single-neuron level.

    Science.gov (United States)

    Fu, Tian-Ming; Hong, Guosong; Zhou, Tao; Schuhmann, Thomas G; Viveros, Robert D; Lieber, Charles M

    2016-10-01

    Stable in vivo mapping and modulation of the same neurons and brain circuits over extended periods is critical to both neuroscience and medicine. Current electrical implants offer single-neuron spatiotemporal resolution but are limited by such factors as relative shear motion and chronic immune responses during long-term recording. To overcome these limitations, we developed a chronic in vivo recording and stimulation platform based on flexible mesh electronics, and we demonstrated stable multiplexed local field potentials and single-unit recordings in mouse brains for at least 8 months without probe repositioning. Properties of acquired signals suggest robust tracking of the same neurons over this period. This recording and stimulation platform allowed us to evoke stable single-neuron responses to chronic electrical stimulation and to carry out longitudinal studies of brain aging in freely behaving mice. Such advantages could open up future studies in mapping and modulating changes associated with learning, aging and neurodegenerative diseases.

  3. Stochastic optimal control of single neuron spike trains

    DEFF Research Database (Denmark)

    Iolov, Alexandre; Ditlevsen, Susanne; Longtin, Andrë

    2014-01-01

    stimulation of a neuron to achieve a target spike train under the physiological constraint to not damage tissue. Approach. We pose a stochastic optimal control problem to precisely specify the spike times in a leaky integrate-and-fire (LIF) model of a neuron with noise assumed to be of intrinsic or synaptic...... origin. In particular, we allow for the noise to be of arbitrary intensity. The optimal control problem is solved using dynamic programming when the controller has access to the voltage (closed-loop control), and using a maximum principle for the transition density when the controller only has access...... to the spike times (open-loop control). Main results. We have developed a stochastic optimal control algorithm to obtain precise spike times. It is applicable in both the supra-threshold and sub-threshold regimes, under open-loop and closed-loop conditions and with an arbitrary noise intensity; the accuracy...

  4. Kaleido: Visualizing Big Brain Data with Automatic Color Assignment for Single-Neuron Images.

    Science.gov (United States)

    Wang, Ting-Yuan; Chen, Nan-Yow; He, Guan-Wei; Wang, Guo-Tzau; Shih, Chi-Tin; Chiang, Ann-Shyn

    2018-03-03

    Effective 3D visualization is essential for connectomics analysis, where the number of neural images easily reaches over tens of thousands. A formidable challenge is to simultaneously visualize a large number of distinguishable single-neuron images, with reasonable processing time and memory for file management and 3D rendering. In the present study, we proposed an algorithm named "Kaleido" that can visualize up to at least ten thousand single neurons from the Drosophila brain using only a fraction of the memory traditionally required, without increasing computing time. Adding more brain neurons increases memory only nominally. Importantly, Kaleido maximizes color contrast between neighboring neurons so that individual neurons can be easily distinguished. Colors can also be assigned to neurons based on biological relevance, such as gene expression, neurotransmitters, and/or development history. For cross-lab examination, the identity of every neuron is retrievable from the displayed image. To demonstrate the effectiveness and tractability of the method, we applied Kaleido to visualize the 10,000 Drosophila brain neurons obtained from the FlyCircuit database ( http://www.flycircuit.tw/modules.php?name=kaleido ). Thus, Kaleido visualization requires only sensible computer memory for manual examination of big connectomics data.

  5. Racing to learn: statistical inference and learning in a single spiking neuron with adaptive kernels.

    Science.gov (United States)

    Afshar, Saeed; George, Libin; Tapson, Jonathan; van Schaik, André; Hamilton, Tara J

    2014-01-01

    This paper describes the Synapto-dendritic Kernel Adapting Neuron (SKAN), a simple spiking neuron model that performs statistical inference and unsupervised learning of spatiotemporal spike patterns. SKAN is the first proposed neuron model to investigate the effects of dynamic synapto-dendritic kernels and demonstrate their computational power even at the single neuron scale. The rule-set defining the neuron is simple: there are no complex mathematical operations such as normalization, exponentiation or even multiplication. The functionalities of SKAN emerge from the real-time interaction of simple additive and binary processes. Like a biological neuron, SKAN is robust to signal and parameter noise, and can utilize both in its operations. At the network scale neurons are locked in a race with each other with the fastest neuron to spike effectively "hiding" its learnt pattern from its neighbors. The robustness to noise, high speed, and simple building blocks not only make SKAN an interesting neuron model in computational neuroscience, but also make it ideal for implementation in digital and analog neuromorphic systems which is demonstrated through an implementation in a Field Programmable Gate Array (FPGA). Matlab, Python, and Verilog implementations of SKAN are available at: http://www.uws.edu.au/bioelectronics_neuroscience/bens/reproducible_research.

  6. Spatially Controlled Relay Beamforming

    Science.gov (United States)

    Kalogerias, Dionysios

    layered channel model previously described, this line of research has resulted in a number of general, asymptotic convergence results, advancing the theory of grid-based approximate nonlinear stochastic filtering. In particular, sufficient conditions, ensuring asymptotic optimality are relaxed, and, at the same time, the mode of convergence is strengthened. Although the need for such results initiated as an attempt to theoretically characterize the performance of the proposed approximate methods for statistical inference, in regard to the proposed channel modeling approach, they turn out to be of fundamental importance in the areas of nonlinear estimation and stochastic control. The experimental validation of the proposed channel model, as well as the related parameter estimation problem, termed as "Markovian Channel Profiling (MCP)", fundamentally important for any practical deployment, are subject of current, ongoing research. Second, adopting the first of the two aforementioned channel modeling approaches, we consider the spatially controlled relay beamforming problem for an AF network with a single source, a single destination, and multiple, controlled at will, relay nodes. (Abstract shortened by ProQuest.).

  7. Reconstruction of neuronal input through modeling single-neuron dynamics and computations

    International Nuclear Information System (INIS)

    Qin, Qing; Wang, Jiang; Yu, Haitao; Deng, Bin; Chan, Wai-lok

    2016-01-01

    Mathematical models provide a mathematical description of neuron activity, which can better understand and quantify neural computations and corresponding biophysical mechanisms evoked by stimulus. In this paper, based on the output spike train evoked by the acupuncture mechanical stimulus, we present two different levels of models to describe the input-output system to achieve the reconstruction of neuronal input. The reconstruction process is divided into two steps: First, considering the neuronal spiking event as a Gamma stochastic process. The scale parameter and the shape parameter of Gamma process are, respectively, defined as two spiking characteristics, which are estimated by a state-space method. Then, leaky integrate-and-fire (LIF) model is used to mimic the response system and the estimated spiking characteristics are transformed into two temporal input parameters of LIF model, through two conversion formulas. We test this reconstruction method by three different groups of simulation data. All three groups of estimates reconstruct input parameters with fairly high accuracy. We then use this reconstruction method to estimate the non-measurable acupuncture input parameters. Results show that under three different frequencies of acupuncture stimulus conditions, estimated input parameters have an obvious difference. The higher the frequency of the acupuncture stimulus is, the higher the accuracy of reconstruction is.

  8. Reconstruction of neuronal input through modeling single-neuron dynamics and computations

    Energy Technology Data Exchange (ETDEWEB)

    Qin, Qing; Wang, Jiang; Yu, Haitao; Deng, Bin, E-mail: dengbin@tju.edu.cn; Chan, Wai-lok [School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072 (China)

    2016-06-15

    Mathematical models provide a mathematical description of neuron activity, which can better understand and quantify neural computations and corresponding biophysical mechanisms evoked by stimulus. In this paper, based on the output spike train evoked by the acupuncture mechanical stimulus, we present two different levels of models to describe the input-output system to achieve the reconstruction of neuronal input. The reconstruction process is divided into two steps: First, considering the neuronal spiking event as a Gamma stochastic process. The scale parameter and the shape parameter of Gamma process are, respectively, defined as two spiking characteristics, which are estimated by a state-space method. Then, leaky integrate-and-fire (LIF) model is used to mimic the response system and the estimated spiking characteristics are transformed into two temporal input parameters of LIF model, through two conversion formulas. We test this reconstruction method by three different groups of simulation data. All three groups of estimates reconstruct input parameters with fairly high accuracy. We then use this reconstruction method to estimate the non-measurable acupuncture input parameters. Results show that under three different frequencies of acupuncture stimulus conditions, estimated input parameters have an obvious difference. The higher the frequency of the acupuncture stimulus is, the higher the accuracy of reconstruction is.

  9. Single-neuron identification of chemical constituents, physiological changes, and metabolism using mass spectrometry.

    Science.gov (United States)

    Zhu, Hongying; Zou, Guichang; Wang, Ning; Zhuang, Meihui; Xiong, Wei; Huang, Guangming

    2017-03-07

    The use of single-cell assays has emerged as a cutting-edge technique during the past decade. Although single-cell mass spectrometry (MS) has recently achieved remarkable results, deep biological insights have not yet been obtained, probably because of various technical issues, including the unavoidable use of matrices, the inability to maintain cell viability, low throughput because of sample pretreatment, and the lack of recordings of cell physiological activities from the same cell. In this study, we describe a patch clamp/MS-based platform that enables the sensitive, rapid, and in situ chemical profiling of single living neurons. This approach integrates modified patch clamp technique and modified MS measurements to directly collect and detect nanoliter-scale samples from the cytoplasm of single neurons in mice brain slices. Abundant possible cytoplasmic constituents were detected in a single neuron at a relatively fast rate, and over 50 metabolites were identified in this study. The advantages of direct, rapid, and in situ sampling and analysis enabled us to measure the biological activities of the cytoplasmic constituents in a single neuron, including comparing neuron types by cytoplasmic chemical constituents; observing changes in constituent concentrations as the physiological conditions, such as age, vary; and identifying the metabolic pathways of small molecules.

  10. Induction of associative olfactory memory by targeted activation of single olfactory neurons in Drosophila larvae.

    Science.gov (United States)

    Honda, Takato; Lee, Chi-Yu; Yoshida-Kasikawa, Maki; Honjo, Ken; Furukubo-Tokunaga, Katsuo

    2014-04-25

    It has been postulated that associative memory is formed by at least two sets of external stimuli, CS and US, that are transmitted to the memory centers by distinctive conversing pathways. However, whether associative memory can be induced by the activation of only the olfactory CS and a biogenic amine-mediated US pathways remains to be elucidated. In this study, we substituted the reward signals with dTrpA1-mediated thermogenetic activation of octopaminergic neurons and the odor signals by ChR2-mediated optical activation of a specific class of olfactory neurons. We show that targeted activation of the olfactory receptor and the octopaminergic neurons is indeed sufficient for the formation of associative olfactory memory in the larval brain. We also show that targeted stimulation of only a single type of olfactory receptor neurons is sufficient to induce olfactory memory that is indistinguishable from natural memory induced by the activation of multiple olfactory receptor neurons.

  11. Single Ih channels in pyramidal neuron dendrites: properties, distribution, and impact on action potential output

    NARCIS (Netherlands)

    Kole, Maarten H. P.; Hallermann, Stefan; Stuart, Greg J.

    2006-01-01

    The hyperpolarization-activated cation current (Ih) plays an important role in regulating neuronal excitability, yet its native single-channel properties in the brain are essentially unknown. Here we use variance-mean analysis to study the properties of single Ih channels in the apical dendrites of

  12. Creation of defined single cell resolution neuronal circuits on microelectrode arrays

    Science.gov (United States)

    Pirlo, Russell Kirk

    2009-12-01

    The way cell-cell organization of neuronal networks influences activity and facilitates function is not well understood. Microelectrode arrays (MEAs) and advancing cell patterning technologies have enabled access to and control of in vitro neuronal networks spawning much new research in neuroscience and neuroengineering. We propose that small, simple networks of neurons with defined circuitry may serve as valuable research models where every connection can be analyzed, controlled and manipulated. Towards the goal of creating such neuronal networks we have applied microfabricated elastomeric membranes, surface modification and our unique laser cell patterning system to create defined neuronal circuits with single-cell precision on MEAs. Definition of synaptic connectivity was imposed by the 3D physical constraints of polydimethylsiloxane elastomeric membranes. The membranes had 20mum clear-through holes and 2-3mum deep channels which when applied to the surface of the MEA formed microwells to confine neurons to electrodes connected via shallow tunnels to direct neurite outgrowth. Tapering and turning of channels was used to influence neurite polarity. Biocompatibility of the membranes was increased by vacuum baking, oligomer extraction, and autoclaving. Membranes were bound to the MEA by oxygen plasma treatment and heated pressure. The MEA/membrane surface was treated with oxygen plasma, poly-D-lysine and laminin to improve neuron attachment, survival and neurite outgrowth. Prior to cell patterning the outer edge of culture area was seeded with 5x10 5 cells per cm and incubated for 2 days. Single embryonic day 7 chick forebrain neurons were then patterned into the microwells and onto the electrodes using our laser cell patterning system. Patterned neurons successfully attached to and were confined to the electrodes. Neurites extended through the interconnecting channels and connected with adjacent neurons. These results demonstrate that neuronal circuits can be

  13. Simultaneous transcranial magnetic stimulation and single neuron recording in alert non-human primates

    OpenAIRE

    Mueller, Jerel K.; Grigsby, Erinn M.; Prevosto, Vincent; Petraglia, Frank W.; Rao, Hrishikesh; Deng, Zhi-De; Peterchev, Angel V.; Sommer, Marc A.; Egner, Tobias; Platt, Michael L.; Grill, Warren M.

    2014-01-01

    Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating nervous tissue, yet its mechanisms of effect are poorly understood. Here we report novel methods for studying the influence of TMS on single neurons in the brain of alert non-human primates. We designed a TMS coil that focuses its effect near the tip of a recording electrode and recording electronics that enable direct acquisition of neuronal signals at the site of peak stimulus strength minimally per...

  14. Pulsed neural networks consisting of single-flux-quantum spiking neurons

    International Nuclear Information System (INIS)

    Hirose, T.; Asai, T.; Amemiya, Y.

    2007-01-01

    An inhibitory pulsed neural network was developed for brain-like information processing, by using single-flux-quantum (SFQ) circuits. It consists of spiking neuron devices that are coupled to each other through all-to-all inhibitory connections. The network selects neural activity. The operation of the neural network was confirmed by computer simulation. SFQ neuron devices can imitate the operation of the inhibition phenomenon of neural networks

  15. Robust distributed cognitive relay beamforming

    KAUST Repository

    Pandarakkottilil, Ubaidulla

    2012-05-01

    In this paper, we present a distributed relay beamformer design for a cognitive radio network in which a cognitive (or secondary) transmit node communicates with a secondary receive node assisted by a set of cognitive non-regenerative relays. The secondary nodes share the spectrum with a licensed primary user (PU) node, and each node is assumed to be equipped with a single transmit/receive antenna. The interference to the PU resulting from the transmission from the cognitive nodes is kept below a specified limit. The proposed robust cognitive relay beamformer design seeks to minimize the total relay transmit power while ensuring that the transceiver signal-to-interference- plus-noise ratio and PU interference constraints are satisfied. The proposed design takes into account a parameter of the error in the channel state information (CSI) to render the performance of the beamformer robust in the presence of imperfect CSI. Though the original problem is non-convex, we show that the proposed design can be reformulated as a tractable convex optimization problem that can be solved efficiently. Numerical results are provided and illustrate the performance of the proposed designs for different network operating conditions and parameters. © 2012 IEEE.

  16. Functional adaptation to loading of a single bone is neuronally regulated and involves multiple bones.

    Science.gov (United States)

    Sample, Susannah J; Behan, Mary; Smith, Lesley; Oldenhoff, William E; Markel, Mark D; Kalscheur, Vicki L; Hao, Zhengling; Miletic, Vjekoslav; Muir, Peter

    2008-09-01

    Regulation of load-induced bone formation is considered a local phenomenon controlled by osteocytes, although it has also been hypothesized that functional adaptation may be neuronally regulated. The aim of this study was to examine bone formation in multiple bones, in response to loading of a single bone, and to determine whether adaptation may be neuronally regulated. Load-induced responses in the left and right ulnas and humeri were determined after loading of the right ulna in male Sprague-Dawley rats (69 +/- 16 days of age). After a single period of loading at -760-, -2000-, or -3750-microepsilon initial peak strain, rats were given calcein to label new bone formation. Bone formation and bone neuropeptide concentrations were determined at 10 days. In one group, temporary neuronal blocking was achieved by perineural anesthesia of the brachial plexus with bupivicaine during loading. We found right ulna loading induces adaptive responses in other bones in both thoracic limbs compared with Sham controls and that neuronal blocking during loading abrogated bone formation in the loaded ulna and other thoracic limb bones. Skeletal adaptation was more evident in distal long bones compared with proximal long bones. We also found that the single period of loading modulated bone neuropeptide concentrations persistently for 10 days. We conclude that functional adaptation to loading of a single bone in young rapidly growing rats is neuronally regulated and involves multiple bones. Persistent changes in bone neuropeptide concentrations after a single loading period suggest that plasticity exists in the innervation of bone.

  17. CERN Relay Race

    CERN Document Server

    CERN Running Club

    2010-01-01

    The CERN relay race will take place around the Meyrin site on Thursday 20 May, starting at 12.15. If possible, please avoid driving on the site during this 20-minute period. If you do meet runners while driving your car, please STOP until they have all passed. Thank you for your cooperation. Details on the route, and how to register your team for the relay race, can be found at: https://espace.cern.ch/Running-Club/CERN-Relay

  18. Single or multiple synchronization transitions in scale-free neuronal networks with electrical or chemical coupling

    International Nuclear Information System (INIS)

    Hao Yinghang; Gong, Yubing; Wang Li; Ma Xiaoguang; Yang Chuanlu

    2011-01-01

    Research highlights: → Single synchronization transition for gap-junctional coupling. → Multiple synchronization transitions for chemical synaptic coupling. → Gap junctions and chemical synapses have different impacts on synchronization transition. → Chemical synapses may play a dominant role in neurons' information processing. - Abstract: In this paper, we have studied time delay- and coupling strength-induced synchronization transitions in scale-free modified Hodgkin-Huxley (MHH) neuron networks with gap-junctions and chemical synaptic coupling. It is shown that the synchronization transitions are much different for these two coupling types. For gap-junctions, the neurons exhibit a single synchronization transition with time delay and coupling strength, while for chemical synapses, there are multiple synchronization transitions with time delay, and the synchronization transition with coupling strength is dependent on the time delay lengths. For short delays we observe a single synchronization transition, whereas for long delays the neurons exhibit multiple synchronization transitions as the coupling strength is varied. These results show that gap junctions and chemical synapses have different impacts on the pattern formation and synchronization transitions of the scale-free MHH neuronal networks, and chemical synapses, compared to gap junctions, may play a dominant and more active function in the firing activity of the networks. These findings would be helpful for further understanding the roles of gap junctions and chemical synapses in the firing dynamics of neuronal networks.

  19. Single or multiple synchronization transitions in scale-free neuronal networks with electrical or chemical coupling

    Energy Technology Data Exchange (ETDEWEB)

    Hao Yinghang [School of Physics, Ludong University, Yantai 264025 (China); Gong, Yubing, E-mail: gongyubing09@hotmail.co [School of Physics, Ludong University, Yantai 264025 (China); Wang Li; Ma Xiaoguang; Yang Chuanlu [School of Physics, Ludong University, Yantai 264025 (China)

    2011-04-15

    Research highlights: Single synchronization transition for gap-junctional coupling. Multiple synchronization transitions for chemical synaptic coupling. Gap junctions and chemical synapses have different impacts on synchronization transition. Chemical synapses may play a dominant role in neurons' information processing. - Abstract: In this paper, we have studied time delay- and coupling strength-induced synchronization transitions in scale-free modified Hodgkin-Huxley (MHH) neuron networks with gap-junctions and chemical synaptic coupling. It is shown that the synchronization transitions are much different for these two coupling types. For gap-junctions, the neurons exhibit a single synchronization transition with time delay and coupling strength, while for chemical synapses, there are multiple synchronization transitions with time delay, and the synchronization transition with coupling strength is dependent on the time delay lengths. For short delays we observe a single synchronization transition, whereas for long delays the neurons exhibit multiple synchronization transitions as the coupling strength is varied. These results show that gap junctions and chemical synapses have different impacts on the pattern formation and synchronization transitions of the scale-free MHH neuronal networks, and chemical synapses, compared to gap junctions, may play a dominant and more active function in the firing activity of the networks. These findings would be helpful for further understanding the roles of gap junctions and chemical synapses in the firing dynamics of neuronal networks.

  20. Radioisotope relay instrument

    International Nuclear Information System (INIS)

    Pozdnyakov, V.N.; Sazonov, O.L.; Taksar, I.M.; Tesnavs, Eh.R.; Yanushkovskij, V.A.

    1974-01-01

    The paper describes a radioisotope relay device containing a radiation source, a detector, an electronic relay block with a comparative threshold mechanism. The device differs from previously known ones in that, for the purpose of increasing stability and speed of action, the electronic relay block is a separate unit and contains two threshold pulse generators which are joined up, across series-connected ''and'' and ''or'' elements, with one of the inputs of the comparative threshold mechanism, whose second input is connected with a detector and whose outputs are connected with a relay element connected by feedback with the above-mentioned ''and'' elements. (author)

  1. Neuronal synchrony detection on single-electron neural networks

    International Nuclear Information System (INIS)

    Oya, Takahide; Asai, Tetsuya; Kagaya, Ryo; Hirose, Tetsuya; Amemiya, Yoshihito

    2006-01-01

    Synchrony detection between burst and non-burst spikes is known to be one functional example of depressing synapses. Kanazawa et al. demonstrated synchrony detection with MOS depressing synapse circuits. They found that the performance of a network with depressing synapses that discriminates between burst and random input spikes increases non-monotonically as the static device mismatch is increased. We designed a single-electron depressing synapse and constructed the same network as in Kanazawa's study to develop noise-tolerant single-electron circuits. We examined the temperature characteristics and explored possible architecture that enables single-electron circuits to operate at T > 0 K

  2. Neurons the decision makers, Part I: The firing function of a single neuron.

    Science.gov (United States)

    Saaty, Thomas

    2017-02-01

    This paper is concerned with understanding synthesis of electric signals in the neural system based on making pairwise comparisons. Fundamentally, every person and every animal are born with the talent to compare stimuli from things that share properties in space or over time. Comparisons always need experience to distinguish among things. Pairwise comparisons are numerically reciprocal. If a value is assigned to the larger of two elements that have a given property when compared with the smaller one, then the smaller has the reciprocal of that value when compared with the larger. Because making comparisons requires the reciprocal property, we need mathematics that can cope with division. There are four division algebras that would allow us to use our reciprocals arising from comparisons: The real numbers, the complex numbers, the non-commutative quaternions and the non-associative octonions. Rather than inferring function as from electric flow in a network, in this paper we infer the flow from function. Neurons fire in response to stimuli and their firings vary relative to the intensities of the stimuli. We believe neurons use some kind of pairwise comparison mechanism to determine when to fire based on the stimuli they receive. The ideas we develop here about flows are used to deduce how a system based on this kind of firing determination works and can be described. Furthermore the firing of neurons requires continuous comparisons. To develop a formula describing the output of these pairwise comparisons requires solving Fredholm's equation of the second kind which is satisfied if and only if a simple functional equation has solutions. The Fourier transform of the real solution of this equation leads to inverse square laws like those that are common in physics. The Fourier transform applied to a complex valued solution leads to Dirac type of firings. Such firings are dense in the very general fields of functions known as Sobolev spaces and thus can be used to

  3. Gender Differences in Human Single Neuron Responses to Male Emotional Faces

    Directory of Open Access Journals (Sweden)

    Morgan eNewhoff

    2015-09-01

    Full Text Available Well-documented differences in the psychology and behavior of men and women have spurred extensive exploration of gender's role within the brain, particularly regarding emotional processing. While neuroanatomical studies clearly show differences between the sexes, the functional effects of these differences are less understood. Neuroimaging studies have shown inconsistent locations and magnitudes of gender differences in brain hemodynamic responses to emotion. To better understand the neurophysiology of these gender differences, we analyzed recordings of single neuron activity in the human brain as subjects of both genders viewed emotional expressions.This study included recordings of single-neuron activity of 14 (6 male epileptic patients in four brain areas: amygdala (236 neurons, hippocampus (n=270, anterior cingulate cortex (n=256, and ventromedial prefrontal cortex (n=174. Neural activity was recorded while participants viewed a series of avatar male faces portraying positive, negative or neutral expressions.Significant gender differences were found in the left amygdala, where 23% (n=15/66 of neurons in men were significantly affected by facial emotion, versus 8% (n=6/76 of neurons in women. A Fisher's exact test comparing the two ratios found a highly significant difference between the two (p<0.01. These results show specific differences between genders at the single-neuron level in the human amygdala. These differences may reflect gender-based distinctions in evolved capacities for emotional processing and also demonstrate the importance of including subject gender as an independent factor in future studies of emotional processing by single neurons in the human amygdala.

  4. Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity

    Science.gov (United States)

    Chiu, Isaac M; Barrett, Lee B; Williams, Erika K; Strochlic, David E; Lee, Seungkyu; Weyer, Andy D; Lou, Shan; Bryman, Gregory S; Roberson, David P; Ghasemlou, Nader; Piccoli, Cara; Ahat, Ezgi; Wang, Victor; Cobos, Enrique J; Stucky, Cheryl L; Ma, Qiufu; Liberles, Stephen D; Woolf, Clifford J

    2014-01-01

    The somatosensory nervous system is critical for the organism's ability to respond to mechanical, thermal, and nociceptive stimuli. Somatosensory neurons are functionally and anatomically diverse but their molecular profiles are not well-defined. Here, we used transcriptional profiling to analyze the detailed molecular signatures of dorsal root ganglion (DRG) sensory neurons. We used two mouse reporter lines and surface IB4 labeling to purify three major non-overlapping classes of neurons: 1) IB4+SNS-Cre/TdTomato+, 2) IB4−SNS-Cre/TdTomato+, and 3) Parv-Cre/TdTomato+ cells, encompassing the majority of nociceptive, pruriceptive, and proprioceptive neurons. These neurons displayed distinct expression patterns of ion channels, transcription factors, and GPCRs. Highly parallel qRT-PCR analysis of 334 single neurons selected by membership of the three populations demonstrated further diversity, with unbiased clustering analysis identifying six distinct subgroups. These data significantly increase our knowledge of the molecular identities of known DRG populations and uncover potentially novel subsets, revealing the complexity and diversity of those neurons underlying somatosensation. DOI: http://dx.doi.org/10.7554/eLife.04660.001 PMID:25525749

  5. Behavioral and Single-Neuron Sensitivity to Millisecond Variations in Temporally Patterned Communication Signals.

    Science.gov (United States)

    Baker, Christa A; Ma, Lisa; Casareale, Chelsea R; Carlson, Bruce A

    2016-08-24

    In many sensory pathways, central neurons serve as temporal filters for timing patterns in communication signals. However, how a population of neurons with diverse temporal filtering properties codes for natural variation in communication signals is unknown. Here we addressed this question in the weakly electric fish Brienomyrus brachyistius, which varies the time intervals between successive electric organ discharges to communicate. These fish produce an individually stereotyped signal called a scallop, which consists of a distinctive temporal pattern of ∼8-12 electric pulses. We manipulated the temporal structure of natural scallops during behavioral playback and in vivo electrophysiology experiments to probe the temporal sensitivity of scallop encoding and recognition. We found that presenting time-reversed, randomized, or jittered scallops increased behavioral response thresholds, demonstrating that fish's electric signaling behavior was sensitive to the precise temporal structure of scallops. Next, using in vivo intracellular recordings and discriminant function analysis, we found that the responses of interval-selective midbrain neurons were also sensitive to the precise temporal structure of scallops. Subthreshold changes in membrane potential recorded from single neurons discriminated natural scallops from time-reversed, randomized, and jittered sequences. Pooling the responses of multiple neurons improved the discriminability of natural sequences from temporally manipulated sequences. Finally, we found that single-neuron responses were sensitive to interindividual variation in scallop sequences, raising the question of whether fish may analyze scallop structure to gain information about the sender. Collectively, these results demonstrate that a population of interval-selective neurons can encode behaviorally relevant temporal patterns with millisecond precision. The timing patterns of action potentials, or spikes, play important roles in representing

  6. Relay Architectures for 3GPP LTE-Advanced

    Directory of Open Access Journals (Sweden)

    Peters StevenW

    2009-01-01

    Full Text Available The Third Generation Partnership Project's Long Term Evolution-Advanced is considering relaying for cost-effective throughput enhancement and coverage extension. While analog repeaters have been used to enhance coverage in commercial cellular networks, the use of more sophisticated fixed relays is relatively new. The main challenge faced by relay deployments in cellular systems is overcoming the extra interference added by the presence of relays. Most prior work on relaying does not consider interference, however. This paper analyzes the performance of several emerging half-duplex relay strategies in interference-limited cellular systems: one-way, two-way, and shared relays. The performance of each strategy as a function of location, sectoring, and frequency reuse are compared with localized base station coordination. One-way relaying is shown to provide modest gains over single-hop cellular networks in some regimes. Shared relaying is shown to approach the gains of local base station coordination at reduced complexity, while two-way relaying further reduces complexity but only works well when the relay is close to the handset. Frequency reuse of one, where each sector uses the same spectrum, is shown to have the highest network throughput. Simulations with realistic channel models provide performance comparisons that reveal the importance of interference mitigation in multihop cellular networks.

  7. The role of dendritic non-linearities in single neuron computation

    Directory of Open Access Journals (Sweden)

    Boris Gutkin

    2014-05-01

    Full Text Available Experiment has demonstrated that summation of excitatory post-synaptic protientials (EPSPs in dendrites is non-linear. The sum of multiple EPSPs can be larger than their arithmetic sum, a superlinear summation due to the opening of voltage-gated channels and similar to somatic spiking. The so-called dendritic spike. The sum of multiple of EPSPs can also be smaller than their arithmetic sum, because the synaptic current necessarily saturates at some point. While these observations are well-explained by biophysical models the impact of dendritic spikes on computation remains a matter of debate. One reason is that dendritic spikes may fail to make the neuron spike; similarly, dendritic saturations are sometime presented as a glitch which should be corrected by dendritic spikes. We will provide solid arguments against this claim and show that dendritic saturations as well as dendritic spikes enhance single neuron computation, even when they cannot directly make the neuron fire. To explore the computational impact of dendritic spikes and saturations, we are using a binary neuron model in conjunction with Boolean algebra. We demonstrate using these tools that a single dendritic non-linearity, either spiking or saturating, combined with somatic non-linearity, enables a neuron to compute linearly non-separable Boolean functions (lnBfs. These functions are impossible to compute when summation is linear and the exclusive OR is a famous example of lnBfs. Importantly, the implementation of these functions does not require the dendritic non-linearity to make the neuron spike. Next, We show that reduced and realistic biophysical models of the neuron are capable of computing lnBfs. Within these models and contrary to the binary model, the dendritic and somatic non-linearity are tightly coupled. Yet we show that these neuron models are capable of linearly non-separable computations.

  8. Towards a general theory of neural computation based on prediction by single neurons.

    Directory of Open Access Journals (Sweden)

    Christopher D Fiorillo

    Full Text Available Although there has been tremendous progress in understanding the mechanics of the nervous system, there has not been a general theory of its computational function. Here I present a theory that relates the established biophysical properties of single generic neurons to principles of Bayesian probability theory, reinforcement learning and efficient coding. I suggest that this theory addresses the general computational problem facing the nervous system. Each neuron is proposed to mirror the function of the whole system in learning to predict aspects of the world related to future reward. According to the model, a typical neuron receives current information about the state of the world from a subset of its excitatory synaptic inputs, and prior information from its other inputs. Prior information would be contributed by synaptic inputs representing distinct regions of space, and by different types of non-synaptic, voltage-regulated channels representing distinct periods of the past. The neuron's membrane voltage is proposed to signal the difference between current and prior information ("prediction error" or "surprise". A neuron would apply a Hebbian plasticity rule to select those excitatory inputs that are the most closely correlated with reward but are the least predictable, since unpredictable inputs provide the neuron with the most "new" information about future reward. To minimize the error in its predictions and to respond only when excitation is "new and surprising," the neuron selects amongst its prior information sources through an anti-Hebbian rule. The unique inputs of a mature neuron would therefore result from learning about spatial and temporal patterns in its local environment, and by extension, the external world. Thus the theory describes how the structure of the mature nervous system could reflect the structure of the external world, and how the complexity and intelligence of the system might develop from a population of

  9. Single-cell imaging of bioenergetic responses to neuronal excitotoxicity and oxygen and glucose deprivation.

    Science.gov (United States)

    Connolly, Niamh M C; Düssmann, Heiko; Anilkumar, Ujval; Huber, Heinrich J; Prehn, Jochen H M

    2014-07-30

    Excitotoxicity is a condition occurring during cerebral ischemia, seizures, and chronic neurodegeneration. It is characterized by overactivation of glutamate receptors, leading to excessive Ca(2+)/Na(+) influx into neurons, energetic stress, and subsequent neuronal injury. We and others have previously investigated neuronal populations to study how bioenergetic parameters determine neuronal injury; however, such experiments are often confounded by population-based heterogeneity and the contribution of effects of non-neuronal cells. Hence, we here characterized bioenergetics during transient excitotoxicity in rat and mouse primary neurons at the single-cell level using fluorescent sensors for intracellular glucose, ATP, and activation of the energy sensor AMP-activated protein kinase (AMPK). We identified ATP depletion and recovery to energetic homeostasis, along with AMPK activation, as surprisingly rapid and plastic responses in two excitotoxic injury paradigms. We observed rapid recovery of neuronal ATP levels also in the absence of extracellular glucose, or when glycolytic ATP production was inhibited, but found mitochondria to be critical for fast and complete energetic recovery. Using an injury model of oxygen and glucose deprivation, we identified a similarly rapid bioenergetics response, yet with incomplete ATP recovery and decreased AMPK activity. Interestingly, excitotoxicity also induced an accumulation of intracellular glucose, providing an additional source of energy during and after excitotoxicity-induced energy depletion. We identified this to originate from extracellular, AMPK-dependent glucose uptake and from intracellular glucose mobilization. Surprisingly, cells recovering their elevated glucose levels faster to baseline survived longer, indicating that the plasticity of neurons to adapt to bioenergetic challenges is a key indicator of neuronal viability. Copyright © 2014 the authors 0270-6474/14/3410192-14$15.00/0.

  10. Ensembles of gustatory cortical neurons anticipate and discriminate between tastants in a single lick

    Directory of Open Access Journals (Sweden)

    Jennifer R Stapleton

    2007-10-01

    Full Text Available The gustatory cortex (GC processes chemosensory and somatosensory information and is involved in learning and anticipation. Previously we found that a subpopulation of GC neurons responded to tastants in a single lick (Stapleton et al., 2006. Here we extend this investigation to determine if small ensembles of GC neurons, obtained while rats received blocks of tastants on a fixed ratio schedule (FR5, can discriminate between tastants and their concentrations after a single 50 µL delivery. In the FR5 schedule subjects received tastants every fifth (reinforced lick and the intervening licks were unreinforced. The ensemble firing patterns were analyzed with a Bayesian generalized linear model whose parameters included the firing rates and temporal patterns of the spike trains. We found that when both the temporal and rate parameters were included, 12 of 13 ensembles correctly identified single tastant deliveries. We also found that the activity during the unreinforced licks contained signals regarding the identity of the upcoming tastant, which suggests that GC neurons contain anticipatory information about the next tastant delivery. To support this finding we performed experiments in which tastant delivery was randomized within each block and found that the neural activity following the unreinforced licks did not predict the upcoming tastant. Collectively, these results suggest that after a single lick ensembles of GC neurons can discriminate between tastants, that they may utilize both temporal and rate information, and when the tastant delivery is repetitive ensembles contain information about the identity of the upcoming tastant delivery.

  11. Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1

    Directory of Open Access Journals (Sweden)

    Soham Chanda

    2014-08-01

    Full Text Available Direct conversion of nonneural cells to functional neurons holds great promise for neurological disease modeling and regenerative medicine. We previously reported rapid reprogramming of mouse embryonic fibroblasts (MEFs into mature induced neuronal (iN cells by forced expression of three transcription factors: ASCL1, MYT1L, and BRN2. Here, we show that ASCL1 alone is sufficient to generate functional iN cells from mouse and human fibroblasts and embryonic stem cells, indicating that ASCL1 is the key driver of iN cell reprogramming in different cell contexts and that the role of MYT1L and BRN2 is primarily to enhance the neuronal maturation process. ASCL1-induced single-factor neurons (1F-iN expressed mature neuronal markers, exhibited typical passive and active intrinsic membrane properties, and formed functional pre- and postsynaptic structures. Surprisingly, ASCL1-induced iN cells were predominantly excitatory, demonstrating that ASCL1 is permissive but alone not deterministic for the inhibitory neuronal lineage.

  12. Molecular hierarchy in neurons differentiated from mouse ES cells containing a single human chromosome 21.

    Science.gov (United States)

    Wang, Chi Chiu; Kadota, Mitsutaka; Nishigaki, Ryuichi; Kazuki, Yasuhiro; Shirayoshi, Yasuaki; Rogers, Michael Scott; Gojobori, Takashi; Ikeo, Kazuho; Oshimura, Mitsuo

    2004-02-06

    Defects in neurogenesis and neuronal differentiation in the fetal brain of Down syndrome (DS) patients lead to the apparent neuropathological abnormalities and contribute to the phenotypic characters of mental retardation, and premature development of Alzheimer's disease, those being the most common phenotype in DS. In order to understand the molecular mechanism underlying the cause of phenotypic abnormalities in the DS brain, we have utilized an in vitro model of TT2F mouse embryonic stem cells containing a single human chromosome 21 (hChr21) to study neuron development and neuronal differentiation by microarray containing 15K developmentally expressed cDNAs. Defective neuronal differentiation in the presence of extra hChr21 manifested primarily the post-transcriptional and translational modification, such as Mrpl10, SNAPC3, Srprb, SF3a60 in the early neuronal stem cell stage, and Mrps18a, Eef1g, and Ubce8 in the late differentiated stage. Hierarchical clustering patterned specific expression of hChr21 gene dosage effects on neuron outgrowth, migration, and differentiation, such as Syngr2, Dncic2, Eif3sf, and Peg3.

  13. Single-cell resolution mapping of neuronal damage in acute focal cerebral ischemia using thallium autometallography.

    Science.gov (United States)

    Stöber, Franziska; Baldauf, Kathrin; Ziabreva, Iryna; Harhausen, Denise; Zille, Marietta; Neubert, Jenni; Reymann, Klaus G; Scheich, Henning; Dirnagl, Ulrich; Schröder, Ulrich H; Wunder, Andreas; Goldschmidt, Jürgen

    2014-01-01

    Neuronal damage shortly after onset or after brief episodes of cerebral ischemia has remained difficult to assess with clinical and preclinical imaging techniques as well as with microscopical methods. We here show, in rodent models of middle cerebral artery occlusion (MCAO), that neuronal damage in acute focal cerebral ischemia can be mapped with single-cell resolution using thallium autometallography (TlAMG), a histochemical technique for the detection of the K(+)-probe thallium (Tl(+)) in the brain. We intravenously injected rats and mice with thallium diethyldithiocarbamate (TlDDC), a lipophilic chelate complex that releases Tl(+) after crossing the blood-brain barrier. We found, within the territories of the affected arteries, areas of markedly reduced neuronal Tl(+) uptake in all animals at all time points studied ranging from 15 minutes to 24 hours after MCAO. In large lesions at early time points, areas with neuronal and astrocytic Tl(+) uptake below thresholds of detection were surrounded by putative penumbral zones with preserved but diminished Tl(+) uptake. At 24 hours, the areas of reduced Tl(+)uptake matched with areas delineated by established markers of neuronal damage. The results suggest the use of (201)TlDDC for preclinical and clinical single-photon emission computed tomography (SPECT) imaging of hyperacute alterations in brain K(+) metabolism and prediction of tissue viability in cerebral ischemia.

  14. Neural Plasticity: Single Neuron Models for Discrimination and Generalization and AN Experimental Ensemble Approach.

    Science.gov (United States)

    Munro, Paul Wesley

    A special form for modification of neuronal response properties is described in which the change in the synaptic state vector is parallel to the vector of afferent activity. This process is termed "parallel modification" and its theoretical and experimental implications are examined. A theoretical framework has been devised to describe the complementary functions of generalization and discrimination by single neurons. This constitutes a basis for three models each describing processes for the development of maximum selectivity (discrimination) and minimum selectivity (generalization) by neurons. Strengthening and weakening of synapses is expressed as a product of the presynaptic activity and a nonlinear modulatory function of two postsynaptic variables--namely a measure of the spatially integrated activity of the cell and a temporal integration (time-average) of that activity. Some theorems are given for low-dimensional systems and computer simulation results from more complex systems are discussed. Model neurons that achieve high selectivity mimic the development of cat visual cortex neurons in a wide variety of rearing conditions. A role for low-selectivity neurons is proposed in which they provide inhibitory input to neurons of the opposite type, thereby suppressing the common component of a pattern class and enhancing their selective properties. Such contrast-enhancing circuits are analyzed and supported by computer simulation. To enable maximum selectivity, the net inhibition to a cell must become strong enough to offset whatever excitation is produced by the non-preferred patterns. Ramifications of parallel models for certain experimental paradigms are analyzed. A methodology is outlined for testing synaptic modification hypotheses in the laboratory. A plastic projection from one neuronal population to another will attain stable equilibrium under periodic electrical stimulation of constant intensity. The perturbative effect of shifting this intensity level

  15. Power system relaying

    CERN Document Server

    Horowitz, Stanley H; Niemira, James K

    2013-01-01

    The previous three editions of Power System Relaying offer comprehensive and accessible coverage of the theory and fundamentals of relaying and have been widely adopted on university and industry courses worldwide. With the third edition, the authors have added new and detailed descriptions of power system phenomena such as stability, system-wide protection concepts and discussion of historic outages. Power System Relaying, 4th Edition continues its role as an outstanding textbook on power system protection for senior and graduate students in the field of electric power engineering and a refer

  16. CERN Relay Race

    CERN Document Server

    2008-01-01

    The CERN relay race will take place around the Meyrin site on Thursday 5 June starting at 12:15 p.m. If possible, please avoid driving on the site during this 20-minute period. If you do meet runners while driving your car, please STOP until they have all passed. Thank you for your cooperation. Details on how to register your team for the relay race are given on the Staff Association Bulletin web site. You can access the online registration form at: http://cern.ch/club-running-relay/form.html

  17. CERN Relay Race

    CERN Document Server

    2007-01-01

    The CERN relay race will take place around the Meyrin site on Wednesday 23 May starting at 12:15. If possible, please avoid driving on the site during this 20-minute period. If you do meet runners while driving your car, please STOP until they have all passed. Thank you for your cooperation. Details on how to register your team for the relay race are given on the Staff Association Bulletin web site. You can access the online registration form at: http://cern.ch/club-running-relay/form.html

  18. Urethane anesthesia depresses activities of thalamocortical neurons and alters its response to nociception in terms of dual firing modes

    Directory of Open Access Journals (Sweden)

    Yeowool eHuh

    2013-10-01

    Full Text Available Anesthetics are often used to characterize the activity of single neurons in-vivo for its advantages such as reduced noise level and convenience in noxious stimulations. Of the anesthetics, urethane had been widely used in some thalamic studies under the assumption that sensory signals are still relayed to the thalamus under urethane anesthesia and that thalamic response would therefore reflect the response of the awake state. We tested whether this assumption stands by comparing thalamic activity in terms of tonic and burst firing modes during ‘the awake state’ or under ‘urethane anesthesia’ utilizing the extracellular single unit recording technique. First we have tested how thalamic relay neurons respond to the introduction of urethane and then tested how urethane influences thalamic discharges under formalin-induced nociception. Urethane significantly depressed overall firing rates of thalamic relay neurons, which was sustained despite the delayed increase of burst activity over the 4 hour recording period. Thalamic response to nociception under anesthesia was also similar overall except for the slight and transient increase of burst activity. Overall, results demonstrated that urethane suppresses the activity of thalamic relay neurons and that, despite the slight fluctuation of burst firing, formalin-induced nociception cannot significantly change the firing pattern of thalamic relay neurons that was caused by urethane.

  19. Automated quantification of neuronal networks and single-cell calcium dynamics using calcium imaging.

    Science.gov (United States)

    Patel, Tapan P; Man, Karen; Firestein, Bonnie L; Meaney, David F

    2015-03-30

    Recent advances in genetically engineered calcium and membrane potential indicators provide the potential to estimate the activation dynamics of individual neurons within larger, mesoscale networks (100s-1000+neurons). However, a fully integrated automated workflow for the analysis and visualization of neural microcircuits from high speed fluorescence imaging data is lacking. Here we introduce FluoroSNNAP, Fluorescence Single Neuron and Network Analysis Package. FluoroSNNAP is an open-source, interactive software developed in MATLAB for automated quantification of numerous biologically relevant features of both the calcium dynamics of single-cells and network activity patterns. FluoroSNNAP integrates and improves upon existing tools for spike detection, synchronization analysis, and inference of functional connectivity, making it most useful to experimentalists with little or no programming knowledge. We apply FluoroSNNAP to characterize the activity patterns of neuronal microcircuits undergoing developmental maturation in vitro. Separately, we highlight the utility of single-cell analysis for phenotyping a mixed population of neurons expressing a human mutant variant of the microtubule associated protein tau and wild-type tau. We show the performance of semi-automated cell segmentation using spatiotemporal independent component analysis and significant improvement in detecting calcium transients using a template-based algorithm in comparison to peak-based or wavelet-based detection methods. Our software further enables automated analysis of microcircuits, which is an improvement over existing methods. We expect the dissemination of this software will facilitate a comprehensive analysis of neuronal networks, promoting the rapid interrogation of circuits in health and disease. Copyright © 2015. Published by Elsevier B.V.

  20. Single bumps in a 2-population homogenized neuronal network model

    Science.gov (United States)

    Kolodina, Karina; Oleynik, Anna; Wyller, John

    2018-05-01

    We investigate existence and stability of single bumps in a homogenized 2-population neural field model, when the firing rate functions are given by the Heaviside function. The model is derived by means of the two-scale convergence technique of Nguetseng in the case of periodic microvariation in the connectivity functions. The connectivity functions are periodically modulated in both the synaptic footprint and in the spatial scale. The bump solutions are constructed by using a pinning function technique for the case where the solutions are independent of the local variable. In the weakly modulated case the generic picture consists of two bumps (one narrow and one broad bump) for each admissible set of threshold values for firing. In addition, a new threshold value regime for existence of bumps is detected. Beyond the weakly modulated regime the number of bumps depends sensitively on the degree of heterogeneity. For the latter case we present a configuration consisting of three coexisting bumps. The linear stability of the bumps is studied by means of the spectral properties of a Fredholm integral operator, block diagonalization of this operator and the Fourier decomposition method. In the weakly modulated regime, one of the bumps is unstable for all relative inhibition times, while the other one is stable for small and moderate values of this parameter. The latter bump becomes unstable as the relative inhibition time exceeds a certain threshold. In the case of the three coexisting bumps detected in the regime of finite degree of heterogeneity, we have at least one stable bump (and maximum two stable bumps) for small and moderate values of the relative inhibition time.

  1. A Route to Chaotic Behavior of Single Neuron Exposed to External Electromagnetic Radiation.

    Science.gov (United States)

    Feng, Peihua; Wu, Ying; Zhang, Jiazhong

    2017-01-01

    Non-linear behaviors of a single neuron described by Fitzhugh-Nagumo (FHN) neuron model, with external electromagnetic radiation considered, is investigated. It is discovered that with external electromagnetic radiation in form of a cosine function, the mode selection of membrane potential occurs among periodic, quasi-periodic, and chaotic motions as increasing the frequency of external transmembrane current, which is selected as a sinusoidal function. When the frequency is small or large enough, periodic, and quasi-periodic motions are captured alternatively. Otherwise, when frequency is in interval 0.778 electromagnetic radiation. The frequency apparently plays a more important role in determining the system behavior.

  2. Value encoding in single neurons in the human amygdala during decision making.

    Science.gov (United States)

    Jenison, Rick L; Rangel, Antonio; Oya, Hiroyuki; Kawasaki, Hiroto; Howard, Matthew A

    2011-01-05

    A growing consensus suggests that the brain makes simple choices by assigning values to the stimuli under consideration and then comparing these values to make a decision. However, the network involved in computing the values has not yet been fully characterized. Here, we investigated whether the human amygdala plays a role in the computation of stimulus values at the time of decision making. We recorded single neuron activity from the amygdala of awake patients while they made simple purchase decisions over food items. We found 16 amygdala neurons, located primarily in the basolateral nucleus that responded linearly to the values assigned to individual items.

  3. Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus.

    Science.gov (United States)

    Hernández, Vivian M; Hegeman, Daniel J; Cui, Qiaoling; Kelver, Daniel A; Fiske, Michael P; Glajch, Kelly E; Pitt, Jason E; Huang, Tina Y; Justice, Nicholas J; Chan, C Savio

    2015-08-26

    Compelling evidence suggests that pathological activity of the external globus pallidus (GPe), a nucleus in the basal ganglia, contributes to the motor symptoms of a variety of movement disorders such as Parkinson's disease. Recent studies have challenged the idea that the GPe comprises a single, homogenous population of neurons that serves as a simple relay in the indirect pathway. However, we still lack a full understanding of the diversity of the neurons that make up the GPe. Specifically, a more precise classification scheme is needed to better describe the fundamental biology and function of different GPe neuron classes. To this end, we generated a novel multicistronic BAC (bacterial artificial chromosome) transgenic mouse line under the regulatory elements of the Npas1 gene. Using a combinatorial transgenic and immunohistochemical approach, we discovered that parvalbumin-expressing neurons and Npas1-expressing neurons in the GPe represent two nonoverlapping cell classes, amounting to 55% and 27% of the total GPe neuron population, respectively. These two genetically identified cell classes projected primarily to the subthalamic nucleus and to the striatum, respectively. Additionally, parvalbumin-expressing neurons and Npas1-expressing neurons were distinct in their autonomous and driven firing characteristics, their expression of intrinsic ion conductances, and their responsiveness to chronic 6-hydroxydopamine lesion. In summary, our data argue that parvalbumin-expressing neurons and Npas1-expressing neurons are two distinct functional classes of GPe neurons. This work revises our understanding of the GPe, and provides the foundation for future studies of its function and dysfunction. Until recently, the heterogeneity of the constituent neurons within the external globus pallidus (GPe) was not fully appreciated. We addressed this knowledge gap by discovering two principal GPe neuron classes, which were identified by their nonoverlapping expression of the

  4. Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus

    Science.gov (United States)

    Hernández, Vivian M.; Hegeman, Daniel J.; Cui, Qiaoling; Kelver, Daniel A.; Fiske, Michael P.; Glajch, Kelly E.; Pitt, Jason E.; Huang, Tina Y.; Justice, Nicholas J.

    2015-01-01

    Compelling evidence suggests that pathological activity of the external globus pallidus (GPe), a nucleus in the basal ganglia, contributes to the motor symptoms of a variety of movement disorders such as Parkinson's disease. Recent studies have challenged the idea that the GPe comprises a single, homogenous population of neurons that serves as a simple relay in the indirect pathway. However, we still lack a full understanding of the diversity of the neurons that make up the GPe. Specifically, a more precise classification scheme is needed to better describe the fundamental biology and function of different GPe neuron classes. To this end, we generated a novel multicistronic BAC (bacterial artificial chromosome) transgenic mouse line under the regulatory elements of the Npas1 gene. Using a combinatorial transgenic and immunohistochemical approach, we discovered that parvalbumin-expressing neurons and Npas1-expressing neurons in the GPe represent two nonoverlapping cell classes, amounting to 55% and 27% of the total GPe neuron population, respectively. These two genetically identified cell classes projected primarily to the subthalamic nucleus and to the striatum, respectively. Additionally, parvalbumin-expressing neurons and Npas1-expressing neurons were distinct in their autonomous and driven firing characteristics, their expression of intrinsic ion conductances, and their responsiveness to chronic 6-hydroxydopamine lesion. In summary, our data argue that parvalbumin-expressing neurons and Npas1-expressing neurons are two distinct functional classes of GPe neurons. This work revises our understanding of the GPe, and provides the foundation for future studies of its function and dysfunction. SIGNIFICANCE STATEMENT Until recently, the heterogeneity of the constituent neurons within the external globus pallidus (GPe) was not fully appreciated. We addressed this knowledge gap by discovering two principal GPe neuron classes, which were identified by their nonoverlapping

  5. Relay testing parametric investigation of seismic fragility

    International Nuclear Information System (INIS)

    Bandyopadhyay, K.; Hofmayer, C.; Kassir, M.; Pepper, S.

