WorldWideScience

Sample records for significant mass losses

  1. Main sequence mass loss

    International Nuclear Information System (INIS)

    Brunish, W.M.; Guzik, J.A.; Willson, L.A.; Bowen, G.

    1987-01-01

    It has been hypothesized that variable stars may experience mass loss, driven, at least in part, by oscillations. The class of stars we are discussing here are the δ Scuti variables. These are variable stars with masses between about 1.2 and 2.25 M/sub θ/, lying on or very near the main sequence. According to this theory, high rotation rates enhance the rate of mass loss, so main sequence stars born in this mass range would have a range of mass loss rates, depending on their initial rotation velocity and the amplitude of the oscillations. The stars would evolve rapidly down the main sequence until (at about 1.25 M/sub θ/) a surface convection zone began to form. The presence of this convective region would slow the rotation, perhaps allowing magnetic braking to occur, and thus sharply reduce the mass loss rate. 7 refs

  2. Mass loss from S stars

    International Nuclear Information System (INIS)

    Jura, M.

    1988-01-01

    The mass-loss process in S stars is studied using 65 S stars from the listing of Wing and Yorka (1977). The role of pulsations in the mass-loss process is examined. It is detected that stars with larger mass-loss rates have a greater amplitude of pulsations. The dust-to-gas ratio for the S stars is estimated as 0.002 and the average mass-loss rate is about 6 x 10 to the -8th solar masses/yr. Some of the properties of the S stars, such as scale height, surface density, and lifetime, are measured. It is determined that scale height is 200 pc; the total duration of the S star phase is greater than or equal to 30,000 yr; and the stars inject 3 x 10 to the -6th solar masses/sq kpc yr into the interstellar medium. 46 references

  3. Mass loss and cepheid pulsation

    International Nuclear Information System (INIS)

    Davis, C.G. Jr.

    1977-01-01

    Two purposes are served: to discuss the latest improvements in nonlinear pulsation theory indicating the ability to resolve features such as the ''Christy bump'' on the light curves and to show from the results of a bump model and recent observations that mass loss is one of the possible explanations for the mass discrepancy problem between evolutionary and pulsation theories. Recent observations by Sanford and Gow of Los Alamos and Bernat (McDonald Observatory) show that extensive mass loss has occurred in the evolution of the M supergiant α Orionis

  4. Mass loss from Eta Carinae

    International Nuclear Information System (INIS)

    Andriesse, C.D.; Viotti, R.

    1979-01-01

    This high luminosity (5x10 6 solar luminosity) star since 1840 is losing mass at the rate of 7.5x10 -2 solar masses per year. The large mass loss could be the result of vibrational instabilities produced in the CNO hydrogen burning phase of a very massive (160 solar masses) star. The presence of high excitation lines in the ultraviolet spectrum of Eta Car suggests the idea of a hot zone excited by dissipation of the supersonic turbulent flow. (Auth.)

  5. Mass loss on the Asymptotic Giant Branch

    OpenAIRE

    Zijlstra, Albert

    2006-01-01

    Mass loss on the Asymptotic Giant Branch provides the origin of planetary nebulae. This paper reviews several relevant aspects of AGB evolution: pulsation properties, mass loss formalisms and time variable mass loss, evidence for asymmetries on the AGB, binarity, ISM interaction, and mass loss at low metallicity. There is growing evidence that mass loss on the AGB is already asymmetric, but with spherically symmetric velocity fields. The origin of the rings may be in pulsational instabilities...

  6. Mass-loss rates of cool stars

    Science.gov (United States)

    Katrien Els Decin, Leen

    2015-08-01

    Over much of the initial mass function, stars lose a significant fraction of their mass through a stellar wind during the late stages of their evolution when being a (super)giant star. As of today, we can not yet predict the mass-loss rate during the (super)giant phase for a given star with specific stellar parameters from first principles. This uncertainty directly impacts the accuracy of current stellar evolution and population synthesis models that predict the enrichment of the interstellar medium by these stellar winds. Efforts to establish the link between the initial physical and chemical conditions at stellar birth and the mass-loss rate during the (super)giant phase have proceeded on two separate tracks: (1) more detailed studies of the chemical and morpho-kinematical structure of the stellar winds of (super)giant stars in our own Milky Way by virtue of the proximity, and (2) large scale and statistical studies of a (large) sample of stars in other galaxies (such as the LMC and SMC) and globular clusters eliminating the uncertainty on the distance estimate and providing insight into the dependence of the mass-loss rate on the metallicity. In this review, I will present recent results of both tracks, will show how recent measurements confirm (some) theoretical predictions, but also how results from the first track admonish of common misconceptions inherent in the often more simplified analysis used to analyse the large samples from track 2.

  7. Mass loss from Wolf-Rayet stars

    International Nuclear Information System (INIS)

    Willis, A.J.

    1982-01-01

    Recent results relating to the stellar winds and mass loss rates of the WR stars are reviewed, emphasising new data and their interpretation acquired at UV, IR and Radio wavelengths. The subject is discussed under the headings: physical and chemical properties of WR stars (effective temperatures and radiative luminosities; masses; chemical abundances); velocity, ionisation and excitation structure of WR winds; mass loss rates of WR stars; mass loss properties of WR stars in the LMC; comparisons with theoretical models of mass loss; ring nebulae around WR stars; conclusions. (author)

  8. Evolutionary effects of mass loss in low-mass stars

    International Nuclear Information System (INIS)

    Renzini, A.

    1981-01-01

    The effects of mass loss on the evolution of low-mass stars (actual mass smaller than 1.4 solar masses) are reviewed. The case of globular cluster stars is discussed in some detail, and it is shown that evolutionary theory sets quite precise limits to the mass-loss rate in population II red giants. The effects of mass loss on the final evolutionary stages of stars producing white dwarfs is also discussed. In particular, the interaction of the wind from the hot central star with the surrounding planetary nebula is considered. Finally, the problem of the origin of hydrogen-deficient stars is briefly discussed. (Auth.)

  9. The Cepheid mass discrepancy and pulsation-driven mass loss

    NARCIS (Netherlands)

    Neilson, H.R.; Cantiello, M.; Langer, N.

    2011-01-01

    Context. A longstanding challenge for understanding classical Cepheids is the Cepheid mass discrepancy, where theoretical mass estimates using stellar evolution and stellar pulsation calculations have been found to differ by approximately 10−20%. Aims. We study the role of pulsation-driven mass loss

  10. Mass loss in early stages of stellar evolution

    International Nuclear Information System (INIS)

    Dearborn, D.S.P.; Kozlowski, M.; Schramm, D.

    1976-01-01

    It is known that stars lose mass between their birth on the main sequence and their death as white dwarfs, or as neutron stars or black holes for more massive stars. Solar wind considerations indicate that not all of the mass loss occurs in a 'last gasp' to form a planetary nebula. Mass loss has be observed in O-B stars and in red giants, but the mass loss observed in these stages do not appear sufficient to account for all the loss required for stars to become white dwarfs. The problem is at what stages and in what manner the excess mass is lost. Suggestions have tended to favour He flashes for stars with M < 2.25 M. and possibly double shell instability flashes for stars in the range from 2.25 M. to 8 M. Although is is possible that significant mass is lost during these stages, there appears to be no quantitative support for this suggestion, and in particular none for the He flash. It is shown here that there is increasing evidence for substantial mass loss during the immediate post main sequence stages when the star is moving from the main sequence to the giant branch. Mass loss at these early stages of evolution may have implications on the subsequent evolution of the star and the amount of nuclearly processed material that is ejected into the interstellar-medium. The behaviour of Arcturus is discussed in these connections. (U.K.)

  11. Increasing mass loss from Greenland's Mittivakkat Gletscher

    DEFF Research Database (Denmark)

    Hasholt, Bent; Mernild, S.H.; Knudsen, N.T.

    2011-01-01

    Warming in the Arctic during the past several decades has caused glaciers to thin and retreat, and recent mass loss from the Greenland Ice Sheet is well documented. Local glaciers peripheral to the ice sheet are also retreating, but few mass-balance observations are available to quantify that ret...... a local phenomenon, but are indicative of glacier changes in the broader region. Mass-balance observations for the MG therefore provide unique documentation of the general retreat of Southeast Greenland's local glaciers under ongoing climate warming....

  12. Mass Loss Rates of Fasting Polar Bears.

    Science.gov (United States)

    Pilfold, Nicholas W; Hedman, Daryll; Stirling, Ian; Derocher, Andrew E; Lunn, Nicholas J; Richardson, Evan

    2016-01-01

    Polar bears (Ursus maritimus) have adapted to an annual cyclic regime of feeding and fasting, which is extreme in seasonal sea ice regions of the Arctic. As a consequence of climate change, sea ice breakup has become earlier and the duration of the open-water period through which polar bears must rely on fat reserves has increased. To date, there is limited empirical data with which to evaluate the potential energetic capacity of polar bears to withstand longer fasts. We measured the incoming and outgoing mass of inactive polar bears (n = 142) that were temporarily detained by Manitoba Conservation and Water Stewardship during the open-water period near the town of Churchill, Manitoba, Canada, in 2009-2014. Polar bears were given access to water but not food and held for a median length of 17 d. Median mass loss rates were 1.0 kg/d, while median mass-specific loss rates were 0.5%/d, similar to other species with high adiposity and prolonged fasting capacities. Mass loss by unfed captive adult males was identical to that lost by free-ranging individuals, suggesting that terrestrial feeding contributes little to offset mass loss. The inferred metabolic rate was comparable to a basal mammalian rate, suggesting that while on land, polar bears can maintain a depressed metabolic rate to conserve energy. Finally, we estimated time to starvation for subadults and adult males for the on-land period. Results suggest that at 180 d of fasting, 56%-63% of subadults and 18%-24% of adult males in this study would die of starvation. Results corroborate previous assessments on the limits of polar bear capacity to withstand lengthening ice-free seasons and emphasize the greater sensitivity of subadults to changes in sea ice phenology.

  13. First stars. II. Evolution with mass loss

    Czech Academy of Sciences Publication Activity Database

    Bahena, David; Hadrava, Petr

    2012-01-01

    Roč. 337, č. 2 (2012), s. 651-663 ISSN 0004-640X R&D Projects: GA MŠk(CZ) LC506; GA ČR GA202/09/0772 Institutional research plan: CEZ:AV0Z10030501 Keywords : first stars * evolution * mass loss Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 2.064, year: 2012

  14. Pulsation, Mass Loss and the Upper Mass Limit

    Science.gov (United States)

    Klapp, J.; Corona-Galindo, M. G.

    1990-11-01

    RESUMEN. La existencia de estrellas con masas en exceso de 100 M0 ha sido cuestionada por mucho tiempo. Lfmites superiores para la masa de 100 M0 han sido obtenidos de teorfas de pulsaci6n y formaci6n estelar. En este trabajo nosotros primero investigamos la estabilidad radial de estrellas masivas utilizando la aproximaci6n clasica cuasiadiabatica de Ledoux, la aproximaci6n cuasiadiabatica de Castor y un calculo completamente no-adiabatico. Hemos encontrado que los tres metodos de calculo dan resultados similares siempre y cuando una pequefia regi6n de las capas externas de la estrella sea despreciada para la aproximaci6n clasica. La masa crftica para estabilidad de estrellas masivas ha sido encontrada en acuerdo a trabajos anteriores. Explicamos Ia discrepancia entre este y trabajos anteriores por uno de los autores. Discunmos calculos no-lineales y perdida de masa con respecto a) lfmite superior de masa. The existence of stars with masses in excess of 100 M0 has been questioned for a very long time. Upper mass limits of 100 Me have been obtained from pulsation and star formation theories. In this work we first investigate the radial stability of massive stars using the classical Ledoux's quasiadiabatic approximation. the Castor quasiadiabatic approximation and a fully nonadiabatic calculation. We have found that the three methods of calculation give similar results provided that a small region in outer layers of the star be neglected for the classical approximation. The critical mass for stability of massive stars is found to be in agreement with previous work. We explain the reason for the discrepancy between this and previous work by one of the authors. We discuss non-linear calculations and mass loss with regard to the upper mass limit. Key words: STARS-MASS FUNCTION - STARS-MASS LOSS - STARS-PULSATION

  15. 'Fat mass and obesity associated' gene (FTO: No significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents

    Directory of Open Access Journals (Sweden)

    Müller Timo D

    2008-09-01

    Full Text Available Abstract Background We have previously identified strong association of six single nucleotide polymorphisms (SNPs in FTO (fat mass and obesity associated gene to early onset extreme obesity within the first genome wide association study (GWA for this phenotype. The aim of this study was to investigate whether the obesity risk allele of one of these SNPs (rs9939609 is associated with weight loss in a lifestyle intervention program. Additionally, we tested for association of rs9939609 alleles with fasting blood parameters indicative of glucose and lipid metabolism. Methods We initially analysed rs9939609 in a case-control study comprising 519 German overweight and obese children and adolescents and 178 normal weight adults. In 207 of the obese individuals who took part in the outpatient obesity intervention program 'Obeldicks' we further analysed whether carrier status of the obesity risk A-allele of rs9939609 has a differential influence on weight loss after the intervention program. Additionally, we investigated in 480 of the overweight and obese patients whether rs9939609 is associated with fasting blood levels of glucose, triglycerides and HDL and LDL-cholesterol. Genotyping was performed using allele specific polymerase chain reaction (ARMS-PCR. For the association study (case-control approach, the Cochran-Armitage trend test was applied. Blood parameters were analysed using commercially available test kits and the log10-transformed blood parameters and changes in BMI-standard deviation scores (BMI-SDS were analysed by linear regression with sex and age as covariates under an additive mode of inheritance with the rs9939609 A-allele as risk allele. Results We confirmed the association of the risk A-allele of rs9939609 with overweight and early onset obesity (one sided p = 0.036. However, we observed no association of rs9939609 alleles with weight loss or fasting levels of blood glucose, triglycerides and cholesterol. Conclusion We confirmed

  16. Constraining the Stellar Mass Function in the Galactic Center via Mass Loss from Stellar Collisions

    Directory of Open Access Journals (Sweden)

    Douglas Rubin

    2011-01-01

    Full Text Available The dense concentration of stars and high-velocity dispersions in the Galactic center imply that stellar collisions frequently occur. Stellar collisions could therefore result in significant mass loss rates. We calculate the amount of stellar mass lost due to indirect and direct stellar collisions and find its dependence on the present-day mass function of stars. We find that the total mass loss rate in the Galactic center due to stellar collisions is sensitive to the present-day mass function adopted. We use the observed diffuse X-ray luminosity in the Galactic center to preclude any present-day mass functions that result in mass loss rates >10-5M⨀yr−1 in the vicinity of ~1″. For present-day mass functions of the form, dN/dM∝M-α, we constrain the present-day mass function to have a minimum stellar mass ≲7M⨀ and a power-law slope ≳1.25. We also use this result to constrain the initial mass function in the Galactic center by considering different star formation scenarios.

  17. Clouds enhance Greenland ice sheet mass loss

    Science.gov (United States)

    Van Tricht, Kristof; Gorodetskaya, Irina V.; L'Ecuyer, Tristan; Lenaerts, Jan T. M.; Lhermitte, Stef; Noel, Brice; Turner, David D.; van den Broeke, Michiel R.; van Lipzig, Nicole P. M.

    2015-04-01

    Clouds have a profound influence on both the Arctic and global climate, while they still represent one of the key uncertainties in climate models, limiting the fidelity of future climate projections. The potentially important role of thin liquid-containing clouds over Greenland in enhancing ice sheet melt has recently gained interest, yet current research is spatially and temporally limited, focusing on particular events, and their large scale impact on the surface mass balance remains unknown. We used a combination of satellite remote sensing (CloudSat - CALIPSO), ground-based observations and climate model (RACMO) data to show that liquid-containing clouds warm the Greenland ice sheet 94% of the time. High surface reflectivity (albedo) for shortwave radiation reduces the cloud shortwave cooling effect on the absorbed fluxes, while not influencing the absorption of longwave radiation. Cloud warming over the ice sheet therefore dominates year-round. Only when albedo values drop below ~0.6 in the coastal areas during summer, the cooling effect starts to overcome the warming effect. The year-round excess of energy due to the presence of liquid-containing clouds has an extensive influence on the mass balance of the ice sheet. Simulations using the SNOWPACK snow model showed not only a strong influence of these liquid-containing clouds on melt increase, but also on the increased sublimation mass loss. Simulations with the Community Earth System Climate Model for the end of the 21st century (2080-2099) show that Greenland clouds contain more liquid water path and less ice water path. This implies that cloud radiative forcing will be further enhanced in the future. Our results therefore urge the need for improving cloud microphysics in climate models, to improve future projections of ice sheet mass balance and global sea level rise.

  18. Mass loss from interacting close binary systems

    Science.gov (United States)

    Plavec, M. J.

    1981-01-01

    The three well-defined classes of evolved binary systems that show evidence of present and/or past mass loss are the cataclysmic variables, the Algols, and Wolf-Rayet stars. It is thought that the transformation of supergiant binary systems into the very short-period cataclysmic variables must have been a complex process. The new evidence that has recently been obtained from the far ultraviolet spectra that a certain subclass of the Algols (the Serpentids) are undergoing fairly rapid evolution is discussed. It is thought probable that the remarkable mass outflow observed in them is connected with a strong wind powered by accretion. The origin of the circumbinary clouds or flat disks that probably surround many strongly interacting binaries is not clear. Attention is also given to binary systems with hot white dwarf or subdwarf components, such as the symbiotic objects and the BQ stars; it is noted that in them both components may be prone to an enhanced stellar wind.

  19. The fluctuation theory of the stellar mass loss

    International Nuclear Information System (INIS)

    Andriesse, C.D.

    1981-01-01

    The idea that fluctuations in the mass flow are as significant as the very existence of the flow has led to the development of a fluctuation theory of the stellar mass loss. A general theory for fluctuations in non-equilibrium systems - and such are stellar atmospheres - was developed long ago. In developing the general theory to a specific stellar theory, however, the arguments have not come up in their logical order. The present sketch of this theory improves on that order and is offered as a framework for further study. (Auth.)

  20. Stringent limits on the ionized mass loss from A and F dwarfs

    International Nuclear Information System (INIS)

    Brown, A.; Veale, A.; Judge, P.; Bookbinder, J.A.; Hubeny, I.

    1990-01-01

    Following the suggestion of Willson et al. (1987) that A- and F-type main-sequence stars might undergo significant mass loss due to pulsationally driven winds, upper limits to the ionized mass loss from A and F dwarfs have been obtained using VLA observations. These stringent upper limits show that the level of ionized mass loss would have at most only a small effect on stellar evolution. Radiative-equilibrium atmospheric and wind models for early A dwarfs indicate that it is highly likely that a wind flowing from such stars would be significantly ionized. In addition, late A and early F dwarfs exhibit chromospheric emission indicative of significant nonradiative heating. The present mass-loss limits are thus representative of the total mass-loss rates for these stars. It is concluded that A and F dwarfs are not losing sufficient mass to cause A dwarfs to evolve into G dwarfs. 24 refs

  1. Greenland Ice Sheet Mass Loss from GRACE Monthly Models

    DEFF Research Database (Denmark)

    Sørensen, Louise Sandberg; Forsberg, René

    2010-01-01

    The Greenland ice sheet is currently experiencing a net mass loss. There are however large discrepancies between the published qualitative mass loss estimates, based on different data sets and methods. There are even large differences between the results based on the same data sources, as is the ...

  2. Significance of losses in water distribution systems in India

    OpenAIRE

    Raman, V.

    1983-01-01

    Effective management of water supply systems consists in supplying adequate quantities of clean water to the population. Detailed pilot studies of water distribution systems were carried out in 9 cities in India during 1971-81 to establish the feasibility of a programme of assessment, detection, and control of water losses from supply systems. A cost-benefit analysis was carried out. Water losses from mains and service pipes in the areas studied amounted to 20-35% of the total flow in the sys...

  3. Variation in body mass dynamics among sites in Black Brant Branta bernicla nigricans supports adaptivity of mass loss during moult

    Science.gov (United States)

    Fondell, Thomas F.; Flint, Paul L.; Schmutz, Joel A.; Schamber, Jason L.; Nicolai, Christopher A.

    2013-01-01

    Birds employ varying strategies to accommodate the energetic demands of moult, one important example being changes in body mass. To understand better their physiological and ecological significance, we tested three hypotheses concerning body mass dynamics during moult. We studied Black Brant in 2006 and 2007 moulting at three sites in Alaska which varied in food availability, breeding status and whether geese undertook a moult migration. First we predicted that if mass loss during moult were simply the result of inadequate food resources then mass loss would be highest where food was least available. Secondly, we predicted that if mass loss during moult were adaptive, allowing birds to reduce activity during moult, then birds would gain mass prior to moult where feeding conditions allowed and mass loss would be positively related to mass at moult initiation. Thirdly, we predicted that if mass loss during moult were adaptive, allowing birds to regain flight sooner, then across sites and groups, mass at the end of the flightless period would converge on a theoretical optimum, i.e. the mass that permits the earliest possible return to flight. Mass loss was greatest where food was most available and thus our results did not support the prediction that mass loss resulted from inadequate food availability. Mass at moult initiation was positively related to both food availability and mass loss. In addition, among sites and years, variation in mass was high at moult initiation but greatly reduced at the end of the flightless period, appearing to converge. Thus, our results supported multiple predictions that mass loss during moult was adaptive and that the optimal moulting strategy was to gain mass prior to the flightless period, then through behavioural modifications use these body reserves to reduce activity and in so doing also reduce wing loading. Geese that undertook a moult migration initiated moult at the highest mass, indicating that they were more than able to

  4. Significance of losses in water distribution systems in India.

    Science.gov (United States)

    Raman, V

    1983-01-01

    Effective management of water supply systems consists in supplying adequate quantities of clean water to the population. Detailed pilot studies of water distribution systems were carried out in 9 cities in India during 1971-81 to establish the feasibility of a programme of assessment, detection, and control of water losses from supply systems. A cost-benefit analysis was carried out. Water losses from mains and service pipes in the areas studied amounted to 20-35% of the total flow in the system. At a conservative estimate, the national loss of processed water through leaks in the water distribution systems amounts to 10(12) litres per year, which is equivalent to 500 million rupees.It is possible to bring down the water losses in the pipe mains to 3-5% of the total flow, and the cost incurred on the control programme can be recovered in 6-18 months. Appropriate conservation measures will help in achieving the goals of the International Water Supply and Sanitation Decade to provide clean water for all.

  5. Evolution of a 30 solar mass star: the interplay of nuclear burning and mass loss

    International Nuclear Information System (INIS)

    Falk, H.J.; Mitalas, R.

    1981-01-01

    Evolutionary tracks for a 30 solar mass star with various mass loss rates (MLR) were evolved to core He exhaustion. The 'overluminosity' of mass losing (ML) stars is explained in terms of the well known mass-luminosity (M-L) law. A critical ZAMS MLR above which mass loss leads to evolution to fainter luminosities is derived. Two tracks showed reversals in their direction of evolution across the HR diagram. These have been shown to be a consequence of mass loss dominating over the effects of the shell source. An analytic criterion for this condition has been derived. (Auth.)

  6. Constraining the Mass Loss Geometry of Beta Lyrae

    Directory of Open Access Journals (Sweden)

    Jamie R. Lomax

    2012-03-01

    Full Text Available Massive binary stars lose mass by two mechanisms: jet-driven mass loss during periods of active mass transfer and by wind-driven mass loss. Beta Lyrae is an eclipsing, semi-detached binary whose state of active mass transfer provides a unique opportunity to study how the evolution of binary systems is affected by jet-driven mass loss. Roche lobe overflow from the primary star feeds the thick accretion disk which almost completely obscures the mass-gaining star. A hot spot predicted to be on the edge of the accretion disk may be the source of beta Lyrae’s bipolar outflows. I present results from spectropolarimetric data taken with the University of Wisconsin’s Half-Wave Spectropolarimeter and the Flower and Cook Observatory’s photoelastic modulating polarimeter instrument which have implications for our current understanding of the system’s disk geometry. Using broadband polarimetric analysis, I derive new information about the structure of the disk and the presence and location of a hot spot. These results place constraints on the geometrical distribution of material in beta Lyrae and can help quantify the amount of mass lost from massive interacting binary systems during phases of mass transfer and jet-driven mass loss.

  7. Increased protein intake reduces lean body mass loss during weight loss in athletes.

    Science.gov (United States)

    Mettler, Samuel; Mitchell, Nigel; Tipton, Kevin D

    2010-02-01

    To examine the influence of dietary protein on lean body mass loss and performance during short-term hypoenergetic weight loss in athletes. In a parallel design, 20 young healthy resistance-trained athletes were examined for energy expenditure for 1 wk and fed a mixed diet (15% protein, 100% energy) in the second week followed by a hypoenergetic diet (60% of the habitual energy intake), containing either 15% (approximately 1.0 g x kg(-1)) protein (control group, n = 10; CP) or 35% (approximately 2.3 g x kg(-1)) protein (high-protein group, n = 10; HP) for 2 wk. Subjects continued their habitual training throughout the study. Total, lean body, and fat mass, performance (squat jump, maximal isometric leg extension, one-repetition maximum (1RM) bench press, muscle endurance bench press, and 30-s Wingate test) and fasting blood samples (glucose, nonesterified fatty acids (NEFA), glycerol, urea, cortisol, free testosterone, free Insulin-like growth factor-1 (IGF-1), and growth hormone), and psychologic measures were examined at the end of each of the 4 wk. Total (-3.0 +/- 0.4 and -1.5 +/- 0.3 kg for the CP and HP, respectively, P = 0.036) and lean body mass loss (-1.6 +/- 0.3 and -0.3 +/- 0.3 kg, P = 0.006) were significantly larger in the CP compared with those in the HP. Fat loss, performance, and most blood parameters were not influenced by the diet. Urea was higher in HP, and NEFA and urea showed a group x time interaction. Fatigue ratings and "worse than normal" scores on the Daily Analysis of Life Demands for Athletes were higher in HP. These results indicate that approximately 2.3 g x kg(-1) or approximately 35% protein was significantly superior to approximately 1.0 g x kg(-1) or approximately 15% energy protein for maintenance of lean body mass in young healthy athletes during short-term hypoenergetic weight loss.

  8. Surface mass balance contributions to acceleration of Antarctic ice mass loss during 2003-2013

    OpenAIRE

    Seo, Ki-Weon; Wilson, Clark R.; Scambos, Ted; Kim, Baek-Min; Waliser, Duane E.; Tian, Baijun; Kim, Byeong-Hoon; Eom, Jooyoung

    2015-01-01

    Abstract Recent observations from satellite gravimetry (the Gravity Recovery and Climate Experiment (GRACE) mission) suggest an acceleration of ice mass loss from the Antarctic Ice Sheet (AIS). The contribution of surface mass balance changes (due to variable precipitation) is compared with GRACE?derived mass loss acceleration by assessing the estimated contribution of snow mass from meteorological reanalysis data. We find that over much of the continent, the acceleration can be explained by ...

  9. Effects of main-sequence mass loss on stellar and galactic chemical evolution

    International Nuclear Information System (INIS)

    Guzik, J.A.

    1988-01-01

    L.A. Willson, G.H. Bowen and C. Struck-Marcell have proposed that 1 to 3 solar mass stars may experience evolutionarily significant mass loss during the early part of their main-sequence phase. The suggested mass-loss mechanism is pulsation, facilitated by rapid rotation. Initial mass-loss rates may be as large as several times 10 -9 M mass of sun/yr, diminishing over several times 10 8 years. The author attempts to test this hypothesis by comparing some theoretical implications with observations. Three areas are addressed: Solar models, cluster HR diagrams, and galactic chemical evolution. Mass-losing solar models were evolved that match the Sun's luminosity and radius at its present age. The most extreme viable models have initial mass 2.0 M 0 , and mass-loss rates decreasing exponentially over 2-3 x 10 8 years. Evolution calculations incorporating main-sequence mass loss were completed for a grid of models with initial masses 1.25 to 2.0 M mass of sun and mass loss timescales 0.2 to 2.0 Gry. Cluster HR diagrams synthesized with these models confirm the potential for the hypothesis to explain observed spreads or bifurcations in the upper main sequence, blue stragglers, anomalous giants, and poor fits of main-sequence turnoffs by standard isochrones. Simple closed galactic chemical evolution models were used to test the effects of main-sequence mass loss on the F and G dwarf distribution. Stars between 3.0 M mass of sun and a metallicity-dependent lower mass are assumed to lose mass. The models produce a 30 to 60% increase in the stars to stars-plus-remnants ratio, with fewer early-F dwarfs and many more late-F dwarfs remaining on the main sequence to the present

  10. MASS LOSS IN PRE-MAIN-SEQUENCE STARS VIA CORONAL MASS EJECTIONS AND IMPLICATIONS FOR ANGULAR MOMENTUM LOSS

    Energy Technology Data Exchange (ETDEWEB)

    Aarnio, Alicia N. [Astronomy Department, University of Michigan, 830 Dennison Building, 500 Church Street, Ann Arbor, MI 48109 (United States); Matt, Sean P. [Laboratoire AIM Paris-Saclay, CEA/Irfu Universite Paris-Diderot CNRS/INSU, F-91191 Gif-sur-Yvette (France); Stassun, Keivan G., E-mail: aarnio@umich.edu [Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 37235 (United States)

    2012-11-20

    We develop an empirical model to estimate mass-loss rates via coronal mass ejections (CMEs) for solar-type pre-main-sequence (PMS) stars. Our method estimates the CME mass-loss rate from the observed energies of PMS X-ray flares, using our empirically determined relationship between solar X-ray flare energy and CME mass: log (M {sub CME}[g]) = 0.63 Multiplication-Sign log (E {sub flare}[erg]) - 2.57. Using masses determined for the largest flaring magnetic structures observed on PMS stars, we suggest that this solar-calibrated relationship may hold over 10 orders of magnitude in flare energy and 7 orders of magnitude in CME mass. The total CME mass-loss rate we calculate for typical solar-type PMS stars is in the range 10{sup -12}-10{sup -9} M {sub Sun} yr{sup -1}. We then use these CME mass-loss rate estimates to infer the attendant angular momentum loss leading up to the main sequence. Assuming that the CME outflow rate for a typical {approx}1 M {sub Sun} T Tauri star is <10{sup -10} M {sub Sun} yr{sup -1}, the resulting spin-down torque is too small during the first {approx}1 Myr to counteract the stellar spin-up due to contraction and accretion. However, if the CME mass-loss rate is {approx}> 10{sup -10} M {sub Sun} yr{sup -1}, as permitted by our calculations, then the CME spin-down torque may influence the stellar spin evolution after an age of a few Myr.

  11. Mass loss rates of OB stars derived from infrared observations

    International Nuclear Information System (INIS)

    Tanzi, E.G.; Tarenghi, M.; Panagia, N.

    1981-01-01

    In this paper the authors report briefly on a study of the mass loss of early type stars in the infrared. Up to now near infrared (1.25 - 4.8 μ) broad band photometry of 70 southern OB stars of various luminosity class has been secured. Program stars have been selected, among those bright enough in the infrared to give a suitable photometric accuracy, in order to cover a wide range of spectral types. 37 stars are found to exhibit emission in excess over a blackbody photospheric continuum, which is interpreted in terms of gas ejected in the form of an accelerated wind. By means of model calculations the corresponding mass loss rates are derived. The obtained values compare well with those determined independently by various authors for stars in common. Their data show that mass loss rates increase with luminosity and are a decreasing function of surface gravity. (Auth.)

  12. A Mass Loss Penetration Model to Investigate the Dynamic Response of a Projectile Penetrating Concrete considering Mass Abrasion

    Directory of Open Access Journals (Sweden)

    NianSong Zhang

    2015-01-01

    Full Text Available A study on the dynamic response of a projectile penetrating concrete is conducted. The evolutional process of projectile mass loss and the effect of mass loss on penetration resistance are investigated using theoretical methods. A projectile penetration model considering projectile mass loss is established in three stages, namely, cratering phase, mass loss penetration phase, and remainder rigid projectile penetration phase.

  13. Massive stars with mass loss: Evolution, nucleosynthesis, and astrophysical implications

    International Nuclear Information System (INIS)

    Prantzos, N.

    1986-06-01

    Evolution and nucleosynthesis of mass loss WR stars is studied, particularly evolution of stars with initial mass between 50 and 100 solar masses, during combustion of H and He. A semi-empirical mass loss formalism, the Roxburgh criterion for convection, and nuclear data are used. Composition of the stellar surface and ejecta (and ejecta contribution to cosmic ray composition) are derived. The contribution of these stars to s elements in our solar system is shown. Their production of 26 Al is compared to the quantity in the galaxy. Gamma ray emission at 1.8 MeV from the decay of this radionuclide is estimated in galactic longitude. The stars evolve as 0 and 0f stars during H combustion and spend 20% of their He combustion period as WN stars and 80% as WC-W0. Evolution always occurs in the blue part of the HR diagram, and satisfies observational constraints on its upper part [fr

  14. Mass loss by stars on the asymptotic giant branch

    International Nuclear Information System (INIS)

    Frantsman, Yu.L.

    1986-01-01

    The theoretical populations of white dwarfs and carbon stars were generated for Salpeter initial mass function and constant stellar birth rate history. The effect of very strong mass loss on the mass distribution of white dwarfs and luminosity distribution of carbon stars is discussed and the results are compared with observations. This comparison suggested that a signioficant mass loss by stars on the asymptotic giant branch occurs besides stellar wind and planetary nebulae ejection. Thus it is possible to explain the absence of carbon stars with Msub(bol) 1.0 Msub(sun). The luminosity of asymptotic giant branch stars in the globular clusters of the Magellanic Clouds appears to be a very good indicator of the age

  15. The significance of postangiographic CT for differentiation of hepatic masses

    International Nuclear Information System (INIS)

    Lee, Jae Kyo; Chang, Jae Chun; Chang, You Song

    1994-01-01

    To identify the long term hemodynamics of various hepatic masses and to determine any differential findings by using postangiograpic CT performed with increased amount of contrast media and time than conventional contrast CT. 50 confirmed masses consisted of 22 hepatocellular carcinoma, 10 cholangiocarcinoma, 9 metastasis, and 9 cavernous hemangioma were included. The changes of the density of internal viable tumor portion relative to surrounding normal liver parenchyma in postangiograhic CT from that in conventional CT were classified as 3 patients; no specific changes, increase, or decrease. In 22 cases of hepatocellular carcinoma, six cases showed no relative density change, four cases increase, and twelve cases decrease. In ten cases of cholangiocacinoma, one case showed no change, nine cases increase. In nine cases of metastasis, four cases showed no change, five cases increase. In nine cases of hemangioma, all cases showed increase. In postangiographic CT which emphasize the significance of postequilibrium and delayed phase, other hemodynamic changes undetected in angiography could more easily be comprehended. Considering the differing amount of consumed contrast media and time duration, and with reference of other imaging modalities, differential diagnosis of hepatic masses based on long term hemodynamics could easily be made

  16. Counteracting age-related loss of skeletal muscle mass

    DEFF Research Database (Denmark)

    Bechshøft, Rasmus; Reitelseder, Søren; Højfeldt, Grith

    2016-01-01

    Background Aging is associated with decreased muscle mass and functional capacity, which in turn decrease quality of life. The number of citizens over the age of 65 years in the Western world will increase by 50 % over the next four decades, and this demographic shift brings forth new challenges...... at both societal and individual levels. Only a few longitudinal studies have been reported, but whey protein supplementation seems to improve muscle mass and function, and its combination with heavy strength training appears even more effective. However, heavy resistance training may reduce adherence...... Intervention Study will generate scientific evidence and recommendations to counteract age-related loss of skeletal muscle mass in elderly individuals....

  17. The coupling between pulsation and mass loss in massive stars

    OpenAIRE

    Townsend, Rich

    2007-01-01

    To what extent can pulsational instabilities resolve the mass-loss problem of massive stars? How important is pulsation in structuring and modulating the winds of these stars? What role does pulsation play in redistributing angular momentum in massive stars? Although I cannot offer answers to these questions, I hope at the very least to explain how they come to be asked.

  18. Effect of mass loss on the. beta. Cephei instability strip

    Energy Technology Data Exchange (ETDEWEB)

    Chiosi, C [Padua Univ. (Italy). Ist. di Astronomia

    1980-07-01

    In this paper we aim to suggest on a speculative basis that the existence of mass loss by stellar wind in massive stars (M > 10 Msub(sun)) may affect the properties of the ..beta.. Cephei instability strip, and remove some of the difficulties encountered in the interpretation of their pulsation.

  19. Inflammatory markers and loss of muscle mass (sarcopenia) and strength

    NARCIS (Netherlands)

    Schaap, Laura A; Pluijm, Saskia M F; Deeg, Dorly J H; Visser, Marjolein

    PURPOSE: The objective of this study was to investigate whether high levels of serum interleukin (IL)-6, C-reactive protein (CRP), and alpha1-antichymotrypsin (ACT) were associated with the loss of muscle strength or muscle mass (sarcopenia) in older persons. SUBJECTS: The study included 986 men and

  20. Mass loss rates in the Hertzsprung-Russell diagram

    International Nuclear Information System (INIS)

    Jager, C. de; Nieuwenhuijzen, H.; Hucht, K.A. van der

    1988-01-01

    From the literature we collected values for the rate of mass loss for 271 stars, nearly all of population I, and of spectral types 0 through M. Rates of stellar mass loss determined according to six different methods were compared and appear to yield the same result per star within the limits of errors; this is true regardless of the star's position in the HR-diagram. Thus average rates of mass loss were determined, and weights were allocated to the M-determinations for each star. In addition we studied some groups of other stars: fast rotators (22 Be-type stars), and chemically evolved stars (31 Wolf-Rayet stars; 11 C- and 4 S-type stars and 15 nuclei of planetary nebulae). The chemically evolved stars have rates of mass loss which are larger than those of ''normal'' stars occupying the same positions in the Hertzprung-Russel diagram, by factors: 160 for Wolf-Rayet stars; 11 for C-type stars, and by estimated factors of 10 3 to 10 4 for the nuclei of planetary nebulae

  1. Effects of mass loss on the evolution of massive stars. I. Main-sequence evolution

    International Nuclear Information System (INIS)

    Dearborn, D.S.P.; Blake, J.B.; Hainebach, K.L.; Schramm, D.N.

    1978-01-01

    The effect of mass loss on the evolution and surface composition of massive stars during main-sequence evolution are examined. While some details of the evolutionary track depend on the formula used for the mass loss, the results appear most sensitive to the total mass removed during the main-sequence lifetime. It was found that low mass-loss rates have very little effect on the evolution of a star; the track is slightly subluminous, but the lifetime is almost unaffected. High rates of mass loss lead to a hot, high-luminosity stellar model with a helium core surrounded by a hydrogen-deficient (Xapprox.0.1) envelope. The main-sequence lifetime is extended by a factor of 2--3. These models may be identified with Wolf-Rayet stars. Between these mass-loss extremes are intermediate models which appear as OBN stars on the main sequence. The mass-loss rates required for significant observable effects range from 8 x 10 -7 to 10 -5 M/sub sun/ yr -1 , depending on the initial stellar mass. It is found that observationally consistent mass-loss rates for stars with M> or =30 M/sub sun/ may be sufficiently high that these stars lose mass on a time scale more rapidly than their main-sequence core evolution time. This result implies that the helium cores resulting from the main-sequence evolution of these massive stars may all be very similar to that of a star of Mapprox.30 M/sub sun/ regardless of the zero-age mass

  2. THE EFFECT OF MASS LOSS ON THE TIDAL EVOLUTION OF EXTRASOLAR PLANET

    International Nuclear Information System (INIS)

    Guo, J. H.

    2010-01-01

    By combining mass loss and tidal evolution of close-in planets, we present a qualitative study on their tidal migrations. We incorporate mass loss in tidal evolution for planets with different masses and find that mass loss could interfere with tidal evolution. In an upper limit case (β = 3), a significant portion of mass may be evaporated in a long evolution timescale. Evidence of greater modification of the planets with an initial separation of about 0.1 AU than those with a = 0.15 AU can be found in this model. With the assumption of a large initial eccentricity, the planets with initial mass ≤1 M J and initial distance of about 0.1 AU could not survive. With the supposition of β = 1.1, we find that the loss process has an effect on the planets with low mass at a ∼ 0.05 AU. In both cases, the effect of evaporation on massive planets can be neglected. Also, heating efficiency and initial eccentricity have significant influence on tidal evolution. We find that even low heating efficiency and initial eccentricity have a significant effect on tidal evolution. Our analysis shows that evaporation on planets with different initial masses can accelerate (decelerate) the tidal evolution due to the increase (decrease) in tide of the planet (star). Consequently, the effect of evaporation cannot be neglected in evolutionary calculations of close-in planets. The physical parameters of HD 209458b can be fitted by our model.

  3. Significancy in atomic mass measurements and the topography of the mass-surface

    International Nuclear Information System (INIS)

    Audi, G.

    1991-01-01

    It is discussed how to explore new regions of the chart of the nuclides through masses, and what has to be understood under significant mass measurements. In the exploratory phase of a new region of the chart, a result with almost any accuracy is appropriate. The higher the accuracy is, the better the possibility is to see finer structures. (G.P.) 24 refs.; 10 figs

  4. Chlorine loss and mass loss from polyvinylchloride and polyvinylidenchloride under the electron beam

    International Nuclear Information System (INIS)

    Lindberg, K.A.H.; Bertilsson, H.E.

    1985-01-01

    The loss of chlorine during the irradiation of PVC and PVDC in the electron microscope has been measured by the decay of the X-ray chlorine Kα signal. A number of factors affecting the measured beam damage curves have been considered and the experimental errors reduced to +- 10%. The results show that the chlorine decay curves can be best described by the sum of two exponentials, corresponding to the two different chlorine decay processes, these being: the dehydrochlorination of the polymer molecules and the dehydrochlorination of the polyene structure formed by the beam damage. The higher initial chlorine content of PVDC compared to PVC will result in a larger amount of chlorine atoms reacting with the polyene structure, which is more stable in the electron beam than the undamaged polymer. The chlorine loss, measured by X-ray analysis, has been compared to the mass loss, measured by energy loss analysis, and also with the volume changes of isolated spherical PVC particles. It has been concluded that the mass loss is almost entirely due to chlorine loss and that the residual structure has a density similar to the undamaged PVC. (author)

  5. Irreversible mass loss of Canadian Arctic Archipelago glaciers

    NARCIS (Netherlands)

    Lenaerts, J.T.M.|info:eu-repo/dai/nl/314850163; van Angelen, J.H.|info:eu-repo/dai/nl/325922470; van den Broeke, M.R.|info:eu-repo/dai/nl/073765643; Gardner, A.S.; Wouters, Bert|info:eu-repo/dai/nl/304120146; van Meijgaard, E.

    2013-01-01

    The Canadian Arctic Archipelago (CAA) contains the largest volume of glacier ice on Earth outside of Antarctica and Greenland. In the absence of significant calving, CAA glacier mass balance is governed by the difference between surface snow accumulation and meltwater runoff—surface mass balance.

  6. CONNECTING FLARES AND TRANSIENT MASS-LOSS EVENTS IN MAGNETICALLY ACTIVE STARS

    Energy Technology Data Exchange (ETDEWEB)

    Osten, Rachel A. [Space Telescope Science Institute 3700 San Martin Drive, Baltimore, MD 21218 (United States); Wolk, Scott J., E-mail: osten@stsci.edu [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge MA 02138 (United States)

    2015-08-10

    We explore the ramification of associating the energetics of extreme magnetic reconnection events with transient mass-loss in a stellar analogy with solar eruptive events. We establish energy partitions relative to the total bolometric radiated flare energy for different observed components of stellar flares and show that there is rough agreement for these values with solar flares. We apply an equipartition between the bolometric radiated flare energy and kinetic energy in an accompanying mass ejection, seen in solar eruptive events and expected from reconnection. This allows an integrated flare rate in a particular waveband to be used to estimate the amount of associated transient mass-loss. This approach is supported by a good correspondence between observational flare signatures on high flaring rate stars and the Sun, which suggests a common physical origin. If the frequent and extreme flares that young solar-like stars and low-mass stars experience are accompanied by transient mass-loss in the form of coronal mass ejections, then the cumulative effect of this mass-loss could be large. We find that for young solar-like stars and active M dwarfs, the total mass lost due to transient magnetic eruptions could have significant impacts on disk evolution, and thus planet formation, and also exoplanet habitability.

  7. Plant litter functional diversity effects on litter mass loss depend on the macro-detritivore community.

    Science.gov (United States)

    Patoine, Guillaume; Thakur, Madhav P; Friese, Julia; Nock, Charles; Hönig, Lydia; Haase, Josephine; Scherer-Lorenzen, Michael; Eisenhauer, Nico

    2017-11-01

    A better understanding of the mechanisms driving litter diversity effects on decomposition is needed to predict how biodiversity losses affect this crucial ecosystem process. In a microcosm study, we investigated the effects of litter functional diversity and two major groups of soil macro-detritivores on the mass loss of tree leaf litter mixtures. Furthermore, we tested the effects of litter trait community means and dissimilarity on litter mass loss for seven traits relevant to decomposition. We expected macro-detritivore effects on litter mass loss to be most pronounced in litter mixtures of high functional diversity. We used 24 leaf mixtures differing in functional diversity, which were composed of litter from four species from a pool of 16 common European tree species. Earthworms, isopods, or a combination of both were added to each litter combination for two months. Litter mass loss was significantly higher in the presence of earthworms than in that of isopods, whereas no synergistic effects of macro-detritivore mixtures were found. The effect of functional diversity of the litter material was highest in the presence of both macro-detritivore groups, supporting the notion that litter diversity effects are most pronounced in the presence of different detritivore species. Species-specific litter mass loss was explained by nutrient content, secondary compound concentration, and structural components. Moreover, dissimilarity in N concentrations increased litter mass loss, probably because detritivores having access to nutritionally diverse food sources. Furthermore, strong competition between the two macro-detritivores for soil surface litter resulted in a decrease of survival of both macro-detritivores. These results show that the effects of litter functional diversity on decomposition are contingent upon the macro-detritivore community and composition. We conclude that the temporal dynamics of litter trait diversity effects and their interaction with

  8. Effects of Main-Sequence Mass Loss on Stellar and Galactic Chemical Evolution.

    Science.gov (United States)

    Guzik, Joyce Ann

    1988-06-01

    L. A. Willson, G. H. Bowen and C. Struck -Marcell have proposed that 1 to 3 solar mass stars may experience evolutionarily significant mass loss during the early part of their main-sequence phase. The suggested mass-loss mechanism is pulsation, facilitated by rapid rotation. Initial mass-loss rates may be as large as several times 10^{-9}M o/yr, diminishing over several times 10^8 years. We attempted to test this hypothesis by comparing some theoretical implications with observations. Three areas are addressed: Solar models, cluster HR diagrams, and galactic chemical evolution. Mass-losing solar models were evolved that match the Sun's luminosity and radius at its present age. The most extreme viable models have initial mass 2.0 M o, and mass-loss rates decreasing exponentially over 2-3 times 10^8 years. Compared to a constant -mass model, these models require a reduced initial ^4He abundance, have deeper envelope convection zones and higher ^8B neutrino fluxes. Early processing of present surface layers at higher interior temperatures increases the surface ^3He abundance, destroys Li, Be and B, and decreases the surface C/N ratio following first dredge-up. Evolution calculations incorporating main-sequence mass loss were completed for a grid of models with initial masses 1.25 to 2.0 Mo and mass loss timescales 0.2 to 2.0 Gyr. Cluster HR diagrams synthesized with these models confirm the potential for the hypothesis to explain observed spreads or bifurcations in the upper main sequence, blue stragglers, anomalous giants, and poor fits of main-sequence turnoffs by standard isochrones. Simple closed galactic chemical evolution models were used to test the effects of main-sequence mass loss on the F and G dwarf distribution. Stars between 3.0 M o and a metallicity -dependent lower mass are assumed to lose mass. The models produce a 30 to 60% increase in the stars to stars-plus -remnants ratio, with fewer early-F dwarfs and many more late-F dwarfs remaining on the main

  9. Low-mass stars with mass loss and low-luminosity carbon star formation

    International Nuclear Information System (INIS)

    Boothroyd, A.I.

    1987-01-01

    The effects of large carbon enrichments in static stellar envelopes were investigated, using new Los Alamos opacities (including low-temperature carbon and molecular opacities) and including carbon ionizations. To search for the production of low-mass,low-luminosity carbon stars, detailed stellar evolutionary computations were carried out for a grid of low-mass stars of two different metallicities. The stars were evolved from the main sequence through all intermediate stages and through helium-shell flashes on the asymptotic giant branch. The effects of the latest nuclear reaction rates, the new Los Alamos opacities, Reimers-type wind mass loss, and detailed treatment of convection and semi-convection were investigated. Two low-luminosity carbon stars were achieved, in excellent agreement with observations. Conditions favoring dredge-up (and thus carbon-star production) include a reasonably large convective mixing length, low metallicity, relatively large envelope mass, and high flash strength. Mass loss was of major importance, tending to oppose dredge-up; the total mass-loss amounts inferred from observations suffice to prevent formation of high-mass, high-luminosity carbon stars

  10. Prevalence of skeletal muscle mass loss and its association with swallowing function after cardiovascular surgery.

    Science.gov (United States)

    Wakabayashi, Hidetaka; Takahashi, Rimiko; Watanabe, Naoko; Oritsu, Hideyuki; Shimizu, Yoshitaka

    2017-06-01

    The aim of this study was to assess the prevalence of skeletal muscle mass loss and its association with swallowing function in patients with dysphagia after cardiovascular surgery. A retrospective cohort study was performed in 65 consecutive patients with dysphagia after cardiovascular surgery who were prescribed speech therapy. Skeletal muscle index (SMI) was calculated as total psoas muscle area assessed via abdominal computed tomography divided by height squared. Cutoff values were 6.36 cm 2 /m 2 for men and 3.92 cm 2 /m 2 for women. The Food Intake Level Scale (FILS) was used to assess the swallowing function. Univariate and ordered logistic regression analyses were applied to examine the associations between skeletal muscle mass loss and dysphagia. The study included 50 men and 15 women (mean age 73 ± 8 y). The mean SMI was 4.72 ± 1.37 cm 2 /m 2 in men and 3.33 ± 1.42 cm 2 /m 2 in women. Skeletal muscle mass loss was found in 53 (82%) patients. Twelve had tracheostomy cannula. Thirteen were non-oral feeding (FILS levels 1-3), 5 were oral food intake and alternative nutrition (levels 4-6), and 47 were oral food intake alone (levels 7-9) at discharge. The FILS at discharge was significantly lower in patients with skeletal muscle mass loss. Ordered logistic regression analysis of swallowing function showed that skeletal muscle mass loss and tracheostomy cannula were associated independently with the FILS at discharge. The prevalence of skeletal muscle mass loss is very high, and skeletal muscle mass loss is associated with swallowing function. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Convection and mass loss through the chromosphere of Betelgeuse

    Science.gov (United States)

    Ridgway, Stephen

    2011-10-01

    Betelgeuse is well suited for detailed study of the mass loss process in a massive red supergiant. We have engaged in a multi-scale, multi-color study to trace the ejected material from the photosphere to the interstellar medium, and understand its chemical evolution {formation of molecules and dust}. Infrared interferometry already gave us a detailed image of the photosphere, compatible with large convective cells. Adaptive optics spectro-imaging {1.0-2.2 microns} allowed us to detect the presence of the CN molecule and mass loss plume structures up to at least 6 R*. At larger distances, we observed silicate-rich dust in thermal IR {8-20 microns}. From the surface to 100 R*, we therefore have a continuous coverage with multicolor imagery. The chromosphere lies at a key location, between the photosphere and the molecular envelope. As shown by STIS spatially resolved spectroscopy {Lobel & Dupree 2001}, it contains rising and falling gases. Such structure is supported by our 3D modeling of the convection. In order to probe the dynamics of the envelope and its relation to photospheric spots and mass loss plumes, we propose to obtain UV imaging with STIS at 3 epochs to complement our coordinated ground-based effort as well as the earlier HST UV snapshots. We will use this imagery to correlate structures at different radii and temperatures, and to explore the time-scales of evolution. With the support of our 3D models, this information will answer specific questions including deciding between convective and polar explanations for bright spots and plumes. Our infrared imaging observations will be repeated contemporaneously with the requested HST/STIS images.

  12. Delta progradation in Greenland driven by increasing glacial mass loss

    DEFF Research Database (Denmark)

    Bendixen, Mette; Iversen, Lars Lonsmann; Bjork, Anders Anker

    2017-01-01

    imagery. We find that delta progradation was driven by high freshwater runoff from the Greenland Ice Sheet coinciding with periods of open water. Progradation was controlled by the local initial environmental conditions (that is, accumulated air temperatures above 0 degrees C per year, freshwater runoff...... of erosion and accretion along the large deltas of the main rivers in the Arctic5-7. Our results improve the understanding of Arctic coastal evolution in a changing climate, and reveal the impacts on coastal areas of increasing ice mass loss and the associated freshwater runoff and lengthening of open-water...

  13. Mass loss from the K dwarf in V471 Tauri

    International Nuclear Information System (INIS)

    Mullan, D.J.; Bruhweiler, F.; Sion, E.M.

    1988-01-01

    Spectra of MgII h and k have been obtained for V471 Tau at phases zero (K dwarf in front) and 0.5 (white dwarf in front). At phase zero, strong blueshifted absorption is present, suggestive of a wind from the K dwarf with terminal velocity 600-700 km/sec and mass loss rate at least three orders of magnitude greater than solar. Discrete blue-shifted absorption features occur at velocities of about 200 and 500 km/sec. At phase 0.5, the blueshifted absorption is much weaker, although still detectable

  14. Evidence for Pulsation-Driven Mass Loss from δ Cephei

    Science.gov (United States)

    Marengo, M.; Evans, N. R.; Matthews, L. D.; Bono, G.; Barmby, P.; Welch, D. L.; Romaniello, M.; Su, K. Y. L.; Fazio, G. G.; Huelsman, D.

    We found the first direct evidence that the Cepheid class namesake, δ Cephei, is currently losing mass. These observations are based on data obtained with the Spitzer Space Telescope in the infrared, and with the Very Large Array in the radio. We found that δ Cephei is associated with a vast circumstellar structure, reminiscent of a bow shock. This structure is created as the wind from the star interacts with the local interstellar medium. We measure an outflow velocity of ≈ 35. 5 km s- 1 and a mass loss rate of ≈ 10- 7-10- 6 M ⊙ year- 1. The very low dust content of the outflow suggests that the wind is possibly pulsation-driven, rather than dust-driven as common for other classes of evolved stars.

  15. Surface Mass Balance Contributions to Acceleration of Antarctic Ice Mass Loss during 2003- 2013

    Science.gov (United States)

    Seo, K. W.; Wilson, C. R.; Scambos, T. A.; Kim, B. M.; Waliser, D. E.; Tian, B.; Kim, B.; Eom, J.

    2015-12-01

    Recent observations from satellite gravimetry (the GRACE mission) suggest an acceleration of ice mass loss from the Antarctic Ice Sheet (AIS). The contribution of surface mass balance changes (due to variable precipitation) is compared with GRACE-derived mass loss acceleration by assessing the estimated contribution of snow mass from meteorological reanalysis data. We find that over much of the continent, the acceleration can be explained by precipitation anomalies. However, on the Antarctic Peninsula and other parts of West Antarctica mass changes are not explained by precipitation and are likely associated with ice discharge rate increases. The total apparent GRACE acceleration over all of the AIS between 2003 and 2013 is -13.6±7.2 GTon/yr2. Of this total, we find that the surface mass balance component is -8.2±2.0 GTon/yr2. However, the GRACE estimate appears to contain errors arising from the atmospheric pressure fields used to remove air mass effects. The estimated acceleration error from this effect is about 9.8±5.8 GTon/yr2. Correcting for this yields an ice discharge acceleration of -15.1±6.5 GTon/yr2.

  16. Increase in transmission loss of single panels by addition of mass inclusions to a poro-elastic layer: Experimental investigation

    Science.gov (United States)

    Kidner, M. R. F.; Fuller, C. R.; Gardner, B.

    2006-06-01

    The insertion loss of standard acoustic blankets can be significantly improved at low frequencies by the addition of randomly placed mass inclusions to the poro-elastic layers. The improvement is much greater than that due to the mass effect alone. The mass inclusions act as resonant systems and so increase the structure impedance. This paper reports the results of experimental investigations into this phenomenon. Increases in insertion loss of 15 dB in the 100 Hz third octave band are reported.

  17. Asymptotically simple spacetimes and mass loss due to gravitational waves

    Science.gov (United States)

    Saw, Vee-Liem

    The cosmological constant Λ used to be a freedom in Einstein’s theory of general relativity (GR), where one had a proclivity to set it to zero purely for convenience. The signs of Λ or Λ being zero would describe universes with different properties. For instance, the conformal structure of spacetime directly depends on Λ: null infinity ℐ is a spacelike, null, or timelike hypersurface, if Λ > 0, Λ = 0, or Λ 0 in Einstein’s theory of GR. A quantity that depends on the conformal structure of spacetime, especially on the nature of ℐ, is the Bondi mass which in turn dictates the mass loss of an isolated gravitating system due to energy carried away by gravitational waves. This problem of extending the Bondi mass to a universe with Λ > 0 has spawned intense research activity over the past several years. Some aspects include a closer inspection on the conformal properties, working with linearization, attempts using a Hamiltonian formulation based on “linearized” asymptotic symmetries, as well as obtaining the general asymptotic solutions of de Sitter-like spacetimes. We consolidate on the progress thus far from the various approaches that have been undertaken, as well as discuss the current open problems and possible directions in this area.

  18. Core-powered mass-loss and the radius distribution of small exoplanets

    Science.gov (United States)

    Ginzburg, Sivan; Schlichting, Hilke E.; Sari, Re'em

    2018-05-01

    Recent observations identify a valley in the radius distribution of small exoplanets, with planets in the range 1.5-2.0 R⊕ significantly less common than somewhat smaller or larger planets. This valley may suggest a bimodal population of rocky planets that are either engulfed by massive gas envelopes that significantly enlarge their radius, or do not have detectable atmospheres at all. One explanation of such a bimodal distribution is atmospheric erosion by high-energy stellar photons. We investigate an alternative mechanism: the luminosity of the cooling rocky core, which can completely erode light envelopes while preserving heavy ones, produces a deficit of intermediate sized planets. We evolve planetary populations that are derived from observations using a simple analytical prescription, accounting self-consistently for envelope accretion, cooling and mass-loss, and demonstrate that core-powered mass-loss naturally reproduces the observed radius distribution, regardless of the high-energy incident flux. Observations of planets around different stellar types may distinguish between photoevaporation, which is powered by the high-energy tail of the stellar radiation, and core-powered mass-loss, which depends on the bolometric flux through the planet's equilibrium temperature that sets both its cooling and mass-loss rates.

  19. Acceleration of the GrIS mass loss as observed by GRACE

    DEFF Research Database (Denmark)

    Svendsen, Peter Limkilde; Andersen, Ole Baltazar; Nielsen, Allan Aasbjerg

    2012-01-01

    The mass loss of the Greenland Ice Sheet (GrIS) has previously been analysed in a variety of ways, including altimetry, gravimetry and mass budget calculations, establishing a continuing decrease in the ice mass, with a number of studies finding acceleration in the mass loss. Here, we examine...

  20. Exploring energy loss by vector flow mapping in children with ventricular septal defect: Pathophysiologic significance.

    Science.gov (United States)

    Honda, Takashi; Itatani, Keiichi; Takanashi, Manabu; Kitagawa, Atsushi; Ando, Hisashi; Kimura, Sumito; Oka, Norihiko; Miyaji, Kagami; Ishii, Masahiro

    2017-10-01

    Vector flow mapping is a novel echocardiographic flow visualization method, and it has enabled us to quantitatively evaluate the energy loss in the left ventricle (intraventricular energy loss). Although intraventricular energy loss is assumed to be a part of left ventricular workload itself, it is unclear what this parameter actually represents. The aim of the present study was to elucidate the characteristics of intraventricular energy loss. We enrolled 26 consecutive children with ventricular septal defect (VSD). On echocardiography vector flow mapping, intraventricular energy loss was measured in the apical 3-chamber view. We measured peak energy loss and averaged energy loss in the diastolic and systolic phases, and subsequently compared these parameters with catheterization parameters and serum brain natrium peptide (BNP) level. Diastolic, peak, and systolic energy loss were strongly and positively correlated with right ventricular systolic pressure (r=0.76, 0.68, and 0.56, p<0.0001, = 0.0001, and 0.0029, respectively) and right ventricular end diastolic pressure (r=0.55, 0.49, and 0.49, p=0.0038, 0.0120, and 0.0111, respectively). In addition, diastolic, peak, and systolic energy loss were significantly correlated with BNP (r=0.75, 0.69 and 0.49, p<0.0001, < 0.0001, and=0.0116, respectively). In children with VSD, elevated right ventricular pressure is one of the factors that increase energy loss in the left ventricle. The results of the present study encourage further studies in other study populations to elucidate the characteristics of intraventricular energy loss for its possible clinical application. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. DUST PRODUCTION AND MASS LOSS IN THE GALACTIC GLOBULAR CLUSTER 47 TUCANAE

    International Nuclear Information System (INIS)

    McDonald, I.; Zijlstra, A. A.; Boyer, M. L.; Van Loon, J. Th.

    2011-01-01

    Dust production among post-main-sequence stars is investigated in the Galactic globular cluster 47 Tucanae (NGC 104) based on infrared photometry and spectroscopy. We identify metallic iron grains as the probable dominant opacity source in these winds. Typical evolutionary timescales of asymptotic giant branch stars suggest the mass-loss rates we report are too high. We suggest that this is because the iron grains are small or elongated and/or that iron condenses more efficiently than at solar metallicity. Comparison to other works suggests metallic iron is observed to be more prevalent toward lower metallicities. The reasons for this are explored, but remain unclear. Meanwhile, the luminosity at which dusty mass loss begins is largely invariant with metallicity, but its presence correlates strongly with long-period variability. This suggests that the winds of low-mass stars have a significant driver that is not radiation pressure, but may be acoustic driving by pulsations.

  2. Accelerated ice-sheet mass loss in Antarctica from 18-year satellite laser ranging measurements

    Directory of Open Access Journals (Sweden)

    Shuanggen Jin

    2016-02-01

    Full Text Available Accurate estimate of the ice-sheet mass balance in Antarctic is very difficult due to complex ice sheet condition and sparse in situ measurements. In this paper, the low-degree gravity field coefficients of up to degree and order 5 derived from Satellite Laser Ranging (SLR measurements are used to determine the ice mass variations in Antarctica for the period 1993–2011. Results show that the ice mass is losing with -36±13 Gt/y in Antarctica, -42±11 Gt/y in the West Antarctica and 6±10 Gt/y in the East Antarctica from 1993 to 2011. The ice mass variations from the SLR 5×5 have a good agreement with the GRACE 5×5, GRACE 5×5 (1&2 and GRACE (60×60 for the entire continent since 2003, but degree 5 from SLR is not sufficient to quantify ice losses in West and East Antarctica, respectively. The rate of ice loss in Antarctica is -28±17 Gt/y for 1993-2002 and -55±17 Gt/y for 2003-2011, indicating significant accelerated ice mass losses since 2003. Furthermore, the results from SLR are comparable with GRACE measurements.

  3. Probing the mass-loss history of AGB and red supergiant stars from CO rotational line profiles - I. Theoretical model - Mass-loss history unravelled in VYCMa

    NARCIS (Netherlands)

    Decin, L.; Hony, S.; de Koter, A.; Justtanont, K.; Tielens, A. G. G. M.; Waters, L. B. F. M.

    Context. Mass loss plays a dominant role in the evolution of low mass stars while they are on the Asymptotic Giant Branch (AGB). The gas and dust ejected during this phase are a major source in the mass budget of the interstellar medium. Recent studies have pointed towards the importance of

  4. Global-scale hydrological response to future glacier mass loss

    Science.gov (United States)

    Huss, Matthias; Hock, Regine

    2018-01-01

    Worldwide glacier retreat and associated future runoff changes raise major concerns over the sustainability of global water resources1-4, but global-scale assessments of glacier decline and the resulting hydrological consequences are scarce5,6. Here we compute global glacier runoff changes for 56 large-scale glacierized drainage basins to 2100 and analyse the glacial impact on streamflow. In roughly half of the investigated basins, the modelled annual glacier runoff continues to rise until a maximum (`peak water') is reached, beyond which runoff steadily declines. In the remaining basins, this tipping point has already been passed. Peak water occurs later in basins with larger glaciers and higher ice-cover fractions. Typically, future glacier runoff increases in early summer but decreases in late summer. Although most of the 56 basins have less than 2% ice coverage, by 2100 one-third of them might experience runoff decreases greater than 10% due to glacier mass loss in at least one month of the melt season, with the largest reductions in central Asia and the Andes. We conclude that, even in large-scale basins with minimal ice-cover fraction, the downstream hydrological effects of continued glacier wastage can be substantial, but the magnitudes vary greatly among basins and throughout the melt season.

  5. The Influence of Coronal Mass Ejections on the Mass-loss Rates of Hot-Jupiters

    Energy Technology Data Exchange (ETDEWEB)

    Cherenkov, A.; Bisikalo, D. [Institute of Astronomy of the Russian Academy of Sciences, 48 Pyatnitskaya St. 119017, Moscow (Russian Federation); Fossati, L.; Möstl, C., E-mail: bisikalo@inasan.ru [Space Research Institute, Austrian Academy of Sciences, Schmiedlstrasse 6, A-8042 Graz (Austria)

    2017-09-01

    Hot-Jupiters are subject to extreme radiation and plasma flows coming from their host stars. Past ultraviolet Hubble Space Telescope observations, supported by hydrodynamic models, confirmed that these factors lead to the formation of an extended envelope, part of which lies beyond the Roche lobe. We use gas-dynamic simulations to study the impact of time variations in the parameters of the stellar wind, namely that of coronal mass ejections (CMEs), on the envelope of the typical hot-Jupiter HD 209458b. We consider three CMEs characterized by different velocities and densities, taking their parameters from typical CMEs observed for the Sun. The perturbations in the ram-pressure of the stellar wind during the passage of each CME tear off most of the envelope that is located beyond the Roche lobe. This leads to a substantial increase of the mass-loss rates during the interaction with the CME. We find that the mass lost by the planet during the whole crossing of a CME is of ≈10{sup 15} g, regardless of the CME taken into consideration. We also find that over the course of 1 Gyr, the mass lost by the planet because of CME impacts is comparable to that lost because of high-energy stellar irradiation.

  6. A model on CME/Flare initiation: Loss of Equilibrium caused by mass loss of quiescent prominences

    Science.gov (United States)

    Miley, George; Chon Nam, Sok; Kim, Mun Song; Kim, Jik Su

    2015-08-01

    Coronal Mass Ejections (CMEs) model should give an answer to enough energy storage for giant bulk plasma into interplanetary space to escape against the sun’s gravitation and its explosive eruption. Advocates of ‘Mass Loading’ model (e.g. Low, B. 1996, SP, 167, 217) suggested a simple mechanism of CME initiation, the loss of mass from a prominence anchoring magnetic flux rope, but they did not associate the mass loss with the loss of equilibrium. The catastrophic loss of equilibrium model is considered as to be a prospective CME/Flare model to explain sudden eruption of magnetic flux systems. Isenberg, P. A., et al (1993, ApJ, 417, 368)developed ideal magnetohydrodynamic theory of the magnetic flux rope to show occurrence of catastrophic loss of equilibrium according to increasing magnetic flux transported into corona.We begin with extending their study including gravity on prominence’s material to obtain equilibrium curves in case of given mass parameters, which are the strengths of the gravitational force compared with the characteristic magnetic force. Furthermore, we study quasi-static evolution of the system including massive prominence flux rope and current sheet below it to obtain equilibrium curves of prominence’s height according to decreasing mass parameter in a properly fixed magnetic environment. The curves show equilibrium loss behaviors to imply that mass loss result in equilibrium loss. Released fractions of magnetic energy are greater than corresponding zero-mass case. This eruption mechanism is expected to be able to apply to the eruptions of quiescent prominences, which is located in relatively weak magnetic environment with 105 km of scale length and 10G of photospheric magnetic field.

  7. Sharply increased mass loss from glaciers and ice caps in the Canadian Arctic Archipelago.

    Science.gov (United States)

    Gardner, Alex S; Moholdt, Geir; Wouters, Bert; Wolken, Gabriel J; Burgess, David O; Sharp, Martin J; Cogley, J Graham; Braun, Carsten; Labine, Claude

    2011-05-19

    Mountain glaciers and ice caps are contributing significantly to present rates of sea level rise and will continue to do so over the next century and beyond. The Canadian Arctic Archipelago, located off the northwestern shore of Greenland, contains one-third of the global volume of land ice outside the ice sheets, but its contribution to sea-level change remains largely unknown. Here we show that the Canadian Arctic Archipelago has recently lost 61 ± 7 gigatonnes per year (Gt yr(-1)) of ice, contributing 0.17 ± 0.02 mm yr(-1) to sea-level rise. Our estimates are of regional mass changes for the ice caps and glaciers of the Canadian Arctic Archipelago referring to the years 2004 to 2009 and are based on three independent approaches: surface mass-budget modelling plus an estimate of ice discharge (SMB+D), repeat satellite laser altimetry (ICESat) and repeat satellite gravimetry (GRACE). All three approaches show consistent and large mass-loss estimates. Between the periods 2004-2006 and 2007-2009, the rate of mass loss sharply increased from 31 ± 8 Gt yr(-1) to 92 ± 12 Gt yr(-1) in direct response to warmer summer temperatures, to which rates of ice loss are highly sensitive (64 ± 14 Gt yr(-1) per 1 K increase). The duration of the study is too short to establish a long-term trend, but for 2007-2009, the increase in the rate of mass loss makes the Canadian Arctic Archipelago the single largest contributor to eustatic sea-level rise outside Greenland and Antarctica.

  8. Greenland Ice Sheet Mass Balance: Distribution of Increased Mass Loss with Climate Warming; 2003-07 Versus 1992-2002

    Science.gov (United States)

    Zwally, H. Jay; Li, Jun; Benner, Anita C.; Beckley, Matthew; Cornejo, Helen G.; DiMarzio, John; Giovinetto, Mario B.; Neumann, Thomas A.; Robbins, John; Saba, Jack L.; hide

    2011-01-01

    We derive mass changes of the Greenland ice sheet (GIS) for 2003-07 from ICESat laser altimetry and compare them with results for 1992-2002 from ERS radar and airborne laser altimetry. The GIS continued to grow inland and thin at the margins during 2003 07, but surface melting and accelerated flow significantly increased the marginal thinning compared with the 1990s. The net balance changed from a small loss of 7 plus or minus 3 Gt a 1(sup -1) in the 1990s to 171 plus or minus 4 Gt a (sup -1) for 2003-07, contributing 0.5 mm a(sup -1) to recent global sea-level rise. We divide the derived mass changes into two components: (1) from changes in melting and ice dynamics and (2) from changes in precipitation and accumulation rate. We use our firn compaction model to calculate the elevation changes driven by changes in both temperature and accumulation rate and to calculate the appropriate density to convert the accumulation-driven changes to mass changes. Increased losses from melting and ice dynamics (17-206 Gt a(sup-1) are over seven times larger than increased gains from precipitation (10 35 Gt a(sup-1) during a warming period of approximately 2 K (10 a)(sup -1) over the GIS. Above 2000m elevation, the rate of gain decreased from 44 to 28 Gt a(sup-1), while below 2000m the rate of loss increased from 51 to 198 Gt a(sup-1). Enhanced thinning below the equilibrium line on outlet glaciers indicates that increased melting has a significant impact on outlet glaciers, as well as accelerating ice flow. Increased thinning at higher elevations appears to be induced by dynamic coupling to thinning at the margins on decadal timescales.

  9. Limited influence of climate change mitigation on short-term glacier mass loss

    Science.gov (United States)

    Marzeion, Ben; Kaser, Georg; Maussion, Fabien; Champollion, Nicolas

    2018-04-01

    Glacier mass loss is a key contributor to sea-level change1,2, slope instability in high-mountain regions3,4 and the changing seasonality and volume of river flow5-7. Understanding the causes, mechanisms and time scales of glacier change is therefore paramount to identifying successful strategies for mitigation and adaptation. Here, we use temperature and precipitation fields from the Coupled Model Intercomparison Project Phase 5 output to force a glacier evolution model, quantifying mass responses to future climatic change. We find that contemporary glacier mass is in disequilibrium with the current climate, and 36 ± 8% mass loss is already committed in response to past greenhouse gas emissions. Consequently, mitigating future emissions will have only very limited influence on glacier mass change in the twenty-first century. No significant differences between 1.5 and 2 K warming scenarios are detectable in the sea-level contribution of glaciers accumulated within the twenty-first century. In the long-term, however, mitigation will exert strong control, suggesting that ambitious measures are necessary for the long-term preservation of glaciers.

  10. Evolution of thermally pulsing asymptotic giant branch stars. IV. Constraining mass loss and lifetimes of low mass, low metallicity AGB stars

    Energy Technology Data Exchange (ETDEWEB)

    Rosenfield, Philip; Dalcanton, Julianne J.; Weisz, Daniel; Williams, Benjamin F. [Department of Astronomy, University of Washington, Box 351580, Seattle, WA 98195 (United States); Marigo, Paola [Department of Physics and Astronomy G. Galilei, University of Padova, Vicolo dell' Osservatorio 3, I-35122 Padova (Italy); Girardi, Léo; Gullieuszik, Marco [Osservatorio Astronomico di Padova—INAF, Vicolo dell' Osservatorio 5, I-35122 Padova (Italy); Bressan, Alessandro [Astrophysics Sector, SISSA, Via Bonomea 265, I-34136 Trieste (Italy); Dolphin, Andrew [Raytheon Company, 1151 East Hermans Road, Tucson, AZ 85756 (United States); Aringer, Bernhard [Department of Astrophysics, University of Vienna, Turkenschanzstraße 17, A-1180 Wien (Austria)

    2014-07-20

    The evolution and lifetimes of thermally pulsating asymptotic giant branch (TP-AGB) stars suffer from significant uncertainties. In this work, we analyze the numbers and luminosity functions of TP-AGB stars in six quiescent, low metallicity ([Fe/H] ≲ –0.86) galaxies taken from the ACS Nearby Galaxy Survey Treasury sample, using Hubble Space Telescope (HST) photometry in both optical and near-infrared filters. The galaxies contain over 1000 TP-AGB stars (at least 60 per field). We compare the observed TP-AGB luminosity functions and relative numbers of TP-AGB and red giant branch (RGB) stars, N{sub TP-AGB}/N{sub RGB}, to models generated from different suites of TP-AGB evolutionary tracks after adopting star formation histories derived from the HST deep optical observations. We test various mass-loss prescriptions that differ in their treatments of mass loss before the onset of dust-driven winds (pre-dust). These comparisons confirm that pre-dust mass loss is important, since models that neglect pre-dust mass loss fail to explain the observed N{sub TP-AGB}/N{sub RGB} ratio or the luminosity functions. In contrast, models with more efficient pre-dust mass loss produce results consistent with observations. We find that for [Fe/H] ≲ –0.86, lower mass TP-AGB stars (M ≲ 1 M{sub ☉}) must have lifetimes of ∼0.5 Myr and higher masses (M ≲ 3 M{sub ☉}) must have lifetimes ≲ 1.2 Myr. In addition, assuming our best-fitting mass-loss prescription, we show that the third dredge-up has no significant effect on TP-AGB lifetimes in this mass and metallicity range.

