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Sample records for short elution time

  1. Impact of ultrasonication time on elution of super heavy oil and its biomarkers from aging soils using a Triton X-100 micellar solution

    International Nuclear Information System (INIS)

    Ji Guodong; Zhou Guohui

    2010-01-01

    An ultrasound-enhanced elution system with Triton X-100 solution was used to remediate aging soils contaminated with super heavy oil. We used GC/MS, SEM, and X-ray diffraction (XRD) to analyze the effect of ultrasonic time (0-1800 s) on the elution of super heavy oil and its three characteristic biomarkers (C 26-34 17α 25-norhopanes, C 26-28 triaromatic steroid [TAS], and C 27-29 methyl triaromatic steroid [MTAS]). The oil and biomarkers remaining in the treated soils followed similar second-order functions with increasing ultrasonication times. Biomarker elution was closely related to carbon numbers in the marker. For C 26-34 17α 25-norhopanes, the smaller molecules were more readily eluted during 0-360 s ultrasound. This trend was reversed upon application of ultrasound during 1080-1800 s, with improved elution of larger molecules and elution followed a similar second-order function. For C 26-28 TAS, smaller molecules were more readily eluted but the elution of larger molecules followed a similar second-order function. For C 27-29 MTAS, elution of larger molecules was close to that of C 26-34 17α 25-norhopanes. Results of SEM and XRD indicated that the mineral and chemical compositions of soils eluted at ultrasonication times of 1080-1800 s closely resembled clean soils.

  2. Short recovery time NMR probe

    International Nuclear Information System (INIS)

    Ramia, M.E.; Martin, C.A.; Jeandrevin, S.

    2011-01-01

    A NMR probe for low frequency and short recovery time is presented in this work. The probe contains the tuning circuit, diode expanders and quarter wavelength networks to protect the receiver from both the amplifier noise and the coil ringing following the transmitter power pulse. It also possesses a coil damper which is activated by of non active components. The probe performance shows a recovery time of about of 15μs a sensitive Q factor reduction and an increase of the signal to noise ratio of about 68% during the reception at a work frequency of 2 MHz. (author)

  3. Time-Fractional Advection-Dispersion Equation (tFADE) to Quantify Aqueous Phase Contaminant Elution from a Trichloroethene (TCE) NAPL Source Zone in Sand Columns

    Science.gov (United States)

    Tick, G. R.; Wei, S.; Sun, H.; Zhang, Y.

    2016-12-01

    Pore-scale heterogeneity, NAPL distribution, and sorption/desorption processes can significantly affect aqueous phase elution and mass flux in porous media systems. The application of a scale-independent fractional derivative model (tFADE) was used to simulate elution curves for a series of columns (5 cm, 7 cm, 15 cm, 25 cm, and 80 cm) homogeneously packed with 20/30-mesh sand and distributed with uniform saturations (7-24%) of NAPL phase trichloroethene (TCE). An additional set of columns (7 cm and 25 cm) were packed with a heterogeneous distribution of quartz sand upon which TCE was emplaced by imbibing the immiscible liquid, under stable displacement conditions, to simulate a spill-type process. The tFADE model was able to better represent experimental elution behavior for systems that exhibited extensive long-term concentration tailing requiring much less parameters compared to typical multi-rate mass transfer models (MRMT). However, the tFADE model was not able to effectively simulate the entire elution curve for such systems with short concentration tailing periods since it assumes a power-law distribution for the dissolution rate for TCE. Such limitations may be solved using the tempered fractional derivative model, which can capture the single-rate mass transfer process and therefore the short elution concentration tailing behavior. Numerical solution for the tempered fractional-derivative model in bounded domains however remains a challenge and therefore requires further study. However, the tFADE model shows excellent promise for understanding impacts on concentration elution behavior for systems in which physical heterogeneity, non-uniform NAPL distribution, and pronounced sorption-desorption effects dominate or are present.

  4. Size distribution of DNA molecules recovered from non-denaturing filter elution

    International Nuclear Information System (INIS)

    Bloecher, D.; Iliakis, G.

    1991-01-01

    DNA fragments removed from the filter during non-denaturing filter elution were collected and loaded on top of neutral sucrose gradients. Their size distribution was determined by low-speed centrifugation in neutral sucrose gradients. The average size of eluted DNA was found to be approximately 110 S; the average size of DNA collected after short elution times was found to be slightly larger than after long elution times. It is concluded that the size of eluted DNA fragments is not correlated with elution rate, and it is proposed that shear forces generated at the filter pores cause degradation of the DNA. Comparison of sedimentation profiles of carefully prepared cellular DNA before and after elution revealed that generated shear forces during elution break down DNA to an extent equivalent to around 20 000 DNA double-strand breaks (dsb) per G 1 cell. The size of DNA fragments decreased with increasing radiation dose; five times more dsb were found than expected after exposure to radiation alone. It is proposed that excess of dsb may derive from the transformation of other radiation-induced lesions to dsb under the action of shear forces generated during elution. (author)

  5. Time-related changes in neointimal tissue coverage of a novel Sirolimus eluting stent

    Energy Technology Data Exchange (ETDEWEB)

    Secco, Gioel Gabrio, E-mail: gioel.gabrio.secco@gmail.com [Interventional Cardiology, “Santi Antonio e Biagio e Cesare Arrigo” Hospital, Alessandria (Italy); NIHR Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust, London (United Kingdom); Mattesini, Alessio [NIHR Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust, London (United Kingdom); Fattori, Rossella; Parisi, Rosario [Interventional Cardiology, “San Salvatore” Hospital, Pesaro (Italy); Castriota, Fausto [GVM Care and Research, Cotignola (Italy); Vercellino, Matteo [Interventional Cardiology, “Santi Antonio e Biagio e Cesare Arrigo” Hospital, Alessandria (Italy); Dall’Ara, Gianni [NIHR Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust, London (United Kingdom); Uguccioni, Lucia; Marinucci, Lucia [Interventional Cardiology, “San Salvatore” Hospital, Pesaro (Italy); De Luca, Giuseppe; Marino, Paolo Nicola [University of Eastern Piedmont, Novara (Italy); Pistis, Gianfranco [Interventional Cardiology, “Santi Antonio e Biagio e Cesare Arrigo” Hospital, Alessandria (Italy); Di Mario, Carlo [NIHR Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust, London (United Kingdom)

    2016-01-15

    Background: DES has reduced rates of restenosis compared with BMS but it has been associated with delayed healing and increase of stent thrombosis. The aim of our study was to evaluate the vascular time-related changes following implantation of a new SES coated with an amorphous silicon carbide that allows faster re-endothelisation (Orsiro-Biotronik). Methods: This prospective registry enrolled STEMI-patients with multi-vessel disease, thus candidates for a two-step procedure. PCI of the culprit lesion was performed with at least one Orsiro stent that was OCT-analysed during the second-step procedure (deferred to 30,90 and 180-days). Results: 16 of the 95 patients with MVD underwent an OCT evaluation of the study device implanted in the culprit lesion during the second-step staged procedure and were enrolled in the present Registry. A total of 3060-struts were analysed. The percentage of uncovered struts was 19.6% at30-days, 1.3% at90-days and 1.8% at180-days (p < 0.001). The percentage of cross section with ≥ 1 uncovered struts were 51.3% at30-days, 6.5% at90-days and 5.7% at180-days (p < 0.001). The percentage of cross sections containing thrombus was 6.2% at30-days while no thrombus was detected both at90 and 180-days. Conclusions: Our data shows that the new Orsiro stent promotes early and persistent strut coverage with low peri-strut thrombus. This pilot OCT evaluation might suggest a low incidence of late adverse events and anticipate safe outcome after early withdrawal of dual antiplatelet therapy. - Highlights: • This is the first serial study comparing coverage at 1, 3, and 6-months in consecutive patients with STEMI; • Aim of our study was to evaluate the vascular time-related changes following implantation of a new SES coated with an amorphous silicon carbide that allows faster re-endothelisation (Orsiro-Biotronik); • The main finding of this pilot study is that the study device presented a fast pattern of intimal coverage, with a thin intimal

  6. Transient nanobubbles in short-time electrolysis

    NARCIS (Netherlands)

    Svetovoy, Vitaly; Sanders, Remco G.P.; Elwenspoek, Michael Curt

    2013-01-01

    Water electrolysis in a microsystem is observed and analyzed on a short-time scale of ∼10 μs. The very unusual properties of the process are stressed. An extremely high current density is observed because the process is not limited by the diffusion of electroactive species. The high current is

  7. Short time ahead wind power production forecast

    International Nuclear Information System (INIS)

    Sapronova, Alla; Meissner, Catherine; Mana, Matteo

    2016-01-01

    An accurate prediction of wind power output is crucial for efficient coordination of cooperative energy production from different sources. Long-time ahead prediction (from 6 to 24 hours) of wind power for onshore parks can be achieved by using a coupled model that would bridge the mesoscale weather prediction data and computational fluid dynamics. When a forecast for shorter time horizon (less than one hour ahead) is anticipated, an accuracy of a predictive model that utilizes hourly weather data is decreasing. That is because the higher frequency fluctuations of the wind speed are lost when data is averaged over an hour. Since the wind speed can vary up to 50% in magnitude over a period of 5 minutes, the higher frequency variations of wind speed and direction have to be taken into account for an accurate short-term ahead energy production forecast. In this work a new model for wind power production forecast 5- to 30-minutes ahead is presented. The model is based on machine learning techniques and categorization approach and using the historical park production time series and hourly numerical weather forecast. (paper)

  8. Short time ahead wind power production forecast

    Science.gov (United States)

    Sapronova, Alla; Meissner, Catherine; Mana, Matteo

    2016-09-01

    An accurate prediction of wind power output is crucial for efficient coordination of cooperative energy production from different sources. Long-time ahead prediction (from 6 to 24 hours) of wind power for onshore parks can be achieved by using a coupled model that would bridge the mesoscale weather prediction data and computational fluid dynamics. When a forecast for shorter time horizon (less than one hour ahead) is anticipated, an accuracy of a predictive model that utilizes hourly weather data is decreasing. That is because the higher frequency fluctuations of the wind speed are lost when data is averaged over an hour. Since the wind speed can vary up to 50% in magnitude over a period of 5 minutes, the higher frequency variations of wind speed and direction have to be taken into account for an accurate short-term ahead energy production forecast. In this work a new model for wind power production forecast 5- to 30-minutes ahead is presented. The model is based on machine learning techniques and categorization approach and using the historical park production time series and hourly numerical weather forecast.

  9. Are anomalously short tunnelling times measurable?

    International Nuclear Information System (INIS)

    Delgado, V.; Muga, J.G.

    1996-01-01

    Low and Mende have analyzed the conditions that would make possible an actual measurement of an anomalously short traversal time through a potential barrier concluding that such a measurement cannot be made because it is not possible to describe the tunnelling of a wave packet initially close to the barrier by the open-quote open-quote usual wave packet space time analysis close-quote close-quote. We complement this work in several ways: It is argued that the described failure of the usual formalism occurs under a set of too restrictive conditions, some of them not physically motivated, so it does not necessarily imply the impossibility of such a measurement. However, by retaining only conditions well motivated on physical grounds we have performed a systematic numerical check which shows that the conclusion by Low and Mende is indeed generally valid. It is shown that, as speculated by Low and Mende, the process is dominated by over the barrier transmission. Copyright copyright 1996 Academic Press, Inc

  10. Risk and timing of clinical events according to diabetic status of patients treated with everolimus-eluting bioresorbable vascular scaffolds versus everolimus-eluting stent: 2-year results from a propensity score matched comparison of ABSORB EXTEND and SPIRIT trials.

    Science.gov (United States)

    Campos, Carlos M; Caixeta, Adriano; Franken, Marcelo; Bartorelli, Antonio L; Whitbourn, Robert J; Wu, Chiung-Jen; Li Paul Kao, Hsien; Rosli, Mohd Ali; Carrie, Didier; De Bruyne, Bernard; Stone, Gregg W; Serruys, Patrick W; Abizaid, Alexandre

    2018-02-15

    to compare the occurrence of clinical events in diabetics treated with the Absorb bioresorbable vascular scaffold (Absorb BVS; Abbott Vascular, Santa Clara, CA) versus everolimus-eluting metal stents (EES; XIENCE V; Abbott Vascular, Santa Clara, CA) BACKGROUND: There are limited data dedicated to clinical outcomes of diabetic patients treated with bioresorbable scaffolds (BRS) at 2-year horizon. The present study included 812 patients in the ABSORB EXTEND study in which a total of 215 diabetic patients were treated with Absorb BVS. In addition, 882 diabetic patients treated with EES in pooled data from the SPIRIT clinical program (SPIRIT II, SPIRIT III and SPIRIT IV trials) were used for comparison by applying propensity score matching using 29 different variables. The primary endpoint was ischemia driven major adverse cardiac events (ID-MACE), including cardiac death, myocardial infarction (MI), and ischemia driven target lesion revascularization (ID-TLR). After 2 years, the ID-MACE rate was 6.5% in the Absorb BVS vs. 8.9% in the Xience group (P = 0.40). There was no difference for MACE components or definite/probable device thrombosis (HR: 1.43 [0.24,8.58]; P = 0.69). The occurrence of MACE was not different for both diabetic status (insulin- and non-insulin-requiring diabetes) in all time points up to the 2-year follow-up for the Absorb and Xience groups. In this largest ever patient-level pooled comparison on the treatment of diabetic patients with BRS out to two years, individuals with diabetes treated with the Absorb BVS had a similar rate of MACE as compared with diabetics treated with the Xience EES. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  11. Design spectra development considering short time histories

    International Nuclear Information System (INIS)

    Weiner, E.O.

    1983-01-01

    Two separate programs, MODQKE and MDOF, were written to provide a capability of obtaining equipment spectra from design spectra. MODQKE generates or modifies acceleration histories to conform with design spectra pertaining to, say, a foundation. MDOF is a simple linear modal superposition program that solves for equipment support histories using the design spectra conforming histories as input. Equipment spectra, then, are obtained from the support histories using MODQKE. MODQKE was written to modify or provide new histories with special attention paid to short seismic records. A technique from the open literature was borrowed to generate an initial history that approximates a given response spectrum. Further refinement is done with smoothing cycles in which several correction signals are added to the history in a way that produces a least squares fit between actual and prescribed spectra. Provision is made for history shaping, a baseline correction, and final scaling. MODQKE performance has been demonstrated with seven examples having zero to ten percent damping ratios, and 2.5 seconds to 20 seconds durations and a variety of target spectra. The examples show the program is inexpensive to use. MDOF is a simple modal superposition program. It has no eigensolver, and the user supplies mode shapes, frequencies, and participation factors as input. Floor spectra can be generated from design spectra by using a history from MODQKE that conforms to the design spectrum as input to MDOF. Floor motions from MDOF can be fed back to MODQKE without modification to obtain the floor spectra. A simple example is given to show how equipment mass effects can be incorporated into the MDOF solution. Any transient solution capability can be used to replace MDOF. For example, a direct transient approach may be desirable if both the equipment and floor structures are to be included in the model with different damping fractions. (orig./HP)

  12. Kālacakra: Shortlies Considerations on Time

    Directory of Open Access Journals (Sweden)

    Adrián Muñoz

    2013-05-01

    Full Text Available This paper calls for a comparative reading of both the Buddhist conception of time and a branch of Western phenomenology. With special emphasis on the Madhyamaka Buddhist school, it discusses the way in which fugacity and impermanence are similarly discussed by French philosopher Gaston Bachelard in his L’intuition de l’instant. In both cases, the stress lies on the fact that duration is but a mental construct lacking true, absolute reality, while at the same time the human being is subjected to hopes of transcendence which, in turn, engender disillusion and delusion.

  13. Inferring interdependencies from short time series

    Indian Academy of Sciences (India)

    Abstract. Complex networks provide an invaluable framework for the study of interlinked dynamical systems. In many cases, such networks are constructed from observed time series by first estimating the ...... does not quantify causal relations (unlike IOTA, or .... Africa_map_regions.svg, which is under public domain.

  14. Phonemes as short time cognitive components

    DEFF Research Database (Denmark)

    Feng, Ling; Hansen, Lars Kai

    2006-01-01

    are the smallest contrastive unit in the sound system of a language. Generalizable components were found deriving from phonemes based on homomorphic filtering features with basic time scale (20 msec). We sparsified the features based on energy as a preprocessing means to eliminate the intrinsic noise. Independent...

  15. Potential barrier classification by short-time measurement

    International Nuclear Information System (INIS)

    Granot, Er'el; Marchewka, Avi

    2006-01-01

    We investigate the short-time dynamics of a delta-function potential barrier on an initially confined wave packet. There are mainly two conclusions: (A) At short times the probability density of the first particles that passed through the barrier is unaffected by it. (B) When the barrier is absorptive (i.e., its potential is imaginary) it affects the transmitted wave function at shorter times than a real potential barrier. Therefore, it is possible to distinguish between an imaginary and a real potential barrier by measuring its effect at short times only on the transmitting wave function

  16. Potential barrier classification by short-time measurement

    Science.gov (United States)

    Granot, Er'El; Marchewka, Avi

    2006-03-01

    We investigate the short-time dynamics of a delta-function potential barrier on an initially confined wave packet. There are mainly two conclusions: (A) At short times the probability density of the first particles that passed through the barrier is unaffected by it. (B) When the barrier is absorptive (i.e., its potential is imaginary) it affects the transmitted wave function at shorter times than a real potential barrier. Therefore, it is possible to distinguish between an imaginary and a real potential barrier by measuring its effect at short times only on the transmitting wave function.

  17. Improving Music Genre Classification by Short-Time Feature Integration

    DEFF Research Database (Denmark)

    Meng, Anders; Ahrendt, Peter; Larsen, Jan

    2005-01-01

    Many different short-time features, using time windows in the size of 10-30 ms, have been proposed for music segmentation, retrieval and genre classification. However, often the available time frame of the music to make the actual decision or comparison (the decision time horizon) is in the range...... of seconds instead of milliseconds. The problem of making new features on the larger time scale from the short-time features (feature integration) has only received little attention. This paper investigates different methods for feature integration and late information fusion for music genre classification...

  18. Investigation of the elution by seawater of caesium and strontium from loaded clinoptilolite

    International Nuclear Information System (INIS)

    Harder, B.R.; Mitchell, I.H.; Smyth, M.J.

    1985-07-01

    Simple investigations of the elution of caesium and strontium from loaded clinoptilolite are described. The clinoptilolite was loaded to levels expected in the British Nuclear Fuels plc SIXEP plant and contacted with seawater at approx. 15 C. (The elution time was measured until about 99% of the caesium and strontium had been eluted.) It was found that 99% of the caesium was eluted in 35 hours but the strontium (with more variable results) took at least 400 hours for 99% elution. (author)

  19. Short-time quantum propagator and Bohmian trajectories

    Science.gov (United States)

    de Gosson, Maurice; Hiley, Basil

    2013-12-01

    We begin by giving correct expressions for the short-time action following the work Makri-Miller. We use these estimates to derive an accurate expression modulo Δt2 for the quantum propagator and we show that the quantum potential is negligible modulo Δt2 for a point source, thus justifying an unfortunately largely ignored observation of Holland made twenty years ago. We finally prove that this implies that the quantum motion is classical for very short times.

  20. Short-time quantum propagator and Bohmian trajectories

    International Nuclear Information System (INIS)

    Gosson, Maurice de; Hiley, Basil

    2013-01-01

    We begin by giving correct expressions for the short-time action following the work Makri–Miller. We use these estimates to derive an accurate expression modulo Δt 2 for the quantum propagator and we show that the quantum potential is negligible modulo Δt 2 for a point source, thus justifying an unfortunately largely ignored observation of Holland made twenty years ago. We finally prove that this implies that the quantum motion is classical for very short times.

  1. The short- and long-term outcomes of percutaneous intervention with drug-eluting stent vs bare-metal stent in saphenous vein graft disease: An updated meta-analysis of all randomized clinical trials.

    Science.gov (United States)

    Kheiri, Babikir; Osman, Mohammed; Abdalla, Ahmed; Ahmed, Sahar; Bachuwa, Ghassan; Hassan, Mustafa

    2018-05-11

    The use of drug-eluting stents (DES) vs bare-metal stents (BMS) in saphenous vein graft (SVG) lesions remains controversial. We conducted a meta-analysis of all randomized clinical trials comparing the outcomes of DES with BMS in SVG percutaneous coronary interventions. A search of PubMed, Embase, the Cochrane Register of Controlled Trials, and Clinicaltrials.gov was performed for all randomized clinical trials. We evaluated the short- and long-term clinical outcomes of the following: all-cause mortality, major adverse cardiovascular events (MACE), definite/probable stent thrombosis, target lesion revascularization (TLR), and target-vessel revascularization (TVR). From a total of 1582 patients in 6 randomized clinical trials, 797 had DES and 785 had BMS. Patients with DES had lower short-term MACE, TLR, and TVR in comparison with BMS (odds ratio [OR]: 0.56, 95% confidence interval [CI]: 0.35-0.91, P = 0.02; OR: 0.43, 95% CI: 0.19-0.99, P = 0.05; and OR: 0.45, 95% CI: 0.22-0.95, P = 0.04, respectively). However, there were no different outcomes for all-cause mortality (P = 0.63) or stent thrombosis (P = 0.21). With long-term follow-up, there were no significant reductions of MACE (P = 0.20), TLR (P = 0.57), TVR (P = 0.07), all-cause mortality (P = 0.29), and stent thrombosis (P = 0.76). The use of DES in SVG lesions was associated with lower short-term MACE, TLR, and TVR in comparison with BMS. However, there were no significant differences with long-term follow-up. © 2018 Wiley Periodicals, Inc.

  2. Short-versus long-term Dual Antiplatelet therapy after drug-eluting stent implantation in women versus men: A sex-specific patient-level pooled-analysis of six randomized trials.

    Science.gov (United States)

    Sawaya, Fadi J; Morice, Marie-Claude; Spaziano, Marco; Mehran, Roxana; Didier, Romain; Roy, Andrew; Valgimigli, Marco; Kim, Hyo-Soo; Woo Park, Kyung; Hong, Myeong-Ki; Kim, Byeong-Keuk; Jang, Yangsoo; Feres, Fausto; Abizaid, Alexandre; Costa, Ricardo A; Colombo, Antonio; Chieffo, Alaide; Giustino, Gennaro; Stone, Gregg W; Bhatt, Deepak L; Palmerini, Tullio; Gilard, Martine

    2017-02-01

    Whether the efficacy and safety of dual antiplatelet therapy (DAPT) are uniform between sexes is unclear. We sought to compare clinical outcomes between short- (≤6 months) versus long-term (≥1 year) DAPT after drug-eluting stent (DES) placement in women and men. We pooled individual patient data from 6 randomized trials of DAPT (EXCELLENT, OPTIMIZE, PRODIGY, RESET, SECURITY, ITALIC PLUS). The primary outcome was 1-year risk of major adverse cardiac events (MACE). The main secondary outcome was 1-year risk of any bleeding. Out of the 11,473 randomized patients included in the pooled dataset, 3,454 (30%) were females. At 1-year follow-up, women had higher risk of MACE (3.6% vs. 2.8%; P = 0.01) but similar risk of bleeding (1.9% vs. 1.6%; P = 0.16) as compared with men. Compared with long-term DAPT, short-term DAPT was associated with similar rates of MACE in both women (HR 0.88; 95% CI 0.62-1.25) and men (HR 1.25; 95% CI 0.95-1.6; P interaction = 0.08)]. At 1-year follow-up, short-term DAPT was associated with lower rates of bleeding as compared with long-term DAPT in both women (HR 0.84; 95% CI 0.51-1.37) and men (HR 0.58; 95% CI 0.40-0.84; P-interaction = 0.25). The presence of MVD was associated with higher MACE rates in the short-term DAPT group in women (HR: 1.16; CI 0.60-2.23) and men (HR: 2.29; CI 1.22-4.29; P interaction = 0.25). Short-term DAPT is associated with similar rates of MACE but lower risk of bleeding when as compared with prolonged DAPT. There was no significant difference between sexes in the population studied. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  3. EVALUATION OF PETROLEUM HYDROCARBONS ELUTION FROM SOIL

    Directory of Open Access Journals (Sweden)

    Janina Piekutin

    2015-06-01

    Full Text Available The paper presents studies on oil removal from soil by means of water elution with a help of shaking out the contaminants from the soil. The tests were performed on simulated soil samples contaminated with a mixture of petroleum hydrocarbons. The study consisted in recording the time influence and the number of elution cycles to remove contaminants from the soil. The samples were then subject to the determination of petroleum hydrocarbons, aliphatic hydrocarbons, and BTEX compounds (benzene, toluene, ethylbenzene, xylene. Due to adding various concentrations of petroleum into particular soil samples and applying different shaking times, it was possible to find out the impact of petroleum content and sample shaking duration on the course and possibility of petroleum substances removal by means of elution process.

  4. Short-time quantum dynamics of sharp boundaries potentials

    Energy Technology Data Exchange (ETDEWEB)

    Granot, Er' el, E-mail: erel@ariel.ac.il; Marchewka, Avi

    2015-02-15

    Despite the high prevalence of singular potential in general, and rectangular potentials in particular, in applied scattering models, to date little is known about their short time effects. The reason is that singular potentials cause a mixture of complicated local as well as non-local effects. The object of this work is to derive a generic method to calculate analytically the short-time impact of any singular potential. In this paper it is shown that the scattering of a smooth wavefunction on a singular potential is totally equivalent, in the short-time regime, to the free propagation of a singular wavefunction. However, the latter problem was totally addressed analytically in Ref. [7]. Therefore, this equivalency can be utilized in solving analytically the short time dynamics of any smooth wavefunction at the presence of a singular potentials. In particular, with this method the short-time dynamics of any problem where a sharp boundaries potential (e.g., a rectangular barrier) is turned on instantaneously can easily be solved analytically.

  5. Short-time quantum dynamics of sharp boundaries potentials

    Science.gov (United States)

    Granot, Er'el; Marchewka, Avi

    2015-02-01

    Despite the high prevalence of singular potential in general, and rectangular potentials in particular, in applied scattering models, to date little is known about their short time effects. The reason is that singular potentials cause a mixture of complicated local as well as non-local effects. The object of this work is to derive a generic method to calculate analytically the short-time impact of any singular potential. In this paper it is shown that the scattering of a smooth wavefunction on a singular potential is totally equivalent, in the short-time regime, to the free propagation of a singular wavefunction. However, the latter problem was totally addressed analytically in Ref. [7]. Therefore, this equivalency can be utilized in solving analytically the short time dynamics of any smooth wavefunction at the presence of a singular potentials. In particular, with this method the short-time dynamics of any problem where a sharp boundaries potential (e.g., a rectangular barrier) is turned on instantaneously can easily be solved analytically.

  6. Short-time quantum dynamics of sharp boundaries potentials

    International Nuclear Information System (INIS)

    Granot, Er'el; Marchewka, Avi

    2015-01-01

    Despite the high prevalence of singular potential in general, and rectangular potentials in particular, in applied scattering models, to date little is known about their short time effects. The reason is that singular potentials cause a mixture of complicated local as well as non-local effects. The object of this work is to derive a generic method to calculate analytically the short-time impact of any singular potential. In this paper it is shown that the scattering of a smooth wavefunction on a singular potential is totally equivalent, in the short-time regime, to the free propagation of a singular wavefunction. However, the latter problem was totally addressed analytically in Ref. [7]. Therefore, this equivalency can be utilized in solving analytically the short time dynamics of any smooth wavefunction at the presence of a singular potentials. In particular, with this method the short-time dynamics of any problem where a sharp boundaries potential (e.g., a rectangular barrier) is turned on instantaneously can easily be solved analytically

  7. Quality of Standard Reference Materials for Short Time Activation Analysis

    International Nuclear Information System (INIS)

    Ismail, S.S.; Oberleitner, W.

    2003-01-01

    Some environmental reference materials (CFA-1633 b, IAEA-SL-1, SARM-1,BCR-176, Coal-1635, IAEA-SL-3, BCR-146, and SRAM-5) were analysed by short-time activation analysis. The results show that these materials can be classified in three groups, according to their activities after irradiation. The obtained results were compared in order to create a quality index for determination of short-lived nuclides at high count rates. It was found that Cfta is not a suitable standard for determining very short-lived nuclides (half-lives<1 min) because the activity it produces is 15-fold higher than that SL-3. Biological reference materials, such as SRM-1571, SRM-1573, SRM-1575, SRM-1577, IAEA-392, and IAEA-393, were also investigated by a higher counting efficiency system. The quality of this system and its well-type detector for investigating short-lived nuclides was discussed

  8. Stent Coating Integrity of Durable and Biodegradable Coated Drug Eluting Stents.

    Science.gov (United States)

    Yazdani, Saami K; Sheehy, Alexander; Pacetti, Stephen; Rittlemeyer, Brandon; Kolodgie, Frank D; Virmani, Renu

    2016-10-01

    Coatings consisting of a polymer and drug are widely used in drug-eluting stents (DES) and are essential in providing programmable drug release kinetics. Among other factors, stent coating technologies can influence blood compatibility, affect acute and sub-acute healing, and potentially trigger a chronic inflammatory response. The aim of this study was to investigate the short-term (7 and 28 days) and long-term (90 and 180 days) coating integrity of the Xience Prime Everolimus-Eluting Stent (EES), Resolute Zotarolimus-Eluting Stent (ZES), Taxus Paclitaxel-Eluting Stent (PES), and Nobori Biolimus A9-Eluting Stent (BES) in a rabbit ilio-femoral stent model. Stented arteries (n = 48) were harvested and the tissue surrounding the implanted stents digested away with an enzymatic solution. Results demonstrated that the majority of struts of EES were without any coating defects with a few struts showing minor defects. Similarly, for the ZES, most of the struts were without coating defects at all time points except at 180 days. The majority of PES demonstrated mostly webbing and uneven coating. In the BES group, the majority of strut coating showed polymer cracking. Overall, the EES and ZES had fewer coating defects than the PES and BES. Coating defects, however increase over time for the ZES, whereas the percent of coating irregularities remained constant for the EES. These results provide, for the first time, a comparison of the long-term durability of these drug-eluting stent coatings in vivo. © 2016, Wiley Periodicals, Inc.

  9. Short-time quantum propagator and Bohmian trajectories

    Energy Technology Data Exchange (ETDEWEB)

    Gosson, Maurice de, E-mail: maurice.degosson@gmail.com [Universität Wien, Fakultät für Mathematik, NuHAG, Wien 1090 (Austria); Hiley, Basil [University of London, Birkbeck College, Theoretical Physics Unit, London WC1E 7HX (United Kingdom)

    2013-12-06

    We begin by giving correct expressions for the short-time action following the work Makri–Miller. We use these estimates to derive an accurate expression modulo Δt{sup 2} for the quantum propagator and we show that the quantum potential is negligible modulo Δt{sup 2} for a point source, thus justifying an unfortunately largely ignored observation of Holland made twenty years ago. We finally prove that this implies that the quantum motion is classical for very short times.

  10. A short history of fractal-Cantorian space-time

    International Nuclear Information System (INIS)

    Marek-Crnjac, L.

    2009-01-01

    The article attempts to give a short historical overview of the discovery of fractal-Cantorian space-time starting from the 17th century up to the present. In the last 25 years a great number of scientists worked on fractal space-time notably Garnet Ord in Canada, Laurent Nottale in France and Mohamed El Naschie in England who gave an exact mathematical procedure for the derivation of the dimensionality and curvature of fractal space-time fuzzy manifold.

  11. Optimum short-time polynomial regression for signal analysis

    Indian Academy of Sciences (India)

    A Sreenivasa Murthy

    the Proceedings of European Signal Processing Conference. (EUSIPCO) 2008. ... In a seminal paper, Savitzky and Golay [4] showed that short-time polynomial modeling is ...... We next consider a linearly frequency-modulated chirp with an exponentially .... 1 http://www.physionet.org/physiotools/matlab/ECGwaveGen/.

  12. Analysis of co-eluted isomers of high-molecular weight polycyclic aromatic hydrocarbons in high performance liquid chromatography fractions via solid-phase nanoextraction and time-resolved Shpol'skii spectroscopy.

    Science.gov (United States)

    Wilson, Walter B; Campiglia, Andres D

    2011-09-28

    We present an accurate method for the determination of isomers of high-molecular weight polycyclic aromatic hydrocarbons co-eluted in HPLC fractions. The feasibility of this approach is demonstrated with two isomers of molecular weight 302 with identical mass fragmentation patterns, namely dibenzo[a,i]pyrene and naphtho[2,3-a]pyrene. Qualitative and quantitative analysis is carried out via laser-excited time-resolved Shpol'skii spectroscopy at liquid helium temperature. Unambiguous identification of co-eluted isomers is based on their characteristic 4.2 K line-narrowed spectra in n-octane as well as their fluorescence lifetimes. Pre-concentration of HPLC fractions prior to spectroscopic analysis is performed with the aid of gold nanoparticles via an environmentally friendly procedure. In addition to the two co-eluted isomers, the analytical figures of merit of the entire procedure were evaluated with dibenzo[a,l]pyrene, dibenzo[a,h]pyrene and dibenzo[a,e]pyrene. The analytical recoveries from drinking water samples varied between 98.2±5.5 (dibenzo[a,l]pyrene) and 102.7±3.2% (dibenzo[a,i]pyrene). The limits of detection ranged from 51.1 ng L(-1) (naphtho[2,3-a]pyrene) to 154 ng L(-1) (dibenzo[a,e]pyrene). The excellent analytical figures of merit associated to its HPLC compatibility makes this approach an attractive alternative for the analysis of co-eluted isomers with identical mass spectra. Copyright © 2011 Elsevier B.V. All rights reserved.

  13. X-ray testing for short-time dynamic applications

    International Nuclear Information System (INIS)

    Kurfiss, Malte; Moser, Stefan; Popko, Gregor; Nau, Siegfried

    2017-01-01

    For nondestructive testing purposes new challenges are short-time dynamic processes. The application of x-ray flash tubes and modern high-speed cameras allows the observation of the opening of air-bags or the energy absorption of compressed tubes as occurring during a vehicle crash. Special algorithms designed for computerized tomography analyses allow the 3D reconstruction at individual time points of the dynamic process. Possibilities and limitations of the actual techniques are discussed.

  14. The case of escape probability as linear in short time

    Science.gov (United States)

    Marchewka, A.; Schuss, Z.

    2018-02-01

    We derive rigorously the short-time escape probability of a quantum particle from its compactly supported initial state, which has a discontinuous derivative at the boundary of the support. We show that this probability is linear in time, which seems to be a new result. The novelty of our calculation is the inclusion of the boundary layer of the propagated wave function formed outside the initial support. This result has applications to the decay law of the particle, to the Zeno behaviour, quantum absorption, time of arrival, quantum measurements, and more.

  15. Short Sleep Times Predict Obesity in Internal Medicine Clinic Patients

    Science.gov (United States)

    Buscemi, Dolores; Kumar, Ashwani; Nugent, Rebecca; Nugent, Kenneth

    2007-01-01

    Study Objectives: Epidemiological studies have demonstrated an association between short sleep times and obesity as defined by body mass index (BMI). We wanted to determine whether this association occurs in patients with chronic medical diagnoses since the number of confounding factors is likely higher in patients than the general population. Methods: Two hundred patients attending internal medicine clinics completed a survey regarding sleep habits, lifestyle characteristics, and medical diagnoses. An independent surveyor collected the information on the questionnaires and reviewed the medical records. Height and weight were measured by clinic personnel. Data were analyzed with multivariate logistic regression. Results: Subjects with short sleep times (< 7 hours) had an increased likelihood of obesity as defined by a BMI ≥ 30 kg/m2 when compared to the reference group of (8, 9] hours (odds ratio 2.93; 95% confidence interval, 1.06–8.09). There was a U-shaped relationship between obesity and sleep time in women but not in men. Young age (18 to 49 years), not smoking, drinking alcohol, hypertension, diabetes, and sleep apnea were also associated with obesity in the overall model. Conclusions: This study demonstrates an association between short sleep times and obesity in undifferentiated patients attending an internal medicine clinic using models adjusting for age, lifestyle characteristics, and some medical diagnoses. The U-shaped relationship in women suggests that sleep patterns may have gender specific associations. These observations provide the background for therapeutic trials in weight loss in patients with established medical problems. Citation: Buscemi D; Kumar A; Nugent R; Nugent K. Short sleep times predict obesity in internal medicine clinic patients. J Clin Sleep Med 2007;3(7):681–688. PMID:18198800

  16. Short echo time, fast gradient-echo imaging

    International Nuclear Information System (INIS)

    Haacke, E.M.; Lenz, G.W.

    1987-01-01

    Present fast-gradient-echoes schemes can acquire volume data rapidly and are flexible in T1 or T1/T2 contrast behavior. However, sequences used to date employ echo time (TE) values of about 15 ms +- 5 and, because of in vivo field inhomogeneities (short T2), they suffer badly from signal loss near sinuses and tissue boundaries. The authors implemented sequences with TE = 4-6 ms and found significant improvement in image quality, especially at high fields. Examples with long TEs vs. short TEs are given in the knee, spine, head, and orbits. Further advantages include (1) faster repetition times (15 ms), (2) higher-quality spin-density or T1-weighted images, and (3) reduction of blood motion artifacts

  17. Production of 99Tc generators with automatic elution

    International Nuclear Information System (INIS)

    Mengatti, J.; Yanagawa, S.T.I.; Mazzarro, E.; Gasiglia, H.T.; Rela, P.R.; Silva, C.P.G. da; Pereira, N.P.S. de.

    1983-10-01

    The improvements performed on the routine production of sup(99m) Tc-generators at the Instituto de Pesquisas Energeticas e Nucleares-CNEN/SP, are described. The old model generators (manual elution of sup(99m) Tc) were substituted by automatically eluted generators (Vacuum system). The alumina column, elution system and acessories were modified; the elution time was reduced from 60 to 20-30 seconds. The new generators give 80-90% elution yields using six mililiters of sodium chloride 0,9% as sup(99m) Tc eluant instead of the 10 mililiters necessary to eluate the old generators. So, the radioactive concentrations are now 70% higher. The radioactive, radiochemical, chemical and microbiological criteria were examinated for sup(99m) Tc solutions. Like old generators, automatic generators were considered safe for medical purpose. (Author) [pt

  18. Optimization of the elution buffer and concentration method for detecting hepatitis E virus in swine liver using a nested reverse transcription-polymerase chain reaction and real-time reverse transcription-polymerase chain reaction.

    Science.gov (United States)

    Son, Na Ry; Seo, Dong Joo; Lee, Min Hwa; Seo, Sheungwoo; Wang, Xiaoyu; Lee, Bog-Hieu; Lee, Jeong-Su; Joo, In-Sun; Hwang, In-Gyun; Choi, Changsun

    2014-09-01

    The aim of this study was to develop an optimal technique for detecting hepatitis E virus (HEV) in swine livers. Here, three elution buffers and two concentration methods were compared with respect to enhancing recovery of HEV from swine liver samples. Real-time reverse transcription-polymerase chain reaction (RT-PCR) and nested RT-PCR were performed to detect HEV RNA. When phosphate-buffered saline (PBS, pH 7.4) was used to concentrate HEV in swine liver samples using ultrafiltration, real-time RT-PCR detected HEV in 6 of the 26 samples. When threonine buffer was used to concentrate HEV using polyethylene glycol (PEG) precipitation and ultrafiltration, real-time RT-PCR detected HEV in 1 and 3 of the 26 samples, respectively. When glycine buffer was used to concentrate HEV using ultrafiltration and PEG precipitation, real-time RT-PCR detected HEV in 1 and 3 samples of the 26 samples, respectively. When nested RT-PCR was used to detect HEV, all samples tested negative regardless of the type of elution buffer or concentration method used. Therefore, the combination of real-time RT-PCR and ultrafiltration with PBS buffer was the most sensitive and reliable method for detecting HEV in swine livers. Copyright © 2014 Elsevier B.V. All rights reserved.

  19. Absence of gender disparity in short-term clinical outcomes in patients with acute ST-segment elevation myocardial infarction undergoing sirolimus-eluting stent based primary coronary intervention: a report from Shanghai Acute Coronary Event (SACE) Registry.

    Science.gov (United States)

    Zhang, Qi; Qiu, Jian-Ping; Zhang, Rui-Yan; Li, Yi-Gang; He, Ben; Jin, Hui-Gen; Zhang, Jun-Feng; Wang, Xiao-Long; Jiang, Li; Liao, Min-Lei; Hu, Jian; Shen, Wei-Feng

    2010-04-05

    Randomized, controlled trials have demonstrated the superiority of sirolimus-eluting stent (SES) implantation during primary percutaneous coronary intervention (PCI), as opposed to bare-metal stents, in patients with ST-elevation myocardial infarction (STEMI). This study aimed to test the hypothesis that clinical benefits of SES treatment were independent of gender in this setting. A total of 2042 patients with STEMI undergoing SES-based primary PCI were prospectively enrolled into Shanghai Acute Coronary Event (SACE) registry (1574 men and 468 women). Baseline demographics, angiographic and PCI features, and in-hospital and 30-day major adverse cardiac events (MACE) were analyzed as a function of gender. Compared with men, women were older and more frequently had hypertension, diabetes, and hypercholesterolemia. Use of platelet glycoprotein IIb/IIIa receptor inhibitor (GPI, 65.5% vs. 62.2%, P = 0.10) and procedural success rate (95.0% vs. 94.2%, P = 0.52) were similar in both genders. In-hospital death and MACE occurred in 3.8% and 7.6%, and 4.5% and 8.1% in the male and female patients, respectively (all P > 0.05). At 30-day follow-up, survival (94.3% vs. 93.8%, P = 0.66) and MACE-free survival (90.2% vs. 89.3%, P = 0.52) did not significantly differ between men and women. After adjustment for differences in patient demographics, angiographic and procedural features, there were no significant difference in either in-hospital (OR = 0.77, 95%CI of 0.48 to 1.22, P = 0.30) or 30-day mortality (OR = 1.28, 95%CI of 0.73 to 2.23, P = 0.38) between women and men. Despite more advanced age and clustering of risk factors in women, female patients with STEMI treated by SES-based primary PCI had similar in-hospital and short-term clinical outcomes as their male counterparts.

  20. The short time Fourier transform and local signals

    Science.gov (United States)

    Okumura, Shuhei

    In this thesis, I examine the theoretical properties of the short time discrete Fourier transform (STFT). The STFT is obtained by applying the Fourier transform by a fixed-sized, moving window to input series. We move the window by one time point at a time, so we have overlapping windows. I present several theoretical properties of the STFT, applied to various types of complex-valued, univariate time series inputs, and their outputs in closed forms. In particular, just like the discrete Fourier transform, the STFT's modulus time series takes large positive values when the input is a periodic signal. One main point is that a white noise time series input results in the STFT output being a complex-valued stationary time series and we can derive the time and time-frequency dependency structure such as the cross-covariance functions. Our primary focus is the detection of local periodic signals. I present a method to detect local signals by computing the probability that the squared modulus STFT time series has consecutive large values exceeding some threshold after one exceeding observation following one observation less than the threshold. We discuss a method to reduce the computation of such probabilities by the Box-Cox transformation and the delta method, and show that it works well in comparison to the Monte Carlo simulation method.

  1. Short and long-term safety and efficacy of polymer-free vs. durable polymer drug-eluting stents. A comprehensive meta-analysis of randomized trials including 6178 patients

    NARCIS (Netherlands)

    Navarese, E.P.; Kowalewski, M.; Cortese, B.; Kandzari, D.; Dias, S.; Wojakowski, W.; Buffon, A.; Lansky, A.; Angelini, P.; Torguson, R.; Kubica, J.; Kelm, M.; Boer, M.J. de; Waksman, R.; Suryapranata, H.

    2014-01-01

    BACKGROUND: The efficacy and safety of polymer-free drug-eluting stents (DESs) in clinical practice is currently subject of debate; randomized trials (RCTs) conducted so far provided conflicting results or were underpowered to definitively address this question; we aimed to investigate the efficacy

  2. Evaluation of scaling invariance embedded in short time series.

    Directory of Open Access Journals (Sweden)

    Xue Pan

    Full Text Available Scaling invariance of time series has been making great contributions in diverse research fields. But how to evaluate scaling exponent from a real-world series is still an open problem. Finite length of time series may induce unacceptable fluctuation and bias to statistical quantities and consequent invalidation of currently used standard methods. In this paper a new concept called correlation-dependent balanced estimation of diffusion entropy is developed to evaluate scale-invariance in very short time series with length ~10(2. Calculations with specified Hurst exponent values of 0.2,0.3,...,0.9 show that by using the standard central moving average de-trending procedure this method can evaluate the scaling exponents for short time series with ignorable bias (≤0.03 and sharp confidential interval (standard deviation ≤0.05. Considering the stride series from ten volunteers along an approximate oval path of a specified length, we observe that though the averages and deviations of scaling exponents are close, their evolutionary behaviors display rich patterns. It has potential use in analyzing physiological signals, detecting early warning signals, and so on. As an emphasis, the our core contribution is that by means of the proposed method one can estimate precisely shannon entropy from limited records.

  3. Evaluation of scaling invariance embedded in short time series.

    Science.gov (United States)

    Pan, Xue; Hou, Lei; Stephen, Mutua; Yang, Huijie; Zhu, Chenping

    2014-01-01

    Scaling invariance of time series has been making great contributions in diverse research fields. But how to evaluate scaling exponent from a real-world series is still an open problem. Finite length of time series may induce unacceptable fluctuation and bias to statistical quantities and consequent invalidation of currently used standard methods. In this paper a new concept called correlation-dependent balanced estimation of diffusion entropy is developed to evaluate scale-invariance in very short time series with length ~10(2). Calculations with specified Hurst exponent values of 0.2,0.3,...,0.9 show that by using the standard central moving average de-trending procedure this method can evaluate the scaling exponents for short time series with ignorable bias (≤0.03) and sharp confidential interval (standard deviation ≤0.05). Considering the stride series from ten volunteers along an approximate oval path of a specified length, we observe that though the averages and deviations of scaling exponents are close, their evolutionary behaviors display rich patterns. It has potential use in analyzing physiological signals, detecting early warning signals, and so on. As an emphasis, the our core contribution is that by means of the proposed method one can estimate precisely shannon entropy from limited records.

  4. Application of short-time activation analysis in the sciences

    International Nuclear Information System (INIS)

    Grass, F.

    1991-01-01

    Short-time activation analysis has proved to be a valuable tool in nearly all fields of science. To take full advantage of this technique, it is favorable to use a fast transfer system and a high resolution high rate gamma-spectroscopy system for short lived gamma-emitters and a Cherenkov detector for the determination of hard beta-emitters. It is then possible to utilize sub-minute nuclides Li-8 (740 ms), B-12 (20 ms), F-20 (11.1 s), Y-89m (16 s), and Pb-207m (800 ms) for the determination of these elements. Besides these sub-minute nuclides which constitute the only possibility for neutron activation analysis of these elements there are a number of other elements which form longer lived nuclides on short irradiation. The analysis of the halogenides F, Cl, Br, I in waste water of a sewage incineration plant can be achieved with a single 20 s irradiation and two consecutive measurement of 20 and 600 s using Cl-38m, F-20, Br-79m as well as the longer lived Cl-38, Br-80, I-128

  5. Short-time perturbation theory and nonrelativistic duality

    International Nuclear Information System (INIS)

    Whitenton, J.B.; Durand, B.; Durand, L.

    1983-01-01

    We give a simple proof of the nonrelativistic duality relation 2 sigma/sub bound/>roughly-equal 2 sigma/sub free/> for appropriate energy averages of the cross sections for e + e - →(qq-bar bound states) and e + e - →(free qq-bar pair), and calculate the corrections to the relation by relating W 2 sigma to the Fourier transform of the Feynman propagation function and developing a short-time perturbation series for that function. We illustrate our results in detail for simple power-law potentials and potentials which involve combinations of powers

  6. Directional short-time Fourier transform of distributions

    Directory of Open Access Journals (Sweden)

    Katerina Hadzi-Velkova Saneva

    2016-04-01

    Full Text Available Abstract In this paper we consider the directional short-time Fourier transform (DSTFT that was introduced and investigated in (Giv in J. Math. Anal. Appl. 399:100-107, 2013. We analyze the DSTFT and its transpose on test function spaces S ( R n $\\mathcal {S}(\\mathbb {R}^{n}$ and S ( Y 2 n $\\mathcal {S}(\\mathbb {Y}^{2n}$ , respectively, and prove the continuity theorems on these spaces. Then the obtained results are used to extend the DSTFT to spaces of distributions.

  7. EVOLVING TO TYPE Ia SUPERNOVAE WITH SHORT DELAY TIMES

    International Nuclear Information System (INIS)

    Wang Bo; Chen Xuefei; Han Zhanwen; Meng Xiangcun

    2009-01-01

    The single-degenerate model is currently a favorable progenitor model for Type Ia supernovae (SNe Ia). Recent investigations on the white dwarf (WD) + He star channel of the single-degenerate model imply that this channel is noteworthy for producing SNe Ia. In this paper, we studied SN Ia birthrates and delay times of this channel via a detailed binary population synthesis approach. We found that the Galactic SN Ia birthrate from the WD + He star channel is ∼0.3 x 10 -3 yr -1 according to our standard model, and that this channel can explain SNe Ia with short delay times (∼4.5 x 10 7 -1.4 x 10 8 yr). Meanwhile, these WD + He star systems may be related to the young supersoft X-ray sources prior to SN Ia explosions.

  8. Decision time horizon for music genre classification using short time features

    DEFF Research Database (Denmark)

    Ahrendt, Peter; Meng, Anders; Larsen, Jan

    2004-01-01

    In this paper music genre classification has been explored with special emphasis on the decision time horizon and ranking of tapped-delay-line short-time features. Late information fusion as e.g. majority voting is compared with techniques of early information fusion such as dynamic PCA (DPCA......). The most frequently suggested features in the literature were employed including mel-frequency cepstral coefficients (MFCC), linear prediction coefficients (LPC), zero-crossing rate (ZCR), and MPEG-7 features. To rank the importance of the short time features consensus sensitivity analysis is applied...

  9. Hepatic Arterial Chemoembolization Using Drug-Eluting Beads in Gastrointestinal Neuroendocrine Tumor Metastatic to the Liver

    International Nuclear Information System (INIS)

    Gaur, Shantanu K.; Friese, Jeremy L.; Sadow, Cheryl A.; Ayyagari, Rajasekhara; Binkert, Christoph A.; Schenker, Matthew P.; Kulke, Matthew; Baum, Richard

    2011-01-01

    Purpose: This study was designed to evaluate short ( 3 months) follow-up in patients with metastatic neuroendocrine tumor to the liver who underwent hepatic arterial chemoembolization with drug-eluting beads at a single institution. Methods: Institutional review board approval was obtained for this retrospective review. All patients who were treated with 100–300 or 300–500 μm drug-eluting LC Beads (Biocompatibles, UK) preloaded with doxorubicin (range, 50–100 mg) for GI neuroendocrine tumor metastatic to the liver from June 2004 to June 2009 were included. CT and MRI were evaluated for progression using Response Evaluation Criteria In Solid Tumors (RECIST) or European Association for the Study of the Liver (EASL) criteria. Short-term ( 3 months) imaging response was determined and Kaplan–Meier survival curves were plotted. Results: Thirty-eight drug-eluting bead chemoembolization procedures were performed on 32 hepatic lobes, comprising 21 treatment cycles in 18 patients. All procedures were technically successful with two major complications (biliary injuries). At short-term follow-up (<3 months), 22 of 38 (58%) procedures and 10 of 21 (48%) treatment cycles produced an objective response (OR) with the remainder having stable disease (SD). At intermediate-term follow-up (mean, 445 days; range, 163–1247), 17 of 26 (65%) procedures and 8 of 14 (57%) treatment cycles produced an OR. Probability of progressing was approximately 52% at 1 year with a median time to progression of 419 days. Conclusions: Drug-eluting bead chemoembolization is a reasonable alternative to hepatic arterial embolization and chemoembolization for the treatment of metastatic neuroendocrine tumor to the liver.

  10. THE BEHAVIOR OF SOLUBLE METALS ELUTED FROM Ni/Fe-BASED ALLOY REACTORS AFTER HIGH-TEMPERATURE AND HIGH-PRESSURE WATER PROCESS

    Directory of Open Access Journals (Sweden)

    M. Faisal

    2012-05-01

    Full Text Available The behavior of heavy metals eluted from the wall of Ni/Fe-based alloy reactors after high-temperature and high-pressure water reaction were studied at temperatures ranging from 250 to 400oC. For this purpose, water and cysteic acid were heated in two reactor materials which are SUS 316 and Inconel 625. Under the tested conditions, the erratic behaviors of soluble metals eluted from the wall of Ni/Fe-based alloy in high temperature water were observed. Results showed that metals could be eluted even at a short contact time. The presence of air also promotes elution at sub-critical conditions. At sub-critical conditions, a significant amount of Cr was extracted from SUS 316, while only traces of Ni, Fe, Mo and Mn were eluted. In contrast, Ni was removed in significant amounts compared to Cr when Inconel 625 was tested. It was observed that eluted metals tend to increased under acidic conditions and most of those metals were over the limit of WHO guideline for drinking water. The results are significant both on the viewpoint of environmental regulation on disposal of wastes containing heavy metals, toxicity of resulting product and catalytic effect on a particular reaction.

  11. Elution of Monomers from Provisional Composite Materials

    Directory of Open Access Journals (Sweden)

    Simon Daniel Schulz

    2015-01-01

    Full Text Available The aim of this study was to evaluate the elution of substances from different materials used for the manufacturing of temporary indirect restorations, after storage in saliva and ethanol 75%. 10 samples of three chemically cured materials (Protemp 3 Garant, Systemp.c&b, and Trim and one light-cured material (Clip F were stored in saliva and ethanol 75% for 24 h, 7, and days 28 days. From the storage media at each time period, samples were prepared and analysed by LC-MS/MS, in order to access the elution of monomers. The results differed among the materials (P ≤ 0.05. No monomers were detected in the samples of Protemp 3 Garant and Clip F. Substances were detected only in ethanol samples of Systemp.c&b and Trim. The amount of BisGMA, TEGDMA, and UDMA 2 released from Systemp.c&b was higher compared to Trim. Storage time affected the release of substances (P ≤ 0.05. The highest release was observed within the first 24 h. It can be concluded that provisional resin composite materials do not show high release of monomers and this release is material dependent. However, the detection of additional peaks during the analysis, suggesting the formation of by-products of the eluted substances, may not be in favour of these materials with respect to their toxicity.

  12. Short-time action electric generators to power physical devices

    International Nuclear Information System (INIS)

    Glebov, I.A.; Kasharskij, Eh.G.; Rutberg, F.G.; Khutoretskij, G.M.

    1982-01-01

    Requirements to be met by power-supply sources of the native electrophysical facilities have been analyzed and trends in designing foreign electric machine units of short-time action have been considered. Specifications of a generator, manufactured in the form of synchronous bipolar turbogenerator with an all-forged rotor with indirect air cooling of the rotor and stator windings are presented. Front parts of the stator winding are additionally fixed using glass-textolite rings, brackets and gaskets. A flywheel, manufactured in the form of all-forged steel cylinder is joined directly with the generator rotor by means of a half-coupling. An acceleration asynchronous engine with a phase rotor of 4 MW nominal capacity is located on the opposite side of the flywheel. The generator peak power is 242 MVxA; power factor = 0.9; energy transferred to the load 5per 1 pulse =00 MJ; the flywheel weight 81 t

  13. Forecast model of landslides in a short time

    International Nuclear Information System (INIS)

    Sanchez Lopez, Reinaldo

    2006-01-01

    The IDEAM in development of their functions as member of the national technical committee for the prevention and disasters attention (SNPAD) accomplishes the follow-up, monitoring and forecast in real time of the environmental dynamics that in extreme situations constitute threats and natural risks. One of the frequent dynamics and of greater impact is related to landslides, those that affect persistently the life of the persons, the infrastructure, the socioeconomic activities and the balance of the environment. The landslide in Colombia and in the world are caused mainly by effects of the rain, due to that, IDEAM has come developing forecast model, as an instrument for risk management in a short time. This article presents aspects related to their structure, operation, temporary space resolution, products, results, achievements and projections of the model. Conceptually, the model is support by the principle of the dynamic temporary - space, of the processes that consolidate natural hazards, particularly in areas where the man has come building the risk. Structurally, the model is composed by two sub-models; the general susceptibility of the earthly model and the critical rain model as a denotative factor, that consolidate the hazard process. In real time, the model, works as a GIS, permitting the automatic zoning of the landslides hazard for issue public advisory warming to help makers decisions on the risk that cause frequently these events, in the country

  14. Nonequilibrium Physics at Short Time Scales: Formation of Correlations

    International Nuclear Information System (INIS)

    Peliti, L

    2005-01-01

    It is a happy situation when similar concepts and theoretical techniques can be applied to widely different physical systems because of a deep similarity in the situations being studied. The book illustrates this well; it focuses on the description of correlations in quantum systems out of equilibrium at very short time scales, prompted by experiments with short laser pulses in semiconductors, and in complex reactions in heavy nuclei. In both cases the experiments are characterized by nonlinear dynamics and by strong correlations out of equilibrium. In some systems there are also important finite-size effects. The book comprises several independent contributions of moderate length, and I sometimes felt that a more intensive effort in cross-coordination of the different contributions could have been of help. It is divided almost equally between theory and experiment. In the theoretical part, there is a thorough discussion both of the kinematic aspects (description of correlations) and the dynamical ones (evaluation of correlations). The experimental part is naturally divided according to the nature of the system: the interaction of pulsed lasers with matter on the one hand, and the correlations in finite-size systems (nanoparticles and nuclei) on the other. There is also a discussion on the dynamics of superconductors, a subject currently of great interest. Although an effort has been made to keep each contribution self-contained, I must admit that reading level is uneven. However, there are a number of thorough and stimulating contributions that make this book a useful introduction to the topic at the level of graduate students or researchers acquainted with quantum statistical mechanics. (book review)

  15. The effect of short-time active listening training.

    Science.gov (United States)

    Tatsumi, Asami; Sumiyoshi, Kenichi; Kawaguchi, Hitomi; Sano, Yukiko

    2010-01-01

    We conducted mental health training incorporating active listening for managers at a site of a general chemical company with 1,400 employees. Our purpose was to clarify the effect of active listening training of 2.5h. All subjects were managers. The mental health training was given to 229 managers, 21 times from May 2007 until March 2008. Surveys were conducted from May 2007 to September 2008. The training sessions were conducted in a company meeting room, starting at 2:00 p.m. The importance and significance of listening as a mental health measure and methods of active listening were explained in the training. Afterward, role-playing and follow-up discussions were done twice each. In summaries, participants wrote down what they noticed about listening and gave group presentations. The instructor commented on the presentations, and ended the session by passing out and explaining a paper summarizing what is important in listening. The training was evaluated with a questionnaire distributed at the completion of training, and questionnaires on implementation of what was learned were distributed 1, 3, and 6 mo later. The Active Listening Attitude Scale (ALAS; composed of two scales for method of listening and listening attitude) developed by Mishima et al. was also used before and 1, 3, and 6 mo after the training. In questionnaires distributed on the same day after training, 60% of the 212 respondents said the training time was just right, and 30.1% felt it was too short. The difficulty level of the training was considered appropriate by 77.8%, and 79.7% intended to implement what they had learned. Overall satisfaction was high at 85.9%. In the questionnaire 6 mo after training, 81.4% of the 145 respondents remembered the content of the training and 49.7% said they were practicing what they had learned. They responded that their conversations with subordinates about non-work topics had increased, and communication and support at work had become smoother. ALAS was

  16. Innovation: study of 'ultra-short' time reactions

    International Nuclear Information System (INIS)

    Anon.

    2001-01-01

    This short article presents the new Elyse facility of Orsay-Paris 11 university for the study of ultra-short chemical and biochemical phenomena. Elyse uses the 'pump-probe' technique which consists in two perfectly synchronized electron and photon pulses. It comprises a 3 to 9 MeV electron accelerator with a HF gun photo-triggered with a laser. Elyse can initiate reactions using ultra-short electron pulses (radiolysis) or ultra-short photon pulses (photolysis). (J.S.)

  17. Job quality of short-time workers and perception and support from their managers

    OpenAIRE

    坂爪, 洋美

    2017-01-01

    The purpose of this study was to clarify the relationship between the characteristics of job quality that short-time workers occupied and the managers’ perception and support whose member has used short-time working hour system. A total of 559 first-line managers who has a member using short-time working hour system completed a web-based survey assessing job quality of short-time workers , the risk of using short-timeworking hour system, career perspective of short-time workers, and the suppo...

  18. Mechanistic models for cancer development after short time radiation exposure

    International Nuclear Information System (INIS)

    Kottbauer, M. M.

    1997-12-01

    In this work two biological based models were developed. First the single-hit model for solid tumors (SHM-S) and second the single-hit model for leukemia (SHM-L). These models are a further development of the Armitage-Doll model for the special case of a short time radiation exposure. The basis of the models is the multistage process of carcinogeneses. The single-hit models provide simultaneously the age-dependent cancer-rate of spontaneous and radiation induced tumors as well as the dose-effect relationships at any age after exposure. The SHM-S leads to a biological based dose-effect relationship, which is similar to the relative risk model suggested by the ICRP 60. The SHM-S describes the increased mortality rate of the bomb survivors more accurate than the relative risk model. The SHM-L results in an additive dose-effect relationship. It is shown that only small differences in the derivation of the two models lead to the two dose-effect relationships. Beside the radiation exposure the new models consider the decrease of the cancer mortality rate at higher ages (age>75) which can be traced back mainly to three causes: competitive causes of death, reduction of cell proliferation and reduction of risk groups. The single-hit models also consider children cancer, the different rates of incidence and mortality, influence of the immune system and the cell-killing effect. (author)

  19. Short-time home coming project in evacuation zone

    International Nuclear Information System (INIS)

    Tatsuzaki, Hideo

    2011-01-01

    Accident at Fukushima Daiichi Nuclear Power Plants (NPPs) forced neighboring residents to evacuate, and evacuation zone (20 km radius from NPPs) was defined as highly contaminated and designated as no-entry zones. Residents had been obliged to live a refugee life for a longer period than expected. Short-time home coming project was initiated according to their requests. They came to the meeting place called transfer place (20 - 30 km radius from NPPs), wore protective clothing and personal dosimeter with having drinking water and came home in evacuation zone with staffs by bus. Their healthcare management professionals were fully prepared for emergency. After collecting necessary articles at home within two hours, they returned to the meeting place by bus for screening and dressing, and went back to refuge house. If screening data were greater than 13 kcpm using GM counters, partial body decontamination had been conducted by wiping and if greater than 100 kcpm, whole body decontamination was requested but not conducted. Dose rate of residents and staffs was controlled less than 1 mSv, which was alarm level of personal dosimeter. Stable iodine was prepared but actually not used. (T. Tanaka)

  20. Probabilistic eruption forecasting at short and long time scales

    Science.gov (United States)

    Marzocchi, Warner; Bebbington, Mark S.

    2012-10-01

    Any effective volcanic risk mitigation strategy requires a scientific assessment of the future evolution of a volcanic system and its eruptive behavior. Some consider the onus should be on volcanologists to provide simple but emphatic deterministic forecasts. This traditional way of thinking, however, does not deal with the implications of inherent uncertainties, both aleatoric and epistemic, that are inevitably present in observations, monitoring data, and interpretation of any natural system. In contrast to deterministic predictions, probabilistic eruption forecasting attempts to quantify these inherent uncertainties utilizing all available information to the extent that it can be relied upon and is informative. As with many other natural hazards, probabilistic eruption forecasting is becoming established as the primary scientific basis for planning rational risk mitigation actions: at short-term (hours to weeks or months), it allows decision-makers to prioritize actions in a crisis; and at long-term (years to decades), it is the basic component for land use and emergency planning. Probabilistic eruption forecasting consists of estimating the probability of an eruption event and where it sits in a complex multidimensional time-space-magnitude framework. In this review, we discuss the key developments and features of models that have been used to address the problem.

  1. How much DNA is lost? Measuring DNA loss of short-tandem-repeat length fragments targeted by the PowerPlex 16® system using the Qiagen MinElute Purification Kit.

    Science.gov (United States)

    Kemp, Brian M; Winters, Misa; Monroe, Cara; Barta, Jodi Lynn

    2014-01-01

    The success in recovering genetic profiles from aged and degraded biological samples is diminished by fundamental aspects of DNA extraction, as well as its long-term preservation, that are not well understood. While numerous studies have been conducted to determine whether one extraction method was superior to others, nearly all of them were initiated with no knowledge of the actual starting DNA quantity in the samples prior to extraction, so they ultimately compared the outcome of all methods relative to the best. Using quantitative PCR to estimate the copy count of synthetic standards before (i.e., "copies in") and after (i.e., "copies out") purification by the Qiagen MinElute PCR Purification Kit, we documented DNA loss within a pool of 16 different-sized fragments ranging from 106 to 409 bp in length, corresponding to those targeted by the PowerPlex 16 System (Promega, Madison, WI). Across all standards from 10(4) to 10(7) copies/μL, loss averaged between 21.75% and 60.56% (mean, 39.03%), which is not congruent with Qiagen's claim that 80% of 70 bp to 4 kb fragments are retained using this product (i.e., 20% loss). Our study also found no clear relationship either between DNA strand length and retention or between starting copy number and retention. This suggests that there is no molecule bias across the MinElute column membrane and highlights the need for manufacturers to clearly and accurately describe on what their claims are based, and should also encourage researchers to document DNA retention efficiencies of their own methods and protocols. Understanding how and where to reduce loss of molecules during extraction and purification will serve to generate clearer and more accurate data, which will enhance the utility of ancient and low-copy-number DNA as a tool for closing forensic cases or in reconstructing the evolutionary history of humans and other organisms.

  2. The Indicating FTA Elute Cartridge

    Science.gov (United States)

    de Bie, Roosmarie P.; Schmeink, Channa E.; Bakkers, Judith M.J.E.; Snijders, Peter J.F.; Quint, Wim G.V.; Massuger, Leon F.A.G.; Bekkers, Ruud L.M.; Melchers, Willem J.G.

    2011-01-01

    The clinically validated high-risk human papillomavirus (hrHPV) Hybrid Capture 2 (HC2) and GP5+/6+-PCR assays were analyzed on an Indicating FTA Elute cartridge (FTA cartridge). The FTA cartridge is a solid dry carrier that allows safe transport of cervical samples. FTA cartridge samples were compared with liquid-based samples for hrHPV and high-grade cervical intraepithelial neoplasia (CIN) detection. One cervical sample was collected in a liquid-based medium, and one was applied to the FTA cartridge. DNA was eluted directly from the FTA cartridge by a simple elution step. HC2 and GP5+/6+-PCR assays were performed on both the liquid-based and the FTA-eluted DNA of 88 women. Overall agreement between FTA and liquid-based samples for the presence of hrHPV was 90.9% with GP5+/6+-PCR and 77.3% with HC2. The sensitivity for high-grade CIN of hrHPV testing on the FTA cartridges was 84.6% with GP5+/6+-PCR and only 53.8% with HC2. By comparison, these sensitivities on liquid-based samples were 92.3% and 100% for GP5+/6+-PCR and HC2, respectively. Therefore, the FTA cartridge shows reasonably good overall agreement for hrHPV detection with liquid-based media when using GP5+/6+-PCR but not HC2 testing. Even with GP5+/6+-PCR, the FTA cartridge is not yet capable of detecting all high-grade CIN lesions. PMID:21704269

  3. On the Option Effects of Short-Time Work Arrangements

    NARCIS (Netherlands)

    Huisman, Kuno; Thijssen, J.J.J.

    2018-01-01

    We analyse the short term work (STW) regulations that several OECD countries introduced after the 2007 financial crisis. We view these measures as a collection of real options and study the dynamic effect of STW on the endogenous liquidation decision of the firm. While STW delays a firm’s

  4. Short (

    NARCIS (Netherlands)

    Telleman, Gerdien; den Hartog, Laurens

    2013-01-01

    Aim: This systematic review assessed the implant survival rate of short (<10 mm) dental implants installed in partially edentulous patients. A case report of a short implant in the posterior region have been added. Materials and methods: A search was conducted in the electronic databases of MEDLINE

  5. A time-to-amplitude converter with constant fraction timing discriminators for short time interval measurements

    International Nuclear Information System (INIS)

    Kostamovaara, J.; Myllylae, R.

    1985-01-01

    The construction and the performance of a time-to-amplitude converter equipped with constant fraction discriminators is described. The TAC consists of digital and analog parts which are constructed on two printed circuit boards, both of which are located in a single width NIM module. The dead time of the TAC for a start pulse which is not followed by a stop pulse within the time range of the device (proportional100 ns) is only proportional100 ns, which enables one to avoid counting rate saturation even with a high random input signal rate. The differential and integral nonlinearities of the TAC are better than +-1.5% and 0.05%, respectively. The resolution for input timing pulses of constant shape is 20 ps (fwhm), and less than 10 ps (fwhm) with a modification in the digital part. The walk error of the constant fraction timing discriminators is presented and various parameters affecting it are discussed. The effect of the various disturbances in linearity caused by the fast ECL logic and their minimization are also discussed. The time-to-amplitude converter has been used in positron lifetime studies and for laser range finding. (orig.)