    1989-01-01

    The seismic capacity of most electrical equipment is governed by malfunction of relays. An evaluation of the existing relay test data base at Brookhaven National Laboratory (BNL) has indicated that the seismic fragility of a relay may depend on various parameters related to the design or the input motion. In particular, the electrical mode, contact state, adjustment, chatter duration acceptance limit, and the frequency and the direction of the vibration input have been considered to influence the relay fragility level. For a particular relay type, the dynamics of its moving parts depends on the exact model number and vintage and hence, these parameters may also influence the fragility level. In order to investigate the effect of most of these parameters on the seismic fragility level, BNL has conducted a relay test program. The testing has been performed at Wyle Laboratories. Establishing the correlation between the single frequency fragility test input and the corresponding multifrequency response spectrum (TRS) is also an objective of this test program. This paper discusses the methodology used for testing and presents a brief summary of important test results. 1 ref., 10 figs

  6. Ready, steady… relay!

    CERN Multimedia

    2008-01-01

    Thursday 5 June. With another year comes another success for CERN’s Relay Race. With 76 teams taking part it was the second highest turnout in the race’s history. ‘The Shabbys’ won the relay race in 10 minutes 51 seconds.As popular as ever, this year the relay race took on the atmosphere of a mini carnival. Gathering on the lawn outside Restaurant 1, various stalls and attractions added to the party feeling of the event, with beer courtesy of ‘AGLUP’, the Belgian beer club, and a wandering jazz group entertaining spectators and competitors alike. Reflecting the greater involvement of other associations in the relay race, the president of the Staff Association Clubs Committee, James Purvis, was the guest of honour, launching the start of the race and presenting the prizes. As regular followers of the race could have probably predicted, The Shabbys were once again victorious and claimed first place. The team members th...

  7. CERN Relay Race 2009

    CERN Document Server

    2009-01-01

    The CERN relay race will take place around the Meyrin site on Thursday 14th May starting at 12:15. If possible, please avoid driving on the site during this 20-minute period. If you do meet runners while driving your car, please STOP until they have all passed. Thank you for your cooperation. More details on how to register your team for the relay race

  8. CERN Relay Race

    CERN Document Server

    2006-01-01

    The CERN relay race will take place around the Meyrin site on Wednesday 17 May starting at 12:15. If possible, please avoid driving on the site during this 20-minute period. If you do meet runners while driving your car, please STOP until they have all passed. Details on how to register your team for the relay race are given on the Staff Association Bulletin web site.

  9. Modular relay control

    OpenAIRE

    Ivarsson, Mikael

    2010-01-01

    Enics Sweden AB, Västerås, is an electronics manufacturing services company with its main business in manufacturing electronics. Most, if not all, electronic devices that are manufactured are being widely tested before delivery to ensure proper functionality. Often during tests a large number of signals are measured by one to a few digital multimeters and are therefore controlled through relays. Relays are also used when applying stimuli with high currents or voltages to the unit under test. ...

  10. Opportunistic relaying in multipath and slow fading channel: Relay selection and optimal relay selection period

    KAUST Repository

    Sungjoon Park,

    2011-11-01

    In this paper we present opportunistic relay communication strategies of decode and forward relaying. The channel that we are considering includes pathloss, shadowing, and fast fading effects. We find a simple outage probability formula for opportunistic relaying in the channel, and validate the results by comparing it with the exact outage probability. Also, we suggest a new relay selection algorithm that incorporates shadowing. We consider a protocol of broadcasting the channel gain of the previously selected relay. This saves resources in slow fading channel by reducing collisions in relay selection. We further investigate the optimal relay selection period to maximize the throughput while avoiding selection overhead. © 2011 IEEE.

  11. Scalable DeNoise-and-Forward in Bidirectional Relay Networks

    DEFF Research Database (Denmark)

    Sørensen, Jesper Hemming; Krigslund, Rasmus; Popovski, Petar

    2010-01-01

    In this paper a scalable relaying scheme is proposed based on an existing concept called DeNoise-and-Forward, DNF. We call it Scalable DNF, S-DNF, and it targets the scenario with multiple communication flows through a single common relay. The idea of the scheme is to combine packets at the relay...... in order to save transmissions. To ensure decodability at the end-nodes, a priori information about the content of the combined packets must be available. This is gathered during the initial transmissions to the relay. The trade-off between decodability and number of necessary transmissions is analysed...

  12. Amplify-and-forward relaying in wireless communications

    CERN Document Server

    Rodriguez, Leonardo Jimenez; Le-Ngoc, Tho

    2015-01-01

    This SpringerBrief explores the advantage of relaying techniques in addressing the increasing demand for high data rates and reliable services over the air. It demonstrates how to design cost-effective relay systems that provide high spectral efficiency and fully exploit the diversity of the relay channel. The brief covers advances in achievable rates, power allocation schemes, and error performance for half-duplex (HD) and full-duplex (FD) amplify-and-forward (AF) single-relay systems. The authors discuss the capacity and respective optimal power allocation for a wide range of HD protocols ov

  13. Generalized instantly decodable network coding for relay-assisted networks

    KAUST Repository

    Elmahdy, Adel M.

    2013-09-01

    In this paper, we investigate the problem of minimizing the frame completion delay for Instantly Decodable Network Coding (IDNC) in relay-assisted wireless multicast networks. We first propose a packet recovery algorithm in the single relay topology which employs generalized IDNC instead of strict IDNC previously proposed in the literature for the same relay-assisted topology. This use of generalized IDNC is supported by showing that it is a super-set of the strict IDNC scheme, and thus can generate coding combinations that are at least as efficient as strict IDNC in reducing the average completion delay. We then extend our study to the multiple relay topology and propose a joint generalized IDNC and relay selection algorithm. This proposed algorithm benefits from the reception diversity of the multiple relays to further reduce the average completion delay in the network. Simulation results show that our proposed solutions achieve much better performance compared to previous solutions in the literature. © 2013 IEEE.

  14. Relaying Strategies and Protocols for Efficient Wireless Networks

    KAUST Repository

    Zafar, Ammar

    2014-10-01

    Next generation wireless networks are expected to provide high data rate and satisfy the Quality-of-Service (QoS) constraints of the users. A significant component of achieving these goals is to increase the effi ciency of wireless networks by either optimizing current architectures or exploring new technologies which achieve that. The latter includes revisiting technologies which were previously proposed, but due to a multitude of reasons were ignored at that time. One such technology is relaying which was initially proposed in the latter half of the 1960s and then was revived in the early 2000s. In this dissertation, we study relaying in conjunction with resource allocation to increase the effi ciency of wireless networks. In this regard, we differentiate between conventional relaying and relaying with buffers. Conventional relaying is traditional relaying where the relay forwards the signal it received immediately. On the other hand, in relaying with buffers or buffer-aided relaying as it is called, the relay can store received data in its buffer and forward it later on. This gives the benefit of taking advantage of good channel conditions as the relay can only transmit when the channel conditions are good. The dissertation starts with conventional relaying and considers the problem of minimizing the total consumed power while maintaining system QoS. After upper bounding the system performance, more practical algorithms which require reduced feedback overhead are explored. Buffer-aided relaying is then considered and the joint user-and-hop scheduler is introduced which exploits multi-user diversity (MUD) and 5 multi-hop diversity (MHD) gains together in dual-hop broadcast channels. Next joint user-and-hop scheduling is extended to the shared relay channel where two source-destination pairs share a single relay. The benefits of buffer-aided relaying in the bidirectional relay channel utilizing network coding are then explored. Finally, a new transmission protocol

  15. Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity

    Science.gov (United States)

    Li, Chang-Lin; Li, Kai-Cheng; Wu, Dan; Chen, Yan; Luo, Hao; Zhao, Jing-Rong; Wang, Sa-Shuang; Sun, Ming-Ming; Lu, Ying-Jin; Zhong, Yan-Qing; Hu, Xu-Ye; Hou, Rui; Zhou, Bei-Bei; Bao, Lan; Xiao, Hua-Sheng; Zhang, Xu

    2016-01-01

    Sensory neurons are distinguished by distinct signaling networks and receptive characteristics. Thus, sensory neuron types can be defined by linking transcriptome-based neuron typing with the sensory phenotypes. Here we classify somatosensory neurons of the mouse dorsal root ganglion (DRG) by high-coverage single-cell RNA-sequencing (10 950 ± 1 218 genes per neuron) and neuron size-based hierarchical clustering. Moreover, single DRG neurons responding to cutaneous stimuli are recorded using an in vivo whole-cell patch clamp technique and classified by neuron-type genetic markers. Small diameter DRG neurons are classified into one type of low-threshold mechanoreceptor and five types of mechanoheat nociceptors (MHNs). Each of the MHN types is further categorized into two subtypes. Large DRG neurons are categorized into four types, including neurexophilin 1-expressing MHNs and mechanical nociceptors (MNs) expressing BAI1-associated protein 2-like 1 (Baiap2l1). Mechanoreceptors expressing trafficking protein particle complex 3-like and Baiap2l1-marked MNs are subdivided into two subtypes each. These results provide a new system for cataloging somatosensory neurons and their transcriptome databases. PMID:26691752

  16. Multiplicative mixing of object identity and image attributes in single inferior temporal neurons.

    Science.gov (United States)

    Ratan Murty, N Apurva; Arun, S P

    2018-04-03

    Object recognition is challenging because the same object can produce vastly different images, mixing signals related to its identity with signals due to its image attributes, such as size, position, rotation, etc. Previous studies have shown that both signals are present in high-level visual areas, but precisely how they are combined has remained unclear. One possibility is that neurons might encode identity and attribute signals multiplicatively so that each can be efficiently decoded without interference from the other. Here, we show that, in high-level visual cortex, responses of single neurons can be explained better as a product rather than a sum of tuning for object identity and tuning for image attributes. This subtle effect in single neurons produced substantially better population decoding of object identity and image attributes in the neural population as a whole. This property was absent both in low-level vision models and in deep neural networks. It was also unique to invariances: when tested with two-part objects, neural responses were explained better as a sum than as a product of part tuning. Taken together, our results indicate that signals requiring separate decoding, such as object identity and image attributes, are combined multiplicatively in IT neurons, whereas signals that require integration (such as parts in an object) are combined additively. Copyright © 2018 the Author(s). Published by PNAS.

  17. Audio-vocal interaction in single neurons of the monkey ventrolateral prefrontal cortex.

    Science.gov (United States)

    Hage, Steffen R; Nieder, Andreas

    2015-05-06

    Complex audio-vocal integration systems depend on a strong interconnection between the auditory and the vocal motor system. To gain cognitive control over audio-vocal interaction during vocal motor control, the PFC needs to be involved. Neurons in the ventrolateral PFC (VLPFC) have been shown to separately encode the sensory perceptions and motor production of vocalizations. It is unknown, however, whether single neurons in the PFC reflect audio-vocal interactions. We therefore recorded single-unit activity in the VLPFC of rhesus monkeys (Macaca mulatta) while they produced vocalizations on command or passively listened to monkey calls. We found that 12% of randomly selected neurons in VLPFC modulated their discharge rate in response to acoustic stimulation with species-specific calls. Almost three-fourths of these auditory neurons showed an additional modulation of their discharge rates either before and/or during the monkeys' motor production of vocalization. Based on these audio-vocal interactions, the VLPFC might be well positioned to combine higher order auditory processing with cognitive control of the vocal motor output. Such audio-vocal integration processes in the VLPFC might constitute a precursor for the evolution of complex learned audio-vocal integration systems, ultimately giving rise to human speech. Copyright © 2015 the authors 0270-6474/15/357030-11$15.00/0.

  18. Variations in interpulse interval of double action potentials during propagation in single neurons.

    Science.gov (United States)

    Villagran-Vargas, Edgar; Rodríguez-Sosa, Leonardo; Hustert, Reinhold; Blicher, Andreas; Laub, Katrine; Heimburg, Thomas

    2013-02-01

    In this work, we analyzed the interpulse interval (IPI) of doublets and triplets in single neurons of three biological models. Pulse trains with two or three spikes originate from the process of sensory mechanotransduction in neurons of the locust femoral nerve, as well as through spontaneous activity both in the abdominal motor neurons and the caudal photoreceptor of the crayfish. We show that the IPI for successive low-frequency single action potentials, as recorded with two electrodes at two different points along a nerve axon, remains constant. On the other hand, IPI in doublets either remains constant, increases or decreases by up to about 3 ms as the pair propagates. When IPI increases, the succeeding pulse travels at a slower speed than the preceding one. When IPI is reduced, the succeeding pulse travels faster than the preceding one and may exceed the normal value for the specific neuron. In both cases, IPI increase and reduction, the speed of the preceding pulse differs slightly from the normal value, therefore the two pulses travel at different speeds in the same nerve axon. On the basis of our results, we may state that the effect of attraction or repulsion in doublets suggests a tendency of the spikes to reach a stable configuration. We strongly suggest that the change in IPI during spike propagation of doublets opens up a whole new realm of possibilities for neural coding and may have major implications for understanding information processing in nervous systems. Copyright © 2012 Wiley Periodicals, Inc.

  19. Two-Way Multi-Antenna Relaying with Simultaneous Wireless Information and Power Transfer

    Directory of Open Access Journals (Sweden)

    Thanaphat Srivantana

    2017-03-01

    Full Text Available In this paper, we propose various kinds of two-way multi-antenna relaying with simultaneous wireless information and power transfer (SWIPT and investigate their performance. Specifically, we first consider a two-way relay network where two single-antenna end nodes communicate with each other through a multi-antenna relay node that is energy constrained. This relay node harvests energy from the two end nodes and use the harvested energy for forwarding their information. Six relaying schemes that support the considered network then build on the power splitting-based relaying and time switching-based relaying protocols. The average bit error rates of these schemes are evaluated and compared by computer simulations considering several network parameters, including the number of relay antennas, power splitting ratio, and energy harvesting time. Such evaluation and comparison provide useful insights into the performance of SWIPT-based two-way multi-antenna relaying.

  20. Individual mediodorsal thalamic neurons project to multiple areas of the rat prefrontal cortex: A single neuron-tracing study using virus vectors.

    Science.gov (United States)

    Kuramoto, Eriko; Pan, Shixiu; Furuta, Takahiro; Tanaka, Yasuhiro R; Iwai, Haruki; Yamanaka, Atsushi; Ohno, Sachi; Kaneko, Takeshi; Goto, Tetsuya; Hioki, Hiroyuki

    2017-01-01

    The prefrontal cortex has an important role in a variety of cognitive and executive processes, and is generally defined by its reciprocal connections with the mediodorsal thalamic nucleus (MD). The rat MD is mainly subdivided into three segments, the medial (MDm), central (MDc), and lateral (MDl) divisions, on the basis of the cytoarchitecture and chemoarchitecture. The MD segments are known to topographically project to multiple prefrontal areas at the population level: the MDm mainly to the prelimbic, infralimbic, and agranular insular areas; the MDc to the orbital and agranular insular areas; and the MDl to the prelimbic and anterior cingulate areas. However, it is unknown whether individual MD neurons project to single or multiple prefrontal cortical areas. In the present study, we visualized individual MD neurons with Sindbis virus vectors, and reconstructed whole structures of MD neurons. While the main cortical projection targets of MDm, MDc, and MDl neurons were generally consistent with those of previous results, it was found that individual MD neurons sent their axon fibers to multiple prefrontal areas, and displayed various projection patterns in the target areas. Furthermore, the axons of single MD neurons were not homogeneously spread, but were rather distributed to form patchy axon arbors approximately 1 mm in diameter. The multiple-area projections and patchy axon arbors of single MD neurons might be able to coactivate cortical neuron groups in distant prefrontal areas simultaneously. Furthermore, considerable heterogeneity of the projection patterns is likely, to recruit the different sets of cortical neurons, and thus contributes to a variety of prefrontal functions. J. Comp. Neurol. 525:166-185, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  1. Recording single neurons' action potentials from freely moving pigeons across three stages of learning.

    Science.gov (United States)

    Starosta, Sarah; Stüttgen, Maik C; Güntürkün, Onur

    2014-06-02

    While the subject of learning has attracted immense interest from both behavioral and neural scientists, only relatively few investigators have observed single-neuron activity while animals are acquiring an operantly conditioned response, or when that response is extinguished. But even in these cases, observation periods usually encompass only a single stage of learning, i.e. acquisition or extinction, but not both (exceptions include protocols employing reversal learning; see Bingman et al.(1) for an example). However, acquisition and extinction entail different learning mechanisms and are therefore expected to be accompanied by different types and/or loci of neural plasticity. Accordingly, we developed a behavioral paradigm which institutes three stages of learning in a single behavioral session and which is well suited for the simultaneous recording of single neurons' action potentials. Animals are trained on a single-interval forced choice task which requires mapping each of two possible choice responses to the presentation of different novel visual stimuli (acquisition). After having reached a predefined performance criterion, one of the two choice responses is no longer reinforced (extinction). Following a certain decrement in performance level, correct responses are reinforced again (reacquisition). By using a new set of stimuli in every session, animals can undergo the acquisition-extinction-reacquisition process repeatedly. Because all three stages of learning occur in a single behavioral session, the paradigm is ideal for the simultaneous observation of the spiking output of multiple single neurons. We use pigeons as model systems, but the task can easily be adapted to any other species capable of conditioned discrimination learning.

  2. Coexisting chaotic attractors in a single neuron model with adapting feedback synapse

    International Nuclear Information System (INIS)

    Li Chunguang; Chen Guanrong

    2005-01-01

    In this paper, we consider the nonlinear dynamical behavior of a single neuron model with adapting feedback synapse, and show that chaotic behaviors exist in this model. In some parameter domain, we observe two coexisting chaotic attractors, switching from the coexisting chaotic attractors to a connected chaotic attractor, and then switching back to the two coexisting chaotic attractors. We confirm the chaoticity by simulations with phase plots, waveform plots, and power spectra

  3. Phase Locking of Multiple Single Neurons to the Local Field Potential in Cat V1.

    Science.gov (United States)

    Martin, Kevan A C; Schröder, Sylvia

    2016-02-24

    The local field potential (LFP) is thought to reflect a temporal reference for neuronal spiking, which may facilitate information coding and orchestrate the communication between neural populations. To explore this proposed role, we recorded the LFP and simultaneously the spike activity of one to three nearby neurons in V1 of anesthetized cats during the presentation of drifting sinusoidal gratings, binary dense noise stimuli, and natural movies. In all stimulus conditions and during spontaneous activity, the average LFP power at frequencies >20 Hz was higher when neurons were spiking versus not spiking. The spikes were weakly but significantly phase locked to all frequencies of the LFP. The average spike phase of the LFP was stable across high and low levels of LFP power, but the strength of phase locking at low frequencies (≤10 Hz) increased with increasing LFP power. In a next step, we studied how strong stimulus responses of single neurons are reflected in the LFP and the LFP-spike relationship. We found that LFP power was slightly increased and phase locking was slightly stronger during strong compared with weak stimulus-locked responses. In summary, the coupling strength between high frequencies of the LFP and spikes was not strongly modulated by LFP power, which is thought to reflect spiking synchrony, nor was it strongly influenced by how strongly the neuron was driven by the stimulus. Furthermore, a comparison between neighboring neurons showed no clustering of preferred LFP phase. We argue that hypotheses on the relevance of phase locking in their current form are inconsistent with our findings. Copyright © 2016 the authors 0270-6474/16/362494-09$15.00/0.

  4. Effects of dynamic synapses on noise-delayed response latency of a single neuron

    Science.gov (United States)

    Uzuntarla, M.; Ozer, M.; Ileri, U.; Calim, A.; Torres, J. J.

    2015-12-01

    The noise-delayed decay (NDD) phenomenon emerges when the first-spike latency of a periodically forced stochastic neuron exhibits a maximum for a particular range of noise intensity. Here, we investigate the latency response dynamics of a single Hodgkin-Huxley neuron that is subject to both a suprathreshold periodic stimulus and a background activity arriving through dynamic synapses. We study the first-spike latency response as a function of the presynaptic firing rate f . This constitutes a more realistic scenario than previous works, since f provides a suitable biophysically realistic parameter to control the level of activity in actual neural systems. We first report on the emergence of classical NDD behavior as a function of f for the limit of static synapses. Second, we show that when short-term depression and facilitation mechanisms are included at the synapses, different NDD features can be found due to their modulatory effect on synaptic current fluctuations. For example, an intriguing double NDD (DNDD) behavior occurs for different sets of relevant synaptic parameters. Moreover, depending on the balance between synaptic depression and synaptic facilitation, single NDD or DNDD can prevail, in such a way that synaptic facilitation favors the emergence of DNDD whereas synaptic depression favors the existence of single NDD. Here we report the existence of the DNDD effect in the response latency dynamics of a neuron.

  5. Long-term memory in Aplysia modulates the total number of varicosities of single identified sensory neurons.

    OpenAIRE

    Bailey, C H; Chen, M

    1988-01-01

    The morphological consequences of long-term habituation and sensitization of the gill withdrawal reflex in Aplysia california were explored by examining the total number of presynaptic varicosities of single identified sensory neurons (a critical site of plasticity for the biochemical and biophysical changes that underlie both types of learning) in control and behaviorally trained animals. Sensory neurons from habituated animals had 35% fewer synaptic varicosities than did sensory neurons fro...

  6. A low complexity algorithm for multiple relay selection in two-way relaying Cognitive Radio networks

    KAUST Repository

    Alsharoa, Ahmad M.

    2013-06-01

    In this paper, a multiple relay selection scheme for two-way relaying cognitive radio network is investigated. We consider a cooperative Cognitive Radio (CR) system with spectrum sharing scenario using Amplify-and-Forward (AF) protocol, where licensed users and unlicensed users operate on the same frequency band. The main objective is to maximize the sum rate of the unlicensed users allowed to share the spectrum with the licensed users by respecting a tolerated interference threshold. A practical low complexity heuristic approach is proposed to solve our formulated optimization problem. Selected numerical results show that the proposed algorithm reaches a performance close to the performance of the optimal multiple relay selection scheme either with discrete or continuous power distributions while providing a considerable saving in terms of computational complexity. In addition, these results show that our proposed scheme significantly outperforms the single relay selection scheme. © 2013 IEEE.

  7. Optimal relay selection and power allocation for cognitive two-way relaying networks

    KAUST Repository

    Pandarakkottilil, Ubaidulla

    2012-06-01

    In this paper, we present an optimal scheme for power allocation and relay selection in a cognitive radio network where a pair of cognitive (or secondary) transceiver nodes communicate with each other assisted by a set of cognitive two-way relays. The secondary nodes share the spectrum with a licensed primary user (PU), and each node is assumed to be equipped with a single transmit/receive antenna. The interference to the PU resulting from the transmission from the cognitive nodes is kept below a specified limit. We propose joint relay selection and optimal power allocation among the secondary user (SU) nodes achieving maximum throughput under transmit power and PU interference constraints. A closed-form solution for optimal allocation of transmit power among the SU transceivers and the SU relay is presented. Furthermore, numerical simulations and comparisons are presented to illustrate the performance of the proposed scheme. © 2012 IEEE.

  8. SWIPT in Multiuser MIMO Decode-and-Forward Relay Broadcasting Channel with Energy Harvesting Relays

    KAUST Repository

    Benkhelifa, Fatma

    2017-02-09

    In this paper, we consider a multiuser multiple- input multiple-output (MIMO) decode-and-forward (DF) relay broadcasting channel (BC) with single source, multiple energy harvesting relays and multiple destinations. Since the end-to-end sum rate maximization problem is intractable, we tackle a simplified problem where we maximize the sum of the harvested energy at the relays, we employ the block diagonalization (BD) procedure at the source, and we mitigate the interference between the relay- destination channels. The interference mitigation at the destinations is managed in two ways: either to fix the interference covariance matrices at the destination and update them at each iteration until convergence, or to cancel the interference using an algorithm similar to the BD method. We provide numerical results to show the relevance of our proposed solution.

  9. Alternate MIMO relaying with three AF relays using interference alignment

    KAUST Repository

    Park, Kihong

    2012-06-01

    In this paper, we study a two-hop half-duplex relaying network with one source, one destination, and three amplify-and-forward (AF) relays equipped with M antennas each. We consider alternate transmission to compensate for the inherent loss of capacity pre-log factor 1/2 in half duplex mode, where source transmit message to two relays and the other relay alternately. The inter-relay interference caused by alternate transmission is aligned to make additional degrees of freedom (DOFs). It is shown that the proposed scheme enables us to exploit 3M/4 DOFs compared with the M/2 DOFs of conventional AF relaying. More specifically, suboptimal linear filter designs for a source and three relays are proposed to maximize the achievable sum-rate. We verify using some selected numerical results that the proposed filter designs give significant improvement of the sum-rate over a naive filter and conventional relaying schemes. © 2012 IEEE.

  10. Contribution of LFP dynamics to single-neuron spiking variability in motor cortex during movement execution

    Science.gov (United States)

    Rule, Michael E.; Vargas-Irwin, Carlos; Donoghue, John P.; Truccolo, Wilson

    2015-01-01

    Understanding the sources of variability in single-neuron spiking responses is an important open problem for the theory of neural coding. This variability is thought to result primarily from spontaneous collective dynamics in neuronal networks. Here, we investigate how well collective dynamics reflected in motor cortex local field potentials (LFPs) can account for spiking variability during motor behavior. Neural activity was recorded via microelectrode arrays implanted in ventral and dorsal premotor and primary motor cortices of non-human primates performing naturalistic 3-D reaching and grasping actions. Point process models were used to quantify how well LFP features accounted for spiking variability not explained by the measured 3-D reach and grasp kinematics. LFP features included the instantaneous magnitude, phase and analytic-signal components of narrow band-pass filtered (δ,θ,α,β) LFPs, and analytic signal and amplitude envelope features in higher-frequency bands. Multiband LFP features predicted single-neuron spiking (1ms resolution) with substantial accuracy as assessed via ROC analysis. Notably, however, models including both LFP and kinematics features displayed marginal improvement over kinematics-only models. Furthermore, the small predictive information added by LFP features to kinematic models was redundant to information available in fast-timescale (spiking history. Overall, information in multiband LFP features, although predictive of single-neuron spiking during movement execution, was redundant to information available in movement parameters and spiking history. Our findings suggest that, during movement execution, collective dynamics reflected in motor cortex LFPs primarily relate to sensorimotor processes directly controlling movement output, adding little explanatory power to variability not accounted by movement parameters. PMID:26157365

  11. Relay test program

    International Nuclear Information System (INIS)

    Bandyopadhyay, K.K.; Kunkel, C.; Shteyngart, S.

    1994-02-01

    This report presents the results of a relay test program conducted by Brookhaven National Laboratory (BNL) under the sponsorship of the US Nuclear Regulatory Commission (NRC). The program is a continuation of an earlier test program the results of which were published in NUREG/CR-4867. The current program was carried out in two phases: electrical testing and vibration testing. The objective was primarily to focus on the electrical discontinuity or continuity of relays and circuit breaker tripping mechanisms subjected to electrical pulses and vibration loads. The electrical testing was conducted by KEMA-Powertest Company and the vibration testing was performed at Wyle Laboratories, Huntsville, Alabama. This report discusses the test procedures, presents the test data, includes an analysis of the data and provides recommendations regarding reliable relay testing

  12. Whether and Where to Code in the Wireless Relay Channel

    DEFF Research Database (Denmark)

    Shi, Xiaomeng; Médard, Muriel; Roetter, Daniel Enrique Lucani

    2013-01-01

    The throughput benefits of random linear network codes have been studied extensively for wirelined and wireless erasure networks. It is often assumed that all nodes within a network perform coding operations. In energy-constrained systems, however, coding subgraphs should be chosen to control...... the number of coding nodes while maintaining throughput. In this paper, we explore the strategic use of network coding in the wireless packet erasure relay channel according to both throughput and energy metrics. In the relay channel, a single source communicates to a single sink through the aid of a half......-duplex relay. The fluid flow model is used to describe the case where both the source and the relay are coding, and Markov chain models are proposed to describe packet evolution if only the source or only the relay is coding. In addition to transmission energy, we take into account coding and reception...

  13. CERN Relay Race

    CERN Multimedia

    2011-01-01

    The CERN relay race will take place around the Meyrin site on Thursday 19 May starting at 12-15. If possible, please avoid driving on the site during this 20-minute period. If you do meet runners while driving your car, please STOP until they have all passed. Thank you for your cooperation. Details of the course and of how to register your team for the relay race can be found here. Some advice for all runners from the Medical Service can also be found here.   

  14. Relay Selection with Limited and Noisy Feedback

    KAUST Repository

    Eltayeb, Mohammed E.; Elkhalil, Khalil; Mas'ud, Abdullahi Abubakar; Al-Naffouri, Tareq Y.

    2016-01-01

    Relay selection is a simple technique that achieves spatial diversity in cooperative relay networks. Nonetheless, relay selection algorithms generally require error-free channel state information (CSI) from all cooperating relays. Practically, CSI

  15. Opportunistic Relay Selection With Limited Feedback

    KAUST Repository

    Eltayeb, Mohammed E.; Elkhalil, Khalil; Bahrami, Hamid Reza; Al-Naffouri, Tareq Y.

    2015-01-01

    Relay selection is a simple technique that achieves spatial diversity in cooperative relay networks. Generally, relay selection algorithms require channel state information (CSI) feedback from all cooperating relays to make a selection decision

  16. Comprehensive Identification and Spatial Mapping of Habenular Neuronal Types Using Single-Cell RNA-Seq.

    Science.gov (United States)

    Pandey, Shristi; Shekhar, Karthik; Regev, Aviv; Schier, Alexander F

    2018-04-02

    The identification of cell types and marker genes is critical for dissecting neural development and function, but the size and complexity of the brain has hindered the comprehensive discovery of cell types. We combined single-cell RNA-seq (scRNA-seq) with anatomical brain registration to create a comprehensive map of the zebrafish habenula, a conserved forebrain hub involved in pain processing and learning. Single-cell transcriptomes of ∼13,000 habenular cells with 4× cellular coverage identified 18 neuronal types and dozens of marker genes. Registration of marker genes onto a reference atlas created a resource for anatomical and functional studies and enabled the mapping of active neurons onto neuronal types following aversive stimuli. Strikingly, despite brain growth and functional maturation, cell types were retained between the larval and adult habenula. This study provides a gene expression atlas to dissect habenular development and function and offers a general framework for the comprehensive characterization of other brain regions. Copyright © 2018 Elsevier Ltd. All rights reserved.

  17. Sleep Dependent Synaptic Down-Selection (II: Single Neuron Level Benefits for Matching, Selectivity, and Specificity

    Directory of Open Access Journals (Sweden)

    Atif eHashmi

    2013-10-01

    Full Text Available In a companion paper (Nere et al., this volume, we used computer simulations to show that a strategy of activity-dependent, on-line net synaptic potentiation during wake, followed by off-line synaptic depression during sleep, can provide a parsimonious account for several memory benefits of sleep at the systems level, including the consolidation of procedural and declarative memories, gist extraction, and integration of new with old memories. In this paper, we consider the theoretical benefits of this two-step process at the single neuron level and employ the theoretical notion of Matching between brain and environment to measure how this process increases the ability of the neuron to capture regularities in the environment and model them internally. We show that down-selection during sleep is beneficial for increasing or restoring Matching after learning, after integrating new with old memories, and after forgetting irrelevant material. By contrast, alternative schemes, such as additional potentiation in wake, potentiation in sleep, or synaptic renormalization in wake, decrease Matching. We also argue that, by selecting appropriate loops through the brain that tie feedforward synapses with feedback ones in the same dendritic domain, different subsets of neurons can learn to specialize for different contingencies and form sequences of nested perception-action loops. By potentiating such loops when interacting with the environment in wake, and depressing them when disconnected from the environment in sleep, neurons can learn to match the long-term statistical structure of the environment while avoiding spurious modes of functioning and catastrophic interference. Finally, such a two-step process has the additional benefit of desaturating the neuron's ability to learn and of maintaining cellular homeostasis. Thus, sleep-dependent synaptic renormalization offers a parsimonious account for both cellular and systems-level effects of sleep on learning

  18. Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics.

    Directory of Open Access Journals (Sweden)

    Andreas Sagner

    2018-02-01

    Full Text Available During tissue development, multipotent progenitors differentiate into specific cell types in characteristic spatial and temporal patterns. We addressed the mechanism linking progenitor identity and differentiation rate in the neural tube, where motor neuron (MN progenitors differentiate more rapidly than other progenitors. Using single cell transcriptomics, we defined the transcriptional changes associated with the transition of neural progenitors into MNs. Reconstruction of gene expression dynamics from these data indicate a pivotal role for the MN determinant Olig2 just prior to MN differentiation. Olig2 represses expression of the Notch signaling pathway effectors Hes1 and Hes5. Olig2 repression of Hes5 appears to be direct, via a conserved regulatory element within the Hes5 locus that restricts expression from MN progenitors. These findings reveal a tight coupling between the regulatory networks that control patterning and neuronal differentiation and demonstrate how Olig2 acts as the developmental pacemaker coordinating the spatial and temporal pattern of MN generation.

  19. Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.

    Science.gov (United States)

    Mueller, Jerel K; Grigsby, Erinn M; Prevosto, Vincent; Petraglia, Frank W; Rao, Hrishikesh; Deng, Zhi-De; Peterchev, Angel V; Sommer, Marc A; Egner, Tobias; Platt, Michael L; Grill, Warren M

    2014-08-01

    Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating nervous tissue, yet its mechanisms of effect are poorly understood. Here we report new methods for studying the influence of TMS on single neurons in the brain of alert non-human primates. We designed a TMS coil that focuses its effect near the tip of a recording electrode and recording electronics that enable direct acquisition of neuronal signals at the site of peak stimulus strength minimally perturbed by stimulation artifact in awake monkeys (Macaca mulatta). We recorded action potentials within ∼1 ms after 0.4-ms TMS pulses and observed changes in activity that differed significantly for active stimulation as compared with sham stimulation. This methodology is compatible with standard equipment in primate laboratories, allowing easy implementation. Application of these tools will facilitate the refinement of next generation TMS devices, experiments and treatment protocols.

  20. Simultaneous transcranial magnetic stimulation and single neuron recording in alert non-human primates

    Science.gov (United States)

    Mueller, Jerel K.; Grigsby, Erinn M.; Prevosto, Vincent; Petraglia, Frank W.; Rao, Hrishikesh; Deng, Zhi-De; Peterchev, Angel V.; Sommer, Marc A.; Egner, Tobias; Platt, Michael L.; Grill, Warren M.

    2014-01-01

    Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating nervous tissue, yet its mechanisms of effect are poorly understood. Here we report novel methods for studying the influence of TMS on single neurons in the brain of alert non-human primates. We designed a TMS coil that focuses its effect near the tip of a recording electrode and recording electronics that enable direct acquisition of neuronal signals at the site of peak stimulus strength minimally perturbed by stimulation artifact in intact, awake monkeys (Macaca mulatta). We recorded action potentials within ~1 ms after 0.4 ms TMS pulses and observed changes in activity that differed significantly for active stimulation as compared to sham stimulation. The methodology is compatible with standard equipment in primate laboratories, allowing for easy implementation. Application of these new tools will facilitate the refinement of next generation TMS devices, experiments, and treatment protocols. PMID:24974797

  1. Single-cell Transcriptional Analysis Reveals Novel Neuronal Phenotypes and Interaction Networks involved In the Central Circadian Clock

    Directory of Open Access Journals (Sweden)

    James Park

    2016-10-01

    Full Text Available Single-cell heterogeneity confounds efforts to understand how a population of cells organizes into cellular networks that underlie tissue-level function. This complexity is prominent in the mammalian suprachiasmatic nucleus (SCN. Here, individual neurons exhibit a remarkable amount of asynchronous behavior and transcriptional heterogeneity. However, SCN neurons are able to generate precisely coordinated synaptic and molecular outputs that synchronize the body to a common circadian cycle by organizing into cellular networks. To understand this emergent cellular network property, it is important to reconcile single-neuron heterogeneity with network organization. In light of recent studies suggesting that transcriptionally heterogeneous cells organize into distinct cellular phenotypes, we characterized the transcriptional, spatial, and functional organization of 352 SCN neurons from mice experiencing phase-shifts in their circadian cycle. Using the community structure detection method and multivariate analytical techniques, we identified previously undescribed neuronal phenotypes that are likely to participate in regulatory networks with known SCN cell types. Based on the newly discovered neuronal phenotypes, we developed a data-driven neuronal network structure in which multiple cell types interact through known synaptic and paracrine signaling mechanisms. These results provide a basis from which to interpret the functional variability of SCN neurons and describe methodologies towards understanding how a population of heterogeneous single cells organizes into cellular networks that underlie tissue-level function.

  2. CERN Relay Race

    CERN Multimedia

    2004-01-01

    The CERN Relay Race will take place around the Meyrin site on Wednesday 19 May between 12.15 and 12.35. If possible, please avoid driving on the site during this 20 minute period. If you do meet runners in your car, please STOP until they all have passed. Thank you for your understanding

  3. CERN Relay Race

    CERN Multimedia

    2003-01-01

    The CERN Relay Race will take place around the Meyrin site on Wednesday May 21st between 12h15 and 12h35. If possible, please avoid driving on the site during this 20 minute period. If you do meet runners in your car, please STOP until they all have passed. Thank you for your understanding

  4. CERN Relay Race

    CERN Multimedia

    2001-01-01

    The CERN Relay Race will take place around the Meyrin site on Wednesday 23 May between 12:20 and 12:35. If possible, please avoid driving on the site during this 15 minute period. If you do meet runners in your car, please stop until they all have passed. Thank you for your understanding.

  5. CERN Relay Race

    CERN Document Server

    2002-01-01

    The CERN Relay Race will take place around the Meyrin site on Wednesday 22 May between 12h20 and 12h35. If possible, please avoid driving on the site during this 15 minute period. If you do meet runners in your car, please STOP until they all have passed. Thank you for your understanding.

  6. CERN Relay Race

    CERN Multimedia

    2009-01-01

    The CERN relay race, now in its 39th year, is already a well-known tradition, but this year the organizers say the event will have even more of a festival feeling. Just off the starting line of the CERN relay race.For the past few years, spectators and runners at the CERN relay race have been able to enjoy a beer while listening to music from the CERN music and jazz clubs. But this year the organizers are aiming for "even more of a festival atmosphere". As David Nisbet, President of the CERN running club and organizer of the relay race, says: "Work is not just about getting your head down and doing the theory, it’s also about enjoying the company of your colleagues." This year, on top of music from the Santa Luis Band and the Canettes Blues Band, there will be demonstrations from the Aikido and softball clubs, a stretching session by the Fitness club, as well as various stalls and of course, the well-earned beer from AGLUP, the B...

  7. 2005 CERN Relay Race

    CERN Multimedia

    Patrice Loiez

    2005-01-01

    The CERN Relay Race takes place each year in May and sees participants from all areas of the CERN staff. The winners in 2005 were The Shabbys with Los Latinos Volantes in second and Charmilles Technologies a close third. To add a touch of colour and levity, the CERN Jazz Club provided music at the finishing line.

  8. Opportunistic relaying in multipath and slow fading channel: Relay selection and optimal relay selection period

    KAUST Repository

    Sungjoon Park,; Stark, Wayne E.

    2011-01-01

    In this paper we present opportunistic relay communication strategies of decode and forward relaying. The channel that we are considering includes pathloss, shadowing, and fast fading effects. We find a simple outage probability formula

  9. A study of single multiplicative neuron model with nonlinear filters for hourly wind speed prediction

    International Nuclear Information System (INIS)

    Wu, Xuedong; Zhu, Zhiyu; Su, Xunliang; Fan, Shaosheng; Du, Zhaoping; Chang, Yanchao; Zeng, Qingjun

    2015-01-01

    Wind speed prediction is one important methods to guarantee the wind energy integrated into the whole power system smoothly. However, wind power has a non–schedulable nature due to the strong stochastic nature and dynamic uncertainty nature of wind speed. Therefore, wind speed prediction is an indispensable requirement for power system operators. Two new approaches for hourly wind speed prediction are developed in this study by integrating the single multiplicative neuron model and the iterated nonlinear filters for updating the wind speed sequence accurately. In the presented methods, a nonlinear state–space model is first formed based on the single multiplicative neuron model and then the iterated nonlinear filters are employed to perform dynamic state estimation on wind speed sequence with stochastic uncertainty. The suggested approaches are demonstrated using three cases wind speed data and are compared with autoregressive moving average, artificial neural network, kernel ridge regression based residual active learning and single multiplicative neuron model methods. Three types of prediction errors, mean absolute error improvement ratio and running time are employed for different models’ performance comparison. Comparison results from Tables 1–3 indicate that the presented strategies have much better performance for hourly wind speed prediction than other technologies. - Highlights: • Developed two novel hybrid modeling methods for hourly wind speed prediction. • Uncertainty and fluctuations of wind speed can be better explained by novel methods. • Proposed strategies have online adaptive learning ability. • Proposed approaches have shown better performance compared with existed approaches. • Comparison and analysis of two proposed novel models for three cases are provided

  10. Overexpression of cypin alters dendrite morphology, single neuron activity, and network properties via distinct mechanisms

    Science.gov (United States)

    Rodríguez, Ana R.; O'Neill, Kate M.; Swiatkowski, Przemyslaw; Patel, Mihir V.; Firestein, Bonnie L.

    2018-02-01

    Objective. This study investigates the effect that overexpression of cytosolic PSD-95 interactor (cypin), a regulator of synaptic PSD-95 protein localization and a core regulator of dendrite branching, exerts on the electrical activity of rat hippocampal neurons and networks. Approach. We cultured rat hippocampal neurons and used lipid-mediated transfection and lentiviral gene transfer to achieve high levels of cypin or cypin mutant (cypinΔPDZ PSD-95 non-binding) expression cellularly and network-wide, respectively. Main results. Our analysis revealed that although overexpression of cypin and cypinΔPDZ increase dendrite numbers and decrease spine density, cypin and cypinΔPDZ distinctly regulate neuronal activity. At the single cell level, cypin promotes decreases in bursting activity while cypinΔPDZ reduces sEPSC frequency and further decreases bursting compared to cypin. At the network level, by using the Fano factor as a measure of spike count variability, cypin overexpression results in an increase in variability of spike count, and this effect is abolished when cypin cannot bind PSD-95. This variability is also dependent on baseline activity levels and on mean spike rate over time. Finally, our spike sorting data show that overexpression of cypin results in a more complex distribution of spike waveforms and that binding to PSD-95 is essential for this complexity. Significance. Our data suggest that dendrite morphology does not play a major role in cypin action on electrical activity.

  11. Diversity of bilateral synaptic assemblies for binaural computation in midbrain single neurons.

    Science.gov (United States)

    He, Na; Kong, Lingzhi; Lin, Tao; Wang, Shaohui; Liu, Xiuping; Qi, Jiyao; Yan, Jun

    2017-11-01

    Binaural hearing confers many beneficial functions but our understanding of its underlying neural substrates is limited. This study examines the bilateral synaptic assemblies and binaural computation (or integration) in the central nucleus of the inferior colliculus (ICc) of the auditory midbrain, a key convergent center. Using in-vivo whole-cell patch-clamp, the excitatory and inhibitory postsynaptic potentials (EPSPs/IPSPs) of single ICc neurons to contralateral, ipsilateral and bilateral stimulation were recorded. According to the contralateral and ipsilateral EPSP/IPSP, 7 types of bilateral synaptic assemblies were identified. These include EPSP-EPSP (EE), E-IPSP (EI), E-no response (EO), II, IE, IO and complex-mode (CM) neurons. The CM neurons showed frequency- and/or amplitude-dependent EPSPs/IPSPs to contralateral or ipsilateral stimulation. Bilateral stimulation induced EPSPs/IPSPs that could be larger than (facilitation), similar to (ineffectiveness) or smaller than (suppression) those induced by contralateral stimulation. Our findings have allowed our group to characterize novel neural circuitry for binaural computation in the midbrain. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Single-photon emission computed tomographic findings and motor neuron signs in amyotrophic lateral sclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Terao, Shin-ichi; Sobue, Gen; Higashi, Naoki; Takahashi, Masahiko; Suga, Hidemichi; Mitsuma, Terunori [Aichi Medical Univ., Nagakute (Japan)

    1995-03-01

    {sup 123}I-amphetamine-single photon emission computed tomography (SPECT) was performed on 16 patients with amyotrophic lateral sclerosis (ALS) to investigate the correlation between regional cerebral blood flow (rCBF) and upper motor neuron signs. Significant decreased blood flow less than 2 SDs below the mean of controls was observed in the frontal lobe in 4 patients (25%) and in the frontoparietal lobe including the cortical motor area in 4 patients, respectively. The severity of extermity muscular weakness was significantly correlate with decrease in blood flow through the frontal lobe (p<0.05) and through the frontoparietal lobe (p<0.001). A significant correlation was also noted to exist between the severity of bulbar paralysis and decrease in blood flow through the frontoparietal lobe. No correlation, however, was observed between rCBF and severity of spasticity, presence or absence of Babinski`s sign and the duration of illness. Although muscular weakness in the limbs and bulbar paralysis are not pure upper motor neuron signs, the observed reduction in blood flow through the frontal or frontoparietal lobes appears to reflect extensive progression of functional or organic lesions of cortical neurons including the motor area. (author).

  13. Single-photon emission computed tomographic findings and motor neuron signs in amyotrophic lateral sclerosis

    International Nuclear Information System (INIS)

    Terao, Shin-ichi; Sobue, Gen; Higashi, Naoki; Takahashi, Masahiko; Suga, Hidemichi; Mitsuma, Terunori

    1995-01-01

    123 I-amphetamine-single photon emission computed tomography (SPECT) was performed on 16 patients with amyotrophic lateral sclerosis (ALS) to investigate the correlation between regional cerebral blood flow (rCBF) and upper motor neuron signs. Significant decreased blood flow less than 2 SDs below the mean of controls was observed in the frontal lobe in 4 patients (25%) and in the frontoparietal lobe including the cortical motor area in 4 patients, respectively. The severity of extermity muscular weakness was significantly correlate with decrease in blood flow through the frontal lobe (p<0.05) and through the frontoparietal lobe (p<0.001). A significant correlation was also noted to exist between the severity of bulbar paralysis and decrease in blood flow through the frontoparietal lobe. No correlation, however, was observed between rCBF and severity of spasticity, presence or absence of Babinski's sign and the duration of illness. Although muscular weakness in the limbs and bulbar paralysis are not pure upper motor neuron signs, the observed reduction in blood flow through the frontal or frontoparietal lobes appears to reflect extensive progression of functional or organic lesions of cortical neurons including the motor area. (author)

  14. Divisive normalization and neuronal oscillations in a single hierarchical framework of selective visual attention.

    Science.gov (United States)

    Montijn, Jorrit Steven; Klink, P Christaan; van Wezel, Richard J A

    2012-01-01

    Divisive normalization models of covert attention commonly use spike rate modulations as indicators of the effect of top-down attention. In addition, an increasing number of studies have shown that top-down attention increases the synchronization of neuronal oscillations as well, particularly in gamma-band frequencies (25-100 Hz). Although modulations of spike rate and synchronous oscillations are not mutually exclusive as mechanisms of attention, there has thus far been little effort to integrate these concepts into a single framework of attention. Here, we aim to provide such a unified framework by expanding the normalization model of attention with a multi-level hierarchical structure and a time dimension; allowing the simulation of a recently reported backward progression of attentional effects along the visual cortical hierarchy. A simple cascade of normalization models simulating different cortical areas is shown to cause signal degradation and a loss of stimulus discriminability over time. To negate this degradation and ensure stable neuronal stimulus representations, we incorporate a kind of oscillatory phase entrainment into our model that has previously been proposed as the "communication-through-coherence" (CTC) hypothesis. Our analysis shows that divisive normalization and oscillation models can complement each other in a unified account of the neural mechanisms of selective visual attention. The resulting hierarchical normalization and oscillation (HNO) model reproduces several additional spatial and temporal aspects of attentional modulation and predicts a latency effect on neuronal responses as a result of cued attention.

  15. Spectral efficiency enhancement with interference cancellation for wireless relay network

    DEFF Research Database (Denmark)

    Yomo, Hiroyuki; De Carvalho, Elisabeth

    The introduction of relaying into wireless communication system for coverage enhancement can cause severe decrease of spectral efficiency due to the requirement on extra radio resource. In this paper, we propose a method to increase spectral efficiency in such a wireless relay network by employing...... an interference cancellation technique. We focus on a typical scenario of relaying in a cellular system, where a mobile station (MS) requires the help of a relay station (RS) to communicate with the base station (BS). In such a case, interference cancellation can be used to achieve a small reuse distance...... of identical radio resource. We analyze a simple scenario with BS, single RS, and 2 MSs, and show that the proposed method has significant potential to enhance spectral efficiency in wireless relay networks....

  16. From Parkinsonian thalamic activity to restoring thalamic relay using deep brain stimulation: new insights from computational modeling

    Science.gov (United States)

    Meijer, H. G. E.; Krupa, M.; Cagnan, H.; Lourens, M. A. J.; Heida, T.; Martens, H. C. F.; Bour, L. J.; van Gils, S. A.

    2011-10-01

    We present a computational model of a thalamocortical relay neuron for exploring basal ganglia thalamocortical loop behavior in relation to Parkinson's disease and deep brain stimulation (DBS). Previous microelectrode, single-unit recording studies demonstrated that oscillatory interaction within and between basal ganglia nuclei is very often accompanied by synchronization at Parkinsonian rest tremor frequencies (3-10 Hz). These oscillations have a profound influence on thalamic projections and impair the thalamic relaying of cortical input by generating rebound action potentials. Our model describes convergent inhibitory input received from basal ganglia by the thalamocortical cells based on characteristics of normal activity, and/or low-frequency oscillations (activity associated with Parkinson's disease). In addition to simulated input, we also used microelectrode recordings as inputs for the model. In the resting state, and without additional sensorimotor input, pathological rebound activity is generated for even mild Parkinsonian input. We have found a specific stimulation window of amplitudes and frequencies for periodic input, which corresponds to high-frequency DBS, and which also suppresses rebound activity for mild and even more prominent Parkinsonian input. When low-frequency pathological rebound activity disables the thalamocortical cell's ability to relay excitatory cortical input, a stimulation signal with parameter settings corresponding to our stimulation window can restore the thalamocortical cell's relay functionality.

  17. A single GABAergic neuron mediates feedback of odor-evoked signals in the mushroom body of larval Drosophila

    Directory of Open Access Journals (Sweden)

    Liria Monica Masuda-Nakagawa

    2014-04-01

    Full Text Available Inhibition has a central role in defining the selectivity of the responses of higher order neurons to sensory stimuli. However, the circuit mechanisms of regulation of these responses by inhibitory neurons are still unclear. In Drosophila, the mushroom bodies (MBs are necessary for olfactory memory, and by implication for the selectivity of learned responses to specific odors. To understand the circuitry of inhibition in the calyx (the input dendritic region of the MBs, and its relationship with MB excitatory activity, we used the simple anatomy of the Drosophila larval olfactory system to identify any inhibitory inputs that could contribute to the selectivity of MB odor responses. We found that a single neuron accounts for all detectable GABA innervation in the calyx of the MBs, and that this neuron has presynaptic terminals in the calyx and postsynaptic branches in the MB lobes (output axonal area. We call this neuron the larval anterior paired lateral (APL neuron, because of its similarity to the previously described adult APL neuron. Reconstitution of GFP partners (GRASP suggests that the larval APL makes extensive contacts with the MB intrinsic neurons, Kenyon Cells (KCs, but few contacts with incoming projection neurons. Using calcium imaging of neuronal activity in live larvae, we show that the larval APL responds to odors, in a mannner that requires output from KCs. Our data suggest that the larval APL is the sole GABAergic neuron that innervates the MB input region and carries inhibitory feedback from the MB output region, consistent with a role in modulating the olfactory selectivity of MB neurons.