  11. The Roles of Tidal Evolution and Evaporative Mass Loss in the Origin of CoRoT-7 b

    Science.gov (United States)

    Jackson, Brian; Miller, Neil; Barnes, Rory; Raymond, Sean N.; Fortney, Jonathan J.; Greenberg, Richard

    2010-01-01

    CoRoT-7 b is the first confirmed rocky exoplanet, but, with an orbital semimajor axis of 0.0172 au, its origins may be unlike any rocky planet in our Solar System. In this study, we consider the roles of tidal evolution and evaporative mass loss in CoRoT-7 b's history, which together have modified the planet's mass and orbit. If CoRoT-7 b has always been a rocky body, evaporation may have driven off almost half its original mass, but the mass loss may depend sensitively on the extent of tidal decay of its orbit. As tides caused CoRoT-7 b's orbit to decay, they brought the planet closer to its host star, thereby enhancing the mass loss rate. Such a large mass loss also suggests the possibility that CoRoT-7 b began as a gas giant planet and had its original atmosphere completely evaporated. In this case, we find that CoRoT-7 b's original mass probably did not exceed 200 Earth masses (about two-third of a Jupiter mass). Tides raised on the host star by the planet may have significantly reduced the orbital semimajor axis, perhaps causing the planet to migrate through mean-motion resonances with the other planet in the system, CoRoT-7 c. The coupling between tidal evolution and mass loss may be important not only for CoRoT-7 b but also for other close-in exoplanets, and future studies of mass loss and orbital evolution may provide insight into the origin and fate of close-in planets, both rocky and gaseous.

  12. Isolated transient loss of consciousness is an indicator of significant injury.

    Science.gov (United States)

    Owings, J T; Wisner, D H; Battistella, F D; Perlstein, J; Walby, W F; Tharratt, R S

    1998-09-01

    To determine if isolated transient loss of consciousness is an indicator of significant injury. University-based level I trauma center. Phase 1 retrospective case series of all patients with trauma admitted directly from the emergency department to the operating room or an intensive care unit who had transient loss of consciousness as their only trauma triage criterion. Phase 2 prospective case series of all trauma patients transported by emergency medical system personnel with transient loss of consciousness as their only trauma triage criterion. Emergency operation and intensive care unit admission. Phase 1: From January 1, 1992, to March 31, 1995, we admitted 10255 patients with trauma. Three hundred seven (3%) met the enrollment criteria and were admitted to the operating room (n = 168) or intensive care unit (n = 139). Of these, 58 (18.9%) were taken to the operating room emergently to manage life-threatening injuries: 11 (4%) had craniotomies and 47 (15%) had non-neurosurgical operations. Phase 2: From July 1 to December 31, 1996, 2770 trauma patients were transported to our facility; 135 (4.9%) met the enrollment criteria. Forty-one (30.4%) of these required admission, and 6 (4.4%) were taken emergently to the operating room from the emergency department (1 [1%] for a craniotomy, 3 [2.2%] for intra-abdominal bleeding, and 2 [1.5%] for other procedures). Two (1.5%) of the 135 patients died. Patients with isolated transient loss of consciousness are at significant risk of critical surgical and neurosurgical injuries. These patients should be triaged to trauma centers or hospitals with adequate imaging, surgical, and neurosurgical resources.

  13. The evolution of massive stars with mass loss: the H- and the He-burning phases

    International Nuclear Information System (INIS)

    Chieffi, Alessandro; Limongi, Marco

    2010-01-01

    The evolution of a massive star to its final fate is strongly modified by the efficient mass loss episodes it experiences during its lifetime. In the following, we will briefly summarize how the H- and the He- burning phases depend on the adopted mass loss rate.

  14. Prognostic significance of unintentional body weight loss in colon cancer patients.

    Science.gov (United States)

    Kuo, Yi-Hung; Shi, Chung-Sheng; Huang, Cheng Yi; Huang, Yun-Ching; Chin, Chih-Chien

    2018-04-01

    The aim of the present study was to investigate whether unintentional body weight loss (BWL) provides additional clinical information in terms of tumor progression and prognosis in non-metastatic colon cancer. In the present study, a total of 2,406 consecutive colon cancer patients without metastasis were retrospectively enrolled. Unintentional BWL was defined as loss of >5% of body weight within the last 6-12 months, or defined subjectively upon fulfillment of at least two of the following: Evidence of change in clothing size and corroboration of the reported weight loss by family or friend. This category was recorded as present ('with') or absent ('without'). Logistic regression analysis was performed to determine the correlation between BWL and the tumor characteristics and post-operative outcomes of patients with colon cancer. The Cox regression model was used to determine the association of BWL with long-term survival of colon cancer patients. A significant association between BWL and tumor location [right vs. left: Odds ratio (OR)=1.62; Pcolon cancer is not just a symptom, but it is also correlated with tumor location, size and depth, and is a prognostic factor for poor outcomes including overall survival and tumor relapse.

  15. Predictors of fat-free mass loss 1 year after laparoscopic sleeve gastrectomy.

    Science.gov (United States)

    Guida, B; Cataldi, M; Busetto, L; Aiello, M L; Musella, M; Capone, D; Parolisi, S; Policastro, V; Ragozini, G; Belfiore, A

    2018-03-24

    Laparoscopic sleeve gastrectomy (LSG) is one of the most frequently performed bariatric surgery interventions because of its safety and efficacy. Nevertheless, concerns have been raised on its detrimental effect on patient nutritional state that can ultimately lead to the loss of fat-free mass (FFM). There is interest in identifying predictors for the early identification of patients at risk of this highly unwanted adverse because they could benefit of nutritional preventive interventions. Therefore, we investigated whether anthropometric parameters, body composition or resting energy expenditure (REE) measured before surgery could predict FFM loss 1 year after LSG. Study design was retrospective observational. We retrieved data on body weight, BMI, body composition and REE before and 1 year after LSG from the medical files of 36 patients operated on by LSG at our institutions. Simple regression, the Oldham's method and multilevel analysis were used to identify predictors of FFM loss. Averaged percentage FFM loss 1 year after LSG was 17.0 ± 7.7% with significant differences between sexes (20.8 ± 6.6 in males and 12.2 ± 6.1% in females, p FFM loss was strongly predicted by pre-surgery FFM and this effect persisted also after correcting for the contribution of sex. High FFM values before surgery predict a more severe FFM loss after LSG. This factor could also account for the higher FFM loss in men than in women. Our finding could help in the early identification of patient requiring a nutritional support after LSG.

  16. Structural changes in the knee during weight loss maintenance after a significant weight loss in obese patients with osteoarthritis

    DEFF Research Database (Denmark)

    Henriksen, M; Christensen, R; Hunter, D J

    2014-01-01

    OBJECTIVE: To compare structural knee joint changes in obese patients with knee osteoarthritis (OA) that after an intensive weight loss therapy were randomized to continuous dietetic support, a specialized knee exercise program, or 'no attention' for 1 year. METHODS: 192 obese individuals with knee...... OA underwent an intensive 16-week weight loss program with subsequent randomization to one of the three treatment groups. Changes in cartilage loss, bone marrow lesions (BMLs), synovitis, and effusion were assessed using semi quantitative assessments of magnetic resonance imaging (MRI) obtained...... (difference: -0.21 [95%CI -0.40:-0.03]) and "no attention" (difference: -0.26 [95%CI -0.44:-0.07]) groups. CONCLUSION: In this 1 year follow-up after weight-loss in obese knee OA patients, we found a potentially increased number of BMLs in the exercise group compared to the diet and no attention groups...

  17. Weight loss significantly reduces serum lipocalin-2 levels in overweight and obese women with polycystic ovary syndrome.

    Science.gov (United States)

    Koiou, Ekaterini; Tziomalos, Konstantinos; Katsikis, Ilias; Kandaraki, Eleni A; Kalaitzakis, Emmanuil; Delkos, Dimitrios; Vosnakis, Christos; Panidis, Dimitrios

    2012-01-01

    Serum lipocalin-2 levels are elevated in obese patients. We assessed serum lipocalin-2 levels in polycystic ovary syndrome (PCOS) and the effects of weight loss or metformin on these levels. Forty-seven overweight/obese patients with PCOS [body mass index (BMI) >27 kg/m(2)] were instructed to follow a low-calorie diet, to exercise and were given orlistat or sibutramine for 6 months. Twenty-five normal weight patients with PCOS (BMI weight and 25 overweight/obese healthy female volunteers comprised the control groups. Serum lipocalin-2 levels did not differ between overweight/obese patients with PCOS and overweight/obese controls (p = 0.258), or between normal weight patients with PCOS and normal weight controls (p = 0.878). Lipocalin-2 levels were higher in overweight/obese patients with PCOS than in normal weight patients with PCOS (p weight loss resulted in a fall in lipocalin-2 levels (p weight patients with PCOS, treatment with metformin did not affect lipocalin-2 levels (p = 0.484). In conclusion, PCOS per se is not associated with elevated lipocalin-2 levels. Weight loss induces a significant reduction in lipocalin-2 levels in overweight/obese patients with PCOS.

  18. Luminosities and mass-loss rates of Local Group AGB stars and red supergiants

    Science.gov (United States)

    Groenewegen, M. A. T.; Sloan, G. C.

    2018-01-01

    Context. Mass loss is one of the fundamental properties of asymptotic giant branch (AGB) stars, and through the enrichment of the interstellar medium, AGB stars are key players in the life cycle of dust and gas in the universe. However, a quantitative understanding of the mass-loss process is still largely lacking. Aims: We aim to investigate mass loss and luminosity in a large sample of evolved stars in several Local Group galaxies with a variety of metalliticies and star-formation histories: the Small and Large Magellanic Cloud, and the Fornax, Carina, and Sculptor dwarf spheroidal galaxies (dSphs). Methods: Dust radiative transfer models are presented for 225 carbon stars and 171 oxygen-rich evolved stars in several Local Group galaxies for which spectra from the Infrared Spectrograph on Spitzer are available. The spectra are complemented with available optical and infrared photometry to construct spectral energy distributions. A minimization procedure was used to determine luminosity and mass-loss rate (MLR). Pulsation periods were derived for a large fraction of the sample based on a re-analysis of existing data. Results: New deep K-band photometry from the VMC survey and multi-epoch data from IRAC (at 4.5 μm) and AllWISE and NEOWISE have allowed us to derive pulsation periods longer than 1000 days for some of the most heavily obscured and reddened objects. We derive (dust) MLRs and luminosities for the entire sample. The estimated MLRs can differ significantly from estimates for the same objects in the literature due to differences in adopted optical constants (up to factors of several) and details in the radiative transfer modelling. Updated parameters for the super-AGB candidate MSX SMC 055 (IRAS 00483-7347) are presented. Its current mass is estimated to be 8.5 ± 1.6 M⊙, suggesting an initial mass well above 8 M⊙ in agreement with estimates based on its large Rubidium abundance. Using synthetic photometry, we present and discuss colour-colour and

  19. Difficulty eating and significant weight loss in joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type.

    Science.gov (United States)

    Baeza-Velasco, Carolina; Van den Bossche, Thomas; Grossin, Daniel; Hamonet, Claude

    2016-06-01

    Joint Hypermobility Syndrome, also known as Ehlers-Danlos Syndrome Hypermobility Type (JHS/EDS-HT), is a heritable disorder of connective tissue, common but poorly known by the medical community. Although generalized joint hypermobility and fragility of tissues have been described as core features, recent research highlights the multisystemic nature of JHS/EDS-HT, which presents with a wide range of articular and extra-articular symptoms. Among these, gastrointestinal problems, temporomandibular disorders, and smell and taste abnormalities are common among those affected, having significant implications for eating. The present work reviews the literature linking JHS/EDS-HT and eating problems. Two illustrative case reports, in which JHS/EDS-HT manifestations contribute to developing and maintaining disturbed eating behaviors and significant weight loss, are presented.

  20. Significant Weight Loss, Nausea, And Vomiting Due to Strongyloidiasis:A Case Report

    Directory of Open Access Journals (Sweden)

    Afshin Shafaghi

    2008-11-01

    Full Text Available Strongyloidiasis is caused by infestation with Strongyloides stercoralis, a free living tropical and semitropical soil helminth that has a larval form that penetrates intact skin.Clinical manifestations may be varied from an asymptomatic infection   in immunocompetent hosts to a diffuse and fatal form in immunocompromised hosts.We report a 56-year-old man from Dezful (south-west of Iran with a 6-month history of nausea, vomiting and significant weight loss (greater than 10%. Abdominal ltrasonography had no significant findings. Upper gastrointestinal series and abdominal CT were performed. Dilated bowel loops especially in the jejunum,with decreased mucosal folds were seen. Abiopsy specimen from the third part of duodenum showed strongyloides larvae,thus albendazole 400 mg twice a day for 3   days was initiated.He responded well to this treatment regimen.  

  1. Modelling historical and recent mass loss of McCall Glacier, Alaska, USA

    Directory of Open Access Journals (Sweden)

    C. Delcourt

    2008-03-01

    Full Text Available Volume loss of valley glaciers is now considered to be a significant contribution to sea level rise. Understanding and identifying the processes involved in accelerated mass loss are necessary to determine their impact on the global system. Here we present results from a series of model experiments with a higher-order thermomechanically coupled flowline model (Pattyn, 2002. Boundary conditions to the model are parameterizations of surface mass balance, geothermal heating, observed surface and 10 m ice depth temperatures. The time-dependent experiments aim at simulating the glacier retreat from its LIA expansion to present according to different scenarios and model parameters. Model output was validated against measurements of ice velocity, ice surface elevation and terminus position at different stages. Results demonstrate that a key factor in determining the glacier retreat history is the importance of internal accumulation (>50% in the total mass balance. The persistence of a basal temperate zone characteristic for this polythermal glacier depends largely on its contribution. Accelerated glacier retreat since the early nineties seems directly related to the increase in ELA and the sudden reduction in AAR due to the fact that a large lower elevation cirque – previously an important accumulation area – became part of the ablation zone.

  2. Nitrogen losses from dairy manure estimated through nitrogen mass balance and chemical markers

    Science.gov (United States)

    Hristov, Alexander N.; Zaman, S.; Vander Pol, M.; Ndegwa, P.; Campbell, L.; Silva, S.

    2009-01-01

    Ammonia is an important air and water pollutant, but the spatial variation in its concentrations presents technical difficulties in accurate determination of ammonia emissions from animal feeding operations. The objectives of this study were to investigate the relationship between ammonia volatilization and ??15N of dairy manure and the feasibility of estimating ammonia losses from a dairy facility using chemical markers. In Exp. 1, the N/P ratio in manure decreased by 30% in 14 d as cumulative ammonia losses increased exponentially. Delta 15N of manure increased throughout the course of the experiment and ??15N of emitted ammonia increased (p < 0.001) quadratically from -31??? to -15 ???. The relationship between cumulative ammonia losses and ??15N of manure was highly significant (p < 0.001; r2 = 0.76). In Exp. 2, using a mass balance approach, approximately half of the N excreted by dairy cows (Bos taurus) could not be accounted for in 24 h. Using N/P and N/K ratios in fresh and 24-h manure, an estimated 0.55 and 0.34 (respectively) of the N excreted with feces and urine could not be accounted for. This study demonstrated that chemical markers (P, K) can be successfully used to estimate ammonia losses from cattle manure. The relationship between manure ??15N and cumulative ammonia loss may also be useful for estimating ammonia losses. Although promising, the latter approach needs to be further studied and verified in various experimental conditions and in the field. Copyright ?? 2009 by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America. All rights reserved.

  3. Documentation of Significant Losses in Cornus florida L. Populations throughout the Appalachian Ecoregion

    International Nuclear Information System (INIS)

    Oswalt, Ch.M.; Oswalt, S.N.

    2010-01-01

    Over the last three decades the fungus Discula destructiva Redlin has severely impacted Cornus florida L. (flowering dogwood hereafter dogwood) populations throughout its range. This study estimates historical and current dogwood populations (number of trees) across the Appalachian ecoregion. Objectives were to (1) quantify current dogwood populations in the Appalachian eco region, (2) quantify change over time in dogwood populations, and (3) identify trends in dogwood population shifts. Data from the USDA Forest Service Forest Inventory and Analysis (FIA) database were compiled from 41 FIA units in 13 states for county-level estimates of the total number of all live dogwood trees on timberland within the Appalachian eco region. Analysis of covariance, comparing historical and current county-level dogwood population estimates with average change in forest density as the covariate, was used to identify significant changes within FIA units. Losses ranging from 25 to 100 percent of the sample population (ρ<.05) were observed in 33 of the 41 (80 percent) sampled FIA units. These results indicate that an important component of the eastern deciduous forest has experienced serious losses throughout the Appalachians and support localized empirical results and landscape-scale anecdotal evidence.

  4. Documentation of Significant Losses in Cornus florida L. Populations throughout the Appalachian Ecoregion

    Directory of Open Access Journals (Sweden)

    Christopher M. Oswalt

    2010-01-01

    Full Text Available Over the last three decades the fungus Discula destructiva Redlin has severely impacted Cornus florida L. (flowering dogwood—hereafter “dogwood” populations throughout its range. This study estimates historical and current dogwood populations (number of trees across the Appalachian ecoregion. Objectives were to (1 quantify current dogwood populations in the Appalachian ecoregion, (2 quantify change over time in dogwood populations, and (3 identify trends in dogwood population shifts. Data from the USDA Forest Service Forest Inventory and Analysis (FIA database were compiled from 41 FIA units in 13 states for county-level estimates of the total number of all live dogwood trees on timberland within the Appalachian ecoregion. Analysis of covariance, comparing historical and current county-level dogwood population estimates with average change in forest density as the covariate, was used to identify significant changes within FIA units. Losses ranging from 25 to 100 percent of the sample population (<.05 were observed in 33 of the 41 (80 percent sampled FIA units. These results indicate that an important component of the eastern deciduous forest has experienced serious losses throughout the Appalachians and support localized empirical results and landscape-scale anecdotal evidence.

  5. Evolution of massive stars with mass loss: surface abundances

    International Nuclear Information System (INIS)

    Greggio, L.

    1984-01-01

    The location of theoretical stellar models in the upper part of the Hertzsprung-Russell diagram depends on a variety of poorly understood physical processes which may occur during the evolution of massive stars. The comparison between theoretical predictions and observations of the surface chemical composition of these objects can help in understanding their evolution and to set more stringent limits to the mentioned parameters. To this end, evolutionary sequences corresponding to 20, 40 and 60 solar masses have been computed up to core He exhaustion, following in detail the abundance variations of CNO, Ne and Mg isotopes. (Auth.)

  6. Mass loss due to gravitational waves with Λ > 0

    Science.gov (United States)

    Saw, Vee-Liem

    2017-07-01

    The theoretical basis for the energy carried away by gravitational waves that an isolated gravitating system emits was first formulated by Hermann Bondi during the ’60s. Recent findings from the observation of distant supernovae revealed that the rate of expansion of our universe is accelerating, which may be well explained by sticking a positive cosmological constant into the Einstein field equations for general relativity. By solving the Newman-Penrose equations (which are equivalent to the Einstein field equations), we generalize this notion of Bondi mass-energy and thereby provide a firm theoretical description of how an isolated gravitating system loses energy as it radiates gravitational waves, in a universe that expands at an accelerated rate. This is in line with the observational front of LIGO’s first announcement in February 2016 that gravitational waves from the merger of a binary black hole system have been detected.

  7. The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice

    International Nuclear Information System (INIS)

    Hamrick, Mark W.; Herberg, Samuel; Arounleut, Phonepasong; He, Hong-Zhi; Shiver, Austin; Qi, Rui-Qun; Zhou, Li; Isales, Carlos M.

    2010-01-01

    Research highlights: → Aging is associated with muscle atrophy and loss of muscle mass, known as the sarcopenia of aging. → We demonstrate that age-related muscle atrophy is associated with marked changes in miRNA expression in muscle. → Treating aged mice with the adipokine leptin significantly increased muscle mass and the expression of miRNAs involved in muscle repair. → Recombinant leptin therapy may therefore be a novel approach for treating age-related muscle atrophy. -- Abstract: Age-associated loss of muscle mass, or sarcopenia, contributes directly to frailty and an increased risk of falls and fractures among the elderly. Aged mice and elderly adults both show decreased muscle mass as well as relatively low levels of the fat-derived hormone leptin. Here we demonstrate that loss of muscle mass and myofiber size with aging in mice is associated with significant changes in the expression of specific miRNAs. Aging altered the expression of 57 miRNAs in mouse skeletal muscle, and many of these miRNAs are now reported to be associated specifically with age-related muscle atrophy. These include miR-221, previously identified in studies of myogenesis and muscle development as playing a role in the proliferation and terminal differentiation of myogenic precursors. We also treated aged mice with recombinant leptin, to determine whether leptin therapy could improve muscle mass and alter the miRNA expression profile of aging skeletal muscle. Leptin treatment significantly increased hindlimb muscle mass and extensor digitorum longus fiber size in aged mice. Furthermore, the expression of 37 miRNAs was altered in muscles of leptin-treated mice. In particular, leptin treatment increased the expression of miR-31 and miR-223, miRNAs known to be elevated during muscle regeneration and repair. These findings suggest that aging in skeletal muscle is associated with marked changes in the expression of specific miRNAs, and that nutrient-related hormones such as leptin

  8. The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice

    Energy Technology Data Exchange (ETDEWEB)

    Hamrick, Mark W., E-mail: mhamrick@mail.mcg.edu [Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); Department of Orthopaedic Surgery, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); Herberg, Samuel; Arounleut, Phonepasong [Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); Department of Orthopaedic Surgery, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); He, Hong-Zhi [Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI (United States); Department of Dermatology, Henry Ford Health System, Detroit, MI (United States); Shiver, Austin [Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); Department of Orthopaedic Surgery, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); Qi, Rui-Qun [Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI (United States); Department of Dermatology, Henry Ford Health System, Detroit, MI (United States); Zhou, Li [Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI (United States); Department of Dermatology, Henry Ford Health System, Detroit, MI (United States); Department of Internal Medicine, Henry Ford Health System, Detroit, MI (United States); Isales, Carlos M. [Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); Department of Orthopaedic Surgery, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA (United States); others, and

    2010-09-24

    Research highlights: {yields} Aging is associated with muscle atrophy and loss of muscle mass, known as the sarcopenia of aging. {yields} We demonstrate that age-related muscle atrophy is associated with marked changes in miRNA expression in muscle. {yields} Treating aged mice with the adipokine leptin significantly increased muscle mass and the expression of miRNAs involved in muscle repair. {yields} Recombinant leptin therapy may therefore be a novel approach for treating age-related muscle atrophy. -- Abstract: Age-associated loss of muscle mass, or sarcopenia, contributes directly to frailty and an increased risk of falls and fractures among the elderly. Aged mice and elderly adults both show decreased muscle mass as well as relatively low levels of the fat-derived hormone leptin. Here we demonstrate that loss of muscle mass and myofiber size with aging in mice is associated with significant changes in the expression of specific miRNAs. Aging altered the expression of 57 miRNAs in mouse skeletal muscle, and many of these miRNAs are now reported to be associated specifically with age-related muscle atrophy. These include miR-221, previously identified in studies of myogenesis and muscle development as playing a role in the proliferation and terminal differentiation of myogenic precursors. We also treated aged mice with recombinant leptin, to determine whether leptin therapy could improve muscle mass and alter the miRNA expression profile of aging skeletal muscle. Leptin treatment significantly increased hindlimb muscle mass and extensor digitorum longus fiber size in aged mice. Furthermore, the expression of 37 miRNAs was altered in muscles of leptin-treated mice. In particular, leptin treatment increased the expression of miR-31 and miR-223, miRNAs known to be elevated during muscle regeneration and repair. These findings suggest that aging in skeletal muscle is associated with marked changes in the expression of specific miRNAs, and that nutrient

  9. The Role of the North Atlantic Oscillation (NAO) on Recent Greenland Surface Mass Loss and Mass Partitioning

    Science.gov (United States)

    Tedesco, M.; Alexander, P.; Porter, D. F.; Fettweis, X.; Luthcke, S. B.; Mote, T. L.; Rennermalm, A.; Hanna, E.

    2017-12-01

    Despite recent changes in Greenland surface mass losses and atmospheric circulation over the Arctic, little attention has been given to the potential role of large-scale atmospheric processes on the spatial and temporal variability of mass loss and partitioning of the GrIS mass loss. Using a combination of satellite gravimetry measurements, outputs of the MAR regional climate model and reanalysis data, we show that changes in atmospheric patterns since 2013 over the North Atlantic region of the Arctic (NAA) modulate total mass loss trends over Greenland together with the spatial and temporal distribution of mass loss partitioning. For example, during the 2002 - 2012 period, melting persistently increased, especially along the west coast, as a consequence of increased insulation and negative NAO conditions characterizing that period. Starting in 2013, runoff along the west coast decreased while snowfall increased substantially, when NAO turned to a more neutral/positive state. Modeled surface mass balance terms since 1950 indicate that part of the GRACE-period, specifically the period between 2002 and 2012, was exceptional in terms of snowfall over the east and northeast regions. During that period snowfall trend decreased to almost 0 Gt/yr from a long-term increasing trend, which presumed again in 2013. To identify the potential impact of atmospheric patterns on mass balance and its partitioning, we studied the spatial and temporal correlations between NAO and snowfall/runoff. Our results indicate that the correlation between summer snowfall and NAO is not stable during the 1950 - 2015 period. We further looked at changes in patterns of circulation using self organizing maps (SOMs) to identify the atmospheric patterns characterizing snowfall during different periods. We discuss potential implications for past changes and future GCM and RCM simulations.

  10. The role of pyridoxine as a countermeasure for in-flight loss of lean body mass

    Science.gov (United States)

    Gilbert, Joyce A.

    1992-01-01

    Ground based and in flight research has shown that humans, under conditions of microgravity, sustain a loss of lean body tissue (protein) and changes in several biological processes including, reductions in red blood cell mass, and neurotransmitters. The maintenance of muscle mass, the major component of lean body mass, is required to meet the needs of space station EVAs. Central to the biosynthesis of amino acids, the building blocks of protein, is pyridoxine (vitamin B-6). Muscle mass integrity requires the availability of vitamin B-6 for protein metabolism and neurotransmitter synthesis. Furthermore, the formation of red blood cells require pyridoxine as a cofactor in the biosynthesis of hemoglobin, a protein that carries oxygen to tissues. In its active form, pyridoxal-5'-phosphate (PLP), vitamin B-6 serves as a link between amino acid and carbohydrate metabolism through intermediates of glycolysis and the tricarboxylic acid cycle. In addition to its role in energy metabolism, PLP is involved in the biosynthesis of hemoglobin and neurotransmitter which are necessary for neurological functions. Alterations in pyridoxine metabolism may affect countermeasures designed to overcome some of these biochemical changes. The focus of this research is to determine the effects of microgravity on the metabolic utilization of vitamin B-6, integrating nutrition as an integral component of the countermeasure (exercise) to maintain lean body mass and muscle strength. The objectives are: 1) to determine whether microgravity effects the metabolic utilization of pyridoxine and 2) to quantitate changes in B-6 vitamer distribution in tissue and excreta relative to loss of lean body tissue. The rationale for this study encompasses the unique challenge to control biochemical mechanisms effected during space travel and the significance of pyridoxine to maintain and counter muscle integrity for EVA activities. This experiment will begin to elucidate the importance of biochemical

  11. Mass-loss Rates from Coronal Mass Ejections: A Predictive Theoretical Model for Solar-type Stars

    Energy Technology Data Exchange (ETDEWEB)

    Cranmer, Steven R. [Department of Astrophysical and Planetary Sciences, Laboratory for Atmospheric and Space Physics, University of Colorado, Boulder, CO 80309 (United States)

    2017-05-10

    Coronal mass ejections (CMEs) are eruptive events that cause a solar-type star to shed mass and magnetic flux. CMEs tend to occur together with flares, radio storms, and bursts of energetic particles. On the Sun, CME-related mass loss is roughly an order of magnitude less intense than that of the background solar wind. However, on other types of stars, CMEs have been proposed to carry away much more mass and energy than the time-steady wind. Earlier papers have used observed correlations between solar CMEs and flare energies, in combination with stellar flare observations, to estimate stellar CME rates. This paper sidesteps flares and attempts to calibrate a more fundamental correlation between surface-averaged magnetic fluxes and CME properties. For the Sun, there exists a power-law relationship between the magnetic filling factor and the CME kinetic energy flux, and it is generalized for use on other stars. An example prediction of the time evolution of wind/CME mass-loss rates for a solar-mass star is given. A key result is that for ages younger than about 1 Gyr (i.e., activity levels only slightly higher than the present-day Sun), the CME mass loss exceeds that of the time-steady wind. At younger ages, CMEs carry 10–100 times more mass than the wind, and such high rates may be powerful enough to dispel circumstellar disks and affect the habitability of nearby planets. The cumulative CME mass lost by the young Sun may have been as much as 1% of a solar mass.

  12. Impaired physical function, loss of muscle mass and assessment of biomechanical properties in critical ill patients

    DEFF Research Database (Denmark)

    Poulsen, Jesper Brøndum

    2012-01-01

    Intensive care unit (ICU) admission is associated with muscle weakness and ICU survivors report sustained limitation of physical capacity for years after discharge. Limited information is available on the underlying biomechanical properties responsible for this muscle function impairment. A plaus......Intensive care unit (ICU) admission is associated with muscle weakness and ICU survivors report sustained limitation of physical capacity for years after discharge. Limited information is available on the underlying biomechanical properties responsible for this muscle function impairment....... A plausible contributor to the accentuated catabolic drive in ICU patients is a synergistic response to inflammation and inactivity leading to loss of muscle mass. As these entities are predominantly present in the early phase of ICU stay, interventions employed during this time frame may exhibit the greatest...... potential to counteract loss of muscle mass. Despite the obvious clinical significance of muscle atrophy for the functional impairment observed in ICU survivors, no preventive therapies have been identified as yet. The overall aim of the present dissertation is to characterize aspects of physical function...

  13. Equation of Motion of an Interstellar Bussard Ramjet with Radiation and Mass Losses

    Science.gov (United States)

    Semay, Claude; Silvestre-Brac, Bernard

    2008-01-01

    An interstellar Bussard ramjet is a spaceship using the protons of the interstellar medium in a fusion engine to produce thrust. In recent papers, it was shown that the relativistic equation of motion of an ideal ramjet and that of a ramjet with radiation loss are analytical. When a mass loss appears, the limit speed of the ramjet is more strongly…

  14. Mass loss from OH/IR stars - Models for the infrared emission of circumstellar dust shells

    Science.gov (United States)

    Justtanont, K.; Tielens, A. G. G. M.

    1992-01-01

    The IR emission of a sample of 24 OH/IR stars is modeled, and the properties of circumstellar dust and mass-loss rate of the central star are derived. It is shown that for some sources the observations of the far-IR emission is well fitted with a lambda exp -1 law, while some have a steeper index of 1.5. For a few sources, the presence of circumstellar ice grains is inferred from detailed studies of the observed 10-micron feature. Dust mass-loss rates are determined from detailed studies for all the stars in this sample. They range from 6.0 x 10 exp -10 solar mass/yr for an optically visible Mira to 2.2 x 10 exp -6 solar mass/yr for a heavily obscured OH/IR star. These dust mass-loss rates are compared to those calculated from IRAS photometry using 12-, 25-, and 60-micron fluxes. The dust mass-loss rates are also compared to gas mass-loss rates determined from OH and CO observations. For stars with tenuous shells, a dust-to-gas ratio of 0.001 is obtained.

  15. Massive stars evolution with mass-loss. 20-100 M(sun) models

    Energy Technology Data Exchange (ETDEWEB)

    Chiosi, C; Sreenivasan, S R [Calgary Univ., Alberta (Canada). Dept. of Physics; Nasi, E [Padua Univ. (Italy). Istituto di Astronomia

    1978-02-01

    The evolution of stars with initial masses 20, 30, 40, 60, 80, 100 M(sun) and Population I chemical composition (X = 0.700, Z = 0.02) is calculated, taking into account mass-loss due to stellar winds, from the main sequence up to the early stages of central He-burning. This study incorporates mass-loss rates predicted by the theory of Castor et al. (1975) for the early type phases and a novel way of treating mass-loss rates due to acoustic energy flux driven winds in the later stages analogous to the work of Fusi-Pecci and Renzini (1975a). The results are presented in terms of evolutionary tracks, isochrones, loci of constant mass-loss rates and loci of constant mass in the HR diagram. The effects of mass-loss on the internal structure of the models as well as on the occurrence of semiconvection are also investigated. A detailed comparison of the theoretical predictions and observational results is made and possible implications for O, Of, Wolf-Rayet stars and red supergiants are brought out.

  16. DUST PRODUCTION AND MASS LOSS IN THE GALACTIC GLOBULAR CLUSTER NGC 362

    International Nuclear Information System (INIS)

    Boyer, Martha L.; Gordon, Karl D.; Meixner, Margaret; Sewilo, Marta; Shiao, Bernie; Whitney, Barbara; McDonald, Iain; Van Loon, Jacco Th.; Oliveira, Joana M.; Babler, Brian; Bracker, Steve; Meade, Marilyn; Block, Miwa; Engelbracht, Charles; Misselt, Karl; Hora, Joe; Indebetouw, Remy

    2009-01-01

    We investigate dust production and stellar mass loss in the Galactic globular cluster NGC 362. Due to its close proximity to the Small Magellanic Cloud (SMC), NGC 362 was imaged with the Infrared Array Camera and Multiband Imaging Photometer cameras onboard the Spitzer Space Telescope as part of the Surveying the Agents of Galaxy Evolution (SAGE-SMC) Spitzer Legacy program. We detect several cluster members near the tip of the red giant branch (RGB) that exhibit infrared excesses indicative of circumstellar dust and find that dust is not present in measurable quantities in stars below the tip of the RGB. We modeled the spectral energy distribution (SED) of the stars with the strongest IR excess and find a total cluster dust mass-loss rate of 3.0 +2.0 -1.2 x 10 -9 M sun yr -1 , corresponding to a gas mass-loss rate of 8.6 +5.6 -3.4 x 10 -6 M sun yr -1 , assuming [Fe/H] =-1.16. This mass loss is in addition to any dustless mass loss that is certainly occurring within the cluster. The two most extreme stars, variables V2 and V16, contribute up to 45% of the total cluster dust-traced mass loss. The SEDs of the more moderate stars indicate the presence of silicate dust, as expected for low-mass, low-metallicity stars. Surprisingly, the SED shapes of the stars with the strongest mass-loss rates appear to require the presence of amorphous carbon dust, possibly in combination with silicate dust, despite their oxygen-rich nature. These results corroborate our previous findings in ω Centauri.

  17. SYNTHETIC AGB EVOLUTION .3. THE INFLUENCE OF DIFFERENT MASS-LOSS LAWS

    NARCIS (Netherlands)

    GROENEWEGEN, MAT; DEJONG, T

    In Paper I of this series we presented a model to calculate in a synthetic way the evolution of thermal-pulsing AGB stars. The model was applied to the LMC and values were derived for the minimum core mass for third dredge-up and the dredge-up efficiency. In Paper I mass loss on the AGB was

  18. Accelerated mass loss from Greenland ice sheet : Links to atmospheric circulation in the North Atlantic

    NARCIS (Netherlands)

    Seo, Ki-Weon; Waliser, Duane E.; Lee, Choon-Ki; Tian, Baijun; Scambos, Ted; Kim, Baek-Min; van Angelen, Jan H.; van den Broeke, Michiel R.

    Understanding the mechanisms that drive the mass imbalance of the Greenland ice sheet (GrIS) is critical to the accurate projection of its contribution to future sea level rise. Greenland's ice mass loss has been accelerating recently. Using satellite Earth-gravity and regional climate model data,

  19. Isotopes of carbon, nitrogen and oxygen as probes of nucleosynthesis, stellar mass losses and galactic evolution

    International Nuclear Information System (INIS)

    Audouze, J.; Lequeux, J.; Vigroux, L.

    1975-01-01

    Evidences for a 12 C/ 13 C ratio different in the interstellar medium and in the solar system (40 instead of 89) and for a large N/O ratio in the centers of galaxies are reviewed and are explained by an enrichment of the interstellar medium in 13 C and N by mass loss of stars of various masses [fr

  20. Discovery of CDH23 as a Significant Contributor to Progressive Postlingual Sensorineural Hearing Loss in Koreans.

    Directory of Open Access Journals (Sweden)

    Bong Jik Kim

    Full Text Available CDH23 mutations have mostly been associated with prelingual severe-to-profound sensorineural hearing loss (SNHL in either syndromic or nonsyndromic SNHL (DFNB12. Herein, we demonstrate the contribution of CDH23 mutations to postlingual nonsyndromic SNHL (NS-SNHL. We screened 32 Korean adult probands with postlingual NS-SNHL sporadically or in autosomal recessive fashion using targeted panel or whole exome sequencing. We identified four (12.5%, 4/32 potential postlingual DFNB12 families that segregated the recessive CDH23 variants, qualifying for our criteria along with rapidly progressive SNHL. Three of the four families carried one definite pathogenic CDH23 variant previously known as the prelingual DFNB12 variant in a trans configuration with rare CDH23 variants. To determine the contribution of rare CDH23 variants to the postlingual NS-SNHL, we checked the minor allele frequency (MAF of CDH23 variants detected from our postlingual NS-SNHL cohort and prelingual NS-SNHL cohort, among the 2040 normal control chromosomes. The allele frequency of these CDH23 variants in our postlingual cohort was 12.5%, which was significantly higher than that of the 2040 control chromosomes (5.53%, confirming the contribution of these rare CDH23 variants to postlingual NS-SNHL. Furthermore, MAF of rare CDH23 variants from the postlingual NS-SNHL group was significantly higher than that from the prelingual NS-SNHL group. This study demonstrates an important contribution of CDH23 mutations to poslingual NS-SNHL and shows that the phenotypic spectrum of DFNB12 can be broadened even into the presbycusis, depending on the pathogenic potential of variants. We also propose that pathogenic potential of CDH23 variants and the clinical fate of DFNB12 may be predicted by MAF.

  1. The loss of skeletal muscle strength, mass, and quality in older adults : the health, aging and body composition study

    NARCIS (Netherlands)

    Goodpaster, Bret H; Park, Seok Won; Harris, Tamara B; Kritchevsky, Steven B; Nevitt, Michael; Schwartz, Ann V; Simonsick, Eleanor M; Tylavsky, Frances A; Visser, Marjolein; Newman, Anne B

    2006-01-01

    BACKGROUND: The loss of muscle mass is considered to be a major determinant of strength loss in aging. However, large-scale longitudinal studies examining the association between the loss of mass and strength in older adults are lacking. METHODS: Three-year changes in muscle mass and strength were

  2. The influence of mood on the perception of hearing-loss related quality of life in people with hearing loss and their significant others.

    Science.gov (United States)

    Preminger, Jill E; Meeks, Suzanne

    2010-04-01

    The purpose of this research was to investigate the congruent/incongruent perceptions of hearing-loss related quality of life between members of couples and to determine how incongruence was affected by individual psychosocial characteristics, specifically measures of mood (negative affect and positive affect), stress, and communication in the marriage. An exploratory correlational analysis was performed on data for 52 couples in which only one member had a hearing loss. In the regression analyses the independent variables were hearing-loss related quality of life scores measured in people with hearing loss, measured in significant others, and differences in hearing-loss related quality of life among members of a couple. The results demonstrate that both in people with hearing loss and their significant others, perceptions of hearing-loss related quality of life is highly correlated with negative mood scores. Incongruence in hearing-loss related quality of life scores reported by members of a couple were highly correlated with negative affect measured within each individual. Future research evaluating the effectiveness of audiologic rehabilitation can use measures of mood as an outcome variable.

  3. Evolution of Mass Functions of Coeval Stars through Wind Mass Loss and Binary Interactions

    NARCIS (Netherlands)

    Schneider, F.R.N.; Izzard, R.G.; Langer, N.; de Mink, S.E.

    2015-01-01

    Accurate determinations of stellar mass functions and ages of stellar populations are crucial to much of astrophysics. We analyze the evolution of stellar mass functions of coeval main-sequence stars, including all relevant aspects of single and binary star evolution. We show that the slope of the

  4. Premature loss of muscle mass and function in type 2 diabetes.

    Science.gov (United States)

    Guerrero, N; Bunout, D; Hirsch, S; Barrera, G; Leiva, L; Henríquez, S; De la Maza, M P

    2016-07-01

    Muscle mass and function are among the most relevant factors that contribute to an optimal quality of life, and are strong predictors of mortality in the elderly. Loss of lean tissues and deterioration of muscle function have been described as one of the many complications of type 2 diabetes mellitus (DM2), but most studies do not isolate age as an intervening factor. To study whether adult DM2 patients up to 60years of age have decreased muscle mass and function compared with healthy non-diabetic (ND) subjects of similar age. Appendicular fat-free mass (ApFFM) by dual X-ray absorptiometry (DEXA), handgrip strength (HS), quadriceps strength (QS), 12 min walking capacity (12MW) and the Timed Up and Go test (TUG) were measured in 100 DM2 patients and 39 ND controls. Muscle quality, or the ratio between lean mass and muscle strength of upper and lower limbs, and the functional limitations associated with pain and stiffness assessed according to the Western Ontario and McMaster Universities Arthrosis Index (WOMAC) were also recorded. Specific tests were performed to rule out microvascular diabetic complications (retinal and peripheral nerves), metabolic control, kidney function and vitamin D status and examine their association with ApFFM and function. ApFFM was significantly higher among DM2 female patients and lower among diabetic men. However opposite results were obtained when individual values were corrected for body mass index (BMI), specifically among women, who were more likely to be obese. As for muscle strength and global functionality tests, significantly better performances in TUG, 12MW, QS and HS were observed among ND subjects of both sexes. These differences prevailed even after excluding diabetic patients with microvascular complications as well as those with more than 10years of diabetes. Muscle quality was also significantly better among ND women. Higher scores of pain and stiffness in the WOMAC scale correlated with 12MW and TUG in both groups but

  5. PULSATION-TRIGGERED MASS LOSS FROM AGB STARS: THE 60 DAY CRITICAL PERIOD

    International Nuclear Information System (INIS)

    McDonald, I.; Zijlstra, A. A.

    2016-01-01

    Low- and intermediate-mass stars eject much of their mass during the late, red giant branch (RGB) phase of evolution. The physics of their strong stellar winds is still poorly understood. In the standard model, stellar pulsations extend the atmosphere, allowing a wind to be driven through radiation pressure on condensing dust particles. Here, we investigate the onset of the wind, using nearby RGB stars drawn from the Hipparcos catalog. We find a sharp onset of dust production when the star first reaches a pulsation period of 60 days. This approximately coincides with the point where the star transitions to the first overtone pulsation mode. Models of the spectral energy distributions show stellar mass-loss rate suddenly increasing at this point, by a factor of ∼10 over the existing (chromospherically driven) wind. The dust emission is strongly correlated with both pulsation period and amplitude, indicating stellar pulsation is the main trigger for the strong mass loss, and determines the mass-loss rate. Dust emission does not strongly correlate with stellar luminosity, indicating radiation pressure on dust has little effect on the mass-loss rate. RGB stars do not normally appear to produce dust, whereas dust production by asymptotic giant branch stars appears commonplace, and is probably ubiquitous above the RGB-tip luminosity. We conclude that the strong wind begins with a step change in mass-loss rate and is triggered by stellar pulsations. A second rapid mass-loss-rate enhancement is suggested when the star transitions to the fundamental pulsation mode at a period of ∼300 days.

  6. Antarctic Mass Loss from GRACE from Space- and Time-Resolved Modeling with Slepian Functions

    Science.gov (United States)

    Simons, F. J.; Harig, C.

    2013-12-01

    The melting of polar ice sheets is a major contributor to global sea-level rise. Antarctica is of particular interest since most of the mass loss has occurred in West Antarctica, however updated glacial isostatic adjustment (GIA) models and recent mass gains in East Antarctica have reduced the continent-wide integrated decadal trend of mass loss. Here we present a spatially and temporally resolved estimation of the Antarctic ice mass change using Slepian localization functions. With a Slepian basis specifically for Antarctica, the basis functions maximize their energy on the continent and we can project the geopotential fields into a sparse set of orthogonal coefficients. By fitting polynomial functions to the limited basis coefficients we maximize signal-to-noise levels and need not perform smoothing or destriping filters common to other approaches. In addition we determine an empirical noise covariance matrix from the GRACE data to estimate the uncertainty of mass estimation. When applied to large ice sheets, as in our own recent Greenland work, this technique is able to resolve both the overall continental integrated mass trend, as well as the spatial distribution of the mass changes over time. Using CSR-RL05 GRACE data between Jan. 2003 and Jan 2013, we estimate the regional accelerations in mass change for several sub-regions and examine how the spatial pattern of mass has changed. The Amundsen Sea coast of West Antarctica has experienced a large acceleration in mass loss (-26 Gt/yr^2). While mass loss is concentrated near Pine Island and Thwaites glaciers, it has also increased along the coast further towards the Ross ice shelf.

  7. Using a mass balance to determine the potency loss during the production of a pharmaceutical blend.

    Science.gov (United States)

    Mackaplow, Michael B

    2010-09-01

    The manufacture of a blend containing the active pharmaceutical ingredient (API) and inert excipients is a precursor for the production of most pharmaceutical capsules and tablets. However, if there is a net water gain or preferential loss of API during production, the potency of the final drug product may be less than the target value. We use a mass balance to predict the mean potency loss during the production of a blend via wet granulation and fluidized bed drying. The result is an explicit analytical equation for the change in blend potency a function of net water gain, solids losses (both regular and high-potency), and the fraction of excipients added extragranularly. This model predicts that each 1% gain in moisture content (as determined by a loss on drying test) will decrease the API concentration of the final blend at least 1% LC. The effect of pre-blend solid losses increases with their degree of superpotency. This work supports Quality by Design by providing a rational method to set the process design space to minimize blend potency losses. When an overage is necessary, the model can help justify it by providing a quantitative, first-principles understanding of the sources of potency loss. The analysis is applicable to other manufacturing processes where the primary sources of potency loss are net water gain and/or mass losses.

  8. Recurrent variants in OTOF are significant contributors to prelingual nonsydromic hearing loss in Saudi patients

    Science.gov (United States)

    Almontashiri, Naif A M; Alswaid, Abdulrahman; Oza, Andrea; Al-Mazrou, Khalid A; Elrehim, Omnia; Tayoun, Ahmad Abou; Rehm, Heidi L; Amr, Sami S

    2018-01-01

    Purpose Hearing loss is more prevalent in the Saudi Arabian population than in other populations; however, the full range of genetic etiologies in this population is unknown. We report the genetic findings from 33 Saudi hearing-loss probands of tribal ancestry, with predominantly prelingual severe to profound hearing loss. Methods Testing was performed over the course of 2012–2016, and involved initial GJB2 sequence and GJB6-D13S1830 deletion screening, with negative cases being reflexed to a next-generation sequencing panel with 70, 71, or 87 hearing-loss genes. Results A “positive” result was reached in 63% of probands, with two recurrent OTOF variants (p.Glu57* and p.Arg1792His) accountable for a third of all “positive” cases. The next most common cause was pathogenic variants in MYO7A and SLC26A4, each responsible for three “positive” cases. Interestingly, only one “positive” diagnosis had a DFNB1-related cause, due to a homozygous GJB6-D13S1830 deletion, and no sequence variants in GJB2 were detected. Conclusion Our findings implicate OTOF as a potential major contributor to hearing loss in the Saudi population, while highlighting the low contribution of GJB2, thus offering important considerations for clinical testing strategies for Saudi patients. Further screening of Saudi patients is needed to characterize the genetic spectrum in this population. PMID:29048421

  9. Growth hormone mitigates loss of periosteal bone formation and muscle mass in disuse osteopenic rats

    DEFF Research Database (Denmark)

    Grubbe, M-C; Thomsen, Jesper Skovhus; Nyengaard, J R

    2014-01-01

    Growth hormone (GH) is a potent anabolic agent capable of increasing both bone and muscle mass. The aim was to investigate whether GH could counteract disuse-induced loss of bone and muscle mass in a rat model. Paralysis was induced by injecting 4 IU Botox (BTX) into the muscles of the right hind...... of periosteal BFR/BS (2-fold increase vs. BTX, Pmuscle mass (+29% vs. BTX, Pmuscle CSA (+11%, P=0.064). In conclusion, GH mitigates disuse......BMD, -13%, Pmuscle mass (-69%, Pmuscle cell cross sectional area (CSA) (-73%, P

  10. VizieR Online Data Catalog: Adiabatic mass loss in binary stars. II. (Ge+, 2015)

    Science.gov (United States)

    Ge, H.; Webbink, R. F.; Chen, X.; Han, Z.

    2016-02-01

    In the limit of extremely rapid mass transfer, the response of a donor star in an interacting binary becomes asymptotically one of adiabatic expansion. We survey here adiabatic mass loss from Population I stars (Z=0.02) of mass 0.10M⊙-100M⊙ from the zero-age main sequence to the base of the giant branch, or to central hydrogen exhaustion for lower main sequence stars. The logarithmic derivatives of radius with respect to mass along adiabatic mass-loss sequences translate into critical mass ratios for runaway (dynamical timescale) mass transfer, evaluated here under the assumption of conservative mass transfer. For intermediate- and high-mass stars, dynamical mass transfer is preceded by an extended phase of thermal timescale mass transfer as the star is stripped of most of its envelope mass. The critical mass ratio qad (throughout this paper, we follow the convention of defining the binary mass ratio as q{equiv}Mdonor/Maccretor) above which this delayed dynamical instability occurs increases with advancing evolutionary age of the donor star, by ever-increasing factors for more massive donors. Most intermediate- or high-mass binaries with nondegenerate accretors probably evolve into contact before manifesting this instability. As they approach the base of the giant branch, however, and begin developing a convective envelope, qad plummets dramatically among intermediate-mass stars, to values of order unity, and a prompt dynamical instability occurs. Among low-mass stars, the prompt instability prevails throughout main sequence evolution, with qad declining with decreasing mass, and asymptotically approaching qad=2/3, appropriate to a classical isentropic n=3/2 polytrope. Our calculated qad values agree well with the behavior of time-dependent models by Chen & Han (2003MNRAS.341..662C) of intermediate-mass stars initiating mass transfer in the Hertzsprung gap. Application of our results to cataclysmic variables, as systems that must be stable against rapid mass

  11. Significant reduction in blood loss in patients undergoing minimal extracorporeal circulation

    NARCIS (Netherlands)

    Gerritsen, W. B.; van Boven, W. J.; Smelt, M.; Morshuis, W. J.; van Dongen, H. P.; Haas, F. J.; Aarts, L. P.

    2006-01-01

    Several recent studies have shown differences in blood loss and allogeneic transfusion requirements between on-pump and off-pump coronary artery bypass grafting (CABG). Recently a new concept, the mini-extracorporeal circulation, was introduced to minimize the side effects of extracorporeal

  12. Significant or negligible sediment and nutrient losses after fire? Pre- and post-fire comparisons

    Science.gov (United States)

    Shakesby, R. A.; Ferreira, A. J. D.; Ferreira, C. S. S.; Stoof, C. R.; Urbanek, E.; Walsh, R. P. D.

    2009-04-01

    Prescribed fire (or a controlled burn) is a management tool used in wildfire-prone areas to reduce the fuel load of living and dead biomass, while attempting to keep disturbance of the ground surface and soil to a minimum. We know that wildfire, particularly of moderate or extreme severity, can cause important changes to the chemical and physical properties of soil, typically leading to a reduction in aggregate stability, surface roughness and water storage capacity, and an increase in overland flow. It has also been shown that wildfire disturbance can cause major loss of soil, particularly at plot and hillslope scales. There is less information on soil losses at catchment scales, but it is known that losses particularly of organic-rich fine sediment and nutrients can undergo hillslope to channel transfer, where they can affect water quality. Far less research has been carried out into the effects of prescribed fire on soil and nutrient losses at all scales, but particularly at catchment scales. This paper considers the impact of an experimental fire (equivalent to a severe prescribed fire) on soil and nutrient losses. These losses have been monitored at a range of scales (small rainfall simulation plots, long-term erosion plot, erosion plot, hillslope sediment traps (sediment fences) and catchment) before and after the fire in a 10-ha catchment near Góis, central Portugal, which forms part of the 5-year DESIRE research programme concerning desertification and its mitigation at a range of study sites worldwide. The catchment has steep slopes covered mainly with scrub vegetation ranging from c. 0.15 to 2m in height. The soil is thin, stony and highly water repellent. Long-term pre-burn erosion rates are known from a c. 10-year record of soil losses from a small erosion plot (8 x 2m in size) and sediment accumulation in the weir pool of a subcatchment gauging station. Rainfall simulations carried out under dry and wet antecedent conditions before and after the fire

  13. Effects of main-sequence mass loss on the turnoff ages of globular clusters

    International Nuclear Information System (INIS)

    Guzik, J.A.

    1989-01-01

    Willson, Bowen, and Struck-Marcell have proposed that globular cluster main-sequence turnoff ages can be reconciled with the lower ages of the Galaxy and universe deduced from other methods by incorporating an epoch of early main-sequence mass-loss by stars of spectral types A through early-F. The proposed mass loss is pulsation-driven, and facilitated by rapid rotation. This paper presents stellar evolution calculations of Pop. II (Z = 0.001) mass-losing stars of initial mass 0.8 to 1.6 M circle dot , with exponentially-decreasing mass loss rates of e-folding times 0.5 to 2.0 Gyr, evolving to a final mass of 0.7 M circle dot . The calculations indicate that a globular cluster with apparent turnoff age 18 Gyr could have an actual age as low as ∼12 Gyr. Observational implications that may help to verify the hypothesis, e.g. low C/N abundance ratios among red giants following first dredge-up, blue stragglers, red giant deficiencies, and signatures in cluster mass/luminosity functions, are also discussed.25 refs., 4 figs., 3 tabs

  14. Loss of lean body mass affects low bone mineral density in patients with rheumatoid arthritis - results from the TOMORROW study.

    Science.gov (United States)

    Okano, Tadashi; Inui, Kentaro; Tada, Masahiro; Sugioka, Yuko; Mamoto, Kenji; Wakitani, Shigeyuki; Koike, Tatsuya; Nakamura, Hiroaki

    2017-11-01

    Osteoporosis is one of the complications for patients with rheumatoid arthritis (RA). Rheumatoid cachexia, the loss of lean body mass, is another. However, the relationship between decreased lean body mass and reduced bone mineral density (BMD) in patients with RA has not been well studied. This study included 413 participants, comprising 208 patients with RA and 205 age- and sex-matched healthy volunteers. Clinical data, BMD, bone metabolic markers (BMM) and body composition, such as lean body mass and percent fat, were collected. Risk factors for osteoporosis in patients with RA including the relationship BMD and body composition were analyzed. Patients with RA showed low BMD and high BMM compared with controls. Moreover, lean body mass was lower and percent fat was higher in patients with RA. Lean body mass correlated positively and percent fat negatively with BMD. Lean body mass was a positive and disease duration was a negative independent factor for BMD in multivariate statistical analysis. BMD and lean body mass were significantly lower in patients with RA compared to healthy controls. Lean body mass correlated positively with BMD and decreased lean body mass and disease duration affected low BMD in patients with RA. [UMIN Clinical Trials Registry, http://www.umin.ac.jp/ctr/ , UMIN000003876].

  15. Effect of mass loss on the driving of g-modes in B supergiant stars

    Energy Technology Data Exchange (ETDEWEB)

    Godart, Melanie; Noels, Arlette [Institut d' Astrophysique et de Geophysique, Liege (Belgium); Dupret, Marc-Antoine [Observatoire de Paris-Meudon, LESIA (France)], E-mail: Helanie.Godart@ulg.ac.be, E-mail: Arlette.Noels@ulg.ac.be, E-mail: ma.dupret@obspm.fr

    2008-10-15

    MOST has detected p and g-modes in the B supergiant star HD163899. Saio et al. (2006) have explained the driving of g-modes in a post main sequence star by the presence of a convective shell which prevents some modes from entering the damping radiative core. We show that this scenario depends on the evolution of the star, with or without mass loss. If the mass loss rate is high enough, the convective shell disappears and all the g-modes are stable.

  16. Effect of mass loss on the driving of g-modes in B supergiant stars

    International Nuclear Information System (INIS)

    Godart, Melanie; Noels, Arlette; Dupret, Marc-Antoine

    2008-01-01

    MOST has detected p and g-modes in the B supergiant star HD163899. Saio et al. (2006) have explained the driving of g-modes in a post main sequence star by the presence of a convective shell which prevents some modes from entering the damping radiative core. We show that this scenario depends on the evolution of the star, with or without mass loss. If the mass loss rate is high enough, the convective shell disappears and all the g-modes are stable.

  17. Exploring the effect of East Antarctic ice mass loss on GIA-induced horizontal bedrock motions

    Science.gov (United States)

    Konfal, S. A.; Whitehouse, P. L.; Hermans, T.; van der Wal, W.; Wilson, T. J.; Bevis, M. G.; Kendrick, E. C.; Dalziel, I.; Smalley, R., Jr.

    2017-12-01

    Ice history inputs used in Antarctic models of GIA include major centers of ice mass loss in West Antarctica. In the Transantarctic Mountains (TAM) region spanning the boundary between East and West Antarctica, horizontal crustal motions derived from GPS observations from the Antarctic Network (ANET) component of the Polar Earth Observing Network (POLENET) are towards these West Antarctic ice mass centers, opposite to the pattern of radial crustal motion expected in an unloading scenario. We investigate alternative ice history and earth structure inputs to GIA models in an attempt to reproduce observed crustal motions in the region. The W12 ice history model is altered to create scenarios including ice unloading in the Wilkes Subglacial Basin based on available glaciological records. These altered ice history models, along with the unmodified W12 ice history model, are coupled with 60 radially varying (1D) earth model combinations, including approximations of optimal earth profiles identified in published GIA models. The resulting model-predicted motions utilizing both the modified and unmodified ice history models fit ANET GPS-derived crustal motions in the northern TAM region for a suite of earth model combinations. Further south, where the influence of simulated Wilkes unloading is weakest and West Antarctic unloading is strongest, observed and predicted motions do not agree. The influence of simulated Wilkes ice unloading coupled with laterally heterogeneous earth models is also investigated. The resulting model-predicted motions do not differ significantly between the original W12 and W12 with simulated Wilkes unloading ice histories.

  18. Mass loss of the Greenland Ice Sheet since the Little Ice Age, implications on sea level

    DEFF Research Database (Denmark)

    Kjeldsen, K. K.; Bjork, A. A.; Khan, Shfaqat Abbas

    The impact of mass loss from the Greenland Ice Sheet (GrIS) on 20th Century sea level rise (SLR) has long been subject to intense discussions. While globally distributed tide gauges suggest a global mean SLR of 15-20 cm, quantifying the separate components is of great concern - in particular...... for modeling sea level projections into the 21st Century. Estimates of the past GrIS contribution to SLR have been derived using a number of different approaches, e.g. surface mass balance (SMB) calculations combined with estimates of ice discharge found by in correlating SMB anomalies and calving rates. Here......-2010, NASA's Ice, Cloud, and land Elevation Satellite (ICESat) from 2003-2009, and NASA's Land, Vegetation, and Ice Sensor (LVIS) from 2010, to estimate mass loss throughout the 20th and early 21st Century. We present mass balance estimates of the GrIS since retreat commence from the maximum extent...

  19. Spread of ice mass loss into northwest Greenland observed by GRACE and GPS

    DEFF Research Database (Denmark)

    Khan, Shfaqat Abbas; Wahr, John; Bevis, Michael

    2010-01-01

    Global Positioning System (GPS) measurements from three long-term sites on bedrock adjacent to the ice sheet. The GRACE results provide a direct measure of mass loss averaged over scales of a few hundred km. The GPS data are used to monitor crustal uplift caused by ice mass loss close to the sites....... The GRACE results can be used to predict crustal uplift, which can be compared with the GPS data. In addition to showing that the northwest ice sheet margin is now losing mass, the uplift results from both the GPS measurements and the GRACE predictions show rapid acceleration in southeast Greenland in late...... 2003, followed by a moderate deceleration in 2006. Because that latter deceleration is weak, southeast Greenland still appears to be losing ice mass at a much higher rate than it was prior to fall 2003. In a more general sense, the analysis described here demonstrates that GPS uplift measurements can...

  20. Investigation of Electron Beam Induced Mass Loss of Embedding Media in the Low Voltage STEM

    Czech Academy of Sciences Publication Activity Database

    Novotná, V.; Hrubanová, Kamila; Nebesářová, J.; Krzyžánek, Vladislav

    2014-01-01

    Roč. 20, S3 (2014), s. 1270-1271 ISSN 1431-9276 R&D Projects: GA MŠk EE.2.3.20.0103; GA MŠk(CZ) LO1212; GA ČR(CZ) GA14-20012S; GA TA ČR TE01020118 Institutional support: RVO:68081731 Keywords : mass loss * mass -thickness measurement * low voltage STEM Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 1.877, year: 2014

  1. Elastic uplift in southeast Greenland due to rapid ice mass loss

    DEFF Research Database (Denmark)

    Khan, Shfaqat Abbas; Van dam, Tonie; Hamilton, Gordon S.

    2007-01-01

    The rapid unloading of ice from the southeastern sector of the Greenland ice sheet between 2001 and 2006 caused an elastic uplift of 35 mm at a GPS site in Kulusuk. Most of the uplift results from ice dynamic-induced volume losses on two nearby outlet glaciers. Volume loss from Helheim Glacier...... between 62N and 66N. Citation: Khan, S. A., J. Wahr, L. A. Stearns, G. S. Hamilton, T. van Dam, K. M. Larson, and O. Francis (2007), Elastic uplift in southeast Greenland due to rapid ice mass loss....

  2. Relationship between oxidative stress and muscle mass loss in early postmenopause: an exploratory study.

    Science.gov (United States)

    Zacarías-Flores, Mariano; Sánchez-Rodríguez, Martha A; García-Anaya, Oswaldo Daniel; Correa-Muñoz, Elsa; Mendoza-Núñez, Víctor Manuel

    2018-04-09

    Endocrine changes due to menopause have been associated to oxidative stress and muscle mass loss. The study objective was to determine the relationship between both variables in early postmenopause. An exploratory, cross-sectional study was conducted in 107 pre- and postmenopausal women (aged 40-57 years). Levels of serum lipid peroxides and uric acid and enzymes superoxide dismutase and glutathione peroxidase, as well as total plasma antioxidant capacity were measured as oxidative stress markers. Muscle mass using bioelectrical impedance and muscle strength using dynamometry were also measured. Muscle mass, skeletal muscle index, fat-free mass, and body mass index were calculated. More than 90% of participants were diagnosed with overweight or obesity. Postmenopausal women had lower values of muscle mass and strength markers, with a negative correlation between lipid peroxide level and skeletal muscle index (r= -0.326, p<.05), and a positive correlation between uric acid and skeletal muscle index (r=0.295, p<.05). A multivariate model including oxidative stress markers, age, and waist circumference showed lipid peroxide level to be the main contributor to explain the decrease in skeletal muscle mass in postmenopause, since for every 0.1μmol/l increase in lipid peroxide level, skeletal muscle index decreases by 3.03 units. Our findings suggest an association between increased oxidative stress and muscle mass loss in early postmenopause. Copyright © 2018 SEEN y SED. Publicado por Elsevier España, S.L.U. All rights reserved.

  3. THE MASS-LOSS RETURN FROM EVOLVED STARS TO THE LARGE MAGELLANIC CLOUD. VI. LUMINOSITIES AND MASS-LOSS RATES ON POPULATION SCALES

    International Nuclear Information System (INIS)

    Riebel, D.; Meixner, M.; Srinivasan, S.; Sargent, B.

    2012-01-01

    We present results from the first application of the Grid of Red Supergiant and Asymptotic Giant Branch ModelS (GRAMS) model grid to the entire evolved stellar population of the Large Magellanic Cloud (LMC). GRAMS is a pre-computed grid of 80,843 radiative transfer models of evolved stars and circumstellar dust shells composed of either silicate or carbonaceous dust. We fit GRAMS models to ∼30,000 asymptotic giant branch (AGB) and red supergiant (RSG) stars in the LMC, using 12 bands of photometry from the optical to the mid-infrared. Our published data set consists of thousands of evolved stars with individually determined evolutionary parameters such as luminosity and mass-loss rate. The GRAMS grid has a greater than 80% accuracy rate discriminating between oxygen- and carbon-rich chemistry. The global dust injection rate to the interstellar medium (ISM) of the LMC from RSGs and AGB stars is on the order of 2.1 × 10 –5 M ☉ yr –1 , equivalent to a total mass injection rate (including the gas) into the ISM of ∼6 × 10 –3 M ☉ yr –1 . Carbon stars inject two and a half times as much dust into the ISM as do O-rich AGB stars, but the same amount of mass. We determine a bolometric correction factor for C-rich AGB stars in the K s band as a function of J – K s color, BC K s = -0.40(J-K s ) 2 + 1.83(J-K s ) + 1.29. We determine several IR color proxies for the dust mass-loss rate (M-dot d ) from C-rich AGB stars, such as log M-dot d = (-18.90/((K s -[8.0])+3.37) - 5.93. We find that a larger fraction of AGB stars exhibiting the 'long-secondary period' phenomenon are more O-rich than stars dominated by radial pulsations, and AGB stars without detectable mass loss do not appear on either the first-overtone or fundamental-mode pulsation sequences.

  4. HRR Upgrade to mass loss calorimeter and modified Schlyter test for FR Wood

    Science.gov (United States)

    Mark A. Dietenberger; Charles R. Boardman

    2013-01-01

    Enhanced Heat Release Rate (HRR) methodology has been extended to the Mass Loss Calorimeter (MLC) and the Modified Schlyter flame spread test to evaluate fire retardant effectiveness used on wood based materials. Modifications to MLC include installation of thermopile on the chimney walls to correct systematic errors to the sensible HRR calculations to account for...

  5. Observations of mass loss from OB and Wolf-Rayet stars

    International Nuclear Information System (INIS)

    Barlow, M.J.

    1982-01-01

    In this review, three observationally accessible parameters of the winds of OB and Wolf-Rayet stars are discussed: (1) Terminal velocities, (2) Velocity laws, (3) Mass loss rates. In addition, some discussion of the ionisation structure of the winds is included. In general, only the most recent results for OB stars are mentioned. (Auth.)

  6. Mid-Pleistocene climate transition drives net mass loss from rapidly uplifting St. Elias mountains, Alaska

    Digital Repository Service at National Institute of Oceanography (India)

    Gulick, S.P.S.; Jaeger, J.M.; Mix, A.C.; Asahi, H.; Bahlburg, H.; Belanger, C.L.; Berbel, G.B.B.; Childress, L.; Cowan, E.; Drab, L.; Forwick, M.; Fukumura, A.; Ge, S.; Gupta, S.M.; Kioka, A.; Konno, S.; LeVay, L.J.; Marz, C.; Matsuzaki, K.M.; McClymont, E.L.; Moy, C.; Muller, J.; Nakamura, A.; Ojima, T.; Ribeiro, F.R.; Ridgway, K.D.; Romero, O.E.; Slagle, A.L.; Stoner, J.S.; St-Onge, G.; Suto, I.; Walczak, M.D.; Worthington, L.L.; Bailey, I.; Enkelmann, E.; Reece, R.; Swartz, J.M.

    the onset of quasi-periodic (~100-ky) glacial cycles in the mid-Pleistocene climate transition (1.2–0.7 Ma). Since then, erosion and transport of material out of the orogen has outpaced tectonic influx by 50–80%. Such a rapid net mass loss explains apparent...

  7. AGB mass-loss variations: What can we learn from (sub)millimetre observations?

    NARCIS (Netherlands)

    Dehaes, S.; Groenewegen, M.A.T.; Decin, L.; Hony, S.; Raskin, G.; Blommaert, J.A.D.L.

    2008-01-01

    It is generally acknowledged that the mass loss of Asymptotic Giant Branch (AGB) stars undergoes variations on different time scales. We address here the question of the influence of these variations on the spectral energy distribution (SED) of these sources. We therefore constructed models for the

  8. Mass loss of evolved massive stars: the circumstellar environment at high angular resolution

    International Nuclear Information System (INIS)

    Montarges, Miguel

    2014-01-01

    Mass loss of evolved stars is still largely mysterious, despite its importance as the main evolution engine for the chemical composition of the interstellar medium. For red supergiants (RSG), the triggering of the outflow and the mechanism of dust condensation remain unknown. Concerning red giant stars, we still do not know how their mass loss is able to form a bipolar planetary nebula. During my PhD thesis, I observed evolved stars with high angular resolution techniques. They allowed us to study the surface and the close environment of these stars, from where mass loss originates. With near-infrared interferometric observations, I characterized the water vapor and carbon monoxide envelope of the nearby RSG Betelgeuse. I also monitored a hot spot on its surface and analyzed the structure of its convection, as well as that of Antares (another very nearby supergiant) thanks to radiative hydrodynamical simulations. Diffraction-limited imaging techniques (near-infrared adaptive optics, ultraviolet space telescope) allowed me to observe the evolution of inhomogeneities in the circumstellar envelope of Betelgeuse and to discover a circumstellar disk around L2 Puppis, an asymptotic giant branch star. These multi-scale and multi-wavelength observations obtained at several epochs allowed us to monitor the evolution of the structures and to derive information on the dynamics of the stellar environment. With a wider stellar sample expected in the next few years, this observing program will allow a better understanding of the mass loss of evolved stars. (author)

  9. Postoperative loss of skeletal muscle mass, complications and quality of life in patients undergoing cardiac surgery

    NARCIS (Netherlands)

    van Venrooij, Lenny M. W.; Verberne, Hein J.; de Vos, Rien; Borgmeijer-Hoelen, Mieke M. M. J.; van Leeuwen, Paul A. M.; de Mol, Bas A. J. M.

    2012-01-01

    Objective: The objective of this study was to describe postoperative undernutrition in terms of postoperative losses of appendicular skeletal muscle mass (ASMM) with respect to complications, quality of life, readmission, and 1-y mortality after cardiac surgery. Methods: Patients undergoing cardiac

  10. The influence of loss and gain of body mass on ovarian activity in ...

    African Journals Online (AJOL)

    Ovarian activity was studied in 36 dry, Bos taurus cows fed to achieve different rates of body mass loss and gain in a 2 x 2 factorial experiment. Cows were fed hay to supply either 70% (Treatments 1, 2) or 40% (Treatments. 3,4) of their ME requirements for maintenance until they became anoestrus. Following a 90-day ...

  11. Growth hormone mitigates loss of periosteal bone formation and muscle mass in disuse osteopenic rats.

    Science.gov (United States)

    Grubbe, M-C; Thomsen, J S; Nyengaard, J R; Duruox, M; Brüel, A

    2014-12-01

    Growth hormone (GH) is a potent anabolic agent capable of increasing both bone and muscle mass. The aim was to investigate whether GH could counteract disuse-induced loss of bone and muscle mass in a rat model. Paralysis was induced by injecting 4 IU Botox (BTX) into the muscles of the right hind limb. Sixty female Wistar rats, 14 weeks old, were divided into the following groups: baseline, controls, BTX, BTX+GH, and GH. GH was given at a dosage of 5 mg/kg/d for 4 weeks. Compared with controls, BTX resulted in lower periosteal bone formation rate (BFR/BS,-79%, Pbone mineral density (aBMD, -13%, Pbone volume (BV/TV, -26%, Pbone strength (-12%, Pbone strength was found. In addition, GH partly prevented loss of muscle mass (+29% vs. BTX, P<0.001), and tended to prevent loss of muscle CSA (+11%, P=0.064). In conclusion, GH mitigates disuse-induced loss of periosteal BFR/BS at the mid-femur and rectus femoris muscle mass.

  12. Habitats at Risk. Global Warming and Species Loss in Globally Significant Terrestrial Ecosystems

    International Nuclear Information System (INIS)

    Malcolm, J.R.; Liu, Canran; Miller, L.B.; Allnutt, T.; Hansen, L.

    2002-02-01

    In this study, a suite of models of global climate and vegetation change is used to investigate three important global warming-induced threats to the terrestrial Global 200 ecoregions: (1) Invasions by new habitat types (and corresponding loss of original habitat types); (2) Local changes of habitat types; (3) High rates of required species migration. Seven climate models (general circulation models or GCMs) and two vegetation models (BIOME3 and MAPSS) were used to produce 14 impact scenarios under the climate associated with a doubling of atmospheric CO2 concentrations, which is expected to occur in less than 100 years. Previous analyses indicated that most of the variation among the impact scenarios was attributable to the particular vegetation model used, hence the authors provide results separately for the two models. The models do not provide information on biodiversity per se, but instead simulate current and future potential distributions of major vegetation types (biomes) such as tundra and broadleaf tropical rain forest

  13. Mass loss by stars at the stage of the asymptotic giant branch

    International Nuclear Information System (INIS)

    Frantsman, Y.L.

    1986-01-01

    For a given initial stellar mass function, star formation function, and initial chemical composition, distributions have been constructed for stars of the asymptotic giant branch by luminosity, and for white dwarfs by mass, by calculating the approximate evolution of a large number of stars. Variants are calculated with different assumptions about the mass loss in the asymptotic branch. Theory can be reconciled with observation only if it is assumed that at this stage there is also a still large mass loss in addition to the stellar wind and the ejection of a planetary nebula shell. This provides the explanation for the absence in the Magellanic clouds of carbon stars with M /sub bol/ 1.0M /sub ./. The degenerate carbon-oxygen nuclei of stars evolving along the asymptotic giant branch cannot attain the Chandrasekhar limit on account of the great mass loss by the stars. The luminosity of stars of the asymptotic giant branch in the globular clusters of the Magellanic Clouds is a good indicator of the age of the clusters

  14. Evidence for mass loss at moderate to high velocity in Be stars

    Science.gov (United States)

    Snow, T. P., Jr.; Marlborough, J. M.

    1976-01-01

    Ultraviolet spectra of intermediate resolution have been obtained with Copernicus for 12 objects classified as Be or shell stars and for 19 additional early B dwarfs. Some of these spectra show marked asymmetries in certain resonance lines, especially the Si IV doublet at 1400 A, indicating the presence in some cases of outflowing material with maximum velocities of nearly 1000 km/s. Direct evidence for mass loss at these velocities is seen for the first time in dwarf stars as late as B1.5; the only objects later than B0.5 which show this effect are Be or shell stars. Among the stars considered, there is a correlation between the presence of mass-loss effects and projected rotational velocity, suggesting that the ultraviolet flux from B1-B2 dwarfs is sufficient to drive high-velocity stellar winds only if rotational effects reduce the effective gravity near the equator. The mass-loss rate for one of the most active Be stars, 59 Cyg, is crudely estimated to be one billionth or one ten-billionth of a solar mass per year. The data suggest that the extended atmospheres associated with Be-star phenomena may be formed by mass ejection.