  6. Evaluation of the short- and long-term safety and therapy outcomes of the everolimus-eluting bioresorbable vascular scaffold system in patients with coronary artery stenosis: Rationale and design of the German–Austrian ABSORB RegIstRy (GABI-R)

    Energy Technology Data Exchange (ETDEWEB)

    Nef, Holger, E-mail: holger.nef@innere.med.uni-giessen.de [University of Giessen, Medizinische Klinik I, Department of Cardiology, Giessen (Germany); Wiebe, Jens [University of Giessen, Medizinische Klinik I, Department of Cardiology, Giessen (Germany); Achenbach, Stefan [University of Erlangen, Medizinische Klinik II, Department of Cardiology, Erlangen (Germany); Münzel, Thomas [Department of Medicine II, University Medical Center, Johannes Gutenberg University Mainz, Mainz (Germany); Naber, Christoph [Klinik für Kardiologie und Angiologie, Elisabeth-Krankenhaus, Essen (Germany); Richardt, Gert [Herzzentrum, Segeberger Kliniken GmbH, Bad Segeberg (Germany); Mehilli, Julinda [Department of Cardiology, Klinikum Großhadern, Ludwig- Maximilian Universität, Munich (Germany); Wöhrle, Jochen [Department of Internal Medicine II, University of Ulm, Ulm (Germany); Neumann, Till; Biermann, Janine [University of Essen, Department of Cardiology, Essen (Germany); Zahn, Ralf [Abteilung für Kardiologie, Herzzentrum Ludwigshafen, Ludwigshafen (Germany); Kastner, Johannes [Department of Cardiology, University of Vienna Medical School, Vienna (Austria); Schmermund, Axel [CCB, Cardioangiologisches Centrum Bethanien, Frankfurt (Germany); Pfannebecker, Thomas [Abbott Vascular Deutschland GmbH, Wetzlar (Germany); Schneider, Steffen; Limbourg, Tobias [Institut für Herzinfarktforschung, Ludwigshafen (Germany); Hamm, Christian W. [University of Giessen, Medizinische Klinik I, Department of Cardiology, Giessen (Germany); Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim (Germany)

    2016-01-15

    Background: Third-generation drug-eluting metal stents are the gold standard for treatment of coronary artery disease. The permanent metallic caging of the vessel, however, can result in limited vasomotion, chronic inflammation, and late expansive remodeling, conditions that can lead to late and very late stent thrombosis. The development of bioresorbable scaffolds (BRSs) promises advantages over metal stents due to complete biodegradation within 2–4 years. Theoretically, since vessel scaffolding is temporary and no permanent implant remains in the vessel, BRSs, as opposed to metal stents, once degraded would no longer be potential triggers for stent-related adverse events or side effects. Methods/design: The short- and long-term outcome after implantation of an everolimus-eluting, poly-L-lactic acid-based bioresorbable scaffold system (ABSORB, Abbott Vascular, Santa Clara, CA, USA) in the world-wide greatest all-comers cohort will be evaluated in the prospective, non-interventional, multicenter German–Austrian ABSORB RegIstRy (GABI-R). GABI-R will include over 5000 patients from about 100 study sites in Austria and Germany. Safety endpoints such as cardiac death, myocardial infarction, and clinically driven percutaneous or surgical target lesion and vessel revascularization will be evaluated during hospitalization and in the follow-up period (minimum of 5 years). Conclusion: Although two randomized controlled trials and several registries have documented safety and efficacy as well as non-inferiority of this everolimus-eluting ABSORB device compared with drug-eluting metal stents, the current knowledge regarding clinical application, treatment success, and long-term safety of using this BRS in daily routine is limited. Thus, the goal of GABI-R is to address this lack of information. - Highlights: • The GABI-R addresses a lack of data about bioresorbable scaffolds in daily practice. • 5000 patients with minimal in- and exclusion criteria at 100 sites will

  7. Evaluation of the short- and long-term safety and therapy outcomes of the everolimus-eluting bioresorbable vascular scaffold system in patients with coronary artery stenosis: Rationale and design of the German–Austrian ABSORB RegIstRy (GABI-R)

    International Nuclear Information System (INIS)

    Nef, Holger; Wiebe, Jens; Achenbach, Stefan; Münzel, Thomas; Naber, Christoph; Richardt, Gert; Mehilli, Julinda; Wöhrle, Jochen; Neumann, Till; Biermann, Janine; Zahn, Ralf; Kastner, Johannes; Schmermund, Axel; Pfannebecker, Thomas; Schneider, Steffen; Limbourg, Tobias; Hamm, Christian W.

    2016-01-01

    Background: Third-generation drug-eluting metal stents are the gold standard for treatment of coronary artery disease. The permanent metallic caging of the vessel, however, can result in limited vasomotion, chronic inflammation, and late expansive remodeling, conditions that can lead to late and very late stent thrombosis. The development of bioresorbable scaffolds (BRSs) promises advantages over metal stents due to complete biodegradation within 2–4 years. Theoretically, since vessel scaffolding is temporary and no permanent implant remains in the vessel, BRSs, as opposed to metal stents, once degraded would no longer be potential triggers for stent-related adverse events or side effects. Methods/design: The short- and long-term outcome after implantation of an everolimus-eluting, poly-L-lactic acid-based bioresorbable scaffold system (ABSORB, Abbott Vascular, Santa Clara, CA, USA) in the world-wide greatest all-comers cohort will be evaluated in the prospective, non-interventional, multicenter German–Austrian ABSORB RegIstRy (GABI-R). GABI-R will include over 5000 patients from about 100 study sites in Austria and Germany. Safety endpoints such as cardiac death, myocardial infarction, and clinically driven percutaneous or surgical target lesion and vessel revascularization will be evaluated during hospitalization and in the follow-up period (minimum of 5 years). Conclusion: Although two randomized controlled trials and several registries have documented safety and efficacy as well as non-inferiority of this everolimus-eluting ABSORB device compared with drug-eluting metal stents, the current knowledge regarding clinical application, treatment success, and long-term safety of using this BRS in daily routine is limited. Thus, the goal of GABI-R is to address this lack of information. - Highlights: • The GABI-R addresses a lack of data about bioresorbable scaffolds in daily practice. • 5000 patients with minimal in- and exclusion criteria at 100 sites will

  8. SHORT COMMUNICATION: Time measurement device with four femtosecond stability

    Science.gov (United States)

    Panek, Petr; Prochazka, Ivan; Kodet, Jan

    2010-10-01

    We present the experimental results of extremely precise timing in the sense of time-of-arrival measurements in a local time scale. The timing device designed and constructed in our laboratory is based on a new concept using a surface acoustic wave filter as a time interpolator. Construction of the device is briefly described. The experiments described were focused on evaluating the timing precision and stability. Low-jitter test pulses with a repetition frequency of 763 Hz were generated synchronously to the local time base and their times of arrival were measured. The resulting precision of a single measurement was typically 900 fs RMS, and a timing stability TDEV of 4 fs was achieved for time intervals in the range from 300 s to 2 h. To our knowledge this is the best value reported to date for the stability of a timing device. The experimental results are discussed and possible improvements are proposed.

  9. Real-time energy resources scheduling considering short-term and very short-term wind forecast

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Marco; Sousa, Tiago; Morais, Hugo; Vale, Zita [Polytechnic of Porto (Portugal). GECAD - Knowledge Engineering and Decision Support Research Center

    2012-07-01

    This paper proposes an energy resources management methodology based on three distinct time horizons: day-ahead scheduling, hour-ahead scheduling, and real-time scheduling. In each scheduling process the update of generation and consumption operation and of the storage and electric vehicles storage status are used. Besides the new operation conditions, the most accurate forecast values of wind generation and of consumption using results of short-term and very short-term methods are used. A case study considering a distribution network with intensive use of distributed generation and electric vehicles is presented. (orig.)

  10. The history of time a very short introduction

    CERN Document Server

    Holford-Strevens, Leofranc

    2005-01-01

    Leofranc Holford-Strevens explores time measurement and the organisation of time into hours, days, months and years using a range of fascinating examples from Ancient Rome and Julius Caesar's Leap Year, to the 1920s' project for a fixed Easter. - ;Why do we measure time in the way that we do? Why is a week seven days long? At what point did minutes and seconds come into being? Why are some calendars lunar and some solar? The organisation of time into hours, days, months and years seems immutable and universal, but is actually far more artificial than most people realise. The French Revolution

  11. Short Vigilance Tasks are Hard Work Even If Time Flies

    Science.gov (United States)

    2016-10-21

    maintaining the data needed , and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other...actual time. Upon completion of the task, participants filled out questionnaires related to the hedonic and temporal evaluation of the task. Participants...time. Upon completion of the task, participants filled out questionnaires related to the hedonic and temporal evaluation of the task. Participants

  12. Perception of short time scale intervals in a hypnotic virtuoso

    NARCIS (Netherlands)

    Noreika, Valdas; Falter, Christine M.; Arstila, Valtteri; Wearden, John H.; Kallio, Sakari

    2012-01-01

    Previous studies showed that hypnotized individuals underestimate temporal intervals in the range of several seconds to tens of minutes. However, no previous work has investigated whether duration perception is equally disorderly when shorter time intervals are probed. In this study, duration

  13. Dollars and Deadlines: Rule Reforms in Short Time Frames

    Science.gov (United States)

    ABSTRACT: In "At Last! Aye, and there's the Rub" (i.e., the target article for this commentary), Capron describes challenges related to the timing for development, adoption, and revision of the Common Rule. Specifically, what the National Commission thought would be a...

  14. Tests for nonlinearity in short stationary time series

    International Nuclear Information System (INIS)

    Chang, T.; Sauer, T.; Schiff, S.J.

    1995-01-01

    To compare direct tests for detecting determinism in chaotic time series, data from Henon, Lorenz, and Mackey--Glass equations were contaminated with various levels of additive colored noise. These data were analyzed with a variety of recently developed tests for determinism, and the results compared

  15. PASTEURISASI HIGH TEMPERATURE SHORT TIME (HTST) SUSU TERHADAP Listeria monocytogenes PADA PENYIMPANAN REFRIGERATOR

    OpenAIRE

    SABIL, SYAHRIANA

    2015-01-01

    2015 SYAHRIANA SABIL (I 111 11 273). Pasteurisasi High Temperature Short Time (HTST) Susu terhadap Listeria monocytogenes pada Penyimpanan Refrigerator. Dibimbing oleh RATMAWATI MALAKA dan FARIDA NUR YULIATI. Pasteurisasi High Temperature Short Time (HTST) merupakan proses pemanasan susu di bawah titik didih yang diharapkan dapat membunuh Listeria monocytogenes (L. monocytogenes) karena bersifat patogen dan mengakibatkan listeriosis yang merupakan penyakit zoonosis. Tu...

  16. Elution behaviors of elements from the hair

    International Nuclear Information System (INIS)

    Akashi, Junko; Fukushima, Ichiro; Imahori, Akira

    1981-01-01

    The elution of the neutron activated elements out of hair soaked in some organic solvents and EDTA solution was studied. Soakage of the hair sample, which was washed with water and acetone in advance as IAEA's proposal, in ether and acetone for 30 minutes each resulted in no elution of Hg, Zn, Co and Se. Elution of Zn and Co from the powdered hair sample soaked in 0.1 M EDTA solution was rapid, while Zn did not elute out from the cut hair (2 -- 3 mm length) on the same condition. Hg, Se and Au were not eluted out by 0.1 M EDTA solution in the both case of cut hair and of powdered hair. Br was removed by 0.1 M EDTA solution from the cut hair and from the powdered hair with equal ease. (author)

  17. Time manages interference in visual short-term memory.

    Science.gov (United States)

    Smith, Amy V; McKeown, Denis; Bunce, David

    2017-09-01

    Emerging evidence suggests that age-related declines in memory may reflect a failure in pattern separation, a process that is believed to reduce the encoding overlap between similar stimulus representations during memory encoding. Indeed, behavioural pattern separation may be indexed by a visual continuous recognition task in which items are presented in sequence and observers report for each whether it is novel, previously viewed (old), or whether it shares features with a previously viewed item (similar). In comparison to young adults, older adults show a decreased pattern separation when the number of items between "old" and "similar" items is increased. Yet the mechanisms of forgetting underpinning this type of recognition task are yet to be explored in a cognitively homogenous group, with careful control over the parameters of the task, including elapsing time (a critical variable in models of forgetting). By extending the inter-item intervals, number of intervening items and overall decay interval, we observed in a young adult sample (N = 35, M age  = 19.56 years) that the critical factor governing performance was inter-item interval. We argue that tasks using behavioural continuous recognition to index pattern separation in immediate memory will benefit from generous inter-item spacing, offering protection from inter-item interference.

  18. Short-term adaptations as a response to travel time: results of a stated adaptation experimentincreases

    NARCIS (Netherlands)

    Psarra, I.; Arentze, T.A.; Timmermans, H.J.P.

    2016-01-01

    This study focused on short-term dynamics of activity-travel behavior as a response to travel time increases. It is assumed that short-term changes are triggered by stress, which is defined as the deviation between an individual’s aspirations and his or her daily experiences. When stress exceeds a

  19. Outcome of everolimus eluting bioabsorbable vascular scaffold (BVS) compared to non BVS drug eluting stent in the management of ST-segment elevation myocardial infarction (STEMI) — A comparative study

    Energy Technology Data Exchange (ETDEWEB)

    Chakraborty, Rabin; Patra, Soumya, E-mail: dr_soumyapatra@rediffmail.com; Banerjee, Suvro; Pande, Arindam; Khan, Aftab; Mandol, Prakash Chandra; Ghosh, Debashish; De, Swapan Kumar; Das, Sankha Subhro; Nag, Raja

    2016-04-15

    Background: The safety and efficacy of everolimus eluting bioabsorbable vascular scaffold (BVS) in the management of “ST” segment elevation myocardial infarction (STEMI) are yet to be established. Aims: To evaluate immediate and short term safety and efficacy of the everolimus-eluting ABSORB BVS compared with non BVS drug eluting stent (DES) in patients with STEMI. Methods: From December 2013 to December 2014, 220 patients with STEMI were included in this study. Among them, 35 patients treated with BVS were compared with a control group composed of 180 patients who underwent non BVS DES implantation in the same time period. The incidence of major adverse cardiac events (MACE: stent thrombosis: death, non-fatal myocardial infarction, or target vessel/lesion revascularization) before discharge and up to six months was evaluated. Results: 1 vessel disease was more frequent whereas, 2 and 3 vessel disease was less frequent in BVS group. Procedural characteristics were also similar between groups, except for the use of post dilation (p = 0.04). Procedural success, in-hospital, and up to six-month MACE rates were similar between both groups. Definite or probable stent thrombosis did not occur (according to the ARC criteria) in BVS patients, though two patients during the index admission and another two patients in the first month after DES implantation had stent thrombosis. Conclusion: The use of the ABSORB BVS for STEMI is feasible and associated with good procedural safety, and angiographic success rate.

  20. Outcome of everolimus eluting bioabsorbable vascular scaffold (BVS) compared to non BVS drug eluting stent in the management of ST-segment elevation myocardial infarction (STEMI) — A comparative study

    International Nuclear Information System (INIS)

    Chakraborty, Rabin; Patra, Soumya; Banerjee, Suvro; Pande, Arindam; Khan, Aftab; Mandol, Prakash Chandra; Ghosh, Debashish; De, Swapan Kumar; Das, Sankha Subhro; Nag, Raja

    2016-01-01

    Background: The safety and efficacy of everolimus eluting bioabsorbable vascular scaffold (BVS) in the management of “ST” segment elevation myocardial infarction (STEMI) are yet to be established. Aims: To evaluate immediate and short term safety and efficacy of the everolimus-eluting ABSORB BVS compared with non BVS drug eluting stent (DES) in patients with STEMI. Methods: From December 2013 to December 2014, 220 patients with STEMI were included in this study. Among them, 35 patients treated with BVS were compared with a control group composed of 180 patients who underwent non BVS DES implantation in the same time period. The incidence of major adverse cardiac events (MACE: stent thrombosis: death, non-fatal myocardial infarction, or target vessel/lesion revascularization) before discharge and up to six months was evaluated. Results: 1 vessel disease was more frequent whereas, 2 and 3 vessel disease was less frequent in BVS group. Procedural characteristics were also similar between groups, except for the use of post dilation (p = 0.04). Procedural success, in-hospital, and up to six-month MACE rates were similar between both groups. Definite or probable stent thrombosis did not occur (according to the ARC criteria) in BVS patients, though two patients during the index admission and another two patients in the first month after DES implantation had stent thrombosis. Conclusion: The use of the ABSORB BVS for STEMI is feasible and associated with good procedural safety, and angiographic success rate.

  1. Determination of rail wear and short-time wear measurements of rails applying radioisotopes

    International Nuclear Information System (INIS)

    Grohmann, H.D.

    1981-01-01

    An energetic model has been developed for calculating rail wear. Short-time wear tests on rails after surface activation and following activity measurements showed a good agreement with the calculated values

  2. Determination of Permissible Short-Time Emergency Overloading of Turbo-Generators and Synchronous Compensators

    Directory of Open Access Journals (Sweden)

    V. A. Anischenko

    2011-01-01

    Full Text Available The paper shows that failure to take into account variable ratio of short-time emergency overloading of turbo-generators (synchronous compensators that can lead to underestimation of overloading capacity or impermissible insulation over-heating.A method has been developed for determination of permissible duration of short-time emergency over-loading that takes into account changes of over-loading ratio in case of a failure.

  3. Time-dependent Bragg diffraction and short-pulse reflection by one-dimensional photonic crystals

    International Nuclear Information System (INIS)

    André, Jean-Michel; Jonnard, Philippe

    2015-01-01

    The time-dependence of the Bragg diffraction by one-dimensional photonic crystals and its influence on the short pulse reflection are studied in the framework of the coupled-wave theory. The indicial response of the photonic crystal is calculated and it appears that it presents a time-delay effect with a transient time conditioned by the extinction length. A numerical simulation is presented for a Bragg mirror in the x-ray domain and a pulse envelope modelled by a sine-squared shape. The potential consequences of the time-delay effect in time-dependent optics of short-pulses are emphasized. (paper)

  4. Temporal Prediction Errors Affect Short-Term Memory Scanning Response Time.

    Science.gov (United States)

    Limongi, Roberto; Silva, Angélica M

    2016-11-01

    The Sternberg short-term memory scanning task has been used to unveil cognitive operations involved in time perception. Participants produce time intervals during the task, and the researcher explores how task performance affects interval production - where time estimation error is the dependent variable of interest. The perspective of predictive behavior regards time estimation error as a temporal prediction error (PE), an independent variable that controls cognition, behavior, and learning. Based on this perspective, we investigated whether temporal PEs affect short-term memory scanning. Participants performed temporal predictions while they maintained information in memory. Model inference revealed that PEs affected memory scanning response time independently of the memory-set size effect. We discuss the results within the context of formal and mechanistic models of short-term memory scanning and predictive coding, a Bayes-based theory of brain function. We state the hypothesis that our finding could be associated with weak frontostriatal connections and weak striatal activity.

  5. Psychometric properties of the Hebrew short version of the Zimbardo Time Perspective Inventory.

    Science.gov (United States)

    Orkibi, Hod

    2015-06-01

    The purpose of this study was to develop a short Hebrew version of the Zimbardo Time Perspective Inventory that can be easily administered by health professionals in research, therapy, and counseling. First, the empirical links of time perspective (TP) to subjective well-being and health protective and health risk behaviors are reviewed. Then, a brief account of the instrument's previous modifications is provided. Results of confirmatory factor analysis (N = 572) verified the five-factor structure of the short version and yielded acceptable internal consistency reliability for each factor. The correlation coefficients between the five subscales of the short (20 items) and the original (56 items) instruments were all above .79, indicating the suitability of the short version for assessing the five TP factors. Support for the discriminant and concurrent validity was also achieved, largely in agreement with previous findings. Finally, limitations and future directions are addressed, and potential applications in therapy and counseling are offered. © The Author(s) 2014.

  6. Real-time mobile customer short message system design and implementation

    Science.gov (United States)

    Han, Qirui; Sun, Fang

    To expand the current mobile phone short message service, and to make the contact between schools, teachers, parents and feedback of the modern school office system more timely and conveniently, designed and developed the Short Message System based on the Linux platform. The state-of-the-art principles and designed proposals in the Short Message System based on the Linux platform are introduced. Finally we propose an optimized secure access authentication method. At present, many schools,vbusinesses and research institutions ratify the promotion and application the messaging system gradually, which has shown benign market prospects.

  7. Evaluation of electrochemical ion exchange for cesium elution

    International Nuclear Information System (INIS)

    Bontha, J.D.; Kurath, D.E.; Surma, J.E.; Buehler, M.F.

    1996-04-01

    Electrochemical elution was investigated as an alternative method to acid elution for the desorption of cesium from loaded ion exchange resins. The approach was found to have several potential advantages over existing technologies, in particular, electrochemical elution eliminates the need for addition of chemicals to elute cesium from the ion exchange resin. Also, since, in the electrochemical elution process the eluting solution is not in direct contact with the ion exchange material, very small volumes of the eluting solution can be used in a complete recycle mode in order to minimize the total volume of the cesium elute. In addition, the cesium is eluted as an alkaline solution that does not require neutralization with caustic to meet the tank farm specifications. Other advantages include easy incorporation of the electrochemical elution process into the present cesium recovery schemes

  8. Active mode-locking of mid-infrared quantum cascade lasers with short gain recovery time.

    Science.gov (United States)

    Wang, Yongrui; Belyanin, Alexey

    2015-02-23

    We investigate the dynamics of actively modulated mid-infrared quantum cascade lasers (QCLs) using space- and time-domain simulations of coupled density matrix and Maxwell equations with resonant tunneling current taken into account. We show that it is possible to achieve active mode locking and stable generation of picosecond pulses in high performance QCLs with a vertical laser transition and a short gain recovery time by bias modulation of a short section of a monolithic Fabry-Perot cavity. In fact, active mode locking in QCLs with a short gain recovery time turns out to be more robust to the variation of parameters as compared to previously studied lasers with a long gain recovery time. We investigate the effects of spatial hole burning and phase locking on the laser output.

  9. Towards enhanced automated elution systems for waterborne protozoa using megasonic energy.

    Science.gov (United States)

    Horton, B; Katzer, F; Desmulliez, M P Y; Bridle, H L

    2018-02-01

    Continuous and reliable monitoring of water sources for human consumption is imperative for public health. For protozoa, which cannot be multiplied efficiently in laboratory settings, concentration and recovery steps are key to a successful detection procedure. Recently, the use of megasonic energy was demonstrated to recover Cryptosporidium from commonly used water industry filtration procedures, forming thereby a basis for a simplified and cost effective method of elution of pathogens. In this article, we report the benefits of incorporating megasonic sonication into the current methodologies of Giardia duodenalis elution from an internationally approved filtration and elution system used within the water industry, the Filta-Max®. Megasonic energy assisted elution has many benefits over current methods since a smaller final volume of eluent allows removal of time-consuming centrifugation steps and reduces manual involvement resulting in a potentially more consistent and more cost-effective method. We also show that megasonic sonication of G. duodenalis cysts provides the option of a less damaging elution method compared to the standard Filta-Max® operation, although the elution from filter matrices is not currently fully optimised. A notable decrease in recovery of damaged cysts was observed in megasonic processed samples, potentially increasing the abilities of further genetic identification options upon isolation of the parasite from a filter sample. This work paves the way for the development of a fully automated and more cost-effective elution method of Giardia from water samples. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. An optimized method for elution of enteroviral RNA from a cellulose-based substrate.

    Science.gov (United States)

    Li, Yan; Yoshida, Hiromu; Wang, Lu; Tao, Zexin; Wang, Haiyan; Lin, Xiaojuan; Xu, Aiqiang

    2012-12-01

    The Flinders Technology Australia (FTA) Elute Card is a commercial product that facilitates the collection, transport, archiving and processing of nucleic acids from a wide variety of biological samples at room temperature. While the cards have been designed so that sterile/deionized water can elute DNA easily, they are not suitable for some less stable RNAs. This study was undertaken to determine the optimal conditions such as the buffer type, buffer pH and incubation temperature for the elution of enteroviral RNA from FTA Elute Cards prior to quantitative analysis using real-time PCR (qPCR) or consensus degenerate hybrid oligonucleotide primer VP1 RT-semi nested PCR (CODEHOP VP1 RT-snPCR). TE-1 (pH 8.0), rather than sterile water, was the best buffer for high efficiency elution of enteroviral RNA at 95°C. However, as the estimated recovery rate of viral RNA eluted from the cards averaged to be only 6.1%, enterovirus assays using FTA elution should be considered qualitative, especially at low virus titers, and therefore the results of the assay should be interpreted carefully. Copyright © 2012 Elsevier B.V. All rights reserved.

  11. Zotarolimus-eluting vs. sirolimus-eluting coronary stents in patients with and without acute coronary syndromes

    DEFF Research Database (Denmark)

    Thim, Troels; Maeng, Michael; Kaltoft, Anne Kjer

    2012-01-01

    To compare clinical outcomes among patients with acute coronary syndrome treated with zotarolimus-eluting and sirolimus-eluting stents in the SORT OUT III trial.......To compare clinical outcomes among patients with acute coronary syndrome treated with zotarolimus-eluting and sirolimus-eluting stents in the SORT OUT III trial....

  12. XIENCE V everolimus-eluting coronary stent system: a novel second generation drug-eluting stent

    NARCIS (Netherlands)

    Beijk, Marcel A. M.; Piek, Jon J.

    2007-01-01

    Drug-eluting stents (DES) have been shown to be safe and significantly reduce clinical events and angiographic restenosis in the percutaneous treatment of coronary artery disease. Currently, three DES have been approved in Europe and Northern America: the sirolimus-eluting stent (SES), the

  13. A short-time fading study of Al2O3:C

    International Nuclear Information System (INIS)

    Nascimento, L.F.; Vanhavere, F.; Silva, E.H.; Deene, Y. De

    2015-01-01

    This paper studies the short-time fading from Al 2 O 3 :C by measuring optically stimulated luminescence (OSL) signals (Total OSL: T OSL , and Peak OSL: P OSL ) from droplets and Luxel™ pellets. The influence of various bleaching regimes (blue, green and white) and light power is compared. The fading effect is the decay of the OSL signal in the dark at room temperature. Al 2 O 3 :C detectors were submitted to various bleaching regimes, irradiated with a reference dose and read out after different time spans. Investigations were carried out using 2 mm size droplet detectors, made of thin Al 2 O 3 :C powder mixed with a photocured polymer. Tests were compared to Luxel™-type detectors (Landauer Inc.). Short-time post-irradiation fading is present in OSL results (T OSL and P OSL ) droplets for time spans up to 200 s. The effect of short-time fading can be lowered/removed when treating the detectors with high-power and/or long time bleaching regimes; this result was observed in both T OSL and P OSL from droplets and Luxel™. - Highlights: • Droplet composed of thin powder of Al 2 O 3 :C was prepared using a photo-curable polymer. • Powder grain sizes ranged from 5 μm to 35 μm. • Short-time fading was measured for irradiated samples. • Various bleaching regimes and light power was tested. • Droplets were compared to a commercially dosimeter, Luxel™

  14. Ultra-short time sciences. From the atto-second to the peta-watts

    International Nuclear Information System (INIS)

    2000-01-01

    This book presents the recent advances in the scientific and technical domains linked with ultra-short time physics. It deals first with the conceptual and technological aspects of ultra-intense and ultra-brief lasers. Then, it describes the different domains of research (atoms, molecules and aggregates; gaseous phase dynamics using the pump-probe technique; femto-chemistry in dense phase; condensed matter; plasma physics; consistent control; aerosols; functional femto-biology) and the different domains of application (medical diagnosis; ophthalmology; telecommunications; technological and industrial developments). A last part is devoted to the teaching of ultra-short time sciences. (J.S.)

  15. Short-time, high-dosage penicillin infusion therapy of syphilis

    DEFF Research Database (Denmark)

    Lomholt, Hans; Poulsen, Asmus; Brandrup, Flemming

    2003-01-01

    The optimal dosage and duration of penicillin treatment for the various stages of syphilis are not known. We present data on 20 patients with syphilis (primary, secondary or latent) treated with high-dose, short-time penicillin infusion therapy. Patients were given 10 MIU of penicillin G intraven......The optimal dosage and duration of penicillin treatment for the various stages of syphilis are not known. We present data on 20 patients with syphilis (primary, secondary or latent) treated with high-dose, short-time penicillin infusion therapy. Patients were given 10 MIU of penicillin G...

  16. The role of short-time intensity and envelope power for speech intelligibility and psychoacoustic masking.

    Science.gov (United States)

    Biberger, Thomas; Ewert, Stephan D

    2017-08-01

    The generalized power spectrum model [GPSM; Biberger and Ewert (2016). J. Acoust. Soc. Am. 140, 1023-1038], combining the "classical" concept of the power-spectrum model (PSM) and the envelope power spectrum-model (EPSM), was demonstrated to account for several psychoacoustic and speech intelligibility (SI) experiments. The PSM path of the model uses long-time power signal-to-noise ratios (SNRs), while the EPSM path uses short-time envelope power SNRs. A systematic comparison of existing SI models for several spectro-temporal manipulations of speech maskers and gender combinations of target and masker speakers [Schubotz et al. (2016). J. Acoust. Soc. Am. 140, 524-540] showed the importance of short-time power features. Conversely, Jørgensen et al. [(2013). J. Acoust. Soc. Am. 134, 436-446] demonstrated a higher predictive power of short-time envelope power SNRs than power SNRs using reverberation and spectral subtraction. Here the GPSM was extended to utilize short-time power SNRs and was shown to account for all psychoacoustic and SI data of the three mentioned studies. The best processing strategy was to exclusively use either power or envelope-power SNRs, depending on the experimental task. By analyzing both domains, the suggested model might provide a useful tool for clarifying the contribution of amplitude modulation masking and energetic masking.

  17. Computation of the Short-Time Linear Canonical Transform with Dual Window

    Directory of Open Access Journals (Sweden)

    Lei Huang

    2017-01-01

    Full Text Available The short-time linear canonical transform (STLCT, which maps the time domain signal into the joint time and frequency domain, has recently attracted some attention in the area of signal processing. However, its applications are still limited due to the fact that selection of coefficients of the short-time linear canonical series (STLCS is not unique, because time and frequency elementary functions (together known as basis function of STLCS do not constitute an orthogonal basis. To solve this problem, this paper investigates a dual window solution. First, the nonorthogonal problem that suffered from original window is fulfilled by orthogonal condition with dual window. Then based on the obtained condition, a dual window computation approach of the GT is extended to the STLCS. In addition, simulations verify the validity of the proposed condition and solutions. Furthermore, some possible applied directions are discussed.

  18. Viruses as groundwater tracers: using ecohydrology to characterize short travel times in aquifers

    Science.gov (United States)

    Hunt, Randall J.; Borchardt, Mark A.; Bradbury, Kenneth R.

    2014-01-01

    Viruses are attractive tracers of short (population over time; therefore, the virus snapshot shed in the fecal wastes of an infected population at a specific point in time can serve as a marker for tracking virus and groundwater movement. The virus tracing approach and an example application are described to illustrate their ability to characterize travel times in high-groundwater velocity settings, and provide insight unavailable from standard hydrogeologic approaches. Although characterization of preferential flowpaths does not usually characterize the majority of other travel times occurring in the groundwater system (e.g., center of plume mass; tail of the breakthrough curve), virus approaches can trace very short times of transport, and thus can fill an important gap in our current hydrogeology toolbox.

  19. [Drug-eluting stent thrombosis and its pharmacological prevention].

    Science.gov (United States)

    Pershukov, I V; Batyraliev, T A

    2007-01-01

    The problem of drug eluting stents (DES) safety has been actively discussed throughout 2006 because of increase of frequency of development of late stent thromboses which were noted during almost 2 years after stenting. In December 2006 US Food and Drug Administration (FDA) advisory panel acknowledged increase of development of late stent thrombosis. At the same time FDA accepted new definition of stent-thrombosis suggested by the Academic Research Consortium. According to this definition thrombosis can be definite, probable and possible. Any unexplained death before end of follow-up in a trial should be considered thrombosis related. Recalculation of thrombosis rate using this definition caused pronounced increase of this parameter in previously conducted trials. Thrombosis rate rose from 0,6 to 3,3% for bare metal stents, from 0,8 to 3,6% for sirolimus eluting stents and from 1,3 to 3,5% for paclitaxel eluting stents. Professional cardiological and angiographical societies (ACC, AHA, SCAI) responding to FDA advisory panel published their proofs and vision of the problem of stent thrombosis. In February 2007 ACC, AHA, SCAI, American College of Surgeons and Association of Dentists published scientific bulletin in which described preventive measures aimed at lowering of risk of thrombosis development. This document contains strict recommendation to continue double antithrombotic therapy with aspirin and clopidogrel for 12 months after implantation of DES or abandonment of the use of this type of stents when long term double antithrombotic therapy is not possible.

  20. Corrections for the combined effects of decay and dead time in live-timed counting of short-lived radionuclides

    International Nuclear Information System (INIS)

    Fitzgerald, R.

    2016-01-01

    Studies and calibrations of short-lived radionuclides, for example "1"5O, are of particular interest in nuclear medicine. Yet counting experiments on such species are vulnerable to an error due to the combined effect of decay and dead time. Separate decay corrections and dead-time corrections do not account for this issue. Usually counting data are decay-corrected to the start time of the count period, or else instead of correcting the count rate, the mid-time of the measurement is used as the reference time. Correction factors are derived for both those methods, considering both extending and non-extending dead time. Series approximations are derived here and the accuracy of those approximations are discussed. - Highlights: • Derived combined effects of decay and dead time. • Derived for counting systems with extending or non-extending dead times. • Derived series expansions for both midpoint and decay-to-start-time methods. • Useful for counting experiments with short-lived radionuclides. • Examples given for "1"5O, used in PET scanning.

  1. NMR transmit-receive system with short recovery time and effective isolation

    Science.gov (United States)

    Jurga, K.; Reynhardt, E. C.; Jurga, S.

    A transmit-receive system with a short recovery time and excellent isolation has been developed. The system operates in conjunction with an ENI Model 3200L broadband amplifier and a spin-lock NMR pulse spectrometer. The system has been tested in the frequency range 5.5 to 52 MHz and seems not to generate any background noise.

  2. A Unified Framework for Estimating Minimum Detectable Effects for Comparative Short Interrupted Time Series Designs

    Science.gov (United States)

    Price, Cristofer; Unlu, Fatih

    2014-01-01

    The Comparative Short Interrupted Time Series (C-SITS) design is a frequently employed quasi-experimental method, in which the pre- and post-intervention changes observed in the outcome levels of a treatment group is compared with those of a comparison group where the difference between the former and the latter is attributed to the treatment. The…

  3. Eulerian short-time statistics of turbulent flow at large Reynolds number

    NARCIS (Netherlands)

    Brouwers, J.J.H.

    2004-01-01

    An asymptotic analysis is presented of the short-time behavior of second-order temporal velocity structure functions and Eulerian acceleration correlations in a frame that moves with the local mean velocity of the turbulent flow field. Expressions in closed-form are derived which cover the viscous

  4. Modular High Voltage Pulse Converter for Short Rise and Decay Times

    NARCIS (Netherlands)

    Mao, S.

    2018-01-01

    This thesis explores a modular HV pulse converter technology with short rise and decay times. A systematic methodology to derive and classify HV architectures based on a modularization level of power building blocks of the HV pulse converter is developed to summarize existing architectures and

  5. Extracting biologically significant patterns from short time series gene expression data

    Directory of Open Access Journals (Sweden)

    McGinnis Thomas

    2009-08-01

    Full Text Available Abstract Background Time series gene expression data analysis is used widely to study the dynamics of various cell processes. Most of the time series data available today consist of few time points only, thus making the application of standard clustering techniques difficult. Results We developed two new algorithms that are capable of extracting biological patterns from short time point series gene expression data. The two algorithms, ASTRO and MiMeSR, are inspired by the rank order preserving framework and the minimum mean squared residue approach, respectively. However, ASTRO and MiMeSR differ from previous approaches in that they take advantage of the relatively few number of time points in order to reduce the problem from NP-hard to linear. Tested on well-defined short time expression data, we found that our approaches are robust to noise, as well as to random patterns, and that they can correctly detect the temporal expression profile of relevant functional categories. Evaluation of our methods was performed using Gene Ontology (GO annotations and chromatin immunoprecipitation (ChIP-chip data. Conclusion Our approaches generally outperform both standard clustering algorithms and algorithms designed specifically for clustering of short time series gene expression data. Both algorithms are available at http://www.benoslab.pitt.edu/astro/.

  6. X-ray testing for short-time dynamic applications; Roentgenuntersuchungen fuer kurzzeitdynamische Anwendungen

    Energy Technology Data Exchange (ETDEWEB)

    Kurfiss, Malte; Moser, Stefan; Popko, Gregor; Nau, Siegfried [Fraunhofer-Institut fuer Kurzzeitdynamik, Efringen-Kirchen (Germany). Ernst-Mach-Inst. (EMI)

    2017-08-01

    For nondestructive testing purposes new challenges are short-time dynamic processes. The application of x-ray flash tubes and modern high-speed cameras allows the observation of the opening of air-bags or the energy absorption of compressed tubes as occurring during a vehicle crash. Special algorithms designed for computerized tomography analyses allow the 3D reconstruction at individual time points of the dynamic process. Possibilities and limitations of the actual techniques are discussed.

  7. Rotor-System Log-Decrement Identification Using Short-Time Fourier-Transform Filter

    OpenAIRE

    Li, Qihang; Wang, Weimin; Chen, Lifang; Sun, Dan

    2015-01-01

    With the increase of the centrifugal compressor capability, such as large scale LNG and CO2 reinjection, the stability margin evaluation is crucial to assure the compressor work in the designed operating conditions in field. Improving the precision of parameter identification of stability is essential and necessary as well. Based on the time-varying characteristics of response vibration during the sine-swept process, a short-time Fourier transform (STFT) filter was introduced to increase the ...

  8. Spectrogram analysis of selected tremor signals using short-time Fourier transform and continuous wavelet transform

    Energy Technology Data Exchange (ETDEWEB)

    Bartosch, T. [Erlanger-Nuernberg Univ., Erlanger (Germany). Lehrstul fuer Nachrichtentechnik I; Seidl, D. [Seismologisches Zentralobservatorium Graefenberg, Erlanegen (Greece). Bundesanstalt fuer Geiwissenschaften und Rohstoffe

    1999-06-01

    Among a variety of spectrogram methods short-time Fourier transform (STFT) and continuous wavelet transform (CWT) were selected to analyse transients in non-stationary signals. Depending on the properties of the tremor signals from the volcanos Mt. Stromboli, Mt. Semeru and Mt. Pinatubo were analyzed using both methods. The CWT can also be used to extend the definition of coherency into a time-varying coherency spectrogram. An example is given using array data from the volcano Mt. Stromboli (Italy).

  9. Radioactive cesium elution speed in dried wild Mushrooms collected in 2015

    International Nuclear Information System (INIS)

    Yamaguchi, Toshiro; Arai, Hirotsugu; Ohnuma, Tohru; Arai, Hiromu; Takyu, Sodai; Matsuyama, Tetsuo; Ishii, Keizo

    2016-01-01

    Dried wild mushrooms (12 species, 13 samples) collected in Nagano, Fukushima, and Miyagi Prefectures, Japan, in 2015 were immersed in water for 1,440 min. The elution rate of radioactive cesium (Cs) was calculated based on its radioactivity, which was measured with a high-purity germanium semiconductor detector (GX2018; CANBERRA Industries, Meriden, CT, USA) before and after immersion for each mushroom. Immersion fluid was sampled after 10, 30, 60, 180, 360, and 1,440 min of immersion and dried on aluminum foil. Then, imaging plates (BAS-III, Fujifilm, Tokyo, Japan) exposed to the dried immersion fluid were measured with a Bio-imaging Analyzer System-1800 II (Fujifilm). The 50% elution time of each wild mushroom was calculated based on the photo stimulated luminescence density of the autoradiographs. The radioactive Cs elution rate was > 80% for 11 samples (84% of total) comprising 11 mushroom species. Moreover, the 50% elution time was < 30 min for 9 samples (69% of total) comprising 9 species. This shows that the radioactive Cs elution rate and elution speed were not constant among mushroom species. Based on these results, immersing the mushrooms, which were dried, in water for at least 120 min is an effective method for removing radioactive Cs from wild mushrooms. (author)

  10. Softening and elution of monomers in ethanol

    DEFF Research Database (Denmark)

    Benetti, Ana Raquel; Asmussen, Erik; Munksgaard, E Christian

    2009-01-01

    The purpose of this study was to investigate the effect of light-curing protocol on softening and elution of monomers in ethanol as measured on a model polymer. It was a further aim to correlate the measured values with previously reported data on degree of conversion and glass transition...

  11. The effect of long and short time oil shocks on economic growth in Iran

    OpenAIRE

    Sayyed Abdolmajid Jalae; Sanaz Mohammadi

    2012-01-01

    Oil is one of the strategic good so that price fluctuations and shocks of it have major effects on economic growth and recession in depended countries to revenues of it. In this study, it is tried that the effect of oil price shocks investigated in two types (short and long time) on Economic growth in Iran. Its Period is from 1974 to 2006. According it, oil price uncertainty is quantized by GARCH model and is determined the effects of oil price shocks on economic growth in Iran during a short...

  12. The time of onset of abnormal calcification in spondylometaepiphyseal dysplasia, short limb-abnormal calcification type

    Energy Technology Data Exchange (ETDEWEB)

    Tueysuez, Beyhan [Istanbul University, Department of Pediatric Genetics, Cerrahpasa Medical School, Istanbul (Turkey); Gazioglu, Nurperi [Istanbul University, Department of Neurosurgery, Cerrahpasa Medical School, Istanbul (Turkey); Uenguer, Savas [Istanbul University, Department of Pediatric Radiology, Cerrahpasa Medical School, Istanbul (Turkey); Aji, Dolly Yafet [Istanbul University, Department of Pediatrics, Cerrahpasa Medical School, Istanbul (Turkey); Tuerkmen, Seval [Istanbul University, Department of Pediatric Genetics, Cerrahpasa Medical School, Istanbul (Turkey); Universitatsklinikum Berlin, Charite Virchow-Klinik, Berlin (Germany)

    2009-01-15

    A 1-month-old boy with shortness of extremities on prenatal US was referred to our department with a provisional diagnosis of achondroplasia. His height was normal but he had short extremities and platyspondyly, premature carpal epiphyses on both hands, and short tubular bones with irregular metaphyses on radiographs. Re-evaluation of the patient at the age of 1 year revealed very short height and premature calcification of the costal cartilages and epiphyses. Spondylometaepiphyseal dysplasia (SMED), short limb-abnormal calcification type was diagnosed. This condition is a very rare autosomal recessively inherited disorder, and most of the patients die in early childhood due to neurological involvement. At the age of 2 years and 5 months, a CT scan showed narrowing of the cervical spinal canal. One month later he died suddenly because of spinal cord injury. In conclusion early diagnosis is very important because the recurrence risk is high and patients may die due to early neurological complications. The time of onset of abnormal calcifications, a diagnostic finding of the disease, is at the age of around 1 year in most patients. When abnormal calcifications are not yet present, but radiological changes associated with SMED are present, this rare disease must be considered. (orig.)

  13. The time of onset of abnormal calcification in spondylometaepiphyseal dysplasia, short limb-abnormal calcification type

    International Nuclear Information System (INIS)

    Tueysuez, Beyhan; Gazioglu, Nurperi; Uenguer, Savas; Aji, Dolly Yafet; Tuerkmen, Seval

    2009-01-01

    A 1-month-old boy with shortness of extremities on prenatal US was referred to our department with a provisional diagnosis of achondroplasia. His height was normal but he had short extremities and platyspondyly, premature carpal epiphyses on both hands, and short tubular bones with irregular metaphyses on radiographs. Re-evaluation of the patient at the age of 1 year revealed very short height and premature calcification of the costal cartilages and epiphyses. Spondylometaepiphyseal dysplasia (SMED), short limb-abnormal calcification type was diagnosed. This condition is a very rare autosomal recessively inherited disorder, and most of the patients die in early childhood due to neurological involvement. At the age of 2 years and 5 months, a CT scan showed narrowing of the cervical spinal canal. One month later he died suddenly because of spinal cord injury. In conclusion early diagnosis is very important because the recurrence risk is high and patients may die due to early neurological complications. The time of onset of abnormal calcifications, a diagnostic finding of the disease, is at the age of around 1 year in most patients. When abnormal calcifications are not yet present, but radiological changes associated with SMED are present, this rare disease must be considered. (orig.)

  14. Short time propagation of a singular wave function: Some surprising results

    Science.gov (United States)

    Marchewka, A.; Granot, E.; Schuss, Z.

    2007-08-01

    The Schrödinger evolution of an initially singular wave function was investigated. First it was shown that a wide range of physical problems can be described by initially singular wave function. Then it was demonstrated that outside the support of the initial wave function the time evolution is governed to leading order by the values of the wave function and its derivatives at the singular points. Short-time universality appears where it depends only on a single parameter—the value at the singular point (not even on its derivatives). It was also demonstrated that the short-time evolution in the presence of an absorptive potential is different than in the presence of a nonabsorptive one. Therefore, this dynamics can be harnessed to the determination whether a potential is absorptive or not simply by measuring only the transmitted particles density.

  15. Flow characteristics of a pilot-scale high temperature, short time pasteurizer.

    Science.gov (United States)

    Tomasula, P M; Kozempel, M F

    2004-09-01

    In this study, we present a method for determining the fastest moving particle (FMP) and residence time distribution (RTD) in a pilot-scale high temperature, short time (HTST) pasteurizer to ensure that laboratory or pilot-scale HTST apparatus meets the Pasteurized Milk Ordinance standards for pasteurization of milk and can be used for obtaining thermal inactivation data. The overall dimensions of the plate in the pasteurizer were 75 x 115 mm, with a thickness of 0.5 mm and effective diameter of 3.0 mm. The pasteurizer was equipped with nominal 21.5- and 52.2-s hold tubes, and flow capacity was variable from 0 to 20 L/h. Tracer studies were used to determine FMP times and RTD data to establish flow characteristics. Using brine milk as tracer, the FMP time for the short holding section was 18.6 s and for the long holding section was 36 s at 72 degrees C, compared with the nominal times of 21.5 and 52.2 s, respectively. The RTD study indicates that the short hold section was 45% back mixed and 55% plug flow for whole milk at 72 degrees C. The long hold section was 91% plug and 9% back mixed for whole milk at 72 degrees C. This study demonstrates that continuous laboratory and pilot-scale pasteurizers may be used to study inactivation of microorganisms only if the flow conditions in the holding tube are established for comparison with commercial HTST systems.

  16. Difference-based clustering of short time-course microarray data with replicates

    Directory of Open Access Journals (Sweden)

    Kim Jihoon

    2007-07-01

    Full Text Available Abstract Background There are some limitations associated with conventional clustering methods for short time-course gene expression data. The current algorithms require prior domain knowledge and do not incorporate information from replicates. Moreover, the results are not always easy to interpret biologically. Results We propose a novel algorithm for identifying a subset of genes sharing a significant temporal expression pattern when replicates are used. Our algorithm requires no prior knowledge, instead relying on an observed statistic which is based on the first and second order differences between adjacent time-points. Here, a pattern is predefined as the sequence of symbols indicating direction and the rate of change between time-points, and each gene is assigned to a cluster whose members share a similar pattern. We evaluated the performance of our algorithm to those of K-means, Self-Organizing Map and the Short Time-series Expression Miner methods. Conclusions Assessments using simulated and real data show that our method outperformed aforementioned algorithms. Our approach is an appropriate solution for clustering short time-course microarray data with replicates.

  17. Dimension reduction of frequency-based direct Granger causality measures on short time series.

    Science.gov (United States)

    Siggiridou, Elsa; Kimiskidis, Vasilios K; Kugiumtzis, Dimitris

    2017-09-01

    The mainstream in the estimation of effective brain connectivity relies on Granger causality measures in the frequency domain. If the measure is meant to capture direct causal effects accounting for the presence of other observed variables, as in multi-channel electroencephalograms (EEG), typically the fit of a vector autoregressive (VAR) model on the multivariate time series is required. For short time series of many variables, the estimation of VAR may not be stable requiring dimension reduction resulting in restricted or sparse VAR models. The restricted VAR obtained by the modified backward-in-time selection method (mBTS) is adapted to the generalized partial directed coherence (GPDC), termed restricted GPDC (RGPDC). Dimension reduction on other frequency based measures, such the direct directed transfer function (dDTF), is straightforward. First, a simulation study using linear stochastic multivariate systems is conducted and RGPDC is favorably compared to GPDC on short time series in terms of sensitivity and specificity. Then the two measures are tested for their ability to detect changes in brain connectivity during an epileptiform discharge (ED) from multi-channel scalp EEG. It is shown that RGPDC identifies better than GPDC the connectivity structure of the simulated systems, as well as changes in the brain connectivity, and is less dependent on the free parameter of VAR order. The proposed dimension reduction in frequency measures based on VAR constitutes an appropriate strategy to estimate reliably brain networks within short-time windows. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Development of an elution device for ViroCap virus filters.

    Science.gov (United States)

    Fagnant, Christine Susan; Toles, Matthew; Zhou, Nicolette Angela; Powell, Jacob; Adolphsen, John; Guan, Yifei; Ockerman, Byron; Shirai, Jeffry Hiroshi; Boyle, David S; Novosselov, Igor; Meschke, John Scott

    2017-10-19

    Environmental surveillance of waterborne pathogens is vital for monitoring the spread of diseases, and electropositive filters are frequently used for sampling wastewater and wastewater-impacted surface water. Viruses adsorbed to electropositive filters require elution prior to detection or quantification. Elution is typically facilitated by a peristaltic pump, although this requires a significant startup cost and does not include biosafety or cross-contamination considerations. These factors may pose a barrier for low-resource laboratories that aim to conduct environmental surveillance of viruses. The objective of this study was to develop a biologically enclosed, manually powered, low-cost device for effectively eluting from electropositive ViroCap™ virus filters. The elution device described here utilizes a non-electric bilge pump, instead of an electric peristaltic pump or a positive pressure vessel. The elution device also fully encloses liquids and aerosols that could contain biological organisms, thereby increasing biosafety. Moreover, all elution device components that are used in the biosafety cabinet are autoclavable, reducing cross-contamination potential. This device reduces costs of materials while maintaining convenience in terms of size and weight. With this new device, there is little sample volume loss due to device inefficiency, similar virus yields were demonstrated during seeded studies with poliovirus type 1, and the time to elute filters is similar to that required with the peristaltic pump. The efforts described here resulted in a novel, low-cost, manually powered elution device that can facilitate environmental surveillance of pathogens through effective virus recovery from ViroCap filters while maintaining the potential for adaptability to other cartridge filters.

  19. Recent developments in drug eluting devices with tailored interfacial properties.

    Science.gov (United States)

    Sanchez-Rexach, Eva; Meaurio, Emilio; Sarasua, Jose-Ramon

    2017-11-01

    Drug eluting devices have greatly evolved during past years to become fundamental products of great marketing importance in the biomedical field. There is currently a large diversity of highly specialized devices for specific applications, making the development of these devices an exciting field of research. The replacement of the former bare metal devices by devices loaded with drugs allowed the sustained and controlled release of drugs, to achieve the desired local therapeutic concentration of drug. The newer devices have been "engineered" with surfaces containing micro- and nanoscale features in a well-controlled manner, that have shown to significantly affect cellular and subcellular function of various biological systems. For example, the topography can be structured to form an antifouling surface mimicking the defense mechanisms found in nature, like the skin of the shark. In the case of bone implants, well-controlled nanostructured interfaces can promote osteoblast differentiation and matrix production, and enhance short-term and long-term osteointegration. In any case, the goal of current research is to design implants that induce controlled, guided, and rapid healing. This article reviews recent trends in the development of drug eluting devices, as well as recent developments on the micro/nanotechnology scales, and their future challenges. For this purpose medical devices have been divided according to the different systems of the body they are focused to: orthopedic devices, breathing stents, gastrointestinal and urinary systems, devices for cardiovascular diseases, neuronal implants, and wound dressings. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Short irradiation time characteristics of the inverter type X-ray generator

    International Nuclear Information System (INIS)

    Miyazaki, Shigeru; Hara, Takamitu; Matutani, Kazuo; Saito, Kazuhiko.

    1994-01-01

    The linearity of the X-ray output is an important factor in radiography. It is a composite of the linearities of the X-ray tube voltage, the X-ray tube current, and the exposure time. This paper focuses on the linearity of exposure time. Non-linearity of the X-ray output for short-time exposure became a problem when the three-phase X-ray generator was introduced. This paper describes the inverter-type X-ray generator, which is expected to become predominant in the future. Previously, we investigated X-ray output linearity during short-time exposure using the technique of dynamic study. In this paper, we describe the application of a digital memory and a personal computer to further investigation. The non-linearity of the X-ray output was caused by irregular waveforms of the X-ray tube voltage found at the rise time and the fall time. When the rise time was about 0.6 ms, the non-linearity was about 2%, which is negligibly small. The non-linearity due to the fall time of the X-ray tube varied greatly according to the X-ray tube current. For the minimum irradiation time of 1 ms, 4% to 27% of the non-linearity was attributable to the fall time. The main cause was the stray capacitance of the X-ray high-voltage cables. When the X-ray tube current exceeded 400 mA, the rise time was almost equal to the fall time, and the problem did not occur. Consequently, the ideal generator should have a fall time which is equal to the rise time of the X-ray tube voltage. Strictly speaking, such a generator should have rectangular waveforms. (author)

  1. Short-time existence of solutions for mean-field games with congestion

    KAUST Repository

    Gomes, Diogo A.

    2015-11-20

    We consider time-dependent mean-field games with congestion that are given by a Hamilton–Jacobi equation coupled with a Fokker–Planck equation. These models are motivated by crowd dynamics in which agents have difficulty moving in high-density areas. The congestion effects make the Hamilton–Jacobi equation singular. The uniqueness of solutions for this problem is well understood; however, the existence of classical solutions was only known in very special cases, stationary problems with quadratic Hamiltonians and some time-dependent explicit examples. Here, we demonstrate the short-time existence of C∞ solutions for sub-quadratic Hamiltonians.

  2. Spectral phase encoding of ultra-short optical pulse in time domain for OCDMA application.

    Science.gov (United States)

    Wang, Xu; Wada, Naoya

    2007-06-11

    We propose a novel reconfigurable time domain spectral phase encoding (SPE) scheme for coherent optical code-division-multiple-access application. In the proposed scheme, the ultra-short optical pulse is stretched by dispersive device and the SPE is done in time domain using high speed phase modulator. The time domain SPE scheme is robust to wavelength drift of the light source and is very flexible and compatible with the fiber optical system. Proof-of-principle experiments of encoding with 16-chip, 20 GHz/chip binary-phase-shift-keying codes and 1.25 Gbps data transmission have been successfully demonstrated together with an arrayed-wave-guide decoder.

  3. Short-time maximum entropy method analysis of molecular dynamics simulation: Unimolecular decomposition of formic acid

    Science.gov (United States)

    Takahashi, Osamu; Nomura, Tetsuo; Tabayashi, Kiyohiko; Yamasaki, Katsuyoshi

    2008-07-01

    We performed spectral analysis by using the maximum entropy method instead of the traditional Fourier transform technique to investigate the short-time behavior in molecular systems, such as the energy transfer between vibrational modes and chemical reactions. This procedure was applied to direct ab initio molecular dynamics calculations for the decomposition of formic acid. More reactive trajectories of dehydrolation than those of decarboxylation were obtained for Z-formic acid, which was consistent with the prediction of previous theoretical and experimental studies. Short-time maximum entropy method analyses were performed for typical reactive and non-reactive trajectories. Spectrograms of a reactive trajectory were obtained; these clearly showed the reactant, transient, and product regions, especially for the dehydrolation path.

  4. New serial time codes for seismic short period and long period data acquisition systems

    International Nuclear Information System (INIS)

    Kolvankar, V.G.; Rao, D.S.

    1988-01-01

    This paper discusses a new time code for time indexing multichannel short period (1 to 25 hz) seismic event data recorded on a single track of magnetic tape in digital format and discusses its usefulness in contrast to Vela time code used in continuous analog multichannel data recording system on multitrack instrumentation tape deck. This paper also discusses another time code, used for time indexing of seismic long period (DC to 2.5 seconds) multichannel data recorded on a single track of magnetic tape in digital format. The time code decoding and display system developed to provide quick access to any desired portion of the tape in both data recording and repro duce system is also discussed. (author). 7 figs

  5. Optimization of irradiation decay and counting times in nuclear activation analysis using short-lived nuclides

    International Nuclear Information System (INIS)

    Bjoernstad, T.

    This work describes a method and outlines a procedure for optim- ization of an activation analysis with respect to the experimental times, irradiation time, t(subi), decay time and counting time. The method is based on the 'minimum relative standard deviation criterion', and specially designed for the use on short-lived nuclides. A computer program, COMB1, is written in the BASIC language in order to make the calculations easier and faster. It is intended to be understandable, and easily applicable on a computer of modest size. Time and cost are important factors, especially for routine analysis on a service basis. In such cases one can often allow a controlled reduction in the analysis quality (through a higher relative standard deviation). The procedure outlined can therefore help find acceptable conditions by calculation of the 'best practical' (or reasonable) experimental time values, and the minimum number of accumulation cycles necessary to fulfil the requirements given. (Auth.)

  6. Short-Term Memory Loss Over Time Without Retroactive Stimulus Interference

    OpenAIRE

    Cowan, Nelson; AuBuchon, Angela M.

    2008-01-01

    A key question in cognitive psychology is whether information in short-term memory is lost as a function of time. Lewandowsky, Duncan, and Brown (2004) argued against that memory loss because forgetting in serial recall occurred to the same extent across serial positions regardless of the rate of recall. However, we believe Lewandowsky et al. only prevented one of two types of rehearsal; they did not prevent non-articulatory rehearsal via attention. To prevent articulatory and non-articulator...

  7. Thermonuclear Bursts with Short Recurrence Times from Neutron Stars Explained by Opacity-driven Convection

    Energy Technology Data Exchange (ETDEWEB)

    Keek, L. [X-ray Astrophysics Laboratory, Astrophysics Science Division, NASA/GSFC, Greenbelt, MD 20771 (United States); Heger, A., E-mail: laurens.keek@nasa.gov [Monash Center for Astrophysics, School of Physics and Astronomy, Monash University, Victoria, 3800 (Australia)

    2017-06-20

    Thermonuclear flashes of hydrogen and helium accreted onto neutron stars produce the frequently observed Type I X-ray bursts. It is the current paradigm that almost all material burns in a burst, after which it takes hours to accumulate fresh fuel for the next burst. In rare cases, however, bursts are observed with recurrence times as short as minutes. We present the first one-dimensional multi-zone simulations that reproduce this phenomenon. Bursts that ignite in a relatively hot neutron star envelope leave a substantial fraction of the fuel unburned at shallow depths. In the wake of the burst, convective mixing events driven by opacity bring this fuel down to the ignition depth on the observed timescale of minutes. There, unburned hydrogen mixes with the metal-rich ashes, igniting to produce a subsequent burst. We find burst pairs and triplets, similar to the observed instances. Our simulations reproduce the observed fraction of bursts with short waiting times of ∼30%, and demonstrate that short recurrence time bursts are typically less bright and of shorter duration.

  8. Quantifying complexity of financial short-term time series by composite multiscale entropy measure

    Science.gov (United States)

    Niu, Hongli; Wang, Jun

    2015-05-01

    It is significant to study the complexity of financial time series since the financial market is a complex evolved dynamic system. Multiscale entropy is a prevailing method used to quantify the complexity of a time series. Due to its less reliability of entropy estimation for short-term time series at large time scales, a modification method, the composite multiscale entropy, is applied to the financial market. To qualify its effectiveness, its applications in the synthetic white noise and 1 / f noise with different data lengths are reproduced first in the present paper. Then it is introduced for the first time to make a reliability test with two Chinese stock indices. After conducting on short-time return series, the CMSE method shows the advantages in reducing deviations of entropy estimation and demonstrates more stable and reliable results when compared with the conventional MSE algorithm. Finally, the composite multiscale entropy of six important stock indices from the world financial markets is investigated, and some useful and interesting empirical results are obtained.

  9. Time-frequency analysis of fusion plasma signals beyond the short-time Fourier transform paradigm: An overview

    International Nuclear Information System (INIS)

    Bizarro, Joao P.S.; Figueiredo, Antonio C.A.

    2008-01-01

    Performing a time-frequency (t-f) analysis on actual magnetic pick-up coil data from the JET tokamak, a comparison is presented between the spectrogram and the Wigner and Choi-Williams distributions. Whereas the former, which stems from the short-time Fourier transform and has been the work-horse for t-f signal processing, implies an unavoidable trade-off between time and frequency resolutions, the latter two belong to a later generation of distributions that yield better, if not optimal joint t-f localization. Topics addressed include signal representation in the t-f plane, frequency identification and evolution, instantaneous-frequency estimation, and amplitude tracking

  10. Short-Term Change Detection in Wetlands Using Sentinel-1 Time Series

    DEFF Research Database (Denmark)

    Muro, Javier; Canty, Morton; Conradsen, Knut

    2016-01-01

    Automated monitoring systems that can capture wetlands’ high spatial and temporal variability are essential for their management. SAR-based change detection approaches offer a great opportunity to enhance our understanding of complex and dynamic ecosystems. We test a recently-developed time serie...... certain landscape changes are detected only by either the Landsat-based or the S1-omnibus method. The S1-omnibus method shows a great potential for an automated monitoring of short time changes and accurate delineation of areas of high variability and of slow and gradual changes....

  11. Identification of the structure parameters using short-time non-stationary stochastic excitation

    Science.gov (United States)

    Jarczewska, Kamila; Koszela, Piotr; Śniady, PaweŁ; Korzec, Aleksandra

    2011-07-01

    In this paper, we propose an approach to the flexural stiffness or eigenvalue frequency identification of a linear structure using a non-stationary stochastic excitation process. The idea of the proposed approach lies within time domain input-output methods. The proposed method is based on transforming the dynamical problem into a static one by integrating the input and the output signals. The output signal is the structure reaction, i.e. structure displacements due to the short-time, irregular load of random type. The systems with single and multiple degrees of freedom, as well as continuous systems are considered.

  12. Performance evaluation of the short-time objective intelligibility measure with different band importance functions

    DEFF Research Database (Denmark)

    Heidemann Andersen, Asger; de Haan, Jan Mark; Tan, Zheng-Hua

    performance measures: root-mean-squared-error, Pearson correlation, and Kendall rank correlation. The results show substantially improved performance when fitting and evaluating on the same dataset. However, this advantage does not necessarily subsist when fitting and evaluating on different datasets. When...... with a filter bank, 2) envelopes are extracted from each band, 3) the temporal correlation between clean and degraded envelopes is computed in short time segments, and 4) the correlation is averaged across time and frequency bands to obtain the final output. An unusual choice in the design of the STOI measure...

  13. Spectrogram analysis of selected tremor signals using short-time Fourier transform and continuous wavelet transform

    Directory of Open Access Journals (Sweden)

    D. Seidl

    1999-06-01

    Full Text Available Among a variety of spectrogram methods Short-Time Fourier Transform (STFT and Continuous Wavelet Transform (CWT were selected to analyse transients in non-stationary tremor signals. Depending on the properties of the tremor signal a more suitable representation of the signal is gained by CWT. Three selected broadband tremor signals from the volcanos Mt. Stromboli, Mt. Semeru and Mt. Pinatubo were analyzed using both methods. The CWT can also be used to extend the definition of coherency into a time-varying coherency spectrogram. An example is given using array data from the volcano Mt. Stromboli.

  14. Automated Detection of Short Optical Transients of Astrophysical Origin in Real Time

    Directory of Open Access Journals (Sweden)

    Marcin Sokołowski

    2010-01-01

    Full Text Available The detection of short optical transients of astrophysical origin in real time is an important task for existing robotic telescopes. The faster a new optical transient is detected, the earlier follow-up observations can be started. The sooner the object is identified, the more data can be collected before the source fades away, particularly in the most interesting early period of the transient. In this the real-time pipeline designed for identification of optical flashes with the “Pi of the Sky” project will be presented in detail together with solutions used by other experiments.

  15. Elution of monomer from different bulk fill dental composite resins.

    Science.gov (United States)

    Cebe, Mehmet Ata; Cebe, Fatma; Cengiz, Mehmet Fatih; Cetin, Ali Rıza; Arpag, Osman Fatih; Ozturk, Bora

    2015-07-01

    The purpose of this study was to evaluate the elution of Bis-GMA, TEGDMA, HEMA, and Bis-EMA monomers from six bulk fill composite resins over four different time periods, using HPLC. Six different composite resin materials were used in the present study: Tetric Evo Ceram Bulk Fill (Ivoclar Vivadent, Amherst, NY), X-tra Fill (VOCO, Cuxhaven, Germany), Sonic Fill (Kerr, Orange, CA, USA), Filtek Bulk Fill (3M ESPE Dental Product, St. Paul, MN), SDR (Dentsply, Konstanz, Germany), EQUIA (GC America INC, Alsip, IL). The samples (4mm thickness, 5mm diameter) were prepared and polymerized for 20s with a light emitted diode unit. After fabrication, each sample was immediately immersed in 75wt% ethanol/water solution used as extraction fluid and stored in the amber colored bottles at room temperature. Ethanol/water samples were taken (0.5mL) at predefined time intervals:10m (T1), 1h (T2), 24h (T3) and 30 days (T4). These samples were analyzed by HPLC. The obtained data were analyzed with one-way ANOVA and Tukey HSD at significance level of pcomposites (pcomposite resins in all time periods and the amount of eluted monomers was increased with time. Copyright © 2015 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  16. A characterization of persistence at short times in the WFC3/IR detector

    Science.gov (United States)

    Gennaro, M.; Bajaj, V.; Long, K.

    2018-05-01

    Persistence in the WFC3/IR detector appears to decay as a power law as a function of time elapsed since the end of a stimulus. In this report we study departures from the power law at times shorter than a few hundreds seconds after the stimulus. In order to have better short-time cadence, we use the Multiaccum (.ima) files, which trace the accumulated charge in the pixels as function of time, rather than the final pipeline products (.flt files), which instead report the electron rate estimated via a linear fit to the accumulated charge vs. time relation. We note that at short times after the stimulus, the absolute change in persistence is the strongest, thus a linear fit to the accumulated signal (the .flt values) can be a poor representation of the strongly varying persistence signal. The already observed power-law decay of the persistence signal, still holds at shorter times, with typical values of the power law index, gamma in [-0.8,-1] for stimuli that saturate the WFC3 pixels. To a good degree of approximation, a single power law is a good fit to the persistence signal decay from 100 to 5000 seconds. We also detect a tapering-off in the power-law decay at increasingly shorter times. This change in behavior is of the order of Delta Gamma 0.02 - 0.05 when comparing power-law fits performed to the persistence signal from 0 up to 250 seconds and from 0 up to 4000 seconds after the stimulus, indicating that persistence decays slightly more rapidly as time progresses. Our results may suggest that for even shorter times, not probed by our study, the WFC3 persistence signal might deviate from a single power-law model.

  17. Adaptive synchrosqueezing based on a quilted short-time Fourier transform

    Science.gov (United States)

    Berrian, Alexander; Saito, Naoki

    2017-08-01

    In recent years, the synchrosqueezing transform (SST) has gained popularity as a method for the analysis of signals that can be broken down into multiple components determined by instantaneous amplitudes and phases. One such version of SST, based on the short-time Fourier transform (STFT), enables the sharpening of instantaneous frequency (IF) information derived from the STFT, as well as the separation of amplitude-phase components corresponding to distinct IF curves. However, this SST is limited by the time-frequency resolution of the underlying window function, and may not resolve signals exhibiting diverse time-frequency behaviors with sufficient accuracy. In this work, we develop a framework for an SST based on a "quilted" short-time Fourier transform (SST-QSTFT), which allows adaptation to signal behavior in separate time-frequency regions through the use of multiple windows. This motivates us to introduce a discrete reassignment frequency formula based on a finite difference of the phase spectrum, ensuring computational accuracy for a wider variety of windows. We develop a theoretical framework for the SST-QSTFT in both the continuous and the discrete settings, and describe an algorithm for the automatic selection of optimal windows depending on the region of interest. Using synthetic data, we demonstrate the superior numerical performance of SST-QSTFT relative to other SST methods in a noisy context. Finally, we apply SST-QSTFT to audio recordings of animal calls to demonstrate the potential of our method for the analysis of real bioacoustic signals.

  18. The loss of short-term visual representations over time: decay or temporal distinctiveness?

    Science.gov (United States)

    Mercer, Tom

    2014-12-01

    There has been much recent interest in the loss of visual short-term memories over the passage of time. According to decay theory, visual representations are gradually forgotten as time passes, reflecting a slow and steady distortion of the memory trace. However, this is controversial and decay effects can be explained in other ways. The present experiment aimed to reexamine the maintenance and loss of visual information over the short term. Decay and temporal distinctiveness models were tested using a delayed discrimination task, in which participants compared complex and novel objects over unfilled retention intervals of variable length. Experiment 1 found no significant change in the accuracy of visual memory from 2 to 6 s, but the gap separating trials reliably influenced task performance. Experiment 2 found evidence for information loss at a 10-s retention interval, but temporally separating trials restored the fidelity of visual memory, possibly because temporally isolated representations are distinct from older memory traces. In conclusion, visual representations lose accuracy at some point after 6 s, but only within temporally crowded contexts. These findings highlight the importance of temporal distinctiveness within visual short-term memory. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  19. [Clinical characteristics of short tear film breakup time (BUT) -type dry eye].

    Science.gov (United States)

    Yamamoto, Yuji; Yokoi, Norihiko; Higashihara, Hisayo; Inagaki, Kayoko; Sonomura, Yukiko; Komuro, Aoi; Kinoshita, Shigeru

    2012-12-01

    To evaluate the clinical characteristics and management of short tear film breakup time (BUT) -type dry eye. Clinical background and post-treatment changes of symptoms in 77 patients with short BUT -type dry eye were investigated. Treatment consisted of artificial-tear eye-drop instillation and, if necessary, the addition of a low-density-level steroid, hyaluronic acid, a low-density-level cyclopentolate prepared by ourselves and punctal plugs inserted into the upper and lower lacrimal puncta. There were three times more women than men among the patients, and the peak age of occurrence was in the twenties in the men and in the sixties in the women. Our findings show that visual display terminal (VDT) work, contact lens (CL) wear, and changes in the sex hormones may initiate subjective symptoms. Some patients had simultaneous conjunctivochalasis, allergic conjunctivitis, and meibomian gland dysfunction. Nineteen patients (24.7%) were effectively treated with eye-drop instillation alone. Thirty-seven patients (48.1%) required punctal-plug insertion, which was completely effective in only 8 of them (21.6%). Mainly young men and menopausal women contract short BUT -type dry eye. Changes in sex hormones, VDT work and CL wear may be causal, and the disease cannot be controlled by eyedrop and punctal-plug treatment alone.