  18. A novel single neuron perceptron with universal approximation and XOR computation properties.

    Science.gov (United States)

    Lotfi, Ehsan; Akbarzadeh-T, M-R

    2014-01-01

    We propose a biologically motivated brain-inspired single neuron perceptron (SNP) with universal approximation and XOR computation properties. This computational model extends the input pattern and is based on the excitatory and inhibitory learning rules inspired from neural connections in the human brain's nervous system. The resulting architecture of SNP can be trained by supervised excitatory and inhibitory online learning rules. The main features of proposed single layer perceptron are universal approximation property and low computational complexity. The method is tested on 6 UCI (University of California, Irvine) pattern recognition and classification datasets. Various comparisons with multilayer perceptron (MLP) with gradient decent backpropagation (GDBP) learning algorithm indicate the superiority of the approach in terms of higher accuracy, lower time, and spatial complexity, as well as faster training. Hence, we believe the proposed approach can be generally applicable to various problems such as in pattern recognition and classification.

  19. Orientation selectivity in inhibition-dominated networks of spiking neurons: effect of single neuron properties and network dynamics.

    Science.gov (United States)

    Sadeh, Sadra; Rotter, Stefan

    2015-01-01

    The neuronal mechanisms underlying the emergence of orientation selectivity in the primary visual cortex of mammals are still elusive. In rodents, visual neurons show highly selective responses to oriented stimuli, but neighboring neurons do not necessarily have similar preferences. Instead of a smooth map, one observes a salt-and-pepper organization of orientation selectivity. Modeling studies have recently confirmed that balanced random networks are indeed capable of amplifying weakly tuned inputs and generating highly selective output responses, even in absence of feature-selective recurrent connectivity. Here we seek to elucidate the neuronal mechanisms underlying this phenomenon by resorting to networks of integrate-and-fire neurons, which are amenable to analytic treatment. Specifically, in networks of perfect integrate-and-fire neurons, we observe that highly selective and contrast invariant output responses emerge, very similar to networks of leaky integrate-and-fire neurons. We then demonstrate that a theory based on mean firing rates and the detailed network topology predicts the output responses, and explains the mechanisms underlying the suppression of the common-mode, amplification of modulation, and contrast invariance. Increasing inhibition dominance in our networks makes the rectifying nonlinearity more prominent, which in turn adds some distortions to the otherwise essentially linear prediction. An extension of the linear theory can account for all the distortions, enabling us to compute the exact shape of every individual tuning curve in our networks. We show that this simple form of nonlinearity adds two important properties to orientation selectivity in the network, namely sharpening of tuning curves and extra suppression of the modulation. The theory can be further extended to account for the nonlinearity of the leaky model by replacing the rectifier by the appropriate smooth input-output transfer function. These results are robust and do not

  20. Orientation selectivity in inhibition-dominated networks of spiking neurons: effect of single neuron properties and network dynamics.

    Directory of Open Access Journals (Sweden)

    Sadra Sadeh

    2015-01-01

    Full Text Available The neuronal mechanisms underlying the emergence of orientation selectivity in the primary visual cortex of mammals are still elusive. In rodents, visual neurons show highly selective responses to oriented stimuli, but neighboring neurons do not necessarily have similar preferences. Instead of a smooth map, one observes a salt-and-pepper organization of orientation selectivity. Modeling studies have recently confirmed that balanced random networks are indeed capable of amplifying weakly tuned inputs and generating highly selective output responses, even in absence of feature-selective recurrent connectivity. Here we seek to elucidate the neuronal mechanisms underlying this phenomenon by resorting to networks of integrate-and-fire neurons, which are amenable to analytic treatment. Specifically, in networks of perfect integrate-and-fire neurons, we observe that highly selective and contrast invariant output responses emerge, very similar to networks of leaky integrate-and-fire neurons. We then demonstrate that a theory based on mean firing rates and the detailed network topology predicts the output responses, and explains the mechanisms underlying the suppression of the common-mode, amplification of modulation, and contrast invariance. Increasing inhibition dominance in our networks makes the rectifying nonlinearity more prominent, which in turn adds some distortions to the otherwise essentially linear prediction. An extension of the linear theory can account for all the distortions, enabling us to compute the exact shape of every individual tuning curve in our networks. We show that this simple form of nonlinearity adds two important properties to orientation selectivity in the network, namely sharpening of tuning curves and extra suppression of the modulation. The theory can be further extended to account for the nonlinearity of the leaky model by replacing the rectifier by the appropriate smooth input-output transfer function. These results are

  1. Elucidating distinct ion channel populations on the surface of hippocampal neurons via single-particle tracking recurrence analysis

    Science.gov (United States)

    Sikora, Grzegorz; Wyłomańska, Agnieszka; Gajda, Janusz; Solé, Laura; Akin, Elizabeth J.; Tamkun, Michael M.; Krapf, Diego

    2017-12-01

    Protein and lipid nanodomains are prevalent on the surface of mammalian cells. In particular, it has been recently recognized that ion channels assemble into surface nanoclusters in the soma of cultured neurons. However, the interactions of these molecules with surface nanodomains display a considerable degree of heterogeneity. Here, we investigate this heterogeneity and develop statistical tools based on the recurrence of individual trajectories to identify subpopulations within ion channels in the neuronal surface. We specifically study the dynamics of the K+ channel Kv1.4 and the Na+ channel Nav1.6 on the surface of cultured hippocampal neurons at the single-molecule level. We find that both these molecules are expressed in two different forms with distinct kinetics with regards to surface interactions, emphasizing the complex proteomic landscape of the neuronal surface. Further, the tools presented in this work provide new methods for the analysis of membrane nanodomains, transient confinement, and identification of populations within single-particle trajectories.

  2. A single hidden layer feedforward network with only one neuron in the hidden layer can approximate any univariate function

    OpenAIRE

    Guliyev , Namig; Ismailov , Vugar

    2016-01-01

    The possibility of approximating a continuous function on a compact subset of the real line by a feedforward single hidden layer neural network with a sigmoidal activation function has been studied in many papers. Such networks can approximate an arbitrary continuous function provided that an unlimited number of neurons in a hidden layer is permitted. In this paper, we consider constructive approximation on any finite interval of $\\mathbb{R}$ by neural networks with only one neuron in the hid...

  3. Relay Selection for Cooperative Relaying in Wireless Energy Harvesting Networks

    Science.gov (United States)

    Zhu, Kaiyan; Wang, Fei; Li, Songsong; Jiang, Fengjiao; Cao, Lijie

    2018-01-01

    Energy harvesting from the surroundings is a promising solution to provide energy supply and extend the life of wireless sensor networks. Recently, energy harvesting has been shown as an attractive solution to prolong the operation of cooperative networks. In this paper, we propose a relay selection scheme to optimize the amplify-and-forward (AF) cooperative transmission in wireless energy harvesting cooperative networks. The harvesting energy and channel conditions are considered to select the optimal relay as cooperative relay to minimize the outage probability of the system. Simulation results show that our proposed relay selection scheme achieves better outage performance than other strategies.

  4. Opportunistic Relay Selection in Multicast Relay Networks using Compressive Sensing

    KAUST Repository

    Elkhalil, Khalil

    2014-12-01

    Relay selection is a simple technique that achieves spatial diversity in cooperative relay networks. However, for relay selection algorithms to make a selection decision, channel state information (CSI) from all cooperating relays is usually required at a central node. This requirement poses two important challenges. Firstly, CSI acquisition generates a great deal of feedback overhead (air-time) that could result in significant transmission delays. Secondly, the fed back channel information is usually corrupted by additive noise. This could lead to transmission outages if the central node selects the set of cooperating relays based on inaccurate feedback information. In this paper, we introduce a limited feedback relay selection algorithm for a multicast relay network. The proposed algorithm exploits the theory of compressive sensing to first obtain the identity of the “strong” relays with limited feedback. Following that, the CSI of the selected relays is estimated using linear minimum mean square error estimation. To minimize the effect of noise on the fed back CSI, we introduce a back-off strategy that optimally backs-off on the noisy estimated CSI. For a fixed group size, we provide closed form expressions for the scaling law of the maximum equivalent SNR for both Decode and Forward (DF) and Amplify and Forward (AF) cases. Numerical results show that the proposed algorithm drastically reduces the feedback air-time and achieves a rate close to that obtained by selection algorithms with dedicated error-free feedback channels.

  5. Plasticity of marrow mesenchymal stem cells from human first-trimester fetus: from single-cell clone to neuronal differentiation.

    Science.gov (United States)

    Zhang, Yihua; Shen, Wenzheng; Sun, Bingjie; Lv, Changrong; Dou, Zhongying

    2011-02-01

    Recent results have shown that bone marrow mesenchymal stem cells (BMSCs) from human first-trimester abortus (hfBMSCs) are closer to embryonic stem cells and perform greater telomerase activity and faster propagation than mid- and late-prophase fetal and adult BMSCs. However, no research has been done on the plasticity of hfBMSCs into neuronal cells using single-cell cloned strains without cell contamination. In this study, we isolated five single cells from hfBMSCs and obtained five single-cell cloned strains, and investigated their biological property and neuronal differentiation potential. We found that four of the five strains showed similar expression profile of surface antigen markers to hfBMSCs, and most of them differentiated into neuron-like cells expressing Nestin, Pax6, Sox1, β-III Tubulin, NF-L, and NSE under induction. One strain showed different expression profile of surface antigen markers from the four strains and hfBMSCs, and did not differentiate toward neuronal cells. We demonstrated for the first time that some of single-cell cloned strains from hfBMSCs can differentiate into nerve tissue-like cell clusters under induction in vitro, and that the plasticity of each single-cell cloned strain into neuronal cells is different.

  6. Divisive normalization and neuronal oscillations in a single hierarchical framework of selective visual attention

    Directory of Open Access Journals (Sweden)

    Jorrit Steven Montijn

    2012-05-01

    Full Text Available In divisive normalization models of covert attention, spike rate modulations are commonly used as indicators of the effect of top-down attention. In addition, an increasing number of studies have shown that top-down attention increases the synchronization of neuronal oscillations as well, particularly those in gamma-band frequencies (25 to 100 Hz. Although modulations of spike rate and synchronous oscillations are not mutually exclusive as mechanisms of attention, there has thus far been little effort to integrate these concepts into a single framework of attention. Here, we aim to provide such a unified framework by expanding the normalization model of attention with a time dimension; allowing the simulation of a recently reported backward progression of attentional effects along the visual cortical hierarchy. A simple hierarchical cascade of normalization models simulating different cortical areas however leads to signal degradation and a loss of discriminability over time. To negate this degradation and ensure stable neuronal stimulus representations, we incorporate oscillatory phase entrainment into our model, a mechanism previously proposed as the communication-through-coherence (CTC hypothesis. Our analysis shows that divisive normalization and oscillation models can complement each other in a unified account of the neural mechanisms of selective visual attention. The resulting hierarchical normalization and oscillation (HNO model reproduces several additional spatial and temporal aspects of attentional modulation.

  7. Synthesis of relay control systems for nuclear reactors

    International Nuclear Information System (INIS)

    Postnikov, N.S.

    1996-01-01

    The problem on stabilizing an oscillatory-unstable reactor by a single-link relay system, the characteristics whereof have a dead zone and hysteresis loop, is considered. The methodology of synthesis of feedback law, providing for stochastic steady-state mode of reactor operation with the minimum frequency of control impact introduction is proposed. This methodology is applicable to general-type relay systems with arbitrary oscillatory-unstable objects. 6 refs., 5 figs

  8. Alternate MIMO relaying with three AF relays using interference alignment

    KAUST Repository

    Park, Kihong; Alouini, Mohamed-Slim

    2012-01-01

    In this paper, we study a two-hop half-duplex relaying network with one source, one destination, and three amplify-and-forward (AF) relays equipped with M antennas each. We consider alternate transmission to compensate for the inherent loss

  9. Co-release of glutamate and GABA from single vesicles in GABAergic neurons exogenously expressing VGLUT3

    Directory of Open Access Journals (Sweden)

    Johannes eZimmermann

    2015-09-01

    Full Text Available The identity of the vesicle neurotransmitter transporter expressed by a neuron largely corresponds with the primary neurotransmitter that cell releases. However, the vesicular glutamate transporter subtype 3 (VGLUT3 is mainly expressed in non-glutamatergic neurons, including cholinergic, serotonergic, or GABAergic neurons. Though a functional role for glutamate release from these non-glutamatergic neurons has been demonstrated, the interplay between VGLUT3 and the neuron’s characteristic neurotransmitter transporter, particularly in the case of GABAergic neurons, at the synaptic and vesicular level is less clear. In this study, we explore how exogenous expression of VGLUT3 in striatal GABAergic neurons affects the packaging and release of glutamate and GABA in synaptic vesicles. We found that VGLUT3 expression in isolated, autaptic GABAergic neurons leads to action potential evoked release of glutamate. Under these conditions, glutamate and GABA could be packaged together in single vesicles release either spontaneously or asynchronously. However, the presence of glutamate in GABAergic vesicles did not affect uptake of GABA itself, suggesting a lack of synergy in vesicle filling for these transmitters. Finally, we found postsynaptic detection of glutamate released from GABAergic terminals difficult when bona fide glutamatergic synapses were present, suggesting that co-released glutamate cannot induce postsynaptic glutamate receptor clustering.

  10. On the capacity of multiple cognitive links through common relay under spectrum-sharing constraints

    KAUST Repository

    Yang, Yuli

    2011-06-01

    In this paper, we consider an underlay cognitive relaying network consisting of multiple secondary users and introduce a cooperative transmission protocol using a common relay to help with the communications between all secondary source-destination pairs for higher throughput and lower realization complexity. A whole relay-assisted transmission procedure is composed of multiple access phase and broadcast phase, where the relay is equipped with multiple antennas, and the secondary sources and destinations are single-antenna nodes. Considering the spectrum-sharing constraints on the secondary sources and the relay, we analyze the capacity behaviors of the underlay cognitive relaying network under study. The corresponding numerical results provide a convenient tool for the presented network design and substantiate a distinguishing feature of introduced design in that multiple secondary users\\' communications do not rely on multiple relays, hence allowing for a more efficient use of the radio resources. © 2011 IEEE.

  11. Joint source and relay optimization for interference MIMO relay networks

    Science.gov (United States)

    Khandaker, Muhammad R. A.; Wong, Kai-Kit

    2017-12-01

    This paper considers multiple-input multiple-output (MIMO) relay communication in multi-cellular (interference) systems in which MIMO source-destination pairs communicate simultaneously. It is assumed that due to severe attenuation and/or shadowing effects, communication links can be established only with the aid of a relay node. The aim is to minimize the maximal mean-square-error (MSE) among all the receiving nodes under constrained source and relay transmit powers. Both one- and two-way amplify-and-forward (AF) relaying mechanisms are considered. Since the exactly optimal solution for this practically appealing problem is intractable, we first propose optimizing the source, relay, and receiver matrices in an alternating fashion. Then we contrive a simplified semidefinite programming (SDP) solution based on the error covariance matrix decomposition technique, avoiding the high complexity of the iterative process. Numerical results reveal the effectiveness of the proposed schemes.

  12. Outage performance of opportunistic two-way amplify-and-forward relaying with outdated channel state information

    KAUST Repository

    Hwang, Kyusung; Ju, Minchul; Alouini, Mohamed-Slim

    2013-01-01

    In this paper, we study the outage performance of an amplify-and-forward (AF)-based two-way relaying (TWR) system with multiple relays where a single relay selection is performed based on outdated channel state information (CSI). Specifically, we

  13. Internally generated preactivation of single neurons in human medial frontal cortex predicts volition

    OpenAIRE

    Fried, Itzhak; Mukamel, Roy; Kreiman, Gabriel

    2011-01-01

    Understanding how self-initiated behavior is encoded by neuronal circuits in the human brain remains elusive. We recorded the activity of 1019 neurons while twelve subjects performed self-initiated finger movement. We report progressive neuronal recruitment over ∼1500 ms before subjects report making the decision to move. We observed progressive increase or decrease in neuronal firing rate, particularly in the supplementary motor area (SMA), as the reported time of decision was approached. A ...

  14. Single-Cell Imaging of Bioenergetic Responses to Neuronal Excitotoxicity and Oxygen and Glucose Deprivation

    OpenAIRE

    Connolly, Niamh M; Düssmann, Heiko; Anilkumar, Ujval; Huber, Heinrich J; Prehn, Jochen HM

    2014-01-01

    Excitotoxicity is a condition occurring during cerebral ischemia, seizures, and chronic neurodegeneration. It is characterized by overactivation of glutamate receptors, leading to excessive Ca2+/Na+ influx into neurons, energetic stress, and subsequent neuronal injury.We and others have previously investigated neuronal populations to study how bioenergetic parameters determine neuronal injury; however, such experiments are often confounded by population-based heterogeneity and the contributio...

  15. CERN Relay Race 2018

    CERN Document Server

    CERN Running club

    2018-01-01

    The CERN running club, in collaboration with the Staff Association, is happy to announce the 2018 relay race edition. It will take place on Thursday, May 24th and will consist as every year in a round trip of the CERN Meyrin site in teams of 6 members. It is a fun event, and you do not have to run fast to enjoy it. Registrations will be open from May 1st to May 22nd on the running club web site. All information concerning the race and the registration are available there too: http://runningclub.web.cern.ch/content/cern-relay-race. A video of the previous edition is also available here : http://cern.ch/go/Nk7C. As every year, there will be animations starting at noon on the lawn in front of restaurant 1, and information stands for many CERN associations and clubs will be available. The running club partners will also be participate in the event, namely Berthie Sport, Interfon and Uniqa.

  16. 47th Relay Race!

    CERN Document Server

    Staff Association

    2017-01-01

    On Thursday June 1st at 12.15, Fabiola Gianotti, our Director-General, will fire the starting shot for the 47th Relay Race. This Race is above all a festive CERN event, open for runners and walkers, as well as the people cheering them on throughout the race, and those who wish to participate in the various activities organised between 11.30 and 14.30 out on the lawn in front of Restaurant 1. In order to make this sports event accessible for everyone, our Director-General will allow for flexible lunch hours on the day, applicable for all the members of personnel. An alert for the closure of roads will be send out on the day of the event. The Staff Association and the CERN Running Club thank you in advance for your participation and your continued support throughout the years. This year the CERN Running Club has announced the participation of locally and internationally renowned runners, no less! A bit over a week from the Relay Race of 1st June, the number of teams is going up nicely (already almost 40). Am...

  17. CERN Relay Race

    CERN Multimedia

    Running Club

    2010-01-01

    This year’s CERN Relay Race will take place around the Meyrin site on Thursday 20th May at 12h00. This annual event is for teams of 6 runners covering distances of 1000m, 800m, 800m, 500m, 500m and 300m respectively. Teams may be entered in the Seniors, Veterans, Ladies, Mixed or Open categories. The registration fee is 10 CHF per runner, and each runner receives a souvenir prize. As usual, there will be a programme of entertainments from 12h in the arrival area, in front of the Restaurant no. 1. Drinks, food, CERN club information and music will be available for the pleasure of both runners and spectators. The race starts at 12h15, with results and prize giving at 13:15.   For details of the race, and of how to sign up a team, please visit: https://espace.cern.ch/Running-Club/CERN-Relay The event is organised by the CERN Running Club with the support of the CERN Staff Association.  

  18. MIMO Four-Way Relaying

    DEFF Research Database (Denmark)

    Liu, Huaping; Sun, Fan; De Carvalho, Elisabeth

    2013-01-01

    Two-way relaying in wireless systems has initiated a large research effort during the past few years. Nevertheless, it represents only a specific traffic pattern and it is of interest to investigate other traffic patterns where such a simultaneous processing of information flows can bring...... performance advantage. In this paper we consider a \\emph{four-way relaying} multiple-input multiple-output (MIMO) scenario, where each of the two Mobile Stations (MSs) has a two-way connection to the same Base Station (BS), while each connection is through a dedicated Relay Station (RS). The RSs are placed...... the sum-rate of the new scheme for Decode-and-Forward (DF) operational model for the RS. We compare the performance with state-of-the-art reference schemes, based on two-way relaying with DF. The results indicate that the sum-rate of the two-phase four-way relaying scheme largely outperforms the four...

  19. Selection combining for noncoherent decode-and-forward relay networks

    Directory of Open Access Journals (Sweden)

    Nguyen Ha

    2011-01-01

    Full Text Available Abstract This paper studies a new decode-and-forward relaying scheme for a cooperative wireless network composed of one source, K relays, and one destination and with binary frequency-shift keying modulation. A single threshold is employed to select retransmitting relays as follows: a relay retransmits to the destination if its decision variable is larger than the threshold; otherwise, it remains silent. The destination then performs selection combining for the detection of transmitted information. The average end-to-end bit-error-rate (BER is analytically determined in a closed-form expression. Based on the derived BER, the problem of choosing an optimal threshold or jointly optimal threshold and power allocation to minimize the end-to-end BER is also investigated. Both analytical and simulation results reveal that the obtained optimal threshold scheme or jointly optimal threshold and power-allocation scheme can significantly improve the BER performance compared to a previously proposed scheme.

  20. CERN Relay Race

    CERN Document Server

    2005-01-01

    The CERN Relay Race will take place around the Meyrin site on Wednesday 18 May between 12.15 and 12.35. This year, weather permitting, there will be some new attractions in the start/finish area on the field behind the Main Building. You will be able to: listen to music played by the CERN Jazz Club; buy drinks at the bar organised by the CERN Running Club; buy lunch served directly on the terrace by the restaurant Novae. ATTENTION: concerning traffic, the recommendations are the same as always: If possible, please avoid driving on the site during this 20 minute period. If you do meet runners in your car, please STOP until they all have passed. Thank you for your understanding.

  1. Voz sobre frame relay

    OpenAIRE

    D´Elia, Gabriel Anibal

    2000-01-01

    Esta tesis trata el tema de VOFR, desde la digitalización de la voz hasta su transmisión a través de dicha red, así también como la comparación con otros medios de transporte como VOIP. Dada las características del protocolo frame relay y su disponibilidad se eligió como el medio más apropiado para la transmisión de voz y datos en forma integrada sobre una misma red. El trabajo comienza con una breve explicación de la voz, su digitalización y forma actual de transmisión a través de una red di...

  2. Task-dependent changes in cross-level coupling between single neurons and oscillatory activity in multiscale networks.

    Directory of Open Access Journals (Sweden)

    Ryan T Canolty

    Full Text Available Understanding the principles governing the dynamic coordination of functional brain networks remains an important unmet goal within neuroscience. How do distributed ensembles of neurons transiently coordinate their activity across a variety of spatial and temporal scales? While a complete mechanistic account of this process remains elusive, evidence suggests that neuronal oscillations may play a key role in this process, with different rhythms influencing both local computation and long-range communication. To investigate this question, we recorded multiple single unit and local field potential (LFP activity from microelectrode arrays implanted bilaterally in macaque motor areas. Monkeys performed a delayed center-out reach task either manually using their natural arm (Manual Control, MC or under direct neural control through a brain-machine interface (Brain Control, BC. In accord with prior work, we found that the spiking activity of individual neurons is coupled to multiple aspects of the ongoing motor beta rhythm (10-45 Hz during both MC and BC, with neurons exhibiting a diversity of coupling preferences. However, here we show that for identified single neurons, this beta-to-rate mapping can change in a reversible and task-dependent way. For example, as beta power increases, a given neuron may increase spiking during MC but decrease spiking during BC, or exhibit a reversible shift in the preferred phase of firing. The within-task stability of coupling, combined with the reversible cross-task changes in coupling, suggest that task-dependent changes in the beta-to-rate mapping play a role in the transient functional reorganization of neural ensembles. We characterize the range of task-dependent changes in the mapping from beta amplitude, phase, and inter-hemispheric phase differences to the spike rates of an ensemble of simultaneously-recorded neurons, and discuss the potential implications that dynamic remapping from oscillatory activity to

  3. Temporal-pattern recognition by single neurons in a sensory pathway devoted to social communication behavior.

    Science.gov (United States)

    Carlson, Bruce A

    2009-07-29

    Sensory systems often encode stimulus information into the temporal pattern of action potential activity. However, little is known about how the information contained within these patterns is extracted by postsynaptic neurons. Similar to temporal coding by sensory neurons, social information in mormyrid fish is encoded into the temporal patterning of an electric organ discharge. In the current study, sensitivity to temporal patterns of electrosensory stimuli was found to arise within the midbrain posterior exterolateral nucleus (ELp). Whole-cell patch recordings from ELp neurons in vivo revealed three patterns of interpulse interval (IPI) tuning: low-pass neurons tuned to long intervals, high-pass neurons tuned to short intervals, and bandpass neurons tuned to intermediate intervals. Many neurons within each class also responded preferentially to either increasing or decreasing IPIs. Playback of electric signaling patterns recorded from freely behaving fish revealed that the IPI and direction tuning of ELp neurons resulted in selective responses to particular social communication displays characterized by distinct IPI patterns. The postsynaptic potential responses of many neurons indicated a combination of excitatory and inhibitory synaptic input, and the IPI tuning of ELp neurons was directly related to rate-dependent changes in the direction and amplitude of postsynaptic potentials. These results suggest that differences in the dynamics of short-term synaptic plasticity in excitatory and inhibitory pathways may tune central sensory neurons to particular temporal patterns of presynaptic activity. This may represent a general mechanism for the processing of behaviorally relevant stimulus information encoded into temporal patterns of activity by sensory neurons.

  4. Single-neuron correlates of subjective vision in the human medial temporal lobe

    OpenAIRE

    Kreiman, Gabriel; Fried, Itzhak; Koch, Christof

    2002-01-01

    Visual information from the environment is transformed into perceptual sensations through several stages of neuronal processing. Flash suppression constitutes a striking example in which the same retinal input can give rise to two different conscious visual percepts. We directly recorded the responses of individual neurons during flash suppression in the human amygdala, entorhinal cortex, hippocampus, and parahippocampal gyrus, allowing us to explore the neuronal responses in untrained subjec...

  5. Relay testing at Brookhaven National Laboratory

    International Nuclear Information System (INIS)

    Bandyopadhyay, K.; Hofmayer, C.

    1989-01-01

    Brookhaven National Laboratory (BNL) is conducting a seismic test program on relays. The purpose of the test program is to investigate the influence of various designs, electrical and vibration parameters on the seismic capacity levels. The first series of testing has been completed and performed at Wyle Laboratories. The major part of the test program consisted of single axis, single frequency sine dwell tests. Random multiaxis, multifrequency tests were also performed. Highlights of the test results as well as a description of the testing methods are presented in this paper. 10 figs

  6. Coordinate control of integral reactor based on single neuron PID controller

    International Nuclear Information System (INIS)

    Liu Yan; Xia Hong

    2014-01-01

    As one of the main type of reactors in the future, the development of the integral reactor has attracted worldwide attention. On the basis of understanding the background of the integral reactor, the author will be familiar with and master the power control of reactor and the feedwater flow control of steam generator, and the speed control of turbine (turbine speed control is associated with the turbine load control). According to the expectative program 'reactor power following turbine load' of the reactor, it will make coordinate control of the three and come to a overall control scheme. The author will use the supervisory learning algorithm of Hebb for single neuron PID controller with self-adaptation to study the coordinate control of integral reactor. Compared with conventional PI or PID controller, to a certain extent, it solves the problems that traditional PID controller is not easy to tune real-time parameters and lack of effective control for a number of complex processes and slow-varying parameter systems. It improves the security, reliability, stability and flexibility of control process and achieves effective control of the system. (authors)

  7. Single K ATP channel opening in response to action potential firing in mouse dentate granule neurons.

    Science.gov (United States)

    Tanner, Geoffrey R; Lutas, Andrew; Martínez-François, Juan Ramón; Yellen, Gary

    2011-06-08

    ATP-sensitive potassium channels (K(ATP) channels) are important sensors of cellular metabolic state that link metabolism and excitability in neuroendocrine cells, but their role in nonglucosensing central neurons is less well understood. To examine a possible role for K(ATP) channels in modulating excitability in hippocampal circuits, we recorded the activity of single K(ATP) channels in cell-attached patches of granule cells in the mouse dentate gyrus during bursts of action potentials generated by antidromic stimulation of the mossy fibers. Ensemble averages of the open probability (p(open)) of single K(ATP) channels over repeated trials of stimulated spike activity showed a transient increase in p(open) in response to action potential firing. Channel currents were identified as K(ATP) channels through blockade with glibenclamide and by comparison with recordings from Kir6.2 knock-out mice. The transient elevation in K(ATP) p(open) may arise from submembrane ATP depletion by the Na(+)-K(+) ATPase, as the pump blocker strophanthidin reduced the magnitude of the elevation. Both the steady-state and stimulus-elevated p(open) of the recorded channels were higher in the presence of the ketone body R-β-hydroxybutyrate, consistent with earlier findings that ketone bodies can affect K(ATP) activity. Using perforated-patch recording, we also found that K(ATP) channels contribute to the slow afterhyperpolarization following an evoked burst of action potentials. We propose that activity-dependent opening of K(ATP) channels may help granule cells act as a seizure gate in the hippocampus and that ketone-body-mediated augmentation of the activity-dependent opening could in part explain the effect of the ketogenic diet in reducing epileptic seizures.

  8. Spike and burst coding in thalamocortical relay cells.

    Directory of Open Access Journals (Sweden)

    Fleur Zeldenrust

    2018-02-01

    Full Text Available Mammalian thalamocortical relay (TCR neurons switch their firing activity between a tonic spiking and a bursting regime. In a combined experimental and computational study, we investigated the features in the input signal that single spikes and bursts in the output spike train represent and how this code is influenced by the membrane voltage state of the neuron. Identical frozen Gaussian noise current traces were injected into TCR neurons in rat brain slices as well as in a validated three-compartment TCR model cell. The resulting membrane voltage traces and spike trains were analyzed by calculating the coherence and impedance. Reverse correlation techniques gave the Event-Triggered Average (ETA and the Event-Triggered Covariance (ETC. This demonstrated that the feature selectivity started relatively long before the events (up to 300 ms and showed a clear distinction between spikes (selective for fluctuations and bursts (selective for integration. The model cell was fine-tuned to mimic the frozen noise initiated spike and burst responses to within experimental accuracy, especially for the mixed mode regimes. The information content carried by the various types of events in the signal as well as by the whole signal was calculated. Bursts phase-lock to and transfer information at lower frequencies than single spikes. On depolarization the neuron transits smoothly from the predominantly bursting regime to a spiking regime, in which it is more sensitive to high-frequency fluctuations. The model was then used to elucidate properties that could not be assessed experimentally, in particular the role of two important subthreshold voltage-dependent currents: the low threshold activated calcium current (IT and the cyclic nucleotide modulated h current (Ih. The ETAs of those currents and their underlying activation/inactivation states not only explained the state dependence of the firing regime but also the long-lasting concerted dynamic action of the two

  9. Control circuit for transformer relay

    International Nuclear Information System (INIS)

    Wyatt, G.A.

    1984-01-01

    A control circuit for a transformer relay which will automatically momentarily control the transformer relay to a selected state upon energization of the control circuit. The control circuit has an energy storage element and a current director coupled in series and adapted to be coupled with the secondary winding of the transformer relay. A device for discharge is coupled across the energy storage element. The energy storage element and current director will momentarily allow a unidirectional flow of current in the secondary winding of the transformer relay upon application of energy to the control circuit. When energy is not applied to the control circuit the device for discharge will allow the energy storage element to discharge and be available for another operation of the control circuit

  10. Not a single but multiple populations of GABAergic neurons control sleep.

    Science.gov (United States)

    Luppi, Pierre-Hervé; Peyron, Christelle; Fort, Patrice

    2017-04-01

    The role of gamma-amino butyric acid (GABA) in sleep induction and maintenance is well accepted since most insomnia treatments target GABAa receptors. However, the population(s) of GABAergic neurons involved in the beneficial effect of GABA on sleep remains to be identified. This is not an easy task since GABAergic neurons are widely distributed in all brain structures. A recently growing number of populations of GABAergic neurons have been involved in sleep control. We first review here possible candidates for inducing non-rapid eye movement (NREM) sleep including the GABAergic neurons of the ventrolateral preoptic area, the parafacial zone in the brainstem, the nucleus accumbens and the cortex. We also discuss the role of several populations of GABAergic neurons in rapid eye movement (REM) sleep control. Indeed, it is well accepted that muscle atonia occurring during REM sleep is due to a GABA/glycinergic hyperpolarization of motoneurons. Recent evidence strongly suggests that these neurons are located in the ventral medullary reticular formation. It has also recently been shown that neurons containing the neuropeptide melanin concentrating hormone and GABA located in the lateral hypothalamic area control REM sleep expression. Finally, a population of REM-off GABAergic neurons located in the ventrolateral periaqueductal gray has been shown to gate REM sleep by inhibiting glutamatergic neurons located in the sublaterodorsal tegmental nucleus. In summary, recent data clearly indicate that multiple populations of GABAergic neurons located throughout the brain from the cortex to the medulla oblongata control NREM and REM sleep. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. The 2009 Relay Race

    CERN Multimedia

    2009-01-01

    The 2009 CERN Relay Race was as popular as ever, with a record number of 88 teams competing. var flash_video_player=get_video_player_path(); insert_player_for_external('Video/Public/Movies/2009/CERN-MOVIE-2009-048/CERN-MOVIE-2009-048-0753-kbps-480x360-25-fps-audio-64-kbps-44-kHz-stereo', 'mms://mediastream.cern.ch/MediaArchive/Video/Public/Movies/2009/CERN-MOVIE-2009-048/CERN-MOVIE-2009-048-Multirate-200-to-753-kbps-480x360.wmv', 'false', 288, 216, 'https://mediastream.cern.ch/MediaArchive/Video/Public/Movies/2009/CERN-MOVIE-2009-048/CERN-MOVIE-2009-048-posterframe-480x360-at-10-percent.jpg', '1178303', true, 'Video/Public/Movies/2009/CERN-MOVIE-2009-048/CERN-MOVIE-2009-048-0600-kbps-maxH-360-25-fps-audio-128-kbps-48-kHz-stereo.mp4'); Even the rain didn’t dampen the spirits, and it still managed to capture the ‘festival feeling’ with live music, beer and stalls from various CERN clubs set up outside Restaurant 1. The Powercuts on the podium after win...

  12. A time relay

    Energy Technology Data Exchange (ETDEWEB)

    Yosimura, K.; Sudzuki, Y.

    1981-06-18

    The synchronous micromotor of the time relay by means of a two staged cylindrical gear drive drives the gear wheel and the shaft of an actuating mechanism. The shaped drum of a cam mechanism, equipped with a vertical groove, which interacts in its upper part with a lever for driving the first commutating subassembly and in the lower, with a bent sector of a spring and plate movable contact of the second commutating subassembly, is attached to the lower end of the mechanism's shaft (V). The L-shaped lever of the second commutating subassembly's drive rests on a vertical rocking axle, located parallel to the shaft. Both pairs of spring and plate contacts are bracketed in two dielectric brackets which provide for a plane parallel disposition of the cited contacts. The operational time setting for the unit is a function of the initial angular position of the shaft, which is provided for by the attachment of a handle on its upper end.

  13. Sum-Rate Enhancement in Multiuser MIMO Decode-and-Forward Relay Broadcasting Channel with Energy Harvesting Relays

    KAUST Repository

    Benkhelifa, Fatma

    2016-09-20

    In this paper, we consider a multiuser multipleinput multiple-output (MIMO) decode-and-forward (DF) relay broadcasting channel (BC) with single source, multiple energy harvesting (EH) relays and multiple destinations. All the nodes are equipped with multiple antennas. The EH and information decoding (ID) tasks at the relays and destinations are separated over the time, which is termed as the time switching (TS) scheme. As optimal solutions for the sum-rate maximization problems of BC channels and the MIMO interference channels are hard to obtain, the end-to-end sum rate maximization problem of a multiuser MIMO DF relay BC channel is even harder. In this paper, we propose to tackle a simplified problem where we employ the block diagonalization (BD) procedure at the source, and we mitigate the interference between the relaydestination channels using an algorithm similar to the BD method. In order to show the relevance of our low complex proposed solution, we compare it to the minimum mean-square error (MMSE) solution that was shown in the literature to be equivalent to the solution of the sum-rate maximization in MIMO broadcasting interfering channels. We also investigate the time division multiple access (TDMA) solution which separates all the information transmissions from the source to the relays and from the relays to the destinations over time. We provide numerical results to show the relevance of our proposed solution, in comparison with the no co-channel interference (CCI) case, the TDMA based solution and the MMSE based solution.

  14. Sum-Rate Enhancement in Multiuser MIMO Decode-and-Forward Relay Broadcasting Channel with Energy Harvesting Relays

    KAUST Repository

    Benkhelifa, Fatma; Salem, Ahmed Sultan; Alouini, Mohamed-Slim

    2016-01-01

    In this paper, we consider a multiuser multipleinput multiple-output (MIMO) decode-and-forward (DF) relay broadcasting channel (BC) with single source, multiple energy harvesting (EH) relays and multiple destinations. All the nodes are equipped with multiple antennas. The EH and information decoding (ID) tasks at the relays and destinations are separated over the time, which is termed as the time switching (TS) scheme. As optimal solutions for the sum-rate maximization problems of BC channels and the MIMO interference channels are hard to obtain, the end-to-end sum rate maximization problem of a multiuser MIMO DF relay BC channel is even harder. In this paper, we propose to tackle a simplified problem where we employ the block diagonalization (BD) procedure at the source, and we mitigate the interference between the relaydestination channels using an algorithm similar to the BD method. In order to show the relevance of our low complex proposed solution, we compare it to the minimum mean-square error (MMSE) solution that was shown in the literature to be equivalent to the solution of the sum-rate maximization in MIMO broadcasting interfering channels. We also investigate the time division multiple access (TDMA) solution which separates all the information transmissions from the source to the relays and from the relays to the destinations over time. We provide numerical results to show the relevance of our proposed solution, in comparison with the no co-channel interference (CCI) case, the TDMA based solution and the MMSE based solution.

  15. Outage performance of two-way DF relaying systems with a new relay selection metric

    KAUST Repository

    Hyadi, Amal; Benjillali, Mustapha; Alouini, Mohamed-Slim

    2012-01-01

    This paper investigates a new constrained relay selection scheme for two-way relaying systems where two end terminals communicate simultaneously via a relay. The introduced technique is based on the maximization of the weighted sum rate of both

  16. A genetic algorithm for multiple relay selection in two-way relaying cognitive radio networks

    KAUST Repository

    Alsharoa, Ahmad M.; Ghazzai, Hakim; Alouini, Mohamed-Slim

    2013-01-01

    In this paper, we investigate a multiple relay selection scheme for two-way relaying cognitive radio networks where primary users and secondary users operate on the same frequency band. More specifically, cooperative relays using Amplifyand- Forward

  17. Decode and Zero-Forcing Forward Relaying with Relay Selection in Cognitive Radio Systems

    KAUST Repository

    Park, Kihong; Alouini, Mohamed-Slim

    2014-01-01

    In this paper, we investigate a cognitive radio (CR) relay network with multiple relay nodes that help forwarding the signal of CR users. Best relay selection is considered to take advantage of its low complexity of implementation. When the primary

  18. Reactive relay selection in underlay cognitive networks with fixed gain relays

    KAUST Repository

    Hussain, Syed Imtiaz; Alouini, Mohamed-Slim; Qaraqe, Khalid A.; Hasna, Mazen Omar

    2012-01-01

    Best relay selection is a bandwidth efficient technique for multiple relay environments without compromising the system performance. The problem of relay selection is more challenging in underlay cognitive networks due to strict interference

  19. The Effect of Single Pyramidal Neuron Firing Within Layer 2/3 and Layer 4 in Mouse V1.

    Science.gov (United States)

    Meyer, Jochen F; Golshani, Peyman; Smirnakis, Stelios M

    2018-01-01

    The influence of cortical cell spiking activity on nearby cells has been studied extensively in vitro . Less is known, however, about the impact of single cell firing on local cortical networks in vivo . In a pioneering study, Kwan and Dan (Kwan and Dan, 2012) reported that in mouse layer 2/3 (L2/3), under anesthesia , stimulating a single pyramidal cell recruits ~2.1% of neighboring units. Here we employ two-photon calcium imaging in layer 2/3 of mouse V1, in conjunction with single-cell patch clamp stimulation in layer 2/3 or layer 4, to probe, in both the awake and lightly anesthetized states , how (i) activating single L2/3 pyramidal neurons recruits neighboring units within L2/3 and from layer 4 (L4) to L2/3, and whether (ii) activating single pyramidal neurons changes population activity in local circuit. To do this, it was essential to develop an algorithm capable of quantifying how sensitive the calcium signal is at detecting effectively recruited units ("followers"). This algorithm allowed us to estimate the chance of detecting a follower as a function of the probability that an epoch of stimulation elicits one extra action potential (AP) in the follower cell. Using this approach, we found only a small fraction (layer-2/3 or layer-4 pyramidal neurons produces few (<1% of local units) reliable single-cell followers in L2/3 of mouse area V1, either under light anesthesia or in quiet wakefulness: instead, single cell stimulation was found to elevate aggregate population activity in a weak but highly distributed fashion.

  20. I-123 iomazenil single photon emission computed tomography for detecting loss of neuronal integrity in patients with traumatic brain injury

    OpenAIRE

    Abiko, Kagari; Ikoma, Katsunori; Shiga, Tohru; Katoh, Chietsugu; Hirata, Kenji; Kuge, Yuji; Kobayashi, Kentaro; Tamaki, Nagara

    2017-01-01

    Background Traumatic brain injury (TBI) causes brain dysfunction in many patients. Using C-11 flumazenil (FMZ) positron emission tomography (PET), we have detected and reported the loss of neuronal integrity, leading to brain dysfunction in TBI patients. Similarly to FMZ PET, I-123 iomazenil (IMZ) single photon emission computed tomography (SPECT) is widely used to determine the distribution of the benzodiazepine receptor (BZR) in the brain cortex. The purpose of this study is to examine whet...

  1. PPM-based relay communication schemes for wireless body area networks

    NARCIS (Netherlands)

    Zhang, P.; Willems, F.M.J.; Huang, Li

    2012-01-01

    This paper investigates cooperative communication schemes based on a single relay with pulse-position modulation (PPM) signaling, for enhancing energy efficiency of wireless body area networks (WBANs) in noncoherent channel settings. We explore cooperation between the source and the relay such that

  2. Low-Complexity Combining Schemes in Dual-Hop AF Relaying Systems

    KAUST Repository

    Gaaloul, Fakhreddine; Alouini, Mohamed-Slim; Radaydeh, Redha M.

    2011-01-01

    This paper investigates the performance of different low-complexity combining schemes in the context of dual-hop amplify-and-forward (AF) relaying networks. It is assumed that the relay uses single transmit (receive) antenna due to space limitation

  3. Single-cell analysis of peptide expression and electrophysiology of right parietal neurons involved in male copulation behavior of a simultaneous hermaphrodite.

    Science.gov (United States)

    El Filali, Z; de Boer, P A C M; Pieneman, A W; de Lange, R P J; Jansen, R F; Ter Maat, A; van der Schors, R C; Li, K W; van Straalen, N M; Koene, J M

    2015-12-01

    Male copulation is a complex behavior that requires coordinated communication between the nervous system and the peripheral reproductive organs involved in mating. In hermaphroditic animals, such as the freshwater snail Lymnaea stagnalis, this complexity increases since the animal can behave both as male and female. The performance of the sexual role as a male is coordinated via a neuronal communication regulated by many peptidergic neurons, clustered in the cerebral and pedal ganglia and dispersed in the pleural and parietal ganglia. By combining single-cell matrix-assisted laser mass spectrometry with retrograde staining and electrophysiology, we analyzed neuropeptide expression of single neurons of the right parietal ganglion and their axonal projections into the penial nerve. Based on the neuropeptide profile of these neurons, we were able to reconstruct a chemical map of the right parietal ganglion revealing a striking correlation with the earlier electrophysiological and neuroanatomical studies. Neurons can be divided into two main groups: (i) neurons that express heptapeptides and (ii) neurons that do not. The neuronal projection of the different neurons into the penial nerve reveals a pattern where (spontaneous) activity is related to branching pattern. This heterogeneity in both neurochemical anatomy and branching pattern of the parietal neurons reflects the complexity of the peptidergic neurotransmission involved in the regulation of male mating behavior in this simultaneous hermaphrodite.

  4. Brains are not just neurons. Comment on “Toward a computational framework for cognitive biology: Unifying approaches from cognitive neuroscience and comparative cognition” by Fitch

    Science.gov (United States)

    Huber, Ludwig

    2014-09-01

    This comment addresses the first component of Fitch's framework: the computational power of single neurons [3]. Although I agree that traditional models of neural computation have vastly underestimated the computational power of single neurons, I am hesitant to follow him completely. The exclusive focus on neurons is likely to underestimate the importance of other cells in the brain. In the last years, two such cell types have received appropriate attention by neuroscientists: interneurons and glia. Interneurons are small, tightly packed cells involved in the control of information processing in learning and memory. Rather than transmitting externally (like motor or sensory neurons), these neurons process information within internal circuits of the brain (therefore also called 'relay neurons'). Some specialized interneuron subtypes temporally regulate the flow of information in a given cortical circuit during relevant behavioral events [4]. In the human brain approx. 100 billion interneurons control information processing and are implicated in disorders such as epilepsy and Parkinson's.

  5. 3D Reconstruction and Standardization of the Rat Vibrissal Cortex for Precise Registration of Single Neuron Morphology

    Science.gov (United States)

    Egger, Robert; Narayanan, Rajeevan T.; Helmstaedter, Moritz; de Kock, Christiaan P. J.; Oberlaender, Marcel

    2012-01-01

    The three-dimensional (3D) structure of neural circuits is commonly studied by reconstructing individual or small groups of neurons in separate preparations. Investigation of structural organization principles or quantification of dendritic and axonal innervation thus requires integration of many reconstructed morphologies into a common reference frame. Here we present a standardized 3D model of the rat vibrissal cortex and introduce an automated registration tool that allows for precise placement of single neuron reconstructions. We (1) developed an automated image processing pipeline to reconstruct 3D anatomical landmarks, i.e., the barrels in Layer 4, the pia and white matter surfaces and the blood vessel pattern from high-resolution images, (2) quantified these landmarks in 12 different rats, (3) generated an average 3D model of the vibrissal cortex and (4) used rigid transformations and stepwise linear scaling to register 94 neuron morphologies, reconstructed from in vivo stainings, to the standardized cortex model. We find that anatomical landmarks vary substantially across the vibrissal cortex within an individual rat. In contrast, the 3D layout of the entire vibrissal cortex remains remarkably preserved across animals. This allows for precise registration of individual neuron reconstructions with approximately 30 µm accuracy. Our approach could be used to reconstruct and standardize other anatomically defined brain areas and may ultimately lead to a precise digital reference atlas of the rat brain. PMID:23284282

  6. Single Neurons in the Avian Auditory Cortex Encode Individual Identity and Propagation Distance in Naturally Degraded Communication Calls.

    Science.gov (United States)

    Mouterde, Solveig C; Elie, Julie E; Mathevon, Nicolas; Theunissen, Frédéric E

    2017-03-29

    One of the most complex tasks performed by sensory systems is "scene analysis": the interpretation of complex signals as behaviorally relevant objects. The study of this problem, universal to species and sensory modalities, is particularly challenging in audition, where sounds from various sources and localizations, degraded by propagation through the environment, sum to form a single acoustical signal. Here we investigated in a songbird model, the zebra finch, the neural substrate for ranging and identifying a single source. We relied on ecologically and behaviorally relevant stimuli, contact calls, to investigate the neural discrimination of individual vocal signature as well as sound source distance when calls have been degraded through propagation in a natural environment. Performing electrophysiological recordings in anesthetized birds, we found neurons in the auditory forebrain that discriminate individual vocal signatures despite long-range degradation, as well as neurons discriminating propagation distance, with varying degrees of multiplexing between both information types. Moreover, the neural discrimination performance of individual identity was not affected by propagation-induced degradation beyond what was induced by the decreased intensity. For the first time, neurons with distance-invariant identity discrimination properties as well as distance-discriminant neurons are revealed in the avian auditory cortex. Because these neurons were recorded in animals that had prior experience neither with the vocalizers of the stimuli nor with long-range propagation of calls, we suggest that this neural population is part of a general-purpose system for vocalizer discrimination and ranging. SIGNIFICANCE STATEMENT Understanding how the brain makes sense of the multitude of stimuli that it continually receives in natural conditions is a challenge for scientists. Here we provide a new understanding of how the auditory system extracts behaviorally relevant information

  7. Induction of specific neuron types by overexpression of single transcription factors.

    Science.gov (United States)

    Teratani-Ota, Yusuke; Yamamizu, Kohei; Piao, Yulan; Sharova, Lioudmila; Amano, Misa; Yu, Hong; Schlessinger, David; Ko, Minoru S H; Sharov, Alexei A

    2016-10-01

    Specific neuronal types derived from embryonic stem cells (ESCs) can facilitate mechanistic studies and potentially aid in regenerative medicine. Existing induction methods, however, mostly rely on the effects of the combined action of multiple added growth factors, which generally tend to result in mixed populations of neurons. Here, we report that overexpression of specific transcription factors (TFs) in ESCs can rather guide the differentiation of ESCs towards specific neuron lineages. Analysis of data on gene expression changes 2 d after induction of each of 185 TFs implicated candidate TFs for further ESC differentiation studies. Induction of 23 TFs (out of 49 TFs tested) for 6 d facilitated neural differentiation of ESCs as inferred from increased proportion of cells with neural progenitor marker PSA-NCAM. We identified early activation of the Notch signaling pathway as a common feature of most potent inducers of neural differentiation. The majority of neuron-like cells generated by induction of Ascl1, Smad7, Nr2f1, Dlx2, Dlx4, Nr2f2, Barhl2, and Lhx1 were GABA-positive and expressed other markers of GABAergic neurons. In the same way, we identified Lmx1a and Nr4a2 as inducers for neurons bearing dopaminergic markers and Isl1, Fezf2, and St18 for cholinergic motor neurons. A time-course experiment with induction of Ascl1 showed early upregulation of most neural-specific messenger RNA (mRNA) and microRNAs (miRNAs). Sets of Ascl1-induced mRNAs and miRNAs were enriched in Ascl1 targets. In further studies, enrichment of cells obtained with the induction of Ascl1, Smad7, and Nr2f1 using microbeads resulted in essentially pure population of neuron-like cells with expression profiles similar to neural tissues and expressed markers of GABAergic neurons. In summary, this study indicates that induction of transcription factors is a promising approach to generate cultures that show the transcription profiles characteristic of specific neural cell types.

  8. A Single Pair of Serotonergic Neurons Counteracts Serotonergic Inhibition of Ethanol Attraction in Drosophila.

    Science.gov (United States)

    Xu, Li; He, Jianzheng; Kaiser, Andrea; Gräber, Nikolas; Schläger, Laura; Ritze, Yvonne; Scholz, Henrike

    2016-01-01

    Attraction to ethanol is common in both flies and humans, but the neuromodulatory mechanisms underlying this innate attraction are not well understood. Here, we dissect the function of the key regulator of serotonin signaling-the serotonin transporter-in innate olfactory attraction to ethanol in Drosophila melanogaster. We generated a mutated version of the serotonin transporter that prolongs serotonin signaling in the synaptic cleft and is targeted via the Gal4 system to different sets of serotonergic neurons. We identified four serotonergic neurons that inhibit the olfactory attraction to ethanol and two additional neurons that counteract this inhibition by strengthening olfactory information. Our results reveal that compensation can occur on the circuit level and that serotonin has a bidirectional function in modulating the innate attraction to ethanol. Given the evolutionarily conserved nature of the serotonin transporter and serotonin, the bidirectional serotonergic mechanisms delineate a basic principle for how random behavior is switched into targeted approach behavior.

  9. Characterizing human stem cell-derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research.

    Science.gov (United States)

    Young, Gareth T; Gutteridge, Alex; Fox, Heather DE; Wilbrey, Anna L; Cao, Lishuang; Cho, Lily T; Brown, Adam R; Benn, Caroline L; Kammonen, Laura R; Friedman, Julia H; Bictash, Magda; Whiting, Paul; Bilsland, James G; Stevens, Edward B

    2014-08-01

    The generation of human sensory neurons by directed differentiation of pluripotent stem cells opens new opportunities for investigating the biology of pain. The inability to generate this cell type has meant that up until now their study has been reliant on the use of rodent models. Here, we use a combination of population and single-cell techniques to perform a detailed molecular, electrophysiological, and pharmacological phenotyping of sensory neurons derived from human embryonic stem cells. We describe the evolution of cell populations over 6 weeks of directed differentiation; a process that results in the generation of a largely homogeneous population of neurons that are both molecularly and functionally comparable to human sensory neurons derived from mature dorsal root ganglia. This work opens the prospect of using pluripotent stem-cell-derived sensory neurons to study human neuronal physiology and as in vitro models for drug discovery in pain and sensory disorders.

