WorldWideScience

Sample records for shih-chang hu paul

  1. Paul Dirac

    Science.gov (United States)

    Pais, Abraham; Jacob, Maurice; Olive, David I.; Atiyah, Michael F.

    2005-09-01

    Preface Peter Goddard; Dirac memorial address Stephen Hawking; 1. Paul Dirac: aspects of his life and work Abraham Pais; 2. Antimatter Maurice Jacob; 3. The monopole David Olive; 4. The Dirac equation and geometry Michael F. Atiyah.

  2. Paul Ehrenfest

    International Nuclear Information System (INIS)

    Broda, E.

    1982-01-01

    This is a short biography about Paul Ehrenfest, a famous austrian physicist and student of Ludwig Boltzmann. Ehrenfest contributed important work to thermodynamics and quantum mechanics (a.o. adiabatic invariants, and the Ehrenfest theorem). Broda describes not only his scientific research but also his interaction and relation to other famous physicist of his time, like Erwin Schrödinger, Albert Einstein and others. (nowak)

  3. Paul Schwabe | NREL

    Science.gov (United States)

    . Cory, and J. Newcomb. 2009. Renewable Energy Project Financing: Impacts of the Financial Crisis and Schwabe Photo of Paul Schwabe Paul Schwabe Project Manager IV-Research Paul.Schwabe@nrel.gov | 303 . Cory, K. and P. Schwabe. 2009. Wind Levelized Cost of Energy: A Comparison of Technical and Financing

  4. Paul Rodgersi filter Kohilas

    Index Scriptorium Estoniae

    2000-01-01

    28. I Kohila keskkoolis kohaspetsiifiline skulptuur ja performance "Filter". Kooli 130. aastapäeva tähistava ettevõtmise eesotsas oli skulptor Paul Rodgers ja kaks viimase klassi noormeest ئ Marko Heinmäe, Hendrik Karm.

  5. Illusoorne autentsus / Toomas Paul

    Index Scriptorium Estoniae

    Paul, Toomas, 1939-

    2000-01-01

    Arvustus: Taylor, Charles. Autentsuse eetika / inglise k. tlk. Märt Väljataga. Tallinn : Hortus Litterarum, 2000. (Avatud Eesti raamat). Ilmunud ka kogumikus: Paul, Toomas. Kirik keset küla. Tartu : Ilmamaa, 2003, lk. 311-317

  6. Paul Callaghan luminous moments

    CERN Document Server

    Callaghan, Paul

    2013-01-01

    Acknowledged internationally for his ground-breaking scientific research in the field of magnetic resonance, Sir Paul Callaghan was a scientist and visionary with a rare gift for promoting science to a wide audience. He was named New Zealander of the Year in 2011. His death in early 2012 robbed New Zealand of an inspirational leader. Paul Callaghan: Luminous Moments brings together some of his most significant writing. Whether he describes his childhood in Wanganui, reflects on discovering the beauty of science, sets out New Zealand's future potential or discusses the experience of fa

  7. Paul S Follansbee

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Paul S Follansbee. Articles written in Resonance – Journal of Science Education. Volume 11 Issue 6 June 2006 pp 8-25 General Article. Dr Smith goes to Los Alamos - Cyril Stanley Smith, Plutonium Metallurgy, and the Manhattan Project · Srivilliputhur G ...

  8. Pauling, Prof. Linus Carl

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1949 Honorary. Pauling, Prof. Linus Carl Nobel Laureate (Chemistry) - 1954; Peace - 1962. Date of birth: 28 February 1901. Date of death: 19 August 1994. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th ...

  9. Paul and Africa?

    African Journals Online (AJOL)

    Test

    2011-06-07

    Jun 7, 2011 ... The relationship between Saint Paul and the continent of Africa has never been a significant point of ... It consists of a constructive dialogue between a biblical original culture, .... John Walter Gregory to a continuous geological crack. (valley) of ...... As Stanley E. Porter concludes in his study on 2 Corinthians.

  10. HuMax-CD4

    DEFF Research Database (Denmark)

    Skov, Lone; Kragballe, Knud; Zachariae, Claus

    2003-01-01

    BACKGROUND: Psoriasis is characterized by infiltration with mononuclear cells. Especially activated memory CD4+ T cells are critical in the pathogenesis. Interaction between the CD4 receptor and the major histocompatibility complex class II molecule is important for T-cell activation. OBJECTIVE......: To test safety and efficacy of a fully human monoclonal anti-CD4 antibody (HuMax-CD4) in the treatment of psoriasis. DESIGN: Multicenter, double-blind, placebo-controlled, randomized clinical trial. Patients Eighty-five patients with moderate to severe psoriasis. INTERVENTIONS: Subcutaneous infusions...... dose level, 6 (38%) of 16 patients obtained more than 25% reduction of PASI and 3 (19%) obtained more than 50% reduction of PASI. A dose-dependent decrease in total lymphocyte count was seen and was parallel to a dose-dependent decrease in CD4+ T cells. This decrease was due to a decrease in the memory...

  11. El Paso Paul Kayser

    Energy Technology Data Exchange (ETDEWEB)

    1975-09-01

    The El Paso Paul Kayser, the world's largest LNG carrier, demonstrates not only the sophistication and skills of French shipbuilding technology but also the financial perils of the LNG game. Ordered along with 2 sister ships to transport LNG from Algeria to the US, the ship must now await the start-up of the new Kikda LNG plant, which has been delayed for an estimated 18 months. The Paul Kayser has a cargo capacity of 4.4 million cu ft, measures 922 ft overall, and has a deadweight of some 59,000 tons. The tanks were constructed according to the Gaz Transport technique using a double hull with Invar membranes. Labor involved with construction of the LNG tanks is estimated at 580,000 man-hr.

  12. Pengenalan Pose Tangan Menggunakan HuMoment

    Directory of Open Access Journals (Sweden)

    Dina Budhi Utami

    2017-02-01

    Full Text Available Computer vision yang didasarkan pada pengenalan bentuk memiliki banyak potensi dalam interaksi manusia dan komputer. Pose tangan dapat dijadikan simbol interaksi manusia dengan komputer seperti halnya pada penggunaan berbagai pose tangan pada bahasa isyarat. Berbagai pose tangan dapat digunakan untuk menggantikan fungsi mouse, untuk mengendalikan robot, dan sebagainya. Penelitian ini difokuskan pada pembangunan sistem pengenalan pose tangan menggunakan HuMoment. Proses pengenalan pose tangan dimulai dengan melakukan segmentasi citra masukan untuk menghasilkan citra ROI (Region of Interest yaitu area telapak tangan. Selanjutnya dilakukan proses deteksi tepi. Kemudian dilakukan ekstraksi nilai HuMoment. Nilai HuMoment dikuantisasikan ke dalam bukukode yang dihasilkan dari proses pelatihan menggunakan K-Means. Proses kuantisasi dilakukan dengan menghitung nilai Euclidean Distance terkecil antara nilai HuMomment citra masukan dan bukukode. Berdasarkan hasil penelitian, nilai akurasi sistem dalam mengenali pose tangan adalah 88.57%.

  13. Infecciones en huéspedes inmunocomprometidos

    OpenAIRE

    Cuéllar Ponce de León, Luis Ernesto

    2013-01-01

    Las infecciones son causa frecuente de morbimortalidad en huéspedes inmunocomprometidos. La frecuencia y diversidad de infecciones en esta población dependerá del tipo de inmunocompromiso, tratamiento recibido y aspecto epidemiológico. Los huéspedes con neutropenia desarrollan infecciones por bacterias extracelulares no encapsuladas y hongos levaduriformes y filamentosos; el diagnóstico precoz y tratamiento oportuno de las mismas son considerados una emergencia por su severidad y gran mortali...

  14. In Conversation with Paul Richards

    Science.gov (United States)

    Holman, Andrew

    2013-01-01

    Paul Richards is one of those individuals who make a difference and is as far from institutional as one can be. The author met up with him at the Learning Disability Today conference in London to talk more about his work and life. Paul coordinates the service user involvement across Southdown Housing Association, based in Sussex.

  15. Introduction: Reappraising Paul Feyerabend.

    Science.gov (United States)

    Brown, Matthew J; Kidd, Ian James

    2016-06-01

    This volume is devoted to a reappraisal of the philosophy of Paul Feyerabend. It has four aims. The first is to reassess his already well-known work from the 1960s and 1970s in light of contemporary developments in the history and philosophy of science. The second is to explore themes in his neglected later work, including recently published and previously unavailable writings. The third is to assess the contributions that Feyerabend can make to contemporary debate, on topics such as perspectivism, realism, and political philosophy of science. The fourth and final aim is to reconsider Feyerabend's place within the history of philosophy of science in the light of new scholarship. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Paul Graham, American Night

    Directory of Open Access Journals (Sweden)

    Catherine Bernard

    2006-12-01

    Full Text Available Le photographe britannique Paul Graham (1956- ne jouit pas encore en France de la notoriété de son compatriote Martin Parr et on ne peut, par conséquent, que se féliciter de voir l’une de ses plus puissantes séries — American Night — représentée à la Galerie Les Filles du Calvaire.Connu, avec Parr, pour avoir profondément influencé la photo documentaire anglaise en la faisant passer à la couleur avec virulence, Graham a été révélé il y a une vingtaine d’années par une série d’images prises à...

  17. Paul Lacoste, Portraits sensibles

    OpenAIRE

    Laplace-Treyture, Danièle

    2013-01-01

    Des vignerons indépendants et non pas coopérateurs ; des parcelles accrochées à des versants au lieu d’une vaste plaine viticole ; des vins certifiés bio et un vignoble en biodynamie... C’est autour de Jonquières et d’Aniane (communes situées entre Lodève et Montpellier), que Paul Lacoste a choisi de filmer un nouveau « tournant qualitatif » pris par la viticulture en Languedoc. Le documentaire (un feuilleton en six épisodes) bouscule quelque peu nos représentations collectives de ce Midi vit...

  18. PSI Paul Scherrer Institute

    International Nuclear Information System (INIS)

    Lefrancois, M.; Pladys, D.

    2008-05-01

    From research activities focused on civil and military uses of nuclear energy and developed after the second world war, the Paul Scherrer Institute (PSI) has been able to diversify its activities following 2 axis. First, the Gantry proton-therapy that is characterized by a compact equipment and an accurate 3-dimensional treatment of tumors (more than 260 patients have been treated by Gantry from 1996 to 2005). Secondly, new technologies in the fields of energy and transport. Nevertheless, PSI has been able to keep a high of valuation of its staff in nuclear engineering and materials that are the core of its activities. The main equipment of PSI are: -) SLS (Swiss Light Source): a synchrotron radiation source that is both a microscope and an X-ray source; -) SINQ: a neutron source based on spallation reactions; -)SμS: a muon source; and -) the Philips accelerator that is used in radiochemistry and the production of isotopes used for the treatment of eye tumors. PSI has established a large cooperation with French research laboratories on issues like: nuclear reactor safety, synchrotron radiation, the transmutation of nuclear wastes, the design of a source of ultra-cold neutrons, or the development of a hydrogen-fueled light vehicle. The total budget of PSI for 2007 reached 174.2 million euros. (A.C.)

  19. Paul Collier : Balancing beams

    CERN Multimedia

    2009-01-01

    As former head of AB Operations, Paul Collier and his group were in the ‘cockpit’ for the LHC’s maiden voyage - piloting the first beam around the ring. But now, as Head of the Beams Department, he will need his feet firmly on the ground in order to balance all the beam activities at CERN. "As Department Head, I’ll have less direct contact with the machines," Collier says with a hint of regret. "I’ll still obviously be very involved, but they won’t actually let me loose in front of the keyboard anymore!" As the new Head of the BE Department, Collier will be in charge of nearly 400 people, and will oversee all the beam activities, including the preparations for the longest period of beam operation in the history of CERN. In the new organization, the BE, TE and EN Departments have been grouped together in the Accelerator and Technology Sector. "‘Partnership’ is a key word for the three departments," says Collier. "The n...

  20. Paul Gauguin in Brittany

    Science.gov (United States)

    Asmus, John F.