  15. Bone Mass and Strength are Significantly Improved in Mice Overexpressing Human WNT16 in Osteocytes.

    Science.gov (United States)

    Alam, Imranul; Reilly, Austin M; Alkhouli, Mohammed; Gerard-O'Riley, Rita L; Kasipathi, Charishma; Oakes, Dana K; Wright, Weston B; Acton, Dena; McQueen, Amie K; Patel, Bhavmik; Lim, Kyung-Eun; Robling, Alexander G; Econs, Michael J

    2017-04-01

    Recently, we demonstrated that osteoblast-specific overexpression of human WNT16 increased both cortical and trabecular bone mass and structure in mice. To further identify the cell-specific role of Wnt16 in bone homeostasis, we created transgenic (TG) mice overexpressing human WNT16 in osteocytes using Dmp1 promoter (Dmp1-hWNT16 TG) on C57BL/6 (B6) background. We analyzed bone phenotypes and serum bone biomarkers, performed gene expression analysis and measured dynamic bone histomorphometry in Dmp1-hWNT16 TG and wild-type (WT) mice. Compared to WT mice, Dmp1-hWNT16 TG mice exhibited significantly higher whole-body, spine and femoral aBMD, BMC and trabecular (BV/TV, Tb.N, and Tb.Th) and cortical (bone area and thickness) parameters in both male and female at 12 weeks of age. Femur stiffness and ultimate force were also significantly improved in the Dmp1-hWNT16 TG female mice, compared to sex-matched WT littermates. In addition, female Dmp1-hWNT16 TG mice displayed significantly higher MS/BS, MAR and BFR/BS compared to the WT mice. Gene expression analysis demonstrated significantly higher mRNA level of Alp in both male and female Dmp1-hWNT16 TG mice and significantly higher levels of Osteocalcin, Opg and Rankl in the male Dmp1-hWNT16 TG mice in bone tissue compared to sex-matched WT mice. These results indicate that WNT16 plays a critical role for acquisition of both cortical and trabecular bone mass and strength. Strategies designed to use WNT16 as a target for therapeutic interventions will be valuable to treat osteoporosis and other low bone mass conditions.

  16. The Colorado Ultraviolet Transit Experiment (CUTE): Observing Mass Loss on Short-Period Exoplanets

    Science.gov (United States)

    Egan, Arika; Fleming, Brian; France, Kevin

    2018-06-01

    The Colorado Ultraviolet Transit Experiment (CUTE) is an NUV spectrograph packaged into a 6U CubeSat, designed to characterize the interaction between exoplanetary atmospheres and their host stars. CUTE will conduct a transit spectroscopy survey, gathering data over multiple transits on more than 12 short-period exoplanets with a range of masses and radii. The instrument will characterize the spectral properties of the transit light curves to atomic and molecular absorption features predicted to exist in the upper atmospheres of these planets, including Mg I, Mg II, Fe II, and OH. The shape and evolution of these spectral light curves will be used to quantify mass loss rates, the stellar drives of that mass loss, and the possible existence of exoplanetary magnetic fiends. This poster presents the science motivation for CUTE, planned observation and data analysis methods, and expected results.

  17. Photometry of SN 2002ic and implications for the progenitor mass-loss history

    International Nuclear Information System (INIS)

    Wood-Vasey, W.M.; Wang, L.; Aldering, G.

    2004-01-01

    We present new pre-maximum and late-time optical photometry of the Type Ia/IIn supernova 2002ic. These observations are combined with the published V-band magnitudes of Hamuy et al. (2003) and the VLT spectrophotometry of Wang et al. (2004) to construct the most extensive light curve to date of this unusual supernova. The observed flux at late time is significantly higher relative to the flux at maximum than that of any other observed Type Ia supernova and continues to fade very slowly a year after explosion. Our analysis of the light curve suggests that a non-Type Ia supernova component becomes prominent ∼20 days after explosion. Modeling of the non-Type Ia supernova component as heating from the shock interaction of the supernova ejecta with pre-existing circumstellar material suggests the presence of a ∼1.7 x 1015 cm gap or trough between the progenitor system and the surrounding circumstellar material. This gap could be due to significantly lower mass-loss ∼15 (nu omega /10 km/s) -1 years prior to explosion or evacuation of the circumstellar material by a low-density fast wind. The latter is consistent with observed properties of proto-planetary nebulae and with models of white-dwarf + asymptotic giant branch star progenitor systems with the asymptotic giant branch star in the proto-planetary nebula phase

  18. Sustained mass loss of the northeast Greenland ice sheet triggered by regional warming

    DEFF Research Database (Denmark)

    Khan, Shfaqat Abbas; Kjaer, Kurt H.; Bevis, Michael

    2014-01-01

    The Greenland ice sheet has been one of the largest contributors to global sea-level rise over the past 20 years, accounting for 0.5 mm yr(-1) of a total of 3.2 mm yr(-1). A significant portion of this contribution is associated with the speed-up of an increased number of glaciers in southeast...... and northwest Greenland. Here, we show that the northeast Greenland ice stream, which extends more than 600 km into the interior of the ice sheet, is now undergoing sustained dynamic thinning, linked to regional warming, after more than a quarter of a century of stability. This sector of the Greenland ice sheet...... is of particular interest, because the drainage basin area covers 16% of the ice sheet (twice that of Jakobshavn Isbrae) and numerical model predictions suggest no significant mass loss for this sector, leading to an under-estimation of future global sea-level rise. The geometry of the bedrock and monotonic trend...

  19. Explaining individual variation in patterns of mass loss in breeding birds

    Directory of Open Access Journals (Sweden)

    Cuthill Innes C

    2006-05-01

    Full Text Available Abstract Background Studies of birds have a disproportionate representation in the literature on life-history evolution, because of the (apparent ease with which the costs and benefits can be quantified and manipulated. During reproduction, birds frequently show a highly conserved pattern of mass change and changes in mass loss during breeding have been widely considered to be a valid short-term measure of the costs of reproduction. Experimental manipulations of the breeding attempts of birds usually argue that the presence of a response shows that a cost of reproduction exists, but there is little consensus as to how the size of these costs can be measured. Results We model this mass loss by considering how a parent can maximise its lifetime reproductive success, using a theoretical framework that is particularly suited to modelling parental care in altricial birds. If lifetime reproductive success is taken to be the sum of a parent's current and future reproductive success, we show that the exact forms of these components will influence the optimal amount of mass a parent should lose. In particular, we demonstrate that the shape of the relationship between parental investment and chick survival will lead to differing degrees of investment between parents of different initial qualities: parents with initially high levels of energy reserves could conceivably invested a lesser, similar or greater amount of resources than parents with initially low reserves, and these initially 'heavy' parents could potentially end up being lighter than the initially 'lighter' individuals. Conclusion We argue that it is difficult to make predictions about the dependence of a parent's final mass on its initial mass, and therefore mass loss should only be used as a short-term measure of the costs of reproduction with caution. The model demonstrates that we require a better understanding of the relationship between mass loss and both current and future reproductive

  20. DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice

    DEFF Research Database (Denmark)

    Abdallah, Basem M; Ditzel, Nicholas; Mahmood, Amer

    2011-01-01

    . In a number of in vitro culture systems, Dlk1 stimulated osteoclastogenesis indirectly through osteoblast-dependent increased production of proinflammatory bone-resorbing cytokines (eg, Il7, Tnfa, and Ccl3). We found that ovariectomy (ovx)-induced bone loss was associated with increased production of Dlk1...... in the bone marrow by activated T cells. Interestingly, Dlk1(-/-) mice were significantly protected from ovx-induced bone loss compared with wild-type mice. Thus we identified Dlk1 as a novel regulator of bone mass that functions to inhibit bone formation and to stimulate bone resorption. Increasing DLK1...... production by T cells under estrogen deficiency suggests its possible use as a therapeutic target for preventing postmenopausal bone loss....

  1. Mass loss from red giants - A simple evolutionary model for NGC 7027

    Science.gov (United States)

    Jura, M.

    1984-01-01

    NGC 7027 is a young planetary nebula with the remnants of a red giant circumstellar envelope surrounding the central, ionized region. By comparing the outer molecular envelope with the inner ionized material, it is argued that the mass loss rate has decreased by at least a factor of 3, and more probably by about a factor of 10, during the past 1000 years. From this result, it is argued that the luminosity of the central star has also decreased substantially during the same time, consistent with models for the rapid evolution of stars just after they evolve off the asymptotic giant branch. In this picture, the distance to NGC 7027 is less than 1300 pc. NGC 7027 was the last (and best) example of a star where apparently the momentum in the outflowing mass /M(dot)v/ is considerably greater than the momentum in the radiation field (L/c). With the above description of this object, the evidence is now strong that quite often the mass lost from late-type giants is ultimately driven to infinity by radiation pressure on grains. If M(dot)v is as large as L/c for asymptotic branch stars, then it is expected that the total amount of mass lost during this stage of evolution is of the same magnitude as the initial mass of the star, and therefore this mass loss can profoundly affect the star's ultimate fate.

  2. Prognostic significance of low skeletal muscle mass compared with protein-energy malnutrition in liver cirrhosis.

    Science.gov (United States)

    Nishikawa, Hiroki; Enomoto, Hirayuki; Ishii, Akio; Iwata, Yoshinori; Miyamoto, Yuho; Ishii, Noriko; Yuri, Yukihisa; Takata, Ryo; Hasegawa, Kunihiro; Nakano, Chikage; Nishimura, Takashi; Yoh, Kazunori; Aizawa, Nobuhiro; Sakai, Yoshiyuki; Ikeda, Naoto; Takashima, Tomoyuki; Iijima, Hiroko; Nishiguchi, Shuhei

    2017-09-01

    To investigate the impact of low skeletal muscle mass (LSMM) on survival as compared with protein-energy malnutrition (PEM) in patients with liver cirrhosis (LC). A total of 206 individuals with LC were analyzed. We retrospectively examined the impact of LSMM, as defined by psoas muscle mass at the third lumber on computed tomography, on survival as compared with PEM. In terms of comparison of the effects of LSMM and PEM on survival, we used time-dependent receiver operating characteristics (ROC) analysis. Our study cohort included 115 men and 91 women with a median age of 67 years. There were 140 patients with Child-Pugh A, 62 with Child-Pugh B, and 4 with Child-Pugh C. A total of 117 patients (56.8%) had LSMM and 52 patients (25.2%) had PEM. The proportion of PEM in patients with LSMM (31.62%, 37/117) was significantly higher than in patients without LSMM (16.85%, 15/89) (P = 0.0229). In the multivariate analysis for the entire cohort, the presence of hepatocellular carcinoma, lower body mass index, presence of LSMM, lower triglyceride value, poorer renal function, and higher des-γ-carboxy prothrombin value were found to be significant adverse predictors linked to overall survival, while presence of PEM tended to be significant. In the time-dependent ROC analysis, all area under the ROCs for survival in LSMM at each time point were higher than those in PEM except for Child-Pugh B patients. In this comparison of LSMM and PEM on clinical outcomes in LC patients, it was shown that LSMM may have stronger prognostic impact than PEM. © 2016 The Japan Society of Hepatology.

  3. Evidence for mass loss at moderate to high velocity in Be stars

    International Nuclear Information System (INIS)

    Snow, T.P. Jr.; Marlborough, J.M.

    1976-01-01

    Ultraviolet spectra of intermediate resolution have been obtained with Copernicus of 12 objects classified as Be or shell stars, and 19 additional early B dwarfs. Some of these spectra show marked asymmetries in certain resonance lines, especially the Si iv doublet at 1400 A, indicating the presence in some cases of outflowing material with maximum velocities of nearly 1000 km s -1 . Direct evidence for mass loss at these velocities is seen for the first time in dwarf stars as late as B1.5; the only objects later than B0.5 which show this effect are Be or shell stars. Among the stars considered there is a correlation between the presence of mass-loss effects and projected rotational velocity, suggesting that the ultraviolet flux from B1-B2 dwarfs is sufficient to drive high-velocity stellar winds only if rotation effects reduce the effective gravity near the equator. The mass loss rate for one of the most active Be stars, 59 Cyg, is crudely estimated to be 10 -10 --10 -9 M/sub sun/ yr -1 . The data are suggestive that the extended atmospheres associated with Be star phenomena may be formed by mass ejection

  4. Fast Winds and Mass Loss from Metal-Poor Field Giants

    Science.gov (United States)

    Dupree, A. K.; Smith, Graeme H.; Strader, Jay

    2009-11-01

    Echelle spectra of the infrared He I λ10830 line were obtained with NIRSPEC on the Keck 2 telescope for 41 metal-deficient field giant stars including those on the red giant branch (RGB), asymptotic giant branch (AGB), and red horizontal branch (RHB). The presence of this He I line is ubiquitous in stars with T effgsim 4500 K and MV fainter than -1.5, and reveals the dynamics of the atmosphere. The line strength increases with effective temperature for T effgsim 5300 K in RHB stars. In AGB and RGB stars, the line strength increases with luminosity. Fast outflows (gsim 60 km s-1) are detected from the majority of the stars and about 40% of the outflows have sufficient speed as to allow escape of material from the star as well as from a globular cluster. Outflow speeds and line strengths do not depend on metallicity for our sample ([Fe/H]= -0.7 to -3.0), suggesting the driving mechanism for these winds derives from magnetic and/or hydrodynamic processes. Gas outflows are present in every luminous giant, but are not detected in all stars of lower luminosity indicating possible variability. Mass loss rates ranging from ~3 × 10-10 to ~6 × 10-8 M sun yr-1 estimated from the Sobolev approximation for line formation represent values with evolutionary significance for red giants and RHB stars. We estimate that 0.2 M sun will be lost on the RGB, and the torque of this wind can account for observations of slowly rotating RHB stars in the field. About 0.1-0.2 M sun will be lost on the RHB itself. This first empirical determination of mass loss on the RHB may contribute to the appearance of extended horizontal branches in globular clusters. The spectra appear to resolve the problem of missing intracluster material in globular clusters. Opportunities exist for "wind smothering" of dwarf stars by winds from the evolved population, possibly leading to surface pollution in regions of high stellar density. Data presented herein were obtained at the W. M. Keck Observatory, which

  5. THE TRANSITION MASS-LOSS RATE: CALIBRATING THE ROLE OF LINE-DRIVEN WINDS IN MASSIVE STAR EVOLUTION

    Energy Technology Data Exchange (ETDEWEB)

    Vink, Jorick S.; Graefener, Goetz, E-mail: jsv@arm.ac.uk [Armagh Observatory, College Hill, BT61 9DG Armagh (United Kingdom)

    2012-06-01

    A debate has arisen regarding the importance of stationary versus eruptive mass loss for massive star evolution. The reason is that stellar winds have been found to be clumped, which results in the reduction of unclumped empirical mass-loss rates. Most stellar evolution models employ theoretical mass-loss rates which are already reduced by a moderate factor of {approx_equal}2-3 compared to non-corrected empirical rates. A key question is whether these reduced rates are of the correct order of magnitude, or if they should be reduced even further, which would mean that the alternative of eruptive mass loss becomes necessary. Here we introduce the transition mass-loss rate M-dot{sub trans} between O and Wolf-Rayet stars. Its novelty is that it is model independent. All that is required is postulating the spectroscopic transition point in a given data set, and determining the stellar luminosity, which is far less model dependent than the mass-loss rate. The transition mass-loss rate is subsequently used to calibrate stellar wind strength by its application to the Of/WNh stars in the Arches cluster. Good agreement is found with two alternative modeling/theoretical results, suggesting that the rates provided by current theoretical models are of the right order of magnitude in the {approx}50 M{sub Sun} mass range. Our results do not confirm the specific need for eruptive mass loss as luminous blue variables, and current stellar evolution modeling for Galactic massive stars seems sound. Mass loss through alternative mechanisms might still become necessary at lower masses, and/or metallicities, and the quantification of alternative mass loss is desirable.

  6. THE TRANSITION MASS-LOSS RATE: CALIBRATING THE ROLE OF LINE-DRIVEN WINDS IN MASSIVE STAR EVOLUTION

    International Nuclear Information System (INIS)

    Vink, Jorick S.; Gräfener, Götz

    2012-01-01

    A debate has arisen regarding the importance of stationary versus eruptive mass loss for massive star evolution. The reason is that stellar winds have been found to be clumped, which results in the reduction of unclumped empirical mass-loss rates. Most stellar evolution models employ theoretical mass-loss rates which are already reduced by a moderate factor of ≅2-3 compared to non-corrected empirical rates. A key question is whether these reduced rates are of the correct order of magnitude, or if they should be reduced even further, which would mean that the alternative of eruptive mass loss becomes necessary. Here we introduce the transition mass-loss rate M-dot trans between O and Wolf-Rayet stars. Its novelty is that it is model independent. All that is required is postulating the spectroscopic transition point in a given data set, and determining the stellar luminosity, which is far less model dependent than the mass-loss rate. The transition mass-loss rate is subsequently used to calibrate stellar wind strength by its application to the Of/WNh stars in the Arches cluster. Good agreement is found with two alternative modeling/theoretical results, suggesting that the rates provided by current theoretical models are of the right order of magnitude in the ∼50 M ☉ mass range. Our results do not confirm the specific need for eruptive mass loss as luminous blue variables, and current stellar evolution modeling for Galactic massive stars seems sound. Mass loss through alternative mechanisms might still become necessary at lower masses, and/or metallicities, and the quantification of alternative mass loss is desirable.

  7. Mass loss and asymmetries in the lines of Iota Coronae Borealis

    International Nuclear Information System (INIS)

    Kapp, A.H.

    1976-01-01

    Recent observations by Smith and Parsons of the Hg--Mn star iota CrB have revealed slight asymmetries in the absorption lines. While these asymmetries are near the limits of detection at the resolution used, their appearance in several lines indicates that they are real. Proposed explanations of this phenomenon are not completely satisfactory. In this Letter it will be shown that the asymmetries are consistent with an accelerating radial flow of material in the photosphere of this star. The velocity needed to reproduce the observed asymmetry corresponds to a mass loss rate of roughly 10 -7 M/sub solar mass/ yr -1

  8. Evolutionary calculations for planetary nebula nuclei with continuing mass loss and realistic starting conditions

    International Nuclear Information System (INIS)

    Faulkner, D.J.; Wood, P.R.

    1984-01-01

    Evolutionary calculations for nuclei of planetary nebulae are described. They were made using assumptions regarding mass of the NPN, phase in the He shell flash cycle at which the NPN leaves the AGB, and time variation of the mass loss rate. Comparison of the evolutionary tracks with the observational Harman-Seaton sequence indicates that some recently published NPN luminosities may be too low by a factor of three. Comparison of the calculated timescales with the observed properties of NPN and of white dwarfs provides marginal evidence for the PN ejection being initiated by the helium shell flash itself

  9. Loss of mass and performance in skeletal muscle tissue: a continuum model

    Directory of Open Access Journals (Sweden)

    Giantesio Giulia

    2018-02-01

    Full Text Available We present a continuum hyperelastic model which describes the mechanical response of a skeletal muscle tissue when its strength and mass are reduced by aging. Such a reduction is typical of a geriatric syndrome called sarcopenia. The passive behavior of the material is described by a hyperelastic, polyconvex, transversely isotropic strain energy function, and the activation of the muscle is modeled by the so called active strain approach. The loss of ability of activating of an elder muscle is then obtained by lowering of some percentage the active part of the stress, while the loss of mass is modeled through a multiplicative decomposition of the deformation gradient. The obtained stress-strain relations are graphically represented and discussed in order to study some of the effects of sarcopenia.

  10. Effect of mass loss on the chemical yields from massive stars

    Energy Technology Data Exchange (ETDEWEB)

    Chiosi, C; Caimmi, R [Padua Univ. (Italy). Istituto di Astronomia

    1979-01-01

    Recent results on the calculation of the chemical yields from massive stars, are rediscussed by taking into account the occurrence of mass loss by stellar wind during the core H- and He-burning phases. The new yields are found to be compatible with the observed distribution of chemical abundances in the solar system, except for He. The net enrichment of several elements over the galaxy's lifetime is found to be consistent with the current estimate of the star formation rate, if we adopt a two phase process of galaxy formation (halodisk). The relative He to heavy element enrichment rate ..delta..Y/..delta..Z turns out to agree with the observational value when mass loss by stellar wind is taken into account.

  11. Computational Modelling of the Structural Integrity following Mass-Loss in Polymeric Charred Cellular Solids

    OpenAIRE

    J. P. M. Whitty; J. Francis; J. Howe; B. Henderson

    2014-01-01

    A novel computational technique is presented for embedding mass-loss due to burning into the ANSYS finite element modelling code. The approaches employ a range of computational modelling methods in order to provide more complete theoretical treatment of thermoelasticity absent from the literature for over six decades. Techniques are employed to evaluate structural integrity (namely, elastic moduli, Poisson’s ratios, and compressive brittle strength) of honeycomb systems known to approximate t...

  12. Model atmospheres with periodic shocks. [pulsations and mass loss in variable stars

    Science.gov (United States)

    Bowen, G. H.

    1989-01-01

    The pulsation of a long-period variable star generates shock waves which dramatically affect the structure of the star's atmosphere and produce conditions that lead to rapid mass loss. Numerical modeling of atmospheres with periodic shocks is being pursued to study the processes involved and the evolutionary consequences for the stars. It is characteristic of these complex dynamical systems that most effects result from the interaction of various time-dependent processes.

  13. Fire spread in chaparral: comparison of data with flame-mass loss relationships

    Science.gov (United States)

    David R. Weise; Thomas H. Fletcher; Shankar Mahalingam; Xiangyang Zhou; Lulu Sun

    2017-01-01

    The relationships between flame length, mass loss rate, and the Froude number have become well-established for many different fuels over the past 60 years. Chaparral, a mixture of shrub plants from the Mediterranean climate zone of southwestern North America, represents a fuel type—living plants—that has seldom been included in the development of these relationships....

  14. Effect of rotational mixing and metallicity on the hot star wind mass-loss rates

    Czech Academy of Sciences Publication Activity Database

    Krtička, J.; Kubát, Jiří

    2014-01-01

    Roč. 567, July (2014), A63/1-A63/7 ISSN 0004-6361 R&D Projects: GA ČR GA13-10589S Grant - others:GA MŠk(CZ) LM2010005 Institutional support: RVO:67985815 Keywords : stars: winds * outflows * stars: mass-loss Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 4.378, year: 2014

  15. Comparison of the Heat Release Rate from the Mass Loss Calorimeter to the Cone Calorimeter for Wood-based Materials

    Science.gov (United States)

    Laura E. Hasburgh; Robert H. White; Mark A. Dietenberger; Charles R. Boardman

    2015-01-01

    There is a growing demand for material properties to be used as inputs in fi re behavior models designed to address building fire safety. This comparative study evaluates using the mass loss calorimeter as an alternative to the cone calorimeter for obtaining heat release rates of wood-based materials. For this study, a modified mass loss calorimeter utilized an...

  16. Accelerated modern human–induced species losses: Entering the sixth mass extinction

    Science.gov (United States)

    Ceballos, Gerardo; Ehrlich, Paul R.; Barnosky, Anthony D.; García, Andrés; Pringle, Robert M.; Palmer, Todd M.

    2015-01-01

    The oft-repeated claim that Earth’s biota is entering a sixth “mass extinction” depends on clearly demonstrating that current extinction rates are far above the “background” rates prevailing between the five previous mass extinctions. Earlier estimates of extinction rates have been criticized for using assumptions that might overestimate the severity of the extinction crisis. We assess, using extremely conservative assumptions, whether human activities are causing a mass extinction. First, we use a recent estimate of a background rate of 2 mammal extinctions per 10,000 species per 100 years (that is, 2 E/MSY), which is twice as high as widely used previous estimates. We then compare this rate with the current rate of mammal and vertebrate extinctions. The latter is conservatively low because listing a species as extinct requires meeting stringent criteria. Even under our assumptions, which would tend to minimize evidence of an incipient mass extinction, the average rate of vertebrate species loss over the last century is up to 100 times higher than the background rate. Under the 2 E/MSY background rate, the number of species that have gone extinct in the last century would have taken, depending on the vertebrate taxon, between 800 and 10,000 years to disappear. These estimates reveal an exceptionally rapid loss of biodiversity over the last few centuries, indicating that a sixth mass extinction is already under way. Averting a dramatic decay of biodiversity and the subsequent loss of ecosystem services is still possible through intensified conservation efforts, but that window of opportunity is rapidly closing. PMID:26601195

  17. Accelerated modern human-induced species losses: Entering the sixth mass extinction.

    Science.gov (United States)

    Ceballos, Gerardo; Ehrlich, Paul R; Barnosky, Anthony D; García, Andrés; Pringle, Robert M; Palmer, Todd M

    2015-06-01

    The oft-repeated claim that Earth's biota is entering a sixth "mass extinction" depends on clearly demonstrating that current extinction rates are far above the "background" rates prevailing between the five previous mass extinctions. Earlier estimates of extinction rates have been criticized for using assumptions that might overestimate the severity of the extinction crisis. We assess, using extremely conservative assumptions, whether human activities are causing a mass extinction. First, we use a recent estimate of a background rate of 2 mammal extinctions per 10,000 species per 100 years (that is, 2 E/MSY), which is twice as high as widely used previous estimates. We then compare this rate with the current rate of mammal and vertebrate extinctions. The latter is conservatively low because listing a species as extinct requires meeting stringent criteria. Even under our assumptions, which would tend to minimize evidence of an incipient mass extinction, the average rate of vertebrate species loss over the last century is up to 100 times higher than the background rate. Under the 2 E/MSY background rate, the number of species that have gone extinct in the last century would have taken, depending on the vertebrate taxon, between 800 and 10,000 years to disappear. These estimates reveal an exceptionally rapid loss of biodiversity over the last few centuries, indicating that a sixth mass extinction is already under way. Averting a dramatic decay of biodiversity and the subsequent loss of ecosystem services is still possible through intensified conservation efforts, but that window of opportunity is rapidly closing.

  18. A one-year resistance training program following weight loss has no significant impact on body composition and energy expenditure in postmenopausal women living with overweight and obesity.

    Science.gov (United States)

    Hintze, Luzia Jaeger; Messier, Virginie; Lavoie, Marie-Ève; Brochu, Martin; Lavoie, Jean-Marc; Prud'homme, Denis; Rabasa-Lhoret, Rémi; Doucet, Éric

    2018-05-15

    Resistance training (RT) has been shown to decrease fat mass (FM), and increase fat-free mass (FFM), which can be a useful for weight loss maintenance. To examine the effects of a 1-year RT intervention on weight loss maintenance following a 6-month dietary weight loss intervention. Following a 6-month dietary weight loss intervention (-6% ± 5.8; 5.05 kg ± 4.45), 70 postmenopausal women living with overweight or obesity were randomized to a control group (n = 34) or a RT group (n = 36) (3×/week first 6 months, 2×/week last 6 months, 70-80% of 1-repetition maximum). Body composition (DXA), abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) (CT scan), resting energy expenditure (EE) (indirect calorimetry), physical activity EE and total daily EE were measured (doubly-labelled water). A total of 54 participants completed the study (control group n = 29; RT group n = 25) and compliance to the RT program was on average 64%. Significant regains were noted for body weight 0.98 (3.71) kg vs. 1.33 (3.94) kg and FM regain 1.32 (2.69) kg vs. 0.81 (3.26) kg in control and RT groups after the 1-year weight maintenance phase. No group differences were noted. Resting EE and total daily EE did not change after the weight maintenance phase, and no differences were observed between groups. Both groups had significantly greater than predicted decrease in resting EE after the 6-month dietary intervention and at the end of the 1-year weight-loss maintenance phase. Our results suggest that a 1-year RT intervention following a 6-month dietary weight loss intervention does not improve weight loss maintenance, body composition or EE in post-menopausal women living with overweight or obesity. Copyright © 2018 Elsevier Inc. All rights reserved.

  19. Mass and loss analysis of a space-type radiation cooled insulated DC transmission line

    International Nuclear Information System (INIS)

    Schwarze, g.E.

    1986-01-01

    As both the power levels and transmission distances increase such as for large future nuclear power systems, the transmission line becomes an important element in the power chain between the source and load bus. Thus, the transmission line's characteristics must be determined so that the effect of these characteristics on the total power system can be assessed. These design characteristics include the specific mass, percent power loss, size, voltage and power levels, and operating temperatures of the conductor and insulating materials. In a previous paper, the dc transmission line's characteristics of a noninsulated solid cylindrical conductor were determined. In that analysis the expression derived for the transmission line's mass only included the conductor mass and the operating temperature of the line was that of the conductor. In the analysis of this paper, a single layer of insulation is added to the solid cylindrical conductor. In this analysis the dependency of the dc transmission line's mass, loss, and size on the power and voltage levels, conductor and insulation surface temperatures, transmission distance, and conductor and insulation material properties is determined. This analysis can be extended to multi-layers of insulation but the complexity of the analysis increases as the number of layers increase

  20. Winter reduction in body mass in a very small, nonhibernating mammal: consequences for heat loss and metabolic rates.

    Science.gov (United States)

    Taylor, Jan R E; Rychlik, Leszek; Churchfield, Sara

    2013-01-01

    Low temperatures in northern winters are energetically challenging for mammals, and a special energetic burden is expected for diminutive species like shrews, which are among the smallest of mammals. Surprisingly, shrews shrink their body size in winter and reduce body and brain mass, an effect known as Dehnel's phenomenon, which is suggested to lower absolute energy intake requirements and thereby enhance survival when food availability is low. Yet reduced body size coupled with higher body-surface-to-mass ratio in these tiny mammals may result in thermoregulatory heat production at a given temperature constituting a larger proportion of the total energy expenditure. To evaluate energetic consequences of reduced body size in winter, we investigated common shrews Sorex araneus in northeastern Poland. Average body mass decreased by 19.0% from summer to winter, and mean skull depth decreased by 13.1%. There was no difference in Dehnel's phenomenon between years despite different weather conditions. The whole-animal thermal conductance (proportional to absolute heat loss) in shrews was 19% lower in winter than in summer; the difference between the two seasons remained significant after correcting for body mass and was caused by improved fur insulation in winter. Thermogenic capacity of shrews, although much enhanced in winter, did not reach its full potential of increase, and this corresponded with relatively mild subnivean temperatures. These findings indicate that, despite their small body size, shrews effectively decrease their costs of thermoregulation. The recorded decrease in body mass from summer to winter resulted in a reduction of overall resting metabolic rate (in thermoneutrality) by 18%. This, combined with the reduced heat loss, should translate to food requirements that are substantially lower than would be the case if shrews did not undergo seasonal decrease in body mass.

  1. [Intra-Articular Application of Tranexamic Acid Significantly Reduces Blood Loss and Transfusion Requirement in Primary Total Knee Arthroplasty].

    Science.gov (United States)

    Lošťák, J; Gallo, J; Špička, J; Langová, K

    2016-01-01

    PURPOSE OF THE STUDY The aim of this prospective study was to investigate the effect of topical application of tranexamic acid (TXA, Exacyl) on the amount of post-operative blood loss, and blood transfusion requirement in patients undergoing primary total knee arthroplasty (TKA). Attention was paid to early complications potentially associated with TXA administration, such as haematoma, wound exudate, or knee swelling. In addition, the economic benefit of TXA treatment was also taken into account. MATERIAL AND METHODS The study included 238 patients (85 men and 153 women) who underwent primary total knee arthroplasty (TKA) at our department between January 2013 and November 2015. A group of 119 patients (41 men and 78 women) received intraarticular TXA injections according to the treatment protocol (TXA group). A control group matched in basic characteristics to the TXA group also consisted of 119 patients. The average age in the TXA group was 69.8 years, and the most frequent indication for TKA surgery was primary knee osteoarthritis (81.5%). In each patient, post-operative volume of blood lost from drains and total blood loss including hidden blood loss were recorded, as well as post-operative haemoglobin and haematocrit levels. On discharge of each patient from hospital, the size and site of a haematoma; wound exudate, if present after post-operative day 4; joint swelling; range of motion and early revision surgery, if performed, were evaluated. Requirements of analgesic drugs after surgery were also recorded. RESULTS In the TXA group, blood losses from drains were significantly lower than in the control group (456.7 ± 270.8 vs 640.5 ±448.2; p = 0.004). The median value for blood losses from drains was lower by 22% and the average value for total blood loss, including hidden losses, was also lower than in the control group (762.4 ± 345.2 ml vs 995.5 ± 457.3 ml). The difference in the total amount of blood loss between the two groups was significant (p = 0

  2. Constraints on continental crustal mass loss via chemical weathering using lithium and its isotopes

    Science.gov (United States)

    Rudnick, R. L.; Liu, X. M.

    2012-04-01

    The continental crust has an "intermediate" bulk composition that is distinct from primary melts of peridotitic mantle (basalt or picrite). This mismatch between the "building blocks" and the "edifice" that is the continental crust points to the operation of processes that preferentially remove mafic to ultramafic material from the continents. Such processes include lower crustal recycling (via density foundering or lower crustal subduction - e.g., relamination, Hacker et al., 2011, EPSL), generation of evolved melts via slab melting, and/or chemical weathering. Stable isotope systems point to the influence of chemical weathering on the bulk crust composition: the oxygen isotope composition of the bulk crust is distinctly heavier than that of primary, mantle-derived melts (Simon and Lecuyer, 2005, G-cubed) and the Li isotopic composition of the bulk crust is distinctly lighter than that of mantle-derive melts (Teng et al., 2004, GCA; 2008, Chem. Geol.). Both signatures mark the imprint of chemical weathering on the bulk crust composition. Here, we use a simple mass balance model for lithium inputs and outputs from the continental crust to quantify the mass lost due to chemical weathering. We find that a minimum of 15%, a maximum of 60%, and a best estimate of ~40% of the original juvenile rock mass may have been lost via chemical weathering. The accumulated percentage of mass loss due to chemical weathering leads to an average global chemical weathering rate (CWR) of ~ 1×10^10 to 2×10^10 t/yr since 3.5 Ga, which is about an order of magnitude higher than the minimum estimates based on modern rivers (Gaillardet et al., 1999, Chem. Geol.). While we cannot constrain the exact portion of crustal mass loss via chemical weathering, given the uncertainties of the calculation, we can demonstrate that the weathering flux is non-zero. Therefore, chemical weathering must play a role in the evolution of the composition and mass of the continental crust.

  3. Multifocal Gastric Ulcers Caused by Diffuse Large B Cell Lymphoma in a Patient With Significant Weight Loss

    OpenAIRE

    Gromski, Mark A.; Peng, Jennifer L.; Zhou, Jiehao; Masuoka, Howard C.; Suvannasankha, Attaya; Liangpunsakul, Suthat

    2016-01-01

    Primary gastrointestinal (GI) lymphoma is a heterogeneous disease with varied clinical presentations. The stomach is the most common GI site and accounts for 70% to 75% of GI lymphomas. We present a patient with gastric diffuse large B cell lymphoma (DLBCL) who presented with significant weight loss, early satiety, and multifocal ulcerated gastric lesions. Esophagoduodenoscopy should be performed in patients presenting with warning symptoms as in our case. Diagnosis is usually made by endosco...

  4. Episodic mass loss from the hydrogen-deficient central star of the planetary nebula Longmore 4

    Energy Technology Data Exchange (ETDEWEB)

    Bond, Howard E., E-mail: heb11@psu.edu [Current address: Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802, USA. (United States)

    2014-09-01

    A spectacular transient mass-loss episode from the extremely hot, hydrogen-deficient central star of the planetary nebula (PN) Longmore 4 (Lo 4) was discovered in 1992 by Werner et al. During that event, the star temporarily changed from its normal PG 1159 spectrum to that of an emission-line low-luminosity early-type Wolf-Rayet [WCE] star. After a few days, Lo 4 reverted to its normal, predominantly absorption-line PG 1159 type. To determine whether such events recur, and if so how often, I monitored the optical spectrum of Lo 4 from early 2003 to early 2012. Out of 81 spectra taken at random dates, 4 of them revealed mass-loss outbursts similar to that seen in 1992. This indicates that the episodes recur approximately every 100 days (if the recurrence rate has been approximately constant and the duration of a typical episode is ∼5 days), and that the star is in a high-mass-loss state about 5% of the time. Since the enhanced stellar wind is hydrogen-deficient, it arises from the photosphere and is unlikely to be related to phenomena such as a binary or planetary companion or infalling dust. I speculate on plausible mechanisms for these unique outbursts, including the possibility that they are related to the non-radial GW Vir-type pulsations exhibited by Lo 4. The central star of the PN NGC 246 has stellar parameters similar to those of Lo 4, and it is also a GW Vir-type pulsator with similar pulsation periods. I obtained 167 spectra of NGC 246 between 2003 and 2011, but no mass ejections were found.

  5. Significance of MPEG-7 textural features for improved mass detection in mammography.

    Science.gov (United States)

    Eltonsy, Nevine H; Tourassi, Georgia D; Fadeev, Aleksey; Elmaghraby, Adel S

    2006-01-01

    The purpose of the study is to investigate the significance of MPEG-7 textural features for improving the detection of masses in screening mammograms. The detection scheme was originally based on morphological directional neighborhood features extracted from mammographic regions of interest (ROIs). Receiver Operating Characteristics (ROC) was performed to evaluate the performance of each set of features independently and merged into a back-propagation artificial neural network (BPANN) using the leave-one-out sampling scheme (LOOSS). The study was based on a database of 668 mammographic ROIs (340 depicting cancer regions and 328 depicting normal parenchyma). Overall, the ROC area index of the BPANN using the directional morphological features was Az=0.85+/-0.01. The MPEG-7 edge histogram descriptor-based BPNN showed an ROC area index of Az=0.71+/-0.01 while homogeneous textural descriptors using 30 and 120 channels helped the BPNN achieve similar ROC area indexes of Az=0.882+/-0.02 and Az=0.877+/-0.01 respectively. After merging the MPEG-7 homogeneous textural features with the directional neighborhood features the performance of the BPANN increased providing an ROC area index of Az=0.91+/-0.01. MPEG-7 homogeneous textural descriptor significantly improved the morphology-based detection scheme.

  6. Impact of energy loss index on left ventricular mass regression after aortic valve replacement.

    Science.gov (United States)

    Koyama, Terumasa; Okura, Hiroyuki; Kume, Teruyoshi; Fukuhara, Kenzo; Imai, Koichiro; Hayashida, Akihiro; Neishi, Yoji; Kawamoto, Takahiro; Tanemoto, Kazuo; Yoshida, Kiyoshi

    2014-01-01

    Recently, the energy loss index (ELI) has been proposed as a new functional index to assess the severity of aortic stenosis (AS). The aim of this study was to investigate the impact of the ELI on left ventricular mass (LVM) regression in patients after aortic valve replacement (AVR) with mechanical valves. A total of 30 patients with severe AS who underwent AVR with mechanical valves was studied. Echocardiography was performed to measure the LVM before AVR (pre-LVM) (n = 30) and repeated 12 months later (post-LVM) (n = 19). The ELI was calculated as [effective orifice area (EOA) × aortic cross sectional area]/(aortic cross sectional area - EOA) divided by the body surface area. The LVM regression rate (%) was calculated as 100 × (post-LVM - pre-LVM)/(pre-LVM). A cardiac event was defined as a composite of cardiac death and heart failure requiring hospitalization. LVM regressed significantly (245.1 ± 84.3 to 173.4 ± 62.6 g, P regression rate negatively correlated with the ELI (R = -0.67, P regression rates (area under the curve = 0.825; P = 0.030). Patients with ELI regression after AVR with mechanical valves. Whether the ELI is a stronger predictor of clinical events than EOAI is still unclear, and further large-scale study is necessary to elucidate the clinical impact of the ELI in patients with AVR.

  7. HOW THERMAL EVOLUTION AND MASS-LOSS SCULPT POPULATIONS OF SUPER-EARTHS AND SUB-NEPTUNES: APPLICATION TO THE KEPLER-11 SYSTEM AND BEYOND

    International Nuclear Information System (INIS)

    Lopez, Eric D.; Miller, Neil; Fortney, Jonathan J.

    2012-01-01

    We use models of thermal evolution and extreme ultraviolet (XUV) driven mass loss to explore the composition and history of low-mass, low-density transiting planets. We investigate the Kepler-11 system in detail and provide estimates of both the current and past planetary compositions. We find that an H/He envelope on Kepler-11b is highly vulnerable to mass loss. By comparing to formation models, we show that in situ formation of the system is extremely difficult. Instead we propose that it is a water-rich system of sub-Neptunes that migrated from beyond the snow line. For the broader population of observed planets, we show that there is a threshold in bulk planet density and incident flux above which no low-mass transiting planets have been observed. We suggest that this threshold is due to the instability of H/He envelopes to XUV-driven mass loss. Importantly, we find that this mass-loss threshold is well reproduced by our thermal evolution/contraction models that incorporate a standard mass-loss prescription. Treating the planets' contraction history is essential because the planets have significantly larger radii during the early era of high XUV fluxes. Over time low-mass planets with H/He envelopes can be transformed into water-dominated worlds with steam envelopes or rocky super-Earths. Finally, we use this threshold to provide likely minimum masses and radial-velocity amplitudes for the general population of Kepler candidates. Likewise, we use this threshold to provide constraints on the maximum radii of low-mass planets found by radial-velocity surveys.

  8. Transient Mass-loss Analysis of Solar Observations Using Stellar Methods

    Energy Technology Data Exchange (ETDEWEB)

    Crosley, M. K.; Norman, C. [Johns Hopkins University, Department of Physics and Astronomy, 3400 N. Charles Street, Baltimore, MD 21218 (United States); Osten, R. A. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States)

    2017-08-10

    Low-frequency dynamic spectra of radio bursts from nearby stars offer the best chance to directly detect the stellar signature of transient mass loss on low-mass stars. Crosley et al. (2016) proposes a multi-wavelength methodology to determine coronal mass ejection (CME) parameters, such as speed, mass, and kinetic energy. We test the validity and accuracy of the results derived from the methodology by using Geostationary Operational Environmental Satellite X-ray observations and Bruny Island Radio Spectrometer radio observations. These are analogous observations to those that would be found in the stellar studies. Derived results from these observations are compared to direct white light measurements of the Large Angle and Spectrometric Coronagraph. We find that, when a pre-event temperature can be determined, the accuracy of CME speeds are within a few hundred km s{sup −1}, and are reliable when specific criteria has been met. CME mass and kinetic energies are only useful in determining the approximate order of magnitude measurements when considering the large errors associated to them. These results will be directly applicable to the interpretation of any detected stellar events and the derivation of stellar CME properties.

  9. GAS LOSS BY RAM PRESSURE STRIPPING AND INTERNAL FEEDBACK FROM LOW-MASS MILKY WAY SATELLITES

    Energy Technology Data Exchange (ETDEWEB)

    Emerick, Andrew; Low, Mordecai-Mark Mac [Department of Astronomy, Columbia University, New York, NY (United States); Grcevich, Jana [Department of Astrophysics, American Museum of Natural History, New York, NY (United States); Gatto, Andrea [Max-Planck-Institute für Astrophysik, Garching, bei München (Germany)

    2016-08-01

    The evolution of dwarf satellites in the Milky Way (MW) is affected by a combination of ram pressure stripping (RPS), tidal stripping, and internal feedback from massive stars. We investigate gas loss processes in the smallest satellites of the MW using three-dimensional, high-resolution, idealized wind tunnel simulations, accounting for gas loss through both ram pressure stripping and expulsion by supernova feedback. Using initial conditions appropriate for a dwarf galaxy like Leo T, we investigate whether or not environmental gas stripping and internal feedback can quench these low-mass galaxies on the expected timescales, shorter than 2 Gyr. We find that supernova feedback contributes negligibly to the stripping rate for these low star formation rate galaxies. However, we also find that RPS is less efficient than expected in the stripping scenarios we consider. Our work suggests that although RPS can eventually completely strip these galaxies, other physics is likely at play to reconcile our computed stripping times with the rapid quenching timescales deduced from observations of low-mass MW dwarf galaxies. We discuss the roles additional physics may play in this scenario, including host-satellite tidal interactions, cored versus cuspy dark matter profiles, reionization, and satellite preprocessing. We conclude that a proper accounting of these physics together is necessary to understand the quenching of low-mass MW satellites.

  10. Multifocal Gastric Ulcers Caused by Diffuse Large B Cell Lymphoma in a Patient With Significant Weight Loss

    Directory of Open Access Journals (Sweden)

    Mark A. Gromski MD

    2016-12-01

    Full Text Available Primary gastrointestinal (GI lymphoma is a heterogeneous disease with varied clinical presentations. The stomach is the most common GI site and accounts for 70% to 75% of GI lymphomas. We present a patient with gastric diffuse large B cell lymphoma (DLBCL who presented with significant weight loss, early satiety, and multifocal ulcerated gastric lesions. Esophagoduodenoscopy should be performed in patients presenting with warning symptoms as in our case. Diagnosis is usually made by endoscopic biopsies. Multiple treatment modalities including surgery, radiotherapy, and chemotherapy have been used. Advancements in endoscopic and pathologic technology decrease turnaround time for diagnosis and treatment initiation, thus reducing the need for surgery. Health care providers should maintain a high level of suspicion and consider gastric DLBCL as part of the differential diagnosis, especially in those with warning symptoms such as weight loss and early satiety with abnormal endoscopic findings.

  11. Equation of motion of an interstellar Bussard ramjet with radiation and mass losses

    International Nuclear Information System (INIS)

    Semay, Claude; Silvestre-Brac, Bernard

    2008-01-01

    An interstellar Bussard ramjet is a spaceship using the protons of the interstellar medium in a fusion engine to produce thrust. In recent papers, it was shown that the relativistic equation of motion of an ideal ramjet and that of a ramjet with radiation loss are analytical. When a mass loss appears, the limit speed of the ramjet is more strongly reduced. However, the parametric equations in terms of the ramjet's speed for the position of the ramjet in the inertial frame of the interstellar medium, the time in this frame and the proper time indicated by the clocks on board the spaceship can still be obtained in an analytical form. The non-relativistic motion and the motion near the limit speed are studied

  12. Equation of motion of an interstellar Bussard ramjet with radiation and mass losses

    Energy Technology Data Exchange (ETDEWEB)

    Semay, Claude [Groupe de Physique Nucleaire Theorique, Universite de Mons-Hainaut, Academie universitaire Wallonie-Bruxelles, Place du Parc 20, B-7000 Mons (Belgium); Silvestre-Brac, Bernard [LPSC, Universite Joseph Fourier, Grenoble 1, CNRS/IN2P3, Institut Polytechnique de Grenoble, Avenue des Martyrs 53, F-38026 Grenoble-Cedex (France)], E-mail: claude.semay@umh.ac.be, E-mail: silvestre@lpsc.in2p3.fr

    2008-11-15

    An interstellar Bussard ramjet is a spaceship using the protons of the interstellar medium in a fusion engine to produce thrust. In recent papers, it was shown that the relativistic equation of motion of an ideal ramjet and that of a ramjet with radiation loss are analytical. When a mass loss appears, the limit speed of the ramjet is more strongly reduced. However, the parametric equations in terms of the ramjet's speed for the position of the ramjet in the inertial frame of the interstellar medium, the time in this frame and the proper time indicated by the clocks on board the spaceship can still be obtained in an analytical form. The non-relativistic motion and the motion near the limit speed are studied.

  13. A Conceptual Analysis of Mass Loss and Frequency Redistribution in Wolf-Rayet Winds

    OpenAIRE

    Onifer, A. J.; Gayley, K. G.

    2007-01-01

    To better understand Wolf-Rayet stars as progenitors of gamma-ray bursts, an understanding of the effect metallicity has on Wolf-Rayet mass loss is needed. Using simple analytic models, we study the Mdot - Z relation of a WN star and compare the results to similar models. We find that Mdot roughly follows a power law in Z with index 0.88 from -2.5 < log Z/Z_sun < -1 and appears to flatten by log Z/Z_sun ~ -0.5.

  14. Radio Photosphere and Mass-Loss Envelope of VY Canis Majoris

    Science.gov (United States)

    Lipscy, S. J.; Jura, M.; Reid, M. J.

    2005-06-01

    We have used the VLA to detect emission from the supergiant VY CMa at radio wavelengths and have constructed 3000-4500 K isothermal outer atmospheres constrained by the data. These models produce a radio photosphere at 1.5-2 R*. An extrapolation of the model can account for the observed total mass-loss rate of the star. We also present mid-infrared imaging of the supergiant which suggests that warm dust is extended in the same direction as the near-infrared reflection nebula around VY CMa. The origin of the asymmetries in the outflow remains an unsolved problem.

  15. Mass-loss evolution of close-in exoplanets: Evaporation of hot Jupiters and the effect on population

    International Nuclear Information System (INIS)

    Kurokawa, H.; Nakamoto, T.

    2014-01-01

    During their evolution, short-period exoplanets may lose envelope mass through atmospheric escape owing to intense X-ray and extreme ultraviolet (XUV) radiation from their host stars. Roche-lobe overflow induced by orbital evolution or intense atmospheric escape can also contribute to mass loss. To study the effects of mass loss on inner planet populations, we calculate the evolution of hot Jupiters considering mass loss of their envelopes and thermal contraction. Mass loss is assumed to occur through XUV-driven atmospheric escape and the following Roche-lobe overflow. The runaway effect of mass loss results in a dichotomy of populations: hot Jupiters that retain their envelopes and super Earths whose envelopes are completely lost. Evolution primarily depends on the core masses of planets and only slightly on migration history. In hot Jupiters with small cores (≅ 10 Earth masses), runaway atmospheric escape followed by Roche-lobe overflow may create sub-Jupiter deserts, as observed in both mass and radius distributions of planetary populations. Comparing our results with formation scenarios and observed exoplanets populations, we propose that populations of closely orbiting exoplanets are formed by capturing planets at/inside the inner edges of protoplanetary disks and subsequent evaporation of sub-Jupiters.

  16. Mass-loss evolution of close-in exoplanets: Evaporation of hot Jupiters and the effect on population

    Energy Technology Data Exchange (ETDEWEB)

    Kurokawa, H. [Department of Physics, Nagoya Univsersity, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8602 (Japan); Nakamoto, T., E-mail: kurokawa@nagoya-u.jp [Department of Earth and Planetary Sciences, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8551 (Japan)

    2014-03-01

    During their evolution, short-period exoplanets may lose envelope mass through atmospheric escape owing to intense X-ray and extreme ultraviolet (XUV) radiation from their host stars. Roche-lobe overflow induced by orbital evolution or intense atmospheric escape can also contribute to mass loss. To study the effects of mass loss on inner planet populations, we calculate the evolution of hot Jupiters considering mass loss of their envelopes and thermal contraction. Mass loss is assumed to occur through XUV-driven atmospheric escape and the following Roche-lobe overflow. The runaway effect of mass loss results in a dichotomy of populations: hot Jupiters that retain their envelopes and super Earths whose envelopes are completely lost. Evolution primarily depends on the core masses of planets and only slightly on migration history. In hot Jupiters with small cores (≅ 10 Earth masses), runaway atmospheric escape followed by Roche-lobe overflow may create sub-Jupiter deserts, as observed in both mass and radius distributions of planetary populations. Comparing our results with formation scenarios and observed exoplanets populations, we propose that populations of closely orbiting exoplanets are formed by capturing planets at/inside the inner edges of protoplanetary disks and subsequent evaporation of sub-Jupiters.

  17. Galactic chemical evolution with main-sequence mass loss and the distribution of F and G dwarfs

    International Nuclear Information System (INIS)

    Guzik, J.A.; Struck-Marcell, C.

    1988-01-01

    Simple closed galactic chemical-evolution models incorporating early main-sequence stellar mass loss have been developed for disk ages of 5, 10, and 15 Gyr. Relative to models without stellar mass loss, the models are shown to produce a 30-60 percent increase in the present mass ratio of dwarfs to dwarfs plus remnants, and a 200-250 percent increase in the total mass of late F dwarfs remaining on the main sequence at the current disk age. For present disk ages 5 and 10 Gyr, the total mass of mid-F dwarfs remaining on the main sequence is also shown to increase by 90-120 percent. It is concluded that models with main-sequence mass loss have a slightly reduced gas metallicity and slightly increased gas fraction midway through the evolution. 30 references

  18. A path model of sarcopenia on bone mass loss in elderly subjects.

    Science.gov (United States)

    Rondanelli, M; Guido, D; Opizzi, A; Faliva, M A; Perna, S; Grassi, M

    2014-01-01

    Aging is associated with decreases in muscle mass, strength, power (sarcopenia) and bone mineral density (BMD). The aims of this study were to investigate in elderly the role of sarcopenia on BMD loss by a path model, including adiposity, inflammation, and malnutrition associations. Body composition and BMD were measured by dual X-ray absorptiometry in 159 elderly subjects (52 male/107 female; mean age 80.3 yrs). Muscle strength was determined with dynamometer. Serum albumin and PCR were also assessed. Structural equations examined the effect of sarcopenia (measured by Relative Skeletal Muscle Mass, Total Muscle Mass, Handgrip, Muscle Quality Score) on osteoporosis (measured by Vertebral and Femoral T-scores) in a latent variable model including adiposity (measured by Total Fat Mass, BMI, Ginoid/Android Fat), inflammation (PCR), and malnutrition (serum albumin). The sarcopenia assumed a role of moderator in the adiposity-osteoporosis relationship. Specifically, increasing the sarcopenia, the relationship adiposity-osteoporosis (β: -0.58) decrease in intensity. Adiposity also influences sarcopenia (β: -0.18). Malnutrition affects the inflammatory and the adiposity states (β: +0.61, and β: -0.30, respectively), while not influencing the sarcopenia. Thus, adiposity has a role as a mediator of the effect of malnutrition on both sarcopenia and osteoporosis. Malnutrition decreases adiposity; decreasing adiposity, in turn, increase the sarcopenia and osteoporosis. This study suggests such as in a group of elderly sarcopenia affects the link between adiposity and BMD, but not have a pure independent effect on osteoporosis.

  19. Significant reduction of saturation magnetization and microwave-reflection loss in barium-natural ferrite via Nd3+ substitution

    Science.gov (United States)

    Widanarto, W.; Ardenti, E.; Ghoshal, S. K.; Kurniawan, C.; Effendi, M.; Cahyanto, W. T.

    2018-06-01

    To minimize the signal degradation, many electronic devices require efficient microwave absorbers with very low reflection-losses within the X-band. We prepared a series of trivalent neodymium-ion (Nd3+) substituted barium-natural ferrite using a modified solid-state reaction method. The effect of the Nd3+-ion content on the structure, surface morphology, magnetic properties, and microwave reflection loss was studied. The composites were characterized using X-ray diffraction, a vibrating sample magnetometer, scanning electron microscopy, and a vector network analyzer. The XRD patterns of the sample without Nd3+ reveal the presence of BaFe12O19 (hexagonal) and BaFe2O4 (rhombohedral) phases. Furthermore, a new hexagonal crystal phase of Ba6Nd2Fe4O15 appeared after substituting Nd3+. The average size of the prepared barium-natural ferrite particles was estimated to be between 0.4 and 0.8 μm. Both saturation magnetization and microwave reflection losses of these barium-ferrites were significantly reduced by increasing the Nd3+ content.

  20. Increased meal frequency attenuates fat-free mass losses and some markers of health status with a portion-controlled weight loss diet.

    Science.gov (United States)

    Alencar, Michelle K; Beam, Jason R; McCormick, James J; White, Ailish C; Salgado, Roy M; Kravitz, Len R; Mermier, Christine M; Gibson, Ann L; Conn, Carole A; Kolkmeyer, Deborah; Ferraro, Robert T; Kerksick, Chad M

    2015-05-01

    Increased meal frequency (MF) may be associated with improvements in blood markers of health and body composition during weight loss; however, this claim has not been validated. The purpose of the study was to determine if either a 2-meal (2 MF) or 6-meal frequency (6 MF) regimen can improve body composition and blood-based markers of health while consuming a portion-controlled equihypocaloric diet. Eleven (N=11) obese women (52 ± 7 years, 101.7 ± 22.6 kg, 39.1 ± 7.6 kg/m(2)) were randomized into treatment condition (2 MF or 6 MF) for 2 weeks, completed a 2-week washout, and alternated treatment conditions. In pre/post fashion, changes in body composition, glucose, insulin, and lipid components were measured in response to a test meal. Body mass was successfully lost (P ≤ .05) under both feeding regimens (2 MF: -2.8 ± 1.5 vs 6 MF: -1.9 ± 1.5 kg). Altering MF did not impact glucose, insulin, total cholesterol, or low-density lipoprotein cholesterol (P>.05). On average, fat-free mass (FFM) decreased by -3.3% ± 2.6% following the 2 MF condition and, on average, increased by 1.2% ± 1.7% following the 6 MF condition (P ≤ .05). Fasting high-density lipoprotein cholesterol (HDL-C) percentage increased during the 2 MF condition; this was significantly greater than that in the 6 MF condition (1.3% ± 12.2% vs 0.12% ± 10.3%) (P ≤ .05). Overall, reductions in MF (2 MF) were associated with improved HDL-C levels; but the clinical significance is not clear. Alternatively, increased MF (6 MF) did appear to favorably preserve FFM during weight loss. In conclusion, caloric restriction was effective in reducing body mass and attenuating FFM changes in body composition; however, glucose, insulin, and lipid metabolism had no significant differences between MF. Copyright © 2015 Elsevier Inc. All rights reserved.

  1. Magnetic confinement, Alfven wave reflection, and the origins of X-ray and mass-loss 'dividing lines' for late-type giants and supergiants

    Science.gov (United States)

    Rosner, R.; An, C.-H.; Musielak, Z. E.; Moore, R. L.; Suess, S. T.

    1991-01-01

    A simple qualitative model for the origin of the coronal and mass-loss dividing lines separating late-type giants and supergiants with and without hot, X-ray-emitting corona, and with and without significant mass loss is discussed. The basic physical effects considered are the necessity of magnetic confinement for hot coronal material on the surface of such stars and the large reflection efficiency for Alfven waves in cool exponential atmospheres. The model assumes that the magnetic field geometry of these stars changes across the observed 'dividing lines' from being mostly closed on the high effective temperature side to being mostly open on the low effective temperature side.

  2. Implementation of a method to visualize noise-induced hearing loss in mass stranded cetaceans

    Science.gov (United States)

    Morell, Maria; Brownlow, Andrew; McGovern, Barry; Raverty, Stephen A.; Shadwick, Robert E.; André, Michel

    2017-02-01

    Assessment of the impact of noise over-exposure in stranded cetaceans is challenging, as the lesions that lead to hearing loss occur at the cellular level and inner ear cells are very sensitive to autolysis. Distinguishing ante-mortem pathology from post-mortem change has been a major constraint in diagnosing potential impact. Here, we outline a methodology applicable to the detection of noise-induced hearing loss in stranded cetaceans. Inner ears from two mass strandings of long-finned pilot whales in Scotland were processed for scanning electron microscopy observation. In one case, a juvenile animal, whose ears were fixed within 4 hours of death, revealed that many sensory cells at the apex of the cochlear spiral were missing. In this case, the absence of outer hair cells would be compatible with overexposure to underwater noise, affecting the region which transduces the lowest frequencies of the pilot whales hearing spectrum. Perfusion of cochlea with fixative greatly improved preservation and enabled diagnostic imaging of the organ of Corti, even 30 hours after death. This finding supports adopting a routine protocol to detect the pathological legacy of noise overexposure in mass stranded cetaceans as a key to understanding the complex processes and implications that lie behind such stranding events.

  3. Mass loss, levitation, accretion, and the sharp-lined features in hot white dwarfs

    International Nuclear Information System (INIS)

    Bruhweiler, F.C.; Kondo, Y.

    1983-01-01

    We have studied eight white dwarfs, seven DA and one He-rich types, observed at a high resolution (lambda/Δlambdaroughly-equal10 4 ) with the International Ultraviolet Explorer (IUE). Of the seven DA white dwarfs, three show spectral signatures of ionized heavy elements, such as Si II, SI III, C IV, Si IV, and N V, arising in the immediate environment of these stars. The shortward-shifted lines in two (G191--B2B and 2111+49) of the three DA types showing metallic lines are tentatively interpreted as an indication of mass loss from these stars. The He-rich white dwarf shows the features due to C cV and He II, which also arise in the immediate environment of that star. Although the statistical sample presented here is limited, we tentatively suggest a temperature and effective gravity range (T/sub eff/> or approx. =20,000 K and log (g) < or approx. =8.0) in DA white dwarfs within which metallic lines are present either in the photosphere or in the halo of the stars. We examine the physical processes relevant to the appearance of such metallic lines. We tentatively propose that radiative levitation can explain the appearance of the observed lines in the hot DA white dwarfs, although the role of radiation forces in mass loss is not clear

  4. Atmospheric mass-loss of extrasolar planets orbiting magnetically active host stars

    Science.gov (United States)

    Lalitha, Sairam; Schmitt, J. H. M. M.; Dash, Spandan

    2018-06-01

    Magnetic stellar activity of exoplanet hosts can lead to the production of large amounts of high-energy emission, which irradiates extrasolar planets, located in the immediate vicinity of such stars. This radiation is absorbed in the planets' upper atmospheres, which consequently heat up and evaporate, possibly leading to an irradiation-induced mass-loss. We present a study of the high-energy emission in the four magnetically active planet-bearing host stars, Kepler-63, Kepler-210, WASP-19, and HAT-P-11, based on new XMM-Newton observations. We find that the X-ray luminosities of these stars are rather high with orders of magnitude above the level of the active Sun. The total XUV irradiation of these planets is expected to be stronger than that of well-studied hot Jupiters. Using the estimated XUV luminosities as the energy input to the planetary atmospheres, we obtain upper limits for the total mass- loss in these hot Jupiters.

  5. Carboxylic acid functional group analysis using constant neutral loss scanning-mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Dron, Julien [Laboratoire de Chimie et Environnement, Marseille Universites (case 29), 3 place Victor Hugo, 13331 Marseille Cedex 3 (France)], E-mail: julien.dron@up.univ-mrs.fr; Eyglunent, Gregory; Temime-Roussel, Brice; Marchand, Nicolas; Wortham, Henri [Laboratoire de Chimie et Environnement, Marseille Universites (case 29), 3 place Victor Hugo, 13331 Marseille Cedex 3 (France)

    2007-12-12

    The present study describes the development of a new analytical technique for the functional group determination of the carboxylic moiety using atmospheric pressure chemical ionization-mass spectrometry (APCI-MS/MS) operated in the constant neutral loss scanning (CNLS) mode. Carboxylic groups were first derivatized into their corresponding methyl esters by reacting with BF{sub 3}/methanol mix and the reaction mixture was then directly injected into the APCI chamber. The loss of methanol (m/z = 32 amu) resulting from the fragmentation of the protonated methyl esters was then monitored. Applying this method together with a statistical approach to reference mixtures containing 31 different carboxylic acids at randomly calculated concentrations demonstrated its suitability for quantitative functional group measurements with relative standard deviations below 15% and a detection limit of 0.005 mmol L{sup -1}. Its applicability to environmental matrices was also shown through the determination of carboxylic acid concentrations inside atmospheric aerosol samples. To the best of our knowledge, it is the first time that the tandem mass spectrometry was successfully applied to functional group analysis, offering great perspectives in the characterization of complex mixtures which are prevailing in the field of environmental analysis as well as in the understanding of the chemical processes occurring in these matrices.

  6. Carboxylic acid functional group analysis using constant neutral loss scanning-mass spectrometry

    International Nuclear Information System (INIS)

    Dron, Julien; Eyglunent, Gregory; Temime-Roussel, Brice; Marchand, Nicolas; Wortham, Henri

    2007-01-01

    The present study describes the development of a new analytical technique for the functional group determination of the carboxylic moiety using atmospheric pressure chemical ionization-mass spectrometry (APCI-MS/MS) operated in the constant neutral loss scanning (CNLS) mode. Carboxylic groups were first derivatized into their corresponding methyl esters by reacting with BF 3 /methanol mix and the reaction mixture was then directly injected into the APCI chamber. The loss of methanol (m/z = 32 amu) resulting from the fragmentation of the protonated methyl esters was then monitored. Applying this method together with a statistical approach to reference mixtures containing 31 different carboxylic acids at randomly calculated concentrations demonstrated its suitability for quantitative functional group measurements with relative standard deviations below 15% and a detection limit of 0.005 mmol L -1 . Its applicability to environmental matrices was also shown through the determination of carboxylic acid concentrations inside atmospheric aerosol samples. To the best of our knowledge, it is the first time that the tandem mass spectrometry was successfully applied to functional group analysis, offering great perspectives in the characterization of complex mixtures which are prevailing in the field of environmental analysis as well as in the understanding of the chemical processes occurring in these matrices

  7. The circumstellar shells and mass loss rates of four M supergiants

    International Nuclear Information System (INIS)

    Bernat, A.P.

    1977-01-01

    A reanalysis of the physical structure of the circumstellar gas shells of four bright M supergiants, Betelgeuse, Antares, α Herculis, and μ Cephei, has been undertaken. The observational data include old Hale Observatories plates, recent McDonald Struve telescope plates, and McDonald 2.7 m photoelectric scans. These data are analyzed in the full expanding spherical geometry formulation of the radiative transfer equation.The results of the present analysis indicate that column densities in the gas shells must be revised downward compared with the previous plane-parallel results. However, the physical extents of the shells are considerably larger than previously assumed. These extents are inferred through ionization modeling, Weymann's Ca II technique, and direct observation. Also inferred are schematic wavelength-dependent chromospheric color temperatures. These results lead to much larger mass loss rates (in the range 6.7 x 10 -7 to 4.2 x 10 -4 M/sub sun/ yr -2 ) than previously inferred. The influence of these large rates of mass loss on the evolution of both stars and the Galaxy is briefly discussed

  8. Comparison between clinical significance of height-adjusted and weight-adjusted appendicular skeletal muscle mass.

    Science.gov (United States)

    Furushima, Taishi; Miyachi, Motohiko; Iemitsu, Motoyuki; Murakami, Haruka; Kawano, Hiroshi; Gando, Yuko; Kawakami, Ryoko; Sanada, Kiyoshi

    2017-02-13

    This study aimed to compare relationships between height- or weight-adjusted appendicular skeletal muscle mass (ASM/Ht 2 or ASM/Wt) and risk factors for cardiometabolic diseases or osteoporosis in Japanese men and women. Subjects were healthy Japanese men (n = 583) and women (n = 1218). The study population included a young group (310 men and 357 women; age, 18-40 years) and a middle-aged and elderly group (273 men and 861 women; age, ≥41 years). ASM was measured by dual-energy X-ray absorptiometry. The reference values for class 1 and 2 sarcopenia in each sex were defined as values one and two standard deviations below the sex-specific means of the young group, respectively. The reference values for class 1 and 2 sarcopenia defined by ASM/Ht 2 were 7.77 and 6.89 kg/m 2 in men and 6.06 and 5.31 kg/m 2 in women, respectively. The reference values for ASM/Wt were 35.0 and 32.0% in men and 29.6 and 26.4% in women, respectively. In both men and women, ASM/Wt was negatively correlated with higher triglycerides (TG) and positively correlated with serum high-density lipoprotein cholesterol (HDL-C), but these associations were not found in height-adjusted ASM. In women, TG, systolic blood pressure, and diastolic blood pressure in sarcopenia defined by ASM/Wt were significantly higher than those in normal subjects, but these associations were not found in sarcopenia defined by ASM/Ht 2 . Whole-body and regional bone mineral density in sarcopenia defined by ASM/Ht 2 were significantly lower than those in normal subjects, but these associations were not found in sarcopenia defined by ASM/Wt. Weight-adjusted definition was able to identify cardiometabolic risk factors such as TG and HDL-C while height-adjusted definition could identify factors for osteoporosis.

  9. Significance of residual abdominal masses in children with abdominal Burkitt's lymphoma

    International Nuclear Information System (INIS)

    Karmazyn, B.; Horev, G.; Kornreich, L.; Ash, S.; Goshen, Y.; Yaniv, I.

    2001-01-01

    Purpose: To evaluate the natural history of children with abdominal Burkitt's lymphoma who had complete clinical remission and residual abdominal mass after treatment. Material and methods: The charts and imaging findings of all children with abdominal Burkitt's lymphoma treated and followed at our medical center between 1988 and 1999 were reviewed for the presence, management, clinical course, and prognosis of residual mass. Results: Only children who achieved complete clinical remission were included. The study group consisted of 33 children (20 boys and 13 girls) aged 2.6-17.6 years (mean 7.2 years). Of these, seven (20.6 %) were found to have a residual abdominal mass. Two underwent second-look operation with no evidence of viable tumor on histology. The remaining five were followed by imaging studies for 2.2-9.1 years (mean 6.1 years); none relapsed. Conclusion: Residual mass is not uncommon in children with abdominal Burkitt's lymphoma. The presence of residual mass in a child with complete clinical remission does not alter the long-term prognosis. Therefore, in children with Burkitt's lymphoma and residual mass with no other signs of disease activity, expectant watching may be appropriate. (orig.)

  10. Mass loss of stars on the asymptotic giant branch. Mechanisms, models and measurements

    Science.gov (United States)

    Höfner, Susanne; Olofsson, Hans

    2018-01-01

    As low- and intermediate-mass stars reach the asymptotic giant branch (AGB), they have developed into intriguing and complex objects that are major players in the cosmic gas/dust cycle. At this stage, their appearance and evolution are strongly affected by a range of dynamical processes. Large-scale convective flows bring newly-formed chemical elements to the stellar surface and, together with pulsations, they trigger shock waves in the extended stellar atmosphere. There, massive outflows of gas and dust have their origin, which enrich the interstellar medium and, eventually, lead to a transformation of the cool luminous giants into white dwarfs. Dust grains forming in the upper atmospheric layers play a critical role in the wind acceleration process, by scattering and absorbing stellar photons and transferring their outward-directed momentum to the surrounding gas through collisions. Recent progress in high-angular-resolution instrumentation, from the visual to the radio regime, is leading to valuable new insights into the complex dynamical atmospheres of AGB stars and their wind-forming regions. Observations are revealing asymmetries and inhomogeneities in the photospheric and dust-forming layers which vary on time-scales of months, as well as more long-lived large-scale structures in the circumstellar envelopes. High-angular-resolution observations indicate at what distances from the stars dust condensation occurs, and they give information on the chemical composition and sizes of dust grains in the close vicinity of cool giants. These are essential constraints for building realistic models of wind acceleration and developing a predictive theory of mass loss for AGB stars, which is a crucial ingredient of stellar and galactic chemical evolution models. At present, it is still not fully possible to model all these phenomena from first principles, and to predict the mass-loss rate based on fundamental stellar parameters only. However, much progress has been made

  11. Mass ablation and magnetic flux losses through a magnetized plasma-liner wall interface

    Science.gov (United States)

    García-Rubio, F.; Sanz, J.

    2017-07-01

    The understanding of energy and magnetic flux losses in a magnetized plasma medium confined by a cold wall is of great interest in the success of magnetized liner inertial fusion (MagLIF). In a MagLIF scheme, the fuel is magnetized and subsonically compressed by a cylindrical liner. Magnetic flux conservation is degraded by the presence of gradient-driven transport processes such as thermoelectric effects (Nernst) and magnetic field diffusion. In previous publications [Velikovich et al., Phys. Plasmas 22, 042702 (2015)], the evolution of a hot magnetized plasma in contact with a cold solid wall (liner) was studied using the classical collisional Braginskii's plasma transport equations in one dimension. The Nernst term degraded the magnetic flux conservation, while both thermal energy and magnetic flux losses were reduced with the electron Hall parameter ωeτe with a power-law asymptotic scaling (ωeτe)-1/2. In the analysis made in the present paper, we consider a similar situation, but with the liner being treated differently. Instead of a cold solid wall acting as a heat sink, we model the liner as a cold dense plasma with low thermal conduction (that could represent the cryogenic fuel layer added on the inner surface of the liner in a high-gain MagLIF configuration). Mass ablation comes into play, which adds notably differences to the previous analysis. The direction of the plasma motion is inverted, but the Nernst term still convects the magnetic field towards the liner. Magnetization suppresses the Nernst velocity and improves the magnetic flux conservation. Thermal energy in the hot plasma is lost in heating the ablated material. When the electron Hall parameter is large, mass ablation scales as (ωeτe)-3/10, while both the energy and magnetic flux losses are reduced with a power-law asymptotic scaling (ωeτe)-7/10.

  12. The evolution of low-mass close binary systems. IV. 0.80 M/sub sun/+0.40 M/sub sun/: Catastrophic mass loss

    International Nuclear Information System (INIS)

    Webbink, R.F.

    1977-01-01

    The evolution of both components of a 0.80 M/sub sun/+0.40 M/sub sun/ binary with initial separation 1.60 R/sub sun/ is presented. This system reaches mass transfer during core hydrogen burning in the primary. The primary has such a deep convective envelope that mass transfer proceeds on a dynamical time scale. Mass exchange is followed through the first 6.25 x 10 -3 M/sub sun/, by which time the transfer rate has reached 8.33 x 10 -4 M/sub sun/ yr -1 .It is shown that mass transfer on a dynamical time scale leads to supercritical accretion by the secondary component, and hence is presumably accompanied by extensive mass and angular momentum losses. Stability against such rapid mass transfer may impose severe limitations on the masses and mass ratios of cataclysmic variables

  13. Uplift rates from a new high-density GPS network in Palmer Land indicate significant late Holocene ice loss in the southwestern Weddell Sea

    Science.gov (United States)

    Wolstencroft, Martin; King, Matt A.; Whitehouse, Pippa L.; Bentley, Michael J.; Nield, Grace A.; King, Edward C.; McMillan, Malcolm; Shepherd, Andrew; Barletta, Valentina; Bordoni, Andrea; Riva, Riccardo E. M.; Didova, Olga; Gunter, Brian C.

    2015-10-01

    The measurement of ongoing ice-mass loss and associated melt water contribution to sea-level change from regions such as West Antarctica is dependent on a combination of remote sensing methods. A key method, the measurement of changes in Earth's gravity via the GRACE satellite mission, requires a potentially large correction to account for the isostatic response of the solid Earth to ice-load changes since the Last Glacial Maximum. In this study, we combine glacial isostatic adjustment modelling with a new GPS dataset of solid Earth deformation for the southern Antarctic Peninsula to test the current understanding of ice history in this region. A sufficiently complete history of past ice-load change is required for glacial isostatic adjustment models to accurately predict the spatial variation of ongoing solid Earth deformation, once the independently-constrained effects of present-day ice mass loss have been accounted for. Comparisons between the GPS data and glacial isostatic adjustment model predictions reveal a substantial misfit. The misfit is localized on the southwestern Weddell Sea, where current ice models under-predict uplift rates by approximately 2 mm yr-1. This under-prediction suggests that either the retreat of the ice sheet grounding line in this region occurred significantly later in the Holocene than currently assumed, or that the region previously hosted more ice than currently assumed. This finding demonstrates the need for further fieldwork to obtain direct constraints on the timing of Holocene grounding line retreat in the southwestern Weddell Sea and that GRACE estimates of ice sheet mass balance will be unreliable in this region until this is resolved.

  14. Decreasing cloud cover drives the recent mass loss on the Greenland Ice Sheet.

    Science.gov (United States)

    Hofer, Stefan; Tedstone, Andrew J; Fettweis, Xavier; Bamber, Jonathan L

    2017-06-01

    The Greenland Ice Sheet (GrIS) has been losing mass at an accelerating rate since the mid-1990s. This has been due to both increased ice discharge into the ocean and melting at the surface, with the latter being the dominant contribution. This change in state has been attributed to rising temperatures and a decrease in surface albedo. We show, using satellite data and climate model output, that the abrupt reduction in surface mass balance since about 1995 can be attributed largely to a coincident trend of decreasing summer cloud cover enhancing the melt-albedo feedback. Satellite observations show that, from 1995 to 2009, summer cloud cover decreased by 0.9 ± 0.3% per year. Model output indicates that the GrIS summer melt increases by 27 ± 13 gigatons (Gt) per percent reduction in summer cloud cover, principally because of the impact of increased shortwave radiation over the low albedo ablation zone. The observed reduction in cloud cover is strongly correlated with a state shift in the North Atlantic Oscillation promoting anticyclonic conditions in summer and suggests that the enhanced surface mass loss from the GrIS is driven by synoptic-scale changes in Arctic-wide atmospheric circulation.

  15. Fasting Ghrelin Levels Are Decreased in Obese Subjects and Are Significantly Related With Insulin Resistance and Body Mass Index

    Directory of Open Access Journals (Sweden)

    Dimitrios Papandreou

    2017-10-01

    CONCLUSION: Obese subjects have low fasting ghrelin levels that they are significantly related to insulin resistance and body mass index. More prospective studies are needed to establish the role of ghrelin in the pathogenesis of human obesity.