  20. Research on resistance characteristics of YBCO tape under short-time DC large current impact

    Science.gov (United States)

    Zhang, Zhifeng; Yang, Jiabin; Qiu, Qingquan; Zhang, Guomin; Lin, Liangzhen

    2017-06-01

    Research of the resistance characteristics of YBCO tape under short-time DC large current impact is the foundation of the developing DC superconducting fault current limiter (SFCL) for voltage source converter-based high voltage direct current system (VSC-HVDC), which is one of the valid approaches to solve the problems of renewable energy integration. SFCL can limit DC short-circuit and enhance the interrupting capabilities of DC circuit breakers. In this paper, under short-time DC large current impacts, the resistance features of naked tape of YBCO tape are studied to find the resistance - temperature change rule and the maximum impact current. The influence of insulation for the resistance - temperature characteristics of YBCO tape is studied by comparison tests with naked tape and insulating tape in 77 K. The influence of operating temperature on the tape is also studied under subcooled liquid nitrogen condition. For the current impact security of YBCO tape, the critical current degradation and top temperature are analyzed and worked as judgment standards. The testing results is helpful for in developing SFCL in VSC-HVDC.

  1. Equivalence between short-time biphasic and incompressible elastic material responses.

    Science.gov (United States)

    Ateshian, Gerard A; Ellis, Benjamin J; Weiss, Jeffrey A

    2007-06-01

    Porous-permeable tissues have often been modeled using porous media theories such as the biphasic theory. This study examines the equivalence of the short-time biphasic and incompressible elastic responses for arbitrary deformations and constitutive relations from first principles. This equivalence is illustrated in problems of unconfined compression of a disk, and of articular contact under finite deformation, using two different constitutive relations for the solid matrix of cartilage, one of which accounts for the large disparity observed between the tensile and compressive moduli in this tissue. Demonstrating this equivalence under general conditions provides a rationale for using available finite element codes for incompressible elastic materials as a practical substitute for biphasic analyses, so long as only the short-time biphasic response is sought. In practice, an incompressible elastic analysis is representative of a biphasic analysis over the short-term response deltatelasticity tensor, and K is the hydraulic permeability tensor of the solid matrix. Certain notes of caution are provided with regard to implementation issues, particularly when finite element formulations of incompressible elasticity employ an uncoupled strain energy function consisting of additive deviatoric and volumetric components.

  2. Evaluation of skeletal muscle during exercise on short repetition time MR imaging

    International Nuclear Information System (INIS)

    Yoshioka, Hiroshi; Niitsu, Mamoru; Anno, Izumi; Takahashi, Hideyuki; Kuno, Shinya; Matsumoto, Kunihiko; Itai, Yuji

    1992-01-01

    There have been many reports on the effects of exercise on skeletal muscle signal intensities based on magnetic resonance (MR) imaging. These images were obtained using T 2 -weighted MR images. The purpose of this study was to observe muscles during exercise while shortening the repetition time (TR) on spin echo images. In addition, inactive and active muscles were differentiated in the same manner. T 2 values of the tibialis anterior m. were calculated from TR=400 ms to TR=3000 ms. These values were mostly constant and didn't depend upon TR. Increases in signal intensities of the exercise muscles could be observed on the short TR (600 ms) MR images since the changes of the signal intensities mainly depend upon T 2 values. Thus, the T 2 value is useful as a quantitative index to assess the exercise muscle even on the short TR MR images. (author)

  3. Nonlinear response of vessel walls due to short-time thermomechanical loading

    International Nuclear Information System (INIS)

    Pfeiffer, P.A.; Kulak, R.F.

    1994-01-01

    Maintaining structural integrity of the reactor pressure vessel (RPV) during a postulated core melt accident is an important safety consideration in the design of the vessel. This study addresses the failure predictions of the vessel due to thermal and pressure loadings fro the molten core debris depositing on the lower head of the vessel. Different loading combinations were considered based on the dead load, yield stress assumptions, material response and internal pressurization. The analyses considered only short term failure (quasi static) modes, long term failure modes were not considered. Short term failure modes include plastic instabilities of the structure and failure due to exceeding the failure strain. Long term failure odes would be caused by creep rupture that leads to plastic instability of the structure. Due to the sort time durations analyzed, creep was not considered in the analyses presented

  4. Short-term memory loss over time without retroactive stimulus interference.

    Science.gov (United States)

    Cowan, Nelson; AuBuchon, Angela M

    2008-02-01

    A key question in cognitive psychology is whether information in short-term memory is lost as a function of time. Lewandowsky, Duncan, and Brown (2004) argued against that memory loss because forgetting in serial recall occurred to the same extent across serial positions regardless of the rate of recall. However, we believe Lewandowsky et al. (2004) only prevented one of two types of rehearsal; they did not prevent nonarticulatory rehearsal via attention. To prevent articulatory and nonarticulatory rehearsal without introducing interference, we presented unevenly timed stimuli for serial recall and, on some trials, required that the timing of stimuli be reproduced in the response. In those trials only, evidence of memory loss over time emerged. Further research is needed to identify whether this memory loss is decay or lost distinctiveness.

  5. Micro-Doppler Ambiguity Resolution Based on Short-Time Compressed Sensing

    Directory of Open Access Journals (Sweden)

    Jing-bo Zhuang

    2015-01-01

    Full Text Available When using a long range radar (LRR to track a target with micromotion, the micro-Doppler embodied in the radar echoes may suffer from ambiguity problem. In this paper, we propose a novel method based on compressed sensing (CS to solve micro-Doppler ambiguity. According to the RIP requirement, a sparse probing pulse train with its transmitting time random is designed. After matched filtering, the slow-time echo signals of the micromotion target can be viewed as randomly sparse sampling of Doppler spectrum. Select several successive pulses to form a short-time window and the CS sensing matrix can be built according to the time stamps of these pulses. Then performing Orthogonal Matching Pursuit (OMP, the unambiguous micro-Doppler spectrum can be obtained. The proposed algorithm is verified using the echo signals generated according to the theoretical model and the signals with micro-Doppler signature produced using the commercial electromagnetic simulation software FEKO.

  6. Establishing conditions for the storage and elution of rabies virus RNA using FTA® cards

    Science.gov (United States)

    SAKAI, Takeo; ISHII, Ayako; SEGAWA, Takao; TAKAGI, Yukihiko; KOBAYASHI, Yuki; ITOU, Takuya

    2014-01-01

    The Flinders Technology Associates filter paper cards (FTA® cards) can be used to store nucleic acid from various samples and are easily portable. However, RNA is physicochemically unstable compared with DNA, and appropriate methods have not been established for storage and extraction of RNA from FTA® cards. The present study investigated the optimum conditions for storage and elution of viral RNA (vRNA) using rabies virus (RABV) applied to FTA® cards. When TE buffer was used, the elution rates of vRNA increased with the length of the elution time. When the cards were stored at −80°C or −20°C, vRNA was stable over 3 months. Degradation of vRNAs occurred following storage at 4°C and room temperature, suggesting that RNA should be extracted from cards as soon as possible if no freezer is available. When we tried to amplify vRNA from RABV-infected animal brains applied to FTA® cards and stored at −80°C for 6 months, we did not detect any amplified products with the primer set for 964 bp of RABV N gene. However, we were able to detect amplified products by increasing the elution time of vRNA from FTA® cards from 30 min to 24 hr or by changing the primer sets to amplify 290 bp of N gene. Thus, we recommend extending the elution time for damaged or low concentration samples in FTA® cards. PMID:25648208

  7. Innovative Elution Processes for Recovering Uranium from Seawater

    International Nuclear Information System (INIS)

    Wai, Chien; Tian, Guoxin; Janke, Christopher

    2014-01-01

    Utilizing amidoxime-based polymer sorbents for extraction of uranium from seawater has attracted considerable interest in recent years. Uranium collected in the sorbent is recovered typically by elution with an acid. One drawback of acid elution is deterioration of the sorbent which is a significant factor that limits the economic competitiveness of the amidoxime-based sorbent systems for sequestering uranium from seawater. Developing innovative elution processes to improve efficiency and to minimize loss of sorbent capacity become essential in order to make this technology economically feasible for large-scale industrial applications. This project has evaluated several elution processes including acid elution, carbonate elution, and supercritical fluid elution for recovering uranium from amidoxime-based polymer sorbents. The elution efficiency, durability and sorbent regeneration for repeated uranium adsorption- desorption cycles in simulated seawater have been studied. Spectroscopic techniques are used to evaluate chemical nature of the sorbent before and after elution. A sodium carbonate-hydrogen peroxide elution process for effective removal of uranium from amidoxime-based sorbent is developed. The cause of this sodium carbonate and hydrogen peroxide synergistic leaching of uranium from amidoxime-based sorbent is attributed to the formation of an extremely stable uranyl peroxo-carbonato complex. The efficiency of uranium elution by the carbonate-hydrogen peroxide method is comparable to that of the hydrochloric acid elution but damage to the sorbent material is much less for the former. The carbonate- hydrogen peroxide elution also does not need any elaborate step to regenerate the sorbent as those required for hydrochloric acid leaching. Several CO2-soluble ligands have been tested for extraction of uranium from the sorbent in supercritical fluid carbon dioxide. A mixture of hexafluoroacetylacetone and tri-n-butylphosphate shows the best result but uranium

  8. Innovative Elution Processes for Recovering Uranium from Seawater

    Energy Technology Data Exchange (ETDEWEB)

    Wai, Chien [Univ. of Idaho, Moscow, ID (United States); Tian, Guoxin [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Janke, Christopher [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2014-05-29

    Utilizing amidoxime-based polymer sorbents for extraction of uranium from seawater has attracted considerable interest in recent years. Uranium collected in the sorbent is recovered typically by elution with an acid. One drawback of acid elution is deterioration of the sorbent which is a significant factor that limits the economic competitiveness of the amidoxime-based sorbent systems for sequestering uranium from seawater. Developing innovative elution processes to improve efficiency and to minimize loss of sorbent capacity become essential in order to make this technology economically feasible for large-scale industrial applications. This project has evaluated several elution processes including acid elution, carbonate elution, and supercritical fluid elution for recovering uranium from amidoxime-based polymer sorbents. The elution efficiency, durability and sorbent regeneration for repeated uranium adsorption- desorption cycles in simulated seawater have been studied. Spectroscopic techniques are used to evaluate chemical nature of the sorbent before and after elution. A sodium carbonate-hydrogen peroxide elution process for effective removal of uranium from amidoxime-based sorbent is developed. The cause of this sodium carbonate and hydrogen peroxide synergistic leaching of uranium from amidoxime-based sorbent is attributed to the formation of an extremely stable uranyl peroxo-carbonato complex. The efficiency of uranium elution by the carbonate-hydrogen peroxide method is comparable to that of the hydrochloric acid elution but damage to the sorbent material is much less for the former. The carbonate- hydrogen peroxide elution also does not need any elaborate step to regenerate the sorbent as those required for hydrochloric acid leaching. Several CO2-soluble ligands have been tested for extraction of uranium from the sorbent in supercritical fluid carbon dioxide. A mixture of hexafluoroacetylacetone and tri-n-butylphosphate shows the best result but uranium

  9. Analysis of Seasonal Signal in GPS Short-Baseline Time Series

    Science.gov (United States)

    Wang, Kaihua; Jiang, Weiping; Chen, Hua; An, Xiangdong; Zhou, Xiaohui; Yuan, Peng; Chen, Qusen

    2018-04-01

    Proper modeling of seasonal signals and their quantitative analysis are of interest in geoscience applications, which are based on position time series of permanent GPS stations. Seasonal signals in GPS short-baseline (paper, to better understand the seasonal signal in GPS short-baseline time series, we adopted and processed six different short-baselines with data span that varies from 2 to 14 years and baseline length that varies from 6 to 1100 m. To avoid seasonal signals that are overwhelmed by noise, each of the station pairs is chosen with significant differences in their height (> 5 m) or type of the monument. For comparison, we also processed an approximately zero baseline with a distance of pass-filtered (BP) noise is valid for approximately 40% of the baseline components, and another 20% of the components can be best modeled by a combination of the first-order Gauss-Markov (FOGM) process plus white noise (WN). The TEM displacements are then modeled by considering the monument height of the building structure beneath the GPS antenna. The median contributions of TEM to the annual amplitude in the vertical direction are 84% and 46% with and without additional parts of the monument, respectively. Obvious annual signals with amplitude > 0.4 mm in the horizontal direction are observed in five short-baselines, and the amplitudes exceed 1 mm in four of them. These horizontal seasonal signals are likely related to the propagation of daily/sub-daily TEM displacement or other signals related to the site environment. Mismodeling of the tropospheric delay may also introduce spurious seasonal signals with annual amplitudes of 5 and 2 mm, respectively, for two short-baselines with elevation differences greater than 100 m. The results suggest that the monument height of the additional part of a typical GPS station should be considered when estimating the TEM displacement and that the tropospheric delay should be modeled cautiously, especially with station pairs with

  10. High-affinity RNA aptamers to C-reactive protein (CRP): newly developed pre-elution methods for aptamer selection

    International Nuclear Information System (INIS)

    Orito, N; Umekage, S; Sakai, E; Tanaka, T; Kikuchi, Y; Sato, K; Kawauchi, S; Tanaka, H

    2012-01-01

    We have developed a modified SELEX (systematic evolution of ligands by exponential enrichment) method to obtain RNA aptamers with high affinity to C-reactive protein (CRP). CRP is a clinical biomarker present in plasma, the level of which increases in response to infections and noninfectious inflammation. The CRP level is also an important prognostic indicator in patients with several syndromes. At present, CRP content in blood is measured immunochemically using antibodies. To develop a more sensitive method using RNA aptamers, we have attempted to obtain high-affinity RNA aptamers to CRP. We succeeded in obtaining an RNA aptamer with high affinity to CRP using a CRP-immobilized Sepharose column and pre-elution procedure. Pre-elution is a method that removes the weak binding portion from a selected RNA population by washing for a short time with buffer containing CRP. By surface plasmon-resonance (SPR) analysis, the affinity constant of this aptamer for CRP was calculated to be K D = 2.25x10 -9 (M). The secondary structure, contact sites with CRP protein, and application of this aptamer will be described.

  11. Short-term wind power forecasting: probabilistic and space-time aspects

    DEFF Research Database (Denmark)

    Tastu, Julija

    work deals with the proposal and evaluation of new mathematical models and forecasting methods for short-term wind power forecasting, accounting for space-time dynamics based on geographically distributed information. Different forms of power predictions are considered, starting from traditional point...... into the corresponding models are analysed. As a final step, emphasis is placed on generating space-time trajectories: this calls for the prediction of joint multivariate predictive densities describing wind power generation at a number of distributed locations and for a number of successive lead times. In addition......Optimal integration of wind energy into power systems calls for high quality wind power predictions. State-of-the-art forecasting systems typically provide forecasts for every location individually, without taking into account information coming from the neighbouring territories. It is however...

  12. Short-time beta grain growth kinetics for a conventional titanium alloy

    International Nuclear Information System (INIS)

    Semiatin, S.L.; Sukonnik, I.M.

    1996-01-01

    The kinetics of beta grain growth during short-time, supertransus heat treatment of Ti-5Al-4V were determined using a salt-pot technique. The finite-time, subtransus temperature transient during salt-pot heating was quantified through measurements of the heat transfer coefficient characterizing conduction across the salt-titanium interface and a simple heat conduction analysis which incorporated this heat transfer coefficient. Grain size versus time data adjusted to account for the subtransus temperature transient were successfully fit to the parabolic grain growth law d n - d 0 n = kt exp(-Q/RT) using an exponent n equal to 2.0. Comparison of the present results to rapid, continuous heat treatment data in the literature for a similar titanium alloy revealed a number of semi-quantitative similarities

  13. Response probability and response time: a straight line, the Tagging/Retagging interpretation of short term memory, an operational definition of meaningfulness and short term memory time decay and search time.

    Science.gov (United States)

    Tarnow, Eugen

    2008-12-01

    The functional relationship between correct response probability and response time is investigated in data sets from Rubin, Hinton and Wenzel, J Exp Psychol Learn Mem Cogn 25:1161-1176, 1999 and Anderson, J Exp Psychol [Hum Learn] 7:326-343, 1981. The two measures are linearly related through stimulus presentation lags from 0 to 594 s in the former experiment and for repeated learning of words in the latter. The Tagging/Retagging interpretation of short term memory is introduced to explain this linear relationship. At stimulus presentation the words are tagged. This tagging level drops slowly with time. When a probe word is reintroduced the tagging level has to increase for the word to be properly identified leading to a delay in response time. The tagging time is related to the meaningfulness of the words used-the more meaningful the word the longer the tagging time. After stimulus presentation the tagging level drops in a logarithmic fashion to 50% after 10 s and to 20% after 240 s. The incorrect recall and recognition times saturate in the Rubin et al. data set (they are not linear for large time lags), suggesting a limited time to search the short term memory structure: the search time for recall of unusual words is 1.7 s. For recognition of nonsense words the corresponding time is about 0.4 s, similar to the 0.243 s found in Cavanagh (1972).

  14. Short- and long-run time-of-use price elasticities in Swiss residential electricity demand

    International Nuclear Information System (INIS)

    Filippini, Massimo

    2011-01-01

    This paper presents an empirical analysis on the residential demand for electricity by time-of-day. This analysis has been performed using aggregate data at the city level for 22 Swiss cities for the period 2000-2006. For this purpose, we estimated two log-log demand equations for peak and off-peak electricity consumption using static and dynamic partial adjustment approaches. These demand functions were estimated using several econometric approaches for panel data, for example LSDV and RE for static models, and LSDV and corrected LSDV estimators for dynamic models. The attempt of this empirical analysis has been to highlight some of the characteristics of the Swiss residential electricity demand. The estimated short-run own price elasticities are lower than 1, whereas in the long-run these values are higher than 1. The estimated short-run and long-run cross-price elasticities are positive. This result shows that peak and off-peak electricity are substitutes. In this context, time differentiated prices should provide an economic incentive to customers so that they can modify consumption patterns by reducing peak demand and shifting electricity consumption from peak to off-peak periods. - Highlights: → Empirical analysis on the residential demand for electricity by time-of-day. → Estimators for dynamic panel data. → Peak and off-peak residential electricity are substitutes.

  15. Study of surfaces and surface layers on high temperature materials after short-time thermal loads

    International Nuclear Information System (INIS)

    Bolt, H.; Hoven, H.; Koizlik, K.; Linke, J.; Nickel, H.; Wallura, E.

    1985-11-01

    Being part of the plasma-wall interaction during TOKAMAK operation, erosion- and redeposition processes of First Wall materials substantially influence plasma parameters as well as the properties of the First Wall. An important redeposition process of eroded material is the formation of thin films by atomic condensation. Examinations of First Wall components after TOKAMAK operation lead to the assumption that these thin metallic films tend to agglomerate to small particles under subsequent heat load. In laboratory experiments it is shown that thin metallic films on various substrates can agglomerate under short time high heat fluxes and also under longer lasting lower thermal loads, thus verifying the ''agglomeration hypothesis''. (orig.) [de

  16. A Statistical and Spectral Model for Representing Noisy Sounds with Short-Time Sinusoids

    Directory of Open Access Journals (Sweden)

    Myriam Desainte-Catherine

    2005-07-01

    Full Text Available We propose an original model for noise analysis, transformation, and synthesis: the CNSS model. Noisy sounds are represented with short-time sinusoids whose frequencies and phases are random variables. This spectral and statistical model represents information about the spectral density of frequencies. This perceptually relevant property is modeled by three mathematical parameters that define the distribution of the frequencies. This model also represents the spectral envelope. The mathematical parameters are defined and the analysis algorithms to extract these parameters from sounds are introduced. Then algorithms for generating sounds from the parameters of the model are presented. Applications of this model include tools for composers, psychoacoustic experiments, and pedagogy.

  17. Quantum Dynamics with Short-Time Trajectories and Minimal Adaptive Basis Sets.

    Science.gov (United States)

    Saller, Maximilian A C; Habershon, Scott

    2017-07-11

    Methods for solving the time-dependent Schrödinger equation via basis set expansion of the wave function can generally be categorized as having either static (time-independent) or dynamic (time-dependent) basis functions. We have recently introduced an alternative simulation approach which represents a middle road between these two extremes, employing dynamic (classical-like) trajectories to create a static basis set of Gaussian wavepackets in regions of phase-space relevant to future propagation of the wave function [J. Chem. Theory Comput., 11, 8 (2015)]. Here, we propose and test a modification of our methodology which aims to reduce the size of basis sets generated in our original scheme. In particular, we employ short-time classical trajectories to continuously generate new basis functions for short-time quantum propagation of the wave function; to avoid the continued growth of the basis set describing the time-dependent wave function, we employ Matching Pursuit to periodically minimize the number of basis functions required to accurately describe the wave function. Overall, this approach generates a basis set which is adapted to evolution of the wave function while also being as small as possible. In applications to challenging benchmark problems, namely a 4-dimensional model of photoexcited pyrazine and three different double-well tunnelling problems, we find that our new scheme enables accurate wave function propagation with basis sets which are around an order-of-magnitude smaller than our original trajectory-guided basis set methodology, highlighting the benefits of adaptive strategies for wave function propagation.

  18. Road Short-Term Travel Time Prediction Method Based on Flow Spatial Distribution and the Relations

    Directory of Open Access Journals (Sweden)

    Mingjun Deng

    2016-01-01

    Full Text Available There are many short-term road travel time forecasting studies based on time series, but indeed, road travel time not only relies on the historical travel time series, but also depends on the road and its adjacent sections history flow. However, few studies have considered that. This paper is based on the correlation of flow spatial distribution and the road travel time series, applying nearest neighbor and nonparametric regression method to build a forecasting model. In aspect of spatial nearest neighbor search, three different space distances are defined. In addition, two forecasting functions are introduced: one combines the forecasting value by mean weight and the other uses the reciprocal of nearest neighbors distance as combined weight. Three different distances are applied in nearest neighbor search, which apply to the two forecasting functions. For travel time series, the nearest neighbor and nonparametric regression are applied too. Then minimizing forecast error variance is utilized as an objective to establish the combination model. The empirical results show that the combination model can improve the forecast performance obviously. Besides, the experimental results of the evaluation for the computational complexity show that the proposed method can satisfy the real-time requirement.

  19. Mining biological information from 3D short time-series gene expression data: the OPTricluster algorithm.

    Science.gov (United States)

    Tchagang, Alain B; Phan, Sieu; Famili, Fazel; Shearer, Heather; Fobert, Pierre; Huang, Yi; Zou, Jitao; Huang, Daiqing; Cutler, Adrian; Liu, Ziying; Pan, Youlian

    2012-04-04

    Nowadays, it is possible to collect expression levels of a set of genes from a set of biological samples during a series of time points. Such data have three dimensions: gene-sample-time (GST). Thus they are called 3D microarray gene expression data. To take advantage of the 3D data collected, and to fully understand the biological knowledge hidden in the GST data, novel subspace clustering algorithms have to be developed to effectively address the biological problem in the corresponding space. We developed a subspace clustering algorithm called Order Preserving Triclustering (OPTricluster), for 3D short time-series data mining. OPTricluster is able to identify 3D clusters with coherent evolution from a given 3D dataset using a combinatorial approach on the sample dimension, and the order preserving (OP) concept on the time dimension. The fusion of the two methodologies allows one to study similarities and differences between samples in terms of their temporal expression profile. OPTricluster has been successfully applied to four case studies: immune response in mice infected by malaria (Plasmodium chabaudi), systemic acquired resistance in Arabidopsis thaliana, similarities and differences between inner and outer cotyledon in Brassica napus during seed development, and to Brassica napus whole seed development. These studies showed that OPTricluster is robust to noise and is able to detect the similarities and differences between biological samples. Our analysis showed that OPTricluster generally outperforms other well known clustering algorithms such as the TRICLUSTER, gTRICLUSTER and K-means; it is robust to noise and can effectively mine the biological knowledge hidden in the 3D short time-series gene expression data.

  20. Measurement of radon-222 concentration in environment sampled within short time using charcoal detector

    International Nuclear Information System (INIS)

    Yamasaki, Tadashi; Sekiyama, Shigenobu; Tokin, Mina; Nakayasu, Yumiko; Watanabe, Tamaki.

    1994-01-01

    The concentration of 222 Rn in air sampled within a very short period of time was measured using activated charcoal as the adsorber. The detector is the plastic canister containing mixture of the activated charcoal and the silica gel. The radon gas was adsorbed in the charcoal in the radon chamber at the temperature of 25degC. A little amount of liquid scintillation cocktail was added into the vial of liquid scintillation counter with the canister. The radon in the charcoal was extracted in the liquid scintillation cocktail. Alpha particles emitted from radon and its daughter nuclei in the cocktail were detected using the liquid scintillation counter. Present method has advantages of not only short sampling time of air but also adsorption of radon in charcoal under a constant temperature. The concentration of radon in air down to 2 Bq/m 3 could be detected. A kinetic model for adsorption of radon in the charcoal is also presented. The ratio of radon concentration in the charcoal to that in air under the equilibrium state of adsorption was estimated to be from 6.1 to 6.8 m 3 /kg at the temperature of 25degC. (author)

  1. Effective description of the short-time dynamics in open quantum systems

    Science.gov (United States)

    Rossi, Matteo A. C.; Foti, Caterina; Cuccoli, Alessandro; Trapani, Jacopo; Verrucchi, Paola; Paris, Matteo G. A.

    2017-09-01

    We address the dynamics of a bosonic system coupled to either a bosonic or a magnetic environment and derive a set of sufficient conditions that allow one to describe the dynamics in terms of the effective interaction with a classical fluctuating field. We find that for short interaction times the dynamics of the open system is described by a Gaussian noise map for several different interaction models and independently on the temperature of the environment. In order to go beyond a qualitative understanding of the origin and physical meaning of the above short-time constraint, we take a general viewpoint and, based on an algebraic approach, suggest that any quantum environment can be described by classical fields whenever global symmetries lead to the definition of environmental operators that remain well defined when increasing the size, i.e., the number of dynamical variables, of the environment. In the case of the bosonic environment this statement is exactly demonstrated via a constructive procedure that explicitly shows why a large number of environmental dynamical variables and, necessarily, global symmetries, entail the set of conditions derived in the first part of the work.

  2. FREQUENCY COMPONENT EXTRACTION OF HEARTBEAT CUES WITH SHORT TIME FOURIER TRANSFORM (STFT

    Directory of Open Access Journals (Sweden)

    Sumarna Sumarna

    2017-01-01

      Electro-acoustic human heartbeat detector have been made with the main parts : (a stetoscope (piece chest, (b mic condenser, (c transistor amplifier, and (d cues analysis program with MATLAB. The frequency components that contained in heartbeat. cues have also been extracted with Short Time Fourier Transform (STFT from 9 volunteers. The results of the analysis showed that heart rate appeared in every cue frequency spectrum with their harmony. The steps of the research were including detector instrument design, test and instrument repair, cues heartbeat recording with Sound Forge 10 program and stored in wav file ; cues breaking at the start and the end, and extraction/cues analysis using MATLAB. The MATLAB program included filter (bandpass filter with bandwidth between 0.01 – 110 Hz, cues breaking with hamming window and every part was calculated using Fourier Transform (STFT mechanism and the result were shown in frequency spectrum graph.   Keywords: frequency components extraction, heartbeat cues, Short Time Fourier Transform

  3. New solutions for the short-time analysis of geothermal vertical boreholes

    Energy Technology Data Exchange (ETDEWEB)

    Lamarche, Louis; Beauchamp, Benoit [Ecole de Technologie Supereure, 1100 Notre-Dame Ouest, Montreal (Canada)

    2007-04-15

    Many models, either numerical or analytical, have been proposed to analyse the thermal response of vertical heat exchangers that are used in ground coupled heat pump systems (GCHP). In both approaches, most of the models are valid after few hours of operation since they neglect the heat capacity of the borehole. This is valid for design purposes, where the time of interest is in the order of months and years. Recently, the short time response of vertical boreholes became a subject of interest. In this paper, we present a new analytical approach to treat this problem. It solves the exact solution for concentric cylinders and is a good approximation for the familiar U-tube configuration. (author)

  4. Spatial filtering velocimetry revisited: exact short-time detecting schemes from arbitrarily small-size reticles

    International Nuclear Information System (INIS)

    Ando, S; Nara, T; Kurihara, T

    2014-01-01

    Spatial filtering velocimetry was proposed in 1963 by Ator as a velocity-sensing technique for aerial camera-control systems. The total intensity of a moving surface is observed through a set of parallel-slit reticles, resulting in a narrow-band temporal signal whose frequency is directly proportional to the image velocity. However, even despite its historical importance and inherent technical advantages, the mathematical formulation of this technique is only valid when infinite-length observation in both space and time is possible, which causes significant errors in most applications where a small receptive window and high resolution in both axes are desired. In this study, we apply a novel mathematical technique, the weighted integral method, to solve this problem, and obtain exact sensing schemes and algorithms for finite (arbitrarily small but non-zero) size reticles and short-time estimation. Practical considerations for utilizing these schemes are also explored both theoretically and experimentally. (paper)

  5. Verification of short lead time forecast models: applied to Kp and Dst forecasting

    Science.gov (United States)

    Wintoft, Peter; Wik, Magnus

    2016-04-01

    In the ongoing EU/H2020 project PROGRESS models that predicts Kp, Dst, and AE from L1 solar wind data will be used as inputs to radiation belt models. The possible lead times from L1 measurements are shorter (10s of minutes to hours) than the typical duration of the physical phenomena that should be forecast. Under these circumstances several metrics fail to single out trivial cases, such as persistence. In this work we explore metrics and approaches for short lead time forecasts. We apply these to current Kp and Dst forecast models. This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 637302.

  6. Critical dynamics of the Potts model: short-time Monte Carlo simulations

    International Nuclear Information System (INIS)

    Silva, Roberto da; Drugowich de Felicio, J.R.

    2004-01-01

    We calculate the new dynamic exponent θ of the 4-state Potts model, using short-time simulations. Our estimates θ1=-0.0471(33) and θ2=-0.0429(11) obtained by following the behavior of the magnetization or measuring the evolution of the time correlation function of the magnetization corroborate the conjecture by Okano et al. [Nucl. Phys. B 485 (1997) 727]. In addition, these values agree with previous estimate of the same dynamic exponent for the two-dimensional Ising model with three-spin interactions in one direction, that is known to belong to the same universality class as the 4-state Potts model. The anomalous dimension of initial magnetization x0=zθ+β/ν is calculated by an alternative way that mixes two different initial conditions. We have also estimated the values of the static exponents β and ν. They are in complete agreement with the pertinent results of the literature

  7. Burn-up measurements of LEU fuel for short cooling times

    International Nuclear Information System (INIS)

    Pereda B, C.; Henriquez A, C.; Klein D, J.; Medel R, J.

    2005-01-01

    The measurements presented in this work were made essentially at in-pool gamma-spectrometric facility, installed inside of the secondary pool of the RECH-1 research reactor, where the measured fuel elements are under 2 meters of water. The main reason for using the in-pool facility was because of its capability to measure the burning of fuel elements without having to wait so long, that is with only 5 cooling days, which are the usual times between reactor operations. Regarding these short cooling times, this work confirms again the possibility of using the 95 Zr as a promising burnup monitor, in spite of the rough approximations used to do it. These results are statistically reasonable within the range calculated using codes. The work corroborates previous results, presented in Santiago de Chile, and it suggests future improvements in that way. (author)

  8. Optimal filtering of dynamics in short-time features for music organization

    DEFF Research Database (Denmark)

    Arenas-García, Jerónimo; Larsen, Jan; Hansen, Lars Kai

    2006-01-01

    There is an increasing interest in customizable methods for organizing music collections. Relevant music characterization can be obtained from short-time features, but it is not obvious how to combine them to get useful information. In this work, a novel method, denoted as the Positive Constrained...... Orthonormalized Partial Least Squares (POPLS), is proposed. Working on the periodograms of MFCCs time series, this supervised method finds optimal filters which pick up the most discriminative temporal information for any music organization task. Two examples are presented in the paper, the first being a simple...... proof-of-concept, where an altosax with and without vibrato is modelled. A more complex \\$11\\$ music genre classification setup is also investigated to illustrate the robustness and validity of the proposed method on larger datasets. Both experiments showed the good properties of our method, as well...

  9. Measurement and deconvolution of detector response time for short HPM pulses: Part 1, Microwave diodes

    International Nuclear Information System (INIS)

    Bolton, P.R.

    1987-06-01

    A technique is described for measuring and deconvolving response times of microwave diode detection systems in order to generate corrected input signals typical of an infinite detection rate. The method has been applied to cases of 2.86 GHz ultra-short HPM pulse detection where pulse rise time is comparable to that of the detector; whereas, the duration of a few nanoseconds is significantly longer. Results are specified in terms of the enhancement of equivalent deconvolved input voltages for given observed voltages. The convolution integral imposes the constraint of linear detector response to input power levels. This is physically equivalent to the conservation of integrated pulse energy in the deconvolution process. The applicable dynamic range of a microwave diode is therefore limited to a smaller signal region as determined by its calibration

  10. Transarterial chemoembolization with drug-eluting beads in hepatocellular carcinoma

    Science.gov (United States)

    Nam, Hee Chul; Jang, Bohyun; Song, Myeong Jun

    2016-01-01

    Transarterial chemoembolization (TACE) is a widely used standard treatment for patients with hepatocellular carcinoma (HCC) who are not suitable candidates for curative treatments. The rationale for TACE is that intra-arterial chemotherapy using lipiodol and chemotherapeutic agents, followed by selective vascular embolization, results in a strong cytotoxic effect as well as ischemia (conventional TACE). Recently, drug-eluting beads (DC Beads®) have been developed for transcatheter treatment of HCC to deliver higher doses of the chemotherapeutic agent and to prolong contact time with the tumor. DC Beads® can actively sequester doxorubicin hydrochloride from solution and release it in a controlled sustained fashion. Treatment with DC Beads® substantially reduced the amount of chemotherapeutic agent that reached the systemic circulation compared with conventional, lipiodol-based regimens, significantly reducing drug-related adverse events. In this article, we describe the treatment response, survival, and safety of TACE used with drug-eluting beads for the treatment of HCC and discuss future therapeutic possibilities. PMID:27833376

  11. Dynamics of silver elution from functionalised antimicrobial nanofiltration membranes.

    Science.gov (United States)

    Choudhari, S; Habimana, O; Hannon, J; Allen, A; Cummins, E; Casey, E

    2017-07-01

    In an effort to mitigate biofouling on thin film composite membranes such as nanofiltration and reverse osmosis, a myriad of different surface modification strategies has been published. The use of silver nanoparticles (Ag-NPs) has emerged as being particularly promising. Nevertheless, the stability of these surface modifications is still poorly understood, particularly under permeate flux conditions. Leaching or elution of Ag-NPs from the membrane surface can not only affect the antimicrobial characteristics of the membrane, but could also potentially present an environmental liability when applied in industrial-scale systems. This study sought to investigate the dynamics of silver elution and the bactericidal effect of an Ag-NP functionalised NF270 membrane. Inductively coupled plasma-atomic emission spectroscopy was used to show that the bulk of leached silver occurred at the start of experimental runs, and was found to be independent of salt or permeate conditions used. Cumulative amounts of leached silver did, however, stabilise following the initial release, and were shown to have maintained the biocidal characteristics of the modified membrane, as observed by a higher fraction of structurally damaged Pseudomonas fluorescens cells. These results highlight the need to comprehensively assess the time-dependent nature of bactericidal membranes.

  12. Short version of the Zimbardo Time Perspective Inventory (ZTPI-short) with and without the Future-Negative scale, verified on nationally representative samples

    Czech Academy of Sciences Publication Activity Database

    Košťál, Jaroslav; Klicperová-Baker, Martina; Lukavská, K.; Lukavský, Jiří

    2016-01-01

    Roč. 25, č. 2 (2016), s. 169-192 ISSN 0961-463X Institutional support: RVO:68081740 Keywords : ZTPI * ZTPI-short * time perspective * temporal orientation * representative sample Subject RIV: AN - Psychology Impact factor: 1.206, year: 2016

  13. EXPLORING THE POTENTIAL OF SHORT-TIME FOURIER TRANSFORMS FOR ANALYZING SKIN CONDUCTANCE AND PUPILLOMETRY IN REAL-TIME APPLICATIONS

    International Nuclear Information System (INIS)

    Roger Lew; Brian P. Dyre; Steffen Werner; Jeffrey C. Joe; Brian Wotring; Tuan Tran

    2008-01-01

    The development of real-time predictors of mental workload is critical for the practical application of augmented cognition to human-machine systems. This paper explores a novel method based on a short-time Fourier transform (STFT) for analyzing galvanic skin conductance (SC) and pupillometry time-series data to extract estimates of mental workload with temporal bandwidth high-enough to be useful for augmented cognition applications. We tested the method in the context of a process control task based on the DURESS simulation developed by Vincente and Pawlak (1994; ported to Java by Cosentino, and Ross, 1999). SC, pupil dilation, blink rate, and visual scanning patterns were measured for four participants actively engaged in controlling the simulation. Fault events were introduced that required participants to diagnose errors and make control adjustments to keep the simulator operating within a target range. We were interested in whether the STFT of these measures would produce visible effects of the increase in mental workload and stress associated with these events. Graphical exploratory data analysis of the STFT showed visible increases in the power spectrum across a range of frequencies directly following fault events. We believe this approach shows potential as a relatively unobtrusive, low-cost, high bandwidth measure of mental workload that could be particularly useful for the application of augmented cognition to human-machine systems

  14. EXPLORING THE POTENTIAL OF SHORT-TIME FOURIER TRANSFORMS FOR ANALYZING SKIN CONDUCTANCE AND PUPILLOMETRY IN REAL-TIME APPLICATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Roger Lew; Brian P. Dyre; Steffen Werner; Jeffrey C. Joe; Brian Wotring; Tuan Tran

    2008-09-01

    The development of real-time predictors of mental workload is critical for the practical application of augmented cognition to human-machine systems. This paper explores a novel method based on a short-time Fourier transform (STFT) for analyzing galvanic skin conductance (SC) and pupillometry time-series data to extract estimates of mental workload with temporal bandwidth high-enough to be useful for augmented cognition applications. We tested the method in the context of a process control task based on the DURESS simulation developed by Vincente and Pawlak (1994; ported to Java by Cosentino,& Ross, 1999). SC, pupil dilation, blink rate, and visual scanning patterns were measured for four participants actively engaged in controlling the simulation. Fault events were introduced that required participants to diagnose errors and make control adjustments to keep the simulator operating within a target range. We were interested in whether the STFT of these measures would produce visible effects of the increase in mental workload and stress associated with these events. Graphical exploratory data analysis of the STFT showed visible increases in the power spectrum across a range of frequencies directly following fault events. We believe this approach shows potential as a relatively unobtrusive, low-cost, high bandwidth measure of mental workload that could be particularly useful for the application of augmented cognition to human-machine systems.

  15. Elution of Artificial Sputum from Swab by Rotating Magnetic Field-Induced Mechanical Impingement

    Directory of Open Access Journals (Sweden)

    Shubham Banik

    2017-12-01

    Full Text Available Cotton-tipped applicator swabs are used as a collection device for many biological samples and its complete elution is a desired step for clinical and forensic diagnostics. Swabs are used to collect infectious body fluids, where the concentration of pathogens can range from 1 × 104 CFU/mL (colony forming units/mL in respiratory-tract infections and 1 × 105 in urinary-tract infections, to up to 1 × 109 CFU/mL in salivary samples. These samples are then eluted and lysed, prior to DNA (De-oxy Ribonucleic Acid analysis. The recovery of micro-organisms from a matrix of swab fibres depends on the nature of the body fluid, the type of the swab fibres, and the process of elution. Various methods to elute samples from swab include chemical digestion of fibres (~20% recovery, centrifugation (~58% recovery, piezoelectric vibration, or pressurized fluid-flow (~60% recovery. This study reports a magnetically-actuated physical impingement method for elution and recovery of artificial sputum samples from cotton fibres. A device has been fabricated to induce a rotating magnetic field on smaller magnetic particles in a vial that strikes the swab within a confined gap. Elution from the swab in this device was characterized using 2% Methyl cellulose in deionised water, loaded with fluorescent-tagged polystyrene beads and E. coli at various concentrations. The recovery efficiency was found to increase with both rotational speed and elution time, but plateaus after 400 RPM (Revolutions per minute and 120 s, respectively. At a higher concentration of polystyrene beads (5 × 108 particles/mL, a maximum recovery of ~85% was achieved. With lower concentration, (1 × 105 particles/mL the maximum efficiency (~92.8% was found to be almost twice of passive elution (46.7%. In the case of E. coli, the corresponding recovery efficiency at 3.35 × 105 CFU/mL is 90.4% at 500 RPM and 120 s. This elution method is expected to have a wide applicability in clinical diagnostics.

  16. Photoluminescence decay dynamics in γ-Ga2O3 nanocrystals: The role of exclusion distance at short time scales

    Science.gov (United States)

    Fernandes, Brian; Hegde, Manu; Stanish, Paul C.; Mišković, Zoran L.; Radovanovic, Pavle V.

    2017-09-01

    We developed a comprehensive theoretical model describing the photoluminescence decay dynamics at short and long time scales based on the donor-acceptor defect interactions in γ-Ga2O3 nanocrystals, and quantitatively determined the importance of exclusion distance and spatial distribution of defects. We allowed for donors and acceptors to be adjacent to each other or separated by different exclusion distances. The optimal exclusion distance was found to be comparable to the donor Bohr radius and have a strong effect on the photoluminescence decay curve at short times. The importance of the exclusion distance at short time scales was confirmed by Monte Carlo simulations.

  17. Investigation of the motion of diesel injection jets using high-speed cinematography and short time holography

    International Nuclear Information System (INIS)

    Eisfeld, F.

    1987-01-01

    The knowledge about the penetration of diesel injection jets, particularly about the flow within the short behind the nozzle, and the arising of droplets from an injection jet is very limited. Experimental investigations are required to describe the process of penetration and spreading of the jet. The research method requires high speed cinematography and short time holography. Problems in the investigation method are described

  18. study on 113 Sn-113m In generator of the chromatographic column elution mode

    International Nuclear Information System (INIS)

    Abdel-Halim, A.A.

    2002-01-01

    this work has been carried out to study the optimum conditions required for local preparation of 113 Sn- 113m In radioisotope generator based on 12- molybdocerate- 113 Sn column matrix. this work was directed to: 1- investigate the optimum conditions of the tin target irradiation and dissolution processes. 2- study the different preparative conditions which affect the loading of 113 Sn radionuclide onto 12- molybdocerate (IV) columns and the elution of the generated 113m In radionuclide. 3- study the effect of generator life- time on the elution performance and quality control of the generated 113m In radionuclide over a period of 190 days

  19. Chirped or time modulated excitation compared to short pulses for photoacoustic imaging in acoustic attenuating media

    Science.gov (United States)

    Burgholzer, P.; Motz, C.; Lang, O.; Berer, T.; Huemer, M.

    2018-02-01

    In photoacoustic imaging, optically generated acoustic waves transport the information about embedded structures to the sample surface. Usually, short laser pulses are used for the acoustic excitation. Acoustic attenuation increases for higher frequencies, which reduces the bandwidth and limits the spatial resolution. One could think of more efficient waveforms than single short pulses, such as pseudo noise codes, chirped, or harmonic excitation, which could enable a higher information-transfer from the samples interior to its surface by acoustic waves. We used a linear state space model to discretize the wave equation, such as the Stoke's equation, but this method could be used for any other linear wave equation. Linear estimators and a non-linear function inversion were applied to the measured surface data, for onedimensional image reconstruction. The proposed estimation method allows optimizing the temporal modulation of the excitation laser such that the accuracy and spatial resolution of the reconstructed image is maximized. We have restricted ourselves to one-dimensional models, as for higher dimensions the one-dimensional reconstruction, which corresponds to the acoustic wave without attenuation, can be used as input for any ultrasound imaging method, such as back-projection or time-reversal method.

  20. Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times

    Directory of Open Access Journals (Sweden)

    Rao Nagesha AS

    2009-09-01

    Full Text Available Abstract Background Gene expression profiling of spontaneous tumors in the dog offers a unique translational opportunity to identify prognostic biomarkers and signaling pathways that are common to both canine and human. Osteosarcoma (OS accounts for approximately 80% of all malignant bone tumors in the dog. Canine OS are highly comparable with their human counterpart with respect to histology, high metastatic rate and poor long-term survival. This study investigates the prognostic gene profile among thirty-two primary canine OS using canine specific cDNA microarrays representing 20,313 genes to identify genes and cellular signaling pathways associated with survival. This, the first report of its kind in dogs with OS, also demonstrates the advantages of cross-species comparison with human OS. Results The 32 tumors were classified into two prognostic groups based on survival time (ST. They were defined as short survivors (dogs with poor prognosis: surviving fewer than 6 months and long survivors (dogs with better prognosis: surviving 6 months or longer. Fifty-one transcripts were found to be differentially expressed, with common upregulation of these genes in the short survivors. The overexpressed genes in short survivors are associated with possible roles in proliferation, drug resistance or metastasis. Several deregulated pathways identified in the present study, including Wnt signaling, Integrin signaling and Chemokine/cytokine signaling are comparable to the pathway analysis conducted on human OS gene profiles, emphasizing the value of the dog as an excellent model for humans. Conclusion A molecular-based method for discrimination of outcome for short and long survivors is useful for future prognostic stratification at initial diagnosis, where genes and pathways associated with cell cycle/proliferation, drug resistance and metastasis could be potential targets for diagnosis and therapy. The similarities between human and canine OS makes the

  1. Robust and Adaptive Online Time Series Prediction with Long Short-Term Memory

    Directory of Open Access Journals (Sweden)

    Haimin Yang

    2017-01-01

    Full Text Available Online time series prediction is the mainstream method in a wide range of fields, ranging from speech analysis and noise cancelation to stock market analysis. However, the data often contains many outliers with the increasing length of time series in real world. These outliers can mislead the learned model if treated as normal points in the process of prediction. To address this issue, in this paper, we propose a robust and adaptive online gradient learning method, RoAdam (Robust Adam, for long short-term memory (LSTM to predict time series with outliers. This method tunes the learning rate of the stochastic gradient algorithm adaptively in the process of prediction, which reduces the adverse effect of outliers. It tracks the relative prediction error of the loss function with a weighted average through modifying Adam, a popular stochastic gradient method algorithm for training deep neural networks. In our algorithm, the large value of the relative prediction error corresponds to a small learning rate, and vice versa. The experiments on both synthetic data and real time series show that our method achieves better performance compared to the existing methods based on LSTM.

  2. Robust and Adaptive Online Time Series Prediction with Long Short-Term Memory.

    Science.gov (United States)

    Yang, Haimin; Pan, Zhisong; Tao, Qing

    2017-01-01

    Online time series prediction is the mainstream method in a wide range of fields, ranging from speech analysis and noise cancelation to stock market analysis. However, the data often contains many outliers with the increasing length of time series in real world. These outliers can mislead the learned model if treated as normal points in the process of prediction. To address this issue, in this paper, we propose a robust and adaptive online gradient learning method, RoAdam (Robust Adam), for long short-term memory (LSTM) to predict time series with outliers. This method tunes the learning rate of the stochastic gradient algorithm adaptively in the process of prediction, which reduces the adverse effect of outliers. It tracks the relative prediction error of the loss function with a weighted average through modifying Adam, a popular stochastic gradient method algorithm for training deep neural networks. In our algorithm, the large value of the relative prediction error corresponds to a small learning rate, and vice versa. The experiments on both synthetic data and real time series show that our method achieves better performance compared to the existing methods based on LSTM.

  3. A combination of HARMONIE short time direct normal irradiance forecasts and machine learning: The #hashtdim procedure

    Science.gov (United States)

    Gastón, Martín; Fernández-Peruchena, Carlos; Körnich, Heiner; Landelius, Tomas

    2017-06-01

    The present work describes the first approach of a new procedure to forecast Direct Normal Irradiance (DNI): the #hashtdim that treats to combine ground information and Numerical Weather Predictions. The system is centered in generate predictions for the very short time. It combines the outputs from the Numerical Weather Prediction Model HARMONIE with an adaptive methodology based on Machine Learning. The DNI predictions are generated with 15-minute and hourly temporal resolutions and presents 3-hourly updates. Each update offers forecasts to the next 12 hours, the first nine hours are generated with 15-minute temporal resolution meanwhile the last three hours present hourly temporal resolution. The system is proved over a Spanish emplacement with BSRN operative station in south of Spain (PSA station). The #hashtdim has been implemented in the framework of the Direct Normal Irradiance Nowcasting methods for optimized operation of concentrating solar technologies (DNICast) project, under the European Union's Seventh Programme for research, technological development and demonstration framework.

  4. Short-range correlations in an extended time-dependent mean-field theory

    International Nuclear Information System (INIS)

    Madler, P.

    1982-01-01

    A generalization is performed of the time-dependent mean-field theory by an explicit inclusion of strong short-range correlations on a level of microscopic reversibility relating them to realistic nucleon-nucleon forces. Invoking a least action principle for correlated trial wave functions, equations of motion for the correlation functions and the single-particle model wave function are derived in lowest order of the FAHT cluster expansion. Higher order effects as well as long-range correlations are consider only to the extent to which they contribute to the mean field via a readjusted phenomenological effective two-body interaction. The corresponding correlated stationary problem is investigated and appropriate initial conditions to describe a heavy ion reaction are proposed. The singleparticle density matrix is evaluated

  5. The use of Matlab for colour fuzzy representation of multichannel EEG short time spectra.

    Science.gov (United States)

    Bigan, C; Strungaru, R

    1998-01-01

    During the last years, a lot of EEG research efforts was directed to intelligent methods for automatic analysis of data from multichannel EEG recordings. However, all the applications reported were focused on specific single tasks like detection of one specific "event" in the EEG signal: spikes, sleep spindles, epileptic seizures, K complexes, alpha or other rhythms or even artefacts. The aim of this paper is to present a complex system being able to perform a representation of the dynamic changes in frequency components of each EEG channel. This representation uses colours as a powerful means to show the only one frequency range chosen from the shortest epoch of signal able to be processed with the conventional "Short Time Fast Fourier Transform" (S.T.F.F.T.) method.

  6. Generic short-time propagation of sharp-boundaries wave packets

    Science.gov (United States)

    Granot, E.; Marchewka, A.

    2005-11-01

    A general solution to the "shutter" problem is presented. The propagation of an arbitrary initially bounded wave function is investigated, and the general solution for any such function is formulated. It is shown that the exact solution can be written as an expression that depends only on the values of the function (and its derivatives) at the boundaries. In particular, it is shown that at short times (t << 2mx2/hbar, where x is the distance to the boundaries) the wave function propagation depends only on the wave function's values (or its derivatives) at the boundaries of the region. Finally, we generalize these findings to a non-singular wave function (i.e., for wave packets with finite-width boundaries) and suggest an experimental verification.

  7. The Short-Time Behaviour of VIX Implied Volatilities in a Multifactor Stochastic Volatility Framework

    DEFF Research Database (Denmark)

    Barletta, Andrea; Nicolato, Elisa; Pagliarani, Stefano

    error bounds for VIX futures, options and implied volatilities. In particular, we derive exact asymptotic results for VIX implied volatilities, and their sensitivities, in the joint limit of short time-to-maturity and small log-moneyness. The obtained expansions are explicit, based on elementary...... approximations of equity (SPX) options. However, the generalizations needed to cover the case of VIX options are by no means straightforward as the dynamics of the underlying VIX futures are not explicitly known. To illustrate the accuracy of our technique, we provide numerical implementations for a selection...... functions and they neatly uncover how the VIX skew depends on the specific choice of the volatility and the vol-of-vol processes. Our results are based on perturbation techniques applied to the infinitesimal generator of the underlying process. This methodology has been previously adopted to derive...

  8. Short time administration of antirheumatic drugs - Methotrexate as a strong inhibitor of osteoblast's proliferation in vitro

    Directory of Open Access Journals (Sweden)

    Annussek Tobias

    2012-09-01

    Full Text Available Abstract Introduction Due to increasing use of disease modifying antirheumatic drugs (DMARDs as first line therapy in rheumatic diseases, dental and maxillofacial practitioner should be aware of drug related adverse events. Especially effects on bone-metabolism and its cells are discussed controversially. Therefore we investigate the in vitro effect of short time administration of low dose methotrexate (MTX on osteoblasts as essential part of bone remodelling cells. Methods Primary bovine osteoblasts (OBs were incubated with various concentrations of MTX, related to tissue concentrations, over a period of fourteen days by using a previously established standard protocol. The effect on cell proliferation as well as mitochondrial activity was assessed by using 3-(4, 5-dimethylthiazol-2-yl 2, 5-diphenyltetrazolium bromide (MTT assay, imaging and counting of living cells. Additionally, immunostaining of extracellular matrix proteins was used to survey osteogenic differentiation. Results All methods indicate a strong inhibition of osteoblast`s proliferation by short time administration of low dose MTX within therapeutically relevant concentrations of 1 to 1000nM, without affecting cell differentiation of middle-stage differentiated OBs in general. More over a significant decrease of cell numbers and mitochondrial activity was found at these MTX concentrations. The most sensitive method seems to be the MTT-assay. MTX-concentration of 0,01nM and concentrations below had no inhibitory effects anymore. Conclusion Even low dose methotrexate acts as a potent inhibitor of osteoblast’s proliferation and mitochondrial metabolism in vitro, without affecting main differentiation of pre-differentiated osteoblasts. These results suggest possible negative effects of DMARDs concerning bone healing and for example osseointegration of dental implants. Especially the specifics of the jaw bone with its high vascularisation and physiological high tissue metabolism

  9. Retention time generates short-term phytoplankton blooms in a shallow microtidal subtropical estuary

    Science.gov (United States)

    Odebrecht, Clarisse; Abreu, Paulo C.; Carstensen, Jacob

    2015-09-01

    In this study it was hypothesised that increasing water retention time promotes phytoplankton blooms in the shallow microtidal Patos Lagoon estuary (PLE). This hypothesis was tested using salinity variation as a proxy of water retention time and chlorophyll a for phytoplankton biomass. Submersible sensors fixed at 5 m depth near the mouth of PLE continuously measured water temperature, salinity and pigments fluorescence (calibrated to chlorophyll a) between March 2010 and 12th of December 2011, with some gaps. Salinity variations were used to separate alternating patterns of outflow of lagoon water (salinity 24; 35% of the time). The two transition phases represented a rapid change from lagoon water outflow to marine water inflow and a more gradually declining salinity between the dominating inflow and outflow conditions. During the latter of these, a significant chlorophyll a increase relative to that expected from a linear mixing relationship was observed at intermediate salinities (10-20). The increase in chlorophyll a was positively related to the duration of the prior coastal water inflow in the PLE. Moreover, chlorophyll a increase was significantly higher during austral spring-summer than autumn-winter, probably due to higher light and nutrient availability in the former. Moreover, the retention time process operating on time scales of days influences the long-term phytoplankton variability in this ecosystem. Comparing these results with monthly data from a nearby long-term water quality monitoring station (1993-2011) support the hypothesis that chlorophyll a accumulations occur after marine inflow events, whereas phytoplankton does not accumulate during high water outflow, when the water residence time is short. These results suggest that changing hydrological pattern is the most important mechanism underlying phytoplankton blooms in the PLE.

  10. Motor Fault Diagnosis Based on Short-time Fourier Transform and Convolutional Neural Network

    Science.gov (United States)

    Wang, Li-Hua; Zhao, Xiao-Ping; Wu, Jia-Xin; Xie, Yang-Yang; Zhang, Yong-Hong

    2017-11-01

    With the rapid development of mechanical equipment, the mechanical health monitoring field has entered the era of big data. However, the method of manual feature extraction has the disadvantages of low efficiency and poor accuracy, when handling big data. In this study, the research object was the asynchronous motor in the drivetrain diagnostics simulator system. The vibration signals of different fault motors were collected. The raw signal was pretreated using short time Fourier transform (STFT) to obtain the corresponding time-frequency map. Then, the feature of the time-frequency map was adaptively extracted by using a convolutional neural network (CNN). The effects of the pretreatment method, and the hyper parameters of network diagnostic accuracy, were investigated experimentally. The experimental results showed that the influence of the preprocessing method is small, and that the batch-size is the main factor affecting accuracy and training efficiency. By investigating feature visualization, it was shown that, in the case of big data, the extracted CNN features can represent complex mapping relationships between signal and health status, and can also overcome the prior knowledge and engineering experience requirement for feature extraction, which is used by traditional diagnosis methods. This paper proposes a new method, based on STFT and CNN, which can complete motor fault diagnosis tasks more intelligently and accurately.

  11. Multi-time-scale heat transfer modeling of turbid tissues exposed to short-pulsed irradiations.

    Science.gov (United States)

    Kim, Kyunghan; Guo, Zhixiong

    2007-05-01

    A combined hyperbolic radiation and conduction heat transfer model is developed to simulate multi-time-scale heat transfer in turbid tissues exposed to short-pulsed irradiations. An initial temperature response of a tissue to an ultrashort pulse irradiation is analyzed by the volume-average method in combination with the transient discrete ordinates method for modeling the ultrafast radiation heat transfer. This response is found to reach pseudo steady state within 1 ns for the considered tissues. The single pulse result is then utilized to obtain the temperature response to pulse train irradiation at the microsecond/millisecond time scales. After that, the temperature field is predicted by the hyperbolic heat conduction model which is solved by the MacCormack's scheme with error terms correction. Finally, the hyperbolic conduction is compared with the traditional parabolic heat diffusion model. It is found that the maximum local temperatures are larger in the hyperbolic prediction than the parabolic prediction. In the modeled dermis tissue, a 7% non-dimensional temperature increase is found. After about 10 thermal relaxation times, thermal waves fade away and the predictions between the hyperbolic and parabolic models are consistent.

  12. Short locking time and low jitter phase-locked loop based on slope charge pump control

    International Nuclear Information System (INIS)

    Guo Zhongjie; Liu Youbao; Wu Longsheng; Wang Xihu; Tang Wei

    2010-01-01

    A novel structure of a phase-locked loop (PLL) characterized by a short locking time and low jitter is presented, which is realized by generating a linear slope charge pump current dependent on monitoring the output of the phase frequency detector (PFD) to implement adaptive bandwidth control. This improved PLL is created by utilizing a fast start-up circuit and a slope current control on a conventional charge pump PLL. First, the fast start-up circuit is enabled to achieve fast pre-charging to the loop filter. Then, when the output pulse of the PFD is larger than a minimum value, the charge pump current is increased linearly by the slope current control to ensure a shorter locking time and a lower jitter. Additionally, temperature variation is attenuated with the temperature compensation in the charge pump current design. The proposed PLL has been fabricated in a kind of DSP chip based on a 0.35 μm CMOS process. Comparing the characteristics with the classical PLL, the proposed PLL shows that it can reduce the locking time by 60% with a low peak-to-peak jitter of 0.3% at a wide operation temperature range. (semiconductor integrated circuits)

  13. SHORT DISSIPATION TIMES OF PROTO-PLANETARY DISKS: AN ARTIFACT OF SELECTION EFFECTS?

    International Nuclear Information System (INIS)

    Pfalzner, Susanne; Steinhausen, Manuel; Menten, Karl

    2014-01-01

    The frequency of disks around young stars, a key parameter for understanding planet formation, is most readily determined in young stellar clusters where many relatively coeval stars are located in close proximity. Observational studies seem to show that the disk frequency decreases rapidly with cluster age with <10% of cluster stars retaining their disks for longer than 2-6 Myr. Given that at least half of all stars in the field seem to harbor one or more planets, this would imply extremely fast disk dispersal and rapid planet growth. Here we question the validity of this constraint by demonstrating that the short disk dissipation times inferred to date might have been heavily underestimated by selection effects. Critically, for ages >3 Myr only stars that originally populated the densest areas of very populous clusters, which are prone to disk erosion, are actually considered. This tiny sample may not be representative of the majority of stars. In fact, the higher disk fractions in co-moving groups indicate that it is likely that over 30% of all field stars retain their disks well beyond 10 Myr, leaving ample time for planet growth. Equally, our solar system, with a likely formation time >10 Myr, need no longer be an exception but in fact typical of planetary systems

  14. Impaired health status in Type D patients following PCI in the drug-eluting stent era

    DEFF Research Database (Denmark)

    Pedersen, Susanne S.; Denollet, Johan; Ong, Andrew T L

    2007-01-01

    Drug-eluting stenting reduces restenosis post-percutaneous coronary intervention (PCI), but subgroups of patients may not benefit optimally from this procedure. We examined the impact of Type D personality on health status over time and the clinical relevance of Type D as a predictor of impaired...... health status at 12 months in unselected post-PCI patients....

  15. Development of High Temperature Short Time Vertebrate-Blood Pasteurization Equipment for Tsetse Fly Diets

    Energy Technology Data Exchange (ETDEWEB)

    Moravek, I; Lach, J [Department of Manufacturing Systems, Slovak Technical University Namestie Slobody 17 812 31 Bratislava (Slovakia); Takac, P [Institute of Zoology, SAV, Bratislava (Slovakia)

    2012-07-15

    Tsetse flies feed only on vertebrate blood, but the collection and processing of blood is expensive, it must be stored at -20{sup o}C requiring costly storage rooms and reliable electricity, and it must be irradiated to reduce bacterial contamination. This is tolerable for small colonies, but as colony size increases to service large- scale programmes, the supply and processing of blood becomes critical. Blood is normally collected from cattle at slaughter. This process is necessarily not aseptic, and large-scale collection is only possible where the animals are suspended for bleeding. One alternative to blood decontamination is using the High Temperature Short time Pasteurization (HTST) method. The food processing industry uses pasteurization to reduce bacterial load in a wide range of products. Our previous results indicated that for the control of the blood pasteurization process, to reach satisfactory bacteriological purity and at the same time to prevent the blood from coagulating, it is important to study temperature and time and also some other parameters that could predict blood coagulation. Crucial for blood coagulation is to study blood viscosity. Classical heat exchangers are not suitable for blood pasteurization. In such equipment the blood coagulation depends on temperature and time. Besides the relatively low temperatures, blood is coagulating with cumulative time until total shutdown of blood flow. After a series of experiments we found a solution using microwave systems. To verify the microwave heating concept, we built an experimental workstation. First we verified the accuracy of the applicator design from the aspect of output adaptation to the power source. Also we installed measuring equipment. This system complies with the requirements of quick heating with sufficiently high heat accumulation. By utilizing standard components for the base of the microwave generator, it is possible to markedly reduce the final price of the equipment. (author)

  16. Multiple dual mode counter-current chromatography with variable duration of alternating phase elution steps.

    Science.gov (United States)

    Kostanyan, Artak E; Erastov, Andrey A; Shishilov, Oleg N

    2014-06-20

    The multiple dual mode (MDM) counter-current chromatography separation processes consist of a succession of two isocratic counter-current steps and are characterized by the shuttle (forward and back) transport of the sample in chromatographic columns. In this paper, the improved MDM method based on variable duration of alternating phase elution steps has been developed and validated. The MDM separation processes with variable duration of phase elution steps are analyzed. Basing on the cell model, analytical solutions are developed for impulse and non-impulse sample loading at the beginning of the column. Using the analytical solutions, a calculation program is presented to facilitate the simulation of MDM with variable duration of phase elution steps, which can be used to select optimal process conditions for the separation of a given feed mixture. Two options of the MDM separation are analyzed: 1 - with one-step solute elution: the separation is conducted so, that the sample is transferred forward and back with upper and lower phases inside the column until the desired separation of the components is reached, and then each individual component elutes entirely within one step; 2 - with multi-step solute elution, when the fractions of individual components are collected in over several steps. It is demonstrated that proper selection of the duration of individual cycles (phase flow times) can greatly increase the separation efficiency of CCC columns. Experiments were carried out using model mixtures of compounds from the GUESSmix with solvent systems hexane/ethyl acetate/methanol/water. The experimental results are compared to the predictions of the theory. A good agreement between theory and experiment has been demonstrated. Copyright © 2014 Elsevier B.V. All rights reserved.

  17. Drug elution from high-dose antibiotic-loaded acrylic cement: a comparative, in vitro study.

    Science.gov (United States)

    Gasparini, Giorgio; De Gori, Marco; Calonego, Giovanni; Della Bora, Tommaso; Caroleo, Benedetto; Galasso, Olimpio

    2014-11-01

    High-dose antibiotic-loaded acrylic cement (ALAC) is used for managing peri-prosthetic joint infections (PJIs). The marked increase in resistant high-virulence bacteria is drawing the attention of physicians toward alternative antimicrobial formulations loaded into acrylic bone cement. The aim of this in vitro study was to determine the elution kinetics of 14 different high-dose ALACs. All ALAC samples showed a burst release of antibiotics in the first hour, progressively decreasing over time, and elution curves strictly adhered to a nonlinear regression analysis formula. Among aminoglycosides, commonly seen as the most appropriate antibiotics to be loaded into the bone cement, the highest elution rate was that of tobramycin. Among the glycopeptides, a class of antibiotics that should be considered to treat PJIs because of the prevalence of aminoglycoside resistance, vancomycin showed better elution than teicoplanin. Clindamycin, which can be associated with aminoglycosides to prepare ALACs and represents a useful option against the most common pathogens responsible for PJIs, showed the highest absolute and relative elutions among all the tested formulations. A noticeable elution was also detected for colistin, an antibiotic of last resort for treating multidrug-resistant bacteria. The current study demonstrates theoretical advantages in the preparation of ALAC for some antibiotics not routinely used in the clinical setting for PJIs. The use of these antibiotics based on the infecting bacteria sensitivity may represent a useful option for physicians to eradicate PJIs. In vivo testing should be considered in the future to confirm the results of this study. Copyright 2014, SLACK Incorporated.

  18. Time domain numerical calculations of the short electron bunch wakefields in resistive structures

    Energy Technology Data Exchange (ETDEWEB)

    Tsakanian, Andranik

    2010-10-15

    The acceleration of electron bunches with very small longitudinal and transverse phase space volume is one of the most actual challenges for the future International Linear Collider and high brightness X-Ray Free Electron Lasers. The exact knowledge on the wake fields generated by the ultra-short electron bunches during its interaction with surrounding structures is a very important issue to prevent the beam quality degradation and to optimize the facility performance. The high accuracy time domain numerical calculations play the decisive role in correct evaluation of the wake fields in advanced accelerators. The thesis is devoted to the development of a new longitudinally dispersion-free 3D hybrid numerical scheme in time domain for wake field calculation of ultra short bunches in structures with walls of finite conductivity. The basic approaches used in the thesis to solve the problem are the following. For materials with high but finite conductivity the model of the plane wave reflection from a conducting half-space is used. It is shown that in the conductive half-space the field components perpendicular to the interface can be neglected. The electric tangential component on the surface contributes to the tangential magnetic field in the lossless area just before the boundary layer. For high conducting media, the task is reduced to 1D electromagnetic problem in metal and the so-called 1D conducting line model can be applied instead of a full 3D space description. Further, a TE/TM (''transverse electric - transverse magnetic'') splitting implicit numerical scheme along with 1D conducting line model is applied to develop a new longitudinally dispersion-free hybrid numerical scheme in the time domain. The stability of the new hybrid numerical scheme in vacuum, conductor and bound cell is studied. The convergence of the new scheme is analyzed by comparison with the well-known analytical solutions. The wakefield calculations for a number of

  19. Short time series analysis of Didymosphenia geminata blooming in the Oreti River, New Zealand

    Science.gov (United States)

    Garcia, T.; Kilroy, C.; Larned, S.; Packman, A. I.; Kumar, P.

    2010-12-01

    The mat-forming diatom Didymosphenia geminata was introduced to New Zealand in 2004, and subsequently spread to many rivers on the south island. D geminata mats are exceptionally dense and thick. Extensive blooms of this introduced organism have substantially modified the benthic environment in many New Zealand rivers, but the factors that contribute to D. geminata blooming are not well understood. We synthesized a sequence of observations of D. geminata areal coverage and thickness to examine physical and chemical controls on the growth and persistence of D germinata. We analyzed the best available time series on the distribution of this organism in New Zealand, observations in the Oreti River every 15 days spanning April 2006 to May 2007. During this period, mean D. geminata coverage of the river bed was ~52% and the mean mat thickness was ~6 mm. Relationships between time-series observations of D. geminata and 13 different physical and chemical variables were analyzed using linear and nonlinear methods. Areal cover and thickness of D geminata mats were found to be influenced by both slow and fast dynamic processes. The spread of the organism, in terms of % cover, was highly correlated with conductivity, ammonium, nitrate, dissolved oxygen, and total nitrogen with short time lags (fast dynamics). Moreover, water clarity, cloud cover, and flow were highly correlated with % cover with long time lags, indicating that these conditions exert long-term control on D. geminata growth. Areal coverage and thickness were found to be highly correlated, but the variables associated with slow and fast dynamics of these two measures were not identical. The variables found to be highly correlated with D. germinata thickness and represented fast dynamics were temperature, dissolved oxygen, conductivity, nitrate, and total nitrogen. Additionally, the variables influencing the slow dynamics of D. germinata thickness were flow, water clarity, turbidity and total phosphorous.

  20. Short Term Prediction of PM10 Concentrations Using Seasonal Time Series Analysis

    Directory of Open Access Journals (Sweden)

    Hamid Hazrul Abdul

    2016-01-01

    Full Text Available Air pollution modelling is one of an important tool that usually used to make short term and long term prediction. Since air pollution gives a big impact especially to human health, prediction of air pollutants concentration is needed to help the local authorities to give an early warning to people who are in risk of acute and chronic health effects from air pollution. Finding the best time series model would allow prediction to be made accurately. This research was carried out to find the best time series model to predict the PM10 concentrations in Nilai, Negeri Sembilan, Malaysia. By considering two seasons which is wet season (north east monsoon and dry season (south west monsoon, seasonal autoregressive integrated moving average model were used to find the most suitable model to predict the PM10 concentrations in Nilai, Negeri Sembilan by using three error measures. Based on AIC statistics, results show that ARIMA (1, 1, 1 × (1, 0, 012 is the most suitable model to predict PM10 concentrations in Nilai, Negeri Sembilan.