    2009-07-01

    Ever since the dawn of the 20th Century there has been a universal consensus that Alphonse Mucha launched the sensation that became known as Art Nouveau. This event was associated with the appearance of his Gismonda poster promoting the Sarah Bernhardt play of that name in Paris in 1894. At an estate sale in 1954 a small collage bearing a likeness of Mucha's Gismonda was offered. It had been fabricated by gluing slivers cut from sixty postage stamps to a 20cm ceramic tile. Digital computer image enhancement was applied to the collage design, initials on a walking stick from the same estate collection, and the Mucha poster. These geometrical analyses revealed that the collage is more detailed than the Mucha "original". This led to our hypothesis that the famous poster was a hasty photographic plagiarism of the intricate ceramic-tile collage. Image analyses of the initials on the companion walking stick revealed conformity with the famous enigmatic "P GO" monogram of Paul Gauguin. We conclude that Gauguin rather than Mucha created the Gismonda composition. Historical evidence suggests that, while Gauguin was in Brittany recovering from injuries sustained in a fistfight, Annah la Javanese stole his possessions and took them to Paris where her next lover, Mucha, copied the collage and presented it as his original poster design.

  1. Paul Tillich and psychoanalysis.

    Science.gov (United States)

    Hart, Curtis W

    2011-09-01

    Paul Tillich (1886-1965) was one of the leading theologians of the twentieth century. Tillich was born in Germany and received his education and first academic appointments there. Tillich left Germany in 1933 to teach at Union Theological Seminary after having been dismissed from his university position by the National Socialist government for his radical views and political associations. In the United States, he became a highly successful lecturer, preacher, and public intellectual who reached numbers of persons who had departed or who had doubts regarding traditional religious belief and practice. Tillich underwent a series of traumatic losses in the early decades of his life that powerfully shaped his subsequent contributions to religious and cultural discourse. This essay outlines this pattern of loss and speculates about its impact upon his theological work. It lifts up Tillich's perspective of living and working "on the boundary" of disciplines, eras, and cultures, most particularly where psychoanalytic ideas contributed to his "theology of culture." It also stresses Tillich's role in initiating the ongoing dialogue between religion and psychiatry and psychoanalysis. The essay concludes with a summary critique of Tillich's work along with an affirmation of his considerable legacy. This essay was originally a presentation for the Richardson Research Seminar in the History of Psychiatry at Weill Cornell Medical College.

  2. A probabilistic Hu-Washizu variational principle

    Science.gov (United States)

    Liu, W. K.; Belytschko, T.; Besterfield, G. H.

    1987-01-01

    A Probabilistic Hu-Washizu Variational Principle (PHWVP) for the Probabilistic Finite Element Method (PFEM) is presented. This formulation is developed for both linear and nonlinear elasticity. The PHWVP allows incorporation of the probabilistic distributions for the constitutive law, compatibility condition, equilibrium, domain and boundary conditions into the PFEM. Thus, a complete probabilistic analysis can be performed where all aspects of the problem are treated as random variables and/or fields. The Hu-Washizu variational formulation is available in many conventional finite element codes thereby enabling the straightforward inclusion of the probabilistic features into present codes.

  3. James Peacock, Understanding Paul Auster

    Directory of Open Access Journals (Sweden)

    Chrysavgi Papayianni

    2011-10-01

    Full Text Available Paul Auster’s impressive gamut of work continues to incite fascination and controversy. Indeed, his compelling storytelling style taken together with his mixing of crime fiction and absurdism has made his readers and critics vacillate between praise and condemnation. James Peacock’s Understanding Paul Auster, sheds new light to otherwise obscure aspects of Auster’s novels, films, and other works undermining in this way the negative criticism of the past and thus creating a new appreciation fo...

  4. Paul Cézanne

    Directory of Open Access Journals (Sweden)

    Emile Bernard

    2009-01-01

    Full Text Available Bernard afirma (no final de seu texto ter escrito este artigo em Aix em março de 1904. Na realidade este deve ter tomado sua forma definitiva mais tarde, pois contém importantes citações tiradas das cartas de Cézanne datadas de 12 e 26 de maio. Embora seja conhecido pelos especialistas, este artigo (p. 17 a 30 no número de julho de 1904 do Occident foi algo eclipsado, nos estudos sobre Cézanne, pelos dois textos do Mercure de France que compõem os Souvenirs sur Paul Cézanne... e suas diversas reedições em forma de livro. O artigo do Occident é, em grande medida, consagrado às visões gerais de Bernard sobre a arte, mas, além da famosa compilação das opiniões de Cézanne, oferece citações aparentemente textuais do artista e algumas observações às vezes profundas sobre seus métodos de trabalho e sua evolução como pintor. Os comentários sobre Pissarro e o período de Auvers parecem exatos. Quanto à autenticidade das "opiniões", devemos ter em mente, por um lado, que Bernard se preocupa em assinalar, várias vezes, neste artigo, as ocasiões em que cita as próprias palavras de Cézanne e, por outro lado, que as "opiniões" propriamente ditas são enriquecidas com trechos de cartas, o que permite supor que a seção inteira seria composta de citações autênticas. P. M. DoranBernard claims (in the end of his text to have written this article in Aix in March 1904. Actually, it must have taken its final version later, since it contains important quotes drawn from Cézanne's letters of May 12 and 26. This article (pages 17 to 30 of the issue of July 1904 of Occident, although known among scholars, was somehow eclipsed, in the studies about Cézanne, by the two texts from Mercure de France which constitute the Souvenirs sur Paul Cézanne... and its various re-editions as a book. The article in Occident is mostly dedicated to Bernard's general views on art, but it offers, beyond the famous compilation of Cézanne's opinions

  5. Hu on poolel teel / James Miles

    Index Scriptorium Estoniae

    Miles, James

    2006-01-01

    2007. aastal toimuv kommunistliku partei 17. kongress tähistab Hiina presidendi Hu Jintao jaoks oma võimuaja poole peale jõudmist, ees ootavad sellised väljakutsed nagu olümpiamängude korraldamine, valimiskeeris Taiwanis ning hullunud majanduse stabiliseerimine. Vt samas: Hiina avanemise pidu

  6. Infecciones en huéspedes inmunocomprometidos

    Directory of Open Access Journals (Sweden)

    Luis Ernesto Cuéllar Ponce de León

    2013-04-01

    Full Text Available Las infecciones son causa frecuente de morbimortalidad en huéspedes inmunocomprometidos. La frecuencia y diversidad de infecciones en esta población dependerá del tipo de inmunocompromiso, tratamiento recibido y aspecto epidemiológico. Los huéspedes con neutropenia desarrollan infecciones por bacterias extracelulares no encapsuladas y hongos levaduriformes y filamentosos; el diagnóstico precoz y tratamiento oportuno de las mismas son considerados una emergencia por su severidad y gran mortalidad asociada. El compromiso de la inmunidad humoral se relaciona con infecciones por microorganismos encapsulados (bacterias extracelulares y hongos; la secuencia clínica presentada en estas infecciones es neumonía aguda-bacteremia/fungemia-meningoencefalitis aguda/crónica. Muchas de estas infecciones son inmunoprevenibles. Los huéspedes con compromiso de la inmunidad celular desarrollan infecciones por microorganismos intracelulares y también por algunos extracelulares; muchas de las infecciones ocurren por reactivación; a menudo requieren profilaxis antimicrobiana tanto primaria como secundaria. El tratamiento medicamentoso (quimioterapia, drogas inmunosupresoras, etc. y los procedimientos invasivos facilitan el desarrollo de determinadas infecciones. El aspecto epidemiológico, que incluye el estilo de vida, ocupación, viajes previos, etc. permite evaluar y determinar el riesgo de potenciales infecciones. En conclusión, la prevención de las infecciones y el uso racional de antimicrobianos son los pilares fundamentales en el manejo efectivo de los huéspedes inmunocomprometidos.

  7. Paul Beynel (1944-2012)

    CERN Multimedia

    2012-01-01

    Paul joined the Radiation Group at CERN's Laboratory II in March 1972. He carried out tests on materials and components that were used in the construction of the SPS.   Following the commissioning of the SPS in 1975 and when the two laboratories were merged into one, Paul became a member of the Radiation Protection group. There, he had two roles: the first as a radiation protection officer in the underground areas, where access and personnel protection issues were of crucial importance; and the second testing the radioresistance of many different types of materials. Thanks to his detailed analyses and shrewd interpretation of the results, he became a recognised expert in the field - a recognition that extended far beyond the boundaries of CERN.  He wrote many reports and co-authored several volumes of the CERN "yellow reports" issued as a catalogue on the radioresistance of materials and which continue to serve as reference works today. In July 1988 Paul ha...

  8. The intermediate state in Paul

    Directory of Open Access Journals (Sweden)

    N. S. L. Fryer

    1987-01-01

    Full Text Available The point of view taken in this paper is that the apostle Paul envisions, between death and the resurrection of the body at the Parousia, an interim period during which the disembodied soul is in the immediate presence of Christ, though in a state of 'nakedness'. The background of Paul's view lies neither in contemporary Hellenistic religious-philosophical speculations nor in 'late-Judaism'. Two crucial 'forces' in particular moulded his perspective, viz the teachings of Jesus and His own rapture to 'Paradise'.

  9. Paul Garrin / Paul Garrin ; interv. Tilman Baumgärtel

    Index Scriptorium Estoniae

    Garrin, Paul

    2006-01-01

    1997. a. New York Citys tehtud intervjuu ameerika kunstniku, firma pgMedia rajaja ja omaniku Paul Garriniga (sünd. 1952). P. Garrini videotest, pikemalt videost "Free Society", Internetiga tegelemisest, projektist "Mediafilter", interaktiivsetest installatsioonidest, domeeninimede registreerimise projektist "name.space"

  10. Dirac, Prof. Paul Adrien Maurice

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1935 Honorary. Dirac, Prof. Paul Adrien Maurice Nobel Laureate (Physics) - 1933. Date of birth: 8 August 1902. Date of death: 20 October 1984. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  11. Paul Dirac lectures at CERN

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    When a group of physicists entered the Main Auditorium, during the evening of 29 June, they felt they had opened a time portal.   Paul Dirac in front of a blackboard showing his formula. ©Sandra Hoogeboom An attentive audience, dressed in early 1900 costumes, were watching a lecture by the elusive Paul Dirac, presenting for the first time his famous formula on the blackboard. Paul Adrien Maurice Dirac (1902-1984) was a British mathematical physicist at Cambridge, and one of the "fathers" of quantum mechanics. When he first wrote it, in 1928, Dirac was not sure what his formula really meant. As demonstrated by Andersson four year later, what Dirac had written on the blackboard was the first definition of a positron, hence he is credited with having anticipated the existence of antimatter. The actor John Kohl performs as Paul Dirac. ©Sandra Hoogeboom What the group of puzzled physicists were really observing when they entered the CERN Auditorium was the shoo...