  10. Characterizing Human Stem Cell–derived Sensory Neurons at the Single-cell Level Reveals Their Ion Channel Expression and Utility in Pain Research

    Science.gov (United States)

    Young, Gareth T; Gutteridge, Alex; Fox, Heather DE; Wilbrey, Anna L; Cao, Lishuang; Cho, Lily T; Brown, Adam R; Benn, Caroline L; Kammonen, Laura R; Friedman, Julia H; Bictash, Magda; Whiting, Paul; Bilsland, James G; Stevens, Edward B

    2014-01-01

    The generation of human sensory neurons by directed differentiation of pluripotent stem cells opens new opportunities for investigating the biology of pain. The inability to generate this cell type has meant that up until now their study has been reliant on the use of rodent models. Here, we use a combination of population and single-cell techniques to perform a detailed molecular, electrophysiological, and pharmacological phenotyping of sensory neurons derived from human embryonic stem cells. We describe the evolution of cell populations over 6 weeks of directed differentiation; a process that results in the generation of a largely homogeneous population of neurons that are both molecularly and functionally comparable to human sensory neurons derived from mature dorsal root ganglia. This work opens the prospect of using pluripotent stem-cell–derived sensory neurons to study human neuronal physiology and as in vitro models for drug discovery in pain and sensory disorders. PMID:24832007

  11. Speech-to-Speech Relay Service

    Science.gov (United States)

    Consumer Guide Speech to Speech Relay Service Speech-to-Speech (STS) is one form of Telecommunications Relay Service (TRS). TRS is a service that allows persons with hearing and speech disabilities ...

  12. Relay selection from an effective capacity perspective

    KAUST Repository

    Yang, Yuli; Ma, Hao; Aï ssa, Sonia

    2013-01-01

    proposed scheme in certain scenarios. Moreover, the analysis presented herein offers a convenient tool to the relaying transmission design, specifically on which relay selection scheme should be used as well as how to choose the receiving strategy between

  13. Relay self interference minimisation using tapped filter

    KAUST Repository

    Jazzar, Saleh; Al-Naffouri, Tareq Y.

    2013-01-01

    In this paper we introduce a self interference (SI) estimation and minimisation technique for amplify and forward relays. Relays are used to help forward signals between a transmitter and a receiver. This helps increase the signal coverage

  14. Handover Framework for Relay Enhanced LTE Networks

    DEFF Research Database (Denmark)

    Teyeb, Oumer Mohammed; Van Phan, Vinh; Raaf, Bernhard

    2009-01-01

    Relaying is one of the proposed technologies for future releases of UTRAN Long Term Evolution (LTE) networks. Introducing relaying is expected to increase the coverage and capacity of LTE networks. In order to enable relaying, the architecture, protocol and radio resource management procedures...... of LTE, such as handover, have to be modified. A user can be handed over not only between two base stations, but also between relays and base stations, and between two relays. With the introduction of relaying, there is a need for a new procedure to hand over a relay and all its associated users...... to another base station, allowing a flexible and dynamic relay deployment. In this paper, we extend the LTE release 8 handover mechanisms so that it can accommodate these new handover functionalities in a flexible manner....

  15. An economically viable space power relay system

    Science.gov (United States)

    Bekey, Ivan; Boudreault, Richard

    1999-09-01

    This paper describes and analyzes the economics of a power relay system that takes advantage of recent technological advances to implement a system that is economically viable. A series of power relay systems are described and analyzed which transport power ranging from 1,250 megawatts to 5,000 megawatts, and distribute it to receiving sites at transcontinental distances. Two classes of systems are discussed—those with a single reflector and delivering all the power to a single rectenna, and a second type which has multiple reflectors and distributes it to 10 rectenna sites, sharing power among them. It is shown that when offering electricity at prices competitive to those prevalent in developed cities in the US that a low IRR is inevitable, and economic feasibility of a business is unlikely. However, when the target market is Japan where the prevalent electricity prices are much greater, that an IRR exceeding 65% is readily attainable. This is extremely attractive to potential investors, making capitalization of a venture likely. The paper shows that the capital investment required for the system can be less than 1 per installed watt, contributing less than 0.02 /KW-hr to the cost of energy provision. Since selling prices in feasible regions range from 0.18 to over 030 $/kW-hr, these costs are but a small fraction of the operating expenses. Thus a very large IRR is possible for such a business.

  16. Operant conditioning of synaptic and spiking activity patterns in single hippocampal neurons.

    Science.gov (United States)

    Ishikawa, Daisuke; Matsumoto, Nobuyoshi; Sakaguchi, Tetsuya; Matsuki, Norio; Ikegaya, Yuji

    2014-04-02

    Learning is a process of plastic adaptation through which a neural circuit generates a more preferable outcome; however, at a microscopic level, little is known about how synaptic activity is patterned into a desired configuration. Here, we report that animals can generate a specific form of synaptic activity in a given neuron in the hippocampus. In awake, head-restricted mice, we applied electrical stimulation to the lateral hypothalamus, a reward-associated brain region, when whole-cell patch-clamped CA1 neurons exhibited spontaneous synaptic activity that met preset criteria. Within 15 min, the mice learned to generate frequently the excitatory synaptic input pattern that satisfied the criteria. This reinforcement learning of synaptic activity was not observed for inhibitory input patterns. When a burst unit activity pattern was conditioned in paired and nonpaired paradigms, the frequency of burst-spiking events increased and decreased, respectively. The burst reinforcement occurred in the conditioned neuron but not in other adjacent neurons; however, ripple field oscillations were concomitantly reinforced. Neural conditioning depended on activation of NMDA receptors and dopamine D1 receptors. Acutely stressed mice and depression model mice that were subjected to forced swimming failed to exhibit the neural conditioning. This learning deficit was rescued by repetitive treatment with fluoxetine, an antidepressant. Therefore, internally motivated animals are capable of routing an ongoing action potential series into a specific neural pathway of the hippocampal network.

  17. Divisive normalization and neuronal oscillations in a single hierarchical framework of selective visual attention

    NARCIS (Netherlands)

    Montijn, J.S.; Klink, P.C.; van Wezel, R.J.A.

    2012-01-01

    Divisive normalization models of covert attention commonly use spike rate modulations as indicators of the effect of top-down attention. In addition, an increasing number of studies have shown that top-down attention increases the synchronization of neuronal oscillations as well, particularly in

  18. Joint opportunistic scheduling and network coding for bidirectional relay channel

    KAUST Repository

    Shaqfeh, Mohammad

    2013-07-01

    In this paper, we consider a two-way communication system in which two users communicate with each other through an intermediate relay over block-fading channels. We investigate the optimal opportunistic scheduling scheme in order to maximize the long-term average transmission rate in the system assuming symmetric information flow between the two users. Based on the channel state information, the scheduler decides that either one of the users transmits to the relay, or the relay transmits to a single user or broadcasts to both users a combined version of the two users\\' transmitted information by using linear network coding. We obtain the optimal scheduling scheme by using the Lagrangian dual problem. Furthermore, in order to characterize the gains of network coding and opportunistic scheduling, we compare the achievable rate of the system versus suboptimal schemes in which the gains of network coding and opportunistic scheduling are partially exploited. © 2013 IEEE.

  19. 76 FR 24442 - Structure and Practices of the Video Relay Service Program; Telecommunications Relay Services and...

    Science.gov (United States)

    2011-05-02

    ... same meaning as the terms ``small business,'' ``small organization,'' and ``small governmental...] Structure and Practices of the Video Relay Service Program; Telecommunications Relay Services and Speech-to... Commission's Structure and Practices of the Video Relay Service Program; Telecommunications Relay Services...

  20. Quantum cryptography with an ideal local relay

    DEFF Research Database (Denmark)

    Spedalieri, Gaetana; Ottaviani, Carlo; Braunstein, Samuel L.

    2015-01-01

    We consider two remote parties connected to a relay by two quantum channels. To generate a secret key, they transmit coherent states to the relay, where the states are subject to a continuous-variable (CV) Bell detection. We study the ideal case where Alice's channel is lossless, i.e., the relay ...

  1. SIP-Based Single Neuron Stochastic Predictive Control for Non-Gaussian Networked Control Systems with Uncertain Metrology Delays

    Directory of Open Access Journals (Sweden)

    Xinying Xu

    2018-06-01

    Full Text Available In this paper, a novel data-driven single neuron predictive control strategy is proposed for non-Gaussian networked control systems with metrology delays in the information theory framework. Firstly, survival information potential (SIP, instead of minimum entropy, is used to formulate the performance index to characterize the randomness of the considered systems, which is calculated by oversampling method. Then the minimum values can be computed by optimizing the SIP-based performance index. Finally, the proposed strategy, minimum entropy method and mean square error (MSE are applied to a networked motor control system, and results demonstrated the effectiveness of the proposed strategy.

  2. Stability and Hopf Bifurcation of Fractional-Order Complex-Valued Single Neuron Model with Time Delay

    Science.gov (United States)

    Wang, Zhen; Wang, Xiaohong; Li, Yuxia; Huang, Xia

    2017-12-01

    In this paper, the problems of stability and Hopf bifurcation in a class of fractional-order complex-valued single neuron model with time delay are addressed. With the help of the stability theory of fractional-order differential equations and Laplace transforms, several new sufficient conditions, which ensure the stability of the system are derived. Taking the time delay as the bifurcation parameter, Hopf bifurcation is investigated and the critical value of the time delay for the occurrence of Hopf bifurcation is determined. Finally, two representative numerical examples are given to show the effectiveness of the theoretical results.

  3. Single-Cell RNA-Seq of Mouse Dopaminergic Neurons Informs Candidate Gene Selection for Sporadic Parkinson Disease.

    Science.gov (United States)

    Hook, Paul W; McClymont, Sarah A; Cannon, Gabrielle H; Law, William D; Morton, A Jennifer; Goff, Loyal A; McCallion, Andrew S

    2018-03-01

    Genetic variation modulating risk of sporadic Parkinson disease (PD) has been primarily explored through genome-wide association studies (GWASs). However, like many other common genetic diseases, the impacted genes remain largely unknown. Here, we used single-cell RNA-seq to characterize dopaminergic (DA) neuron populations in the mouse brain at embryonic and early postnatal time points. These data facilitated unbiased identification of DA neuron subpopulations through their unique transcriptional profiles, including a postnatal neuroblast population and substantia nigra (SN) DA neurons. We use these population-specific data to develop a scoring system to prioritize candidate genes in all 49 GWAS intervals implicated in PD risk, including genes with known PD associations and many with extensive supporting literature. As proof of principle, we confirm that the nigrostriatal pathway is compromised in Cplx1-null mice. Ultimately, this systematic approach establishes biologically pertinent candidates and testable hypotheses for sporadic PD, informing a new era of PD genetic research. Copyright © 2018 American Society of Human Genetics. All rights reserved.

  4. Wireless Sensor Network Congestion Control Based on Standard Particle Swarm Optimization and Single Neuron PID.

    Science.gov (United States)

    Yang, Xiaoping; Chen, Xueying; Xia, Riting; Qian, Zhihong

    2018-04-19

    Aiming at the problem of network congestion caused by the large number of data transmissions in wireless routing nodes of wireless sensor network (WSN), this paper puts forward an algorithm based on standard particle swarm⁻neural PID congestion control (PNPID). Firstly, PID control theory was applied to the queue management of wireless sensor nodes. Then, the self-learning and self-organizing ability of neurons was used to achieve online adjustment of weights to adjust the proportion, integral and differential parameters of the PID controller. Finally, the standard particle swarm optimization to neural PID (NPID) algorithm of initial values of proportion, integral and differential parameters and neuron learning rates were used for online optimization. This paper describes experiments and simulations which show that the PNPID algorithm effectively stabilized queue length near the expected value. At the same time, network performance, such as throughput and packet loss rate, was greatly improved, which alleviated network congestion and improved network QoS.

  5. Predicting the response of olfactory sensory neurons to odor mixtures from single odor response

    Science.gov (United States)

    Marasco, Addolorata; de Paris, Alessandro; Migliore, Michele

    2016-04-01

    The response of olfactory receptor neurons to odor mixtures is not well understood. Here, using experimental constraints, we investigate the mathematical structure of the odor response space and its consequences. The analysis suggests that the odor response space is 3-dimensional, and predicts that the dose-response curve of an odor receptor can be obtained, in most cases, from three primary components with specific properties. This opens the way to an objective procedure to obtain specific olfactory receptor responses by manipulating mixtures in a mathematically predictable manner. This result is general and applies, independently of the number of odor components, to any olfactory sensory neuron type with a response curve that can be represented as a sigmoidal function of the odor concentration.

  6. Bayesian nonparametric modeling for comparison of single-neuron firing intensities.

    Science.gov (United States)

    Kottas, Athanasios; Behseta, Sam

    2010-03-01

    We propose a fully inferential model-based approach to the problem of comparing the firing patterns of a neuron recorded under two distinct experimental conditions. The methodology is based on nonhomogeneous Poisson process models for the firing times of each condition with flexible nonparametric mixture prior models for the corresponding intensity functions. We demonstrate posterior inferences from a global analysis, which may be used to compare the two conditions over the entire experimental time window, as well as from a pointwise analysis at selected time points to detect local deviations of firing patterns from one condition to another. We apply our method on two neurons recorded from the primary motor cortex area of a monkey's brain while performing a sequence of reaching tasks.

  7. Predicting the response of olfactory sensory neurons to odor mixtures from single odor response

    OpenAIRE

    Marasco, Addolorata; De Paris, Alessandro; Migliore, Michele

    2016-01-01

    The response of olfactory receptor neurons to odor mixtures is not well understood. Here, using experimental constraints, we investigate the mathematical structure of the odor response space and its consequences. The analysis suggests that the odor response space is 3-dimensional, and predicts that the dose-response curve of an odor receptor can be obtained, in most cases, from three primary components with specific properties. This opens the way to an objective procedure to obtain specific o...

  8. Single-molecule folding mechanism of an EF-hand neuronal calcium sensor

    DEFF Research Database (Denmark)

    Heiðarsson, Pétur Orri; Otazo, Mariela R.; Bellucci, Luca

    2013-01-01

    EF-hand calcium sensors respond structurally to changes in intracellular Ca2+ concentration, triggering diverse cellular responses and resulting in broad interactomes. Despite impressive advances in decoding their structure-function relationships, the folding mechanism of neuronal calcium sensors...... of the N domain, showing striking interdomain dependence. Molecular dynamics results reveal the atomistic details of the unfolding process and rationalize the different domain stabilities during mechanical unfolding. Through constant-force experiments and hidden Markov model analysis, the free energy...

  9. Divisive Normalization and Neuronal Oscillations in a Single Hierarchical Framework of Selective Visual Attention

    OpenAIRE

    Montijn, Jorrit Steven; Klink, P. Christaan; van Wezel, Richard J. A.

    2012-01-01

    Divisive normalization models of covert attention commonly use spike rate modulations as indicators of the effect of top-down attention. In addition, an increasing number of studies have shown that top-down attention increases the synchronization of neuronal oscillations as well, particularly in gamma-band frequencies (25–100 Hz). Although modulations of spike rate and synchronous oscillations are not mutually exclusive as mechanisms of attention, there has thus far been little effort to inte...

  10. Switched diversity strategies for dual-hop amplify-and-forward relaying systems

    KAUST Repository

    Gaaloul, Fakhreddine; Radaydeh, Redha Mahmoud Mesleh; Alouini, Mohamed-Slim

    2012-01-01

    This study investigates different receive single-branch switch-based diversity schemes for dual-hop amplify-and-forward relaying networks. Specifically, three receive processing algorithms are adopted, in which the receive branch is selected using

  11. Spoiled Onions: Exposing Malicious Tor Exit Relays

    OpenAIRE

    Winter, Philipp; Lindskog, Stefan

    2014-01-01

    Several hundred Tor exit relays together push more than 1 GiB/s of network traffic. However, it is easy for exit relays to snoop and tamper with anonymised network traffic and as all relays are run by independent volunteers, not all of them are innocuous. In this paper, we seek to expose malicious exit relays and document their actions. First, we monitored the Tor network after developing a fast and modular exit relay scanner. We implemented several scanning modules for detecting common attac...

  12. I-123 iomazenil single photon emission computed tomography for detecting loss of neuronal integrity in patients with traumatic brain injury.

    Science.gov (United States)

    Abiko, Kagari; Ikoma, Katsunori; Shiga, Tohru; Katoh, Chietsugu; Hirata, Kenji; Kuge, Yuji; Kobayashi, Kentaro; Tamaki, Nagara

    2017-12-01

    Traumatic brain injury (TBI) causes brain dysfunction in many patients. Using C-11 flumazenil (FMZ) positron emission tomography (PET), we have detected and reported the loss of neuronal integrity, leading to brain dysfunction in TBI patients. Similarly to FMZ PET, I-123 iomazenil (IMZ) single photon emission computed tomography (SPECT) is widely used to determine the distribution of the benzodiazepine receptor (BZR) in the brain cortex. The purpose of this study is to examine whether IMZ SPECT is as useful as FMZ PET for evaluating the loss of neuronal integrity in TBI patients. The subjects of this study were seven patients who suffered from neurobehavioral disability. They underwent IMZ SPECT and FMZ PET. Nondisplaceable binding potential (BP ND ) was calculated from FMZ PET images. The uptake of IMZ was evaluated on the basis of lesion-to-pons ratio (LPR). The locations of low uptake levels were visually evaluated both in IMZ SPECT and FMZ PET images. We compared FMZ BP ND and (LPR-1) of IMZ SPECT. In the visual assessment, FMZ BP ND decreased in 11 regions. In IMZ SPECT, low uptake levels were observed in eight of the 11 regions. The rate of concordance between FMZ PET and IMZ SPECT was 72.7%. The mean values IMZ (LPR-1) (1.95 ± 1.01) was significantly lower than that of FMZ BP ND (2.95 ± 0.80 mL/mL). There was good correlation between FMZ BP ND and IMZ (LPR-1) (r = 0.80). IMZ SPECT findings were almost the same as FMZ PET findings in TBI patients. The results indicated that IMZ SPECT is useful for evaluating the loss of neuronal integrity. Because IMZ SPECT can be performed in various facilities, IMZ SPECT may become widely adopted for evaluating the loss of neuronal integrity.

  13. On the benefits of location-based relay selection in mobile wireless networks

    DEFF Research Database (Denmark)

    Nielsen, Jimmy Jessen; Madsen, Tatiana Kozlova; Schwefel, Hans-Peter

    2016-01-01

    We consider infrastructure-based mobile networks that are assisted by a single relay transmission where both the downstream destination and relay nodes are mobile. Selecting the optimal transmission path for a destination node requires up-to-date link quality estimates of all relevant links....... If the relay selection is based on link quality measurements, the number of links to update grows quadratically with the number of nodes, and measurements need to be updated frequently when nodes are mobile. In this paper, we consider a location-based relay selection scheme where link qualities are estimated...... from node positions; in the scenario of a node-based location system such as GPS, the location-based approach reduces signaling overhead, which in this case only grows linearly with the number of nodes. This paper studies these two relay selection approaches and investigates how they are affected...

  14. Relay Selection with Limited and Noisy Feedback

    KAUST Repository

    Eltayeb, Mohammed E.

    2016-01-28

    Relay selection is a simple technique that achieves spatial diversity in cooperative relay networks. Nonetheless, relay selection algorithms generally require error-free channel state information (CSI) from all cooperating relays. Practically, CSI acquisition generates a great deal of feedback overhead that could result in significant transmission delays. In addition to this, the fed back channel information is usually corrupted by additive noise. This could lead to transmission outages if the central node selects the set of cooperating relays based on inaccurate feedback information. In this paper, we propose a relay selection algorithm that tackles the above challenges. Instead of allocating each relay a dedicated channel for feedback, all relays share a pool of feedback channels. Following that, each relay feeds back its identity only if its effective channel (source-relay-destination) exceeds a threshold. After deriving closed-form expressions for the feedback load and the achievable rate, we show that the proposed algorithm drastically reduces the feedback overhead and achieves a rate close to that obtained by selection algorithms with dedicated error-free feedback from all relays. © 2015 IEEE.

  15. Identifying cochlear implant channels with poor electrode-neuron interface: partial tripolar, single-channel thresholds and psychophysical tuning curves.

    Science.gov (United States)

    Bierer, Julie Arenberg; Faulkner, Kathleen F

    2010-04-01

    The goal of this study was to evaluate the ability of a threshold measure, made with a restricted electrode configuration, to identify channels exhibiting relatively poor spatial selectivity. With a restricted electrode configuration, channel-to-channel variability in threshold may reflect variations in the interface between the electrodes and auditory neurons (i.e., nerve survival, electrode placement, and tissue impedance). These variations in the electrode-neuron interface should also be reflected in psychophysical tuning curve (PTC) measurements. Specifically, it is hypothesized that high single-channel thresholds obtained with the spatially focused partial tripolar (pTP) electrode configuration are predictive of wide or tip-shifted PTCs. Data were collected from five cochlear implant listeners implanted with the HiRes90k cochlear implant (Advanced Bionics Corp., Sylmar, CA). Single-channel thresholds and most comfortable listening levels were obtained for stimuli that varied in presumed electrical field size by using the pTP configuration for which a fraction of current (sigma) from a center-active electrode returns through two neighboring electrodes and the remainder through a distant indifferent electrode. Forward-masked PTCs were obtained for channels with the highest, lowest, and median tripolar (sigma = 1 or 0.9) thresholds. The probe channel and level were fixed and presented with either the monopolar (sigma = 0) or a more focused pTP (sigma > or = 0.55) configuration. The masker channel and level were varied, whereas the configuration was fixed to sigma = 0.5. A standard, three-interval, two-alternative forced choice procedure was used for thresholds and masked levels. Single-channel threshold and variability in threshold across channels systematically increased as the compensating current, sigma, increased and the presumed electrical field became more focused. Across subjects, channels with the highest single-channel thresholds, when measured with a

  16. Single-Cell Detection of Secreted Aβ and sAPPα from Human IPSC-Derived Neurons and Astrocytes.

    Science.gov (United States)

    Liao, Mei-Chen; Muratore, Christina R; Gierahn, Todd M; Sullivan, Sarah E; Srikanth, Priya; De Jager, Philip L; Love, J Christopher; Young-Pearse, Tracy L

    2016-02-03

    Secreted factors play a central role in normal and pathological processes in every tissue in the body. The brain is composed of a highly complex milieu of different cell types and few methods exist that can identify which individual cells in a complex mixture are secreting specific analytes. By identifying which cells are responsible, we can better understand neural physiology and pathophysiology, more readily identify the underlying pathways responsible for analyte production, and ultimately use this information to guide the development of novel therapeutic strategies that target the cell types of relevance. We present here a method for detecting analytes secreted from single human induced pluripotent stem cell (iPSC)-derived neural cells and have applied the method to measure amyloid β (Aβ) and soluble amyloid precursor protein-alpha (sAPPα), analytes central to Alzheimer's disease pathogenesis. Through these studies, we have uncovered the dynamic range of secretion profiles of these analytes from single iPSC-derived neuronal and glial cells and have molecularly characterized subpopulations of these cells through immunostaining and gene expression analyses. In examining Aβ and sAPPα secretion from single cells, we were able to identify previously unappreciated complexities in the biology of APP cleavage that could not otherwise have been found by studying averaged responses over pools of cells. This technique can be readily adapted to the detection of other analytes secreted by neural cells, which would have the potential to open new perspectives into human CNS development and dysfunction. We have established a technology that, for the first time, detects secreted analytes from single human neurons and astrocytes. We examine secretion of the Alzheimer's disease-relevant factors amyloid β (Aβ) and soluble amyloid precursor protein-alpha (sAPPα) and present novel findings that could not have been observed without a single-cell analytical platform. First, we

  17. Secure amplify-and-forward untrusted relaying networks using cooperative jamming and zero-forcing cancelation

    KAUST Repository

    Park, Kihong

    2015-12-03

    In this paper, we investigate secure transmission in untrusted amplify-and-forward half-duplex relaying networks with the help of cooperative jamming at the destination (CJD). Under the assumption of full channel state information (CSI), conventional CJD using self-interference cancelation at the destination is efficient when the untrusted relay has no capability to suppress the jamming signal. However, if the source and destination are equipped with a single antenna and the only untrusted relay is equipped with N multiple antennas, it can remove the jamming signal from the received signal by linear filters and the full multiplexing gain of relaying cannot be achievable with the conventional CJD due to the saturation of the secrecy rate at the high transmit power regime. We propose in this paper new CJD scheme where neither destination nor relay can acquire CSI of relay-destination link. Our proposed scheme utilizes zero-forcing cancelation based on known jamming signals instead of self-interference subtraction, while the untrusted relay cannot suppress the jamming signals due to the lack of CSI. We show that the secrecy rate of the proposed scheme can enjoy a half of multiplexing gain in half-duplex relaying while that of conventional CJD is saturated at high transmit power for N ???2. The impact of channel estimation error at the destination is also investigated to show the robustness of the proposed scheme against strong estimation errors.

  18. A Hybrid Fuzzy Time Series Approach Based on Fuzzy Clustering and Artificial Neural Network with Single Multiplicative Neuron Model

    Directory of Open Access Journals (Sweden)

    Ozge Cagcag Yolcu

    2013-01-01

    Full Text Available Particularly in recent years, artificial intelligence optimization techniques have been used to make fuzzy time series approaches more systematic and improve forecasting performance. Besides, some fuzzy clustering methods and artificial neural networks with different structures are used in the fuzzification of observations and determination of fuzzy relationships, respectively. In approaches considering the membership values, the membership values are determined subjectively or fuzzy outputs of the system are obtained by considering that there is a relation between membership values in identification of relation. This necessitates defuzzification step and increases the model error. In this study, membership values were obtained more systematically by using Gustafson-Kessel fuzzy clustering technique. The use of artificial neural network with single multiplicative neuron model in identification of fuzzy relation eliminated the architecture selection problem as well as the necessity for defuzzification step by constituting target values from real observations of time series. The training of artificial neural network with single multiplicative neuron model which is used for identification of fuzzy relation step is carried out with particle swarm optimization. The proposed method is implemented using various time series and the results are compared with those of previous studies to demonstrate the performance of the proposed method.

  19. Integration of Plasticity Mechanisms within a Single Sensory Neuron of C. elegans Actuates a Memory.

    Science.gov (United States)

    Hawk, Josh D; Calvo, Ana C; Liu, Ping; Almoril-Porras, Agustin; Aljobeh, Ahmad; Torruella-Suárez, María Luisa; Ren, Ivy; Cook, Nathan; Greenwood, Joel; Luo, Linjiao; Wang, Zhao-Wen; Samuel, Aravinthan D T; Colón-Ramos, Daniel A

    2018-01-17

    Neural plasticity, the ability of neurons to change their properties in response to experiences, underpins the nervous system's capacity to form memories and actuate behaviors. How different plasticity mechanisms act together in vivo and at a cellular level to transform sensory information into behavior is not well understood. We show that in Caenorhabditis elegans two plasticity mechanisms-sensory adaptation and presynaptic plasticity-act within a single cell to encode thermosensory information and actuate a temperature preference memory. Sensory adaptation adjusts the temperature range of the sensory neuron (called AFD) to optimize detection of temperature fluctuations associated with migration. Presynaptic plasticity in AFD is regulated by the conserved kinase nPKCε and transforms thermosensory information into a behavioral preference. Bypassing AFD presynaptic plasticity predictably changes learned behavioral preferences without affecting sensory responses. Our findings indicate that two distinct neuroplasticity mechanisms function together through a single-cell logic system to enact thermotactic behavior. VIDEO ABSTRACT. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Fast calcium transients translate the distribution and conduction of neural activity in different regions of a single sensory neuron.

    Science.gov (United States)

    Purali, Nuhan

    2017-09-01

    In the present study, cytosolic calcium concentration changes were recorded in response to various forms of excitations, using the fluorescent calcium indicator dye OG-BAPTA1 together with the current or voltage clamp methods in stretch receptor neurons of crayfish. A single action potential evoked a rise in the resting calcium level in the axon and axonal hillock, whereas an impulse train or a large saturating current injection would be required to evoke an equivalent response in the dendrite region. Under voltage clamp conditions, amplitude differences between axon and dendrite responses vanished completely. The fast activation time and the modulation of the response by extracellular calcium concentration changes indicated that the evoked calcium transients might be mediated by calcium entry into the cytosol through a voltage-gated calcium channel. The decay of the responses was slow and sensitive to extracellular sodium and calcium concentrations as well as exposure to 1-10 mM NiCl 2 and 10-500 µM lanthanum. Thus, a sodium calcium exchanger and a calcium ATPase might be responsible for calcium extrusion from the cytosol. Present results indicate that the calcium indicator OG-BAPTA1 might be an efficient but indirect way of monitoring regional membrane potential differences in a single neuron.

  1. Threshold-Based Relay Selection for Detect-and-Forward Relaying in Cooperative Wireless Networks

    Directory of Open Access Journals (Sweden)

    Fan Yijia

    2010-01-01

    Full Text Available This paper studies two-hop cooperative demodulate-and-forward relaying using multiple relays in wireless networks. A threshold based relay selection scheme is considered, in which the reliable relays are determined by comparing source-relay SNR to a threshold, and one of the reliable relays is selected by the destination based on relay-destination SNR. The exact bit error rate of this scheme is derived, and a simple threshold function is proposed. It is shown that the network achieves full diversity order ( under the proposed threshold, where is the number of relays in the network. Unlike some other full diversity achieving protocols in the literature, the requirement that the instantaneous/average SNRs of the source-relay links be known at the destination is eliminated using the appropriate SNR threshold.

  2. Alternate transmission with half-duplex relaying in MIMO interference relay networks

    KAUST Repository

    Park, Seongho

    2013-12-01

    In this paper, we consider an alternate transmission scheme for a multiple-input multiple-output interference relay channel where multiple sources transmit their own signals to their corresponding destinations via one of two relaying groups alternately every time phase. Each of the relaying groups has arbitrary number of relays, and each relay operates in half-duplex amplify-and-forward mode. In our scheme, the received signals at the relay nodes consist of desired signals and two different interference signals such as the inter-source interferences and the inter-group interferences which are caused by the phase incoherence of relaying. As such, we propose an iterative interference alignment algorithm to mitigate the interferences. We show that our proposed scheme achieves additional degrees of freedom compared to the conventional half-duplex relaying system in the interference relay channels. © 2013 IEEE.

  3. Induction of Associative Olfactory Memory by Targeted Activation of Single Olfactory Neurons in Drosophila Larvae

    OpenAIRE

    Honda, Takato; Lee, Chi-Yu; Yoshida-Kasikawa, Maki; Honjo, Ken; Furukubo-Tokunaga, Katsuo

    2014-01-01

    It has been postulated that associative memory is formed by at least two sets of external stimuli, CS and US, that are transmitted to the memory centers by distinctive conversing pathways. However, whether associative memory can be induced by the activation of only the olfactory CS and a biogenic amine-mediated US pathways remains to be elucidated. In this study, we substituted the reward signals with dTrpA1-mediated thermogenetic activation of octopaminergic neurons and the odor signals by C...

  4. Wireless Sensor Network Congestion Control Based on Standard Particle Swarm Optimization and Single Neuron PID

    Science.gov (United States)

    Yang, Xiaoping; Chen, Xueying; Xia, Riting; Qian, Zhihong

    2018-01-01

    Aiming at the problem of network congestion caused by the large number of data transmissions in wireless routing nodes of wireless sensor network (WSN), this paper puts forward an algorithm based on standard particle swarm–neural PID congestion control (PNPID). Firstly, PID control theory was applied to the queue management of wireless sensor nodes. Then, the self-learning and self-organizing ability of neurons was used to achieve online adjustment of weights to adjust the proportion, integral and differential parameters of the PID controller. Finally, the standard particle swarm optimization to neural PID (NPID) algorithm of initial values of proportion, integral and differential parameters and neuron learning rates were used for online optimization. This paper describes experiments and simulations which show that the PNPID algorithm effectively stabilized queue length near the expected value. At the same time, network performance, such as throughput and packet loss rate, was greatly improved, which alleviated network congestion and improved network QoS. PMID:29671822

  5. Bilayer Protograph Codes for Half-Duplex Relay Channels

    Science.gov (United States)

    Divsalar, Dariush; VanNguyen, Thuy; Nosratinia, Aria

    2013-01-01

    Direct to Earth return links are limited by the size and power of lander devices. A standard alternative is provided by a two-hops return link: a proximity link (from lander to orbiter relay) and a deep-space link (from orbiter relay to Earth). Although direct to Earth return links are limited by the size and power of lander devices, using an additional link and a proposed coding for relay channels, one can obtain a more reliable signal. Although significant progress has been made in the relay coding problem, existing codes must be painstakingly optimized to match to a single set of channel conditions, many of them do not offer easy encoding, and most of them do not have structured design. A high-performing LDPC (low-density parity-check) code for the relay channel addresses simultaneously two important issues: a code structure that allows low encoding complexity, and a flexible rate-compatible code that allows matching to various channel conditions. Most of the previous high-performance LDPC codes for the relay channel are tightly optimized for a given channel quality, and are not easily adapted without extensive re-optimization for various channel conditions. This code for the relay channel combines structured design and easy encoding with rate compatibility to allow adaptation to the three links involved in the relay channel, and furthermore offers very good performance. The proposed code is constructed by synthesizing a bilayer structure with a pro to graph. In addition to the contribution to relay encoding, an improved family of protograph codes was produced for the point-to-point AWGN (additive white Gaussian noise) channel whose high-rate members enjoy thresholds that are within 0.07 dB of capacity. These LDPC relay codes address three important issues in an integrative manner: low encoding complexity, modular structure allowing for easy design, and rate compatibility so that the code can be easily matched to a variety of channel conditions without extensive

  6. Energy efficient circuit design using nanoelectromechanical relays

    Science.gov (United States)

    Venkatasubramanian, Ramakrishnan

    Nano-electromechanical (NEM) relays are a promising class of emerging devices that offer zero off-state leakage and behave like an ideal switch. Recent advances in planar fabrication technology have demonstrated that microelectromechanical (MEMS) scale miniature relays could be manufactured reliably and could be used to build fully functional, complex integrated circuits. The zero leakage operation of relays has renewed the interest in relay based low power logic design. This dissertation explores circuit architectures using NEM relays and NEMS-CMOS heterogeneous integration. Novel circuit topologies for sequential logic, memory, and power management circuits have been proposed taking into consideration the NEM relay device properties and optimizing for energy efficiency and area. In nanoscale electromechanical devices, dispersion forces like Van der Waals' force (vdW) affect the pull-in stability of the relay devices significantly. Verilog-A electromechanical model of the suspended gate relay operating at 1V with a nominal air gap of 5 - 10nm has been developed taking into account all the electrical, mechanical and dispersion effects. This dissertation explores different relay based latch and flip-flop topologies. It has been shown that as few as 4 relay cells could be used to build flip-flops. An integrated voltage doubler based flip flop that improves the performance by 2X by overdriving Vgb has been proposed. Three NEM relay based parallel readout memory bitcell architectures have been proposed that have faster access time, and remove the reliability issues associated with previously reported serial readout architectures. A paradigm shift in design of power switches using NEM relays is proposed. An interesting property of the relay device is that the ON state resistance (Ron) of the NEM relay switch is constant and is insensitive to the gate slew rate. This coupled with infinite OFF state resistance (Roff ) offers significant area and power advantages over CMOS

  7. Switched diversity strategies for dual-hop relaying systems

    KAUST Repository

    Gaaloul, Fakhreddine

    2011-04-29

    This paper investigates the effect of different switched diversity configurations on the implementation complexity and achieved performance of dual-hop amplify-and-forward (AF) relaying networks. A low-complexity model of the relay station is adopted, wherein single-input single-output antenna configuration is employed. Each of the transmitter and the receiver however employs multiple antennas to improve the overall link performance. Single-phase and two-phase based receive switching strategies are investigated assuming optimum first hop signal-to-noise ratio (SNR). Moreover, the simple scheme in which the switched diversity is applied independently over the two hops is studied using tight upper bounds. Thorough performance comparisons and switching thresholds optimization for the aforementioned strategies are presented. Simulation results are also provided to validate the mathematical development and to verify the numerical computations.

  8. Simultaneous energy harvesting and information processing in wireless multiple relays with multiple antennas

    Science.gov (United States)

    Albaaj, Azhar; Makki, S. Vahab A.; Alabkhat, Qassem; Zahedi, Abdulhamid

    2017-07-01

    Wireless networks suffer from battery discharging specially in cooperative communications when multiple relays have an important role but they are energy constrained. To overcome this problem, energy harvesting from radio frequency signals is applied to charge the node battery. These intermediate nodes have the ability to harvest energy from the source signal and use the energy harvested to transmit information to the destination. In fact, the node tries to harvest energy and then transmit the data to destination. Division of energy harvesting and data transmission can be done in two algorithms: time-switching-based relaying protocol and power-splitting-based relaying protocol. These two algorithms also can be applied in delay-limited and delay-tolerant transmission systems. The previous works have assumed a single relay for energy harvesting, but in this article, the proposed method is concentrated on improving the outage probability and throughput by using multiple antennas in each relay node instead of using single antenna. According to our simulation results, when using multi-antenna relays, ability of energy harvesting is increased and thus system performance will be improved to great extent. Maximum ratio combining scheme has been used when the destination chooses the best signal of relays and antennas satisfying the required signal-to-noise ratio.

  9. Performance analysis of opportunistic nonregenerative relaying

    KAUST Repository

    Tourki, Kamel; Alouini, Mohamed-Slim; Qaraqe, Khalid A.; Yang, Hongchuan

    2013-01-01

    Opportunistic relaying in cooperative communication depends on careful relay selection. However, the traditional centralized method used for opportunistic amplify-and-forward protocols requires precise measurements of channel state information at the destination. In this paper, we adopt the max-min criterion as a relay selection framework for opportunistic amplify-and-forward cooperative communications, which was exhaustively used for the decode-and-forward protocol, and offer an accurate performance analysis based on exact statistics of the local signal-to-noise ratios of the best relay. Furthermore, we evaluate the asymptotical performance and deduce the diversity order of our proposed scheme. Finally, we validate our analysis by showing that performance simulation results coincide with our analytical results over Rayleigh fading channels, and we compare the max-min relay selection with their centralized channel state information-based and partial relay selection counterparts.

  10. Enhanced Peptide Detection Toward Single-Neuron Proteomics by Reversed-Phase Fractionation Capillary Electrophoresis Mass Spectrometry

    Science.gov (United States)

    Choi, Sam B.; Lombard-Banek, Camille; Muñoz-LLancao, Pablo; Manzini, M. Chiara; Nemes, Peter

    2018-05-01

    The ability to detect peptides and proteins in single cells is vital for understanding cell heterogeneity in the nervous system. Capillary electrophoresis (CE) nanoelectrospray ionization (nanoESI) provides high-resolution mass spectrometry (HRMS) with trace-level sensitivity, but compressed separation during CE challenges protein identification by tandem HRMS with limited MS/MS duty cycle. Here, we supplemented ultrasensitive CE-nanoESI-HRMS with reversed-phase (RP) fractionation to enhance identifications from protein digest amounts that approximate to a few mammalian neurons. An 1 to 20 μg neuronal protein digest was fractionated on a RP column (ZipTip), and 1 ng to 500 pg of peptides were analyzed by a custom-built CE-HRMS system. Compared with the control (no fractionation), RP fractionation improved CE separation (theoretical plates 274,000 versus 412,000 maximum, resp.), which enhanced detection sensitivity (2.5-fold higher signal-to-noise ratio), minimized co-isolation spectral interferences during MS/MS, and increased the temporal rate of peptide identification by up to 57%. From 1 ng of protein digest (organization. [Figure not available: see fulltext.

  11. On full duplex Gaussian relay channels with self-interference

    KAUST Repository

    Behboodi, Arash

    2016-08-15

    Self interference (SI) in full duplex (FD) systems is the interference caused by the transmission stream on the reception stream. Being one of the main restrictive factors for performance of practical full duplex systems, however, not too much is known about its effect on the fundamental limits of relaying systems. In this work, we consider the full duplex three-node relay channel with SI where SI is modeled as an additive Gaussian noise whose variance is dependent on instantaneous input power. The classical achievable rates and upper bounds for the single three-node relay channel no longer apply due to the structure of SI. Achievable rates for Decode-and-Forward (DF) and Compress-and-Forward (CF) and upper bounds on the capacity are derived assuming Gaussian inputs and SI. The deterministic model is also introduced and its capacity is characterized. The optimal joint source-relay distributions is discussed. Numerical results are provided comparing the achievable rates and upper bound. © 2016 IEEE.

  12. Study of GABAergic extra-synaptic tonic inhibition in single neurons and neural populations by traversing neural scales: application to propofol-induced anaesthesia.

    Science.gov (United States)

    Hutt, Axel; Buhry, Laure

    2014-12-01

    Anaesthetic agents are known to affect extra-synaptic GABAergic receptors, which induce tonic inhibitory currents. Since these receptors are very sensitive to small concentrations of agents, they are supposed to play an important role in the underlying neural mechanism of general anaesthesia. Moreover anaesthetic agents modulate the encephalographic activity (EEG) of subjects and hence show an effect on neural populations. To understand better the tonic inhibition effect in single neurons on neural populations and hence how it affects the EEG, the work considers single neurons and neural populations in a steady-state and studies numerically and analytically the modulation of their firing rate and nonlinear gain with respect to different levels of tonic inhibition. We consider populations of both type-I (Leaky Integrate-and-Fire model) and type-II (Morris-Lecar model) neurons. To bridge the single neuron description to the population description analytically, a recently proposed statistical approach is employed which allows to derive new analytical expressions for the population firing rate for type-I neurons. In addition, the work shows the derivation of a novel transfer function for type-I neurons as considered in neural mass models and studies briefly the interaction of synaptic and extra-synaptic inhibition. We reveal a strong subtractive and divisive effect of tonic inhibition in type-I neurons, i.e. a shift of the firing rate to higher excitation levels accompanied by a change of the nonlinear gain. Tonic inhibition shortens the excitation window of type-II neurons and their populations while maintaining the nonlinear gain. The gained results are interpreted in the context of recent experimental findings under propofol-induced anaesthesia.

  13. Relay Precoder Optimization in MIMO-Relay Networks With Imperfect CSI

    KAUST Repository

    Pandarakkottilil, Ubaidulla; Chockalingam, A.

    2011-01-01

    In this paper, we consider robust joint designs of relay precoder and destination receive filters in a nonregenerative multiple-input multiple-output (MIMO) relay network. The network consists of multiple source-destination node pairs assisted by a

  14. Alternate transmission with half-duplex relaying in MIMO interference relay networks

    KAUST Repository

    Park, Seongho; Ko, Youngchai; Park, Kihong; Alouini, Mohamed-Slim

    2013-01-01

    In this paper, we consider an alternate transmission scheme for a multiple-input multiple-output interference relay channel where multiple sources transmit their own signals to their corresponding destinations via one of two relaying groups

  15. Alternate transmission relaying based on interference alignment in 3-relay half-duplex MIMO systems

    KAUST Repository

    Park, Seongho; Park, Kihong; Ko, Youngchai; Alouini, Mohamed-Slim

    2012-01-01

    In a half-duplex relaying, the capacity pre-log factor 1/2 is a major drawback in spectral efficiency. This paper proposes a linear precoding/decoding scheme and an alternate relaying protocol in a dual-hop half-duplex system where three relays help the communication between the source and the destination. In our proposed scheme, we consider a phase incoherent method in relays in which the source alternately transmits message signals to the different relays. In addition, we propose a linear interference alignment scheme which can suppress the inter-relay interference resulting from the phase incoherence of relaying. Based on our analysis of degrees of freedom and our simulation results, we show that our proposed scheme achieves additional degrees of freedom compared to the conventional half-duplex relaying. © 2012 IEEE.

  16. Alternate transmission relaying based on interference alignment in 3-relay half-duplex MIMO systems

    KAUST Repository

    Park, Seongho

    2012-09-01

    In a half-duplex relaying, the capacity pre-log factor 1/2 is a major drawback in spectral efficiency. This paper proposes a linear precoding/decoding scheme and an alternate relaying protocol in a dual-hop half-duplex system where three relays help the communication between the source and the destination. In our proposed scheme, we consider a phase incoherent method in relays in which the source alternately transmits message signals to the different relays. In addition, we propose a linear interference alignment scheme which can suppress the inter-relay interference resulting from the phase incoherence of relaying. Based on our analysis of degrees of freedom and our simulation results, we show that our proposed scheme achieves additional degrees of freedom compared to the conventional half-duplex relaying. © 2012 IEEE.

  17. Electric equipment technical regulation on a relay

    International Nuclear Information System (INIS)

    1995-01-01

    It is about a relay for power protection. It describes the definitions of structure, a point of contact protection of contact, reclosing, relay scheme and input circuit. It explains normal use condition, special use condition, rated frequency, rated voltage and rated current, fluctuation range of permission of incoming relay. It deals with general structing outer case, correction device, operation indicator and outer terminal condition sort and method of the test. It adds the marks and pictures about currents

  18. Full-Duplex Relay Selection in Cognitive Underlay Networks

    KAUST Repository

    Khafagy, Mohammad Galal; Alouini, Mohamed-Slim; Aissa, Sonia

    2017-01-01

    In this work, we analyze the performance of full-duplex relay selection (FDRS) in spectrum-sharing networks. Contrary to half-duplex relaying, full-duplex relaying (FDR) enables simultaneous listening/forwarding at the secondary relay(s), thereby

  19. Relay self interference minimisation using tapped filter

    KAUST Repository

    Jazzar, Saleh

    2013-05-01

    In this paper we introduce a self interference (SI) estimation and minimisation technique for amplify and forward relays. Relays are used to help forward signals between a transmitter and a receiver. This helps increase the signal coverage and reduce the required transmitted signal power. One problem that faces relays communications is the leaked signal from the relay\\'s output to its input. This will cause an SI problem where the new received signal at the relay\\'s input will be added with the unwanted leaked signal from the relay\\'s output. A Solution is proposed in this paper to estimate and minimise this SI which is based upon using a tapped filter at the destination. To get the optimum weights for this tapped filter, some channel parameters must be estimated first. This is performed blindly at the destination without the need of any training. This channel parameter estimation method is named the blind-self-interference-channel-estimation (BSICE) method. The next step in the proposed solution is to estimate the tapped filter\\'s weights. This is performed by minimising the mean squared error (MSE) at the destination. This proposed method is named the MSE-Optimum Weight (MSE-OW) method. Simulation results are provided in this paper to verify the performance of BSICE and MSE-OW methods. © 2013 IEEE.

  20. Analysis of errors of radiation relay, (1)

    International Nuclear Information System (INIS)

    Koyanagi, Takami; Nakajima, Sinichi

    1976-01-01

    The statistical error of liquid level controlled by radiation relay is analysed and a method of minimizing the error is proposed. This method comes to the problem of optimum setting of the time constant of radiation relay. The equations for obtaining the value of time constant are presented and the numerical results are shown in a table and plotted in a figure. The optimum time constant of the upper level control relay is entirely different from that of the lower level control relay. (auth.)

  1. Multiuser Radio Resource Allocation for Multiservice Transmission in OFDMA-Based Cooperative Relay Networks

    Directory of Open Access Journals (Sweden)

    Zhang Xing

    2009-01-01

    Full Text Available Abstract The problem of multiservice transmission in OFDMA-based cooperative relay networks is studied comprehensively. We propose a framework to adaptively allocate power, subcarriers, and data rate in OFDMA system to maximize spectral efficiency under the constraints of satisfying multiuser multiservices' QoS requirements. Specifically, first we concentrate on the single-user scenario which considers multiservice transmission in point-to-point cooperative relay network. Based on the analysis of single-user scenario, we extend the multiservice transmission to multiuser point-to-multipoint scenario. Next, based on the framework, we propose several suboptimal radio resource allocation algorithms for multiservice transmissions in OFDMA-based cooperative relay networks to further reduce the computational complexity. Simulation results show that the proposed algorithms yield much higher spectral efficiency and much lower outage probability, which are flexible and efficient for the OFDMA-based cooperative relay system.

  2. Developmental profiles of the intrinsic properties and synaptic function of auditory neurons in preterm and term baboon neonates.

    Science.gov (United States)

    Kim, Sei Eun; Lee, Seul Yi; Blanco, Cynthia L; Kim, Jun Hee

    2014-08-20

    The human fetus starts to hear and undergoes major developmental changes in the auditory system during the third trimester of pregnancy. Although there are significant data regarding development of the auditory system in rodents, changes in intrinsic properties and synaptic function of auditory neurons in developing primate brain at hearing onset are poorly understood. We performed whole-cell patch-clamp recordings of principal neurons in the medial nucleus of trapezoid body (MNTB) in preterm and term baboon brainstem slices to study the structural and functional maturation of auditory synapses. Each MNTB principal neuron received an excitatory input from a single calyx of Held terminal, and this one-to-one pattern of innervation was already formed in preterm baboons delivered at 67% of normal gestation. There was no difference in frequency or amplitude of spontaneous excitatory postsynaptic synaptic currents between preterm and term MNTB neurons. In contrast, the frequency of spontaneous GABA(A)/glycine receptor-mediated inhibitory postsynaptic synaptic currents, which were prevalent in preterm MNTB neurons, was significantly reduced in term MNTB neurons. Preterm MNTB neurons had a higher input resistance than term neurons and fired in bursts, whereas term MNTB neurons fired a single action potential in response to suprathreshold current injection. The maturation of intrinsic properties and dominance of excitatory inputs in the primate MNTB allow it to take on its mature role as a fast and reliable relay synapse. Copyright © 2014 the authors 0270-6474/14/3411399-06$15.00/0.

  3. Single-trial estimation of stimulus and spike-history effects on time-varying ensemble spiking activity of multiple neurons: a simulation study

    International Nuclear Information System (INIS)

    Shimazaki, Hideaki

    2013-01-01

    Neurons in cortical circuits exhibit coordinated spiking activity, and can produce correlated synchronous spikes during behavior and cognition. We recently developed a method for estimating the dynamics of correlated ensemble activity by combining a model of simultaneous neuronal interactions (e.g., a spin-glass model) with a state-space method (Shimazaki et al. 2012 PLoS Comput Biol 8 e1002385). This method allows us to estimate stimulus-evoked dynamics of neuronal interactions which is reproducible in repeated trials under identical experimental conditions. However, the method may not be suitable for detecting stimulus responses if the neuronal dynamics exhibits significant variability across trials. In addition, the previous model does not include effects of past spiking activity of the neurons on the current state of ensemble activity. In this study, we develop a parametric method for simultaneously estimating the stimulus and spike-history effects on the ensemble activity from single-trial data even if the neurons exhibit dynamics that is largely unrelated to these effects. For this goal, we model ensemble neuronal activity as a latent process and include the stimulus and spike-history effects as exogenous inputs to the latent process. We develop an expectation-maximization algorithm that simultaneously achieves estimation of the latent process, stimulus responses, and spike-history effects. The proposed method is useful to analyze an interaction of internal cortical states and sensory evoked activity

  4. 78 FR 40407 - Structure and Practices of the Video Relay Service Program: Telecommunications Relay Services and...

    Science.gov (United States)

    2013-07-05

    ...] Structure and Practices of the Video Relay Service Program: Telecommunications Relay Services and Speech-to... telecommunications relay services (TRS) program continues to offer functional equivalence to all eligible users and..., identified by CG Docket Nos. 10-51 and 03-123, by any of the following methods: Electronic Filers: Comments...