  1. Short-time regularity assessment of fibrillatory waves from the surface ECG in atrial fibrillation

    International Nuclear Information System (INIS)

    Alcaraz, Raúl; Martínez, Arturo; Hornero, Fernando; Rieta, José J

    2012-01-01

    This paper proposes the first non-invasive method for direct and short-time regularity quantification of atrial fibrillatory (f) waves from the surface ECG in atrial fibrillation (AF). Regularity is estimated by computing individual morphological variations among f waves, which are delineated and extracted from the atrial activity (AA) signal, making use of an adaptive signed correlation index. The algorithm was tested on real AF surface recordings in order to discriminate atrial signals with different organization degrees, providing a notably higher global accuracy (90.3%) than the two non-invasive AF organization estimates defined to date: the dominant atrial frequency (70.5%) and sample entropy (76.1%). Furthermore, due to its ability to assess AA regularity wave to wave, the proposed method is also able to pursue AF organization time course more precisely than the aforementioned indices. As a consequence, this work opens a new perspective in the non-invasive analysis of AF, such as the individualized study of each f wave, that could improve the understanding of AF mechanisms and become useful for its clinical treatment. (paper)

  2. Polynomial Phase Estimation Based on Adaptive Short-Time Fourier Transform.

    Science.gov (United States)

    Jing, Fulong; Zhang, Chunjie; Si, Weijian; Wang, Yu; Jiao, Shuhong

    2018-02-13

    Polynomial phase signals (PPSs) have numerous applications in many fields including radar, sonar, geophysics, and radio communication systems. Therefore, estimation of PPS coefficients is very important. In this paper, a novel approach for PPS parameters estimation based on adaptive short-time Fourier transform (ASTFT), called the PPS-ASTFT estimator, is proposed. Using the PPS-ASTFT estimator, both one-dimensional and multi-dimensional searches and error propagation problems, which widely exist in PPSs field, are avoided. In the proposed algorithm, the instantaneous frequency (IF) is estimated by S-transform (ST), which can preserve information on signal phase and provide a variable resolution similar to the wavelet transform (WT). The width of the ASTFT analysis window is equal to the local stationary length, which is measured by the instantaneous frequency gradient (IFG). The IFG is calculated by the principal component analysis (PCA), which is robust to the noise. Moreover, to improve estimation accuracy, a refinement strategy is presented to estimate signal parameters. Since the PPS-ASTFT avoids parameter search, the proposed algorithm can be computed in a reasonable amount of time. The estimation performance, computational cost, and implementation of the PPS-ASTFT are also analyzed. The conducted numerical simulations support our theoretical results and demonstrate an excellent statistical performance of the proposed algorithm.

  3. Multifractals embedded in short time series: An unbiased estimation of probability moment

    Science.gov (United States)

    Qiu, Lu; Yang, Tianguang; Yin, Yanhua; Gu, Changgui; Yang, Huijie

    2016-12-01

    An exact estimation of probability moments is the base for several essential concepts, such as the multifractals, the Tsallis entropy, and the transfer entropy. By means of approximation theory we propose a new method called factorial-moment-based estimation of probability moments. Theoretical prediction and computational results show that it can provide us an unbiased estimation of the probability moments of continuous order. Calculations on probability redistribution model verify that it can extract exactly multifractal behaviors from several hundred recordings. Its powerfulness in monitoring evolution of scaling behaviors is exemplified by two empirical cases, i.e., the gait time series for fast, normal, and slow trials of a healthy volunteer, and the closing price series for Shanghai stock market. By using short time series with several hundred lengths, a comparison with the well-established tools displays significant advantages of its performance over the other methods. The factorial-moment-based estimation can evaluate correctly the scaling behaviors in a scale range about three generations wider than the multifractal detrended fluctuation analysis and the basic estimation. The estimation of partition function given by the wavelet transform modulus maxima has unacceptable fluctuations. Besides the scaling invariance focused in the present paper, the proposed factorial moment of continuous order can find its various uses, such as finding nonextensive behaviors of a complex system and reconstructing the causality relationship network between elements of a complex system.

  4. Two Machine Learning Approaches for Short-Term Wind Speed Time-Series Prediction.

    Science.gov (United States)

    Ak, Ronay; Fink, Olga; Zio, Enrico

    2016-08-01

    The increasing liberalization of European electricity markets, the growing proportion of intermittent renewable energy being fed into the energy grids, and also new challenges in the patterns of energy consumption (such as electric mobility) require flexible and intelligent power grids capable of providing efficient, reliable, economical, and sustainable energy production and distribution. From the supplier side, particularly, the integration of renewable energy sources (e.g., wind and solar) into the grid imposes an engineering and economic challenge because of the limited ability to control and dispatch these energy sources due to their intermittent characteristics. Time-series prediction of wind speed for wind power production is a particularly important and challenging task, wherein prediction intervals (PIs) are preferable results of the prediction, rather than point estimates, because they provide information on the confidence in the prediction. In this paper, two different machine learning approaches to assess PIs of time-series predictions are considered and compared: 1) multilayer perceptron neural networks trained with a multiobjective genetic algorithm and 2) extreme learning machines combined with the nearest neighbors approach. The proposed approaches are applied for short-term wind speed prediction from a real data set of hourly wind speed measurements for the region of Regina in Saskatchewan, Canada. Both approaches demonstrate good prediction precision and provide complementary advantages with respect to different evaluation criteria.

  5. Long Short-Term Memory Neural Networks for Online Disturbance Detection in Satellite Image Time Series

    Directory of Open Access Journals (Sweden)

    Yun-Long Kong

    2018-03-01

    Full Text Available A satellite image time series (SITS contains a significant amount of temporal information. By analysing this type of data, the pattern of the changes in the object of concern can be explored. The natural change in the Earth’s surface is relatively slow and exhibits a pronounced pattern. Some natural events (for example, fires, floods, plant diseases, and insect pests and human activities (for example, deforestation and urbanisation will disturb this pattern and cause a relatively profound change on the Earth’s surface. These events are usually referred to as disturbances. However, disturbances in ecosystems are not easy to detect from SITS data, because SITS contain combined information on disturbances, phenological variations and noise in remote sensing data. In this paper, a novel framework is proposed for online disturbance detection from SITS. The framework is based on long short-term memory (LSTM networks. First, LSTM networks are trained by historical SITS. The trained LSTM networks are then used to predict new time series data. Last, the predicted data are compared with real data, and the noticeable deviations reveal disturbances. Experimental results using 16-day compositions of the moderate resolution imaging spectroradiometer (MOD13Q1 illustrate the effectiveness and stability of the proposed approach for online disturbance detection.

  6. Rotor-System Log-Decrement Identification Using Short-Time Fourier-Transform Filter

    Directory of Open Access Journals (Sweden)

    Qihang Li

    2015-01-01

    Full Text Available With the increase of the centrifugal compressor capability, such as large scale LNG and CO2 reinjection, the stability margin evaluation is crucial to assure the compressor work in the designed operating conditions in field. Improving the precision of parameter identification of stability is essential and necessary as well. Based on the time-varying characteristics of response vibration during the sine-swept process, a short-time Fourier transform (STFT filter was introduced to increase the signal-noise ratio and improve the accuracy of the estimated stability parameters. A finite element model was established to simulate the sine-swept process, and the simulated vibration signals were used to study the filtering effect and demonstrate the feasibility to identify the stability parameters by using Multiple-Input and Multiple-Output system identification method that combines the prediction error method and instrumental variable method. Simulation results show that the identification method with STFT filter improves the estimated accuracy much well and makes the curves of frequency response function clearer. Experiment was carried out on a test rig as well, which indicates the identification method is feasible in stability identification, and the results of experiment indicate that STFT filter works very well.

  7. Timing of introduction of complementary food: short- and long-term health consequences.

    Science.gov (United States)

    Przyrembel, Hildegard

    2012-01-01

    Complementary food is needed when breast milk (or infant formula) alone is no longer sufficient for both nutritional and developmental reasons. The timing of its introduction, therefore, is an individual decision, although 6 months of exclusive breastfeeding can be recommended for most healthy term infants. The new foods are intended to 'complement' ongoing breastfeeding with those dietary items whose intake has become marginal or insufficient. Both breastfeeding and complementary feeding can have direct or later consequences on health. The evaluation of consequences of both early and late introduction of complementary food can neither disregard the effect of breastfeeding compared to formula feeding nor the composition or quality of the complementary food. Possible short-term health effects concern growth velocity and infections, and possible long-term effects may relate to atopic diseases, type 1 and 2 diabetes, obesity and neuromuscular development. On the basis of the currently available evidence, it is impossible to exactly determine the age when risks related to the start of complementary feeding are lowest or highest for most of these effects, with the possible exception of infections and early growth velocity. The present knowledge on undesirable health effects, however, is mainly based on observational studies, and although some mechanisms have been proposed, further prospective studies have to clarify these unsolved issues. Even less evidence on the consequences of the timing of complementary food introduction is available for formula-fed infants. Copyright © 2012 S. Karger AG, Basel.

  8. Influence of Short-time Oxidation on Corrosion Properties of Directionally Solidified Superalloys with Different Orientations

    Directory of Open Access Journals (Sweden)

    MA Luo-ning

    2016-07-01

    Full Text Available In order to investigate the corrosion performance on intersecting and longitudinal surfaces of unoxidized and oxidized directionally solidified superalloys, Ni-base directionally solidified superalloy DZ125 and Co-base directionally solidified superalloy DZ40M were selected. Oxidation behavior on both alloys with different orientations was investigated at 1050℃ at different times, simulating the oxidation process of vanes or blades in service; subsequent electrochemical performance in 3.5%NaCl aqueous solution was studied on two orientations of unoxidized and oxidized alloys, simulating the corrosion process of superalloy during downtime. The results show that grain boundaries and sub-boundaries of directionally solidified superalloys are susceptible to corrosion and thus longitudinal surface with lower area fraction of grain boundaries has higher corrosion resistance. Compared to intersecting surface of alloys, the structure of grain boundaries of longitudinal surface is less conducive to diffusion and thus the oxidation rate on longitudinal surface is lower. Formation of oxide layers on alloys after short-time oxidation provides protective effect and enhances the corrosion resistance.

  9. Incorporating geostrophic wind information for improved space–time short-term wind speed forecasting

    KAUST Repository

    Zhu, Xinxin

    2014-09-01

    Accurate short-term wind speed forecasting is needed for the rapid development and efficient operation of wind energy resources. This is, however, a very challenging problem. Although on the large scale, the wind speed is related to atmospheric pressure, temperature, and other meteorological variables, no improvement in forecasting accuracy was found by incorporating air pressure and temperature directly into an advanced space-time statistical forecasting model, the trigonometric direction diurnal (TDD) model. This paper proposes to incorporate the geostrophic wind as a new predictor in the TDD model. The geostrophic wind captures the physical relationship between wind and pressure through the observed approximate balance between the pressure gradient force and the Coriolis acceleration due to the Earth’s rotation. Based on our numerical experiments with data from West Texas, our new method produces more accurate forecasts than does the TDD model using air pressure and temperature for 1to 6-hour-ahead forecasts based on three different evaluation criteria. Furthermore, forecasting errors can be further reduced by using moving average hourly wind speeds to fit the diurnal pattern. For example, our new method obtains between 13.9% and 22.4% overall mean absolute error reduction relative to persistence in 2-hour-ahead forecasts, and between 5.3% and 8.2% reduction relative to the best previous space-time methods in this setting.

  10. Comparison of elution efficiency of 99Mo/99mTc generator using theoretical and a free web based software method

    International Nuclear Information System (INIS)

    Kiran Kumar, J.K.; Sharma, S.; Chakraborty, D.; Singh, B.; Bhattacharaya, A.; Mittal, B.R.; Gayana, S.

    2010-01-01

    Full text: Generator is constructed on the principle of decay growth relationship between a long lived parent radionuclide and short lived daughter radionuclide. Difference in chemical properties of daughter and parent radionuclide helps in efficient separation of the two radionuclides. Aim and Objectives: The present study was designed to calculate the elution efficiency of the generator using the traditional formula based method and free web based software method. Materials and Methods: 99 Mo/ 99m Tc MON.TEK (Monrol, Gebze) generator and sterile 0.9% NaCl vial and vacuum vial in the lead shield were used for the elution. A new 99 Mo/ 99m Tc generator (calibrated activity 30GBq) calibrated for thursday was received on monday morning in our department. Generator was placed behind lead bricks in fume hood. The rubber plugs of both vacuum and 0.9% NaCl vial were wiped with 70% isopropyl alcohol swabs. Vacuum vial placed inside the lead shield was inserted in the vacuum position simultaneously 10 ml NaCl vial was inserted in the second slot. After 1-2 min vacuum vial was removed without moving the emptied 0.9%NaCl vial. The vacuum slot was covered with another sterile vial to maintain sterility. The RAC was measured in the calibrated dose calibrator (Capintec, 15 CRC). The elution efficiency was calculated theoretically and using free web based software (Apache Web server (www.apache.org) and PHP (www.php.net). Web site of the Italian Association of Nuclear Medicine and Molecular Imaging (www.aimn.it). Results: The mean elution efficiency calculated by theoretical method was 93.95% +0.61. The mean elution efficiency as calculated by the software was 92.85% + 0.89. There was no statistical difference in both the methods. Conclusion: The free web based software provides precise and reproducible results and thus saves time and mathematical calculation steps. This enables a rational use of available activity and also enabling a selection of the type and number of

  11. Hypotonic elution, a new desorption principle in immunoadsorbent chromatography

    DEFF Research Database (Denmark)

    Danielsen, Erik Michael; Sjöström, H; Norén, O

    1982-01-01

    of finding an efficient means of elution which is not denaturing to neither the purified enzyme nor the immunoadsorbent column. Common properties of the microvillar enzymes with regard to amphiphilicity, glycosylation or subunit composition could hypothetically account for the similar elution properties...

  12. Disappearing and reappearing differences in drug-eluting stent use by race.

    Science.gov (United States)

    Federspiel, Jerome J; Stearns, Sally C; Reiter, Kristin L; Geissler, Kimberley H; Triplette, Matthew A; D'Arcy, Laura P; Sheridan, Brett C; Rossi, Joseph S

    2013-04-01

    Drug-eluting coronary stents (DES) rapidly dominated the marketplace in the United States after approval in 2003, but utilization rates were initially lower among African American patients. We assess whether racial differences persisted as DES diffused into practice. Medicare claims data were used to identify coronary stenting procedures among elderly patients with acute coronary syndromes (ACS). Regression models of the choice of DES versus bare mental stent controlled for demographics, ACS type, co-morbidities and hospital characteristics. Diffusion was assessed in the short run (2003-2004) and long run (2007), with the effect of race calculated to allow for time-varying effects. The sample included 381,887 Medicare beneficiaries treated with stent insertion; approximately 5% were African American. Initially (May 2003-February 2004), African American race was associated with lower DES use compared to other races (44.3% versus 46.5%, P differences were not significant (79.8% versus 80.3%, P = 0.45). Subsequent concerns regarding DES safety caused reductions in DES use, with African Americans having lower use than other racial groups in 2007 (63.1% versus 65.2%, P differences in race reflect decisions regarding treatment appropriateness. © 2011 Blackwell Publishing Ltd.

  13. Severe symptoms of short tear break-up time dry eye are associated with accommodative microfluctuations

    Directory of Open Access Journals (Sweden)

    Kaido M

    2017-05-01

    Full Text Available Minako Kaido,1,2 Motoko Kawashima,1 Reiko Ishida,1,3 Kazuo Tsubota1 1Department of Ophthalmology, Keio University School of Medicine, Tokyo, 2Wada Eye Clinic, Chiba, 3Ishida Eye Clinic, Shizuoka, Japan Aim: Validating the hypothesis that accommodative microfluctuations (AMFs may be associated with severe symptoms in short tear break-up time (BUT dry eye (DE. Methods: This study included 12 subjects with short BUT DE (age: 49.6±18.3 years. Diagnoses were performed based on the presence of DE symptoms, BUT ≤5 s, Schirmer score >5 mm, and negative keratoconjunctival epithelial damage. Tear evaluation, AMF, and functional visual acuity (VA examinations were conducted before and after DE treatment. The AMF parameters evaluated were: total high-frequency component (HFC, HFC with low accommodation for the task of staring into the distance (HFC1, HFC with high accommodation for deskwork (HFC2. A subjective questionnaire of DE symptoms was also performed. Results: Mean BUT increased from 1.9±2.0 to 6.4±2.5 s after treatment (P<0.05. The mean logarithm of the minimum angle of resolution functional VA significantly improved (from 0.19±0.19 to 0.12±0.17; P<0.05. Mean power spectrum values for total HFC and HFC1 decreased (from 61.3±5.7 to 53.8±6.6 dB and from 62.9±10.5 to 52.4±6.2 dB, respectively; P<0.05, while the mean HFC2 power spectrum values did not differ before and after treatment (P>0.05. Subjective DE symptoms were reduced in nine patients. Conclusion: Along with the improvement of BUT after treatment, DE symptoms diminished and HFC1 and functional VA improved, suggesting that tear film instability is associated with deterioration of functional VA, AMF, and DE symptoms. Keywords: accommodative microfluctuation, ciliary muscle spasm, dry eye, ocular fatigue, tear break-up time, functional visual acuity 

  14. Time Course Changes in Selected Biochemical Stress Indices in Broilers Exposed to Short-term Noise

    Directory of Open Access Journals (Sweden)

    Iveta Bedáňová

    2010-01-01

    Full Text Available Time course changes in selected biochemical stress indices (corticosterone, triglycerides, glucose, cholesterol following short-term noise exposure at 100 dB for 28 min were studied in broilers aged 42 days. Corticosterone concentrations were found to increase during the first 10 min of noise exposure and to differ significantly from the control (background sound – 50 dB at Time 10 min and 14 min, then decreased continually and at 28 min returned to the initial prestress value. Triglyceride concentrations increased in broilers exposed to 100 dB noise during the first 12 min with a significant difference from the control at 12 min and 14 min. Glucose concentrations were higher due to 100 dB noise exposure for almost the entire period monitored, with significant differences between 100 dB and control broilers at 6 min and from 10 min to 14 min. Similarly as for the corticosterone concentration, a drop in triglycerides and glucose concentrations was seen approximately from Time 14 min and a return to the pre-stress value at 28 min. The cholesterol concentrations showed various temporal patterns with no significant difference between 100 dB and control broilers in this experiment. The pattern of response found in the study indicates that 100 dB noise represents a stress factor in broilers, however, there is the ability of broilers to adapt to an increased level of noise at this intensity after the first 14 min of exposure. The findings obtained in the study may contribute to expanding detailed knowledge of physiological stress responses to this specific noise stimulus in poultry, and could thereby be used to improve the welfare of broilers in intensive housing systems.

  15. Biolimus-eluting biodegradable polymer-coated stent versus durable polymer-coated sirolimus-eluting stent in unselected patients receiving percutaneous coronary intervention (SORT OUT V)

    DEFF Research Database (Denmark)

    Christiansen, Evald Høj; Jensen, Lisette Okkels; Thayssen, Per

    2013-01-01

    Third-generation biodegradable polymer drug-eluting stents might reduce the risk of stent thrombosis compared with first-generation permanent polymer drug-eluting stents. We aimed to further investigate the effects of a biodegradable polymer biolimus-eluting stent compared with a durable polymer......-coated sirolimus-eluting stent in a population-based setting....

  16. Short communication. Harvest time in hedgerow Arbequina olive orchards in areas with early frosts

    Energy Technology Data Exchange (ETDEWEB)

    Gracia, P.; Sanchez-Gimeno, A. C.; Benito, M.; Oria, R.; Lasa, J. M.

    2012-11-01

    The shortening of harvest time attained in hedgerow olive (Olea europaea L.) orchards represents an advantage for the adoption of this cropping system in areas that are prone to suffer frost during the harvest period. To establish an optimal harvesting window, we carried out a study of the fruit ripening process on a hedgerow orchard of Arbequina olive trees, located in Zaragoza (Spain). From 2007 to 2009, oil accumulation on the fruit (% of dry weight) and oil yield (grams of oil per 100 fruits) were monitored, from early September to late November. Over the three years both variables peaked around November 15th, indicating that Arbequina reached full ripening earlier than has been reported previously for this variety. In two of the three seasons the orchard suffered several frosts during November. Long term climatic data from this area indicated that the risk of early frosts (< -2 degree centigrade) increases as November progresses with a high risk after November 20{sup t}h. In conclusion, the optimal harvesting period for Arbequina in this area should not extend beyond November 20{sup t}h. A rapid harvesting before this date is advisable to avoid the risk of damage caused by early frost in Zaragoza. Hedgerow planting provides an additional advantage in frost-prone areas, because mechanization of operations permits a short harvest period, easier to fit into the optimal harvesting window. (Author) 20 refs.

  17. Short-term visual memory for location in depth: A U-shaped function of time.

    Science.gov (United States)

    Reeves, Adam; Lei, Quan

    2017-10-01

    Short-term visual memory was studied by displaying arrays of four or five numerals, each numeral in its own depth plane, followed after various delays by an arrow cue shown in one of the depth planes. Subjects reported the numeral at the depth cued by the arrow. Accuracy fell with increasing cue delay for the first 500 ms or so, and then recovered almost fully. This dipping pattern contrasts with the usual iconic decay observed for memory traces. The dip occurred with or without a verbal or color-shape retention load on working memory. In contrast, accuracy did not change with delay when a tonal cue replaced the arrow cue. We hypothesized that information concerning the depths of the numerals decays over time in sensory memory, but that cued recall is aided later on by transfer to a visual memory specialized for depth. This transfer is sufficiently rapid with a tonal cue to compensate for the sensory decay, but it is slowed by the need to tag the arrow cue's depth relative to the depths of the numerals, exposing a dip when sensation has decayed and transfer is not yet complete. A model with a fixed rate of sensory decay and varied transfer rates across individuals captures the dip as well as the cue modality effect.

  18. Thermal sterilization of heat-sensitive products using high-temperature short-time sterilization.

    Science.gov (United States)

    Mann, A; Kiefer, M; Leuenberger, H

    2001-03-01

    High-temperature short-time (HTST) sterilization with a continuous-flow sterilizer, developed for this study, was evaluated. The evaluation was performed with respect to (a) the chemical degradation of two heat-sensitive drugs in HTST range (140-160 degrees C) and (b) the microbiological effect of HTST sterilization. Degradation kinetics of two heat-sensitive drugs showed that a high peak temperature sterilization process resulted in less chemical degradation for the same microbiological effect than a low peak temperature process. Both drugs investigated could be sterilized with acceptable degradation at HTST conditions. For the evaluation of the microbiological effect, Bacillus stearothermophilus ATCC 7953 spores were used as indicator bacteria. Indicator spore kinetics (D(T), z value, k, and E(a)), were determined in the HTST range. A comparison between the Bigelow model (z value concept) and the Arrhenius model, used to describe the temperature coefficient of the microbial inactivation, demonstrated that the Bigelow model is more accurate in prediction of D(T) values in the HTST range. The temperature coefficient decreased with increasing temperature. The influence of Ca(2+) ions and pH value on the heat resistance of the indicator spores, which is known under typical sterilization conditions, did not change under HTST conditions.

  19. Effectiveness of mouse minute virus inactivation by high temperature short time treatment technology: a statistical assessment.

    Science.gov (United States)

    Murphy, Marie; Quesada, Guillermo Miro; Chen, Dayue

    2011-11-01

    Viral contamination of mammalian cell cultures in GMP manufacturing facility represents a serious safety threat to biopharmaceutical industry. Such adverse events usually require facility shutdown for cleaning/decontamination, and thus result in significant loss of production and/or delay of product development. High temperature short time (HTST) treatment of culture media has been considered as an effective method to protect GMP facilities from viral contaminations. Log reduction factor (LRF) has been commonly used to measure the effectiveness of HTST treatment for viral inactivation. However, in order to prevent viral contaminations, HTST treatment must inactivate all infectious viruses (100%) in the medium batch since a single virus is sufficient to cause contamination. Therefore, LRF may not be the most appropriate indicator for measuring the effectiveness of HTST in preventing viral contaminations. We report here the use of the probability to achieve complete (100%) virus inactivation to assess the effectiveness of HTST treatment. By using mouse minute virus (MMV) as a model virus, we have demonstrated that the effectiveness of HTST treatment highly depends upon the level of viral contaminants in addition to treatment temperature and duration. We believe that the statistical method described in this report can provide more accurate information about the power and potential limitation of technologies such as HTST in our shared quest to mitigate the risk of viral contamination in manufacturing facilities. Copyright © 2011 The International Alliance for Biological Standardization. Published by Elsevier Ltd. All rights reserved.

  20. Mechanical Properties, Short Time Creep, and Fatigue of an Austenitic Steel

    Directory of Open Access Journals (Sweden)

    Josip Brnic

    2016-04-01

    Full Text Available The correct choice of a material in the process of structural design is the most important task. This study deals with determining and analyzing the mechanical properties of the material, and the material resistance to short-time creep and fatigue. The material under consideration in this investigation is austenitic stainless steel X6CrNiTi18-10. The results presenting ultimate tensile strength and 0.2 offset yield strength at room and elevated temperatures are displayed in the form of engineering stress-strain diagrams. Besides, the creep behavior of the steel is presented in the form of creep curves. The material is consequently considered to be creep resistant at temperatures of 400 °C and 500 °C when subjected to a stress which is less than 0.9 of the yield strength at the mentioned temperatures. Even when the applied stress at a temperature of 600 °C is less than 0.5 of the yield strength, the steel may be considered as resistant to creep. Cyclic tensile fatigue tests were carried out at stress ratio R = 0.25 using a servo-pulser machine and the results were recorded. The analysis shows that the stress level of 434.33 MPa can be adopted as a fatigue limit. The impact energy was also determined and the fracture toughness assessed.

  1. Cerebral blood flow measurement using stable xenon CT with very short inhalation times

    Energy Technology Data Exchange (ETDEWEB)

    Touho, Hajime; Karasawa, Jun; Shishido, Hisashi; Yamada, Keisuke; Shibamoto, Keiji [Osaka Neurological Inst., Toyonaka (Japan)

    1991-02-01

    A noninvasive, simplified method using inhalation of stable xenon (Xe{sup s}) and computed tomographic (CT) scanning to estimate regional cerebral blood flow (rCBF) and regional partition coefficient (r{lambda}) is described. Twenty-four patients with cerebrovascular occlusive disease and six volunteer controls inhaled 30% Xe{sup s} and 70% oxygen for 180 seconds and exhaled for 144 seconds during serial CT scanning without denitrogenation. The end-tidal Xe{sup s} concentration was continuously monitored with a thermoconductivity analyzer to determine the build-up range (A value) and build-up rate constant (K value) for arteries with the curve fitting method. The time-CT number (Hounsfield unit) curve for cerebral tissue during the Xe{sup s} washin and washout phases was used to calculate r{lambda} and rCBF using least squares curve fitting analysis. The resultant r{lambda} and rCBF map demonstrated a reliable distribution between the gray and white matter, and infarcted areas. rCBF was high in gray matter, low in white matter, and much lower in infarcted areas than in white matter. r{lambda} was high in white matter, low in gray matter, and much lower in infarcted areas. Xe{sup s} CT-CBF studies with very short inhalation of 180 seconds is a clinically useful method for evaluation of rCBF in patients with cerebrovascular diseases. (author).

  2. Forecast of electric power market to short-term: a time series approcah

    International Nuclear Information System (INIS)

    Costa, Roberio Neves Pelinca da.

    1994-01-01

    Three different time series approaches are analysed by this dissertation in the Brazilian electricity markert context. The aim is to compare the predictive performance of these approaches from a simulated exercise using the main series of the Brazilian consumption of electricity: Total Consumption, Industrial Consumption, Residencial Consumption and Commercial Consumption. One concludes that these appraches offer an enormous potentiality to the short-term planning system of the Electric Sector. Among the univariate models, the results for the analysed period point out that the forecast produced by Holt-Winter's models are more accurate than those produced by ARIMA and structural models. When explanatory variables are introduced in the last models, one can notice, in general, an improvement in the predictive performance of the models, although there is no sufficient evidence to consider that they are superior to Holt-Winter's models. The models with explanatory variables can be particularly useful, however, when one intends either to build scenarios or to study the effects of some variables on the consumption of electricity. (author). 73 refs., 19 figs., 13 tabs

  3. Application of MOSFET detectors for dosimetry in small animal radiography using short exposure times.

    Science.gov (United States)

    De Lin, Ming; Toncheva, Greta; Nguyen, Giao; Kim, Sangroh; Anderson-Evans, Colin; Johnson, G Allan; Yoshizumi, Terry T

    2008-08-01

    Digital subtraction angiography (DSA) X-ray imaging for small animals can be used for functional phenotyping given its ability to capture rapid physiological changes at high spatial and temporal resolution. The higher temporal and spatial requirements for small-animal imaging drive the need for short, high-flux X-ray pulses. However, high doses of ionizing radiation can affect the physiology. The purpose of this study was to verify and apply metal oxide semiconductor field effect transistor (MOSFET) technology to dosimetry for small-animal diagnostic imaging. A tungsten anode X-ray source was used to expose a tissue-equivalent mouse phantom. Dose measurements were made on the phantom surface and interior. The MOSFETs were verified with thermoluminescence dosimeters (TLDs). Bland-Altman analysis showed that the MOSFET results agreed with the TLD results (bias, 0.0625). Using typical small animal DSA scan parameters, the dose ranged from 0.7 to 2.2 cGy. Application of the MOSFETs in the small animal environment provided two main benefits: (1) the availability of results in near real-time instead of the hours needed for TLD processes and (2) the ability to support multiple exposures with different X-ray techniques (various of kVp, mA and ms) using the same MOSFET. This MOSFET technology has proven to be a fast, reliable small animal dosimetry method for DSA imaging and is a good system for dose monitoring for serial and gene expression studies.

  4. Fecal short-chain fatty acids at different time points after ceftriaxone administration in rats

    Directory of Open Access Journals (Sweden)

    Yu. V. Holota

    2017-02-01

    Full Text Available Short-chain fatty acids (SCFAs are major products of the microbial fermentation of dietary fiber in the colon. Recent studies suggest that these products of microbial metabolism in the gut act as signaling molecules, influence host energy homeostasis and play major immunological roles. In the present study, defined the long-term effects of ceftriaxone administration on the fecal SCFAs concentration in Wistar rats. Ceftriaxone (300 mg/kg, i.m. was administered daily for 14 days. Rats were euthanized in 1, 15 and 56 days after ceftriaxone withdrawal. Caecal weight and fecal concentration of SCFAs by gas chromatography were measured. Ceftriaxone administration induced time-dependent rats’ caecal enlargement through accumulation of undigestable substances. In 1 day after ceftriaxone withdrawal, the concentrations of acetic, propionic, butyric acids and total SCFAs were decreased 2.9-, 13.8-, 8.5-, 4.8-fold (P < 0.05, respectively. Concentration of valeric, isovaleric and caproic acids was below the detectable level. That was accompanied by decreased 4.3-fold anaerobic index and increased the relative amount of acetic acid (P < 0.05. In 56 days, concentration of SCFAs was still below control value but higher than in 1 day (except propionic acid. Anaerobic index was lower 1.3-fold (P < 0.05 vs. control. Conclusion: antibiotic therapy induced long-term disturbance in colonic microbiota metabolic activity.

  5. Improvement of the Original Isolation Procedure for Hormone Studies in Short-Time Culture

    Directory of Open Access Journals (Sweden)

    Mukadder Atmaca

    2005-01-01

    Full Text Available Earlier studies indicated that hormone responsiveness of cells and metabolic activity was lost during various of experimental procedure. In the light of this observation, I aimed to investigate to obtain optimal conditions for short time cultured hepatocytes and also to determine the type of test can be used to evaluate suitablity of hepatocytes for hormones studies. During the isolation period 50 IU/ml and 100 IU/ml collagenase were used. Adrenaline (10-6M was used to measure sensitivity of hepatocytes to hormones and glycogenolsis was measured at the end of 2hr incubation period. Adrenaline significantly increased gylcogenolysis (Control: 0.16±0.01 mg/2hr; Adrenaline: 0.30±0.01 mg/2hr only when the 50 IU/ml collagenase was used and the viability of the cells were over 95%. Viability tests were applied to hepatocytes that obtained by using 50 IU collagenase. Cellular glutathione, methylthiazoltetrazolium reduction, lactatedehdrogenase leakage, ATP level measured to determine viability following the attachment and incubation period. No differences were observed at the end of each period.Altogether, the present study indicated that membrane integrity and metabolic function of the hepatocytes can be improved by modifying slightly the original procedure of Reese and Byard.

  6. Mechanical Properties, Short Time Creep, and Fatigue of an Austenitic Steel.

    Science.gov (United States)

    Brnic, Josip; Turkalj, Goran; Canadija, Marko; Lanc, Domagoj; Krscanski, Sanjin; Brcic, Marino; Li, Qiang; Niu, Jitai

    2016-04-20

    The correct choice of a material in the process of structural design is the most important task. This study deals with determining and analyzing the mechanical properties of the material, and the material resistance to short-time creep and fatigue. The material under consideration in this investigation is austenitic stainless steel X6CrNiTi18-10. The results presenting ultimate tensile strength and 0.2 offset yield strength at room and elevated temperatures are displayed in the form of engineering stress-strain diagrams. Besides, the creep behavior of the steel is presented in the form of creep curves. The material is consequently considered to be creep resistant at temperatures of 400 °C and 500 °C when subjected to a stress which is less than 0.9 of the yield strength at the mentioned temperatures. Even when the applied stress at a temperature of 600 °C is less than 0.5 of the yield strength, the steel may be considered as resistant to creep. Cyclic tensile fatigue tests were carried out at stress ratio R = 0.25 using a servo-pulser machine and the results were recorded. The analysis shows that the stress level of 434.33 MPa can be adopted as a fatigue limit. The impact energy was also determined and the fracture toughness assessed.

  7. Measurement of short transverse relaxation times by pseudo-echo nutation experiments

    Science.gov (United States)

    Ferrari, Maude; Moyne, Christian; Canet, Daniel

    2018-07-01

    Very short NMR transverse relaxation times may be difficult to measure by conventional methods. Nutation experiments constitute an alternative approach. Nutation is, in the rotating frame, the equivalent of precession in the laboratory frame. It consists in monitoring the rotation of magnetization around the radio-frequency (rf) field when on-resonance conditions are fulfilled. Depending on the amplitude of the rf field, nutation may be sensitive to the two relaxation rates R1 and R2. A full theoretical development has been worked out for demonstrating how these two relaxation rates could be deduced from a simple nutation experiment, noticing however that inhomogeneity of the rf field may lead to erroneous results. This has led us to devise new experiments which are the equivalent of echo techniques in the rotating frame (pseudo spin-echo nutation experiment and pseudo gradient-echo experiment). Full equations of motion have been derived. Although complicated, they indicate that the sum of the two relaxation rates can be obtained very accurately and not altered by rf field inhomogeneity. This implies however an appropriate data processing accounting for the oscillations which are superposed to the echo decays and, anyway, theoretically predicted. A series of experiments has been carried out for different values of the rf field amplitude on samples of water doped with a paramagnetic compound at different concentrations. Pragmatically, as R1 can be easily measured by conventional methods, its value is entered in the data processing algorithm which then returns exclusively the value of the transverse relaxation time. Very consistent results are obtained that way.

  8. INFLUENCE OF RAMADAN FASTING ON ANAEROBIC PERFORMANCE AND RECOVERY FOLLOWING SHORT TIME HIGH INTENSITY EXERCISE

    Directory of Open Access Journals (Sweden)

    Umid Karli

    2007-12-01

    Full Text Available The aim of this study was to investigate the effects of Ramadan fasting on anaerobic power and capacity and the removal rate of lactate after short time high intensity exercise in power athletes. Ten male elite power athletes (2 wrestlers, 7 sprinters and 1 thrower, aged 20-24 yr, mean age 22.30 ± 1.25 yr participated in this study. The subjects were tested three times [3 days before the beginning of Ramadan (Pre-RF, the last 3 days of Ramadan (End-RF and the last 3 days of the 4th week after the end of Ramadan (After-RF]. Anaerobic power and capacity were measured by using the Wingate Anaerobic Test (WAnT at Pre-RF, End-RF and After- RF. Capillary blood samples for lactate analyses and heart rate recordings were taken at rest, immediately after WAnT and throughout the recovery period. Repeated measures of ANOVA indicated that there were no significant changes in body weight, body mass index, fat free mass, percentage of body fat, daily sleeping time and daily caloric intake associated with Ramadan fasting. No significant changes were found in total body water either, but urinary density measured at End-RF was significantly higher than After-RF. Similarity among peak HR and peak LA values at Pre-RF, End- RF and After-RF demonstrated that cardiovascular and metabolic stress caused by WAnT was not affected by Ramadan fasting. In addition, no influence of Ramadan fasting on anaerobic power and capacity and removal rate of LA from blood following high intensity exercise was observed. The results of this study revealed that if strength-power training is performed regularly and daily food intake, body fluid balance and daily sleeping time are maintained as before Ramadan, Ramadan fasting will not have adverse effects on body composition, anaerobic power and capacity, and LA metabolism during and after high intensity exercise in power athletes

  9. Establishing conditions for the storage and elution of rabies virus RNA using FTA(®) cards.

    Science.gov (United States)

    Sakai, Takeo; Ishii, Ayako; Segawa, Takao; Takagi, Yukihiko; Kobayashi, Yuki; Itou, Takuya

    2015-04-01

    The Flinders Technology Associates filter paper cards (FTA(®) cards) can be used to store nucleic acid from various samples and are easily portable. However, RNA is physicochemically unstable compared with DNA, and appropriate methods have not been established for storage and extraction of RNA from FTA(®) cards. The present study investigated the optimum conditions for storage and elution of viral RNA (vRNA) using rabies virus (RABV) applied to FTA(®) cards. When TE buffer was used, the elution rates of vRNA increased with the length of the elution time. When the cards were stored at -80 °C or -20 °C, vRNA was stable over 3 months. Degradation of vRNAs occurred following storage at 4 °C and room temperature, suggesting that RNA should be extracted from cards as soon as possible if no freezer is available. When we tried to amplify vRNA from RABV-infected animal brains applied to FTA(®) cards and stored at -80 °C for 6 months, we did not detect any amplified products with the primer set for 964 bp of RABV N gene. However, we were able to detect amplified products by increasing the elution time of vRNA from FTA(®) cards from 30 min to 24 hr or by changing the primer sets to amplify 290 bp of N gene. Thus, we recommend extending the elution time for damaged or low concentration samples in FTA(®) cards.

  10. Time-Based Loss in Visual Short-Term Memory Is from Trace Decay, Not Temporal Distinctiveness

    Science.gov (United States)

    Ricker, Timothy J.; Spiegel, Lauren R.; Cowan, Nelson

    2014-01-01

    There is no consensus as to why forgetting occurs in short-term memory tasks. In past work, we have shown that forgetting occurs with the passage of time, but there are 2 classes of theories that can explain this effect. In the present work, we investigate the reason for time-based forgetting by contrasting the predictions of temporal…

  11. [Possibilities in the differential diagnosis of brain neoplasms using the long and short time sequences of proton magnetic resonance spectroscopy

    NARCIS (Netherlands)

    Gajewicz, W.; Goraj, B.M.

    2004-01-01

    Currently to perform proton magnetic resonance spectroscopy (1H MRS) with single voxel spectroscopy (SVS) technique long and/or short echo time sequences are used in order to provide complementary information. PURPOSE: The aim of the study was to compare the usefulness of STEAM (time echo, TE, 20

  12. Functional Nanoarchitectures For Enhanced Drug Eluting Stents

    Science.gov (United States)

    Saleh, Yomna E.; Gepreel, Mohamed A.; Allam, Nageh K.

    2017-01-01

    Different strategies have been investigated to allow for optimum duration and conditions for endothelium healing through the enhancement of coronary stents. In this study, a nanoarchitectured system is proposed as a surface modification for drug eluting stents. Highly oriented nanotubes were vertically grown on the surface of a new Ni-free biocompatible Ti-based alloy, as a potential material for self-expandable stents. The fabricated nanotubes were self-grown from the potential stent substrate, which are also proposed to enhance endothelial proliferation while acting as drug reservoir to hinder Vascular Smooth Muscle Cells (VSMC) proliferation. Two morphologies were synthesized to investigate the effect of structure homogeneity on the intended application. The material was characterized by field-emission scanning electron microscope (FESEM), X-ray diffraction (XRD), Raman spectroscopy, energy dispersive X-ray spectroscopy (EDX), and X-ray photoelectron spectroscopy (XPS). Nanoindentation technique was used to study the mechanical properties of the fabricated material. Cytotoxicity and proliferation studies were performed and compared for the two fabricated nanoarchitectures, versus smooth untextured samples, using in-vitro cultured endothelial cells. Finally, the drug loading capacity was experimentally studied and further supported by computational modeling of the release profile.

  13. Short-Time Structural Stability of Compressible Vortex Sheets with Surface Tension

    Science.gov (United States)

    Stevens, Ben

    2016-11-01

    Assume we start with an initial vortex-sheet configuration which consists of two inviscid fluids with density bounded below flowing smoothly past each other, where a strictly positive fixed coefficient of surface tension produces a surface tension force across the common interface, balanced by the pressure jump. We model the fluids by the compressible Euler equations in three space dimensions with a very general equation of state relating the pressure, entropy and density such that the sound speed is positive. We prove that, for a short time, there exists a unique solution of the equations with the same structure. The mathematical approach consists of introducing a carefully chosen artificial viscosity-type regularisation which allows one to linearise the system so as to obtain a collection of transport equations for the entropy, pressure and curl together with a parabolic-type equation for the velocity which becomes fairly standard after rotating the velocity according to the interface normal. We prove a high order energy estimate for the non-linear equations that is independent of the artificial viscosity parameter which allows us to send it to zero. This approach loosely follows that introduced by Shkoller et al. in the setting of a compressible liquid-vacuum interface. Although already considered by Coutand et al. [10] and Lindblad [17], we also make some brief comments on the case of a compressible liquid-vacuum interface, which is obtained from the vortex sheets problem by replacing one of the fluids by vacuum, where it is possible to obtain a structural stability result even without surface tension.

  14. Classification of brain tumours using short echo time 1H MR spectra

    Science.gov (United States)

    Devos, A.; Lukas, L.; Suykens, J. A. K.; Vanhamme, L.; Tate, A. R.; Howe, F. A.; Majós, C.; Moreno-Torres, A.; van der Graaf, M.; Arús, C.; Van Huffel, S.

    2004-09-01

    The purpose was to objectively compare the application of several techniques and the use of several input features for brain tumour classification using Magnetic Resonance Spectroscopy (MRS). Short echo time 1H MRS signals from patients with glioblastomas ( n = 87), meningiomas ( n = 57), metastases ( n = 39), and astrocytomas grade II ( n = 22) were provided by six centres in the European Union funded INTERPRET project. Linear discriminant analysis, least squares support vector machines (LS-SVM) with a linear kernel and LS-SVM with radial basis function kernel were applied and evaluated over 100 stratified random splittings of the dataset into training and test sets. The area under the receiver operating characteristic curve (AUC) was used to measure the performance of binary classifiers, while the percentage of correct classifications was used to evaluate the multiclass classifiers. The influence of several factors on the classification performance has been tested: L2- vs. water normalization, magnitude vs. real spectra and baseline correction. The effect of input feature reduction was also investigated by using only the selected frequency regions containing the most discriminatory information, and peak integrated values. Using L2-normalized complete spectra the automated binary classifiers reached a mean test AUC of more than 0.95, except for glioblastomas vs. metastases. Similar results were obtained for all classification techniques and input features except for water normalized spectra, where classification performance was lower. This indicates that data acquisition and processing can be simplified for classification purposes, excluding the need for separate water signal acquisition, baseline correction or phasing.

  15. Estimating return periods of extreme values from relatively short time series of winds

    Science.gov (United States)

    Jonasson, Kristjan; Agustsson, Halfdan; Rognvaldsson, Olafur; Arfeuille, Gilles

    2013-04-01

    An important factor for determining the prospect of individual wind farm sites is the frequency of extreme winds at hub height. Here, extreme winds are defined as the value of the highest 10 minutes averaged wind speed with a 50 year return period, i.e. annual exceeding probability of 2% (Rodrigo, 2010). A frequently applied method to estimate winds in the lowest few hundred meters above ground is to extrapolate observed 10-meter winds logarithmically to higher altitudes. Recent study by Drechsel et al. (2012) showed however that this methodology is not as accurate as interpolating simulated results from the global ECMWF numerical weather prediction (NWP) model to the desired height. Observations of persistent low level jets near Colima in SW-Mexico also show that the logarithmic approach can give highly inaccurate results for some regions (Arfeuille et al., 2012). To address these shortcomings of limited, and/or poorly representative, observations and extrapolations of winds one can use NWP models to dynamically scale down relatively coarse resolution atmospheric analysis. In the case of limited computing resources one has typically to make a compromise between spatial resolution and the duration of the simulated period, both of which can limit the quality of the wind farm siting. A common method to estimate maximum winds is to fit an extreme value distribution (e.g. Gumbel, gev or Pareto) to the maximum values of each year of available data, or the tail of these values. If data are only available for a short period, e.g. 10 or 15 years, then this will give a rather inaccurate estimate. It is possible to deal with this problem by utilizing monthly or weekly maxima, but this introduces new problems: seasonal variation, autocorrelation of neighboring values, and increased discrepancy between data and fitted distribution. We introduce a new method to estimate return periods of extreme values of winds at hub height from relatively short time series of winds, simulated

  16. Production and setting of fractional elution facility for recovery of useful rare metals from seawater

    International Nuclear Information System (INIS)

    Seko, Noriaki; Kasai, Noboru; Tamada, Masao; Hasegawa, Shin; Katakai, Akio

    2005-01-01

    In September 1999, we have soaked 200 kg of fibrous amidoxime absorbents, synthesized by radiation-induced graft polymerization, into seawater to evaluate their performance. Fractional elution facility was set effectively to elute the rare metals on adsorbents in Mutsu-Establishment. This facility consists of two parts of pre-washing and elution. The present report dealt with planning, manufacture and setting of fractional facility. Marine organism and slime on adsorbent cassette (290 x 295 x 160 mm) were washed out and every 72 cassettes were set in elution unit (1210 x 1210 x H1460 mm) with nonwoven materials as a packing to avoid elution loss. In the elution process alkaline and alkaline earth metals were eluted with low concentration hydrochloric acid (0.01M) and rare metals were eluted with high concentration (0.5 M) after the packing of elution unit into fractional elution facility. Adsorbent cassettes were regenerated with alkaline solution after elution procedure. (author)

  17. Evaluation on elution feature of bentonite buffer materials

    Energy Technology Data Exchange (ETDEWEB)

    Ishikawa, Hirohisa; Kanno, Takeshi; Matsumoto, Kazuhiro

    1997-09-01

    In order to evaluate long term physical stability of artificial barrier in land disposal of high level radioactive wastes, it is necessary to know quantitatively elution behavior of buffering materials from disposal road (or cavity) to circumferential rock crack. When elution of the buffer material occurs on large scale, amount of bentonite in the disposal road (or cavity) reduces and reduction of various functions expected to the buffer materials is presumed. According to specification examples of road transverse arrangement and disposal vertical arrangement systems, evaluation on elution amount of the buffer materials at disposal environment was conducted. Opening width of rock crack in the disposal environment was supposed to be 0.5 mm. As a result, obtained mass elution ratios of the buffer materials due to extrusion phenomenon were 0.04 to 0.2% after 10,000 year and 2 to 12% after 1,000,000 years. (G.K.)

  18. Characterization of CRUDE OILS and petroleum products: (i) elution ...

    African Journals Online (AJOL)

    Characterization of CRUDE OILS and petroleum products: (i) elution liquid chromatographic separation and gas chromatographic analysis of crude oils and petroleum products. E.O. Odebunmi, E.A. Ogunsakin, P.E.P. Ilukhor ...

  19. Kuldkaru elutöö eest / Endel Link

    Index Scriptorium Estoniae

    Link, Endel

    2001-01-01

    Ameerika näitleja Kirk Douglas (1916), kellele seekordsel Berlinalel antakse elutöö eest Kuldkaru. Austamisõhtul näidatakse teda Stanley Kubricku kaua keelu all olnud filmis "Tee kuulsusele " ("Paths of Glory") : 1957

  20. Construction of a flash-photolysis apparatus having a short discharge time

    International Nuclear Information System (INIS)

    Devillers, C.

    1964-01-01

    Flash photolysis aims at reaching directly the primary mechanisms resulting from the action of light on an absorbent matter. This makes it necessary to produce a flash as short and as bright as possible. Our main effort was directed towards reducing the duration of the flash by decreasing the self-inductance of the discharge circuit. A description of this circuit and study of the characteristics of the apparatus are followed by a short description of the two analytical methods: flash spectrography and absorption spectrophotometry at a given wave-length. (author) [fr

  1. Variational data assimilation for the optimized ozone initial state and the short-time forecasting

    Directory of Open Access Journals (Sweden)

    S.-Y. Park

    2016-03-01

    Full Text Available In this study, we apply the four-dimensional variational (4D-Var data assimilation to optimize initial ozone state and to improve the predictability of air quality. The numerical modeling systems used for simulations of atmospheric condition and chemical formation are the Weather Research and Forecasting (WRF model and the Community Multiscale Air Quality (CMAQ model. The study area covers the capital region of South Korea, where the surface measurement sites are relatively evenly distributed. The 4D-Var code previously developed for the CMAQ model is modified to consider background error in matrix form, and various numerical tests are conducted. The results are evaluated with an idealized covariance function for the appropriateness of the modified codes. The background error is then constructed using the NMC method with long-term modeling results, and the characteristics of the spatial correlation scale related to local circulation are analyzed. The background error is applied in the 4D-Var research, and a surface observational assimilation is conducted to optimize the initial concentration of ozone. The statistical results for the 12 h assimilation periods and the 120 observatory sites show a 49.4 % decrease in the root mean squared error (RMSE, and a 59.9 % increase in the index of agreement (IOA. The temporal variation of spatial distribution of the analysis increments indicates that the optimized initial state of ozone concentration is transported to inland areas by the clockwise-rotating local circulation during the assimilation windows. To investigate the predictability of ozone concentration after the assimilation window, a short-time forecasting is carried out. The ratios of the RMSE (root mean squared error with assimilation versus that without assimilation are 8 and 13 % for the +24 and +12 h, respectively. Such a significant improvement in the forecast accuracy is obtained solely by using the optimized initial state. The potential

  2. Technical Note: Deep learning based MRAC using rapid ultra-short echo time imaging.

    Science.gov (United States)

    Jang, Hyungseok; Liu, Fang; Zhao, Gengyan; Bradshaw, Tyler; McMillan, Alan B

    2018-05-15

    In this study, we explore the feasibility of a novel framework for MR-based attenuation correction for PET/MR imaging based on deep learning via convolutional neural networks, which enables fully automated and robust estimation of a pseudo CT image based on ultrashort echo time (UTE), fat, and water images obtained by a rapid MR acquisition. MR images for MRAC are acquired using dual echo ramped hybrid encoding (dRHE), where both UTE and out-of-phase echo images are obtained within a short single acquisition (35 sec). Tissue labeling of air, soft tissue, and bone in the UTE image is accomplished via a deep learning network that was pre-trained with T1-weighted MR images. UTE images are used as input to the network, which was trained using labels derived from co-registered CT images. The tissue labels estimated by deep learning are refined by a conditional random field based correction. The soft tissue labels are further separated into fat and water components using the two-point Dixon method. The estimated bone, air, fat, and water images are then assigned appropriate Hounsfield units, resulting in a pseudo CT image for PET attenuation correction. To evaluate the proposed MRAC method, PET/MR imaging of the head was performed on 8 human subjects, where Dice similarity coefficients of the estimated tissue labels and relative PET errors were evaluated through comparison to a registered CT image. Dice coefficients for air (within the head), soft tissue, and bone labels were 0.76±0.03, 0.96±0.006, and 0.88±0.01. In PET quantification, the proposed MRAC method produced relative PET errors less than 1% within most brain regions. The proposed MRAC method utilizing deep learning with transfer learning and an efficient dRHE acquisition enables reliable PET quantification with accurate and rapid pseudo CT generation. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  3. Nickel elution properties of contemporary interatrial shunt closure devices.

    Science.gov (United States)

    Verma, Divya Ratan; Khan, Muhammad F; Tandar, Anwar; Rajasekaran, Namakkal S; Neuharth, Renée; Patel, Amit N; Muhlestein, Joseph B; Badger, Rodney S

    2015-02-01

    We sought to compare nickel elution properties of contemporary interatrial shunt closure devices in vitro. There are two United States Food and Drug Administration (FDA)-approved devices for percutaneous closure of secundum atrial septal defect: the Amplatzer septal occluder (ASO; St Jude Medical Corporation) and Gore Helex septal occluder (HSO; W.L. Gore & Associates). The new Gore septal occluder (GSO) device is in clinical trials. These are also used off-label for patent foramen ovale closure in highly selected patients. These devices have high nickel content. Nickel allergy is the most common reason for surgical device explantation. Nickel elution properties of contemporary devices remain unknown. We compared nickel elution properties of 4 devices - ASO, GSO, HSO, and sternal wire (SW) - while Dulbecco's phosphate-buffered saline (DPBS) served as control. Three samples of each device were submerged in DPBS. Nickel content was measured at 14 intervals over 90 days. Nickel elution at 24 hours, compared to control (0.005 ± 0.0 mg/L), was significantly higher for ASO (2.98 ± 1.65 mg/L; P=.04) and SW (0.03 ± 0.014 mg/L; P=.03). Nickel levels at 90 days, compared to control (0.005 ± 0.0 mg/L) and adjusting for multiple comparisons, were significantly higher for ASO (19.80 ± 2.30 mg/L; P=.01) and similar for HSO (P=.34), GSO (P=.34), and SW (P=.34). ASO had significantly higher nickel elution compared to HSO, GSO, and SW (P=.01). There is substantial variability in nickel elution; devices with less exposed nickel (HSO and GSO) have minimal elution. The safety of low nickel elution devices in patients with nickel allergy needs to be evaluated in prospective trials.

  4. Application of Grey Model GM(1, 1) to Ultra Short-Term Predictions of Universal Time

    Science.gov (United States)

    Lei, Yu; Guo, Min; Zhao, Danning; Cai, Hongbing; Hu, Dandan

    2016-03-01

    A mathematical model known as one-order one-variable grey differential equation model GM(1, 1) has been herein employed successfully for the ultra short-term (advantage is that the developed method is easy to use. All these reveal a great potential of the GM(1, 1) model for UT1-UTC predictions.

  5. Cognitive Abilities Explaining Age-Related Changes in Time Perception of Short and Long Durations

    Science.gov (United States)

    Zelanti, Pierre S.; Droit-Volet, Sylvie

    2011-01-01

    The current study investigated how the development of cognitive abilities explains the age-related changes in temporal judgment over short and long duration ranges from 0.5 to 30 s. Children (5- and 9-year-olds) as well as adults were given a temporal bisection task with four different duration ranges: a duration range shorter than 1 s, two…

  6. Time Perspective and Identity Formation: Short-Term Longitudinal Dynamics in College Students

    Science.gov (United States)

    Luyckx, Koen; Lens, Willy; Smits, Ilse; Goossens, Luc

    2010-01-01

    Planning for the future and developing a personalized identity are conceived of as important developmental tasks that adolescents and emerging adults are confronted with on the pathway to adulthood. The present study set out to examine whether both tasks develop in tandem by using a short-term longitudinal dataset consisting of 371 college…

  7. Development of Speech Fluency over a Short Period of Time: Effects of Pedagogic Intervention

    Science.gov (United States)

    Tavakoli, Parvaneh; Campbell, Colin; McCormack, Joan

    2016-01-01

    This study investigates the effects of a short-term pedagogic intervention on development of second language (L2) fluency among learners studying English for academic purposes at a UK university. It also examines the interaction between development of fluency and complexity and accuracy. Through a pretest and posttest design, data were collected…

  8. The study of the possibility to use CAMEX chips in collider experiments with short bunch crossing time

    International Nuclear Information System (INIS)

    Aulchenko, V.M.; Chilingarov, A.G.; Serbo, V.V.; Titov, V.M.

    1993-01-01

    The study of the possibility to use CAMEX chips in several systems of the detector KEDR at the e + e - collider VEPP-4M was performed. The relatively short bunch crossing time at VEPP-4M 60 ns leads to some problems with the use of CAMEX in the standard mode. The different ways to overcome these difficulties are investigated and compared. (orig.)

  9. 25 CFR 26.30 - Does the Job Training Program provide part-time training or short-term training?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Does the Job Training Program provide part-time training or short-term training? 26.30 Section 26.30 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HUMAN SERVICES JOB PLACEMENT AND TRAINING PROGRAM Training Services § 26.30 Does the Job Training...

  10. Short echo time proton spectroscopy of the brain in healthy volunteers using an insert gradient head coil

    DEFF Research Database (Denmark)

    Gideon, P; Danielsen, E R; Schneider, M

    1995-01-01

    An insert gradient head coil with built-in X, Y, and Z gradients was used for localized proton spectroscopy in the brain of healthy volunteers, using short echo time stimulated echo acquisition mode (STEAM) sequences. Volume of interest size was 3.4 ml, repetition time was 6.0 s, and echo times...... were 10 and 20 ms, respectively. Good quality proton spectra with practically no eddy current artefacts were acquired allowing observation of strongly coupled compounds, and compounds with short T2 relaxation times. The gradient head coil thus permits further studies of compounds such as glutamine....../glutamate and myo-inositols. These compounds were more prominent within grey matter than within white matter. Rough estimations of metabolite concentrations using water as an internal standard were in good agreement with previous reports....

  11. Short-course versus long-course chemoradiation in rectal cancer--time to change strategies?

    Science.gov (United States)

    Palta, Manisha; Willett, Christopher G; Czito, Brian G

    2014-09-01

    There is significant debate regarding the optimal neoadjuvant regimen for resectable rectal cancer patients. Short-course radiotherapy, a standard approach throughout most of northern Europe, is generally defined as 25 Gy in 5 fractions over the course of 1 week without the concurrent administration of chemotherapy. Long-course radiotherapy is typically defined as 45 to 50.4 Gy in 25-28 fractions with the administration of concurrent 5-fluoropyrimidine-based chemotherapy and is the standard approach in other parts of Europe and the United States. At present, two randomized trials have compared outcomes for short course radiotherapy with long-course chemoradiation showing no difference in respective study endpoints. Late toxicity data are lacking given limited follow-up. Although the ideal neoadjuvant regimen is controversial, our current bias is long-course chemoradiation to treat patients with locally advanced, resectable rectal cancer.

  12. Age and admission times as predictive factors for failure of admissions to discharge-stream short-stay units.

    Science.gov (United States)

    Shetty, Amith L; Shankar Raju, Savitha Banagar; Hermiz, Arsalan; Vaghasiya, Milan; Vukasovic, Matthew

    2015-02-01

    Discharge-stream emergency short-stay units (ESSU) improve ED and hospital efficiency. Age of patients and time of hospital presentations have been shown to correlate with increasing complexity of care. We aim to determine whether an age and time cut-off could be derived to subsequently improve short-stay unit success rates. We conducted a retrospective audit on 6703 (5522 inclusions) patients admitted to our discharge-stream short-stay unit. Patients were classified as appropriate or inappropriate admissions, and deemed successful if discharged out of the unit within 24 h; and failures if they needed inpatient admission into the hospital. We calculated short-stay unit length of stay for patients in each of these groups. A 15% failure rate was deemed as acceptable key performance indicator (KPI) for our unit. There were 197 out of 4621 (4.3%, 95% CI 3.7-4.9%) patients up to the age of 70 who failed admission to ESSU compared with 67 out of 901 (7.4%, 95% CI 5.9-9.3%, P 70 years of age have higher rates of failure after admission to discharge-stream ESSU. Although in appropriately selected discharge-stream patients, no age group or time-band of presentation was associated with increased failure rate beyond the stipulated KPI. © 2014 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine.

  13. A general dead-time correction method based on live-time stamping. Application to the measurement of short-lived radionuclides.

    Science.gov (United States)

    Chauvenet, B; Bobin, C; Bouchard, J

    2017-12-01

    Dead-time correction formulae are established in the general case of superimposed non-homogeneous Poisson processes. Based on the same principles as conventional live-timed counting, this method exploits the additional information made available using digital signal processing systems, and especially the possibility to store the time stamps of live-time intervals. No approximation needs to be made to obtain those formulae. Estimates of the variances of corrected rates are also presented. This method is applied to the activity measurement of short-lived radionuclides. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Role of short-time acoustic temporal fine structure cues in sentence recognition for normal-hearing listeners.

    Science.gov (United States)

    Hou, Limin; Xu, Li

    2018-02-01

    Short-time processing was employed to manipulate the amplitude, bandwidth, and temporal fine structure (TFS) in sentences. Fifty-two native-English-speaking, normal-hearing listeners participated in four sentence-recognition experiments. Results showed that recovered envelope (E) played an important role in speech recognition when the bandwidth was > 1 equivalent rectangular bandwidth. Removing TFS drastically reduced sentence recognition. Preserving TFS greatly improved sentence recognition when amplitude information was available at a rate ≥ 10 Hz (i.e., time segment ≤ 100 ms). Therefore, the short-time TFS facilitates speech perception together with the recovered E and works with the coarse amplitude cues to provide useful information for speech recognition.

  15. A comparative analysis of short-range travel time prediction methods

    NARCIS (Netherlands)

    Huisken, Giovanni; van Berkum, Eric C.

    2003-01-01

    Increasing car mobility has lead to an increasing demand for traffic information. This contribution deals with information about travel times. When car drivers are provided with this type of information, the travel times should ideally be the times that they will encounter. As a result travel times

  16. Time-resolved neuroimaging of visual short term memory consolidation by post-perceptual attention shifts.

    Science.gov (United States)

    Hecht, Marcus; Thiemann, Ulf; Freitag, Christine M; Bender, Stephan

    2016-01-15

    Post-perceptual cues can enhance visual short term memory encoding even after the offset of the visual stimulus. However, both the mechanisms by which the sensory stimulus characteristics are buffered as well as the mechanisms by which post-perceptual selective attention enhances short term memory encoding remain unclear. We analyzed late post-perceptual event-related potentials (ERPs) in visual change detection tasks (100ms stimulus duration) by high-resolution ERP analysis to elucidate these mechanisms. The effects of early and late auditory post-cues (300ms or 850ms after visual stimulus onset) as well as the effects of a visual interference stimulus were examined in 27 healthy right-handed adults. Focusing attention with post-perceptual cues at both latencies significantly improved memory performance, i.e. sensory stimulus characteristics were available for up to 850ms after stimulus presentation. Passive watching of the visual stimuli without auditory cue presentation evoked a slow negative wave (N700) over occipito-temporal visual areas. N700 was strongly reduced by a visual interference stimulus which impeded memory maintenance. In contrast, contralateral delay activity (CDA) still developed in this condition after the application of auditory post-cues and was thereby dissociated from N700. CDA and N700 seem to represent two different processes involved in short term memory encoding. While N700 could reflect visual post processing by automatic attention attraction, CDA may reflect the top-down process of searching selectively for the required information through post-perceptual attention. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. Clinical observation of one time short-pulse pattern scan laser pan-retinal photocoagulation for proliferative diabetic retinopathy

    Directory of Open Access Journals (Sweden)

    Xin Liu

    2016-04-01

    Full Text Available AIM: To investigate the clinical efficacy and benefit of short-pulse pattern scan laser(PASCALphotocoagulation for proliferative diabetic retinopathy(PDR.METHODS:Twenty-eight PDR patients(42 eyesunderwent short-pulse PASCAL pan-retinal photocoagulation(PRPwere analyzed.The best corrected visual acuity was ≥0.1 in 36 eyes, RESULTS: All the cases had no pain during the short-pulse PASCAL treatment.One year after treatments,the final visual acuity was improved in 6 eyes,kept stable in 28 eyes and decreased in 8 eyes; neovascularization were regressed in 18 eyes(43%, stable in 12 eyes(29%, uncontrolled in 12 eyes(29%. Five eyes(12%received vitrectomy due to vitreous hemorrhage.Compared with before operation, retina thickness in central fovea of macula and visual field had no obvious change after one-time PASCAL PRP(P>0.05. CONCLUSION:The one-time short-pulse PASCAL PRP could stabilize the progress of PDR safely, effectively and simply.

  18. Increasing Short-Stay Unplanned Hospital Admissions among Children in England; Time Trends Analysis ’97–‘06

    Science.gov (United States)

    Saxena, Sonia; Bottle, Alex; Gilbert, Ruth; Sharland, Mike

    2009-01-01

    Background Timely care by general practitioners in the community keeps children out of hospital and provides better continuity of care. Yet in the UK, access to primary care has diminished since 2004 when changes in general practitioners' contracts enabled them to ‘opt out’ of providing out-of-hours care and since then unplanned pediatric hospital admission rates have escalated, particularly through emergency departments. We hypothesised that any increase in isolated short stay admissions for childhood illness might reflect failure to manage these cases in the community over a 10 year period spanning these changes. Methods and Findings We conducted a population based time trends study of major causes of hospital admission in children 2 days. By 2006, 67.3% of all unplanned admissions were isolated short stays <2 days. The increases in admission rates were greater for common non-infectious than infectious causes of admissions. Conclusions Short stay unplanned hospital admission rates in young children in England have increased substantially in recent years and are not accounted for by reductions in length of in-hospital stay. The majority are isolated short stay admissions for minor illness episodes that could be better managed by primary care in the community and may be evidence of a failure of primary care services. PMID:19829695

  19. Bioresorbable polymer coated drug eluting stent: a model study.

    Science.gov (United States)

    Rossi, Filippo; Casalini, Tommaso; Raffa, Edoardo; Masi, Maurizio; Perale, Giuseppe

    2012-07-02

    In drug eluting stent technologies, an increased demand for better control, higher reliability, and enhanced performances of drug delivery systems emerged in the last years and thus offered the opportunity to introduce model-based approaches aimed to overcome the remarkable limits of trial-and-error methods. In this context a mathematical model was studied, based on detailed conservation equations and taking into account the main physical-chemical mechanisms involved in polymeric coating degradation, drug release, and restenosis inhibition. It allowed highlighting the interdependence between factors affecting each of these phenomena and, in particular, the influence of stent design parameters on drug antirestenotic efficacy. Therefore, the here-proposed model is aimed to simulate the diffusional release, for both in vitro and the in vivo conditions: results were verified against various literature data, confirming the reliability of the parameter estimation procedure. The hierarchical structure of this model also allows easily modifying the set of equations describing restenosis evolution to enhance model reliability and taking advantage of the deep understanding of physiological mechanisms governing the different stages of smooth muscle cell growth and proliferation. In addition, thanks to its simplicity and to the very low system requirements and central processing unit (CPU) time, our model allows obtaining immediate views of system behavior.

  20. Time-dependent screening of a positive charge distribution in metals: Excitons on an ultra-short time scale

    OpenAIRE

    Schöne, Wolf-Dieter; Ekardt, Walter

    2000-01-01

    Experiments determining the lifetime of excited electrons in crystalline copper reveal states which cannot be interpreted as Bloch states [S. Ogawa {\\it et al.}, Phys. Rev. B {\\bf 55}, 10869 (1997)]. In this article we propose a model which explains these states as transient excitonic states in metals. The physical background of transient excitons is the finite time a system needs to react to an external perturbation, in other words, the time which is needed to build up a polarization cloud. ...

  1. Efficient Computation of Multiscale Entropy over Short Biomedical Time Series Based on Linear State-Space Models

    Directory of Open Access Journals (Sweden)

    Luca Faes

    2017-01-01

    Full Text Available The most common approach to assess the dynamical complexity of a time series across multiple temporal scales makes use of the multiscale entropy (MSE and refined MSE (RMSE measures. In spite of their popularity, MSE and RMSE lack an analytical framework allowing their calculation for known dynamic processes and cannot be reliably computed over short time series. To overcome these limitations, we propose a method to assess RMSE for autoregressive (AR stochastic processes. The method makes use of linear state-space (SS models to provide the multiscale parametric representation of an AR process observed at different time scales and exploits the SS parameters to quantify analytically the complexity of the process. The resulting linear MSE (LMSE measure is first tested in simulations, both theoretically to relate the multiscale complexity of AR processes to their dynamical properties and over short process realizations to assess its computational reliability in comparison with RMSE. Then, it is applied to the time series of heart period, arterial pressure, and respiration measured for healthy subjects monitored in resting conditions and during physiological stress. This application to short-term cardiovascular variability documents that LMSE can describe better than RMSE the activity of physiological mechanisms producing biological oscillations at different temporal scales.

  2. Short-time dynamics of lysozyme solutions with competing short-range attraction and long-range repulsion: Experiment and theory

    Science.gov (United States)

    Riest, Jonas; Nägele, Gerhard; Liu, Yun; Wagner, Norman J.; Godfrin, P. Douglas

    2018-02-01

    Recently, atypical static features of microstructural ordering in low-salinity lysozyme protein solutions have been extensively explored experimentally and explained theoretically based on a short-range attractive plus long-range repulsive (SALR) interaction potential. However, the protein dynamics and the relationship to the atypical SALR structure remain to be demonstrated. Here, the applicability of semi-analytic theoretical methods predicting diffusion properties and viscosity in isotropic particle suspensions to low-salinity lysozyme protein solutions is tested. Using the interaction potential parameters previously obtained from static structure factor measurements, our results of Monte Carlo simulations representing seven experimental lysoyzme samples indicate that they exist either in dispersed fluid or random percolated states. The self-consistent Zerah-Hansen scheme is used to describe the static structure factor, S(q), which is the input to our calculation schemes for the short-time hydrodynamic function, H(q), and the zero-frequency viscosity η. The schemes account for hydrodynamic interactions included on an approximate level. Theoretical predictions for H(q) as a function of the wavenumber q quantitatively agree with experimental results at small protein concentrations obtained using neutron spin echo measurements. At higher concentrations, qualitative agreement is preserved although the calculated hydrodynamic functions are overestimated. We attribute the differences for higher concentrations and lower temperatures to translational-rotational diffusion coupling induced by the shape and interaction anisotropy of particles and clusters, patchiness of the lysozyme particle surfaces, and the intra-cluster dynamics, features not included in our simple globular particle model. The theoretical results for the solution viscosity, η, are in qualitative agreement with our experimental data even at higher concentrations. We demonstrate that semi

  3. Advantages of novel BioMimeTM Sirolimus Eluting Coronary Stent system. Moving towards biomimicry.

    Science.gov (United States)

    Upendra, K; Sanjeev, B

    2012-02-01

    Since the first reported use of percutaneous transluminal coronary angioplasty (PTCA), advancements in interventional cardiology arena have been fast paced. Within the last ten years, these developments have been exponential. Developers & clinicians are fast adapting from the learning curve awarded by the time course of DES evolution. In that light BioMimeTM Sirolimus Eluting Coronary Stent comes as a fresh thought in taking stents towards a biomimicry concept. The stent is built on an ultra-low strut thickness (65 µm) cobalt chromium stent platform, using an intelligent hybrid of close and open cells allowing for morphology mediated expansion, employs a well known anti-proliferative - Sirolimus that elutes from a biodegradable co-polymer formulation in 30 days and ensures high coating integrity and low coating thickness of 2 µm. The resultant stent demonstrates almost 100% endothelialization at 30 days in preclinical model and zero percent MACE >18 months in the primary efficacy and safety clinical study.