  12. "Paul Revere's Ride": Awakening Abolitionists

    Science.gov (United States)

    Lepore, Jill

    2011-01-01

    Henry Wadsworth Longfellow used to be both the best-known poet in the English-speaking world and the most beloved, adored by the learned and the lowly alike, read by everyone from Nathaniel Hawthorne and Abraham Lincoln to John Ruskin and Queen Victoria--and, just as avidly, by the queen's servants. "Paul Revere's Ride" is Longfellow's best-known…

  13. Karjas on ohutum elada / Toomas Paul

    Index Scriptorium Estoniae

    Paul, Toomas, 1939-

    2003-01-01

    Vt. ka Paul, Toomas. "Löö esimesena, Freddy!". Eesti Päevaleht, 8. mai 2003. Inimesest kui karjaloomast, inimloomusest ja sallivusest. Ilm. ka: Paul, Toomas. Ole salliv, Bob // Pastishsh & popurrii : ilmavaatlusi / Paul, Toomas. - [Tallinn] : Oomen, 2007. - Lk. 54-58

  14. Paul Bouchardy (1937 – 2012)

    CERN Multimedia

    2012-01-01

    It is with great sorrow that we announce the sudden passing of our former colleague and friend, Paul Bouchardy, on Friday 17 February.   An outstanding travel agent, well-respected and active within his profession (he was in charge of apprenticeships for the Association of Geneva Travel Agencies - AGAV), Paul was director of the Carlson Wagonlit agency at CERN for many years. He knew the world like the back of his hand, and many people have benefited from his vast knowledge and expert tourist advice. Key figure in the Laboratory since the 1970’s, he retired in 2002 after 38 years with Carlson Wagonlit, including more than 30 years of on-site service to the CERN community. In these difficult days, our thoughts are with his wife and children and grandchildren, the family he cherished above all else and who accompanied him until embarking on his final journey. His friends and former colleagues at CERN

  15. Kritik Nalar Hermeneutika Paul Ricoeur

    Directory of Open Access Journals (Sweden)

    Daden Robi Rahman

    2016-03-01

    Full Text Available Hermeneutics was born and developed in the West, specifically in response to the theological problem of Christianity, and always claimed to be an effective solution to the interpretation of Scripture. With existence of various schools, hermeneutics has also various shades and resulted different interpretations. Such as Schleiermacher, followed by Wilhelm Dilthey and Emilio Betti as initiators of hermeneutics methodology. Martin Heidegger and Gadamer followed with their ontological hermeneutics, and continued by Habermas with his critical hermeneutics. After that, the critical ontological hermeneutics initiated by either Paul Ricoeur, or Rudolf Bultman with his theological hermeneutics, and Derrida with his deconstructive hermeneutics. Among those schools, the writers interested in reviewing the hermeneutics of Paul Ricoeur which represents a distinctive theory of interpretation. His idea considered to be a bridge of the fierce debate between methodological traditions and philosophical traditions represented by Emilio Betti and Hans Georg Gadamer. The thought of Ricoeur was also claimed as a mediator between the positions of the romantic tradition of Schleiermacher and Dilthey with philosophy hermeneutic by Martin Heidegger. In another side, he was placed as a combination between the two great philosophical tradition, that’s German phenomenology and France structuralism. Furthermore, the thought of Ricoeur is a revision to the thought of Dilthey about explanation (erklären and understanding (verstehen. Through this paper, the writer will attempt to unravel the thought of Paul Ricoeur, and in the end, will clearly known the position of Ricoeur among other hermeneutics initiators.

  16. Was Paul among the contemplatives?

    Directory of Open Access Journals (Sweden)

    James Panaggio

    2016-09-01

    Full Text Available This article offers a critique of the contemporary Contemplative Tradition’s view of spiritual transformation from the lens of the universally accepted letters of Paul. The article argues that contemporary contemplatives, especially Dallas Willard and Richard Foster, differ from Paul in three principle areas. Firstly, whereas Paul’s concept of transformation is based largely on objective realities, representatives of the Contemplative Tradition tend to focus on subjective realities. Secondly, contemporary contemplatives view transformation as coming as one imitates the life of Christ, his daily disciplines and activities, whereas Paul’s view centres on the death of Christ as foundational to the Christian’s identity and thus vital to the way they live out their faith. Finally, the cornerstone of the contemporary Contemplative Tradition’s view of spiritual transformation is the belief that the essential means by which transformation takes place is engagement in the spiritual disciplines. It is argued that many of the activities that are denominated as ‘spiritual disciplines’ are not in fact ‘transformative’ activities, and thus do not fit the category of spiritual disciplines. Furthermore, this study insists that Paul seldom links the practice of the disciplines with the means of transformation, offering instead five examples of specific means of transformation that flow out of Paul’s accepted letters.

  17. Paul Levaux (1931-2012)

    CERN Multimedia

    2012-01-01

    Mr Paul Levaux, a long-standing member of the Belgian delegation to the Finance Committee and Council, passed away on 3 December 2012.   Paul Levaux first attended the CERN Council and Finance Committee in June 1970 as an Advisor, although his association with CERN goes back to the 1960s. From October 1970 until December 2007 he represented Belgium in the capacity of Council and Finance Committee delegate. He was Finance Committee Chairman from 1971 to 1973 and President of Council from 1975 to June 1978. He also served as Vice-President of Council from January 1978 until December 1980 with a second term from January 1994 to December 1997. In addition to holding these important offices, Paul Levaux participated in an extensive number of CERN working groups. In particular, he was a member of the Working Group on Procedures for Payment of Member States' Contributions (2000-2001) and Working Group on the Review of the Tasks and Working Methods of CERN's Governing Bodies and Commi...

  18. Head as metaphor in Paul

    Directory of Open Access Journals (Sweden)

    A. Wolters

    2011-06-01

    Full Text Available Since the 1980s there has been a debate among New Testament scholars about the meaning of the Greek word “kephalē” (“head” in the Pauline epistles. Some scholars defend the traditional view that it means “leader”, while others argue that it should be understood to mean “source”. One result of this debate is that it is now clear that both the traditional and the new interpretation of kephalē have very little support in general Greek usage before the New Testament. This article seeks to advance the debate by showing that the phenomenon of “semantic borrowing” can explain why the meaning “source” is effectively limited to one passage in Herodotus,and the meaning “leader” is only found in Greek works written by bilingual Jews. The passage in Herodotus probably reflects a semantic loan from Old Persian *sar while various places in the Septuagint, Philo, Josephus and Paul reflect a semantic loan from Hebrew “ro’sh” (or Aramaic “re’sh”. Because the latter semantic loan (“head” meaning “leader” is embedded in the Greek Bible (both in the Septuagint and Paul,the authority and prestige of the latter can account for the fact that the new meaning of kephalē, though unknown in previous pagan Greek writings, gradually became widespread in postbiblical Greek as Christianity spread.

  19. Notas sobre el paisaje de Huánuco Pampa

    OpenAIRE

    Román Godines, Oscar; Ministerio de Cultura

    2013-01-01

    El complejo arqueológico Huánuco Pampa se encuentra ubicado en la provincia Dos de Mayo en el departamento de Huánuco y en la actualidad es quizás el principal vestigio de la cosmovisión y la planificación urbana inca.

  20. Sparks sädeleb Rabarocki öös. Ettevaatust! Eliidi rünnak. Hu? Hu da hell?

    Index Scriptorium Estoniae

    2007-01-01

    Ameerika ansamblist Sparks. Vaiko Eplik & Eliit heliplaatidest "1: Aastaajad", "2: Aastaajad" ja "3: Kosmoseodüsseia", esinemisest festivalil Rabarock. Hannaliisa Uusma, Leslie Da Bassi ja DJ Criticali projektist HU?, singlitest "Kosmos" ja "Absoluutselt" (Rabarockil esitusel materjal HU? debüütalbumilt "Film")

  1. Ära pabista, Sam! / Toomas Paul

    Index Scriptorium Estoniae

    Paul, Toomas, 1939-

    2003-01-01

    Inimese võimest leida lohutust täieliku lootusetuse olukorras ja võimetusest ette näha, milliste tulemusteni tema tegevus lõpuks viib. Ilm. ka: Paul, Toomas. Riskiveski krigin // Pastishsh & popurrii : ilmavaatlusi / Paul, Toomas. - [Tallinn] : Oomen, 2007. - Lk. 133-139

  2. Interview : Paul Paulus on group creativity

    NARCIS (Netherlands)

    Harms, Rainer; Van Der Zee, Karen

    Paul Paulus is Distinguished Professor of Psychology at the Department of Psychology, University of Texas at Arlington. Paul Paulus's research interests revolve around Group Creativity: On the one hand, creative processes are often conceptualized as individual-level phenomena. On the other hand,

  3. Interview: Paul Paulus on group creativity

    NARCIS (Netherlands)

    Harms, Rainer; van der Zee, Karen

    2013-01-01

    Paul Paulus is Distinguished Professor of Psychology at the Department of Psychology, University of Texas at Arlington. Paul Paulus's research interests revolve around Group Creativity: On the one hand, creative processes are often conceptualized as individual-level phenomena. On the other hand,

  4. PSI Paul Scherrer Institute; PSI Institut Paul Scherrer

    Energy Technology Data Exchange (ETDEWEB)

    Lefrancois, M.; Pladys, D

    2008-05-15

    From research activities focused on civil and military uses of nuclear energy and developed after the second world war, the Paul Scherrer Institute (PSI) has been able to diversify its activities following 2 axis. First, the Gantry proton-therapy that is characterized by a compact equipment and an accurate 3-dimensional treatment of tumors (more than 260 patients have been treated by Gantry from 1996 to 2005). Secondly, new technologies in the fields of energy and transport. Nevertheless, PSI has been able to keep a high of valuation of its staff in nuclear engineering and materials that are the core of its activities. The main equipment of PSI are: -) SLS (Swiss Light Source): a synchrotron radiation source that is both a microscope and an X-ray source; -) SINQ: a neutron source based on spallation reactions; -)S{mu}S: a muon source; and -) the Philips accelerator that is used in radiochemistry and the production of isotopes used for the treatment of eye tumors. PSI has established a large cooperation with French research laboratories on issues like: nuclear reactor safety, synchrotron radiation, the transmutation of nuclear wastes, the design of a source of ultra-cold neutrons, or the development of a hydrogen-fueled light vehicle. The total budget of PSI for 2007 reached 174.2 million euros. (A.C.)

  5. Quantitative assessment of periimplant bone density (HU) on CBCT image

    International Nuclear Information System (INIS)

    Goo, Jong Gook; Kim, Jin Soo; Kim, Jae Duk

    2008-01-01

    The primary aims of this retrospective study were to compare subjective bone quality and bone quality based on the Hounsfield scale in different segments of the edentulous jaw, and to establish quantitative and objective assessment of the bone quality. Twenty eight randomly selected cone-beam computed tomographic (CBCT) scans were analyzed. For evaluation one hundred and twelve edentulous areas were selected. Implant recipient sites were evaluated visually for Lekholm and Zarb classification. The same sites were subsequently evaluated digitally using the Hounsfield scale with Vimplant 2.0 TM , and the results were correlated with visual classification. Data was subject for statistical analysis in order to determine correlation between recorded HU and the regions of the mouth with the Kruskal-Wallis test. The highest unit/mean density value (311 HU) was found in the anterior mandible, followed by 259 HU for the posterior mandible, 216 HU for the anterior maxilla, and 127 HU for the posterior maxilla. These results demonstrate a strong correlation for HU depending on the region of the mouth (p TM with Vimplant TM software.

  6. Literature in focus: Paul Ginsparg

    CERN Multimedia

    2008-01-01

    Paul Ginsparg, professor of physics, computing and information science at Cornell University, is best known as the creator of an online system for distributing scientific research results. Known by scientists around the world as "arXiv.org", the system was designed to distribute electronic copies of the preprints that until 17 years ago were all distributed on paper and shipped in their thousands by the postal services. Ginsparg, at the time based at Los Alamos, carried out this work in his spare time using surplus equipment! It is amusing to look backwards and observe how this new technology was perceived in the beginning: In early 1994 Ginsparg happened to serve on a committee advising the American Physical Society (APS) about putting Physical Review Letters online. He suggested that a Web interface along the lines of the xxx.lanl.gov prototype might be a good way for the APS to disseminate its documents. A response came back from another committee member: "Installing and learni...

  7. Point of view: Paul Simon.

    Science.gov (United States)

    Simon, P

    1999-02-01

    In this article, former US Senator Paul Simon notes that, in his lifetime, the population of the world has tripled and is expected to quadruple. Among the effects of this population growth will be a 55% increase in nitrate emissions that will feed algae and compromise fish supplies. The US was extremely short-sighted when it reduced funding for the international family planning (FP) programs that benefit all nations. False accusations that the UN Population Fund (UNFPA) operates with a "bloated bureaucracy" ignore the fact that this agency has only 166 employees. More appropriate criticism would assert that the task the UNFPA is trying to accomplish is too important and too vast for such a small staff. Without FP programs, earth would now have to support an additional 400 million people. While contraceptive use by married women in developing countries has increased from 10% in 1965 to above 50% today and life expectancy is increasing, we must recognize the fact that we are currently unable to provide most of the world's population with safe water and sanitation and that increased population size will only exacerbate this problem. Encouraging voluntary FP is humanitarian and prudent and will help protect the entire population of the world.