  5. Protective relaying theory and applications

    CERN Document Server

    Elmore, Walter A

    2003-01-01

    Targeting the latest microprocessor technologies for more sophisticated applications in the field of power system short circuit detection, this revised and updated source imparts fundamental concepts and breakthrough science for the isolation of faulty equipment and minimization of damage in power system apparatus. The Second Edition clearly describes key procedures, devices, and elements crucial to the protection and control of power system function and stability. It includes chapters and expertise from the most knowledgeable experts in the field of protective relaying, and describes micropro

  6. Single Cell Electroporation Method for Mammalian CNS Neurons in Organotypic Slice Cultures

    Science.gov (United States)

    Uesaka, Naofumi; Hayano, Yasufumi; Yamada, Akito; Yamamoto, Nobuhiko

    Axon tracing is an essential technique to study the projection pattern of neurons in the CNS. Horse radish peroxidase and lectins have contributed to revealing many neural connection patterns in the CNS (Itaya and van Hoesen, 1982; Fabian and Coulter, 1985; Yoshihara, 2002). Moreover, a tracing method with fluorescent dye has enabled the observation of growing axons in living conditions, and demon strated a lot of developmental aspects in axon growth and guidance (Harris et al., 1987; O'Rourke and Fraser, 1990; Kaethner and Stuermer, 1992; Halloran and Kalil, 1994; Yamamoto et al., 1997). More recently, genetically encoded fluores cent proteins can be used as a powerful tool to observe various biological events. Several gene transfer techniques such as microinjection, biolistic gene gun, viral infection, lipofection and transgenic technology have been developed (Feng et al., 2000; Ehrengruber et al., 2001; O'Brien et al., 2001; Ma et al., 2002; Sahly et al., 2003). In particular, the electroporation technique was proved as a valuable tool, since it can be applied to a wide range of tissues and cell types with little toxicity and can be performed with relative technical easiness. Most methods, including a stand ard electroporation technique, are suitable for gene transfer to a large number of cells. However, this is not ideal for axonal tracing, because observation of individ ual axons is occasionally required. To overcome this problem, we have developed an electroporation method using glass micropipettes containing plasmid solutions and small current injection. Here we introduce the method in detail and exemplified results with some example applications and discuss its usefulness.

  7. An RSS based location estimation technique for cognitive relay networks

    KAUST Repository

    Qaraqe, Khalid A.; Hussain, Syed Imtiaz; Ç elebi, Hasari Burak; Abdallah, Mohamed M.; Alouini, Mohamed-Slim

    2010-01-01

    In this paper, a received signal strength (RSS) based location estimation method is proposed for a cooperative wireless relay network where the relay is a cognitive radio. We propose a method for the considered cognitive relay network to determine

  8. Error-rate performance analysis of opportunistic regenerative relaying

    KAUST Repository

    Tourki, Kamel; Yang, Hongchuan; Alouini, Mohamed-Slim

    2011-01-01

    In this paper, we investigate an opportunistic relaying scheme where the selected relay assists the source-destination (direct) communication. In our study, we consider a regenerative opportunistic relaying scheme in which the direct path can

  9. New results on performance analysis of opportunistic regenerative relaying

    KAUST Repository

    Tourki, Kamel; Yang, Hongchuan; Alouini, Mohamed-Slim; Qaraqe, Khalid A.

    2013-01-01

    In this paper, we investigate an opportunistic relaying scheme where the selected relay assists the source-destination (direct) communication. In our study, we consider a regenerative opportunistic relaying scheme in which the direct path may

  10. Accurate performance analysis of opportunistic decode-and-forward relaying

    KAUST Repository

    Tourki, Kamel; Yang, Hongchuan; Alouini, Mohamed-Slim

    2011-01-01

    In this paper, we investigate an opportunistic relaying scheme where the selected relay assists the source-destination (direct) communication. In our study, we consider a regenerative opportunistic relaying scheme in which the direct path may

  11. Opportunistic Relay Selection with Cooperative Macro Diversity

    Directory of Open Access Journals (Sweden)

    Yu Chia-Hao

    2010-01-01

    Full Text Available We apply a fully opportunistic relay selection scheme to study cooperative diversity in a semianalytical manner. In our framework, idle Mobile Stations (MSs are capable of being used as Relay Stations (RSs and no relaying is required if the direct path is strong. Our relay selection scheme is fully selection based: either the direct path or one of the relaying paths is selected. Macro diversity, which is often ignored in analytical works, is taken into account together with micro diversity by using a complete channel model that includes both shadow fading and fast fading effects. The stochastic geometry of the network is taken into account by having a random number of randomly located MSs. The outage probability analysis of the selection differs from the case where only fast fading is considered. Under our framework, distribution of the received power is formulated using different Channel State Information (CSI assumptions to simulate both optimistic and practical environments. The results show that the relay selection gain can be significant given a suitable amount of candidate RSs. Also, while relay selection according to incomplete CSI is diversity suboptimal compared to relay selection based on full CSI, the loss in average throughput is not too significant. This is a consequence of the dominance of geometry over fast fading.

  12. Microcomputer relay regulator in the CAMAC standard

    International Nuclear Information System (INIS)

    Nikolaev, V.P.

    1984-01-01

    The digital relay regulator is developed on the base of the KM001 microcomputer and KK06 controller for automatic control ob ects with transfer functions describing a broad class of systems using actuating motors (stabilitation, follow-up systems). The CAMAC relay-unit realizes the regulation law and provides the possibility to control analogous values by 8 channels

  13. Decode and Zero-Forcing Forward Relaying with Relay Selection in Cognitive Radio Systems

    KAUST Repository

    Park, Kihong

    2014-05-01

    In this paper, we investigate a cognitive radio (CR) relay network with multiple relay nodes that help forwarding the signal of CR users. Best relay selection is considered to take advantage of its low complexity of implementation. When the primary user (PU) is located close to the relay nodes, the performance of the secondary network is severely degraded due to the interference power constraint during the transmission in the second hop. We propose a decode and zero-forcing forward scheme to suppress the interference power at the relay nodes and analyze the statistics of the end-to-end signal-to-noise ratio when the relay nodes are located arbitrarily and experience therefore non-identical Rayleigh fading channels. Numerical results validate our theoretical results and show that our proposed scheme improves the performance of the CR network when the PU is close to the relay nodes. © 2014 IEEE.

  14. On the achievable degrees of freedom of alternate MIMO relaying with multiple AF relays

    KAUST Repository

    Park, Kihong

    2012-03-01

    In this paper, we consider a two-hop relaying network where one source, one destination, and multiple amplify-and-forward (AF) relays equipped with M antennas operate in a half-duplex mode. In order to compensate for the inherent loss of capacity pre-log factor of 1/2 due to half-duplex relaying, we propose a new transmission protocol which combines alternate relaying and inter-relay interference alignment. We prove that the proposed scheme can (i) exploits M degrees of freedom (DOFs) and (ii) perfectly recover the pre-log factor loss if the number of relays is at least six. From our selected numerical results, we show that our proposed scheme gives significant improvement over conventional AF relaying which offers only M/2 DOFs. © 2012 IEEE.

  15. Bilayer expurgated LDPC codes with uncoded relaying

    Directory of Open Access Journals (Sweden)

    Md. Noor-A-Rahim

    2017-08-01

    Full Text Available Bilayer low-density parity-check (LDPC codes are an effective coding technique for decode-and-forward relaying, where the relay forwards extra parity bits to help the destination to decode the source bits correctly. In the existing bilayer coding scheme, these parity bits are protected by an error correcting code and assumed reliably available at the receiver. We propose an uncoded relaying scheme, where the extra parity bits are forwarded to the destination without any protection. Through density evolution analysis and simulation results, we show that our proposed scheme achieves better performance in terms of bit erasure probability than the existing relaying scheme. In addition, our proposed scheme results in lower complexity at the relay.

  16. On Alternate Relaying with Improper Gaussian Signaling

    KAUST Repository

    Gaafar, Mohamed

    2016-06-06

    In this letter, we investigate the potential benefits of adopting improper Gaussian signaling (IGS) in a two-hop alternate relaying (AR) system. Given the known benefits of using IGS in interference-limited networks, we propose to use IGS to relieve the inter-relay interference (IRI) impact on the AR system assuming no channel state information is available at the source. In this regard, we assume that the two relays use IGS and the source uses proper Gaussian signaling (PGS). Then, we optimize the degree of impropriety of the relays signal, measured by the circularity coefficient, to maximize the total achievable rate. Simulation results show that using IGS yields a significant performance improvement over PGS, especially when the first hop is a bottleneck due to weak source-relay channel gains and/or strong IRI.

  17. On Alternate Relaying with Improper Gaussian Signaling

    KAUST Repository

    Gaafar, Mohamed; Amin, Osama; Ikhlef, Aissa; Chaaban, Anas; Alouini, Mohamed-Slim

    2016-01-01

    In this letter, we investigate the potential benefits of adopting improper Gaussian signaling (IGS) in a two-hop alternate relaying (AR) system. Given the known benefits of using IGS in interference-limited networks, we propose to use IGS to relieve the inter-relay interference (IRI) impact on the AR system assuming no channel state information is available at the source. In this regard, we assume that the two relays use IGS and the source uses proper Gaussian signaling (PGS). Then, we optimize the degree of impropriety of the relays signal, measured by the circularity coefficient, to maximize the total achievable rate. Simulation results show that using IGS yields a significant performance improvement over PGS, especially when the first hop is a bottleneck due to weak source-relay channel gains and/or strong IRI.

  18. The Impact of TCSC on IDMT Relays in SLG Fault in Distribution Networks

    Directory of Open Access Journals (Sweden)

    Lazhar Bougouffa

    2016-03-01

    Full Text Available IDMT Directional Over-Current Relays protection is one of the basic protective relaying for distribution systems, for fault detection and clearing as soon as possible. Its function would generally be changed in presence of FACTS devices. In this paper a study to investigate the direct effect of varying reactance of the TCSC on single-line-to-ground (SLG fault in compensated distribution systems. This paper, therefore presents the calculation of fault component, and directional over-current relay operating time characteristics for phase-to-earth fault involving the TCSC. The case study is compared between compensated and uncompensated system. The coordination of the relays is a nonlinear programming problem and it is solved by using MATLAB software.

  19. Design and Implementation of O/C relay using Microprocessor

    Directory of Open Access Journals (Sweden)

    Dr.Abdul-Sattar H. Jasim

    2012-03-01

    Full Text Available This work presents the design and implementation of a versatile digital overcurrent (O/C relay using a single microprocessor. The relay is implemented by a combination of a look-up table and a counter. The software development and hardware testing are done using a microcomputer module based on a 8-bit microprocessor. The digital processing of measured currents enables a separate setting of operating values selection of all types of inverse or constant time characteristics overcurrent protection. This protection provides reasonably fast tripping, even at terminal close to the power source were the most serve faults can occur excluding the transient condition. So this method has an excellent compromise between accuracy hardware and speed

  20. Neuronal thresholds and choice-related activity of otolith afferent fibers during heading perception.

    Science.gov (United States)

    Yu, Xiong-jie; Dickman, J David; DeAngelis, Gregory C; Angelaki, Dora E

    2015-05-19

    How activity of sensory neurons leads to perceptual decisions remains a challenge to understand. Correlations between choices and single neuron firing rates have been found early in vestibular processing, in the brainstem and cerebellum. To investigate the origins of choice-related activity, we have recorded from otolith afferent fibers while animals performed a fine heading discrimination task. We find that afferent fibers have similar discrimination thresholds as central cells, and the most sensitive fibers have thresholds that are only twofold or threefold greater than perceptual thresholds. Unlike brainstem and cerebellar nuclei neurons, spike counts from afferent fibers do not exhibit trial-by-trial correlations with perceptual decisions. This finding may reflect the fact that otolith afferent responses are poorly suited for driving heading perception because they fail to discriminate self-motion from changes in orientation relative to gravity. Alternatively, if choice probabilities reflect top-down inference signals, they are not relayed to the vestibular periphery.

  1. Attractor dynamics in local neuronal networks

    Directory of Open Access Journals (Sweden)

    Jean-Philippe eThivierge

    2014-03-01

    Full Text Available Patterns of synaptic connectivity in various regions of the brain are characterized by the presence of synaptic motifs, defined as unidirectional and bidirectional synaptic contacts that follow a particular configuration and link together small groups of neurons. Recent computational work proposes that a relay network (two populations communicating via a third, relay population of neurons can generate precise patterns of neural synchronization. Here, we employ two distinct models of neuronal dynamics and show that simulated neural circuits designed in this way are caught in a global attractor of activity that prevents neurons from modulating their response on the basis of incoming stimuli. To circumvent the emergence of a fixed global attractor, we propose a mechanism of selective gain inhibition that promotes flexible responses to external stimuli. We suggest that local neuronal circuits may employ this mechanism to generate precise patterns of neural synchronization whose transient nature delimits the occurrence of a brief stimulus.

  2. Mapping of odor-related neuronal activity in the olfactory bulb by high-resolution 2-deoxyglucose autoradiography

    International Nuclear Information System (INIS)

    Lancet, D.; Greer, C.A.; Kauer, J.S.; Shepherd, G.M.

    1982-01-01

    The spatial distribution of odor-induced neuronal activity in the olfactory bulb, the first relay station of the olfactory pathway, is believed to reflect important aspects of chemosensory coding. We report here the application of high-resolution 2-deoxyglucose autoradiography to the mapping of spatial patterns of metabolic activity at the level of single neurons in the olfactory bulb. It was found that glomeruli, which are synaptic complexes containing the first synaptic relay, tend to be uniformly active or inactive during odor exposure. Differential 2-deoxyglucose uptake was also observed in the somata of projection neurons (mitral cells) and interneurons (periglomerular and granule cells). This confirms and extends our previous studies in which odor-specific laminar and focal uptake patterns were revealed by the conventional x-ray film 2-deoxyglucose method due to Sokoloff and colleagues [Sokoloff, L., Reivich, M., Kennedy, C., DesRosiers, M. H., Patlak, C. S., Pettigrew, K. D., Sakurada, O. and Shinohara, M. (1977) J. Neurochem. 28, 897-916]. Based on results obtained by the two methods, it is suggested that the glomerulus as a whole serves as a functional unit of activity. The high-resolution results are interpreted in terms of the well-characterized synaptic organization of the olfactory bulb and also serve to illustrate the capability of the 2-deoxyglucose autoradiographic technique to map metabolic activity in single neurons of the vertebrate central nervous system

  3. Security-Reliability Trade-Off Analysis for Multiuser SIMO Mixed RF/FSO Relay Networks With Opportunistic User Scheduling

    KAUST Repository

    El-Malek, Ahmed H. Abd; Salhab, Anas M.; Zummo, Salam A.; Alouini, Mohamed-Slim

    2016-01-01

    In this paper, we study the performance of multiuser single-input multiple-output mixed radio frequency (RF)/free space optical (FSO) relay network with opportunistic user scheduling. The considered system includes multiple users, one amplify

  4. Enhancing Physical Layer Security of Multiuser SIMO Mixed RF/FSO Relay Networks with Multi-Eavesdroppers

    KAUST Repository

    El-Malek, Ahmed H. Abd; Salhab, Anas M.; Zummo, Salam A.; Alouini, Mohamed-Slim

    2017-01-01

    In this paper, we investigate the secrecy performance of multiuser (MU) single-input multiple-output (SIMO) mixed radio frequency (RF)/free space optical (FSO) relay network with opportunistic user scheduling and multiple eavesdropping attacks

  5. Sequential estimation of intrinsic activity and synaptic input in single neurons by particle filtering with optimal importance density

    Science.gov (United States)

    Closas, Pau; Guillamon, Antoni

    2017-12-01

    This paper deals with the problem of inferring the signals and parameters that cause neural activity to occur. The ultimate challenge being to unveil brain's connectivity, here we focus on a microscopic vision of the problem, where single neurons (potentially connected to a network of peers) are at the core of our study. The sole observation available are noisy, sampled voltage traces obtained from intracellular recordings. We design algorithms and inference methods using the tools provided by stochastic filtering that allow a probabilistic interpretation and treatment of the problem. Using particle filtering, we are able to reconstruct traces of voltages and estimate the time course of auxiliary variables. By extending the algorithm, through PMCMC methodology, we are able to estimate hidden physiological parameters as well, like intrinsic conductances or reversal potentials. Last, but not least, the method is applied to estimate synaptic conductances arriving at a target cell, thus reconstructing the synaptic excitatory/inhibitory input traces. Notably, the performance of these estimations achieve the theoretical lower bounds even in spiking regimes.

  6. Emphasis of spatial cues in the temporal fine structure during the rising segments of amplitude-modulated sounds II: single-neuron recordings

    Science.gov (United States)

    Marquardt, Torsten; Stange, Annette; Pecka, Michael; Grothe, Benedikt; McAlpine, David

    2014-01-01

    Recently, with the use of an amplitude-modulated binaural beat (AMBB), in which sound amplitude and interaural-phase difference (IPD) were modulated with a fixed mutual relationship (Dietz et al. 2013b), we demonstrated that the human auditory system uses interaural timing differences in the temporal fine structure of modulated sounds only during the rising portion of each modulation cycle. However, the degree to which peripheral or central mechanisms contribute to the observed strong dominance of the rising slope remains to be determined. Here, by recording responses of single neurons in the medial superior olive (MSO) of anesthetized gerbils and in the inferior colliculus (IC) of anesthetized guinea pigs to AMBBs, we report a correlation between the position within the amplitude-modulation (AM) cycle generating the maximum response rate and the position at which the instantaneous IPD dominates the total neural response. The IPD during the rising segment dominates the total response in 78% of MSO neurons and 69% of IC neurons, with responses of the remaining neurons predominantly coding the IPD around the modulation maximum. The observed diversity of dominance regions within the AM cycle, especially in the IC, and its comparison with the human behavioral data suggest that only the subpopulation of neurons with rising slope dominance codes the sound-source location in complex listening conditions. A comparison of two models to account for the data suggests that emphasis on IPDs during the rising slope of the AM cycle depends on adaptation processes occurring before binaural interaction. PMID:24554782

  7. Application of a proposed overcurrent relay in radial distribution networks

    Energy Technology Data Exchange (ETDEWEB)

    Conde, A.; Vazquez, E. [Universidad Autonoma de Nuevo Leon, Facultad de Ingenieria Mecanica y Electrica, A.P. 36-F, CU, CP 66450, San Nicolas de los Garza, Nuevo Leon (Mexico)

    2011-02-15

    This paper contains the application criteria and coordination process for a proposed overcurrent relay in a radial power system with feed from one or multiple sources. This relay uses independent functions to detect faults and to calculate the operation time. Also this relay uses a time element function that allows it to reduce the time relay operation, enhancing the backup protection. Some of the proposed approaches improve the sensitivity of the relay. The selection of the best approach in the proposed relay is defined by the needs of the application. The proposed protection can be considered as an additional function protection to conventional overcurrent relays. (author)

  8. Time of arrival based location estimation for cooperative relay networks

    KAUST Repository

    Çelebi, Hasari Burak

    2010-09-01

    In this paper, we investigate the performance of a cooperative relay network performing location estimation through time of arrival (TOA). We derive Cramer-Rao lower bound (CRLB) for the location estimates using the relay network. The analysis is extended to obtain average CRLB considering the signal fluctuations in both relay and direct links. The effects of the channel fading of both relay and direct links and amplification factor and location of the relay node on average CRLB are investigated. Simulation results show that the channel fading of both relay and direct links and amplification factor and location of relay node affect the accuracy of TOA based location estimation. ©2010 IEEE.

  9. Time of arrival based location estimation for cooperative relay networks

    KAUST Repository

    Ç elebi, Hasari Burak; Abdallah, Mohamed M.; Hussain, Syed Imtiaz; Qaraqe, Khalid A.; Alouini, Mohamed-Slim

    2010-01-01

    In this paper, we investigate the performance of a cooperative relay network performing location estimation through time of arrival (TOA). We derive Cramer-Rao lower bound (CRLB) for the location estimates using the relay network. The analysis is extended to obtain average CRLB considering the signal fluctuations in both relay and direct links. The effects of the channel fading of both relay and direct links and amplification factor and location of the relay node on average CRLB are investigated. Simulation results show that the channel fading of both relay and direct links and amplification factor and location of relay node affect the accuracy of TOA based location estimation. ©2010 IEEE.

  10. Cognitive relaying and power allocation under channel state uncertainties

    KAUST Repository

    Pandarakkottilil, Ubaidulla

    2013-04-01

    In this paper, we present robust joint relay precoder designs and transceiver power allocations for a cognitive radio network under imperfect channel state information (CSI). The secondary (or cognitive) network consists of a pair of single-antenna transceiver nodes and a non-regenerative two-way relay with multiple antennas which aids the communication process between the transceiver pair. The secondary nodes share the spectrum with a licensed primary user (PU) while guaranteeing that the interference to the PU receiver is maintained below a specified threshold. We consider two robust designs: the first is based on the minimization of the total transmit power of the secondary relay node required to provide the minimum quality of service, measured in terms of mean-square error (MSE) of the transceiver nodes, and the second is based on the minimization of the sum-MSE of the transceiver nodes. The robust designs are based on worst-case optimization and take into account known parameters of the error in the CSI to render the performance immune to the presence of errors in the CSI. Though the original problem is non-convex, we show that the proposed designs can be reformulated as tractable convex optimization problems that can be solved efficiently. We illustrate the performance of the proposed designs through some selected numerical simulations. © 2013 IEEE.

  11. Minimax robust relay selection based on uncertain long-term CSI

    KAUST Repository

    Nisar, Muhammad Danish

    2014-02-01

    Cooperative communications via multiple relay nodes is known to provide the benefits of increase diversity and coverage. Simultaneous transmission via multiple relays, however, requires strong coordination between nodes either in terms of slot-based transmission or distributed space-time (ST) code implementation. Dynamically selecting a single best relay out of multiple relays and then using it alone for cooperative transmission alleviates the need for this strong coordination while still reaping the benefits of increased diversity and coverage. In this paper, we consider the design of relay selection (RS) under an imperfect knowledge of long-term channel state information (CSI) at the relay nodes, and we pursue minimax optimization to arrive at a robust RS approach that promises the best guarantee on the worst-case end-to-end signal-to-noise ratio (SNR). We provide some intuitive examples and extensive simulation results, not only in terms of worst-case SNR performance but also in terms of average bit-error-rate (BER) performance, to demonstrate the benefits of the proposed minimax robust RS scheme. © 2013 IEEE.

  12. Distributed cognitive two-way relay beamformer designs under perfect and imperfect CSI

    KAUST Repository

    Pandarakkottilil, Ubaidulla

    2011-09-01

    In this paper, we present distributed two-way relay beamformer designs for a cognitive radio network (CRN) in which a pair of cognitive (or secondary) transceiver nodes communicate with each other assisted by a set of cognitive two-way relay nodes. The secondary nodes share the spectrum with a licensed primary user (PU) node, and each node is assumed to be equipped with a single transmit/receive antenna. The interference to the PU resulting from the transmission from the cognitive nodes is kept below a specified limit. First, we consider relay beamformer designs assuming the availability of perfect channel state information (CSI). For this case, a mean-square error (MSE)-constrained beamformer that minimizes the total relay transmit power, and an MSE-balancing beamformer with a constraint on the total relay transmit power are proposed. Next, we consider relay beamformer designs assuming that the available CSI is imperfect. For this case too, we consider the same problems as those in the case of perfect CSI, and propose beamformer designs that are robust to the errors in the CSI. We show that the proposed designs can be reformulated as convex optimization problems that can be solved efficiently. Through numerical simulations, we illustrate the performance of the proposed designs. © 2011 IEEE.

  13. Distributed Antenna Channels with Regenerative Relaying: Relay Selection and Asymptotic Capacity

    Directory of Open Access Journals (Sweden)

    Aitor del Coso

    2007-11-01

    Full Text Available Multiple-input-multiple-output (MIMO techniques have been widely proposed as a means to improve capacity and reliability of wireless channels, and have become the most promising technology for next generation networks. However, their practical deployment in current wireless devices is severely affected by antenna correlation, which reduces their impact on performance. One approach to solve this limitation is relaying diversity. In relay channels, a set of N wireless nodes aids a source-destination communication by relaying the source data, thus creating a distributed antenna array with uncorrelated path gains. In this paper, we study this multiple relay channel (MRC following a decode-and-forward (D&F strategy (i.e., regenerative forwarding, and derive its achievable rate under AWGN. A half-duplex constraint on relays is assumed, as well as distributed channel knowledge at both transmitter and receiver sides of the communication. For this channel, we obtain the optimum relay selection algorithm and the optimum power allocation within the network so that the transmission rate is maximized. Likewise, we bound the ergodic performance of the achievable rate and derive its asymptotic behavior in the number of relays. Results show that the achievable rate of regenerative MRC grows as the logarithm of the Lambert W function of the total number of relays, that is, 𝒞=log⁡2(W0(N. Therefore, D&F relaying, cannot achieve the capacity of actual MISO channels.

  14. Partial relay selection in underlay cognitive networks with fixed gain relays

    KAUST Repository

    Hussain, Syed Imtiaz; Alouini, Mohamed-Slim; Hasna, Mazen Omar; Qaraqe, Khalid A.

    2012-01-01

    In a communication system with multiple cooperative relays, selecting the best relay utilizes the available spectrum more efficiently. However, selective relaying poses a different problem in underlay cognitive networks compared to the traditional cooperative networks due to interference thresholds to the primary users. In most cases, a best relay is the one which provides the maximum end-to-end signal to noise ratio (SNR). This approach needs plenty of instantaneous channel state information (CSI). The CSI burden could be reduced by partial relay selection. In this paper, a partial relay selection scheme is presented and analyzed for an underlay cognitive network with fixed gain relays operating in the vicinity of a primary user. The system model is adopted in a way that each node needs minimal CSI to perform its task. The best relay is chosen on the basis of maximum source to relay link SNR which then forwards the message to the destination. We derive closed form expressions for the received SNR distributions, system outage, probability of bit error and average channel capacity of the system. The derived results are confirmed through simulations. © 2012 IEEE.

  15. Partial relay selection in underlay cognitive networks with fixed gain relays

    KAUST Repository

    Hussain, Syed Imtiaz

    2012-05-01

    In a communication system with multiple cooperative relays, selecting the best relay utilizes the available spectrum more efficiently. However, selective relaying poses a different problem in underlay cognitive networks compared to the traditional cooperative networks due to interference thresholds to the primary users. In most cases, a best relay is the one which provides the maximum end-to-end signal to noise ratio (SNR). This approach needs plenty of instantaneous channel state information (CSI). The CSI burden could be reduced by partial relay selection. In this paper, a partial relay selection scheme is presented and analyzed for an underlay cognitive network with fixed gain relays operating in the vicinity of a primary user. The system model is adopted in a way that each node needs minimal CSI to perform its task. The best relay is chosen on the basis of maximum source to relay link SNR which then forwards the message to the destination. We derive closed form expressions for the received SNR distributions, system outage, probability of bit error and average channel capacity of the system. The derived results are confirmed through simulations. © 2012 IEEE.

  16. One nuclear calcium transient induced by a single burst of action potentials represents the minimum signal strength in activity-dependent transcription in hippocampal neurons.

    Science.gov (United States)

    Yu, Yan; Oberlaender, Kristin; Bengtson, C Peter; Bading, Hilmar

    2017-07-01

    Neurons undergo dramatic changes in their gene expression profiles in response to synaptic stimulation. The coupling of neuronal excitation to gene transcription is well studied and is mediated by signaling pathways activated by cytoplasmic and nuclear calcium transients. Despite this, the minimum synaptic activity required to induce gene expression remains unknown. To address this, we used cultured hippocampal neurons and cellular compartment analysis of temporal activity by fluorescence in situ hybridization (catFISH) that allows detection of nascent transcripts in the cell nucleus. We found that a single burst of action potentials, consisting of 24.4±5.1 action potentials during a 6.7±1.9s depolarization of 19.5±2.0mV causing a 9.3±0.9s somatic calcium transient, is sufficient to activate transcription of the immediate early gene arc (also known as Arg3.1). The total arc mRNA yield produced after a single burst-induced nuclear calcium transient was very small and, compared to unstimulated control neurons, did not lead to a significant increase in arc mRNA levels measured using quantitative reverse transcriptase PCR (qRT-PCR) of cell lysates. Significantly increased arc mRNA levels became detectable in hippocampal neurons that had undergone 5-8 consecutive burst-induced nuclear calcium transients at 0.05-0.15Hz. These results indicate that a single burst-induced nuclear calcium transient can activate gene expression and that transcription is rapidly shut off after synaptic stimulation has ceased. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. LTE-Advanced Relay Technology and Standardization

    CERN Document Server

    Yuan, Yifei

    2013-01-01

    LTE-Advanced Relay Technology and Standardization provides a timely reference work for relay technology with the finalizing of LTE Release 10 specifications. LTE-Advanced is quickly becoming the global standard for 4G cellular communications. The relay technology, as one of the key features in LTE-Advanced, helps not only to improve the system coverage and capacity, but also to save the costs of laying wireline backhaul. As a leading researcher in the field of LTE-Advanced standards, the author provides an in-depth description of LTE-A relay technology, and explains in detail the standard specification and design principles.     Readers from both academic and industrial fields can find sections of interest to them: Sections 2 & 4 could benefit researchers in academia and those who are engaged in exploratory work, while Sections 3 & 4 are more useful to engineers. Dr. Yifei Yuan is the Technical Director at the Standards Department of ZTE Inc.

  18. Reversal thyristor-relay direct current commutator

    International Nuclear Information System (INIS)

    Ivanenko, A.I.

    1982-01-01

    A thyristor-relay commutator used for alteration of the leading magnetic field direction in experiments with polarized neutrons is described. The commutator flowsheet is presented. Thyristors, connected so as to allow the relay trigger operation mode, are used as controllable electronic relay. Two connected in series coils with the total inductance of the order of 0.28 H serve as the electronic relay load. The arc-free current commutation is effected at the moment of the minimal current across the load terminals, which allows to easily reverse the current up to 10 A at a volatage, v <= 150 V. The experience gained within a year of operation has shown that the commutator meets the requirements of reliability and tuning

  19. Developing a Domain Model for Relay Circuits

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth

    2009-01-01

    In this paper we stepwise develop a domain model for relay circuits as used in railway control systems. First we provide an abstract, property-oriented model of networks consisting of components that can be glued together with connectors. This model is strongly inspired by a network model...... for railways madeby Bjørner et.al., however our model is more general: the components can be of any kind and can later be refined to e.g. railway components or circuit components. Then we show how the abstract network model can be refined into an explicit model for relay circuits. The circuit model describes...... the statics as well as the dynamics of relay circuits, i.e. how a relay circuit can be composed legally from electrical components as well as how the components may change state over time. Finally the circuit model is transformed into an executable model, and we show how a concrete circuit can be defined...

  20. Evaluation of Harmonics Impact on Digital Relays

    Directory of Open Access Journals (Sweden)

    Kinan Wannous

    2018-04-01

    Full Text Available This paper presents the concept of the impact of harmonic distortion on a digital protection relay. The aim is to verify and determine the reasons of a mal-trip or failure to trip the protection relays; the suggested solution of the harmonic distortion is explained by a mathematical model in the Matlab Simulink programming environment. The digital relays have been tested under harmonic distortions in order to verify the function of the relays algorithm under abnormal conditions. The comparison between the protection relay algorithm under abnormal conditions and a mathematical model in the Matlab Simulink programming environment based on injected harmonics of high values is provided. The test is separated into different levels; the first level is based on the harmonic effect of an individual harmonic and mixed harmonics. The test includes the effect of the harmonics in the location of the fault point into distance protection zones. This paper is a new proposal in the signal processing of power quality disturbances using Matlab Simulink and the power quality impact on the measurements of the power system quantities; the test simulates the function of protection in power systems in terms of calculating the current and voltage values of short circuits and their faults. The paper includes several tests: frequency variations and decomposition of voltage waveforms with Fourier transforms (model and commercial relay, the effect of the power factor on the location of fault points, the relation between the tripping time and the total harmonic distortion (THD levels in a commercial relay, and a comparison of the THD capture between the commercial relay and the model.

  1. Relay selection from an effective capacity perspective

    KAUST Repository

    Yang, Yuli

    2013-09-01

    In this work, we consider a cooperative network where multiple relay nodes having different modulation capabilities assist the end-to-end communication between a source and its destination. Firstly, we evaluate the effective capacity (EC) performance of the network under study. According to the analysis, an EC-based relay selection criterion is proposed. Based on the proposed selection rule and half-duplex decode-and-forward protocol, the activated relays cooperatively help with the packet transmission from the source. At the destination, packet combining is taken into account to improve the quality of service. Compared to the popular scheme, opportunistic relay selection, numerical results are provided to prove the validity and advantages of our proposed scheme in certain scenarios. Moreover, the analysis presented herein offers a convenient tool to the relaying transmission design, specifically on which relay selection scheme should be used as well as how to choose the receiving strategy between with and without packet combining at the destination. © 2013 IEEE.

  2. Airborne relay-based regional positioning system.

    Science.gov (United States)

    Lee, Kyuman; Noh, Hongjun; Lim, Jaesung

    2015-05-28

    Ground-based pseudolite systems have some limitations, such as low vertical accuracy, multipath effects and near-far problems. These problems are not significant in airborne-based pseudolite systems. However, the monitoring of pseudolite positions is required because of the mobility of the platforms on which the pseudolites are mounted, and this causes performance degradation. To address these pseudolite system limitations, we propose an airborne relay-based regional positioning system that consists of a master station, reference stations, airborne relays and a user. In the proposed system, navigation signals are generated from the reference stations located on the ground and are relayed via the airborne relays. Unlike in conventional airborne-based systems, the user in the proposed system sequentially estimates both the locations of airborne relays and his/her own position. Therefore, a delay due to monitoring does not occur, and the accuracy is not affected by the movement of airborne relays. We conducted several simulations to evaluate the performance of the proposed system. Based on the simulation results, we demonstrated that the proposed system guarantees a higher accuracy than airborne-based pseudolite systems, and it is feasible despite the existence of clock offsets among reference stations.

  3. Relay Runners Catch The Rays

    CERN Multimedia

    2004-01-01

    Athletes sizzled around CERN on Wednesday 19 May at the 34th annual relay race. On one of the warmest days of the year so far, sunkissed competitors ran for the finish line and then straight for the drinks table. The Shabbys were on fire again, hurtling across the line first in a time of 10 min. 42.6 sec. and making an even stronger claim to being hailed as the traditional winners of the race with their fourth triumph in a row. Also on form were the Lynx Runners who won the Veteran's trophy, continuing their winning ways since 2002 and placing 29th overall. Ildefons Magrans of the ALICE Quarks on the Loose team ran the fastest 1000m in a time of 2 min. 47 sec. Second-placed Charmilles Technologies won the Open category in a time of 11 min. 03 sec., taking the prize for teams whose members work in different departments or who come from outside CERN. The OPALadies won the women's trophy and placed 48th. With 9 trophies up for grabs, more than 300 people in 55 teams ran the fun run, covering distances of 1000m ...

  4. Physical Layer Security Using Two-Path Successive Relaying

    Directory of Open Access Journals (Sweden)

    Qian Yu Liau

    2016-06-01

    Full Text Available Relaying is one of the useful techniques to enhance wireless physical-layer security. Existing literature shows that employing full-duplex relay instead of conventional half-duplex relay improves secrecy capacity and secrecy outage probability, but this is at the price of sophisticated implementation. As an alternative, two-path successive relaying has been proposed to emulate operation of full-duplex relay by scheduling a pair of half-duplex relays to assist the source transmission alternately. However, the performance of two-path successive relaying in secrecy communication remains unexplored. This paper proposes a secrecy two-path successive relaying protocol for a scenario with one source, one destination and two half-duplex relays. The relays operate alternately in a time division mode to forward messages continuously from source to destination in the presence of an eavesdropper. Analytical results reveal that the use of two half-duplex relays in the proposed scheme contributes towards a quadratically lower probability of interception compared to full-duplex relaying. Numerical simulations show that the proposed protocol achieves the ergodic achievable secrecy rate of full-duplex relaying while delivering the lowest probability of interception and secrecy outage probability compared to the existing half duplex relaying, full duplex relaying and full duplex jamming schemes.

  5. Single whole-body exposure to sarin vapor in rats: Long-term neuronal and behavioral deficits

    International Nuclear Information System (INIS)

    Grauer, Ettie; Chapman, Shira; Rabinovitz, Ishai; Raveh, Lily; Weissman, Ben-Avi; Kadar, Tamar; Allon, Nahum

    2008-01-01

    Freely moving rats were exposed to sarin vapor (34.2 ± 0.8 μg/l) for 10 min. Mortality at 24 h was 35% and toxic sings in the surviving rats ranged from sever (prolonged convulsions) through moderate to almost no overt signs. Some of the surviving rats developed delayed, intermittent convulsions. All rats were evaluated for long-term functional deficits in comparison to air-exposed control rats. Histological analysis revealed typical cell loss at 1 week post inhalation exposure. Neuronal inflammation was demonstrated by a 20-fold increase in prostaglandin (PGE 2 ) levels 24 h following exposure that markedly decreased 6 days later. An additional, delayed increase in PGE 2 was detected at 1 month and continued to increase for up to 6 months post exposure. Glial activation following neural damage was demonstrated by an elevated level of peripheral benzodiazepine receptors (PBR) seen in the brain 4 and 6 months after exposure. At the same time muscarinic receptors were unaffected. Six weeks, four and six months post exposure behavioral evaluations were performed. In the open field, sarin-exposed rats showed a significant increase in overall activity with no habituation over days. In a working memory paradigm in the water maze, these same rats showed impaired working and reference memory processes with no recovery. Our data suggest long lasting impairment of brain functions in surviving rats following a single sarin exposure. Animals that seem to fully recover from the exposure, and even animals that initially show no toxicity signs, developed some adverse neural changes with time

  6. Optimal relay selection and power allocation for cognitive two-way relaying networks

    KAUST Repository

    Pandarakkottilil, Ubaidulla; Aï ssa, Sonia

    2012-01-01

    In this paper, we present an optimal scheme for power allocation and relay selection in a cognitive radio network where a pair of cognitive (or secondary) transceiver nodes communicate with each other assisted by a set of cognitive two-way relays

  7. On the achievable degrees of freedom of alternate MIMO relaying with multiple AF relays

    KAUST Repository

    Park, Kihong; Alouini, Mohamed-Slim; Park, Seongho; Ko, Youngchai

    2012-01-01

    In this paper, we consider a two-hop relaying network where one source, one destination, and multiple amplify-and-forward (AF) relays equipped with M antennas operate in a half-duplex mode. In order to compensate for the inherent loss of capacity

  8. Reactive relay selection in underlay cognitive networks with fixed gain relays

    KAUST Repository

    Hussain, Syed Imtiaz

    2012-06-01

    Best relay selection is a bandwidth efficient technique for multiple relay environments without compromising the system performance. The problem of relay selection is more challenging in underlay cognitive networks due to strict interference constraints to the primary users. Generally, relay selection is done on the basis of maximum end-to-end signal to noise ratio (SNR). However, it requires large amounts of channel state information (CSI) at different network nodes. In this paper, we present and analyze a reactive relay selection scheme in underlay cognitive networks where the relays are operating with fixed gains near a primary user. The system model minimizes the amount of CSI required at different nodes and the destination selects the best relay on the basis of maximum relay to destination SNR. We derive close form expressions for the received SNR statistics, outage probability, bit error probability and average channel capacity of the system. Simulation results are also presented to confirm the validity of the derived expressions. © 2012 IEEE.

  9. Individual Channel Estimation in a Diamond Relay Network Using Relay-Assisted Training

    Directory of Open Access Journals (Sweden)

    Xianwen He

    2017-01-01

    Full Text Available We consider the training design and channel estimation in the amplify-and-forward (AF diamond relay network. Our strategy is to transmit the source training in time-multiplexing (TM mode while each relay node superimposes its own relay training over the amplified received data signal without bandwidth expansion. The principal challenge is to obtain accurate channel state information (CSI of second-hop link due to the multiaccess interference (MAI and cooperative data interference (CDI. To maintain the orthogonality between data and training, a modified relay-assisted training scheme is proposed to migrate the CDI, where some of the cooperative data at the relay are discarded to accommodate relay training. Meanwhile, a couple of optimal zero-correlation zone (ZCZ relay-assisted sequences are designed to avoid MAI. At the destination node, the received signals from the two relay nodes are combined to achieve spatial diversity and enhanced data reliability. The simulation results are presented to validate the performance of the proposed schemes.

  10. Iterative Relay Scheduling with Hybrid ARQ under Multiple User Equipment (Type II) Relay Environments

    KAUST Repository

    Nam, Sung Sik; Alouini, Mohamed-Slim; Choi, Seyeong

    2018-01-01

    -generation cellular systems (e.g., LTE-Advanced and beyond). The proposed IRS-HARQ aims to increase the achievable data rate by iteratively scheduling a relatively better UE relay closer to the end user in a probabilistic sense, provided that the relay-to-end user

  11. Capacity Bounds and Mapping Design for Binary Symmetric Relay Channels

    Directory of Open Access Journals (Sweden)

    Majid Nasiri Khormuji

    2012-12-01

    Full Text Available Capacity bounds for a three-node binary symmetric relay channel with orthogonal components at the destination are studied. The cut-set upper bound and the rates achievable using decode-and-forward (DF, partial DF and compress-and-forward (CF relaying are first evaluated. Then relaying strategies with finite memory-length are considered. An efficient algorithm for optimizing the relay functions is presented. The Boolean Fourier transform is then employed to unveil the structure of the optimized mappings. Interestingly, the optimized relay functions exhibit a simple structure. Numerical results illustrate that the rates achieved using the optimized low-dimensional functions are either comparable to those achieved by CF or superior to those achieved by DF relaying. In particular, the optimized low-dimensional relaying scheme can improve on DF relaying when the quality of the source-relay link is worse than or comparable to that of other links.

  12. Buffer-Aided Relaying with Adaptive Link Selection

    DEFF Research Database (Denmark)

    Zlatanov, Nikola; Schober, Robert; Popovski, Petar

    2013-01-01

    In this paper, we consider a simple network consisting of a source, a half-duplex decode-and-forward relay, and a destination. We propose a new relaying protocol employing adaptive link selection, i.e., in any given time slot, based on the channel state information of the source-relay and the relay......-destination link a decision is made whether the source or the relay transmits. In order to avoid data loss at the relay, adaptive link selection requires the relay to be equipped with a buffer such that data can be queued until the relay-destination link is selected for transmission. We study both delay......-constrained and delay-unconstrained transmission. For the delay-unconstrained case, we characterize the optimal link selection policy, derive the corresponding throughput, and develop an optimal power allocation scheme. For the delay-constrained case, we propose to starve the buffer of the relay by choosing...

  13. Coordinated Direct and Relay Transmission with Linear Non-Regenerative Relay Beamforming

    DEFF Research Database (Denmark)

    Sun, Fan; De Carvalho, Elisabeth; Popovski, Petar

    2012-01-01

    Joint processing of multiple communication flows in wireless systems has given rise to a number of novel transmission techniques, notably the two-way relaying, but also more general traffic scenarios, such as coordinated direct and relay (CDR) transmissions. In a CDR scheme the relay has a central...... role in managing the interference and boosting the overall system performance. In this letter we consider the case in which an amplify-and-forward relay has multiple antennas and can use beamforming to support the coordinated transmissions. We focus on one representative traffic type with one uplink...... user and one downlink user. Two different criteria for relay beamforming are analyzed: maximal weighted sum-rate and maximization of the worst-case weighted SNR. We propose iterative optimal solutions, as well as low-complexity near-optimal solutions....

  14. A genetic algorithm for multiple relay selection in two-way relaying cognitive radio networks

    KAUST Repository

    Alsharoa, Ahmad M.

    2013-09-01

    In this paper, we investigate a multiple relay selection scheme for two-way relaying cognitive radio networks where primary users and secondary users operate on the same frequency band. More specifically, cooperative relays using Amplifyand- Forward (AF) protocol are optimally selected to maximize the sum rate of the secondary users without degrading the Quality of Service (QoS) of the primary users by respecting a tolerated interference threshold. A strong optimization tool based on genetic algorithm is employed to solve our formulated optimization problem where discrete relay power levels are considered. Our simulation results show that the practical heuristic approach achieves almost the same performance of the optimal multiple relay selection scheme either with discrete or continuous power distributions. Copyright © 2013 by the Institute of Electrical and Electronic Engineers, Inc.

  15. Outage performance of opportunistic two-way amplify-and-forward relaying with outdated channel state information

    KAUST Repository

    Hwang, Kyusung

    2013-09-01

    In this paper, we study the outage performance of an amplify-and-forward (AF)-based two-way relaying (TWR) system with multiple relays where a single relay selection is performed based on outdated channel state information (CSI). Specifically, we propose a single relay selection scheme in AF-based TWR system under outdated CSI conditions. With this policy, we offer a statistical analysis of the signal-to-noise ratio per hop and analyze the outage probability with asymmetric outage thresholds based on CSI-assisted AF protocol. Additionally, we provide the exact and asymptotic expressions based on the provided statistical/joint statistical analyses of a dual-hop AF transmission. Finally, we verify our analytical results with some selected computer-based simulation results. © 1972-2012 IEEE.

  16. Discrete radioisotopic relays of a cyclic action

    International Nuclear Information System (INIS)

    Klempner, K.S.; Vasil'ev, A.G.

    1975-01-01

    A functional diagram of discrete radioisotopic relay equipment (RRP) with cyclic action was examined. An analysis of its rapid action and reliability under stationary conditions and transition regimes is presented. A structural diagram of radioisotopic relay equipment shows three radiation detectors, a pulse standardizer, an integrator and a power amplifier with a threshold cut-off device. It was established that the basic properties of the RRP - rapid action and reliability - are determined entirely by the counting rate of the average frequency of pulses from the radiation detector, n 0 and n 1 , in the 0 and 1 states (absence of current in the electromagnetic relay winding and activation of the winding of the output relay), capacities N 1 and N 2 of the dual counters, and the frequency of the transition threshold, f, of the generator. Formulas are presented which allow making engineering calculations for determining the optimum RRP parameters. High speed and reliability are shown, which are determined by the production purposes of the relay

  17. Cognitive Relay Networks: A Comprehensive Survey

    Directory of Open Access Journals (Sweden)

    Ayesha Naeem

    2015-07-01

    Full Text Available Cognitive radio is an emerging technology to deal with the scarcity and requirement of radio spectrum by dynamically assigning spectrum to unlicensed user . This revolutionary technology shifts the paradigm in the wireless system design by all owing unlicensed user the ability to sense, adapt and share the dynamic spectrum. Cognitive radio technology have been applied to different networks and applications ranging from wireless to public saf ety, smart grid, medical, rela y and cellular applications to increase the throughput and spectrum efficiency of the network. Among these applications, cognitive relay networks is one of the application where cognitive radio technology has been applied. Cognitiv e rela y network increases the network throughput by reducing the complete pa th loss and also by ensuring cooper ation among secondary users and cooperation among primary and secondary users. In this paper , our aim is to provide a survey on cognitive relay network. We also provide a detailed review on existing schemes in cognitive relay networks on the basis of relaying protocol, relay cooperation and channel model.

  18. Curcumin protects dopaminergic neurons against inflammation-mediated damage and improves motor dysfunction induced by single intranigral lipopolysaccharide injection.

    Science.gov (United States)

    Sharma, Neha; Sharma, Sheetal; Nehru, Bimla

    2017-06-01

    Various studies have indicated a lower incidence and prevalence of neurological conditions in people consuming curcumin. The ability of curcumin to target multiple cascades, simultaneously, could be held responsible for its neuroprotective effects. The present study was designed to investigate the potential of curcumin in minimizing microglia-mediated damage in lipopolysaccharide (LPS) induced model of PD. Altered microglial functions and increased inflammatory profile of the CNS have severe behavioral consequences. In the current investigation, a single injection of LPS (5 ug/5 µl PBS) was injected into the substantia nigra (SN) of rats, and curcumin [40 mg/kg b.wt (i.p.)] was administered daily for a period of 21 days. LPS triggered an inflammatory response characterized by glial activation [Iba-1 and glial fibrillary acidic protein (GFAP)] and pro-inflammatory cytokine production (TNF-α and IL-1β) leading to extensive dopaminergic loss and behavioral abnormality in rats. The behavioral observations, biochemical markers, quantification of dopamine and its metabolites (DOPAC and HVA) using HPLC followed by IHC of tyrosine hydroxylase (TH) were evaluated after 21 days of LPS injection. Curcumin supplementation prevented dopaminergic degeneration in LPS-treated animals by normalizing the altered levels of biomarkers. Also, a significant improvement in TH levels as well as behavioral parameters (actophotometer, rotarod, beam walking and grid walking tests) were seen in LPS injected rats. Curcumin shielded the dopaminergic neurons against LPS-induced inflammatory response, which was associated with suppression of glial activation (microglia and astrocytes) and transcription factor NF-κB as depicted from RT-PCR and EMSA assay. Curcumin also suppressed microglial NADPH oxidase activation as observed from NADPH oxidase activity. The results suggested that one of the important mechanisms by which curcumin mediates its protective effects in the LPS-induced PD

  19. Combined Rate and Power Allocation with Link Scheduling in Wireless Data Packet Relay Networks with Fading Channels

    OpenAIRE

    Subhrakanti Dey; Minyi Huang

    2007-01-01

    We consider a joint rate and power control problem in a wireless data traffic relay network with fading channels. The optimization problem is formulated in terms of power and rate selection, and link transmission scheduling. The objective is to seek high aggregate utility of the relay node when taking into account buffer load management and power constraints. The optimal solution for a single transmitting source is computed by a two-layer dynamic programming algorithm which leads to optimal ...

  20. An ancient neurotrophin receptor code; a single Runx/Cbfβ complex determines somatosensory neuron fate specification in zebrafish.

    Science.gov (United States)

    Gau, Philia; Curtright, Andrew; Condon, Logan; Raible, David W; Dhaka, Ajay

    2017-07-01

    In terrestrial vertebrates such as birds and mammals, neurotrophin receptor expression is considered fundamental for the specification of distinct somatosensory neuron types where TrkA, TrkB and TrkC specify nociceptors, mechanoceptors and proprioceptors/mechanoceptors, respectively. In turn, Runx transcription factors promote neuronal fate specification by regulating neurotrophin receptor and sensory receptor expression where Runx1 mediates TrkA+ nociceptor diversification while Runx3 promotes a TrkC+ proprioceptive/mechanoceptive fate. Here, we report in zebrafish larvae that orthologs of the neurotrophin receptors in contrast to terrestrial vertebrates mark overlapping and distinct subsets of nociceptors suggesting that TrkA, TrkB and TrkC do not intrinsically promote nociceptor, mechanoceptor and proprioceptor/mechanoceptor neuronal fates, respectively. While we find that zebrafish Runx3 regulates nociceptors in contrast to terrestrial vertebrates, it shares a conserved regulatory mechanism found in terrestrial vertebrate proprioceptors/mechanoceptors in which it promotes TrkC expression and suppresses TrkB expression. We find that Cbfβ, which enhances Runx protein stability and affinity for DNA, serves as an obligate cofactor for Runx in neuronal fate determination. High levels of Runx can compensate for the loss of Cbfβ, indicating that in this context Cbfβ serves solely as a signal amplifier of Runx activity. Our data suggests an alteration/expansion of the neurotrophin receptor code of sensory neurons between larval teleost fish and terrestrial vertebrates, while the essential roles of Runx/Cbfβ in sensory neuron cell fate determination while also expanded are conserved.

  1. Counterfactual quantum cryptography network with untrusted relay

    Science.gov (United States)

    Chen, Yuanyuan; Gu, Xuemei; Jiang, Dong; Xie, Ling; Chen, Lijun

    2015-07-01

    Counterfactual quantum cryptography allows two remote parties to share a secret key even though a physical particle is not in fact transmitted through the quantum channel. In order to extend the scope of counterfactual quantum cryptography, we use an untrusted relay to construct a multi-user network. The implementation issues are discussed to show that the scheme can be realized with current technologies. We also prove the practical security advantages of the scheme by eliminating the probability that an eavesdropper can directly access the signal or an untrusted relay can perform false operations.

  2. CERN Relay Race: information for drivers

    CERN Multimedia

    2012-01-01

    The CERN relay race will take place around the Meyrin site on Thursday, 24 May starting at 12.15. If possible, please avoid driving on the site during this 20-minute period. If you do meet runners while driving your car, please STOP until they have all passed. In addition, there will be a Nordic Walking event which will finish around 12.50. This should not block the roads, but please drive carefully during this time. Thank you for your cooperation. Details on how to register your team for the relay race can be found here.

  3. Deep space optical communication via relay satellite

    Science.gov (United States)

    Dolinar, S.; Vilnrotter, V.; Gagliardi, R.

    1981-01-01

    The application of optical communications for a deep space link via an earth-orbiting relay satellite is discussed. The system uses optical frequencies for the free-space channel and RF links for atmospheric transmission. The relay satellite is in geostationary orbit and contains the optics necessary for data processing and formatting. It returns the data to earth through the RF terrestrial link and also transmits an optical beacon to the satellite for spacecraft return pointing and for the alignment of the transmitting optics. Future work will turn to modulation and coding, pointing and tracking, and optical-RF interfacing.

  4. Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis.