  4. Transarterial chemoembolization with drug-eluting beads for hepatocellular carcinoma: its research progress

    International Nuclear Information System (INIS)

    Zhao Yan; Han Guohong; Bai Wei; Fan Daiming

    2012-01-01

    Transarterial chemoembolization (TACE) has been the main treatment for patients with intermediate-stage hepatocellular carcinoma (HCC). However, the clinical application of TACE is limited due to the technical deficiencies, such as uncontrolled local drug delivery and systemic toxicity. Recently, the new drug-eluting beads (DEB), loading with doxorubicin, have be used in the TACE procedures. This new technique can not only maintain the local drug level for quite a long time and thus get a higher objective response, but also decrease the systemic toxicity. Transarterial chemoembolization with drug-eluting beads (DEB-TACE) have already been widely used abroad, and more related clinical trials are underway to clarify its advantages. This paper aims to make a comprehensive review in the respects of its characteristics and the latest research progress in DEB-TACE. (authors)

  5. Influence of characteristics of time series on short-term forecasting error parameter changes in real time

    Science.gov (United States)

    Klevtsov, S. I.

    2018-05-01

    The impact of physical factors, such as temperature and others, leads to a change in the parameters of the technical object. Monitoring the change of parameters is necessary to prevent a dangerous situation. The control is carried out in real time. To predict the change in the parameter, a time series is used in this paper. Forecasting allows one to determine the possibility of a dangerous change in a parameter before the moment when this change occurs. The control system in this case has more time to prevent a dangerous situation. A simple time series was chosen. In this case, the algorithm is simple. The algorithm is executed in the microprocessor module in the background. The efficiency of using the time series is affected by its characteristics, which must be adjusted. In the work, the influence of these characteristics on the error of prediction of the controlled parameter was studied. This takes into account the behavior of the parameter. The values of the forecast lag are determined. The results of the research, in the case of their use, will improve the efficiency of monitoring the technical object during its operation.

  6. Time-resolved measurement of the quantum states of photons using two-photon interference with short-time reference pulses

    International Nuclear Information System (INIS)

    Ren Changliang; Hofmann, Holger F.

    2011-01-01

    To fully utilize the energy-time degree of freedom of photons for optical quantum-information processes, it is necessary to control and characterize the temporal quantum states of the photons at extremely short time scales. For measurements of the temporal coherence of the quantum states beyond the time resolution of available detectors, two-photon interference with a photon in a short-time reference pulse may be a viable alternative. In this paper, we derive the temporal measurement operators for the bunching statistics of a single-photon input state with a photon from a weak coherent reference pulse. It is shown that the effects of the pulse shape of the reference pulse can be expressed in terms of a spectral filter selecting the bandwidth within which the measurement can be treated as an ideal projection on eigenstates of time. For full quantum tomography, temporal coherence can be determined by using superpositions of reference pulses at two different times. Moreover, energy-time entanglement can be evaluated based on the two-by-two entanglement observed in the coherences between pairs of detection times.

  7. Efficacy and safety of zotarolimus-eluting and sirolimus-eluting coronary stents in routine clinical care (SORT OUT III): a randomised controlled superiority trial

    DEFF Research Database (Denmark)

    Rasmussen, Klaus; Maeng, Michael; Kaltoft, Anne

    2010-01-01

    In low-risk patients, the zotarolimus-eluting stent has been shown to reduce rates of restenosis without increasing the risk of stent thrombosis. We compared the efficacy and safety of the zotarolimus-eluting stent versus the sirolimus-eluting stent in patients with coronary artery disease who we...

  8. Characterization of new eye drops with choline salicylate and assessment of their irritancy by in vitro short time exposure tests.

    Science.gov (United States)

    Wroblewska, Katarzyna; Kucinska, Małgorzata; Murias, Marek; Lulek, Janina

    2015-09-01

    The aim of our study was to examine the irritation potential of new eye drops containing 2% choline salicylate (CS) as an active pharmaceutical ingredient (API) and various polymers increasing eye drop viscosity (hydroxyethylcellulose, hydroxypropyl methylcellulose, methylcellulose, polyvinyl alcohol, polyvinylpyrrolidone). The standard method for assessing the potential of irritating substances has been the Draize rabbit eye test. However the European Centre for Validation of Alternative Methods and the Coordinating Committee for Validation of Alternative Methods recommend, short time exposure (STE) in vitro tests as an alternative method for assessing eye irritation. The eye irritation potential was determined using cytotoxicity test methods for rabbit corneal cell line (SIRC) after 5 min exposure. The viability of cells was determined using two cytotoxicity assays: MTT and Neutral Red Uptake. According to the irritation rankings for the short time exposure test, all tested eye drops are classified as non-irritating (cell viability >70%).

  9. High-Temperature Short-Time Pasteurization System for Donor Milk in a Human Milk Bank Setting

    OpenAIRE

    Diana Escuder-Vieco; Irene Espinosa-Martos; Juan M. Rodríguez; Nieves Corzo; Antonia Montilla; Pablo Siegfried; Carmen R. Pallás-Alonso; Carmen R. Pallás-Alonso; Leónides Fernández

    2018-01-01

    Donor milk is the best alternative for the feeding of preterm newborns when mother's own milk is unavailable. For safety reasons, it is usually pasteurized by the Holder method (62.5°C for 30 min). Holder pasteurization results in a microbiological safe product but impairs the activity of many biologically active compounds such as immunoglobulins, enzymes, cytokines, growth factors, hormones or oxidative stress markers. High-temperature short-time (HTST) pasteurization has been proposed as an...

  10. Testing of Commercial Milk Production Technology Using A Combination of High Temperature Short Time and Pulsed Electric Field

    OpenAIRE

    Hadi A; Widjanarko SB; Kusnadi J

    2016-01-01

    The development of milk processing technology has grown excessively, and it contains advantage and disadvantage. This study used mixed between PEF (Pulsed Electric Field) and High Temperature Short Time (HTST) to produce milk processed product which is effective and efficient in killing milk microorganism without changing its color, scent, and nutrient content of processed product, therefore producing commercial sterile milk product in accord with milk Indonesian National Standard (SNI). The ...

  11. Experience from the transportation of irradiated WWER-440 fuel assemblies at the Kozloduy NPP site after a short cooling time

    International Nuclear Information System (INIS)

    Stoyanova, I.; Kamenov, A.; Byrzev, L.; Christoskov, I.

    2003-01-01

    Results from the analysis and experimental verification of the radiation and shielding characteristics of non-standard loading patterns of the VSPOT transport cask used for transportation of irradiated fuel assemblies after a short cooling time (120 180 days) on the site of the Kozloduy NPP are presented. An additional safety criterion related to the introduced modifications to the standard procedure of using the transport cask is formulated and discussed (Authors)

  12. On the applicability of short time measurements to the determination of annual average of radon concentration in dwelling

    International Nuclear Information System (INIS)

    Loskiewicz, J.; Olko, P.; Swakon, J.; Bogacz, J.; Janik, M.; Mazur, D.; Mazur, J.

    1998-01-01

    The variation of radon concentration in some houses in the Krakow region was investigated in order to compare results obtained using various measuring techniques. It is concluded that short-term measurements should last at least 4 days to avoid errors exceeding 30%; that weather parameters and human activity during the measurement should be recorded; that measurements should be repeated several times under various weather conditions; that seasonal variation in the region should be taken into account. (A.K.)

  13. Histologic Assessment of Drug-Eluting Grafts Related to Implantation Site

    Directory of Open Access Journals (Sweden)

    Jean-Christophe Tille

    2016-02-01

    Full Text Available Drug-eluting vascular prostheses represent a new direction in vascular surgery to reduce early thrombosis and late intimal hyperplasia for small calibre grafts. Subcutaneous implantation in rats is a rapid and cost-effective screening model to assess the drug-elution effect and could, to some extent, be useful to forecast results for vascular prostheses. We compared biological and histological responses to scaffolds in different implantation sites. Polycaprolactone (PCL, paclitaxel-loaded PCL (PCL-PTX and dexamethasone-loaded PCL (PCL-DXM electrospun scaffolds were implanted subcutaneously and in an infrarenal abdominal aortic model in rats for up to 12 weeks. At the conclusion of the study, a histological analysis was performed. Cellular graft invasion revealed differences in the progression of cellular infiltration between PCL-PTX and PCL/PCL-DXM groups in both models. Cell infiltration increased over time in the aortic model compared to the subcutaneous model for all groups. Cell counting revealed major differences in fibroblast, macrophage and giant cell graft colonisation in all groups and models over time. Macrophages and giant cells increased in the PCL aortic model; whereas in the subcutaneous model these cell types increased only after three weeks or even decreased in the drug-eluting PCL groups. Other major findings were observed only in the aortic replacement such as extracellular matrix deposition and neo-angiogenesis. The subcutaneous implant model can be used for screening, especially when drug-eluting effects are studied. However, major histological differences were observed in cell type reaction and depth of cell penetration compared to the aortic model. Our results demonstrate that the implantation site is a critical determinant of the biological response.

  14. Use of cadmium sulphide to measure integrated dose in short-time irradiation

    International Nuclear Information System (INIS)

    Nimnual, S.

    1975-01-01

    An experiment was made to measure the dose from a short burst of X-rays in the order of 1 second or less by means of the cadmium sulphide photoconductive cell. If protected from light, the CdS cell has a very high resistance such that it does not discharge a capacitor appreciably. But during irradiation, the resistance decreases temporarily and an amount of charge will leak from the capacitor through the Ca S cell. The result to this experiment shows that the principle works very well but it is necessary to add another fixed high resistance of about 10 7 ohms into the circuit in order to get results independent of the dose-rate. The equipment used in this experiment can measure a dose as low as 6 m R

  15. High-Temperature-Short-Time Annealing Process for High-Performance Large-Area Perovskite Solar Cells.

    Science.gov (United States)

    Kim, Minjin; Kim, Gi-Hwan; Oh, Kyoung Suk; Jo, Yimhyun; Yoon, Hyun; Kim, Ka-Hyun; Lee, Heon; Kim, Jin Young; Kim, Dong Suk

    2017-06-27

    Organic-inorganic hybrid metal halide perovskite solar cells (PSCs) are attracting tremendous research interest due to their high solar-to-electric power conversion efficiency with a high possibility of cost-effective fabrication and certified power conversion efficiency now exceeding 22%. Although many effective methods for their application have been developed over the past decade, their practical transition to large-size devices has been restricted by difficulties in achieving high performance. Here we report on the development of a simple and cost-effective production method with high-temperature and short-time annealing processing to obtain uniform, smooth, and large-size grain domains of perovskite films over large areas. With high-temperature short-time annealing at 400 °C for 4 s, the perovskite film with an average domain size of 1 μm was obtained, which resulted in fast solvent evaporation. Solar cells fabricated using this processing technique had a maximum power conversion efficiency exceeding 20% over a 0.1 cm 2 active area and 18% over a 1 cm 2 active area. We believe our approach will enable the realization of highly efficient large-area PCSs for practical development with a very simple and short-time procedure. This simple method should lead the field toward the fabrication of uniform large-scale perovskite films, which are necessary for the production of high-efficiency solar cells that may also be applicable to several other material systems for more widespread practical deployment.

  16. Nonlinear detection of disordered voice productions from short time series based on a Volterra-Wiener-Korenberg model

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Yu, E-mail: yuzhang@xmu.edu.cn [Key Laboratory of Underwater Acoustic Communication and Marine Information Technology of the Ministry of Education, Xiamen University, Xiamen Fujian 361005 (China); Sprecher, Alicia J. [Department of Surgery, Division of Otolaryngology - Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792-7375 (United States); Zhao Zongxi [Key Laboratory of Underwater Acoustic Communication and Marine Information Technology of the Ministry of Education, Xiamen University, Xiamen Fujian 361005 (China); Jiang, Jack J. [Department of Surgery, Division of Otolaryngology - Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792-7375 (United States)

    2011-09-15

    Highlights: > The VWK method effectively detects the nonlinearity of a discrete map. > The method describes the chaotic time series of a biomechanical vocal fold model. > Nonlinearity in laryngeal pathology is detected from short and noisy time series. - Abstract: In this paper, we apply the Volterra-Wiener-Korenberg (VWK) model method to detect nonlinearity in disordered voice productions. The VWK method effectively describes the nonlinearity of a third-order nonlinear map. It allows for the analysis of short and noisy data sets. The extracted VWK model parameters show an agreement with the original nonlinear map parameters. Furthermore, the VWK mode method is applied to successfully assess the nonlinearity of a biomechanical voice production model simulating irregular vibratory dynamics of vocal folds with a unilateral vocal polyp. Finally, we show the clinical applicability of this nonlinear detection method to analyze the electroglottographic data generated by 14 patients with vocal nodules or polyps. The VWK model method shows potential in describing the nonlinearity inherent in disordered voice productions from short and noisy time series that are common in the clinical setting.

  17. Nonlinear detection of disordered voice productions from short time series based on a Volterra-Wiener-Korenberg model

    International Nuclear Information System (INIS)

    Zhang Yu; Sprecher, Alicia J.; Zhao Zongxi; Jiang, Jack J.

    2011-01-01

    Highlights: → The VWK method effectively detects the nonlinearity of a discrete map. → The method describes the chaotic time series of a biomechanical vocal fold model. → Nonlinearity in laryngeal pathology is detected from short and noisy time series. - Abstract: In this paper, we apply the Volterra-Wiener-Korenberg (VWK) model method to detect nonlinearity in disordered voice productions. The VWK method effectively describes the nonlinearity of a third-order nonlinear map. It allows for the analysis of short and noisy data sets. The extracted VWK model parameters show an agreement with the original nonlinear map parameters. Furthermore, the VWK mode method is applied to successfully assess the nonlinearity of a biomechanical voice production model simulating irregular vibratory dynamics of vocal folds with a unilateral vocal polyp. Finally, we show the clinical applicability of this nonlinear detection method to analyze the electroglottographic data generated by 14 patients with vocal nodules or polyps. The VWK model method shows potential in describing the nonlinearity inherent in disordered voice productions from short and noisy time series that are common in the clinical setting.

  18. Effects of light guide and magnetic field on the characteristics of the short time measuring system

    International Nuclear Information System (INIS)

    Yamada, Yoshihiro; Ohira, Kyozo

    1977-01-01

    In order to construct the nuclear life-time measurement apparatus with good energy and time resolution, consisting of DuMond type beta-ray spectrometer and plastic scintillator, experimental studies are carried out for the effects of light guide and magnetic field on the time resolution, and for the effects of μ-metal shielding on the energy resolution. It has been found that all these effects could be practically diminished. (auth.)

  19. Short-Term Bus Passenger Demand Prediction Based on Time Series Model and Interactive Multiple Model Approach

    Directory of Open Access Journals (Sweden)

    Rui Xue

    2015-01-01

    Full Text Available Although bus passenger demand prediction has attracted increased attention during recent years, limited research has been conducted in the context of short-term passenger demand forecasting. This paper proposes an interactive multiple model (IMM filter algorithm-based model to predict short-term passenger demand. After aggregated in 15 min interval, passenger demand data collected from a busy bus route over four months were used to generate time series. Considering that passenger demand exhibits various characteristics in different time scales, three time series were developed, named weekly, daily, and 15 min time series. After the correlation, periodicity, and stationarity analyses, time series models were constructed. Particularly, the heteroscedasticity of time series was explored to achieve better prediction performance. Finally, IMM filter algorithm was applied to combine individual forecasting models with dynamically predicted passenger demand for next interval. Different error indices were adopted for the analyses of individual and hybrid models. The performance comparison indicates that hybrid model forecasts are superior to individual ones in accuracy. Findings of this study are of theoretical and practical significance in bus scheduling.

  20. Time does not cause forgetting in short-term serial recall.

    Science.gov (United States)

    Lewandowsky, Stephan; Duncan, Matthew; Brown, Gordon D A

    2004-10-01

    Time-based theories expect memory performance to decline as the delay between study and recall of an item increases. The assumption of time-based forgetting, central to many models of serial recall, underpins their key behaviors. Here we compare the predictions of time-based and event-based models by simulation and test them in two experiments using a novel manipulation of the delay between study and retrieval. Participants were trained, via corrective feedback, to recall at different speeds, thus varying total recall time from 6 to 10 sec. In the first experiment, participants used the keyboard to enter their responses but had to repeat a word (called the suppressor) aloud during recall to prevent rehearsal. In the second experiment, articulation was again required, but recall was verbal and was paced by the number of repetitions of the suppressor in between retrieval of items. In both experiments, serial position curves for all retrieval speeds overlapped, and output time had little or no effect. Comparative evaluation of a time-based and an event-based model confirmed that these results present a particular challenge to time-based approaches. We conclude that output interference, rather than output time, is critical in serial recall.

  1. Estimation of train dwell time at short stops based on track occupation event data

    NARCIS (Netherlands)

    Li, D.; Daamen, W.; Goverde, R.M.P.

    2015-01-01

    Train dwell time is one of the most unpredictable components of railway operations mainly due to the varying volumes of alighting and boarding passengers. For reliable estimations of train running times and route conflicts on main lines it is however necessary to obtain accurate estimations of dwell

  2. FALSE DETERMINATIONS OF CHAOS IN SHORT NOISY TIME SERIES. (R828745)

    Science.gov (United States)

    A method (NEMG) proposed in 1992 for diagnosing chaos in noisy time series with 50 or fewer observations entails fitting the time series with an empirical function which predicts an observation in the series from previous observations, and then estimating the rate of divergenc...

  3. Development of a New Class of Scintillating Fibres with Very Short Decay Time and High Light Yield

    International Nuclear Information System (INIS)

    Borshchev, O.; Ponomarenko, S.; Surin, N.; Cavalcante, A.B.R.; Gavardi, L.; Gruber, L.; Joram, C.; Shinji, O.

    2017-01-01

    We present first studies of a new class of scintillating fibres which are characterised by very short decay times and high light yield. The fibres are based on a novel type of luminophores admixed to a polystyrene core matrix. These so-called Nanostructured Organosilicon Luminophores (NOL) have high photoluminescense quantum yield and decay times just above 1 ns. A blue and a green emitting prototype fibre with 250 μm diameter were produced and characterised in terms of attenuation length, ionisation light yield, decay time and tolerance to x-ray irradiation. The well-established Kuraray SCSF-78 and SCSF-3HF fibres were taken as references. Even though the two prototype fibres mark just an intermediate step in an ongoing development, their performance is already on a competitive level. In particular, their decay time constants are about a factor of two shorter than the fastest known fibres, which makes them promising candidates for time critical applications.

  4. Everolimus-eluting bioresorbable stent vs. durable polymer everolimus-eluting metallic stent in patients with ST-segment elevation myocardial infarction

    DEFF Research Database (Denmark)

    Sabaté, Manel; Windecker, Stephan; Iñiguez, Andres

    2015-01-01

    AIMS: Patients with ST-segment elevation myocardial infarction (STEMI) feature thrombus-rich lesions with large necrotic core, which are usually associated with delayed arterial healing and impaired stent-related outcomes. The use of bioresorbable vascular scaffolds (Absorb) has the potential...... to overcome these limitations owing to restoration of native vessel lumen and physiology at long term. The purpose of this randomized trial was to compare the arterial healing response at short term, as a surrogate for safety and efficacy, between the Absorb and the metallic everolimus-eluting stent (EES...... was the 6-month optical frequency domain imaging healing score (HS) based on the presence of uncovered and/or malapposed stent struts and intraluminal filling defects. Main secondary endpoint included the device-oriented composite endpoint (DOCE) according to the Academic Research Consortium definition...

  5. VCSELs in short-pulse operation for time-of-flight applications

    Science.gov (United States)

    Moench, Holger; Gronenborn, Stephan; Gu, Xi; Gudde, Ralph; Herper, Markus; Kolb, Johanna; Miller, Michael; Smeets, Michael; Weigl, Alexander

    2018-02-01

    VCSEL arrays are the ideal light source for 3D imaging applications. The narrow emission spectrum and the ability for short pulses make them superior to LEDs. Combined with fast photodiodes or special camera chips spatial information can be obtained which is needed in diverse applications like camera autofocus, indoor navigation, 3D-object recognition, augmented reality or autonomously driving vehicles. Pulse operation at the ns scale and at low duty cycle can work with significantly higher current than traditionally used for VCSELs in continuous wave operation. With reduced thermal limitations at low average heat dissipation very high currents become feasible and tens of Watts output power have been realized with small VCSEL chips. The optical emission pattern of VCSELs can be tailored to the desired field of view using beam shaping elements. Such optical elements also enable laser safe class 1 products. A detailed analysis of the complete system and the operation mode is required to calculate the maximum permitted power for a safe system. The good VCSEL properties like robustness, stability over temperature and the potential for integrated solutions open a huge potential for VCSELs in new mass applications in the consumer and automotive markets.

  6. Short- and long-term effects of real-time medication monitoring with short message service (SMS) reminders for missed doses on the refill adherence of people with Type 2 diabetes: evidence from a randomised controlled trial.

    NARCIS (Netherlands)

    Vervloet, M.; Dijk, L. van; Bakker, D.H. de; Souverein, P.C.; Santen-Reestman, J.; Vlijmen, B. van; Aarle, M.C.W. van; Hoek, L.S. van der; Bouvy, M.L.

    2014-01-01

    Aims: To investigate short- and long-term effects of real-time monitoring medication use combined with short message service (SMS) reminders for missed doses on refill adherence to oral anti-diabetic medication. Methods: A randomized controlled trial with two intervention groups and one control

  7. Incorporating geostrophic wind information for improved space–time short-term wind speed forecasting

    KAUST Repository

    Zhu, Xinxin; Bowman, Kenneth P.; Genton, Marc G.

    2014-01-01

    pressure, temperature, and other meteorological variables, no improvement in forecasting accuracy was found by incorporating air pressure and temperature directly into an advanced space-time statistical forecasting model, the trigonometric direction diurnal

  8. The elution of certain protein affinity tags with millimolar concentrations of diclofenac.

    Science.gov (United States)

    Baliova, Martina; Juhasova, Anna; Jursky, Frantisek

    2015-12-01

    Diclofenac (2-[(2, 6-dichlorophenyl)amino] benzeneacetic acid) is a sparingly soluble, nonsteroidal anti-inflammatory drug therapeutically acting at low micromolar concentrations. In pH range from 8 to 11, its aqueous solubility can be increased up to 200 times by the presence of counter ions such as sodium. Our protein interaction studies revealed that a millimolar concentration of sodium diclofenac is able to elute glutathione S-transferase (GST), cellulose binding protein (CBD), and maltose binding protein (MBP) but not histidine-tagged or PDZ-tagged proteins from their affinity resins. The elution efficiency of diclofenac is comparable with the eluting agents normally used at similar concentrations. Native gel electrophoresis of sodium diclofenac-treated proteins showed that the interaction is non-covalent and non-denaturing. These results suggest that sodium diclofenac, in addition to its pharmaceutical applications, can also be exploited as a lead for the development of new proteomics reagents. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. The impact of short prehospital times on trauma center performance benchmarking: An ecologic study.

    Science.gov (United States)

    Byrne, James P; Mann, N Clay; Hoeft, Christopher J; Buick, Jason; Karanicolas, Paul; Rizoli, Sandro; Hunt, John P; Nathens, Avery B

    2016-04-01

    Emergency medical service (EMS) prehospital times vary between regions, yet the impact of local prehospital times on trauma center (TC) performance is unknown. To inform external benchmarking efforts, we explored the impact of EMS prehospital times on the risk-adjusted rate of emergency department (ED) death and overall hospital mortality at urban TCs across the United States. We used a novel ecologic study design, linking EMS data from the National EMS Information System to TCs participating in the American College of Surgeons' Trauma Quality Improvement Program (TQIP) by destination zip code. This approach provided EMS times for populations of injured patients transported to TQIP centers. We defined the exposure of interest as the 90th percentile total prehospital time (PHT) for each TC. TCs were then stratified by PHT quartile. Analyses were limited to adult patients with severe blunt or penetrating trauma, transported directly by land to urban TQIP centers. Random-intercept multilevel modeling was used to evaluate the risk-adjusted relationship between PHT quartile and the outcomes of ED death and overall hospital mortality. During the study period, 119,740 patients met inclusion criteria at 113 TCs. ED death occurred in 1% of patients, and overall mortality was 7.2%. Across all centers, the median PHT was 61 minutes (interquartile range, 53-71 minutes). After risk adjustment, TCs in regions with the shortest quartile of PHTs (<53 minutes) had significantly greater odds of ED death compared with those with the longest PHTs (odds ratio, 2.00; 95% confidence interval, 1.43-2.78). However, there was no association between PHT and overall TC mortality. At urban TCs, local EMS prehospital times are a significant predictor of ED death. However, no relationship exists between prehospital time and overall TC risk-adjusted mortality. Therefore, there is no evidence for the inclusion of EMS prehospital time in external benchmarking analyses.

  10. Short-Term Wave Forecasting for Real-Time Control of Wave Energy Converters

    OpenAIRE

    Fusco, Francesco; Ringwood, John

    2010-01-01

    Real-time control of wave energy converters requires knowledge of future incident wave elevation in order to approach optimal efficiency of wave energy extraction. We present an approach where the wave elevation is treated as a time series and it is predicted only from its past history. A comparison of a range of forecasting methodologies on real wave observations from two different locations shows how the relatively simple linear autoregressive model, which implicitly models the cyclical beh...

  11. RubiShort: Reducing scan time in 82Rb heart scans to minimize movements artifacts

    DEFF Research Database (Denmark)

    Madsen, Jeppe; Vraa, Kaspar J.; Harms, Hans

    .013x, R2=0.98; %Reversible: y=1.008x, R2=0.95; TPD: y=1.000x, R2=0.99). Conclusion:, Scan time of myocardial perfusion scans using 82Rb can be reduced from 7 min. to 5 min. without loss of quantitative accuracy. Since patient motion is frequent in the last minutes of the scans, scan time reduction...

  12. Dead-time corrections on long-interval measurements of short-lived activities

    International Nuclear Information System (INIS)

    Irfan, M.

    1977-01-01

    A method has been proposed to make correction for counting losses due to dead time where the counting interval is comparable to or larger than the half-life of the activity under investigation. Counts due to background and any long-lived activity present in the source have been taken into consideration. The method is, under certain circumstances, capable of providing a valuable check on the accuracy of the dead time of the counting system. (Auth.)

  13. Local perivascular delivery of anti-restenotic agents from a drug-eluting poly(ε-caprolactone) stent cuff

    NARCIS (Netherlands)

    Pires, N.M.M.; Hoeven, B.L. van der; Vries, M.R. de; Havekes, L.M.; Vlijmen, B.J. van; Hennink, W.E.; Quax, P.H.A.; Jukema, J.W.

    2005-01-01

    The introduction of drug-eluting stents (DES) to prevent in-stent restenosis is one of the major advances in interventional cardiology. Currently many types of DES are under evaluation for effectiveness and safety, a time-consuming and difficult procedure in humans. An animal model that allows rapid

  14. Association between prehospital time interval and short-term outcome in acute heart failure patients.

    Science.gov (United States)

    Takahashi, Masashi; Kohsaka, Shun; Miyata, Hiroaki; Yoshikawa, Tsutomu; Takagi, Atsutoshi; Harada, Kazumasa; Miyamoto, Takamichi; Sakai, Tetsuo; Nagao, Ken; Sato, Naoki; Takayama, Morimasa

    2011-09-01

    Acute heart failure (AHF) is one of the most frequently encountered cardiovascular conditions that can seriously affect the patient's prognosis. However, the importance of early triage and treatment initiation in the setting of AHF has not been recognized. The Tokyo Cardiac Care Unit Network Database prospectively collected information of emergency admissions to acute cardiac care facilities in 2005-2007 from 67 participating hospitals in the Tokyo metropolitan area. We analyzed records of 1,218 AHF patients transported to medical centers via emergency medical services (EMS). AHF was defined as rapid onset or change in the signs and symptoms of heart failure, resulting in the need for urgent therapy. Patients with acute coronary syndrome were excluded from this analysis. Logistic regression analysis was performed to calculate the risk-adjusted in-hospital mortality. A majority of the patients were elderly (76.1 ± 11.5 years old) and male (54.1%). The overall in-hospital mortality rate was 6.0%. The median time interval between symptom onset and EMS arrival (response time) was 64 minutes (interquartile range [IQR] 26-205 minutes), and that between EMS arrival and ER arrival (transportation time) was 27 minutes (IQR 9-78 minutes). The risk-adjusted mortality increased with transportation time, but did not correlate with the response time. Those who took >45 minutes to arrive at the medical centers were at a higher risk for in-hospital mortality (odds ratio 2.24, 95% confidence interval 1.17-4.31; P = .015). Transportation time correlated with risk-adjusted mortality, and steps should be taken to reduce the EMS transfer time to improve the outcome in AHF patients. Copyright © 2011 Elsevier Inc. All rights reserved.

  15. Geometric patterns of time-delay plots from different cardiac rhythms and arrhythmias using short-term EKG signals.

    Science.gov (United States)

    Borracci, Raúl A; Montoya Pulvet, José D; Ingino, Carlos A; Fitz Maurice, Mario; Hirschon Prado, Alfredo; Dominé, Enrique

    2017-12-27

    To date, no systematic work has been intended to describe spatio-temporal patterns of cardiac rhythms using only short series of RR intervals, to facilitate visual or computerized-aided identification of EKG motifs for use in clinical practice. The aim of this study was to detect and classify eye-catching geometric patterns of Poincaré time-delay plots from different types of cardiac rhythms and arrhythmias using short-term EKG signals. Approximately 150-300 representative, consecutive beats were retrieved from 24-h Holter registers of 100 patients with different heart rhythms. Two-dimensional Poincaré charts were created, and the resulting geometric patterns were transformed into representative familiar eye-catching drawings to interpret different arrhythmias. Poincaré plot representation of RR interval data revealed a wide variety of visual patterns: (i) comet-shaped for sinus rhythm; (ii) torpedo-shaped for sinus bradycardia; (iii) cigarette-shaped for sinus tachycardia; (iv) butterfly-shaped for sinus tachycardia and isolated atrial premature complexes; (v) arrow-shaped for isolated premature complexes and inappropriate sinus tachycardia; (vi) inverted fan-shaped for sinus rhythm with frequent atrial premature complexes; (vii) tornado-shaped for atrial flutter and atrial tachycardia; and (viii) fan-shaped for atrial fibrillation. Modified Poincaré plots with smoothed lines connecting successive points could accurately classify different types of arrhythmias based on short RR interval sequence variability. Characteristic emergent patterns can be visually identified and eventually could be distinguished by an automatic classification system able to discern between arrhythmias. This work provides an alternative method to interpret time-delay plots obtained from short-term EKG signal recordings. © 2017 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.

  16. Femtosecond timing-jitter between photo-cathode laser and ultra-short electron bunches by means of hybrid compression

    CERN Document Server

    Pompili, Riccardo; Bellaveglia, M; Biagioni, A; Castorina, G; Chiadroni, E; Cianchi, A; Croia, M; Di Giovenale, D; Ferrario, M; Filippi, F; Gallo, A; Gatti, G; Giorgianni, F; Giribono, A; Li, W; Lupi, S; Mostacci, A; Petrarca, M; Piersanti, L; Di Pirro, G; Romeo, S; Scifo, J; Shpakov, V; Vaccarezza, C; Villa, F

    2017-01-01

    The generation of ultra-short electron bunches with ultra-low timing-jitter relative to the photo-cathode (PC) laser has been experimentally proved for the first time at the SPARC_LAB test-facility (INFN-LNF, Frascati) exploiting a two-stage hybrid compression scheme. The first stage employs RF-based compression (velocity-bunching), which shortens the bunch and imprints an energy chirp on it. The second stage is performed in a non-isochronous dogleg line, where the compression is completed resulting in a final bunch duration below 90 fs (rms). At the same time, the beam arrival timing-jitter with respect to the PC laser has been measured to be lower than 20 fs (rms). The reported results have been validated with numerical simulations.

  17. Femtosecond timing-jitter between photo-cathode laser and ultra-short electron bunches by means of hybrid compression

    International Nuclear Information System (INIS)

    Pompili, R; Anania, M P; Bellaveglia, M; Biagioni, A; Castorina, G; Chiadroni, E; Croia, M; Giovenale, D Di; Ferrario, M; Gallo, A; Gatti, G; Cianchi, A; Filippi, F; Giorgianni, F; Giribono, A; Lupi, S; Mostacci, A; Petrarca, M; Piersanti, L; Li, W

    2016-01-01

    The generation of ultra-short electron bunches with ultra-low timing-jitter relative to the photo-cathode (PC) laser has been experimentally proved for the first time at the SPARC-LAB test-facility (INFN-LNF, Frascati) exploiting a two-stage hybrid compression scheme. The first stage employs RF-based compression (velocity-bunching), which shortens the bunch and imprints an energy chirp on it. The second stage is performed in a non-isochronous dogleg line, where the compression is completed resulting in a final bunch duration below 90 fs (rms). At the same time, the beam arrival timing-jitter with respect to the PC laser has been measured to be lower than 20 fs (rms). The reported results have been validated with numerical simulations. (paper)

  18. Markov Chain Modelling for Short-Term NDVI Time Series Forecasting

    Directory of Open Access Journals (Sweden)

    Stepčenko Artūrs

    2016-12-01

    Full Text Available In this paper, the NDVI time series forecasting model has been developed based on the use of discrete time, continuous state Markov chain of suitable order. The normalised difference vegetation index (NDVI is an indicator that describes the amount of chlorophyll (the green mass and shows the relative density and health of vegetation; therefore, it is an important variable for vegetation forecasting. A Markov chain is a stochastic process that consists of a state space. This stochastic process undergoes transitions from one state to another in the state space with some probabilities. A Markov chain forecast model is flexible in accommodating various forecast assumptions and structures. The present paper discusses the considerations and techniques in building a Markov chain forecast model at each step. Continuous state Markov chain model is analytically described. Finally, the application of the proposed Markov chain model is illustrated with reference to a set of NDVI time series data.

  19. Efficacy and cytotoxicity of a bleaching gel after short application times on dental enamel.

    Science.gov (United States)

    Soares, Diana Gabriela; Ribeiro, Ana Paula Dias; da Silveira Vargas, Fernanda; Hebling, Josimeri; de Souza Costa, Carlos Alberto

    2013-11-01

    This study aimed to evaluate and correlate the efficacy and cytotoxicity of a 35 % hydrogen peroxide (HP) bleaching gel after different application times on dental enamel. Enamel/dentin disks in artificial pulp chambers were placed in wells containing culture medium. The following groups were formed: G1, control (no bleaching); G2 and G3, three or one 15-min bleaching applications, respectively; and G4 and G5, three or one 5-min bleaching applications, respectively. Extracts (culture medium with bleaching gel components) were applied for 60 min on cultured odontoblast-like MDPC-23 cells. Cell metabolism (methyl tetrazolium assay) (Kruskal-Wallis/Mann-Whitney; α = 5 %) and cell morphology (scanning electron microscopy) were analyzed immediately after the bleaching procedures and the trans-enamel and trans-dentinal HP diffusion quantified (one-way analysis of variance/Tukey's test; α = 5 %). The alkaline phosphatase (ALP) activity was evaluated 24 h after the contact time of the extracts with the cells (Kruskal-Wallis/Mann-Whitney; α = 5 %). Tooth color was analyzed before and 24 h after bleaching using a spectrophotometer according to the Commission Internationale de l'Eclairage L*a*b* system (Kruskal-Wallis/Mann-Whitney; α = 0.05). Significant difference (p 0.05). The lowest amount of HP diffusion was observed in G5 (p 0.05). HP diffusion through dental tissues and its cytotoxic effects were proportional to the contact time of the bleaching gel with enamel. However, shorter bleaching times reduced bleaching efficacy. Shortening the in-office tooth bleaching time could be an alternative to minimize the cytotoxic effects of this clinical procedure to pulp tissue. However, the reduced time of bleaching agent application on enamel may not provide adequate esthetic outcome.

  20. An evaluation of the optimum timing for planting short rotation coppice

    Energy Technology Data Exchange (ETDEWEB)

    Turnbull, D.J.; Jefferies, R.; Parfitt, R.

    2004-07-01

    This report summarises the results of a project to determine the optimum timing for planting, evaluate problems due to late planting in the spring, and to study the planting of willows at different times during the autumn. Details are given of the site installation, previous research on the effect of planting date and storage, and assessment of the establishment and biomass productivity and the viability of cuttings in long-term storage. Charts illustrating biomass productivity are presented, and long-term storage of willow cuttings for autumn planting is discussed.

  1. Economic incentives of short out-of-reactor time for fast breeder reactor fuel

    International Nuclear Information System (INIS)

    Bentley, B.W.; Haffner, D.R.

    1975-01-01

    Economic benefits (primarily reduced uranium ore and enrichment expenditures) can be realized by reducing the LMFBR out-of-reactor fuel cycle time only if process cost penalties and R and D costs can be minimized. The results of the evaluation presented show the potential gross benefits of reducing the out-of-reactor time and the effects of various associated cost penalties on these benefits. The gross benefit results estimate the potential savings in electrical power generation in the next 50 years using constant 1975 dollars and discounting the costs at 7 1 / 2 percent per year

  2. Time-resolved plasma spectroscopy of thin foils heated by a relativistic-intensity short-pulse laser

    International Nuclear Information System (INIS)

    Audebert, P.; Gauthier, J.-C.; Shepherd, R.; Fournier, K.B.; Price, D.; Lee, R.W.; Springer, P.; Peyrusse, O.; Klein, L.

    2002-01-01

    Time-resolved K-shell x-ray spectra are recorded from sub-100 nm aluminum foils irradiated by 150-fs laser pulses at relativistic intensities of Iλ 2 =2x10 18 W μm 2 /cm 2 . The thermal penetration depth is greater than the foil thickness in these targets so that uniform heating takes place at constant density before hydrodynamic motion occurs. The high-contrast, high-intensity laser pulse, broad spectral band, and short time resolution utilized in this experiment permit a simplified interpretation of the dynamical evolution of the radiating matter. The observed spectrum displays two distinct phases. At early time, ≤500 fs after detecting target emission, a broad quasicontinuous spectral feature with strong satellite emission from multiply excited levels is seen. At a later time, the He-like resonance line emission is dominant. The time-integrated data is in accord with previous studies with time resolution greater than 1 ps. The early time satellite emission is shown to be a signature of an initial large area, high density, low-temperature plasma created in the foil by fast electrons accelerated by the intense radiation field in the laser spot. We conclude that, because of this early time phenomenon and contrary to previous predictions, a short, high-intensity laser pulse incident on a thin foil does not create a uniform hot and dense plasma. The heating mechanism has been studied as a function of foil thickness, laser pulse length, and intensity. In addition, the spectra are found to be in broad agreement with a hydrodynamic expansion code postprocessed by a collisional-radiative model based on superconfiguration average rates and on the unresolved transition array formalism

  3. Highly efficient indoor air purification using adsorption-enhanced-photocatalysis-based microporous TiO2 at short residence time.

    Science.gov (United States)

    Lv, Jinze; Zhu, Lizhong

    2013-01-01

    A short residence time is a key design parameter for the removal of organic pollutants in catalyst-based indoor air purification systems. In this study, we synthesized a series of TiO2 with different micropore volumes and studied their removal efficiency of indoor carbonyl pollutants at a short residence time. Our results indicated that the superior adsorption capability of TiO2 with micropores improved its performance in the photocatalytic degradation of cyclohexanone, while the photocatalytic removal of the pollutant successfully kept porous TiO2 from becoming saturated. When treated with 1 mg m(-3) cyclohexanone at a relatively humidity of 18%, the adsorption amount on microporous TiO2 was 5.4-7.9 times higher than that on P25. Removal efficiency via photocatalysis followed'the same order as the adsorption amount: TiO2-5 > TiO2-20 > TiO2-60 > TiO2-180 > P25. The advantage of microporous TiO2 over P25 became more pronounced when the residence time declined from 0.072 to 0.036 s. Moreover, as the concentration of cyclohexanone deceased from 1000 ppb to 500 ppb, removal efficiency by microporous TiO2 increased more rapidly than P25.

  4. Is the travel time of private roads too short, too long, or just right?

    NARCIS (Netherlands)

    van den Berg, V.A.C.; Verhoef, E.T.

    2012-01-01

    We consider price and service-quality setting in oligopolistic markets for congestible services, applied to the case of private roads. Previous studies show that parallel competitors set a volume/capacity ratio (and thereby a travel time or service quality) that is socially optimal if they take the

  5. Short time window for transmissibility of African swine fever virus from a contaminated environment

    DEFF Research Database (Denmark)

    Olesen, A S; Lohse, L; Boklund, A.

    2018-01-01

    pens after 3, 5 or 7 days did not develop any signs of ASFV infection and no viral DNA was detected in blood samples obtained from these pigs within the following 3 weeks. Thus, it was shown that exposure of pigs to an environment contaminated with ASFV can result in infection. However, the time window...

  6. The Estimation of Short Time Intervals as a Function of Age and Metronome Pacing.

    Science.gov (United States)

    Kline, Donald W.; And Others

    1980-01-01

    The time judgments of the older participants were significantly and systematically determined by a metronome rate. Results are consistent with the notion of increased field-dependence among older persons and suggest that their greater social conformity and their inability to ignore irrelevant stimuli might also be explicable. (Author)

  7. Short-time existence of solutions for mean-field games with congestion

    KAUST Repository

    Gomes, Diogo A.; Voskanyan, Vardan K.

    2015-01-01

    We consider time-dependent mean-field games with congestion that are given by a Hamilton–Jacobi equation coupled with a Fokker–Planck equation. These models are motivated by crowd dynamics in which agents have difficulty moving in high-density areas

  8. Comparison Groups in Short Interrupted Time-Series: An Illustration Evaluating No Child Left Behind

    Science.gov (United States)

    Wong, Manyee; Cook, Thomas D.; Steiner, Peter M.

    2009-01-01

    Interrupted time-series (ITS) are often used to assess the causal effect of a planned or even unplanned shock introduced into an on-going process. The pre-intervention slope is supposed to index the causal counterfactual, and deviations from it in mean, slope or variance are used to indicate an effect. However, a secure causal inference is only…

  9. Short-time effect of heavy metals upon microbial community activity

    International Nuclear Information System (INIS)

    Wang Fei; Yao Jun; Si Yang; Chen Huilun; Russel, Mohammad; Chen Ke; Qian Yiguang; Zaray, Gyula; Bramanti, Emilia

    2010-01-01

    Microcalorimetry was applied to assess and compare the toxic effect of heavy metals, such as As, Cu, Cd, Cr, Co, Pb and Zn, on the soil microbial activities and community. About 1.0 g soil spiked 5.0 mg glucose and 5.0 mg ammonium sulfate, the microbial activities were recorded as power-time curves, and their indices, microbial growth rate constant k, total heat evolution Q T , metabolic enthalpy ΔH met and mass specific heat rate J Q/S , were calculated. Comparing these thermodynamic parameters associated with growth yield, a general order of toxicity to the soil was found to be Cr > Pb > As > Co > Zn > Cd > Cu. When soil was exposed to heavy metals, the amount of bacteria and fungi decreased with the incubation time, and the bacterial number diminished sharply. It illustrates that fungi are more tolerant, and bacteria-fungi ratio would be altered under metal stress. To determine the status of the glucose consumed, a glucose biosensor with eggshell membrane was used to measure the remaining glucose in soil sample. Results showed that the time at which glucose was consumed completely was agreed with the microcalorimetric time to a large extent, and depended on the toxicity of heavy metals as well.

  10. Short-time effect of heavy metals upon microbial community activity.

    Science.gov (United States)

    Wang, Fei; Yao, Jun; Si, Yang; Chen, Huilun; Russel, Mohammad; Chen, Ke; Qian, Yiguang; Zaray, Gyula; Bramanti, Emilia

    2010-01-15

    Microcalorimetry was applied to assess and compare the toxic effect of heavy metals, such as As, Cu, Cd, Cr, Co, Pb and Zn, on the soil microbial activities and community. About 1.0 g soil spiked 5.0mg glucose and 5.0mg ammonium sulfate, the microbial activities were recorded as power-time curves, and their indices, microbial growth rate constant k, total heat evolution Q(T), metabolic enthalpy Delta H(met) and mass specific heat rate J(Q/S), were calculated. Comparing these thermodynamic parameters associated with growth yield, a general order of toxicity to the soil was found to be Cr>Pb>As>Co>Zn>Cd>Cu. When soil was exposed to heavy metals, the amount of bacteria and fungi decreased with the incubation time, and the bacterial number diminished sharply. It illustrates that fungi are more tolerant, and bacteria-fungi ratio would be altered under metal stress. To determine the status of the glucose consumed, a glucose biosensor with eggshell membrane was used to measure the remaining glucose in soil sample. Results showed that the time at which glucose was consumed completely was agreed with the microcalorimetric time to a large extent, and depended on the toxicity of heavy metals as well.

  11. Short-time effect of heavy metals upon microbial community activity

    Energy Technology Data Exchange (ETDEWEB)

    Wang Fei [Key Laboratory of Biogeology and Environmental Geology of Chinese Ministry of Education and Sino-Hungarian Joint Laboratory of Environmental Science and Health and School of Environmental Sciences, China University of Geosciences, 430074 Wuhan (China); Yao Jun, E-mail: yaojun@cug.edu.cn [Key Laboratory of Biogeology and Environmental Geology of Chinese Ministry of Education and Sino-Hungarian Joint Laboratory of Environmental Science and Health and School of Environmental Sciences, China University of Geosciences, 430074 Wuhan (China); Si Yang; Chen Huilun; Russel, Mohammad; Chen Ke; Qian Yiguang [Key Laboratory of Biogeology and Environmental Geology of Chinese Ministry of Education and Sino-Hungarian Joint Laboratory of Environmental Science and Health and School of Environmental Sciences, China University of Geosciences, 430074 Wuhan (China); Zaray, Gyula [Department of Chemical Technology and Environmental Chemistry, Eoetvoes University, H-1518 Budapest, P.O. Box 32 (Hungary); Bramanti, Emilia [Laboratory of Instrumental Analytical Chemistry, Institute for Chemical and Physical Processes, Area di Ricerca, Via G. Moruzzi 1, 56124 Pisa (Italy)

    2010-01-15

    Microcalorimetry was applied to assess and compare the toxic effect of heavy metals, such as As, Cu, Cd, Cr, Co, Pb and Zn, on the soil microbial activities and community. About 1.0 g soil spiked 5.0 mg glucose and 5.0 mg ammonium sulfate, the microbial activities were recorded as power-time curves, and their indices, microbial growth rate constant k, total heat evolution Q{sub T}, metabolic enthalpy {Delta}H{sub met} and mass specific heat rate J{sub Q/S}, were calculated. Comparing these thermodynamic parameters associated with growth yield, a general order of toxicity to the soil was found to be Cr > Pb > As > Co > Zn > Cd > Cu. When soil was exposed to heavy metals, the amount of bacteria and fungi decreased with the incubation time, and the bacterial number diminished sharply. It illustrates that fungi are more tolerant, and bacteria-fungi ratio would be altered under metal stress. To determine the status of the glucose consumed, a glucose biosensor with eggshell membrane was used to measure the remaining glucose in soil sample. Results showed that the time at which glucose was consumed completely was agreed with the microcalorimetric time to a large extent, and depended on the toxicity of heavy metals as well.

  12. Physiological Correlations with Short, Medium, and Long Cycling Time-Trial Performance

    Science.gov (United States)

    Borszcz, Fernando K.; Tramontin, Artur F.; de Souza, Kristopher M.; Carminatti, Lorival J.; Costa, Vitor P.

    2018-01-01

    Purpose: Several studies have demonstrated that physiological variables predict cycling endurance performance. However, it is still unclear whether the predictors will change over different performance durations. The aim of this study was to assess the correlations between physiological variables and cycling time trials with different durations.…

  13. D1.4 -- Short Report on Models That Incorporate Non-stationary Time Variant Effects

    DEFF Research Database (Denmark)

    Lostanlen, Yves; Pedersen, Troels; Steinboeck, Gerhard

    -to-indoor environments are presented. Furthermore, the impact of human activity on the time variation of the radio channel is investigated and first simulation results are presented. Movement models, which include realistic interaction between nodes, are part of current research activities....

  14. Like a hotel, but boring: users' experience with short-time community-based residential aftercare.

    Science.gov (United States)

    Roos, Eirik; Bjerkeset, Ottar; Svavarsdóttir, Margrét Hrönn; Steinsbekk, Aslak

    2017-12-16

    The discharge process from hospital to home for patients with severe mental illness (SMI) is often complex, and most are in need of tailored and coordinated community services at home. One solution is to discharge patients to inpatient short-stay community residential aftercare (CRA). The aim of this study was to explore how patients with SMI experience a stay in CRA established in a City in Central Norway. A descriptive qualitative study with individual interviews and a group interview with 13 persons. The CRA aims to improve the discharge process from hospital to independent supported living by facilitating the establishment of health and social services and preparing the patients. The philosophy is to help patients use community resources by e.g. not offering any organized in-house activities. The main question in the interviews was "How have you experienced the stay at the CRA?" The interviews were analyzed with a thematic approach using systematic text condensation. The participants experienced the stay at the CRA "Like a hotel" but also boring, due to the lack of organized in-house activities. The patients generally said they were not informed about the philosophy of the CRA before the stay. The participants had to come up with activities outside the CRA and said they got active help from the staff to do so; some experienced this as positive, whereas others wanted more organized in-house activities like they were used to from mental health hospital stays. Participants described the staff in the CRA to be helpful and forthcoming, but they did not notice the staff being active in organizing the aftercare. The stay at the CRA was experienced as different from other services, with more freedom and focus on self-care, and lack of in-house activities. This led to increased self-activity among the patients, but some wanted more in-house activities. To prepare the patients better for the stay at the CRA, more information about the philosophy is needed in the pre

  15. Three-factor models versus time series models: quantifying time-dependencies of interactions between stimuli in cell biology and psychobiology for short longitudinal data.

    Science.gov (United States)

    Frank, Till D; Kiyatkin, Anatoly; Cheong, Alex; Kholodenko, Boris N

    2017-06-01

    Signal integration determines cell fate on the cellular level, affects cognitive processes and affective responses on the behavioural level, and is likely to be involved in psychoneurobiological processes underlying mood disorders. Interactions between stimuli may subjected to time effects. Time-dependencies of interactions between stimuli typically lead to complex cell responses and complex responses on the behavioural level. We show that both three-factor models and time series models can be used to uncover such time-dependencies. However, we argue that for short longitudinal data the three factor modelling approach is more suitable. In order to illustrate both approaches, we re-analysed previously published short longitudinal data sets. We found that in human embryonic kidney 293 cells cells the interaction effect in the regulation of extracellular signal-regulated kinase (ERK) 1 signalling activation by insulin and epidermal growth factor is subjected to a time effect and dramatically decays at peak values of ERK activation. In contrast, we found that the interaction effect induced by hypoxia and tumour necrosis factor-alpha for the transcriptional activity of the human cyclo-oxygenase-2 promoter in HEK293 cells is time invariant at least in the first 12-h time window after stimulation. Furthermore, we applied the three-factor model to previously reported animal studies. In these studies, memory storage was found to be subjected to an interaction effect of the beta-adrenoceptor agonist clenbuterol and certain antagonists acting on the alpha-1-adrenoceptor / glucocorticoid-receptor system. Our model-based analysis suggests that only if the antagonist drug is administer in a critical time window, then the interaction effect is relevant. © The authors 2016. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All rights reserved.

  16. Current manufacturing processes of drug-eluting sutures.

    Science.gov (United States)

    Champeau, Mathilde; Thomassin, Jean-Michel; Tassaing, Thierry; Jérôme, Christine

    2017-11-01

    Drug-eluting sutures represent the next generation of surgical sutures since they fulfill their mechanical functions but also deliver the drug in their vicinity after implantation. These implants are produced by a variety of manufacturing processes. Drug-eluting sutures represent the next generation of surgical sutures since they fulfill their mechanical functions but also deliver the drug in their vicinity after implantation. These implants are produced by a variety of manufacturing processes. Two general approaches can be followed: (i) the ones that add the API into the material during the manufacturing process of the suture and (ii) the ones that load the API to an already manufactured suture. Areas covered: This review provides an overview of the current manufacturing processes for drug-eluting suture production and discusses their benefits and drawbacks depending on the type of drugs. The mechanical properties and the drug delivery profile of drug-eluting sutures are highlighted since these implants must fulfill both criteria. Expert opinion: For limited drug contents, melt extrusion and electrospinning are the emerging processes since the drug is added during the suture manufacture process. Advantageously, the drug release profile can be tuned by controlling the processing parameters specific to each process and the composition of the drug-containing polymer. If high drug content is targeted, the coating or grafting of a drug layer on a pre-manufactured suture allows for preservation of the tensile strength requirements of the suture.

  17. Development of a pheromone elution rate physical model

    Science.gov (United States)

    M.E. Teske; H.W. Thistle; B.L. Strom; H. Zhu

    2015-01-01

    A first principle modeling approach has been applied to available data describing the elution of semiochemicals from pheromone dispensers. These data included field data for 27 products developed by several manufacturers, including homemade devices, as well as environmental chamber data collected on three semiochemical products. The goal of this effort was to...

  18. Radionuclide inventories for short run-time space nuclear reactor systems

    International Nuclear Information System (INIS)

    Coats, R.L.

    1993-01-01

    Space Nuclear Reactor Systems, especially those used for propulsion, often have expected operation run times much shorter than those for land-based nuclear power plants. This produces substantially different radionuclide inventories to be considered in the safety analyses of space nuclear systems. This presentation describes an analysis utilizing ORIGEN2 and DKPOWER to provide comparisons among representative land-based and space systems. These comparisons enable early, conceptual considerations of safety issues and features in the preliminary design phases of operational systems, test facilities, and operations by identifying differences between the requirements for space systems and the established practice for land-based power systems. Early indications are that separation distance is much more effective as a safety measure for space nuclear systems than for power reactors because greater decay of the radionuclide activity occurs during the time to transport the inventory a given distance. In addition, the inventories of long-lived actinides are very low for space reactor systems

  19. Decreasing Postanesthesia Care Unit to Floor Transfer Times to Facilitate Short Stay Total Joint Replacements.

    Science.gov (United States)

    Sibia, Udai S; Grover, Jennifer; Turcotte, Justin J; Seanger, Michelle L; England, Kimberly A; King, Jennifer L; King, Paul J

    2018-04-01

    We describe a process for studying and improving baseline postanesthesia care unit (PACU)-to-floor transfer times after total joint replacements. Quality improvement project using lean methodology. Phase I of the investigational process involved collection of baseline data. Phase II involved developing targeted solutions to improve throughput. Phase III involved measured project sustainability. Phase I investigations revealed that patients spent an additional 62 minutes waiting in the PACU after being designated ready for transfer. Five to 16 telephone calls were needed between the PACU and the unit to facilitate each patient transfer. The most common reason for delay was unavailability of the unit nurse who was attending to another patient (58%). Phase II interventions resulted in transfer times decreasing to 13 minutes (79% reduction, P care at other institutions. Copyright © 2016 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.

  20. A short note on the mean exit time of the Brownian motion

    Science.gov (United States)

    Cadeddu, Lucio; Farina, Maria Antonietta

    We investigate the functional Ω↦ℰ(Ω) where Ω runs through the set of compact domains of fixed volume v in any Riemannian manifold (M,g) and where ℰ(Ω) is the mean exit time from Ω of the Brownian motion. We give an alternative analytical proof of a well-known fact on its critical points proved by McDonald: the critical points of ℰ(Ω) are harmonic domains.

  1. Antipersistent dynamics in short time scale variability of self-potential signals

    OpenAIRE

    Cuomo, V.; Lanfredi, M.; Lapenna, V.; Macchiato, M.; Ragosta, M.; Telesca, L.

    2000-01-01

    Time scale properties of self-potential signals are investigated through the analysis of the second order structure function (variogram), a powerful tool to investigate the spatial and temporal variability of observational data. In this work we analyse two sequences of self-potential values measured by means of a geophysical monitoring array located in a seismically active area of Southern Italy. The range of scales investigated goes from a few minutes to several days. It is shown that signal...

  2. Rapid growth, early maturation and short generation time in African annual fishes

    Czech Academy of Sciences Publication Activity Database

    Blažek, Radim; Polačik, Matej; Reichard, Martin

    2013-01-01

    Roč. 4, č. 24 (2013), s. 24 ISSN 2041-9139 R&D Projects: GA ČR(CZ) GAP506/11/0112 Institutional support: RVO:68081766 Keywords : extreme life history * annual fish * explosive growth * rapid maturation * generation time * killifish * diapause * vertebrate * reaction norm * Savanna Subject RIV: EG - Zoology Impact factor: 3.104, year: 2013 http://www.evodevojournal.com/content/4/1/24

  3. Time-Series Prediction: Application to the Short-Term Electric Energy Demand

    OpenAIRE

    Troncoso Lora, Alicia; Riquelme Santos, Jesús Manuel; Riquelme Santos, José Cristóbal; Gómez Expósito, Antonio; Martínez Ramos, José Luis

    2003-01-01

    This paper describes a time-series prediction method based on the kNN technique. The proposed methodology is applied to the 24-hour load forecasting problem. Also, based on recorded data, an alternative model is developed by means of a conventional dynamic regression technique, where the parameters are estimated by solving a least squares problem. Finally, results obtained from the application of both techniques to the Spanish transmission system are compared in terms of maximum, average and ...

  4. A Short Proof of the Large Time Energy Growth for the Boussinesq System

    Science.gov (United States)

    Brandolese, Lorenzo; Mouzouni, Charafeddine

    2017-10-01

    We give a direct proof of the fact that the L^p-norms of global solutions of the Boussinesq system in R^3 grow large as t→ ∞ for 1R+× R3. In particular, the kinetic energy blows up as \\Vert u(t)\\Vert _2^2˜ ct^{1/2} for large time. This contrasts with the case of the Navier-Stokes equations.

  5. Stress and Fatigue Management Using Balneotherapy in a Short-Time Randomized Controlled Trial

    OpenAIRE

    Rapolienė, Lolita; Razbadauskas, Artūras; Sąlyga, Jonas; Martinkėnas, Arvydas

    2016-01-01

    Objective. To investigate the influence of high-salinity geothermal mineral water on stress and fatigue. Method. 180 seamen were randomized into three groups: geothermal (65), music (50), and control (65). The geothermal group was administered 108?g/L salinity geothermal water bath for 2 weeks five times a week. Primary outcome was effect on stress and fatigue. Secondary outcomes were the effect on cognitive function, mood, and pain. Results. The improvements after balneotherapy were a reduct...

  6. Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

    International Nuclear Information System (INIS)

    Cox, Sophie C.; Jamshidi, Parastoo; Eisenstein, Neil M.; Webber, Mark A.; Hassanin, Hany; Attallah, Moataz M.; Shepherd, Duncan E.T.; Addison, Owen; Grover, Liam M.

    2016-01-01

    Additive manufacturing technologies have been utilised in healthcare to create patient-specific implants. This study demonstrates the potential to add new implant functionality by further exploiting the design flexibility of these technologies. Selective laser melting was used to manufacture titanium-based (Ti-6Al-4V) implants containing a reservoir. Pore channels, connecting the implant surface to the reservoir, were incorporated to facilitate antibiotic delivery. An injectable brushite, calcium phosphate cement, was formulated as a carrier vehicle for gentamicin. Incorporation of the antibiotic significantly (p = 0.01) improved the compressive strength (5.8 ± 0.7 MPa) of the cement compared to non-antibiotic samples. The controlled release of gentamicin sulphate from the calcium phosphate cement injected into the implant reservoir was demonstrated in short term elution studies using ultraviolet-visible spectroscopy. Orientation of the implant pore channels were shown, using micro-computed tomography, to impact design reproducibility and the back-pressure generated during cement injection which ultimately altered porosity. The amount of antibiotic released from all implant designs over a 6 hour period (< 28% of the total amount) were found to exceed the minimum inhibitory concentrations of Staphylococcus aureus (16 μg/mL) and Staphylococcus epidermidis (1 μg/mL); two bacterial species commonly associated with periprosthetic infections. Antibacterial efficacy was confirmed against both bacterial cultures using an agar diffusion assay. Interestingly, pore channel orientation was shown to influence the directionality of inhibition zones. Promisingly, this work demonstrates the potential to additively manufacture a titanium-based antibiotic eluting implant, which is an attractive alternative to current treatment strategies of periprosthetic infections. - Highlights: • Titanium implants were additively manufactured with surface connected reservoirs. • Implants

  7. Antipersistent dynamics in short time scale variability of self-potential signals

    Directory of Open Access Journals (Sweden)

    M. Ragosta

    2000-06-01

    Full Text Available Time scale properties of self-potential signals are investigated through the analysis of the second order structure function (variogram, a powerful tool to investigate the spatial and temporal variability of observational data. In this work we analyse two sequences of self-potential values measured by means of a geophysical monitoring array located in a seismically active area of Southern Italy. The range of scales investigated goes from a few minutes to several days. It is shown that signal fluctuations are characterised by two time scale ranges in which self-potential variability appears to follow slightly different dynamical behaviours. Results point to the presence of fractal, non stationary features expressing a long term correlation with scaling coefficients which are the clue of stabilising mechanisms. In the scale ranges in which the series show scale invariant behaviour, self-potentials evolve like fractional Brownian motions with anticorrelated increments typical of processes regulated by negative feedback mechanisms (antipersistence. On scales below about 6 h the strength of such an antipersistence appears to be slightly greater than that observed on larger time scales where the fluctuations are less efficiently stabilised.

  8. Effect of parameter calculation in direct estimation of the Lyapunov exponent in short time series

    Directory of Open Access Journals (Sweden)

    A. M. López Jiménez

    2002-01-01

    Full Text Available The literature about non-linear dynamics offers a few recommendations, which sometimes are divergent, about the criteria to be used in order to select the optimal calculus parameters in the estimation of Lyapunov exponents by direct methods. These few recommendations are circumscribed to the analysis of chaotic systems. We have found no recommendation for the estimation of λ starting from the time series of classic systems. The reason for this is the interest in distinguishing variability due to a chaotic behavior of determinist dynamic systems of variability caused by white noise or linear stochastic processes, and less in the identification of non-linear terms from the analysis of time series. In this study we have centered in the dependence of the Lyapunov exponent, obtained by means of direct estimation, of the initial distance and the time evolution. We have used generated series of chaotic systems and generated series of classic systems with varying complexity. To generate the series we have used the logistic map.

  9. Short-term dispersal response of an endangered Australian lizard varies with time of year.

    Directory of Open Access Journals (Sweden)

    Mehregan Ebrahimi

    Full Text Available Dispersal is an important component in the demography of animal populations. Many animals show seasonal changes in their tendency to disperse, reflecting changes in resource availability, mating opportunities, or in population age structure at the time when new offspring enter the population. Understanding when and why dispersal occurs can be important for the management of endangered species. The pygmy bluetongue lizard is an endangered Australian species that occupies and defends single burrow refuges for extended periods of time, rarely moving far from the burrow entrance. However, previous pitfall trapping data have suggested movement of adult males in spring and of juveniles in autumn of each year. In the current study we compared behaviours of adult lizards each month, over the spring-summer activity period over two consecutive field seasons, to provide deeper understanding of the seasonal dispersal pattern. We released adult pygmy bluetongue lizards into a central area, provided with artificial burrows, within large enclosures, and monitored the behaviour and movements of the released lizards over a four day period. There was a consistent decline in time spent basking, amount of movement around burrow entrances, and rates of dispersal from the central release area from early spring to late summer. Results could be relevant to understanding and managing natural populations and for any translocation attempts of this endangered lizard species.

  10. Short-time dynamics of phenylene-rings in bisphenol based engineering thermoplastics

    International Nuclear Information System (INIS)

    Arrese-Igor, S.; Arbe, A.; Alegria, A.; Colmenero, J.; Frick, B.

    2003-01-01

    We have recently performed one of the first approaches by means of quasielastic neutron scattering (QENS) to the problem of identifying the molecular motions giving rise to the secondary relaxations of engineering thermoplastics. Preliminary results point to phenylene ring π-flips as the main motion causing the observed quasielastic broadening in the ∼10 -10 -10 -9 s time scale below the glass transition temperature T g . Continuing our study of sub-T g dynamics in these systems by QENS, measurements on polycarbonate (PC) and polysulfone (PSF) with deuterated methyl groups (d6) in the ∼10 -13 -10 -11 s time scale have been performed. The intermediate scattering function shows a smooth second decay in addition to that of vibrations and 'fast dynamics' at T > or approx. 200 K. The extrapolation of phenylene π-flip motion to faster times does not explain the decay observed. However, a non-negligible contribution of π-flips at T≥350 K in PCd6 is noticeable, whereas for PSFd6 some effect can be inferred above ∼450 K. In the temperature region where the π-flips do not contribute to the spectra we have characterised the signal by assuming a temperature dependent distribution of small angle oscillations of phenylene rings leading to an activation energy of 0.18 eV

  11. Short communication: Pharmacokinetics of intramammary hetacillin in dairy cattle milked 3 times per day.

    Science.gov (United States)

    Lindquist, Danielle A; Baynes, Ronald E; Smith, Geof W

    2015-03-01

    Mastitis remains a critical disease in the dairy industry and the use of intramammary antibiotics plays a critical role in mastitis treatment. Hetacillin is currently approved as an intramammary antibiotic that is used to treat mastitis in dairy cows. It is approved for once a day administration and can be used for a total of 3 d. An increasing number of dairy farms are milking 3 times per day (instead of the traditional 2 times per day) and very little pharmacokinetic data exists on the use of intramammary drugs in a 3×system. The primary purpose of this study was to determine if once a day intramammary infusion of hetacillin is sufficient to maintain therapeutic drug concentrations in cattle milked 3 times per day. Eight Holstein cattle milked 3 times per day were used in this study. After collecting a baseline milk sample, each cow received intramammary infusions of hetacillin in the left front and right rear quarters once a day for 3 d. Milk samples from each of the treated quarters were collected at each milking and frozen until analysis. Milk samples were analyzed for ampicillin concentrations using an ultra-performance liquid chromatography method. All treated quarters had antibiotic concentrations well above the minimum inhibitory concentration (MIC) for gram-positive mastitis pathogens at 8 and 16 h postinfusion. Milk concentrations had fallen well below the MIC by the 24-h period (before the next infusion). All 8 cows in this study consistently had individual quarter milk ampicillin concentrations below the FDA tolerance of 0.01 μg/mL (10 ppb) within 48 h of the last infusion. Based on this study, milk ampicillin concentrations exceed the minimum inhibitory concentration required to inhibit the growth of 90% of organisms (MIC90) for at least 65% of the dosing interval, which is sufficient for once-daily dosing with most cases of gram-positive mastitis. Therefore, intramammary hetacillin should be an effective treatment for the vast majority of gram

  12. Pricing decision model for new and remanufactured short-life cycle products with time-dependent demand

    Directory of Open Access Journals (Sweden)

    Shu San Gan

    2015-12-01

    Full Text Available In this study we develop a model that optimizes the price for new and remanufactured short life-cycle products where demands are time-dependent and price sensitive. While there has been very few published works that attempt to model remanufacturing decisions for products with short life cycle, we believe that there are many situations where remanufacturing short life cycle products is rewarding economically as well as environmentally. The system that we model consists of a retailer, a manufacturer, and a collector of used product from the end customers. Two different scenarios are evaluated for the system. The first is the independent situation where each party attempts to maximize his/her own total profit and the second is the joint profit model where we optimize the combined total profit for all three members of the supply chain. Manufacturer acts as the Stackelberg leader in the independently optimized scenario, while in the other the intermediate prices are determined by coordinated pricing policy. The results suggest that (i reducing the price of new products during the decline phase does not give better profit for the whole system, (ii the total profit obtained from optimizing each player is lower than the total profit of the integrated model, and (iii speed of change in demand influences the robustness of the prices as well as the total profit gained.

  13. No Clear Association between Impaired Short-Term or Working Memory Storage and Time Reproduction Capacity in Adult ADHD Patients.

    Science.gov (United States)

    Mette, Christian; Grabemann, Marco; Zimmermann, Marco; Strunz, Laura; Scherbaum, Norbert; Wiltfang, Jens; Kis, Bernhard

    2015-01-01

    Altered time reproduction is exhibited by patients with adult attention deficit hyperactivity disorder (ADHD). It remains unclear whether memory capacity influences the ability of adults with ADHD to reproduce time intervals. We conducted a behavioral study on 30 ADHD patients who were medicated with methylphenidate, 29 unmedicated adult ADHD patients and 32 healthy controls (HCs). We assessed time reproduction using six time intervals (1 s, 4 s, 6 s, 10 s, 24 s and 60 s) and assessed memory performance using the Wechsler memory scale. The patients with ADHD exhibited lower memory performance scores than the HCs. No significant differences in the raw scores for any of the time intervals (p > .05), with the exception of the variability at the short time intervals (1 s, 4 s and 6 s) (p memory performance (p > .05). We detected no findings indicating that working memory might influence time reproduction in adult patients with ADHD. Therefore, further studies concerning time reproduction and memory capacity among adult patients with ADHD must be performed to verify and replicate the present findings.

  14. No Clear Association between Impaired Short-Term or Working Memory Storage and Time Reproduction Capacity in Adult ADHD Patients.