  8. Notes on Paul Kuimet / Pille Epner

    Index Scriptorium Estoniae

    Epner, Pille

    2011-01-01

    Fotograaf Paul Kuimetist, tema loomingust, Tallinnas Hobusepea galeriis toimunud isikunäitusest "In Vicinity" (2010), mis uuris valglinnastumist, kohaspetsiifilisest installatsioonist "Untitled" (2010) ja näitusest "Not Necessarily So" (koos Laura Tootsiga, 2010) Linzis

  9. Location - Managed Facility - St. Paul District (MVP)

    Data.gov (United States)

    Army Corps of Engineers, Department of the Army, Department of Defense — St. Paul District - US Army Corps of Engineers Managed Facility locations. District headquarters, Natural Resource, Recreation, Lock and Dam, and Regulatory offices...

  10. Paul Feyerabend: Science and the Anarchist.

    Science.gov (United States)

    Science, 1979

    1979-01-01

    Presents comments on the arguments of Paul Feyerabend toward progression science. The positions held by this philosopher of science are given with accompanying remarks from other philosophers and historians. (SA)

  11. Eestis meenutati Paul Kerest / Kalev Vilgats

    Index Scriptorium Estoniae

    Vilgats, Kalev

    2011-01-01

    Paul Kerese 95. sünniaastapäeva puhul viibisid Tallinnas male eksmaailmameister Anatoli Karpov ja teised malemaailma tipud. President Toomas Hendrik Ilves kohtus male suurkujudega Kadriorus 6. jaan. 2011

  12. WHAT HAPPENED TO THE GALATIAN CHRISTIANS? PAUL'S ...

    African Journals Online (AJOL)

    Paul's Letter to the Galatians points to the influence of his missionary ... of the apostle's name in the first four centuries. .... Acta Theologica Supplementum 19. 2014 .... The author states that they spoke the word in Perge, not implying that they.

  13. [Lea Kõiv. Paul Johansen und das Stadtarchiv Reval/Tallinn] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2008-01-01

    Arvustus: Lea Kõiv. Paul Johansen und das Stadtarchiv Reval/Tallinn. - Nordosteuropa als Geschichtsregion. Helsinki : Aue-Stiftung; Lübeck : Schmict-Röhmild, 2006. Lk. 45-59. Artiklis on kasutatud seni avalikkusele vähetuntud materjale ja osaliselt käsitletud avalikke vaidlusi, kuhu olid segatud nii Paul Johansen kui järgmine linnaarhivaar Rudolf Kenkmaa

  14. Subunit-specific phenotypes of Salmonella typhimurium HU mutants.

    OpenAIRE

    Hillyard, D R; Edlund, M; Hughes, K T; Marsh, M; Higgins, N P

    1990-01-01

    Salmonella hupA and hupB mutants were studied to determine the reasons for the high degree of conservation in HU structure in bacteria. We found one HU-1-specific effect; the F'128 plasmid was 25-fold less stable in hupB compared with hupA or wild-type cells. F' plasmids were 120-fold more unstable in hupA hupB double mutants compared with wild-type cells, and the double mutant also had a significant alteration in plasmid DNA structure. pBR322 DNA isolated from hupA hupB strains was deficient...

  15. Major Additions to the Linus Pauling Canon

    Science.gov (United States)

    Davenport, Derek A.

    2002-08-01

    The National Library of Medicine has also just posted a Web site on Linus Pauling in its Profiles of Science series. While by no means as rich as the various Oregon State University sites, it is well worth visiting. There are texts of various speeches (including his Nobel address), many downloadable photographs, correspondence (including a poignant letter to James Watson and Francis Crick concerning their "rival" structures for DNA), and much else besides. There is a certain irony in Linus Pauling being honored by the National Library of Medicine. Ever since his 1949 presidential address to the American Chemical Society, and perhaps earlier, Pauling had been at loggerheads, sometimes acrimoniously so, with the medical establishment. It is easy to imagine him somewhere in the timeless infinitude of the empyrean sporting his characteristic ear-to-ear grin.

  16. Paul D. Sturkie: Avian cardiac physiologist.

    Science.gov (United States)

    Bello, Nicholas T; Cohick, Wendie S; McKeever, Kenneth H; Malinowski, Karyn

    2018-06-01

    Sturkie's Avian Physiology is a highly regarded textbook for the study of comparative poultry physiology. Less well known, however, is the contribution of Paul D. Sturkie (1909-2002) as a pioneer in the experimental physiology of avian species. His seminal research on the cardiovascular and hemodynamic controls of chickens and egg-laying hens had a notable impact on the poultry industry and breeding practices of farmers. The purpose of this article is to highlight the contributions and practical insights of Paul D. Sturkie to the field of poultry science.

  17. Abundances of the planetary nebula Hu 1-2

    NARCIS (Netherlands)

    Pottasch, [No Value; Hyung, S; Aller, LH; Beintema, DA; Bernard-Salas, J; Feibelman, WA; Klockner, HR

    The ISO and IUE spectra of the "elliptical" nebula Hu 1-2 are presented. These spectra are combined with new, high resolution spectra in the visual wavelength region to obtain a complete, extinction corrected, spectrum. The chemical composition of the nebula is then calculated and compared to

  18. Classical Sax: Conversation with Paul Brodie.

    Science.gov (United States)

    Row, David W.

    1984-01-01

    Paul Brodie, the most recorded concert saxophonist in the history of the instrument, talks about a number of topics, including his career, differences among saxophonists, mixing styles of playing, the effectiveness of music schools, and whether it is necessary to understand the structure of the piece being played. (RM)

  19. Parallel Narrative Structure in Paul Harding's "Tinkers"

    Science.gov (United States)

    Çirakli, Mustafa Zeki

    2014-01-01

    The present paper explores the implications of parallel narrative structure in Paul Harding's "Tinkers" (2009). Besides primarily recounting the two sets of parallel narratives, "Tinkers" also comprises of seemingly unrelated fragments such as excerpts from clock repair manuals and diaries. The main stories, however, told…

  20. Paul van Ostaijen en het primitivisme

    NARCIS (Netherlands)

    Laan, N.

    2010-01-01

    Though Paul van Ostaijen has always been put within the context of the historical avant-garde, his relationship to primitivism has never been the subject of study. That is strange, for primitivism is commonly seen as one of the defining characteristics of the avant-garde. Even stranger is that

  1. Walking Between Houses, Paul Julien in Sudan

    NARCIS (Netherlands)

    Elsadig Mohamed; Andrea Stultiens

    2015-01-01

    April 2015 Sudanese photographer Elsadig Mohamed and I tried to relate the photographs that Paul Julien made when traveling through the country in 1933 and 1948 to stories and realities alive in present day Sudan. This initial research was pretty successful and we thought a first presentation of the

  2. Paul Goodman Redux: Education as Apprenticed Anarchism

    Science.gov (United States)

    Holowchak, M. Andrew

    2010-01-01

    When talk of philosophy of pedagogy comes up today, it is common to hear the names of Aristotle, Thomas Jefferson, John Dewey, or Paulo Freire, but the name of Paul Goodman, who campaigned vigorously for pedagogical reform much of his life, is seldom mentioned. In spite of neglect of his work, Goodman had much to say on pedagogical practice that…

  3. Walking between houses, Paul Julien in Sudan

    NARCIS (Netherlands)

    Stultiens, Andrea; Mohamed, Elsadig

    2015-01-01

    April 2015 Sudanese photographer Elsadig Mohamed and I tried to relate the photographs that Paul Julien made when traveling through the country in 1933 and 1948 to stories and realities alive in present day Sudan. This initial research was pretty successful and we thought a first presentation of the

  4. Vasks: Cantabile per archi, Paul Mägi / Bernhard Uske

    Index Scriptorium Estoniae

    Uske, Bernhard

    1994-01-01

    Uuest heliplaadist "Vasks: Cantabile per archi; Botschaft: Musica Dolorosa, Sinfonie für Streicher (Stimmen). Latvijas Nicionalais Simfoniskais Orkestris, Latvijas Filharmonijas Kamerorkestris. Pauls Megi [Paul Mägi]", Tovijs Lifsics. Wergo CD 6220-2

  5. Paul Pinna avab Estonia Talveaias omanimelise baari / Christel Karits

    Index Scriptorium Estoniae

    Karits, Christel, 1966-

    2006-01-01

    Rahvusooper Estonia sajanda sünnipäeva puhul etendub 12. ja 13. septembril Estonia Talveaias lavastus "Paul Pinnat otsimas". Tekst on 95% osas Paul Pinna ja Karl August Hindrey sulest, dramatiseeris ja lavastas Heidi Sarapuu

  6. Globaalne Paul Goble : " Lähituleviku suhtes olen pessimist" / Paul A. Goble ; interv. Teet Korsten

    Index Scriptorium Estoniae

    Goble, Paul Alan, 1949-

    2004-01-01

    Ilmunud ka: Severnoje Poberezhje, 18. sept. 2004, lk. 5. Kõrgetes USA valitsusametites teeninud sovetoloog Paul Goble, kes asus alaliselt elama Tartusse, räägib sidemetest Eestiga, huvist sovetoloogia vastu, endast. Vt. samas: 13 küsimust

  7. Targeting Mycobacterium tuberculosis nucleoid-associated protein HU with structure-based inhibitors

    Science.gov (United States)

    Bhowmick, Tuhin; Ghosh, Soumitra; Dixit, Karuna; Ganesan, Varsha; Ramagopal, Udupi A.; Dey, Debayan; Sarma, Siddhartha P.; Ramakumar, Suryanarayanarao; Nagaraja, Valakunja

    2014-06-01

    The nucleoid-associated protein HU plays an important role in maintenance of chromosomal architecture and in global regulation of DNA transactions in bacteria. Although HU is essential for growth in Mycobacterium tuberculosis (Mtb), there have been no reported attempts to perturb HU function with small molecules. Here we report the crystal structure of the N-terminal domain of HU from Mtb. We identify a core region within the HU-DNA interface that can be targeted using stilbene derivatives. These small molecules specifically inhibit HU-DNA binding, disrupt nucleoid architecture and reduce Mtb growth. The stilbene inhibitors induce gene expression changes in Mtb that resemble those induced by HU deficiency. Our results indicate that HU is a potential target for the development of therapies against tuberculosis.

  8. Paul Henning Krogh on Soil Ecotoxicology

    DEFF Research Database (Denmark)

    Krogh, Paul Henning

    2008-01-01

    In a recent analysis of data from Essential Science Indicators SM from Thomson Reuters , Dr. Paul Henning Krogh was named a Rising Star in the field of Environment & Ecology. His current record in this field includes 48 papers cited a total of 410 times. Dr. Krogh is a Senior Scientist in the Dep......In a recent analysis of data from Essential Science Indicators SM from Thomson Reuters , Dr. Paul Henning Krogh was named a Rising Star in the field of Environment & Ecology. His current record in this field includes 48 papers cited a total of 410 times. Dr. Krogh is a Senior Scientist...... in the Department of Terrestrial Ecology at the National Environmental Research Institute, part of the University of Aarhus in Silkeborg, Denmark. This month, he talks with ScienceWatch.com correspondent Simon Mitton about his highly cited work. View Article...

  9. Designing of a Quadrupole Paul Ion Trap

    Science.gov (United States)

    Kiyani, Abouzar; Abdollahzadeh, M.; Sadat Kiai, S. M.; Zirak, A. R.

    2011-08-01

    The ion motion equation in a Paul ion trap known as Mathieu differential equation has been solved for the first time by using Runge-Kutta methods with 4th, 6th, and 8th orders. The first stability regions in az - qz plane and the corresponding qmax values were determined and compared. Also, the first stability regions of , , , ions in the Vdc - Vac plane were drown, and the threshold voltages for the ion separation was investigated.

  10. Exhibition: Linus Pauling and the Twentieth Century

    CERN Document Server

    2003-01-01

    On April 28 the exhibit Linus Pauling and the Twentieth Century organised by UNIDIR (United Nations Institute for Disarmament Research) and SGI (Soka Gakkai International) as well as with the contributions of CERN and the University of Geneva, opened at the United Nations Office of Geneva. Linus Pauling is the only person to date to have won two unshared Nobel Prizes: Chemistry in 1954 and Peace in 1962. The first was awarded for his landmark research on the nature of the chemical bond and its application in understanding the structure of complex substances. The second one acknowledged his courageous protest against atmospheric nuclear testing and his championship of international peace. The exhibit, for audience of all ages, traces seven decades of Linus Pauling's life and influence on the 20th century. Before starting its European tour at the UNESCO headquarters in Paris, the exhibit opened in 1998 in San Francisco and then travelled within the United-States and to Japan with an attendance of more than one...