    Science.gov (United States)

    Kielar, Catherine; Maddox, Lucy; Bible, Ellen; Pontikis, Charlie C; Macauley, Shannon L; Griffey, Megan A; Wong, Michael; Sands, Mark S; Cooper, Jonathan D

    2007-01-01

    Infantile neuronal ceroid lipofuscinosis (INCL) is caused by deficiency of the lysosomal enzyme, palmitoyl protein thioesterase 1 (PPT1). We have investigated the onset and progression of pathological changes in Ppt1 deficient mice (Ppt1-/-) and the development of their seizure phenotype. Surprisingly, cortical atrophy and neuron loss occurred only late in disease progression but were preceded by localized astrocytosis within individual thalamic nuclei and the progressive loss of thalamic neurons that relay different sensory modalities to the cortex. This thalamic neuron loss occurred first within the visual system and only subsequently in auditory and somatosensory relay nuclei or the inhibitory reticular thalamic nucleus. The loss of granule neurons and GABAergic interneurons followed in each corresponding cortical region, before the onset of seizure activity. These findings provide novel evidence for successive neuron loss within the thalamus and cortex in Ppt1-/- mice, revealing the thalamus as an important early focus of INCL pathogenesis.

  5. Switched diversity strategies for dual-hop amplify-and-forward relaying systems

    KAUST Repository

    Gaaloul, Fakhreddine

    2012-01-01

    This study investigates different receive single-branch switch-based diversity schemes for dual-hop amplify-and-forward relaying networks. Specifically, three receive processing algorithms are adopted, in which the receive branch is selected using the arbitrary selection algorithm, the switching algorithm, or the switching algorithm with post-examining best branch selection. The identification of the receive branch is carried out for two different system models. For the first model, a single-antenna relaying station is used in conjunction with a multiple-antenna transceiver, where the processing is performed independently of the first hop-fading conditions. The second model suggests the use of parallel deployment of single-antenna relays to transfer information from a multiple-antenna transmitter to a single-antenna receiver, where the active relaying station is determined based on the pre-combining end-to-end fading conditions. Performance comparisons for various transmission scenarios on the first hop are presented using new formulations for the statistics of the combined signal-to-noise ratio. Simulation results are also provided to validate the mathematical development and to verify the numerical computations. © 2012 The Institution of Engineering and Technology.

  6. Application of DIgSILENT POWERFACTORY software for modeling of industrial network relay protection system

    Directory of Open Access Journals (Sweden)

    Sučević Nikola

    2016-01-01

    Full Text Available This paper presents modeling of industrial network relay protection system using DIgSILENT PowerFactory software. The basis for the model of protection system is a model of a single substation in an industrial network. The paper presents the procedure for modeling of protective devices of 6 kV asynchronous motors, 6/0,4 kV/kV transformers as well as protection in the bus coupler and busbar protection. Protective relay system response for the simulated disturbances is shown in the paper.

  7. Application of DIgSILENT POWERFACTORY software for modeling of industrial network relay protection system

    OpenAIRE

    Sučević Nikola; Milošević Dejan

    2016-01-01

    This paper presents modeling of industrial network relay protection system using DIgSILENT PowerFactory software. The basis for the model of protection system is a model of a single substation in an industrial network. The paper presents the procedure for modeling of protective devices of 6 kV asynchronous motors, 6/0,4 kV/kV transformers as well as protection in the bus coupler and busbar protection. Protective relay system response for the simulated disturbances is shown in the paper.

  8. Outage performance of two-way DF relaying systems with a new relay selection metric

    KAUST Repository

    Hyadi, Amal

    2012-04-01

    This paper investigates a new constrained relay selection scheme for two-way relaying systems where two end terminals communicate simultaneously via a relay. The introduced technique is based on the maximization of the weighted sum rate of both users. To evaluate the performance of the proposed system, the outage probability is derived in a general case (where an arbitrary channel is considered), and then over independently but not necessarily identically distributed (i.n.i.d.) Rayleigh fading channels. The analytical results are verified through simulations. © 2012 IEEE.

  9. Advanced Strategic and Tactical Relay Request Management for the Mars Relay Operations Service

    Science.gov (United States)

    Allard, Daniel A.; Wallick, Michael N.; Gladden, Roy E.; Wang, Paul; Hy, Franklin H.

    2013-01-01

    This software provides a new set of capabilities for the Mars Relay Operations Service (MaROS) in support of Strategic and Tactical relay, including a highly interactive relay request Web user interface, mission control over relay planning time periods, and mission management of allowed strategic vs. tactical request parameters. Together, these new capabilities expand the scope of the system to include all elements critical for Tactical relay operations. Planning of replay activities spans a time period that is split into two distinct phases. The first phase is called Strategic, which begins at the time that relay opportunities are identified, and concludes at the point that the orbiter generates the flight sequences for on board execution. Any relay request changes from this point on are called Tactical. Tactical requests, otherwise called Orbit - er Relay State Changes (ORSC), are highly restricted in terms of what types of changes can be made, and the types of parameters that can be changed may differ from one orbiter to the next. For example, one orbiter may be able to delay the start of a relay request, while another may not. The legacy approach to ORSC management involves exchanges of e-mail with "requests for change" and "acknowledgement of approval," with no other tracking of changes outside of e-mail folders. MaROS Phases 1 and 2 provided the infrastructure for strategic relay for all supported missions. This new version, 3.0, introduces several capabilities that fully expand the scope of the system to include tactical relay. One new feature allows orbiter users to manage and "lock" Planning Periods, which allows the orbiter team to formalize the changeover from Strategic to Tactical operations. Another major feature allows users to interactively submit tactical request changes via a Web user interface. A third new feature allows orbiter missions to specify allowed tactical updates, which are automatically incorporated into the tactical change process

  10. Relay communications strategies for Mars exploration through 2020

    Science.gov (United States)

    Edwards, Charles D., Jr.; Arnold, B.; DePaula, R.; Kazz, G.; Lee, C.; Noreen, G.

    2005-01-01

    In this paper we will examine NASA's strategy for relay communications support of missions planned for this decade, and discuss options for longer-term relay network evolution in support of second-decade missions.

  11. Switched diversity strategies for dual-hop relaying systems

    KAUST Repository

    Gaaloul, Fakhreddine; Alouini, Mohamed-Slim; Radaydeh, Redha M.

    2011-01-01

    This paper investigates the effect of different switched diversity configurations on the implementation complexity and achieved performance of dual-hop amplify-and-forward (AF) relaying networks. A low-complexity model of the relay station

  12. protective relay studies for the nigerian national electric 330 kv

    African Journals Online (AJOL)

    user

    1985-09-01

    Sep 1, 1985 ... protective relay schemes of the National Electric Power Authority. Some of the basic ... Nigerian special system characteristics, schemes to correct existing protection inadequacies .... relays buried in the transformer. A reach of ...

  13. Dynamic Relaying in 3GPP LTE-Advanced Networks

    Directory of Open Access Journals (Sweden)

    Van Phan Vinh

    2009-01-01

    Full Text Available Relaying is one of the proposed technologies for LTE-Advanced networks. In order to enable a flexible and reliable relaying support, the currently adopted architectural structure of LTE networks has to be modified. In this paper, we extend the LTE architecture to enable dynamic relaying, while maintaining backward compatibility with LTE Release 8 user equipments, and without limiting the flexibility and reliability expected from relaying. With dynamic relaying, relays can be associated with base stations on a need basis rather than in a fixed manner which is based only on initial radio planning. Proposals are also given on how to further improve a relay enhanced LTE network by enabling multiple interfaces between the relay nodes and their controlling base stations, which can possibly be based on technologies different from LTE, so that load balancing can be realized. This load balancing can be either between different base stations or even between different networks.

  14. Capacity gains of buffer-aided moving relays

    KAUST Repository

    Zafar, Ammar

    2017-03-14

    This work investigates the gain due to reduction in path loss by deploying buffer-aided moving relaying. In particular, the increase in gain due to moving relays is studied for dual-hop broadcast channels and the bidirectional relay channel. It is shown that the exploited gains in these channels due to buffer-aided relaying can be enhanced by utilizing the fact that a moving relay can communicate with the terminal closest to it and store the data in the buffer and then forward the data to the intended destination when it comes in close proximity with the destination. Numerical results show that for both the considered channels the achievable rates are increased as compared to the case of stationary relays. Numerical results also show that more significant increase in performance is seen when the relay moves to-and-fro between the source and the relay.

  15. Dynamic Relaying in 3GPP LTE-Advanced Networks

    DEFF Research Database (Denmark)

    Teyeb, Oumer Mohammed; Van Phan, Vinh; Redana, Simone

    2009-01-01

    Relaying is one of the proposed technologies for LTE-Advanced networks. In order to enable a flexible and reliable relaying support, the currently adopted architectural structure of LTE networks has to be modified. In this paper, we extend the LTE architecture to enable dynamic relaying, while...... maintaining backward compatibility with LTE Release 8 user equipments, and without limiting the flexibility and reliability expected from relaying.With dynamic relaying, relays can be associated with base stations on a need basis rather than in a fixed manner which is based only on initial radio planning....... Proposals are also given on how to further improve a relay enhanced LTE network by enabling multiple interfaces between the relay nodes and their controlling base stations, which can possibly be based on technologies different from LTE, so that load balancing can be realized. This load balancing can...

  16. Improper Signaling for Virtual Full-Duplex Relay Systems

    KAUST Repository

    Gaafar, Mohamed

    2017-02-14

    Virtual full-duplex (VFD) is a powerful solution to compensate the rate loss of half-duplex relaying without the need to full-duplex capable nodes. Inter-relay interference (IRI) challenges the operation of VFD relaying systems. Recently, improper signaling is employed at both relays of the VFD to mitigate the IRI by imposing the same signal characteristics for both relays. To further boost the achievable rate performance, asymmetric time sharing VFD relaying system is adopted with different improper signals at the half-duplex relays. The joint tuning of the three design parameters improves the achievable rate performance at different ranges of IRI and different relays locations. Extensive simulation results are presented and analyzed to show the achievable rate gain of the proposed system and understand the system behavior.

  17. Improper Signaling for Virtual Full-Duplex Relay Systems

    KAUST Repository

    Gaafar, Mohamed; Amin, Osama; Schaefer, Rafael F.; Alouini, Mohamed-Slim

    2017-01-01

    Virtual full-duplex (VFD) is a powerful solution to compensate the rate loss of half-duplex relaying without the need to full-duplex capable nodes. Inter-relay interference (IRI) challenges the operation of VFD relaying systems. Recently, improper signaling is employed at both relays of the VFD to mitigate the IRI by imposing the same signal characteristics for both relays. To further boost the achievable rate performance, asymmetric time sharing VFD relaying system is adopted with different improper signals at the half-duplex relays. The joint tuning of the three design parameters improves the achievable rate performance at different ranges of IRI and different relays locations. Extensive simulation results are presented and analyzed to show the achievable rate gain of the proposed system and understand the system behavior.

  18. Capacity gains of buffer-aided moving relays

    KAUST Repository

    Zafar, Ammar; Shaqfeh, Mohammad; Alnuweiri, Hussein; Alouini, Mohamed-Slim

    2017-01-01

    This work investigates the gain due to reduction in path loss by deploying buffer-aided moving relaying. In particular, the increase in gain due to moving relays is studied for dual-hop broadcast channels and the bidirectional relay channel. It is shown that the exploited gains in these channels due to buffer-aided relaying can be enhanced by utilizing the fact that a moving relay can communicate with the terminal closest to it and store the data in the buffer and then forward the data to the intended destination when it comes in close proximity with the destination. Numerical results show that for both the considered channels the achievable rates are increased as compared to the case of stationary relays. Numerical results also show that more significant increase in performance is seen when the relay moves to-and-fro between the source and the relay.

  19. Full-diversity partial interference cancellation for multi-user wireless relaying networks

    KAUST Repository

    El Astal, M. T O

    2013-12-01

    We focus on the uplink channel of multi-user wireless relaying networks in a coverage extension scenario. The network consists of two users, a single half duplex (HD) relay and a destination, all equipped with multiple antennas. Perfect channel state information (CSI) is assumed to be available exclusively at the receiving nodes (i.e., the relay and the destination) while the users are assumed to be completely blind. The communication through the considered network takes place over two phases. During the first phase, both users send their information concurrently to the relay. The second phase consists of decoding the received data and forwarding it simultaneously to the destination. A transmission scheme that achieves full-diversity under partial interference cancellation (PIC) group decoding is proposed. Unlike many existing schemes, it allows the concurrent transmission in both phases while achieving the full-diversity gain of full time division multiple access (TDMA) transmission regardless of the number of antennas at each node. Numerical comparison with existing schemes in the literature is provided to corroborate our theoretical claims. It is found that our interference cancellation (IC) scheme clearly outperforms existing schemes at the expense of an affordable increase in decoding complexity at both of the relay and destination. © 2013 IEEE.

  20. A Quality-Aware Relay Node Placement Algorithm to Connect Disjoint WSN Segments with Topology Reorganized

    Directory of Open Access Journals (Sweden)

    Zheng Zimu

    2014-05-01

    Full Text Available Connecting numerous separate parts can be indispensable to simply WSNs that operate autonomously or partitions of a single segmented WSN. Linking them is subject to different intersegment quality of communication and service (QoC and QoS while relay nodes are deployed with their exact number and positions left to define, which is the problem that we focus on. Finding the optimal number and position of relays is NP-hard and therefore heuristics and approximation are pursued. This paper presents an effective approach to deploy appropriate relays to satisfy both the QoC and QoS requirements by introducing probabilistic topology control. The key idea is to regulate a new parallel rule and cost function for segments, which eventually maximizes the utilization of deployed node and avoids the deployment of additional relays as much as possible. The optimization problem is then mapped to finding the path that fulfills the both requirements together with least overheads. The experimental result is validated that although the number of relays is slightly increased to meet extra requirements, the network connectivity can be improved by up to 289.5 % with reorganized topology.

  1. Full-diversity partial interference cancellation for multi-user wireless relaying networks

    KAUST Repository

    El Astal, M. T O; Ismail, Amr; Alouini, Mohamed-Slim; Olivier, Jan Corné

    2013-01-01

    We focus on the uplink channel of multi-user wireless relaying networks in a coverage extension scenario. The network consists of two users, a single half duplex (HD) relay and a destination, all equipped with multiple antennas. Perfect channel state information (CSI) is assumed to be available exclusively at the receiving nodes (i.e., the relay and the destination) while the users are assumed to be completely blind. The communication through the considered network takes place over two phases. During the first phase, both users send their information concurrently to the relay. The second phase consists of decoding the received data and forwarding it simultaneously to the destination. A transmission scheme that achieves full-diversity under partial interference cancellation (PIC) group decoding is proposed. Unlike many existing schemes, it allows the concurrent transmission in both phases while achieving the full-diversity gain of full time division multiple access (TDMA) transmission regardless of the number of antennas at each node. Numerical comparison with existing schemes in the literature is provided to corroborate our theoretical claims. It is found that our interference cancellation (IC) scheme clearly outperforms existing schemes at the expense of an affordable increase in decoding complexity at both of the relay and destination. © 2013 IEEE.

  2. Joint Network Coding and Opportunistic Scheduling for the Bidirectional Relay Channel

    KAUST Repository

    Shaqfeh, Mohammad

    2013-05-27

    In this paper, we consider a two-way communication system in which two users communicate with each other through an intermediate relay over block-fading channels. We investigate the optimal opportunistic scheduling scheme in order to maximize the long-term average transmission rate in the system assuming symmetric information flow between the two users. Based on the channel state information, the scheduler decides that either one of the users transmits to the relay, or the relay transmits to a single user or broadcasts to both users a combined version of the two users’ transmitted information by using linear network coding. We obtain the optimal scheduling scheme by using the Lagrangian dual problem. Furthermore, in order to characterize the gains of network coding and opportunistic scheduling, we compare the achievable rate of the system versus suboptimal schemes in which the gains of network coding and opportunistic scheduling are partially exploited.

  3. Joint Network Coding and Opportunistic Scheduling for the Bidirectional Relay Channel

    KAUST Repository

    Shaqfeh, Mohammad; Alnuweiri, Hussein; Alouini, Mohamed-Slim; Zafar, Ammar

    2013-01-01

    In this paper, we consider a two-way communication system in which two users communicate with each other through an intermediate relay over block-fading channels. We investigate the optimal opportunistic scheduling scheme in order to maximize the long-term average transmission rate in the system assuming symmetric information flow between the two users. Based on the channel state information, the scheduler decides that either one of the users transmits to the relay, or the relay transmits to a single user or broadcasts to both users a combined version of the two users’ transmitted information by using linear network coding. We obtain the optimal scheduling scheme by using the Lagrangian dual problem. Furthermore, in order to characterize the gains of network coding and opportunistic scheduling, we compare the achievable rate of the system versus suboptimal schemes in which the gains of network coding and opportunistic scheduling are partially exploited.

  4. Relay protection features of frequency-adjustable electric drive

    Science.gov (United States)

    Kuprienko, V. V.

    2018-03-01

    The features of relay protection of high-voltage electric motors in composition of the frequency-adjustable electric drive are considered in the article. The influence of frequency converters on the stability of the operation of various types of relay protection used on electric motors is noted. Variants of circuits for connecting relay protection devices are suggested. The need to develop special relay protection devices for a frequency-adjustable electric drive is substantiated.

  5. Microprocessor protection relays: new prospects or new problems?

    OpenAIRE

    Gurevich, Vladimir

    2006-01-01

    The internal architecture and principles of operation of microprocessor-based devices including so-called "microprocessor protective relays" have little in common with devices called "electric relays". But microprocessor-based relay protection devices are gradually driving out the traditional electromechanical and even electronic relay protection of virtually from all fields of power and electrical engineering. Advantages of microprocessor-based protection means over traditional ones are far ...

  6. Challenging the neuronal MIBG uptake by pharmacological intervention: effect of a single dose of oral amitriptyline on regional cardiac MIBG uptake

    Energy Technology Data Exchange (ETDEWEB)

    Estorch, Montserrat; Carrio, Ignasi; Mena, Esther; Flotats, Albert; Camacho, Valle; Fuertes, Jordi [Autonomous University of Barcelona, Department of Nuclear Medicine, Hospital Sant Pau, Barcelona (Spain); Kulisewsky, Jaume [Autonomous University of Barcelona, Department of Neurology, Hospital Sant Pau, Barcelona (Spain); Narula, Jagat [Irvine College of Medicine, Division of Cardiology, University of California, Irvine, CA (United States)

    2004-12-01

    Imaging with metaiodobenzylguanidine (MIBG) is used for the assessment of neuronal dysfunction in various cardiovascular disorders. Although valuable information is obtained by resting MIBG imaging, it is conceivable that competitive interference with the re-uptake mechanism would exaggerate MIBG defects and might unmask subclinical neuronal dysfunction. Tricyclic antidepressants, such as amitriptyline, have been reported to significantly increase cardiac MIBG washout and inhibit uptake into presynaptic neurons. This study was undertaken to assess whether a single oral dose of amitriptyline could influence cardiac MIBG distribution. Six patients (aged 62-81 years; four males, two females) who had demonstrated a normal cardiac MIBG scan during work-up for movement disorders were studied. The patients underwent a second {sup 123}I-MIBG study after oral administration of 25 mg amitriptyline within 1 week. Single-photon emission computed tomography images were acquired at 4 h to assess the regional distribution of MIBG, after generation of polar maps and employing a 20-segment model. Mean percentage of peak activity was calculated for each segment at rest and after amitriptyline administration. After amitriptyline administration, there was a decrease in regional MIBG uptake in 10{+-}4 segments per patient [62/120 segments (52%): 37 segments with a 5-10% decrease, 25 segments with a >10% decrease]. This change was statistically significant in lateral (P=0.003), apical (P<0.0001) and inferior (P=0.03) regions. A single oral dose of amitriptyline can induce changes in the uptake and retention of cardiac MIBG, indicating the feasibility of use of pharmacological intervention in cardiac neurotransmission imaging. (orig.)

  7. 49 CFR 236.52 - Relayed cut-section.

    Science.gov (United States)

    2010-10-01

    ..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Rules and Instructions: All Systems Track Circuits § 236.52 Relayed cut-section. Where relayed cut-section is used in... 49 Transportation 4 2010-10-01 2010-10-01 false Relayed cut-section. 236.52 Section 236.52...

  8. 76 FR 72124 - Internet-Based Telecommunications Relay Service Numbering

    Science.gov (United States)

    2011-11-22

    ... Docket No. 10-191; FCC 11-123] Internet-Based Telecommunications Relay Service Numbering AGENCY: Federal..., the information collection associated with the Commission's Internet- Based Telecommunications Relay... Telecommunications Relay Service Numbering, CG Docket No. 03-123; WC Docket No. 05-196; WC Docket No. 10-191; FCC 11...

  9. 76 FR 65965 - Contributions to the Telecommunications Relay Services Fund

    Science.gov (United States)

    2011-10-25

    ...] Contributions to the Telecommunications Relay Services Fund AGENCY: Federal Communications Commission. ACTION... Telecommunications Relay Services (TRS) Fund in a manner prescribed by regulation that is consistent with and... . SUPPLEMENTARY INFORMATION: This is a summary of the Commission's Contributions to the Telecommunications Relay...

  10. Asymmetric Modulation Gains in Network Coded Relay Networks

    DEFF Research Database (Denmark)

    Roetter, Daniel Enrique Lucani; Fitzek, Frank

    2015-01-01

    Wireless relays have usually been considered in two ways. On the one hand, a physical layer approach focused on per-packet reliability and involving the relay on each packet transmission. On the other, recent approaches have relied on the judicious activation of the relay at the network level to ...

  11. A SDP based design of relay precoding for the power minimization of MIMO AF-relay networks

    KAUST Repository

    Rao, Anlei; Park, Kihong; Alouini, Mohamed-Slim

    2015-01-01

    Relay precoding for multiple-input and multiple-output (MIMO) relay networks has been approached by either optimizing the efficiency performance with given power consumption constraints or minimizing the power consumption with quality-of-service (Qo

  12. Two distinct populations of projection neurons in the rat lateral parafascicular thalamic nucleus and their cholinergic responsiveness.

    Science.gov (United States)

    Beatty, J A; Sylwestrak, E L; Cox, C L

    2009-08-04

    The lateral parafascicular nucleus (lPf) is a member of the intralaminar thalamic nuclei, a collection of nuclei that characteristically provides widespread projections to the neocortex and basal ganglia and is associated with arousal, sensory, and motor functions. Recently, lPf neurons have been shown to possess different characteristics than other cortical-projecting thalamic relay neurons. We performed whole cell recordings from lPf neurons using an in vitro rat slice preparation and found two distinct neuronal subtypes that were differentiated by distinct morphological and physiological characteristics: diffuse and bushy. Diffuse neurons, which had been previously described, were the predominant neuronal subtype (66%). These neurons had few, poorly-branching, extended dendrites, and rarely displayed burst-like action potential discharge, a ubiquitous feature of thalamocortical relay neurons. Interestingly, we discovered a smaller population of bushy neurons (34%) that shared similar morphological and physiological characteristics with thalamocortical relay neurons of primary sensory thalamic nuclei. In contrast to other thalamocortical relay neurons, activation of muscarinic cholinergic receptors produced a membrane hyperpolarization via activation of M(2) receptors in most lPf neurons (60%). In a minority of lPf neurons (33%), muscarinic agonists produced a membrane depolarization via activation of predominantly M(3) receptors. The muscarinic receptor-mediated actions were independent of lPf neuronal subtype (i.e. diffuse or bushy neurons); however the cholinergic actions were correlated with lPf neurons with different efferent targets. Retrogradely-labeled lPf neurons from frontal cortical fluorescent bead injections primarily consisted of bushy type lPf neurons (78%), but more importantly, all of these neurons were depolarized by muscarinic agonists. On the other hand, lPf neurons labeled by striatal injections were predominantly hyperpolarized by muscarinic

  13. Modelling and Verification of Relay Interlocking Systems

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth; Bliguet, Marie Le; Kjær, Andreas

    2010-01-01

    This paper describes how relay interlocking systems as used by the Danish railways can be formally modelled and verified. Such systems are documented by circuit diagrams describing their static layout. It is explained how to derive a state transition system model for the dynamic behaviour...

  14. Relay Feedback Analysis for Double Integral Plants

    Directory of Open Access Journals (Sweden)

    Zhen Ye

    2011-01-01

    Full Text Available Double integral plants under relay feedback are studied. Complete results on the uniqueness of solutions, existence, and stability of the limit cycles are established using the point transformation method. Analytical expressions are also given for determining the amplitude and period of a limit cycle from the plant parameters.

  15. First Things First: Internet Relay Chat Openings.

    Science.gov (United States)

    Rintel, E. Sean; Mulholland, Joan; Pittam, Jeffery

    2001-01-01

    Argues that Internet Relay Chat (IRC) research needs to systematically address links between interaction structures, technological mediation and the instantiation and development of interpersonal relationships. Finds that openings that occur directly following user's entries into public IRC channels are often ambiguous, can disrupt relationship…

  16. Iterative Relay Scheduling with Hybrid ARQ under Multiple User Equipment (Type II) Relay Environments

    KAUST Repository

    Nam, Sung Sik

    2018-01-09

    In this work, we propose an iterative relay scheduling with hybrid ARQ (IRS-HARQ) scheme which realizes fast jump-in/successive relaying and subframe-based decoding under the multiple user equipment (UE) relay environments applicable to the next-generation cellular systems (e.g., LTE-Advanced and beyond). The proposed IRS-HARQ aims to increase the achievable data rate by iteratively scheduling a relatively better UE relay closer to the end user in a probabilistic sense, provided that the relay-to-end user link should be operated in an open-loop and transparent mode. The latter is due to the fact that not only there are no dedicated control channels between the UE relay and the end user but also a new cell is not created. Under this open-loop and transparent mode, our proposed protocol is implemented by partially exploiting the channel state information based on the overhearing mechanism of ACK/NACK for HARQ. Further, the iterative scheduling enables UE-to-UE direct communication with proximity that offers spatial frequency reuse and energy saving.

  17. Relay Precoder Optimization in MIMO-Relay Networks With Imperfect CSI

    KAUST Repository

    Pandarakkottilil, Ubaidulla

    2011-11-01

    In this paper, we consider robust joint designs of relay precoder and destination receive filters in a nonregenerative multiple-input multiple-output (MIMO) relay network. The network consists of multiple source-destination node pairs assisted by a MIMO-relay node. The channel state information (CSI) available at the relay node is assumed to be imperfect. We consider robust designs for two models of CSI error. The first model is a stochastic error (SE) model, where the probability distribution of the CSI error is Gaussian. This model is applicable when the imperfect CSI is mainly due to errors in channel estimation. For this model, we propose robust minimum sum mean square error (SMSE), MSE-balancing, and relay transmit power minimizing precoder designs. The next model for the CSI error is a norm-bounded error (NBE) model, where the CSI error can be specified by an uncertainty set. This model is applicable when the CSI error is dominated by quantization errors. In this case, we adopt a worst-case design approach. For this model, we propose a robust precoder design that minimizes total relay transmit power under constraints on MSEs at the destination nodes. We show that the proposed robust design problems can be reformulated as convex optimization problems that can be solved efficiently using interior-point methods. We demonstrate the robust performance of the proposed design through simulations. © 2011 IEEE.

  18. Using a micromachined magnetostatic relay in commutating a DC motor

    Science.gov (United States)

    Tai, Yu-Chong (Inventor); Wright, John A. (Inventor); Lilienthal, Gerald (Inventor)

    2004-01-01

    A DC motor is commutated by rotating a magnetic rotor to induce a magnetic field in at least one magnetostatic relay in the motor. Each relay is activated in response to the magnetic field to deliver power to at least one corresponding winding connected to the relay. In some cases, each relay delivers power first through a corresponding primary winding and then through a corresponding secondary winding to a common node. Specific examples include a four-pole, three-phase motor in which each relay is activated four times during one rotation of the magnetic rotor.

  19. Opportunistic Fixed Gain Bidirectional Relaying with Outdated CSI

    KAUST Repository

    Khan, Fahd Ahmed; Tourki, Kamel; Alouini, Mohamed-Slim; Qaraqe, Khalid A.

    2015-01-01

    In a network with multiple relays, relay selection has been shown as an effective scheme to achieve diversity as well as to improve the overall throughput. This paper studies the impact of using outdated channel state information for relay selection on the performance of a network where two sources communicate with each other via fixed-gain amplify-and-forward relays. For a Rayleigh faded channel, closed-form expressions for the outage probability, moment generating function and symbol error rate are derived. Simulations results are also presented to corroborate the derived analytical results. It is shown that adding relays does not improve the performance if the channel is substantially outdated. Furthermore, relay location is also taken into consideration and it is shown that the performance can be improved by placing the relay closer to the source whose channel is more outdated. © 2015 IEEE.

  20. Opportunistic Fixed Gain Bidirectional Relaying with Outdated CSI

    KAUST Repository

    Khan, Fahd Ahmed

    2015-05-01

    In a network with multiple relays, relay selection has been shown as an effective scheme to achieve diversity as well as to improve the overall throughput. This paper studies the impact of using outdated channel state information for relay selection on the performance of a network where two sources communicate with each other via fixed-gain amplify-and-forward relays. For a Rayleigh faded channel, closed-form expressions for the outage probability, moment generating function and symbol error rate are derived. Simulations results are also presented to corroborate the derived analytical results. It is shown that adding relays does not improve the performance if the channel is substantially outdated. Furthermore, relay location is also taken into consideration and it is shown that the performance can be improved by placing the relay closer to the source whose channel is more outdated. © 2015 IEEE.

  1. Nogo-receptor 1 antagonization in combination with neurotrophin-4/5 is not superior to single factor treatment in promoting survival and morphological complexity of cultured dopaminergic neurons.

    Science.gov (United States)

    Seiler, Stefanie; Di Santo, Stefano; Sahli, Sebastian; Andereggen, Lukas; Widmer, Hans Rudolf

    2017-08-01

    Cell transplantation using ventral mesencephalic tissue is an experimental approach to treat Parkinson's disease. This approach is limited by poor survival of the transplants and the high number of dopaminergic neurons needed for grafting. Increasing the yield of dopaminergic neurons in donor tissue is of great importance. We have previously shown that antagonization of the Nogo-receptor 1 by NEP1-40 promoted survival of cultured dopaminergic neurons and exposure to neurotrophin-4/5 increased dopaminergic cell densities in organotypic midbrain cultures. We investigated whether a combination of both treatments offers a novel tool to further improve dopaminergic neuron survival. Rat embryonic ventral mesencephalic neurons grown as organotypic free-floating roller tube or primary dissociated cultures were exposed to neurotrophin-4/5 and NEP1-40. The combined and single factor treatment resulted in significantly higher numbers of tyrosine hydroxylase positive neurons compared to controls. Significantly stronger tyrosine hydroxylase signal intensity was detected by Western blotting in the combination-treated cultures compared to controls but not compared to single factor treatments. Neurotrophin-4/5 and the combined treatment showed significantly higher signals for the neuronal marker microtubule-associated protein 2 in Western blots compared to control while no effects were observed for the astroglial marker glial fibrillary acidic protein between groups, suggesting that neurotrophin-4/5 targets mainly neuronal cells. Finally, NEP1-40 and the combined treatment significantly augmented tyrosine hydroxylase positive neurite length. Summarizing, our findings substantiate that antagonization of the Nogo-receptor 1 promotes dopaminergic neurons but does not further increase the yield of dopaminergic neurons and their morphological complexity when combined with neurotrophin-4/5 hinting to the idea that these treatments might exert their effects by activating common

  2. End-to-end performance of cooperative relaying in spectrum-sharing systems with quality of service requirements

    KAUST Repository

    Asghari, Vahid Reza

    2011-07-01

    We propose adopting a cooperative relaying technique in spectrum-sharing cognitive radio (CR) systems to more effectively and efficiently utilize available transmission resources, such as power, rate, and bandwidth, while adhering to the quality of service (QoS) requirements of the licensed (primary) users of the shared spectrum band. In particular, we first consider that the cognitive (secondary) user\\'s communication is assisted by an intermediate relay that implements the decode-and-forward (DF) technique onto the secondary user\\'s relayed signal to help with communication between the corresponding source and the destination nodes. In this context, we obtain first-order statistics pertaining to the first- and second-hop transmission channels, and then, we investigate the end-to-end performance of the proposed spectrum-sharing cooperative relaying system under resource constraints defined to assure that the primary QoS is unaffected. Specifically, we investigate the overall average bit error rate (BER), ergodic capacity, and outage probability of the secondary\\'s communication subject to appropriate constraints on the interference power at the primary receivers. We then consider a general scenario where a cluster of relays is available between the secondary source and destination nodes. In this case, making use of the partial relay selection method, we generalize our results for the single-relay scheme and obtain the end-to-end performance of the cooperative spectrum-sharing system with a cluster of L available relays. Finally, we examine our theoretical results through simulations and comparisons, illustrating the overall performance of the proposed spectrum-sharing cooperative system and quantify its advantages for different operating scenarios and conditions. © 2011 IEEE.

  3. Relay entanglement and clusters of correlated spins

    Science.gov (United States)

    Doronin, S. I.; Zenchuk, A. I.

    2018-06-01

    Considering a spin-1/2 chain, we suppose that the entanglement passes from a given pair of particles to another one, thus establishing the relay transfer of entanglement along the chain. Therefore, we introduce the relay entanglement as a sum of all pairwise entanglements in a spin chain. For more detailed studying the effects of remote pairwise entanglements, we use the partial sums collecting entanglements between the spins separated by up to a certain number of nodes. The problem of entangled cluster formation is considered, and the geometric mean entanglement is introduced as a characteristic of quantum correlations in a cluster. Generally, the lifetime of a cluster decreases with an increase in its size.

  4. Excitable signal relay in Dictyostelium discoideum

    Science.gov (United States)

    Mestler, Troy; Schwab, David; Mehta, Pankaj; Gregor, Thomas

    2011-03-01

    The social amoeba D. discoideum transitions when starved from a collection of individual cells into a multicellular spore-complex. During this process, amoebae display several interesting phenomena including intercellular signaling, pattern formation, and cell differentiation. At the heart of these phenomena is the exchange of the signaling molecule cyclic-AMP, which has previously been extensively studied using a variety of indirect methods. Here we employ a sensor that uses a compound fluorescent protein whose emission spectrum changes in the presence of bound cyclic AMP to directly monitor, in real time and in vivo, intracellular cAMP concentrations. We use cells expressing this sensor in microchemostats to study intracellular cAMP concentrations at the single-cell level in response to precise, dynamically-controlled external cAMP stimulation. Specifically, we show that these cells display excitability much like that found in neurons and agree experimentally quite well with a modified FitzHugh-Nagumo dynamical systems model. This single-cell model sets groundwork for a comprehensive multicellular model that promises to explain emergent behavior in D. discoideum.

  5. Adjustable electronic load-alarm relay

    International Nuclear Information System (INIS)

    Mason, C.H.; Sitton, R.S.

    1976-01-01

    An improved electronic alarm relay for monitoring the current drawn by an ac motor or other electrical load is described. The circuit is designed to measure the load with high accuracy and to have excellent alarm repeatability. Chattering and arcing of the relay contacts are minimal. The operator can adjust the set point easily and can re-set both the high and the low alarm points by means of one simple adjustment. The relay includes means for generating a signal voltage proportional to the motor current. In a preferred form of the invention a first operational amplifier is provided to generate a first constant reference voltage which is higher than a preselected value of the signal voltage. A second operational amplifier is provided to generate a second constant reference voltage which is lower than the aforementioned preselected value of the signal voltage. A circuit comprising a first resistor serially connected to a second resistor is connected across the outputs of the first and second amplifiers, and the junction of the two resistors is connected to the inverting terminal of the second amplifier. Means are provided to compare the aforementioned signal voltage with both the first and second reference voltages and to actuate an alarm if the signal voltage is higher than the first reference voltage or lower than the second reference voltage

  6. A self-organizing state-space-model approach for parameter estimation in hodgkin-huxley-type models of single neurons.

    Directory of Open Access Journals (Sweden)

    Dimitrios V Vavoulis

    Full Text Available Traditional approaches to the problem of parameter estimation in biophysical models of neurons and neural networks usually adopt a global search algorithm (for example, an evolutionary algorithm, often in combination with a local search method (such as gradient descent in order to minimize the value of a cost function, which measures the discrepancy between various features of the available experimental data and model output. In this study, we approach the problem of parameter estimation in conductance-based models of single neurons from a different perspective. By adopting a hidden-dynamical-systems formalism, we expressed parameter estimation as an inference problem in these systems, which can then be tackled using a range of well-established statistical inference methods. The particular method we used was Kitagawa's self-organizing state-space model, which was applied on a number of Hodgkin-Huxley-type models using simulated or actual electrophysiological data. We showed that the algorithm can be used to estimate a large number of parameters, including maximal conductances, reversal potentials, kinetics of ionic currents, measurement and intrinsic noise, based on low-dimensional experimental data and sufficiently informative priors in the form of pre-defined constraints imposed on model parameters. The algorithm remained operational even when very noisy experimental data were used. Importantly, by combining the self-organizing state-space model with an adaptive sampling algorithm akin to the Covariance Matrix Adaptation Evolution Strategy, we achieved a significant reduction in the variance of parameter estimates. The algorithm did not require the explicit formulation of a cost function and it was straightforward to apply on compartmental models and multiple data sets. Overall, the proposed methodology is particularly suitable for resolving high-dimensional inference problems based on noisy electrophysiological data and, therefore, a

  7. An assessment of fire vulnerability for aged electrical relays

    International Nuclear Information System (INIS)

    Vigil, R.A.; Nowlen, S.P.

    1995-03-01

    There has been some concern that, as nuclear power plants age, protective measures taken to control and minimize the impact of fire may become ineffective, or significantly less effective, and hence result in an increased fire risk. One objective of the Fire Vulnerability of Aged Electrical Components Program is to assess the effects of aging and service wear on the fire vulnerability of electrical equipment. An increased fire vulnerability of components may lead to an overall increase in fire risk to the plant. Because of their widespread use in various electrical safety systems, electromechanical relays were chosen to be the initial components for evaluation. This test program assessed the impact of operational and thermal aging on the vulnerability of these relays to fire-induced damage. Only thermal effects of a fire were examined in this test program. The impact of smoke, corrosive materials, or fire suppression effects on relay performance were not addressed in this test program. The purpose of this test program was to assess whether the fire vulnerability of electrical relays increased with aging. The sequence followed for the test program was to: identify specific relay types, develop three fire scenarios, artificially age several relays, test the unaged and aged relays in the fire exposure scenarios, and compare the results. The relays tested were Agastat GPI, General Electric (GE) HMA, HGA, and HFA. At least two relays of each type were artificially aged and at least two relays of each type were new. Relays were operationally aged by cycling the relay under rated load for 2,000 operations. These relays were then thermally aged for 60 days with their coil energized

  8. GSFC network operations with Tracking and Data Relay Satellites

    Science.gov (United States)

    Spearing, R.; Perreten, D. E.

    The Tracking and Data Relay Satellite System (TDRSS) Network (TN) has been developed to provide services to all NASA User spacecraft in near-earth orbits. Three inter-relating entities will provide these services. The TN has been transformed from a network continuously changing to meet User specific requirements to a network which is flexible to meet future needs without significant changes in operational concepts. Attention is given to the evolution of the TN network, the TN capabilities-space segment, forward link services, tracking services, return link services, the three basic capabilities, single access services, multiple access services, simulation services, the White Sands Ground Terminal, the NASA communications network, and the network control center.

  9. Tracking and data relay satellite system (TDRSS) capabilities

    Science.gov (United States)

    Spearing, R. E.

    1985-10-01

    The Tracking and Data Relay Satellite System (TDRSS) is the latest implementation to tracking and data acquisition network for near-earth orbiting satellite support designed to meet the requirements of the current and projected (to the year 2000) satellite user community. The TDRSS consists of a space segment (SS) and a ground segment (GS) that fit within NASA's Space Network (SN) complex controlled at the Goddard Space Flight Center. The SS currently employs a single satellite, TDRS-1, with two additional satellites to be deployed in January 1986 and July 1986. The GS contains the communications and equipment required to manage the three TDR satellites and to transmit and receive information to and from TDRSS user satellites. Diagrams and tables illustrating the TDRSS signal characteristics, the situation of TDRSS within the SN, the SN operations and element interrelationships, as well as future plans for new missions are included.

  10. NeuronBank: a tool for cataloging neuronal circuitry

    Directory of Open Access Journals (Sweden)

    Paul S Katz

    2010-04-01

    Full Text Available The basic unit of any nervous system is the neuron. Therefore, understanding the operation of nervous systems ultimately requires an inventory of their constituent neurons and synaptic connectivity, which form neural circuits. The presence of uniquely identifiable neurons or classes of neurons in many invertebrates has facilitated the construction of cellular-level connectivity diagrams that can be generalized across individuals within a species. Homologous neurons can also be recognized across species. Here we describe NeuronBank.org, a web-based tool that we are developing for cataloging, searching, and analyzing neuronal circuitry within and across species. Information from a single species is represented in an individual branch of NeuronBank. Users can search within a branch or perform queries across branches to look for similarities in neuronal circuits across species. The branches allow for an extensible ontology so that additional characteristics can be added as knowledge grows. Each entry in NeuronBank generates a unique accession ID, allowing it to be easily cited. There is also an automatic link to a Wiki page allowing an encyclopedic explanation of the entry. All of the 44 previously published neurons plus one previously unpublished neuron from the mollusc, Tritonia diomedea, have been entered into a branch of NeuronBank as have 4 previously published neurons from the mollusc, Melibe leonina. The ability to organize information about neuronal circuits will make this information more accessible, ultimately aiding research on these important models.

  11. User Multiplexing in Relay Enhanced LTE-Advanced Networks

    DEFF Research Database (Denmark)

    Teyeb, Oumer Mohammed; Frederiksen, Frank; Redana, Simone

    2010-01-01

    is radio relaying. This uses relay nodes that act as surrogate base stations for mobile users whose radio links with the base stations are not experiencing good enough conditions. In the downlink, the data that is destined for the relayed users may first have to be multiplexed by the base station, sent...... over the wireless backhaul link towards the relay node, and de-multiplexed and forwarded to the individual users by the relay node. The reverse process also has to be undertaken in the uplink. In this paper, we present a novel multiplexing scheme which is able to adapt the addressing and bitmapping...... of user identification to the actual number of users being served by the relay nodes, and thus greatly reduce the multiplexing overhead....

  12. A performance analysis in AF full duplex relay selection network

    Science.gov (United States)

    Ngoc, Long Nguyen; Hong, Nhu Nguyen; Loan, Nguyen Thi Phuong; Kieu, Tam Nguyen; Voznak, Miroslav; Zdralek, Jaroslav

    2018-04-01

    This paper studies on the relaying selective matter in amplify-and-forward (AF) cooperation communication with full-duplex (FD) activity. Various relay choice models supposing the present of different instant information are investigated. We examine a maximal relaying choice that optimizes the instant FD channel capacity and asks for global channel state information (CSI) as well as partial CSI learning. To make comparison easy, accurate outage probability clauses and asymptote form of these strategies that give a diversity rank are extracted. From that, we can see clearly that the number of relays, noise factor, the transmittance coefficient as well as the information transfer power had impacted on their performance. Besides, the optimal relay selection (ORS) model can promote than that of the partial relay selection (PRS) model.

  13. Resource Allocation for the Multiband Relay Channel: A Building Block for Hybrid Wireless Networks

    Directory of Open Access Journals (Sweden)

    Kyounghwan Lee

    2010-01-01

    Full Text Available We investigate optimal resource allocation for the multiband relay channel. We find the optimal power and bandwidth allocation strategies that maximize the bounds on the capacity, by solving the corresponding max-min optimization problem. We provide sufficient conditions under which the associated max-min problem is equivalent to a supporting plane problem, which renders the solution for an arbitrary number of bands tractable. In addition, the sufficient conditions derived are general enough so that a class of utility functions can be accommodated with this formulation. As an example, we concentrate on the case where the source has two bands and the relay has a single band available and find the optimal resource allocation. We observe that joint power and bandwidth optimization always yields higher achievable rates than power optimization alone, establishing the merit of bandwidth sharing. Motivated by our analytical results, we examine a simple scenario where new channels become available for a transmitter to communicate; that is, new source to relay bands are added to a frequency division relay network. Given the channel conditions of the network, we establish the guidelines on how to allocate resources in order to achieve higher rates, depending on the relative quality of the available links.

  14. Full-Duplex Relay Selection in Cognitive Underlay Networks

    KAUST Repository

    Khafagy, Mohammad Galal

    2017-09-30

    In this work, we analyze the performance of full-duplex relay selection (FDRS) in spectrum-sharing networks. Contrary to half-duplex relaying, full-duplex relaying (FDR) enables simultaneous listening/forwarding at the secondary relay(s), thereby allowing for a higher spectral efficiency. However, since the source and relay simultaneously transmit in FDR, their superimposed signal at the primary receiver should now satisfy the existing interference constraint, which can considerably limit the secondary network throughput. In this regard, relay selection can offer an adequate solution to boost the secondary throughput while satisfying the imposed interference limit. We first analyze the performance of opportunistic FDRS with residual self-interference (RSI) by deriving the exact cumulative distribution function of its end-to-end signal-to-interference-plus-noise ratio under Nakagami-m fading. We also evaluate the offered diversity gain of relay selection for different full-duplex cooperation schemes in the presence/absence of a direct source-destination link. When the adopted RSI link gain model is sublinear in the relay power, which agrees with recent research findings, we show that remarkable diversity gain can be recovered even in the presence of an interfering direct link. Second, we evaluate the end-to-end performance of FDRS with interference constraints due to the presence of a primary receiver. Finally, the presented exact theoretical findings are verified by numerical simulations.

  15. Relay Telecommunications for the Coming Decade of Mars Exploration

    Science.gov (United States)

    Edwards, C.; DePaula, R.

    2010-01-01

    Over the past decade, an evolving network of relay-equipped orbiters has advanced our capabilities for Mars exploration. NASA's Mars Global Surveyor, 2001 Mars Odyssey, and Mars Reconnaissance Orbiter (MRO), as well as ESA's Mars Express Orbiter, have provided telecommunications relay services to the 2003 Mars Exploration Rovers, Spirit and Opportunity, and to the 2007 Phoenix Lander. Based on these successes, a roadmap for continued Mars relay services is in place for the coming decade. MRO and Odyssey will provide key relay support to the 2011 Mars Science Laboratory (MSL) mission, including capture of critical event telemetry during entry, descent, and landing, as well as support for command and telemetry during surface operations, utilizing new capabilities of the Electra relay payload on MRO and the Electra-Lite payload on MSL to allow significant increase in data return relative to earlier missions. Over the remainder of the decade a number of additional orbiter and lander missions are planned, representing new orbital relay service providers and new landed relay users. In this paper we will outline this Mars relay roadmap, quantifying relay performance over time, illustrating planned support scenarios, and identifying key challenges and technology infusion opportunities.

  16. Cooperative relay-based multicasting for energy and delay minimization

    KAUST Repository

    Atat, Rachad

    2012-08-01

    Relay-based multicasting for the purpose of cooperative content distribution is studied. Optimized relay selection is performed with the objective of minimizing the energy consumption or the content distribution delay within a cluster of cooperating mobiles. Two schemes are investigated. The first consists of the BS sending the data only to the relay, and the second scheme considers the scenario of threshold-based multicasting by the BS, where a relay is selected to transmit the data to the mobiles that were not able to receive the multicast data. Both schemes show significant superiority compared to the non-cooperative scenarios, in terms of energy consumption and delay reduction. © 2012 IEEE.

  17. Modified Dynamic Decode-and-Forward Relaying Protocol for Type II Relay in LTE-Advanced and Beyond.

    Science.gov (United States)

    Nam, Sung Sik; Alouini, Mohamed-Slim; Choi, Seyeong

    2016-01-01

    In this paper, we propose a modified dynamic decode-and-forward (MoDDF) relaying protocol to meet the critical requirements for user equipment (UE) relays in next-generation cellular systems (e.g., LTE-Advanced and beyond). The proposed MoDDF realizes the fast jump-in relaying and the sequential decoding with an application of random codeset to encoding and re-encoding process at the source and the multiple UE relays, respectively. A subframe-by-subframe decoding based on the accumulated (or buffered) messages is employed to achieve energy, information, or mixed combining. Finally, possible early termination of decoding at the end user can lead to the higher spectral efficiency and more energy saving by reducing the frequency of redundant subframe transmission and decoding. These attractive features eliminate the need of directly exchanging control messages between multiple UE relays and the end user, which is an important prerequisite for the practical UE relay deployment.

  18. Performance analysis of two-way amplify and forward relaying with adaptive modulation over multiple relay network

    KAUST Repository

    Hwang, Kyusung

    2011-02-01

    In this letter, we propose two-way amplify-and-forward relaying in conjunction with adaptive modulation in order to improve spectral efficiency of relayed communication systems while monitoring the required error performance. We also consider a multiple relay network where only the best relay node is utilized so that the diversity order increases while maintaining a low complexity of implementation as the number of relays increases. Based on the best relay selection criterion, we offer an upper bound on the signal-to-noise ratio to keep the performance analysis tractable. Our numerical examples show that the proposed system offers a considerable gain in spectral efficiency while satisfying the error rate requirements. © 2011 IEEE.

  19. Performance analysis of two-way amplify and forward relaying with adaptive modulation over multiple relay network

    KAUST Repository

    Hwang, Kyusung; Ko, Youngchai; Alouini, Mohamed-Slim

    2011-01-01

    In this letter, we propose two-way amplify-and-forward relaying in conjunction with adaptive modulation in order to improve spectral efficiency of relayed communication systems while monitoring the required error performance. We also consider a multiple relay network where only the best relay node is utilized so that the diversity order increases while maintaining a low complexity of implementation as the number of relays increases. Based on the best relay selection criterion, we offer an upper bound on the signal-to-noise ratio to keep the performance analysis tractable. Our numerical examples show that the proposed system offers a considerable gain in spectral efficiency while satisfying the error rate requirements. © 2011 IEEE.

  20. Uplink Capacity of 802.16j Mobile Multihop Relay Networks with Transparent Relays

    DEFF Research Database (Denmark)

    Wang, Hua; Andrews, Jeffrey G.; Iversen, Villy Bæk

    2009-01-01

    -to-end spectral efficiency. Furthermore, the position and the number of relay stations (RSs) have a great impact on the capacity gain. These results are further verified in the evaluation of the system Erlang capacity. The study demonstrates that with proper deployment of RSs and use of MIMO transmission...

  1. Diversity and wiring variability of visual local neurons in the Drosophila medulla M6 stratum.

    Science.gov (United States)

    Chin, An-Lun; Lin, Chih-Yung; Fu, Tsai-Feng; Dickson, Barry J; Chiang, Ann-Shyn

    2014-12-01

    Local neurons in the vertebrate retina are instrumental in transforming visual inputs to extract contrast, motion, and color information and in shaping bipolar-to-ganglion cell transmission to the brain. In Drosophila, UV vision is represented by R7 inner photoreceptor neurons that project to the medulla M6 stratum, with relatively little known of this downstream substrate. Here, using R7 terminals as references, we generated a 3D volume model of the M6 stratum, which revealed a retinotopic map for UV representations. Using this volume model as a common 3D framework, we compiled and analyzed the spatial distributions of more than 200 single M6-specific local neurons (M6-LNs). Based on the segregation of putative dendrites and axons, these local neurons were classified into two families, directional and nondirectional. Neurotransmitter immunostaining suggested a signal routing model in which some visual information is relayed by directional M6-LNs from the anterior to the posterior M6 and all visual information is inhibited by a diverse population of nondirectional M6-LNs covering the entire M6 stratum. Our findings suggest that the Drosophila medulla M6 stratum contains diverse LNs that form repeating functional modules similar to those found in the vertebrate inner plexiform layer. © 2014 Wiley Periodicals, Inc.