    Directory of Open Access Journals (Sweden)

    Christian Mette

    Full Text Available Altered time reproduction is exhibited by patients with adult attention deficit hyperactivity disorder (ADHD. It remains unclear whether memory capacity influences the ability of adults with ADHD to reproduce time intervals.We conducted a behavioral study on 30 ADHD patients who were medicated with methylphenidate, 29 unmedicated adult ADHD patients and 32 healthy controls (HCs. We assessed time reproduction using six time intervals (1 s, 4 s, 6 s, 10 s, 24 s and 60 s and assessed memory performance using the Wechsler memory scale.The patients with ADHD exhibited lower memory performance scores than the HCs. No significant differences in the raw scores for any of the time intervals (p > .05, with the exception of the variability at the short time intervals (1 s, 4 s and 6 s (p .05.We detected no findings indicating that working memory might influence time reproduction in adult patients with ADHD. Therefore, further studies concerning time reproduction and memory capacity among adult patients with ADHD must be performed to verify and replicate the present findings.

  15. Microbial inactivation of paprika by a high-temperature short-X time treatment. Influence on color properties.

    Science.gov (United States)

    Almela, Luis; Nieto-Sandoval, José M; Fernández López, José A

    2002-03-13

    High-temperature short-time (HTST) treatments have been used to destroy the bioburden of paprika. With this in mind, we have designed a device to treat samples of paprika with a gas whose temperature, pressure, and composition can be selected. Temperatures and treatment times ranged from 130 to 170 degrees C and 4 to 6 s, respectively. The survival of the most commonly found microorganisms in paprika and any alteration in extractable and superficial color were examined. Data showed that the optimum HTST conditions were 145 degrees C, 1.5 kg/cm2 of overpressure, 6 s operation time, and a thermal fluid of saturated steam. No microbial growth was detected during storage after thermal treatment. To minimize the color losses, treated (HTST) paprika samples should be kept under refrigeration.

  16. Performance Analysis of the Enhanced DSR Routing Protocol for the Short Time Disconnected MANET to the OPNET Modeler

    Directory of Open Access Journals (Sweden)

    PAPAJ Ján

    2013-05-01

    Full Text Available Disconnected mobile ad-hoc networks (MANET are very important areas of the research. In this article, the performance analysis of the enhanced dynamic source routing protocol (OPP_DSR is introduced. This modification enables the routing process in the case when there are no connections to other mobile nodes. It also will enable the routing mechanisms when the routes, selected by routing mechanisms, are disconnected for some time. Disconnection can be for a short time and standard routing protocol DSR cannot reflect on this situation.The main idea is based on opportunistic forwarding where the nodes not only forward data but it's stored in the cache during long time. The network parameters throughput, routing load and are analysed.

  17. [Effect of short-time drought process on denitrifying bacteria abundance and N2O emission in paddy soil].

    Science.gov (United States)

    Lu, Jing; Liu, Jin-Bo; Sheng, Rong; Liu, Yi; Chen, An-Lei; Wei, Wen-Xue

    2014-10-01

    In order to investigate the impact of drying process on greenhouse gas emissions and denitrifying microorganisms in paddy soil, wetting-drying process was simulated in laboratory conditions. N2O flux, redox potential (Eh) were monitored and narG- and nosZ-containing denitrifiers abundances were determined by real-time PCR. N2O emission was significantly increased only 4 h after drying process began, and it was more than 6 times of continuous flooding (CF) at 24 h. In addition, narG and nosZ gene abundances were increased rapidly with the drying process, and N2O emission flux was significantly correlated with narG gene abundance (P driving microorganisms which caused the N2O emission in the short-time drought process in paddy soil.

  18. Analysis of short time-space range seismicity patterns in Italy

    Directory of Open Access Journals (Sweden)

    M. Imotof

    1997-06-01

    Full Text Available In our paper we analyze the data base obtained from the observations of the Italian Seismological Network from 1975 to 1994 by using a simple algotithm to determine the rate of occurrence of seismic events condi- tioned by the occurrence of previous events after a period of quiescence. The number of observed pairs of earthquakes depends on several parameters: the magnitude threshold of the two events, the spatial and tempo- ral ranges of the quiescence period preceding the first (non aftershock event, the time elapsed between the first and the second events and the spatial dimension of the alarm area. The Akaike information criterion was adopted to assess the optimal set of space-time parameters used in the definition of non-aftershock (events not related to a stronger previous one. In Central Italy, the rate of M ³3.8 earthquakes preceded by at least one M ~ 3.3 foreshock within 14.1 km and 2 days is 30%, while the rate of M ~ 3.3 earthquakes followed by a M ~ 3.8 mainshock in the same space time range is 7%. We observed that the probability that an earthquake of magnitude MI will be followed by an earthquake of magnitude M2 (success rate fits the law log À = a+b (Mi -M2 with b approximately equal to l. By computing the success rate for given values of magnitude threshold of the first and the second events over a dense grid of spatial coordinates, we obtained maps of this feature over the investigated area. The results of this process document variations larger than a factor of five in the success rate over the Italian territory.

  19. Five-Kilometers Time Trial: Preliminary Validation of a Short Test for Cycling Performance Evaluation.

    Science.gov (United States)

    Dantas, Jose Luiz; Pereira, Gleber; Nakamura, Fabio Yuzo

    2015-09-01

    The five-kilometer time trial (TT5km) has been used to assess aerobic endurance performance without further investigation of its validity. This study aimed to perform a preliminary validation of the TT5km to rank well-trained cyclists based on aerobic endurance fitness and assess changes of the aerobic endurance performance. After the incremental test, 20 cyclists (age = 31.3 ± 7.9 years; body mass index = 22.7 ± 1.5 kg/m(2); maximal aerobic power = 360.5 ± 49.5 W) performed the TT5km twice, collecting performance (time to complete, absolute and relative power output, average speed) and physiological responses (heart rate and electromyography activity). The validation criteria were pacing strategy, absolute and relative reliability, validity, and sensitivity. Sensitivity index was obtained from the ratio between the smallest worthwhile change and typical error. The TT5km showed high absolute (coefficient of variation 0.95) reliability of performance variables, whereas it presented low reliability of physiological responses. The TT5km performance variables were highly correlated with the aerobic endurance indices obtained from incremental test (r > 0.70). These variables showed adequate sensitivity index (> 1). TT5km is a valid test to rank the aerobic endurance fitness of well-trained cyclists and to differentiate changes on aerobic endurance performance. Coaches can detect performance changes through either absolute (± 17.7 W) or relative power output (± 0.3 W.kg(-1)), the time to complete the test (± 13.4 s) and the average speed (± 1.0 km.h(-1)). Furthermore, TT5km performance can also be used to rank the athletes according to their aerobic endurance fitness.

  20. Vision-based online vibration estimation of the in-vessel inspection flexible robot with short-time Fourier transformation

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Hesheng [Key Laboratory of System Control and Information Processing, Ministry of Education of China (China); Department of Automation, Shanghai Jiao Tong University, Shanghai 200240 (China); Chen, Weidong, E-mail: wdchen@sjtu.edu.cn [Key Laboratory of System Control and Information Processing, Ministry of Education of China (China); Department of Automation, Shanghai Jiao Tong University, Shanghai 200240 (China); Xu, Lifei; He, Tao [Key Laboratory of System Control and Information Processing, Ministry of Education of China (China); Department of Automation, Shanghai Jiao Tong University, Shanghai 200240 (China)

    2015-10-15

    Highlights: • Vision-based online vibration estimation method for a flexible arm is proposed. • The vibration signal is obtained by image processing in unknown environments. • Vibration parameters are estimated by short-time Fourier transformation. - Abstract: The vibration should be suppressed if it happens during the motion of a flexible robot or under the influence of external disturbance caused by its structural features and material properties, because the vibration may affect the positioning accuracy and image quality. In Tokamak environment, we need to get the real-time vibration information on vibration suppression of robotic arm, however, some sensors are not allowed in the extreme Tokamak environment. This paper proposed a vision-based method for online vibration estimation of a flexible manipulator, which is achieved by utilizing the environment image information from the end-effector camera to estimate its vibration. Short-time Fourier Transformation with adaptive window length method is used to estimate vibration parameters of non-stationary vibration signals. Experiments with one-link flexible manipulator equipped with camera are carried out to validate the feasibility of this method in this paper.

  1. Gamma spectrometric characterization of short cooling time nuclear spent fuels using hemispheric CdZnTe detectors

    CERN Document Server

    Lebrun, A; Szabó, J L; Arenas-Carrasco, J; Arlt, R; Dubreuil, A; Esmailpur-Kazerouni, K

    2000-01-01

    After years of cooling, nuclear spent fuel gamma emissions are mainly due to caesium isotopes which are emitters at 605, 662 and 796-801 keV. Extensive work has been done on such fuels using various CdTe or CdZnTe probes. When fuels have to be measured after short cooling time (during NPP outage) the spectrum is much more complex due to the important contributions of niobium and zirconium in the 700 keV range. For the first time in a nuclear power plant, four spent fuels of the Kozloduy VVER reactor no 4 were measured during outage, 37 days after shutdown of the reactor. In such conditions, good resolution is of particular interest, so a 20 mm sup 3 hemispheric crystal was used with a resolution better than 7 keV at 662 keV. This paper presents the experimental device and analyzes the results which show that CdZnTe commercially available detectors enabled us to perform a semi-quantitative determination of the burn-up after a short cooling time. In addition, it is discussed how a burn-up evolution code (CESAR)...

  2. Vision-based online vibration estimation of the in-vessel inspection flexible robot with short-time Fourier transformation

    International Nuclear Information System (INIS)

    Wang, Hesheng; Chen, Weidong; Xu, Lifei; He, Tao

    2015-01-01

    Highlights: • Vision-based online vibration estimation method for a flexible arm is proposed. • The vibration signal is obtained by image processing in unknown environments. • Vibration parameters are estimated by short-time Fourier transformation. - Abstract: The vibration should be suppressed if it happens during the motion of a flexible robot or under the influence of external disturbance caused by its structural features and material properties, because the vibration may affect the positioning accuracy and image quality. In Tokamak environment, we need to get the real-time vibration information on vibration suppression of robotic arm, however, some sensors are not allowed in the extreme Tokamak environment. This paper proposed a vision-based method for online vibration estimation of a flexible manipulator, which is achieved by utilizing the environment image information from the end-effector camera to estimate its vibration. Short-time Fourier Transformation with adaptive window length method is used to estimate vibration parameters of non-stationary vibration signals. Experiments with one-link flexible manipulator equipped with camera are carried out to validate the feasibility of this method in this paper.

  3. Devolatilization kinetics of woody biomass at short residence times and high heating rates and peak temperatures

    DEFF Research Database (Denmark)

    Johansen, Joakim M.; Gadsbøll, Rasmus; Thomsen, Jesper

    2016-01-01

    This work combines experimental and computational fluid dynamics (CFD) results to derive global kinetics for biomass (pine wood) devolatilization during heating rates on the order of 105Ks-1, bulk flow peak temperatures between 1405 and 1667K, and particle residence times below 0.1s. Experiments......Jmol-1. The accuracy of the derived global kinetics was supported by comparing predictions to experimental results from a 15kW furnace. The work emphasizes the importance of characterizing the temperature history of the biomass particles when deriving pyrolysis kinetics. The present results indicate...

  4. Antimicrobial and antiviral effect of high-temperature short-time (HTST) pasteurization applied to human milk.

    Science.gov (United States)

    Terpstra, Fokke G; Rechtman, David J; Lee, Martin L; Hoeij, Klaske Van; Berg, Hijlkeline; Van Engelenberg, Frank A C; Van't Wout, Angelica B

    2007-03-01

    In the United States, concerns over the transmission of infectious diseases have led to donor human milk generally being subjected to pasteurization prior to distribution and use. The standard method used by North American milk banks is Holder pasteurization (63 degrees C for 30 minutes). The authors undertook an experiment to validate the effects of a high-temperature short-time (HTST) pasteurization process (72 degrees C for 16 seconds) on the bioburden of human milk. It was concluded that HTST is effective in the elimination of bacteria as well as of certain important pathogenic viruses.

  5. Fetal short time variation during labor: a non-invasive alternative to fetal scalp pH measurements?

    OpenAIRE

    Schiermeier, Sven; Reinhard, Joscha; Hatzmann, Hendrike; Zimmermann, Ralf C.; Westhof, Gregor

    2009-01-01

    Objective: To determine whether short time variation (STV) of fetal heart beat correlates with scalp pH measurements during labor. Patients and methods: From 1279 deliveries, 197 women had at least one fetal scalp pH measurement. Using the CTG-Player®, STVs were calculated from the electronically saved cardiotocography (CTG) traces and related to the fetal scalp pH measurements. Results: There was no correlation between STV and fetal scalp pH measurements (r=−0.0592). Conclusions: Fetal ST...

  6. Short-time dynamics of random-bond Potts ferromagnet with continuous self-dual quenched disorders

    OpenAIRE

    Pan, Z. Q.; Ying, H. P.; Gu, D. W.

    2001-01-01

    We present Monte Carlo simulation results of random-bond Potts ferromagnet with the Olson-Young self-dual distribution of quenched disorders in two-dimensions. By exploring the short-time scaling dynamics, we find universal power-law critical behavior of the magnetization and Binder cumulant at the critical point, and thus obtain estimates of the dynamic exponent $z$ and magnetic exponent $\\eta$, as well as the exponent $\\theta$. Our special attention is paid to the dynamic process for the $q...

  7. Application of rat mast cell incubates as a possible short-time test for sensitizing occupational chemicals

    Energy Technology Data Exchange (ETDEWEB)

    Diel, F.; Neidhart, B.; Opree, W.

    1981-08-01

    The direct action of sensitizing occupational chemicals (formaldehyde, phenol, phenylhydrazine, p-aminophenol) on rat mast cells was investigated by determination of histamine using HPLC separation and fluorimetric detection. It turned out that dispersed mast cells from immunized and non-immunized Wistar-rats are more sensitive than small-cut lung tissue slices. Passive cutaneous anaphylaxis was negative after a fortnight sensitizing experiment with the here described occupational chemicals. Short-time tests with rat mast cells reflect anaphylactoid response and are suitable for the screening of sensitizing chemicals.

  8. A short essay on quantum black holes and underlying noncommutative quantized space-time

    International Nuclear Information System (INIS)

    Tanaka, Sho

    2017-01-01

    We emphasize the importance of noncommutative geometry or Lorenz-covariant quantized space-time towards the ultimate theory of quantum gravity and Planck scale physics. We focus our attention on the statistical and substantial understanding of the Bekenstein–Hawking area-entropy law of black holes in terms of the kinematical holographic relation (KHR). KHR manifestly holds in Yang’s quantized space-time as the result of kinematical reduction of spatial degrees of freedom caused by its own nature of noncommutative geometry, and plays an important role in our approach without any recourse to the familiar hypothesis, so-called holographic principle. In the present paper, we find a unified form of KHR applicable to the whole region ranging from macroscopic to microscopic scales in spatial dimension d   =  3. We notice a possibility of nontrivial modification of area-entropy law of black holes which becomes most remarkable in the extremely microscopic system close to Planck scale. (paper)

  9. Control of insects and mites in grain using a high temperature/short time (HTST) technique.

    Science.gov (United States)

    Mourier; Poulsen

    2000-07-01

    Wheat infested with grain mites (Acari) and Sitophilus granarius, and maize infested with Prostephanus truncatus, were exposed to hot air in a CIMBRIA HTST Microline toaster((R)). Inlet temperatures of the hot air were in the range of 150-750 degrees C decreasing to outlet temperatures in the range of 100-300 degrees C during the exposure period. A rotating drum, connected to a natural-gas burner was fed with grain which was in constant movement along the drum and thereby mixed thoroughly during the process. The capacity of the toaster was 1000 kg per hour.Complete control of grain mites and adult S. granarius in wheat was obtained with an inlet temperature of 300-350 degrees C and an average residence time in the drum of 6 s. More than 99% mortality was obtained for all stages of S. granarius with an inlet temperature of 300-350 degrees C and an average exposure period of 40 s. For control of P. truncatus in maize, an inlet temperature of 700 degrees C resulted in a complete disinfestation when the exposure time was 19 s.The reduction in grain moisture content was 0.5-1% at treatments giving 100% control. Germination tests indicate that it is possible to choose a combination of inlet temperatures and exposure periods which effectively kills mites and insects in small grains, without harming the functional properties of the grain.Economy of the method was considered to be competitive with fumigation using phosphine.

  10. Scenario-Based Case Study Analysis of Asteroid Mitigation in the Short Response Time Regime

    Science.gov (United States)

    Seery, B.; Greenaugh, K. C.

    2017-12-01

    Asteroid impact on Earth is a rare but inevitable occurrence, with potentially cataclysmic consequences. If a pending impact is discovered, mitigation options include civil-defense preparations as well as missions to deflect the asteroid and/or robustly disrupt and disperse it to an extent that only a negligible fraction remains on a threatening path (National Research Council's "Defending the Planet," 2010). If discovered with sufficient warning time, a kinetic impactor can deflect smaller objects, but response delays can rule out the option. If a body is too large to deflect by kinetic impactor, or the time for response is insufficient, deflection or disruption can be achieved with a nuclear device. The use of nuclear ablation is considered within the context of current capabilities, requiring no need for nuclear testing. Existing, well-understood devices are sufficient for the largest known Potentially Hazardous Objects (PHOs). The National Aeronautics and Space Administration/Goddard Space Flight Center and the Department of Energy/National Nuclear Security Administration are collaborating to determine the critical characterization issues that define the boundaries for the asteroid-deflection options. Drawing from such work, we examine the timeline for a deflection mission, and how to provide the best opportunity for an impactor to suffice by minimizing the response time. This integrated problem considers the physical process of the deflection method (impact or ablation), along with the spacecraft, launch capability, risk analysis, and the available intercept flight trajectories. Our joint DOE/NASA team has conducted case study analysis of three distinctly different PHOs, on a hypothetical earth impacting trajectory. The size of the design reference bodies ranges from 100 - 500 meters in diameter, with varying physical parameters such as composition, spin state, and metallicity, to name a few. We assemble the design reference of the small body in question using

  11. Short-time, high temperature mechanical testing of electrically conductive materials

    International Nuclear Information System (INIS)

    Marion, R.H.; Karnes, C.H.

    1975-10-01

    Design and performance details are given for a facility which was developed to obtain the mechanical properties of materials under high heating rate or transient temperature conditions and medium strain rates. The system is shown to be applicable to materials possessing electrical resistivities ranging from that of aluminum to that of graphite without taxing the heating capability. Heating rates as high as 2000 0 K/s in graphite are attained under controlled conditions. Methods of measuring temperature and the effects of expected temperature distributions are discussed. A method for measuring strain valid for transient temperature conditions to 3000 0 K is described. Results are presented for the stress-strain behavior of 316 stainless steel and ATJ(S) graphite obtained for heating times of a few seconds. (auth)

  12. Online Identification of a Mechanical System in the Frequency Domain with Short-Time DFT

    Directory of Open Access Journals (Sweden)

    Niko Nevaranta

    2015-07-01

    Full Text Available A proper system identification method is of great importance in the process of acquiring an analytical model that adequately represents the characteristics of the monitored system. While the use of different time-domain online identification techniques has been widely recognized as a powerful approach for system diagnostics, the frequency domain identification techniques have primarily been considered for offline commissioning purposes. This paper addresses issues in the online frequency domain identification of a flexible two-mass mechanical system with varying dynamics, and a particular attention is paid to detect the changes in the system dynamics. An online identification method is presented that is based on a recursive Kalman filter configured to perform like a discrete Fourier transform (DFT at a selected set of frequencies. The experimental online identification results are compared with the corresponding values obtained from the offline-identified frequency responses. The results show an acceptable agreement and demonstrate the feasibility of the proposed identification method.

  13. A short-time scale colloidal system reveals early bacterial adhesion dynamics.

    Directory of Open Access Journals (Sweden)

    Christophe Beloin

    2008-07-01

    Full Text Available The development of bacteria on abiotic surfaces has important public health and sanitary consequences. However, despite several decades of study of bacterial adhesion to inert surfaces, the biophysical mechanisms governing this process remain poorly understood, due, in particular, to the lack of methodologies covering the appropriate time scale. Using micrometric colloidal surface particles and flow cytometry analysis, we developed a rapid multiparametric approach to studying early events in adhesion of the bacterium Escherichia coli. This approach simultaneously describes the kinetics and amplitude of early steps in adhesion, changes in physicochemical surface properties within the first few seconds of adhesion, and the self-association state of attached and free-floating cells. Examination of the role of three well-characterized E. coli surface adhesion factors upon attachment to colloidal surfaces--curli fimbriae, F-conjugative pilus, and Ag43 adhesin--showed clear-cut differences in the very initial phases of surface colonization for cell-bearing surface structures, all known to promote biofilm development. Our multiparametric analysis revealed a correlation in the adhesion phase with cell-to-cell aggregation properties and demonstrated that this phenomenon amplified surface colonization once initial cell-surface attachment was achieved. Monitoring of real-time physico-chemical particle surface properties showed that surface-active molecules of bacterial origin quickly modified surface properties, providing new insight into the intricate relations connecting abiotic surface physicochemical properties and bacterial adhesion. Hence, the biophysical analytical method described here provides a new and relevant approach to quantitatively and kinetically investigating bacterial adhesion and biofilm development.

  14. Short-term forecasting of meteorological time series using Nonparametric Functional Data Analysis (NPFDA)

    Science.gov (United States)

    Curceac, S.; Ternynck, C.; Ouarda, T.

    2015-12-01

    Over the past decades, a substantial amount of research has been conducted to model and forecast climatic variables. In this study, Nonparametric Functional Data Analysis (NPFDA) methods are applied to forecast air temperature and wind speed time series in Abu Dhabi, UAE. The dataset consists of hourly measurements recorded for a period of 29 years, 1982-2010. The novelty of the Functional Data Analysis approach is in expressing the data as curves. In the present work, the focus is on daily forecasting and the functional observations (curves) express the daily measurements of the above mentioned variables. We apply a non-linear regression model with a functional non-parametric kernel estimator. The computation of the estimator is performed using an asymmetrical quadratic kernel function for local weighting based on the bandwidth obtained by a cross validation procedure. The proximities between functional objects are calculated by families of semi-metrics based on derivatives and Functional Principal Component Analysis (FPCA). Additionally, functional conditional mode and functional conditional median estimators are applied and the advantages of combining their results are analysed. A different approach employs a SARIMA model selected according to the minimum Akaike (AIC) and Bayessian (BIC) Information Criteria and based on the residuals of the model. The performance of the models is assessed by calculating error indices such as the root mean square error (RMSE), relative RMSE, BIAS and relative BIAS. The results indicate that the NPFDA models provide more accurate forecasts than the SARIMA models. Key words: Nonparametric functional data analysis, SARIMA, time series forecast, air temperature, wind speed

  15. Time perspective in hereditary cancer: psychometric properties of a short form of the Zimbardo Time Perspective Inventory in a community and clinical sample.

    Science.gov (United States)

    Wakefield, Claire E; Homewood, Judi; Taylor, Alan; Mahmut, Mehmet; Meiser, Bettina

    2010-10-01

    We aimed to assess the psychometric properties of a 25-item short form of the Zimbardo Time Perspective Inventory in a community sample (N = 276) and in individuals with a strong family history of cancer, considering genetic testing for cancer risk (N = 338). In the community sample, individuals with high past-negative or present-fatalistic scores had higher levels of distress, as measured by depression, anxiety, and aggression. Similarly, in the patient sample, past-negative time perspective was positively correlated with distress, uncertainty, and postdecision regret when making a decision about genetic testing. Past-negative-oriented individuals were also more likely to be undecided about, or against, genetic testing. Hedonism was associated with being less likely to read the educational materials they received at their clinic, and fatalism was associated with having lower knowledge levels about genetic testing. The assessment of time perspective in individuals at increased risk of cancer can provide valuable clinical insights. However, further investigation of the psychometric properties of the short form of this scale is warranted, as it did not meet the currently accepted criteria for psychometric validation studies.

  16. Metabolic changes in the normal ageing brain: Consistent findings from short and long echo time proton spectroscopy

    International Nuclear Information System (INIS)

    Gruber, S.; Pinker, K.; Riederer, F.; Chmelik, M.; Stadlbauer, A.; Bittsansky, M.; Mlynarik, V.; Frey, R.; Serles, W.; Bodamer, O.; Moser, E.

    2008-01-01

    Objectives: Sixty three healthy subjects were measured to assess dependence of brain metabolites on age using short- and long echo time spectroscopy in different brain regions. Material and methods: Younger and elderly humans were measured with long echo time (TE = 135 ms) 3D-MR-spectroscopic imaging (MRSI) (10 subjects) and with ultra-short echo (TE = 11 ms) time 2D-MRSI (7 subjects). In addition, results from single voxel 1 H-spectroscopy (TE = 20 ms) of two cohorts of 46 healthy subjects were retrospectively correlated with age. Results: 3D-MR SI revealed reduced NAA/Cr in the older group in the frontal lobe (-22%; p < 0.01), parietal lobe (-28%; p < 0.01) and semiovale (-9%; p < 0.01) compared to the younger group. Cho/Cr was elevated in the semiovale (+35%; p < 0.01) and in the n. lentiformis (+42%; p < 0.01) in the older group. NAA/Cho was reduced in all regions measured, except the thalamus, in the older group compared to the younger group (from -21 to -49%; p < 0.01). 2D-MRSI revealed decreased total NAA (-3.1% per decade; p < 0.01) and NAA/Cr (-3.8% per decade; p < 0.01), increased total Cho (+3.6% per decade; p < 0.01) and Cho/Cr (+4.6% per decade; p < 0.01) and increased total myo-Inositol (mI, +4.7% per decade; p < 0.01) and mI/Cr (+5.4% per decade; p < 0.01) and decreased NAA/Cho (-8% per decade; p < 0.01) in semiovale WM. Results from single voxel spectroscopy revealed a significantly negative correlation of NAA/Cho in frontal (-13% per decade; p < 0.01) and in temporal lobe (-7.4% per decade; p < 0.01) as well as increased total Cr (10% per decade; p < 0.01) in frontal lobe. Other results from single voxel measurements were not significant, but trends were comparable to that from multivoxel spectroscopy. Conclusion: Age-related changes measured with long echo time and short echo time 1H-MRS were comparable and cannot, therefore, be caused by different T2 relaxation times in young and old subjects, as suggested previously

  17. Sirolimus-eluting versus bare-metal stent implantation in patients with ostial lesions

    DEFF Research Database (Denmark)

    Jørgensen, Erik; Kelbæk, Henning; Kløvgaard, Lene

    2010-01-01

    To investigate the efficacy of implantation of sirolimus-eluting stents (SES) in the ostium of coronary arteries.......To investigate the efficacy of implantation of sirolimus-eluting stents (SES) in the ostium of coronary arteries....

  18. Stress and Fatigue Management Using Balneotherapy in a Short-Time Randomized Controlled Trial

    Science.gov (United States)

    Razbadauskas, Artūras; Sąlyga, Jonas; Martinkėnas, Arvydas

    2016-01-01

    Objective. To investigate the influence of high-salinity geothermal mineral water on stress and fatigue. Method. 180 seamen were randomized into three groups: geothermal (65), music (50), and control (65). The geothermal group was administered 108 g/L salinity geothermal water bath for 2 weeks five times a week. Primary outcome was effect on stress and fatigue. Secondary outcomes were the effect on cognitive function, mood, and pain. Results. The improvements after balneotherapy were a reduction in the number and intensity of stress-related symptoms, a reduction in pain and general, physical, and mental fatigue, and an improvement in stress-related symptoms management, mood, activation, motivation, and cognitive functions with effect size from 0.8 to 2.3. In the music therapy group, there were significant positive changes in the number of stress symptoms, intensity, mood, pain, and activity with the effect size of 0.4 to 1.1. The researchers did not observe any significant positive changes in the control group. The comparison between the groups showed that balneotherapy was superior to music therapy and no treatment group. Conclusions. Balneotherapy is beneficial for stress and fatigue reduction in comparison with music or no therapy group. Geothermal water baths have a potential as an efficient approach to diminish stress caused by working or living conditions. PMID:27051455

  19. Stress and Fatigue Management Using Balneotherapy in a Short-Time Randomized Controlled Trial

    Directory of Open Access Journals (Sweden)

    Lolita Rapolienė

    2016-01-01

    Full Text Available Objective. To investigate the influence of high-salinity geothermal mineral water on stress and fatigue. Method. 180 seamen were randomized into three groups: geothermal (65, music (50, and control (65. The geothermal group was administered 108 g/L salinity geothermal water bath for 2 weeks five times a week. Primary outcome was effect on stress and fatigue. Secondary outcomes were the effect on cognitive function, mood, and pain. Results. The improvements after balneotherapy were a reduction in the number and intensity of stress-related symptoms, a reduction in pain and general, physical, and mental fatigue, and an improvement in stress-related symptoms management, mood, activation, motivation, and cognitive functions with effect size from 0.8 to 2.3. In the music therapy group, there were significant positive changes in the number of stress symptoms, intensity, mood, pain, and activity with the effect size of 0.4 to 1.1. The researchers did not observe any significant positive changes in the control group. The comparison between the groups showed that balneotherapy was superior to music therapy and no treatment group. Conclusions. Balneotherapy is beneficial for stress and fatigue reduction in comparison with music or no therapy group. Geothermal water baths have a potential as an efficient approach to diminish stress caused by working or living conditions.

  20. Indications of energetic consequences of decoherence at short times for scattering from open quantum systems

    Directory of Open Access Journals (Sweden)

    C. A. Chatzidimitriou-Dreismann

    2011-06-01

    Full Text Available Decoherence of quantum entangled particles is observed in most systems, and is usually caused by system-environment interactions. Disentangling two subsystems A and B of a quantum system AB is tantamount to erasure of quantum phase relations between A and B. It is widely believed that this erasure is an innocuous process, which e.g. does not affect the energies of A and B. Surprisingly, recent theoretical investigations by different groups showed that disentangling two systems, i.e. their decoherence, can cause an increase of their energies. Applying this result to the context of neutron Compton scattering from H2 molecules, we provide for the first time experimental evidence which supports this prediction. The results reveal that the neutron-proton collision leading to the cleavage of the H-H bond in the sub-femtosecond timescale is accompanied by larger energy transfer (by about 3% than conventional theory predicts. It is proposed to interpreted the results by considering the neutron-proton collisional system as an entangled open quantum system being subject to decoherence owing to the interactions with the “environment” (i.e., two electrons plus second proton of H2.

  1. The time course of short-term hypertrophy in the absence of eccentric muscle damage.

    Science.gov (United States)

    Stock, Matt S; Mota, Jacob A; DeFranco, Ryan N; Grue, Katherine A; Jacobo, A Unique; Chung, Eunhee; Moon, Jordan R; DeFreitas, Jason M; Beck, Travis W

    2017-05-01

    It has been proposed that the increase in skeletal muscle mass observed during the initial weeks of initiating a resistance training program is concomitant with eccentric muscle damage and edema. We examined the time course of muscle hypertrophy during 4 weeks of concentric-only resistance training. Thirteen untrained men performed unilateral concentric-only dumbbell curls and shoulder presses twice per week for 4 weeks. Sets of 8-12 repetitions were performed to failure, and training loads were increased during each session. Subjects consumed 500 ml of whole milk during training. Assessments of soreness, lean mass, echo intensity, muscle thickness, relaxed and flexed arm circumference, and isokinetic strength were performed every 72 or 96 h. Soreness, echo intensity, relaxed circumference, and peak torque data did not significantly change. Significant increases in lean mass, muscle thickness, and flexed circumference were observed within seven training sessions. Lean mass was elevated at tests #7 (+109.3 g, p = .002) and #8 (+116.1 g, p = .035), with eight different subjects showing changes above the minimal difference of 139.1 g. Muscle thickness was elevated at tests #6 (+0.23 cm, p = .004), #7 (+0.31 cm, p hypertrophy may occur in the absence of eccentric muscle damage within seven training sessions.

  2. Norwegian reference values for the Short-Form Health Survey 36: development over time.

    Science.gov (United States)

    Jacobsen, Ellisiv L; Bye, Asta; Aass, Nina; Fosså, Sophie D; Grotmol, Kjersti S; Kaasa, Stein; Loge, Jon Håvard; Moum, Torbjørn; Hjermstad, Marianne J

    2018-05-01

    Reference values for patient-reported outcome measures are useful for interpretation of results from clinical trials. The study aims were to collect Norwegian SF-36 reference values and compare with data from 1996 to 2002. In 2015, SF-36 was sent by mail to a representative sample of the population (N = 6165). Time trends and associations between background variables and SF-36 scale scores were compared by linear regression models. The 2015 response rate was 36% (N = 2118) versus 67% (N = 2323) in 1996 and 56% (N = 5241) in 2002. Only 5% of the youngest (18-29 years) and 27% of the oldest (>70 years) responded in 2015. Age and educational level were significantly higher in 2015 relative to 1996/2002 (p 36 scores were relatively stable across surveys, controlled for background variables. In general, the most pronounced changes in 2015 were better scores on the role limitations emotional scale (7.4 points, p 70 years. Despite societal changes in Norway the past two decades, HRQoL has remained relatively stable.

  3. Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants.

    Science.gov (United States)

    Cox, Sophie C; Jamshidi, Parastoo; Eisenstein, Neil M; Webber, Mark A; Hassanin, Hany; Attallah, Moataz M; Shepherd, Duncan E T; Addison, Owen; Grover, Liam M

    2016-07-01

    Additive manufacturing technologies have been utilised in healthcare to create patient-specific implants. This study demonstrates the potential to add new implant functionality by further exploiting the design flexibility of these technologies. Selective laser melting was used to manufacture titanium-based (Ti-6Al-4V) implants containing a reservoir. Pore channels, connecting the implant surface to the reservoir, were incorporated to facilitate antibiotic delivery. An injectable brushite, calcium phosphate cement, was formulated as a carrier vehicle for gentamicin. Incorporation of the antibiotic significantly (p=0.01) improved the compressive strength (5.8±0.7MPa) of the cement compared to non-antibiotic samples. The controlled release of gentamicin sulphate from the calcium phosphate cement injected into the implant reservoir was demonstrated in short term elution studies using ultraviolet-visible spectroscopy. Orientation of the implant pore channels were shown, using micro-computed tomography, to impact design reproducibility and the back-pressure generated during cement injection which ultimately altered porosity. The amount of antibiotic released from all implant designs over a 6hour period (additively manufacture a titanium-based antibiotic eluting implant, which is an attractive alternative to current treatment strategies of periprosthetic infections. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Inflammatory mediators in a short-time mouse model of doxorubicin-induced cardiotoxicity

    Energy Technology Data Exchange (ETDEWEB)

    Pecoraro, Michela; Del Pizzo, Mariagiovanna; Marzocco, Stefania; Sorrentino, Rosalinda [Department of Pharmacy, University of Salerno, Fisciano, SA (Italy); Ciccarelli, Michele; Iaccarino, Guido [Department of Medicine and Surgery, University of Salerno, Baronissi, SA (Italy); Pinto, Aldo [Department of Pharmacy, University of Salerno, Fisciano, SA (Italy); Popolo, Ada, E-mail: apopolo@unisa.it [Department of Pharmacy, University of Salerno, Fisciano, SA (Italy)

    2016-02-15

    Doxorubicin (DOXO) is commonly used to treat a wide range of malignant tumors, but its clinical use is limited by acute and chronic cardiotoxicity. The precise mechanism underlying DOXO-induced cardiotoxicity is still not completely elucidated, but cardiac inflammation seems to be involved. Effects of DOXO on proinflammatory cytokines, inflammatory cell infiltration, and necrosis have been proven only when a functional impairment has already occurred, so this study aimed to investigate the acute effect of DOXO administration in mouse heart. The results of our study demonstrated alterations in cardiac function parameters assessed by ultrasound within 24 h after a single injection of DOXO, with a cumulative effect along the increase of the dose and the number of DOXO administrations. At the same time, DOXO causes a significant production of proinflammatory cytokines (such as TNF-α and IL-6) with a concomitant reduction of IL-10, a well-known antiinflammatory cytokine. Furthermore, overexpression of inducible nitric oxide synthase (iNOS) in heart tissue and increased levels of serum nitrite in DOXO-treated mice were detected. Notably, DOXO administration significantly increased nitrotyrosine expression in mouse heart. Our data support the hypothesis that these early events, could be responsible for the later onset of more severe deleterious remodeling leading to DOXO induced cardiomyopathy. - Highlights: • Doxorubicin induces echocardiographic alterations of the main cardiac functional parameters. • Doxorubicin induces increase of TNF-α and IL-6 production and iNOS expression. • Doxorubicin causes a significant reduction of the antiinflammatory cytokine IL-10. • The doses are lower than that used in human. • Doxorubicin administration significantly increased nitrotyrosine expression.

  5. Short-time scale coupling between thermohaline and meteorological forcing in the Ría de Pontevedra

    Directory of Open Access Journals (Sweden)

    Paula C. Pardo

    2001-07-01

    Full Text Available Two cruises were performed in May-June and October-November 1997 in the Ría de Pontevedra under strong downwelling conditions. Temperature and salinity data were recorded in short sampling periods to describe the changes in thermohaline property distribution in a short time scale. In order to obtain the residual fluxes in the Ría, a bi-dimensional non-stationary salt and thermal-energy weight averaged box-model was applied. Outputs from this kinematic model were compared with Upwelling Index, river flow and density gradient, resulting in a good multiple correlation, which proves the strong coupling between thermohaline properties and meteorological variability. Ekman forcing affects the whole area but mainly controls the dynamics of outer zones. The intensity of its effect on the circulation pattern within the Ría depends on the grade of stratification of the water bodies. River flow is more relevant in inner parts. According to estimated spatially averaged velocities, water residence time is lower than two weeks in outer parts of the Ría, and decreases toward the inner zones.

  6. Effectiveness of Combined Tear Film Therapy in Patients with Evaporative Dry Eye with Short Tear Film Breakup Time.

    Science.gov (United States)

    Kim, Yung Hui; Kang, Yeon Soo; Lee, Hyo Seok; Choi, Won; You, In Cheon; Yoon, Kyung Chul

    2017-10-01

    The aim of this study was to evaluate the effectiveness of combined tear film therapy targeted to aqueous, mucin, and lipid layers in patients with refractory evaporative dry eye (EDE) with short tear film breakup time (TBUT). The patients who had EDE with short TBUT and severe symptoms refractory to artificial tears were treated with hyaluronic acid (HA) 0.15% and diquafosol tetrasodium (DQS) 3% (Group 1), HA and carbomer-based lipid-containing eyedrops (Liposic EDO Gel, LPO) (Group 2), or HA, DQS, and LPO (Group 3). Ocular Surface Disease Index (OSDI) score, visual analog scale (VAS) symptom score, TBUT, Schirmer score, and corneal and conjunctival staining scores were evaluated, and noninvasive tear film breakup time (NIBUT) and tear meniscus height were measured using Keratograph ® 5 M before and 1 and 3 months after treatment. OSDI scores, VAS scores, TBUT, and NIBUT were improved at 1 and 3 months after treatment in all groups (all P film layers was most effective in improving ocular symptoms and tear film quality.

  7. The use of short-echo-time 1H MRS for childhood cerebellar tumours prior to histopathological diagnosis

    International Nuclear Information System (INIS)

    Harris, Lisa M.; Peet, Andrew C.; Davies, Nigel; Natarajan, Kal; MacPherson, Lesley; Foster, Katharine; Lateef, Shaheen; Sgouros, Spyridon; Brundler, Marie-Anne; Arvanitis, Theodoros N.; Grundy, Richard G.

    2007-01-01

    Proton magnetic resonance spectroscopy (MRS) measures concentrations of metabolites in vivo and provides a powerful method for identifying tumours. MRS has not entered routine clinical use partly due to the difficulty of analysing the spectra. To create a straightforward method for interpreting short-echo-time MRS of childhood cerebellar tumours. Single-voxel MRS (1.5-T Siemens Symphony NUM4, TR/TE 1,500/30 ms) was performed at presentation in 30 children with cerebellar tumours. The MRS results were analysed for comparison with histological diagnosis. Peak heights for N-acetyl aspartate (NAA), creatine (Cr), choline (Cho) and myo-inositol (mIns) were determined and receiver operator characteristic curves used to select ratios that best discriminated between the tumour types. The method was implemented by a group of clinicians and scientists, blinded to the results. A total of 27 MRS studies met the quality control criteria. NAA/Cr >4.0 distinguished all but one of the astrocytomas from the other tumours. A combination of Cr/Cho <0.75 and mIns/NAA <2.1 separated all the medulloblastomas from the ependymomas. Peak height ratios from short-echo-time MRS can accurately predict the histopathology of childhood cerebellar tumours. (orig.)

  8. The impact of short night-time naps on performance, sleepiness and mood during a simulated night shift.

    Science.gov (United States)

    Centofanti, Stephanie A; Hilditch, Cassie J; Dorrian, Jillian; Banks, Siobhan

    2016-01-01

    Short naps on night shift are recommended in some industries. There is a paucity of evidence to verify the sustained recovery benefits of short naps in the last few hours of the night shift. Therefore, the current study aimed to investigate the sustained recovery benefits of 30 and 10-min nap opportunities during a simulated night shift. Thirty-one healthy participants (18F, 21-35 y) completed a 3-day, between-groups laboratory study with one baseline night (22:00-07:00 h time in bed), followed by one night awake (time awake from 07:00 h on day two through 10:00 h day three) with random allocation to: a 10-min nap opportunity ending at 04:00 h, a 30-min nap opportunity ending at 04:00 h or no nap (control). A neurobehavioral test bout was administered approximately every 2 h during wake periods. There were no significant differences between nap conditions for post-nap psychomotor vigilance performance after controlling for pre-nap scores (p > 0.05). The 30-min nap significantly improved subjective sleepiness compared to the 10-min nap and no-nap control (p effect.

  9. Does Occupational Exposure of Shahid Dastghieb International Airport Workers to Radiofrequency Radiation Affect Their Short Term Memory and Reaction Time?

    Directory of Open Access Journals (Sweden)

    Jarideh S.

    2015-05-01

    Full Text Available Background: Airport workers are continuously exposed to different levels of radiofrequency microwave (RF/MW radiation emitted by radar equipments. Radars are extensively used in military and aviation industries. Over the past several years, our lab has focused on the health effects of exposure to different sources of electromagnetic fields such as cellular phones, mobile base stations, mobile phone jammers, laptop computers, radars, dentistry cavitrons and MRI. The main goal of this study was to investigate if occupational exposure of Shahid Dastghieb international airport workers to radiofrequency radiation affects their short term memory and reaction time. Methods: Thirty two airport workers involved in duties at control and approach tower (21 males and 11 females, with the age range of 27-67 years old (mean age of 37.38, participated voluntary in this study. On the other hand, 29 workers (13 males, and 16 females whose offices were in the city with no exposure history to radar systems were also participated in this study as the control group. The employees’ reaction time and short term memory were analyzed using a standard visual reaction time (VRT test software and the modified Wechsler memory scale test, respectively. Results: The mean± SD values for the reaction times of the airport employees (N=32 and the control group (N=29 were 0.45±0.12 sec and 0.46±0.17 sec, respectively. Moreover, in the four subset tests; i.e. paired words, forward digit span, backward digit span and word recognition, the following points were obtained for the airport employees and the control group, respectively: (i pair words test: 28.00±13.13 and 32.07±11.65, (ii forward digit span: 8.38±1.40 and 9.03±1.32, (iii backward digit span: 5.54±1.87 and 6.31±1.46, and (iv word recognition: 5.73±2.36 and 6.50±1.93. These differences were not statistically significant. Conclusion: The occupational exposure of the employees to the RF radiation in Shahid

  10. Retention prediction and separation optimization under multilinear gradient elution in liquid chromatography with Microsoft Excel macros.

    Science.gov (United States)

    Fasoula, S; Zisi, Ch; Gika, H; Pappa-Louisi, A; Nikitas, P

    2015-05-22

    A package of Excel VBA macros have been developed for modeling multilinear gradient retention data obtained in single or double gradient elution mode by changing organic modifier(s) content and/or eluent pH. For this purpose, ten chromatographic models were used and four methods were adopted for their application. The methods were based on (a) the analytical expression of the retention time, provided that this expression is available, (b) the retention times estimated using the Nikitas-Pappa approach, (c) the stepwise approximation, and (d) a simple numerical approximation involving the trapezoid rule for integration of the fundamental equation for gradient elution. For all these methods, Excel VBA macros have been written and implemented using two different platforms; the fitting and the optimization platform. The fitting platform calculates not only the adjustable parameters of the chromatographic models, but also the significance of these parameters and furthermore predicts the analyte elution times. The optimization platform determines the gradient conditions that lead to the optimum separation of a mixture of analytes by using the Solver evolutionary mode, provided that proper constraints are set in order to obtain the optimum gradient profile in the minimum gradient time. The performance of the two platforms was tested using experimental and artificial data. It was found that using the proposed spreadsheets, fitting, prediction, and optimization can be performed easily and effectively under all conditions. Overall, the best performance is exhibited by the analytical and Nikitas-Pappa's methods, although the former cannot be used under all circumstances. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. A deep learning framework for financial time series using stacked autoencoders and long-short term memory.

    Science.gov (United States)

    Bao, Wei; Yue, Jun; Rao, Yulei

    2017-01-01

    The application of deep learning approaches to finance has received a great deal of attention from both investors and researchers. This study presents a novel deep learning framework where wavelet transforms (WT), stacked autoencoders (SAEs) and long-short term memory (LSTM) are combined for stock price forecasting. The SAEs for hierarchically extracted deep features is introduced into stock price forecasting for the first time. The deep learning framework comprises three stages. First, the stock price time series is decomposed by WT to eliminate noise. Second, SAEs is applied to generate deep high-level features for predicting the stock price. Third, high-level denoising features are fed into LSTM to forecast the next day's closing price. Six market indices and their corresponding index futures are chosen to examine the performance of the proposed model. Results show that the proposed model outperforms other similar models in both predictive accuracy and profitability performance.

  12. Shorting time of magnetically insulated reflex-ion diodes from the neutral-atom charge-exchange mechanism

    International Nuclear Information System (INIS)

    Strobel, G.

    1981-10-01

    In a magnetically insulated diode, collision-free electrons return to the cathode and no electron current is present at the anode. Electron transport to the anode is studied in this paper. Steady-state space-charge-limited flow is assumed initially. Breakdown of ion flow occurs when static neutral atoms at the anode undergo charge exchange, which results in neutral atoms drifting across the diode. These are subsequently ionized by reflexing ions producing electrons trapped in Larmor orbits throughout the diode. These electrons drift to the anode via ionization and inelastic collisions with other neutral atoms. Model calculations compare the effects of foil and mesh cathodes. Steady-state space-charge-limited ion current densities are calculated. The neutral atom density at the cathode is determined as a function of time. The shorting time of the diode is scaled versus the electrode separation d, the diode potential V 0 , the magnetic field, and the initial concentration of static neutron atoms

  13. A deep learning framework for financial time series using stacked autoencoders and long-short term memory

    Science.gov (United States)

    Bao, Wei; Rao, Yulei

    2017-01-01

    The application of deep learning approaches to finance has received a great deal of attention from both investors and researchers. This study presents a novel deep learning framework where wavelet transforms (WT), stacked autoencoders (SAEs) and long-short term memory (LSTM) are combined for stock price forecasting. The SAEs for hierarchically extracted deep features is introduced into stock price forecasting for the first time. The deep learning framework comprises three stages. First, the stock price time series is decomposed by WT to eliminate noise. Second, SAEs is applied to generate deep high-level features for predicting the stock price. Third, high-level denoising features are fed into LSTM to forecast the next day’s closing price. Six market indices and their corresponding index futures are chosen to examine the performance of the proposed model. Results show that the proposed model outperforms other similar models in both predictive accuracy and profitability performance. PMID:28708865

  14. Prediction of long time creep rupture properties of welded joints using the results of short duration creep crack incubation tests

    Energy Technology Data Exchange (ETDEWEB)

    Hosseini, E.

    2013-07-01

    This dissertation submitted to the Swiss Federal Institute of Technology ETH in Zurich examines the applicability of the LICON methodology for the prediction of long-time creep rupture strength of a dissimilar metal weld. The LICON methodology is an approach for predicting the lifetime of materials under creep loading conditions. It predicts long-time uniaxial creep strength using the results from several short duration creep crack incubation tests in conjunction with the outcome of a mechanical analysis on the test-piece. This study has re-examined the previous application of the LICON methodology for 9%Cr and 1CrMoV steels. It has shown that application of the original Lion method (based on reference stress solutions) for certain materials is not appropriate. This study therefore proposes a new development for the Lion approach which uses finite-element analysis to account for the generated multiaxial stress states within welded uniaxial test-pieces.

  15. Short-Term Forecasting of Urban Storm Water Runoff in Real-Time using Extrapolated Radar Rainfall Data

    DEFF Research Database (Denmark)

    Thorndahl, Søren Liedtke; Rasmussen, Michael R.

    2013-01-01

    Model based short-term forecasting of urban storm water runoff can be applied in realtime control of drainage systems in order to optimize system capacity during rain and minimize combined sewer overflows, improve wastewater treatment or activate alarms if local flooding is impending. A novel onl....... The radar rainfall extrapolation (nowcast) limits the lead time of the system to two hours. In this paper, the model set-up is tested on a small urban catchment for a period of 1.5 years. The 50 largest events are presented....... online system, which forecasts flows and water levels in real-time with inputs from extrapolated radar rainfall data, has been developed. The fully distributed urban drainage model includes auto-calibration using online in-sewer measurements which is seen to improve forecast skills significantly...

  16. Prediction of long time creep rupture properties of welded joints using the results of short duration creep crack incubation tests

    International Nuclear Information System (INIS)

    Hosseini, E.

    2013-01-01

    This dissertation submitted to the Swiss Federal Institute of Technology ETH in Zurich examines the applicability of the LICON methodology for the prediction of long-time creep rupture strength of a dissimilar metal weld. The LICON methodology is an approach for predicting the lifetime of materials under creep loading conditions. It predicts long-time uniaxial creep strength using the results from several short duration creep crack incubation tests in conjunction with the outcome of a mechanical analysis on the test-piece. This study has re-examined the previous application of the LICON methodology for 9%Cr and 1CrMoV steels. It has shown that application of the original Lion method (based on reference stress solutions) for certain materials is not appropriate. This study therefore proposes a new development for the Lion approach which uses finite-element analysis to account for the generated multiaxial stress states within welded uniaxial test-pieces

  17. Time-separated oscillatory fields for high-precision mass measurements on short-lived Al and Ca nuclides

    CERN Document Server

    George, Simon; Blank, B.; Blaum, K.; Breitenfeldt, M.; Hager, U.; Herfurth, F.; Herlert, A.; Kellerbauer, A.; Kluge, H.J.; Kretzschmar, M.; Lunney, D.; Savreux, R.; Schwarz, Andreas S.; Schweikhard, L.; Yazidjian, C.

    2008-01-01

    High-precision Penning trap mass measurements on the stable nuclide $^{27}$Al as well as on the short-lived radionuclides $^{26}$Al and $^{38,39}$Ca have been performed by use of radio-frequency excitation with time-separated oscillatory fields, i.e. Ramsey's method, as recently introduced for the excitation of the ion motion in a Penning trap, was applied. A comparison with the conventional method of a single continuous excitation demonstrates its advantage of up to ten times shorter measurements. The new mass values of $^{26,27}$Al clarify conflicting data in this specific mass region. In addition, the resulting mass values of the superallowed $\\beta$-emitter $^{38}$Ca as well as of the groundstate of the $\\beta$-emitter $^{26}$Al$^{m}$ confirm previous measurements and corresponding theoretical corrections of the ft-values.

  18. A deep learning framework for financial time series using stacked autoencoders and long-short term memory.

    Directory of Open Access Journals (Sweden)

    Wei Bao

    Full Text Available The application of deep learning approaches to finance has received a great deal of attention from both investors and researchers. This study presents a novel deep learning framework where wavelet transforms (WT, stacked autoencoders (SAEs and long-short term memory (LSTM are combined for stock price forecasting. The SAEs for hierarchically extracted deep features is introduced into stock price forecasting for the first time. The deep learning framework comprises three stages. First, the stock price time series is decomposed by WT to eliminate noise. Second, SAEs is applied to generate deep high-level features for predicting the stock price. Third, high-level denoising features are fed into LSTM to forecast the next day's closing price. Six market indices and their corresponding index futures are chosen to examine the performance of the proposed model. Results show that the proposed model outperforms other similar models in both predictive accuracy and profitability performance.

  19. First Isochronous Time-of-Flight Mass Measurements of Short-Lived Projectile Fragments in the ESR

    International Nuclear Information System (INIS)

    Stadlmann, J.; Geissel, H.; Hausmann, M.; Nolden, F.; Radon, T.; Schatz, H.; Scheidenberger, C.; Attallah, F.; Beckert, K.; Bosch, F.; Falch, M.; Franczak, B.; Franzke, B.; Kerscher, Th.; Klepper, O.; Kluge, H.J.; Kozhuharov, C.; Loebner, K.E.G.; Muenzenberg, G.; Novikov, Yu.N.; Steck, M.; Sun, Z.; Suemmerer, K.; Weick, H.; Wollnik, H.

    2000-01-01

    A new method for precise mass measurements of short-lived hot nuclei is presented. These nuclei were produced via projectile fragmentation, separated with the FRS and injected into the storage ring ESR being operated in the isochronous mode. The revolution time of the ions is measured with a time-of-flight detector sensitive to single particles. This new method allows access to exotic nuclei with half-lives in the microsecond region. First results from this novel method obtained with measurements on neutron-deficient fragments of a chromium primary beam with half-lives down to 50 ms are reported. A precision of deltam/m ≤ 5 · 10 -6 has been achieved

  20. A prospective, randomized evaluation of a novel everolimus-eluting coronary stent

    DEFF Research Database (Denmark)

    Stone, Gregg W; Teirstein, Paul S; Meredith, Ian T

    2011-01-01

    We sought to evaluate the clinical outcomes with a novel platinum chromium everolimus-eluting stent (PtCr-EES) compared with a predicate cobalt chromium everolimus-eluting stent (CoCr-EES) in patients undergoing percutaneous coronary intervention (PCI).......We sought to evaluate the clinical outcomes with a novel platinum chromium everolimus-eluting stent (PtCr-EES) compared with a predicate cobalt chromium everolimus-eluting stent (CoCr-EES) in patients undergoing percutaneous coronary intervention (PCI)....

  1. Comparison of clinical outcomes after drug-eluting balloon and drug-eluting stent use for in-stent restenosis related acute myocardial infarction: a retrospective study

    Directory of Open Access Journals (Sweden)

    Chih-Yuan Fang

    2018-04-01

    Full Text Available Background Good results of drug-eluting balloon (DEB use are achieved in in-stent restenosis (ISR lesions, small vessel disease, long lesions, and bifurcations. However, few reports exist about DEB use in acute myocardial infarction (AMI with ISR. This study’s aim was to evaluate the efficacy of DEB for AMI with ISR. Methods Between November 2011 and December 2015, 117 consecutive patients experienced AMI including ST-segment elevation MI, and non-ST-segment elevation MI due to ISR, and received percutaneous coronary intervention (PCI. We divided our patients into two groups: (1 PCI with further DEB, and (2 PCI with further drug-eluting stent (DES. Clinical outcomes such as target lesion revascularization, target vessel revascularization, recurrent MI, stroke, cardiovascular mortality, and all-cause mortality were analyzed. Results The patients’ average age was 68.37 ± 11.41 years; 69.2% were male. A total of 75 patients were enrolled in the DEB group, and 42 patients were enrolled in the DES group. The baseline characteristics between the two groups were the same without statistical differences except for gender. Peak levels of cardiac biomarker, pre- and post-PCI cardiac function were similar between two groups. The major adverse cardiac cerebral events rate (34.0% vs. 35.7%; p = 0.688 and cardiovascular mortality rate (11.7% vs. 12.8%; p = 1.000 were similar in both groups. Conclusions DEB is a reasonable strategy for AMI with ISR. Compared with DES, DEB is an alternative strategy which yielded acceptable short-term outcomes and similar 1-year clinical outcomes.

  2. From drug eluting stents to bioresorbable scaffolds; to new horizons in PCI

    NARCIS (Netherlands)

    Tenekecioglu, Erhan; Bourantas, Christos; Abdelghani, Mohammad; Zeng, Yaping; Silva, Rafael Cavalcante; Tateishi, Hiroki; Sotomi, Yohei; Onuma, Yoshinobu; Yılmaz, Mustafa; Serruys, Patrick W.

    2016-01-01

    Drug eluting stents and particularly the fully bioresorbable drug-eluting scaffolds herald a new era in percutaneous treatment of coronary artery disease. There has been tremendous progress in drug eluting stents with fully biodegradable coating polymers and polymer-free devices with reservoir

  3. Comparison of Durable-Polymer Zotarolimus-Eluting and Biodegradable-Polymer Biolimus-Eluting Coronary Stents in Patients With Coronary Artery Disease

    DEFF Research Database (Denmark)

    Raungaard, Bent; Christiansen, Evald H; Bøtker, Hans Erik

    2017-01-01

    artery disease or acute coronary syndromes and at least 1 coronary artery lesion requiring treatment with a drug-eluting stent. Endpoints included major adverse cardiac events (MACE), a composite of safety (cardiac death and myocardial infarction not clearly attributable to a non-target lesion......OBJECTIVES: The authors sought to compare the safety and efficacy of the biocompatible durable-polymer zotarolimus-eluting stent with the biodegradable-polymer biolimus-eluting stent in unselected coronary patients. BACKGROUND: Biodegradable-polymer biolimus-eluting stents are superior to first......-generation durable-polymer drug-eluting stents in long-term randomized all-comer trials. Long-term data comparing them to second-generation durable-polymer drug-eluting stents are lacking. METHODS: The study was a randomized, multicenter, all-comer, noninferiority trial in patients with chronic stable coronary...

  4. Time-dependent H-like and He-like Al lines produced by ultra-short pulse laser

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Takako; Kato, Masatoshi [National Inst. for Fusion Science, Nagoya (Japan); Shepherd, R; Young, B; More, R; Osterheld, Al

    1998-03-01

    We have performed numerical modeling of time-resolved x-ray spectra from thin foil targets heated by the LLNL Ultra-short pulse (USP) laser. The targets were aluminum foils of thickness ranging from 250 A to 1250 A, heated with 120 fsec pulses of 400 nm light from the USP laser. The laser energy was approximately 0.2 Joules, focused to a 3 micron spot size for a peak intensity near 2 x 10{sup 19} W/cm{sup 2}. Ly{alpha} and He{alpha} lines were recorded using a 900 fsec x-ray streak camera. We calculate the effective ionization, recombination and emission rate coefficients including density effects for H-like and He-like aluminum ions using a collisional radiative model. We calculate time-dependent ion abundances using these effective ionization and recombination rate coefficients. The time-dependent electron temperature and density used in the calculation are based on an analytical model for the hydrodynamic expansion of the target foils. During the laser pulse the target is ionized. After the laser heating stops, the plasma begins to recombine. Using the calculated time dependent ion abundances and the effective emission rate coefficients, we calculate the time dependent Ly{alpha} and He{alpha} lines. The calculations reproduce the main qualitative features of the experimental spectra. (author)

  5. Determination of 99Mo contamination in 99mTc elute obtained from 99Mo/99mTc- generator

    International Nuclear Information System (INIS)

    Momennezhad, M.; Zakavi, S. R.; Sadeghi, R.

    2010-01-01

    99m Tc is a widely used radioisotope in nuclear medicine centers which is obtained by elution from Mo-99/Tc-99m generators. Usually the generators are either supplied by the Iran Atomic Energy Agency or by private companies from foreign countries. In this study we have measured 99 Mo contamination in 99m Tc elute from different generators in a period of one year. Materials and Methods: The radionuclide impurity of the 99m Tc elute were studied in two types of radionuclide generators (A: produced in Iran and B: Imported from other country). In-vitro measurements were performed using dose calibrator. Direct measurements were made, using a standard canister at the time of milking of the generators and also in Subsequent hours after milking. Results: The results showed a mean of 99 Mo impurity in generators A and B to be 0.00932±0.0043 and 0.0170±0.0127 respectively. Although the results showed that the 99 Mo contamination in 99 mTc elute was lesser than the maximum accepted activity limit of 0.015%, the difference in these two types may reflect different methods of productions of generator, as well as the quality control procedures. Conclusion: The mean of 99 Mo contamination in generators produced in Iran Atomic Energy Organization was lesser than generators imported from foreign origin.

  6. X-ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elution

    Energy Technology Data Exchange (ETDEWEB)

    Bradley, M O; Kohn, K W [National Institutes of Health, Bethesda, MD (USA)

    1979-10-01

    A neutral filter elution method was used for detecting DNA double strand breaks in mouse L1210 cells after X-ray. The assay detected the number of double strand breaks induced by as little as 1000 rad of X-ray. The rate of DNA elution through the filters under neutral conditions increased with X-ray dose. Certain conditions for deproteinization, pH, and filter type were shown to increase the assay's sensitivity. Hydrogen peroxide and Bleomycin also induced apparent DNA double strand breaks, although the ratios of double to single strand breaks varied from those produced by X-ray. The introduction of double strand cuts by HpA I restriction endonuclease in DNA lysed on filters resulted in a rapid rate of elution under neutral conditions, implying that the method can detect double strand breaks if they exist in the DNA. The eluted DNA banded with a double stranded DNA marker in cesium chloride. This evidence suggested that the assay detected DNA double strand breaks. L1210 cells were shown to rejoin most of the DNA double strand breaks induced by 5-10 krad of X-ray with a half-time of about 40 minutes. (author).

  7. Short communication

    African Journals Online (AJOL)

    abp

    2017-09-04

    Sep 4, 2017 ... Face-to-face interviews were conducted using a standardized ... Short communication. Open Access ... clinic during the time of the study and were invited to participate in the study. .... consume them. This is another ...

  8. Non-linear dynamical classification of short time series of the rössler system in high noise regimes.

    Science.gov (United States)

    Lainscsek, Claudia; Weyhenmeyer, Jonathan; Hernandez, Manuel E; Poizner, Howard; Sejnowski, Terrence J

    2013-01-01

    Time series analysis with delay differential equations (DDEs) reveals non-linear properties of the underlying dynamical system and can serve as a non-linear time-domain classification tool. Here global DDE models were used to analyze short segments of simulated time series from a known dynamical system, the Rössler system, in high noise regimes. In a companion paper, we apply the DDE model developed here to classify short segments of encephalographic (EEG) data recorded from patients with Parkinson's disease and healthy subjects. Nine simulated subjects in each of two distinct classes were generated by varying the bifurcation parameter b and keeping the other two parameters (a and c) of the Rössler system fixed. All choices of b were in the chaotic parameter range. We diluted the simulated data using white noise ranging from 10 to -30 dB signal-to-noise ratios (SNR). Structure selection was supervised by selecting the number of terms, delays, and order of non-linearity of the model DDE model that best linearly separated the two classes of data. The distances d from the linear dividing hyperplane was then used to assess the classification performance by computing the area A' under the ROC curve. The selected model was tested on untrained data using repeated random sub-sampling validation. DDEs were able to accurately distinguish the two dynamical conditions, and moreover, to quantify the changes in the dynamics. There was a significant correlation between the dynamical bifurcation parameter b of the simulated data and the classification parameter d from our analysis. This correlation still held for new simulated subjects with new dynamical parameters selected from each of the two dynamical regimes. Furthermore, the correlation was robust to added noise, being significant even when the noise was greater than the signal. We conclude that DDE models may be used as a generalizable and reliable classification tool for even small segments of noisy data.

  9. Differential clinical outcomes after 1 year versus 5 years in a randomised comparison of zotarolimus-eluting and sirolimus-eluting coronary stents (the SORT OUT III study)

    DEFF Research Database (Denmark)

    Maeng, Michael; Tilsted, Hans Henrik; Jensen, Lisette Okkels

    2014-01-01

    received two different types of drug-eluting stents. METHODS: We undertook this multicentre, open-label, randomised superiority trial at five percutaneous coronary intervention centres in Denmark. We randomly allocated 2332 eligible adult patients (≥18 years of age) with an indication for drug......-eluting stent implantation to the zotarolimus-eluting Endeavor Sprint stent (Medtronic, Santa Rosa, CA, USA) or the sirolimus-eluting Cypher Select Plus stent (Cordis, Johnson & Johnson, Warren, NJ, USA). Randomisation of participants was achieved by computer-generated block randomisation and a telephone...

  10. Sistem kontrol inventori pemasokan barang Secara Real Time Menggunakan Vendor-Managed Inventory (VMI dan Short Message Service (SMS

    Directory of Open Access Journals (Sweden)

    Rinaldo Turang

    2016-01-01

    Full Text Available This research underlines the urgency of real-time stock replenishment control system for distributors using vendor-managed inventory. It is valuable in improving corporate performance in lowering inventory cost as well as making better customer service due to the cut made in ordering cycle. The system produces real-time information on stock available at the retailing stores. Stock replenishment can then be done by the distributor at the right time. Using Short Message Service (SMS as a one-way information channel from retailers to their distributor, the data of every transaction of the supervised item are processed by a rule-based forward-chaining inference system to determine the item’s availability in stores. Folowing steps in Rapid Application Development (RAD, the construction of this system takes place through business modeling, data modeling, process modeling of VMI system, then the application is generated and tested as a prototype. The results are: the stock replenishment control system are able to make transactional data at the stores transparent to the distributor, facilitating the continuation in stock delivery. System architecture reduces the time needed to access information about sales on supervised item by using SMS shortcut. This control system developed in stores can be operationally independent from the retailing systems. Rule-based forward-chaining inference technique processes facts on stock variations, resulting in stock replenishment notification such as normal, reserve, and depleted warning. Keywords: VMI, inventory; Stock replenishment; Rule-based reasoning; Forward-chaining system, RAD

  11. Effect of high-temperature, short-time (HTST) pasteurization on milk containing low numbers of Mycobacterium paratuberculosis.

    Science.gov (United States)

    Grant, I R; Ball, H J; Rowe, M T

    1998-02-01

    The efficacy of high-temperature, short-time (HTST) pasteurization (72 degrees C/15 s) when low numbers (HTST pasteurization using laboratory pasteurizing units. Ten bovine strains of Myco. paratuberculosis were tested in triplicate. Culture in BACTEC Middlebrook 12B radiometric medium detected acid-fast survivors in 14.8% and 10% of HTST-pasteurized milk samples at the 10(3) and 10(2) cfu ml-1 inoculum levels, respectively, whereas conventional culture on Herrold's egg yolk medium containing mycobactin J detected acid-fast survivors in only 3.7% and 6.7% of the same milk samples. IS900-based PCR confirmed that these acid-fast survivors were Myco. paratuberculosis. No viable Myco. paratuberculosis were isolated from HTST-pasteurized milk initially containing either 10 cfu ml-1 or 10 cfu 50 ml-1.

  12. Short-time fourth-order squeezing effects in spontaneous and stimulated four- and six-wave mixing processes

    International Nuclear Information System (INIS)

    Giri, Dilip Kumar; Gupta, P S

    2003-01-01

    The concept of fourth-order squeezing of the electromagnetic field is investigated in the fundamental mode in spontaneous and stimulated four- and six-wave mixing processes under the short-time approximation based on a fully quantum mechanical approach. The coupled Heisenberg equations of motion involving real and imaginary parts of the quadrature operators are established. The possibility of obtaining fourth-order squeezing is studied. The dependence of fourth-order squeezing on the number of photons is also investigated. It is shown that fourth-order squeezing, which is a higher-order squeezing, allows a much larger fractional noise reduction than lower-order squeezing. It is shown that squeezing is greater in a stimulated process than the corresponding squeezing in spontaneous interaction. The conditions for obtaining maximum and minimum squeezing are obtained. We have also established the non-classical nature of squeezed radiation using the Glauber-Sudarshan representation

  13. Analyses of kinetic glass transition in short-range attractive colloids based on time-convolutionless mode-coupling theory.

    Science.gov (United States)

    Narumi, Takayuki; Tokuyama, Michio

    2017-03-01

    For short-range attractive colloids, the phase diagram of the kinetic glass transition is studied by time-convolutionless mode-coupling theory (TMCT). Using numerical calculations, TMCT is shown to recover all the remarkable features predicted by the mode-coupling theory for attractive colloids: the glass-liquid-glass reentrant, the glass-glass transition, and the higher-order singularities. It is also demonstrated through the comparisons with the results of molecular dynamics for the binary attractive colloids that TMCT improves the critical values of the volume fraction. In addition, a schematic model of three control parameters is investigated analytically. It is thus confirmed that TMCT can describe the glass-glass transition and higher-order singularities even in such a schematic model.

  14. A voxel-based investigation for MRI-only radiotherapy of the brain using ultra short echo times

    DEFF Research Database (Denmark)

    Edmund, Jens Morgenthaler; Kjer, Hans Martin; Van Leemput, Koen

    2014-01-01

    including or excluding additional spatial information. Approach 3 used a statistical regression correlating MRI voxels with their corresponding CT voxels. A similar photon and proton treatment plan was generated for a target positioned between the nasal cavity and the brainstem for all patients. The CT...... receiving cranial irradiation, each containing a co-registered MRI and CT scan, were included. An ultra short echo time MRI sequence for bone visualization was used. Six methods were investigated for three popular types of voxel-based approaches; (1) threshold-based segmentation, (2) Bayesian segmentation...... significantly better than the threshold and Bayesian segmentation methods (excluding spatial information). All methods agreed significantly better with CT than a reference water MRI comparison. The mean dosimetric deviation for photons and protons compared to the CT was about 2% and highest in the gradient dose...

  15. Implementing high-temperature short-time media treatment in commercial-scale cell culture manufacturing processes.

    Science.gov (United States)

    Pohlscheidt, Michael; Charaniya, Salim; Kulenovic, Fikret; Corrales, Mahalia; Shiratori, Masaru; Bourret, Justin; Meier, Steven; Fallon, Eric; Kiss, Robert

    2014-04-01

    The production of therapeutic proteins by mammalian cell culture is complex and sets high requirements for process, facility, and equipment design, as well as rigorous regulatory and quality standards. One particular point of concern and significant risk to supply chain is the susceptibility to contamination such as bacteria, fungi, mycoplasma, and viruses. Several technologies have been developed to create barriers for these agents to enter the process, e.g. filtration, UV inactivation, and temperature inactivation. However, if not implemented during development of the manufacturing process, these types of process changes can have significant impact on process performance if not managed appropriately. This article describes the implementation of the high-temperature short-time (HTST) treatment of cell culture media as an additional safety barrier against adventitious agents during the transfer of a large-scale commercial cell culture manufacturing process. The necessary steps and experiments, as well as subsequent results during qualification runs and routine manufacturing, are shown.