  11. Exhibition: Linus Pauling and the Twentieth Century

    CERN Document Server

    2003-01-01

    On April 28 the exhibit Linus Pauling and the Twentieth Century organised by UNIDIR (United Nations Institute for Disarmament Research) and SGI (Soka Gakkai International) as well as with the contributions of CERN and the University of Geneva, opens at the United Nations Office of Geneva. Linus Pauling is the only person to date to have won two unshared Nobel Prizes: Chemistry in 1954 and Peace in 1962. The first was awarded for his landmark research on the nature of the chemical bond and its application in understanding the structure of complex substances. The second one acknowledged his courageous protest against atmospheric nuclear testing and his championship of international peace. The exhibit, for all ages' audiences, traces seven decades of Linus Pauling's life and influence on the 20th century. Before starting its European tour at the UNESCO headquarters in Paris, the exhibit opened in 1998 in San Francisco and then travelled within the United-States and to Japan with an attendance of more than one m...

  12. Paul Falk-Vairant, 1921-2001

    CERN Multimedia

    2001-01-01

    Paul Falk-Vairant died on 9 March 2001, a few weeks before his eightieth birthday. A physicist with dual Swiss and French nationality, he left his mark on particle physics in France and had a great impact on the development of CERN. Educated at the Swiss Federal Polytechnic at Zürich, Paul Falk-Vairant arrived in France in 1947 to study for a thesis at the Radium Institute in Paris. Up until 1973, he was employed successively by the French CNRS, CEA and the University of Paris. During the same period, he came to lead the first experiment at CERN run by physicists from outside institutes at the PS. In 1971, he chaired the ECFA (European Committee for Future Accelerators) working group on SPS physics. It was therefore natural for CERN in 1972 to invite him to take over its research policy. From 1973 to 1976, he occupied the position of Director of Physics I Department at CERN before becoming Research Director for the whole of CERN until 1978. At the same time Paul Falk-Vairant guided the experimental...

  13. Neutron radiography at the Paul Scherrer Institute

    International Nuclear Information System (INIS)

    Pleinert, H.; Lehmann, E.; Hammer, J.

    1994-01-01

    Neutron radiography provides an efficient tool of measurement for many applications in fundamental research as well as in industrial non-destructive testing (NDT). A neutron radiography program has been initiated at the Paul Scherrer Institute and implemented since 1992. From the beginning of 1992 until the end of 1993, a neutron facility has been in operation at the SAPHIR research reactor. Several applications have been tested and programs on two main fields of application have been established, focusing on the study of porous materials, especially concrete and granitic rock. The investigations on concrete and other building materials are carried out in cooperation with the Swiss Federal Institute of Technology in Zurich. The experimental activities are currently carried out at the Atominstitute of the Austrian Universities in Vienna, in the framework of a cooperation program with the Atominstitute. The continuation of the activities on a new radiography facility at the spallation source SINQ is planned at the Paul Scherrer Institute. In the following an overview of the method, of the actual and potential applications of neutron radiography at the Paul Scherrer Institute is given. (author) 6 figs., 1 tab., 3 refs

  14. Obituary: Paul Barr, 1955-2005

    Science.gov (United States)

    Parmar, Arvind

    2007-12-01

    Paul Barr, an extragalactic astronomer and spacecraft mission planner, died on 19 October 2005 at his home in Noordwijk, the Netherlands, at the age of 50. Although his scientific interests ranged from AGN to X-ray binaries, he will perhaps best be remembered for his mission planning skills on EXOSAT, ISO, and Integral. Many hundreds of observers have benefited from his ability to juggle seemingly impossible observing constraints and arrive at the optimum observing program. A rare talent. Barr was born in Sunderland, England, on 28 July 1995. After attending Saint Aidans Grammar School, where his father was the headmaster, he obtained his Bachelors Degree in astronomy from the University of London (June 1976) before moving to the Mullard Space Science Laboratory. There he obtained his Doctorate in X-ray astronomy in February 1980, using data from the Ariel V and Copernicus satellites. After a Post-Doctoral position at London University, where he did research into ultra-violet emission from AGN and X-ray binaries using IUE, Paul joined ESA in 1983. He worked on a wide range of missions including EXOSAT, ISO, and Integral. These observatories spanned the wavelength range from the Infra-red to the gamma-ray, giving insight into Paul's flexibility and ability to contribute in many areas. On ISO, Paul oversaw the scientific development and use of the very successful observation scheduling system — this topic became his specialty. As ISO operations became routine, he took up the challenge of space-borne gamma-ray astronomy and moved in 1997 to Integral where he worked in the Science Operation Centre (ISOC), at ESTEC in the Netherlands, as senior mission planner. He worked with the gamma-ray imager (IBIS) instrument team to ensure that operations of their instrument were properly supported by ESA and supported preparations of announcements of opportunity. In early 2005 the ISOC moved to Europe's Space Astronomy Centre (ESAC) just outside Madrid, Spain. Paul, however

  15. Cytoplasmic Hu-Antigen R (HuR) Expression is Associated with Poor Survival in Patients with Surgically Resected Cholangiocarcinoma Treated with Adjuvant Gemcitabine-Based Chemotherapy.

    Science.gov (United States)

    Toyota, Kazuhiro; Murakami, Yoshiaki; Kondo, Naru; Uemura, Kenichiro; Nakagawa, Naoya; Takahashi, Shinya; Sueda, Taijiro

    2018-05-01

    Hu-antigen R (HuR) is an RNA-binding protein that regulates the stability, translation, and nucleus-to-cytoplasm translocation of messenger RNAs (mRNAs). The aim of this study was to investigate the prognostic significance of HuR in cholangiocarcinoma patients who received adjuvant gemcitabine-based chemotherapy (AGC) after surgical resection. Nuclear and cytoplasmic HuR expression was investigated immunohistochemically in 131 patients with resected cholangiocarcinoma, including 91 patients administered AGC and 40 patients who did not receive adjuvant chemotherapy. The correlation between HuR expression and survival was evaluated by statistical analysis. High nuclear and cytoplasmic HuR expression was observed in 67 (51%) and 45 (34%) patients, respectively. Cytoplasmic HuR expression was significantly associated with lymph node metastasis (p < 0.01), while high cytoplasmic HuR expression was significantly associated with poor disease-free survival [DFS] (p = 0.03) and overall survival [OS] (p = 0.001) in the 91 patients who received AGC, but not in the 40 patients who did not receive AGC (DFS p = 0.17; OS p = 0.07). In the multivariate analysis of patients who received AGC, high cytoplasmic HuR expression was an independent predictor of poor DFS (hazard ratio [HR] 1.77; p = 0.04) and OS (HR 2.09; p = 0.02). Nuclear HuR expression did not affect the survival of enrolled patients. High cytoplasmic HuR expression was closely associated with the efficacy of AGC in patients with cholangiocarcinoma. The current findings warrant further investigations to optimize adjuvant chemotherapy regimens for resectable cholangiocarcinoma.

  16. John Paul College: The Professional Renewal Journey

    Directory of Open Access Journals (Sweden)

    Pauline Mundie

    2014-09-01

    Full Text Available John Paul College, a K-12 School in Queensland, Australia, recognises the centrality of classroom teachers to the ongoing improvement of student outcomes. The college has implemented a multi-tiered professional renewal and assessment process. These changes of emphasis are the result of significant research and subsequent/associated professional discussion and were supported during the EBA decision-making in 2012. The professional renewal process at John Paul College guides teachers through a cycle of goal setting (related to any aspect of teacher practice which aims to improve student learning and achievement; ongoing discussion between the teacher and a mentor which determines actions; directed classroom observations (3 per term and associated pre and post reflection/discussion; leading to application of changed practice toward achieving the criteria of the goals. The principles of the professional renewal program are to:  enhance development along accepted school-wide, team and department goals;  encourage professional pedagogical reflections and conversations with a colleague/mentor;  motivate improved performance and highlight the next steps in a teacher’s development. Through the introduction of professional renewal, attestation and exemplary teacher processes, the leadership and teachers of John Paul College have achieved an appropriate and innovative balance between self-directed, peer supported/directed and college-wide, strategic initiatives. Each member of the teaching team, from graduate to senior leaders are actively engaged in personalised programs of professional growth which is specifically aimed at improved learning and outcomes of the college’s students.

  17. Présentation de Paul Colonna

    OpenAIRE

    Corvol, Pierre

    2013-01-01

    Cher Collègue, Cher Paul Colonna, Il y a moins de vingt ans est apparue dans le monde une nouvelle chimie, la chimie verte. Cette chimie est une alternative à l’utilisation du carbone fossile et d’autres types d’énergie non renouvelables (gaz, charbon). La chimie traditionnelle à base de pétrole est certes performante, créative, compétitive, et répond bien à nos besoins, mais elle est aussi polluante et épuise les ressources de carbone fossile. La chimie verte se développe à côté de la chimie...

  18. Microfabricated linear Paul-Straubel ion trap

    Science.gov (United States)

    Mangan, Michael A [Albuquerque, NM; Blain, Matthew G [Albuquerque, NM; Tigges, Chris P [Albuquerque, NM; Linker, Kevin L [Albuquerque, NM

    2011-04-19

    An array of microfabricated linear Paul-Straubel ion traps can be used for mass spectrometric applications. Each ion trap comprises two parallel inner RF electrodes and two parallel outer DC control electrodes symmetric about a central trap axis and suspended over an opening in a substrate. Neighboring ion traps in the array can share a common outer DC control electrode. The ions confined transversely by an RF quadrupole electric field potential well on the ion trap axis. The array can trap a wide array of ions.

  19. Calibration Laboratory of the Paul Scherrer Institute

    International Nuclear Information System (INIS)

    Gmuer, K.; Wernli, C.

    1994-01-01

    Calibration and working checks of radiation protection instruments are carried out at the Calibration Laboratory of the Paul Scherrer Institute. In view of the new radiation protection regulation, the calibration laboratory received an official federal status. The accreditation procedure in cooperation with the Federal Office of Metrology enabled a critical review of the techniques and methods applied. Specifically, personal responsibilities, time intervals for recalibration of standard instruments, maximum permissible errors of verification, traceability and accuracy of the standard instruments, form and content of the certificates were defined, and the traceability of the standards and quality assurance were reconsidered. (orig.) [de

  20. HuPSON: the human physiology simulation ontology.

    Science.gov (United States)

    Gündel, Michaela; Younesi, Erfan; Malhotra, Ashutosh; Wang, Jiali; Li, Hui; Zhang, Bijun; de Bono, Bernard; Mevissen, Heinz-Theodor; Hofmann-Apitius, Martin

    2013-11-22

    Large biomedical simulation initiatives, such as the Virtual Physiological Human (VPH), are substantially dependent on controlled vocabularies to facilitate the exchange of information, of data and of models. Hindering these initiatives is a lack of a comprehensive ontology that covers the essential concepts of the simulation domain. We propose a first version of a newly constructed ontology, HuPSON, as a basis for shared semantics and interoperability of simulations, of models, of algorithms and of other resources in this domain. The ontology is based on the Basic Formal Ontology, and adheres to the MIREOT principles; the constructed ontology has been evaluated via structural features, competency questions and use case scenarios.The ontology is freely available at: http://www.scai.fraunhofer.de/en/business-research-areas/bioinformatics/downloads.html (owl files) and http://bishop.scai.fraunhofer.de/scaiview/ (browser). HuPSON provides a framework for a) annotating simulation experiments, b) retrieving relevant information that are required for modelling, c) enabling interoperability of algorithmic approaches used in biomedical simulation, d) comparing simulation results and e) linking knowledge-based approaches to simulation-based approaches. It is meant to foster a more rapid uptake of semantic technologies in the modelling and simulation domain, with particular focus on the VPH domain.