  2. Performance of hybrid-ARQ with incremental redundancy over relay channels

    KAUST Repository

    Chelli, Ali; Alouini, Mohamed-Slim

    2012-01-01

    In this paper, we consider a relay network consisting of a source, a relay, and a destination. The source transmits a message to the destination using hybrid automatic repeat request (HARQ) with incremental redundancy (IR). The relay overhears

  3. A study of optimization problem for amplify-and-forward relaying over weibull fading channels

    KAUST Repository

    Ikki, Salama Said; Aissa, Sonia

    2010-01-01

    This paper addresses the power allocation and relay positioning problems in amplify-and-forward cooperative networks operating in Weibull fading environments. We study adaptive power allocation (PA) with fixed relay location, optimal relay location

  4. Comparison of Low-Complexity Diversity Schemes for Dual-Hop AF Relaying Systems

    KAUST Repository

    Gaaloul, Fakhreddine

    2012-02-13

    This paper investigates the performance of two low-complexity combining schemes, which are based on one- or two-phase observation, to mitigate multipath fading in dual-hop amplify-and-forward relaying systems. For the one-phase-based combining, a single-antenna station is assumed to relay information from a multiple-antenna transmitter to a multiple-antenna receiver, and the activation of the receive antennas is adaptively performed based on the second-hop statistics, regardless of the first-hop conditions. On the other hand, the two-phase-based combining suggests using multiple single-antenna stations between the multiple-antenna transmitter and the single-antenna receiver, where the suitable set of active relays is identified according to the precombining end-to-end fading conditions. To facilitate comparisons between the two schemes, formulations for the statistics of the combined signal-to-noise ratio and some performance measures are presented. Numerical and simulation results are shown to clarify the tradeoff between the achieved diversity-array gain, the processing complexity, and the power consumption.

  5. Metabolic cytometry: capillary electrophoresis with two-color fluorescence detection for the simultaneous study of two glycosphingolipid metabolic pathways in single primary neurons.

    Science.gov (United States)

    Essaka, David C; Prendergast, Jillian; Keithley, Richard B; Palcic, Monica M; Hindsgaul, Ole; Schnaar, Ronald L; Dovichi, Norman J

    2012-03-20

    Metabolic cytometry is a form of chemical cytometry wherein metabolic cascades are monitored in single cells. We report the first example of metabolic cytometry where two different metabolic pathways are simultaneously monitored. Glycolipid catabolism in primary rat cerebella neurons was probed by incubation with tetramethylrhodamine-labeled GM1 (GM1-TMR). Simultaneously, both catabolism and anabolism were probed by coincubation with BODIPY-FL labeled LacCer (LacCer-BODIPY-FL). In a metabolic cytometry experiment, single cells were incubated with substrate, washed, aspirated into a capillary, and lysed. The components were separated by capillary electrophoresis equipped with a two-spectral channel laser-induced fluorescence detector. One channel monitored fluorescence generated by the metabolic products produced from GM1-TMR and the other monitored the metabolic products produced from LacCer-BODIPY-FL. The metabolic products were identified by comparison with the mobility of a set of standards. The detection system produced at least 6 orders of magnitude dynamic range in each spectral channel with negligible spectral crosstalk. Detection limits were 1 zmol for BODIPY-FL and 500 ymol for tetramethylrhodamine standard solutions.

  6. CERN Relay Race: sporty and colourful

    CERN Multimedia

    Andy Butterworth, CERN Running Club

    2013-01-01

    On Thursday 23 May, the 43rd CERN Relay Race took place, with 108 teams on the starting line, the largest participation ever!       The DG was present at the start and said a few words to encourage the runners. At 12:15, the Solar Club and handbike racers, led by Jean-Yves Le Meur, were the first to set off. And as last year, the relay runners were accompanied by an enthusiastic group of Nordic walkers. The first team across the finish line was "Velo City", in a very fast time of 10'31". New this year was a prize category for the best fancy dress, which was won by Les Schtroumpfs from the BE Department. The challenge for the best represented department was won for the third year in a row by FP, but second and third were HR and IT, up from 6th and 9th places last year. To see all the pictures of the event, click here.

  7. Satellite-Relayed Intercontinental Quantum Network

    Science.gov (United States)

    Liao, Sheng-Kai; Cai, Wen-Qi; Handsteiner, Johannes; Liu, Bo; Yin, Juan; Zhang, Liang; Rauch, Dominik; Fink, Matthias; Ren, Ji-Gang; Liu, Wei-Yue; Li, Yang; Shen, Qi; Cao, Yuan; Li, Feng-Zhi; Wang, Jian-Feng; Huang, Yong-Mei; Deng, Lei; Xi, Tao; Ma, Lu; Hu, Tai; Li, Li; Liu, Nai-Le; Koidl, Franz; Wang, Peiyuan; Chen, Yu-Ao; Wang, Xiang-Bin; Steindorfer, Michael; Kirchner, Georg; Lu, Chao-Yang; Shu, Rong; Ursin, Rupert; Scheidl, Thomas; Peng, Cheng-Zhi; Wang, Jian-Yu; Zeilinger, Anton; Pan, Jian-Wei

    2018-01-01

    We perform decoy-state quantum key distribution between a low-Earth-orbit satellite and multiple ground stations located in Xinglong, Nanshan, and Graz, which establish satellite-to-ground secure keys with ˜kHz rate per passage of the satellite Micius over a ground station. The satellite thus establishes a secure key between itself and, say, Xinglong, and another key between itself and, say, Graz. Then, upon request from the ground command, Micius acts as a trusted relay. It performs bitwise exclusive or operations between the two keys and relays the result to one of the ground stations. That way, a secret key is created between China and Europe at locations separated by 7600 km on Earth. These keys are then used for intercontinental quantum-secured communication. This was, on the one hand, the transmission of images in a one-time pad configuration from China to Austria as well as from Austria to China. Also, a video conference was performed between the Austrian Academy of Sciences and the Chinese Academy of Sciences, which also included a 280 km optical ground connection between Xinglong and Beijing. Our work clearly confirms the Micius satellite as a robust platform for quantum key distribution with different ground stations on Earth, and points towards an efficient solution for an ultralong-distance global quantum network.

  8. Satellite-Relayed Intercontinental Quantum Network.

    Science.gov (United States)

    Liao, Sheng-Kai; Cai, Wen-Qi; Handsteiner, Johannes; Liu, Bo; Yin, Juan; Zhang, Liang; Rauch, Dominik; Fink, Matthias; Ren, Ji-Gang; Liu, Wei-Yue; Li, Yang; Shen, Qi; Cao, Yuan; Li, Feng-Zhi; Wang, Jian-Feng; Huang, Yong-Mei; Deng, Lei; Xi, Tao; Ma, Lu; Hu, Tai; Li, Li; Liu, Nai-Le; Koidl, Franz; Wang, Peiyuan; Chen, Yu-Ao; Wang, Xiang-Bin; Steindorfer, Michael; Kirchner, Georg; Lu, Chao-Yang; Shu, Rong; Ursin, Rupert; Scheidl, Thomas; Peng, Cheng-Zhi; Wang, Jian-Yu; Zeilinger, Anton; Pan, Jian-Wei

    2018-01-19

    We perform decoy-state quantum key distribution between a low-Earth-orbit satellite and multiple ground stations located in Xinglong, Nanshan, and Graz, which establish satellite-to-ground secure keys with ∼kHz rate per passage of the satellite Micius over a ground station. The satellite thus establishes a secure key between itself and, say, Xinglong, and another key between itself and, say, Graz. Then, upon request from the ground command, Micius acts as a trusted relay. It performs bitwise exclusive or operations between the two keys and relays the result to one of the ground stations. That way, a secret key is created between China and Europe at locations separated by 7600 km on Earth. These keys are then used for intercontinental quantum-secured communication. This was, on the one hand, the transmission of images in a one-time pad configuration from China to Austria as well as from Austria to China. Also, a video conference was performed between the Austrian Academy of Sciences and the Chinese Academy of Sciences, which also included a 280 km optical ground connection between Xinglong and Beijing. Our work clearly confirms the Micius satellite as a robust platform for quantum key distribution with different ground stations on Earth, and points towards an efficient solution for an ultralong-distance global quantum network.

  9. The CERN Relay Race: A Runaway Success!

    CERN Multimedia

    Staff Association

    2018-01-01

    24th May saw the traditional Relay Race take place at CERN, organised jointly by the Running Club and the CERN Staff Association. In 2018, the Relay Race lived up to expectations with a record number of participants, with no fewer than 848 entries across different categories! In total 135 teams of 6 runners and 38 walkers completed the course on the Meyrin site in beautiful sunshine. Congratulations to all those who took part! Ghislain Roy, President of the Staff Association, fired the starting pistol for the first batch of runners, which included a team from the Directorate, with the Director General also taking part. Demonstrating interest in this event at the highest level of the Organization. Thank you for this much-appreciated commitment! Also a number of very high-level runners brought added excitement to the 2018 edition. The 1000-meter men’s race was won by Marcin Patecki from the CERN Running Club in 2’40, just in front of Baptiste Fieux from the Berthie Sport team who came in at...

  10. Record Participation in the Relay Race!

    CERN Multimedia

    2002-01-01

    CERN has a more sporting spirit than ever before. This is not the result of any survey, but the impression you got as soon as you saw the 62 teams of six runners each speeding around the laboratory in the 32nd annual relay race. This year 11 more teams competed than in 2001.   First changeover: Hervé Cornet takes over from Camille Ruiz Llamas for The Shabbys, and Sebastian Dorthe from Daniel Matteazzi for Charmilles Technologies. Jérôme Bendotti (EP/TA1) just holding off the team from the WHO at the finish. A total of 372 people ran together last Wednesday in this year's relay race, making for a record participation. It also seems that women are becoming more and more attracted by this competition, since this year there were eight ladies teams, also a new record. The first team were The Shabbys in a time of 10 minutes 45 seconds, finishing almost before the second team had started its last 300 metre leg. The 6 runners in each team cover distances of 1000, 800, 800,...

  11. Graduation Report : Directional relay coordination in ungrounded medium voltage networks using a real-time digital simulator

    NARCIS (Netherlands)

    Van der Meer, A.A.

    2009-01-01

    The thesis describes a comprehensive protection relay coordination study in ungrounded 10 kV distribution networks. Until now, single phase-toground faults (also: earth-faults) were never interrupted because resulting fault currents were relatively small. Since the earth-fault current amplitude is

  12. 76 FR 58424 - Transmission Relay Loadability Reliability Standard

    Science.gov (United States)

    2011-09-21

    ... distribution providers to set load-responsive phase protection relays according to specific criteria to ensure...-part R.1.10 allows transmission owners, generation owners and distribution providers to set transformer.... Thus, requiring that transformer fault protection relays are set to not expose the transformer to a...

  13. Improper signaling in two-path relay channels

    KAUST Repository

    Gaafar, Mohamed

    2017-07-03

    Inter-relay interference (IRI) challenges the operation of two-path relaying systems. Furthermore, the unavailability of the channel state information (CSI) at the source and the limited detection capabilities at the relays prevent neither eliminating the interference nor adopting joint detection at the relays nodes. Improper signaling is a powerful signaling scheme that has the capability to reduce the interference impact at the receiver side and improves the achievable rate performance. Therefore, improper signaling is adopted at both relays, which have access to the global CSI. Then, improper signal characteristics are designed to maximize the total end-to-end achievable rate at the relays. To this end, both the power and the circularity coefficient, a measure of the impropriety degree of the signal, are optimized at the relays. Although the optimization problem is not convex, optimal power allocation for both relays for a fixed circularity coefficient is obtained. Moreover, the circularity coefficient is tuned to maximize the rate for a given power allocation. Finally, a joint solution of the optimization problem is proposed using a coordinate descent method based on alternate optimization. The simulation results show that employing improper signaling improves the achievable rate at medium and high IRI.

  14. 77 FR 16435 - Transmission Relay Loadability Reliability Standard

    Science.gov (United States)

    2012-03-21

    ... conditions on all applicable transmission lines and transformers. I. Background A. Relay Protection Systems 2... and a power swing. If a power swing is detected, the protection system, ``blocks,'' or prevents the... to the reliability of the Bulk-Power System by requiring load-responsive phase protection relay...

  15. Protective relaying of power systems using mathematical morphology

    CERN Document Server

    Wu, QH; Ji, TY

    2009-01-01

    Discusses the development of novel protective relaying algorithms, using Mathematical Morphology (MM). This book introduces the fundamental principles of MM, and brings together the applications of MM to develop different protective relaying algorithms for the protection of a variety of power system components.

  16. Resource allocation for relay assisted cognitive radio networks

    KAUST Repository

    Zafar, Ammar; Alouini, Mohamed-Slim; Chen, Yunfei; Radaydeh, Redha M.

    2012-01-01

    transmission power and the relay transmission power. Numerical results show that the optimal sensing time is dependent on the primary user's signal-to-noise-ratio (SNR). They also show that SCR increases with increase in the number of relays. © 2012 IEEE.

  17. 47 CFR 11.20 - State Relay Network.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false State Relay Network. 11.20 Section 11.20... Network. This network is composed of State Relay (SR) sources, leased common carrier communications facilities or any other available communication facilities. The network distributes State EAS messages...

  18. MaROS Strategic Relay Planning and Coordination Interfaces

    Science.gov (United States)

    Allard, Daniel A.

    2010-01-01

    The Mars Relay Operations Service (MaROS) is designed to provide planning and analysis tools in support of ongoing Mars Network relay operations. Strategic relay planning requires coordination between lander and orbiter mission ground data system (GDS) teams to schedule and execute relay communications passes. MaROS centralizes this process, correlating all data relevant to relay coordination to provide a cohesive picture of the relay state. Service users interact with the system through thin-layer command line and web user interface client applications. Users provide and utilize data such as lander view periods of orbiters, Deep Space Network (DSN) antenna tracks, and reports of relay pass performance. Users upload and download relevant relay data via formally defined and documented file structures including some described in Extensible Markup Language (XML). Clients interface with the system via an http-based Representational State Transfer (ReST) pattern using Javascript Object Notation (JSON) formats. This paper will provide a general overview of the service architecture and detail the software interfaces and considerations for interface design.

  19. Effects of Unified Power Flow Controller (UPFC) on Distance Relay ...

    African Journals Online (AJOL)

    This paper investigates the effects of UPFC on Distance Relay tripping characteristics in Nigerian 330kV (North-Central) Network. Its operation is based on impedance measurement at the relaying point. However, the system performance is often impeded by certain operational or structural factors such as load angle, the ...

  20. Cognitive Spectrum Efficient Multiple Access Technique using Relay Systems

    DEFF Research Database (Denmark)

    Frederiksen, Flemming Bjerge; Prasad, Ramjee

    2007-01-01

    Methods to enhance the use of the frequency spectrum by automatical spectrum sensing plus spectrum sharing in a cognitive radio technology context will be presented and discussed in this paper. Ideas to increase the coverage of cellular systems by relay channels, relay stations and collaborate...

  1. Efficient Resource Scheduling by Exploiting Relay Cache for Cellular Networks

    Directory of Open Access Journals (Sweden)

    Chun He

    2015-01-01

    Full Text Available In relay-enhanced cellular systems, throughput of User Equipment (UE is constrained by the bottleneck of the two-hop link, backhaul link (or the first hop link, and access link (the second hop link. To maximize the throughput, resource allocation should be coordinated between these two hops. A common resource scheduling algorithm, Adaptive Distributed Proportional Fair, only ensures that the throughput of the first hop is greater than or equal to that of the second hop. But it cannot guarantee a good balance of the throughput and fairness between the two hops. In this paper, we propose a Two-Hop Balanced Distributed Scheduling (TBS algorithm by exploiting relay cache for non-real-time data traffic. The evolved Node Basestation (eNB adaptively adjusts the number of Resource Blocks (RBs allocated to the backhaul link and direct links based on the cache information of relays. Each relay allocates RBs for relay UEs based on the size of the relay UE’s Transport Block. We also design a relay UE’s ACK feedback mechanism to update the data at relay cache. Simulation results show that the proposed TBS can effectively improve resource utilization and achieve a good trade-off between system throughput and fairness by balancing the throughput of backhaul and access link.

  2. An automated thermoelectric power apparatus using electro-optic relays

    International Nuclear Information System (INIS)

    Chakravarti, A.; Ranganathan, R.

    1992-01-01

    We report the design and construction of a thermoelectric power apparatus using home-made electro-optic relays with Z-80A microprocessor for automatic data acquisition and control. The advantages of such relays made out of LED-LDR combinations for the measurement of ΔE and ΔT are discussed in details. (author). 7 refs., 5 figs

  3. Duplex Schemes in Multiple Antenna Two-Hop Relaying

    Directory of Open Access Journals (Sweden)

    Anja Klein

    2008-04-01

    Full Text Available A novel scheme for two-hop relaying defined as space division duplex (SDD relaying is proposed. In SDD relaying, multiple antenna beamforming techniques are applied at the intermediate relay station (RS in order to separate downlink and uplink signals of a bi-directional two-hop communication between two nodes, namely, S1 and S2. For conventional amplify-and-forward two-hop relaying, there appears a loss in spectral efficiency due to the fact that the RS cannot receive and transmit simultaneously on the same channel resource. In SDD relaying, this loss in spectral efficiency is circumvented by giving up the strict separation of downlink and uplink signals by either time division duplex or frequency division duplex. Two novel concepts for the derivation of the linear beamforming filters at the RS are proposed; they can be designed either by a three-step or a one-step concept. In SDD relaying, receive signals at S1 are interfered by transmit signals of S1, and receive signals at S2 are interfered by transmit signals of S2. An efficient method in order to combat this kind of interference is proposed in this paper. Furthermore, it is shown how the overall spectral efficiency of SDD relaying can be improved if the channels from S1 and S2 to the RS have different qualities.

  4. Implementation of a Relay Coordination System for the Mars Network

    Science.gov (United States)

    Allard, Daniel A.

    2010-01-01

    Mars network relay operations involve the coordination of lander and orbiter teams through long-term and short-term planning, tactical changes and post-pass analysis. Much of this coordination is managed through email traffic and point-to-point file data exchanges. It is often difficult to construct a complete and accurate picture of the relay situation at any given moment, as there is no centralized store of correlated relay data. The Mars Relay Operations Service (MaROS) is being implemented to address the problem of relay coordination for current and next-generation relay missions. The service is provided for the purpose of coordinating communications sessions between landed spacecraft assets and orbiting spacecraft assets at Mars. The service centralizes a set of functions previously distributed across multiple spacecraft operations teams, and as such greatly improves visibility into the end-to-end strategic coordination process. Most of the process revolves around the scheduling of communications sessions between the spacecraft during periods of time when a landed asset on Mars is geometrically visible by an orbiting spacecraft. These "relay" sessions are used to transfer data both to and from the landed asset via the orbiting asset on behalf of Earth-based spacecraft operators. This paper will discuss the relay coordination problem space, overview the architecture and design selected to meet system requirements, and describe the first phase of system implementation

  5. 77 FR 1039 - Internet-Based Telecommunications Relay Service Numbering

    Science.gov (United States)

    2012-01-09

    ... FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 64 [WC Docket No. 10-191; Report No. 2939] Internet... toll-free numbers by users of Internet- based Telecommunications Relay Services (iTRS). DATES... any rules of particular applicability. Subject: Internet-Based Telecommunications Relay Service...

  6. Using the 5 P Relay in Task Groups

    Science.gov (United States)

    Stanley, Paula Helen

    2006-01-01

    This article describes the 5 P Relay, a group exercise that can increase the effectiveness of task groups. The 5 P Relay is based on the principles and concepts of the Invitational Model, which emphasizes the importance of assessing the effectiveness or health of five aspects of an organization's environment: people, places, programs, processes,…

  7. Analysis of Relay Selection Game in a Cooperative Communication Scenario

    DEFF Research Database (Denmark)

    Craciunescu, Razvan; Mihovska, Albena; Halunga, Simona

    This paper analysis the performances of a proposed set of functions that model the relay selection process in a cooperative communication scenario. The behavior and influence proposed functions create a mechanism for selecting the best relays to be used to send certain types of data. The mechanism...... of comparison between the bit error rate of the proposed mechanism and the direct communication....

  8. Improper signaling in two-path relay channels

    KAUST Repository

    Gaafar, Mohamed; Amin, Osama; Schaefer, Rafael F.; Alouini, Mohamed-Slim

    2017-01-01

    Inter-relay interference (IRI) challenges the operation of two-path relaying systems. Furthermore, the unavailability of the channel state information (CSI) at the source and the limited detection capabilities at the relays prevent neither eliminating the interference nor adopting joint detection at the relays nodes. Improper signaling is a powerful signaling scheme that has the capability to reduce the interference impact at the receiver side and improves the achievable rate performance. Therefore, improper signaling is adopted at both relays, which have access to the global CSI. Then, improper signal characteristics are designed to maximize the total end-to-end achievable rate at the relays. To this end, both the power and the circularity coefficient, a measure of the impropriety degree of the signal, are optimized at the relays. Although the optimization problem is not convex, optimal power allocation for both relays for a fixed circularity coefficient is obtained. Moreover, the circularity coefficient is tuned to maximize the rate for a given power allocation. Finally, a joint solution of the optimization problem is proposed using a coordinate descent method based on alternate optimization. The simulation results show that employing improper signaling improves the achievable rate at medium and high IRI.

  9. Protective Relay Studies for the Nigerian National Electric 330 KV ...

    African Journals Online (AJOL)

    The fundamental reasons for requiring these specific protective relaying features are also reviewed. Other protective relaying schemes that can accomplish the same basic protection objectives are presented. Based on the Nigerian special system characteristics, schemes to correct existing protection inadequacies are ...

  10. Relay Coordination in the Protection of Radially-Connected Power ...

    African Journals Online (AJOL)

    Protective relays detect intolerable or unwanted conditions within an assigned area, and then trip or open one or more circuit breakers to isolate the problem area before it can damage or otherwise interfere with the eective operation of the rest of the power system. It often happens that a substation feeder relay and ...

  11. Quasi-period oscillations of relay feedback systems

    International Nuclear Information System (INIS)

    Wen Guilin; Wang Qingguo; Lee, T.H.

    2007-01-01

    This paper presents an analytical method for investigation of the existence and stability of quasi-period oscillations (torus solutions) for a class of relay feedback systems. The idea is to analyze Poincare map from one switching surface to the next based on the Hopf bifurcation theory of maps. It is shown that there exist quasi-period oscillations in certain relay feedback systems

  12. Cooperative relay-based multicasting for energy and delay minimization

    KAUST Repository

    Atat, Rachad; Yaacoub, Elias E.; Alouini, Mohamed-Slim; Abu-Dayya, Adnan A.

    2012-01-01

    mobiles. Two schemes are investigated. The first consists of the BS sending the data only to the relay, and the second scheme considers the scenario of threshold-based multicasting by the BS, where a relay is selected to transmit the data to the mobiles

  13. A novel framework on exact average symbol error probabilities of multihop transmission over amplify-and-forward relay fading channels

    KAUST Repository

    Yilmaz, Ferkan

    2010-09-01

    In this paper, we propose an analytical framework on the exact computation of the average symbol error probabilities (ASEP) of multihop transmission over generalized fading channels when an arbitrary number of amplify-and-forward relays is used. Our approach relies on moment generating function (MGF) framework to obtain exact single integral expressions which can be easily computed by Gauss-Chebyshev Quadrature (GCQ) rule. As such, the derived results are a convenient tool to analyze the ASEP performance of multihop transmission over amplify-and-forward relay fading channels. Numerical and simulation results, performed to verify the correctness of the proposed formulation, are in perfect agreement. © 2010 IEEE.

  14. A novel framework on exact average symbol error probabilities of multihop transmission over amplify-and-forward relay fading channels

    KAUST Repository

    Yilmaz, Ferkan; Kucur, Oǧuz; Alouini, Mohamed-Slim

    2010-01-01

    In this paper, we propose an analytical framework on the exact computation of the average symbol error probabilities (ASEP) of multihop transmission over generalized fading channels when an arbitrary number of amplify-and-forward relays is used. Our approach relies on moment generating function (MGF) framework to obtain exact single integral expressions which can be easily computed by Gauss-Chebyshev Quadrature (GCQ) rule. As such, the derived results are a convenient tool to analyze the ASEP performance of multihop transmission over amplify-and-forward relay fading channels. Numerical and simulation results, performed to verify the correctness of the proposed formulation, are in perfect agreement. © 2010 IEEE.

  15. Kappe neurons, a novel population of olfactory sensory neurons.

    Science.gov (United States)

    Ahuja, Gaurav; Bozorg Nia, Shahrzad; Zapilko, Veronika; Shiriagin, Vladimir; Kowatschew, Daniel; Oka, Yuichiro; Korsching, Sigrun I

    2014-02-10

    Perception of olfactory stimuli is mediated by distinct populations of olfactory sensory neurons, each with a characteristic set of morphological as well as functional parameters. Beyond two large populations of ciliated and microvillous neurons, a third population, crypt neurons, has been identified in teleost and cartilaginous fishes. We report here a novel, fourth olfactory sensory neuron population in zebrafish, which we named kappe neurons for their characteristic shape. Kappe neurons are identified by their Go-like immunoreactivity, and show a distinct spatial distribution within the olfactory epithelium, similar to, but significantly different from that of crypt neurons. Furthermore, kappe neurons project to a single identified target glomerulus within the olfactory bulb, mdg5 of the mediodorsal cluster, whereas crypt neurons are known to project exclusively to the mdg2 glomerulus. Kappe neurons are negative for established markers of ciliated, microvillous and crypt neurons, but appear to have microvilli. Kappe neurons constitute the fourth type of olfactory sensory neurons reported in teleost fishes and their existence suggests that encoding of olfactory stimuli may require a higher complexity than hitherto assumed already in the peripheral olfactory system.

  16. Security-Reliability Trade-Off Analysis for Multiuser SIMO Mixed RF/FSO Relay Networks With Opportunistic User Scheduling

    KAUST Repository

    El-Malek, Ahmed H. Abd

    2016-05-24

    In this paper, we study the performance of multiuser single-input multiple-output mixed radio frequency (RF)/free space optical (FSO) relay network with opportunistic user scheduling. The considered system includes multiple users, one amplify-and-forward relay, one destination, and a multiple-antenna eavesdropper. The users are connected with the relay node through RF links and the relay is connected with the destination through an FSO link. Both maximum ratio combining and selection combining schemes are used at the multiple-antenna relay to combine the signal received from the best user on different antennas. The RF/FSO channels models are assumed to follow Nakagami-m/gamma-gamma fading models with pointing errors. Closed-form expressions are derived for the outage probability, average symbol error probability, and ergodic channel capacity. Then, the power of the selected best user is determined to minimize the system asymptotic outage probability under the dominant RF or FSO link. Then, the considered system secrecy performance is investigated, where the closed-form expressions for the intercept probability are derived. Finally, we propose a new cooperative jamming model in which the worst user is selected by the authorized system to jam the existing eavesdropper. Monte-Carlo simulations are provided to validate the achieved exact and asymptotic results.

  17. Enhancing Physical Layer Security of Multiuser SIMO Mixed RF/FSO Relay Networks with Multi-Eavesdroppers

    KAUST Repository

    El-Malek, Ahmed H. Abd

    2017-02-09

    In this paper, we investigate the secrecy performance of multiuser (MU) single-input multiple-output (SIMO) mixed radio frequency (RF)/free space optical (FSO) relay network with opportunistic user scheduling and multiple eavesdropping attacks. The considered system includes multiple users, one amplify-and-froward (AF) relay, one destination and multiple eavesdroppers. The users are connected with a multi-antenna relay through RF links and the relay is connected with the destination through an FSO link. Maximal ratio combining (MRC) scheme is used at the relay node to combine the received signals at its different antennas. The RF/FSO channels are assumed to follow Nakagami-m/Gamma-Gamma fading models with considering the effect of pointing errors. In particular, we derive closed- form expressions for the exact and asymptotic outage probabilities. The asymptotic outage results are then used to obtain the optimal RF transmission power based on the dominant link between the RF and FSO links. Then, the considered system secrecy performance is investigated in the presence of multi- eavesdroppers where exact closed-form expression for the intercept probability is derived. Finally, a cooperative jamming model is proposed along with power allocation to enhance the system secrecy performance. Monte-Carlo simulations are provided to validate the achieved exact and asymptotic results.

  18. Multiple relay selection for delay-limited applications

    KAUST Repository

    Alsharoa, Ahmad M.

    2013-12-01

    A multiple relay selection system model that implements the decode-and-forward mode is investigated. All communication nodes are assumed to be equipped by multiple antennas. Furthermore, lattices space-time coded multiple-input multiple-output half duplex channel is applied. The main goal is to increase the throughput of the system by selecting multiple number of relays. The selection criteria depends on the maximum decoding delay at relays where the system implements a decoding time-out algorithm at each relay. This leads to a significant saving in the overall system power consumptions and attempts to solve the relays synchronization problem. All results are presented using numerical simulations. © 2012 IEEE.

  19. Sum-Rate Maximization of Coordinated Direct and Relay Systems

    DEFF Research Database (Denmark)

    Sun, Fan; Popovski, Petar; Thai, Chan

    2012-01-01

    Joint processing of multiple communication flows in wireless systems has given rise to a number of novel transmission techniques, notably the two-way relaying based on wireless network coding. Recently, a related set of techniques has emerged, termed coordinated direct and relay (CDR) transmissions......, where the constellation of traffic flows is more general than the two-way. Regardless of the actual traffic flows, in a CDR scheme the relay has a central role in managing the interference and boosting the overall system performance. In this paper we investigate the novel transmission modes, based...... on amplify-and-forward, that arise when the relay is equipped with multiple antennas and can use beamforming. We focus on one representative traffic type, with one uplink and one downlink users and consider the achievable sum-rate maximization relay beamforming. The beamforming criterion leads to a non...

  20. Beamforming Design for Coordinated Direct and Relay Systems

    DEFF Research Database (Denmark)

    Sun, Fan; De Carvalho, Elisabeth; Thai, Chan

    2012-01-01

    Joint processing of multiple communication flows in wireless systems has given rise to a number of novel transmission techniques, notably the two-way relaying based on wireless network coding. Recently, a related set of techniques has emerged, termed coordinated direct and relay (CDR) transmissions......, where the constellation of traffic flows is more general than the two-way. Regardless of the actual traffic flows, in a CDR scheme the relay has a central role in managing the interference. In this paper we investigate the novel transmission modes, based on amplify-and-forward, that arise when the relay...... an iterative solution, as well as derive an upper performance bound. The numerical results demonstrate a clear benefit from usage of multiple antennas at the relay node....

  1. Effects of relay chatter in seismic probabilistic safety analysis

    International Nuclear Information System (INIS)

    Reed, J.W.; Shiu, K.K.

    1985-01-01

    In the Zion and Indian Point Probabilistic Safety Studies, relay chatter was dismissed as a credible event and hence was not formally included in the analyses. Although little discussion is given in the Zion and Indian Point PSA documentation concerning the basis for this decision, it has been expressed informally that it was assumed that the operators will be able to reset all relays in a timely manner. Currently, it is the opinion of many professionals that this may be an oversimplification. The three basic areas which must be considered in addressing relay chatter include the fragility of the relays per se, the reliability of the operators to reset the relays and finally the systems response aspects. Each of these areas is reviewed and the implications for seismic PSA are discussed. Finally, recommendations for future research are given

  2. An RSS based location estimation technique for cognitive relay networks

    KAUST Repository

    Qaraqe, Khalid A.

    2010-11-01

    In this paper, a received signal strength (RSS) based location estimation method is proposed for a cooperative wireless relay network where the relay is a cognitive radio. We propose a method for the considered cognitive relay network to determine the location of the source using the direct and the relayed signal at the destination. We derive the Cramer-Rao lower bound (CRLB) expressions separately for x and y coordinates of the location estimate. We analyze the effects of cognitive behaviour of the relay on the performance of the proposed method. We also discuss and quantify the reliability of the location estimate using the proposed technique if the source is not stationary. The overall performance of the proposed method is presented through simulations. ©2010 IEEE.

  3. Relay exchanges in elite short track speed skating.

    Science.gov (United States)

    Hext, Andrew; Heller, Ben; Kelley, John; Goodwill, Simon

    2017-06-01

    In short track speed skating, the relay exchange provides an additional strategic component to races by allowing a team to change the skater involved in the pack race. Typically executed every 1½ laps, it is the belief of skaters and coaches that during this period of the race, time can be gained or lost due to the execution of the relay exchange. As such, the aim of this study was to examine the influence of the relay exchange on a team's progression through a 5000 m relay race. Using data collected from three World Cup relay events during the 2012-2013 season, the time taken to complete the straight for the scenarios with and without the relay exchange were compared at different skating speeds for the corner exit prior to the straight. Overall, the influence of the relay exchange was found to be dependent on this corner exit speed. At slower corner exit speeds (12.01-13.5 m/s), relay exchange straight times were significantly faster than the free skating scenario (P < 0.01). While at faster corner exit speeds (14.01-15 m/s), straight times were significantly slower (P < 0.001). The findings of this study suggest that the current norm of executing relay exchanges every 1½ laps may not be optimal. Instead, varying the frequency of relay exchange execution throughout the race could allow: (1) time to be gained relative to other teams; and (2) facilitate other race strategies by providing an improved opportunity to overtake.

  4. Relay protection coordination with generator capability curve, excitation system limiters and power system relay protections settings

    Directory of Open Access Journals (Sweden)

    Buha Danilo

    2016-01-01

    Full Text Available The relay protection settings performed in the largest thermal powerplant (TE "Nikola Tesla B" are reffered and explained in this paper. The first calculation step is related to the coordination of the maximum stator current limiter settings, the overcurrent protection with inverse characteristics settings and the permitted overload of the generator stator B1. In the second calculation step the settings of impedance generator protection are determined, and the methods and criteria according to which the calculations are done are described. Criteria used to provide the protection to fulfill the backup protection role in the event of malfunction of the main protection of the transmission system. are clarified. The calculation of all protection functions (32 functions of generator B1 were performed in the project "Coordination of relay protection blocks B1 and B2 with the system of excitation and power system protections -TENT B".

  5. Semiconductor relay and its manufacture method. Handotai relay oyobi sono seizo hoho

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, M

    1993-06-01

    The invention relates to a semiconductor relay in which a light emitting diode and a photovoltaic element are arranged in the opposite positions and connected with a light connection and aims to present a light transmission path to transmit input signals to the light emitting diode to the side of the photovoltaic element with a negligible light loss effectively. The invention presents a semiconductor relay, in which a light emitting diode loaded on the first lead frame and the light receiving part of the photovoltaic element to drive a MOSFET element loaded on the second lead frame and acting as a switch element are connected through an insulator tube with an opaque outer wall, and the interior of the insulator tube is filled with a transparent insulating filler, so that the invention affords a light transmission path without light leakage from the interior of the opaque insulator tube and with the stability in the form and no light loss. 3 figs.

  6. Exact capacity analysis of multihop transmission over amplify-and-forward relay fading channels

    KAUST Repository

    Yilmaz, Ferkan; Kucur, Oǧuz; Alouini, Mohamed-Slim

    2010-01-01

    In this paper, we propose an analytical framework on the exact computation of the average capacity of multihop transmission over amplify-and-forward relay fading channels. Our approach relies on the algebraic combination of Mellin and Laplace transforms to obtain exact single integral expressions which can be easily computed by Gauss-Chebyshev Quadrature (GCQ) rule. As such, the derived results are a convenient tool to analyze the average capacity of multihop transmission over amplify-and-forward relay fading channels. As an application of the analytical framework on the exact computation of the average capacity of multihop transmission, some examples are accentuated for generalized Nakagami-m fading channels. Numerical and simulation results, performed to verify the correctness of the proposed formulation, are in perfect agreement. ©2010 IEEE.

  7. Outage probability of dual-hop FSO fixed gain relay transmission systems

    KAUST Repository

    Zedini, Emna

    2016-12-24

    In this paper, we analyze the end-to-end performance of dual-hop free-space optical (FSO) fixed gain relaying systems in the presence of atmospheric turbulence as well as pointing errors. More specifically, an exact closed-form expression for the outage probability is presented in terms of the bivariate Fox\\'s H function that accounts for both heterodyne detection as well as intensity modulation with direct detection. At high signal-to-noise ratio (SNR) regime, we provide very tight asymptotic result for this performance metric in terms of simple elementary functions. By using dual-hop FSO relaying, we demonstrate a better system performance as compared to the single FSO link. Numerical and Monte-Carlo simulation results are provided to verify the accuracy of the newly proposed results, and a perfect agreement is observed.

  8. Exact capacity analysis of multihop transmission over amplify-and-forward relay fading channels

    KAUST Repository

    Yilmaz, Ferkan

    2010-09-01

    In this paper, we propose an analytical framework on the exact computation of the average capacity of multihop transmission over amplify-and-forward relay fading channels. Our approach relies on the algebraic combination of Mellin and Laplace transforms to obtain exact single integral expressions which can be easily computed by Gauss-Chebyshev Quadrature (GCQ) rule. As such, the derived results are a convenient tool to analyze the average capacity of multihop transmission over amplify-and-forward relay fading channels. As an application of the analytical framework on the exact computation of the average capacity of multihop transmission, some examples are accentuated for generalized Nakagami-m fading channels. Numerical and simulation results, performed to verify the correctness of the proposed formulation, are in perfect agreement. ©2010 IEEE.

  9. Correlating Anatomy and Function with Gene Expression in Individual Neurons by Combining in Vivo Labeling, Patch Clamp, and Single Cell RNA-seq

    Directory of Open Access Journals (Sweden)

    Carsten K. Pfeffer

    2017-11-01

    Full Text Available The classification of neurons into distinct types is an ongoing effort aimed at revealing and understanding the diversity of the components of the nervous system. Recently available methods allow us to determine the gene expression pattern of individual neurons in the mammalian cerebral cortex to generate powerful categorization schemes. For a thorough understanding of neuronal diversity such genetic categorization schemes need to be combined with traditional classification parameters like position, axonal projection or response properties to sensory stimulation. Here we describe a method to link the gene expression of individual neurons with their position, axonal projection, or sensory response properties. Neurons are labeled in vivo based on their anatomical or functional properties and, using patch clamp pipettes, their RNA individually harvested in vitro for RNAseq. We validate the methodology using multiple established molecularly and anatomically distinct cell populations and explore molecular differences between uncharacterized neurons in mouse visual cortex. Gene expression patterns between L5 neurons projecting to frontal or contralateral cortex are distinct while L2 neurons differing in position, projection, or function are molecularly similar. With this method we can determine the genetic expression pattern of functionally and anatomically identified individual neurons.

  10. Relay protection coordination with generator capability curve, excitation system limiters and power system relay protections settings

    OpenAIRE

    Buha Danilo; Buha Boško; Jačić Dušan; Gligorov Saša; Božilov Marko; Marinković Savo; Milosavljević Srđan

    2016-01-01

    The relay protection settings performed in the largest thermal powerplant (TE "Nikola Tesla B") are reffered and explained in this paper. The first calculation step is related to the coordination of the maximum stator current limiter settings, the overcurrent protection with inverse characteristics settings and the permitted overload of the generator stator B1. In the second calculation step the settings of impedance generator protection are determined, and the methods and criteria according ...

  11. CERN Relay Race | 5 June | Get ready!

    CERN Multimedia

    CERN Medical Service

    2014-01-01

    In anticipation of the CERN relay race, the Medical Service would like to remind all participants that preparing for this sporting activity is essential - even though it is a short event.   Progressive and regular training. Adequate nutrition and hydration. Advice and information is available at the infirmary in Building 57. Everyone should adapt their physical activity to match their fitness levels, bearing in mind that the aim of this race is not necessarily to achieve great success but to participate in a collective sporting event. In the framework of the "Move! Eat better" campaign and for the third successive year, a 2.4 km route is open to walkers, both beginners and experts. Before, during and after this event, test yourself with a pedometer, available from the CERN infirmary! 

  12. Testing of high-impedance fault relays

    Energy Technology Data Exchange (ETDEWEB)

    Nagpal, M. [Powertech Labs., Inc., Surrey, BC (Canada)

    1995-11-01

    A test system and protocol was developed for the testing of high-impedance fault (HIF) detection devices. A technique was established for point-by-point addition of fault and load currents, the resultant was used for testing the performance of the devices in detecting HIFs in the presence of load current. The system used digitized data from recorded faults and normal currents to generate analog test signals for high-impedance fault detection relays. A test apparatus was built with a 10 kHz band-width and playback duration of 30 minutes on 6 output channels for testing purposes. Three devices which have recently become available were tested and their performance was evaluated based on their respective test results.

  13. Generalized routing protocols for multihop relay networks

    KAUST Repository

    Khan, Fahd Ahmed

    2011-07-01

    Performance of multihop cooperative networks depends on the routing protocols employed. In this paper we propose the last-n-hop selection protocol, the dual path protocol, the forward-backward last-n-hop selection protocol and the forward-backward dual path protocol for the routing of data through multihop relay networks. The average symbol error probability performance of the schemes is analysed by simulations. It is shown that close to optimal performance can be achieved by using the last-n-hop selection protocol and its forward-backward variant. Furthermore we also compute the complexity of the protocols in terms of number of channel state information required and the number of comparisons required for routing the signal through the network. © 2011 IEEE.

  14. Large Efficient Intelligent Heating Relay Station System

    Science.gov (United States)

    Wu, C. Z.; Wei, X. G.; Wu, M. Q.

    2017-12-01

    The design of large efficient intelligent heating relay station system aims at the improvement of the existing heating system in our country, such as low heating efficiency, waste of energy and serious pollution, and the control still depends on the artificial problem. In this design, we first improve the existing plate heat exchanger. Secondly, the ATM89C51 is used to control the whole system and realize the intelligent control. The detection part is using the PT100 temperature sensor, pressure sensor, turbine flowmeter, heating temperature, detection of user end liquid flow, hydraulic, and real-time feedback, feedback signal to the microcontroller through the heating for users to adjust, realize the whole system more efficient, intelligent and energy-saving.

  15. ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo.

    Science.gov (United States)

    Spencer, Brian; Emadi, Sharareh; Desplats, Paula; Eleuteri, Simona; Michael, Sarah; Kosberg, Kori; Shen, Jay; Rockenstein, Edward; Patrick, Christina; Adame, Anthony; Gonzalez, Tania; Sierks, Michael; Masliah, Eliezer

    2014-10-01

    Parkinson's disease and dementia with Lewy bodies are neurodegenerative disorders characterized by accumulation of α-synuclein (α-syn). Recently, single-chain fragment variables (scFVs) have been developed against individual conformational species of α-syn. Unlike more traditional monoclonal antibodies, these scFVs will not activate or be endocytosed by Fc receptors. For this study, we investigated an scFV directed against oligomeric α-syn fused to the LDL receptor-binding domain from apolipoprotein B (apoB). The modified scFV showed enhanced brain penetration and was imported into neuronal cells through the endosomal sorting complex required for transport (ESCRT) pathway, leading to lysosomal degradation of α-syn aggregates. Further analysis showed that the scFV was effective at ameliorating neurodegenerative pathology and behavioral deficits observed in the mouse model of dementia with Lewy bodies/Parkinson's disease. Thus, the apoB modification had the effect of both increasing accumulation of the scFV in the brain and directing scFV/α-syn complexes for degradation through the ESCRT pathway, leading to improved therapeutic potential of immunotherapy.

  16. Distance relay performance in future converter dominated power systems

    DEFF Research Database (Denmark)

    Sarkar, Moumita; Jia, Jundi; Yang, Guangya

    2017-01-01

    Increasing penetration of converter-based generations in power system has led to new system challenges. Short circuit power response from converter-based generations is different from that of traditional synchronous generators. Power electronic converters can be designed for over-current only up ...... of converter controls on fault current response of converter-based generations is also investigated. Index Terms—Converter control, distance relays, power system protection, system modelling....... to 1.1-1.25 times of its nominal value. Low availability of short circuit power can cause many challenges such as misoperation of distance relays. The aim of this paper is to investigate the effect of converter dominated systems on performance of distance relays. Backup functionality of the distance...... relay is major concern as miscoordination of backup relays in case of cascading faults can lead to severe stress in system, which can develop into blackout. In this paper, response of relays in traditional system is compared with response of relays in low short-circuit-current power systems. Impact...

  17. Mobile User Connectivity in Relay-Assisted Visible Light Communications

    Directory of Open Access Journals (Sweden)

    Petr Pešek

    2018-04-01

    Full Text Available In this paper, we investigate relay-assisted visible light communications (VLC where a mobile user acts as a relay and forwards data from a transmitter to the end mobile user. We analyse the utilization of the amplify-and-forward (AF and decode-and-forward (DF relaying schemes. The focus of the paper is on analysis of the behavior of the mobile user acting as a relay while considering a realistic locations of the receivers and transmitters on a standard mobile phone, more specifically with two photodetectors on both sides of a mobile phone and a transmitting LED array located upright. We also investigate dependency of the bit error rate (BER performance on the azimuth and elevation angles of the mobile relay device within a typical office environment. We provide a new analytical description of BER for AF and DF-based relays in VLC. In addition we compare AF and DF-based systems and show that DF offers a marginal improvement in the coverage area with a BER < 10–3 and a data rate of 100 Mb/s. Numerical results also illustrate that relay-based systems offer a significant improvement in terms of the coverage compared to direct non-line of sight VLC links.

  18. Distributed stability control using intelligent voltage-margin relay

    Energy Technology Data Exchange (ETDEWEB)

    Wiszniewski, A.; Rebizant, W. [Wroclaw Univ. of Technology (Poland); Klimek, A. [Powertech Labs Inc., Surrey, BC (Canada)

    2010-07-01

    This paper presented an intelligent relay that operates if the load to source impedance ratio decreases to a level that is dangerously close to the stability limit, which leads to power system blackouts. The intelligent voltage-margin/difference relay installed at receiving substations automatically initiates action if the voltage stability margin drops to a dangerously low level. The relay decides if the tap changing devices are to be blocked and if under-voltage load shedding should be initiated, thereby mitigating an evolving instability. The intelligent relay has two levels of operation. At the first stage, which corresponds to the higher load to source impedance ratio, the relay initiates blocking of the tap changer. At the second stage, corresponding to the lower source to load impedance ratio, load shedding is initiated. The relay operates when the load to source impedance ratio reaches a certain predetermined level, but it does not depend either on the level of the source voltage or on the difference of source and load impedance phase angles. The algorithm for the relay is relatively simple and uses only locally available signals. Consequently, the transformer is well controlled to eliminate the cases of voltage instability. 6 refs., 7 figs.

  19. Admission Control Threshold in Cellular Relay Networks with Power Adjustment

    Directory of Open Access Journals (Sweden)

    Lee Ki-Dong

    2009-01-01

    Full Text Available Abstract In the cellular network with relays, the mobile station can benefit from both coverage extension and capacity enhancement. However, the operation complexity increases as the number of relays grows up. Furthermore, in the cellular network with cooperative relays, it is even more complex because of an increased dimension of signal-to-noise ratios (SNRs formed in the cooperative wireless transmission links. In this paper, we propose a new method for admission capacity planning in a cellular network using a cooperative relaying mechanism called decode-and-forward. We mathematically formulate the dropping ratio using the randomness of "channel gain." With this, we formulate an admission threshold planning problem as a simple optimization problem, where we maximize the accommodation capacity (in number of connections subject to two types of constraints. (1 A constraint that the sum of the transmit powers of the source node and relay node is upper-bounded where both nodes can jointly adjust the transmit power. (2 A constraint that the dropping ratio is upper-bounded by a certain threshold value. The simplicity of the problem formulation facilitates its solution in real-time. We believe that the proposed planning method can provide an attractive guideline for dimensioning a cellular relay network with cooperative relays.

  20. Two-Hop Secure Communication Using an Untrusted Relay

    Directory of Open Access Journals (Sweden)

    Xiang He

    2009-01-01

    Full Text Available We consider a source-destination pair that can only communicate through an untrusted intermediate relay node. The intermediate node is willing to employ a designated relaying scheme to facilitate reliable communication between the source and the destination. Yet, the information it relays needs to be kept secret from it. In this two-hop communication scenario, where the use of the untrusted relay node is essential, we find that a positive secrecy rate is achievable. The center piece of the achievability scheme is the help provided by either the destination node with transmission capability, or an external “good samaritan” node. In either case, the helper performs cooperative jamming that confuses the eavesdropping relay and disables it from being able to decipher what it is relaying. We next derive an upper bound on the secrecy rate for this system. We observe that the gap between the upper bound and the achievable rate vanishes as the power of the relay node goes to infinity. Overall, the paper presents a case for intentional interference, that is, cooperative jamming, as an enabler for secure communication.

  1. Multistability and hidden attractors in a relay system with hysteresis

    DEFF Research Database (Denmark)

    Zhusubaliyev, Zhanybai T.; Mosekilde, Erik; Rubanov, Vasily G.

    2015-01-01

    with the neighborhood of that cycle. We show how the equilibrium point of a relay system disappears in a boundary-equilibrium bifurcation as the system enters the region of autonomous switching dynamics and demonstrate experimentally how a relay system can exhibit large amplitude chaotic oscillations at high values...... of the supply voltage. By investigating a four-dimensional model of the experimental relay system we finally show how a variety of hidden periodic, quasiperiodic and chaotic attractors arise, transform and disappear through different bifurcations. (C) 2015 Elsevier B.V. All rights reserved....

  2. On Buffer-Aided Multiple-Access Relay Channel

    DEFF Research Database (Denmark)

    Liu, Rongkuan; Popovski, Petar; Wang, Gang

    2016-01-01

    This letter treats uplink scenario where M user equipments (UEs) send to a base station (BS), possibly via a common relay station (RS) that is equipped with a buffer. This is a multiple-access relay channel aided by a buffer. We devise a protocol in which the transmission mode is selected...... entirely at the BS, while simultaneously a number of UEs sends new messages to the BS. The results show that the adaptive selection of direct and buffer-aided relay transmissions leads to significant average throughput gains....

  3. The influence of single neuron dynamics and network topology on time delay-induced multiple synchronous behaviors in inhibitory coupled network

    International Nuclear Information System (INIS)

    Zhao, Zhiguo; Gu, Huaguang

    2015-01-01

    Highlights: • Time delay-induced multiple synchronous behaviors was simulated in neuronal networks. • Multiple behaviors appear at time delays shorter than a bursting period of neurons. • The more spikes per burst of bursting, the more synchronous regions of time delay. • From regular to random via small-world networks, synchronous degree becomes weak. • An interpretation of the multiple behaviors and the influence of network are provided. - Abstract: Time delay induced-multiple synchronous behaviors are simulated in neuronal network composed of many inhibitory neurons and appear at different time delays shorter than a period of endogenous bursting of individual neurons. It is different from previous investigations wherein only one of multiple synchronous behaviors appears at time delay shorter than a period of endogenous firing and others appear at time delay longer than the period duration. The bursting patterns of the synchronous behaviors are identified based on the dynamics of an individual neuron stimulated by a signal similar to the inhibitory coupling current, which is applied at the decaying branch of a spike and suitable phase within the quiescent state of the endogenous bursting. If a burst of endogenous bursting contains more spikes, the synchronous behaviors appear at more regions of time delay. As the coupling strength increases, the multiple synchronous behaviors appear in a sequence because the different threshold of coupling current or strength is needed to achieve synchronous behaviors. From regular, to small-world, and to random networks, synchronous degree of the multiple synchronous behaviors becomes weak, and synchronous bursting patterns with lower spikes per burst disappear, which is properly interpreted by the difference of coupling current between neurons induced by different degree and the high threshold of coupling current to achieve synchronization for the absent synchronous bursting patterns. The results of the influence of

  4. BigNeuron: Large-scale 3D Neuron Reconstruction from Optical Microscopy Images

    OpenAIRE

    Peng, Hanchuan; Hawrylycz, Michael; Roskams, Jane; Hill, Sean; Spruston, Nelson; Meijering, Erik; Ascoli, Giorgio A.

    2015-01-01

    textabstractUnderstanding the structure of single neurons is critical for understanding how they function within neural circuits. BigNeuron is a new community effort that combines modern bioimaging informatics, recent leaps in labeling and microscopy, and the widely recognized need for openness and standardization to provide a community resource for automated reconstruction of dendritic and axonal morphology of single neurons. Understanding the structure of single neurons is critical for unde...

  5. Comparison of Channel Estimation Protocols for Coherent AF Relaying Networks in the Presence of Additive Noise and LO Phase Noise

    Directory of Open Access Journals (Sweden)

    Stefan Berger

    2010-01-01

    Full Text Available Channel estimation protocols for wireless two-hop networks with amplify-and-forward (AF relays are compared. We consider multiuser relaying networks, where the gain factors are chosen such that the signals from all relays add up coherently at the destinations. While the destinations require channel knowledge in order to decode, our focus lies on the channel estimates that are used to calculate the relay gains. Since knowledge of the compound two-hop channels is generally not sufficient to do this, the protocols considered here measure all single-hop coefficients in the network. We start from the observation that the direction in which the channels are measured determines (1 the number of channel uses required to estimate all coefficient and (2 the need for global carrier phase reference. Four protocols are identified that differ in the direction in which the first-hop and the second-hop channels are measured. We derive a sensible measure for the accuracy of the channel estimates in the presence of additive noise and phase noise and compare the protocols based on this measure. Finally, we provide a quantitative performance comparison for a simple single-user application example. It is important to note that the results can be used to compare the channel estimation protocols for any two-hop network configuration and gain allocation scheme.