  16. Improving Thin Bed Identification in Sarawak Basin Field using Short Time Fourier Transform Half Cepstrum (STFTHC) method

    Science.gov (United States)

    Nizarul, O.; Hermana, M.; Bashir, Y.; Ghosh, D. P.

    2016-02-01

    In delineating complex subsurface geological feature, broad band of frequencies are needed to unveil the often hidden features of hydrocarbon basin such as thin bedding. The ability to resolve thin geological horizon on seismic data is recognized to be a fundamental importance for hydrocarbon exploration, seismic interpretation and reserve prediction. For thin bedding, high frequency content is needed to enable tuning, which can be done by applying the band width extension technique. This paper shows an application of Short Time Fourier Transform Half Cepstrum (STFTHC) method, a frequency bandwidth expansion technique for non-stationary seismic signal in increasing the temporal resolution to uncover thin beds and improve characterization of the basin. A wedge model and synthetic seismic data is used to quantify the algorithm as well as real data from Sarawak basin were used to show the effectiveness of this method in enhancing the resolution.

  17. Fetal short time variation during labor: a non-invasive alternative to fetal scalp pH measurements?

    Science.gov (United States)

    Schiermeier, Sven; Reinhard, Joscha; Hatzmann, Hendrike; Zimmermann, Ralf C; Westhof, Gregor

    2009-01-01

    To determine whether short time variation (STV) of fetal heart beat correlates with scalp pH measurements during labor. From 1279 deliveries, 197 women had at least one fetal scalp pH measurement. Using the CTG-Player, STVs were calculated from the electronically saved cardiotocography (CTG) traces and related to the fetal scalp pH measurements. There was no correlation between STV and fetal scalp pH measurements (r=-0.0592). Fetal STV is an important parameter with high sensitivity for antenatal fetal acidosis. This study shows that STV calculations do not correlate with fetal scalp pH measurements during labor, hence are not helpful in identifying fetal acidosis.

  18. Experience from transportation of irradiated WWER-440 fuel assemblies at Kozloduy NPP site after a short cooling time

    International Nuclear Information System (INIS)

    Stoyanova, I.; Kamenov, A.; Byrzev, L.; Christoskov, I.

    2003-01-01

    The presented results from the computation and analysis of the radiation characteristics of the irradiated fuel assemblies by the date of their transportation according to the selected loading patterns of the VSPOT cask and following the modified technology of transportation, i.e. without replacement of the pool solution by pure condensate, as well as the corresponding experimental results, confirm the applicability of the newly introduced safety criterion for the selection of a loading pattern of the cask with irradiated fuel assemblies after a short cooling time. The comparison between measured and computed surface dose rates shows that during the procedure of transfer of irradiated fuel assemblies from the pools of Units 1 and 2 to the pools of Kozloduy NPP Units 3 and 4 all safety limits, incl. the radiation protection requirements, were met

  19. A Distributed Web-based Solution for Ionospheric Model Real-time Management, Monitoring, and Short-term Prediction

    Science.gov (United States)

    Kulchitsky, A.; Maurits, S.; Watkins, B.

    2006-12-01

    provide inputs for the next ionospheic model time step and then stored in a MySQL database as the first part of the time-specific record. The RMM then performs synchronization of the input times with the current model time, prepares a decision on initialization for the next model time step, and monitors its execution. Then, as soon as the model completes computations for the next time step, RMM visualizes the current model output into various short-term (about 1-2 hours) forecasting products and compares prior results with available ionospheric measurements. The RMM places prepared images into the MySQL database, which can be located on a different computer node, and then proceeds to the next time interval continuing the time-loop. The upper-level interface of this real-time system is the a PHP-based Web site (http://www.arsc.edu/SpaceWeather/new). This site provides general information about the Earth polar and adjacent mid-latitude ionosphere, allows for monitoring of the current developments and short-term forecasts, and facilitates access to the comparisons archive stored in the database.

  20. Enhancing cognate target elution efficiency in gel-free chemical proteomics

    Directory of Open Access Journals (Sweden)

    Branka Radic-Sarikas

    2015-12-01

    Full Text Available Gel-free liquid chromatography mass spectrometry coupled to chemical proteomics is a powerful approach for characterizing cellular target profiles of small molecules. We have previously described a fast and efficient elution protocol; however, altered target profiles were observed. We hypothesised that elution conditions critically impact the effectiveness of disrupting drug-protein interactions. Thus, a number of elution conditions were systematically assessed with the aim of improving the recovery of all classes of proteins whilst maintaining compatibility with immunoblotting procedures. A double elution with formic acid combined with urea emerged as the most efficient and generically applicable elution method for chemical proteomics

  1. 26 CFR 1.6074-2 - Time for filing declarations by corporations in case of a short taxable year.

    Science.gov (United States)

    2010-04-01

    ...(a) are met before the 1st day of the 9th month of the short taxable year, the declaration shall be filed on or before the 15th day of the 9th month of such short year. In the case of a short taxable year...) Example. The application of the provisions of this paragraph may be illustrated by the following example...

  2. A rapid and accurate approach for prediction of interactomes from co-elution data (PrInCE).

    Science.gov (United States)

    Stacey, R Greg; Skinnider, Michael A; Scott, Nichollas E; Foster, Leonard J

    2017-10-23

    An organism's protein interactome, or complete network of protein-protein interactions, defines the protein complexes that drive cellular processes. Techniques for studying protein complexes have traditionally applied targeted strategies such as yeast two-hybrid or affinity purification-mass spectrometry to assess protein interactions. However, given the vast number of protein complexes, more scalable methods are necessary to accelerate interaction discovery and to construct whole interactomes. We recently developed a complementary technique based on the use of protein correlation profiling (PCP) and stable isotope labeling in amino acids in cell culture (SILAC) to assess chromatographic co-elution as evidence of interacting proteins. Importantly, PCP-SILAC is also capable of measuring protein interactions simultaneously under multiple biological conditions, allowing the detection of treatment-specific changes to an interactome. Given the uniqueness and high dimensionality of co-elution data, new tools are needed to compare protein elution profiles, control false discovery rates, and construct an accurate interactome. Here we describe a freely available bioinformatics pipeline, PrInCE, for the analysis of co-elution data. PrInCE is a modular, open-source library that is computationally inexpensive, able to use label and label-free data, and capable of detecting tens of thousands of protein-protein interactions. Using a machine learning approach, PrInCE offers greatly reduced run time, more predicted interactions at the same stringency, prediction of protein complexes, and greater ease of use over previous bioinformatics tools for co-elution data. PrInCE is implemented in Matlab (version R2017a). Source code and standalone executable programs for Windows and Mac OSX are available at https://github.com/fosterlab/PrInCE , where usage instructions can be found. An example dataset and output are also provided for testing purposes. PrInCE is the first fast and easy

  3. Positive Pacing Strategies Are Utilized by Elite Male and Female Para-cyclists in Short Time Trials in the Velodrome.

    Science.gov (United States)

    Wright, Rachel L

    2015-01-01

    In para-cycling, competitors are classed based on functional impairment resulting in cyclists with neurological and locomotor impairments competing against each other. In Paralympic competition, classes are combined by using a factoring adjustment to race times to produce the overall medallists. Pacing in short-duration track cycling events is proposed to utilize an "all-out" strategy in able-bodied competition. However, pacing in para-cycling may vary depending on the level of impairment. Analysis of the pacing strategies employed by different classification groups may offer scope for optimal performance; therefore, this study investigated the pacing strategy adopted during the 1-km time trial (TT) and 500-m TT in elite C1 to C3 para-cyclists and able-bodied cyclists. Total times and intermediate split times (125-m intervals; measured to 0.001 s) were obtained from the C1-C3 men's 1-km TT (n = 28) and women's 500-m TT (n = 9) from the 2012 Paralympic Games and the men's 1-km TT (n = 19) and women's 500-m TT (n = 12) from the 2013 UCI World Track Championships from publically available video. Split times were expressed as actual time, factored time (for the para-cyclists) and as a percentage of total time. A two-way analysis of variance was used to investigate differences in split times between the different classifications and the able-bodied cyclists in the men's 1-km TT and between the para-cyclists and able-bodied cyclists in the women's 500-m TT. The importance of position at the first split was investigated with Kendall's Tau-b correlation. The first 125-m split time was the slowest for all cyclists, representing the acceleration phase from a standing start. C2 cyclists were slowest at this 125-m split, probably due to a combination of remaining seated in this acceleration phase and a high proportion of cyclists in this group being trans-femoral amputees. Not all cyclists used aero-bars, preferring to use drop, flat or bullhorn handlebars. Split times

  4. Positive pacing strategies are utilised by elite male and female para-cyclists in short time trials in the velodrome

    Directory of Open Access Journals (Sweden)

    Rachel Lindsey Wright

    2016-01-01

    Full Text Available In para-cycling, competitors are classed based on functional impairment resulting in cyclists with neurological and locomotor impairments competing against each other. In Paralympic competition, classes are combined by using a factoring adjustment to race times to produce the overall medallists. Pacing in short-duration track cycling events is proposed to utilise an all-out strategy in able-bodied competition. However, pacing in para-cycling may vary depending on the level of impairment. Analysis of the pacing strategies employed by different classification groups may offer scope for optimal performance; therefore, this study investigated the pacing strategy adopted during the 1-km time trial (TT and 500-m TT in elite C1 to C3 para-cyclists and able-bodied cyclists. Total times and intermediate split times (125-m intervals; measured to 0.001s were obtained from the C1-C3 men’s 1-km TT (n=28 and women’s 500-m TT (n=9 from the 2012 Paralympic Games and the men’s 1-km TT (n=19 and women’s 500-m TT (n=12 from the 2013 UCI World Track Championships from publically available video. Split times were expressed as actual time, factored time (for the para-cyclists and as a percentage of total time. A two-way analysis of variance was used to investigate differences in split times between the different classifications and the able-bodied cyclists in the men’s 1-km TT and between the para-cyclists and able-bodied cyclists in the women’s 500-m TT. The importance of position at the first split was investigated with Kendall’s Tau-b correlation. The first 125-m split time was the slowest for all cyclists, representing the acceleration phase from a standing start. C2 cyclists were slowest at this 125-m split, probably due to a combination of remaining seated in this acceleration phase and a high proportion of cyclists in this group being trans-femoral amputees. Not all cyclists used aero-bars, preferring to use drop, flat or bullhorn handlebars

  5. Short time-scale optical variability properties of the largest AGN sample observed with Kepler/K2

    Science.gov (United States)

    Aranzana, E.; Körding, E.; Uttley, P.; Scaringi, S.; Bloemen, S.

    2018-05-01

    We present the first short time-scale (˜hours to days) optical variability study of a large sample of active galactic nuclei (AGNs) observed with the Kepler/K2 mission. The sample contains 252 AGN observed over four campaigns with ˜30 min cadence selected from the Million Quasar Catalogue with R magnitude <19. We performed time series analysis to determine their variability properties by means of the power spectral densities (PSDs) and applied Monte Carlo techniques to find the best model parameters that fit the observed power spectra. A power-law model is sufficient to describe all the PSDs of our sample. A variety of power-law slopes were found indicating that there is not a universal slope for all AGNs. We find that the rest-frame amplitude variability in the frequency range of 6 × 10-6-10-4 Hz varies from 1to10 per cent with an average of 1.7 per cent. We explore correlations between the variability amplitude and key parameters of the AGN, finding a significant correlation of rest-frame short-term variability amplitude with redshift. We attribute this effect to the known `bluer when brighter' variability of quasars combined with the fixed bandpass of Kepler data. This study also enables us to distinguish between Seyferts and blazars and confirm AGN candidates. For our study, we have compared results obtained from light curves extracted using different aperture sizes and with and without detrending. We find that limited detrending of the optimal photometric precision light curve is the best approach, although some systematic effects still remain present.

  6. The short-term effects of air pollutants on respiratory disease mortality in Wuhan, China: comparison of time-series and case-crossover analyses

    OpenAIRE

    Meng Ren; Na Li; Zhan Wang; Yisi Liu; Xi Chen; Yuanyuan Chu; Xiangyu Li; Zhongmin Zhu; Liqiao Tian; Hao Xiang

    2017-01-01

    Few studies have compared different methods when exploring the short-term effects of air pollutants on respiratory disease mortality in Wuhan, China. This study assesses the association between air pollutants and respiratory disease mortality with both time-series and time-stratified?case-crossover designs. The generalized additive model (GAM) and the conditional logistic regression model were used to assess the short-term effects of air pollutants on respiratory disease mortality. Stratified...

  7. Short-Term Interferential Transabdominal Electrical Stimulation Did Not Change Oral-Rectal Transit Time in Piglets.

    Science.gov (United States)

    Tan, Andre Y F; Sourial, Magdy; Hutson, John M; Southwell, Bridget R

    2018-03-02

    Transcutaneous electrical stimulation (TES) using interferential current (IFC) is a new therapeutic treatment for constipation. Clinical studies show that TES-IFC for 3-6 months improves colonic transit, but it is not clear if short-term stimulation affects transit or the effect requires longer to develop. The aim of this study was to determine if TES-IFC for only four days affects oral-rectal transit time in healthy pigs. Twenty-two 4-5-week old large white female piglets had transit studies during week 4 and week 5 by placing a capsule containing 18 radiopaque plastic markers in the esophagus under anesthetic followed by x-rays at 6, 30, 54, and 78 hours. Animals were randomly assigned to active or control groups. The active group received TES for 30 min daily for four days. Interferential current was applied through four electrodes (4 × 4 cm), with two para-spinal just below the last rib and two on the belly at the same level. Stimulation was at 4000 Hz and 4080-4160 Hz with currents crossing through the abdominal cavity. Whole bowel transit times ranged from 7.7 to 72.2 hours, stomach transit from transit time from 5 to 53 hours. Transit times were the same for the control (median 28.4 hours) and TES-IFC (23.0 hours) groups in the prestimulation and stimulation weeks (control 23.0, TES-IFC 19.8 hours) with no change within or between groups. Four days of half-hour TES-IFC daily in healthy 5-week-old piglets did not change oral-rectal transit time. © 2018 International Neuromodulation Society.

  8. Double peak-induced distance error in short-time-Fourier-transform-Brillouin optical time domain reflectometers event detection and the recovery method.

    Science.gov (United States)

    Yu, Yifei; Luo, Linqing; Li, Bo; Guo, Linfeng; Yan, Jize; Soga, Kenichi

    2015-10-01

    The measured distance error caused by double peaks in the BOTDRs (Brillouin optical time domain reflectometers) system is a kind of Brillouin scattering spectrum (BSS) deformation, discussed and simulated for the first time in the paper, to the best of the authors' knowledge. Double peak, as a kind of Brillouin spectrum deformation, is important in the enhancement of spatial resolution, measurement accuracy, and crack detection. Due to the variances of the peak powers of the BSS along the fiber, the measured starting point of a step-shape frequency transition region is shifted and results in distance errors. Zero-padded short-time-Fourier-transform (STFT) can restore the transition-induced double peaks in the asymmetric and deformed BSS, thus offering more accurate and quicker measurements than the conventional Lorentz-fitting method. The recovering method based on the double-peak detection and corresponding BSS deformation can be applied to calculate the real starting point, which can improve the distance accuracy of the STFT-based BOTDR system.

  9. Elution of Clindamycin and Enrofloxacin From Calcium Sulfate Hemihydrate Beads In Vitro.

    Science.gov (United States)

    Phillips, Heidi; Boothe, Dawn M; Bennett, R Avery

    2015-11-01

    To compare the in vitro elution characteristics of clindamycin and enrofloxacin from calcium sulfate hemihydrate beads containing a single antibiotic, both antibiotics, and each antibiotic incubated in the same eluent well. Experimental in vitro study. Calcium sulfate hemihydrate beads were formed by mixing with clindamycin and/or enrofloxacin to create 4 study groups: (1) 160 mg clindamycin/10 beads; (2) 160 mg enrofloxacin/10 beads; (3) 160 mg clindamycin + 160 mg enrofloxacin/10 beads; and (4) 160 mg clindamycin/5 beads and 160 mg enrofloxacin/5 beads. Chains of beads were formed in triplicate and placed in 5 mL phosphate buffered saline (PBS; pH 7.4 and room temperature) with constant agitation. Antibiotic-conditioned PBS was sampled at 14 time points from 1 hour to 30 days. Clindamycin and enrofloxacin concentrations in PBS were determined using high-performance liquid chromatography. Eluent concentrations from clindamycin-impregnated beads failed to remain sufficiently above minimum inhibitory concentration (MIC) for common infecting bacteria over the study period. Enrofloxacin eluent concentrations remained sufficiently above MIC for common wound pathogens of dogs and cats and demonstrated an atypical biphasic release pattern. No significant differences in elution occurred as a result of copolymerization of the antibiotics into a single bead or from individual beads co-eluting in the same eluent well. Clindamycin-impregnated beads cannot be recommended for treatment of infection at the studied doses; however, use of enrofloxacin-impregnated beads may be justified when susceptible bacteria are cultured. © Copyright 2015 by The American College of Veterinary Surgeons.

  10. pH-zone-refining elution-extrusion countercurrent chromatography: Separation of hydroxyanthraquinones from Cassiae semen.

    Science.gov (United States)

    Bu, Zhisi; Lv, Liqiong; Li, Xingnuo; Chu, Chu; Tong, Shengqiang

    2017-11-01

    Seven hydroxyanthraquinones were successfully separated from the traditional Chinese medicinal herb Cassiae semen by conventional and pH-zone-refining countercurrent chromatography with an environmentally friendly biphasic solvent system, in which elution-extrusion mode was investigated for pH-zone-refining countercurrent chromatography for the first time. A two-phase solvent system composed of n-hexane/ethyl acetate/ethanol/water (5:3:4:4, v/v/v/v) was used for the conventional countercurrent chromatography while the same system with a different volume ratio n-hexane/ethyl acetate/ethanol/water (3:5:2:6, v/v/v/v) was used for pH-zone-refining countercurrent chromatography, in which 20 mmol/L of trifluoroacetic acid was added in the organic phase as a retainer and 15 mmol/L of ammonia was added to the aqueous phase as an eluter. A 400 mg crude sample could be well separated by pH-zone-refining countercurrent chromatography, yielding 53 mg of aurantio-obtusin, 40 mg of chryso-obtusin, 18 mg of obtusin, 24 mg of obtusifolin, 10 mg of emodin, and 105 mg of the mixture of chrysophanol and physcion with a purity of over 95.8, 95.7, 96.9, 93.5, 97.4, 77.1, and 19.8%, as determined by high-performance liquid chromatography. Furthermore, the difference in elution sequence between conventional and pH-zone-refining mode was observed and discussed. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Evaluation of short repetition time, partial flip angle, gradient recalled echo pulse sequences in cervical spine imaging

    International Nuclear Information System (INIS)

    Enzmann, D.; Rubin, J.B.

    1987-01-01

    A short repetition time (TR), partial flip angle, gradient recalled echo pulse sequence (GRASS) was prospectively studied to optimize it for the diagnosis of cervical disk and cord disease in 98 patients. Changes in signal-to-noise ratio (SNR) and contrast were measured as the following parameters were varied: flip angle (3 0 to 18 0 ), TR (22-60 msec), and echo time (TE) (12.5-25 msec). Flip angle was the single most important parameter. For disk disease, cerebrospinal fluid (CSF) SNR peaked at an 8 0 flip angle in the axial view but at a 4 0 flip angle in the sagittal view. In the sagittal view, disk-CSF contrast decreased progressively from a flip angle of 3 0 , while in the axial view it peaked at 10 0 . For cord lesions the findings were similar except that lesion-cord contrast could be increased by lengthening both TR and TE. No one combination of parameters proved greatly superior for either disk disease or cord disease. The selection of parameters required balancing of several factors that often had opposing effects

  12. A probabilistic method for the estimation of ocean surface currents from short time series of HF radar data

    Science.gov (United States)

    Guérin, Charles-Antoine; Grilli, Stéphan T.

    2018-01-01

    We present a new method for inverting ocean surface currents from beam-forming HF radar data. In contrast with the classical method, which inverts radial currents based on shifts of the main Bragg line in the radar Doppler spectrum, the method works in the temporal domain and inverts currents from the amplitude modulation of the I and Q radar time series. Based on this principle, we propose a Maximum Likelihood approach, which can be combined with a Bayesian inference method assuming a prior current distribution, to infer values of the radial surface currents. We assess the method performance by using synthetic radar signal as well as field data, and systematically comparing results with those of the Doppler method. The new method is found advantageous for its robustness to noise at long range, its ability to accommodate shorter time series, and the possibility to use a priori information to improve the estimates. Limitations are related to current sign errors at far-ranges and biased estimates for small current values and very short samples. We apply the new technique to a data set from a typical 13.5 MHz WERA radar, acquired off of Vancouver Island, BC, and show that it can potentially improve standard synoptic current mapping.

  13. A Bayesian method for characterizing distributed micro-releases: II. inference under model uncertainty with short time-series data.

    Energy Technology Data Exchange (ETDEWEB)

    Marzouk, Youssef; Fast P. (Lawrence Livermore National Laboratory, Livermore, CA); Kraus, M. (Peterson AFB, CO); Ray, J. P.

    2006-01-01

    Terrorist attacks using an aerosolized pathogen preparation have gained credibility as a national security concern after the anthrax attacks of 2001. The ability to characterize such attacks, i.e., to estimate the number of people infected, the time of infection, and the average dose received, is important when planning a medical response. We address this question of characterization by formulating a Bayesian inverse problem predicated on a short time-series of diagnosed patients exhibiting symptoms. To be of relevance to response planning, we limit ourselves to 3-5 days of data. In tests performed with anthrax as the pathogen, we find that these data are usually sufficient, especially if the model of the outbreak used in the inverse problem is an accurate one. In some cases the scarcity of data may initially support outbreak characterizations at odds with the true one, but with sufficient data the correct inferences are recovered; in other words, the inverse problem posed and its solution methodology are consistent. We also explore the effect of model error-situations for which the model used in the inverse problem is only a partially accurate representation of the outbreak; here, the model predictions and the observations differ by more than a random noise. We find that while there is a consistent discrepancy between the inferred and the true characterizations, they are also close enough to be of relevance when planning a response.

  14. Nucleoside uptake in macrophages from various murine strains: a short-time and a two-step stimulation model

    International Nuclear Information System (INIS)

    Busolo, F.; Conventi, L.; Grigolon, M.; Palu, G.

    1991-01-01

    Kinetics of [3H]-uridine uptake by murine peritoneal macrophages (pM phi) is early altered after exposure to a variety of stimuli. Alterations caused by Candida albicans, lipopolysaccharide (LPS) and recombinant interferon-gamma (rIFN-gamma) were similar in SAVO, C57BL/6, C3H/HeN and C3H/HeJ mice, and were not correlated with an activation process as shown by the amount of tumor necrosis factor-alpha (TNF-alpha) being released. Short-time exposure to all stimuli resulted in an increased nucleoside uptake by SAVO pM phi, suggesting that the tumoricidal function of this cell either depends from the type of stimulus or the time when the specific interaction with the cell receptor is taking place. Experiments with priming and triggering signals confirmed the above findings, indicating that the increase or the decrease of nucleoside uptake into the cell depends essentially on the chemical nature of the priming stimulus. The triggering stimulus, on the other hand, is only able to amplify the primary response

  15. Analysis of lightning fault detection, location and protection on short and long transmission lines using Real Time Digital Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Andre Luiz Pereira de [Siemens Ltda., Sao Paulo, SP (Brazil)], E-mail: andreluiz.oliveira@siemens.com

    2007-07-01

    The purpose of this paper is to present an analysis of lightning fault detection, location and protection using numeric distance relays applied in high voltage transmission lines, more specifically in the 500 kV transmission lines of CEMIG (Brazilian Energy Utility) between the Vespasiano 2 - Neves 1 (short line - 23.9 km) and Vespasiano 2 - Mesquita (long line - 148.6 km) substations. The analysis was based on the simulations results of numeric distance protective relays on power transmission lines, realized in September 02 to 06, 2002, at Siemens AG's facilities (Erlangen - Germany), using Real Time Digital Simulator (RTDS{sup TM}). Several lightning faults simulations were accomplished, in several conditions of the electrical power system where the protective relays would be installed. The results are presented not only with the times of lightning faults elimination, but also all the functionality of a protection system, including the correct detection, location and other advantages that these modern protection devices make possible to the power system. (author)

  16. Unfolding and aggregation of a glycosylated monoclonal antibody on a cation exchange column. Part I. Chromatographic elution and batch adsorption behavior.

    Science.gov (United States)

    Guo, Jing; Zhang, Shaojie; Carta, Giorgio

    2014-08-22

    A glycosylated IgG2 monoclonal antibody exhibits a two-peak elution behavior when loaded on a strong cation exchange column and eluted with either a linear salt gradient or two salt steps at increasing salt concentrations. The two-peak behavior is more pronounced for conditions where the initial antibody binding is stronger, i.e. at lower pH and buffer concentration, where the hold time prior to elution is longer, where the protein mass load is lower, and where the load flow rate is higher. The effect is also dependent on the resin type, being prominent for the polymer-functionalized resin Fractogel EMD SO₃(-) and virtually absent for a macroporous resin with similar backbone but no grafted polymers. Size exclusion chromatography and dynamic light scattering show that the early eluting peak consists exclusively of the native monomeric species while the late eluting peak is a mixture of monomeric and aggregated species. Batch adsorption/desorption experiments show that the bound protein can be desorbed in two steps, with a fraction desorbed in 0.33 M NaCl, corresponding to native monomer, and a second fraction desorbed in 1M NaCl. The latter fraction decreases with protein mass load and becomes almost negligible when the resin is initially completely saturated with protein. Confocal laser scanning microscopy showed that the two-peak elution/desorption behavior is related to the unique kinetics of protein binding in the Fractogel resin. Following partial loading of the resin, the bound protein migrates toward the center of the particles during a hold step and is redistributed across the particle volume attaining low local bound protein concentrations. For these conditions the protein is apparently destabilized forming a strongly-bound unfolded intermediate that, in turn, generates aggregates upon elution in high salt. Copyright © 2014 Elsevier B.V. All rights reserved.

  17. Comparison of an everolimus-eluting bioresorbable scaffold with an everolimus-eluting metallic stent for the treatment of coronary artery stenosis (ABSORB II)

    DEFF Research Database (Denmark)

    Serruys, Patrick W; Chevalier, Bernard; Sotomi, Yohei

    2016-01-01

    BACKGROUND: No medium-term data are available on the random comparison between everolimus-eluting bioresorbable vascular scaffolds and everolimus-eluting metallic stents. The study aims to demonstrate two mechanistic properties of the bioresorbable scaffold: increase in luminal dimensions as a re...

  18. Effect of Post-Dilatation Following Primary PCI With Everolimus-Eluting Bioresorbable Scaffold Versus Everolimus-Eluting Metallic Stent Implantation

    DEFF Research Database (Denmark)

    Yamaji, Kyohei; Brugaletta, Salvatore; Sabaté, Manel

    2017-01-01

    OBJECTIVES: This study sought to investigate the effect of post-dilatation on angiographic and intracoronary imaging parameters in the setting of primary percutaneous coronary intervention comparing the everolimus-eluting bioresorbable scaffold (BRS) with the everolimus-eluting metallic stent (EE...

  19. Modelling the short term interest with stochastic differential equation in continuous time: linear versus non-linear mode

    OpenAIRE

    2014-01-01

    M.Com. (Financial Economics) Recently, there has been a growth in the bond market. This growth has brought with it an ever-increasing volume and range of interest rate depended derivative products known as interest rate derivatives. Amongst the variables used in pricing these derivative products is the short-term interest rate. A numbers of short-term interest rate models that are used to fit the short-term interest rate exist. Therefore, understanding the features characterised by various...

  20. Simulation of elution profiles in liquid chromatography - II: Investigation of injection volume overload under gradient elution conditions applied to second dimension separations in two-dimensional liquid chromatography.

    Science.gov (United States)

    Stoll, Dwight R; Sajulga, Ray W; Voigt, Bryan N; Larson, Eli J; Jeong, Lena N; Rutan, Sarah C

    2017-11-10

    An important research direction in the continued development of two-dimensional liquid chromatography (2D-LC) is to improve the detection sensitivity of the method. This is especially important in applications where injection of large volumes of effluent from the first dimension ( 1 D) column into the second dimension ( 2 D) column leads to severe 2 D peak broadening and peak shape distortion. For example, this is common when coupling two reversed-phase columns and the organic solvent content of the 1 D mobile phase overwhelms the 2 D column with each injection of 1 D effluent, leading to low resolution in the second dimension. In a previous study we validated a simulation approach based on the Craig distribution model and adapted from the work of Czok and Guiochon [1] that enabled accurate simulation of simple isocratic and gradient separations with very small injection volumes, and isocratic separations with mismatched injection and mobile phase solvents [2]. In the present study we have extended this simulation approach to simulate separations relevant to 2D-LC. Specifically, we have focused on simulating 2 D separations where gradient elution conditions are used, there is mismatch between the sample solvent and the starting point in the gradient elution program, injection volumes approach or even exceed the dead volume of the 2 D column, and the extent of sample loop filling is varied. To validate this simulation we have compared results from simulations and experiments for 101 different conditions, including variation in injection volume (0.4-80μL), loop filling level (25-100%), and degree of mismatch between sample organic solvent and the starting point in the gradient elution program (-20 to +20% ACN). We find that that the simulation is accurate enough (median errors in retention time and peak width of -1.0 and -4.9%, without corrections for extra-column dispersion) to be useful in guiding optimization of 2D-LC separations. However, this requires that real

  1. Zotarolimus-eluting durable-polymer-coated stent versus a biolimus-eluting biodegradable-polymer-coated stent in unselected patients undergoing percutaneous coronary intervention (SORT OUT VI)

    DEFF Research Database (Denmark)

    Raungaard, Bent; Jensen, Lisette Okkels; Tilsted, Hans-Henrik

    2015-01-01

    BACKGROUND: New-generation drug-eluting coronary stents have reduced the risk of coronary events, especially in patients with complex disease or lesions. To what extent different stent platforms, polymers, and antiproliferative drugs affect outcomes, however, is unclear. We investigated the safety...... and efficacy of a third-generation stent by comparing a highly biocompatible durable-polymer-coated zotarolimus-eluting stent with a biodegradable-polymer-coated biolimus-eluting stent. METHODS: This open-label, randomised, multicentre, non-inferiority trial was done at three sites across western Denmark. All......-polymer zotarolimus-eluting stent or the biodegradable-polymer biolimus-eluting stent. The primary endpoint was a composite of safety (cardiac death and myocardial infarction not clearly attributable to a non-target lesion) and efficacy (target-lesion revascularisation) at 12 months, analysed by intention to treat...

  2. Finite-size effects in the short-time height distribution of the Kardar-Parisi-Zhang equation

    Science.gov (United States)

    Smith, Naftali R.; Meerson, Baruch; Sasorov, Pavel

    2018-02-01

    We use the optimal fluctuation method to evaluate the short-time probability distribution P(H, L, t) of height at a single point, H=h(x=0, t) , of the evolving Kardar-Parisi-Zhang (KPZ) interface h(x, t) on a ring of length 2L. The process starts from a flat interface. At short times typical (small) height fluctuations are unaffected by the KPZ nonlinearity and belong to the Edwards-Wilkinson universality class. The nonlinearity, however, strongly affects the (asymmetric) tails of P(H) . At large L/\\sqrt{t} the faster-decaying tail has a double structure: it is L-independent, -\\lnP˜≤ft\\vert H\\right\\vert 5/2/t1/2 , at intermediately large \\vert H\\vert , and L-dependent, -\\lnP˜ ≤ft\\vert H\\right\\vert 2L/t , at very large \\vert H\\vert . The transition between these two regimes is sharp and, in the large L/\\sqrt{t} limit, behaves as a fractional-order phase transition. The transition point H=Hc+ depends on L/\\sqrt{t} . At small L/\\sqrt{t} , the double structure of the faster tail disappears, and only the very large-H tail, -\\lnP˜ ≤ft\\vert H\\right\\vert 2L/t , is observed. The slower-decaying tail does not show any L-dependence at large L/\\sqrt{t} , where it coincides with the slower tail of the GOE Tracy-Widom distribution. At small L/\\sqrt{t} this tail also has a double structure. The transition between the two regimes occurs at a value of height H=Hc- which depends on L/\\sqrt{t} . At L/\\sqrt{t} \\to 0 the transition behaves as a mean-field-like second-order phase transition. At \\vert H\\vert c-\\vert the slower tail behaves as -\\lnP˜ ≤ft\\vert H\\right\\vert 2L/t , whereas at \\vert H\\vert >\\vert H_c-\\vert it coincides with the slower tail of the GOE Tracy-Widom distribution.

  3. Thermal inactivation of foot-and-mouth disease virus in milk using high-temperature, short-time pasteurization.

    Science.gov (United States)

    Tomasula, P M; Kozempel, M F; Konstance, R P; Gregg, D; Boettcher, S; Baxt, B; Rodriguez, L L

    2007-07-01

    Previous studies of laboratory simulation of high temperature, short time pasteurization (HTST) to eliminate foot-and-mouth disease virus (FMDV) in milk have shown that the virus is not completely inactivated at the legal pasteurization minimum (71.7 degrees C/15 s) but is inactivated in a flow apparatus at 148 degrees C with holding times of 2 to 3 s. It was the intent of this study to determine whether HTST pasteurization conducted in a continuous-flow pasteurizer that simulates commercial operation would enhance FMDV inactivation in milk. Cows were inoculated in the mammary gland with the field strain of FMDV (01/UK). Infected raw whole milk and 2% milk were then pasteurized using an Arm-field pilot-scale, continuous-flow HTST pasteurizer equipped with a plate-and-frame heat exchanger and a holding tube. The milk samples, containing FMDV at levels of up to 10(4) plaque-forming units/mL, were pasteurized at temperatures ranging from 72 to 95 degrees C at holding times of either 18.6 or 36 s. Pasteurization decreased virus infectivity by 4 log10 to undetectable levels in tissue culture. However, residual infectivity was still detectable for selected pasteurized milk samples, as shown by intramuscular and intradermal inoculation of milk into naïve steers. Although HTST pasteurization did not completely inactivate viral infectivity in whole and 2% milk, possibly because a fraction of the virus was protected by the milk fat and the casein proteins, it greatly reduced the risk of natural transmission of FMDV by milk.

  4. Interactions of Grazing History, Cattle Removal and Time since Rain Drive Divergent Short-Term Responses by Desert Biota

    Science.gov (United States)

    Frank, Anke S. K.; Dickman, Chris R.; Wardle, Glenda M.; Greenville, Aaron C.

    2013-01-01

    Arid grasslands are used worldwide for grazing by domestic livestock, generating debate about how this pastoral enterprise may influence native desert biota. One approach to resolving this question is to experimentally reduce livestock numbers and measure the effects. However, a key challenge in doing this is that historical grazing impacts are likely to be cumulative and may therefore confound comparisons of the short-term responses of desert biota to changes in stocking levels. Arid areas are also subject to infrequent flooding rainfalls that drive productivity and dramatically alter abundances of flora and fauna. We took advantage of an opportunity to study the recent effects of a property-scale cattle removal on two properties with similarly varied grazing histories in central Australia. Following the removal of cattle in 2006 and before and after a significant rainfall event at the beginning of 2007, we sampled vegetation and small vertebrates on eight occasions until October 2008. Our results revealed significant interactions of time of survey with both grazing history and grazing removal for vascular plants, small mammals and reptiles. The mammals exhibited a three-way interaction of time, grazing history and grazing removal, thus highlighting the importance of careful sampling designs and timing for future monitoring. The strongest response to the cessation of grazing after two years was depressed reproductive output of plants in areas where cattle continued to graze. Our results confirm that neither vegetation nor small vertebrates necessarily respond immediately to the removal of livestock, but that rainfall events and cumulative grazing history are key determinants of floral and faunal performance in grassland landscapes with low and variable rainfall. We suggest that improved assessments could be made of the health of arid grazing environments if long-term monitoring were implemented to track the complex interactions that influence how native biota

  5. Biodegradable-Polymer Biolimus-Eluting Stents versus Durable-Polymer Everolimus-Eluting Stents at One-Year Follow-Up: A Registry-Based Cohort Study.

    Science.gov (United States)

    Parsa, Ehsan; Saroukhani, Sepideh; Majlessi, Fereshteh; Poorhosseini, Hamidreza; Lofti-Tokaldany, Masoumeh; Jalali, Arash; Salarifar, Mojtaba; Nematipour, Ebrahim; Alidoosti, Mohammad; Aghajani, Hassan; Amirzadegan, Alireza; Kassaian, Seyed Ebrahim

    2016-04-01

    We compared outcomes of percutaneous coronary intervention patients who received biodegradable-polymer biolimus-eluting stents with those who received durable-polymer everolimus-eluting stents. At Tehran Heart Center, we performed a retrospective analysis of the data from January 2007 through December 2011 on 3,270 consecutive patients with coronary artery disease who underwent percutaneous coronary intervention with the biodegradable-polymer biolimus-eluting stent or the durable-polymer everolimus-eluting stent. We excluded patients with histories of coronary artery bypass grafting or percutaneous coronary intervention, acute ST-segment-elevation myocardial infarction, or the implantation of 2 different stent types. Patients were monitored for 12 months. The primary endpoint was a major adverse cardiac event, defined as a composite of death, nonfatal myocardial infarction, and target-vessel and target-lesion revascularization. Durable-polymer everolimus-eluting stents were implanted in 2,648 (81%) and biodegradable-polymer biolimus-eluting stents in 622 (19%) of the study population. There was no significant difference between the 2 groups (2.7% vs 2.7%; P=0.984) in the incidence of major adverse cardiac events. The cumulative adjusted probability of major adverse cardiac events in the biodegradable-polymer biolimus-eluting stent group did not differ from that of such events in the durable-polymer everolimus-eluting stent group (hazard ratio=0.768; 95% confidence interval, 0.421-1.44; P=0.388). We conclude that in our patients the biodegradable-polymer biolimus-eluting stent was as effective and safe, during the 12-month follow-up period, as was the durable-polymer everolimus-eluting stent.

  6. Optimization of Drug Delivery by Drug-Eluting Stents.

    Directory of Open Access Journals (Sweden)

    Franz Bozsak

    Full Text Available Drug-eluting stents (DES, which release anti-proliferative drugs into the arterial wall in a controlled manner, have drastically reduced the rate of in-stent restenosis and revolutionized the treatment of atherosclerosis. However, late stent thrombosis remains a safety concern in DES, mainly due to delayed healing of the endothelial wound inflicted during DES implantation. We present a framework to optimize DES design such that restenosis is inhibited without affecting the endothelial healing process. To this end, we have developed a computational model of fluid flow and drug transport in stented arteries and have used this model to establish a metric for quantifying DES performance. The model takes into account the multi-layered structure of the arterial wall and incorporates a reversible binding model to describe drug interaction with the cells of the arterial wall. The model is coupled to a novel optimization algorithm that allows identification of optimal DES designs. We show that optimizing the period of drug release from DES and the initial drug concentration within the coating has a drastic effect on DES performance. Paclitaxel-eluting stents perform optimally by releasing their drug either very rapidly (within a few hours or very slowly (over periods of several months up to one year at concentrations considerably lower than current DES. In contrast, sirolimus-eluting stents perform optimally only when drug release is slow. The results offer explanations for recent trends in the development of DES and demonstrate the potential for large improvements in DES design relative to the current state of commercial devices.

  7. Speech Timing and Verbal Short-Term Memory: Evidence for Contrasting Deficits in Down Syndrome and Williams Syndrome

    Science.gov (United States)

    Jarrold, Christopher; Cowan, Nelson; Hewes, Alexa K.; Riby, Deborah M.

    2004-01-01

    This study explored the degree of verbal short-term memory deficit among individuals with Down syndrome and Williams syndrome, and the extent to which any such impairment could be accounted for by a relative slowing of rehearsal and output processes. Measures of serial recall and detailed assessments of speeded articulation for short and long…

  8. Enhancement mechanisms of short-time aerobic digestion for waste activated sludge in the presence of cocoamidopropyl betaine.

    Science.gov (United States)

    Xia, Siqing; Zhou, Yun; Eustance, Everett; Zhang, Zhiqiang

    2017-10-18

    Cocoamidopropyl betaine (CAPB), which is a biodegradable ampholytic surfactant, has recently been found to dramatically enhance the aerobic digestion of waste activated sludge (WAS) in short-time aerobic digestion (STAD) systems. Therefore, it is important to understand the mechanisms in which CAPB enhances WAS aerobic digestion performance. Results showed that CAPB could dramatically enhance the solubilization of soluble proteins (PN), polysaccharides (PS), nucleic acids (NA) and humic-like substances (HS) in the STAD system within the initial 2 h. Then PN, PS and NA gradually decreased, while HS showed only minor decease. In addition, CAPB increased the proportion of low MW fractions (biodegradable. Specific oxygen uptake rates and dehydrogenase enzyme activity results indicated that CAPB markedly improved the aerobic microorganism activities. Microbial community analyses and principle coordinate analyses (PCoA) revealed that CAPB increased the proportion of some functional microorganisms, including Proteobacteria, Planctomycetales, Acinetobacter, Pseudomonas and Aeromonas. The changes driven by CAPB could explain the enhanced performance of the STAD system for WAS aerobic treatment.

  9. Comparison of high pressure and high temperature short time processing on quality of carambola juice during cold storage.

    Science.gov (United States)

    Huang, Hsiao-Wen; Chen, Bang-Yuan; Wang, Chung-Yi

    2018-05-01

    This study validated high hydrostatic pressure processing (HPP) for achieving greater than 5-log reductions of Escherichia coli O157:H7 in carambola juice and determined shelf life of processed juice stored at 4 °C. Carambola juice processed at 600 MPa for 150 s was identified capable of achieving greater than 5.15-log reductions of E. coli O157:H7, and the quality was compared with that of high temperature short time (HTST)-pasteurized juice at 110 °C for 8.6 s. Aerobic, psychrotrophic, E. coli /coliform, and yeasts and moulds in the juice were reduced by HPP or HTST to levels below the minimum detection limit (HTST juices. However, HTST treatment significantly changed the color of juice, while no significant difference was observed between the control and HPP samples. HPP and HTST treatments reduced the total soluble solids in the juice, but maintained higher sucrose, glucose, fructose, and total sugar contents than untreated juice. The total phenolic and ascorbic acid contents were higher in juice treated with HPP than untreated and HTST juice, but there was no significant difference in the flavonoid content. Aroma score analysis showed that HPP had no effect on aroma, maintaining the highest score during cold storage. The results of this study suggest that appropriate HPP conditions can achieve the same microbial safety as HTST, while maintaining the quality and extending the shelf life of carambola juice.

  10. Crispy banana obtained by the combination of a high temperature and short time drying stage and a drying process

    Directory of Open Access Journals (Sweden)

    K. Hofsetz

    2005-06-01

    Full Text Available The effect of the high temperature and short time (HTST drying stage was combined with an air drying process to produce crispness in bananas. The fruit was dehydrated in an air drier for five minutes at 70°C and then immediately set at a HTST stage (130, 140, 150°C and 9, 12, 15 minutes and then at 70°C until water activity (a w was around 0.300. Crispness was evaluated as a function of water activity, using sensory and texture analyses. Drying kinetics was evaluated using the empirical Lewis model. Crispy banana was obtained at 140°C-12min and 150°C-15min in the HTST stage, with a w = 0.345 and a w = 0.363, respectively. Analysis of the k parameter (Lewis model suggests that the initial moisture content of the samples effects this parameter, overcoming the HTST effect. Results showed a relationship between sensory crispness, instrumental texture and the HTST stage.

  11. Treatment of Fungal Bioaerosols by a High-Temperature, Short-Time Process in a Continuous-Flow System▿

    Science.gov (United States)

    Jung, Jae Hee; Lee, Jung Eun; Lee, Chang Ho; Kim, Sang Soo; Lee, Byung Uk

    2009-01-01

    Airborne fungi, termed fungal bioaerosols, have received attention due to the association with public health problems and the effects on living organisms in nature. There are growing concerns that fungal bioaerosols are relevant to the occurrence of allergies, opportunistic diseases in hospitals, and outbreaks of plant diseases. The search for ways of preventing and curing the harmful effects of fungal bioaerosols has created a high demand for the study and development of an efficient method of controlling bioaerosols. However, almost all modern microbiological studies and theories have focused on microorganisms in liquid and solid phases. We investigated the thermal heating effects on fungal bioaerosols in a continuous-flow environment. Although the thermal heating process has long been a traditional method of controlling microorganisms, the effect of a continuous high-temperature, short-time (HTST) process on airborne microorganisms has not been quantitatively investigated in terms of various aerosol properties. Our experimental results show that the geometric mean diameter of the tested fungal bioaerosols decreased when they were exposed to increases in the surrounding temperature. The HTST process produced a significant decline in the (1→3)-β-d-glucan concentration of fungal bioaerosols. More than 99% of the Aspergillus versicolor and Cladosporium cladosporioides bioaerosols lost their culturability in about 0.2 s when the surrounding temperature exceeded 350°C and 400°C, respectively. The instantaneous exposure to high temperature significantly changed the surface morphology of the fungal bioaerosols. PMID:19201954

  12. High-temperature short-time pasteurisation of human breastmilk is efficient in retaining protein and reducing the bacterial count.

    Science.gov (United States)

    Klotz, Daniel; Joellenbeck, Mirjam; Winkler, Karl; Kunze, Mirjam; Huzly, Daniela; Hentschel, Roland

    2017-05-01

    Milk banks are advised to use Holder pasteurisation to inactivate the cytomegalovirus, but the process adversely affects the bioactive properties of human breastmilk. This study explored the antibacterial efficacy of an alternative high-temperature short-time (HTST) treatment of human breastmilk and its effect on marker proteins, compared with the Holder method. Breastmilk samples were obtained from 27 mothers with infants in a German neonatal intensive care unit. The samples were either heated to 62°C for five seconds using HTST or processed using Holder pasteurisation, at 63 ± 0.5°C for 30 minutes. Immunoglobulin A, lactoferrin, lysozyme, alkaline phosphatase and bile salt-stimulated lipase concentrations and bacterial colony-forming units/mL were measured before and after heating. HTST-treated samples retained higher rates of immunoglobulin A (95% versus 83%), alkaline phosphatase (6% versus 0%) and bile salt-stimulated lipase (0.8% versus 0.4%) than Holder pasteurisation samples (all p HTST treatment protocol retained some of the bioactive properties of human breastmilk and appeared to have similar antibacterial efficacy to Holder pasteurisation. ©2017 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

  13. Treatment of fungal bioaerosols by a high-temperature, short-time process in a continuous-flow system.

    Science.gov (United States)

    Jung, Jae Hee; Lee, Jung Eun; Lee, Chang Ho; Kim, Sang Soo; Lee, Byung Uk

    2009-05-01

    Airborne fungi, termed fungal bioaerosols, have received attention due to the association with public health problems and the effects on living organisms in nature. There are growing concerns that fungal bioaerosols are relevant to the occurrence of allergies, opportunistic diseases in hospitals, and outbreaks of plant diseases. The search for ways of preventing and curing the harmful effects of fungal bioaerosols has created a high demand for the study and development of an efficient method of controlling bioaerosols. However, almost all modern microbiological studies and theories have focused on microorganisms in liquid and solid phases. We investigated the thermal heating effects on fungal bioaerosols in a continuous-flow environment. Although the thermal heating process has long been a traditional method of controlling microorganisms, the effect of a continuous high-temperature, short-time (HTST) process on airborne microorganisms has not been quantitatively investigated in terms of various aerosol properties. Our experimental results show that the geometric mean diameter of the tested fungal bioaerosols decreased when they were exposed to increases in the surrounding temperature. The HTST process produced a significant decline in the (1-->3)-beta-d-glucan concentration of fungal bioaerosols. More than 99% of the Aspergillus versicolor and Cladosporium cladosporioides bioaerosols lost their culturability in about 0.2 s when the surrounding temperature exceeded 350 degrees C and 400 degrees C, respectively. The instantaneous exposure to high temperature significantly changed the surface morphology of the fungal bioaerosols.

  14. Evaluation of short-term physical weathering of a heavy fuel oil by use of time warping and PCA

    International Nuclear Information System (INIS)

    Malmquist, L.M.V.; Olsen, R.R.; Christensen, J.H.; Andersen, O.

    2005-01-01

    An estimated 1,140 billion tons of oil was accidentally spilled to the environment during the 1990s. These spills present an ecotoxicologic risk due to the presence of toxic and mutagenic compounds in the oil. Oil is affected by short term and long term weathering processes such as evaporation, dissolution, dispersion, emulsification, photodegradation and biodegradation. Physical weathering processes change the composition of the oil but they do not alter the oil components. Gas chromatography and mass spectrometry can characterize the compositional changes resulting from evaporation. However, the process depends on subjective analysis because it is based on manual interpretation of results and visual inspection. This paper presents a rapid and objective method to compare oil sample compositions. The method is based on automated data preprocessing involving baseline removal, alignment of chromatograms using correlation optimized warping (COW) and normalization. Preprocessed data is analyzed by principal component analysis (PCA) based on the total chromatograms. The method has successfully resolved the effects of evaporation and dissolution processes and showed clear dependence of time, but it did not completely resolve the effect of weathering from the analytical variability because better quality data is required. 21 refs., 3 figs

  15. Relationship of Corneal Pain Sensitivity With Dry Eye Symptoms in Dry Eye With Short Tear Break-Up Time.

    Science.gov (United States)

    Kaido, Minako; Kawashima, Motoko; Ishida, Reiko; Tsubota, Kazuo

    2016-03-01

    The purpose of this prospective comparative study was to investigate corneal sensitivity in subjects with unstable tear film, with and without dry eye (DE) symptoms. Forty-one eyes of 41 volunteers (mean age: 45.1 ± 9.4 years; age range, 23-57 years), with normal tear function and ocular surface except for tear stability, were studied. The eyes were divided into two groups depending on the presence or absence of DE symptoms: 21 eyes with DE symptoms (symptomatic group); and 20 eyes without DE symptoms (asymptomatic group). Three types of corneal sensitivity values were measured using a Cochet-Bonnet esthesiometer: the sensitivity for perception of touch (S-touch), the sensitivity for blinking (S-blink), and the sensitivity for pain (S-pain). Mean S-blink and S-pain were significantly higher in the symptomatic group than in the asymptomatic group (P 0.05). Corneal sensitivity for blinking and pain evoked by increased stimuli was higher in the symptomatic group (subjects with short break-up time DE) compared with subjects who have no DE symptoms despite decreased tear stability. The presence of both tear instability and hyperesthesia, rather than tear instability alone, may contribute to DE pathogenesis.

  16. Evidence of increased endometrial vascular permeability at the time of implantation in the short-nosed fruit bat, Cyanopterus sphinx.

    Science.gov (United States)

    Pakrasi, Pranab Lal; Tiwari, Anjana

    2007-09-01

    Early embryonic development and implantation were studied in tropical short-nosed fruit bat Cyanopterus sphinx. We report preimplantation development and embryo implantation. Different stages of cleavage were observed in embryo by direct microscopic examination of fresh embryos after retrieving them either from the oviduct or the uterus at different days, up to the day of implantation. Generally, the embryos enter the uterus at the 8-cell stage. Embryonic development continued without any delay and blastocyst were formed showing attachment to the uterine epithelium at the mesometrial side of the uterus. A distinct blue band was formed in the uterus. The site of blastocyst attachment was visualized as a blue band following intravenous injection of pontamine blue. Implantation occurred 9+/-0.7 days after mating. This study reports that bat embryonic development can be studied like other laboratory animals and that this bat shows blue dye reaction, indicating the site and exact time of implantation. This blue dye reaction can be used to accurately find post-implantational delay. We prove conclusively that this species of tropical bat does not have any type of embryonic diapause.

  17. Evaluation of short-term physical weathering of a heavy fuel oil by use of time warping and PCA

    Energy Technology Data Exchange (ETDEWEB)

    Malmquist, L.M.V.; Olsen, R.R. [Roskilde Univ., Roskilde (Denmark). Dept. of Life Sciences and Chemistry]|[National Environmental Research Inst., Roskilde (Denmark). Dept. of Environmental Chemistry and Microbiology; Christensen, J.H. [Royal Veterinary and Agricultural Univ., Thorvaldsensvej (Denmark). Dept. of Natural Sciences; Andersen, O. [Roskilde Univ., Roskilde (Denmark). Dept. of Life Sciences and Chemistry

    2005-07-01

    An estimated 1,140 billion tons of oil was accidentally spilled to the environment during the 1990s. These spills present an ecotoxicologic risk due to the presence of toxic and mutagenic compounds in the oil. Oil is affected by short term and long term weathering processes such as evaporation, dissolution, dispersion, emulsification, photodegradation and biodegradation. Physical weathering processes change the composition of the oil but they do not alter the oil components. Gas chromatography and mass spectrometry can characterize the compositional changes resulting from evaporation. However, the process depends on subjective analysis because it is based on manual interpretation of results and visual inspection. This paper presents a rapid and objective method to compare oil sample compositions. The method is based on automated data preprocessing involving baseline removal, alignment of chromatograms using correlation optimized warping (COW) and normalization. Preprocessed data is analyzed by principal component analysis (PCA) based on the total chromatograms. The method has successfully resolved the effects of evaporation and dissolution processes and showed clear dependence of time, but it did not completely resolve the effect of weathering from the analytical variability because better quality data is required. 21 refs., 3 figs.

  18. Demonstration of a time-integrated short line of sight neutron imaging system for inertial confinement fusion

    Energy Technology Data Exchange (ETDEWEB)

    Simpson, R., E-mail: raspberry@lanl.gov; Danly, C.; Fatherley, V. E.; Merrill, F. E.; Volegov, P.; Wilde, C. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Christensen, K.; Fittinghoff, D.; Grim, G. P.; Izumi, N.; Jedlovec, D.; Skulina, K. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States)

    2015-12-15

    The Neutron Imaging System (NIS) is an important diagnostic for understanding implosions of deuterium-tritium capsules at the National Ignition Facility. While the detectors for the existing system must be positioned 28 m from the source to produce sufficient imaging magnification and resolution, recent testing of a new short line of sight neutron imaging system has shown sufficient resolution to allow reconstruction of the source image with quality similar to that of the existing NIS on a 11.6 m line of sight. The new system used the existing pinhole aperture array and a stack of detectors composed of 2 mm thick high-density polyethylene converter material followed by an image plate. In these detectors, neutrons enter the converter material and interact with protons, which recoil and deposit energy within the thin active layer of the image plate through ionization losses. The described system produces time-integrated images for all neutron energies passing through the pinhole. We present details of the measurement scheme for this novel technique to produce energy-integrated neutron images as well as source reconstruction results from recent experiments at NIF.

  19. Untargeted LC-MS/MS Profiling of Cell Culture Media Formulations for Evaluation of High Temperature Short Time Treatment Effects.

    Science.gov (United States)

    Floris, Patrick; McGillicuddy, Nicola; Albrecht, Simone; Morrissey, Brian; Kaisermayer, Christian; Lindeberg, Anna; Bones, Jonathan

    2017-09-19

    An untargeted LC-MS/MS platform was implemented for monitoring variations in CHO cell culture media upon exposure to high temperature short time (HTST) treatment, a commonly used viral clearance upstream strategy. Chemically defined (CD) and hydrolysate-supplemented media formulations were not visibly altered by the treatment. The absence of solute precipitation effects during media treatment and very modest shifts in pH values observed indicated sufficient compatibility of the formulations evaluated with the HTST-processing conditions. Unsupervised chemometric analysis of LC-MS/MS data, however, revealed clear separation of HTST-treated samples from untreated counterparts as observed from analysis of principal components and hierarchical clustering sample grouping. An increased presence of Maillard products in HTST-treated formulations contributed to the observed differences which included organic acids, observed particularly in chemically defined formulations, and furans, pyridines, pyrazines, and pyrrolidines which were determined in hydrolysate-supplemented formulations. The presence of Maillard products in media did not affect cell culture performance with similar growth and viability profiles observed for CHO-K1 and CHO-DP12 cells when cultured using both HTST-treated and untreated media formulations.

  20. Electromagnetic-Thermal Integrated Design Optimization for Hypersonic Vehicle Short-Time Duty PM Brushless DC Motor

    Directory of Open Access Journals (Sweden)

    Quanwu Li

    2016-01-01

    Full Text Available High reliability is required for the permanent magnet brushless DC motor (PM-BLDCM in an electrical pump of hypersonic vehicle. The PM-BLDCM is a short-time duty motor with high-power-density. Since thermal equilibrium is not reached for the PM-BLDCM, the temperature distribution is not uniform and there is a risk of local overheating. The winding is a main heat source and its insulation is thermally sensitive, so reducing the winding temperature rise is the key to the improvement of the reliability. In order to reduce the winding temperature rise, an electromagnetic-thermal integrated design optimization method is proposed. The method is based on electromagnetic analysis and thermal transient analysis. The requirements and constraints of electromagnetic and thermal design are considered in this method. The split ratio and the maximum flux density in stator lamination, which are highly relevant to the windings temperature rise, are optimized analytically. The analytical results are verified by finite element analysis (FEA and experiments. The maximum error between the analytical and the FEA results is 4%. The errors between the analytical and measured windings temperature rise are less than 8%. It can be proved that the method can obtain the optimal design accurately to reduce the winding temperature rise.

  1. On board short-time high temperature heat treatment of ballast water: a field trial under operational conditions.

    Science.gov (United States)

    Quilez-Badia, Gemma; McCollin, Tracy; Josefsen, Kjell D; Vourdachas, Anthony; Gill, Margaret E; Mesbahi, Ehsan; Frid, Chris L J

    2008-01-01

    A ballast water short-time high temperature heat treatment technique was applied on board a car-carrier during a voyage from Egypt to Belgium. Ballast water from three tanks was subjected for a few seconds to temperatures ranging from 55 degrees C to 80 degrees C. The water was heated using the vessel's heat exchanger steam and a second heat exchanger was used to pre-heat and cool down the water. The treatment was effective at causing mortality of bacteria, phytoplankton and zooplankton. The International Maritime Organization (IMO) standard was not agreed before this study was carried out, but comparing our results gives a broad indication that the IMO standard would have been met in some of the tests for the zooplankton, in all the tests for the phytoplankton; and probably on most occasions for the bacteria. Passing the water through the pump increased the kill rate but increasing the temperature above 55 degrees C did not improve the heat treatment's efficacy.

  2. [Real-time quantification to analyze historical Colombian samples detecting a short fragment of hypervariable region II of mitochondrial DNA].

    Science.gov (United States)

    Pérez, Luz Adriana; Rodríguez, Freddy; Langebaek, Carl Henrik; Groot, Helena

    2016-09-01

    Unlike other molecular biology studies, the analysis of ancient DNA (aDNA) requires special infrastructure and methodological conditions to guarantee the quality of the results. One of the main authenticity criteria is DNA quantification, where quantitative real-time PCR is often used given its sensitivity and specificity. Nevertheless, the implementation of these conditions and methodologies to fulfill authenticity criteria imply higher costs. Objective: To develop a simple and less costly method for mitochondrial DNA quantification suitable for highly degraded samples. Materials and methods: The proposed method is based on the use of mini-primers for the specific amplification of short fragments of mitochondrial DNA. The subsequent purification of these amplified fragments allows a standard curve to be constructed with concentrations in accordance to the state of degradation of the samples. Results: The proposed method successfully detected DNA from ancient samples including bone remains and mummified tissue. DNA inhibitory substances were also detected. Conclusion: The proposed method represents a simpler and cost-effective way to detect low amounts of aDNA, and a tool to differentiate DNA-free samples from samples with inhibitory substances.

  3. Definition of the applicability domain of the Short Time Exposure (STE) test for predicting the eye irritation of chemicals.

    Science.gov (United States)

    Hayashi, Kazuhiko; Abo, Takayuki; Nukada, Yuko; Sakaguchi, Hitoshi

    2013-05-01

    The Short Time Exposure (STE) test is a simple and easy-to-perform in vitro eye irritation test, that uses the viability of SIRC cells (a rabbit corneal cell line) treated for five minutes as the endpoint. In this study, our goal was to define the applicability domain of the STE test, based on the results obtained with a set of 113 substances. To achieve this goal, chemicals were selected to represent both different chemical classes and different chemical properties, as well as to cover, in a balanced manner, the categories of eye irritation potential according to the Globally Harmonised System (GHS). Accuracy analysis indicated that the rates of false negatives for organic/inorganic salts (75.0%), hydrocarbons (33.3%) and alcohols (23.5%) were high. Many of the false negative results were for solid substances. It is noteworthy that no surfactant resulted in a false negative result in the STE test. Further examination of the physical property data and performance showed a significant improvement in the predictive accuracy, when substances with vapour pressures over 6kPa were excluded from the analyses. Our results indicate that several substances - i.e. certain solids such as salts, alcohols, hydrocarbons, and volatile substances with a vapour pressure over 6kPa - do not fall within the applicability domain of the STE test. Overall, we are encouraged by the performance and improved accuracy of the STE test. 2013 FRAME.

  4. PLLA-PHB fiber membranes obtained by solvent-free electrospinning for short-time drug delivery.

    Science.gov (United States)

    Cao, K; Liu, Y; Olkhov, A A; Siracusa, V; Iordanskii, A L

    2018-02-01

    Fibers of poly(L-lactic acid) (PLLA)/polyhydroxybutyrate (PHB) with different concentrations of the drug dipyridamole (DPD) were prepared using solvent-free melt electrospinning to obtain a polymeric drug delivery system. The electrospun fibers were morphologically, structurally, thermally, and dynamically characterized. Crazes that resemble lotus root crevices were interestingly observed in the 7:3 PLLA/PHB fibers with 1% DPD. The crystallinity of PLLA slightly decreased as PHB was incorporated, and the addition of DPD significantly reduced the melting temperature of the composite. The interactions between PLLA and PHB mainly occurred at a proportion of 7:3, and drug encapsulation in the fibers was verified. The kinetic profiles of drug release demonstrated the predominant multiple patterns involving a diffusional stage in the short-term mode of release and kinetic process related to the hydrolysis of the biopolymers. Furthermore, the dynamic behavior of the polymer molecules was evaluated based on the segmental mobility using probe electron spin resonance spectroscopy. The segmental mobility in the amorphous fraction of PLLA decreased with increasing PLLA content. The 9:1 PLLA/PHB system was more resistant to polymer hydrolysis than to the 7:3 system and the rate of diffusion transport was approximately two times higher for the 7:3 PLLA/PHB fibers than for the 9:1 PLLA/PHB fibers.

  5. Short repetition time multiband echo-planar imaging with simultaneous pulse recording allows dynamic imaging of the cardiac pulsation signal.

    Science.gov (United States)

    Tong, Yunjie; Hocke, Lia M; Frederick, Blaise deB

    2014-11-01

    Recently developed simultaneous multislice echo-planar imaging (EPI) sequences permit imaging of the whole brain at short repetition time (TR), allowing the cardiac fluctuations to be fully sampled in blood-oxygen-level dependent functional MRI (BOLD fMRI). A novel low computational analytical method was developed to dynamically map the passage of the pulsation signal through the brain and visualize the whole cerebral vasculature affected by the pulse signal. This algorithm is based on a simple combination of fast BOLD fMRI and the scanner's own built-in pulse oximeter. Multiple, temporally shifted copies of the pulse oximeter data (with 0.08 s shifting step and coverage of a 1-s span) were downsampled and used as cardiac pulsation regressors in a general linear model based analyses (FSL) of the fMRI data. The resulting concatenated z-statistics maps show the voxels that are affected as the cardiac signal travels through the brain. Many voxels were highly correlated with the pulsation regressor or its temporally shifted version. The dynamic and static cardiac pulsation maps obtained from both the task and resting state scans, resembled cerebral vasculature. The results demonstrated: (i) cardiac pulsation significantly affects most voxels in the brain; (ii) combining fast fMRI and this analytical method can reveal additional clinical information to functional studies. Copyright © 2013 Wiley Periodicals, Inc.

  6. Role of radiation chemical and enzymatic processes on single-strand breaks at short times after irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Sapora, O; Loverock, P S; Fielden, E M [Institute of Cancer Research, Sutton (UK). Surrey Branch

    1976-10-01

    A rapid mixing lysis technique has been used to study the effects of irradiation at different temperatures on two strains of E.coli K12, one lacking in the polymerase I activity (W3110), and the other carrying a ligase temperature-sensitive mutation (DY179), which had full ligase activity at 30/sup 0/C and none at 46/sup 0/C. The results provided direct evidence for the absence of any ligase-dependent repair of SSB at short times. The addition of 5 x 10/sup -3/M cysteine to heat-treated W3110 cells before irradiation in anoxic conditions practically removed the increase in yield of SSB per single strand genome shown by the heat-treated cells; the response was very close to that of normal cells in anoxia. The important contribution of sulphydryl compounds to the anoxic radio-biological response is thereby demonstrated. The basic difference in damage obtained by irradiation under oxic or anoxic conditions is due not to preferential enzymic (ligase) repair but to differences in radiation chemical events.

  7. Adding functionality with additive manufacturing: Fabrication of titanium-based antibiotic eluting implants

    Energy Technology Data Exchange (ETDEWEB)

    Cox, Sophie C. [School of Chemical Engineering, University of Birmingham, Edgbaston B15 2TT (United Kingdom); Jamshidi, Parastoo [School of Materials and Metallurgy, University of Birmingham, Edgbaston B15 2TT (United Kingdom); Eisenstein, Neil M. [School of Chemical Engineering, University of Birmingham, Edgbaston B15 2TT (United Kingdom); Royal Centre for Defence Medicine, Birmingham Research Park, Vincent Drive, Edgbaston B15 2SQ (United Kingdom); Webber, Mark A. [School of Biosciences, University of Birmingham, Edgbaston B15 2TT (United Kingdom); Hassanin, Hany [School of Materials and Metallurgy, University of Birmingham, Edgbaston B15 2TT (United Kingdom); School of Mechanical and Automotive Engineering, Kingston University, London SW15 3DW (United Kingdom); Attallah, Moataz M. [School of Materials and Metallurgy, University of Birmingham, Edgbaston B15 2TT (United Kingdom); Shepherd, Duncan E.T. [Department of Mechanical Engineering, School of Engineering, University of Birmingham, Edgbaston B15 2TT (United Kingdom); Addison, Owen [School of Dentistry, University of Birmingham, Edgbaston B15 2TT (United Kingdom); Grover, Liam M. [School of Chemical Engineering, University of Birmingham, Edgbaston B15 2TT (United Kingdom)

    2016-07-01

    Additive manufacturing technologies have been utilised in healthcare to create patient-specific implants. This study demonstrates the potential to add new implant functionality by further exploiting the design flexibility of these technologies. Selective laser melting was used to manufacture titanium-based (Ti-6Al-4V) implants containing a reservoir. Pore channels, connecting the implant surface to the reservoir, were incorporated to facilitate antibiotic delivery. An injectable brushite, calcium phosphate cement, was formulated as a carrier vehicle for gentamicin. Incorporation of the antibiotic significantly (p = 0.01) improved the compressive strength (5.8 ± 0.7 MPa) of the cement compared to non-antibiotic samples. The controlled release of gentamicin sulphate from the calcium phosphate cement injected into the implant reservoir was demonstrated in short term elution studies using ultraviolet-visible spectroscopy. Orientation of the implant pore channels were shown, using micro-computed tomography, to impact design reproducibility and the back-pressure generated during cement injection which ultimately altered porosity. The amount of antibiotic released from all implant designs over a 6 hour period (< 28% of the total amount) were found to exceed the minimum inhibitory concentrations of Staphylococcus aureus (16 μg/mL) and Staphylococcus epidermidis (1 μg/mL); two bacterial species commonly associated with periprosthetic infections. Antibacterial efficacy was confirmed against both bacterial cultures using an agar diffusion assay. Interestingly, pore channel orientation was shown to influence the directionality of inhibition zones. Promisingly, this work demonstrates the potential to additively manufacture a titanium-based antibiotic eluting implant, which is an attractive alternative to current treatment strategies of periprosthetic infections. - Highlights: • Titanium implants were additively manufactured with surface connected reservoirs. • Implants

  8. Drug-eluting Ti wires with titania nanotube arrays for bone fixation and reduced bone infection

    Science.gov (United States)

    Gulati, Karan; Aw, Moom Sinn; Losic, Dusan

    2011-10-01

    Current bone fixation technology which uses stainless steel wires known as Kirschner wires for fracture fixing often causes infection and reduced skeletal load resulting in implant failure. Creating new wires with drug-eluting properties to locally deliver drugs is an appealing approach to address some of these problems. This study presents the use of titanium [Ti] wires with titania nanotube [TNT] arrays formed with a drug delivery capability to design alternative bone fixation tools for orthopaedic applications. A titania layer with an array of nanotube structures was synthesised on the surface of a Ti wire by electrochemical anodisation and loaded with antibiotic (gentamicin) used as a model of bone anti-bacterial drug. Successful fabrication of TNT structures with pore diameters of approximately 170 nm and length of 70 μm is demonstrated for the first time in the form of wires. The drug release characteristics of TNT-Ti wires were evaluated, showing a two-phase release, with a burst release (37%) and a slow release with zero-order kinetics over 11 days. These results confirmed our system's ability to be applied as a drug-eluting tool for orthopaedic applications. The established biocompatibility of TNT structures, closer modulus of elasticity to natural bones and possible inclusion of desired drugs, proteins or growth factors make this system a promising alternative to replace conventional bone implants to prevent bone infection and to be used for targeted treatment of bone cancer, osteomyelitis and other orthopaedic diseases.