  16. Unprecedented Mass Bleaching and Loss of Coral across 12° of Latitude in Western Australia in 2010–11

    Science.gov (United States)

    Moore, James A. Y.; Bellchambers, Lynda M.; Depczynski, Martial R.; Evans, Richard D.; Evans, Scott N.; Field, Stuart N.; Friedman, Kim J.; Gilmour, James P.; Holmes, Thomas H.; Middlebrook, Rachael; Radford, Ben T.; Ridgway, Tyrone; Shedrawi, George; Taylor, Heather; Thomson, Damian P.; Wilson, Shaun K.

    2012-01-01

    Background Globally, coral bleaching has been responsible for a significant decline in both coral cover and diversity over the past two decades. During the summer of 2010–11, anomalous large-scale ocean warming induced unprecedented levels of coral bleaching accompanied by substantial storminess across more than 12° of latitude and 1200 kilometers of coastline in Western Australia (WA). Methodology/Principal Findings Extreme La-Niña conditions caused extensive warming of waters and drove considerable storminess and cyclonic activity across WA from October 2010 to May 2011. Satellite-derived sea surface temperature measurements recorded anomalies of up to 5°C above long-term averages. Benthic surveys quantified the extent of bleaching at 10 locations across four regions from tropical to temperate waters. Bleaching was recorded in all locations across regions and ranged between 17% (±5.5) in the temperate Perth region, to 95% (±3.5) in the Exmouth Gulf of the tropical Ningaloo region. Coincident with high levels of bleaching, three cyclones passed in close proximity to study locations around the time of peak temperatures. Follow-up surveys revealed spatial heterogeneity in coral cover change with four of ten locations recording significant loss of coral cover. Relative decreases ranged between 22%–83.9% of total coral cover, with the greatest losses in the Exmouth Gulf. Conclusions/Significance The anomalous thermal stress of 2010–11 induced mass bleaching of corals along central and southern WA coral reefs. Significant coral bleaching was observed at multiple locations across the tropical-temperate divide spanning more than 1200 km of coastline. Resultant spatially patchy loss of coral cover under widespread and high levels of bleaching and cyclonic activity, suggests a degree of resilience for WA coral communities. However, the spatial extent of bleaching casts some doubt over hypotheses suggesting that future impacts to coral reefs under forecast

  17. Resource loss as a predictor of posttrauma symptoms among college women following the mass shooting at Virginia Tech.

    Science.gov (United States)

    Littleton, Heather; Grills-Taquechel, Amie; Axsom, Danny

    2009-01-01

    We examined risk factors for posttrauma symptomatology, 2 and 6 months following the April 2007 mass shooting at Virginia Tech. Using a conservation of resources framework and a Web-based survey methodology, we prospectively evaluated the relations among preshooting distress, social support, resource loss, and posttrauma symptomatology in a sample of 293 female students enrolled at the university at the time of the shootings. Structural equation modeling supported that preshooting social support and distress predicted resource loss postshooting. Resource loss predicted symptomatology 2 months and 6 months after the shooting. Implications of the results for research and intervention following mass trauma are discussed.

  18. Carbon input belowground is the major C flux contributing to leaf litter mass loss

    DEFF Research Database (Denmark)

    Rubino, Mauro; Dungait; Evershed

    2010-01-01

    and analysed for their total C and 13C content. Gas chromatography (GC), GC–mass spectrometry (MS) and GC-combustion-isotope ratio (GC/C/IRMS) were used to analyse phospholipid fatty acids (PLFA) extracted from soil samples to identify the groups of soil micro-organisms that had incorporated litter-derived C...... and to determine the quantity of C incorporated by the soil microbial biomass (SMB). By the end of the experiment, the litter had lost about 80% of its original weight. The fraction of litter C lost as an input into the soil (67 ± 12% of the total C loss) was found to be twice as much as the fraction released...

  19. Volcanic eruptions on Io - Implications for surface evolution and mass loss

    Science.gov (United States)

    Johnson, T. V.; Soderblom, L. A.

    1982-01-01

    Active volcanism on Io results in a continual resurfacing of the satellite. Analysis of required burial rates to erase impact craters, the mass production in the observed plumes, and the energy requirements for the volcanic activity suggest resurfacing rates of 0.001 to 10 cm/yr in recent geologic time. If this rate is typical of the last 4.5 Gyr, then extensive recycling of the upper crust and mantle must have occurred. The currently estimated loss rate of S, O, and Na from Io into the magnetosphere corresponds to only a small fraction of the resurfacing rate and should not have resulted in either extensive erosion or total depletion of any of the escaping species.

  20. Clinically significant and sustained weight loss is achievable in obese women with polycystic ovary syndrome followed in a regular medical practice.

    Science.gov (United States)

    Pelletier, Lysanne; Baillargeon, Jean-Patrice

    2010-12-01

    To determine the proportion of obese women with polycystic ovary syndrome (PCOS) losing clinically significant amounts of weight during a standard follow-up by an endocrinologist. Retrospective cohort study. Reproductive Endocrinology Clinic of an academic center. Obese patients with PCOS assessed between May 2002 and September 2008. General nonstandardized advice on weight loss and exercise. Proportion of women losing ≥5% or ≥10% of their initial weight at each of the following time interval: 2-6 months, 6-12 months, 12-18 months, 18-24 months, 24-36 months, and beyond 36 months. One hundred seventeen patients with PCOS and with a mean body mass index (BMI) of 38.7 kg/m(2) and mean age of 28.5 years were followed-up for a median duration of 21.9 months (range, 2.0-61.8 months), with a median of two visits per year. More than 40% of these women lost ≥5% of their initial weight after >6 months of follow-up, and ≥20% lost ≥10% after 1 year of follow-up. More important, these proportions were maintained up to ≥3 years. It is possible for obese women with PCOS to achieve clinically significant and sustained weight loss by following simple advices given in a regular clinical care setting. Therefore, practitioners should not underestimate their impact to facilitate weight loss in women with PCOS. Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  1. Spatial pattern of mass loss processes across the Greenland Ice Sheet from the Little Ice Age to 2010

    DEFF Research Database (Denmark)

    Kjaer, K. H.; Korsgaard, N. J.; Kjeldsen, K. K.

    The Greenland Ice Sheet loses mass through surface meltwater runoff and discharge from marine terminating outlet glaciers. The spatial variability and magnitude of these processes have been studied and described in detail for the past decades. Here, we combine the mass loss between the LIA to 2010...... these components are variable between the different sectors of the GrIS, e.g. in the southeast sector of the GrIS we find substantial mass loss, possibly driven by high precipitation rates but also the presence of a large number of marine terminating glaciers. Furthermore many areas currently undergoing changes...

  2. The Secret Lives of Cepheids: Evolution, Mass-Loss, and Ultraviolet Emission of the Long-period Classical Cepheid

    Science.gov (United States)

    Neilson, Hilding R.; Engle, Scott G.; Guinan, Edward F.; Bisol, Alexandra C.; Butterworth, Neil

    2016-06-01

    The classical Cepheid l Carinae is an essential calibrator of the Cepheid Leavitt Law as a rare long-period Galactic Cepheid. Understanding the properties of this star will also constrain the physics and evolution of massive (M ≥ 8 M ⊙) Cepheids. The challenge, however, is precisely measuring the star's pulsation period and its rate of period change. The former is important for calibrating the Leavitt Law and the latter for stellar evolution modeling. In this work, we combine previous time-series observations spanning more than a century with new observations to remeasure the pulsation period and compute the rate of period change. We compare our new rate of period change with stellar evolution models to measure the properties of l Car, but find models and observations are, at best, marginally consistent. The results imply that l Car does not have significantly enhanced mass-loss rates like that measured for δ Cephei. We find that the mass of l Car is about 8-10 M ⊙. We present Hubble Space Telescope Cosmic Origins Spectrograph observations that also differ from measurements for δ Cep and β Dor. These measurements further add to the challenge of understanding the physics of Cepheids, but do hint at the possible relation between enhanced mass-loss and ultraviolet emission, perhaps both due to the strength of shocks propagating in the atmospheres of Cepheids. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. These observations are associated with program #13019. This work is also based on observations obtained with XMM-Newton, an ESA science mission with instruments and contributions directly funded by ESA Member States and the USA (NASA), associated with program #060374.

  3. Time-Course of Muscle Mass Loss, Damage, and Proteolysis in Gastrocnemius following Unloading and Reloading: Implications in Chronic Diseases

    Science.gov (United States)

    Chacon-Cabrera, Alba; Lund-Palau, Helena; Gea, Joaquim; Barreiro, Esther

    2016-01-01

    Background Disuse muscle atrophy is a major comorbidity in patients with chronic diseases including cancer. We sought to explore the kinetics of molecular mechanisms shown to be involved in muscle mass loss throughout time in a mouse model of disuse muscle atrophy and recovery following immobilization. Methods Body and muscle weights, grip strength, muscle phenotype (fiber type composition and morphometry and muscle structural alterations), proteolysis, contractile proteins, systemic troponin I, and mitochondrial content were assessed in gastrocnemius of mice exposed to periods (1, 2, 3, 7, 15 and 30 days) of non-invasive hindlimb immobilization (plastic splint, I cohorts) and in those exposed to reloading for different time-points (1, 3, 7, 15, and 30 days, R cohorts) following a seven-day period of immobilization. Groups of control animals were also used. Results Compared to non-exposed controls, muscle weight, limb strength, slow- and fast-twitch cross-sectional areas, mtDNA/nDNA, and myosin content were decreased in mice of I cohorts, whereas tyrosine release, ubiquitin-proteasome activity, muscle injury and systemic troponin I levels were increased. Gastrocnemius reloading following splint removal improved muscle mass loss, strength, fiber atrophy, injury, myosin content, and mtDNA/nDNA, while reducing ubiquitin-proteasome activity and proteolysis. Conclusions A consistent program of molecular and cellular events leading to reduced gastrocnemius muscle mass and mitochondrial content and reduced strength, enhanced proteolysis, and injury, was seen in this non-invasive mouse model of disuse muscle atrophy. Unloading of the muscle following removal of the splint significantly improved the alterations seen during unloading, characterized by a specific kinetic profile of molecular events involved in muscle regeneration. These findings have implications in patients with chronic diseases including cancer in whom physical activity may be severely compromised. PMID

  4. Contributions of natural and anthropogenic radiative forcing to mass loss of Northern Hemisphere mountain glaciers and quantifying their uncertainties.

    Science.gov (United States)

    Hirabayashi, Yukiko; Nakano, Kazunari; Zhang, Yong; Watanabe, Satoshi; Tanoue, Masahiro; Kanae, Shinjiro

    2016-07-20

    Observational evidence indicates that a number of glaciers have lost mass in the past. Given that glaciers are highly impacted by the surrounding climate, human-influenced global warming may be partly responsible for mass loss. However, previous research studies have been limited to analyzing the past several decades, and it remains unclear whether past glacier mass losses are within the range of natural internal climate variability. Here, we apply an optimal fingerprinting technique to observed and reconstructed mass losses as well as multi-model general circulation model (GCM) simulations of mountain glacier mass to detect and attribute past glacier mass changes. An 8,800-year control simulation of glaciers enabled us to evaluate detectability. The results indicate that human-induced increases in greenhouse gases have contributed to the decreased area-weighted average masses of 85 analyzed glaciers. The effect was larger than the mass increase caused by natural forcing, although the contributions of natural and anthropogenic forcing to decreases in mass varied at the local scale. We also showed that the detection of anthropogenic or natural influences could not be fully attributed when natural internal climate variability was taken into account.

  5. Contributions of natural and anthropogenic radiative forcing to mass loss of Northern Hemisphere mountain glaciers and quantifying their uncertainties

    Science.gov (United States)

    Hirabayashi, Yukiko; Nakano, Kazunari; Zhang, Yong; Watanabe, Satoshi; Tanoue, Masahiro; Kanae, Shinjiro

    2016-07-01

    Observational evidence indicates that a number of glaciers have lost mass in the past. Given that glaciers are highly impacted by the surrounding climate, human-influenced global warming may be partly responsible for mass loss. However, previous research studies have been limited to analyzing the past several decades, and it remains unclear whether past glacier mass losses are within the range of natural internal climate variability. Here, we apply an optimal fingerprinting technique to observed and reconstructed mass losses as well as multi-model general circulation model (GCM) simulations of mountain glacier mass to detect and attribute past glacier mass changes. An 8,800-year control simulation of glaciers enabled us to evaluate detectability. The results indicate that human-induced increases in greenhouse gases have contributed to the decreased area-weighted average masses of 85 analyzed glaciers. The effect was larger than the mass increase caused by natural forcing, although the contributions of natural and anthropogenic forcing to decreases in mass varied at the local scale. We also showed that the detection of anthropogenic or natural influences could not be fully attributed when natural internal climate variability was taken into account.

  6. Deviation from goal pace, body temperature and body mass loss as predictors of road race performance.

    Science.gov (United States)

    Adams, William M; Hosokawa, Yuri; Belval, Luke N; Huggins, Robert A; Stearns, Rebecca L; Casa, Douglas J

    2017-03-01

    The purpose of this study was to examine the relationship between pacing, gastrointestinal temperature (T GI ), and percent body mass loss (%BML) on relative race performance during a warm weather 11.3km road race. Observational study of a sample of active runners competing in the 2014 Falmouth Road Race. Participants ingested a T GI pill and donned a GPS enabled watch with heart rate monitoring capabilities prior to the start of the race. Percent off predicted pace (% OFF ) was calculated for seven segments of the race. Separate linear regression analyses were used to assess the relationship between pace, T ​GI , and %BML on relative race performance. One-way ANOVA was used to analyse post race T GI (≥40°C vs 0.05). There was a trend in a slower pace (p=0.055) and greater % OFF (p=0.056) in runners finishing the race with a T GI >40°C. Overall, finish time was influenced by greater variations in pace during the first two miles of the race. In addition, runners who minimized fluid losses and had lower T GI were associated with meeting self-predicted goals. Copyright © 2016 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  7. Unprecedented mass bleaching and loss of coral across 12° of latitude in Western Australia in 2010-11.

    Science.gov (United States)

    Moore, James A Y; Bellchambers, Lynda M; Depczynski, Martial R; Evans, Richard D; Evans, Scott N; Field, Stuart N; Friedman, Kim J; Gilmour, James P; Holmes, Thomas H; Middlebrook, Rachael; Radford, Ben T; Ridgway, Tyrone; Shedrawi, George; Taylor, Heather; Thomson, Damian P; Wilson, Shaun K

    2012-01-01

    Globally, coral bleaching has been responsible for a significant decline in both coral cover and diversity over the past two decades. During the summer of 2010-11, anomalous large-scale ocean warming induced unprecedented levels of coral bleaching accompanied by substantial storminess across more than 12° of latitude and 1200 kilometers of coastline in Western Australia (WA). Extreme La-Niña conditions caused extensive warming of waters and drove considerable storminess and cyclonic activity across WA from October 2010 to May 2011. Satellite-derived sea surface temperature measurements recorded anomalies of up to 5°C above long-term averages. Benthic surveys quantified the extent of bleaching at 10 locations across four regions from tropical to temperate waters. Bleaching was recorded in all locations across regions and ranged between 17% (±5.5) in the temperate Perth region, to 95% (±3.5) in the Exmouth Gulf of the tropical Ningaloo region. Coincident with high levels of bleaching, three cyclones passed in close proximity to study locations around the time of peak temperatures. Follow-up surveys revealed spatial heterogeneity in coral cover change with four of ten locations recording significant loss of coral cover. Relative decreases ranged between 22%-83.9% of total coral cover, with the greatest losses in the Exmouth Gulf. The anomalous thermal stress of 2010-11 induced mass bleaching of corals along central and southern WA coral reefs. Significant coral bleaching was observed at multiple locations across the tropical-temperate divide spanning more than 1200 km of coastline. Resultant spatially patchy loss of coral cover under widespread and high levels of bleaching and cyclonic activity, suggests a degree of resilience for WA coral communities. However, the spatial extent of bleaching casts some doubt over hypotheses suggesting that future impacts to coral reefs under forecast warming regimes may in part be mitigated by southern thermal refugia.

  8. Tidal heating and mass loss in neutron star binaries - Implications for gamma-ray burst models

    Science.gov (United States)

    Meszaros, P.; Rees, M. J.

    1992-01-01

    A neutron star in a close binary orbit around another neutron star (or stellar-mass black hole) spirals inward owing to gravitational radiation. We discuss the effects of tidal dissipation during this process. Tidal energy dissipated in the neutron star's core escapes mainly as neutrinos, but heating of the crust, and outward diffusion of photons, blows off the outer layers of the star. This photon-driven mass loss precedes the final coalescence. The presence of this eject material impedes the escape of gamma-rays created via neutrino interactions. If an e(+) - e(-) fireball, created in the late stages of coalescence, were loaded with (or surrounded by) material with the mean column density of the ejecta, it could not be an efficient source of gamma-rays. Models for cosmologically distant gamma-rays burst that involve neutron stars must therefore be anisotropic, so that the fireball expands preferentially in directions where the column density of previously blown-off material is far below the spherically averaged value which we have calculated. Some possible 'scenarios' along these lines are briefly discussed.

  9. The Impact of Atmospheric Modeling Errors on GRACE Estimates of Mass Loss in Greenland and Antarctica

    Science.gov (United States)

    Hardy, Ryan A.; Nerem, R. Steven; Wiese, David N.

    2017-12-01

    Systematic errors in Gravity Recovery and Climate Experiment (GRACE) monthly mass estimates over the Greenland and Antarctic ice sheets can originate from low-frequency biases in the European Centre for Medium-Range Weather Forecasts (ECMWF) Operational Analysis model, the atmospheric component of the Atmospheric and Ocean Dealising Level-1B (AOD1B) product used to forward model atmospheric and ocean gravity signals in GRACE processing. These biases are revealed in differences in surface pressure between the ECMWF Operational Analysis model, state-of-the-art reanalyses, and in situ surface pressure measurements. While some of these errors are attributable to well-understood discrete model changes and have published corrections, we examine errors these corrections do not address. We compare multiple models and in situ data in Antarctica and Greenland to determine which models have the most skill relative to monthly averages of the dealiasing model. We also evaluate linear combinations of these models and synthetic pressure fields generated from direct interpolation of pressure observations. These models consistently reveal drifts in the dealiasing model that cause the acceleration of Antarctica's mass loss between April 2002 and August 2016 to be underestimated by approximately 4 Gt yr-2. We find similar results after attempting to solve the inverse problem, recovering pressure biases directly from the GRACE Jet Propulsion Laboratory RL05.1 M mascon solutions. Over Greenland, we find a 2 Gt yr-1 bias in mass trend. While our analysis focuses on errors in Release 05 of AOD1B, we also evaluate the new AOD1B RL06 product. We find that this new product mitigates some of the aforementioned biases.

  10. Greenland Ice Sheet Surface Temperature, Melt, and Mass Loss: 2000-2006

    Science.gov (United States)

    Hall, Dorothy K.; Williams, Richard S., Jr.; Luthcke, Scott B.; DiGirolamo, Nocolo

    2007-01-01

    Extensive melt on the Greenland Ice Sheet has been documented by a variety of ground and satellite measurements in recent years. If the well-documented warming continues in the Arctic, melting of the Greenland Ice Sheet will likely accelerate, contributing to sea-level rise. Modeling studies indicate that an annual or summer temperature rise of 1 C on the ice sheet will increase melt by 20-50% therefore, surface temperature is one of the most important ice-sheet parameters to study for analysis of changes in the mass balance of the ice-sheet. The Greenland Ice Sheet contains enough water to produce a rise in eustatic sea level of up to 7.0 m if the ice were to melt completely. However, even small changes (centimeters) in sea level would cause important economic and societal consequences in the world's major coastal cities thus it is extremely important to monitor changes in the ice-sheet surface temperature and to ultimately quantify these changes in terms of amount of sea-level rise. We have compiled a high-resolution, daily time series of surface temperature of the Greenland Ice Sheet, using the I-km resolution, clear-sky land-surface temperature (LST) standard product from the Moderate-Resolution Imaging Spectroradiometer (MODIS), from 2000 - 2006. We also use Gravity Recovery and Climate Experiment (GRACE) data, averaged over 10-day periods, to measure change in mass of the ice sheet as it melt and snow accumulates. Surface temperature can be used to determine frequency of surface melt, timing of the start and the end of the melt season, and duration of melt. In conjunction with GRACE data, it can also be used to analyze timing of ice-sheet mass loss and gain.

  11. Significance of computed tomography in the diagnosis of the mediastinal mass lesions

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, Masanori; Takashima, Tsutomu; Suzuki, Masayuki; Itoh, Hiroshi; Hirose, Jinichiro; Choto, Shuichi (Kanazawa Univ. (Japan). School of Medicine)

    1983-08-01

    Thirty cases of the mediastinal mass lesions were examined by computed tomography and diagnostic ability of CT was retrospectively evaluated. We devided them into two major groups: cystic and solid lesions. Cysts and cystic teratomas were differentiated on the thickness of their wall. Pericardial cysts were typically present at the cardiophrenic angle. In the solid mediastinal lesions, the presence of calcific and/or fatty components, the presence of necrosis, the irregularity of the margin and the obliteration of the surrounding fat layer were the clues to differential diagnosis and of evaluation for their invasiveness. Although differential diagnosis of the solid anterior mediastinal tumors was often difficult, teratomas with calcific and fatty componets were easily diagnosed. Invasiveness of the malignant thymoma and other malignant lesions were successfully evaluated to some extent. Neurogenic posterior mediastinal tumors were easily diagnosed because of the presence of the spine deformity and typical dumbbell shaped appearance. We stress that our diagnostic approach is useful to differentiate the mediastinal mass lesions.

  12. Significance of computed tomography in the diagnosis of the mediastinal mass lesions

    International Nuclear Information System (INIS)

    Kimura, Masanori; Takashima, Tsutomu; Suzuki, Masayuki; Itoh, Hiroshi; Hirose, Jinichiro; Choto, Shuichi

    1983-01-01

    Thirty cases of the mediastinal mass lesions were examined by computed tomography and diagnostic ability of CT was retrospectively evaluated. We devided them into two major groups: cystic and solid lesions. Cysts and cystic teratomas were differentiated on the thickness of their wall. Pericardial cysts were typically present at the cardiophrenic angle. In the solid mediastinal lesions, the presence of calcific and/or fatty components, the presence of necrosis, the irregularity of the margin and the obliteration of the surrounding fat layer were the clues to differential diagnosis and of evaluation for their invasiveness. Although differential diagnosis of the solid anterior mediastinal tumors was often difficult, teratomas with calcific and fatty componets were easily diagnosed. Invasiveness of the malignant thymoma and other malignant lesions were successfully evaluated to some extent. Neurogenic posterior mediastinal tumors were easily diagnosed because of the presence of the spine deformity and typical dumbbell shaped appearance. We stress that our diagnostic approach is useful to differentiate the mediastinal mass lesions. (author)

  13. The Significance of Witness Sensors for Mass Casualty Incidents and Epidemic Outbreaks.

    Science.gov (United States)

    Pan, Chih-Long; Lin, Chih-Hao; Lin, Yan-Ren; Wen, Hsin-Yu; Wen, Jet-Chau

    2018-02-02

    Due to the increasing number of natural and man-made disasters, mass casualty incidents occur more often than ever before. As a result, health care providers need to adapt in order to cope with the overwhelming patient surge. To ensure quality and safety in health care, accurate information in pandemic disease control, death reduction, and health quality promotion should be highlighted. However, obtaining precise information in real time is an enormous challenge to all researchers of the field. In this paper, innovative strategies are presented to develop a sound information network using the concept of "witness sensors." To overcome the reliability and quality limitations of information obtained through social media, researchers must focus on developing solutions that secure the authenticity of social media messages, especially for matters related to health. To address this challenge, we introduce a novel concept based on the two elements of "witness" and "sensor." Witness sensors can be key players designated to minimize limitations to quality of information and to distinguish fact from fiction during critical events. In order to enhance health communication practices and deliver valid information to end users, the education and management of witness sensors should be further investigated, especially for implementation during mass casualty incidents and epidemic outbreaks. ©Chih-Long Pan, Chih-Hao Lin, Yan-Ren Lin, Hsin-Yu Wen, Jet-Chau Wen. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 02.02.2018.

  14. Role of protein and amino acids in promoting lean mass accretion with resistance exercise and attenuating lean mass loss during energy deficit in humans.

    Science.gov (United States)

    Churchward-Venne, Tyler A; Murphy, Caoileann H; Longland, Thomas M; Phillips, Stuart M

    2013-08-01

    Amino acids are major nutrient regulators of muscle protein turnover. After protein ingestion, hyperaminoacidemia stimulates increased rates of skeletal muscle protein synthesis, suppresses muscle protein breakdown, and promotes net muscle protein accretion for several hours. These acute observations form the basis for strategized protein intake to promote lean mass accretion, or prevent lean mass loss over the long term. However, factors such as protein dose, protein source, and timing of intake are important in mediating the anabolic effects of amino acids on skeletal muscle and must be considered within the context of evaluating the reported efficacy of long-term studies investigating protein supplementation as part of a dietary strategy to promote lean mass accretion and/or prevent lean mass loss. Current research suggests that dietary protein supplementation can augment resistance exercise-mediated gains in skeletal muscle mass and strength and can preserve skeletal muscle mass during periods of diet-induced energy restriction. Perhaps less appreciated, protein supplementation can augment resistance training-mediated gains in skeletal muscle mass even in individuals habitually consuming 'adequate' (i.e., >0.8 g kg⁻¹ day⁻¹) protein. Additionally, overfeeding energy with moderate to high-protein intake (15-25 % protein or 1.8-3.0 g kg⁻¹ day⁻¹) is associated with lean, but not fat mass accretion, when compared to overfeeding energy with low protein intake (5 % protein or ~0.68 g kg⁻¹ day⁻¹). Amino acids represent primary nutrient regulators of skeletal muscle anabolism, capable of enhancing lean mass accretion with resistance exercise and attenuating the loss of lean mass during periods of energy deficit, although factors such as protein dose, protein source, and timing of intake are likely important in mediating these effects.

  15. Uncovering biologically significant lipid isomers with liquid chromatography, ion mobility spectrometry and mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Kyle, Jennifer E.; Zhang, Xing; Weitz, Karl K.; Monroe, Matthew E.; Ibrahim, Yehia M.; Moore, Ronald J.; Cha, Jeeyeon; Sun, Xiaofei; Lovelace, Erica S.; Wagoner, Jessica; Polyak, Steve; Metz, Thomas O.; Dey, Sudhansu K.; Smith, Richard D.; Burnum-Johnson, Kristin E.; Baker, Erin Shammel

    2016-01-01

    Understanding how biological molecules are generated, metabolized and eliminated in living systems is important for interpreting processes such as immune response and disease pathology. While genomic and proteomic studies have provided vast amounts of information over the last several decades, interest in lipidomics has also grown due to improved analytical technologies revealing altered lipid metabolism in type 2 diabetes, cancer, and lipid storage disease. Liquid chromatography and mass spectrometry (LC-MS) measurements are currently the dominant approach for characterizing the lipidome by providing detailed information on the spatial and temporal composition of lipids. However, interpreting lipids’ biological roles is challenging due to the existence of numerous structural and stereoisomers (i.e. distinct acyl chain and double-bond positions), which are unresolvable using present LC-MS approaches. Here we show that combining structurally-based ion mobility spectrometry (IMS) with LC-MS measurements distinguishes lipid isomers and allows insight into biological and disease processes.

  16. ACUTE EFFECTS OF SELF-SELECTED REGIMEN OF RAPID BODY MASS LOSS IN COMBAT SPORTS ATHLETES

    Directory of Open Access Journals (Sweden)

    Jaan Ereline

    2008-06-01

    Full Text Available The purpose of the study was to assess the acute effects of the self-selected regimen of rapid body mass loss (RBML on muscle performance and metabolic response to exercise in combat sports athletes. Seventeen male athletes (20.8 ± 1.0 years; mean ± SD reduced their body mass by 5.1 ± 1.1% within 3 days. The RBML was achieved by a gradual reduction of energy and fluid intake and mild sauna procedures. A battery of tests was performed before (Test 1 and immediately after (Test 2 RBML. The test battery included the measurement of the peak torque of knee extensors for three different speeds, assessment of total work (Wtot performed during a 3-min intermittent intensity knee extension exercise and measurements of blood metabolites (ammonia, lactate, glucose and urea. Absolute peak torque was lower in Test 2 compared with Test 1 at angular velocities of 1.57 rad·s-1 (218.6 ± 40.9 vs. 234.4 ± 42.2 N·m; p = 0.013 and 3.14 rad·s-1 (100.3 ± 27.8 vs. 111.7 ± 26.2 N·m; p = 0.008. The peak torque in relation to body mass remained unchanged for any speed. Absolute Wtot was lower in Test 2 compared with Test 1 (6359 ± 2326 vs. 7452 ± 3080 J; p = 0.003 as well as Wtot in relation to body mass (89.1 ± 29.9 vs. 98.6 ± 36.4 J·kg-1; p = 0.034, respectively. As a result of RBML, plasma urea concentration increased from 4.9 to 5.9 mmol·l-1 (p = 0.003. The concentration of ammonia in a post-test sample in Test 2 tended to be higher in comparison with Test 1 (80.9 ± 29.1 vs. 67.6 ± 26.5 mmol·l-1; p = 0.082. The plasma lactate and glucose responses to exercise were similar in Test 1 and Test 2. We conclude that the self-selected regimen of RBML impairs muscle performance in 3-min intermittent intensity exercise and induces an increase in blood urea concentration in experienced male combat sports athletes

  17. Modeling of Camembert-type cheese mass loss in a ripening chamber: main biological and physical phenomena.

    Science.gov (United States)

    Hélias, A; Mirade, P-S; Corrieu, G

    2007-11-01

    A model of the mass loss of Camembert-type cheese was established with data obtained from 2 experimental ripening trials carried out in 2 pilot ripening chambers. During these experiments, a cheese was continuously weighed and the relative humidity, temperature, oxygen, and carbon dioxide concentrations in the ripening chamber were recorded online. The aim was to establish a simple but accurate model that would predict cheese mass changes according to available online measurements. The main hypotheses were that 1) the cheese water activity was constant during ripening, 2) the respiratory activity of the microflora played a major role by inducing heat production, combined with important water evaporation, 3) the temperature gradient existing inside the cheese was negligible, and the limiting phenomenon was the convective transfer. The water activity and the specific heat of the cheeses were assessed by offline measurements. The others parameters in the model were obtained from the literature. This dynamic model was built with 2 state variables: the cheese mass and the surface temperature of the cheese. In this way, only the heat transfer coefficient had to be fitted, and it was strongly determined by the airflow characteristics close to the cheeses. Model efficiency was illustrated by comparing the estimated and measured mass and the mass loss rate for the 2 studied runs; the relative errors were less than 1.9 and 3.2% for the mass loss and the mass loss rate, respectively. The dynamic effects of special events, such as room defrosting or changes in chamber relative humidity, were well described by the model, especially in terms of kinetics (mass loss rates).

  18. Increased Body Mass Index during Therapy for Childhood Acute Lymphoblastic Leukemia: A Significant and Underestimated Complication

    Directory of Open Access Journals (Sweden)

    Helen C. Atkinson

    2015-01-01

    Full Text Available Objective & Design. We undertook a retrospective review of children diagnosed with acute lymphoblastic leukemia (ALL and treated with modern COG protocols (n=80 to determine longitudinal changes in body mass index (BMI and the prevalence of obesity compared with a healthy reference population. Results. At diagnosis, the majority of patients (77.5% were in the healthy weight category. During treatment, increases in BMI z-scores were greater for females than males; the prevalence of obesity increased from 10.3% to 44.8% (P<0.004 for females but remained relatively unchanged for males (9.8% to 13.7%, P=0.7. Longitudinal analysis using linear mixed-effects identified associations between BMI z-scores and time-dependent interactions with sex (P=0.0005, disease risk (P<0.0001, age (P=0.0001, and BMI z-score (P<0.0001 at diagnosis and total dose of steroid during maintenance (P=0.01. Predicted mean BMI z-scores at the end of therapy were greater for females with standard risk ALL irrespective of age at diagnosis and for males younger than 4 years of age at diagnosis with standard risk ALL. Conclusion. Females treated on standard risk protocols and younger males may be at greatest risk of becoming obese during treatment for ALL. These subgroups may benefit from intervention strategies to manage BMI during treatment for ALL.

  19. FUNDAMENTAL PARAMETERS, INTEGRATED RED GIANT BRANCH MASS LOSS, AND DUST PRODUCTION IN THE GALACTIC GLOBULAR CLUSTER 47 TUCANAE

    International Nuclear Information System (INIS)

    McDonald, I.; Zijlstra, A. A.; Boyer, M. L.; Gordon, K.; Meixner, M.; Sewilo, M.; Shiao, B.; Whitney, B.; Van Loon, J. Th.; Hora, J. L.; Robitaille, T.; Babler, B.; Meade, M.; Block, M.; Misselt, K.

    2011-01-01

    Fundamental parameters and time evolution of mass loss are investigated for post-main-sequence stars in the Galactic globular cluster 47 Tucanae (NGC 104). This is accomplished by fitting spectral energy distributions (SEDs) to existing optical and infrared photometry and spectroscopy, to produce a true Hertzsprung-Russell diagram. We confirm the cluster's distance as d = 4611 +213 -200 pc and age as 12 ± 1 Gyr. Horizontal branch models appear to confirm that no more red giant branch mass loss occurs in 47 Tuc than in the more metal-poor ω Centauri, though difficulties arise due to inconsistencies between the models. Using our SEDs, we identify those stars that exhibit infrared excess, finding excess only among the brightest giants: dusty mass loss begins at a luminosity of ∼1000 L sun , becoming ubiquitous above L = 2000 L sun . Recent claims of dust production around lower-luminosity giants cannot be reproduced, despite using the same archival Spitzer imagery.

  20. Suppressed Far-UV Stellar Activity and Low Planetary Mass Loss in the WASP-18 System

    Science.gov (United States)

    Fossati, L.; Koskinen, T.; France, K.; Cubillos, P. E.; Haswell, C. A.; Lanza, A. F.; Pillitteri, I.

    2018-03-01

    WASP-18 hosts a massive, very close-in Jupiter-like planet. Despite its young age (extinction (E(B-V) ≈ 0.01 mag) and then the interstellar medium (ISM) column density for a number of ions, concluding that ISM absorption is not the origin of the anomaly. We measure the flux of the four stellar emission features detected in the COS spectrum (C II, C III, C IV, Si IV). Comparing the C II/C IV flux ratio measured for WASP-18 with that derived from spectra of nearby stars with known age, we see that the far-UV spectrum of WASP-18 resembles that of old (>5 Gyr), inactive stars, in stark contrast with its young age. We conclude that WASP-18 has an intrinsically low activity level, possibly caused by star–planet tidal interaction, as suggested by previous studies. Re-scaling the solar irradiance reference spectrum to match the flux of the Si IV line, yields an XUV integrated flux at the planet orbit of 10.2 erg s‑1 cm‑2. We employ the rescaled XUV solar fluxes to models of the planetary upper atmosphere, deriving an extremely low thermal mass-loss rate of 10‑20 M J Gyr‑1. For such high-mass planets, thermal escape is not energy limited, but driven by Jeans escape. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained from MAST at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. These observations are associated with program #13859. Based on observations made with ESO Telescopes at the La Silla Paranal Observatory under programme ID 092.D-0587.

  1. Changes in fat-free mass in obese subjects after weight loss : a comparison of body composition measures

    NARCIS (Netherlands)

    van der Kooy, K; Leenen, R; Deurenberg, P.; Seidell, J C; Westerterp, K R; Hautvast, J.G.A.J.

    Estimates of body composition by densitometry were made in 84 apparently healthy subjects (42 men, 42 women) with a mean age of 40 +/- 6 years (mean +/- s.d.), before and after weight loss. The initial body mass index (BMI) was 30.7 +/- 2.3 kg/m2 and the achieved weight loss on a 4.2 MJ/day energy

  2. How much can Greenland melt? An upper bound on mass loss from the Greenland Ice Sheet through surface melting

    Science.gov (United States)

    Liu, X.; Bassis, J. N.

    2015-12-01

    With observations showing accelerated mass loss from the Greenland Ice Sheet due to surface melt, the Greenland Ice Sheet is becoming one of the most significant contributors to sea level rise. The contribution of the Greenland Ice Sheet o sea level rise is likely to accelerate in the coming decade and centuries as atmospheric temperatures continue to rise, potentially triggering ever larger surface melt rates. However, at present considerable uncertainty remains in projecting the contribution to sea level of the Greenland Ice Sheet both due to uncertainty in atmospheric forcing and the ice sheet response to climate forcing. Here we seek an upper bound on the contribution of surface melt from the Greenland to sea level rise in the coming century using a surface energy balance model coupled to an englacial model. We use IPCC Representative Concentration Pathways (RCP8.5, RCP6, RCP4.5, RCP2.6) climate scenarios from an ensemble of global climate models in our simulations to project the maximum rate of ice volume loss and related sea-level rise associated with surface melting. To estimate the upper bound, we assume the Greenland Ice Sheet is perpetually covered in thick clouds, which maximize longwave radiation to the ice sheet. We further assume that deposition of black carbon darkens the ice substantially turning it nearly black, substantially reducing its albedo. Although assuming that all melt water not stored in the snow/firn is instantaneously transported off the ice sheet increases mass loss in the short term, refreezing of retained water warms the ice and may lead to more melt in the long term. Hence we examine both assumptions and use the scenario that leads to the most surface melt by 2100. Preliminary models results suggest that under the most aggressive climate forcing, surface melt from the Greenland Ice Sheet contributes ~1 m to sea level by the year 2100. This is a significant contribution and ignores dynamic effects. We also examined a lower bound

  3. The spatial variable glacier mass loss over the southeast Tibet Plateau and the climate cause analyses

    Science.gov (United States)

    Ke, L.; Ding, X.; Song, C.; Sheng, Y.

    2016-12-01

    Temperate glaciers can be highly sensitive to global climate change due to relatively humid and warm local climate. Numerous temperate glaciers are distributed in the southeastern Tibet Plateau (SETP) and their changes are still poorly represented. Based on a latest glacier inventory and ICESat altimetry measurements, we examine the spatial heterogeneity of glacier change in the SETP (including the central and eastern Nyainqêntanglha ranges) and further analyze its relation with climate change by using station-based and gridded meteorological data. Our results show that SETP glaciers experienced drastic surface lowering at about -0.84±0.26 m a-1 on average over 2003-2008. Debris-covered ice thinned at an average rate of -1.13±0.32 m a-1, in comparison with -0.92±0.17 m a-1 over the debris-free ice areas. The thinning rate is the strongest in the southeastern sub-region (up to -1.24 m a-1 ) and moderate ( -0.45 m a-1 ) in the central and northwestern parts, which is in general agreement with the pattern of surface mass changes based on the GRACE gravimetry observation. Long-term climate data at weather stations show that, in comparison with the period of 1992-2002, mean temperature increased by 0.46 °C - 0.59 °C in the recent decade (2003-2013); while the change of summer precipitation exhibited remarkably spatial variability, following a southeast-northwest contrasting pattern (decreasing by over 10% in the southeast, to stable level in the central region, and increment up to 10% in the northwest). This spatially variable precipitation change is consistent with results from CN05 grid data and ERA re-analysis data, and agrees well with the spatial pattern of glacier surface elevation changes. The results suggest that overall negative glacier mass balances in SETP are governed by temperature rising, while the different precipitation change could contribute to inconsistent glacier thinning rates. The spatial pattern of precipitation decrease and mass loss might

  4. Biological annihilation via the ongoing sixth mass extinction signaled by vertebrate population losses and declines.

    Science.gov (United States)

    Ceballos, Gerardo; Ehrlich, Paul R; Dirzo, Rodolfo

    2017-07-25

    The population extinction pulse we describe here shows, from a quantitative viewpoint, that Earth's sixth mass extinction is more severe than perceived when looking exclusively at species extinctions. Therefore, humanity needs to address anthropogenic population extirpation and decimation immediately. That conclusion is based on analyses of the numbers and degrees of range contraction (indicative of population shrinkage and/or population extinctions according to the International Union for Conservation of Nature) using a sample of 27,600 vertebrate species, and on a more detailed analysis documenting the population extinctions between 1900 and 2015 in 177 mammal species. We find that the rate of population loss in terrestrial vertebrates is extremely high-even in "species of low concern." In our sample, comprising nearly half of known vertebrate species, 32% (8,851/27,600) are decreasing; that is, they have decreased in population size and range. In the 177 mammals for which we have detailed data, all have lost 30% or more of their geographic ranges and more than 40% of the species have experienced severe population declines (>80% range shrinkage). Our data indicate that beyond global species extinctions Earth is experiencing a huge episode of population declines and extirpations, which will have negative cascading consequences on ecosystem functioning and services vital to sustaining civilization. We describe this as a "biological annihilation" to highlight the current magnitude of Earth's ongoing sixth major extinction event.

  5. Effects of protein supplementation on fat-free mass in response to different weight loss programs in obese women

    Directory of Open Access Journals (Sweden)

    Andiara Schwingel

    2006-09-01

    Full Text Available The aim of this study was to investigate whether protein supplementation helps prevent the loss of fat-free mass during weight loss. The sample was composed of seventy-eight obese adult Japanese women, assigned into four different programs: diet-alone (D, n=24, diet-alone with protein supplementation (DP, n=16, diet-plusexercise (DE, n=17, and diet-plus-exercise with protein supplementation (DEP, n=21. All participants restricted their energy intakes to 1200 kcal/day, and participants in DE and DEP had the exercise session including aerobic exercise of approximately 90 min/day, 3 day/week. Participants enrolled in protein supplementation groups received an additional 14 g/day of protein. Measures on body composition were conducted before and after the program by DXA. All programs yielded significant weight (6.9 to 9.5 kg and fat (4.1 to 7.6% reduction. Total fat-free mass significantly decreased in D, DP and DE groups, whereas for DEP group the decrease was not significant. Regionalfat-free mass lowered for D and DP groups in leg, arms and trunk. For those in DE group, fat-free mass in trunk was not significantly decreased, and for those in DEP group, fat-free mass in leg and trunk did not differ significantly after the program. However, no significant differences of changes in fat-free mass were observed in comparisons among all groups. Our results confirmed the efficiency of weight loss intervention on fat-mass reduction through diet and exercise. However, fat-free mass does not appear to be preserved by protein supplementation, suggesting that its influence on a short-term weight reduction program is not apparent. RESUMO O objetivo deste estudo foi investigar a influência da suplementação protéica na preservação da massa magra durante programas de emagrecimento. Setenta e oito mulheres adultas japonesas e obesas foram submetidas a quatro programas diferentes: dieta (D, n=24, dieta com suplementação proteica (DP, n=16, dieta com exerc

  6. Asteroseismology of old open clusters with Kepler: direct estimate of the integrated red giant branch mass-loss in NGC 6791 and 6819

    DEFF Research Database (Denmark)

    Miglio, A.; Brogaard, Karsten Frank; Stello, D.

    2012-01-01

    Mass-loss of red giant branch (RGB) stars is still poorly determined, despite its crucial role in the chemical enrichment of galaxies. Thanks to the recent detection of solar-like oscillations in G–K giants in open clusters with Kepler, we can now directly determine stellar masses...... for a statistically significant sample of stars in the old open clusters NGC 6791 and 6819. The aim of this work is to constrain the integrated RGB mass-loss by comparing the average mass of stars in the red clump (RC) with that of stars in the low-luminosity portion of the RGB [i.e. stars with L≲L(RC)]. Stellar...... masses were determined by combining the available seismic parameters νmax and Δν with additional photometric constraints and with independent distance estimates. We measured the masses of 40 stars on the RGB and 19 in the RC of the old metal-rich cluster NGC 6791. We find that the difference between...

  7. Significant Enhancement of Thermal Conductivity in Nanofibrillated Cellulose Films with Low Mass Fraction of Nanodiamond.

    Science.gov (United States)

    Song, Na; Cui, Siqi; Hou, Xingshuang; Ding, Peng; Shi, Liyi

    2017-11-22

    High thermal conductive nanofibrillated cellulose (NFC) hybrid films based on nanodiamond (ND) were fabricated by a facile vacuum filtration technique. In this issue, the thermal conductivity (TC) on the in-plane direction of the NFC/ND hybrid film had a significant enhancement of 775.2% at a comparatively low ND content (0.5 wt %). The NFC not only helps ND to disperse in the aqueous medium stably but also plays a positive role in the formation of the hierarchical structure. ND could form a thermal conductive pathway in the hierarchical structures under the intermolecular hydrogen bonds. Moreover, the hybrid films composed of zero-dimensional ND and one-dimensional NFC exhibit remarkable mechanical properties and optical transparency. The NFC/ND hybrid films possessing superior TC, mechanical properties, and optical transparency can open applications for portable electronic equipment as a lateral heat spreader.

  8. Measurement of spinal or peripheral bone mass to estimate early postmenopausal bone loss

    International Nuclear Information System (INIS)

    Riis, B.J.; Christiansen, C.

    1988-01-01

    This report presents data from 153 healthy, early postmenopausal women who were randomly allocated to two years of treatment with estrogen or placebo. Bone mineral content in the forearms was measured by single-photon absorptiometry, and bone mineral density of the lumbar spine and total-body bone mineral by dual-photon absorptiometry, before and after one and two years of treatment. At the end of the two years, there were highly significant differences of 6 to 7 percent between the estrogen and the placebo groups at all sites measured. The range of the changes of the spine measurement was twice that of the forearm and total-body measurements. It is concluded that measurement of the forearm by single-photon absorptiometry is superior to measurement of the spine by dual-photon absorptiometry both in clinical studies and in the individual patient for detecting estrogen-dependent bone loss and its treatment by estrogen replacement

  9. ALMA observations of anisotropic dust mass loss in the inner circumstellar environment of the red supergiant VY Canis Majoris

    Science.gov (United States)

    O'Gorman, E.; Vlemmings, W.; Richards, A. M. S.; Baudry, A.; De Beck, E.; Decin, L.; Harper, G. M.; Humphreys, E. M.; Kervella, P.; Khouri, T.; Muller, S.

    2015-01-01

    The processes leading to dust formation and the subsequent role it plays in driving mass loss in cool evolved stars is an area of intense study. Here we present high resolution ALMA Science Verification data of the continuum emission around the highly evolved oxygen-rich red supergiant VY CMa. These data enable us to study the dust in its inner circumstellar environment at a spatial resolution of 129 mas at 321 GHz and 59 mas at 658 GHz, thus allowing us to trace dust on spatial scales down to 11 R⋆ (71 AU). Two prominent dust components are detected and resolved. The brightest dust component, C, is located 334 mas (61 R⋆) southeast of the star and has a dust mass of at least 2.5 × 10-4 M⊙. It has a dust emissivity spectral index of β = -0.1 at its peak, implying that it is optically thick at these frequencies with a cool core of Td ≲ 100 K. Interestingly, not a single molecule in the ALMA data has emission close to the peak of this massive dust clump. The other main dust component, VY, is located at the position of the star and contains a total dust mass of 4.0 × 10-5 M⊙. It also contains a weaker dust feature extending over 60 R⋆ to the north with the total component having a typical dust emissivity spectral index of β = 0.7. We find that at least 17% of the dust mass around VY CMa is located in clumps ejected within a more quiescent roughly spherical stellar wind, with a quiescent dust mass loss rate of 5 × 10-6 M⊙yr-1. The anisotropic morphology of the dust indicates a continuous, directed mass loss over a few decades, suggesting that this mass loss cannot be driven by large convection cells alone. Appendices are available in electronic form at http://www.aanda.org

  10. Changes in mass loss and chemistry of AG-80 epoxy resin after 160 keV proton irradiations

    Energy Technology Data Exchange (ETDEWEB)

    Gao Yu [Space Materials and Environment Engineering Lab, Harbin Institute of Technology, Harbin, 150001 (China)]. E-mail: czq04@yahoo.com.cn; Sun Mingren [College of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150001 (China); Yang Dezhuang [Space Materials and Environment Engineering Lab, Harbin Institute of Technology, Harbin, 150001 (China); He Shiyu [Space Materials and Environment Engineering Lab, Harbin Institute of Technology, Harbin, 150001 (China); Wang Jinhe [Precision Engineering Research Institute, Harbin Institute of Technology, Harbin, 150001 (China); Xiao Jingdong [Space Materials and Environment Engineering Lab, Harbin Institute of Technology, Harbin, 150001 (China); Li Zhijun [39th Institute, China Electronic Science and Technology Groups Inc., Xi-an 710065 (China)

    2005-06-01

    The AG-80 resin is a new type of thermosetting matrix for advanced carbon/epoxy composites. Mass loss effect and the related outgassing are major concerns for its application in space. The changes in mass loss, outgassing and chemical structure under 160 keV proton exposure were investigated for the AG-80 epoxy resin. The variation in chemistry was characterized by X-ray photoelectron spectroscopy. Experimental results show that with increasing the proton fluence, the surface colour of specimens is getting darker. Mass loss ratios ascend remarkably until the fluence of approximately 5.5 x 10{sup 15} cm{sup -2}, and then tend to leveling off. The surface roughness of specimens exhibits an increasing trend followed by decreasing as a function of proton fluence. Under the exposure, the C-C, C-H, C-N and C-O bonds are broken, a variety of molecule ions with smaller molecule weight are formed, and carbon is enriched in the surface layer of specimens. The changes in mass loss and surface roughness of the AG-80 epoxy resin could be attributed to the formation of the molecule ions and the enrichment of carbon content in the surface layer due to proton radiation.

  11. ALMA observations of anisotropic dust mass loss in the inner circumstellar environment of the red supergiant VY Canis Majoris

    NARCIS (Netherlands)

    O'Gorman, E.; Vlemmings, W.; Richards, A.M.S.; Baudry, A.; De Beck, E.; Decin, L.; Harper, G.M.; Humphreys, E.M.; Kervella, P.; Khouri, T.; Muller, S.

    2015-01-01

    The processes leading to dust formation and the subsequent role it plays in driving mass loss in cool evolved stars is an area of intense study. Here we present high resolution ALMA Science Verification data of the continuum emission around the highly evolved oxygen-rich red supergiant VY CMa. These

  12. A Post-Harvest Prediction Mass Loss Model for Tomato Fruit Using A Numerical Methodology Centered on Approximation Error Minimization

    Directory of Open Access Journals (Sweden)

    Francisco Javier Bucio

    2017-10-01

    Full Text Available Due to its nutritional and economic value, the tomato is considered one of the main vegetables in terms of production and consumption in the world. For this reason, an important case study is the fruit maturation parametrized by its mass loss in this study. This process develops in the fruit mainly after harvest. Since that parameter affects the economic value of the crop, the scientific community has been progressively approaching the issue. However, there is no a state-of-the-art practical model allowing the prediction of the tomato fruit mass loss yet. This study proposes a prediction model for tomato mass loss in a continuous and definite time-frame using regression methods. The model is based on a combination of adjustment methods such as least squares polynomial regression leading to error estimation, and cross validation techniques. Experimental results from a 50 fruit of tomato sample studied over a 54 days period were compared to results from the model using a second-order polynomial approach found to provide optimal data fit with a resulting efficiency of ~97%. The model also allows the design of precise logistic strategies centered on post-harvest tomato mass loss prediction usable by producers, distributors, and consumers.

  13. Preoperative unintended weight loss and low body mass index in relation to complications and length of stay after cardiac surgery

    NARCIS (Netherlands)

    van Venrooij, Lenny M. W.; de Vos, Rien; Borgmeijer-Hoelen, Mieke M. M. J.; Haaring, Cees; de Mol, Bas A. J. M.

    Background: Several studies reported increased adverse outcomes after cardiac surgery in patients with low body mass index (BMI; in kg/m(2)). Little is known yet, however, about the effect of preoperative unintended weight loss (UWL) in cardiac surgery patients. Objective: We explored the prevalence

  14. Preoperative unintended weight loss and low body mass index in relation to complications and length of stay after cardiac surgery

    NARCIS (Netherlands)

    van Venrooij, Lenny M. W.; de Vos, Rien; Borgmeijer-Hoelen, Mieke M. M. J.; Haaring, Cees; de Mol, Bas A. J. M.

    2008-01-01

    BACKGROUND: Several studies reported increased adverse outcomes after cardiac surgery in patients with low body mass index (BMI; in kg/m(2)). Little is known yet, however, about the effect of preoperative unintended weight loss (UWL) in cardiac surgery patients. OBJECTIVE: We explored the prevalence

  15. Mass loss and flammability of insulation materials used in sandwich panels during the pre-flashover phase of fire

    NARCIS (Netherlands)

    Giunta d'Albani, A.W.; de Kluiver, L.L.; de Korte, A.C.J.; van Herpen, R.; Weewer, R.; Brouwers, H.J.H.

    2017-01-01

    Nowadays, buildings contain more and more synthetic insulation materials in order to meet the increasing energy-performance demands. These synthetic insulation materials have a different response to fire. In this study, the mass loss and flammability limits of different sandwich panels and their

  16. Controls on mass loss and nitrogen dynamics of oak leaf litter along an urban-rural land-use gradient

    Science.gov (United States)

    Richard V. Pouyat; Margaret M. Carreiro

    2003-01-01

    Using reciprocal leaf litter transplants, we investigated the effects of contrasting environments (urban vs. rural) and intraspecific variations in oak leaf litter quality on mass loss rates and nitrogen (N) dynamics along an urban-rural gradient in the New York City metropolitan area. Differences in earthworm abundances and temperature had previously been documented...

  17. Comparison of rate of En masse retraction and anchorage loss in conventional labial appliance with labial and lingual force: A clinical study

    Directory of Open Access Journals (Sweden)

    Dilshad Quraishi

    2018-01-01

    Full Text Available Aims: The rate of en masse retraction and anchorage loss were compared between labial appliance with lingual force and conventional labial appliance. Subjects and Methods: The sample consists of 14 patients and they were divided into two groups. In Group 1 – labial appliance with lingual force, elastomeric chain was placed from the palatal surface of the canines to the palatal surface of the molars. In Group 2 – labial appliance with labial force, elastomeric chain was placed from the crimpable hook distal to lateral incisor to the molar tube hooks. The rate of en masse retraction and anchorage loss was calculated for both the groups during retraction in dental casts (R0, initial; R1, 4 weeks; R2, 8 weeks; and R3, 12 weeks. Statistical Analysis Used: Student's paired t-test. Results: The rate of retraction was faster and anchorage loss was lower with labial appliance with lingual force, i.e., Group 1. The difference of anchorage loss in Group 1 and Group 2 shows t = 4.824 and P value= 0.000, which is statistically highly significant. The difference of rate of retraction in Group 1 and Group 2 shows t = 3.573 and P value = 0.004, which is statistically signifcant. Conclusions: The rate of retraction was faster and anchorage loss was lower with labial appliance with lingual force, thus indicating that this new technique of space closure utilizes biomechanical advantage of lingual force in conventional labial appliance.

  18. Macroclumping as solution of the discrepancy between Hα and P v mass loss diagnostics for O-type stars

    Science.gov (United States)

    Šurlan, B.; Hamann, W.-R.; Aret, A.; Kubát, J.; Oskinova, L. M.; Torres, A. F.

    2013-11-01

    Context. Recent studies of O-type stars have demonstrated that discrepant mass-loss rates are obtained when different diagnostic methods are employed. Fitting the unsaturated UV resonance lines (e.g., P v) gives drastically lower values than obtained from the Hα emission. Wind inhomogeneity (so-called "clumping") may be the main cause of this discrepancy. Aims: In a previous paper, we presented 3D Monte-Carlo calculations for the formation of scattering lines in a clumped stellar wind. In the present paper we select five O-type supergiants (from O4 to O7) and test whether the reported discrepancies can be resolved this way. Methods: In the first step, the analyses started with simulating the observed spectra with Potsdam Wolf-Rayet (PoWR) non-LTE model atmospheres. The mass-loss rates are adjusted to fit to the observed Hα emission lines best. For the unsaturated UV resonance lines (i.e., P v) we then applied our 3D Monte-Carlo code, which can account for wind clumps of any optical depths ("macroclumping"), a non-void interclump medium, and a velocity dispersion inside the clumps. The ionization stratifications and underlying photospheric spectra were adopted from the PoWR models. The properties of the wind clumps were constrained by fitting the observed resonance line profiles. Results: Our results show that with the mass-loss rates that fit Hα (and other Balmer and He ii lines), the UV resonance lines (especially the unsaturated doublet of P v) can also be reproduced with no problem when macroclumping is taken into account. There is no need to artificially reduce the mass-loss rates or to assume a subsolar phosphorus abundance or an extremely high clumping factor, unlike what was claimed by other authors. These consistent mass-loss rates are lower by a factor of 1.3 to 2.6, compared to the mass-loss rate recipe from Vink et al. Conclusions: Macroclumping resolves the previously reported discrepancy between Hα and P v mass-loss diagnostics. Based on

  19. Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

    NARCIS (Netherlands)

    Brown, Sara J.; Asai, Yuka; Cordell, Heather J.; Campbell, Linda E.; Zhao, Yiwei; Liao, Haihui; Northstone, Kate; Henderson, John; Alizadehfar, Reza; Ben-Shoshan, Moshe; Morgan, Kenneth; Roberts, Graham; Masthoff, Laury J. N.; Pasmans, Suzanne G. M. A.; van den Akker, Peter C.; Wijmenga, Cisca; Hourihane, Jonathan O'B.; Palmer, Colin N. A.; Lack, Gideon; Clarke, Ann; Hull, Peter R.; Irvine, Alan D.; McLean, W. H. Irwin

    Background: IgE-mediated peanut allergy is a complex trait with strong heritability, but its genetic basis is currently unknown. Loss-of-function mutations within the filaggrin gene are associated with atopic dermatitis and other atopic diseases; therefore, filaggrin is a candidate gene in the

  20. New Mass-Conserving Bedrock Topography for Pine Island Glacier Impacts Simulated Decadal Rates of Mass Loss

    Science.gov (United States)

    Nias, I. J.; Cornford, S. L.; Payne, A. J.

    2018-04-01

    High-resolution ice flow modeling requires bedrock elevation and ice thickness data, consistent with one another and with modeled physics. Previous studies have shown that gridded ice thickness products that rely on standard interpolation techniques (such as Bedmap2) can be inconsistent with the conservation of mass, given observed velocity, surface elevation change, and surface mass balance, for example, near the grounding line of Pine Island Glacier, West Antarctica. Using the BISICLES ice flow model, we compare results of simulations using both Bedmap2 bedrock and thickness data, and a new interpolation method that respects mass conservation. We find that simulations using the new geometry result in higher sea level contribution than Bedmap2 and reveal decadal-scale trends in the ice stream dynamics. We test the impact of several sliding laws and find that it is at least as important to accurately represent the bedrock and initial ice thickness as the choice of sliding law.

  1. Water vapor concentration dependence and temperature dependence of Li mass loss from Li{sub 2}TiO{sub 3} with excess Li and Li{sub 4}SiO{sub 4}

    Energy Technology Data Exchange (ETDEWEB)

    Shimozori, Motoki [Interdisciplinary Graduate School of Engineering Science, Kyushu University, 6-1, Kasugakoen, Kasuga, Fukuoka 816-8580 (Japan); Katayama, Kazunari, E-mail: kadzu@nucl.kyushu-u.ac.jp [Interdisciplinary Graduate School of Engineering Science, Kyushu University, 6-1, Kasugakoen, Kasuga, Fukuoka 816-8580 (Japan); Hoshino, Tsuyoshi [Breeding Functional Materials Development Group, Department of Blanket Systems Research, Rokkasho Fusion Institute, Sector of Fusion Research and Development, Japan Atomic Energy Agency, 2-166 Obuch, Omotedate, Rokkasho-mura, Kamikita-gun, Aomori 039-3212 (Japan); Ushida, Hiroki; Yamamoto, Ryotaro; Fukada, Satoshi [Interdisciplinary Graduate School of Engineering Science, Kyushu University, 6-1, Kasugakoen, Kasuga, Fukuoka 816-8580 (Japan)

    2015-10-15

    Highlights: • Li mass loss from Li{sub 2.11}TiO{sub 3} increased proportionally to water vapor pressure. • Li mass loss from Li{sub 2.11}TiO{sub 3} at 600 °C was significantly smaller than expected. • Differences of Li mass loss behavior from Li{sub 2.11}TiO{sub 3} and Li{sub 4}SiO{sub 4} were shown. - Abstract: In this study, weight reduction of Li{sub 2}TiO{sub 3} with excess Li and Li{sub 4}SiO{sub 4} at elevated temperatures under hydrogen atmosphere or water vapor atmosphere was investigated. The Li mass loss for the Li{sub 2}TiO{sub 3} at 900 °C was 0.4 wt% under 1000 Pa H{sub 2} atmosphere and 1.5 wt% under 50 Pa H{sub 2}O atmosphere. The Li mass loss for the Li{sub 2}TiO{sub 3} increased proportionally to the water vapor pressure in the range from 50 to 200 Pa at 900 °C and increased with increasing temperature from 700 to 900 °C although Li mass loss at 600 °C was significantly smaller than expected. It was found that water vapor concentration dependence and temperature dependence of Li mass loss for the Li{sub 2}TiO{sub 3} and the Li{sub 4}SiO{sub 4} used in this work were quite different. Water vapor is released from the ceramic breeder materials into the purge gas due to desorption of adsorbed water and water formation reaction. The released water vapor possibly promotes Li mass loss with the formation of LiOH on the surface.

  2. Uplift rates from a new high-density GPS network in Palmer Land indicate significant late Holocene ice loss in the southwestern Weddell Sea

    DEFF Research Database (Denmark)

    Wolstencroft, Martin; King, Matt A.; Whitehouse, Pippa L

    2015-01-01

    The measurement of ongoing ice-mass loss and associated melt water contribution to sea-level change from regions such as West Antarctica is dependent on a combination of remote sensing methods. A key method, the measurement of changes in Earth's gravity via the GRACE satellite mission, requires...... a potentially large correction to account for the isostatic response of the solid Earth to ice-load changes since the Last Glacial Maximum. In this study, we combine glacial isostatic adjustment modelling with a new GPS dataset of solid Earth deformation for the southern Antarctic Peninsula to test the current...... understanding of ice history in this region. A sufficiently complete history of past ice-load change is required for glacial isostatic adjustment models to accurately predict the spatial variation of ongoing solid Earth deformation, once the independently-constrained effects of present-day ice mass loss have...

  3. The significance of circumscribed malignant mammographic masses in the surveillance of BRCA 1/2 gene mutation carriers

    International Nuclear Information System (INIS)

    Kaas, R.; Kroger, R.; Besnard, A.P.E.; Koops, W.; Pameijer, F.A.; Prevoo, W.; Loo, C.E.; Muller, S.H.; Hendriks, J.H.C.L.

    2004-01-01

    Breast cancers in gene mutation carriers may escape mammographic detection because of rapid growth and tumor expansion. Therefore, they may mimic benign lesions on the mammogram. Twenty-nine BRCA 1/2 mutation carriers under surveillance developed 31 breast cancers between 1994 and 2001 at a mean age of 44.2 years. Controls were 63 women with 67 breast cancers in the same period at a mean age of 53.8 years, also under surveillance because of a life time risk of at least 15%. In 26% of the carriers vs. 48% of the controls, mammography was the method that first suspected a malignancy. Seven radiologists performed a retrospective review of the original mammograms to establish technical assessment, with special attention for circumscribed lesions and estimated probability of malignancy. In the mutation carriers seven (23%) circumscribed non-calcified mammographic masses were found and three in the controls (4.5%) P=0.01. These masses were proven to be malignant. In both groups around 70% of these fast-growing circumscribed lesions were detected by the patients. The masses were situated in breasts with a good interpretable breast pattern. BRCA 1/2 mutation carriers had a significantly higher percentage of circumscribed non-calcified mammographic masses that proved to be malignant. These mammographic lesions in women at high risk should be described as at least Birads 0 and worked-up with ultrasound and needle biopsy. (orig.)

  4. Stable Isotope Mass Balance of the Laurentian Great Lakes to Constrain Evaporative Losses

    Energy Technology Data Exchange (ETDEWEB)

    Jasechko, S. [Department of Earth and Environmental Sciences, University of Waterloo, Waterloo, Ontario and Alberta Innovates, Technology Futures, Victoria, British Columbia (Canada); Gibson, J. J. [Canada Alberta Innovates, Technology Futures, Victoria, British Columbia and Department of Geography, University of Victoria, Victoria, British Columbia (Canada); Pietroniro, A. [National Water Research Institute, Environment Canada, Saskatoon, Saskatchewan (Canada); Edwards, T.W D. [Department of Earth and Environmental Sciences, University of Waterloo, Waterloo, Ontario (Canada)

    2013-07-15

    Evaporation is an important yet poorly constrained component of the water budget of the Laurentian Great Lakes, but is known historically to have a significant impact on regional climate, including enhanced humidity and downwind lake effect precipitation. Sparse over lake climate monitoring continues to limit ability to quantify bulk lake evaporation and precipitation rates by physical measurements, impeded by logistical difficulties and costs of instrumenting large areas of open water (10{sup 3}-10{sup 5} km2). Measurements of stable isotopes of oxygen and hydrogen in water samples of precipitation and surface waters within the great lakes basin are used to better understand the controls on the region's water cycle. A stable isotope mass balance approach to calculate long term evaporation as a proportion of input to each lake is discussed. The approach capitalizes on the well understood systematic isotopic separation of an evaporating water body, but includes added considerations for internal recycling of evaporated moisture in the overlying atmosphere that should be incorporated for surface waters sufficiently large to significantly influence surrounding climate. (author)

  5. Non-targeted glycosidic profiling of international wines using neutral loss-high resolution mass spectrometry.

    Science.gov (United States)

    Barnaba, C; Dellacassa, E; Nicolini, G; Nardin, T; Serra, M; Larcher, R

    2018-07-06

    Many metabolites naturally occur as glycosides, since sugar moieties can be crucial for their biological activity and increase their water solubility. In the plant kingdom they may occur as glycosides or sugar esters, depending on precursor chemical structure, and in wine they have traditionally attracted attention due to their organoleptic properties, such as astringency and bitterness, and because they affect the colour and aroma of wines. A new approach directed at detailed description of glycosides in a large selection of monovarietal wines (8 samples each of Pinot Blanc, Muller Thurgau, Riesling, Traminer, Merlot, Pinot Noir and Cabernet Sauvignon) was developed by combining high performance liquid chromatography with high resolution tandem mass spectrometry. Analytical separation was performed on an Accucore™ Polar Premium LC column, while mass analysis was performed in negative ion mode with an non-targeted screening approach, using a Full MS/AIF/NL dd-MS 2 experiment at a resolving power of 140,000 FWHM. Over 280 glycoside-like compounds were detected, of which 133 (including low-molecular weight phenols, flavonoids and monoterpenols) were tentatively identified in the form of pentose (6), deoxyhexose (17), hexose (73), hexose-pentose (16), hexose-deoxyhexose (7), dihexose (5) and hexose ester (9) derivatives. It was not possible to univocally define the corresponding chemical structure for the remaining 149 glycosides. Non-parametric statistical analysis showed it was possible to well characterise the glycosylated profile of all red and Traminer wines, while the identified glycosides were almost entirely lacking in Pinot Blanc, Riesling and Muller Thurgau wines. Also Tukey's Honestly Significant Difference test (p wines from each other according to their glycosylated profile. Copyright © 2018 Elsevier B.V. All rights reserved.

  6. Iatrogenic hyperthyroidism does not promote weight loss or prevent ageing-related increases in body mass in thyroid cancer survivors.

    Science.gov (United States)

    Polotsky, Hanah N; Brokhin, Matvey; Omry, Gal; Polotsky, Alex J; Tuttle, R Michael

    2012-04-01

    Thyroid cancer survivors represent a unique population in which the potential long-term effects of brief periods of intentional thyroid hormone withdrawal and/or prolonged periods of iatrogenic hyperthyroidism on body weight and body mass were evaluated. The objectives of this study were to characterize body mass changes over several years in a cohort of thyroid cancer patients with iatrogenic hyperthyroidism and to compare these changes with the expected weight gain in age-matched healthy control populations. We also evaluated the possibility that the method of preparation [thyroid hormone withdrawal (THW) vs recombinant human TSH (rhTSH)] for radioactive iodine remnant ablation may be associated with differences in body mass at the time of the final follow-up. DESIGN/SETTING/PATIENTS/INTERVENTIONS: A retrospective review identified 153 patients with thyroid cancer who underwent total thyroidectomy at one major medical centre. Of the 153 patients, 143 also had radioactive iodine remnant ablation: 70 after THW and 73 after rhTSH. Change in weight and BMI at 1-2 and 3-5 years of follow-up points were examined. Annualized weight variation within the cohort was compared with age-matched population controls expressed in kilogram/year. Significant weight gain was noted for the full cohort after 3-5 years of follow-up as compared to baseline (76 ± 21 kg at baseline vs 79 ± 23 kg at 3-5 years of follow-up, P weight, respectively, which is similar or somewhat higher than previously published age-matched population controls (ranging from 0·23 to 0·34 kg/year). When expressed as per cent change and comparing the final weight to the pre-operative baseline, the rhTSH group experienced approximately a 1·7% increase in weight compared with the 3·9% increase seen with THW patients (P = 0·02). When expressed as kg/year change, the rhTSH cohort had 0·34 kg/year change compared with the 0·64 kg/year change seen in the thyroid hormone withdrawal patients (P = 0·02). In

  7. A 7-day high protein hypocaloric diet promotes cellular metabolic adaptations and attenuates lean mass loss in healthy males

    Directory of Open Access Journals (Sweden)

    Matthew Furber

    2017-08-01

    Full Text Available Mitochondrial quantity and density are associated with increased oxidative metabolism. It has been demonstrated that a hypocaloric high fat/low carbohydrate (HF/LC diet can up-regulate transcriptional markers of mitochondrial biogenesis; this was yet to be explored in vivo subsequent to a high protein/low carbohydrate (HP/LC diet. Thus the aims of the study were to explore such diets on transcriptional markers or mitochondrial biogenesis, body composition and resting metabolic rate (RMR. Forty-five healthy male participants were randomly assigned one of four intervention diets: eucaloric high protein low carbohydrate (PRO-EM, hypocaloric high protein low carbohydrate (PRO-ER, eucaloric high carbohydrate (CHO-EM or hypocaloric high carbohydrate (CHO-ER. The macronutrient ratio of the high protein diet and high carbohydrate diets was 40:30:30% and 10:60:30% (PRO:CHO:FAT respectively. Energy intake for the hypocaloric diets were calculated to match resting metabolic rate. Participants visited the laboratory on 3 occasions each separated by 7 days. On each visit body composition, resting metabolic rate and a muscle biopsy from the vastus lateralis was collected. Prior to visit 1 and 2 habitual diet was consumed which was used as a control, between visit 2 and 3 the intervention diet was consumed continuously for 7-days. No group × time effect was observed, however in the PRO-ER group a significant increase in AMPK, PGC-1α, SIRT1 and SIRT3 mRNA expression was observed post diet intervention groups (p < 0.05. No change was observed in any of the transcriptional markers in the other 3 groups. Despite ∼30% reduction in calorie intake no difference in lean mass (LM loss was observed between the PRO-ER and CHO-EM groups. The results from this study suggest that a 7-day a high protein low carbohydrate hypocaloric diet increased AMPK, SIRT1 and PGC-1 α mRNA expression at rest, and also suggest that increased dietary protein may attenuate LM mass

  8. An 800-million-solar-mass black hole in a significantly neutral Universe at a redshift of 7.5.

    Science.gov (United States)

    Bañados, Eduardo; Venemans, Bram P; Mazzucchelli, Chiara; Farina, Emanuele P; Walter, Fabian; Wang, Feige; Decarli, Roberto; Stern, Daniel; Fan, Xiaohui; Davies, Frederick B; Hennawi, Joseph F; Simcoe, Robert A; Turner, Monica L; Rix, Hans-Walter; Yang, Jinyi; Kelson, Daniel D; Rudie, Gwen C; Winters, Jan Martin

    2018-01-25

    Quasars are the most luminous non-transient objects known and as a result they enable studies of the Universe at the earliest cosmic epochs. Despite extensive efforts, however, the quasar ULAS J1120 + 0641 at redshift z = 7.09 has remained the only one known at z > 7 for more than half a decade. Here we report observations of the quasar ULAS J134208.10 + 092838.61 (hereafter J1342 + 0928) at redshift z = 7.54. This quasar has a bolometric luminosity of 4 × 10 13 times the luminosity of the Sun and a black-hole mass of 8 × 10 8 solar masses. The existence of this supermassive black hole when the Universe was only 690 million years old-just five per cent of its current age-reinforces models of early black-hole growth that allow black holes with initial masses of more than about 10 4 solar masses or episodic hyper-Eddington accretion. We see strong evidence of absorption of the spectrum of the quasar redwards of the Lyman α emission line (the Gunn-Peterson damping wing), as would be expected if a significant amount (more than 10 per cent) of the hydrogen in the intergalactic medium surrounding J1342 + 0928 is neutral. We derive such a significant fraction of neutral hydrogen, although the exact fraction depends on the modelling. However, even in our most conservative analysis we find a fraction of more than 0.33 (0.11) at 68 per cent (95 per cent) probability, indicating that we are probing well within the reionization epoch of the Universe.

  9. Can mountain glacier melting explains the GRACE-observed mass loss in the southeast Tibetan Plateau: From a climate perspective?

    Science.gov (United States)

    Song, Chunqiao; Ke, Linghong; Huang, Bo; Richards, Keith S.

    2015-01-01

    The southeast Tibetan Plateau (SETP) includes the majority of monsoonal temperate glaciers in High Mountain Asia (HMA), which is an important source of water for the upper reaches of several large Asian river systems. Climatic change and variability has substantial impacts on cryosphere and hydrological processes in the SETP. The Gravity Recovery and Climate Experiment (GRACE) gravimetry observations between 2003 and 2009 suggest that there was an average mass loss rate of - 5.99 ± 2.78 Gigatonnes (Gt)/yr in this region. Meanwhile, the hydrological data by model calculations from the GLDAS/Noah and CPC are used to estimate terrestrial water storage (TWS) changes with a slight negative trend of about - 0.3 Gt/yr. The recent studies (Kääb et al., 2012; Gardner et al., 2013) reported the thinning rates of mountain glaciers in HMA based on the satellite laser altimetry, and an approximate estimation of the glacier mass budget in the SETP was 4.69 ± 2.03 Gt/yr during 2003-2009. This estimate accounted for a large proportion ( 78.3%) of the difference between the GRACE TWS and model-calculated TWS changes. To better understand the cause of sharp mass loss existing in the SETP, the correlations between key climatic variables (precipitation and temperature) and the GRACE TWS changes are examined at different timescales between 2003 and 2011. The results show that precipitation is the leading factors of abrupt, seasonal and multi-year undulating signals of GRACE TWS anomaly time series, but with weak correlations with the inter-annual trend and annual mass budget of GRACE TWS. In contrast, the annual mean temperature is tightly associated with the annual net mass budget (r = 0.81, p < 0.01), which indirectly suggests that the GRACE-observed mass loss in the SETP may be highly related to glacial processes.

  10. Accelerated modern human?induced species losses: Entering the sixth mass extinction

    OpenAIRE

    Ceballos, Gerardo; Ehrlich, Paul R.; Barnosky, Anthony D.; Garc?a, Andr?s; Pringle, Robert M.; Palmer, Todd M.