  1. Obscurity of poetry in Paul Celan

    Directory of Open Access Journals (Sweden)

    Mauricio Mendonça Cardozo

    2012-07-01

    Full Text Available Tensioned between variations of the said and the unsaid, and between figures of light and shadow, Paul Celan's work performs a certain confrontation with the condition of silence and obscurity, breaking all at once with a certain way of making poetry and of relating to reality. In this sense, Celan's work can hardly be reduced to a kind of hermeticism, a category too vague to account for its singularity. In his work saying and silencing together articulate the tension that creates the poetic space in which the poem is inscribed. The poet himself tried to refuse the insistence of some critics on labeling his work as obscure. Despite of its fragmentary nature, the recently published manuscripts of his speech project Von der Dunkelheit des Dichterischen constitutes one of Celan’s most extensive discussions of the matter of obscurity in poetry. This paper aims at presenting the fragments of his speech project and pointing out its importance to the discussion of the notion of obscurity in Paul Celan's work.

  2. Jean-Paul Diss (1928-2012)

    CERN Multimedia

    2012-01-01

    We were greatly saddened to learn of the sudden death of Dr Jean-Paul Diss at his home on 7 June 2012.   Jean-Paul studied medicine at the Strasbourg Faculty of Medicine and began his career as an occupational medical practitioner at the Mulhouse potash mines. He then came to CERN in 1965 to set up a Medical Service at the request of the then CERN Director-General, Professor Weisskopf. He was the first person to hold the position of Head of the Medical Service and he invested all his energies to provide the Organization with an occupational healthcare unit worthy of the name. As a pioneer of occupational medicine, he worked tirelessly to improve the working conditions of the members of the personnel and continued to be solicitous about the health of every member of the personnel until his retirement in 1993.  Over the past twenty years, he remained active within the CERN Pensioners Association, in particular as the pensioners’ representative on the CERN Health Insuran...

  3. SUPPORT FOR HU CFRT SUMMER HIGH SCHOOL FUSION WORKSHOP

    International Nuclear Information System (INIS)

    Punjabi, Alkesh

    2010-01-01

    Nine summer fusion science research workshops for minority and female high school students were conducted at the Hampton University Center for Fusion Research and Training from 1996 to 2005. Each workshop was of the duration of eight weeks. In all 35 high school students were mentored. The students presented 28 contributed papers at the annual meetings of the American Physical Society Division of Plasma Physics. These contributed papers were very well received by the plasma physics and fusion science research community. The students won a number of prestigious local, state, and national honors, awards, prizes, and scholarships. The notable among these are the two regional finalist positions in the 1999 Siemens-Westinghouse Science and Technology Competitions; 1st Place U.S. Army Award, 2006; 1st Place U.S. Naval Science Award, 2006; Yale Science and Engineering Association Best 11th Grade Project, 2006; Society of Physics Students Book Award, 2006; APS Corporate Minority Scholarship and others. This workshop program conducted by the HU CFRT has been an exemplary success, and served the minority and female students exceptionally fruitfully. The Summer High School Fusion Science Workshop is an immensely successful outreach activity conducted by the HU CFRT. In this workshop, we train, motivate, and provide high quality research experiences to young and talented high school scholars with emphasis on under-represented minorities and female students in fusion science and related areas. The purpose of this workshop is to expose minority and female students to the excitement of research in science at an early stage in their academic lives. It is our hope that this may lead the high school students to pursue higher education and careers in physical sciences, mathematics, and perhaps in fusion science. To our knowledge, this workshop is the first and only one to date, of fusion science for under-represented minorities and female high school students at an HBCU. The faculty

  4. Temperature dependence of HU values for various water equivalent phantom materials

    International Nuclear Information System (INIS)

    Homolka, P.; Nowotny, R.; Gahleitner, A.

    2002-01-01

    The temperature dependence of water equivalent phantom materials used in radiotherapy and diagnostic imaging has been investigated. Samples of phantom materials based on epoxy resin, polyethylene, a polystyrene-polypropylene mixture and commercially available phantom materials (Solid Water TM , Gammex RMI and Plastic Water TM , Nuclear Associates) were scanned at temperatures from 15 to 40 deg. C and HU values determined. At a reference temperature of 20 deg. C materials optimized for CT applications give HU values close to zero while the commercial materials show an offset of 119.77 HU (Plastic Water) and 27.69 HU (Solid Water). Temperature dependence was lowest for epoxy-based materials (EPX-W: -0.23 HU deg. C -1 ; Solid Water: -0.25 HU deg. C -1 ) and highest for a polyethylene-based material (X0: -0.72 HU deg. C -1 ). A material based on a mixture of polystyrene and polypropylene (PSPP1: -0.27 HU deg. C -1 ) is comparable to epoxy-based materials and water (-0.29 HU deg. C -1 ). (author)

  5. Reframing Paul's sibling language in light of Jewish epistolary forms ...

    African Journals Online (AJOL)

    However, Jewish dimensions (particularly ethnic dimensions) of Paul's sibling language still remain unexplored in current scholarship. Furthermore, scholars have not drawn much attention to how Jewish letter writers use sibling terms in their letters. This article offers a new interpretation on Paul's sibling language in light of ...

  6. Hermeneutics in identity formation: Paul's use of Genesis in ...

    African Journals Online (AJOL)

    Paul's hermeneutics, in dealing with the scriptures and traditions of Israel and his concern for a specific identity for the communities he interacted with, require attention for the reciprocal, interrelationship between hermeneutics and identity in his letters. Paul's quotations from and allusions to the scriptures of Israel but also ...

  7. C++ FOR PARTICLE PHYSICISTS By Paul Kunz

    CERN Document Server

    TECHNICAL TRAINING; Tel. 74460

    2001-01-01

    Please note that Paul Kunz will be giving his very popular and highly recommended C++ course again on March 5 to 9. The course costs 200 CHF, and advance registration is required. People with CERN EDH accounts can apply electronically directly from the Web course description page : http://www.cern.ch/Training/ENSTEC/P9798/Software/cpppp_e.htm Team Visitors should ask their Group Leader to send an e-mail to the DTO of EP Division, M. Burri, referring to the 'C++ for Particle Physicists' course and giving their name, CERN ID number, the Team account number to which the course fee should be charged, and VERY IMPORTANTLY an email address to which an invitation to the course can be sent.

  8. C++ FOR PARTICLE PHYSICISTS by Paul Kunz

    CERN Document Server

    Technical Training; Tel. 74460

    2001-01-01

    Please note that Paul Kunz will be giving his very popular and highly recommended C++ course again on March 5 to 9. The course costs 200 CHF, and advance registration is required. People with CERN EDH accounts can apply electronically directly from the Web course description page : http://www.cern.ch/Training/ENSTEC/P9798/Software/cpppp_e.htm Team Visitors should ask their Group Leader to send an e-mail to the DTO of EP Division, M. Burri, referring to the 'C++ for Particle Physicists' course and giving their name, CERN ID number, the Team account number to which the course fee should be charged, and VERY IMPORTANTLY an email address to which an invitation to the course can be sent.

  9. Paul Valery: Un canto de frontera

    Directory of Open Access Journals (Sweden)

    Eduardo Carranza

    1966-09-01

    Full Text Available Paul Valery nació en Cette el 30 de octubre de 1871, de padre francés y de madre italiana. Hizo sus primeros estudios en un colegio de su pequeña ciudad natal y realizó luego con sus padres un viaje infantil a París y a Londres. En 1884 siguió los cursos del Colegio de Montpellier. Pasaba sus vacaciones en Génova con los suyos, circunstancia que incorporó a su espíritu una estela de reminiscencias italianas. Siguió luego cursos en la Facultad de Derecho y, ya en el umbral de la primera juventud, vacilaba ante la escogencia de su destino.

  10. Paul B. Pedersen (1936-2017).

    Science.gov (United States)

    Lonner, Walter J; Draguns, Juris G

    2018-01-01

    Presents an obituary for Paul B. Pedersen, who passed away on January 11, 2017, in a Minnetonka, Minnesota hospital. In 1973 Pedersen convened a pathfinding APA (Division 9) symposium in Montreal that resulted in the publication in 1976 of Counseling Across Cultures (Pedersen, Lonner, and Draguns, Eds.). The first book of its kind, it became the "Granddaddy" of all subsequent books in that area. The seventh edition, published in 2016 (with Trimble and Scharron-del Rio, co-eds), benefitted from his steadfast encouragement, but his deteriorating health prevented a more active role. His epitaph may well be one of his wisest and oft-quoted sayings: "All interviewing and counseling is multicultural. Each client comes to the session embodying multiple voices from the past." (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  11. Research at the Paul Scherrer Institut

    International Nuclear Information System (INIS)

    Walter, H.K.

    1996-01-01

    The Paul Scherrer Institut (PSI) is a multidisciplinary research institute for natural sciences and technology. In national and international collaboration with universities, other research institutes and industry, PSI is active in elementary particle physics, life sciences, solid-state physics, material sciences, nuclear and non-nuclear energy research, and energy-related ecology. PSI's priorities lie in research fields which are relevant to sustainable development, serve educational needs and are beyond the possibilities of a single university department. PSI develops and operates complex research installations open of the world's most powerful cyclotron, allowing to operate high intensity secondary pion and muon beams, a neutron spallation source and various applications in medicine and materials research. A short review on research at PSI is presented, with special concentration on particle physics experiments. (author)

  12. HU deviation in lung and bone tissues: Characterization and a corrective strategy.

    Science.gov (United States)

    Ai, Hua A; Meier, Joseph G; Wendt, Richard E

    2018-05-01

    In the era of precision medicine, quantitative applications of x-ray Computed Tomography (CT) are on the rise. These require accurate measurement of the CT number, also known as the Hounsfield Unit. In this study, we evaluated the effect of patient attenuation-induced beam hardening of the x-ray spectrum on the accuracy of the HU values and a strategy to correct for the resulting deviations in the measured HU values. A CIRS electron density phantom was scanned on a Siemens Biograph mCT Flow CT scanner and a GE Discovery 710 CT scanner using standard techniques that are employed in the clinic to assess the HU deviation caused by beam hardening in different tissue types. In addition, an anthropomorphic ATOM adult male upper torso phantom was scanned on the GE Discovery 710 scanner. Various amounts of Superflab bolus material were wrapped around the phantoms to simulate different patient sizes. The mean HU values that were measured in the phantoms were evaluated as a function of the water-equivalent area (A w ), a parameter that is described in the report of AAPM Task Group 220. A strategy by which to correct the HU values was developed and tested. The variation in the HU values in the anthropomorphic ATOM phantom under different simulated body sizes, both before and after correction, were compared, with a focus on the lung and bone tissues. Significant HU deviations that depended on the simulated patient size were observed. A positive correlation between HU and A w was observed for tissue types that have an HU of less than zero, while a negative correlation was observed for tissue types with HU values that are greater than zero. The magnitude of the difference increases as the underlying attenuation property deviates further away from that of water. In the electron density phantom study, the maximum observed HU differences between the measured and reference values in the cortical bone and lung materials were 426 and 94 HU, respectively. In the anthropomorphic phantom

  13. [Heinz von zur Mühlen. Paul Johansen und die Sogenannten Undeutschen in Reval/Tallinn] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2008-01-01

    Arvustus: Heinz von zur Mühlen. Paul Johansen und die Sogenannten Undeutschen in Reval/Tallinn. - Nordosteuropa als Geschichtsregion. Helsinki : Aue-Stiftung :; Lübeck : Schmidt-Römhild, 2006. lk. 103-111. Paul Johanseni lähim töökaaslane kirjeldab teose "Deutsch und Undeutsch im mittelalterlichen und frühneuzeitlichen Reval" valmimist

  14. HuD Regulates Coding and Noncoding RNA to Induce APP→Aβ Processing

    Directory of Open Access Journals (Sweden)

    Min-Ju Kang

    2014-06-01

    Full Text Available The primarily neuronal RNA-binding protein HuD is implicated in learning and memory. Here, we report the identification of several HuD target transcripts linked to Alzheimer’s disease (AD pathogenesis. HuD interacted with the 3′ UTRs of APP mRNA (encoding amyloid precursor protein and BACE1 mRNA (encoding β-site APP-cleaving enzyme 1 and increased the half-lives of these mRNAs. HuD also associated with and stabilized the long noncoding (lncRNA BACE1AS, which partly complements BACE1 mRNA and enhances BACE1 expression. Consistent with HuD promoting production of APP and APP-cleaving enzyme, the levels of APP, BACE1, BACE1AS, and Aβ were higher in the brain of HuD-overexpressing mice. Importantly, cortex (superior temporal gyrus from patients with AD displayed significantly higher levels of HuD and, accordingly, elevated APP, BACE1, BACE1AS, and Aβ than did cortical tissue from healthy age-matched individuals. We propose that HuD jointly promotes the production of APP and the cleavage of its amyloidogenic fragment, Aβ.