  6. Impact of Apparent Reactance Injected by TCSR on Distance Relay in Presence Phase to Earth Fault

    Directory of Open Access Journals (Sweden)

    Mohamed Zellagui

    2013-01-01

    Full Text Available This research paper presents the impact study of apparent reactance injected by series Flexible AC Transmission System (FACTS i.e. Thyristor Controlled Series Reactor (TCSR on the measured impedance of a 400 kV single electrical transmission line in the presence of phase to earth fault with fault resistance. The study deals with an electrical transmission line of Eastern Algerian transmission networks at Group Sonelgaz (Algerian Company of Electrical compensated by TCSR connected at midpoint of the transmission line. This compensator used to inject voltage and reactive power is controlled by TCSR. The simulations results investigate the three impacts of the apparent reactance injected by TCSR (XTCSR on transmission line protected by distance relay protection. The impacts concern the active and reactive power, the line impedance (reactance and resistance, and the short circuit parameters (symmetrical currents, line currents, symmetrical voltages and line voltages as well as the measured impedance by relay (resistance and reactance in the presence of earth fault These impacts are investigated in order to improve the performances of distance relay protection. More the impact of XTCSR by three TCSR for cases studies is presented.

  7. Beamforming-Based Physical Layer Network Coding for Non-Regenerative Multi-Way Relaying

    Directory of Open Access Journals (Sweden)

    Klein Anja

    2010-01-01

    Full Text Available We propose non-regenerative multi-way relaying where a half-duplex multi-antenna relay station (RS assists multiple single-antenna nodes to communicate with each other. The required number of communication phases is equal to the number of the nodes, N. There are only one multiple-access phase, where the nodes transmit simultaneously to the RS, and broadcast (BC phases. Two transmission methods for the BC phases are proposed, namely, multiplexing transmission and analog network coded transmission. The latter is a cooperation method between the RS and the nodes to manage the interference in the network. Assuming that perfect channel state information is available, the RS performs transceive beamforming to the received signals and transmits simultaneously to all nodes in each BC phase. We address the optimum transceive beamforming maximising the sum rate of non-regenerative multi-way relaying. Due to the nonconvexity of the optimization problem, we propose suboptimum but practical signal processing schemes. For multiplexing transmission, we propose suboptimum schemes based on zero forcing, minimising the mean square error, and maximising the signal to noise ratio. For analog network coded transmission, we propose suboptimum schemes based on matched filtering and semidefinite relaxation of maximising the minimum signal to noise ratio. It is shown that analog network coded transmission outperforms multiplexing transmission.

  8. Cross-Layer Design for Two-Way Relaying Networks with Multiple Antennas

    Directory of Open Access Journals (Sweden)

    zhuo wu

    2015-10-01

    Full Text Available In this paper, we developed a cross-layer design for two-way relaying (TWR networks with multiple antennas, where two single antenna source nodes exchange information with the aid of one multiple antenna relay node. The proposed cross-layer design considers adaptive modulation (AM and space-time block coding (STBC at the physical layer with an automatic repeat request (ARQ protocol at the data link layer, in order to maximize the spectral efficiency under specific delay and packet error ratio (PER constraints. An MMSE-interference cancellation (IC receiver is employed at the relay node, to remove the interference in the fist phase of the TWR transmission. The transmission mode is updated for each phase of the TWR transmission on a frame-by-frame basis, to match the time-varying channel conditions and exploit the system performance and throughput gain. Simulation results show that retransmission at the data link layer could alleviate rigorous error-control requirements at the physical layer, and thereby allows higher data transmission. As a result, cross-layer design helps to achieve considerable system spectral efficiency gain for TWR networks, compared to those without cross-layer design.

  9. Relay Selections for Security and Reliability in Mobile Communication Networks over Nakagami-m Fading Channels

    Directory of Open Access Journals (Sweden)

    Hongji Huang

    2017-01-01

    Full Text Available This paper studies the relay selection schemes in mobile communication system over Nakagami-m channel. To make efficient use of licensed spectrum, both single relay selection (SRS scheme and multirelays selection (MRS scheme over the Nakagami-m channel are proposed. Also, the intercept probability (IP and outage probability (OP of the proposed SRS and MRS for the communication links depending on realistic spectrum sensing are derived. Furthermore, this paper assesses the manifestation of conventional direct transmission scheme to compare with the proposed SRS and MRS ones based on the Nakagami-m channel, and the security-reliability trade-off (SRT performance of the proposed schemes and the conventional schemes is well investigated. Additionally, the SRT of the proposed SRS and MRS schemes is demonstrated better than that of direct transmission scheme over the Nakagami-m channel, which can protect the communication transmissions against eavesdropping attacks. Additionally, simulation results show that our proposed relay selection schemes achieve better SRT performance than that of conventional direct transmission over the Nakagami-m channel.

  10. Orexins excite ventrolateral geniculate nucleus neurons predominantly via OX2 receptors.

    Science.gov (United States)

    Chrobok, Lukasz; Palus, Katarzyna; Lewandowski, Marian Henryk

    2016-04-01

    Orexins/hypocretins are two neuropeptides that influence many behaviours, such as feeding, sleep or arousal. Orexin A/hypocretin-1 (OXA) and orexin B/hypocretin-2 (OXB) bind to two metabotropic receptors, named the OX1 and OX2 receptors. The lateral geniculate complex of the thalamus is one of the many targets of orexinergic fibres derived from the lateral hypothalamus, although the impact of orexins on the ventrolateral geniculate nucleus (VLG) is poorly understood. The VLG, an important relay station of the subcortical visual system, is implicated in visuomotor and/or circadian processes. Therefore, in this study we evaluated the effects of orexins on single VLG neurons using a patch-clamp technique in vitro. Surprisingly, orexins depolarised the majority of the recorded neurons regardless of their localisation in the borders of the VLG. In addition, data presented in this article show that neurons synthesising NO were also affected by OXA. Moreover, immunohistochemical staining of OXB revealed the moderate density of orexinergic fibbers in the VLG. Our study using specific orexin receptor antagonists suggests that the OX2 receptor has a dominant role in the observed effects of OXA. To our knowledge, this article is the first to show orexinergic modulation of the VLG. These findings strengthen the postulated link between orexins and the circadian system, and propose a new role of these neuropeptides in the modulation of visuomotor functions. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Olfactory map formation in the Drosophila brain: genetic specificity and neuronal variability.

    Science.gov (United States)

    Brochtrup, Anna; Hummel, Thomas

    2011-02-01

    The development of the Drosophila olfactory system is a striking example of how genetic programs specify a large number of different neuron types and assemble them into functional circuits. To ensure precise odorant perception, each sensory neuron has to not only select a single olfactory receptor (OR) type out of a large genomic repertoire but also segregate its synaptic connections in the brain according to the OR class identity. Specification and patterning of second-order interneurons in the olfactory brain center occur largely independent of sensory input, followed by a precise point-to-point matching of sensory and relay neurons. Here we describe recent progress in the understanding of how cell-intrinsic differentiation programs and context-dependent cellular interactions generate a stereotyped sensory map in the Drosophila brain. Recent findings revealed an astonishing morphological diversity among members of the same interneuron class, suggesting an unexpected variability in local microcircuits involved in insect sensory processing. Copyright © 2010 Elsevier Ltd. All rights reserved.

  12. Multiple relay selection for delay-limited applications

    KAUST Repository

    Alsharoa, Ahmad M.; Abediseid, Walid; Alouini, Mohamed-Slim

    2013-01-01

    A multiple relay selection system model that implements the decode-and-forward mode is investigated. All communication nodes are assumed to be equipped by multiple antennas. Furthermore, lattices space-time coded multiple-input multiple-output half

  13. relay coordination in the protection of radially-connected power

    African Journals Online (AJOL)

    ... PROTECTION OF. RADIALLY-CONNECTED POWER SYSTEM NETWORK ... Protective relays detect intolerable or unwanted conditions within an assigned area, and then trip or open one ... time, and current transformer ratio errors. 2.2.1.

  14. Outage analysis for underlay cognitive networks using incremental regenerative relaying

    KAUST Repository

    Tourki, Kamel; Qaraqe, Khalid A.; Alouini, Mohamed-Slim

    2013-01-01

    Cooperative relay technology has recently been introduced into cognitive radio (CR) networks to enhance the network capacity, scalability, and reliability of end-to-end communication. In this paper, we investigate an underlay cognitive network where

  15. New results on performance analysis of opportunistic regenerative relaying

    KAUST Repository

    Tourki, Kamel

    2013-12-01

    In this paper, we investigate an opportunistic relaying scheme where the selected relay assists the source-destination (direct) communication. In our study, we consider a regenerative opportunistic relaying scheme in which the direct path may be unusable, and takes into account the effect of the possible erroneously detected and transmitted data at the selected relay. We first derive the signal-to-noise (SNR) statistics for each hop, which are used to determine accurate closed form expressions for end-to-end bit-error rate (BER) of binary phase-shift keying (BPSK) modulation and end-to-end outage probability for a transmission rate R over Rayleigh fading channels. Furthermore, we evaluate the asymptotical performance and deduce the diversity order. Finally, we validate our analysis by showing that performance simulation results coincide with our analytical results over linear network architecture. © 2013 Elsevier B.V.

  16. Error-rate performance analysis of opportunistic regenerative relaying

    KAUST Repository

    Tourki, Kamel

    2011-09-01

    In this paper, we investigate an opportunistic relaying scheme where the selected relay assists the source-destination (direct) communication. In our study, we consider a regenerative opportunistic relaying scheme in which the direct path can be considered unusable, and takes into account the effect of the possible erroneously detected and transmitted data at the best relay. We first derive the exact statistics of each hop, in terms of probability density function (PDF). Then, the PDFs are used to determine accurate closed form expressions for end-to-end bit-error rate (BER) of binary phase-shift keying (BPSK) modulation where the detector may use maximum ration combining (MRC) or selection combining (SC). Finally, we validate our analysis by showing that performance simulation results coincide with our analytical results over linear network (LN) architecture and considering Rayleigh fading channels. © 2011 IEEE.

  17. Efficient incremental relaying for packet transmission over fading channels

    KAUST Repository

    Fareed, Muhammad Mehboob; Alouini, Mohamed-Slim; Yang, Hongchuan

    2014-01-01

    In this paper, we propose a novel relaying scheme for packet transmission over fading channels, which improves the spectral efficiency of cooperative diversity systems by utilizing limited feedback from the destination. Our scheme capitalizes

  18. Reliable quantum communication over a quantum relay channel

    Energy Technology Data Exchange (ETDEWEB)

    Gyongyosi, Laszlo, E-mail: gyongyosi@hit.bme.hu [Quantum Technologies Laboratory, Department of Telecommunications, Budapest University of Technology and Economics, 2 Magyar tudosok krt, Budapest, H-1117, Hungary and Information Systems Research Group, Mathematics and Natural Sciences, Hungarian Ac (Hungary); Imre, Sandor [Quantum Technologies Laboratory, Department of Telecommunications, Budapest University of Technology and Economics, 2 Magyar tudosok krt, Budapest, H-1117 (Hungary)

    2014-12-04

    We show that reliable quantum communication over an unreliable quantum relay channels is possible. The coding scheme combines the results on the superadditivity of quantum channels and the efficient quantum coding approaches.

  19. SIMULASI SISTEM KELISTRIKAN KAMAR HOTEL MENGGUNAKAN SMART RELAY

    Directory of Open Access Journals (Sweden)

    I Nyoman Sukarma

    2018-03-01

    Full Text Available Fungsi dari alat key tag atau hotel switch atau key card adalah memutus atau menyambungkan aliran listrik ke dalam suatu area tertentu atau ruang. Key tag memiliki peran penting pada kamar hotel untuk mencegah pemborosan energi pada saat kamar hotel tidak berpenghuni atau belum tersewakan. Untuk itu, penulis merancang simulasi sistem kelistrikan pada kamar hotel yang dikontrol dengan smart relay. Pada simulasi ini digunakan smart relay Zelio Logic buatan Schneider Electric. Pemrograman smart relay ini menggunakan ladder diagram yang disusun menggunakan perangkat lunak ZelioSoft2 dari Schneider Electric. Smart relay menerima sinyal masukan dari sensor, key tag dan sakelar. Sinyal masukan tersebut selanjutnya diproses agar lampu, kotak-kontak, exhaust fan, dan AC (Air Conditioner pada kamar hotel dapat bekerja.

  20. Spreading Sequence System for Full Connectivity Relay Network

    Science.gov (United States)

    Kwon, Hyuck M. (Inventor); Yang, Jie (Inventor); Pham, Khanh D. (Inventor)

    2018-01-01

    Fully connected uplink and downlink fully connected relay network systems using pseudo-noise spreading and despreading sequences subjected to maximizing the signal-to-interference-plus-noise ratio. The relay network systems comprise one or more transmitting units, relays, and receiving units connected via a communication network. The transmitting units, relays, and receiving units each may include a computer for performing the methods and steps described herein and transceivers for transmitting and/or receiving signals. The computer encodes and/or decodes communication signals via optimum adaptive PN sequences found by employing Cholesky decompositions and singular value decompositions (SVD). The PN sequences employ channel state information (CSI) to more effectively and more securely computing the optimal sequences.

  1. Four-Way Relaying in Wireless Cellular Systems

    DEFF Research Database (Denmark)

    Liu, Huaping; Popovski, Petar; De Carvalho, Elisabeth

    2013-01-01

    Two-way relaying in wireless systems has initiated a large research effort during the past few years. Nevertheless, it represents only a specific traffic pattern and it is of interest to investigate other traffic patterns where such a simultaneous processing of information flows can bring...... performance advantage. In this paper we consider a \\emph{four-way relaying} scenario, where each of the two Mobile Stations (MSs) has a two-way connection to the same Base Station (BS), while each connection is through a dedicated Relay Station (RS). The RSs are placed in such a way that one RS...... of the new scheme for Decode-and-Forward (DF) operational model for the RS. We compare the performance with a state-of-the-art reference scheme, based on two-way relaying with DF. The results indicate that the achievable rate regions are significantly enlarged for the new scheme....

  2. The distribution choice for the threshold of solid state relay

    International Nuclear Information System (INIS)

    Sun Beiyun; Zhou Hui; Cheng Xiangyue; Mao Congguang

    2009-01-01

    Either normal distribution or Weibull distribution can be accepted as sample distribution of the threshold of solid state relay. By goodness-of-fit method, bootstrap method and Bayesian method, the Weibull distribution is chosen later. (authors)

  3. The sequence relay selection strategy based on stochastic dynamic programming

    Science.gov (United States)

    Zhu, Rui; Chen, Xihao; Huang, Yangchao

    2017-07-01

    Relay-assisted (RA) network with relay node selection is a kind of effective method to improve the channel capacity and convergence performance. However, most of the existing researches about the relay selection did not consider the statically channel state information and the selection cost. This shortage limited the performance and application of RA network in practical scenarios. In order to overcome this drawback, a sequence relay selection strategy (SRSS) was proposed. And the performance upper bound of SRSS was also analyzed in this paper. Furthermore, in order to make SRSS more practical, a novel threshold determination algorithm based on the stochastic dynamic program (SDP) was given to work with SRSS. Numerical results are also presented to exhibit the performance of SRSS with SDP.

  4. Overlay cognitive radio systems with adaptive two-way relaying

    KAUST Repository

    Hyadi, Amal

    2013-12-01

    In this paper, we propose a spectrum sharing mechanism with a two-phase two-way relaying protocol for an overlay cognitive network. The system comprises two primary users (PUs) and two secondary users (SUs). One of the SUs acts as a relay for the PUs and gains spectrum sharing as long as he respects outage probability constraints of the primary system. Moreover, we consider that the relaying node performs an optimal power allocation scheme that minimizes the outage performance of the secondary receiver. Closed form expressions for the outage probability are derived for the cases of Decode-and-Forward (DF), Amplify-and-Forward (AF), and adaptive relaying. Numerical simulations are presented to illustrate and compare the obtained results. © 2013 IEEE.

  5. Ultra Reliable Short Message Relaying with Wireless Power Transfer

    OpenAIRE

    López, Onel L. Alcaraz; Alves, Hirley; Souza, Richard Demo; Fernández, Evelio Martín García

    2017-01-01

    Abstract We consider a dual-hop wireless network where an energy constrained relay node first harvests energy through the received radio-frequency signal from the source, and then uses the harvested energy to forward the source’s information to the destination node. The throughput and delay metrics are investigated for a decode-and-forward relaying mechanism at finite blocklength regime and delay-limited transmission mode. We consider ultra-reliable communication scenarios under discussio...

  6. Impact Analysis of Electrical Current Characteristics in Relay Function for Electrical and Electronic Protection

    International Nuclear Information System (INIS)

    Syirrazie Che Soh; Harzawadi Hasim

    2013-01-01

    This paper is to study effect of electrical current on relay reaction, which has coil and switch inside the relay. An analysis on the electrical current will be conducted to determine current limitation for relay activation purpose. The result of analysis showing that current characteristic of relay and applied load will present their affect to the relay function performance. Finding from this result will bring the idea to develop a suitable design circuit for electrical and electronic protection. (author)

  7. Optimal Coordination of Distance and Directional Overcurrent Relays Considering Different Network Topologies

    OpenAIRE

    Y. Damchi; J. Sadeh; H. Rajabi Mashhadi

    2015-01-01

    Most studies in relay coordination have focused solely on coordination of overcurrent relays while distance relays are used as the main protection of transmission lines. Since, simultaneous coordination of these two types of relays can provide a better protection, in this paper, a new approach is proposed for simultaneous coordination of distance and directional overcurrent relays (D&DOCRs). Also, pursued by most of the previously published studies, the settings of D&DOCRs are usually determi...

  8. Adaptive settings of distance relay for MOV-protected series compensated line with distributed capacitance considering wind power

    Science.gov (United States)

    Sivov, Oleg Viktorovich

    Series compensated lines are protected from overvoltage by metal-oxide-varistors (MOVs) connected in parallel with the capacitor bank. The nonlinear characteristics of MOV devices add complexity to fault analysis and distance protection operation. During faults, the impedance of the line is modified by an equivalent impedance of the parallel MOV/capacitor circuit, which affects the distance protection. The intermittent wind generation introduces additional complexity to the system performance and distance protection. Wind variation affects the fault current level and equivalent MOV/capacitor impedance during a fault, and hence the distance relay operation. This thesis studies the impact of the intermittent wind power generation on the operation of MOV during faults. For the purpose of simulation, an equivalent wind farm model is proposed to generate a wind generation profile using wind farm generation from California independent system operator (ISO) as a guide for wind power variation to perform the study. The IEEE 12-bus test system is modified to include MOV-protected series capacitor and the equivalent wind farm model. The modified test system is simulated in the MATLAB/Simulink environment. The study has been achieved considering three phase and single line to ground (SLG) faults on the series compensated line to show the effect of wind variation on the MOV operation. This thesis proposes an adaptive setting method for the mho relay distance protection of series compensated line considering effects of wind power variation and MOV operation. The distributed parameters of a transmission line are taken into account to avoid overreaching and underreaching of distance relays. The study shows that variable wind power affects system power flow and fault current in the compensated line during a fault which affects the operation of MOVs for different fault conditions. The equivalent per-phase impedance of the MOV/capacitor circuit has an effect on the system operation

  9. Modeling and Simulation of Out of Step Blocking Relay for

    Directory of Open Access Journals (Sweden)

    Ahmed A. Al Adwani

    2013-05-01

    Full Text Available  This paper investigates a power swing effect on a distance protection relay performance installed on (HV/EHV transmission line as well as power system stability. A conventional distance relay can’t properly operate under transient stability conditions; therefore, it cause mol-operation, and it will adversely impact on its trip signals. To overcome this problem, the Out Of Step (OOS relay has modeled and simulated to joint with distance relay to supervise and control on its trip signals response. The setting characteristics technique of the OOS based on concentric polygons scheme method to detect power swing under transient stability situation.         This study ia a modeling and simulating using (Maltab\\ Simulink software. A Two relays had been  performed   and  tested  with  two equivalents network connected to ends.      The results of this study showed an activity and reliability of this way to control the distance relay response under a transient stability conditions and it indicated the possibility to find out faults which may occur at period of power swing

  10. PERFORMANCE ANALYSIS OF COOPERATION SCHEMES IN EAVESDROPPER ASSISTED RELAY CHANNEL

    Directory of Open Access Journals (Sweden)

    Vaibhav Kumar Gupta

    2014-06-01

    Full Text Available The prominence of the wireless communication has been urging the monotonically increasing demand of security and privacy. In wireless systems, the notion of perfect secrecy of information with respect to illegitimate nodes can be ensured via physical layer security (PLS techniques. Unfortunately, they can be made less effective if source- eavesdropper wiretap channel is better than the main source-receiver channel. The various node cooperation schemes can be employed to combat this limitation where a relay node assists the communication to improve the performance significantly. In this paper, a four node wireless communication system consisting of a source, a destination, a relay and an eavesdropper as wire-tapper has been considered. The performance of the traditional cooperation schemes in terms of secrecy rate has been investigated with a different scenario where relay node helps the eavesdropper to deteriorate the secrecy rate. In addition, since legitimate receiver can overhear the transmission of relay, it favours the achievable secrecy rate. We formulate an analytical expression of conditional secrecy outage probability for the investigated system. From the obtained simulation results, it has been observed that secrecy rate is monotonically increases with path loss index. Furthermore, the proper selection of the system parameters leads to enhance the secrecy performance of the system even if relay pertains to degrade the performance. Amplify-and-forward, cooperation, decode-and-Forward, secrecy rate, relay.

  11. Secrecy Capacity of a Class of Orthogonal Relay Eavesdropper Channels

    Directory of Open Access Journals (Sweden)

    Aggarwal Vaneet

    2009-01-01

    Full Text Available The secrecy capacity of relay channels with orthogonal components is studied in the presence of an additional passive eavesdropper node. The relay and destination receive signals from the source on two orthogonal channels such that the destination also receives transmissions from the relay on its channel. The eavesdropper can overhear either one or both of the orthogonal channels. Inner and outer bounds on the secrecy capacity are developed for both the discrete memoryless and the Gaussian channel models. For the discrete memoryless case, the secrecy capacity is shown to be achieved by a partial decode-and-forward (PDF scheme when the eavesdropper can overhear only one of the two orthogonal channels. Two new outer bounds are presented for the Gaussian model using recent capacity results for a Gaussian multiantenna point-to-point channel with a multiantenna eavesdropper. The outer bounds are shown to be tight for two subclasses of channels. The first subclass is one in which the source and relay are clustered, and the eavesdropper receives signals only on the channel from the source and the relay to the destination, for which the PDF strategy is optimal. The second is a subclass in which the source does not transmit to the relay, for which a noise-forwarding strategy is optimal.

  12. Test on digital transmission by carrier relay

    Energy Technology Data Exchange (ETDEWEB)

    Tahara, Taka; Yasuda, Katsuhiko

    1988-09-01

    Though the analog system was applied to the carrier relay system, together with the transmission route, owned/operated by Chugoku Electric Power, accompanying the digitalization of microwave wireless communication, the method to apply the existing analog system signal station unit, to the digital transmission route, came to be required to be discussed. In case of that application, it is feared for a false signal output to be made, with the impossibility of detecting the bit error, characteristic on the digital transmission route. Therefore, by using the microwave wireless communication between Mihara transformation station and Onomichi control station, a transmission test was made on a signal station of phase wave comparison system. As a result, it was known that the false signal output, produced at the detection width of 2ms at present, could be prevented by fixing the detection width to be 1 or 0.5ms and that the lock time ratio could not be maintained at the detection width of 0.5ms. It was further known that the detection width of 1ms only satisfied the condition, which could be secured by the modification only in timer of the bit error detection at signal station. 1 references, 6 figures, 4 tables.

  13. CERN Relay Race: a great success!

    CERN Multimedia

    Staff Association

    2016-01-01

    On Thursday May 19, the traditional relay race was held at CERN, organised jointly by the Running Club and the CERN Staff Association. In spite of the less than optimal weather, the 127 registered teams were not discouraged. Warmed by their efforts on the roads of CERN, the participants were able to withstand the chilly May weather. The start signal for the race was given by our Director General, demonstrating the interest in this event at the highest level of the Organization. Thank you for this much appreciated commitment! Can we hope for next year to see a team from the Directorate in the race? The many spectators who had come to cheer on the runners could also visit the stalls staffed by a few clubs and some of Interfon’s commercial partners. Refreshment and food stands contributed to the friendly atmosphere. The organisation of such an event requires however a substantial investment in order to cover all aspects of logistics, from preparation before the race, to the actual establishment ...

  14. CERN Relay Race: a great success!

    CERN Multimedia

    Staff Association

    2017-01-01

    Thursday 1st June marked the traditional Relay Race at CERN, organised jointly by the Running Club and the CERN Staff Association. Once again, the Race lived up to the expectations and the number of participants came close to last year’s all-time high with no less than 715 entries across different categories! In total 116 teams of 6 runners and 19 walkers completed the course at the Meyrin site in bright sunshine. Congratulations to all of them! Our Director-General gave the starting signal for the Race, demonstrating the interest in this event at the highest level of the Organization. Thank you for this much appreciated commitment! Moreover, a number of very high-level runners came to spice up this 2017 edition. The 1000-meter race was a tight one between Alexandre Roche (top 5 in the “Tour du canton”) and Baptiste Fieux who tore up the race at 2’36 and 2’42 respectively. Baptiste passed the baton to Pierre Baqué, the winner of the 2015 Saint&a...

  15. STUDI ANALISIS KOORDINASI OVER CURRENT RELAY (OCR DAN GROUND FAULT RELAY (GFR PADA RECLOSER DI SALURAN PENYULANG PENEBEL

    Directory of Open Access Journals (Sweden)

    I Dewa Gde Agung Budhi Udiana

    2017-08-01

    Full Text Available Short circuit causing over current problem and can might causing interference of the equipment performance such as distribution transformers also causing widespread disruption occurred. In resolving such interference is required as protection system on the distribution system. Seeing all above is needed coordination between the supporting component of the protection system which is consisted of Over Current Relay (OCR and Ground Fault Relay (GFR. The research was conducted at PT. PLN (Persero South Bali Area Network, INDONESIA on recloser in the feeder line of Penebel. OCR setting between the Relay feeder of Penebel, Recloser Celagi, Recloser Bakisan, and Recloser Benana still less selective, with time value coordination between average security was still less than 0,2 second. Then OCR setting and GFR relay feeder of Penebel, Recloser Celagi, Recloser Bakisan, and Recloser Benana was recommended for re-setting in order to minimize disruption and electric power distribution system to be reliable.

  16. A SDP based design of relay precoding for the power minimization of MIMO AF-relay networks

    KAUST Repository

    Rao, Anlei

    2015-09-11

    Relay precoding for multiple-input and multiple-output (MIMO) relay networks has been approached by either optimizing the efficiency performance with given power consumption constraints or minimizing the power consumption with quality-of-service (QoS) requirements. For the later type design, previous works has worked on minimizing the approximated power consumption. In this paper, exact power consumption for all relays is derived into a quadratic form by diagonalizing the minimum-square error (MSE) matrix, and the relay precoding matrix is designed by optimizing this quadratic form with the help of semidefinite programming (SDP) relaxation. Our simulation results show that such a design can achieve a gain of around 3 dB against the previous design, which optimized the approximated power consumption. © 2015 IEEE.

  17. Cooperative AF Relaying in Spectrum-Sharing Systems: Outage Probability Analysis under Co-Channel Interferences and Relay Selection

    KAUST Repository

    Xia, Minghua; Aissa, Sonia

    2012-01-01

    For cooperative amplify-and-forward (AF) relaying in spectrum-sharing wireless systems, secondary users share spectrum resources originally licensed to primary users to communicate with each other and, thus, the transmit power of secondary

  18. STUDI ANALISIS KOORDINASI OVER CURRENT RELAY (OCR) DAN GROUND FAULT RELAY (GFR) PADA RECLOSER DI SALURAN PENYULANG PENEBEL

    OpenAIRE

    I Dewa Gde Agung Budhi Udiana; I G Dyana Arjana; Tjok Gede Indra Partha

    2017-01-01

    Short circuit causing over current problem and can might causing interference of the equipment performance such as distribution transformers also causing widespread disruption occurred. In resolving such interference is required as protection system on the distribution system. Seeing all above is needed coordination between the supporting component of the protection system which is consisted of Over Current Relay (OCR) and Ground Fault Relay (GFR). The research was conducted at PT. PLN (Perse...

  19. Modified Dynamic Decode-and-Forward Relaying Protocol for Type II Relay in LTE-Advanced and Beyond

    KAUST Repository

    Nam, Sung Sik

    2016-11-29

    In this paper, we propose a modified dynamic decode-and-forward (MoDDF) relaying protocol to meet the critical requirements for user equipment (UE) relays in next-generation cellular systems (e.g., LTE-Advanced and beyond). The proposed MoDDF realizes the fast jump-in relaying and the sequential decoding with an application of random codeset to encoding and re-encoding process at the source and the multiple UE relays, respectively. A subframe-by-subframe decoding based on the accumulated (or buffered) messages is employed to achieve energy, information, or mixed combining. Finally, possible early termination of decoding at the end user can lead to the higher spectral efficiency and more energy saving by reducing the frequency of redundant subframe transmission and decoding. These attractive features eliminate the need of directly exchanging control messages between multiple UE relays and the end user, which is an important prerequisite for the practical UE relay deployment. Copyright: © 2016 Nam et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  20. Modified Dynamic Decode-and-Forward Relaying Protocol for Type II Relay in LTE-Advanced and Beyond

    KAUST Repository

    Nam, Sung Sik; Alouini, Mohamed-Slim; Choi, Seyeong

    2016-01-01

    In this paper, we propose a modified dynamic decode-and-forward (MoDDF) relaying protocol to meet the critical requirements for user equipment (UE) relays in next-generation cellular systems (e.g., LTE-Advanced and beyond). The proposed MoDDF realizes the fast jump-in relaying and the sequential decoding with an application of random codeset to encoding and re-encoding process at the source and the multiple UE relays, respectively. A subframe-by-subframe decoding based on the accumulated (or buffered) messages is employed to achieve energy, information, or mixed combining. Finally, possible early termination of decoding at the end user can lead to the higher spectral efficiency and more energy saving by reducing the frequency of redundant subframe transmission and decoding. These attractive features eliminate the need of directly exchanging control messages between multiple UE relays and the end user, which is an important prerequisite for the practical UE relay deployment. Copyright: © 2016 Nam et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  1. β-Arrestin-2 knockout prevents development of cellular μ-opioid receptor tolerance but does not affect opioid-withdrawal-related adaptations in single PAG neurons.

    Science.gov (United States)

    Connor, M; Bagley, E E; Chieng, B C; Christie, M J

    2015-01-01

    Tolerance to the behavioural effects of morphine is blunted in β-arrestin-2 knockout mice, but opioid withdrawal is largely unaffected. The cellular mechanisms of tolerance have been studied in some neurons from β-arrestin-2 knockouts, but tolerance and withdrawal mechanisms have not been examined at the cellular level in periaqueductal grey (PAG) neurons, which are crucial for central tolerance and withdrawal phenomena. μ-Opioid receptor (MOPr) inhibition of voltage-gated calcium channel currents (ICa ) was examined by patch-clamp recordings from acutely dissociated PAG neurons from wild-type and β-arrestin-2 knockout mice treated chronically with morphine (CMT) or vehicle. Opioid withdrawal-induced activation of GABA transporter type 1 (GAT-1) currents was determined using perforated patch recordings from PAG neurons in brain slices. MOPr inhibition of ICa in PAG neurons was unaffected by β-arrestin-2 deletion. CMT impaired coupling of MOPrs to ICa in PAG neurons from wild-type mice, but this cellular tolerance was not observed in neurons from CMT β-arrestin-2 knockouts. However, β-arrestin-2 knockouts displayed similar opioid-withdrawal-induced activation of GAT-1 currents as wild-type PAG neurons. In β-arrestin-2 knockout mice, the central neurons involved in the anti-nociceptive actions of opioids also fail to develop cellular tolerance to opioids following chronic morphine. The results also provide the first cellular physiological evidence that opioid withdrawal is not disrupted by β-arrestin-2 deletion. However, the unaffected basal sensitivity to opioids in PAG neurons provides further evidence that changes in basal MOPr sensitivity cannot account for the enhanced acute nociceptive response to morphine reported in β-arrestin-2 knockouts. This article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-2. © 2014 The British

  2. Transmit Power Minimization and Base Station Planning for High-Speed Trains with Multiple Moving Relays in OFDMA Systems

    KAUST Repository

    Ghazzai, Hakim

    2016-03-15

    High-speed railway system equipped with moving relay stations placed on the middle of the ceiling of each train wagon is investigated. The users inside the train are served in two hops via the orthogonal frequency-division multiple access (OFDMA) technology. In this work, we first focus on minimizing the total downlink power consumption of the base station (BS) and the moving relays while respecting specific quality of service (QoS) constraints. We first derive the optimal resource allocation solution in terms of OFDMA subcarriers and power allocation using the dual decomposition method. Then, we propose an efficient algorithm based on the Hungarian method in order to find a suboptimal but low complexity solution. Moreover, we propose an OFDMA planning solution for high-speed train by finding the maximal inter-BS distance given the required user data rates in order to perform seamless handover. Our simulation results illustrate the performance of the proposed resource allocation schemes in the case of the 3GPP Long Term Evolution-Advanced (LTE-A) and compare them with previously developed algorithms as well as with the direct transmission scenario. Our results also highlight the significant planning gain obtained thanks to the use of multiple relays instead of the conventional single relay scenario.

  3. Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons.

    Science.gov (United States)

    Machado, Carolina Barcellos; Kanning, Kevin C; Kreis, Patricia; Stevenson, Danielle; Crossley, Martin; Nowak, Magdalena; Iacovino, Michelina; Kyba, Michael; Chambers, David; Blanc, Eric; Lieberam, Ivo

    2014-02-01

    Air breathing is an essential motor function for vertebrates living on land. The rhythm that drives breathing is generated within the central nervous system and relayed via specialised subsets of spinal motor neurons to muscles that regulate lung volume. In mammals, a key respiratory muscle is the diaphragm, which is innervated by motor neurons in the phrenic nucleus. Remarkably, relatively little is known about how this crucial subtype of motor neuron is generated during embryogenesis. Here, we used direct differentiation of motor neurons from mouse embryonic stem cells as a tool to identify genes that direct phrenic neuron identity. We find that three determinants, Pou3f1, Hoxa5 and Notch, act in combination to promote a phrenic neuron molecular identity. We show that Notch signalling induces Pou3f1 in developing motor neurons in vitro and in vivo. This suggests that the phrenic neuron lineage is established through a local source of Notch ligand at mid-cervical levels. Furthermore, we find that the cadherins Pcdh10, which is regulated by Pou3f1 and Hoxa5, and Cdh10, which is controlled by Pou3f1, are both mediators of like-like clustering of motor neuron cell bodies. This specific Pcdh10/Cdh10 activity might provide the means by which phrenic neurons are assembled into a distinct nucleus. Our study provides a framework for understanding how phrenic neuron identity is conferred and will help to generate this rare and inaccessible yet vital neuronal subtype directly from pluripotent stem cells, thus facilitating subsequent functional investigations.

  4. Performance Analysis of Selective Decode-and-Forward Multinode Incremental Relaying with Maximal Ratio Combining

    KAUST Repository

    Hadjtaieb, Amir

    2013-09-12

    In this paper, we propose an incremental multinode relaying protocol with arbitrary N-relay nodes that allows an efficient use of the channel spectrum. The destination combines the received signals from the source and the relays using maximal ratio Combining (MRC). The transmission ends successfully once the accumulated signal-to-noise ratio (SNR) exceeds a predefined threshold. The number of relays participating in the transmission is adapted to the channel conditions based on the feedback from the destination. The use of incremental relaying allows obtaining a higher spectral efficiency. Moreover, the symbol error probability (SEP) performance is enhanced by using MRC at the relays. The use of MRC at the relays implies that each relay overhears the signals from the source and all previous relays and combines them using MRC. The proposed protocol differs from most of existing relaying protocol by the fact that it combines both incremental relaying and MRC at the relays for a multinode topology. Our analyses for a decode-and-forward mode show that: (i) compared to existing multinode relaying schemes, the proposed scheme can essentially achieve the same SEP performance but with less average number of time slots, (ii) compared to schemes without MRC at the relays, the proposed scheme can approximately achieve a 3 dB gain.

  5. Commercialization and Standardization Progress Towards an Optical Communications Earth Relay

    Science.gov (United States)

    Edwards, Bernard L.; Israel, David J.

    2015-01-01

    NASA is planning to launch the next generation of a space based Earth relay in 2025 to join the current Space Network, consisting of Tracking and Data Relay Satellites in space and the corresponding infrastructure on Earth. While the requirements and architecture for that relay satellite are unknown at this time, NASA is investing in communications technologies that could be deployed to provide new communications services. One of those new technologies is optical communications. The Laser Communications Relay Demonstration (LCRD) project, scheduled for launch in 2018 as a hosted payload on a commercial communications satellite, is a critical pathfinder towards NASA providing optical communications services on the next generation space based relay. This paper will describe NASA efforts in the on-going commercialization of optical communications and the development of inter-operability standards. Both are seen as critical to making optical communications a reality on future NASA science and exploration missions. Commercialization is important because NASA would like to eventually be able to simply purchase an entire optical communications terminal from a commercial provider. Inter-operability standards are needed to ensure that optical communications terminals developed by one vendor are compatible with the terminals of another. International standards in optical communications would also allow the space missions of one nation to use the infrastructure of another.

  6. Efficient incremental relaying for packet transmission over fading channels

    KAUST Repository

    Fareed, Muhammad Mehboob

    2014-07-01

    In this paper, we propose a novel relaying scheme for packet transmission over fading channels, which improves the spectral efficiency of cooperative diversity systems by utilizing limited feedback from the destination. Our scheme capitalizes on the fact that relaying is only required when direct transmission suffers deep fading. We calculate the packet error rate for the proposed efficient incremental relaying (EIR) scheme with both amplify and forward and decode and forward relaying. We compare the performance of the EIR scheme with the threshold-based incremental relaying (TIR) scheme. It is shown that the efficiency of the TIR scheme is better for lower values of the threshold. However, the efficiency of the TIR scheme for higher values of threshold is outperformed by the EIR. In addition, three new threshold-based adaptive EIR are devised to further improve the efficiency of the EIR scheme. We calculate the packet error rate and the efficiency of these new schemes to provide the analytical insight. © 2014 IEEE.

  7. Implementing Strategic Planning Capabilities Within the Mars Relay Operations Service

    Science.gov (United States)

    Hy, Franklin; Gladden, Roy; Allard, Dan; Wallick, Michael

    2011-01-01

    Since the Mars Exploration Rovers (MER), Spirit and Opportunity, began their travels across the Martian surface in January of 2004, orbiting spacecraft such as the Mars 2001 Odyssey orbiter have relayed the majority of their collected scientific and operational data to and from Earth. From the beginning of those missions, it was evident that using orbiters to relay data to and from the surface of Mars was a vastly more efficient communications strategy in terms of power consumption and bandwidth compared to direct-to-Earth means. However, the coordination between the various spacecraft, which are largely managed independently and on differing commanding timelines, has always proven to be a challenge. Until recently, the ground operators of all these spacecraft have coordinated the movement of data through this network using a collection of ad hoc human interfaces and various, independent software tools. The Mars Relay Operations Service (MaROS) has been developed to manage the evolving needs of the Mars relay network, and specifically to standardize and integrate the relay planning and coordination data into a centralized infrastructure. This paper explores the journey of developing the MaROS system, from inception to delivery and acceptance by the Mars mission users.

  8. Relay-based information broadcast in complex networks

    Science.gov (United States)

    Fan, Zhongyan; Han, Zeyu; Tang, Wallace K. S.; Lin, Dong

    2018-04-01

    Information broadcast (IB) is a critical process in complex network, usually accomplished by flooding mechanism. Although flooding is simple and no prior topological information is required, it consumes a lot of transmission overhead. Another extreme is the tree-based broadcast (TB), for which information is disseminated via a spanning tree. It achieves the minimal transmission overhead but the maintenance of spanning tree for every node is an obvious obstacle for implementation. Motivated by the success of scale-free network models for real-world networks, in this paper, we investigate the issues in IB by considering an alternative solution in-between these two extremes. A novel relay-based broadcast (RB) mechanism is proposed by employing a subset of nodes as relays. Information is firstly forwarded to one of these relays and then re-disseminated to others through the spanning tree whose root is the relay. This mechanism provides a trade-off solution between flooding and TB. On one hand, it saves up a lot of transmission overhead as compared to flooding; on the other hand, it costs much less resource for maintenance than TB as only a few spanning trees are needed. Based on two major criteria, namely the transmission overhead and the convergence time, the effectiveness of RB is confirmed. The impacts of relay assignment and network structures on performance are also studied in this work.

  9. Systematic Network Coding with the Aid of a Full-Duplex Relay

    DEFF Research Database (Denmark)

    Giacaglia, Giuliano; Shi, Xiaomeng; Kim, MinJi

    2013-01-01

    is to deliver a given number of data packets to a receiver with the aid of a relay. The source broadcasts to both the receiver and the relay using one frequency, while the relay uses another frequency for transmissions to the receiver, allowing for a full-duplex operation of the relay. We analyze the decoding...... complexity and delay performance of two types of relays: one that preserves the systematic structure of the code from the source; another that does not. A systematic relay forwards uncoded packets upon reception, but transmits coded packets to the receiver after receiving the first coded packet from...

  10. Alternate MIMO AF relaying networks with interference alignment: Spectral efficient protocol and linear filter design

    KAUST Repository

    Park, Kihong

    2013-02-01

    In this paper, we study a two-hop relaying network consisting of one source, one destination, and three amplify-and-forward (AF) relays with multiple antennas. To compensate for the capacity prelog factor loss of 1/2$ due to the half-duplex relaying, alternate transmission is performed among three relays, and the inter-relay interference due to the alternate relaying is aligned to make additional degrees of freedom. In addition, suboptimal linear filter designs at the nodes are proposed to maximize the achievable sum rate for different fading scenarios when the destination utilizes a minimum mean-square error filter. © 1967-2012 IEEE.

  11. Theoretical Analysis of Proton Relays in Electrochemical Proton-Coupled Electron Transfer

    International Nuclear Information System (INIS)

    Auer, Benjamin; Fernandez, Laura; Hammes-Schiffer, Sharon

    2011-01-01

    The coupling of long-range electron transfer to proton transport over multiple sites plays a vital role in many biological and chemical processes. Recently a molecule with a hydrogen-bond relay inserted between the proton donor and acceptor sites in a proton-coupled electron transfer (PCET) system was studied electrochemically. The standard rate constants and kinetic isotope effects (KIEs) were measured experimentally for this system and a related single proton transfer system. In the present paper, these systems are studied theoretically using vibronically nonadiabatic rate constant expressions for electrochemical PCET. Application of this approach to proton relays requires the calculation of multidimensional proton vibrational wavefunctions and incorporation of multiple proton donor-acceptor motions. The calculated KIEs and relative standard rate constants for the single and double proton transfer systems are in agreement with the experimental data. The calculations indicate that the standard rate constant is lower for the double proton transfer system because of the smaller overlap integral between the ground state reduced and oxidized proton vibrational wavefunctions for this system, resulting in greater contributions from excited electron-proton vibronic states with higher free energy barriers. The decrease in proton donor-acceptor distances due to thermal fluctuations and the contributions from excited electron-proton vibronic states play important roles in proton relay systems. The theory suggests that the PCET rate constant may be increased by decreasing the equilibrium proton donor-acceptor distances or modifying the thermal motions of the molecule to facilitate the concurrent decrease of these distances. The submission of this journal article in ERIA is a requirement of the EFRC subcontract with Pennsylvania State University collaborators to get publications to OSTI.

  12. Effects of Single and Repeated Exposure to a 50-Hz 2-mT Electromagnetic Field on Primary Cultured Hippocampal Neurons.

    Science.gov (United States)

    Zeng, Ying; Shen, Yunyun; Hong, Ling; Chen, Yanfeng; Shi, Xiaofang; Zeng, Qunli; Yu, Peilin

    2017-06-01

    The prevalence of domestic and industrial electrical appliances has raised concerns about the health risk of extremely low-frequency magnetic fields (ELF-MFs). At present, the effects of ELF-MFs on the central nervous system are still highly controversial, and few studies have investigated its effects on cultured neurons. Here, we evaluated the biological effects of different patterns of ELF-MF exposure on primary cultured hippocampal neurons in terms of viability, apoptosis, genomic instability, and oxidative stress. The results showed that repeated exposure to 50-Hz 2-mT ELF-MF for 8 h per day after different times in culture decreased the viability and increased the production of intracellular reactive oxidative species in hippocampal neurons. The mechanism was potentially related to the up-regulation of Nox2 expression. Moreover, none of the repeated exposure patterns had significant effects on DNA damage, apoptosis, or autophagy, which suggested that ELF-MF exposure has no severe biological consequences in cultured hippocampal neurons.

  13. Motor Neurons

    DEFF Research Database (Denmark)

    Hounsgaard, Jorn

    2017-01-01

    Motor neurons translate synaptic input from widely distributed premotor networks into patterns of action potentials that orchestrate motor unit force and motor behavior. Intercalated between the CNS and muscles, motor neurons add to and adjust the final motor command. The identity and functional...... in in vitro preparations is far from complete. Nevertheless, a foundation has been provided for pursuing functional significance of intrinsic response properties in motoneurons in vivo during motor behavior at levels from molecules to systems....

  14. Latest Changes to NASA's Laser Communication Relay Demonstration Project

    Science.gov (United States)

    Edwards, Bernard L.; Israel, David J.; Vithlani, Seema K.

    2018-01-01

    Over the last couple of years, NASA has been making changes to the Laser Communications Relay Demonstration Project (LCRD), a joint project between NASA's Goddard Space Flight Center (GSFC), the Jet Propulsion Laboratory, California Institute of Technology (JPL), and the Massachusetts Institute of Technology Lincoln Laboratory (MIT/LL). The changes made makes LCRD more like a future Earth relay system that has both high speed optical and radio frequency links. This will allow LCRD to demonstrate a more detailed concept of operations for a future operational mission critical Earth relay. LCRD is expected to launch in June 2019 and is expected to be followed a couple of years later with a prototype user terminal on the International Space Station. LCRD's architecture will allow it to serve as a testbed in space and this paper will provide an update of its planned capabilities and experiments.

  15. Exact performance analysis of decode-and-forward opportunistic relaying

    KAUST Repository

    Tourki, Kamel

    2010-06-01

    In this paper, we investigate a dual-hop decode-and-forward opportunistic relaying scheme where the source may or may not be able to communicate directly with the destination. In our study, we consider a regenerative relaying scheme in which the decision to cooperate takes into account the effect of the possible erroneously detected and transmitted data at the best relay. We derive an exact closed-form expression for the end-to-end bit-error rate (BER) of binary phase-shift keying (BPSK) modulation based on the exact statistics of each hop. Unlike existing works where the analysis focused on high signal-to-noise ratio (SNR) regime, such results are important to enable the designers to take decisions regarding practical systems that operate at low SNR regime. We show that performance simulation results coincide with our analytical results.

  16. Telecommunications Relay Support of the Mars Phoenix Lander Mission

    Science.gov (United States)

    Edwards, Charles D., Jr.; Erickson, James K.; Gladden, Roy E.; Guinn, Joseph R.; Ilott, Peter A.; Jai, Benhan; Johnston, Martin D.; Kornfeld, Richard P.; Martin-Mur, Tomas J.; McSmith, Gaylon W.; hide

    2010-01-01

    The Phoenix Lander, first of NASA's Mars Scout missions, arrived at the Red Planet on May 25, 2008. From the moment the lander separated from its interplanetary cruise stage shortly before entry, the spacecraft could no longer communicate directly with Earth, and was instead entirely dependent on UHF relay communications via an international network of orbiting Mars spacecraft, including NASA's 2001 Mars Odyssey (ODY) and Mars Reconnaissance Orbiter (MRO) spacecraft, as well as ESA's Mars Express (MEX) spacecraft. All three orbiters captured critical event telemetry and/or tracking data during Phoenix Entry, Descent and Landing. During the Phoenix surface mission, ODY and MRO provided command and telemetry services, far surpassing the original data return requirements. The availability of MEX as a backup relay asset enhanced the robustness of the surface relay plan. In addition to telecommunications services, Doppler tracking observables acquired on the UHF link yielded an accurate position for the Phoenix landing site.

  17. Accurate performance analysis of opportunistic decode-and-forward relaying

    KAUST Repository

    Tourki, Kamel

    2011-07-01

    In this paper, we investigate an opportunistic relaying scheme where the selected relay assists the source-destination (direct) communication. In our study, we consider a regenerative opportunistic relaying scheme in which the direct path may be considered unusable, and the destination may use a selection combining technique. We first derive the exact statistics of each hop, in terms of probability density function (PDF). Then, the PDFs are used to determine accurate closed form expressions for end-to-end outage probability for a transmission rate R. Furthermore, we evaluate the asymptotical performance analysis and the diversity order is deduced. Finally, we validate our analysis by showing that performance simulation results coincide with our analytical results over different network architectures. © 2011 IEEE.

  18. Outage analysis for underlay relay-assisted cognitive networks

    KAUST Repository

    Tourki, Kamel; Qaraqe, Khalid A.; Alouini, Mohamed-Slim

    2012-01-01

    Cooperative relay technology was recently introduced into cognitive radio networks in order to enhance network capacity, scalability, and reliability of end-to-end communication. In this paper, we investigate an underlay cognitive network where the quality of service of the secondary link is maintained by triggering an opportunistic regenerative relaying once it falls under an unacceptable level. We first provide the exact cumulative density function (CDF) of received signal-to-noise (SNR) over each hop with co-located relays. Then, the CDFs are used to determine very accurate closed-form expression for the outage probability for a transmission rate R. We validate our analysis by showing that simulation results coincide with our analytical results in Rayleigh fading channels. © 2012 IEEE.

  19. Outage analysis for underlay relay-assisted cognitive networks

    KAUST Repository

    Tourki, Kamel

    2012-12-01

    Cooperative relay technology was recently introduced into cognitive radio networks in order to enhance network capacity, scalability, and reliability of end-to-end communication. In this paper, we investigate an underlay cognitive network where the quality of service of the secondary link is maintained by triggering an opportunistic regenerative relaying once it falls under an unacceptable level. We first provide the exact cumulative density function (CDF) of received signal-to-noise (SNR) over each hop with co-located relays. Then, the CDFs are used to determine very accurate closed-form expression for the outage probability for a transmission rate R. We validate our analysis by showing that simulation results coincide with our analytical results in Rayleigh fading channels. © 2012 IEEE.

  20. Cooperative AF Relaying in Spectrum-Sharing Systems: Outage Probability Analysis under Co-Channel Interferences and Relay Selection

    KAUST Repository

    Xia, Minghua

    2012-11-01

    For cooperative amplify-and-forward (AF) relaying in spectrum-sharing wireless systems, secondary users share spectrum resources originally licensed to primary users to communicate with each other and, thus, the transmit power of secondary transmitters is strictly limited by the tolerable interference powers at primary receivers. Furthermore, the received signals at a relay and at a secondary receiver are inevitably interfered by the signals from primary transmitters. These co-channel interferences (CCIs) from concurrent primary transmission can significantly degrade the performance of secondary transmission. This paper studies the effect of CCIs on outage probability of the secondary link in a spectrum-sharing environment. In particular, in order to compensate the performance loss due to CCIs, the transmit powers of a secondary transmitter and its relaying node are respectively optimized with respect to both the tolerable interference powers at the primary receivers and the CCIs from the primary transmitters. Moreover, when multiple relays are available, the technique of opportunistic relay selection is exploited to further improve system performance with low implementation complexity. By analyzing lower and upper bounds on the outage probability of the secondary system, this study reveals that it is the tolerable interference powers at primary receivers that dominate the system performance, rather than the CCIs from primary transmitters. System designers will benefit from this result in planning and designing next-generation broadband spectrum-sharing systems.