    2015-01-01

    The oft-repeated claim that Earth?s biota is entering a sixth ?mass extinction? depends on clearly demonstrating that current extinction rates are far above the ?background? rates prevailing between the five previous mass extinctions. Earlier estimates of extinction rates have been criticized for using assumptions that might overestimate the severity of the extinction crisis. We assess, using extremely conservative assumptions, whether human activities are causing a mass extinction. First, we...

  11. Role of Protein Carbonylation in Skeletal Muscle Mass Loss Associated with Chronic Conditions

    Directory of Open Access Journals (Sweden)

    Esther Barreiro

    2016-05-01

    Full Text Available Muscle dysfunction, characterized by a reductive remodeling of muscle fibers, is a common systemic manifestation in highly prevalent conditions such as chronic heart failure (CHF, chronic obstructive pulmonary disease (COPD, cancer cachexia, and critically ill patients. Skeletal muscle dysfunction and impaired muscle mass may predict morbidity and mortality in patients with chronic diseases, regardless of the underlying condition. High levels of oxidants may alter function and structure of key cellular molecules such as proteins, DNA, and lipids, leading to cellular injury and death. Protein oxidation including protein carbonylation was demonstrated to modify enzyme activity and DNA binding of transcription factors, while also rendering proteins more prone to proteolytic degradation. Given the relevance of protein oxidation in the pathophysiology of many chronic conditions and their comorbidities, the current review focuses on the analysis of different studies in which the biological and clinical significance of the modifications induced by reactive carbonyls on proteins have been explored so far in skeletal muscles of patients and animal models of chronic conditions such as COPD, disuse muscle atrophy, cancer cachexia, sepsis, and physiological aging. Future research will elucidate the specific impact and sites of reactive carbonyls on muscle protein content and function in human conditions.

  12. Effects of Exercise Training on Fat Loss and Lean Mass Gain in Mexican-American and Korean Premenopausal Women

    Directory of Open Access Journals (Sweden)

    Shenghui Wu

    2017-01-01

    Full Text Available We investigated the effect of exercise training on body composition change in women. Nineteen Mexican-American and 18 Korean premenopausal overweight/obese women were randomized into one of the following groups: control, low-intensity training group (LI, and high-intensity training group (HI. Subjects completed 12 weeks of training at 50–56% maximal oxygen consumption (LI or 65–70% maximal oxygen consumption (HI. Body composition components were measured at baseline and after training using dual-energy X-ray absorptiometry for Mexican-Americans, while whole-body composition was measured by the direct segmental multifrequency bioelectrical impedance analysis and abdominal fat was measured by single-slice computed tomography for Koreans. Data were analyzed using mixed-model repeated measures independent of age, ethnicity, and body mass index (BMI. Exercise training showed a significant effect on BMI, fat percentage, fat mass, lean mass, and visceral adipose tissue area. HI significantly decreased fat mass and fat percentage but increased lean mass (all P<0.05. LI significantly reduced BMI, fat mass, fat percentage, and visceral adipose tissue area but increased lean mass (all P<0.05. Exercise training had a beneficial effect on reducing BMI, fat percentage, fat mass, and visceral adipose tissue area but had no effect on increasing lean mass for Mexican-American and Korean premenopausal overweight/obese women.

  13. Total body calcium by neutron activation analysis in normals and osteoporotic populations: a discriminator of significant bone mass loss

    International Nuclear Information System (INIS)

    Ott, S.M.; Murano, R.; Lewellen, T.K.; Nelp, W.B.; Chesnut, C.M.

    1983-01-01

    Measurements of total body calcium by neutron activation (TBC) in 94 normal individuals and 86 osteoporotic patients are reported. The ability of TBC to discriminate normal from osteoporotic females was evaluated with decision analysis. Bone mineral content (BMC) by single-photon absorptiometry was also measured. TBC was higher in males (range 826 to 1363 gm vs 537 to 1054 in females) and correlated with height in all normals. In females over age 55 there was a negative correlation with age. Thus, for normals an algorithm was derived to allow comparison between measured TBC and that predicted by sex, age, and height (TBCp). In the 28 normal females over age 55, the TBC was 764 +/- 115 gm vs. 616 +/- 90 in the osteoporotics. In 63 of the osteoporotic females an estimated height, from tibial length, was used to predict TBC. In normals the TBC/TBCp ratio was 1.00 +/- 0.12, whereas in osteoporotic females it was 0.80 +/- 0.12. A receiver operating characteristic curve showed better discrimination of osteoporosis with TBC/TBCp than with wrist BMC. By using Bayes' theorem, with a 25% prevalence of osteoporosis (estimate for postmenopausal women), the posttest probability of disease was 90% when the TBC/TBCp ratio was less than 0.84. The authors conclude that a low TBC/TBCp ratio is very helpful in determining osteoporosis

  14. Variation in C-reactive protein following weight loss in obese insulin resistant postmenopausal women: is there an independent contribution of lean body mass?

    Science.gov (United States)

    Barsalani, R; Riesco, É; Perreault, K; Imbeault, P; Brochu, M; Dionne, I J

    2015-03-01

    We showed that obese insulin resistant postmenopausal women are characterized by higher lean body mass and elevated C-reactive protein. Although counterintuitive, we hypothesized that losses in muscle mass following caloric restriction and increase in muscle quality will be associated with improvements in glucose homeostasis through decreases in C-reactive protein. To determine 1) if improvements in C-reactive protein concentrations occurs through losses in lean body mass; and 2) if decreases in C-reactive protein levels contribute to improvements in insulin sensitivity. 50 postmenopausal women (body mass index>26 kg/m(²)) with impaired glucose disposal (program. Outcome measures were: Glucose disposal rate: M value (by hyperinsulinemic-euglycemic clamp), body composition (total, trunk, and appendicluar). LBM and FM by DXA), LBM index (LBM (kg)/height (m(2)), body fat distribution (VAT and SAT by CT scan) and plasma high-sensitive C-reactive protein (hsCRP) and interleukin-6 (Il-6). Significant correlations were observed between Δ hsCRP levels with Δ Il-6 (r=0.33, p≤0.05), Δ total LBM index (r=0.44, p≤0.01), Δ trunk LBM (r=0.38, p≤0.01) Δ SAT (r=0.35, p≤0.05) and ∆ glucose disposal rate (r=- 0.44, p≤0.01). After including all the correlated variables in Stepwise linear regression model, Δ LBM index was the only independent predictor of the reduction in hsCRP levels (R(2)=0.20, p≤0.01). Losses in total lean body mass are independently associated with improvements in inflammatory state (CRP levels) in obese postmenopausal women with impaired glucose disposal. © Georg Thieme Verlag KG Stuttgart · New York.

  15. Spatial and temporal distribution of mass loss from the Greenland Ice Sheet since AD 1900

    DEFF Research Database (Denmark)

    Kjeldsen, Kristian Kjellerup; Korsgaard, Niels J.; Bjørk, Anders A

    2015-01-01

    the mass balance into a term for surface mass balance (that is, total precipitation minus total sublimation minus runoff) and a dynamic term. We find that many areas currently undergoing change are identical to those that experienced considerable thinning throughout the twentieth century. We also reveal...

  16. Mass loss from OB supergiants in x-ray binary systems

    International Nuclear Information System (INIS)

    Alme, M.L.; Wilson, J.R.

    1975-01-01

    A study of the atmospheres of OB supergiants in x-ray binary systems indicates that when the stellar surface is close enough to the saddle in the gravitational potential to provide a mass transfer rate adequate to power a compact x-ray source, large-amplitude variations in the rate of mass flow occur. 9 references

  17. A well-balanced diet combined or not with exercise induces fat mass loss without any decrease of bone mass despite bone micro-architecture alterations in obese rat.

    Science.gov (United States)

    Gerbaix, Maude; Metz, Lore; Mac-Way, Fabrice; Lavet, Cédric; Guillet, Christelle; Walrand, Stéphane; Masgrau, Aurélie; Vico, Laurence; Courteix, Daniel

    2013-04-01

    The association of a well-balanced diet with exercise is a key strategy to treat obesity. However, weight loss is linked to an accelerated bone loss. Furthermore, exercise is known to induce beneficial effects on bone. We investigated the impact of a well-balanced isoenergetic reducing diet (WBR) and exercise on bone tissue in obese rats. Sixty male rats had previously been fed with a high fat/high sucrose diet (HF/HS) for 4months to induce obesity. Then, 4 regimens were initiated for 2months: HF/HS diet plus exercise (treadmill: 50min/day, 5days/week), WBR diet plus exercise, HF/HS diet plus inactivity and WBR diet plus inactivity. Body composition and total BMD were assessed using DXA and visceral fat mass was weighed. Tibia densitometry was assessed by Piximus. Bone histomorphometry was performed on the proximal metaphysis of tibia and on L2 vertebrae (L2). Trabecular micro-architectural parameters were measured on tibia and L2 by 3D microtomography. Plasma concentration of osteocalcin and CTX were measured. Both WBR diet and exercise had decreased global weight, global fat and visceral fat mass (pdiet alone failed to alter total and tibia bone mass and BMD. However, Tb.Th, bone volume density and degree of anisotropy of tibia were decreased by the WBR diet (pdiet had involved a significant lower MS/BS and BFR/BS in L2 (pdiet inducing weight and fat mass losses did not affected bone mass and BMD of obese rats despite alterations of their bone micro-architecture. The moderate intensity exercise performed had improved the tibia BMD of obese rats without any trabecular and cortical adaptation. Copyright © 2013 Elsevier Inc. All rights reserved.

  18. Measuring Two Decades of Ice Mass Loss using GRACE and SLR

    Science.gov (United States)

    Bonin, J. A.; Chambers, D. P.

    2016-12-01

    We use Satellite Laser Ranging (SLR) to extend the time series of ice mass change back in time to 1994. The SLR series is of far lesser spatial resolution than GRACE, so we apply a constrained inversion technique to better localize the signal. We approximate the likely errors due to SLR's measurement errors combined with the inversion errors from using a low-resolution series, then estimate the interannual mass change over Greenland and Antarctica.

  19. Do psychological factors help to reduce body mass in obesity or is it vice versa? Selected psychological aspects and effectiveness of the weight-loss program in the obese patients

    Directory of Open Access Journals (Sweden)

    Monika Bąk-Sosnowska

    2013-03-01

    Full Text Available The aim of this study was to assess the strength and direction of the correlation between cognitive appraisal, emotional state, social functioning and the effectiveness of a weight-loss program undertaken by obese subjects. The out-patient weight-loss program encompassed 150 obese women. Assessments were carried out at four time points: at the start of the weight-loss program and then after a 5%, 10% and a 15% reduction of the initial body mass. The research tools used were: a survey, the Situation Appraisal Questionnaire (SAQ, the Emotional State Questionnaire (ESQ, and the Q-Sort Social Functioning Questionnaire. The cognitive appraisal, emotional state and social functioning of the study group changed significantly (P<0.001. Significantly more individuals with a 15% body mass reduction, as compared with individuals with no body mass reduction, had an early obesity onset, i.e. at the age of <10 years old (P<0.001. Significantly more individuals with no body mass reduction, compared with individuals with a 15% reduction, had a later obesity onset, i.e. between the ages of 20 and 30 (P<0.001 and between 50 and 60 (P<0.001. Significantly more individuals with a 15% body mass reduction, compared with individuals with no mass reduction, had previously experienced the jojo effect (P<0.001 and had successfully lost weight (P<0.001. Significantly more individuals with no body mass reduction, compared with individuals with a15% reduction, had a history of unsuccessful attempts at reducing body mass (P<0.001. We conclude that the attitude of obese patients towards a weight-loss program is not a deciding factor for its effectiveness. As body mass reduces, the attitude improves.

  20. ESCAPING PARTICLE FLUXES IN THE ATMOSPHERES OF CLOSE-IN EXOPLANETS. II. REDUCED MASS-LOSS RATES AND ANISOTROPIC WINDS

    International Nuclear Information System (INIS)

    Guo, J. H.

    2013-01-01

    In Paper I, we presented a one-dimensional hydrodynamic model for the winds of close-in exoplanets. However, close-in exoplanets are tidally locked and irradiated only on the day sides by their host stars. This requires two-dimensional hydrodynamic models with self-consistent radiative transfer calculations. In this paper, for the tidal-locking (two-dimensional radiative transfer) and non-tidal-locking cases (one-dimensional radiative transfer), we constructed a multi-fluid two-dimensional hydrodynamic model with detailed radiative transfer to depict the escape of particles. We found that the tidal forces (the sum of tidal gravity of the star and centrifugal force due to the planetary rotation) supply significant accelerations and result in anisotropic winds. An important effect of the tidal forces is that it severely depresses the outflow of particles near the polar regions where the density and the radial velocity are a factor of a few (ten) smaller than those of the low-latitude regions. As a consequence, most particles escape the surface of the planet from the regions of low latitude. Comparing the tidal-locking and non-tidal-locking cases, we found that their optical depths are very different so that the flows also emerge with a different pattern. In the case of non-tidal locking, the radial velocities at the base of the wind are higher than the meridional velocities. However, in the case of tidal locking, the meridional velocities dominate the flow at the base of the wind, and they can effectively transfer mass and energy from the day sides to the night sides. Further, we also found that the differences of the winds show a middle extent at large radii. This means that the structure of the wind at the base can be changed by the two-dimensional radiative transfer due to large optical depths, but the extent is reduced with an increase in radius. Because the escape is depressed in the polar regions, the mass-loss rate predicted by the non-tidal-locking model, in

  1. Nitrogen losses from dairy manure estimated through nitrogen mass balance and chemical markers

    Science.gov (United States)

    Hristov, Alexander N.; Zaman, S.; Vander Pol, M.; Ndegwa, P.; Campbell, L.; Silva, S.

    2009-01-01

    Ammonia is an important air and water pollutant, but the spatial variation in its concentrations presents technical difficulties in accurate determination of ammonia emissions from animal feeding operations. The objectives of this study were to investigate the relationship between ammonia volatilization and ??15N of dairy manure and the feasibility of estimating ammonia losses from a dairy facility using chemical markers. In Exp. 1, the N/P ratio in manure decreased by 30% in 14 d as cumulative ammonia losses increased exponentially. Delta 15N of manure increased throughout the course of the experiment and ??15N of emitted ammonia increased (p rights reserved.

  2. Ratio of muscle mass to fat mass assessed by bioelectrical impedance analysis is significantly correlated with liver fat accumulation in patients with type 2 diabetes mellitus.

    Science.gov (United States)

    Kurinami, Noboru; Sugiyama, Seigo; Morita, Ayami; Yoshida, Akira; Hieshima, Kunio; Miyamoto, Fumio; Kajiwara, Keizo; Jinnouch, Katsunori; Jinnouchi, Tomio; Jinnouchi, Hideaki

    2018-05-01

    Obesity and ectopic fat accumulation are important conditions of type 2 diabetes mellitus (T2DM). Our aim was to determine whether bioelectrical impedance body composition analysis combined with blood test results could estimate liver ectopic fat accumulation in patients with treatment-naïve T2DM. Subjects were 119 untreated T2DM patients. Computed tomography scans were performed to calculate the liver to spleen attenuation ratio (L/S ratio) as a measure of liver fat accumulation, with excess liver fat accumulation defined as an L/S ratio analysis using InBody770. The Nagelkerke R 2 test showed that the muscle mass/fat mass ratio (muscle/fat ratio) was the most suitable variable among anthropometric factors and body component indexes for estimating liver fat accumulation. The muscle/fat ratio was significantly correlated with the L/S ratio (ρ = 0.4386, P analysis showed that the muscle/fat ratio (odds ratio 0.40, 95% confidence interval 0.22-0.73, P ratio 1.06, 95% confidence interval 1.02-1.10, P analysis, the cutoff value of the muscle/fat ratio for excess liver fat accumulation was 2.34. In patients with treatment-naïve T2DM, the muscle/fat ratio and ALT are useful for estimating the presence of excess liver fat accumulation in daily clinical practice. Copyright © 2018. Published by Elsevier B.V.

  3. DXA, bioelectrical impedance, ultrasonography and biometry for the estimation of fat and lean mass in cats during weight loss

    Directory of Open Access Journals (Sweden)

    Borges Naida C

    2012-07-01

    Full Text Available Abstract Background Few equations have been developed in veterinary medicine compared to human medicine to predict body composition. The present study was done to evaluate the influence of weight loss on biometry (BIO, bioimpedance analysis (BIA and ultrasonography (US in cats, proposing equations to estimate fat (FM and lean (LM body mass, as compared to dual energy x-ray absorptiometry (DXA as the referenced method. For this were used 16 gonadectomized obese cats (8 males and 8 females in a weight loss program. DXA, BIO, BIA and US were performed in the obese state (T0; obese animals, after 10% of weight loss (T1 and after 20% of weight loss (T2. Stepwise regression was used to analyze the relationship between the dependent variables (FM, LM determined by DXA and the independent variables obtained by BIO, BIA and US. The better models chosen were evaluated by a simple regression analysis and means predicted vs. determined by DXA were compared to verify the accuracy of the equations. Results The independent variables determined by BIO, BIA and US that best correlated (p r2, 19 equations were selected (12 for FM, 7 for LM; however, only 7 equations accurately predicted FM and one LM of cats. Conclusions The equations with two variables are better to use because they are effective and will be an alternative method to estimate body composition in the clinical routine. For estimated lean mass the equations using body weight associated with biometrics measures can be proposed. For estimated fat mass the equations using body weight associated with bioimpedance analysis can be proposed.

  4. High-Resolution, Long-Slit Spectroscopy of VY Canis Majoris: The Evidence for Localized High Mass Loss Events

    Science.gov (United States)

    Humphreys, Roberta M.; Davidson, Kris; Ruch, Gerald; Wallerstein, George

    2005-01-01

    High spatial and spectral resolution spectroscopy of the OH/IR supergiant VY CMa and its circumstellar ejecta reveals evidence for high mass loss events from localized regions on the star occurring over the past 1000 yr. The reflected absorption lines and the extremely strong K I emission lines show a complex pattern of velocities in the ejecta. We show that the large, dusty northwest arc, expanding at ~50 km s-1 with respect to the embedded star, is kinematically distinct from the surrounding nebulosity and was ejected about 400 yr ago. Other large, more filamentary loops were probably expelled as much as 800-1000 yr ago, whereas knots and small arcs close to the star resulted from more recent events 100-200 yr ago. The more diffuse, uniformly distributed gas and dust is surprisingly stationary, with little or no velocity relative to the star. This is not what we would expect for the circumstellar material from an evolved red supergiant with a long history of mass loss. We therefore suggest that the high mass loss rate for VY CMa is a measure of the mass carried out by these specific ejections accompanied by streams or flows of gas through low-density regions in the dust envelope. VY CMa may thus be our most extreme example of stellar activity, but our results also bring into question the evolutionary state of this famous star. In a separate appendix, we discuss the origin of the very strong K I and other rare emission lines in its spectrum.

  5. Timing and origin of recent regional ice-mass loss in Greenland

    DEFF Research Database (Denmark)

    Sasgen, Ingo; van den Broeke, Michiel; Bamber, J.L.Jonathan L.

    2012-01-01

    and Kanagaratnam, 2006) together with output of the regional atmospheric climate modelling (RACMO2/GR; Ettema et al., 2009), and surface-elevation changes from the Ice, cloud and land elevation satellite (ICESat; Sørensen et al., 2011). We show that changing ice discharge (D), surface melting and subsequent run-off...... (M/R) and precipitation (P) all contribute, in a complex and regionally variable interplay, to the increasingly negative mass balance of the GrIS observed within the last decade. Interannual variability in P along the northwest and west coasts of the GrIS largely explains the apparent regional mass...

  6. Lycopene treatment against loss of bone mass, microarchitecture and strength in relation to regulatory mechanisms in a postmenopausal osteoporosis model.

    Science.gov (United States)

    Ardawi, Mohammed-Salleh M; Badawoud, Mohammed H; Hassan, Sherif M; Rouzi, Abdulrahim A; Ardawi, Jumanah M S; AlNosani, Nouf M; Qari, Mohammed H; Mousa, Shaker A

    2016-02-01

    Lycopene supplementation decreases oxidative stress and exhibits beneficial effects on bone health, but the mechanisms through which it alters bone metabolism in vivo remain unclear. The present study aims to evaluate the effects of lycopene treatment on postmenopausal osteoporosis. Six-month-old female Wistar rats (n=264) were sham-operated (SHAM) or ovariectomized (OVX). The SHAM group received oral vehicle only and the OVX rats were randomized into five groups receiving oral daily lycopene treatment (mg/kg body weight per day): 0 OVX (control), 15 OVX, 30 OVX, and 45 OVX, and one group receiving alendronate (ALN) (2μg/kg body weight per day), for 12weeks. Bone densitometry measurements, bone turnover markers, biomechanical testing, and histomorphometric analysis were conducted. Micro computed tomography was also used to evaluate changes in microarchitecture. Lycopene treatment suppressed the OVX-induced increase in bone turnover, as indicated by changes in biomarkers of bone metabolism: serum osteocalcin (s-OC), serum N-terminal propeptide of type 1 collagen (s-PINP), serum crosslinked carboxyterminal telopeptides (s-CTX-1), and urinary deoxypyridinoline (u-DPD). Significant improvement in OVX-induced loss of bone mass, bone strength, and microarchitectural deterioration was observed in lycopene-treated OVX animals. These effects were observed mainly at sites rich in trabecular bone, with less effect in cortical bone. Lycopene treatment down-regulated osteoclast differentiation concurrent with up-regulating osteoblast together with glutathione peroxidase (GPx) catalase (CAT) and superoxide dismutase (SOD) activities. These findings demonstrate that lycopene treatment in OVX rats primarily suppressed bone turnover to restore bone strength and microarchitecture. Copyright © 2015. Published by Elsevier Inc.

  7. Genes Whose Gain or Loss-Of-Function Increases Skeletal Muscle Mass in Mice: A Systematic Literature Review

    Directory of Open Access Journals (Sweden)

    Sander A. J. Verbrugge

    2018-05-01

    Full Text Available Skeletal muscle mass differs greatly in mice and humans and this is partially inherited. To identify muscle hypertrophy candidate genes we conducted a systematic review to identify genes whose experimental loss or gain-of-function results in significant skeletal muscle hypertrophy in mice. We found 47 genes that meet our search criteria and cause muscle hypertrophy after gene manipulation. They are from high to small effect size: Ski, Fst, Acvr2b, Akt1, Mstn, Klf10, Rheb, Igf1, Pappa, Ppard, Ikbkb, Fstl3, Atgr1a, Ucn3, Mcu, Junb, Ncor1, Gprasp1, Grb10, Mmp9, Dgkz, Ppargc1a (specifically the Ppargc1a4 isoform, Smad4, Ltbp4, Bmpr1a, Crtc2, Xiap, Dgat1, Thra, Adrb2, Asb15, Cast, Eif2b5, Bdkrb2, Tpt1, Nr3c1, Nr4a1, Gnas, Pld1, Crym, Camkk1, Yap1, Inhba, Tp53inp2, Inhbb, Nol3, Esr1. Knock out, knock down, overexpression or a higher activity of these genes causes overall muscle hypertrophy as measured by an increased muscle weight or cross sectional area. The mean effect sizes range from 5 to 345% depending on the manipulated gene as well as the muscle size variable and muscle investigated. Bioinformatical analyses reveal that Asb15, Klf10, Tpt1 are most highly expressed hypertrophy genes in human skeletal muscle when compared to other tissues. Many of the muscle hypertrophy-regulating genes are involved in transcription and ubiquitination. Especially genes belonging to three signaling pathways are able to induce hypertrophy: (a Igf1-Akt-mTOR pathway, (b myostatin-Smad signaling, and (c the angiotensin-bradykinin signaling pathway. The expression of several muscle hypertrophy-inducing genes and the phosphorylation of their protein products changes after human resistance and high intensity exercise, in maximally stimulated mouse muscle or in overloaded mouse plantaris.

  8. An altered hormonal profile and elevated rate of bone loss are associated with low bone mass in professional horse-racing jockeys.

    Science.gov (United States)

    Dolan, Eimear; McGoldrick, Adrian; Davenport, Colin; Kelleher, Grainne; Byrne, Brendan; Tormey, William; Smith, Diarmuid; Warrington, Giles D

    2012-09-01

    Horse-racing jockeys are a group of weight-restricted athletes, who have been suggested as undertaking rapid and extreme weight cycling practices in order to comply with stipulated body-mass standards. The aim of this study was to examine bone mass, turnover and endocrine function in jockeys and to compare this group with age, gender and body mass index matched controls. Twenty male professional jockeys and 20 healthy male controls participated. Dual energy X-ray absorptiometry scans and early morning fasting blood and urine samples were used to measure bone mass, turnover and a hormonal profile. Total body bone mineral density (BMD) was significantly lower in jockeys (1.143 ± 0.05 vs. 1.27 ± 0.06 g cm(-3), p professional jockeys have an elevated rate of bone loss and reduced bone mass that appears to be associated with disrupted hormonal activity. It is likely that this may have occurred in response to the chronic weight cycling habitually experienced by this group.

  9. The photometric evolution of star clusters and the preferential loss of low-mass bodies – with an application to globular clusters

    NARCIS (Netherlands)

    Kruijssen, J.M.D.; Lamers, H.J.G.L.M.

    2008-01-01

    Context. To obtain an accurate description of broad-band photometric star cluster evolution, certain effects should be accounted for. Energy equipartition leads to mass segregation and the preferential loss of low-mass stars, while stellar remnants severely influence cluster mass-to-light ratios.

  10. Physical activity as intervention for age-related loss of muscle mass and function

    DEFF Research Database (Denmark)

    Eriksen, Christian Skou; Garde, Ellen; Reislev, Nina Linde

    2016-01-01

    insights into training-induced promotion of functional ability and independency after retirement and will help to formulate national recommendations regarding physical activity schemes for the growing population of older individuals in western societies. Results will be published in scientific peer......INTRODUCTION: Physical and cognitive function decline with age, accelerating during the 6th decade. Loss of muscle power (force×velocity product) is a dominant physical determinant for loss of functional ability, especially if the lower extremities are affected. Muscle strength training is known...... to maintain or even improve muscle power as well as physical function in older adults, but the optimal type of training for beneficial long-term training effects over several years is unknown. Moreover, the impact of muscle strength training on cognitive function and brain structure remains speculative...

  11. The Search for Signatures of Transient Mass Loss in Active Stars

    NARCIS (Netherlands)

    Crosley, M.K.; Osten, R.A.; Broderick, J.W.; Corbel, S.; Eislöffel, J.; Grießmeier, J.-M.; van Leeuwen, J.; Rowlinson, A.; Zarka, P.; Norman, C.

    2016-01-01

    The habitability of an exoplanet depends on many factors. One such factor is the impact of stellar eruptive events on nearby exoplanets. Currently this is poorly constrained due to heavy reliance on solar scaling relationships and a lack of experimental evidence. Potential impacts of coronal mass

  12. Biological annihilation via the ongoing sixth mass extinction signaled by vertebrate population losses and declines

    OpenAIRE

    Ceballos, Gerardo; Ehrlich, Paul R.; Dirzo, Rodolfo

    2017-01-01

    The strong focus on species extinctions, a critical aspect of the contemporary pulse of biological extinction, leads to a common misimpression that Earth’s biota is not immediately threatened, just slowly entering an episode of major biodiversity loss. This view overlooks the current trends of population declines and extinctions. Using a sample of 27,600 terrestrial vertebrate species, and a more detailed analysis of 177 mammal species, we show the extremely high degree of population decay in...

  13. High Whey Protein Intake Delayed the Loss of Lean Body Mass in Healthy Old Rats, whereas Protein Type and Polyphenol/Antioxidant Supplementation Had No Effects

    Science.gov (United States)

    Mosoni, Laurent; Gatineau, Eva; Gatellier, Philippe; Migné, Carole; Savary-Auzeloux, Isabelle; Rémond, Didier; Rocher, Emilie; Dardevet, Dominique

    2014-01-01

    Our aim was to compare and combine 3 nutritional strategies to slow down the age-related loss of muscle mass in healthy old rats: 1) increase protein intake, which is likely to stimulate muscle protein anabolism; 2) use leucine rich, rapidly digested whey proteins as protein source (whey proteins are recognized as the most effective proteins to stimulate muscle protein anabolism). 3) Supplement animals with a mixture of chamomile extract, vitamin E, vitamin D (reducing inflammation and oxidative stress is also effective to improve muscle anabolism). Such comparisons and combinations were never tested before. Nutritional groups were: casein 12% protein, whey 12% protein, whey 18% protein and each of these groups were supplemented or not with polyphenols/antioxidants. During 6 months, we followed changes of weight, food intake, inflammation (plasma fibrinogen and alpha-2-macroglobulin) and body composition (DXA). After 6 months, we measured muscle mass, in vivo and ex-vivo fed and post-absorptive muscle protein synthesis, ex-vivo muscle proteolysis, and oxidative stress parameters (liver and muscle glutathione, SOD and total antioxidant activities, muscle carbonyls and TBARS). We showed that although micronutrient supplementation reduced inflammation and oxidative stress, the only factor that significantly reduced the loss of lean body mass was the increase in whey protein intake, with no detectable effect on muscle protein synthesis, and a tendency to reduce muscle proteolysis. We conclude that in healthy rats, increasing protein intake is an effective way to delay sarcopenia. PMID:25268515

  14. What can we learn from the self-attraction and loading fingerprints about pre-GRACE mass-loss acceleration from Greenland and Antarctica?

    Science.gov (United States)

    Davis, J. L.; Vinogradova, N. T.

    2017-12-01

    Tide-gauge records from the North Atlantic reveal significant acceleration in sea level starting in the late 20th century. We have analyzed the tide-gauge data using a model in which the accelerations are assumed to be zero prior to 1990. The estimated accelerations range from -1 to +3 m cy-2 and exhibit a systematic spatial variability. Davis and Vinogradova [2017] demonstrated that to model this variability in sea-level acceleration requires contributions from several distinct physical processes: accelerated mass loss from the Greenland and Antarctic Ice Sheets and acceleration associated with ocean circulation and heat uptake. Atmospheric pressure also contributes to the observed changes in sea level, at a much smaller amplitude. Because we are focusing on sea-level accelerations (i.e., sea-level rate changes), the contribution from Glacial Isostatic Adjustment (GIA) is negligible. Modeling of observed sea-level acceleration is achieved using external constraints for the important physical processes. Using GRACE results, we can calculate the sea-level "fingerprints" for Greenland and Antarctica associated with mass loading and gravitational perturbations. For the North Atlantic, Greenland induces a significant spatial variation in sea-level change—dominated by the solid-Earth response to the mass loss—whereas Antarctica contributes a spatially constant acceleration. The observations prefer a scaling of the solid-Earth/gravitational response, and we present the implications of this result for ice-mass changes prior to the onset of GRACE observations (2002-3).

  15. Modulation of Extreme Flood Levels by Impoundment Significantly Offset by Floodplain Loss Downstream of the Three Gorges Dam

    Science.gov (United States)

    Mei, Xuefei; Dai, Zhijun; Darby, Stephen E.; Gao, Shu; Wang, Jie; Jiang, Weiguo

    2018-04-01

    River flooding—the world's most significant natural hazard—is likely to increase under anthropogenic climate change. Most large rivers have been regulated by damming, but the extent to which these impoundments can mitigate extreme flooding remains uncertain. Here the catastrophic 2016 flood on the Changjiang River is first analyzed to assess the effects of both the Changjiang's reservoir cascade and the Three Gorges Dam (TGD), the world's largest hydraulic engineering project on downstream flood discharge and water levels. We show that the Changjiang's reservoir cascade impounded over 30.0 × 103 m3/s of flow at the peak of the flood on 25 July 2016, preventing the occurrence of what would otherwise have been the second largest flood ever recorded in the reach downstream of the TGD. Half of this flood water storage was retained by the TGD alone, meaning that impoundment by the TGD reduced peak water levels at the Datong hydrometric station (on 25 July) by 1.47 m, compared to pre-TGD conditions. However, downstream morphological changes, in particular, extensive erosion of the natural floodplain, offset this reduction in water level by 0.22 m, so that the full beneficial impact of floodwater retention by the TGD was not fully realized. Our results highlight how morphological adjustments downstream of large dams may inhibit their full potential to mitigate extreme flood risk.

  16. Impact of Weight Loss on Physical Function with Changes in Strength, Muscle Mass, and Muscle Fat Infiltration in Overweight to Moderately Obese Older Adults: A Randomized Clinical Trial

    Directory of Open Access Journals (Sweden)

    Adam J. Santanasto

    2011-01-01

    Full Text Available Purpose. Evaluate the effects of weight loss on muscle mass and area, muscle fat infiltration, strength, and their association with physical function. Methods. Thirty-six overweight to moderately obese, sedentary older adults were randomized into either a physical activity plus weight loss (PA+WL or physical activity plus successful aging health education (PA+SA program. Measurements included body composition by dual-energy X-ray absorptiometry, computerized tomography, knee extensor strength, and short physical performance battery (SPPB. Results. At 6 months, PA+WL lost greater thigh fat and muscle area compared to PA+SA. PA+WL lost 12.4% strength; PA+SA lost 1.0%. Muscle fat infiltration decreased significantly in PA+WL and PA+SA. Thigh fat area decreased 6-fold in comparison to lean area in PA+WL. Change in total SPPB score was strongly inversely correlated with change in fat but not with change in lean or strength. Conclusion. Weight loss resulted in additional improvements in function over exercise alone, primarily due to loss of body fat.

  17. Quantitative Proteomics Analysis of Altered Protein Expression in the Placental Villous Tissue of Early Pregnancy Loss Using Isobaric Tandem Mass Tags

    Directory of Open Access Journals (Sweden)

    Xiaobei Ni

    2014-01-01

    Full Text Available Many pregnant women suffer miscarriages during early gestation, but the description of these early pregnancy losses (EPL can be somewhat confusing because of the complexities of early development. Thus, the identification of proteins with different expression profiles related to early pregnancy loss is essential for understanding the comprehensive pathophysiological mechanism. In this study, we report a gel-free tandem mass tags- (TMT- labeling based proteomic analysis of five placental villous tissues from patients with early pregnancy loss and five from normal pregnant women. The application of this method resulted in the identification of 3423 proteins and 19647 peptides among the patient group and the matched normal control group. Qualitative and quantitative proteomic analysis revealed 51 proteins to be differentially abundant between the two groups (≥1.2-fold, Student's t-test, P<0.05. To obtain an overview of the biological functions of the proteins whose expression levels altered significantly in EPL group, gene ontology analysis was performed. We also investigated the twelve proteins with a difference over 1.5-fold using pathways analysis. Our results demonstrate that the gel-free TMT-based proteomic approach allows the quantification of differences in protein expression levels, which is useful for obtaining molecular insights into early pregnancy loss.

  18. A new analysis of the momentum and mass-loss rates of stellar jets

    International Nuclear Information System (INIS)

    Raga, A.C.

    1991-01-01

    A very important question in the theory of bipolar outflows from young stars is posed by the still not understood relation between molecular outflows and optical outflows (i.e., stellar jets and Herbig-Haro objects). In some past studies, estimates of mass and momentum rates associated with these outflows indicated that stellar jets have approximately 2 orders of magnitude smaller values for these parameters than the molecular outflows associated with the same sources. However, a reanalysis of observations of stellar jets in the light of new theoretical jet models yields values of mass and momentum rates comparable to the ones of molecular outflows. From this result it can be tentatively speculated that stellar jets (or Herbig-Haro objects) and molecular outflows might be different manifestations of basically the same flow. 21 refs

  19. Auditory Training for Adults Who Have Hearing Loss: A Comparison of Spaced Versus Massed Practice Schedules.

    Science.gov (United States)

    Tye-Murray, Nancy; Spehar, Brent; Barcroft, Joe; Sommers, Mitchell

    2017-08-16

    The spacing effect in human memory research refers to situations in which people learn items better when they study items in spaced intervals rather than massed intervals. This investigation was conducted to compare the efficacy of meaning-oriented auditory training when administered with a spaced versus massed practice schedule. Forty-seven adult hearing aid users received 16 hr of auditory training. Participants in a spaced group (mean age = 64.6 years, SD = 14.7) trained twice per week, and participants in a massed group (mean age = 69.6 years, SD = 17.5) trained for 5 consecutive days each week. Participants completed speech perception tests before training, immediately following training, and then 3 months later. In line with transfer appropriate processing theory, tests assessed both trained tasks and an untrained task. Auditory training improved the speech recognition performance of participants in both groups. Benefits were maintained for 3 months. No effect of practice schedule was found on overall benefits achieved, on retention of benefits, nor on generalizability of benefits to nontrained tasks. The lack of spacing effect in otherwise effective auditory training suggests that perceptual learning may be subject to different influences than are other types of learning, such as vocabulary learning. Hence, clinicians might have latitude in recommending training schedules to accommodate patients' schedules.

  20. The extraordinary mass-loss bubble G2.4 + 1.4 and its central star

    International Nuclear Information System (INIS)

    Dopita, M.A.; Mcgregor, P.J.; Rawlings, S.J.; Lozinskaia, T.A.

    1990-01-01

    Data are presented on the WR 102 star and the surrounding nebula (G2.4 + 1.4). It is shown that WR 102 and the nebula are associated, the nebula being a mass-loss bubble powered by the central star. From a photoionization analysis of the surrounding nebula, the star was determined to have the following parameters: log T(ion) = 5.20 + or - 0.05; log (R/solar R) = about 0.05; and log (L/solar L) = 5.85 + or - 0.20. 42 refs

  1. Factors affecting bone mineral mass loss after lower-limb fractures in a pediatric population.

    Science.gov (United States)

    Ceroni, Dimitri; Martin, Xavier; Kherad, Omar; Salvo, Davide; Dubois-Ferrière, Victor

    2015-06-01

    The purpose of this study was to assess the effects of the durations of cast immobilization and non-weight-bearing periods, and decreases in vigorous physical activity (VPA) on bone mineral parameters in a pediatric population treated for a lower-limb fracture. Fifty children and teenagers who had undergone a cast-mediated immobilization for a leg or ankle fracture were prospectively recruited. The durations of cast immobilization and non-weight-bearing periods were recorded for each participant. Dual-energy x-ray absorptiometry scans were performed at the time of fracture treatment (baseline) and at cast removal. Physical activity during cast immobilization was assessed using accelerometers. A strong negative correlation was found between the total duration of cast immobilization and decreases in both calcaneal bone mineral density (BMD) (r=-0.497) and total lower-limb bone mineral content (BMC) (r=-0.405). A strong negative correlation was also noted between the durations of the non-weight-bearing periods and alterations in calcaneal BMD (r=-0.420). No apparent correlations were found between lower BMD and BMC and decreased VPA. Bone mineral loss was correlated to the total duration of cast immobilization for all measurement sites on the affected leg, whereas it was only correlated to the durations of non-weight-bearing periods for calcaneal BMD and total lower-limb BMC. However, no correlations were noted between bone mineral loss and decreased VPA.

  2. Rapid Classification and Identification of Multiple Microorganisms with Accurate Statistical Significance via High-Resolution Tandem Mass Spectrometry.

    Science.gov (United States)

    Alves, Gelio; Wang, Guanghui; Ogurtsov, Aleksey Y; Drake, Steven K; Gucek, Marjan; Sacks, David B; Yu, Yi-Kuo

    2018-06-05

    Rapid and accurate identification and classification of microorganisms is of paramount importance to public health and safety. With the advance of mass spectrometry (MS) technology, the speed of identification can be greatly improved. However, the increasing number of microbes sequenced is complicating correct microbial identification even in a simple sample due to the large number of candidates present. To properly untwine candidate microbes in samples containing one or more microbes, one needs to go beyond apparent morphology or simple "fingerprinting"; to correctly prioritize the candidate microbes, one needs to have accurate statistical significance in microbial identification. We meet these challenges by using peptide-centric representations of microbes to better separate them and by augmenting our earlier analysis method that yields accurate statistical significance. Here, we present an updated analysis workflow that uses tandem MS (MS/MS) spectra for microbial identification or classification. We have demonstrated, using 226 MS/MS publicly available data files (each containing from 2500 to nearly 100,000 MS/MS spectra) and 4000 additional MS/MS data files, that the updated workflow can correctly identify multiple microbes at the genus and often the species level for samples containing more than one microbe. We have also shown that the proposed workflow computes accurate statistical significances, i.e., E values for identified peptides and unified E values for identified microbes. Our updated analysis workflow MiCId, a freely available software for Microorganism Classification and Identification, is available for download at https://www.ncbi.nlm.nih.gov/CBBresearch/Yu/downloads.html . Graphical Abstract ᅟ.

  3. Short-term variability and mass loss in Be stars. III. BRITE and SMEI satellite photometry of 28 Cygni

    Science.gov (United States)

    Baade, D.; Pigulski, A.; Rivinius, Th.; Carciofi, A. C.; Panoglou, D.; Ghoreyshi, M. R.; Handler, G.; Kuschnig, R.; Moffat, A. F. J.; Pablo, H.; Popowicz, A.; Wade, G. A.; Weiss, W. W.; Zwintz, K.

    2018-03-01

    Context. Be stars are important reference laboratories for the investigation of viscous Keplerian discs. In some cases, the disc feeder mechanism involves a combination of non-radial pulsation (NRP) modes. Aims: We seek to understand whether high-cadence photometry can shed further light on the role of NRP modes in facilitating rotation-supported mass loss. Methods: The BRITE-Constellation of nanosatellites obtained mmag photometry of 28 Cygni for 11 months in 2014-2016. We added observations with the Solar Mass Ejection Imager (SMEI) in 2003-2010 and 118 Hα line profiles, half of which were from 2016. Results: For decades, 28 Cyg has exhibited four large-amplitude frequencies: two closely spaced frequencies of spectroscopically confirmed g modes near 1.5 c/d, one slightly lower exophotospheric (Štefl) frequency, and at 0.05 c/d the difference (Δ) frequency between the two g modes. This top-level framework is indistinguishable from η Cen (Paper I), which is also very similar in spectral type, rotation rate, and viewing angle. The circumstellar (Štefl) frequency alone does not seem to be affected by the Δ frequency. The amplitude of the Δ frequency undergoes large variations; around maximum the amount of near-circumstellar matter is increased and the amplitude of the Štefl frequency grows by a factor of a few. During such brightenings dozens of transient spikes appear in the frequency spectrum; these spikes are concentrated into three groups. Only 11 frequencies were common to all years of BRITE observations. Conclusions: Be stars seem to be controlled by several coupled clocks, most of which are not very regular on timescales of weeks to months but function for decades. The combination of g modes to the slow Δ variability and/or the atmospheric response to it appears significantly non-linear. As in η Cen, the Δ variability seems to be mainly responsible for the modulation of the star-to-disc mass transfer in 28 Cyg. A hierarchical set of Δ frequencies

  4. Numerical analysis of Eucalyptus grandis × E. urophylla heat-treatment: A dynamically detecting method of mass loss during the process

    Science.gov (United States)

    Zhao, Zijian; Ma, Qing; Mu, Jun; Yi, Songlin; He, Zhengbin

    Eucalyptus particles, lamellas and boards were applied to explore a simply-implemented method with neglected heat and mass transfer to inspect the mass loss during the heat-treatment course. The results revealed that the mass loss of a certain period was theoretically the definite integration of loss rate to time in this period, and a monitoring model for mass loss speed was developed with the particles and validated with the lamellas and boards. The loss rate was correlated to the temperature and temperature-evolving speed in the model which was composed of three functions during different temperature-evolving period. The sample mass loss was calculated in the MATLAB for the lamellas and boards and the model was validated and adjusted based on the difference between the computed results and the practically measured loss values. The error ranges of the new models were -16.30% to 18.35% for wood lamellas and -9.86% to 6.80% for wood boards. This method made it possible to acquire the instantaneous loss value through continuously detecting the wood temperature evolution. This idea could provide a reference for the Eucalyptus heat-treatment to detect the treating course and control the final material characteristics.

  5. Infrared observations and mass loss of the binary system V861 Sco

    International Nuclear Information System (INIS)

    Tanzi, E.G.; Maraschi, L.; Tarenghi, M.; Treves, A.

    1981-01-01

    V 861 Sco (HD 152667) is a well known single line binary. The proposed association with a variable X-ray source has triggered renewed interest in the system. Here the authors report on a series of photometric observations in the infrared (from 1.25 to 4.8 μ) taken at various orbital phases which improve and extend previous measurements by Tanzi et al. The results give evidence of a phase modulated infrared excess which can be interpreted in terms of a non isotropic mass flow in the system or, alternately, of a contribution from a colder secondary component. (Auth.)

  6. Effect of mass loss by stellar wind on the chemical enrichment of the galaxy

    Energy Technology Data Exchange (ETDEWEB)

    Chiosi, C [Padua Univ. (Italy). Istituto di Astronomia

    1979-01-01

    The rate of production of heavy elements is rediscussed using the models of Arnett (1978) for late stage nucleosynthesis in massive stars, the M(M,) relationship of Chiosi et al. (1978b) for losing mass models in the core H and He-Burning phases, and the stellar birth rate of Miller and Scalo (1978). Contrary to that found by Wheeler et al (1978), we do not encounter the difficulty of heavy element overproduction. The explosive nucleosynthesis from massive stars is still compatible with the observed abundance distribution of the solar system, and a stellar birth rate decreasing over the history of the galactic disk.

  7. The effect of mass loss by stellar wind on the chemical enrichment of the galaxy

    International Nuclear Information System (INIS)

    Chiosi, C.

    1979-01-01

    The rate of production of heavy elements is rediscussed using the models of Arnett (1978) for late stage nucleosynthesis in massive stars, the M(M,) relationship of Chiosi et al. (1978b) for losing mass models in the core H and He-Burning phases, and the stellar birth rate of Miller and Scalo (1978). Contrary to that found by Wheeler et al (1978), we do not encounter the difficulty of heavy element overproduction. The explosive nucleosynthesis from massive stars is still compatible with the observed abundance distribution of the solar system, and a stellar birth rate decreasing over the history of the galactic disk. (orig.)

  8. Method for the elucidation of the elemental composition of low molecular mass chemicals using exact masses of product ions and neutral losses: application to environmental chemicals measured by liquid chromatography with hybrid quadrupole/time-of-flight mass spectrometry.

    Science.gov (United States)

    Suzuki, Shigeru; Ishii, Tetsuko; Yasuhara, Akio; Sakai, Shinichi

    2005-01-01

    A method for elucidating the elemental compositions of low molecular weight chemicals, based primarily on mass measurements made using liquid chromatography (LC) with time-of-flight mass spectrometry (TOFMS) and quadrupole/time-of-flight mass spectrometry (LC/QTOFMS), was developed and tested for 113 chemicals of environmental interest with molecular masses up to approximately 400 Da. As the algorithm incorporating the method is not affected by differences in the instrument used, or by the ionization method and other ionization conditions, the method is useful not only for LC/TOFMS, but also for all kinds of mass spectra measured with higher accuracy and precision (uncertainties of a few mDa) employing all ionization methods and on-line separation techniques. The method involves calculating candidate compositions for intact ionized molecules (ionized forms of the sample molecule that have lost or gained no more than a proton, i.e., [M+H](+) or [M-H](-)) as well as for fragment ions and corresponding neutral losses, and eliminating those atomic compositions for the molecules that are inconsistent with the corresponding candidate compositions of fragment ions and neutral losses. Candidate compositions were calculated for the measured masses of the intact ionized molecules and of the fragment ions and corresponding neutral losses, using mass uncertainties of 2 and 5 mDa, respectively. Compositions proposed for the ionized molecule that did not correspond to the sum of the compositions of a candidate fragment ion and its corresponding neutral loss were discarded. One, 2-5, 6-10, 11-20, and >20 candidate compositions were found for 65%, 39%, 1%, 1%, and 0%, respectively, for the 124 ionized molecules formed from the 113 chemicals tested (both positive and negative ions were obtained from 11 of the chemicals). However, no candidate composition was found for 2% of the test cases (i.e., 3 chemicals), for each of which the measured mass of one of the product ions was in

  9. Mass loss and chemical structures of wheat and maize straws in response to ultraviolet-B radiation and soil contact

    Science.gov (United States)

    Zhou, Guixiang; Zhang, Jiabao; Mao, Jingdong; Zhang, Congzhi; Chen, Lin; Xin, Xiuli; Zhao, Bingzi

    2015-01-01

    The role of photodegradation, an abiotic process, has been largely overlooked during straw decomposition in mesic ecosystems. We investigated the mass loss and chemical structures of straw decomposition in response to elevated UV-B radiation with or without soil contact over a 12-month litterbag experiment. Wheat and maize straw samples with and without soil contact were exposed to three radiation levels: a no-sunlight control, ambient solar UV-B, and artificially elevated UV-B radiation. A block control with soil contact was not included. Compared with the no-sunlight control, UV-B radiation increased the mass loss by 14–19% and the ambient radiation by 9–16% for wheat and maize straws without soil contact after 12 months. Elevated UV-B exposure decreased the decomposition rates of both wheat and maize straws when in contact with soil. Light exposure resulted in decreased O-alkyl carbons and increased alkyl carbons for both the wheat and maize straws compared with no-sunlight control. The difference in soil contact may influence the contribution of photodegradation to the overall straw decomposition process. These results indicate that we must take into account the effects of photodegradation when explaining the mechanisms of straw decomposition in mesic ecosystems. PMID:26423726

  10. Mass loss and chemical structures of wheat and maize straws in response to ultraviolet-B radiation and soil contact.

    Science.gov (United States)

    Zhou, Guixiang; Zhang, Jiabao; Mao, Jingdong; Zhang, Congzhi; Chen, Lin; Xin, Xiuli; Zhao, Bingzi

    2015-10-01

    The role of photodegradation, an abiotic process, has been largely overlooked during straw decomposition in mesic ecosystems. We investigated the mass loss and chemical structures of straw decomposition in response to elevated UV-B radiation with or without soil contact over a 12-month litterbag experiment. Wheat and maize straw samples with and without soil contact were exposed to three radiation levels: a no-sunlight control, ambient solar UV-B, and artificially elevated UV-B radiation. A block control with soil contact was not included. Compared with the no-sunlight control, UV-B radiation increased the mass loss by 14-19% and the ambient radiation by 9-16% for wheat and maize straws without soil contact after 12 months. Elevated UV-B exposure decreased the decomposition rates of both wheat and maize straws when in contact with soil. Light exposure resulted in decreased O-alkyl carbons and increased alkyl carbons for both the wheat and maize straws compared with no-sunlight control. The difference in soil contact may influence the contribution of photodegradation to the overall straw decomposition process. These results indicate that we must take into account the effects of photodegradation when explaining the mechanisms of straw decomposition in mesic ecosystems.

  11. Balanced conditions or slight mass gain of glaciers in the Lahaul and Spiti region (northern India, Himalaya during the nineties preceded recent mass loss

    Directory of Open Access Journals (Sweden)

    C. Vincent

    2013-04-01

    Full Text Available The volume change of the Chhota Shigri Glacier (India, 32° 20 N, 77° 30' E between 1988 and 2010 has been determined using in situ geodetic measurements. This glacier has experienced only a slight mass loss between 1988 and 2010 (−3.8 ± 2.0 m w.e. (water equivalent corresponding to −0.17 ± 0.09 m w.e. yr−1. Using satellite digital elevation models (DEM differencing and field measurements, we measure a negative mass balance (MB between 1999 and 2010 (−4.8 ± 1.8 m w.e. corresponding to −0.44 ± 0.16 m w.e. yr−1. Thus, we deduce a slightly positive or near-zero MB between 1988 and 1999 (+1.0 ± 2.7 m w.e. corresponding to +0.09 ± 0.24 m w.e. yr−1. Furthermore, satellite DEM differencing reveals that the MB of the Chhota Shigri Glacier (−0.39 ± 0.15 m w.e. yr−1 has been only slightly less negative than the MB of a 2110 km2 glaciarized area in the Lahaul and Spiti region (−0.44 ± 0.09 m w.e. yr−1 during 1999−2011. Hence, we conclude that the ice wastage is probably moderate in this region over the last 22 yr, with near equilibrium conditions during the nineties, and an ice mass loss after. The turning point from balanced to negative mass budget is not known but lies probably in the late nineties and at the latest in 1999. This positive or near-zero MB for Chhota Shigri Glacier (and probably for the surrounding glaciers of the Lahaul and Spiti region during at least part of the 1990s contrasts with a recent compilation of MB data in the Himalayan range that indicated ice wastage since 1975. However, in agreement with this compilation, we confirm more negative balances since the beginning of the 21st century.

  12. Stellar Evolution in NGC 6791: Mass Loss on the Red Giant Branch and the Formation of Low-Mass White Dwarfs

    Science.gov (United States)

    Kalirai, Jasonjot S.; Bergeron, P.; Hansen, Brad M. S.; Kelson, Daniel D.; Reitzel, David B.; Rich, R. Michael; Richer, Harvey B.

    2007-12-01

    We present the first detailed study of the properties (temperatures, gravities, and masses) of the NGC 6791 white dwarf population. This unique stellar system is both one of the oldest (8 Gyr) and most metal-rich ([Fe/H]~+0.4) open clusters in our Galaxy and has a color-magnitude diagram (CMD) that exhibits both a red giant clump and a much hotter extreme horizontal branch. Fitting the Balmer lines of the white dwarfs in the cluster using Keck/LRIS spectra suggests that most of these stars are undermassive, =0.43+/-0.06 Msolar, and therefore could not have formed from canonical stellar evolution involving the helium flash at the tip of the red giant branch. We show that at least 40% of NGC 6791's evolved stars must have lost enough mass on the red giant branch to avoid the flash and therefore did not convert helium into carbon-oxygen in their core. Such increased mass loss in the evolution of the progenitors of these stars is consistent with the presence of the extreme horizontal branch in the CMD. This unique stellar evolutionary channel also naturally explains the recent finding of a very young age (2.4 Gyr) for NGC 6791 from white dwarf cooling theory; helium-core white dwarfs in this cluster will cool ~3 times slower than carbon-oxygen-core stars, and therefore the corrected white dwarf cooling age is in fact >~7 Gyr, consistent with the well-measured main-sequence turnoff age. These results provide direct empirical evidence that mass loss is much more efficient in high-metallicity environments and therefore may be critical in interpreting the ultraviolet upturn in elliptical galaxies. Data presented herein were obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California, and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W. M. Keck Foundation. Based on observations obtained at the

  13. Clinical Significance of Serum Adipokines according to Body Mass Index in Patients with Clinically Localized Prostate Cancer Undergoing Radical Prostatectomy

    Directory of Open Access Journals (Sweden)

    Minyong Kang

    2018-01-01

    Full Text Available Purpose: The aim of this study was to investigate the clinical significance of 7 circulating adipokines according to body mass index (BMI in Korean men with localized prostate cancer (PCa undergoing radical prostatectomy (RP. Materials and Methods: Sixty-two of 65 prospectively enrolled patients with clinically localized PCa who underwent RP between 2015 and 2016 were evaluated. Patients were classified into 2 groups according to their BMI: non-obese (<25 kg/m2 and obese (≥25 kg/m2. The adipokines evaluated were interleukin-2, insulin-like growth factor 1 (IGF-1, chemerin, C-X-C motif chemokine 10, adiponectin, leptin, and resistin. Multivariate logistic regression analysis was used to identify the independent predictors of advanced tumor stage. Results: We found that obese patients with PCa who underwent RP had a higher incidence of tumors with a high Gleason score (≥8, pathological T3 (pT3 stage, and positive extraprostatic extension than patients with a normal BMI. Additionally, patients with obesity showed significantly lower serum adiponectin and higher serum leptin levels, but did not show differences in other adipokines. Multivariate analysis demonstrated that IGF-1 (odds ratio [OR]=1.03 was identified as a predictor of advanced tumor stage (≥pT3 in the overall population. However, only leptin remained an independent predictive factor for advanced tumor stage (≥pT3 (OR=1.15 in patients with obesity. Conclusions: In conclusion, our results indicate that a higher leptin level in obese men can be considered a risk factor for aggressive PCa. This prospective study provides greater insight into the role of circulating adipokines in Korean patients with PCa undergoing RP, particularly in patients with obesity.

  14. Mass loss of Greenland from GRACE, IceSat and CryoSat

    DEFF Research Database (Denmark)

    Forsberg, René; Sørensen, Louise Sandberg; Fredenslund Levinsen, Joanna

    2013-01-01

    CryoSat data over the Greenland Ice Sheet are used to continue elevation height change data over the Greenland ice sheet, following a decade of detailed monitoring of ice sheet changes with GRACE and IceSat. The combination and validation of the different data for measuring changes is quantified...... by using available airborne lidar data from IceBridge and CryoVEx. There is a special challenge of using CryoSat as fill-in between EnviSat and Sentinel-3 for the longterm measurements of surface elevation changes, a key essential climate variable in the ESA Climate Change Initiative. Another challenge...... is the joint utilization of both altimetry and gravity field change measurements for consistent estimates of regional change patterns. In the paper we analyze GRACE, IceSat and CryoSat data since 2003, and present consistent estimates of overall mass changes with average values around -220 GT/year, showing...

  15. Mass fractionation during transonic escape and implications for loss of water from Mars and Venus

    International Nuclear Information System (INIS)

    Zahnle, K.J.; Kasting, J.F.

    1986-01-01

    Hydrodynamic escape of hydrogen from a planetary atmosphere can remove heavier gases as well as hydrogen, provided that the escape rate is sufficiently large. Analytic approximations for the degree of mass fractionation of a trace species during hydrodynamic escape are compared with accurate numerical solutions for the case of transonic outflow. The analytic approximations are most accurate when the ratio of molecular weights of the heavier and lighter constituents is large so that nonlinear terms in the momentum equation for the heavy constituent become small. The simplest analytic formula is readily generalized to the case where a heavy constituent is also a major species. Application of the generalized formula to hypothetical episodes of hydrodynamic escape from Venus and Mars suggests that both hydrogen and oxygen could have escaped; thus, substantial quantities of water may have been lost without the need to oxidize large amounts of the crust. 29 references

  16. Mass loss from the proto-sun: Formation and evolution of the solar nebula

    International Nuclear Information System (INIS)

    Trivedi, B.M.P.

    1984-01-01

    We consider the formation and evolution of the solar nebula in the light of observations of T Tauri stars, oxygen-isotopic anomalies in meteorites, and the mass and angular momentum distribution in the present solar system. It is argued that the solar nebula formed from the mass lost by the proto-Sun. The outflow of initially partially ionized material in the presence of a strong proto-solar magnetic field would lead to the transfer of angular momentum from the central Sun to the outflowing matter. This explains the present angular momentum distribution between the Sun and the planetary system. When the outflowing matter cooled sufficiently, to less than 2000 K, approx. l0 12 cm from the Sun, the material would neutralize, and the magnetic field would then decouple from the outflowing matter. Further motion would be governed by the gravitational field of the proto-Sun, the gas pressure, and the centrifugal force. When these forces balance, the radial flow would stop, and a rotating solar nebula would form. Chemical condensation would occur in the outflowing matter when suitable pressure-temperature conditions would develop. The condensation of the refractory mineral Al 2 O 3 would start at a distance of approx.2 x l0 12 cm from the Sun, where the pressure would be approx. 3 x l0 8 atm, and temperature approx. l450 K. The condensation sequence of other lower temperature minerals would follow this. All the refractory minerals and iron would condense within the orbit of the planet Mercury. All the volatiles would condense before the outflowing matter crossed the asteroid region. The grains would move to the outer part of the nebula along with the outflowing gas

  17. The reversible P2Y12 antagonist ACT-246475 causes significantly less blood loss than ticagrelor at equivalent antithrombotic efficacy in rat.

    Science.gov (United States)

    Rey, Markus; Kramberg, Markus; Hess, Patrick; Morrison, Keith; Ernst, Roland; Haag, Franck; Weber, Edgar; Clozel, Martine; Baumann, Martine; Caroff, Eva; Hubler, Francis; Riederer, Markus A; Steiner, Beat

    2017-10-01

    The P2Y 12 receptor is a validated target for prevention of major adverse cardiovascular events in patients with acute coronary syndrome. The aim of this study was to compare two direct-acting, reversible P2Y 12 antagonists, ACT-246475 and ticagrelor, in a rat thrombosis model by simultaneous quantification of their antithrombotic efficacy and surgery-induced blood loss. Blood flow velocity was assessed in the carotid artery after FeCl 3 -induced thrombus formation using a Doppler flow probe. At the same time, blood loss after surgical wounding of the spleen was quantified. Continuous infusions of ACT-246475 and ticagrelor prevented the injury-induced reduction of blood flow in a dose-dependent manner. High doses of both antagonists normalized blood flow and completely abolished thrombus formation as confirmed by histology. Intermediate doses restored baseline blood flow to ≥65%. However, ACT-246475 caused significantly less increase of blood loss than ticagrelor; the difference in blood loss was 2.6-fold (P ACT-246475 and ticagrelor on vascular tone. At concentrations needed to achieve maximal antithrombotic efficacy, ticagrelor compared with ACT-246475 significantly increased carotid blood flow velocity in vivo (P = 0.003), induced vasorelaxation of precontracted rat femoral arteries, and inhibited contraction of femoral artery induced by electrical field stimulation or by phenylephrine. Overall, ACT-246475 showed a significantly wider therapeutic window than ticagrelor. The absence of vasodilatory effects due to high selectivity of ACT-246475 for P2Y 12 provides potential arguments for the observed safety advantage of ACT-246475 over ticagrelor. © 2017 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.

  18. Evaluation of effect of body mass index and weight loss on survival of patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy

    International Nuclear Information System (INIS)

    Lin, Yu-Hsuan; Chang, Kuo-Ping; Lin, Yaoh-Shiang; Chang, Ting-Shou

    2015-01-01

    Previous studies report body-mass index (BMI) and percent weight loss (WL) to have prognostic significance when treating patients with nasopharyngeal carcinoma (NPC). However, most of these investigations studied patients treated using different radiotherapeutic techniques. We evaluated the predictive effect of these two nutrition-related measurements on therapeutic outcome in NPC patients who only received intensity-modulated radiation therapy (IMRT) as part of their total treatment program. We retrospectively studied NPC patients treated with IMRT from January 2006 to February 2012. Cox proportional hazards was used to test the association of pretreatment BMI (<23 kg/m 2 vs. ≥23 kg/m 2 ) and percent weight loss (≥5 % vs. <5 %) during therapy and related survival rates while controlling for various potential confounders. Eighty-one (34 %) of the 238 patients had BMIs ≥23 kg/m 2 at pretreatment and 150 (63 %) had significant (≥5 %) weight loss. Median follow-up time was 41.71 months; median radiotherapy was 7.46 ± 0.77 weeks. Those with BMIs ≥23 kg/m 2 did not have a better 3-year overall survival (p = 0.672), 3-year disease specific survival (p = 0.341), 3-year locoregional free survival (p = 0.281), or 3-year distant metastatic free survival (p = 0.134). Those with significant WL (≥5 %) did not have worse 3-year clinical endpoints, even after stratifying magnitude of weight loss by BMI category. In sensitivity test, the adjusted hazard ratio remained statistically insignificant using different cutoffs for BMIs and percent weight loss. This study found no significant relationship between BMI and percent weight loss on survival of NPC patients receiving IMRT based therapy. Further studies might want to consider other nutrition related factors as prognostic indicators when studying the correlate between malnutrition and survival in this population. The online version of this article (doi:10.1186/s13014-015-0443-3) contains supplementary material, which

  19. Significant weight loss following clozapine use, how is it possible? A case report and review of published cases and literature relevant to the subject.

    Science.gov (United States)

    Tungaraza, Tongeji E

    2016-10-01

    It has been repeatedly shown that clozapine is more efficacious than other antipsychotics in the management of treatment-resistant schizophrenia. However, clozapine is associated with a number of side effects including weight gain. Antipsychotic-induced weight gain has been linked with a number of untoward events including psychological factors such as stigma and low self-esteem, and physical factors such as metabolic syndromes and untimely death. The mechanism underlying antipsychotic (including clozapine)-induced weight gain is not clearly understood, although it is said to involve several brain areas, several neurotransmitters, neuropeptides and genetic factors. To some individuals however, clozapine use is associated with significant weight loss (13.5-50% of body weight). The observed weight loss in these groups of patients has not been attributed to any underlying diagnosable physical disorders. There have been a handful cases published with this phenomenon, which seems to be contrary to what is expected when clozapine is prescribed. From the currently published cases three groups emerge - those who lost weight simply by taking clozapine, those who lost weight due to improved mental state, engaging in diet and increased exercise, and those for whom weight loss was a sign of a poor response to clozapine. A case of JX who has a diagnosis of schizoaffective disorder is presented. JX lost over 26% of her body weight when she was prescribed clozapine. A detailed review of other published cases is undertaken. The underlying mechanisms involving weight loss are discussed and the implications to clinicians are highlighted. Coordinated studies to examine these groups of patients may provide some insight, not only in the mechanism of clozapine-induced weight loss, but also in the better management of patients with treatment-resistant schizophrenia involving clozapine use.

  20. The evaluation of tissue mass loss in the incision line of prostate with benign hyperplasia performed using holmium laser and cutting electrode.

    Science.gov (United States)

    Szewczyk, Mariusz; Jesionek-Kupnicka, Dorota; Lipiński, Marek Ireneusz; Lipinski, Piotr; Różański, Waldemar

    2014-01-01

    The aim of this study is to compare the changes in the incision line of prostatic adenoma using a monopolar cutting electrode and holmium laser, as well as the assessment of associated tissue mass and volume loss of benign prostatic hyperplasia (BPH). The material used in this study consisted of 74 preparations of prostatic adenoma obtained via open retropubic adenomectomy, with an average volume of 120.7 ml. The material obtained cut in vitro before fixation in formaldehyde. One lobe was cut using holmium laser, the other using a monopolar cutting electrode. After the incision was made, tissue mass and volume loss were evaluated. Thermocoagulation changes in the incision line were examinedunder light microscope. In the case of the holmium laser incision, the average tissue mass loss was 1.73 g, tissue volume loss 3.57 ml and the depth of thermocoagulation was 1.17 mm. When the monopolar cutting electrode was used average tissue mass loss was 0.807 g, tissue volume loss 2.48 ml and the depth of thermocoagulation was 0.19 mm. Where holmium laser was used, it was observed that the layer of tissue with thermocoagulation changes was deeper than in the case of the monopolar cutting electrode. Moreover, it was noticed that holmium laser caused bigger tissue mass and volume loss than the cutting electrode.

  1. Mass

    International Nuclear Information System (INIS)

    Quigg, Chris

    2007-01-01

    In the classical physics we inherited from Isaac Newton, mass does not arise, it simply is. The mass of a classical object is the sum of the masses of its parts. Albert Einstein showed that the mass of a body is a measure of its energy content, inviting us to consider the origins of mass. The protons we accelerate at Fermilab are prime examples of Einsteinian matter: nearly all of their mass arises from stored energy. Missing mass led to the discovery of the noble gases, and a new form of missing mass leads us to the notion of dark matter. Starting with a brief guided tour of the meanings of mass, the colloquium will explore the multiple origins of mass. We will see how far we have come toward understanding mass, and survey the issues that guide our research today.

  2. Short-term combined treatment with liraglutide and metformin leads to significant weight loss in obese women with polycystic ovary syndrome and previous poor response to metformin.

    Science.gov (United States)

    Jensterle Sever, Mojca; Kocjan, Tomaz; Pfeifer, Marija; Kravos, Nika Aleksandra; Janez, Andrej

    2014-03-01

    The effect of metformin on weight reduction in polycystic ovary syndrome (PCOS) is often unsatisfactory. In this study, we investigated the potential add-on effect of treatment with the glucagon-like peptide-1 receptor agonist liraglutide on weight loss in obese nondiabetic women with PCOS who had lost weight during pretreatment with metformin. A total of 40 obese women with PCOS, who had been pretreated with metformin for at least 6 months, participated in a 12-week open-label, prospective study. They were randomized to one of three treatment arms: metformin (MET) arm 1000 mg BID, liraglutide (LIRA) arm 1.2 mg QD s.c., or combined MET 1000 mg BID and LIRA (COMBI) 1.2 mg QD s.c. Lifestyle intervention was not actively promoted. The primary outcome was change in body weight. Thirty six patients (aged 31.3 ± 7.1 years, BMI 37.1 ± 4.6 kg/m²) completed the study: 14 on MET, 11 on LIRA, and 11 on combined treatment. COMBI therapy was superior to LIRA and MET monotherapy in reducing weight, BMI, and waist circumference. Subjects treated with COMBI lost on average 6.5 ± 2.8 kg compared with a 3.8 ± 3.7 kg loss in the LIRA group and a 1.2 ± 1.4 kg loss in the MET group (Pweight loss was stratified: a total of 38% of subjects were high responders who lost ≥5% body weight, 22% of them in the COMBI arm compared with 16 and 0% in the LIRA and MET arm respectively. BMI decreased by 2.4 ± 1.0 in the COMBI arm compared with 1.3 ± 1.3 in LIRA and 0.5 ± 0.5 in the MET arm (Pweight loss. Short-term combined treatment with liraglutide and metformin was associated with significant weight loss and decrease in waist circumference in obese women with PCOS who had previously been poor responders regarding weight reduction on metformin monotherapy.

  3. Optimizing the supply chain of biomass and biogas for a single plant considering mass and energy losses

    DEFF Research Database (Denmark)

    Jensen, Ida Græsted; Münster, Marie; Pisinger, David

    2017-01-01

    plants. In this paper, a mixed integer programming (MIP) model for finding the optimal production and investment plan for a biogas supply chain is presented to ensure better economy for the full chain hopefully stimulating future investments in biogas. The model makes use of step-wise linear functions...... to represent capital and operational expenditures at the biogas plant; considers the chain from the farmer to the end market; and includes changes of mass and energy content along the chain by modeling the losses and gains for all processes in the chain. Biomass inputs are scheduled on a weekly basis whereas...... energy outputs are scheduled on an hourly basis to better capture the changes of energy prices and potentially take advantage of these changes. The model is tested on a case study with co-digestion of straw, sugar beet and manure, considering natural gas, heat, and electricity as end products. The model...

  4. Does the Loss of ARID1A (BAF-250a Expression in Endometrial Clear Cell Carcinomas Have Any Clinicopathologic Significance? A Pilot Assessment

    Directory of Open Access Journals (Sweden)

    Oluwole Fadare, Idris L. Renshaw, Sharon X. Liang

    2012-01-01

    Full Text Available SWI/SNF chromatin-modification complexes use the energy of ATP hydrolysis to remodel nucleosomes and to affect transcription and several cellular processes. Accordingly, their loss of function has been associated with malignant transformation. ARID1A (the expression of whose product, BAF250a, a key complex component, is lost when mutated has recently been identified as a tumor suppressor gene that is mutated in 46-57% of ovarian clear cell carcinoma (CCC. The purposes of this study are to assess the frequency of loss of BAF250a expression in endometrial CCC and whether this loss has any discernable clinicopathologic implications. 34 endometrial carcinomas with a CCC component (including 22 pure CCC, 8 mixed carcinomas with a 10% CCC component, and 4 carcinosarcomas with a CCC epithelial component, were evaluated by immunohistochemistry using a monoclonal antibody directed against the human BAF250a protein. 5 (22.7% of the 22 pure CCC were entirely BAF250a negative, whereas the remainder showed diffuse immunoreactivity. None of 4 carcinosarcomas and only 1 (12.5% of the 8 mixed carcinomas were BAF250a negative. There was no discernable relationship between BAF250a immunoreactivity status and tumor architectural patterns (solid, papillary or tubulocystic areas or cell type (flat, hobnail or polygonal. Of the 22 patients with pure CCC, 14, 2, 3, and 3 were International Federation of Gynecology and Obstetrics stages 1, II, III and IV respectively. Interestingly, all 5 BAF250a negative cases were late stage [stages III or IV] as compared with 1 of 17 BAF250a positive cases (p=0.0002. Thus, 83% (5/6 of all late stage cases were BAF250a [-], as compared with 0 (0% of the 16 early stage (I or II cases (p=.0002. BAF250a negative and positive cases did not show any statistically significant difference regarding patient age and frequency of lymphovascular invasion or myometrial invasion. As may be anticipated from the concentration of late stage cases in

  5. Heat waves imposed during early pod development in soybean (Glycine max) cause significant yield loss despite a rapid recovery from oxidative stress.

    Science.gov (United States)

    Siebers, Matthew H; Yendrek, Craig R; Drag, David; Locke, Anna M; Rios Acosta, Lorena; Leakey, Andrew D B; Ainsworth, Elizabeth A; Bernacchi, Carl J; Ort, Donald R

    2015-08-01

    Heat waves already have a large impact on crops and are predicted to become more intense and more frequent in the future. In this study, heat waves were imposed on soybean using infrared heating technology in a fully open-air field experiment. Five separate heat waves were applied to field-grown soybean (Glycine max) in central Illinois, three in 2010 and two in 2011. Thirty years of historical weather data from Illinois were analyzed to determine the length and intensity of a regionally realistic heat wave resulting in experimental heat wave treatments during which day and night canopy temperatures were elevated 6 °C above ambient for 3 days. Heat waves were applied during early or late reproductive stages to determine whether and when heat waves had an impact on carbon metabolism and seed yield. By the third day of each heat wave, net photosynthesis (A), specific leaf weight (SLW), and leaf total nonstructural carbohydrate concentration (TNC) were decreased, while leaf oxidative stress was increased. However, A, SLW, TNC, and measures of oxidative stress were no different than the control ca. 12 h after the heat waves ended, indicating rapid physiological recovery from the high-temperature stress. That end of season seed yield was reduced (~10%) only when heat waves were applied during early pod developmental stages indicates the yield loss had more to do with direct impacts of the heat waves on reproductive process than on photosynthesis. Soybean was unable to mitigate yield loss after heat waves given during late reproductive stages. This study shows that short high-temperature stress events that reduce photosynthesis and increase oxidative stress resulted in significant losses to soybean production in the Midwest, U.S. The study also suggests that to mitigate heat wave-induced yield loss, soybean needs improved reproductive and photosynthetic tolerance to high but increasingly common temperatures. Published 2015. This article is a U.S. Government work and is

  6. Sporadic mass loss, spin-down, and element redistribution in young disk galaxies

    International Nuclear Information System (INIS)

    Charlton, J.C.; Salpeter, E.E.

    1989-01-01

    Violent conditions in young spiral disks may be conducive to the high-velocity ejection of large blobs of material powered by the concerted action of supernovae. Using explicit numerical Monte Carlo models, treating ejected bobs as galactic cannonballs traveling with little interaction through the corona, several important consequences for galactic evolution are found. Preferential escape from the galaxy or objects with high specific angular momenta lead to a significant spin-down of the disk. In addition, this process may contribute to the production of an exponential column density distribution, and a metallicity gradient. The models predict a reversal in the sign of the metallicity gradient at large radii because the metal-rich objects that return to such a low column density region suffer relatively little dilution. 39 refs

  7. Intranasal insulin influences the olfactory performance of patients with smell loss, dependent on the body mass index: A pilot study.

    Science.gov (United States)

    Schöpf, V; Kollndorfer, K; Pollak, M; Mueller, C A; Freiherr, J

    2015-12-01

    The application of intranasal insulin in healthy humans has been linked to improved memory function, reduced food intake, and increased olfactory thresholds. There has also been some correlation between the morbidities associated with central nervous system (CNS) insulin resistance, such as type II diabetes mellitus, Alzheimer's disease, obesity, and impaired odour recognition. Given that impaired odour recognition is an important component of olfactory performance, mechanisms that govern these effects may account for impaired olfactory functions in anosmic patients. Ten patients with post-infectious olfactory loss received intranasal administration of 40 IU insulin or a placebo solution, as well as olfactory performance tests before and after administration. When administered insulin, patients exhibited an immediate performance improvement with regard to olfactory sensitivity and olfactory intensity ratings. In addition, more odours were correctly identified. Furthermore, an improvement in the odour identification task was detected in patients with higher body mass index. Results of this pilot study shed light on the link between cerebral insulin level and an impaired sense of smell. This research line might provide a better understanding of olfactory loss in relation to eating and dietary behavior, and could offer opportunities to develop faster therapeutic intervention for patients with olfactory dysfunction.