  15. Magnetohydrodynamics and the earth's core selected works by Paul Roberts

    CERN Document Server

    Soward, Andrew M

    2003-01-01

    Paul Roberts'' research contributions are remarkable in their diversity, depth and international appeal. Papers from the Paul Roberts'' Anniversary meeting at the University of Exeter are presented in this volume. Topics include geomagnetism and dynamos, fluid mechanics and MHD, superfluidity, mixed phase regions, mean field electrodynamics and the Earth''s inner core. An incisive commentary of the papers puts the work of Paul Roberts into historical context. Magnetohydrodynamics and the Earth''s Core provides a valuable source of reference for graduates and researchers working in this area of geoscience.

  16. Paul Dirac: the purest soul in physics

    International Nuclear Information System (INIS)

    Berry, M.

    1998-01-01

    Paul Dirac published the first of his papers on ''The Quantum Theory of the Electron'' seventy years ago this month. Published in the Proceedings of the Royal Society (London) in February and March 1928, the papers contained one of the greatest leaps of imagination in 20th century physics. The Dirac equation, derived in those papers, is one of the most important equations in physics. Dirac showed that the simplest wave satisfying the requirements of quantum mechanics and relativity was not a simple number but had four components. He found that the logic that led to the theory was, although deeply sophisticated, in a sense beautifully simple. Much later, when someone asked him ''How did you find the Dirac equation?'' he is said to have replied: ''I found it beautiful''. In addition to explaining the magnetic and spin properties of the electron, the equation also predicts the existence of antimatter. Because Dirac was a quiet man - famously quiet, indeed - he is not well known outside physics, although this is slowly changing. In 1995 a plaque to Dirac was unveiled at Westminster Abbey in London and last year Institute of Physics Publishing, which is based in Bristol, named its new building Dirac House. In this article the author recalls the achievements of the greatest physicists of the 20th century. (UK)

  17. Open letter to Pope John Paul II.

    Science.gov (United States)

    Sai, F

    1991-01-01

    In an Open Letter to Pope John Paul II, written on World Population Day (July 11) 1991, Dr. Fred Sai, President of International Planned Parenthood Federation (IPPF), called for a dialogue on voluntary family planning as a means of avoiding unwanted pregnancy. A half million women die each year from pregnancy-related causes--a death toll that could be dramatically reduced by universal access to low cost, effective contraception. Family planning further represents the best protection against abortion. The Catholic Church's vehement opposition to abortion and family planning methods other than periodic abstinence is in marked contrast to its support to human rights in other settings. The Church has supported struggles for economic ju stice in and among nations, sided with the poor, and advocated for transitions to democracy. At the same time, the family planning movement--which has as its overall objective the protection of the health and welfare of women, children, and families--is viewed by the Vatican as a vehicle for the enslavement rather than liberation of women. The opening of a sensitive dialogue between the Catholic Church and supporters of voluntary family planning could help couples make sound moral decisions about their families and contribute to saving the lives of millions of women, most of them poor.

  18. Paul Ehrenfest and the dilemmas of modernity.

    Science.gov (United States)

    van Lunteren, Frans H; Hollestelle, Marijn J

    2013-09-01

    This essay considers the highly ambivalent attitude of the Austrian-Dutch physicist Paul Ehrenfest toward contemporary developments in both science and society. On the one hand, he was in the vanguard of the quantum and relativity revolutions, supported industrialization and economic planning based on mathematical models, and, in general, cherished technocratic ideals. The essay highlights several influences that shaped his attitude in these respects, from his ties with the Philips Physics Laboratory and his sojourns in the United States to the utopian visions of H. G. Wells. On the other hand, he was extremely worried about the harmful consequences of contemporary changes in science and society, such as specialization, the growing pace of city life, and the increasing dependence on modern technologies, be they material or mathematical. In this regard, he agreed with cultural critics such as Max Nordau, Henri Bergson, Ostwald Spengler, and Ludwig Klages. Rather than attempting to solve this paradox, the essay suggests that this kind of ambiguity characterized a great deal of innovative science in the period.

  19. Sumbangan Paul Ricoeur dalam Proses Berteologi

    Directory of Open Access Journals (Sweden)

    John Christianto Simon

    2018-04-01

    Full Text Available In understanding the theologizing process, the foci are not only on the reality, but also on the means or tools to understand the reality. This article intends to explain the means or tools of theologizing process according to Paul Ricoeur. As a process what at stake is not only the method, but also the methodology, namely the thinking process, the interest of the subject and the premises on certain values. The guiding question is what is Ricoeur’s theologizing methodology, i.e. his hermeneutics? Through dialogue with many parties, Ricoeur found the methodology of reading reality is started with an affi rmation and ended with a critic toward the distortion of reality; this is an affirmative-critical position. However, this methodology is inadequate to comprehend an extremely distorted reality. Hence, the present article offers a reversal move of theologizing process, by prioritizing the critical position toward the distorted reality and following up with the affirmation process by uncovering the element of hope of a good and just life. Ultimately, the theologizing process requires a dialectical methodology of reading the reality, between the critical-affirmative and affirmative-critical positions. The priority of the option is determined by the contextual challenges at hand.

  20. Feasibility Report. Mississippi River at Saint Paul, Minnesota. Reevaluation of Saint Paul Flood Control Project.

    Science.gov (United States)

    1981-09-01

    formal consultation process should be initiated. This should be done by writing to the Regional Director, U. S. Fish and Wildlife Service, Federal...16 5 FC.F PIPFRiF G;~IPHFiTIOtl LAYEP THIi>.NE*:7. 12. Ilit HES’ PERCENT LI’THTEP LIfIIT:- OFTfE B:Y WJEIGHT (JE,: I GHT LI. 15 12 wRITE FUAJLT- OIF...Paul to 8 inches in the headwaters. Cold weather nearly halted snow ielt runoff during the latter part of March, allowing many streams to drop below

  1. XXI sajandi kontuurid / Paul Johnson ; refereerinud Mihkel Mutt

    Index Scriptorium Estoniae

    Johnson, Paul

    1997-01-01

    Washingtonis 14.-16. juunini peetud 'Lääne kirjanduse konverentsil' pidas põhiettekande ameerika ajaloolane ja publitsist Paul Johnson. Refereering tema 'XXI sajandi geopoliitiliste ja kultuuriliste väljavaadete' seisukohtadest

  2. Meet EPA Ecologist Paul Mayer, Ph.D.

    Science.gov (United States)

    EPA ecologist Paul Mayer, Ph.D. works in EPA's Groundwater and Ecosystem Restoration division where he studies riparian zones (the area along rivers and streams where the habitats are influenced by both the land and water) and stream restoration

  3. Hermeneutics in identity formation: Paul's use of Genesis in ...

    African Journals Online (AJOL)

    Test

    2010-08-06

    Aug 6, 2010 ... psychological functioning and large-scale social processes .... the Christian's life of service to God as a spiritual battle; however, military terms dominate .... subscribes to Dunn's thesis that Paul's law-polemic addressed Jewish ...

  4. Science in culture the life of Paul Dirac

    CERN Multimedia

    Abbott, A

    2000-01-01

    The life of Paul Dirac has been used as the theme of a show held underground at the Delphi experiment at CERN. The 'Oracle of Delphi' was created as an outreach project and has been extremely successful (1 p).

  5. Revised Mulliken Electronegativities I. Calculation and Conversion to Pauling Units.

    Science.gov (United States)

    Bratsch, Steven G.

    1988-01-01

    Discusses a revision and extension of the Mulliken electronegativity scale to consider 50 elements. Describes the calculation of valence-state promotion energies and Mulliken atomic electronegativities and the conversion of Mulliken electronegativities to Pauling units. (CW)

  6. Measurement of hard tissue density of head phantom based on the HU by using CBCT

    International Nuclear Information System (INIS)

    Kim, Moon Sun; Kang, Dong Wan; Kim, Jae Duk

    2009-01-01

    The purpose of this study was to determine a conversion coefficient for Hounsfield Units(HU) to material density (g cm -3 ) obtained from cone-beam computed tomography (CBMercuRay TM ) data and to measure the hard tissue density based on the Hounsfield scale on dental head phantom. CT Scanner Phantom (AAPM) equipped with CT Number Insert consists of five cylindrical pins of materials with different densities and teflon ring was scanned by using the CBMercuRay TM (Hitachi, Tokyo, Japan) volume scanner. The raw data were converted into DICOM format and the HU of different areas of CT number insert measured by using CBWorks TM . Linear regression analysis and Student t-test were performed statistically. There was no significant difference (P>0.54) between real densities and measured densities. A linear regression was performed using the density, ρ (g cm -3 ), as the dependent variable in terms of the HU (H). The regression equation obtained was ρ=0.00072 H-0.01588 with an R2 value of 0.9968. Density values based on the Hounsfield scale was 1697.1 ± 24.9 HU in cortical bone, 526.5 ± 44.4 HU in trabecular bone, 2639.1 ± 48.7 HU in enamel, 1246.1 ± 39.4 HU in dentin of dental head phantom. CBCT provides an effective option for determination of material density expressed as Hounsfield Units.

  7. Nanosystems based on siRNA silencing HuR expression counteract diabetic retinopathy in rat.

    Science.gov (United States)

    Amadio, Marialaura; Pascale, Alessia; Cupri, Sarha; Pignatello, Rosario; Osera, Cecilia; D Agata, Velia; D Amico, Agata Grazia; Leggio, Gian Marco; Ruozi, Barbara; Govoni, Stefano; Drago, Filippo; Bucolo, Claudio

    2016-09-01

    We evaluated whether specifically and directly targeting human antigen R (HuR), a member of embryonic lethal abnormal vision (ELAV) proteins family, may represent a new potential therapeutic strategy to manage diabetic retinopathy. Nanosystems loaded with siRNA silencing HuR expression (lipoplexes), consisting of solid lipid nanoparticles (SLN) and liposomes (SUV) were prepared. Photon correlation spectroscopy analysis, Zeta potential measurement and atomic force microscopy (AFM) studies were carried out to characterize the complexation of siRNA with the lipid nanocarriers. Nanosystems were evaluated by using AFM and scanning electron microscopy. The lipoplexes were injected into the eye of streptozotocin (STZ)-induced diabetic rats. Retinal HuR and VEGF levels were detected by Western blot and ELISA, respectively. Retinal histology was also carried out. The results demonstrated that retinal HuR and VEGF are significantly increased in STZ-rats and are blunted by HuR siRNA treatment. Lipoplexes with a weak positive surface charge and with a 4:1 N/P (cationic lipid nitrogen to siRNA phosphate) ratio exert a better transfection efficiency, significantly dumping retinal HuR and VEGF levels. In conclusion, we demonstrated that siRNA can be efficiently delivered into the rat retina using lipid-based nanocarriers, and some of the lipoplexes loaded with siRNA silencing HuR expression are potential candidates to manage retinal diseases. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Occurrence of chai hu (Bupleuri radix) in prescriptions of Chinese herbal medicine in Switzerland.