  9. Correlating cytotoxicity to elution behaviors of composite resins in term of curing kinetic.

    Science.gov (United States)

    Meng, Junquan; Yang, Huichuan; Cao, Man; Li, Lei; Cai, Qing

    2017-09-01

    Cytotoxicity of photocurable composite resins is a key issue for their safe use in dental restoration. Curing kinetic and elution behaviors of the composite resin would have decisive effects on its cytotoxicity. In this study, composite resins composed of bisphenol-glycidyl dimethacrylate (Bis-GMA), triethyleneglycol dimethacrylate (TEGDMA), camphorquinone (CQ), N,N-dimethylaminoethyl methacrylate (DMAEMA) and barium glass powders were prepared by setting the photoinitiators CQ/DMAEMA at 0.5wt%, 1wt% or 3wt% of the total weight of Bis-GMA/TEGDMA. The ratio of Bis-GMA/TEGDMA was 6:4, the ratio of CQ/DMAEMA was 1:1, and the incorporated inorganic powder was 75wt%. Then, curing kinetics were studied by using real-time Fourier transform infrared spectroscopy (FTIR) and photo-DSC (differential scanning calorimeter). Elution behaviors in both ethanol solution and deionized water were monitored by using liquid chromatogram/mass spectrometry (LC/MS). Cytotoxicity was evaluated by in vitro culture of L929 fibroblasts. Finally, they were all analyzed and correlated in terms of initiator contents. It was found that the commonly used 0.5wt% of photoinitiators was somewhat insufficient in obtaining composite resin with low cytotoxicity. Copyright © 2017. Published by Elsevier B.V.

  10. On the time course of short-term forgetting: a human experimental model for the sense of balance.

    Science.gov (United States)

    Tribukait, Arne; Eiken, Ola

    2016-02-01

    The primary aim of this study was to establish whether the decline of the memory of an angular displacement, detected by the semicircular canals, is best characterized by an exponential function or by a power function. In 27 subjects a conflict was created between the semicircular canals and the graviceptive systems. Subjects were seated, facing forwards, in the gondola of a large centrifuge. The centrifuge was accelerated from stationary to 2.5Gz. While the swing out of the gondola (66°) during acceleration constitutes a frontal plane angular-displacement stimulus to the semicircular canals, the graviceptive systems persistently signal that the subject is upright. During 6 min at 2.5Gz the perceived head and body position was recorded; in darkness the subject repeatedly adjusted the orientation of a luminous line so that it appeared to be horizontal. Acceleration of the centrifuge induced a sensation of tilt which declined with time in a characteristic way. A three-parameter exponential function (Y = Ae(-bt) + C) and a power function (Y = At(-b) + C) were fitted to the data points. The inter-individual variability was considerable. In the vast majority of cases, however, the exponential function provided a better fit (in terms of RMS error) than the power function. The mean exponential function was: y = 27.8e(-0.018t) + 0.5°, where t is time in seconds. Findings are discussed with connection to possible underlying neural mechanisms; in particular, the head-direction system and short-term potentiation and persistent action potential firing in the hippocampus are considered.

  11. Short time evaluation of metallic materials' fatigue potential combining destructive and non-destructive testing methods

    International Nuclear Information System (INIS)

    Starke, Peter; Wu, Haoran; Boller, Christian

    2015-01-01

    Fatigue of engineering structures is an issue from an engineering design point. The lifetime of materials being subject to repeated mechanical loads is limited. Different examples of failures and fateful air accidents have caused significant cost and claims to the operators as well as manufacturers in excess of fatalities. Criticality of failure increases with increasing age and the uncertainty of operational loads applied. In such a case a reassessment of a structural materials' condition is in big need should damage tolerance criteria still be met, being the essential ground rule for aeronautical structural design. It is therefore the challenging aim to use a metallic material's microstructure characterizing non-destructive testing (NDT) parameter or a combination of those as a parameter to be scanned over a defined surface of the component considered to more realistically characterize the damage condition and to use this information twofold: (a) to more precisely assess the structural component's residual life and (b) to feed the information recorded back into a specific database belonging to an approach named PHYBAL. The physically based fatigue life evaluation method (PHYBAL) is a short-time procedure for the evaluation of fatigue data based on a small number of fatigue tests performed on un-notched specimens only. This method significantly reduces the effort for experimentation in terms of time and cost by around 90 % and inhibits remarkable scientific as well as economic advantages. The paper highlights the high capability of PHYBAL as well as the suitability for assessing the residual life of aeronautical components also with respect to the application of this approach in the light of structural health monitoring issues.

  12. Time-lapse ERT and DTS for seasonal and short-term monitoring of an alpine river hyporheic zone

    Science.gov (United States)

    Boaga, Jacopo; Laura, Busato; Mariateresa, Perri; Giorgio, Cassiani

    2016-04-01

    The hyporheic zone (HZ) is the area located beneath and adjacent to rivers and streams, where the interactions between surface water and groundwater take place. This complex physical domain allows the transport of several substances from a stream to the unconfined aquifer below, and vice versa, thus playing a fundamental role in the river ecosystem. The importance of the hyporheic zone makes its characterization a goal shared by several disciplines, which range from applied geophysics to biogeochemistry, from hydraulics to ecology. The frontier field of HZ characterization stays in applied non-invasive methodologies as Electrical Resistivity Tomography - ERT - and Distributed Temperature Sensing - DTS. ERT is commonly applied in cross-well configuration or with a superficial electrodes deployment while DTS is used in hydro-geophysics in the last decade, revealing a wide applicability to the typical issues of this field of study. DTS for hydro-geophysics studies is based on Raman scattering and employs heat as tracer and uses a fiber-optic cable to acquire temperature values. We applied both techniques for an alpine river case studies located in Val di Sole, TN, Italy. The collected measurements allow high-resolution characterization of the hyporheic zone, overcoming the critical problem of invasive measurements under riverbeds. In this work, we present the preliminary results regarding the characterization of the hyporheic zone of the alpine river obtained combining ERT and DTS time-lapse measurements. The data collection benefits from an innovative instrumentation deployment, which consists of both an ERT multicore cable and a DTS fiber-optic located in two separated boreholes drilled 5m under the watercourse and perpendicular to it. In particular we present the first year monitoring results and a short time-lapse monitoring experiment conducted during summer 2015. The site and the results here described are part of the EU FP7 CLIMB (Climate Induced Changes on the

  13. High-Temperature Short-Time Pasteurization System for Donor Milk in a Human Milk Bank Setting

    Directory of Open Access Journals (Sweden)

    Diana Escuder-Vieco

    2018-05-01

    Full Text Available Donor milk is the best alternative for the feeding of preterm newborns when mother's own milk is unavailable. For safety reasons, it is usually pasteurized by the Holder method (62.5°C for 30 min. Holder pasteurization results in a microbiological safe product but impairs the activity of many biologically active compounds such as immunoglobulins, enzymes, cytokines, growth factors, hormones or oxidative stress markers. High-temperature short-time (HTST pasteurization has been proposed as an alternative for a better preservation of some of the biological components of human milk although, at present, there is no equipment available to perform this treatment under the current conditions of a human milk bank. In this work, the specific needs of a human milk bank setting were considered to design an HTST equipment for the continuous and adaptable (time-temperature combination processing of donor milk. Microbiological quality, activity of indicator enzymes and indices for thermal damage of milk were evaluated before and after HTST treatment of 14 batches of donor milk using different temperature and time combinations and compared to the results obtained after Holder pasteurization. The HTST system has accurate and simple operation, allows the pasteurization of variable amounts of donor milk and reduces processing time and labor force. HTST processing at 72°C for, at least, 10 s efficiently destroyed all vegetative forms of microorganisms present initially in raw donor milk although sporulated Bacillus sp. survived this treatment. Alkaline phosphatase was completely destroyed after HTST processing at 72 and 75°C, but γ-glutamil transpeptidase showed higher thermoresistance. Furosine concentrations in HTST-treated donor milk were lower than after Holder pasteurization and lactulose content for HTST-treated donor milk was below the detection limit of analytical method (10 mg/L. In conclusion, processing of donor milk at 72°C for at least 10 s in

  14. High-Temperature Short-Time Pasteurization System for Donor Milk in a Human Milk Bank Setting.

    Science.gov (United States)

    Escuder-Vieco, Diana; Espinosa-Martos, Irene; Rodríguez, Juan M; Corzo, Nieves; Montilla, Antonia; Siegfried, Pablo; Pallás-Alonso, Carmen R; Fernández, Leónides

    2018-01-01

    Donor milk is the best alternative for the feeding of preterm newborns when mother's own milk is unavailable. For safety reasons, it is usually pasteurized by the Holder method (62.5°C for 30 min). Holder pasteurization results in a microbiological safe product but impairs the activity of many biologically active compounds such as immunoglobulins, enzymes, cytokines, growth factors, hormones or oxidative stress markers. High-temperature short-time (HTST) pasteurization has been proposed as an alternative for a better preservation of some of the biological components of human milk although, at present, there is no equipment available to perform this treatment under the current conditions of a human milk bank. In this work, the specific needs of a human milk bank setting were considered to design an HTST equipment for the continuous and adaptable (time-temperature combination) processing of donor milk. Microbiological quality, activity of indicator enzymes and indices for thermal damage of milk were evaluated before and after HTST treatment of 14 batches of donor milk using different temperature and time combinations and compared to the results obtained after Holder pasteurization. The HTST system has accurate and simple operation, allows the pasteurization of variable amounts of donor milk and reduces processing time and labor force. HTST processing at 72°C for, at least, 10 s efficiently destroyed all vegetative forms of microorganisms present initially in raw donor milk although sporulated Bacillus sp. survived this treatment. Alkaline phosphatase was completely destroyed after HTST processing at 72 and 75°C, but γ-glutamil transpeptidase showed higher thermoresistance. Furosine concentrations in HTST-treated donor milk were lower than after Holder pasteurization and lactulose content for HTST-treated donor milk was below the detection limit of analytical method (10 mg/L). In conclusion, processing of donor milk at 72°C for at least 10 s in this HTST system

  15. High-Temperature Short-Time Pasteurization System for Donor Milk in a Human Milk Bank Setting

    Science.gov (United States)

    Escuder-Vieco, Diana; Espinosa-Martos, Irene; Rodríguez, Juan M.; Corzo, Nieves; Montilla, Antonia; Siegfried, Pablo; Pallás-Alonso, Carmen R.; Fernández, Leónides

    2018-01-01

    Donor milk is the best alternative for the feeding of preterm newborns when mother's own milk is unavailable. For safety reasons, it is usually pasteurized by the Holder method (62.5°C for 30 min). Holder pasteurization results in a microbiological safe product but impairs the activity of many biologically active compounds such as immunoglobulins, enzymes, cytokines, growth factors, hormones or oxidative stress markers. High-temperature short-time (HTST) pasteurization has been proposed as an alternative for a better preservation of some of the biological components of human milk although, at present, there is no equipment available to perform this treatment under the current conditions of a human milk bank. In this work, the specific needs of a human milk bank setting were considered to design an HTST equipment for the continuous and adaptable (time-temperature combination) processing of donor milk. Microbiological quality, activity of indicator enzymes and indices for thermal damage of milk were evaluated before and after HTST treatment of 14 batches of donor milk using different temperature and time combinations and compared to the results obtained after Holder pasteurization. The HTST system has accurate and simple operation, allows the pasteurization of variable amounts of donor milk and reduces processing time and labor force. HTST processing at 72°C for, at least, 10 s efficiently destroyed all vegetative forms of microorganisms present initially in raw donor milk although sporulated Bacillus sp. survived this treatment. Alkaline phosphatase was completely destroyed after HTST processing at 72 and 75°C, but γ-glutamil transpeptidase showed higher thermoresistance. Furosine concentrations in HTST-treated donor milk were lower than after Holder pasteurization and lactulose content for HTST-treated donor milk was below the detection limit of analytical method (10 mg/L). In conclusion, processing of donor milk at 72°C for at least 10 s in this HTST system

  16. Time- and Dose-Dependent Effects of 17 Beta-Estradiol on Short-Term, Real-Time Proliferation and Gene Expression in Porcine Granulosa Cells

    Directory of Open Access Journals (Sweden)

    Sylwia Ciesiółka

    2017-01-01

    Full Text Available The key mechanisms responsible for achievement of full reproductive and developmental capability in mammals are the differentiation and transformation of granulosa cells (GCs during folliculogenesis, oogenesis, and oocyte maturation. Although the role of 17 beta-estradiol (E2 in ovarian activity is widely known, its effect on proliferative capacity, gap junction connection (GJC formation, and GCs-luteal cells transformation requires further research. Therefore, the goal of this study was to assess the real-time proliferative activity of porcine GCs in vitro in relation to connexin (Cx, luteinizing hormone receptor (LHR, follicle stimulating hormone receptor (FSHR, and aromatase (CYP19A1 expression during short-term (168 h primary culture. The cultured GCs were exposed to acute (at 96 h of culture and/or prolonged (between 0 and 168 h of culture administration of 1.8 and 3.6 μM E2. The relative abundance of Cx36, Cx37, Cx40, Cx43, LHR, FSHR, and CYP19A1 mRNA was measured. We conclude that the proliferation capability of GCs in vitro is substantially associated with expression of Cxs, LHR, FSHR, and CYP19A1. Furthermore, the GC-luteal cell transformation in vitro may be significantly accompanied by the proliferative activity of GCs in pigs.

  17. Studies of post-elution concentration of 99m-Tc eluted from a gel type chromatographic generator

    International Nuclear Information System (INIS)

    Suzuki, Katia N.; Osso Junior, Joao Alberto

    2007-01-01

    The radiopharmaceuticals most used in Diagnostic Nuclear Medicine are those labeled with the metastable technetium ( 99m Tc) due to its ideal physical properties of decay (t 1/2 6.01 h, Eγ 140 keV), low cost and availability facilitated through the commercial generator 99 Mo / 99m Tc. This radionuclide is formed by the β - decay of 99 Mo adsorbed on an alumina column of the generator and collected in the form of sodium pertechnetate (Na 99m TcO 4 ) by elution with saline solution (0.9%). The Radiopharmacy Center (CR) of the IPEN-CNEN/SP developed a gel type chromatographic generator of MoZr with 99 Mo produced by 98 Mo(n, γ) 99 Mo reaction that occurs in IEA-R1 Nuclear Reactor. The gel is composed of zirconium molybdate with elution volume of 12 ml with an activity of 11100 MBq (300 mCi) producing a radioactive concentration of 925 MBq (34 mCi) / ml. The fission generator gives a higher radioactive concentration around 1850 MBq (69 mCi) / ml. The aim of this work is to study a system of post-elution concentration using ion exchange cartridges in tandem (cation - anion) for the attainment of a high enough radioactive concentration to meet the demand of market, with a proved quality. This system of concentration will be made based in the technique of solid phase extraction (SPE) using commercial cartridges of extraction, which contains the solid phase and eluent saline solution (0.9%). As the eluent results of this system used in the gel generator of MoZr will be compared with the fission generator currently produced by IPEN-CNEN/SP. (author)

  18. Studies of post-elution concentration of {sup 99m}-Tc eluted from a gel type chromatographic generator

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Katia N.; Osso Junior, Joao Alberto [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)]. E-mail: norisuzuki6@yahoo.com.br; jaosso@ipen.br

    2007-07-01

    The radiopharmaceuticals most used in Diagnostic Nuclear Medicine are those labeled with the metastable technetium ({sup 99m}Tc) due to its ideal physical properties of decay (t{sub 1/2} 6.01 h, E{gamma} 140 keV), low cost and availability facilitated through the commercial generator {sup 99}Mo /{sup 99m}Tc. This radionuclide is formed by the {beta}{sup -} decay of {sup 99}Mo adsorbed on an alumina column of the generator and collected in the form of sodium pertechnetate (Na{sup 99m}TcO{sub 4}) by elution with saline solution (0.9%). The Radiopharmacy Center (CR) of the IPEN-CNEN/SP developed a gel type chromatographic generator of MoZr with {sup 99}Mo produced by {sup 98}Mo(n, {gamma}){sup 99}Mo reaction that occurs in IEA-R1 Nuclear Reactor. The gel is composed of zirconium molybdate with elution volume of 12 ml with an activity of 11100 MBq (300 mCi) producing a radioactive concentration of 925 MBq (34 mCi) / ml. The fission generator gives a higher radioactive concentration around 1850 MBq (69 mCi) / ml. The aim of this work is to study a system of post-elution concentration using ion exchange cartridges in tandem (cation - anion) for the attainment of a high enough radioactive concentration to meet the demand of market, with a proved quality. This system of concentration will be made based in the technique of solid phase extraction (SPE) using commercial cartridges of extraction, which contains the solid phase and eluent saline solution (0.9%). As the eluent results of this system used in the gel generator of MoZr will be compared with the fission generator currently produced by IPEN-CNEN/SP. (author)

  19. Safety and efficacy of limus-eluting stents and balloon angioplasty for sirolimus-eluting in-stent restenosis

    Energy Technology Data Exchange (ETDEWEB)

    Ota, Hideaki [Division of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC 20010 (United States); Mahmoudi, Michael [University of Surrey, Guildford Road, Surrey, GU2-7XH (United Kingdom); Kitabata, Hironori; Torguson, Rebecca; Chen, Fang; Satler, Lowell F.; Suddath, William O.; Pichard, Augusto D. [Division of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC 20010 (United States); Waksman, Ron, E-mail: ron.waksman@medstar.net [Division of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC 20010 (United States)

    2015-03-15

    Objectives: The aim of this study was to compare the safety and efficacy of everolimus-eluting stent (EES), sirolimus-eluting stent (SES), and plain old balloon angioplasty (POBA) for the treatment of SES in-stent restenosis (S-ISR). Background: The optimal treatment for drug-eluting in-stent restenosis remains controversial. Methods: The study cohort comprised 310 consecutive patients (444 lesions) who presented with S-ISR to our institution and underwent treatment with EES (43 patients), SES (102), or POBA (165). The analyzed clinical parameters were the 1-year rates of death, Q-wave myocardial infarction (MI), target lesion revascularization (TLR), target vessel revascularization (TVR), definite stent thrombosis (ST) and major adverse cardiac event (MACE) defined as the composite of death, MI, or TLR at 1-year. Results: The three groups were well matched for the conventional risk factors for coronary artery disease except for smoking. The 1-year analyzed clinical parameters were similar in the three groups: MACE (EES = 14%, SES = 18%, POBA = 20%; p = 0.65), death (EES = 2.3%, SES = 6.2%, POBA = 6.1%; p = 0.61), MI (EES = 4.8%, SES = 2.1%, POBA = 2.5%; p = 0.69), TLR (EES = 11.9%, SES = 12.1%, POBA = 24%; p = 0.78), and TVR (EES = 11.9%, SES = 24.8%, POBA = 22.2%; p = 0.23). There were no cases of definite ST. MACE-free rate was significantly lower in patients with recurrent in-stent restenosis (log-rank p = 0.006). Presentation with acute MI, number of treated lesions and a previous history of MI were found to be independent predictors of MACE. Conclusions: In patients presenting with S-ISR, treatment with implantation of an EES, SES, or POBA is associated with similar clinical outcomes. Patients presenting with recurrent ISR may have a poorer clinical outcome.

  20. Short term protein supplementation during a long interval prostaglandin-based protocol for timed AI in sheep.

    Science.gov (United States)

    Errandonea, N; Fierro, S; Viñoles, C; Gil, J; Banchero, G; Olivera-Muzante, J

    2018-03-21

    The aim of this study was to evaluate the reproductive impact of a short-term protein supplementation on a long interval prostaglandin-based protocol (two PG injections 15 d apart; PG15) for timed artificial insemination in sheep. During the breeding season, 437 multiparous Merino ewes grazing native pastures (forage allowance of 6 kg of dry matter/100 kg of live weight; crude protein: 10.8%, metabolic energy: 2.1 Mcal/kg of dry matter) were selected. Ewes were allocated, according to body condition score (3.2 ± 0.2) and body weight (40.6 ± 4.9 kg, mean ± SD), to a 2 × 2 factorial design: type of estrus -spontaneous estrus (SE) or induced with PG15 (PG15)-, and supplementation (yes or no) before insemination (+FF; soybean meal at Days -10 to -3; crude protein: 51.9%, metabolic energy: 2.8 Mcal/kg of dry matter; average consumption 0.9% live weight/ewe/day of dry matter). All ewes were cervically artificial inseminated (Day -2 to -3 in SE ewes at estrus detection; Day 0 = timed artificial insemination in PG15 ewes). Ovulation rate on Day 7, non-return to service on Day 23, conception, fertility, prolificacy and fecundity on Day 60 were evaluated. Ovulation rate (1.17 ± 0.40 vs. 1.06 ± 0.25), non-return to service at Day 23 (81.7 vs. 64.2%), conception (78.8 vs. 61.5%), fertility (75.2 vs. 61.5%) and fecundity (0.77 vs. 0.62) were higher in ewes from SE than PG15 group (P  0.05). Protein supplementation increased ovulation rate (1.30 ± 0.45 vs. 1.17 ± 0.40), prolificacy (1.18 ± 0.39 vs. 1.02 ± 0.16) and fecundity (0.94 vs. 0.77%; P conception (82.9 vs. 78.8%) or fertility (79.1 vs. 75.2%; P > 0.05) in SE group. The supplement feed to PG15 ewes increased ovulation rate (1.35 ± 0.45 vs. 1.06 ± 0.25), prolificacy (1.25 ± 0.43 vs. 1.01 ± 0.12) and fecundity (0.79 vs. 0.62%; P  0.05). The magnitude of the increase in ovulation rate in PG15 was greater than in the SE group (27 vs. 11%; P conception (63.3 vs 61

  1. Advantages and disadvantages of biodegradable platforms in drug eluting stents.

    Science.gov (United States)

    Rodriguez-Granillo, Agustina; Rubilar, Bibiana; Rodriguez-Granillo, Gaston; Rodriguez, Alfredo E

    2011-03-26

    Coronary angioplasty with drug-eluting stent (DES) implantation is currently the most common stent procedure worldwide. Since the introduction of DES, coronary restenosis as well as the incidence of target vessel and target lesion revascularization have been significantly reduced. However, the incidence of very late stent thrombosis beyond the first year after stent deployment has more commonly been linked to DES than to bare-metal stent (BMS) implantation. Several factors have been associated with very late stent thrombosis after DES implantation, such as delayed healing, inflammation, stent mal-apposition and endothelial dysfunction. Some of these adverse events were associated with the presence of durable polymers, which were essential to allow the elution of the immunosuppressive drug in the first DES designs. The introduction of erodable polymers in DES technology has provided the potential to complete the degradation of the polymer simultaneously or immediately after the release of the immunosuppressive drug, after which a BMS remains in place. Several DES designs with biodegradable (BIO) polymers have been introduced in preclinical and clinical studies, including randomized trials. In this review, we analyze the clinical results from 6 observational and randomized studies with BIO polymers and discuss advantages and disadvantages of this new technology.

  2. Intimal hyperplasia and vascular remodeling after everolimus-eluting and sirolimus-eluting stent implantation in diabetic patients the randomized diabetes and drug-eluting stent (DiabeDES) IV intravascular ultrasound trial

    DEFF Research Database (Denmark)

    Antonsen, Lisbeth; Maeng, Michael; Thayssen, Per

    2013-01-01

    OBJECTIVE: To evaluate the effects of the everolimus-eluting Xience™/Promus™ stent (EES) and the sirolimus-eluting Cypher™ stent (SES) on intimal hyperplasia (IH) in diabetic patients. BACKGROUND: Patients with diabetes mellitus have increased risk of in-stent restenosis after coronary stent...... implantation due to intimal hyperplasia (IH). METHODS: In a sub study of the Randomized Comparison of Everolimus-Eluting and Sirolimus-Eluting Stents in Patients Treated with Percutaneous Coronary Intervention (SORT OUT IV trial), serial intravascular ultrasound (IVUS) 10-month follow-up data were available...... in 88 patients, including 48 EES and 40 SES treated patients. IVUS endpoints included IH volume, in-stent % volume obstruction and changes in external elastic membrane (EEM) volume. RESULTS: Compared with the SES group, IH volume was increased in the EES group [median (interquartile range): 2.8 mm(3) (0...

  3. Separation of light lanthanons by ion exchange with ammonium acetate. Pt. 2. The influence of the conditions of elution on separation efficiency

    International Nuclear Information System (INIS)

    Hubicka, H.; Hubicki, W.

    1980-01-01

    The influence of concentration, pH of ammonium acetate, reaction rate, temperature, the way of chromatogram development and composition of being separated mixture upon effective distribution of light lanthanons were studied. The elution for pH 6.8 - 7.0 gives the maximum of eluent concentrations. The decrease of pH and of the initial eluent concentration may give better distributions at longer time of elution. The elution by means of ammonium acetate without yttrium in the light lanthanons concentrate may give Nd 2 O 3 of purity 99,9%. The increase of temperature (70 - 80 0 C) and the addition of ammonium salts to eluent influence unprofitably the distribution. (author)

  4. Preparatory Body State before Reacting to an Opponent: Short-Term Joint Torque Fluctuation in Real-Time Competitive Sports.

    Science.gov (United States)

    Fujii, Keisuke; Yamashita, Daichi; Kimura, Tetsuya; Isaka, Tadao; Kouzaki, Motoki

    2015-01-01

    In a competitive sport, the outcome of a game is determined by an athlete's relationship with an unpredictable and uncontrolled opponent. We have previously analyzed the preparatory state of ground reaction forces (GRFs) dividing non-weighted and weighted states (i.e., vertical GRFs below and above 120% of body weight, respectively) in a competitive ballgame task and demonstrated that the non-weighted state prevented delay of the defensive step and promoted successful guarding. However, the associated kinetics of lower extremity joints during a competitive sports task remains unknown. The present study aims to investigate the kinetic characteristics of a real-time competitive sport before movement initiation. As a first kinetic study on a competitive sport, we initially compared the successful defensive kinetics with a relatively stable preparatory state and the choice-reaction sidestep as a control movement. Then, we investigated the kinetic cause of the outcome in a 1-on-1 dribble in terms of the preparatory states according to our previous study. The results demonstrated that in successful defensive motions in the non-weighted state guarding trial, the times required for the generation of hip abduction and three extension torques for the hip, knee, and ankle joints were significantly shortened compared with the choice-reaction sidestep, and hip abduction and hip extension torques were produced almost simultaneously. The sport-specific movement kinetics emerges only in a more-realistic interactive experimental setting. A comparison of the outcomes in the 1-on-1 dribble and preparatory GRF states showed that, in the non-weighted state, the defenders guarded successfully in 68.0% of the trials, and the defender's initiation time was earlier than that in the weighted state (39.1%). In terms of kinetics, the root mean squares of the derivative of hip abduction and three extension torques in the non-weighted state were smaller than those in the weighted state

  5. Fast Gradient Elution Reversed-Phase HPLC with Diode-Array Detection as a High Throughput Screening Method for Drugs of Abuse

    Energy Technology Data Exchange (ETDEWEB)

    Peter W. Carr; K.M. Fuller; D.R. Stoll; L.D. Steinkraus; M.S. Pasha; Glenn G. Hardin

    2005-12-30

    A new approach has been developed by modifying a conventional gradient elution liquid chromatograph for the high throughput screening of biological samples to detect the presence of regulated intoxicants. The goal of this work was to improve the speed of a gradient elution screening method over current approaches by optimizing the operational parameters of both the column and the instrument without compromising the reproducibility of the retention times, which are the basis for the identification. Most importantly, the novel instrument configuration substantially reduces the time needed to re-equilibrate the column between gradient runs, thereby reducing the total time for each analysis. The total analysis time for each gradient elution run is only 2.8 minutes, including 0.3 minutes for column reequilibration between analyses. Retention times standard calibration solutes are reproducible to better than 0.002 minutes in consecutive runs. A corrected retention index was adopted to account for day-to-day and column-to-column variations in retention time. The discriminating power and mean list length were calculated for a library of 47 intoxicants and compared with previous work from other laboratories to evaluate fast gradient elution HPLC as a screening tool.

  6. Late lumen loss and intima hyperplasia after sirolimus-eluting and zotarolimus-eluting stent implantation in diabetic patients: the diabetes and drug-eluting stent (DiabeDES III) angiography and intravascular ultrasound trial

    DEFF Research Database (Denmark)

    Jensen, Lisette Okkels; Mæng, Michael; Thayssen, Per

    2011-01-01

    Patients with diabetes mellitus have increased risk of in-stent restenosis after coronary stent implantation due to neointimal hyperplasia (NIH). The aim of this study was to use quantitative coronary angiography (QCA) and volumetric intravascular ultrasound (IVUS) to evaluate the effects...... of the sirolimus-eluting Cypher® stent (SES) and the zotarolimus-eluting Endeavor® stent (ZES) on angiographic late lumen loss and intima hyperplasia in diabetic patients....

  7. Effect of short-term heat acclimation on endurance time and skin blood flow in trained athletes

    Directory of Open Access Journals (Sweden)

    Chen TI

    2013-06-01

    Full Text Available Tsung-I Chen,1,2 Pu-Hsi Tsai,3 Jui-Hsing Lin,4 Ning-Yuean Lee,5 Michael TC Liang61Graduate Institute of Sport Science, National Taiwan Sport University, Taoyuan, 2Center for Physical Education, Tzu Chi University, Hualien, 3Department of Sport and Leisure, National Quemoy University, Kinmen, 4Department of Physical Education, National Pingtung University of Education, Pingtung, 5College of Living Technology, Tainan University of Technology, Tainan, Taiwan; 6Department of Kinesiology and Health Promotion, California State Polytechnic University, Pomona, CA, USABackground: To examine whether short-term, ie, five daily sessions, vigorous dynamic cycling exercise and heat exposure could achieve heat acclimation in trained athletes and the effect of heat acclimation on cutaneous blood flow in the active and nonactive limb.Methods: Fourteen male badminton and table tennis athletes (age = 19.6 ± 1.2 years were randomized into a heat acclimation (EXP, n = 7 or nonheat acclimation (CON, n = 7 group. For 5 consecutive days, the EXP group was trained using an upright leg cycle ergometer in a hot environment (38.4°C ± 0.4°C, while the CON group trained in a thermoneutral environment (24.1°C ± 0.3°C. For both groups, the training intensity and duration increased from a work rate of 10% below ventilatory threshold (VT and 25 minutes per session on day 1, to 10% above VT and 45 minutes per session on day 5. Subjects performed two incremental leg cycle exercise tests to exhaustion at baseline and post-training in both hot and thermoneutral conditions. Study outcome measurements include: maximum oxygen uptake (VO2max; exercise heart rate (HR; O2 pulse; exercise time to exhaustion (tmax; skin blood flow in the upper arm (SkBFa and quadriceps (SkBFq; and mean skin (Tsk.Results: The significant heat-acclimated outcome measurements obtained during high-intensity leg cycling exercise in the high ambient environment are: (1 56%–100% reduction in cutaneous

  8. The stenting strategy of drug-eluting stents for coronary artery disease in patients on dialysis

    Directory of Open Access Journals (Sweden)

    Hiroshi Fujita

    2014-12-01

    Full Text Available Background: Reports regarding the relationship between the length and diameter of implanted drug-eluting stents and clinical and angiographic outcomes in dialysis patients are limited. Aim: We investigated the efficiency of drug-eluting stents for coronary artery disease in patients on dialysis from the viewpoint of stent sizing. Methods: Sirolimus-eluting stents were implanted in 88 lesions and bare metal stents were implanted in 43 lesions. We compared stenting strategy, major adverse cardiac events, and angiographic results between sirolimus-eluting stent and bare metal stent groups. Results: Stent diameter was smaller and stent length was longer in the sirolimus-eluting stent group than in the bare metal stent group in our routine practices. There was no significant between-group difference in late diameter loss. Rates of angiographic restenosis and target lesion revascularization were significantly higher in the sirolimus-eluting stent group than in the bare metal stent group. Although stent length was significantly longer and stent diameter was smaller in the sirolimus-eluting stent group, sirolimus-eluting stents did not improve the subsequent clinical and angiographic results compared with bare metal stents in dialysis patients. Conclusion: In dialysis patients, a longer length and/or smaller diameter sirolimus-eluting stent implantation was associated with high rates of restenosis and target lesion revascularization compared with bare metal stents.

  9. High temperature, short time pasteurization temperatures inversely affect bacterial numbers during refrigerated storage of pasteurized fluid milk.

    Science.gov (United States)

    Ranieri, M L; Huck, J R; Sonnen, M; Barbano, D M; Boor, K J

    2009-10-01

    The grade A Pasteurized Milk Ordinance specifies minimum processing conditions of 72 degrees C for at least 15 s for high temperature, short time (HTST) pasteurized milk products. Currently, many US milk-processing plants exceed these minimum requirements for fluid milk products. To test the effect of pasteurization temperatures on bacterial numbers in HTST pasteurized milk, 2% fat raw milk was heated to 60 degrees C, homogenized, and treated for 25 s at 1 of 4 different temperatures (72.9, 77.2, 79.9, or 85.2 degrees C) and then held at 6 degrees C for 21 d. Aerobic plate counts were monitored in pasteurized milk samples at d 1, 7, 14, and 21 postprocessing. Bacterial numbers in milk processed at 72.9 degrees C were lower than in milk processed at 85.2 degrees C on each sampling day, indicating that HTST fluid milk-processing temperatures significantly affected bacterial numbers in fluid milk. To assess the microbial ecology of the different milk samples during refrigerated storage, a total of 490 psychrotolerant endospore-forming bacteria were identified using DNA sequence-based subtyping methods. Regardless of processing temperature, >85% of the isolates characterized at d 0, 1, and 7 postprocessing were of the genus Bacillus, whereas more than 92% of isolates characterized at d 14 and 21 postprocessing were of the genus Paenibacillus, indicating that the predominant genera present in HTST-processed milk shifted from Bacillus spp. to Paenibacillus spp. during refrigerated storage. In summary, 1) HTST processing temperatures affected bacterial numbers in refrigerated milk, with higher bacterial numbers in milk processed at higher temperatures; 2) no significant association was observed between genus isolated and pasteurization temperature, suggesting that the genera were not differentially affected by the different processing temperatures; and 3) although typically present at low numbers in raw milk, Paenibacillus spp. are capable of growing to numbers that can

  10. Do fire severity effects on soil change in space and time in the short-term? What ash tells us

    Directory of Open Access Journals (Sweden)

    P. Pereira

    2013-05-01

    Full Text Available In the absence of data, the impact of fire, especially wildfires, is measured analysing the fire severity. This post-fire assessment is very useful because allow to identify the degree of destruction imposed by the fire. Among the techniques used to determine fire severity, ash colour is often used, that permit identify the degree of organic matter consumption (darker ash uncompleted combustion, lighter ash completed combustion. The objective of this paper was observed if fire severity changes in space and time, according to ash colour analysis, applying an index. The ash colour analysis was carried out one and fifteen days after the fire. In this area we identified ash with four different colours, black (B dark grey (DG, light gray (LG and white colour (W and some uncovered areas classified as bared soil (BS. Black and DG represent medium fire severity, LG and W, higher severity. The results showed that in the studied fire, the severity was high and a great part of the plot was uncovered by ash (BS. Fifteen days after BS increased as the fire severity index, from 6.05 to 6.45, showing that during this period the ash redistribution in a short period after the fire can influence the fire severity assessment. We did not identified significant differences between measurements and the coefficient of variation (CV% remained the same. However significant differences were identified with the spatial correlation analysis with Global Moran's I and the spatial structure of fire severity index. This is evidence that ash color changed in this period in the space and the traditional statistical methods did not detected, only with spatial analysis. The analysis of fire severity using ash color some days after the fire can induce important errors, because wind can (remix ash and a particle produced in one area can be easily exported to other.

  11. Successful operation of continuous reactors at short retention times results in high-density, fast-rate Dehalococcoides dechlorinating cultures.

    Science.gov (United States)

    Delgado, Anca G; Fajardo-Williams, Devyn; Popat, Sudeep C; Torres, César I; Krajmalnik-Brown, Rosa

    2014-03-01

    The discovery of Dehalococcoides mccartyi reducing perchloroethene and trichloroethene (TCE) to ethene was a key landmark for bioremediation applications at contaminated sites. D. mccartyi-containing cultures are typically grown in batch-fed reactors. On the other hand, continuous cultivation of these microorganisms has been described only at long hydraulic retention times (HRTs). We report the cultivation of a representative D. mccartyi-containing culture in continuous stirred-tank reactors (CSTRs) at a short, 3-d HRT, using TCE as the electron acceptor. We successfully operated 3-d HRT CSTRs for up to 120 days and observed sustained dechlorination of TCE at influent concentrations of 1 and 2 mM TCE to ≥ 97 % ethene, coupled to the production of 10(12) D. mccartyi cells Lculture (-1). These outcomes were possible in part by using a medium with low bicarbonate concentrations (5 mM) to minimize the excessive proliferation of microorganisms that use bicarbonate as an electron acceptor and compete with D. mccartyi for H2. The maximum conversion rates for the CSTR-produced culture were 0.13 ± 0.016, 0.06 ± 0.018, and 0.02 ± 0.007 mmol Cl(-) Lculture (-1) h(-1), respectively, for TCE, cis-dichloroethene, and vinyl chloride. The CSTR operation described here provides the fastest laboratory cultivation rate of high-cell density Dehalococcoides cultures reported in the literature to date. This cultivation method provides a fundamental scientific platform for potential future operations of such a system at larger scales.

  12. A novel peak detection approach with chemical noise removal using short-time FFT for prOTOF MS data.

    Science.gov (United States)

    Zhang, Shuqin; Wang, Honghui; Zhou, Xiaobo; Hoehn, Gerard T; DeGraba, Thomas J; Gonzales, Denise A; Suffredini, Anthony F; Ching, Wai-Ki; Ng, Michael K; Wong, Stephen T C

    2009-08-01

    Peak detection is a pivotal first step in biomarker discovery from MS data and can significantly influence the results of downstream data analysis steps. We developed a novel automatic peak detection method for prOTOF MS data, which does not require a priori knowledge of protein masses. Random noise is removed by an undecimated wavelet transform and chemical noise is attenuated by an adaptive short-time discrete Fourier transform. Isotopic peaks corresponding to a single protein are combined by extracting an envelope over them. Depending on the S/N, the desired peaks in each individual spectrum are detected and those with the highest intensity among their peak clusters are recorded. The common peaks among all the spectra are identified by choosing an appropriate cut-off threshold in the complete linkage hierarchical clustering. To remove the 1 Da shifting of the peaks, the peak corresponding to the same protein is determined as the detected peak with the largest number among its neighborhood. We validated this method using a data set of serial peptide and protein calibration standards. Compared with MoverZ program, our new method detects more peaks and significantly enhances S/N of the peak after the chemical noise removal. We then successfully applied this method to a data set from prOTOF MS spectra of albumin and albumin-bound proteins from serum samples of 59 patients with carotid artery disease compared to vascular disease-free patients to detect peaks with S/N> or =2. Our method is easily implemented and is highly effective to define peaks that will be used for disease classification or to highlight potential biomarkers.

  13. What do short-term and long-term relationships look like? Building the relationship coordination and strategic timing (ReCAST) model.

    Science.gov (United States)

    Eastwick, Paul W; Keneski, Elizabeth; Morgan, Taylor A; McDonald, Meagan A; Huang, Sabrina A

    2018-05-01

    Close relationships research has examined committed couples (e.g., dating relationships, marriages) using intensive methods that plot relationship development over time. But a substantial proportion of people's real-life sexual experiences take place (a) before committed relationships become "official" and (b) in short-term relationships; methods that document the time course of relationships have rarely been applied to these contexts. We adapted a classic relationship trajectory-plotting technique to generate the first empirical comparisons between the features of people's real-life short-term and long-term relationships across their entire timespan. Five studies compared long-term and short-term relationships in terms of the timing of relationship milestones (e.g., flirting, first sexual intercourse) and the occurrence/intensity of important relationship experiences (e.g., romantic interest, strong sexual desire, attachment). As romantic interest was rising and partners were becoming acquainted, long-term and short-term relationships were indistinguishable. Eventually, romantic interest in short-term relationships plateaued and declined while romantic interest in long-term relationships continued to rise, ultimately reaching a higher peak. As relationships progressed, participants evidenced more features characteristic of the attachment-behavioral system (e.g., attachment, caregiving) in long-term than short-term relationships but similar levels of other features (e.g., sexual desire, self-promotion, intrasexual competition). These data inform a new synthesis of close relationships and evolutionary psychological perspectives called the Relationship Coordination and Strategic Timing (ReCAST) model. ReCAST depicts short-term and long-term relationships as partially overlapping trajectories (rather than relationships initiated with distinct strategies) that differ in their progression along a normative relationship development sequence. (PsycINFO Database Record (c

  14. Large volume recycling of oceanic lithosphere over short time scales: geochemical constraints from the Caribbean Large Igneous Province

    Science.gov (United States)

    Hauff, F.; Hoernle, K.; Tilton, G.; Graham, D. W.; Kerr, A. C.

    2000-01-01

    Oceanic flood basalts are poorly understood, short-term expressions of highly increased heat flux and mass flow within the convecting mantle. The uniqueness of the Caribbean Large Igneous Province (CLIP, 92-74 Ma) with respect to other Cretaceous oceanic plateaus is its extensive sub-aerial exposures, providing an excellent basis to investigate the temporal and compositional relationships within a starting plume head. We present major element, trace element and initial Sr-Nd-Pb isotope composition of 40 extrusive rocks from the Caribbean Plateau, including onland sections in Costa Rica, Colombia and Curaçao as well as DSDP Sites in the Central Caribbean. Even though the lavas were erupted over an area of ˜3×10 6 km 2, the majority have strikingly uniform incompatible element patterns (La/Yb=0.96±0.16, n=64 out of 79 samples, 2σ) and initial Nd-Pb isotopic compositions (e.g. 143Nd/ 144Nd in=0.51291±3, ɛNdi=7.3±0.6, 206Pb/ 204Pb in=18.86±0.12, n=54 out of 66, 2σ). Lavas with endmember compositions have only been sampled at the DSDP Sites, Gorgona Island (Colombia) and the 65-60 Ma accreted Quepos and Osa igneous complexes (Costa Rica) of the subsequent hotspot track. Despite the relatively uniform composition of most lavas, linear correlations exist between isotope ratios and between isotope and highly incompatible trace element ratios. The Sr-Nd-Pb isotope and trace element signatures of the chemically enriched lavas are compatible with derivation from recycled oceanic crust, while the depleted lavas are derived from a highly residual source. This source could represent either oceanic lithospheric mantle left after ocean crust formation or gabbros with interlayered ultramafic cumulates of the lower oceanic crust. High 3He/ 4He in olivines of enriched picrites at Quepos are ˜12 times higher than the atmospheric ratio suggesting that the enriched component may have once resided in the lower mantle. Evaluation of the Sm-Nd and U-Pb isotope systematics on

  15. A voxel-based investigation for MRI-only radiotherapy of the brain using ultra short echo times

    Science.gov (United States)

    Edmund, Jens M.; Kjer, Hans M.; Van Leemput, Koen; Hansen, Rasmus H.; Andersen, Jon AL; Andreasen, Daniel

    2014-12-01

    Radiotherapy (RT) based on magnetic resonance imaging (MRI) as the only modality, so-called MRI-only RT, would remove the systematic registration error between MR and computed tomography (CT), and provide co-registered MRI for assessment of treatment response and adaptive RT. Electron densities, however, need to be assigned to the MRI images for dose calculation and patient setup based on digitally reconstructed radiographs (DRRs). Here, we investigate the geometric and dosimetric performance for a number of popular voxel-based methods to generate a so-called pseudo CT (pCT). Five patients receiving cranial irradiation, each containing a co-registered MRI and CT scan, were included. An ultra short echo time MRI sequence for bone visualization was used. Six methods were investigated for three popular types of voxel-based approaches; (1) threshold-based segmentation, (2) Bayesian segmentation and (3) statistical regression. Each approach contained two methods. Approach 1 used bulk density assignment of MRI voxels into air, soft tissue and bone based on logical masks and the transverse relaxation time T2 of the bone. Approach 2 used similar bulk density assignments with Bayesian statistics including or excluding additional spatial information. Approach 3 used a statistical regression correlating MRI voxels with their corresponding CT voxels. A similar photon and proton treatment plan was generated for a target positioned between the nasal cavity and the brainstem for all patients. The CT agreement with the pCT of each method was quantified and compared with the other methods geometrically and dosimetrically using both a number of reported metrics and introducing some novel metrics. The best geometrical agreement with CT was obtained with the statistical regression methods which performed significantly better than the threshold and Bayesian segmentation methods (excluding spatial information). All methods agreed significantly better with CT than a reference water MRI

  16. Flavor and flavor chemistry differences among milks processed by high-temperature, short-time pasteurization or ultra-pasteurization.

    Science.gov (United States)

    Jo, Y; Benoist, D M; Barbano, D M; Drake, M A

    2018-05-01

    Typical high-temperature, short-time (HTST) pasteurization encompasses a lower heat treatment and shorter refrigerated shelf life compared with ultra-pasteurization (UP) achieved by direct steam injection (DSI-UP) or indirect heat (IND-UP). A greater understanding of the effect of different heat treatments on flavor and flavor chemistry of milk is required to characterize, understand, and identify the sources of flavors. The objective of this study was to determine the differences in the flavor and volatile compound profiles of milk subjected to HTST, DSI-UP, or IND-UP using sensory and instrumental techniques. Raw skim and raw standardized 2% fat milks (50 L each) were processed in triplicate and pasteurized at 78°C for 15 s (HTST) or 140°C for 2.3 s by DSI-UP or IND-UP. Milks were cooled and stored at 4°C, then analyzed at d 0, 3, 7, and 14. Sensory attributes were determined using a trained panel, and aroma active compounds were evaluated by solid-phase micro-extraction or stir bar sorptive extraction followed by gas chromatography-mass spectrometry, gas chromatography-olfactometry, and gas chromatography-triple quad mass spectrometry. The UP milks had distinct cooked and sulfur flavors compared with HTST milks. The HTST milks had less diversity in aroma active compounds compared with UP milks. Flavor intensity of all milks decreased by d 14 of storage. Aroma active compound profiles were affected by heat treatment and storage time in both skim and 2% milk. High-impact aroma active compounds were hydrogen sulfide, dimethyl trisulfide, and methional in DSI-UP and 2 and 3-methylbutanal, furfural, 2-heptanone, 2-acetyl-1-pyrroline, 2-aminoacetophenone, benzaldehyde, and dimethyl sulfide in IND-UP. These results provide a foundation knowledge of the effect of heat treatments on flavor development and differences in sensory quality of UP milks. Copyright © 2018 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  17. Automatic moment segmentation and peak detection analysis of heart sound pattern via short-time modified Hilbert transform.

    Science.gov (United States)

    Sun, Shuping; Jiang, Zhongwei; Wang, Haibin; Fang, Yu

    2014-05-01

    This paper proposes a novel automatic method for the moment segmentation and peak detection analysis of heart sound (HS) pattern, with special attention to the characteristics of the envelopes of HS and considering the properties of the Hilbert transform (HT). The moment segmentation and peak location are accomplished in two steps. First, by applying the Viola integral waveform method in the time domain, the envelope (E(T)) of the HS signal is obtained with an emphasis on the first heart sound (S1) and the second heart sound (S2). Then, based on the characteristics of the E(T) and the properties of the HT of the convex and concave functions, a novel method, the short-time modified Hilbert transform (STMHT), is proposed to automatically locate the moment segmentation and peak points for the HS by the zero crossing points of the STMHT. A fast algorithm for calculating the STMHT of E(T) can be expressed by multiplying the E(T) by an equivalent window (W(E)). According to the range of heart beats and based on the numerical experiments and the important parameters of the STMHT, a moving window width of N=1s is validated for locating the moment segmentation and peak points for HS. The proposed moment segmentation and peak location procedure method is validated by sounds from Michigan HS database and sounds from clinical heart diseases, such as a ventricular septal defect (VSD), an aortic septal defect (ASD), Tetralogy of Fallot (TOF), rheumatic heart disease (RHD), and so on. As a result, for the sounds where S2 can be separated from S1, the average accuracies achieved for the peak of S1 (AP₁), the peak of S2 (AP₂), the moment segmentation points from S1 to S2 (AT₁₂) and the cardiac cycle (ACC) are 98.53%, 98.31% and 98.36% and 97.37%, respectively. For the sounds where S1 cannot be separated from S2, the average accuracies achieved for the peak of S1 and S2 (AP₁₂) and the cardiac cycle ACC are 100% and 96.69%. Copyright © 2014 Elsevier Ireland Ltd. All

  18. Dynamics of Al/Fe{sub 2}O{sub 3} MIC combustion from short single-pulse photothermal initiation and time-resolved spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Stiegman, Albert E.; Park, Chi-Dong; Mileham, Melissa; Van de Burgt, Lambertus J. [Department of Chemistry and Biochemistry, Florida State University Tallahassee, FL (United States); Kramer, Michael P. [AFRL/MNME Eglin AFB, FL (United States)

    2009-08-15

    Time-resolved spectroscopy was used to study the dynamics of the photothermal ignition of Al/Fe{sub 2}O{sub 3} metastable intermolecular composites after single short-pulse laser initiation. The dynamics were recorded in several time domains from nanosecond to microsecond to quantify the dynamics from initial laser excitation to combustion. Time-averaged spectral data were also collected for the overall emission occurring during combustion. (Abstract Copyright [2009], Wiley Periodicals, Inc.)

  19. Neutron activation analysis of trace metallic elements eluted from molecular sieves in the dehydration process of safflower oil

    Energy Technology Data Exchange (ETDEWEB)

    Takasago, Masahisa; Kobayashi, Koichi; Taru, Yasunori; Takaoka, Kyo (Musashi Inst. of Tech., Tokyo (Japan))

    1992-11-01

    Dissolved water in safflower oil affects the autoxidation of this oil significantly. Molecular sieves were used to remove the dissolved water from the oil. This method is much simpler than that of distillation, and dissolved water can be removed to the same extent as that by distillation. But, due to the elution of many kinds of trace metallic elements in the oil dehydrated with molecular sieves, these elements were analyzed by neutron activation analysis. For a data comparison trace amounts of metallic elements in the oil dehydrated by distillation were also analyzed. Since the intensity of the [gamma] ray-photoelectric peak of nuclide [sup 28]Al was largest among the detected elements, this element was analyzed quantitatively and the other elements qualitatively. In safflower oil dehydrated with molecular sieves, 14 kinds of the elements (I, Br, Al, Mg, Si, V, Cl, Nd, Ta, Cr, Sb, Cs, Co, Na) were detected. Also, I, Br, Cl, Cr, Ta, Sb, and Al elements were detected in the oil dehydrated by distillation. The intensity of the photoelectric peak of nuclide except [sup 28]Al was essentially the same as that in the oil dehydrated by distillation, but the intensity of [sup 28]Al in the oil with molecular sieves was about 28 times stronger than that in distillation oil. In the molecular sieves, 19 impure elements in addition to the original constituents (Na, K, Al, si, O) were detected. It was Al, Na, Si, Nd, Cs, and Co along with impure elements may possibly have been eluted in the oil. Al element in safflower oil dehydrated with molecular sieves was analyzed quantitatively. 0.91 ppm of Al was detected in safflower oil. The eluted amount of Al in safflower oil dehydrated by distillation was 0.032 ppm. A larger amount of Al element was thus eluted into the oil dehydrated with molecular sieves than by distillation. (author).

  20. Neutron activation analysis of trace metallic elements eluted from molecular sieves in the dehydration process of safflower oil

    International Nuclear Information System (INIS)

    Takasago, Masahisa; Kobayashi, Koichi; Taru, Yasunori; Takaoka, Kyo

    1992-01-01

    Dissolved water in safflower oil affects the autoxidation of this oil significantly. Molecular sieves were used to remove the dissolved water from the oil. This method is much simpler than that of distillation, and dissolved water can be removed to the same extent as that by distillation. But, due to the elution of many kinds of trace metallic elements in the oil dehydrated with molecular sieves, these elements were analyzed by neutron activation analysis. For a data comparison trace amounts of metallic elements in the oil dehydrated by distillation were also analyzed. Since the intensity of the γ ray-photoelectric peak of nuclide 28 Al was largest among the detected elements, this element was analyzed quantitatively and the other elements qualitatively. In safflower oil dehydrated with molecular sieves, 14 kinds of the elements (I, Br, Al, Mg, Si, V, Cl, Nd, Ta, Cr, Sb, Cs, Co, Na) were detected. Also, I, Br, Cl, Cr, Ta, Sb, and Al elements were detected in the oil dehydrated by distillation. The intensity of the photoelectric peak of nuclide except 28 Al was essentially the same as that in the oil dehydrated by distillation, but the intensity of 28 Al in the oil with molecular sieves was about 28 times stronger than that in distillation oil. In the molecular sieves, 19 impure elements in addition to the original constituents (Na, K, Al, si, O) were detected. It was Al, Na, Si, Nd, Cs, and Co along with impure elements may possibly have been eluted in the oil. Al element in safflower oil dehydrated with molecular sieves was analyzed quantitatively. 0.91 ppm of Al was detected in safflower oil. The eluted amount of Al in safflower oil dehydrated by distillation was 0.032 ppm. A larger amount of Al element was thus eluted into the oil dehydrated with molecular sieves than by distillation. (author)

  1. Elution-extrusion counter-current chromatography for the separation of two pairs of isomeric monoterpenes from Paeoniae Alba Radix.

    Science.gov (United States)

    Chu, Chu; Zhang, Shidi; Tong, Shengqiang; Li, Xingnuo; Li, Qingyong; Yan, Jizhong

    2015-09-01

    In this work, a simple and efficient protocol for the rapid separation of two pairs of isomeric monoterpenes from Paeoniae Alba Radix was developed by combining macroporous resin and elution-extrusion counter-current chromatography. The crude extract was firstly subjected to a D101 macroporous resin column eluted with water and a series of different concentrations of ethanol. Then, effluents of 30 and 95% ethanol were collected as sample 1 and sample 2 for further counter-current chromatography purification. Finally, a pair of isomers, 96 mg of compound 1 and 48 mg of compound 2 with purities of 91.1 and 96.2%, respectively, was isolated from 200 mg of sample 1. The other pair of isomers, 14 mg of compound 3 and 8 mg of compound 4 with purities of 93.6 and 88.9%, respectively, was isolated from 48 mg of sample 2. Their purities were analyzed by high-performance liquid chromatography, and their chemical structures were identified by mass spectrometry and (1) H NMR spectroscopy. Compared to a normal counter-current chromatography separation, the separation time and solvent consumption of elution-extrusion counter-current chromatography were reduced while the resolutions were still good. The established protocol is promising for the separation of natural products with great disparity of content in herbal medicines. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Study of the elution {sup 99}Mo-{sup 99m}Tc generators produced at IPEN-CNEN/SP

    Energy Technology Data Exchange (ETDEWEB)

    Lopes, Paula Regina Corain [Pontificia Univ. Catolica de Sao Paulo, SP (Brazil); Instituto de Pesquisas Energeticas e Nucleares IPEN/CNEN-SP, Sao Paulo, SP (Brazil)]. E-mail: corain.lopes@uol.com.br; Osso Junior, Joao Alberto [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)]. E-mail: jaosso@ipen.br

    2007-07-01

    Over the last years {sup 99m}Tc has become a very important asset in modern nuclear medicine, due to the emission of gamma ray of optimal energy (140 keV) and a suitable half-life (6.04 h). A further attribute of {sup 99m}Tc is its formation from the decay of {sup 99}Mo and the availability from {sup 99}Mo-{sup 99m}Tc generator systems. The most common and practical generator types consist of a chromatographic column packed with aluminium oxide, onto which the highly purified fission product {sup 99}Mo (imported from Canada) is adsorbed in the form of molybdate. {sup 99m}Tc is further eluted with saline solution. The objective of this work is to study the performance and the elution profile of {sup 99m}Tc from high activity generators in order to decrease molybdenum and aluminium concentration. The experiments involved the use of paper filters and Sep Pak columns and also the changing in the time interval between elutions. {sup 99}Mo breakthrough was measured using a dose calibrator and aluminium by UV-Vis spectrophotometry. The best results were achieved using a Sep Pak column containing neutral aluminium oxide. (author)

  3. Study of the elution 99Mo-99mTc generators produced at IPEN-CNEN/SP

    International Nuclear Information System (INIS)

    Lopes, Paula Regina Corain; Osso Junior, Joao Alberto

    2007-01-01

    Over the last years 99m Tc has become a very important asset in modern nuclear medicine, due to the emission of gamma ray of optimal energy (140 keV) and a suitable half-life (6.04 h). A further attribute of 99m Tc is its formation from the decay of 99 Mo and the availability from 99 Mo- 99m Tc generator systems. The most common and practical generator types consist of a chromatographic column packed with aluminium oxide, onto which the highly purified fission product 99 Mo (imported from Canada) is adsorbed in the form of molybdate. 99m Tc is further eluted with saline solution. The objective of this work is to study the performance and the elution profile of 99m Tc from high activity generators in order to decrease molybdenum and aluminium concentration. The experiments involved the use of paper filters and Sep Pak columns and also the changing in the time interval between elutions. 99 Mo breakthrough was measured using a dose calibrator and aluminium by UV-Vis spectrophotometry. The best results were achieved using a Sep Pak column containing neutral aluminium oxide. (author)

  4. Leisure-time physical activity and direct cost of short-term sickness absence among Finnish municipal employees.

    Science.gov (United States)

    Tolonen, Anu; Rahkonen, Ossi; Lahti, Jouni

    2017-03-04

    We aimed to examine the direct costs of short-term (1-14 days) sickness absence and the effect of employees' physical activity on the costs. The Finnish Helsinki Health Study survey (2007) was used in the analysis (n = 3,935). Physical activity was classified into inactive, moderately active, and vigorously active. Sickness absence (3 years follow-up) and salary data were derived from the employer's registers. On average, an employee was absent 6 days a year due to short-term sickness absence, with a production loss of 2,350 EUR during the 3 years. The vigorously active had less sickness absence than those less active. The direct cost of sickness absence of a vigorously active employee was 404 EUR less than that of an inactive employee. Promoting physical activity among employees may decrease direct cost of short-term sickness absence.

  5. Determinants of protein elution rates from preparative ion-exchange adsorbents.

    Science.gov (United States)

    Angelo, James M; Lenhoff, Abraham M

    2016-04-01

    The rate processes involved in elution in preparative chromatography can affect both peak resolution and hence selectivity as well as practical factors such as facility fit. These processes depend on the physical structure of the adsorbent particles, the amount of bound solute, the solution conditions for operation or some combination of these factors. Ion-exchange adsorbents modified with covalently attached or grafted polymer layers have become widely used in preparative chromatography. Their often easily accessible microstructures offer substantial binding capacities for biomolecules, but elution has sometimes been observed to be undesirably slow. In order to determine which physicochemical phenomena control elution behavior, commercially available cellulosic, dextran-grafted and unmodified agarose materials were characterized here by their elution profiles at various conditions, including different degrees of loading. Elution data were analyzed under the assumption of purely diffusion-limited control, including the role of pore structure properties such as porosity and tortuosity. In general, effective elution rates decreased with the reduction of accessible pore volume, but differences among different proteins indicated the roles of additional factors. Additional measurements and analysis, including the use of confocal laser scanning microscopy to observe elution within single chromatographic particles, indicated the importance of protein association within the particle during elution. The use of protein stabilizing agents was explored in systems presenting atypical elution behavior, and l-arginine and disaccharide excipients were shown to alleviate the effects for one protein, lysozyme, in the presence of sodium chloride. Incorporation of these excipients into eluent buffer gave rise to faster elution and significantly lower pool volumes in elution from polymer-modified adsorbents. Copyright © 2016 Elsevier B.V. All rights reserved.

  6. 2-year clinical outcomes after implantation of sirolimus-eluting, paclitaxel-eluting, and bare-metal coronary stents: results from the WDHR (Western Denmark Heart Registry)

    DEFF Research Database (Denmark)

    Kaltoft, Anne; Jensen, Lisette Okkels; Maeng, Michael

    2009-01-01

    OBJECTIVES: This registry study assessed the safety and efficacy of the 2 types of drug-eluting stents (DES), sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES), compared with bare-metal stents (BMS). BACKGROUND: Drug-eluting stents may increase the risk of stent thrombosis (ST...... databases. We used Cox regression analysis to control for confounding. RESULTS: The 2-year incidence of definite ST was 0.64% in BMS patients, 0.79% in DES patients (adjusted relative risk [RR]: 1.09; 95% confidence interval [CI]: 0.72 to 1.65), 0.50% in SES patients (adjusted RR: 0.63, 95% CI: 0.35 to 1...

  7. Development of DNA elution method to detect irradiated foodstuff

    International Nuclear Information System (INIS)

    Copin, M.P.; Bourgeois, C.M.

    1991-01-01

    The aim of the work is to develop a reliable method to detect whether a fresh and frozen foodstuff has been irradiated. The molecule of DNA is one of the targets of ionizing radiation. The induction of three major classes of lesion have been shown. Double strand breaks, single strand breaks and base damage. Among the different techniques used to observe and quantify the strand breaks, techniques of elution are very interesting. The method proposed consisted of a filtration of the DNA at the atmospheric pressure and in non denaturing conditions. The amount of DNA retained on the filter is measured after being suitably labelled by microfluorometry. A difference in the amount of DNA retained on a filter of 2 μm from a lysed muscular tissue sample between a frozen Norway lobster which has been irradiated and one which has not, is observed. 7 refs

  8. Alkaline elution of uranium and molybdenum and their recovery

    International Nuclear Information System (INIS)

    Song Wenlan; Wu Peisheng; Zhao Pinzhi; Tao Dening; Xie Chaoyan

    1987-01-01

    The uranium and molybdenum can be simultaneously eluted by using eluant (NH 4 ) 2 CO 3 + (NH 4 ) 2 SO 4 from resin loaded uranium and molybdenum. The ADU is precipitated from eluant by volatilization of ammonia. The molybdenum is extracted by TFA-TBP-kerosene from the filtrate at pH 3.0-3.2 with molybdenum extraction > 98%. Uranium is nearly not extracted. The precipitation of Mo is reached by sulphuric acid after stripping and the ammonium multimolybdate is obtained. This process can give the total recovery more than 99% for U and 90% for Mo. Because of the use of sulphate salt system, the hazard of NO 3 - can be avoided

  9. Quantitation of radiolabeled compounds eluting from the HPLC system

    International Nuclear Information System (INIS)

    Kessler, M.J.

    1982-01-01

    Three techniques are compared for the quantitation of various radiolabeled compounds eluting in the high performance liquid chromatography system. The first technique requires fraction-collecting the effluent from the HPLC, removing an aliquot to scintillation vials, and counting each fraction in a liquid scintillation counter. The second uses direct interface of the HPLC effluent to a flow-through radioactivity detector. The third involves quantitation of various radiolabeled compounds (proteins, steroids, and nucleotides) by splitting the effluent from the HPLC with an electronic steam splitter, thus diverting a present portion to the fraction collector for further chemical characterization and the remainder to the radioactivity flow detector for direct quantitation. A direct comparison of the chromatograms and the radioactivity counting efficiencies of these three techniques is presented

  10. Drug-eluting stents to prevent stent thrombosis and restenosis.

    Science.gov (United States)

    Im, Eui; Hong, Myeong-Ki

    2016-01-01

    Although first-generation drug-eluting stents (DES) have significantly reduced the risk of in-stent restenosis, they have also increased the long-term risk of stent thrombosis. This safety concern directly triggered the development of new generation DES, with innovations in stent platforms, polymers, and anti-proliferative drugs. Stent platform materials have evolved from stainless steel to cobalt or platinum-chromium alloys with an improved strut design. Drug-carrying polymers have become biocompatible or biodegradable and even polymer-free DES were introduced. New limus-family drugs (such as everolimus, zotarolimus or biolimus) were adopted to enhance stent performances. As a result, these new DES demonstrated superior vascular healing responses on intracoronary imaging studies and lower stent thrombotic events in actual patients. Recently, fully-bioresorbable stents (scaffolds) have been introduced, and expanding their applications. In this article, the important concepts and clinical results of new generation DES and bioresorbable scaffolds are described.

  11. 2-Hydroxyglutarate Detection by Short Echo Time Magnetic Resonance Spectroscopy in Routine Imaging Study of Brain Glioma at 3.0 T.

    Science.gov (United States)

    Crisi, Girolamo; Filice, Silvano; Michiara, Maria; Crafa, Pellegrino; Lana, Silvia

    The objective of this study was to assess the effective performance of short echo time magnetic resonance spectroscopy (short TE MRS) for 2HG detection as biomarker of isocitrate dehydrogenase (IDH) status in all grade glioma (GL). A total of 82 GL patients were prospectively investigated by short TE MRS at 3.0 T as part of a multimodal magnetic resonance imaging study protocol. Spectral analysis was performed using linear combination model. Tumor specimens were diagnosed as IDH mutant or wild type according to the 2016 World Health Organization (WHO) classification of brain tumors. Spectra were analyzed for the presence of 2HG. The performance of short TE MRS was evaluated in terms of sensitivity, specificity, and positive and negative likelihood ratio on the overall sample and on GL WHO grades II and III and glioblastoma separately. The specificity and sensitivity estimated on the overall sample were 88% and 77%, respectively. In GL WHO grades II and III, 100% specificity and 75% sensitivity were estimated. We reiterate the feasibility to identify IDH status of brain GL using short TE MRS at 3.0 T. The method can correctly detect 2HG as expression of IDH mutation in WHO grades II and III GL with a 100% specificity but a 75% sensitivity. In the evaluation of glioblastoma, short TE MRS performs poorly having a 17% false positive rate.

  12. Short-term variations of Icelandic ice cap mass inferred from cGPS coordinate time series

    DEFF Research Database (Denmark)

    Compton, Kathleen; Bennett, Richard A.; Hreinsdóttir, Sigrún

    2017-01-01

    As the global climate changes, understanding short-term variations in water storage is increasingly important. Continuously operating Global Positioning System (cGPS) stations in Iceland record annual periodic motion—the elastic response to winter accumulation and spring melt seasons—with peak-to...

  13. Changes in Children's Perception-Action Tuning over Short Time Scales: Bicycling across Traffic-Filled Intersections in a Virtual Environment

    Science.gov (United States)

    Plumert, Jodie M.; Kearney, Joseph K.; Cremer, James F.; Recker, Kara M.; Strutt, Jonathan

    2011-01-01

    This investigation examined short-term changes in child and adult cyclists' gap decisions and movement timing in response to general and specific road-crossing experiences. Children (10- and 12-year-olds) and adults rode a bicycle through a virtual environment with 12 intersections. Participants faced continuous cross traffic and waited for gaps…

  14. Cost and time models for the evaluation of intermodal chains by using short sea shipping in the North Sea Region: the Rosyth-Zeebrugge route

    DEFF Research Database (Denmark)

    Lopez, Alba Martínez; Kronbak, Jacob; Jiang, Liping

    2015-01-01

    This paper is framed in the context of the EU Interreg IVB North Sea Region project Food Port. In line with this project, this paper aims to define mathematically cost and time models able to provide realistic information about the performances of road haulage and of intermodal chains using short...

  15. The effect of chorionicity and twin-to-twin delivery time interval on short-term outcome of the second twin

    DEFF Research Database (Denmark)

    Hjortø, Sofie; Nickelsen, Carsten; Petersen, Janne

    2013-01-01

    Abstract Objectives: To investigate the effect of chorionicity and twin-to-twin delivery time interval on short-term outcome in the second twin. Additionally, to investigate predictors of adverse outcome in both twins. Methods: Data included vaginally delivered twins (≥ 36 weeks) from Copenhagen ...

  16. Inventory Modelling for a Manufacturer of Sweets : An Evaluation of an Adjusted Compund Renewal Approach for B-Items With A Relative Short Production Lead Time

    NARCIS (Netherlands)

    Heuts, R.M.J.; Luijten, M.L.J.

    1999-01-01

    In this paper we are especially interested how to optimize the production/inventory control for a manufacturer of sweets, under the following circumstances: short production lead times in combination with an intermittent demand pattern for the so-called B-taste items. As for A-taste items a compound

  17. Drug-eluting stents studies in mice: Do we need atherosclerosis to study restenosis?

    NARCIS (Netherlands)

    Pires, N.M.M.; Jukema, J.W.; Daemen, M.J.A.P.; Quax, P.H.A.

    2006-01-01

    In 2001, the first human study with drug-eluting stents (DES) was published showing a nearly complete abolition of restenosis by using a sirolimus-eluting stent. This success was very encouraging to test new compounds in combination with the DES platform. Nevertheless, several other anti-restenotic

  18. Possibility of obtaining enriched americium-242g by the elution of recoil atoms from zeolite

    Energy Technology Data Exchange (ETDEWEB)

    Shafiev, A I; Vityutnev, V M; Ivanov, V M; Yakovlev, G N

    1974-12-31

    On the example of production the possibility of obtaining enriched actinide isotopes by the elution of recotl atoms with the use of a zeolite- americium-241 target was shown. The enrichment factor and the recoil atoms of / sup 242g/Am yield depend on preliminary target treatment and solution composition used for elution. (auth)

  19. Elution behavior of heavy metals from cement solidified products of incinerated ash waste - 59102

    International Nuclear Information System (INIS)

    Meguro, Yoshihiro; Kawato, Yoshimi; Nakayama, Takuya; Tomioka, Osamu; Mitsuda, Motoyuki

    2012-01-01

    A method, in which incinerated ash is solidified with a cement material, has been developed to dispose radioactive incinerated ash waste. In order to bury the solidified product, it is required that elution of hazardous heavy metals included in the ash from the solidified products is inhibited. In this study, the elution behavior of the heavy metals from the synthetic solidified products, which included Pb(II), Cd(II), and Cr(VI) and were prepared using ordinary portland cement (OPC), blast furnace slag cement (BFS), or a cement material that showed low alkalinity (LA-Cement), was investigated. Several chemicals and materials were added as additive agents to prevent the elution of the heavy metals. When OPC was used, Cd elution was inhibited, but Pb and Cr were not enough even using the additive agent examined. FeSO 4 and Na 2 S additive agents worked effective to inhibit elution of Cr. When BFS was used, the elution of Pb, Cd and Cr was inhibited for the all products prepared. In the case of LA-Cement, the elution of Pb and Cd was inhibited for the all products, but only the product that was added FeSO 4 showed good result of the elution of Cr. (authors)

  20. Cefoperazone and cefoperazone-sulbactam susceptibility tests with anaerobic bacteria by the thioglycolate disk elution method.

    OpenAIRE

    Barry, A L; Packer, R R; Jones, R N

    1985-01-01

    Tests were performed with 104 anaerobic microorganisms to evaluate the thioglycolate disk elution technique for the detection of resistance to cefoperazone and cefoperazone-sulbactam. An unacceptably high false-resistance rate and a poor reproducibility record make the disk elution procedure unsatisfactory for routine testing of this drug or combination of drugs.