  8. Gender differences in body mass index, body weight perception and weight loss strategies among undergraduates in Universiti Malaysia Sarawak.

    Science.gov (United States)

    Kuan, P X; Ho, H L; Shuhaili, M S; Siti, A A; Gudum, H R

    2011-04-01

    This study was carried out among undergraduate students in Universiti Malaysia Sarawak with the objective of examining gender differences in body mass index (BMI), body weight perception, eating attitudes and weightloss strategies. Subjects consisted of 600 undergraduates (300 males and 300 females) recruited from the various faculties between September 2008 until mid-November 2008. The Original Figure Rating Scale: Body Weight Perception, Body Shape Questionnaire (BSQ) and Eating Attitudes Test-26 (EAT-26) were used as assessment tools. Overall, 52.8% of students had normal BMI, with approximately an equal number of both sexes. More males than females were overweight (33.7%), while more females were underweight (25.3%). Males were more likely to perceive themselves as overweight, and fail to see themselves as underweight. More than half of the females preferred their ideal figure to be underweight, whereas about 30% males chose an overweight figure as their ideal model. Females were generally more concerned about body weight, body shape and eating than males. They diet more frequently, had self-induced vomiting, and used laxatives and exercise as their weight-loss strategies. Issues pertaining to body weight perception, eating attitudes and weight-loss strategies exist with differences among male and female undergraduates. Thus, in order to correct misperceptions among young adults, a more tailored intervention programme and more in-depth studies into the various factors involved are required.

  9. The kinetic of mass loss of grades A and B of melted TNT by isothermal and non-isothermal gravimetric methods

    Directory of Open Access Journals (Sweden)

    Hamid Reza Pouretedal

    2018-04-01

    Full Text Available The kinetic and activation energy of mass loss of two grades of melted TNT explosive, grade A and grade B, with freezing points of 80.57 and 78.15 °C, respectively, were studied by isothermal and non-isothermal gravimetric methods. In isothermal method, the mass loss of samples in containers of glass and aluminum was followed in temperatures of 80, 90 and 100 °C. The kinetic of the mass loss of the samples in the aluminum container was higher than the kinetic of it in the glass container that can be related to the effects of heat transfer and catalytic of aluminum metal. Also, the presence of impurities in grade B was due to increasing of kinetic of mass loss of it versus grade A. The non-isothermal curves were obtained in range of 30–330 °C at heating rates of 10, 15 and 20 °C⋅min−1. The TG/DTG data were used for determination of activation energy (Ea of mass loss of TNT samples upon degradation by using Ozawa, Kissinger, Ozawa-Flynn-Wall (OFW and Kissinger-Akahira-Sunose (KAS methods as model free methods. The activation energies of grades of A and B of TNT was obtained 99–120 and 66–70 kJ mol−1, respectively. The lower values of activation energy of the degradation reaction of grade B confirm the effect of impurities in the kinetics of mass loss of this grade. Keywords: TNT, Isothermal, Non-isothermal, Kinetic, Mass loss

  10. SEA-LEVEL RISE. Sea-level rise due to polar ice-sheet mass loss during past warm periods.

    Science.gov (United States)

    Dutton, A; Carlson, A E; Long, A J; Milne, G A; Clark, P U; DeConto, R; Horton, B P; Rahmstorf, S; Raymo, M E

    2015-07-10

    Interdisciplinary studies of geologic archives have ushered in a new era of deciphering magnitudes, rates, and sources of sea-level rise from polar ice-sheet loss during past warm periods. Accounting for glacial isostatic processes helps to reconcile spatial variability in peak sea level during marine isotope stages 5e and 11, when the global mean reached 6 to 9 meters and 6 to 13 meters higher than present, respectively. Dynamic topography introduces large uncertainties on longer time scales, precluding robust sea-level estimates for intervals such as the Pliocene. Present climate is warming to a level associated with significant polar ice-sheet loss in the past. Here, we outline advances and challenges involved in constraining ice-sheet sensitivity to climate change with use of paleo-sea level records. Copyright © 2015, American Association for the Advancement of Science.

  11. O Star Wind Mass-Loss Rates and Shock Physics from X-ray Line Profiles in Archival XMM RGS Data

    Science.gov (United States)

    Cohen, David

    O stars are characterized by their dense, supersonic stellar winds. These winds are the site of X-ray emission from shock-heated plasma. By analyzing high-resolution X-ray spectra of these O stars, we can learn about the wind-shock heating and X-ray production mechanism. But in addition, the X-rays can also be used to measure the mass-loss rate of the stellar wind, which is a key observational quantity whose value affects stellar evolution and energy, momentum, and mass input to the Galactic interstellar medium. We make this X-ray based mass-loss measurement by analyzing the profile shapes of the X-ray emission lines observed at high resolution with the Chandra and XMM-Newton grating spectrometers. One advantage of our method is that it is insensitive to small-scale clumping that affects density-squared diagnostics. We are applying this analysis technique to O stars in the Chandra archive, and are finding mass-loss rates lower than those traditionally assumed for these O stars, and in line with more recent independent determinations that do account for clumping. By extending this analysis to the XMM RGS data archive, we will make significant contributions to the understanding of both X-ray production in O stars and to addressing the issue of the actual mass-loss rates of O stars. The XMM RGS data archive provides several extensions and advantages over the smaller Chandra HETGS archive: (1) there are roughly twice as many O and early B stars in the XMM archive; (2) the longer wavelength response of the RGS provides access to diagnostically important lines of nitrogen and carbon; (3) the very long, multiple exposures of zeta Pup provide the opportunity to study this canonical O supergiant's X-ray spectrum in unprecedented detail, including looking at the time variability of X-ray line profiles. Our research team has developed a sophisticated empirical line profile model as well as a computational infrastructure for fitting the model to high-resolution X-ray spectra

  12. HST/WFC3 OBSERVATIONS OF LOW-MASS GLOBULAR CLUSTERS AM 4 AND PALOMAR 13: PHYSICAL PROPERTIES AND IMPLICATIONS FOR MASS LOSS

    Energy Technology Data Exchange (ETDEWEB)

    Hamren, Katherine M.; Smith, Graeme H.; Guhathakurta, Puragra [Department of Astronomy and Astrophysics, University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 (United States); Dolphin, Andrew E. [Raytheon, 1151 East Hermans Road, Tucson, AZ 85756 (United States); Weisz, Daniel R. [Department of Astronomy, Box 351580, University of Washington, Seattle, WA 98195 (United States); Rajan, Abhijith [School of Earth and Space Exploration, Arizona State University, 781 East Terrace Road, Tempe, AZ 85287 (United States); Grillmair, Carl J., E-mail: khamren@ucolick.org [Spitzer Science Center, California Institute of Technology, Mail Stop 220-6, Pasadena, CA 91125 (United States)

    2013-11-01

    We investigate the loss of low-mass stars in two of the faintest globular clusters known, AM 4 and Palomar 13 (Pal 13), using HST/WFC3 F606W and F814W photometry. To determine the physical properties of each cluster—age, mass, metallicity, extinction, and present day mass function (MF)—we use the maximum likelihood color-magnitude diagram (CMD) fitting program MATCH and the Dartmouth, Padova, and BaSTI stellar evolution models. For AM 4, the Dartmouth models provide the best match to the CMD and yield an age of >13 Gyr, metallicity log Z/Z {sub ☉} = –1.68 ± 0.08, a distance modulus (m – M) {sub V} = 17.47 ± 0.03, and reddening A{sub V} = 0.19 ± 0.02. For Pal 13 the Dartmouth models give an age of 13.4 ± 0.5 Gyr, log Z/Z {sub ☉} = –1.55 ± 0.06, (m – M) {sub V} = 17.17 ± 0.02, and A{sub V} = 0.43 ± 0.01. We find that the systematic uncertainties due to choice in assumed stellar model greatly exceed the random uncertainties, highlighting the importance of using multiple stellar models when analyzing stellar populations. Assuming a single-sloped power-law MF, we find that AM 4 and Pal 13 have spectral indices α = +0.68 ± 0.34 and α = –1.67 ± 0.25 (where a Salpeter MF has α = +1.35), respectively. Comparing our derived slopes with literature measurements of cluster integrated magnitude (M{sub V} ) and MF slope indicates that AM 4 is an outlier. Its MF slope is substantially steeper than clusters of comparable luminosity, while Pal 13 has an MF in line with the general trend. We discuss both primordial and dynamical origins for the unusual MF slope of AM 4 and tentatively favor the dynamical scenario. However, MF slopes of more low luminosity clusters are needed to verify this hypothesis.

  13. HST/WFC3 OBSERVATIONS OF LOW-MASS GLOBULAR CLUSTERS AM 4 AND PALOMAR 13: PHYSICAL PROPERTIES AND IMPLICATIONS FOR MASS LOSS

    International Nuclear Information System (INIS)

    Hamren, Katherine M.; Smith, Graeme H.; Guhathakurta, Puragra; Dolphin, Andrew E.; Weisz, Daniel R.; Rajan, Abhijith; Grillmair, Carl J.

    2013-01-01

    We investigate the loss of low-mass stars in two of the faintest globular clusters known, AM 4 and Palomar 13 (Pal 13), using HST/WFC3 F606W and F814W photometry. To determine the physical properties of each cluster—age, mass, metallicity, extinction, and present day mass function (MF)—we use the maximum likelihood color-magnitude diagram (CMD) fitting program MATCH and the Dartmouth, Padova, and BaSTI stellar evolution models. For AM 4, the Dartmouth models provide the best match to the CMD and yield an age of >13 Gyr, metallicity log Z/Z ☉ = –1.68 ± 0.08, a distance modulus (m – M) V = 17.47 ± 0.03, and reddening A V = 0.19 ± 0.02. For Pal 13 the Dartmouth models give an age of 13.4 ± 0.5 Gyr, log Z/Z ☉ = –1.55 ± 0.06, (m – M) V = 17.17 ± 0.02, and A V = 0.43 ± 0.01. We find that the systematic uncertainties due to choice in assumed stellar model greatly exceed the random uncertainties, highlighting the importance of using multiple stellar models when analyzing stellar populations. Assuming a single-sloped power-law MF, we find that AM 4 and Pal 13 have spectral indices α = +0.68 ± 0.34 and α = –1.67 ± 0.25 (where a Salpeter MF has α = +1.35), respectively. Comparing our derived slopes with literature measurements of cluster integrated magnitude (M V ) and MF slope indicates that AM 4 is an outlier. Its MF slope is substantially steeper than clusters of comparable luminosity, while Pal 13 has an MF in line with the general trend. We discuss both primordial and dynamical origins for the unusual MF slope of AM 4 and tentatively favor the dynamical scenario. However, MF slopes of more low luminosity clusters are needed to verify this hypothesis

  14. Weight loss of 5% or more predicts loss of fat-free mass during palliative chemotherapy in patients with advanced cancer: a pilot study

    NARCIS (Netherlands)

    Buskermolen, Susanne; Langius, Jacqueline A. E.; Kruizenga, Hinke M.; Ligthart-Melis, Gerdien C.; Heymans, Martijn W.; Verheul, Henk M. W.

    2012-01-01

    The cutoff value of critical weight loss is still subject of discussion. In this pilot study, we investigated whether ≥ 5% weight loss in the past year predicts changes in nutritional status in patients with advanced cancer during treatment with palliative chemotherapy. In 20 patients with advanced

  15. Weight Loss Composition is One-Fourth Fat-Free Mass: A Critical Review and Critique of This Widely Cited Rule

    Science.gov (United States)

    Heymsfield, Steven B.; Cristina Gonzalez, M. C.; Shen, Wei; Redman, Leanne; Thomas, Diana

    2014-01-01

    Maximizing fat loss while preserving lean tissue mass and function is a central goal of modern obesity treatments. A widely cited rule guiding expected loss of lean tissue as fat-free mass (FFM) states that approximately one-fourth of weight loss will be FFM (i.e., ΔFFM/ΔWeight = ~0.25) with the remaining three-fourths fat mass. This review examines the dynamic relations between FFM, fat mass, and weight changes that follow induction of negative energy balance with hypocaloric dieting and/or exercise. Historical developments in the field are traced with the “Quarter FFM Rule” used as a framework to examine evolving concepts on obesity tissue, excess weight, and what is often cited as “Forbes’ Rule”. Temporal effects in the fractional contribution of FFM to changes in body weight are examined as are lean tissue moderating effects such as aging, inactivity, and exercise that frequently accompany structured low-calorie diet weight loss protocols. Losses of lean tissue with dieting typically tend to be small, raising questions about study design, power, and applied measurement method reliability. Our review elicits important questions related to the fractional loss of lean tissues with dieting and provides a foundation for future research on this topic. PMID:24447775

  16. MTOR signaling and ubiquitin-proteosome gene expression in the preservation of fat free mass following high protein, calorie restricted weight loss

    Directory of Open Access Journals (Sweden)

    McIver Cassandra M

    2012-09-01

    Full Text Available Abstract Caloric restriction is one of the most efficient ways to promote weight loss and is known to activate protective metabolic pathways. Frequently reported with weight loss is the undesirable consequence of fat free (lean muscle mass loss. Weight loss diets with increased dietary protein intake are popular and may provide additional benefits through preservation of fat free mass compared to a standard protein, high carbohydrate diet. However, the precise mechanism by which a high protein diet may mitigate dietary weight loss induced reductions in fat free mass has not been fully elucidated. Maintenance of fat free mass is dependent upon nutrient stimulation of protein synthesis via the mTOR complex, although during caloric restriction a decrease (atrophy in skeletal muscle may be driven by a homeostatic shift favouring protein catabolism. This review evaluates the relationship between the macronutrient composition of calorie restricted diets and weight loss using metabolic indicators. Specifically we evaluate the effect of increased dietary protein intake and caloric restricted diets on gene expression in skeletal muscle, particularly focusing on biosynthesis, degradation and the expression of genes in the ubiquitin-proteosome (UPP and mTOR signaling pathways, including MuRF-1, MAFbx/atrogin-1, mTORC1, and S6K1.

  17. [Contribution of soil fauna to the mass loss of Betula albosinensis leaf litter at early decomposition stage of subalpine forest litter in western Sichuan].

    Science.gov (United States)

    Xia, Lei; Wu, Fu-Zhong; Yang, Wan-Qin; Tan, Bo

    2012-02-01

    In order to quantify the contribution of soil fauna to the decomposition of birch (Betula albosinensis) leaf litter in subalpine forests in western Sichuan of Southwest China during freeze-thaw season, a field experiment with different mesh sizes (0.02, 0.125, 1 and 3 mm) of litterbags was conducted in a representative birch-fir (Abies faxoniana) forest to investigate the mass loss rate of the birch leaf litter from 26 October, 2010 to 18 April, 2011, and the contributions of micro-, meso- and macro-fauna to the decomposition of the leaf litter. Over the freeze-thaw season, 11.8%, 13.2%, 15.4% and 19.5% of the mass loss were detected in the litterbags with 0.02, 0. 125, 1 and 3 mm mesh sizes, respectively. The total contribution of soil fauna to the litter decomposition accounted for 39.5% of the mass loss, and the taxa and individual relative density of the soil fauna in the litterbags had the similar variation trend with that of the mass loss rate. The contribution rate of soil fauna to the leaf litter mass loss showed the order of micro- soil fauna played an important role in the litter decomposition in subalpine forests of western Sichuan during freeze-thaw season.

  18. TNFα blockade for inflammatory rheumatic diseases is associated with a significant gain in android fat mass and has varying effects on adipokines: a 2-year prospective study.

    Science.gov (United States)

    Toussirot, Éric; Mourot, Laurent; Dehecq, Barbara; Wendling, Daniel; Grandclément, Émilie; Dumoulin, Gilles

    2014-04-01

    To evaluate the long-term consequences of TNFα inhibitors on body composition and fat distribution, as well as changes in serum adipokines in patients with rheumatoid arthritis (RA) or ankylosing spondylitis (AS). Eight patients with RA and twelve with AS requiring a TNFα inhibitor were prospectively followed for 2 years. Body composition was evaluated by dual X-ray absorptiometry and included measurements of total fat mass, lean mass, fat in the gynoid and android regions, and visceral fat. Serum leptin, total and high molecular weight (HMW) adiponectin, resistin, and ghrelin were also assessed. There was a significant gain in body mass index (p = 0.05) and a tendency for weight (p = 0.07), android fat (p = 0.07), and visceral fat (p = 0.059) increase in patients with RA, while in AS, total fat mass significantly increased (p = 0.02) with a parallel weight gain (p = 0.07). When examining the whole population of patients, we observed after 2 years a significant increase in body weight (+1.9%; p = 0.003), body mass index (+2.5%; p = 0.004), total fat mass (+11.1%; p = 0.007), and fat in the android region (+18.3%; p = 0.02). There was a substantial, albeit nonsignificant gain in visceral fat (+24.3%; p = 0.088). Lean mass and gynoid fat were not modified. No major changes were observed for serum leptin, total adiponectin, and ghrelin, while HMW adiponectin and the HMW/total adiponectin ratio tended to decrease (-15.2%, p = 0.057 and -9.3%, p = 0.067, respectively). Resistin decreased significantly (-22.4%, p = 0.01). Long-term TNFα inhibition in RA and AS is associated with a significant gain in fat mass, with a shift to the android (visceral) region. This fat redistribution raises questions about its influence on the cardiovascular profile of patients receiving these treatments.

  19. Low-fat, high-carbohydrate (low-glycaemic index) diet induces weight loss and preserves lean body mass in obese healthy subjects: results of a 24-week study.

    Science.gov (United States)

    Bahadori, B; Yazdani-Biuki, B; Krippl, P; Brath, H; Uitz, E; Wascher, T C

    2005-05-01

    The traditional treatment for obesity which is based on a reduced caloric diet has only been partially successful. Contributing factors are not only a poor long-term dietary adherence but also a significant loss of lean body mass and subsequent reduction in energy expenditure. Both low-fat, high-carbohydrate diets and diets using low-glycaemic index (GI) foods are capable of inducing modest weight loss without specific caloric restriction. The purpose of this study was to investigate the feasibility and medium-term effect of a low-fat diet with high (low GI) carbohydrates on weight loss, body composition changes and dietary compliance. Obese patients were recruited from two obesity outpatient clinics. Subjects were given advise by a dietician, then they attended biweekly for 1-hour group meetings. Bodyweight and body composition were measured at baseline and after 24 weeks. One hundred and nine (91%) patients completed the study; after 24 weeks the average weight loss was 8.9 kg (98.6 vs. 89.7 kg; p fat mass (42.5 vs. 36.4 kg; p vs. 53.3 kg; p low-fat, low-GI diet led to a significant reduction of fat mass; adherence to the diet was very good. Our results suggest that such a diet is feasible and should be evaluated in randomized controlled trials.

  20. Mono-, di- and trimethylated homologues of isoprenoid tetraether lipid cores in archaea and environmental samples: mass spectrometric identification and significance.

    Science.gov (United States)

    Knappy, Chris; Barillà, Daniela; Chong, James; Hodgson, Dominic; Morgan, Hugh; Suleman, Muhammad; Tan, Christine; Yao, Peng; Keely, Brendan

    2015-12-01

    Higher homologues of widely reported C(86) isoprenoid diglycerol tetraether lipid cores, containing 0-6 cyclopentyl rings, have been identified in (hyper)thermophilic archaea, representing up to 21% of total tetraether lipids in the cells. Liquid chromatography-tandem mass spectrometry confirms that the additional carbon atoms in the C(87-88) homologues are located in the etherified chains. Structures identified include dialkyl and monoalkyl ('H-shaped') tetraethers containing C(40-42) or C(81-82) hydrocarbons, respectively, many representing novel compounds. Gas chromatography-mass spectrometric analysis of hydrocarbons released from the lipid cores by ether cleavage suggests that the C(40) chains are biphytanes and the C(41) chains 13-methylbiphytanes. Multiple isomers, having different chain combinations, were recognised among the dialkyl lipids. Methylated tetraethers are produced by Methanothermobacter thermautotrophicus in varying proportions depending on growth conditions, suggesting that methylation may be an adaptive mechanism to regulate cellular function. The detection of methylated lipids in Pyrobaculum sp. AQ1.S2 and Sulfolobus acidocaldarius represents the first reported occurrences in Crenarchaeota. Soils and aquatic sediments from geographically distinct mesotemperate environments that were screened for homologues contained monomethylated tetraethers, with di- and trimethylated structures being detected occasionally. The structural diversity and range of occurrences of the C(87-89) tetraethers highlight their potential as complementary biomarkers for archaea in natural environments. Copyright © 2015 John Wiley & Sons, Ltd.

  1. An Accurate Mass Determination for Kepler-1655b, a Moderately Irradiated World with a Significant Volatile Envelope

    Science.gov (United States)

    Haywood, Raphaëlle D.; Vanderburg, Andrew; Mortier, Annelies; Giles, Helen A. C.; López-Morales, Mercedes; Lopez, Eric D.; Malavolta, Luca; Charbonneau, David; Collier Cameron, Andrew; Coughlin, Jeffrey L.; Dressing, Courtney D.; Nava, Chantanelle; Latham, David W.; Dumusque, Xavier; Lovis, Christophe; Molinari, Emilio; Pepe, Francesco; Sozzetti, Alessandro; Udry, Stéphane; Bouchy, François; Johnson, John A.; Mayor, Michel; Micela, Giusi; Phillips, David; Piotto, Giampaolo; Rice, Ken; Sasselov, Dimitar; Ségransan, Damien; Watson, Chris; Affer, Laura; Bonomo, Aldo S.; Buchhave, Lars A.; Ciardi, David R.; Fiorenzano, Aldo F.; Harutyunyan, Avet

    2018-05-01

    We present the confirmation of a small, moderately irradiated (F = 155 ± 7 F ⊕) Neptune with a substantial gas envelope in a P = 11.8728787 ± 0.0000085 day orbit about a quiet, Sun-like G0V star Kepler-1655. Based on our analysis of the Kepler light curve, we determined Kepler-1655b’s radius to be 2.213 ± 0.082 R ⊕. We acquired 95 high-resolution spectra with Telescopio Nazionale Galileo/HARPS-N, enabling us to characterize the host star and determine an accurate mass for Kepler-1655b of 5.0{+/- }2.83.1 {M}\\oplus via Gaussian-process regression. Our mass determination excludes an Earth-like composition with 98% confidence. Kepler-1655b falls on the upper edge of the evaporation valley, in the relatively sparsely occupied transition region between rocky and gas-rich planets. It is therefore part of a population of planets that we should actively seek to characterize further.

  2. Chronic Alcohol Abuse Leads to Low Bone Mass with No General Loss of Bone Structure or Bone Mechanical Strength

    DEFF Research Database (Denmark)

    Ulhøi, Maiken Parm; Meldgaard, Karoline; Steiniche, Torben

    2017-01-01

    Chronic alcohol abuse (CAA) has deleterious effects on skeletal health. This study examined the impact of CAA on bone with regard to bone density, structure, and strength. Bone specimens from 42 individuals with CAA and 42 individuals without alcohol abuse were obtained at autopsy. Dual-energy X......-ray absorptiometry (DEXA), compression testing, ashing, and bone histomorphometry were performed. Individuals with CAA had significantly lower bone mineral density (BMD) in the femoral neck and significantly lower bone volume demonstrated by thinner trabeculae, decreased extent of osteoid surfaces, and lower mean...... wall thickness of trabecular osteons compared to individuals without alcohol abuse. No significant difference was found for bone strength and structure. Conclusion: CAA leads to low bone mass due to a decrease in bone formation but with no destruction of bone architecture nor a decrease in bone...

  3. The clinical significance of isolated loss of lordosis on cervical spine computed tomography in blunt trauma patients: a prospective evaluation of 1,007 patients.

    Science.gov (United States)

    Mejaddam, Ali Y; Kaafarani, Haytham M A; Ramly, Elie P; Avery, Laura L; Yeh, Dante D; King, David R; de Moya, Marc A; Velmahos, George C

    2015-11-01

    A negative computed tomographic (CT) scan may be used to rule out cervical spine (c-spine) injury after trauma. Loss of lordosis (LOL) is frequently found as the only CT abnormality. We investigated whether LOL should preclude c-spine clearance. All adult trauma patients with isolated LOL at our Level I trauma center (February 1, 2011 to May 31, 2012) were prospectively evaluated. The primary outcome was clinically significant injury on magnetic resonance imaging (MRI), flexion-extension views, and/or repeat physical examination. Of 3,333 patients (40 ± 17 years, 60% men) with a c-spine CT, 1,007 (30%) had isolated LOL. Among 841 patients with a Glasgow Coma Scale score of 15, no abnormalities were found on MRI, flexion-extension views, and/or repeat examinations, and all collars were removed. Among 166 patients with Glasgow Coma Scale less than 15, 3 (.3%) had minor abnormal MRI findings but no clinically significant injury. Isolated LOL on c-spine CT is not associated with a clinically significant injury and should not preclude c-spine clearance. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. Brief Communication: Upper Air Relaxation in RACMO2 Significantly Improves Modelled Interannual Surface Mass Balance Variability in Antarctica

    Science.gov (United States)

    van de Berg, W. J.; Medley, B.

    2016-01-01

    The Regional Atmospheric Climate Model (RACMO2) has been a powerful tool for improving surface mass balance (SMB) estimates from GCMs or reanalyses. However, new yearly SMB observations for West Antarctica show that the modelled interannual variability in SMB is poorly simulated by RACMO2, in contrast to ERA-Interim, which resolves this variability well. In an attempt to remedy RACMO2 performance, we included additional upper-air relaxation (UAR) in RACMO2. With UAR, the correlation to observations is similar for RACMO2 and ERA-Interim. The spatial SMB patterns and ice-sheet-integrated SMB modelled using UAR remain very similar to the estimates of RACMO2 without UAR. We only observe an upstream smoothing of precipitation in regions with very steep topography like the Antarctic Peninsula. We conclude that UAR is a useful improvement for regional climate model simulations, although results in regions with steep topography should be treated with care.

  5. A drop in the pond: the effect of rapid mass-loss on the dynamics and interaction rate of collisionless particles

    Science.gov (United States)

    Penoyre, Zephyr; Haiman, Zoltán

    2018-01-01

    In symmetric gravitating systems experiencing rapid mass-loss, particle orbits change almost instantaneously, which can lead to the development of a sharply contoured density profile, including singular caustics for collisionless systems. This framework can be used to model a variety of dynamical systems, such as accretion discs following a massive black hole merger and dwarf galaxies following violent early star formation feedback. Particle interactions in the high-density peaks seem a promising source of observable signatures of these mass-loss events (i.e. a possible EM counterpart for black hole mergers or strong gamma-ray emission from dark matter annihilation around young galaxies), because the interaction rate depends on the square of the density. We study post-mass-loss density profiles, both analytic and numerical, in idealized cases and present arguments and methods to extend to any general system. An analytic derivation is presented for particles on Keplerian orbits responding to a drop in the central mass. We argue that this case, with initially circular orbits, gives the most sharply contoured profile possible. We find that despite the presence of a set of singular caustics, the total particle interaction rate is reduced compared to the unperturbed system; this is a result of the overall expansion of the system dominating over the steep caustics. Finally, we argue that this result holds more generally, and the loss of central mass decreases the particle interaction rate in any physical system.

  6. Intermittent Fasting Promotes Fat Loss With Lean Mass Retention, Increased Hypothalamic Norepinephrine Content, and Increased Neuropeptide Y Gene Expression in Diet-Induced Obese Male Mice.

    Science.gov (United States)

    Gotthardt, Juliet D; Verpeut, Jessica L; Yeomans, Bryn L; Yang, Jennifer A; Yasrebi, Ali; Roepke, Troy A; Bello, Nicholas T

    2016-02-01

    Clinical studies indicate alternate-day, intermittent fasting (IMF) protocols result in meaningful weight loss in obese individuals. To further understand the mechanisms sustaining weight loss by IMF, we investigated the metabolic and neural alterations of IMF in obese mice. Male C57/BL6 mice were fed a high-fat diet (HFD; 45% fat) ad libitum for 8 weeks to promote an obese phenotype. Mice were divided into four groups and either maintained on ad libitum HFD, received alternate-day access to HFD (IMF-HFD), and switched to ad libitum low-fat diet (LFD; 10% fat) or received IMF of LFD (IMF-LFD). After 4 weeks, IMF-HFD (∼13%) and IMF-LFD (∼18%) had significantly lower body weights than the HFD. Body fat was also lower (∼40%-52%) in all diet interventions. Lean mass was increased in the IMF-LFD (∼12%-13%) compared with the HFD and IMF-HFD groups. Oral glucose tolerance area under the curve was lower in the IMF-HFD (∼50%), whereas the insulin tolerance area under the curve was reduced in all diet interventions (∼22%-42%). HPLC measurements of hypothalamic tissue homogenates indicated higher (∼55%-60%) norepinephrine (NE) content in the anterior regions of the medial hypothalamus of IMF compared with the ad libitum-fed groups, whereas NE content was higher (∼19%-32%) in posterior regions in the IMF-LFD group only. Relative gene expression of Npy in the arcuate nucleus was increased (∼65%-75%) in IMF groups. Our novel findings indicate that intermittent fasting produces alterations in hypothalamic NE and neuropeptide Y, suggesting the counterregulatory processes of short-term weight loss are associated with an IMF dietary strategy.

  7. The Colorado Ultraviolet Transit Experiment (CUTE): a dedicated cubesat mission for the study of exoplanetary mass loss and magnetic fields

    Science.gov (United States)

    Fleming, Brian T.; France, Kevin; Nell, Nicholas; Kohnert, Richard; Pool, Kelsey; Egan, Arika; Fossati, Luca; Koskinen, Tommi; Vidotto, Aline A.; Hoadley, Keri; Desert, Jean-Michel; Beasley, Matthew; Petit, Pascal

    2017-08-01

    The Colorado Ultraviolet Transit Experiment (CUTE) is a near-UV (2550 - 3300 Å) 6U cubesat mission designed to monitor transiting hot Jupiters to quantify their atmospheric mass loss and magnetic fields. CUTE will probe both atomic (Mg and Fe) and molecular (OH) lines for evidence of enhanced transit absorption, and to search for evidence of early ingress due to bow shocks ahead of the planet's orbital motion. As a dedicated mission, CUTE will observe > 60 spectroscopic transits of hot Jupiters over a nominal seven month mission. This represents the equivalent of > 700 orbits of the only other instrument capable of these measurements, the Hubble Space Telescope. CUTE efficiently utilizes the available cubesat volume by means of an innovative optical design to achieve a projected effective area of ˜ 22 cm2 , low instrumental background, and a spectral resolving power of R ˜ 3000 over the entire science bandpass. These performance characteristics enable CUTE to discern a transit depth of motivation and expected results, and an overview of the projected fabrication, calibration and launch timeline.

  8. Colorado Ultraviolet Transit Experiment: a dedicated CubeSat mission to study exoplanetary mass loss and magnetic fields

    Science.gov (United States)

    Fleming, Brian T.; France, Kevin; Nell, Nicholas; Kohnert, Richard; Pool, Kelsey; Egan, Arika; Fossati, Luca; Koskinen, Tommi; Vidotto, Aline A.; Hoadley, Keri; Desert, Jean-Michel; Beasley, Matthew; Petit, Pascal M.

    2018-01-01

    The Colorado Ultraviolet Transit Experiment (CUTE) is a near-UV (2550 to 3300 Å) 6U CubeSat mission designed to monitor transiting hot Jupiters to quantify their atmospheric mass loss and magnetic fields. CUTE will probe both atomic (Mg and Fe) and molecular (OH) lines for evidence of enhanced transit absorption, and to search for evidence of early ingress due to bow shocks ahead of the planet's orbital motion. As a dedicated mission, CUTE will observe ≳100 spectroscopic transits of hot Jupiters over a nominal 7-month mission. This represents the equivalent of >700 orbits of the only other instrument capable of these measurements, the Hubble Space Telescope. CUTE efficiently utilizes the available CubeSat volume by means of an innovative optical design to achieve a projected effective area of ˜28 cm2, low instrumental background, and a spectral resolving power of R˜3000 over the primary science bandpass. These performance characteristics enable CUTE to discern transit depths between 0.1% and 1% in individual spectral absorption lines. We present the CUTE optical and mechanical design, a summary of the science motivation and expected results, and an overview of the projected fabrication, calibration, and launch timeline.

  9. Titanium Mass-balance Analysis of Paso Robles Soils: Elemental Gains and Losses as Affected by Acid Alteration Fluids

    Science.gov (United States)

    Sutter, Brad; Ming, Douglas W.

    2010-01-01

    The Columbia Hills soils have been exposed to aqueous alteration in alkaline [1] as well as acid conditions [2,3]. The Paso Robles class soils are bright soils that possess the highest S concentration of any soil measured on Mars [2]. Ferric-sulfate detection by Moessbauer analysis indicated that acid solutions were involved in forming these soils [4]. These soils are proposed to have formed by alteration of nearby rock by volcanic hydrothermal or fumarolic activity. The Paso Robles soils consist of the original Paso Robles-disturbed-Pasadena (PR-dist), Paso Robles- PasoLight (PR-PL), Arad-Samra, Arad-Hula, Tyrone- Berker Island1 and Tyrone-MountDarwin [2 ,3. ]Chemical characteristics indicate that the PR-dist and PR-PL soils could be derived from acid weathering of local Wishstone rocks while the Samra and Hula soils are likely derived from local Algonquin-Iroquet rock [3]. The Paso Robles soils were exposed to acidic sulfur bearing fluids; however, little else is known about the chemistry of the alteration fluid and its effects on the alteration of the proposed parent materials. The objectives of this work are to conduct titanium normalized mass-balance analysis to1) assess elemental gains and losses from the parent materials in the formation of the Paso Robles soils and 2) utilize this information to indicate the chemical nature of the alteration fluids.

  10. Effect of a high protein diet and/or resistance exercise on the preservation of fat free mass during weight loss in overweight and obese older adults : a randomized controlled trial

    NARCIS (Netherlands)

    Verreijen, Amely M; Engberink, Mariëlle F; Memelink, Robert G; van der Plas, Suzanne E; Visser, Marjolein; Weijs, Peter J M

    2017-01-01

    BACKGROUND: Intentional weight loss in obese older adults is a risk factor for accelerated muscle mass loss. We investigated whether a high protein diet and/or resistance exercise preserves fat free mass (FFM) during weight loss in overweight and obese older adults. METHODS: We included 100

  11. Long-lasting X-ray emission from type IIb supernova 2011dh and mass-loss history of the yellow supergiant progenitor

    Energy Technology Data Exchange (ETDEWEB)

    Maeda, Keiichi [Department of Astronomy, Kyoto University, Kitashirakawa-Oiwake-cho, Sakyo-ku, Kyoto 606-8502 (Japan); Katsuda, Satoru [RIKEN (The Institute of Physical and Chemical Research) Nishina Center, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Bamba, Aya [Department of Physics and Mathematics, Aoyama Gakuin University, 5-10-1 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5258 (Japan); Terada, Yukikatsu [Graduate School of Science and Engineering, Saitama University, Shimo-Okubo 255, Sakura, Saitama 338-8570 (Japan); Fukazawa, Yasushi, E-mail: keiichi.maeda@kusastro.kyoto-u.ac.jp [Department of Physical Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526 (Japan)

    2014-04-20

    Type IIb supernova (SN) 2011dh, with conclusive detection of an unprecedented yellow supergiant (YSG) progenitor, provides an excellent opportunity to deepen our understanding on the massive star evolution in the final centuries toward the SN explosion. In this paper, we report on detection and analyses of thermal X-ray emission from SN IIb 2011dh at ∼500 days after the explosion on Chandra archival data, providing a solidly derived mass-loss rate of a YSG progenitor for the first time. We find that the circumstellar media should be dense, more than that expected from a Wolf-Rayet (W-R) star by one order of magnitude. The emission is powered by a reverse shock penetrating into an outer envelope, fully consistent with the YSG progenitor but not with a W-R progenitor. The density distribution at the outermost ejecta is much steeper than that expected from a compact W-R star, and this finding must be taken into account in modeling the early UV/optical emission from SNe IIb. The derived mass-loss rate is ∼3 × 10{sup –6} M {sub ☉} yr{sup –1} for the mass-loss velocity of ∼20 km s{sup –1} in the final ∼1300 yr before the explosion. The derived mass-loss properties are largely consistent with the standard wind mass-loss expected for a giant star. This is not sufficient to be a main driver to expel nearly all the hydrogen envelope. Therefore, the binary interaction, with a huge mass transfer having taken place at ≳ 1300 yr before the explosion, is a likely scenario to produce the YSG progenitor.

  12. Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia) : the Longitudinal Aging Study Amsterdam

    NARCIS (Netherlands)

    Visser, Marjolein; Deeg, Dorly J H; Lips, Paul

    2003-01-01

    The age-related change in hormone concentrations has been hypothesized to play a role in the loss of muscle mass and muscle strength with aging, also called sarcopenia. The aim of this prospective study was to investigate whether low serum 25-hydroxyvitamin D (25-OHD) and high serum PTH

  13. Effects of high protein diets on fat-free mass and muscle protein synthesis following weight loss: a randomized controlled trial

    Science.gov (United States)

    Context: The benefits of high protein diets for sparing lean body mass and sustaining skeletal muscle protein metabolism during short-term weight loss in normal-weight adults are not well described. Objective: Determine the effects of varying levels of dietary protein intake on body compos...

  14. MASS LOSS AND NITROGEN DYNAMICS DURING THE DECOMPOSITION OF A N-LABELED N2-FIXING EPOPHYTIC LICHEN, LOBARIA OREGANA (TUCK.) MULL. ARG.

    Science.gov (United States)

    We studied mass loss and nitrogen dynamics during fall and spring initiated decomposition of an N2-fixing epiphytic lichen, Lobaria oregana (Tuck.) Mull. Arg. using 15N. We developed a method of labeling lichens with 15N that involved spraying lichen material with a nutrient sol...

  15. Mass loss and nutrient concentrations of buried wood as a function of organic matter removal, soil compaction, and vegetation control in a regenerating oak-pine forest

    Science.gov (United States)

    Felix Ponder; John M. Kabrick; Mary Beth Adams; Deborah S. Page-Dumroese; Marty F. Jurgensen

    2017-01-01

    Mass loss and nutrient concentrations of northern red oak (Quercus rubra) and white oak (Q. alba) wood stakes were measured 30 months after their burial in the upper 10 cm of soil in a regenerating forest after harvesting and soil disturbance. Disturbance treatments were two levels of organic matter (OM) removal (only...

  16. Change in fat-free mass assessed by bioelectrical impedance, total body potassium and dual energy X-ray absorptiometry during prolonged weight loss

    DEFF Research Database (Denmark)

    Hendel, H W; Gotfredsen, A; Højgaard, L

    1996-01-01

    A total of 16 obese women (body mass index (BMI) 30-43 kg m(-2)) participated in a weight reduction study. Before and after a weight loss of 11.7 +/- 7.4 kg (mean +/- SD), body composition was assessed by dual energy X-ray absorptiometry (DXA), and total body potassium counting (TBK). These measu...

  17. Chronologically scheduled snacking with high-protein products within the habitual diet in type-2 diabetes patients leads to a fat mass loss: a longitudinal study

    Directory of Open Access Journals (Sweden)

    Martínez J Alfredo

    2011-07-01

    Full Text Available Abstract Background Obesity is the most relevant overnutrition disease worldwide and is associated to different metabolic disorders such as insulin resistance and type-2 diabetes. Low glycemic load foods and diets and moderately high protein intake have been shown to reduce body weight and fat mass, exerting also beneficial effects on LDL-cholesterol, triglyceride concentrations, postprandial glucose curve and HDL-cholesterol levels. The present study aimed at studying the potential functionality of a series of low glycemic index products with moderately high protein content, as possible coadjuvants in the control of type-2 diabetes and weight management following a chronologically planned snacking offer (morning and afternoon. Methods The current trial followed a single group, sequential, longitudinal design, with two consecutive periods of 4 weeks each. A total of 17 volunteers participated in the study. The first period was a free living period, with volunteers' habitual ad libitum dietary pattern, while the second period was a free-living period with structured meal replacements at breakfast, morning snack and afternoon snack, which were exchanged by specific products with moderately high protein content and controlled low glycemic index, following a scheduled temporal consumption. Blood extractions were performed at the beginning and at the end of each period (free-living and intervention. Parameters analysed were: fasting glucose, insulin, glycosylated hemoglobin, total-, HDL- and LDL-cholesterol, triglyceride, C - reactive protein and Homocysteine concentrations. Postprandial glucose and insulin were also measured. Anthropometrical parameters were monitored each 2 weeks during the whole study. Results A modest but significant (p = 0.002 reduction on body weight (1 kg was observed during the intervention period, mainly due to the fat mass loss (0.8 kg, p = 0.02. This weight reduction was observed without apparently associated changes in

  18. Establishment of age- and sex-adjusted reference data for hand bone mass and investigation of hand bone loss in patients with rheumatoid arthritis treated in clinical practice

    DEFF Research Database (Denmark)

    Ørnbjerg, Lykke Midtbøll; Østergaard, Mikkel; Jensen, Trine

    2016-01-01

    remission (0.0032 vs. 0.0058 g/cm(2)/year; p clinical practice, and only......BACKGROUND: Rheumatoid arthritis is characterised by progressive joint destruction and loss of periarticular bone mass. Hand bone loss (HBL) has therefore been proposed as an outcome measure for treatment efficacy. A definition of increased HBL adjusted for age- and sex-related bone loss is lacking....... In this study, we aimed to: 1) establish reference values for normal hand bone mass (bone mineral density measured by digital x-ray radiogrammetry (DXR-BMD)); and 2) examine whether HBL is normalised in rheumatoid arthritis patients during treatment with tumour necrosis factor alpha inhibitors (TNFI). METHODS...

  19. Compensating effect of minor portal hypertension on the muscle mass loss-related poor prognosis in cirrhosis.

    Science.gov (United States)

    Maruyama, Hitoshi; Kobayashi, Kazufumi; Kiyono, Soichiro; Ogasawara, Sadahisa; Suzuki, Eichiro; Ooka, Yoshihiko; Chiba, Tetsuhiro; Yamaguchi, Tadashi

    2017-01-01

    Background: To examine the influence of the severity of portal hemodynamic abnormality on the prognosis of cirrhosis with respect to the muscle mass loss (MML). Methods: The study involved a subgroup analysis in 98 cirrhosis patients (63.5 ± 11.8 years) who prospectively underwent both Doppler ultrasound and hepatic venous catheterization. The prognostic influence of MML diagnosed by computed tomography using the L3 skeletal muscle index was evaluated (median observation period, 32.7 months). Results: The cumulative survival rate showed difference between patients with MML (n = 34; 82.2%/1year, 41.2%/3years and 36.1%/5years) and those without (n = 64; 92.1%/1year, 74.9%/3years and 69.4%/5years; P = 0.005). When divided with respect to the portal velocity, the survival rate showed differences between patients with and without MML in the cohort 12 mmHg. However, in the cohort with HVPG ≤ 12 mmHg, survival rate showed no difference between patients with MML (n=10; 100%/1year, 61.9%/3years and 61.9%/5years) and those without (n=19; 93.8%/1year, 71.2%/3years and 59.4%/5years; p = 0.493) Conclusion: Lower HVPG has a compensating effect on the MML-induced poor prognosis of cirrhosis. Care should be taken in the evaluation of the influence of MML in consideration of the severity of portal hypertension.

  20. Vapour pressures of selected organic compounds down to 1 mPa, using mass-loss Knudsen effusion method

    International Nuclear Information System (INIS)

    Fonseca, José M.S.; Gushterov, Nikola; Dohrn, Ralf

    2014-01-01

    Graphical abstract: - Highlights: • A recently described mass-loss Knudsen apparatus was used for measurements of vapour pressures down to around 1 mPa. • Complementary calorimetric studies were performed in a Calvet-type calorimeter. • New vapour pressures are given for benzoic acid and benzanthrone, in ranges in which no consistent data existed. • Vapour pressures for solid n-octadecane are presented, correcting existing values from literature. - Abstract: A recently developed Knudsen effusion apparatus was improved and used for measurements of vapour pressures of selected organic compounds. Calorimetric studies were conducted using a Calvet-type calorimeter, complementing the information obtained for the vapour pressures and facilitating the modelling and analysis of the data. Vapour pressures of benzoic acid, a reference substance, were determined at temperatures between 269 K and 317 K, corresponding to a pressure range from 2 mPa to 1 Pa, extending the range of results available in the literature to lower pressures. Benzanthrone was studied between temperatures 360 K and 410 K (5 mPa–1 Pa) in order to test the apparatus at higher temperatures. Values presented in the literature for the vapour pressure of solid n-octadecane, one of the most promising compounds to be used as “phase change material” for textile applications, were found inconsistent with the triple point of the substance. Sublimation pressures were measured for this compound between T = 286 K and 298 K (2–20 mPa) allowing the correction of the existing values. Finally, vapour pressures of diphenyl carbonate, a compound of high industrial relevance for its use in the production of polycarbonates, were determined from T = 302 K to 332 K (0.02–1 Pa)

  1. Photometric and polarimetric variability and mass-loss rate of the massive binary Wolf-Rayet star HDE 311884 (WN6 + 05: V)

    International Nuclear Information System (INIS)

    Moffat, A.F.J.; Drissen, L.; Robert, C.; Lamontagne, R.; Coziol, R.

    1990-01-01

    Photometric and polarimetric monitoring of the Wolf-Rayet (W-R) + O-type binary system HDE 311884 = WR 47 over many orbital cycles shows the clear effects of phase-dependent electron scattering of O-star light as the orbiting O companion shines through varying column density of W-R stellar wind material. In contrast to this wind-type eclipse, the stars themselves do not quite eclipse. Both photometry and polarimetry give a consistent estimate of the mass-loss rate of the W-R component: at about 0.00003 solar mass/yr. The orbital inclination, i = 70 deg, along with the previously published velocity orbit, yields high masses: M(WN6) = 48 solar masses and M(O5:V) = 57 solar masses. 33 refs

  2. Interdependence of physical inactivity, loss of muscle mass and low dietary intake: Extrapulmonary manifestations in older chronic obstructive pulmonary disease patients.

    Science.gov (United States)

    Yoshimura, Kazuya; Sato, Susumu; Muro, Shigeo; Yamada, Minoru; Hasegawa, Koichi; Kiyokawa, Hirofumi; Mishima, Michiaki; Aoyama, Tomoki

    2018-01-01

    Extrapulmonary manifestations, such as reductions in skeletal muscle and physical inactivity, are important clinical features of patients with chronic obstructive pulmonary disease (COPD), and might depend on the severity of COPD. As it is still unclear whether the relationship between muscle loss and physical inactivity is dominated by a disease-specific relationship or caused by patient factors, including physiological aging, we aimed to investigate the pulmonary or extrapulmonary factors associated with physical inactivity among older COPD patients. A total of 38 older male COPD patients (aged ≥65 years) were enrolled, and were evaluated cross-sectionally. Skeletal muscle mass was measured using bioelectrical impedance, and physical activity and energy intake were recorded for 2 weeks using a pedometer and diary. Daily step counts were successfully evaluated in 28 participants (mean forced expiratory volume in 1 s [%predicted; %FEV 1 ]; 49.5%), and ranged widely. The mean step counts was 5166 steps/day, and found to have a significant relationship with dyspnea (r = -0.46), diffusing capacity (r = 0.47), %FEV1 (r = 0.44), skeletal muscle index (r = 0.59) and total dietary intake (r = 0.47), but not with age (P = 0.14). A stepwise multivariate analysis showed that the skeletal muscle index (β = 0.50) and total dietary intake (β = 0.35) were significant determinants of the daily step count (R 2 = 0.46, p physical activity, skeletal muscle mass and dietary intake are more closely correlated with physical activity in COPD patients. Because physical inactivity might be the strongest predictor of prognosis, the present results suggest that a comprehensive treatment strategy must be considered for older COPD patients to improve their extrapulmonary manifestations and pulmonary dysfunction. Geriatr Gerontol Int 2018; 18: 88-94. © 2017 Japan Geriatrics Society.

  3. The significance of a hypoplastic bony canal for the cochlear nerve in patients with sensorineural hearing loss: CT and MRI findings

    International Nuclear Information System (INIS)

    Choi, Yoon Jung; Park, Sang Yoo; Kim, Myung Soon; Sung, Ki Jun

    2004-01-01

    The purpose of this study is to evaluate the significance of the hypoplastic canal for the cochlear nerve in patients with sensorineural hearing loss (SNHL) and the relationship between the hypoplastic bony canal and aplasia or hypoplasia of the cochlear nerve. A retrospective review of high resolution temporal CT(HRCT) and MRI findings was conducted. The narrow bony canal of the cochlear nerve and the relative size of the internal auditory canal were correlated with the cochlear nerve deficiency on MRI. The comparative size of the component nerves (facial, cochlear, superior vestibular, inferior vestibular nerve), and the relative size of the internal auditory canal and the bony canal of the cochlear nerve were measured. The clinical history and the results of the clinical examination were reviewed for each patient. High resolution MRI showed aplasia of the common vestibulocochlear nerve in one patient and a deficiency of the cochlear nerve in 9 patients. These abnormalities occurred in association with a prominent narrowing of the canal for the cochlear nerve and a stenosis of the internal auditory canal, which was observed on temporal bone CT in 9 patients with congenital SNHL. Three patients had normal IAC, despite the presence of a hypoplastic cochlear nerve on the side on which they had SNHL. In one patient, the narrowing of the canal for the cochlear nerve and internal auditory canal were not found to be associated with acquired SNHL. The hypoplastic bony canal for the cochlear nerve might be more highly indicative of congenital cochlear nerve deficiency than that of the narrow internal auditory canal, and the position of the crista falciformis should also be carefully

  4. The significance of a hypoplastic bony canal for the cochlear nerve in patients with sensorineural hearing loss: CT and MRI findings

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Yoon Jung; Park, Sang Yoo; Kim, Myung Soon; Sung, Ki Jun [College of Medicine, Yonsei Univ., Wonju (Korea, Republic of)

    2004-04-01

    The purpose of this study is to evaluate the significance of the hypoplastic canal for the cochlear nerve in patients with sensorineural hearing loss (SNHL) and the relationship between the hypoplastic bony canal and aplasia or hypoplasia of the cochlear nerve. A retrospective review of high resolution temporal CT(HRCT) and MRI findings was conducted. The narrow bony canal of the cochlear nerve and the relative size of the internal auditory canal were correlated with the cochlear nerve deficiency on MRI. The comparative size of the component nerves (facial, cochlear, superior vestibular, inferior vestibular nerve), and the relative size of the internal auditory canal and the bony canal of the cochlear nerve were measured. The clinical history and the results of the clinical examination were reviewed for each patient. High resolution MRI showed aplasia of the common vestibulocochlear nerve in one patient and a deficiency of the cochlear nerve in 9 patients. These abnormalities occurred in association with a prominent narrowing of the canal for the cochlear nerve and a stenosis of the internal auditory canal, which was observed on temporal bone CT in 9 patients with congenital SNHL. Three patients had normal IAC, despite the presence of a hypoplastic cochlear nerve on the side on which they had SNHL. In one patient, the narrowing of the canal for the cochlear nerve and internal auditory canal were not found to be associated with acquired SNHL. The hypoplastic bony canal for the cochlear nerve might be more highly indicative of congenital cochlear nerve deficiency than that of the narrow internal auditory canal, and the position of the crista falciformis should also be carefully.

  5. Clinical and biological significance of isolated Y chromosome loss in myelodysplastic syndromes and chronic myelomonocytic leukemia. A report from the Spanish MDS Group.

    Science.gov (United States)

    Nomdedeu, Meritxell; Pereira, Arturo; Calvo, Xavier; Colomer, Joan; Sole, Francesc; Arias, Amparo; Gomez, Candida; Luño, Elisa; Cervera, Jose; Arnan, Montserrat; Pomares, Helena; Ramos, Fernando; Oiartzabal, Itziar; Espinet, Blanca; Pedro, Carme; Arrizabalaga, Beatriz; Blanco, María Laura; Tormo, Mar; Hernandez-Rivas, Jesus Maria; Díez-Campelo, María; Ortega, Margarita; Valcárcel, David; Cedena, Maria-Teresa; Collado, Rosa; Grau, Javier; Granada, Isabel; Sanz, Guillermo; Campo, Elias; Esteve, Jordi; Costa, Dolors

    2017-12-01

    Isolate loss of chromosome Y (-Y) in myelodysplastic syndromes (MDS) is associated to a better outcome but it is also well described as an age-related phenomenon. In this study we aimed to analyze the prognostic impact of -Y in the context of the IPSS-R cytogenetic classification, evaluate the clinical significance of the percentage of metaphases with isolated -Y, and test whether finding -Y may predispose to over-diagnose MDS in patients with borderline morphological features. We evaluated 3581 male patients from the Spanish MDS Registry with a diagnosis of MDS or chronic myelomonocytic leukemia (CMML). -Y was identified in 177 patients (4.9%). Compared with the 2246 male patients with normal karyotype, -Y group showed a reduced risk of leukemic transformation that did not translate into a survival advantage. The overall survival and the risk of leukemic transformation were not influenced by the percentage of metaphases with -Y. The -Y group was not enriched in patients with minor morphologic traits of dysplasia, suggesting that the better outcome in the -Y group cannot be explained by enrichment in cases misdiagnosed as MDS. In conclusion, our results support the current recommendation of classifying patients with -Y within the very good risk category of the IPSS-R for MDS and rule out a selection bias as a possible explanation of this better outcome. An analysis of the molecular basis of MDS with isolated -Y would be of interest as it may provide a biological basis of protection against progression to acute leukemia. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Change in fat-free mass assessed by bioelectrical impedance, total body potassium and dual energy X-ray absorptiometry during prolonged weight loss

    DEFF Research Database (Denmark)

    Hendel, H W; Gotfredsen, A; Højgaard, L

    1996-01-01

    A total of 16 obese women (body mass index (BMI) 30-43 kg m(-2)) participated in a weight reduction study. Before and after a weight loss of 11.7 +/- 7.4 kg (mean +/- SD), body composition was assessed by dual energy X-ray absorptiometry (DXA), and total body potassium counting (TBK). These measu......A total of 16 obese women (body mass index (BMI) 30-43 kg m(-2)) participated in a weight reduction study. Before and after a weight loss of 11.7 +/- 7.4 kg (mean +/- SD), body composition was assessed by dual energy X-ray absorptiometry (DXA), and total body potassium counting (TBK......). These measurements were compared with bioimpedance analysis (BIA) by applying 11 predictive BIA equations published in the literature. Predictive equations for the present study population were developed, with the use of fat-free mass (FFM) as assessed by TBK and DXA as references in multiple regression analysis....... The results of the BIA equations varied widely; FFM was generally overestimated by BIA as compared with DXA and TBK before and after weight loss. During weight loss, the FFM did not change, as estimated by DXA (1.3 +/- 2.3 kg, p > 0.05) and TBK (0.9 +/- 2.9 kg, p > 0.05). The recorded change in impedance (R...

  7. Combining Fragment-Ion and Neutral-Loss Matching during Mass Spectral Library Searching: A New General Purpose Algorithm Applicable to Illicit Drug Identification.

    Science.gov (United States)

    Moorthy, Arun S; Wallace, William E; Kearsley, Anthony J; Tchekhovskoi, Dmitrii V; Stein, Stephen E

    2017-12-19

    A mass spectral library search algorithm that identifies compounds that differ from library compounds by a single "inert" structural component is described. This algorithm, the Hybrid Similarity Search, generates a similarity score based on matching both fragment ions and neutral losses. It employs the parameter DeltaMass, defined as the mass difference between query and library compounds, to shift neutral loss peaks in the library spectrum to match corresponding neutral loss peaks in the query spectrum. When the spectra being compared differ by a single structural feature, these matching neutral loss peaks should contain that structural feature. This method extends the scope of the library to include spectra of "nearest-neighbor" compounds that differ from library compounds by a single chemical moiety. Additionally, determination of the structural origin of the shifted peaks can aid in the determination of the chemical structure and fragmentation mechanism of the query compound. A variety of examples are presented, including the identification of designer drugs and chemical derivatives not present in the library.

  8. A Study of Hypergiant Mass Loss in the Near-To-Mid Infrared: VY CMa, IRC +10420, mu Cep and rho Cas

    Science.gov (United States)

    Shenoy, Dinesh Prabhakar

    2016-01-01

    Stars of initial mass greater than 9 M_sun become red supergiants (RSGs), a short-lived stage during which they experience mass-loss that strongly influences their post-RSG evolution and end state. The highest luminosity RSGs, referred to here as hypergiants, experience episodic mass-loss whose mechanism remains poorly understood and motivates observations to help constrain it. This thesis studies mass loss from hypergiant stars with near-to-mid infrared imaging over a range of angular scales. The recent mass-loss history of the extreme red supergiant VY Canis Majoris and the warm hypergiant star IRC +10420 are studied at the sub-arcsecond scale with adaptive optics imaging and imaging polarimetry from 1 - 5 micron using LMIRCam on the Large Binocular Telescope (LBT) and MMT-Pol at the MMT Observatory. The nebular features of VY CMa are found to be highly polarized at 1.3 and 3.1 micron, with optically thick scattering required to reproduce the observed surface brightness. The flux of VY CMa's peculiar ``Southwest Clump'' is demonstrated to be due almost entirely to optically thick scattering, with little thermal emission, and with a lower limit mass of 5E-03 M_sun in this single feature. The imaging polarimetry of IRC +10420 at 2.2 micron resolves nebular emission with intrinsic polarization of 30%, with a high surface brightness indicating optically thick scattering largely in the plane of the sky. Using the polarimetry to constrain the scattered light emission, it is shown that the nebula's the emission is mostly thermal with a color temperature well above that for typical astrophysical dust. To probe further into hypergiants' history of mass-loss, mid-IR imaging with MMT/ MIRAC and SOFIA/FORCAST is used to study VY CMa, IRC +10420 and two additional hypergiants: the RSG mu Cep and the warm hypergiant rho Cas. Using DUSTY 1-D radiative transfer models, mu Cep's mass-loss rate is found to have declined by about a factor of 5 over a 13,000 history, ranging from 5E

  9. Redox Evolution via Gravitational Differentiation on Low-mass Planets: Implications for Abiotic Oxygen, Water Loss, and Habitability

    Science.gov (United States)

    Wordsworth, R. D.; Schaefer, L. K.; Fischer, R. A.

    2018-05-01

    The oxidation of rocky planet surfaces and atmospheres, which arises from the twin forces of stellar nucleosynthesis and gravitational differentiation, is a universal process of key importance to habitability and exoplanet biosignature detection. Here we take a generalized approach to this phenomenon. Using a single parameter to describe the redox state, we model the evolution of terrestrial planets around nearby M stars and the Sun. Our model includes atmospheric photochemistry, diffusion and escape, line-by-line climate calculations, and interior thermodynamics and chemistry. In most cases, we find abiotic atmospheric {{{O}}}2 buildup around M stars during the pre-main-sequence phase to be much less than calculated previously, because the planet’s magma ocean absorbs most oxygen liberated from {{{H}}}2{{O}} photolysis. However, loss of noncondensing atmospheric gases after the mantle solidifies remains a significant potential route to abiotic atmospheric {{{O}}}2 subsequently. In all cases, we predict that exoplanets that receive lower stellar fluxes, such as LHS1140b and TRAPPIST-1f and g, have the lowest probability of abiotic {{{O}}}2 buildup and hence may be the most interesting targets for future searches for biogenic {{{O}}}2. Key remaining uncertainties can be minimized in future by comparing our predictions for the atmospheres of hot, sterile exoplanets such as GJ1132b and TRAPPIST-1b and c with observations.

  10. Moderate Walking Enhances the Effects of an Energy-Restricted Diet on Fat Mass Loss and Serum Insulin in Overweight and Obese Adults in a 12-Week Randomized Controlled Trial.

    Science.gov (United States)

    Kleist, Bernadette; Wahrburg, Ursel; Stehle, Peter; Schomaker, Ralph; Greiwing, Andreas; Stoffel-Wagner, Birgit; Egert, Sarah

    2017-08-09

    Background: Increased physical activity may be advantageous for weight loss. Objective: We investigated the effects of an energy-restricted diet with and without moderate walking on body weight, body composition, resting energy expenditure (REE), and endocrine and cardiometabolic risk variables in overweight and obese participants. Methods: A 12-wk, randomized, 2-arm, parallel, controlled, energy-restricted (500-800 kcal/d) dietary intervention study was conducted in 82 men and women [mean baseline characteristics: age, 39.4 y; weight, 99.3 kg; body mass index (in kg/m 2 ), 31.9]. Participants were divided into 2 groups. One group received a hypoenergetic diet (DI) only ( n = 44). The second group received the same DI and participated in a regular walking program of 2.5 h/wk (DI + walking; n = 38). Results: After the 12-wk intervention, body weight was significantly decreased in the DI + walking group and the DI group (-8.8 compared with -7.0 kg, P = 0.064 for intergroup differences). The decrease in body weight was accompanied by a significant reduction in total fat mass, which was significantly more pronounced in the DI + walking group than in the DI group (-6.4 ± 3.1 compared with -4.8 ± 3.0 kg; P = 0.020). REE after 12 wk was not significantly different compared with the baseline REE. Diastolic blood pressure, mean arterial pressure, LDL cholesterol, and non-HDL cholesterol were similarly significantly improved by both interventions. In the DI + walking group, insulin and the homeostasis model assessment of insulin resistance index were also significantly reduced. Serum free triiodothyronine was significantly decreased and serum cortisol was significantly increased in both groups. Conclusions: Participation in a 12-wk weight-loss study resulted in significant reductions in body weight and fat mass and was associated with significant improvements in biomarkers for cardiovascular disease risk. Moderate weight loss was not accompanied by a reduction in REE

  11. Effect of a high protein diet and/or resistance exercise on the preservation of fat free mass during weight loss in overweight and obese older adults: a randomized controlled trial.

    Science.gov (United States)

    Verreijen, Amely M; Engberink, Mariëlle F; Memelink, Robert G; van der Plas, Suzanne E; Visser, Marjolein; Weijs, Peter J M

    2017-02-06

    Intentional weight loss in obese older adults is a risk factor for accelerated muscle mass loss. We investigated whether a high protein diet and/or resistance exercise preserves fat free mass (FFM) during weight loss in overweight and obese older adults. We included 100 overweight and obese adults (55-80 year) in a randomized controlled trial (RCT) with a 2 × 2 factorial design and intention-to-treat analysis. During a 10-week weight loss program all subjects followed a hypocaloric diet. Subjects were randomly allocated to either a high protein (1.3 g/kg body weight) or normal protein diet (0.8 g/kg), with or without a resistance exercise program 3 times/week. FFM was assessed by air displacement plethysmography. At baseline, mean (±SD) BMI was 32 ± 4 kg/m 2 . During intervention, protein intake was 1.13 ± 0.35 g/kg in the high protein groups vs. 0.98 ± 0.29 in the normal protein groups, which reflects a 16.3 ± 5.2 g/d higher protein intake in the high protein groups. Both high protein diet and exercise did not significantly affect change in body weight, FFM and fat mass (FM). No significant protein*exercise interaction effect was observed for FFM. However, within-group analysis showed that high protein in combination with exercise significantly increased FFM (+0.6 ± 1.3 kg, p = 0.011). A high protein diet, though lower than targeted, did not significantly affect changes in FFM during modest weight loss in older overweight and obese adults. There was no significant interaction between the high protein diet and resistance exercise for change in FFM. However, only the group with the combined intervention of high protein diet and resistance exercise significantly increased in FFM. Dutch Trial Register, number NTR4556, date 05-01-2014.

  12. A high whey protein-, leucine-, and vitamin D-enriched supplement preserves muscle mass during intentional weight loss in obese older adults: a double-blind randomized controlled trial

    NARCIS (Netherlands)

    Verreijen, A.M.; Verlaan, S.; Engberink, M.F.; Swinkels, S.; Bosch, J.; Weijs, P.J.M.

    2015-01-01

    Background: Intentional weight loss in obese older adults is a risk factor for muscle loss and sarcopenia. Objective: The objective was to examine the effect of a high whey protein-, leucine-, and vitamin D-enriched supplement on muscle mass preservation during intentional weight loss in obese older

  13. A soluble activin type IIA receptor mitigates the loss of femoral neck bone strength and cancellous bone mass in a mouse model of disuse osteopenia.

    Science.gov (United States)

    Lodberg, Andreas; Eijken, Marco; van der Eerden, Bram C J; Okkels, Mette Wendelboe; Thomsen, Jesper Skovhus; Brüel, Annemarie

    2018-05-01

    Disuse causes a rapid and substantial bone loss distinct in its pathophysiology from the bone loss associated with cancers, age, and menopause. While inhibitors of the activin-receptor signaling pathway (IASPs) have been shown to prevent ovariectomy- and cancer-induced bone loss, their application in a model of disuse osteopenia remains to be tested. Here, we show that a soluble activin type IIA receptor (ActRIIA-mFc) increases diaphyseal bone strength and cancellous bone mass, and mitigates the loss of femoral neck bone strength in the Botulinum Toxin A (BTX)-model of disuse osteopenia in female C57BL/6J mice. We show that ActRIIA-mFc treatment preferentially stimulates a dual-effect (anabolic-antiresorptive) on the periosteal envelope of diaphyseal bone, demonstrating in detail the effects of ActRIIA-mFc on cortical bone. These observations constitute a previously undescribed feature of IASPs that mediates at least part of their ability to mitigate detrimental effects of unloading on bone tissue. The study findings support the application of IASPs as a strategy to combat bone loss during disuse. Copyright © 2018 Elsevier Inc. All rights reserved.

  14. THE MASS LOSS RETURN FROM EVOLVED STARS TO THE LARGE MAGELLANIC CLOUD: EMPIRICAL RELATIONS FOR EXCESS EMISSION AT 8 AND 24 μm

    International Nuclear Information System (INIS)

    Srinivasan, Sundar; Meixner, Margaret; Leitherer, Claus; Vijh, Uma; Gordon, Karl D.; Sewilo, Marta; Volk, Kevin; Blum, Robert D.; Harris, Jason; Babler, Brian L.; Bracker, Steve; Meade, Marilyn; Block, Miwa; Engelbracht, Charles W.; For, Bi-Qing; Misselt, Karl A.; Cohen, Martin; Hora, Joseph L.; Indebetouw, Remy; Markwick-Kemper, Francisca

    2009-01-01

    We present empirical relations describing excess emission from evolved stars in the Large Magellanic Cloud (LMC) using data from the Spitzer Space Telescope Surveying the Agents of a Galaxy's Evolution (SAGE) survey which includes the Infrared Array Camera (IRAC) 3.6, 4.5, 5.8, and 8.0 μm and Multiband Imaging Photometer (MIPS) 24, 70, and 160 μm bands. We combine the SAGE data with the Two Micron All Sky Survey (2MASS; J, H, and K s ) and the optical Magellanic Cloud Photometric Survey (MCPS; U, B, V, and I) point source catalogs in order to create complete spectral energy distributions (SEDs) of the asymptotic giant branch (AGB) star candidates in the LMC. AGB star outflows are among the main producers of dust in a galaxy, and this mass loss results in an excess in the fluxes observed in the 8 and 24 μm bands. The aim of this work is to investigate the mass loss return by AGB stars to the interstellar medium of the LMC by studying the dependence of the infrared excess flux on the total luminosity. We identify oxygen-rich, carbon-rich, and extreme AGB star populations in our sample based on their 2MASS and IRAC colors. The SEDs of oxygen- and carbon-rich AGB stars are compared with appropriate stellar photosphere models to obtain the excess flux in all the IRAC bands and the MIPS 24 μm band. Extreme AGB stars are dominated by circumstellar emission at 8 and 24 μm; thus we approximate their excesses with the flux observed in these bands. We find about 16,000 O-rich, 6300 C-rich, and 1000 extreme sources with reliable 8 μm excesses, and about 4500 O-rich, 5300 C-rich, and 960 extreme sources with reliable 24 μm excesses. The excesses are in the range 0.1 mJy to 5 Jy. The 8 and 24 μm excesses for all three types of AGB candidates show a general increasing trend with luminosity. The color temperature of the circumstellar dust derived from the ratio of the 8 and 24 μm excesses decreases with an increase in excess, while the 24 μm optical depth increases with

  15. Formulation and evaluation of the use of edible coatings based on gellan chunks of fresh pineapple cut to minimize deterioration of quality attributes and mass loss

    International Nuclear Information System (INIS)

    Saborio Marin, Laura

    2014-01-01

    The result of the use of edible coatings on special based of gellan in various formulations applied on pieces of fresh cut pineapple is evaluated to reduce the degradation of the quality characteristics and mass loss, as a plan to increase the usefulness. The effect of storage time of the fruit before processing (TAP), the application of vacuum pressure and concentration has been studied of the active components (gellan (0,50-1,00%), oil (0,00 -0,20%), glycerol and sorbitol (1,5-2,5%), CaCl 2 (1.0-10,0%)) of the forming solutions of coating. Several parameters are evaluated: the loss of juice, weight and composition of O 2 and CO 2 in the headspace, content of soluble solids (SS), titratable acidity (TA) color, darkening and appearance of pineapple chunks. The effect of forming solutions is measured on the adhesion, uniformity, coverage and determination of the water vapor resistance (RVA) coating and the presence of molds and yeasts during refrigerated storage at 5 degrees Celsius and 80% relative humidity. Another finding was that the loss of juice of the pieces uncoated increased (p≤0,05) as the increase TAP of 1 to 3 weeks, still higher than those of the coated pieces (0,50-0,75% gellan ), which have been minimal, while weight loss has decreased. The application of a vacuum pressure of 0,08 MPa before coating the pieces has favored the juice loss after the first two weeks of storage and reduced weight loss of uncoated pieces along the storage. The formulation comprised of 0,75% gellan, 1,5% glycerol, 0,10% oil and 1,0% of CaCl 2 has been which allows further reduction of juice loss and weight of pineapple chunks stored at 5 degrees Celsius and 80% RH [es

  16. Factors which modulate the rates of skeletal muscle mass loss in non-small cell lung cancer patients: a pilot study.

    Science.gov (United States)

    Atlan, Philippe; Bayar, Mohamed Amine; Lanoy, Emilie; Besse, Benjamin; Planchard, David; Ramon, Jordy; Raynard, Bruno; Antoun, Sami

    2017-11-01

    Advanced non-small cell lung cancer (NSCLC) is associated with weight loss which may reflect skeletal muscle mass (SMM) and/or total adipose tissue (TAT) depletion. This study aimed to describe changes in body composition (BC) parameters and to identify the factors unrelated to the tumor which modulate them. SMM, TAT, and the proportion of SMM to SMM + TAT were assessed with computed tomography. Estimates of each BC parameter at follow-up initiation and across time were derived from a mixed linear model of repeated measurements with a random intercept and a random slope. The same models were used to assess the independent effect of gender, age, body mass index (BMI), and initial values on changes in each BC parameter. Sixty-four patients with stage III or IV NSCLC were reviewed. The mean ± SD decreases in body weight and SMM were respectively 59 ± 3 g/week (P SMM to SMM + TAT, estimated at 37 ± 2% at baseline. SMM loss was influenced by initial BMI (P SMM values (P = 0.0002): the higher the initial BMI or SMM values, the greater the loss observed. Weight loss was greater when the initial weight was heavier (P SMM wasting in NSCLC is lower when initial SMM and BMI values are low. These exploratory findings after our attempt to better understand the intrinsic factors associated with muscle mass depletion need to be confirmed in larger studies.

  17. Quality change and mass loss of paddy during airtight storage in a ferro-cement bin in Sri Lanka

    NARCIS (Netherlands)

    Adhikarinayake, T.B.; Palipane, K.B.; Müller, J.

    2006-01-01

    In Sri Lanka, prices for paddy fluctuate severely showing a minimum price at harvest. To benefit from higher prices, farmers strive to store paddy, but lack of facilities and poor storage management cause quantitative and qualitative losses by rodents, insects and microbial deterioration. To

  18. Contribution of Soil Fauna to Foliar Litter-Mass Loss in Winter in an Ecotone between Dry Valley and Montane Forest in the Upper Reaches of the Minjiang River.

    Science.gov (United States)

    Peng, Yan; Yang, Wanqin; Li, Jun; Wang, Bin; Zhang, Chuan; Yue, Kai; Wu, Fuzhong

    2015-01-01

    Litter decomposition during winter can provide essential nutrients for plant growth in the subsequent growing season, which plays important role in preventing the expansion of dry areas and maintaining the stability of ecotone ecosystems. However, limited information is currently available on the contributions of soil fauna to litter decomposition during winter in such ecosystems. Therefore, a field experiment that included litterbags with two different mesh sizes (0.04 mm and 3 mm) was conducted to investigate the contribution of soil fauna to the loss of foliar litter mass in winter from November 2013 to April 2014 along the upper reaches of the Minjiang River. Two litter types of the dominant species were selected in each ecosystem: cypress (Cupressus chengiana) and oak (Quercus baronii) in ecotone; cypress (Cupressus chengiana) and clovershrub (Campylotropis macrocarpa) in dry valley; and fir (Abies faxoniana) and birch (Betula albosinensis) in montane forest. Over one winter incubation, foliar litter lost 6.0%-16.1%, 11.4%-26.0%, and 6.4%-8.5% of initial mass in the ecotone, dry valley and montane forest, respectively. Soil fauna showed obvious contributions to the loss of foliar litter mass in all of the ecosystems. The highest contribution (48.5%-56.8%) was observed in the ecotone, and the lowest contribution (0.4%-25.8%) was observed in the montane forest. Compared with other winter periods, thawing period exhibited higher soil fauna contributions to litter mass loss in ecotone and dry valley, but both thawing period and freezing period displayed higher soil fauna contributions in montane forest. Statistical analysis demonstrated that the contribution of soil fauna was significantly correlated with temperature and soil moisture during the winter-long incubation. These results suggest that temperature might be the primary control factor in foliar litter decomposition, but more active soil fauna in the ecotone could contribute more in litter decomposition and

  19. Contribution of Soil Fauna to Foliar Litter-Mass Loss in Winter in an Ecotone between Dry Valley and Montane Forest in the Upper Reaches of the Minjiang River.

    Directory of Open Access Journals (Sweden)

    Yan Peng

    Full Text Available Litter decomposition during winter can provide essential nutrients for plant growth in the subsequent growing season, which plays important role in preventing the expansion of dry areas and maintaining the stability of ecotone ecosystems. However, limited information is currently available on the contributions of soil fauna to litter decomposition during winter in such ecosystems. Therefore, a field experiment that included litterbags with two different mesh sizes (0.04 mm and 3 mm was conducted to investigate the contribution of soil fauna to the loss of foliar litter mass in winter from November 2013 to April 2014 along the upper reaches of the Minjiang River. Two litter types of the dominant species were selected in each ecosystem: cypress (Cupressus chengiana and oak (Quercus baronii in ecotone; cypress (Cupressus chengiana and clovershrub (Campylotropis macrocarpa in dry valley; and fir (Abies faxoniana and birch (Betula albosinensis in montane forest. Over one winter incubation, foliar litter lost 6.0%-16.1%, 11.4%-26.0%, and 6.4%-8.5% of initial mass in the ecotone, dry valley and montane forest, respectively. Soil fauna showed obvious contributions to the loss of foliar litter mass in all of the ecosystems. The highest contribution (48.5%-56.8% was observed in the ecotone, and the lowest contribution (0.4%-25.8% was observed in the montane forest. Compared with other winter periods, thawing period exhibited higher soil fauna contributions to litter mass loss in ecotone and dry valley, but both thawing period and freezing period displayed higher soil fauna contributions in montane forest. Statistical analysis demonstrated that the contribution of soil fauna was significantly correlated with temperature and soil moisture during the winter-long incubation. These results suggest that temperature might be the primary control factor in foliar litter decomposition, but more active soil fauna in the ecotone could contribute more in litter

  20. Effects of 4 weight-loss diets differing in fat, protein, and carbohydrate on fat mass, lean mass, visceral adipose tissue, and hepatic fat: results from the POUNDS LOST trial123

    Science.gov (United States)

    de Souza, Russell J; Carey, Vincent J; Hall, Kevin D; LeBoff, Meryl S; Loria, Catherine M; Laranjo, Nancy M; Sacks, Frank M; Smith, Steven R

    2012-01-01

    Background: Weight loss reduces body fat and lean mass, but whether these changes are influenced by macronutrient composition of the diet is unclear. Objective: We determined whether energy-reduced diets that emphasize fat, protein, or carbohydrate differentially reduce total, visceral, or hepatic fat or preserve lean mass. Design: In a subset of participants in a randomized trial of 4 weight-loss diets, body fat and lean mass (n = 424; by using dual-energy X-ray absorptiometry) and abdominal and hepatic fat (n = 165; by using computed tomography) were measured after 6 mo and 2 y. Changes from baseline were compared between assigned amounts of protein (25% compared with 15%) and fat (40% compared with 20%) and across 4 carbohydrate amounts (35% through 65%). Results: At 6 mo, participants lost a mean (±SEM) of 4.2 ± 0.3 kg (12.4%) fat and 2.1 ± 0.3 kg (3.5%) lean mass (both P fat (P ≥ 0.34), or 65% and 35% carbohydrate (P ≥ 0.27). Participants lost 2.3 ± 0.2 kg (13.8%) abdominal fat: 1.5 ± 0.2 kg (13.6%) subcutaneous fat and 0.9 ± 0.1 kg (16.1%) visceral fat (all P fat than did men relative to total-body fat loss. Participants regained ∼40% of these losses by 2 y, with no differences between diets (P ≥ 0.23). Weight loss reduced hepatic fat, but there were no differences between groups (P ≥ 0.28). Dietary goals were not fully met; self-reported contrasts were closer to 2% protein, 8% fat, and 14% carbohydrate at 6 mo and 1%, 7%, and 10%, respectively, at 2 y. Conclusion: Participants lost more fat than lean mass after consumption of all diets, with no differences in changes in body composition, abdominal fat, or hepatic fat between assigned macronutrient amounts. This trial was registered at clinicaltrials.gov as NCT00072995. PMID:22258266

  1. Effects of 4 weight-loss diets differing in fat, protein, and carbohydrate on fat mass, lean mass, visceral adipose tissue, and hepatic fat: results from the POUNDS LOST trial.

    Science.gov (United States)

    de Souza, Russell J; Bray, George A; Carey, Vincent J; Hall, Kevin D; LeBoff, Meryl S; Loria, Catherine M; Laranjo, Nancy M; Sacks, Frank M; Smith, Steven R

    2012-03-01

    Weight loss reduces body fat and lean mass, but whether these changes are influenced by macronutrient composition of the diet is unclear. We determined whether energy-reduced diets that emphasize fat, protein, or carbohydrate differentially reduce total, visceral, or hepatic fat or preserve lean mass. In a subset of participants in a randomized trial of 4 weight-loss diets, body fat and lean mass (n = 424; by using dual-energy X-ray absorptiometry) and abdominal and hepatic fat (n = 165; by using computed tomography) were measured after 6 mo and 2 y. Changes from baseline were compared between assigned amounts of protein (25% compared with 15%) and fat (40% compared with 20%) and across 4 carbohydrate amounts (35% through 65%). At 6 mo, participants lost a mean (±SEM) of 4.2 ± 0.3 kg (12.4%) fat and 2.1 ± 0.3 kg (3.5%) lean mass (both P fat (P ≥ 0.34), or 65% and 35% carbohydrate (P ≥ 0.27). Participants lost 2.3 ± 0.2 kg (13.8%) abdominal fat: 1.5 ± 0.2 kg (13.6%) subcutaneous fat and 0.9 ± 0.1 kg (16.1%) visceral fat (all P fat than did men relative to total-body fat loss. Participants regained ~40% of these losses by 2 y, with no differences between diets (P ≥ 0.23). Weight loss reduced hepatic fat, but there were no differences between groups (P ≥ 0.28). Dietary goals were not fully met; self-reported contrasts were closer to 2% protein, 8% fat, and 14% carbohydrate at 6 mo and 1%, 7%, and 10%, respectively, at 2 y. Participants lost more fat than lean mass after consumption of all diets, with no differences in changes in body composition, abdominal fat, or hepatic fat between assigned macronutrient amounts. This trial was registered at clinicaltrials.gov as NCT00072995.

  2. Axially symmetric two-body problem in general relativity. III. Bondi mass loss and the failure of the quadrupole formula

    International Nuclear Information System (INIS)

    Cooperstock, F.I.; Hobill, D.W.

    1979-01-01

    Suggested difficulties and criticism regarding earlier work is addressed. It is demonstrated that the rate of gravitational energy loss from the authors' model free-fall system employing the widely accepted Bondi method agrees precisely with the results described in prior works. Origins of the breakdown of the quadrupole formalism for free fall, previously indicated, are now delineated in detail. The role of source structure in the energy loss rate re-emerges, bringing into question much of the earlier work of others. The iterative technique with flat-space wave operators is justified. A new approach to quasiperiodic systems such as binary stars is described. Ideally modeled upon the actual birth of such systems, it evolves from an initially stationary configuration, again avoiding the problems and ambiguities regarding incoming radiation

  3. Loss of Muscle Mass During Chemotherapy Is Predictive for Poor Survival of Patients With Metastatic Colorectal Cancer

    NARCIS (Netherlands)

    Blauwhoff-Buskermolen, Susanne; Versteeg, Kathelijn S.; de van der Schueren, Marian A. E.; den Braver, Nicole R.; Berkhof, Johannes; Langius, Jacqueline A. E.; Verheul, Henk M. W.

    2016-01-01

    Low muscle mass is present in approximately 40% of patients with metastatic colorectal cancer (mCRC) and may be associated with poor outcome. We studied change in skeletal muscle during palliative chemotherapy in patients with mCRC and its association with treatment modifications and overall

  4. Modelling Energy Loss Mechanisms and a Determination of the Electron Energy Scale for the CDF Run II W Mass Measurement

    Energy Technology Data Exchange (ETDEWEB)

    Riddick, Thomas [Univ. College London, Bloomsbury (United Kingdom)

    2012-06-15

    The calibration of the calorimeter energy scale is vital to measuring the mass of the W boson at CDF Run II. For the second measurement of the W boson mass at CDF Run II, two independent simulations were developed. This thesis presents a detailed description of the modification and validation of Bremsstrahlung and pair production modelling in one of these simulations, UCL Fast Simulation, comparing to both geant4 and real data where appropriate. The total systematic uncertainty on the measurement of the W boson mass in the W → eve channel from residual inaccuracies in Bremsstrahlung modelling is estimated as 6.2 ±3.2 MeV/c2 and the total systematic uncertainty from residual inaccuracies in pair production modelling is estimated as 2.8± 2.7 MeV=c2. Two independent methods are used to calibrate the calorimeter energy scale in UCL Fast Simulation; the results of these two methods are compared to produce a measurement of the Z boson mass as a cross-check on the accuracy of the simulation.

  5. URCA neutrino-loss rates under conditions found in the carbon-oxygen cores of intermediate-mass stars

    International Nuclear Information System (INIS)

    Iben, I. Jr.

    1978-01-01

    In the hope of uncovering additional Urca-active nuclei that might appear during carbon burning in the electron-degenerate carbon-oxygen core of an asymptotic-branch star and avert a thermonuclear runaway, a nuclear-reaction matrix connecting 244 nuclear species has been constructed. Analytic expressions for rates of all relevant β-transitions are also presented and used. It is shown that in matter which is composed initially of elements in a solar-system distribution and which has undergone first complete hydrogen burning and then complete helium burning, neutrino-loss rates due to 11 Urca pairs either rival or exceed neutrino losses predicted by the charge- and neutral-current theories of weak interactions. Most remarkably, no new Urca pairs of any consequence appear as a result of several thousand reactions that are allowed to occur during carbon burning. The dominant Urca-loss rates are still due to the pairs 21 F- 21 Ne, 23 Ne- 23 Na, 25 Na- 25 Mg, and 25 Ne- 25 Na, as in matter containing a solar-system distribution of elements that has undergone prior processing during hydrogen- and helium-burning phases. The abundances of these Urca-active pairs are enhanced by one to three orders of magnitude as a consequence of carbon-burning reactions

  6. Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence.

    Science.gov (United States)

    Tezze, Caterina; Romanello, Vanina; Desbats, Maria Andrea; Fadini, Gian Paolo; Albiero, Mattia; Favaro, Giulia; Ciciliot, Stefano; Soriano, Maria Eugenia; Morbidoni, Valeria; Cerqua, Cristina; Loefler, Stefan; Kern, Helmut; Franceschi, Claudio; Salvioli, Stefano; Conte, Maria; Blaauw, Bert; Zampieri, Sandra; Salviati, Leonardo; Scorrano, Luca; Sandri, Marco

    2017-06-06

    Mitochondrial dysfunction occurs during aging, but its impact on tissue senescence is unknown. Here, we find that sedentary but not active humans display an age-related decline in the mitochondrial protein, optic atrophy 1 (OPA1), that is associated with muscle loss. In adult mice, acute, muscle-specific deletion of Opa1 induces a precocious senescence phenotype and premature death. Conditional and inducible Opa1 deletion alters mitochondrial morphology and function but not DNA content. Mechanistically, the ablation of Opa1 leads to ER stress, which signals via the unfolded protein response (UPR) and FoxOs, inducing a catabolic program of muscle loss and systemic aging. Pharmacological inhibition of ER stress or muscle-specific deletion of FGF21 compensates for the loss of Opa1, restoring a normal metabolic state and preventing muscle atrophy and premature death. Thus, mitochondrial dysfunction in the muscle can trigger a cascade of signaling initiated at the ER that systemically affects general metabolism and aging. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  7. Losses of functional opsin genes, short-wavelength cone photopigments, and color vision--a significant trend in the evolution of mammalian vision.

    Science.gov (United States)

    Jacobs, Gerald H

    2013-03-01

    All mammalian cone photopigments are derived from the operation of representatives from two opsin gene families (SWS1 and LWS in marsupial and eutherian mammals; SWS2 and LWS in monotremes), a process that produces cone pigments with respective peak sensitivities in the short and middle-to-long wavelengths. With the exception of a number of primate taxa, the modal pattern for mammals is to have two types of cone photopigment, one drawn from each of the gene families. In recent years, it has been discovered that the SWS1 opsin genes of a widely divergent collection of eutherian mammals have accumulated mutational changes that render them nonfunctional. This alteration reduces the retinal complements of these species to a single cone type, thus rendering ordinary color vision impossible. At present, several dozen species from five mammalian orders have been identified as falling into this category, but the total number of mammalian species that have lost short-wavelength cones in this way is certain to be much larger, perhaps reaching as high as 10% of all species. A number of circumstances that might be used to explain this widespread cone loss can be identified. Among these, the single consistent fact is that the species so affected are nocturnal or, if they are not technically nocturnal, they at least feature retinal organizations that are typically associated with that lifestyle. At the same time, however, there are many nocturnal mammals that retain functional short-wavelength cones. Nocturnality thus appears to set the stage for loss of functional SWS1 opsin genes in mammals, but it cannot be the sole circumstance.

  8. SEARCHING FOR COOL DUST IN THE MID-TO-FAR INFRARED: THE MASS-LOSS HISTORIES OF THE HYPERGIANTS μ Cep, VY CMa, IRC+10420, AND ρ Cas

    Energy Technology Data Exchange (ETDEWEB)

    Shenoy, Dinesh; Humphreys, Roberta M.; Jones, Terry J.; Gehrz, Robert D. [Minnesota Institute for Astrophysics, School of Physics and Astronomy, University of Minnesota, 116 Church Street, SE, Minneapolis, MN 55455 (United States); Marengo, Massimo [Department of Physics, Iowa State University, Ames, IA 50011 (United States); Helton, L. Andrew [USRA-SOFIA Science Center, NASA Ames Research Center, Moffett Field, CA 94035 (United States); Hoffmann, William F.; Skemer, Andrew J.; Hinz, Philip M., E-mail: shenoy@astro.umn.edu [Department of Astronomy/Steward Observatory, University of Arizona, 933N. Cherry Avenue, Tucson, AZ 85721 (United States)

    2016-03-15

    We present mid- and far-IR imaging of four famous hypergiant stars: the red supergiants μ Cep and VY CMa, and the warm hypergiants IRC +10420 and ρ Cas. Our 11–37 μm SOFIA/FORCAST imaging probes cool dust not detected in visual and near-IR imaging studies. Adaptive optics 8–12 μm imaging of μ Cep and IRC +10420 with MMT/MIRAC reveals extended envelopes that are the likely sources of these stars’ strong silicate emission features. We find μ Cep’s mass-loss rate to have declined by about a factor of five over a 13,000 year history, ranging from 5 × 10{sup −6} down to ∼1× 10{sup −6} M{sub ⊙} yr{sup −1}. The morphology of VY CMa indicates a cooler dust component coincident with the highly asymmetric reflection nebulae seen in the visual and near-IR. The lack of cold dust at greater distances around VY CMa indicates that its mass-loss history is limited to the last ∼1200 years, with an average rate of 6 × 10{sup −4} M{sub ⊙} yr{sup −1}. We find two distinct periods in the mass-loss history of IRC +10420 with a high rate of 2 × 10{sup −3} M{sub ⊙} yr{sup −1} until approximately 2000 years ago, followed by an order of magnitude decrease in the recent past. We interpret this change as evidence of its evolution beyond the RSG stage. Our new infrared photometry of ρ Cas is consistent with emission from the expanding dust shell ejected in its 1946 eruption, with no evidence of newer dust formation from its more recent events.

  9. Less-than-expected weight loss in normal-weight women undergoing caloric restriction and exercise is accompanied by preservation of fat-free mass and metabolic adaptations.

    Science.gov (United States)

    Koehler, K; De Souza, M J; Williams, N I

    2017-03-01

    Normal-weight women frequently restrict their caloric intake and exercise, but little is known about the effects on body weight, body composition and metabolic adaptations in this population. We conducted a secondary analysis of data from a randomized controlled trial in sedentary normal-weight women. Women were assigned to a severe energy deficit (SEV: -1062±80 kcal per day; n=9), a moderate energy deficit (MOD: -633±71 kcal per day; n=7) or energy balance (BAL; n=9) while exercising five times per week for 3 months. Outcome variables included changes in body weight, body composition, resting metabolic rate (RMR) and metabolic hormones associated with energy conservation. Weight loss occurred in SEV (-3.7±0.9 kg, P0.33). RMR decreased by -6±2% in MOD (P=0.020). In SEV, RMR did not change on a group level (P=0.66), but participants whose RMR declined lost more weight (P=0.020) and had a higher baseline RMR (P=0.026) than those whose RMR did not decrease. Characteristic changes in leptin (P=0.003), tri-iodothyronine (P=0.013), insulin-like growth factor-1 (P=0.016) and ghrelin (P=0.049) occurred only in SEV. The energy deficit and adaptive changes in RMR explained 54% of the observed weight loss. In normal-weight women, caloric restriction and exercise resulted in less-than-predicted weight loss. In contrast to previous literature, weight loss consisted almost exclusively of fat mass, whereas fat-free mass was preserved.

  10. Improvement of transmission loss of a double panel by using active control with a virtual modal mass

    OpenAIRE

    Lhuillier , Vincent; Chesné , Simon; Gaudiller , Luc; Pezerat , Charles

    2013-01-01

    International audience; In this article, modal feedback control is proposed to reduce the sound transmission through finite double panels using lead zirconate titanate ceramic sensors and actuators bonded to the structure. Active control allows adding virtual modal damping and mass to the structure by the use of modal velocities and accelerations. In a first step, the equations describing the structure, the actuators, the acoustic excitation, and the acoustic radiation are detailed. Next, the...

  11. Extensive Loss of Islet Mass Beyond the First Day After Intraportal Human Islet Transplantation in a Mouse Model.

    Science.gov (United States)

    Liljebäck, Hanna; Grapensparr, Liza; Olerud, Johan; Carlsson, Per-Ola

    2016-01-01

    Clinical islet transplantation is characterized by a progressive deterioration of islet graft function, which renders many patients once again dependent on exogenous insulin administration within a couple of years. In this study, we aimed to investigate possible engraftment factors limiting the survival and viability of experimentally transplanted human islets beyond the first day after their transplantation to the liver. Human islets were transplanted into the liver of nude mice and characterized 1 or 30 days after transplantation by immunohistochemistry. The factors assessed were endocrine mass, cellular death, hypoxia, vascular density and amyloid formation in the transplanted islets. One day posttransplantation, necrotic cells, as well as apoptotic cells, were commonly observed. In contrast to necrotic death, apoptosis rates remained high 1 month posttransplantation, and the total islet mass was reduced by more than 50% between 1 and 30 days posttransplantation. Islet mass at 30 days posttransplantation correlated negatively to apoptotic death. Vascular density within the transplanted islets remained less than 30% of that in native human islets up to 30 days posttransplantation and was associated with prevailing hypoxia. Amyloid formation was rarely observed in the 1-day-old transplants, but was commonly observed in the 30-day-old islet transplants. We conclude that substantial islet cell death occurs beyond the immediate posttransplantation phase, particularly through apoptotic events. Concomitant low vascularization with prevailing hypoxia and progressive amyloid development was observed in the human islet grafts. Strategies to improve engraftment at the intraportal site or change of implantation site in the clinical setting are needed.

  12. Modeling, Analysis, and Control of a Hypersonic Vehicle with Significant Aero-Thermo-Elastic-Propulsion Interactions: Elastic, Thermal and Mass Uncertainty

    Science.gov (United States)

    Khatri, Jaidev

    This thesis examines themodeling, analysis, and control system design issues for scramjet powered hypersonic vehicles. A nonlinear three degrees of freedom longitudinal model which includes aero-propulsion-elasticity effects was used for all analyses. This model is based upon classical compressible flow and Euler-Bernouli structural concepts. Higher fidelity computational fluid dynamics and finite element methods are needed for more precise intermediate and final evaluations. The methods presented within this thesis were shown to be useful for guiding initial control relevant design. The model was used to examine the vehicle's static and dynamic characteristics over the vehicle's trimmable region. The vehicle has significant longitudinal coupling between the fuel equivalency ratio (FER) and the flight path angle (FPA). For control system design, a two-input two-output plant (FER - elevator to speed-FPA) with 11 states (including 3 flexible modes) was used. Velocity, FPA, and pitch were assumed to be available for feedback. Aerodynamic heat modeling and design for the assumed TPS was incorporated to original Bolender's model to study the change in static and dynamic properties. De-centralized control stability, feasibility and limitations issues were dealt with the change in TPS elasticity, mass and physical dimension. The impact of elasticity due to TPS mass, TPS physical dimension as well as prolonged heating was also analyzed to understand performance limitations of de-centralized control designed for nominal model.

  13. Clonal Evolution and Clinical Significance of Copy Number Neutral Loss of Heterozygosity of Chromosome Arm 6p in Acquired Aplastic Anemia

    Science.gov (United States)

    Betensky, Marisol; Babushok, Daria; Roth, Jacquelyn J.; Mason, Philip J; Biegel, Jaclyn A.; Busse, Tracy M; Li, Yimei; Lind, Curt; Papazoglou, Anna; Monos, Dimitri; Podsakoff, Gregory; Bessler, Monica; Olson, Timothy S.

    2015-01-01

    Acquired aplastic anemia (aAA) results from the T cell-mediated autoimmune destruction of hematopoietic stem cells. Factors predicting response to immune suppression therapy (IST) or development of myelodysplastic syndrome (MDS) are beginning to be elucidated. Our recent data suggest most patients with aAA treated with IST develop clonal somatic genetic alterations in hematopoietic cells. One frequent acquired abnormality is copy-number neutral loss of heterozygosity on chromosome 6p (6p CN-LOH) involving the human leukocyte antigen (HLA) locus. We hypothesized that because 6p CN-LOH clones may arise from selective pressure to escape immune surveillance through deletion of HLA alleles, the development of 6p CN-LOH may affect response to IST. We used single nucleotide polymorphism array genotyping and targeted next-generation sequencing of HLA alleles to assess frequency of 6p CN-LOH, identity of HLA alleles lost through 6p CN-LOH, and impact of 6p CN-LOH on response to IST. 6p CN-LOH clones were present in 11.3% of patients, remained stable over time, and were not associated with development of MDS-defining cytogenetic abnormalities. Notably, no patient with 6p CN-LOH treated with IST achieved a complete response. In summary, clonal 6p CN-LOH in aAA defines a unique subgroup of patients that may provide insights into hematopoietic clonal evolution. PMID:26702937

  14. Clonal evolution and clinical significance of copy number neutral loss of heterozygosity of chromosome arm 6p in acquired aplastic anemia.

    Science.gov (United States)

    Betensky, Marisol; Babushok, Daria; Roth, Jacquelyn J; Mason, Philip J; Biegel, Jaclyn A; Busse, Tracy M; Li, Yimei; Lind, Curt; Papazoglou, Anna; Monos, Dimitri; Podsakoff, Gregory; Bessler, Monica; Olson, Timothy S

    2016-01-01

    Acquired aplastic anemia (aAA) results from the T cell-mediated autoimmune destruction of hematopoietic stem cells. Factors predicting response to immune suppression therapy (IST) or development of myelodysplastic syndrome (MDS) are beginning to be elucidated. Our recent data suggest most patients with aAA treated with IST develop clonal somatic genetic alterations in hematopoietic cells. One frequent acquired abnormality is copy-number neutral loss of heterozygosity on chromosome 6p (6p CN-LOH) involving the human leukocyte antigen (HLA) locus. We hypothesized that because 6p CN-LOH clones may arise from selective pressure to escape immune surveillance through deletion of HLA alleles, the development of 6p CN-LOH may affect response to IST. We used single nucleotide polymorphism array genotyping and targeted next-generation sequencing of HLA alleles to assess frequency of 6p CN-LOH, identity of HLA alleles lost through 6p CN-LOH, and impact of 6p CN-LOH on response to IST. 6p CN-LOH clones were present in 11.3% of patients, remained stable over time, and were not associated with development of MDS-defining cytogenetic abnormalities. Notably, no patient with 6p CN-LOH treated with IST achieved a complete response. In summary, clonal 6p CN-LOH in aAA defines a unique subgroup of patients that may provide insights into hematopoietic clonal evolution. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Elevated removal of middle molecules without significant albumin loss with mixed-dilution hemodiafiltration for patients unable to provide sufficient blood flow rates.

    Science.gov (United States)

    Potier, Jacky; Le Roy, Frank; Faucon, Jean Paul; Besselièvre, Thibault; Renaudineau, Eric; Farquet, Christian; Soihan, Pascale; Touzard, Dominique; Djema, Asia; Ilinca, Toma

    2013-01-01

    We examined the hypothesis that mixed-dilution online hemodiafiltration (MIXED) rather than predilution online hemodiafiltration (PRE) could enable patients with low blood flow rate (Qb) to benefit from advantages of convective therapies. Thirty-eight patients were included in a prospective, randomized, crossover and multicenter study conducted with a view to comparing the equilibrated Kt/V, reduction ratio (RR) of phosphates, β2-microglobulin (β2-M) and myoglobin (myo) between PRE and MIXED, each at two Qb values of 250 and 300 ml/min during 4 h sessions with a FX1000HDF dialyzer. Albumin losses (Alb) were also measured in 12 patients. MIXED was always found to be more efficient compared to PRE notably for middle molecules (MM). RRβ2-M: MIX250: 81.3 ± 3.6 vs. PRE250: 75.2 ± 5.9; MIX300: 82.7 ± 3.6 vs. PRE300: 78.1 ± 5.4; RRmyo: MIX250: 70.2 ± 3.6 vs. PRE250: 42.6 ± 2.6; MIX300: 70.6 ± 3.6 vs. PRE300: 45.7 ± 3.6 and with Alb <3.0 g/session. MIXED allows patients unable to provide sufficiently high Qb to achieve high levels of MM removal. © 2013 S. Karger AG, Basel.

  16. Effects of breakfast eating and eating frequency on body mass index and weight loss outcomes in adults enrolled in an obesity treatment program.

    Science.gov (United States)

    Megson, Maureen; Wing, Rena; Leahey, Tricia M

    2017-08-01

    This study examined the effects of breakfast eating and eating frequency on objectively assessed BMI and weight loss outcomes among adults enrolled in obesity treatment. Participants completed measures of breakfast eating and eating frequency before and after treatment and had their height and weight measured. Baseline breakfast eating and eating frequency were not associated with baseline BMI (p = .34, p = .45, respectively) and did not predict weight loss during treatment (p = .36, p = .58, respectively). From pre- to post-treatment, there was no significant change in eating frequency (p = .27) and changes in eating frequency had no impact on weight loss (r = -.08, p = .23). However, increases in breakfast eating during treatment were associated with significantly better weight loss outcomes (r = .26, p eating, those who had either no change or a decrease in daily eating frequency were more likely to achieve a 5% weight loss compared to those who had an increase in daily eating frequency (p = .04). These results suggest that increasing breakfast eating, while simultaneously reducing or keeping eating frequency constant, may improve outcomes in obesity treatment. Experimental studies are needed to further elucidate these effects.

  17. LIGHT CURVES OF CORE-COLLAPSE SUPERNOVAE WITH SUBSTANTIAL MASS LOSS USING THE NEW OPEN-SOURCE SUPERNOVA EXPLOSION CODE (SNEC)

    International Nuclear Information System (INIS)

    Morozova, Viktoriya; Renzo, Mathieu; Ott, Christian D.; Clausen, Drew; Couch, Sean M.; Ellis, Justin; Roberts, Luke F.; Piro, Anthony L.

    2015-01-01

    We present the SuperNova Explosion Code (SNEC), an open-source Lagrangian code for the hydrodynamics and equilibrium-diffusion radiation transport in the expanding envelopes of supernovae. Given a model of a progenitor star, an explosion energy, and an amount and distribution of radioactive nickel, SNEC generates the bolometric light curve, as well as the light curves in different broad bands assuming blackbody emission. As a first application of SNEC, we consider the explosions of a grid of 15 M ⊙ (at zero-age main sequence, ZAMS) stars whose hydrogen envelopes are stripped to different extents and at different points in their evolution. The resulting light curves exhibit plateaus with durations of ∼20–100 days if ≳1.5–2 M ⊙ of hydrogen-rich material is left and no plateau if less hydrogen-rich material is left. If these shorter plateau lengths are not seen for SNe IIP in nature, it suggests that, at least for ZAMS masses ≲20 M ⊙ , hydrogen mass loss occurs as an all or nothing process. This perhaps points to the important role binary interactions play in generating the observed mass-stripped supernovae (i.e., Type Ib/c events). These light curves are also unlike what is typically seen for SNe IIL, arguing that simply varying the amount of mass loss cannot explain these events. The most stripped models begin to show double-peaked light curves similar to what is often seen for SNe IIb, confirming previous work that these supernovae can come from progenitors that have a small amount of hydrogen and a radius of ∼500 R ⊙

  18. LIGHT CURVES OF CORE-COLLAPSE SUPERNOVAE WITH SUBSTANTIAL MASS LOSS USING THE NEW OPEN-SOURCE SUPERNOVA EXPLOSION CODE (SNEC)

    Energy Technology Data Exchange (ETDEWEB)

    Morozova, Viktoriya; Renzo, Mathieu; Ott, Christian D.; Clausen, Drew; Couch, Sean M.; Ellis, Justin; Roberts, Luke F. [TAPIR, Walter Burke Institute for Theoretical Physics, MC 350-17, California Institute of Technology, Pasadena, CA 91125 (United States); Piro, Anthony L., E-mail: morozvs@tapir.caltech.edu [Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101 (United States)

    2015-11-20

    We present the SuperNova Explosion Code (SNEC), an open-source Lagrangian code for the hydrodynamics and equilibrium-diffusion radiation transport in the expanding envelopes of supernovae. Given a model of a progenitor star, an explosion energy, and an amount and distribution of radioactive nickel, SNEC generates the bolometric light curve, as well as the light curves in different broad bands assuming blackbody emission. As a first application of SNEC, we consider the explosions of a grid of 15 M{sub ⊙} (at zero-age main sequence, ZAMS) stars whose hydrogen envelopes are stripped to different extents and at different points in their evolution. The resulting light curves exhibit plateaus with durations of ∼20–100 days if ≳1.5–2 M{sub ⊙} of hydrogen-rich material is left and no plateau if less hydrogen-rich material is left. If these shorter plateau lengths are not seen for SNe IIP in nature, it suggests that, at least for ZAMS masses ≲20 M{sub ⊙}, hydrogen mass loss occurs as an all or nothing process. This perhaps points to the important role binary interactions play in generating the observed mass-stripped supernovae (i.e., Type Ib/c events). These light curves are also unlike what is typically seen for SNe IIL, arguing that simply varying the amount of mass loss cannot explain these events. The most stripped models begin to show double-peaked light curves similar to what is often seen for SNe IIb, confirming previous work that these supernovae can come from progenitors that have a small amount of hydrogen and a radius of ∼500 R{sub ⊙}.

  19. The contribution to future flood risk in the Severn Estuary from extreme sea level rise due to ice sheet mass loss

    Science.gov (United States)

    Quinn, N.; Bates, P. D.; Siddall, M.

    2013-12-01

    The rate at which sea levels will rise in the coming century is of great interest to decision makers tasked with developing mitigation policies to cope with the risk of coastal inundation. Accurate estimates of future sea levels are vital in the provision of effective policy. Recent reports from UK Climate Impacts Programme (UKCIP) suggest that mean sea levels in the UK may rise by as much as 80 cm by 2100; however, a great deal of uncertainty surrounds model predictions, particularly the contribution from ice sheets responding to climatic warming. For this reason, the application of semi-empirical modelling approaches for sea level rise predictions has increased of late, the results from which suggest that the rate of sea level rise may be greater than previously thought, exceeding 1 m by 2100. Furthermore, studies in the Red Sea indicate that rapid sea level rise beyond 1m per century has occurred in the past. In light of such research, the latest UKCIP assessment has included a H++ scenario for sea level rise in the UK of up to 1.9 m which is defined as improbable but, crucially, physically plausible. The significance of such low-probability sea level rise scenarios upon the estimation of future flood risk is assessed using the Somerset levels (UK) as a case study. A simple asymmetric probability distribution is constructed to include sea level rise scenarios of up to 1.9 m by 2100 which are added to a current 1:200 year event water level to force a two-dimensional hydrodynamic model of coastal inundation. From the resulting ensemble predictions an estimation of risk by 2100 is established. The results indicate that although the likelihood of extreme sea level rise due to rapid ice sheet mass loss is low, the resulting hazard can be large, resulting in a significant (27%) increase to the projected annual risk. Furthermore, current defence construction guidelines for the coming century in the UK are expected to account for 95% of the sea level rise distribution

  20. Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4+ T cell loss is associated with double-negative T cells

    Science.gov (United States)

    Milush, Jeffrey M.; Mir, Kiran D.; Sundaravaradan, Vasudha; Gordon, Shari N.; Engram, Jessica; Cano, Christopher A.; Reeves, Jacqueline D.; Anton, Elizabeth; O’Neill, Eduardo; Butler, Eboneé; Hancock, Kathy; Cole, Kelly S.; Brenchley, Jason M.; Else, James G.; Silvestri, Guido; Sodora, Donald L.

    2011-01-01

    SIV infection of natural host species such as sooty mangabeys results in high viral replication without clinical signs of simian AIDS. Studying such infections is useful for identifying immunologic parameters that lead to AIDS in HIV-infected patients. Here we have demonstrated that acute, SIV-induced CD4+ T cell depletion in sooty mangabeys does not result in immune dysfunction and progression to simian AIDS and that a population of CD3+CD4–CD8– T cells (double-negative T cells) partially compensates for CD4+ T cell function in these animals. Passaging plasma from an SIV-infected sooty mangabey with very few CD4+ T cells to SIV-negative animals resulted in rapid loss of CD4+ T cells. Nonetheless, all sooty mangabeys generated SIV-specific antibody and T cell responses and maintained normal levels of plasma lipopolysaccharide. Moreover, all CD4-low sooty mangabeys elicited a de novo immune response following influenza vaccination. Such preserved immune responses as well as the low levels of immune activation observed in these animals were associated with the presence of double-negative T cells capable of producing Th1, Th2, and Th17 cytokines. These studies indicate that SIV-infected sooty mangabeys do not appear to rely entirely on CD4+ T cells to maintain immunity and identify double-negative T cells as a potential subset of cells capable of performing CD4+ T cell–like helper functions upon SIV-induced CD4+ T cell depletion in this species. PMID:21317533

  1. Physiological effects beyond the significant gain in muscle mass in sarcopenic elderly men: evidence from a randomized clinical trial using a protein-rich food

    Directory of Open Access Journals (Sweden)

    Alemán-Mateo H

    2012-07-01

    Full Text Available Heliodoro Alemán-Mateo,1 Liliana Macías,1 Julián Esparza-Romero,1 Humberto Astiazaran-García,1 Ana Luz Blancas21Coordinación de Nutrición, Centro de Investigación en Alimentación y Desarrollo, AC, Hermosillo, Sonora, México; 2Dirección General de Servicios de Salud a la Persona, Hermosillo, Sonora, MéxicoBackground: Sarcopenia is strongly associated with an inadequate intake of dietary protein. Dietary protein supplementation boosts muscle-protein synthesis and increases muscle mass in the elderly. This study tested whether adding a protein-rich food, ricotta cheese, to the habitual diet increased total appendicular skeletal muscle mass and strength in elderly people.Methods: Participants (n = 40, were sarcopenic elderly men and women over 60 years of age. Two comparison groups were formed at random and followed for 3 months: the intervention group received 210 g/day of ricotta cheese plus the habitual diet, while the control group followed the habitual diet with no additional intervention. Total appendicular skeletal muscle (TASM was assessed by dual-energy X-ray absorptiometry, while strength was measured using a handheld dynamometer at baseline and after the intervention period. The primary outcomes were the percentage of relative change in TASM and strength.Results: The percentage of relative change in TASM was not significant between the groups after the intervention period. Muscle strength improved in the intervention group, but showed only a tendency towards significance (P = 0.06. Secondary analysis showed that the men in the intervention group gained 270 g in TASM compared to those in the control group, and improved their fasting insulin levels (P = 0.05, muscle strength, lean body mass in the arms, and body weight variables.Conclusion: The results of this study indicate that a nutritional intervention using a high-quality protein food, specifically ricotta cheese, in order to increase the amount of protein intake might not

  2. Significant correlations between optic nerve head microcirculation and visual field defects and nerve fiber layer loss in glaucoma patients with myopic glaucomatous disk

    Directory of Open Access Journals (Sweden)

    Yokoyama Y

    2011-12-01

    Full Text Available Yu Yokoyama, Naoko Aizawa, Naoki Chiba, Kazuko Omodaka, Masahiko Nakamura, Takaaki Otomo, Shunji Yokokura, Nobuo Fuse, Toru NakazawaDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, JapanBackground: Eyes with glaucoma are characterized by optic neuropathy with visual field defects in the areas corresponding to the optic disk damage. The exact cause for the glaucomatous optic neuropathy has not been determined. Myopia has been shown to be a risk factor for glaucoma. The purpose of this study was to determine whether a significant correlation existed between the microcirculation of the optic disk and the visual field defects and the retinal nerve fiber layer thickness (RNFLT in glaucoma patients with myopic optic disks.Methods: Sixty eyes of 60 patients with myopic disks were studied; 36 eyes with glaucoma (men:women = 19:17 and 24 eyes with no ocular diseases (men:women = 14:10. The mean deviation (MD determined by the Humphrey field analyzer, and the peripapillary RNFLT determined by the Stratus-OCT were compared between the two groups. The ocular circulation was determined by laser speckle flowgraphy (LSFG, and the mean blur rate (MBR was compared between the two groups. The correlations between the RNFLT and MBR of the corresponding areas of the optic disk and between MD and MBR of the optic disk in the glaucoma group were determined by simple regression analyses.Results: The average MBR for the entire optic disk was significantly lower in the glaucoma group than that in the control group. The differences of the MBR for the tissue in the superior, inferior, and temporal quadrants of the optic disk between the two groups were significant. The MBR for the entire optic disk was significantly correlated with the MD (r = 0.58, P = 0.0002 and the average RNFLT (r = 0.53, P = 0.0008. The tissue MBR of the optic disk was significantly correlated with the RNFLT in the superior, inferior, and temporal quadrants

  3. The In Vitro Mass-Produced Model Mycorrhizal Fungus, Rhizophagus irregularis, Significantly Increases Yields of the Globally Important Food Security Crop Cassava

    Science.gov (United States)

    Ceballos, Isabel; Ruiz, Michael; Fernández, Cristhian; Peña, Ricardo

    2013-01-01

    The arbuscular mycorrhizal symbiosis is formed between arbuscular mycorrhizal fungi (AMF) and plant roots. The fungi provide the plant with inorganic phosphate (P). The symbiosis can result in increased plant growth. Although most global food crops naturally form this symbiosis, very few studies have shown that their practical application can lead to large-scale increases in food production. Application of AMF to crops in the tropics is potentially effective for improving yields. However, a main problem of using AMF on a large-scale is producing cheap inoculum in a clean sterile carrier and sufficiently concentrated to cheaply transport. Recently, mass-produced in vitro inoculum of the model mycorrhizal fungus Rhizophagus irregularis became available, potentially making its use viable in tropical agriculture. One of the most globally important food plants in the tropics is cassava. We evaluated the effect of in vitro mass-produced R. irregularis inoculum on the yield of cassava crops at two locations in Colombia. A significant effect of R. irregularis inoculation on yield occurred at both sites. At one site, yield increases were observed irrespective of P fertilization. At the other site, inoculation with AMF and 50% of the normally applied P gave the highest yield. Despite that AMF inoculation resulted in greater food production, economic analyses revealed that AMF inoculation did not give greater return on investment than with conventional cultivation. However, the amount of AMF inoculum used was double the recommended dose and was calculated with European, not Colombian, inoculum prices. R. irregularis can also be manipulated genetically in vitro, leading to improved plant growth. We conclude that application of in vitro R. irregularis is currently a way of increasing cassava yields, that there is a strong potential for it to be economically profitable and that there is enormous potential to improve this efficiency further in the future. PMID:23950975

  4. The in vitro mass-produced model mycorrhizal fungus, Rhizophagus irregularis, significantly increases yields of the globally important food security crop cassava.

    Directory of Open Access Journals (Sweden)

    Isabel Ceballos

    Full Text Available The arbuscular mycorrhizal symbiosis is formed between arbuscular mycorrhizal fungi (AMF and plant roots. The fungi provide the plant with inorganic phosphate (P. The symbiosis can result in increased plant growth. Although most global food crops naturally form this symbiosis, very few studies have shown that their practical application can lead to large-scale increases in food production. Application of AMF to crops in the tropics is potentially effective for improving yields. However, a main problem of using AMF on a large-scale is producing cheap inoculum in a clean sterile carrier and sufficiently concentrated to cheaply transport. Recently, mass-produced in vitro inoculum of the model mycorrhizal fungus Rhizophagus irregularis became available, potentially making its use viable in tropical agriculture. One of the most globally important food plants in the tropics is cassava. We evaluated the effect of in vitro mass-produced R. irregularis inoculum on the yield of cassava crops at two locations in Colombia. A significant effect of R. irregularis inoculation on yield occurred at both sites. At one site, yield increases were observed irrespective of P fertilization. At the other site, inoculation with AMF and 50% of the normally applied P gave the highest yield. Despite that AMF inoculation resulted in greater food production, economic analyses revealed that AMF inoculation did not give greater return on investment than with conventional cultivation. However, the amount of AMF inoculum used was double the recommended dose and was calculated with European, not Colombian, inoculum prices. R. irregularis can also be manipulated genetically in vitro, leading to improved plant growth. We conclude that application of in vitro R. irregularis is currently a way of increasing cassava yields, that there is a strong potential for it to be economically profitable and that there is enormous potential to improve this efficiency further in the future.

  5. Significance of Additional Non-Mass Enhancement in Patients with Breast Cancer on Preoperative 3T Dynamic Contrast Enhanced MRI of the Breast

    International Nuclear Information System (INIS)

    Cho, Yun Hee; Cho, Kyu Ran; Park, Eun Kyung; Seo, Bo Kyoung; Woo, Ok Hee; Cho, Sung Bum; Bae, Jeoung Won

    2016-01-01

    In preoperative assessment of breast cancer, MRI has been shown to identify more additional breast lesions than are detectable using conventional imaging techniques. The characterization of additional lesions is more important than detection for optimal surgical treatment. Additional breast lesions can be included in focus, mass, and non-mass enhancement (NME) on MRI. According to the fifth edition of the breast imaging reporting and data system (BI-RADS®), which includes several changes in the NME descriptors, few studies to date have evaluated NME in preoperative assessment of breast cancer. We investigated the diagnostic accuracy of BI-RADS descriptors in predicting malignancy for additional NME lesions detected on preoperative 3T dynamic contrast enhanced MRI (DCE-MRI) in patients with newly diagnosed breast cancer. Between January 2008 and December 2012, 88 patients were enrolled in our study, all with NME lesions other than the index cancer on preoperative 3T DCE-MRI and all with accompanying histopathologic examination. The MRI findings were analyzed according to the BI-RADS MRI lexicon. We evaluated the size, distribution, internal enhancement pattern, and location of NME lesions relative to the index cancer (i.e., same quadrant, different quadrant, or contralateral breast). On histopathologic analysis of the 88 NME lesions, 73 (83%) were malignant and 15 (17%) were benign. Lesion size did not differ significantly between malignant and benign lesions (P = 0.410). Malignancy was more frequent in linear (P = 0.005) and segmental (P = 0.011) distributions, and benignancy was more frequent in focal (P = 0.004) and regional (P < 0.001) NME lesions. The highest positive predictive value (PPV) for malignancy occurred in segmental (96.8%), linear (95.1%), clustered ring (100%), and clumped (92.0%) enhancement. Asymmetry demonstrated a high positive predictive value of 85.9%. The frequency of malignancy was higher for NME lesions located in the same quadrant with

  6. Structure and evolution of the drainage system of a Himalayan debris-covered glacier, and its relationship with patterns of mass loss

    Science.gov (United States)

    Benn, Douglas I.; Thompson, Sarah; Gulley, Jason; Mertes, Jordan; Luckman, Adrian; Nicholson, Lindsey

    2017-09-01

    We provide the first synoptic view of the drainage system of a Himalayan debris-covered glacier and its evolution through time, based on speleological exploration and satellite image analysis of Ngozumpa Glacier, Nepal. The drainage system has several linked components: (1) a seasonal subglacial drainage system below the upper ablation zone; (2) supraglacial channels, allowing efficient meltwater transport across parts of the upper ablation zone; (3) sub-marginal channels, allowing long-distance transport of meltwater; (4) perched ponds, which intermittently store meltwater prior to evacuation via the englacial drainage system; (5) englacial cut-and-closure conduits, which may undergo repeated cycles of abandonment and reactivation; and (6) a "base-level" lake system (Spillway Lake) dammed behind the terminal moraine. The distribution and relative importance of these elements has evolved through time, in response to sustained negative mass balance. The area occupied by perched ponds has expanded upglacier at the expense of supraglacial channels, and Spillway Lake has grown as more of the glacier surface ablates to base level. Subsurface processes play a governing role in creating, maintaining, and shutting down exposures of ice at the glacier surface, with a major impact on spatial patterns and rates of surface mass loss. Comparison of our results with observations on other glaciers indicate that englacial drainage systems play a key role in the response of debris-covered glaciers to sustained periods of negative mass balance.

  7. Benefits of Group Living Include Increased Feeding Efficiency and Lower Mass Loss during Desiccation in the Social and Inbreeding Spider Stegodyphus dumicola

    Science.gov (United States)

    Vanthournout, Bram; Greve, Michelle; Bruun, Anne; Bechsgaard, Jesper; Overgaard, Johannes; Bilde, Trine

    2016-01-01

    Group living carries a price: it inherently entails increased competition for resources and reproduction, and may also be associated with mating among relatives, which carries costs of inbreeding. Nonetheless, group living and sociality is found in many animals, and understanding the direct and indirect benefits of cooperation that override the inherent costs remains a challenge in evolutionary ecology. Individuals in groups may benefit from more efficient management of energy or water reserves, for example in the form of reduced water or heat loss from groups of animals huddling, or through reduced energy demands afforded by shared participation in tasks. We investigated the putative benefits of group living in the permanently social spider Stegodyphus dumicola by comparing the effect of group size on standard metabolic rate, lipid/protein content as a body condition measure, feeding efficiency, per capita web investment, and weight/water loss and survival during desiccation. Because energetic expenditure is temperature sensitive, some assays were performed under varying temperature conditions. We found that feeding efficiency increased with group size, and the rate of weight loss was higher in solitary individuals than in animals in groups of various sizes during desiccation. Interestingly, this was not translated into differences in survival or in standard metabolic rate. We did not detect any group size effects for other parameters, and group size effects did not co-vary with experimental temperature in a predictive manner. Both feeding efficiency and mass loss during desiccation are relevant ecological factors as the former results in lowered predator exposure time, and the latter benefits social spiders which occupy arid, hot environments. PMID:26869936

  8. Benefits of group living include increased feeding efficiency and lower mass loss during desiccation in the social and inbreeding spider Stegodyphus dumicola.

    Directory of Open Access Journals (Sweden)

    Bram eVanthournout

    2016-02-01

    Full Text Available Group living carries a price: it inherently entails increased competition for resources and reproduction, and may also be associated with mating among relatives, which carries costs of inbreeding. Nonetheless, group living and sociality is found in many animals, and understanding the direct and indirect benefits of cooperation that override the inherent costs remains a challenge in evolutionary ecology. Individuals in groups may benefit from more efficient management of energy or water reserves, for example in the form of reduced water or heat loss from groups of animals huddling, or through reduced energy demands afforded by shared participation in tasks. We investigated the putative benefits of group living in the permanently social spider Stegodyphus dumicola by comparing the effect of group size on standard metabolic rate, lipid/protein content as a body condition measure, feeding efficiency, per capita web investment and weight/water loss and survival during desiccation. Because energetic expenditure is temperature sensitive, some assays were performed under varying temperature conditions. We found that feeding efficiency increased with group size, and the rate of weight loss was higher in solitary individuals than in animals in groups of various sizes during desiccation. Interestingly, this was not translated into differences in survival or in standard metabolic rate. We did not detect any group size effects for other parameters, and group size effects did not co-vary with experimental temperature in a predictive manner. Both feeding efficiency and mass loss during desiccation are relevant ecological factors as the former results in lowered predator exposure time, and the latter benefits social spiders which occupy arid, hot environments.

  9. Coastal conduit in southwestern Hudson Bay (Canada) in summer: Rapid transit of freshwater and significant loss of colored dissolved organic matter

    Science.gov (United States)

    Granskog, Mats A.; MacDonald, Robie W.; Kuzyk, Zou Zou A.; Senneville, Simon; Mundy, Christopher-John; Barber, David G.; Stern, Gary A.; Saucier, Francois

    2009-08-01

    Distributions of freshwater (sea-ice melt and runoff) were investigated along inshore-offshore sections in southwestern Hudson Bay for fall conditions. Conductivity-temperature-density profiles and bottle samples collected for salinity, oxygen isotope (δ18O), and colored dissolved organic matter (CDOM) analyses were used to discriminate between contributions of river water (RW) and sea-ice melt (SIM). Stations had a fresh summer surface mixed layer 5-25 m thick overlying a cold subsurface layer indicative of the previous winter's polar mixed layer (PML). The fraction of RW decreased strongly with distance from shore, while the opposite was true for SIM. The majority of RW was constrained in a coastal domain within 100-150 km from shore, which, because of high alongshore velocities, accounts for the majority of freshwater and volume transports. On the basis of freshwater inventories and composition, brine and RW accumulate in the PML over winter because of ice formation and downward mixing. The summer surface circulation results in an annual net export of SIM from the region. Residence times for freshwater components in the southwestern sector of the bay, based on currents derived from a 3-D ocean model for Hudson Bay, are about 1-10 months, implying rapid transit of freshwater. Despite the short residence time for RW (1-3 months), CDOM is significantly photobleached and provides an unreliable tracer for RW. Photobleaching represents an important sink for dissolved organic carbon entering from rivers and could, in part, explain why Hudson Bay is only a minor sink for atmospheric CO2 in the open water season.

  10. In vivo polymerization of poly(3,4-ethylenedioxythiophene) in the living rat hippocampus does not cause a significant loss of performance in a delayed alternation task

    Science.gov (United States)

    Ouyang, Liangqi; Shaw, Crystal L.; Kuo, Chin-chen; Griffin, Amy L.; Martin, David C.

    2014-04-01

    -polymerization time intervals, the polymerization did not cause significant deficits in performance of the DA task, suggesting that hippocampal function was not impaired by PEDOT deposition. However, GFAP+ and ED-1+ cells were also found at the deposition two weeks after the polymerization, suggesting potential secondary scarring. Therefore, less extensive deposition or milder deposition conditions may be desirable to minimize this scarring while maintaining decreased system impedance.

  11. ALMA Compact Array observations of the Fried Egg nebula: Evidence for large-scale asymmetric mass-loss from the yellow hypergiant IRAS 17163-3907.

    Science.gov (United States)

    Wallström, S H J; Lagadec, E; Muller, S; Black, J H; Cox, N L J; Galván-Madrid, R; Justtanont, K; Longmore, S; Olofsson, H; Oudmaijer, R D; Quintana-Lacaci, G; Szczerba, R; Vlemmings, W; van Winckel, H; Zijlstra, A

    2017-01-10

    Yellow hypergiants are rare and represent a fast evolutionary stage of massive evolved stars. That evolutionary phase is characterised by a very intense mass loss, the understanding of which is still very limited. Here we report ALMA Compact Array observations of a 50″-mosaic toward the Fried Egg nebula, around one of the few Galactic yellow hypergiants IRAS 17163-3907. The emission from the 12 CO J=2-1 line, H30 α recombination line, and continuum is imaged at a resolution of ~8″, revealing the morphology of the molecular environment around the star. The continuum emission is unresolved and peaks at the position of the star. The radio recombination line H30 α shows unresolved emission at the star, with an approximately gaussian spectrum centered on a velocity of 21±3 km s -1 with a width of 57±6 km s -1 . In contrast, the CO 2-1 emission is complex and decomposes into several components beyond the contamination from interstellar gas in the line of sight. The CO spectrum toward the star is a broad plateau, centered at the systemic velocity of +18 km s -1 and with an expansion velocity of 100±10 km s -1 . Assuming isotropic and constant mass-loss, we estimate a mass-loss rate of 8±1.5 ×10 -5 M ⊙ yr -1 . At a radius of 25″ from the star, we detect CO emission associated with the dust ring previously imaged by Herschel . The kinematics of this ring, however, is not consistent with an expanding shell, but show a velocity gradient of v sys ±20 km s -1 . In addition, we find a puzzling bright feature radially connecting the star to the CO ring, at a velocity of +40 km s -1 relative to the star. This spur feature may trace a unidirectional ejection event from the star. Our ACA observations reveal the complex morphology around IRAS 17163 and illustrate the breakthroughs that ALMA will bring to the field of massive stellar evolution.

  12. A mass shooting at Port Arthur, Tasmania, Australia: a study of its impact on early pregnancy losses using a conception time-based methodology.

    Science.gov (United States)

    Dean, R G; Dean, J; Heller, G Z; Leader, L R

    2015-11-01

    Does an acute calamity in a community cause early miscarriage and is this association the same for male and female fetuses? Estimated losses of 29.5% of first trimester pregnancies in the affected region could be associated with an acute calamity, with no statistically significant difference in estimated losses by fetal sex. There are very few studies on the impact of a calamity on early pregnancy loss and its differential effects on male and female fetuses. A decline in the human sex ratio at birth associated with the events of 9/11 in New York has been documented. This is a retrospective descriptive study of birth register data in Tasmania, Australia, from 1991 to 1997, covering the period in which the calamity occurred. The register contains data on all pregnancies that proceeded to >20 weeks gestation. The conception date was calculated by subtracting gestational age from birth date. We estimated that 40 318 pregnancies were conceived in the period 1991-1996 inclusive. These were aggregated to 4-weekly blocks classified by region and sex. The acute calamity was at Port Arthur, Tasmania, Australia. On 28 April 1996, a gunman opened fire on visitors and staff in a tourist cafe. A very stressful 20 h period, ended with 35 people dead and 22 injured. A negative binomial regression model was used to assess the association between this calamity and pregnancy loss. This loss is evidenced by a shortfall in the registration of pregnancies that were in their first trimester at the time of the calamity. We estimated a shortfall of 29.5% or 229 registered pregnancies among those in the first trimester at the time of the calamity (P surrogate for geographic area or space assumes that the mother has not moved into the postcode area after the calamity and before the reporting of a birth. The results of this study suggest that calamities bring about significant pregnancy loss affecting both sexes. The methodology presented of inferring conception date from birth date and using

  13. Increase in transmission loss of a double panel system by addition of mass inclusions to a poro-elastic layer: A comparison between theory and experiment

    Science.gov (United States)

    Idrisi, Kamal; Johnson, Marty E.; Toso, Alessandro; Carneal, James P.

    2009-06-01

    This paper is concerned with the modeling and optimization of heterogeneous (HG) blankets, which are used in this investigation to reduce the sound transmission through double panel systems. HG blankets consist of poro-elastic media with small embedded masses, which act similarly to a distributed mass-spring-damper-system. HG blankets have shown significant potential to reduce low frequency radiated sound from structures, where traditional poro-elastic materials have little effect. A mathematical model of a double panel system with an acoustic cavity and HG blanket was developed using impedance and mobility methods. The predicted responses of the source and the receiving panel due to a point force are validated with experimental measurements. The presented results indicate that proper tuning of the HG blankets can result in broadband noise reduction below 500 Hz with less than 10% added mass.

  14. THE MASS-LOSS RETURN FROM EVOLVED STARS TO THE LARGE MAGELLANIC CLOUD. II. DUST PROPERTIES FOR OXYGEN-RICH ASYMPTOTIC GIANT BRANCH STARS

    International Nuclear Information System (INIS)

    Sargent, Benjamin A.; Meixner, M.; Gordon, Karl D.; Srinivasan, S.; Kemper, F.; Woods, Paul M.; Tielens, A. G. G. M.; Speck, A. K.; Matsuura, M.; Bernard, J.-Ph.; Hony, S.; Indebetouw, R.; Marengo, M.; Sloan, G. C.

    2010-01-01

    900 K and 430 K, respectively, and with optical depths at 10 μm through the shells of 0.095 and 0.012, respectively. The models compute the dust mass-loss rates for the two stars to be 2.0 x 10 -9 M sun yr -1 and 2.3 x 10 -9 M sun yr -1 , respectively. When a dust-to-gas mass ratio of 0.002 is assumed for SSTSAGE052206 and HV 5715, the dust mass-loss rates imply total mass-loss rates of 1.0 x 10 -6 M sun yr -1 and 1.2 x 10 -6 M sun yr -1 , respectively. These properties of the dust shells and stars, as inferred from our models of the two stars, are found to be consistent with properties observed or assumed by detailed studies of other O-rich AGB stars in the LMC and elsewhere.

  15. Change in fat-free mass assessed by bioelectrical impedance, total body potassium and dual energy X-ray absorptiometry during prolonged weight loss

    DEFF Research Database (Denmark)

    Hendel, H W; Gotfredsen, A; Højgaard, L

    1996-01-01

    ). These measurements were compared with bioimpedance analysis (BIA) by applying 11 predictive BIA equations published in the literature. Predictive equations for the present study population were developed, with the use of fat-free mass (FFM) as assessed by TBK and DXA as references in multiple regression analysis....... The results of the BIA equations varied widely; FFM was generally overestimated by BIA as compared with DXA and TBK before and after weight loss. During weight loss, the FFM did not change, as estimated by DXA (1.3 +/- 2.3 kg, p > 0.05) and TBK (0.9 +/- 2.9 kg, p > 0.05). The recorded change in impedance (R......) was also insignificant. Three BIA equations from the literature, which were not specific for the degree of obesity in the present study group, predicted changes in FFM (from 0.5 + 3.6 to 2.4 +/- 4.4kg, p > 0.05) that were comparable with those estimated by the reference methods. Eight equations from...

  16. Clinical significance of coryneform Gram-positive rods from blood identified by MALDI-TOF mass spectrometry and their susceptibility profiles - a retrospective chart review.

    Science.gov (United States)

    Mushtaq, Ammara; Chen, Derrick J; Strand, Gregory J; Dylla, Brenda L; Cole, Nicolynn C; Mandrekar, Jayawant; Patel, Robin

    2016-07-01

    With the advent of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), most Gram-positive rods (GPRs) are readily identified; however, their clinical relevance in blood cultures remains unclear. Herein, we assessed the clinical significance of GPRs isolated from blood and identified in the era of MALDI-TOF MS. A retrospective chart review of patients presenting to the Mayo Clinic, Rochester, MN, from January 1, 2013, to October 13, 2015, was performed. Any episode of a positive blood culture for a GPR was included. We assessed the number of bottles positive for a given isolate, time to positivity of blood cultures, patient age, medical history, interpretation of culture results by the healthcare team and whether infectious diseases consultation was obtained. We also evaluated the susceptibility profiles of a larger collection of GPRs tested in the clinical microbiology laboratory of the Mayo Clinic, Rochester, MN from January 1, 2013, to October 31, 2015. There were a total of 246 GPRs isolated from the blood of 181 patients during the study period. 56% (n = 101) were deemed contaminants by the healthcare team and were not treated; 33% (n = 59) were clinically determined to represent true bacteremia and were treated; and 8% (n = 14) were considered of uncertain significance, with patients prescribed treatment regardless. Patient characteristics associated with an isolate being treated on univariate analysis included younger age (P = 0.02), identification to the species level (P = 0.02), higher number of positive blood culture sets (P < 0.0001), lower time to positivity (P < 0.0001), immunosuppression (P = 0.03), and recommendation made by an infectious disease consultant (P = 0.0005). On multivariable analysis, infectious diseases consultation (P = 0.03), higher number of positive blood culture sets (P = 0.0005) and lower time to positivity (P = 0.03) were associated with an isolate being treated. 100, 83, 48 and 34% of GPRs

  17. Quality of life and psychological morbidity in women with polycystic ovary syndrome: body mass index, age and the provision of patient information are significant modifiers.

    Science.gov (United States)

    Ching, H L; Burke, V; Stuckey, B G A

    2007-03-01

    Polycystic ovary syndrome (PCOS) has clinical features and implications for long-term health that may lead to decreased quality of life (QoL) and psychological morbidity. We studied QoL in women with PCOS, compared the findings with population norms and assessed whether they correlated with reported quality of patient information received. Cross-sectional study. Women with PCOS by National Institutes of Health (NIH) criteria, diagnosis confirmed by one endocrinologist. Four questionnaires were mailed: the Short Form-36 (SF-36), the Quality-of-Life Questionnaire for Women with Polycystic Ovary Syndrome (PCOSQ), the General Health Questionnaire-28 (GHQ-28) and an assessment of information quality and sources, the Patient Information Questionnaire (PIQ). Questionnaires were sent to 443 women with PCOS from one endocrinologist's database; 203 women aged 15-65 years agreed to participate. To compare with Australian population norms, data from those women aged 18-44 years (n = 173) were used. Of these, 64% were obese, 18% overweight and 18% of normal weight. The demographics, socioeconomic status and untreated biochemistry of the responders and the total patient group were not significantly different. SF-36 scores were significantly lower than the age- and sex-matched Australian population (P PCOSQ was similar to other published studies. GHQ-28 identified psychological morbidity in 62.4%, compared with 26.4% in a matched Australian population (P < 0.0001). Body mass index (BMI) was negatively correlated with QoL (P < 0.01). There was a positive association between the psychological domain of QoL and the subjective assessment of the quality of health-related information in general (P < 0.001), for hirsutism (P < 0.01) and for menstrual irregularity (P < 0.05). We have shown impaired QoL and increased prevalence of psychological morbidity in PCOS compared with population norms. The perception of inadequate information about the condition correlated with poorer QoL scores

  18. A Self-consistent Model for a Full Cycle of Recurrent Novae—Wind Mass-loss Rate and X-Ray Luminosity

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Mariko [Department of Astronomy, Keio University, Hiyoshi, Yokohama 223-8521 (Japan); Saio, Hideyuki [Astronomical Institute, Graduate School of Science, Tohoku University, Sendai, 980-8578 (Japan); Hachisu, Izumi, E-mail: mariko.kato@hc.st.keio.ac.jp [Department of Earth Science and Astronomy, College of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902 (Japan)

    2017-04-01

    An unexpectedly slow evolution in the pre-optical-maximum phase was suggested in the very short recurrence period of nova M31N 2008-12a. To obtain reasonable nova light curves we have improved our calculation method by consistently combining optically thick wind solutions of hydrogen-rich envelopes with white dwarf (WD) structures calculated by a Henyey-type evolution code. The wind mass-loss rate is properly determined with high accuracy. We have calculated light curve models for 1.2 M {sub ⊙} and 1.38 M {sub ⊙} WDs with mass accretion rates corresponding to recurrence periods of 10 yr and 1 yr, respectively. The outburst lasts 590/29 days, in which the pre-optical-maximum phase is 82/16 days, for 1.2/1.38 M {sub ⊙}, respectively. Optically thick winds start at the end of the X-ray flash and cease at the beginning of the supersoft X-ray phase. We also present supersoft X-ray light curves including a prompt X-ray flash and later supersoft X-ray phase.

  19. Heavy quark energy loss in nuclear medium

    International Nuclear Information System (INIS)

    Zhang, Benr-Wei; Wang, Enke; Wang, Xin-Nian

    2003-01-01

    Multiple scattering, modified fragmentation functions and radiative energy loss of a heavy quark propagating in a nuclear medium are investigated in perturbative QCD. Because of the quark mass dependence of the gluon formation time, the medium size dependence of heavy quark energy loss is found to change from a linear to a quadratic form when the initial energy and momentum scale are increased relative to the quark mass. The radiative energy loss is also significantly suppressed relative to a light quark due to the suppression of collinear gluon emission by a heavy quark

  20. Induction of IL-6 by Cytotoxic Chemotherapy Is Associated With Loss of Lean Body and Fat Mass in Tumor-free Female Mice.

    Science.gov (United States)

    Elsea, Collin R; Kneiss, Janet A; Wood, Lisa J

    2015-10-01

    Cancer patients treated with cytotoxic chemotherapy experience fatigue and changes in body composition that can impact physical functioning and quality of life during and after treatment. Interleukin-6 (IL-6) is associated with fatigue in cancer survivors and plays an important role in the regulation of body composition. The purpose of the present study was to determine the specific role of IL-6 in cyclophosphamide-doxorubicin-5-fluorouracil (CAF)-induced changes in fatigue, food intake, and body composition using mice lacking IL-6. Female wild-type (WT) and IL-6 (-/-) mice were injected with four cycles of CAF or normal saline (NS) administered at 21-day intervals. Daily voluntary wheel-running activity (VWRA), used as a proxy for fatigue, and food intake were monitored daily up to 21 days after the fourth dose. Dual-energy X-ray absorptiometry (DEXA) was used to assess treatment-related changes in lean body mass (LBM), fat mass (FM), and bone mineral content (BMC). Patterns of change in fatigue and food intake did not differ between CAF-treated WT and IL-6 (-/-) mice. However, a Genotype × Drug interaction was observed for LBM (p = 0.047) and FM (p = 0.035) but not BMC (p = .569). Whereas WT mice lost LBM and FM during CAF treatment, IL-6-deficient mice did not. Treatment-related decreases in levels of the anabolic hormone insulin-like growth factor-1 (IGF-1) may contribute to LBM and FM loss since CAF decreased IGF-1 levels in an IL-6-dependent manner. These findings implicate IL-6 and possibly IGF-1 in the regulation of body composition in breast cancer patients exposed to cytotoxic chemotherapy. © The Author(s) 2014.

  1. Identification and Evaluation of Clinically Significant Nocardia brasiliensis, Nocardia farcinica and Nocardia otitidiscaviarum Strains Using Pyrolysis Mass Spectrometry (PyMS)

    OpenAIRE

    IŞIK, Kamil; KARİPTAŞ, Ergin; ŞAHİN, Nevzat

    2001-01-01

    Out of a total of thirty-nine Nocardia strains, eight species of N. brasiliensis, seventeen species of N. farcinica and fourteen species of N. otitidiscaviarum were identified using Pyrolysis mass spectrometry. N428, N477 N. brasiliensis; N669, N233 N. farcinica; and N231, N232 N. otitidiscaviarum duplicated strains were clustered in their own groups. Strains belonging to Nocardia brasiliensis, Nocardia farcinica and Nocardia otitidiscaviarum formed distinct pyrogroups corresponding to cluste...

  2. Tendency toward Weight Loss among Iranian Adolescent Girls: Study on Perceived Weight, Ideal Body Mass Index and Attitude toward Eating Disorders

    Directory of Open Access Journals (Sweden)

    Malihe Farid

    2016-07-01

    Full Text Available Background Adolescents’ perception of their weight is a strong factor in shaping dietary habits and weight control and management. Among non-overweight and overweight adolescents, both overestimation and underestimation of weight status are associated with harmful effects. This study aimed to examine the relationship between perceived weight and attitude toward eating disorders among adolescent girls living in Karaj, Iran. Materials and Methods Involving a two-stage random sampling, this cross-sectional study was conducted on a total of 537 high school girls 14-18 years of age living in Karaj. The Eating Attitudes Test (EAT-26 was employed to screen for attitude toward eating disorders. Also, anthropometric measurements (weight and height, perceived and the ideal weights of the participants were assessed.  Results The average age of girls participating in the study was 16.12±1.20. According to the results, 70% of girls had normal body mass index. It was found that the ideal weight of 55% of the girls in the normal body mass index group fell under the lower than normal boundary. Moreover, the prevalence of eating disorders was estimated to be 23.6%. The attitude toward eating disorder was significantly correlated with body mass index of participants and their self-concept (P

  3. Integrative Analyses of miRNA-mRNA Interactions Reveal let-7b, miR-128 and MAPK Pathway Involvement in Muscle Mass Loss in Sex-Linked Dwarf Chickens

    Science.gov (United States)

    Luo, Wen; Lin, Shumao; Li, Guihuan; Nie, Qinghua; Zhang, Xiquan

    2016-01-01

    The sex-linked dwarf (SLD) chicken is an ideal model system for understanding growth hormone (GH)-action and growth hormone receptor (GHR) function because of its recessive mutation in the GHR gene. Skeletal muscle mass is reduced in the SLD chicken with a smaller muscle fiber diameter. Our previous study has presented the mRNA and miRNA expression profiles of the SLD chicken and normal chicken between embryo day 14 and seven weeks of age. However, the molecular mechanism of GHR-deficient induced muscle mass loss is still unclear, and the key molecules and pathways underlying the GHR-deficient induced muscle mass loss also remain to be illustrated. Here, by functional network analysis of the differentially expressed miRNAs and mRNAs between the SLD and normal chickens, we revealed that let-7b, miR-128 and the MAPK pathway might play key roles in the GHR-deficient induced muscle mass loss, and that the reduced cell division and growth are potential cellular processes during the SLD chicken skeletal muscle development. Additionally, we also found some genes and miRNAs involved in chicken skeletal muscle development, through the MAPK, PI3K-Akt, Wnt and Insulin signaling pathways. This study provides new insights into the molecular mechanism underlying muscle mass loss in the SLD chickens, and some regulatory networks that are crucial for chicken skeletal muscle development. PMID:26927061

  4. A Closer Earth and the Faint Young Sun Paradox: Modification of the Laws of Gravitation or Sun/Earth Mass Losses?

    Directory of Open Access Journals (Sweden)

    Lorenzo Iorio

    2013-10-01

    Full Text Available Given a solar luminosity LAr = 0.75L0 at the beginning of the Archean 3.8 Ga ago, where L0 is the present-day one, if the heliocentric distance, r, of the Earth was rAr = 0.956r0, the solar irradiance would have been as large as IAr = 0.82I0. It would have allowed for a liquid ocean on the terrestrial surface, which, otherwise, would have been frozen, contrary to the empirical evidence. By further assuming that some physical mechanism subsequently displaced the Earth towards its current distance in such a way that the irradiance stayed substantially constant over the entire Archean from 3.8 to 2.5 Ga ago, a relative recession per year as large as r˙/r ≈3.4 × 10−11 a−1 would have been required. Although such a figure is roughly of the same order of magnitude of the value of the Hubble parameter 3.8 Ga ago HAr = 1.192H0 = 8.2 × 10−11 a−1, standard general relativity rules out cosmological explanations for the hypothesized Earth’s recession rate. Instead, a class of modified theories of gravitation with nonminimal coupling between the matter and the metric naturally predicts a secular variation of the relative distance of a localized two-body system, thus yielding a potentially viable candidate to explain the putative recession of the Earth’s orbit. Another competing mechanism of classical origin that could, in principle, allow for the desired effect is the mass loss, which either the Sun or the Earth itself may have experienced during the Archean. On the one hand, this implies that our planet should have lost 2% of its present mass in the form of eroded/evaporated hydrosphere. On the other hand, it is widely believed that the Sun could have lost mass at an enhanced rate, due to a stronger solar wind in the past for not more than ≈ 0.2–0.3 Ga.

  5. Normal protein intake is required for body weight loss and weight maintenance, and elevated protein intake for additional preservation of resting energy expenditure and fat free mass.

    Science.gov (United States)

    Soenen, Stijn; Martens, Eveline A P; Hochstenbach-Waelen, Ananda; Lemmens, Sofie G T; Westerterp-Plantenga, Margriet S

    2013-05-01

    Energy-restricted high-protein diets (HPDs) have shown favorable results for body weight (BW) management, yet studies differ in their outcomes depending on the dietary protein content. Our objective was to determine the effects of dietary protein content on BW loss-related variables during a 6-mo energy restriction with the use of diets containing protein at the level of requirement [normal-protein diet (NPD), 0.8 g · kg BW(-1) (.) d(-1)] and above (HPD, 1.2 g · kg BW(-1) (.) d(-1)). In overweight and obese participants (24 men and 48 women), BW, body composition, and metabolic responses were assessed before and after subsequent energy intakes of 100, 33, and 67% of the original individual daily energy requirements. Protein intake was consistent in the NPD (0.8 ± 0.3 g · kg BW(-1) (.) d(-1)) and HPD (1.2 ± 0.3 g · kg BW(-1) (.) d(-1)) groups throughout the study (P body fat mass similarly decreased in the NPD and HPD groups (P initial sparing effect of FFM and lowering of DBP.

  6. A 12-week treatment with the long-acting glucagon-like peptide 1 receptor agonist liraglutide leads to significant weight loss in a subset of obese women with newly diagnosed polycystic ovary syndrome.

    Science.gov (United States)

    Jensterle, Mojca; Kravos, Nika Aleksandra; Pfeifer, Marija; Kocjan, Tomaz; Janez, Andrej

    2015-01-01

    The long-acting glucagon-like peptide 1 receptor agonist liraglutide is linked to progressive and sustained weight loss in obese people with diabetes. However, its efficacy and safety in women with polycystic ovary syndrome (PCOS) has not yet been addressed. Thirty-two obese women (aged 27.6±7.2 years, BMI 39.5±6.2 kg/m(2)) with newly diagnosed PCOS were randomized to receive either liraglutide 1.2 mg QD sc (n=17) or metformin 1000 mg BID po (n=15) for 12 weeks; 28 patients completed the study (14 on liraglutide and 14 on metformin). The main outcome was change in body weight. Intention-to-treat analysis showed significant BMI (-0.98 kg/m(2); pweight (-2.52 kg; p2), severe obesity and higher odds ratio for the metabolic syndrome (OR=3.9), the patients fared much better with liraglutide than with metformin (mean BMI decreased 2.13 kg/m(2) vs. 0.62 kg/m(2), respectively). Short-term liraglutide treatment was associated with significant weight loss in a subset of obese patients with newly diagnosed PCOS and a higher metabolic risk profile.

  7. Character, mass, distribution, and origin of tephra-fall deposits from the 2009 eruption of Redoubt Volcano, Alaska: highlighting the significance of particle aggregation

    Science.gov (United States)

    Wallace, Kristi; Coombs, Michelle L; Schaefer, Janet R.

    2013-01-01

    The 2009 eruption of Redoubt Volcano included 20 tephra-producing explosions between March 15, 2009 and April 4, 2009 (UTC). Next-Generation radar (NEXRAD) data show that plumes reached heights between 4.6 km and 19 km asl and were distributed downwind along nearly all azimuths of the volcano. Explosions lasted between 0.8 mm thick), including communities along the Kenai Peninsula (80–100 km) and the city of Anchorage (170 km). Trace ash (mass of tephra-fall deposits at 54.6 × 109 kg with a total DRE volume of 20.6 × 106 m3.

  8. A novel Dual Amylin and Calcitonin Receptor Agonist (DACRA), KBP-089, induces weight loss through a reduction in fat, but not lean mass, while improving food preference

    DEFF Research Database (Denmark)

    Gydesen, Sofie; Hjuler, Sara Toftegaard; Freving, Zenia

    2017-01-01

    Background and Purpose Obesity and associated co-morbidities, such as type 2 diabetes and non-alcoholic fatty liver disease, are major health challenges – hence, development of weight loss therapies with the ability to reduce the co-morbidities is key. Experimental Approach The effect of the dual...... amylin and calcitonin receptor agonist (DACRA), KBP-089, on bodyweight, glucose homeostasis, and fatty acid accumulation in liver and muscle tissue, food preference was investigated. Further, we elucidate weight-independent effects of KBP-089 using a weight-matched group. Key Results High fat diet fed...... improved glucose homeostasis through improved insulin action. To obtain a weight-matched group, significantly less food was offered (9% less than in the KBP-089 group). Weight-matching led to improved glucose homeostasis through lowered plasma insulin; however, these were inferior to the effect of KBP-089...

  9. Indicators of clinical significance among women in the community with binge-eating disorder symptoms: Delineating the roles of binge frequency, body mass index, and overvaluation.

    Science.gov (United States)

    Mitchison, Deborah; Rieger, Elizabeth; Harrison, Carmel; Murray, Stuart B; Griffiths, Scott; Mond, Jonathan

    2018-02-01

    This study aimed to investigate the relative contributions of binge eating, body image disturbance, and body mass index (BMI) to distress and disability in binge-eating disorder (BED). A community sample of 174 women with BED-type symptomatology provided demographic, weight, and height information, and completed measures of overvaluation of weight/shape and binge eating, general psychological distress and impairment in role functioning. Correlation and regression analyses examined the associations between predictors (binge eating, overvaluation, BMI), and outcomes (distress, functional impairment). Binge eating and overvaluation were moderately to strongly correlated with distress and functional impairment, whereas BMI was not correlated with distress and only weakly correlated with functional impairment. Regression analysis indicated that both overvaluation and binge eating were strong and unique predictors of both distress and impairment, the contribution of overvaluation to variance in functional impairment being particularly strong, whereas BMI did not uniquely predict functional impairment or distress. The findings support the inclusion of overvaluation as a diagnostic criterion or specifier in BED and the need to focus on body image disturbance in treatment and public health efforts in order to reduce the individual and community health burden of this condition. © 2017 Wiley Periodicals, Inc.

  10. Greenland and Antarctica Ice Sheet Mass Changes and Effects on Global Sea Level

    DEFF Research Database (Denmark)

    Forsberg, René; Sørensen, Louise Sandberg; Simonsen, Sebastian Bjerregaard

    2017-01-01

    Thirteen years of GRACE data provide an excellent picture of the current mass changes of Greenland and Antarctica, with mass loss in the GRACE period 2002–2015 amounting to 265 ± 25 GT/year for Greenland (including peripheral ice caps), and 95 ± 50 GT/year for Antarctica, corresponding to 0.......72 and 0.26 mm/year average global sea level change. A significant acceleration in mass loss rate is found, especially for Antarctica, while Greenland mass loss, after a corresponding acceleration period, and a record mass loss in the summer of 2012, has seen a slight decrease in short-term mass loss trend....... The yearly mass balance estimates, based on point mass inversion methods, have relatively large errors, both due to uncertainties in the glacial isostatic adjustment processes, especially for Antarctica, leakage from unmodelled ocean mass changes, and (for Greenland) difficulties in separating mass signals...

  11. Projected economic losses due to vector and vector-borne parasitic diseases in livestock of India and its significance in implementing the concept of integrated practices for vector management

    Directory of Open Access Journals (Sweden)

    B. W. Narladkar

    2018-02-01

    Full Text Available Broadly, species of arthropods infesting livestock are grouped into flies (biting and non-biting, fleas, lice (biting and sucking, ticks (soft and hard, and mites (burrowing, non-burrowing, and follicular. Among which, biting and non-biting flies and ticks are the potent vectors for many bacterial, viral, rickettsial, and protozoan diseases. Vectors of livestock are having economic significance on three points (1 direct losses from their bite and annoyance, worries, and psychological disturbances produced during the act of biting and feeding, (2 diseases they transmit, and (3 expenditure incurred for their control. Flies such as Culicoides spp. and Musca spp. and various species of hard ticks play important role in disease transmission in addition to their direct effects. For control of vectors, recent concept of integrated pest management (IPM provides the best solution and also addresses the problems related to acaricide resistance and environmental protection from hazardous chemicals. However, to successfully implement the concept of IPM, for each vector species, estimation of two monitory benchmarks, i.e., economic injury level (EIL and economic threshold level (ETL is essential prerequisite. For many vector species and under several circumstances, estimation of EIL and ETL appears to be difficult. Under such scenario, although may not be exact, an approximate estimate can be accrued by taking into account several criteria such as percent prevalence of vectors in a geographical area, percent losses produced, total livestock population, and current prices of livestock products such as milk, meat, and wool. Method for approximate estimation is first time described and elaborated in the present review article.

  12. Projected economic losses due to vector and vector-borne parasitic diseases in livestock of India and its significance in implementing the concept of integrated practices for vector management

    Science.gov (United States)

    Narladkar, B. W.

    2018-01-01

    Broadly, species of arthropods infesting livestock are grouped into flies (biting and non-biting), fleas, lice (biting and sucking), ticks (soft and hard), and mites (burrowing, non-burrowing, and follicular). Among which, biting and non-biting flies and ticks are the potent vectors for many bacterial, viral, rickettsial, and protozoan diseases. Vectors of livestock are having economic significance on three points (1) direct losses from their bite and annoyance, worries, and psychological disturbances produced during the act of biting and feeding, (2) diseases they transmit, and (3) expenditure incurred for their control. Flies such as Culicoides spp. and Musca spp. and various species of hard ticks play important role in disease transmission in addition to their direct effects. For control of vectors, recent concept of integrated pest management (IPM) provides the best solution and also addresses the problems related to acaricide resistance and environmental protection from hazardous chemicals. However, to successfully implement the concept of IPM, for each vector species, estimation of two monitory benchmarks, i.e., economic injury level (EIL) and economic threshold level (ETL) is essential prerequisite. For many vector species and under several circumstances, estimation of EIL and ETL appears to be difficult. Under such scenario, although may not be exact, an approximate estimate can be accrued by taking into account several criteria such as percent prevalence of vectors in a geographical area, percent losses produced, total livestock population, and current prices of livestock products such as milk, meat, and wool. Method for approximate estimation is first time described and elaborated in the present review article. PMID:29657396

  13. Mass loss controlled thermal pretreatment system to assess the effects of pretreatment temperature on organic matter solubilization and methane yield from food waste.

    Directory of Open Access Journals (Sweden)

    Martha Minale Yeshanew

    2016-09-01

    Full Text Available The effects of thermal pretreatment (TP on the main characteristics of food waste (FW and its biochemical methane potential (BMP and distribution of volatile fatty acids (VFAs under mesophilic condition (35 ⁰C were investigated. The TP experiments were carried out at 80 °C, 100 °C, 120 °C for 2 hour and 140 °C for 1 hour. The designed TP set-up was able to minimize the organic matter loss during the course of the pretreatments. Soluble organic fractions evaluated in terms of chemical oxygen demand (COD and soluble protein increased linearly with pretreatment temperature. In contrast, the carbohydrate solubilization was more enhanced (30 % higher solubilization by the TP at lower temperature (80 °C. A slight increment of soluble phenols was found, particularly for temperatures exceeding 100 °C. Thermally pretreated FW under all conditions exhibited an improved methane yield than the untreated FW, due to the increased organic matter solubilization. The highest cumulative methane yield of 442 (± 8.6 mL/gVSadded, corresponding to a 28.1 % enhancement compared to the untreated FW, was obtained with a TP at 80 °C. No significant variation in the VFAs trends were observed during the BMP tests under all investigated conditions.

  14. Hearing loss

    Science.gov (United States)

    Decreased hearing; Deafness; Loss of hearing; Conductive hearing loss; Sensorineural hearing loss; Presbycusis ... Symptoms of hearing loss may include: Certain sounds seeming too loud Difficulty following conversations when two or more people are talking ...

  15. Nutrient-rich dairy proteins improve appendicular skeletal muscle mass and physical performance, and attenuate the loss of muscle strength in older men and women subjects: a single-blind randomized clinical trial

    Directory of Open Access Journals (Sweden)

    Alemán-Mateo H

    2014-09-01

    Full Text Available Heliodoro Alemán-Mateo,1 Virginia Ramírez Carreón,1 Liliana Macías,1 Humberto Astiazaran-García,1 Ana Cristina Gallegos-Aguilar,1 José Rogelio Ramos Enríquez2 1Coordinación de Nutrición, Centro de Investigación en Alimentación y Desarrollo, A.C., 2Laboratorio de Análisis Clínicos e Investigación, Departamento de Ciencias Químico Biológicas, Universidad de Sonora, Hermosillo, Mexico Background: At present, it is unknown whether the use of nutrient-rich dairy proteins improves the markers of sarcopenia syndrome. Therefore, our proposal was to investigate whether ­adding 210 g of ricotta cheese daily would improve skeletal muscle mass, handgrip strength, and ­physical performance in non-sarcopenic older subjects.Subjects and methods: This was a single-blind randomized clinical trial that included two homogeneous, randomized groups of men and women over 60 years of age. Participants in the intervention group were asked to consume their habitual diet but add 210 g of ricotta cheese (IG/HD + RCH, while the control group was instructed to consume only their habitual diet (CG/HD. Basal and 12-week follow-up measurements included appendicular skeletal muscle mass (ASMM by dual-energy X-ray absorptiometry, handgrip strength by a handheld dynamometer, and physical performance using the short physical performance battery (SPPB and the stair-climb power test (SCPT. The main outcomes were relative changes in ASMM, strength, SPPB, and SCPT.Results: ASMM increased in the IG/HD + RCH (0.6±3.5 kg, but decreased in the CG/HD (–1.0±2.6. The relative change between groups was statistically significant (P=0.009. The relative change in strength in both groups was negative, but the loss of muscle strength was more pronounced in CG/HD, though in this regard statistical analysis found only a tendency (P=0.07. The relative change in the balance-test scores was positive for the IG/HD + RCH, while in the CG/HD it was negative, as those individuals had

  16. Pregnancy Loss

    Science.gov (United States)

    ... To receive Pregnancy email updates Enter email Submit Pregnancy loss Pregnancy loss is a harsh reality faced ... have successful pregnancies. Expand all | Collapse all Why pregnancy loss happens As many as 10 to 15 ...

  17. Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice

    NARCIS (Netherlands)

    Ellenbroek, Johanne H; van Dijck, Laura; Töns, Hendrica A; Rabelink, Ton J; Carlotti, Françoise; Ballieux, Bart E P B; de Koning, Eelco J P

    2014-01-01

    High-fat, low-carbohydrate ketogenic diets (KD) are used for weight loss and for treatment of refractory epilepsy. Recently, short-time studies in rodents have shown that, besides their beneficial effect on body weight, KD lead to glucose intolerance and insulin resistance. However, the long-term

  18. Geodetic measurements reveal similarities between post–Last Glacial Maximum and present-day mass loss from the Greenland ice sheet

    DEFF Research Database (Denmark)

    Khan, Shfaqat Abbas; Sasgen, Ingo; Bevis, Michael

    2016-01-01

    and ocean load changes occurring since the Last Glacial Maximum (LGM; ~21 thousand years ago) and may be used to constrain the GrIS deglaciation history. We use data from the Greenland Global Positioning System network to directly measure GIA and estimate basinwide mass changes since the LGM. Unpredicted......Accurate quantification of the millennial-scale mass balance of the Greenland ice sheet (GrIS) and its contribution to global sea-level rise remain challenging because of sparse in situ observations in key regions. Glacial isostatic adjustment (GIA) is the ongoing response of the solid Earth to ice...

  19. The Effect of Adherence to Dietary Tracking on Weight Loss: Using HLM to Model Weight Loss over Time.

    Science.gov (United States)

    Ingels, John Spencer; Misra, Ranjita; Stewart, Jonathan; Lucke-Wold, Brandon; Shawley-Brzoska, Samantha

    2017-01-01

    The role of dietary tracking on weight loss remains unexplored despite being part of multiple diabetes and weight management programs. Hence, participants of the Diabetes Prevention and Management (DPM) program (12 months, 22 sessions) tracked their food intake for the duration of the study. A scatterplot of days tracked versus total weight loss revealed a nonlinear relationship. Hence, the number of possible tracking days was divided to create the 3 groups of participants: rare trackers (66% total days tracked). After controlling for initial body mass index, hemoglobin A 1c , and gender, only consistent trackers had significant weight loss (-9.99 pounds), following a linear relationship with consistent loss throughout the year. In addition, the weight loss trend for the rare and inconsistent trackers followed a nonlinear path, with the holidays slowing weight loss and the onset of summer increasing weight loss. These results show the importance of frequent dietary tracking for consistent long-term weight loss success.

  20. Geodetic measurements reveal similarities between post–Last Glacial Maximum and present-day mass loss from the Greenland ice sheet

    DEFF Research Database (Denmark)

    Khan, Shfaqat A.; Sasgen, Ingo; Bevis, Michael

    2016-01-01

    Accurate quantification of the millennial-scale mass balance of the Greenland ice sheet (GrIS) and its contribution to global sea-level rise remain challenging because of sparse in situ observations in key regions. Glacial isostatic adjustment (GIA) is the ongoing response of the solid Earth to ice...

  1. Factorial structure of complicated grief: associations with loss-related traumatic events and psychosocial impacts of mass conflict amongst West Papuan refugees.

    Science.gov (United States)

    Tay, Alvin Kuowei; Rees, Susan; Chen, Jack; Kareth, Moses; Silove, Derrick

    2016-03-01

    Definitions of complicated grief vary across diagnostic systems, being represented as persistent complex bereavement (PCB) in DSM-5 and prolonged grief disorder (PGD) in the proposed revision of the ICD system. A past study in a high-income country has identified a six-factor structure for complicated grief, but there are no data testing this or any other model across cultures. The present study reports findings from a survey amongst West Papuan refugees (n = 230, response rate = 92 %) residing in Port Moresby, Papua New Guinea. We applied culturally adapted measures of conflict-related traumatic event (TEs) (drawing specifically on domains of conflict and loss), symptoms of complicated grief adapted and modified to the culture, and a multidimensional psychosocial index of the broader effects of conflict and displacement. Confirmatory factor analysis yielded a single higher order construct of complicated grief comprising six factors of yearning/preoccupation; shock/disbelief; anger/negative appraisal; behavioural change; estrangement from others/impairment; and a novel dimension of confusion/diminished identity. In contrast, our analysis failed to support DSM or ICD models of PCB or PGD. A Multiple Indicators Multiple Causes (MIMIC) model revealed that traumatic loss and the sense of injustice each were associated with the unitary construct of complicated grief and its subdomains of yearning/preoccupation; shock/disbelief; anger/negative appraisal (exclusive to injustice); and estrangement from others/social impairment (exclusive to TE domain of conflict and loss). Conflict and loss associated with feelings of injustice may be especially pathogenic in generating the anger/negative appraisal component of complicated grief amongst refugees.

  2. Study on mass-inertia characteristics of human body segments by gamma-scanning during 6-month hypokinesia

    International Nuclear Information System (INIS)

    Tishler, V.A.; Zatsiorskij, V.M.; Seluyanov, V.N.

    1981-01-01

    It was found that there was a distinct redistribution of body masses in 18 test subjects exposed to 6-month hypokinesia. Six of them (who did not exercise) showed losses of muscle mass (primarily antigravity muscles) and gain of adipose mass, and 12 test subjects (who exercised as a countermeasure against hypokinetic effects) displayed insignificant losses of muscle mass and significant gain of adipose mass [ru

  3. Posttraumatic Stress Disorder, obesity, and weight loss

    DEFF Research Database (Denmark)

    Johannessen, Kim Berg; Berntsen, Dorthe

    Posttraumatic Stress Disorder (PTSD) has frequently been found to have an impact on the development of obesity, with the relationship between past traumatic episodes and obesity usually thought of as uni-directional. The purpose of the present study was to examine whether the level of PTSD......-symptoms would decrease as a result of weight loss in obese participants during a 16 week stay at a weight loss facility. During the 16 weeks participants’ Body Mass Index (BMI) decreased significantly. Concurrently, a significant decline in the level of PTSD symptoms was also reported. During the first week...

  4. THE EFFECTS OF SPRAY-CHILLING ASSOCIATED TO CONVENTIONAL CHILLING ON MASS LOSS, BACTERIOLOGYCAL AND PHYSICO-CHEMICAL QUALITY OF BEEF CARCASS

    Directory of Open Access Journals (Sweden)

    Moacir Evandro Lage

    2006-10-01

    Full Text Available The purpose of this study was to verify the effect of conventional air chilling associated to intermittent spray-chilling treatment, on weight loss, physico-chemical and bacteriological quality of beef carcasses. Two plants of commercial beef slaughterhouse located in Goiânia and fiscalized by the Federal Inspection Service were used to develop the research. The spray-chilling treatment was accomplished in an intermittent way, commanded by acontrolled logical program, with cycles of 90 seconds, in intervals of 30 minutes, during the first 4 hours of the chilling process. Physico-chemical and bacteriological analysis were made in spray-chilled water and carcasses samples, according to recommendation of the effective legislation.The average values of carcasses weight loss of treatment group were lower to the ones verified for the control group,in both plants, A and B, (P < 0,001, showing a high economic potential. As a conclusion of physico-chemical and bacteriological analysis results of water and meat samples, it is clear that the technology of chilling beef carcasses inthe conventional system associated to spraying did not interfere in the quality of meat, and it can become an analysis object on part of official organs for sanitary regulation and fiscalization, for its definitive adoption. KEY WORDS: Spray-chilling, shrinkage, beef carcass.

  5. Atmosphere Impact Losses

    Science.gov (United States)

    Schlichting, Hilke E.; Mukhopadhyay, Sujoy

    2018-02-01

    Determining the origin of volatiles on terrestrial planets and quantifying atmospheric loss during planet formation is crucial for understanding the history and evolution of planetary atmospheres. Using geochemical observations of noble gases and major volatiles we determine what the present day inventory of volatiles tells us about the sources, the accretion process and the early differentiation of the Earth. We further quantify the key volatile loss mechanisms and the atmospheric loss history during Earth's formation. Volatiles were accreted throughout the Earth's formation, but Earth's early accretion history was volatile poor. Although nebular Ne and possible H in the deep mantle might be a fingerprint of this early accretion, most of the mantle does not remember this signature implying that volatile loss occurred during accretion. Present day geochemistry of volatiles shows no evidence of hydrodynamic escape as the isotopic compositions of most volatiles are chondritic. This suggests that atmospheric loss generated by impacts played a major role during Earth's formation. While many of the volatiles have chondritic isotopic ratios, their relative abundances are certainly not chondritic again suggesting volatile loss tied to impacts. Geochemical evidence of atmospheric loss comes from the {}3He/{}^{22}Ne, halogen ratios (e.g., F/Cl) and low H/N ratios. In addition, the geochemical ratios indicate that most of the water could have been delivered prior to the Moon forming impact and that the Moon forming impact did not drive off the ocean. Given the importance of impacts in determining the volatile budget of the Earth we examine the contributions to atmospheric loss from both small and large impacts. We find that atmospheric mass loss due to impacts can be characterized into three different regimes: 1) Giant Impacts, that create a strong shock transversing the whole planet and that can lead to atmospheric loss globally. 2) Large enough impactors (m_{cap} ≳ √{2

  6. Recurrent pregnancy loss

    DEFF Research Database (Denmark)

    Egerup, P; Kolte, A M; Larsen, E C

    2016-01-01

    STUDY QUESTION: Is there a different prognostic impact for consecutive and non-consecutive early pregnancy losses in women with secondary recurrent pregnancy loss (RPL)? SUMMARY ANSWER: Only consecutive early pregnancy losses after the last birth have a statistically significant negative prognostic...... impact in women with secondary RPL. WHAT IS KNOWN ALREADY: The risk of a new pregnancy loss increases with the number of previous pregnancy losses in patients with RPL. Second trimester losses seem to exhibit a stronger negative impact than early losses. It is unknown whether the sequence of pregnancy...... losses plays a role for the prognosis in patients with a prior birth. STUDY DESIGN, SIZE, DURATION: This retrospective cohort study of pregnancy outcome in patients with unexplained secondary RPL included in three previously published, Danish double-blinded placebo-controlled trials of intravenous...

  7. Application of ultra-high-performance liquid chromatography coupled with LTQ-Orbitrap mass spectrometry for identification, confirmation and quantitation of illegal adulterated weight-loss drugs in plant dietary supplements.

    Science.gov (United States)

    Cheng, Qiaoyuan; Shou, Linjun; Chen, Cen; Shi, Shi; Zhou, Minghao

    2017-10-01

    In this paper, an ultra-high-performance liquid chromatography coupled with linear ion trap quadrupole Orbitrap high resolution mass spectrometry (UHPLC-LTQ-Orbitrap HRMS) method was developed and validated for identification, confirmation and quantitation of illegal adulterated weight-loss drugs in plant dietary supplements. 13 wt-loss drugs were well separated by the gradient elution of 10mmol/L ammonium acetate - 0.05% formic acid H 2 O and acetonitrile at a flow rate of 0.2mL/min within 12min. The MS analysis was operated under the positive ion and in full MS/dd-MS 2 (data-dependent MS 2 ) mode. The full MS scan with resolution at 60 000 FWHM and narrow mass windows at 5ppm acquired data for identification and quantitation, and dd-MS 2 scan with resolution at 15 000 FWHM obtained product ions for confirmation. The method validation showed good linearity with coefficients of determination (r 2 ) higher than 0.9951 for all analytes. Meantime, all the LOD and LLOQ values were in the respective range of 0.3-2 and 1-9ng/g. The accuracy, intra- and inter-day precision were in the ranges of -1.7 to 3.4%, 1.7-5.0% and 1.9-4.4%, respectively. The mean recoveries ranged from 85.4 to 107.1%, while the absolute and relative matrix effect were in the corresponding range of 98.2-108.6% and 2.6-8.7%. Among 120 batches of weight loss plant dietary supplements, sibutramine and fluoxertine or both were positive in 29 samples. In general, LTQ-Orbitrap HRMS technology was a powerful tool for the analysis of illegal ingredients in dietary supplements. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Loss and benefit of DR system in mass screening for upper GI-tracts. Comparison with an II-TV based DR system and 100-mm roll-film system

    International Nuclear Information System (INIS)

    Ogura, Toshihiro; Fujita, Hiroshi.

    1995-01-01

    A 2048 x 2048 matrix II-TV based digital radiography (DR) system, a fully digital imaging system with diagnosis on the CRT monitor, had been introduced to Cancer Institute Hospital for the GI-tracts examinations since January 1990. Furthermore, we had applied it to the mass screening of upper GI-tract since November 1992. In the present study, a retrospective study on clinical evaluation and features of the DR system for the mass screening were investigated and compared with the screening data taken by conventional 100-mm roll-film technique in the previous year. The loss ratios and appearance of the mucosal patterns in upper gastric images were studied as well. Also determined was the reading time of those images in the mass screening situation. It was found that the loss ratio on the subject image information in 100-mm roll-film images was smaller than that in DR images. However, the DR images processed by windowing technique provided the perfect information without partially over or under density area. It was shown that the clinical image quality greatly depended on the radiographic technique by radiologists or technologists rather than on the imaging modality itself employed; even in II/TV-DR system, the radiographic technique is important. Because of some issues, including the size of CRT monitor, eyestrain for CRT monitor, and windowing operation regard to reading system, the reading time of CRT images was 1.44-2.05 times longer than that of 100-mm roll-film images. (author)

  9. Greenland Ice Sheet Mass Balance

    Science.gov (United States)

    Reeh, N.

    1984-01-01

    Mass balance equation for glaciers; areal distribution and ice volumes; estimates of actual mass balance; loss by calving of icebergs; hydrological budget for Greenland; and temporal variations of Greenland mass balance are examined.

  10. Structure and evolution of the drainage system of a Himalayan debris-covered glacier, and its relationship with patterns of mass loss

    Directory of Open Access Journals (Sweden)

    D. I. Benn

    2017-09-01

    Full Text Available We provide the first synoptic view of the drainage system of a Himalayan debris-covered glacier and its evolution through time, based on speleological exploration and satellite image analysis of Ngozumpa Glacier, Nepal. The drainage system has several linked components: (1 a seasonal subglacial drainage system below the upper ablation zone; (2 supraglacial channels, allowing efficient meltwater transport across parts of the upper ablation zone; (3 sub-marginal channels, allowing long-distance transport of meltwater; (4 perched ponds, which intermittently store meltwater prior to evacuation via the englacial drainage system; (5 englacial cut-and-closure conduits, which may undergo repeated cycles of abandonment and reactivation; and (6 a "base-level" lake system (Spillway Lake dammed behind the terminal moraine. The distribution and relative importance of these elements has evolved through time, in response to sustained negative mass balance. The area occupied by perched ponds has expanded upglacier at the expense of supraglacial channels, and Spillway Lake has grown as more of the glacier surface ablates to base level. Subsurface processes play a governing role in creating, maintaining, and shutting down exposures of ice at the glacier surface, with a major impact on spatial patterns and rates of surface mass loss. Comparison of our results with observations on other glaciers indicate that englacial drainage systems play a key role in the response of debris-covered glaciers to sustained periods of negative mass balance.

  11. Experiencing Loss

    DEFF Research Database (Denmark)

    Kristiansen, Maria; Younis, Tarek; Hassani, Amani

    2015-01-01

    In this article, we explore how Islam, minority status and refugee experiencesintersect in shaping meaning-making processes following bereavement. We do this througha phenomenological analysis of a biographical account of personal loss told by Aisha, a Muslim Palestinian refugee living in Denmark......, who narrates her experience of losing herhusband to lung cancer. By drawing on a religious framework, Aisha creates meaning fromher loss, which enables her to incorporate this loss into her life history and sustain agency.Her narrative invites wider audiences to witness her tale of overcoming loss...

  12. Memory loss

    Science.gov (United States)

    ... barbiturates or ( hypnotics ) ECT (electroconvulsive therapy) (most often short-term memory loss) Epilepsy that is not well controlled Illness that ... appointment. Medical history questions may include: Type of memory loss, such as short-term or long-term Time pattern, such as how ...

  13. THE MASS-LOSS RETURN FROM EVOLVED STARS TO THE LARGE MAGELLANIC CLOUD. IV. CONSTRUCTION AND VALIDATION OF A GRID OF MODELS FOR OXYGEN-RICH AGB STARS, RED SUPERGIANTS, AND EXTREME AGB STARS

    International Nuclear Information System (INIS)

    Sargent, Benjamin A.; Meixner, M.; Srinivasan, S.

    2011-01-01

    To measure the mass loss from dusty oxygen-rich (O-rich) evolved stars in the Large Magellanic Cloud (LMC), we have constructed a grid of models of spherically symmetric dust shells around stars with constant mass-loss rates using 2Dust. These models will constitute the O-rich model part of the 'Grid of Red supergiant and Asymptotic giant branch star ModelS' (GRAMS). This model grid explores four parameters-stellar effective temperature from 2100 K to 4700 K; luminosity from 10 3 to 10 6 L sun ; dust shell inner radii of 3, 7, 11, and 15 R star ; and 10.0 μm optical depth from 10 -4 to 26. From an initial grid of ∼1200 2Dust models, we create a larger grid of ∼69,000 models by scaling to cover the luminosity range required by the data. These models are available online to the public. The matching in color-magnitude diagrams and color-color diagrams to observed O-rich asymptotic giant branch (AGB) and red supergiant (RSG) candidate stars from the SAGE and SAGE-Spec LMC samples and a small sample of OH/IR stars is generally very good. The extreme AGB star candidates from SAGE are more consistent with carbon-rich (C-rich) than O-rich dust composition. Our model grid suggests lower limits to the mid-infrared colors of the dustiest AGB stars for which the chemistry could be O-rich. Finally, the fitting of GRAMS models to spectral energy distributions of sources fit by other studies provides additional verification of our grid and anticipates future, more expansive efforts.

  14. Hereditary Hearing Loss.

    Science.gov (United States)

    Tran, LenhAnh P.; Grundfast, Kenneth M.

    1997-01-01

    This article discusses inheritance patterns in hearing loss, epidemiology, clues to genetic causes, locating genes that cause hereditary disorders, genes related to hearing loss disorders in individuals with Usher syndrome, Waardenburg syndrome, Treacher-Collins syndrome, Branchio-oto-renal and Pendred syndromes, and the significance of finding…

  15. Cutaneous water loss and sphingolipids in the stratum corneum of house sparrows, Passer domesticus L., from desert and mesic environments as determined by reversed phase high-performance liquid chromatography coupled with atmospheric pressure photospray ionization mass spectrometry.

    Science.gov (United States)

    Muñoz-Garcia, Agustí; Ro, Jennifer; Brown, Johnie C; Williams, Joseph B

    2008-02-01

    Because cutaneous water loss (CWL) represents half of total water loss in birds, selection to reduce CWL may be strong in desert birds. We previously found that CWL of house sparrows from a desert population was about 25% lower than that of individuals from a mesic environment. The stratum corneum (SC), the outer layer of the epidermis, serves as the primary barrier to water vapor diffusion through the skin. The avian SC is formed by layers of corneocytes embedded in a lipid matrix consisting of cholesterol, free fatty acids and two classes of sphingolipids, ceramides and cerebrosides. The SC of birds also serves a thermoregulatory function; high rates of CWL keep body temperatures under lethal limits in episodes of heat stress. In this study, we used high-performance liquid chromatography coupled with atmospheric pressure photoionization-mass spectrometry (HPLC/APPI-MS) to identify and quantify over 200 sphingolipids in the SC of house sparrows from desert and mesic populations. Principal components analysis (PCA) led to the hypotheses that sphingolipids in the SC of desert sparrows have longer carbon chains in the fatty acid moiety and are more polar than those found in mesic sparrows. We also tested the association between principal components and CWL in both populations. Our study suggested that a reduction in CWL found in desert sparrows was, in part, the result of modifications in chain length and polarity of the sphingolipids, changes that apparently determine the interactions of the lipid molecules within the SC.

  16. DECOVALEX III/BENCHPAR PROJECTS. Approaches to Upscaling Thermal-Hydro-Mechanical Processes in a Fractured Rock. Mass and its Significance for Large-Scale Repository Performance Assessment. Summary of Findings. Report of BMT2/WP3

    International Nuclear Information System (INIS)

    Andersson, Johan; Staub, Isabelle; Knight, Les

    2005-02-01

    The Benchmark Test 2 of DECOVALEX III and Work Package 3 of BENCHPAR concerns the upscaling Thermal (T), Hydrological (H) and Mechanical (M) processes in a fractured rock mass and its significance for large-scale repository performance assessment. The work is primarily concerned with the extent to which various thermo-hydro-mechanical couplings in a fractured rock mass adjacent to a repository are significant in terms of solute transport typically calculated in large-scale repository performance assessments. Since the presence of even quite small fractures may control the hydraulic, mechanical and coupled hydromechanical behaviour of the rock mass, a key of the work has been to explore the extent to which these can be upscaled and represented by 'equivalent' continuum properties appropriate PA calculations. From these general aims the BMT was set-up as a numerical study of a large scale reference problem. Analysing this reference problem should: help explore how different means of simplifying the geometrical detail of a site, with its implications on model parameters, ('upscaling') impacts model predictions of relevance to repository performance, explore to what extent the THM-coupling needs to be considered in relation to PA-measures, compare the uncertainties in upscaling (both to uncertainty on how to upscale or uncertainty that arises due to the upscaling processes) and consideration of THM couplings with the inherent uncertainty and spatial variability of the site specific data. Furthermore, it has been an essential component of the work that individual teams not only produce numerical results but are forced to make their own judgements and to provide the proper justification for their conclusions based on their analysis. It should also be understood that conclusions drawn will partly be specific to the problem analysed, in particular as it mainly concerns a 2D application. This means that specific conclusions may have limited applicability to real problems in

  17. DECOVALEX III III/BENCHPAR PROJECTS. Approaches to Upscaling Thermal-Hydro-Mechanical Processes in a Fractured Rock. Mass and its Significance for Large-Scale Repository Performance Assessment. Summary of Findings. Report of BMT2/WP3

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Johan (comp.) [JA Streamflow AB, Aelvsjoe (Sweden); Staub, Isabelle (comp.) [Golder Associates AB, Stockholm (Sweden); Knight, Les (comp.) [Nirex UK Ltd, Oxon (United Kingdom)

    2005-02-15

    The Benchmark Test 2 of DECOVALEX III and Work Package 3 of BENCHPAR concerns the upscaling Thermal (T), Hydrological (H) and Mechanical (M) processes in a fractured rock mass and its significance for large-scale repository performance assessment. The work is primarily concerned with the extent to which various thermo-hydro-mechanical couplings in a fractured rock mass adjacent to a repository are significant in terms of solute transport typically calculated in large-scale repository performance assessments. Since the presence of even quite small fractures may control the hydraulic, mechanical and coupled hydromechanical behaviour of the rock mass, a key of the work has been to explore the extent to which these can be upscaled and represented by 'equivalent' continuum properties appropriate PA calculations. From these general aims the BMT was set-up as a numerical study of a large scale reference problem. Analysing this reference problem should: help explore how different means of simplifying the geometrical detail of a site, with its implications on model parameters, ('upscaling') impacts model predictions of relevance to repository performance, explore to what extent the THM-coupling needs to be considered in relation to PA-measures, compare the uncertainties in upscaling (both to uncertainty on how to upscale or uncertainty that arises due to the upscaling processes) and consideration of THM couplings with the inherent uncertainty and spatial variability of the site specific data. Furthermore, it has been an essential component of the work that individual teams not only produce numerical results but are forced to make their own judgements and to provide the proper justification for their conclusions based on their analysis. It should also be understood that conclusions drawn will partly be specific to the problem analysed, in particular as it mainly concerns a 2D application. This means that specific conclusions may have limited applicability

  18. Return of visual function after bilateral visual loss following flow diversion embolization of a giant ophthalmic aneurysm due to both reduction in mass effect and reduction in aneurysm pulsation.

    Science.gov (United States)

    Patel, Saharsh; Fargen, Kyle M; Peters, Keith; Krall, Peter; Samy, Hazem; Hoh, Brian L

    2015-01-01

    Large and giant paraclinoid aneurysms are challenging to treat by either surgical or endovascular means. Visual dysfunction secondary to optic nerve compression and its relationship with aneurysm size, pulsation and thrombosis is poorly understood. We present a patient with a giant paraclinoid aneurysm resulting in bilateral visual loss that worsened following placement of a Pipeline Embolization Device and adjunctive coiling. Visual worsening occurred in conjunction with aneurysm thrombosis, increase in maximal aneurysm diameter and new adjacent edema. Her visual function spontaneously improved in a delayed fashion to better than pre-procedure, in conjunction with reduced aneurysmal mass effect, size and pulsation artifact on MRI. This report documents detailed ophthalmologic and MRI evidence for the role of thrombosis, aneurysm mass effect and aneurysm pulsation as causative etiologies for both cranial nerve dysfunction and delayed resolution following flow diversion treatment of large cerebral aneurysms. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  19. Probing Hypergiant Mass Loss with Adaptive Optics Imaging and Polarimetry in the Infrared: MMT-Pol and LMIRCam Observations of IRC +10420 and VY Canis Majoris

    Science.gov (United States)

    Shenoy, Dinesh P.; Jones, Terry J.; Packham, Chris; Lopez-Rodriguez, Enrique

    2015-07-01

    We present 2-5 μm adaptive optics (AO) imaging and polarimetry of the famous hypergiant stars IRC +10420 and VY Canis Majoris. The imaging polarimetry of IRC +10420 with MMT-Pol at 2.2 μ {m} resolves nebular emission with intrinsic polarization of 30%, with a high surface brightness indicating optically thick scattering. The relatively uniform distribution of this polarized emission both radially and azimuthally around the star confirms previous studies that place the scattering dust largely in the plane of the sky. Using constraints on scattered light consistent with the polarimetry at 2.2 μ {m}, extrapolation to wavelengths in the 3-5 μm band predicts a scattered light component significantly below the nebular flux that is observed in our Large Binocular Telescope/LMIRCam 3-5 μm AO imaging. Under the assumption this excess emission is thermal, we find a color temperature of ˜500 K is required, well in excess of the emissivity-modified equilibrium temperature for typical astrophysical dust. The nebular features of VY CMa are found to be highly polarized (up to 60%) at 1.3 μm, again with optically thick scattering required to reproduce the observed surface brightness. This star’s peculiar nebular feature dubbed the “Southwest Clump” is clearly detected in the 3.1 μm polarimetry as well, which, unlike IRC +10420, is consistent with scattered light alone. The high intrinsic polarizations of both hypergiants’ nebulae are compatible with optically thick scattering for typical dust around evolved dusty stars, where the depolarizing effect of multiple scatters is mitigated by the grains’ low albedos. Observations reported here were obtained at the MMT Observatory, a joint facility of the Smithsonian Institution and the University of Arizona.

  20. Short-term variability and mass loss in Be stars. II. Physical taxonomy of photometric variability observed by the Kepler spacecraft

    Science.gov (United States)

    Rivinius, Th.; Baade, D.; Carciofi, A. C.

    2016-09-01

    Context. Classical Be stars have been established as pulsating stars. Space-based photometric monitoring missions contributed significantly to that result. However, whether Be stars are just rapidly rotating SPB or β Cep stars, or whether they have to be understood differently, remains debated in the view of their highly complex power spectra. Aims: Kepler data of three known Be stars are re-visited to establish their pulsational nature and assess the properties of additional, non-pulsational variations. The three program stars turned out to be one inactive Be star, one active, continuously outbursting Be star, and one Be star transiting from a non-outbursting into an outbursting phase, thus forming an excellent sample to distill properties of Be stars in the various phases of their life-cycle. Methods: The Kepler data was first cleaned from any long-term variability with Lomb-Scargle based pre-whitening. Then a Lomb-Scargle analysis of the remaining short-term variations was compared to a wavelet analysis of the cleaned data. This offers a new view on the variability, as it enables us to see the temporal evolution of the variability and phase relations between supposed beating phenomena, which are typically not visualized in a Lomb-Scargle analysis. Results: The short-term photometric variability of Be stars must be disentangled into a stellar and a circumstellar part. The stellar part is on the whole not different from what is seen in non-Be stars. However, some of the observed phenomena might be to be due to resonant mode coupling, a mechanism not typically considered for B-type stars. Short-term circumstellar variability comes in the form of either a group of relatively well-defined, short-lived frequencies during outbursts, which are called Štefl frequencies, and broad bumps in the power spectra, indicating aperiodic variability on a time scale similar to typical low-order g-mode pulsation frequencies, rather than true periodicity. Conclusions: From a

  1. Expert Coaching in Weight Loss: Retrospective Analysis.

    Science.gov (United States)

    Painter, Stefanie Lynn; Ahmed, Rezwan; Kushner, Robert F; Hill, James O; Lindquist, Richard; Brunning, Scott; Margulies, Amy

    2018-03-13

    Providing coaches as part of a weight management program is a common practice to increase participant engagement and weight loss success. Understanding coach and participant interactions and how these interactions impact weight loss success needs to be further explored for coaching best practices. The purpose of this study was to analyze the coach and participant interaction in a 6-month weight loss intervention administered by Retrofit, a personalized weight management and Web-based disease prevention solution. The study specifically examined the association between different methods of coach-participant interaction and weight loss and tried to understand the level of coaching impact on weight loss outcome. A retrospective analysis was performed using 1432 participants enrolled from 2011 to 2016 in the Retrofit weight loss program. Participants were males and females aged 18 years or older with a baseline body mass index of ≥25 kg/m², who also provided at least one weight measurement beyond baseline. First, a detailed analysis of different coach-participant interaction was performed using both intent-to-treat and completer populations. Next, a multiple regression analysis was performed using all measures associated with coach-participant interactions involving expert coaching sessions, live weekly expert-led Web-based classes, and electronic messaging and feedback. Finally, 3 significant predictors (Pcoaching session attendance (Pcoaching sessions, attending 60% of live weekly Web-based classes, and receiving a minimum of 1 food log feedback day per week were associated with clinically significant weight loss. Participant's one-on-one expert coaching session attendance, live weekly expert-led interactive Web-based class attendance, and the number of food log feedback days per week from expert coach were significant predictors of weight loss in a 6-month intervention. ©Stefanie Lynn Painter, Rezwan Ahmed, Robert F Kushner, James O Hill, Richard Lindquist, Scott

  2. Expert Coaching in Weight Loss: Retrospective Analysis

    Science.gov (United States)

    Kushner, Robert F; Hill, James O; Lindquist, Richard; Brunning, Scott; Margulies, Amy

    2018-01-01

    Background Providing coaches as part of a weight management program is a common practice to increase participant engagement and weight loss success. Understanding coach and participant interactions and how these interactions impact weight loss success needs to be further explored for coaching best practices. Objective The purpose of this study was to analyze the coach and participant interaction in a 6-month weight loss intervention administered by Retrofit, a personalized weight management and Web-based disease prevention solution. The study specifically examined the association between different methods of coach-participant interaction and weight loss and tried to understand the level of coaching impact on weight loss outcome. Methods A retrospective analysis was performed using 1432 participants enrolled from 2011 to 2016 in the Retrofit weight loss program. Participants were males and females aged 18 years or older with a baseline body mass index of ≥25 kg/m², who also provided at least one weight measurement beyond baseline. First, a detailed analysis of different coach-participant interaction was performed using both intent-to-treat and completer populations. Next, a multiple regression analysis was performed using all measures associated with coach-participant interactions involving expert coaching sessions, live weekly expert-led Web-based classes, and electronic messaging and feedback. Finally, 3 significant predictors (Pcoaching session attendance (Pcoaching sessions, attending 60% of live weekly Web-based classes, and receiving a minimum of 1 food log feedback day per week were associated with clinically significant weight loss. Conclusions Participant’s one-on-one expert coaching session attendance, live weekly expert-led interactive Web-based class attendance, and the number of food log feedback days per week from expert coach were significant predictors of weight loss in a 6-month intervention. PMID:29535082

  3. Weight Loss

    Science.gov (United States)

    ... Rights Employment Discrimination Health Care Professionals Law Enforcement Driver's License For Lawyers Food & Fitness Home Food MyFoodAdvisor ... Fit Types of Activity Weight Loss Assess Your Lifestyle Getting Started Food Choices In My Community Home ...

  4. Hidden loss

    DEFF Research Database (Denmark)

    Kieffer-Kristensen, Rikke; Johansen, Karen Lise Gaardsvig

    2013-01-01

    to participate. RESULTS: All children were affected by their parents' ABI and the altered family situation. The children's expressions led the authors to identify six themes, including fear of losing the parent, distress and estrangement, chores and responsibilities, hidden loss, coping and support. The main......PRIMARY OBJECTIVE: The purpose of this study was to listen to and learn from children showing high levels of post-traumatic stress symptoms after parental acquired brain injury (ABI), in order to achieve an in-depth understanding of the difficulties the children face in their everyday lives...... finding indicates that the children experienced numerous losses, many of which were often suppressed or neglected by the children to protect the ill parents. CONCLUSIONS: The findings indicated that the children seemed to make a special effort to hide their feelings of loss and grief in order to protect...

  5. Amiodarone-induced hyperthyroidism during massive weight loss following gastric bypass.

    Science.gov (United States)

    Bourron, Olivier; Ciangura, Cécile; Bouillot, Jean-Luc; Massias, Laurent; Poitou, Christine; Oppert, Jean-Michel

    2007-11-01

    Gastric bypass is increasingly used in morbidly obese patients to achieve significant reduction of body weight and fat mass and concurrent improvement in co-morbidities. We report the case of a 53-year-old male patient (141 kg, BMI 50 kg/m2), successfully treated by amiodarone for supraventricular arrythmia, who underwent Roux-en-Y gastric bypass (RYGBP). 6 months after surgery, he had lost 45% of his preoperative weight (44.8% of weight loss was lean mass) and developed amiodarone-induced subclinical hyperthyroidism. We hypothesize the following sequence of events: weight loss after RYGBP, therefore fat loss, decrease in distribution volume of amiodarone inducing iodine overload and hyperthyroidism, reinforcing weight loss and particularly loss of lean mass. This report emphasizes the importance of careful monitoring of weight and body composition changes after RYGBP. In this situation, checking thyroid status is recommended, especially when there is a history of thyroid disease or potentially toxic thyroid medication.

  6. Loss Aversion and Individual Characteristics

    DEFF Research Database (Denmark)

    Hjorth, Katrine; Fosgerau, Mogens

    2011-01-01

    Many studies have shown that loss aversion affects the valuation of non-market goods. Using stated choice data, this paper presents an empirical investigation of how individual-level loss aversion varies with observable personal characteristics and with the choice context. We investigate loss...... aversion with respect to travel time and money, and find significant loss aversion in both dimensions. The degree of loss aversion in the time dimension is larger than in the money dimension, and depends on age and education. Subjects tend to be more loss averse when the reference is well established....

  7. Hypnotherapy in Weight Loss Treatment.

    Science.gov (United States)

    Cochrane, Gordon; Friesen, John

    1986-01-01

    Investigated effects of hypnosis as a treatment for weight loss among women. The primary hypothesis that hypnosis is an effective treatment for weight loss was confirmed, but seven concomitant variables and the use of audiotapes were not significant contributors to weight loss. (Author/ABB)

  8. Relations of hedonic hunger and behavioral change to weight loss among adults in a behavioral weight loss program utilizing meal-replacement products.

    Science.gov (United States)

    Theim, Kelly R; Brown, Joshua D; Juarascio, Adrienne S; Malcolm, Robert R; O'Neil, Patrick M

    2013-11-01

    Greater self-regulatory behavior usage is associated with greater weight loss within behavioral weight loss treatments. Hedonic hunger (i.e., susceptibility to environmental food cues) may impede successful behavior change and weight loss. Adult men and women (N = 111, body mass index M ± SD = 35.89 ± 6.97 kg/m(2)) were assessed before and after a 15-week lifestyle change weight loss program with a partial meal-replacement diet. From pre- to post-treatment, reported weight control behavior usage improved and hedonic hunger decreased, and these changes were inversely related. Individuals with higher hedonic hunger scores at baseline showed the greatest weight loss. Similarly, participants with lower baseline use of weight control behaviors lost more weight, and increased weight control behavior usage was associated with greater weight loss-particularly among individuals with low baseline hedonic hunger. Further study is warranted regarding the significance of hedonic hunger in weight loss treatments.

  9. Losses, inefficiencies and waste in the global food system.

    Science.gov (United States)

    Alexander, Peter; Brown, Calum; Arneth, Almut; Finnigan, John; Moran, Dominic; Rounsevell, Mark D A

    2017-05-01

    Losses at every stage in the food system influence the extent to which nutritional requirements of a growing global population can be sustainably met. Inefficiencies and losses in agricultural production and consumer behaviour all play a role. This paper aims to understand better the magnitude of different losses and to provide insights into how these influence overall food system efficiency. We take a systems view from primary production of agricultural biomass through to human food requirements and consumption. Quantities and losses over ten stages are calculated and compared in terms of dry mass, wet mass, protein and energy. The comparison reveals significant differences between these measurements, and the potential for wet mass figures used in previous studies to be misleading. The results suggest that due to cumulative losses, the proportion of global agricultural dry biomass consumed as food is just 6% (9.0% for energy and 7.6% for protein), and 24.8% of harvest biomass (31.9% for energy and 27.8% for protein). The highest rates of loss are associated with livestock production, although the largest absolute losses of biomass occur prior to harvest. Losses of harvested crops were also found to be substantial, with 44.0% of crop dry matter (36.9% of energy and 50.1% of protein) lost prior to human consumption. If human over-consumption, defined as food consumption in excess of nutritional requirements, is included as an additional inefficiency, 48.4% of harvested crops were found to be lost (53.2% of energy and 42.3% of protein). Over-eating was found to be at least as large a contributor to food system losses as consumer food waste. The findings suggest that influencing consumer behaviour, e.g. to eat less animal products, or to reduce per capita consumption closer to nutrient requirements, offer substantial potential to improve food security for the rising global population in a sustainable manner.

  10. The analysis of loading losses from tank trucks

    Directory of Open Access Journals (Sweden)

    Jovanović Ana P.

    2006-01-01

    Full Text Available The quantity of loading losses, which are the primary source of evaporative emissions from tank cars and trucks was analyzed in this paper. Loading losses occur as organic vapors in "empty" cargo tanks are displaced to the atmosphere by the liquid being loaded into the tanks. Emissions from loading petroleum liquid were estimated using three methods: the API (American Petroleum Institute method, the VDI (Verein Deutscher Ingenieure -Association of German Engineers method and the Yugoslav Standard JUS B.HO.531 method. The mass of evaporative losses from loading operations is a function of the following parameters: the method of loading the cargo, the physical and chemical characteristics of the cargo and the ambient temperature during loading. Evaporation losses from the loading of motor gasoline (MB-95, BMB-95, MB-98 and MB-86 and diesel fuels (D-2, Euro D-2 were calculated. Losses on a monthly and annual basis were presented for an assumed amount of loaded cargo. It was estimated that the highest loading losses occur in the summer period because of high ambient daily temperatures and in the period of higher transporting levels. It should be pointed out that the loading losses of diesel fuel calculated using an empirical coefficient according to JUS B.HO.531 are significantly higher in comparison with the loading losses calculated using emission factors from the EPA and the VDI method. The gasoline loading losses calculated using emission factors derived from the three methods are similar.

  11. Issues in characterizing resting energy expenditure in obesity and after weight loss

    Directory of Open Access Journals (Sweden)

    Anja eBosy-Westphal

    2013-03-01

    Full Text Available Normalization of resting energy expenditure (REE for body composition using the 2-compartment model (fat mass, FM and fat-free mass, FFM has inherent limitations for the interpretation of REE and may lead to erroneous conclusions when comparing people with a wide range of adiposity as well as before and after substantial weight loss. We compared different methods of REE normalization: (i for FFM and FM (ii by the inclusion of %FM as a measure of adiposity and (iii based on organ and tissue masses. Results were compared between healthy subjects with different degrees of adiposity as well as within subject before and after weight loss. Normalizing REE from an REE vs. FFM and FM equation that (i was derived in obese participants and applied to lean people or (ii was derived before weight loss and applied after weight loss leads to the erroneous conclusion of a lower metabolic rate (i in lean persons and (ii after weight loss. This is revealed by the normalization of REE for organ and tissue masses that was not significantly different between lean and obese or between baseline and after weight loss. There is evidence for an increasing specific metabolic rate of FFM with increasing %FM that could be explained by a higher contribution of liver, kidney and heart mass to FFM in obesity. Using REE vs. FFM and FM equations specific for different levels of adiposity (% fat mass eliminated differences in REE before and after weight loss in women. In conclusion, the most established method for normalization of REE based on FFM and FM may lead to spurious conclusions about metabolic rate in obesity and the phenomenon of weight loss-associated adaptive thermogenesis. Using % fat mass-specific REE prediction from FFM and FM in kg may improve the normalization of REE when subjects with wide differences in % fat mass are investigated.

  12. Body mass index influences infliximab post-infusion levels and correlates with prospective loss of response to the drug in a cohort of inflammatory bowel disease patients under maintenance therapy with Infliximab.

    Directory of Open Access Journals (Sweden)

    Franco Scaldaferri

    Full Text Available Infliximab is an effective treatment for inflammatory bowel disease (IBD. Studies differ regarding the influence of body mass index (BMI on the response to infliximab, with the majority of studies indicating that increased BMI may be associated with a poorer response to Infliximab. However, the pharmacokinetic mechanisms causing this have not yet been reported.Examine the correlation between BMI/immunosuppressant use with clinical response, trough and post-infusion levels of infliximab, tumour necrosis factor-α(TNF-α and anti-drug antibodies(ATI, and determine if these factors can predict future response.We collected serum from 24 patients receiving Infliximab before and 30 minutes following infusion. Clinical parameters were collected retrospectively and prospectively. ELISA measurements of infliximab, TNF-α and ATI were performed.We confirmed that patients with higher infliximab trough levels have a better response rate and that patients with an elevated BMI display a higher rate of loss of response (20%. Patients with a higher BMI had elevated post-infusion levels of infliximab. Additionally, the ratio of IFX/TNF-α trough levels correlated with clinical response to the following infusion.This study confirms that an elevated BMI is associated with a poorer response to infliximab. For the first time, we describe that a higher BMI correlates with higher post-infusion levels, however this does not correlate with a higher rate of response to the drug, suggesting that circulating drug levels do not correlate with tissue levels. Furthermore, in our small cohort of patients, we identified a possible predictive marker of future response to treatment which may be used to guide dose escalation and predict non-response to infliximab.

  13. Determinants of weight loss after vertical banded gastroplasty.

    Science.gov (United States)

    Westerterp, K R; Saris, W H; Soeters, P B; ten Hoor, F

    1991-08-01

    Weight loss after gastric partition is highly variable even when the operation itself has been successful. We studied changes in body composition in relation to energy expenditure before and one year after surgery in one woman and five men, age 20-38 years, and BMI 42-62 kg/m2. Observations were performed shortly before, and 6, 12, 27 and 54 weeks after surgery. Body composition was measured with hydrostatic weighing and isotope dilution, and energy expenditure over 24 h (24EE) and during complete rest (sleeping metabolic rate (SMR)) with a respiration chamber and in five of the six subjects under daily living conditions over two-week intervals with doubly labeled water (average daily metabolic rate (ADMR). Weight loss and fat loss over the full observation period until 54 weeks after surgery was 54 +/- 8 and 43 +/- 9 kg (mean +/- s.e.m.), respectively. There was a more than three-fold difference in fat loss between the subject losing most, i.e. 70 kg, and the subject losing least, i.e. 20 kg. Fat loss was not related to initial fat mass in this group of six subjects but there was a significant negative relation with the loss of protein mass. There was a strong negative relation between fat loss and activity level of the subjects expressed as the quotient ADMR/SMR. These results show the contrary from what would be expected. Reduction of fat mass after successful gastric partition is highest in those subjects having the lowest physical activity level (before and) after surgery; these subjects lose less fat-free mass.

  14. Quantification of surgical blood loss.

    Science.gov (United States)

    Lee, Marcel H; Ingvertsen, Britt T; Kirpensteijn, Jolle; Jensen, Asger L; Kristensen, Annemarie T

    2006-06-01

    To compare gravimetric and colorimetric methods of quantifying surgical blood loss, and to determine if there is a correlation between preoperative hemostatic tests (buccal mucosa bleeding time [BMBT] and intraoperative blood loss). Prospective clinical study. Dogs (n=15) admitted for cutaneous tumor excision, orthopedic procedure, or exploratory laparotomy. Intraoperative blood loss was quantified by measuring irrigation fluid and weighing surgical sponges used for blood and fluid collection during surgery. Results of gravimetric measurements were then correlated to blood loss quantified using spectrophotometric analysis of hemoglobin (Hb) content. Hemostatic variables including BMBT were measured before surgery and compared with the calculated amount of blood loss. Blood loss quantified by gravimetric measurement showed a significant correlation with colorimetric determination of Hb content in surgical sponges and collected irrigation fluid (r=0.93, P<.0001). BMBT correlated weakly but significantly with intraoperative blood loss (r=0.56, P<.05). Quantifying intraoperative blood loss using spectrophotometric Hb analysis accurately assessed the amount of blood loss; however, it is a time-consuming procedure, primarily applicable as a research tool. Gravimetric evaluation of intraoperative blood loss was found to be an accurate method, which can be recommended for use in a clinical setting. Estimation of blood loss using a gravimetric method is accurate and applicable in the clinical setting and provides surgeons with a simple and objective tool to evaluate intraoperative blood loss.

  15. Solid Loss of Carrots During Simulated Gastric Digestion.

    Science.gov (United States)

    Kong, Fanbin; Singh, R Paul

    2011-03-01

    The knowledge of solid loss kinetics of foods during digestion is crucial for understanding the factors that constrain the release of nutrients from the food matrix and their fate of digestion. The objective of this study was to investigate the solid loss of carrots during simulated gastric digestion as affected by pH, temperature, viscosity of gastric fluids, mechanical force present in stomach, and cooking. Cylindrical carrot samples were tested by static soaking method and using a model stomach system. The weight retention, moisture, and loss of dry mass were determined. The results indicated that acid hydrolysis is critical for an efficient mass transfer and carrot digestion. Internal resistance rather than external resistance is dominant in the transfer of soluble solids from carrot to gastric fluid. Increase in viscosity of gastric fluid by adding 0.5% gum (w/w) significantly increased the external resistance and decreased mass transfer rate of carrots in static soaking. When mechanical force was not present, 61% of the solids in the raw carrot samples were released into gastric fluid after 4 h of static soaking in simulated gastric juice. Mechanical force significantly increased solid loss by causing surface erosion. Boiling increased the disintegration of carrot during digestion that may favor the loss of solids meanwhile reducing the amount of solids available for loss in gastric juice. Weibull function was successfully used to describe the solid loss of carrot during simulated digestion. The effective diffusion coefficients of solids were calculated using the Fick's second law of diffusion for an infinite cylinder, which are between 0.75 × 10(-11) and 8.72 × 10(-11) m(2)/s, depending on the pH of the gastric fluid.

  16. Significant enhancement of 11-Hydroxy-THC detection by formation of picolinic acid esters and application of liquid chromatography/multi stage mass spectrometry (LC-MS(3) ): Application to hair and oral fluid analysis.

    Science.gov (United States)

    Thieme, Detlef; Sachs, Ulf; Sachs, Hans; Moore, Christine

    2015-07-01

    Formation of picolinic acid esters of hydroxylated drugs or their biotransformation products is a promising tool to improve their mass spectrometric ionization efficiency, alter their fragmentation behaviour and enhance sensitivity and specificity of their detection. The procedure was optimized and tested for the detection of cannabinoids, which proved to be most challenging when dealing with alternative specimens, for example hair and oral fluid. In particular, the detection of the THC metabolites hydroxyl-THC and carboxy-THC requires ultimate sensitivity because of their poor incorporation into hair or saliva. Both biotransformation products are widely accepted as incorporation markers to distinguish drug consumption from passive contamination. The derivatization procedure was carried out by adding a mixture of picolinic acid, 4-(dimethylamino)pyridine and 2-methyl-6-nitrobenzoic anhydride in tetrahydrofuran/triethylamine to the dry extraction residues. Resulting derivatives were found to be very stable and could be reconstituted in aqueous or organic buffers and subsequently analyzed by liquid chromatography-mass spectrometry (LC-MS). Owing to the complex consecutive fragmentation patterns, the application of multistage MS3 proved to be extremely useful for a sensitive identification of doubly picolinated hydroxy-THC in complex matrices. The detection limits - estimated by comparison of corresponding signal-to-noise ratios - increased by a factor of 100 following picolination. All other species examined, like cannabinol, THC, cannabidiol, and carboxy-THC, could also be derivatized exhibiting only moderate sensitivity improvements. The assay was systematically tested using hair samples and exemplarily applied to oral fluid. Concentrations of OH-THC identified in THC-positive hair samples ranged from 0.02 to 0.29pg/mg. Copyright © 2014 John Wiley & Sons, Ltd.

  17. Identification by Molecular Methods and Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry and Antifungal Susceptibility Profiles of Clinically Significant Rare Aspergillus Species in a Referral Chest Hospital in Delhi, India.

    Science.gov (United States)

    Masih, Aradhana; Singh, Pradeep K; Kathuria, Shallu; Agarwal, Kshitij; Meis, Jacques F; Chowdhary, Anuradha

    2016-09-01

    Aspergillus species cause a wide spectrum of clinical infections. Although Aspergillus fumigatus and Aspergillus flavus remain the most commonly isolated species in aspergillosis, in the last decade, rare and cryptic Aspergillus species have emerged in diverse clinical settings. The present study analyzed the distribution and in vitro antifungal susceptibility profiles of rare Aspergillus species in clinical samples from patients with suspected aspergillosis in 8 medical centers in India. Further, a matrix-assisted laser desorption ionization-time of flight mass spectrometry in-house database was developed to identify these clinically relevant Aspergillus species. β-Tubulin and calmodulin gene sequencing identified 45 rare Aspergillus isolates to the species level, except for a solitary isolate. They included 23 less common Aspergillus species belonging to 12 sections, mainly in Circumdati, Nidulantes, Flavi, Terrei, Versicolores, Aspergillus, and Nigri Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) identified only 8 (38%) of the 23 rare Aspergillus isolates to the species level. Following the creation of an in-house database with the remaining 14 species not available in the Bruker database, the MALDI-TOF MS identification rate increased to 95%. Overall, high MICs of ≥2 μg/ml were noted for amphotericin B in 29% of the rare Aspergillus species, followed by voriconazole in 20% and isavuconazole in 7%, whereas MICs of >0.5 μg/ml for posaconazole were observed in 15% of the isolates. Regarding the clinical diagnoses in 45 patients with positive rare Aspergillus species cultures, 19 (42%) were regarded to represent colonization. In the remaining 26 patients, rare Aspergillus species were the etiologic agent of invasive, chronic, and allergic bronchopulmonary aspergillosis, allergic fungal rhinosinusitis, keratitis, and mycetoma. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  18. Identification by Molecular Methods and Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry and Antifungal Susceptibility Profiles of Clinically Significant Rare Aspergillus Species in a Referral Chest Hospital in Delhi, India

    Science.gov (United States)

    Masih, Aradhana; Singh, Pradeep K.; Kathuria, Shallu; Agarwal, Kshitij

    2016-01-01

    Aspergillus species cause a wide spectrum of clinical infections. Although Aspergillus fumigatus and Aspergillus flavus remain the most commonly isolated species in aspergillosis, in the last decade, rare and cryptic Aspergillus species have emerged in diverse clinical settings. The present study analyzed the distribution and in vitro antifungal susceptibility profiles of rare Aspergillus species in clinical samples from patients with suspected aspergillosis in 8 medical centers in India. Further, a matrix-assisted laser desorption ionization–time of flight mass spectrometry in-house database was developed to identify these clinically relevant Aspergillus species. β-Tubulin and calmodulin gene sequencing identified 45 rare Aspergillus isolates to the species level, except for a solitary isolate. They included 23 less common Aspergillus species belonging to 12 sections, mainly in Circumdati, Nidulantes, Flavi, Terrei, Versicolores, Aspergillus, and Nigri. Matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) identified only 8 (38%) of the 23 rare Aspergillus isolates to the species level. Following the creation of an in-house database with the remaining 14 species not available in the Bruker database, the MALDI-TOF MS identification rate increased to 95%. Overall, high MICs of ≥2 μg/ml were noted for amphotericin B in 29% of the rare Aspergillus species, followed by voriconazole in 20% and isavuconazole in 7%, whereas MICs of >0.5 μg/ml for posaconazole were observed in 15% of the isolates. Regarding the clinical diagnoses in 45 patients with positive rare Aspergillus species cultures, 19 (42%) were regarded to represent colonization. In the remaining 26 patients, rare Aspergillus species were the etiologic agent of invasive, chronic, and allergic bronchopulmonary aspergillosis, allergic fungal rhinosinusitis, keratitis, and mycetoma. PMID:27413188

  19. Neutrino mass matrix

    International Nuclear Information System (INIS)

    Strobel, E.L.

    1985-01-01

    Given the many conflicting experimental results, examination is made of the neutrino mass matrix in order to determine possible masses and mixings. It is assumed that the Dirac mass matrix for the electron, muon, and tau neutrinos is similar in form to those of the quarks and charged leptons, and that the smallness of the observed neutrino masses results from the Gell-Mann-Ramond-Slansky mechanism. Analysis of masses and mixings for the neutrinos is performed using general structures for the Majorana mass matrix. It is shown that if certain tentative experimental results concerning the neutrino masses and mixing angles are confirmed, significant limitations may be placed on the Majorana mass matrix. The most satisfactory simple assumption concerning the Majorana mass matrix is that it is approximately proportional to the Dirac mass matrix. A very recent experimental neutrino mass result and its implications are discussed. Some general properties of matrices with structure similar to the Dirac mass matrices are discussed

  20. Weight loss in orthognathic surgery: a clinical study.

    Science.gov (United States)

    Hammond, Douglas; Williams, Rhodri W; Juj, Kiranjit; O'Connell, Susan; Isherwood, Grant; Hammond, Nichola

    2015-09-01

    To analyse weight change, body composition change and Body Mass Index change in patients undergoing orthognathic surgery. A service evaluation was undertaken in orthognathic patients pre-operatively and at 4 weeks post-surgery. Queen Elizabeth Hospital Birmingham outpatient department. Thirty-one patients scheduled for single- or two-jaw orthognathic surgery and rigid internal fixation. Immediately pre-operatively and at 4 weeks post-surgery the following information was gathered: (1) patient height; (2) patient weight (kg); (3) Patient Body Mass Index; and (4) patient body fat percentage. In the 4-week post-operative period, the average weight loss was -4·96 kg (range: -9·6 to +3·0 kg), with a body fat reduction of -3·07% (range: -5·80% to +2·30%) and an average reduction in Body Mass Index of -1·63 (range: -3·4 to +0·8). There was no statistically significant difference in weight loss (P = 0·1562) or body fat composition change (P = 0·2391) between single- or two-jaw surgery. There was no statistically significant difference in weight loss (P = 0·4858) or body fat composition change (P = 0·5321) between male and female patients. Weight loss observed was similar to that reported in studies using inter-maxillary fixation. Closer psychological and dietetic support is needed for patients who have a low normal or underweight Body Mass Index. Better and more bespoke tailored Oral Nutritional Supplementation must be provided for all orthognathic surgery patients to potentially reduce this significant weight loss.

  1. Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction

    Directory of Open Access Journals (Sweden)

    Wood Richard J

    2006-05-01

    Full Text Available Abstract Background Diets that restrict carbohydrate (CHO have proven to be a successful dietary treatment of obesity for many people, but the degree of weight loss varies across individuals. The extent to which genetic factors associate with the magnitude of weight loss induced by CHO restriction is unknown. We examined associations among polymorphisms in candidate genes and weight loss in order to understand the physiological factors influencing body weight responses to CHO restriction. Methods We screened for genetic associations with weight loss in 86 healthy adults who were instructed to restrict CHO to a level that induced a small level of ketosis (CHO ~10% of total energy. A total of 27 single nucleotide polymorphisms (SNPs were selected from 15 candidate genes involved in fat digestion/metabolism, intracellular glucose metabolism, lipoprotein remodeling, and appetite regulation. Multiple linear regression was used to rank the SNPs according to probability of association, and the most significant associations were analyzed in greater detail. Results Mean weight loss was 6.4 kg. SNPs in the gastric lipase (LIPF, hepatic glycogen synthase (GYS2, cholesteryl ester transfer protein (CETP and galanin (GAL genes were significantly associated with weight loss. Conclusion A strong association between weight loss induced by dietary CHO restriction and variability in genes regulating fat digestion, hepatic glucose metabolism, intravascular lipoprotein remodeling, and appetite were detected. These discoveries could provide clues to important physiologic adaptations underlying the body mass response to CHO restriction.

  2. Alterations of plasma lysophosphatidylcholine species in obesity and weight loss.

    Directory of Open Access Journals (Sweden)

    Susanne Heimerl

    Full Text Available Obesity and related diseases of the metabolic syndrome contribute to the major health problems in industrialized countries. Alterations in the metabolism of lipid classes and lipid species may significantly be involved in these metabolic overload diseases. However, little is known about specific lipid species in this syndrome and existing data are contradictive.In this study, we quantified plasma lipid species by electrospray ionization tandem mass spectrometry (ESI-MS/MS in obese subjects before and after 3 month weight loss as well as in a control group.The comparison of obese subjects with control subjects before weight loss revealed significantly lower lysophosphatidylcholine (LPC concentrations in obesity. LPC concentrations did not significantly increase during the observed period in the weight loss group. Analysis of LPC species revealed a decrease of most species in obesity and negative correlations with C-reactive protein (CRP and body mass index (BMI. Correlating BMI ratio before and after weight loss with the ratio of total LPC and individual LPC species revealed significant negative relationships of LPC ratios with BMI ratio.Our findings contribute to the contradictive discussion of the role of LPC in obesity and related chronic inflammation strongly supporting pre-existing data in the literature that show a decrease of LPC species in plasma of obese and a potentially anti-inflammatory role in these subjects.

  3. A pilot study of the effects of behavioral weight loss treatment on fibromyalgia symptoms.

    Science.gov (United States)

    Shapiro, Jennifer R; Anderson, Drew A; Danoff-Burg, Sharon

    2005-11-01

    Previous studies have found a relation between weight loss and pain severity in various chronic pain populations. However, there has been little research examining the relation between body mass index (BMI) and fibromyalgia syndrome (FMS). The purpose of this pilot study was to investigate the relationship between BMI and FMS symptoms and to determine if FMS symptoms would decrease following weight loss. Overweight and obese women participated in a 20-week behavioral weight loss treatment. Participants, on average, lost 9.2 lbs (4.4% of their initial weight), and there were significant pre-postimprovements on several outcome measures. Although weight was not significantly related to pain at baseline, weight loss significantly predicted a reduction in FMS, pain interference, body satisfaction, and quality of life (QOL). Findings suggest that behavioral weight loss treatment could be included in the treatment for overweight/obese women with FMS.

  4. Living with vision loss

    Science.gov (United States)

    Diabetes - vision loss; Retinopathy - vision loss; Low vision; Blindness - vision loss ... of visual aids. Some options include: Magnifiers High power reading glasses Devices that make it easier to ...

  5. Weight loss and bone mineral density.

    Science.gov (United States)

    Hunter, Gary R; Plaisance, Eric P; Fisher, Gordon

    2014-10-01

    Despite evidence that energy deficit produces multiple physiological and metabolic benefits, clinicians are often reluctant to prescribe weight loss in older individuals or those with low bone mineral density (BMD), fearing BMD will be decreased. Confusion exists concerning the effects that weight loss has on bone health. Bone density is more closely associated with lean mass than total body mass and fat mass. Although rapid or large weight loss is often associated with loss of bone density, slower or smaller weight loss is much less apt to adversely affect BMD, especially when it is accompanied with high intensity resistance and/or impact loading training. Maintenance of calcium and vitamin D intake seems to positively affect BMD during weight loss. Although dual energy X-ray absorptiometry is normally used to evaluate bone density, it may overestimate BMD loss following massive weight loss. Volumetric quantitative computed tomography may be more accurate for tracking bone density changes following large weight loss. Moderate weight loss does not necessarily compromise bone health, especially when exercise training is involved. Training strategies that include heavy resistance training and high impact loading that occur with jump training may be especially productive in maintaining, or even increasing bone density with weight loss.

  6. Prohibitions against Mourning in Childhood Sibling Loss.

    Science.gov (United States)

    Rosen, Helen

    1985-01-01

    Presents findings from a research study on sibling loss in childhood which support the idea that the loss of a sibling in childhood may be an especially significant loss for a child, in that both internal, family, and societal influences prohibit the opportunity to mourn the loss. (Author/NRB)

  7. Preserving Healthy Muscle during Weight Loss123

    Science.gov (United States)

    Cava, Edda; Yeat, Nai Chien; Mittendorfer, Bettina

    2017-01-01

    Weight loss is the cornerstone of therapy for people with obesity because it can ameliorate or completely resolve the metabolic risk factors for diabetes, coronary artery disease, and obesity-associated cancers. The potential health benefits of diet-induced weight loss are thought to be compromised by the weight-loss–associated loss of lean body mass, which could increase the risk of sarcopenia (low muscle mass and impaired muscle function). The objective of this review is to provide an overview of what is known about weight-loss–induced muscle loss and its implications for overall physical function (e.g., ability to lift items, walk, and climb stairs). The currently available data in the literature show the following: 1) compared with persons with normal weight, those with obesity have more muscle mass but poor muscle quality; 2) diet-induced weight loss reduces muscle mass without adversely affecting muscle strength; 3) weight loss improves global physical function, most likely because of reduced fat mass; 4) high protein intake helps preserve lean body and muscle mass during weight loss but does not improve muscle strength and could have adverse effects on metabolic function; 5) both endurance- and resistance-type exercise help preserve muscle mass during weight loss, and resistance-type exercise also improves muscle strength. We therefore conclude that weight-loss therapy, including a hypocaloric diet with adequate (but not excessive) protein intake and increased physical activity (particularly resistance-type exercise), should be promoted to maintain muscle mass and improve muscle strength and physical function in persons with obesity. PMID:28507015

  8. Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.

    Directory of Open Access Journals (Sweden)

    Fiona McMurray

    Full Text Available The strongest BMI-associated GWAS locus in humans is the FTO gene. Rodent studies demonstrate a role for FTO in energy homeostasis and body composition. The phenotypes observed in loss of expression studies are complex with perinatal lethality, stunted growth from weaning, and significant alterations in body composition. Thus understanding how and where Fto regulates food intake, energy expenditure, and body composition is a challenge. To address this we generated a series of mice with distinct temporal and spatial loss of Fto expression. Global germline loss of Fto resulted in high perinatal lethality and a reduction in body length, fat mass, and lean mass. When ratio corrected for lean mass, mice had a significant increase in energy expenditure, but more appropriate multiple linear regression normalisation showed no difference in energy expenditure. Global deletion of Fto after the in utero and perinatal period, at 6 weeks of age, removed the high lethality of germline loss. However, there was a reduction in weight by 9 weeks, primarily as loss of lean mass. Over the subsequent 10 weeks, weight converged, driven by an increase in fat mass. There was a switch to a lower RER with no overall change in food intake or energy expenditure. To test if the phenotype can be explained by loss of Fto in the mediobasal hypothalamus, we sterotactically injected adeno-associated viral vectors encoding Cre recombinase to cause regional deletion. We observed a small reduction in food intake and weight gain with no effect on energy expenditure or body composition. Thus, although hypothalamic Fto can impact feeding, the effect of loss of Fto on body composition is brought about by its actions at sites elsewhere. Our data suggest that Fto may have a critical role in the control of lean mass, independent of its effect on food intake.

  9. Hair Loss (Alopecia)

    Science.gov (United States)

    ... care Kids’ zone Video library Find a dermatologist Hair loss Overview Hereditary hair loss: Millions of men ... of hair loss can often be successfully treated. Hair loss: Overview Also called alopecia (al-o-PEE- ...

  10. Risk factors for islet loss during culture prior to transplantation.

    Science.gov (United States)

    Kin, Tatsuya; Senior, Peter; O'Gorman, Doug; Richer, Brad; Salam, Abdul; Shapiro, Andrew Mark James

    2008-11-01

    Culturing islets can add great flexibility to a clinical islet transplant program. However, a reduction in the islet mass has been frequently observed during culture and its degree varies. The aim of this study was to identify the risk factors associated with a significant islet loss during culture. One-hundred and four islet preparations cultured in an attempt to use for transplantation constituted this study. After culture for 20 h (median), islet yield significantly decreased from 363 309 +/- 12 647 to 313 035 +/- 10 862 islet equivalent yield (IE) (mean +/- SE), accompanied by a reduction in packed tissue volume from 3.9 +/- 0.1 to 3.0 +/- 0.1 ml and islet index (IE/islet particle count) from 1.20 +/- 0.04 to 1.05 +/- 0.04. Culture did not markedly alter islet purity or percent of trapped islet. Morphology score and viability were significantly improved after culture. Of 104 islet preparations, 37 suffered a substantial islet loss (> 20%) over culture. Factors significantly associated with risk of islet loss identified by univariate analysis were longer cold ischemia time, two-layer method (TLM) preservation, lower islet purity, and higher islet index. Multivariate analysis revealed that independent predictors of islet loss were higher islet index and the use of TLM. This study provides novel information on the link between donor- isolation factors and islet loss during culture.

  11. Policaptil Gel Retard significantly reduces body mass index and hyperinsulinism and may decrease the risk of type 2 diabetes mellitus (T2DM) in obese children and adolescents with family history of obesity and T2DM.

    Science.gov (United States)

    Stagi, Stefano; Lapi, Elisabetta; Seminara, Salvatore; Pelosi, Paola; Del Greco, Paolo; Capirchio, Laura; Strano, Massimo; Giglio, Sabrina; Chiarelli, Francesco; de Martino, Maurizio

    2015-02-15

    Treatments for childhood obesity are critically needed because of the risk of developing co-morbidities, although the interventions are frequently time-consuming, frustrating, difficult, and expensive. We conducted a longitudinal, randomised, clinical study, based on a per protocol analysis, on 133 obese children and adolescents (n = 69 males and 64 females; median age, 11.3 years) with family history of obesity and type 2 diabetes mellitus (T2DM). The patients were divided into three arms: Arm A (n = 53 patients), Arm B (n = 45 patients), and Arm C (n = 35 patients) patients were treated with a low-glycaemic-index (LGI) diet and Policaptil Gel Retard, only a LGI diet, or only an energy-restricted diet (ERD), respectively. The homeostasis model assessment of insulin resistance (HOMA-IR) and the Matsuda, insulinogenic and disposition indexes were calculated at T0 and after 1 year (T1). At T1, the BMI-SD scores were significantly reduced from 2.32 to 1.80 (p 1) in Arm A and from 2.23 to 1.99 (p 13.2% to 5.6%; p 1) and B (p 1) and B (p obese children and adolescents with family history of obesity and T2DM.

  12. Systemic causes of hair loss.

    Science.gov (United States)

    Lin, Richard L; Garibyan, Lilit; Kimball, Alexandra B; Drake, Lynn A

    2016-09-01

    Hair loss is both a common chief complaint by patients and a clinical challenge for physicians, especially general practitioners, yet few dermatological problems yield as much patient satisfaction when resolved as hair loss. The diagnosis is often attributed to androgen-related hair loss, while other causes, some of which ar