    Science.gov (United States)

    Klein, Sabine D; Becker, Simon; Wolf, Ursula

    2012-01-01

    Chai hu (Bupleuri radix), one of the most frequently used herbs in Chinese herbal medicine, has 3 major functions, depending on dosage and combination with other herbs. The aim of this study was to investigate how chai hu is prescribed in everyday practice in Switzerland, and whether these prescription patterns reflect its various applications. A random sample of 1,053 prescriptions was drawn from the database of Lian Chinaherb AG, Wollerau, Switzerland, and analyzed regarding the most frequently used classical formulas containing chai hu, daily dosages and combinations with other herbs. 29.0% of all prescriptions contained chai hu, and 98.0% of these were in granular form. The most frequently used classical formulas were xiao yao san ('rambling powder'), jia wei xiao yao san ('augmented rambling powder') and chai hu shu gan san ('Bupleurum powder to spread the liver'). In more than half of the prescriptions, chai hu was combined with bai shao (Paeoniae Radix Alba), dang gui (Angelicae sinensis radix) or fu ling (Poria). 51.8% of the prescriptions contained a low daily dosage of chai hu, 24.9% a medium and 15.1% a high dosage. Chai hu was generally prescribed in classic combinations with other herbs and in a medium dosage. Due to the addition of supplementary herbs to classical formulas, its daily dose was often diminished from a high or medium dose to a low dose. This raises the question if chai hu would then still exert its desired function of, e.g., moving liver-qi in these prescriptions.

  9. Paul Krugman: välisvaluuta külge klammerdumine pole jätkusuutlik / Paul Krugman

    Index Scriptorium Estoniae

    Krugman, Paul, 1953-

    2009-01-01

    Valik 2008. aasta Nobeli majanduspreemia laureaadi Paul Krugmani vastuseid New Yorgi välisajakirjanike pressikeskuse briifingul "Kas depressioonimajandus tuleb tagasi?" esitatud Slovakkia, Lõuna-Aafrika, Austraalia ja Austria ajakirjanike küsimustele

  10. Metabolic aspects of growth in HU-treated crown-gall tissue cultures. II. Helianthus annuus

    Directory of Open Access Journals (Sweden)

    Aldona Rennert

    2015-01-01

    Full Text Available The dynamics of growth and changes in nucleic acid and protein contents in sunflower calluses and tumours cultured in hydroxyurea (HU containing media were examined. HU-induced changes in healthy tissues ran in parallel always in the same direction, in tumourous ones however an uncoupling between DNA synthesis and tissue growth on one hand and RNA and protein synthesis on the other took place. A detailed analysis of the results allows to suppose that the specific activity of HU on tumourous tissue could be an index of: 1 quantitative disturbances in its genes function (2 degree of the lass of sensitivity to the factors of regulation.

  11. Blocking Breast Cancer Metastasis by Targeting RNA-Binding Protein HuR

    Science.gov (United States)

    2017-10-01

    AWARD NUMBER: W81XWH-16-1-0730 TITLE: Blocking Breast Cancer Metastasis by Targeting RNA-Binding Protein HuR PRINCIPAL INVESTIGATOR: Danny Welch...NUMBER Blocking Breast Cancer Metastasis by Targeting RNA-Binding Protein HuR 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...increased aggressiveness in breast cancer , the primary objective of this proposal is to assess whether HuR (or analogs) prevent and/or treat metastasis and/or

  12. Paul Krugman : (presque un Nobel de géographie Paul Krugman: A Nobel Prize in geography?

    Directory of Open Access Journals (Sweden)

    Olivier Walther

    2011-09-01

    Full Text Available Paul Krugman a reçu le Prix Nobel d’économie pour son analyse des modèles du commerce mondial et de la localisation de l’activité économique. Voilà une nouvelle qui devrait réjouir certains géographes.Paul Krugman recently won Nobel Economics Prize for his work on trade patterns and location of economic activities. This sounds like good news for (some geographers.

  13. Hmong Political Involvement in St. Paul, Minnesota and Fresno, California

    Directory of Open Access Journals (Sweden)

    Yang Lor

    2010-01-01

    Full Text Available Over the past several years, Hmong in the United States have gained prominence for their increasing involvement in politics. Most of the attention has understandably focused on Fresno, California and St. Paul, Minnesota, home to the two largest Hmong populations in this country. While the Hmong communities in both cities are similar in size and have made significant political progress as evidenced by the election of Hmong candidates, the Hmong community in St. Paul has made greater inroads in the political realm. In addition to the elections of two Hmong candidates to the Minnesota State Legislature and two to the St. Paul School Board, the Hmong community in St. Paul has been able to engage local and state governments in Minnesotato address issues that affect the Hmong community. Through interviews, census data, and newspaper coverage of political campaigns, I show that Hmong in St. Paul have achieved greaterrepresentation in local and state governments and received greater support from government officials than Hmong in Fresno because Minnesota offers a social, economic, and politicalcontext that is favorable to fostering Hmong political involvement. Compared to Hmong in Fresno, Hmong in St. Paul have higher levels of socioeconomic resources and are more visible given their large size relative to other minority groups. They live in a region with consistently high levels of political participation and have political candidates who devote resources to mobilizing the Hmong community. Moreover, the Hmong vote has been critical to the success of Hmong candidates in St. Paul, an indication of the increasing political clout of the Hmong community there and a major reason why politicians in Minnesota are more willing to respond toissues that affect the Hmong community. Overall, this study highlights the importance of local and regional context in understanding the political incorporation of immigrants.

  14. High quality draft genome sequence of Staphylococcus cohnii subsp. cohnii strain hu-01

    OpenAIRE

    Hu, XinJun; Li, Ang; Lv, LongXian; Yuan, Chunhui; Guo, Lihua; Jiang, Xiawei; Jiang, Haiyin; Qian, GuiRong; Zheng, BeiWen; Guo, Jing; Li, LanJuan

    2014-01-01

    Staphylococcus cohnii subsp. cohnii belongs to the family Staphylococcaceae in the order Bacillales , class Bacilli and phylum Firmicutes . The increasing relevance of S. cohnii to human health prompted us to determine the genomic sequence of Staphylococcus cohnii subsp. cohnii strain hu-01, a multidrug-resistant isolate from a hospital in China. Here we describe the features of S. cohnii subsp. cohnii strain hu-01, together with the genome sequence and its annotation. This is the first genom...

  15. Zebrafish transgenic line huORFZ is an effective living bioindicator for detecting environmental toxicants.

    Directory of Open Access Journals (Sweden)

    Hung-Chieh Lee

    Full Text Available Reliable animal models are invaluable for monitoring the extent of pollution in the aquatic environment. In this study, we demonstrated the potential of huORFZ, a novel transgenic zebrafish line that harbors a human upstream open reading frame of the chop gene fused with GFP reporter, as an animal model for monitoring environmental pollutants and stress-related cellular processes. When huORFZ embryos were kept under normal condition, no leaked GFP signal could be detected. When treated with hazardous chemicals, including heavy metals and endocrine-disrupting chemicals near their sublethal concentrations (LC50, huORFZ embryos exhibited different tissue-specific GFP expression patterns. For further analysis, copper (Cu2+, cadmium (Cd2+ and Chlorpyrifos were applied. Cu2+ triggered GFP responses in skin and muscle, whereas Cd2+ treatment triggered GFP responses in skin, olfactory epithelium and pronephric ducts. Moreover, fluorescence intensity, as exhibited by huORFZ embryos, was dose-dependent. After surviving treated embryos were returned to normal condition, survival rates, as well as TUNEL signals, returned to pretreatment levels with no significant morphological defects observed. Such results indicated the reversibility of treatment conditions used in this study, as long as embryos survived such conditions. Notably, GFP signals decreased along with recovery, suggesting that GFP signaling of huORFZ embryos likely reflected the overall physiological condition of the individual. To examine the performance of the huORFZ line under real-world conditions, we placed huORFZ embryos in different river water samples. We found that the huORFZ embryos correctly detected the presence of various kinds of pollutants. Based on these findings, we concluded that such uORFchop-based system can be integrated into a first-line water alarm system monitoring the discharge of hazardous pollutants.

  16. Zebrafish Transgenic Line huORFZ Is an Effective Living Bioindicator for Detecting Environmental Toxicants

    Science.gov (United States)

    Chu, Chien; Li, Hong-Ping; Tsai, Huai-Jen

    2014-01-01

    Reliable animal models are invaluable for monitoring the extent of pollution in the aquatic environment. In this study, we demonstrated the potential of huORFZ, a novel transgenic zebrafish line that harbors a human upstream open reading frame of the chop gene fused with GFP reporter, as an animal model for monitoring environmental pollutants and stress-related cellular processes. When huORFZ embryos were kept under normal condition, no leaked GFP signal could be detected. When treated with hazardous chemicals, including heavy metals and endocrine-disrupting chemicals near their sublethal concentrations (LC50), huORFZ embryos exhibited different tissue-specific GFP expression patterns. For further analysis, copper (Cu2+), cadmium (Cd2+) and Chlorpyrifos were applied. Cu2+ triggered GFP responses in skin and muscle, whereas Cd2+ treatment triggered GFP responses in skin, olfactory epithelium and pronephric ducts. Moreover, fluorescence intensity, as exhibited by huORFZ embryos, was dose-dependent. After surviving treated embryos were returned to normal condition, survival rates, as well as TUNEL signals, returned to pretreatment levels with no significant morphological defects observed. Such results indicated the reversibility of treatment conditions used in this study, as long as embryos survived such conditions. Notably, GFP signals decreased along with recovery, suggesting that GFP signaling of huORFZ embryos likely reflected the overall physiological condition of the individual. To examine the performance of the huORFZ line under real-world conditions, we placed huORFZ embryos in different river water samples. We found that the huORFZ embryos correctly detected the presence of various kinds of pollutants. Based on these findings, we concluded that such uORFchop-based system can be integrated into a first-line water alarm system monitoring the discharge of hazardous pollutants. PMID:24594581

  17. dNTP deficiency induced by HU via inhibiting ribonucleotide reductase affects neural tube development

    International Nuclear Information System (INIS)

    Guan, Zhen; Wang, Xiuwei; Dong, Yanting; Xu, Lin; Zhu, Zhiqiang; Wang, Jianhua; Zhang, Ting; Niu, Bo

    2015-01-01

    Highlights: • Murine NTDs were successfully induced by means of hydroxyurea (HU). • The impairment of dNTP was induced via inhibition of ribonucleotide reductase. • dNTP deficiency induced by HU caused defective DNA synthesis and repair. • Abnormal apoptosis and proliferation induced by HU affected neural tube development. - Abstract: Exposure to environmental toxic chemicals in utero during the neural tube development period can cause developmental disorders. To evaluate the disruption of neural tube development programming, the murine neural tube defects (NTDs) model was induced by interrupting folate metabolism using methotrexate in our previous study. The present study aimed to examine the effects of dNTP deficiency induced by hydroxyurea (HU), a specific ribonucleotide reductase (RNR) inhibitor, during murine neural tube development. Pregnant C57BL/6J mice were intraperitoneally injected with various doses of HU on gestation day (GD) 7.5, and the embryos were checked on GD 11.5. RNR activity and deoxynucleoside triphosphate (dNTP) levels were measured in the optimal dose. Additionally, DNA damage was examined by comet analysis and terminal deoxynucleotidyl transferase mediated dUTP nick end-labeling (TUNEL) assay. Cellular behaviors in NTDs embryos were evaluated with phosphorylation of histone H3 (PH-3) and caspase-3 using immunohistochemistry and western blot analysis. The results showed that NTDs were observed mostly with HU treatment at an optimal dose of 225 mg/kg b/w. RNR activity was inhibited and dNTP levels were decreased in HU-treated embryos with NTDs. Additionally, increased DNA damage, decreased proliferation, and increased caspase-3 were significant in NTDs embryos compared to the controls. Results indicated that HU induced murine NTDs model by disturbing dNTP metabolism and further led to the abnormal cell balance between proliferation and apoptosis

  18. Different modes of interaction by TIAR and HuR with target RNA and DNA.

    Science.gov (United States)

    Kim, Henry S; Wilce, Matthew C J; Yoga, Yano M K; Pendini, Nicole R; Gunzburg, Menachem J; Cowieson, Nathan P; Wilson, Gerald M; Williams, Bryan R G; Gorospe, Myriam; Wilce, Jacqueline A

    2011-02-01

    TIAR and HuR are mRNA-binding proteins that play important roles in the regulation of translation. They both possess three RNA recognition motifs (RRMs) and bind to AU-rich elements (AREs), with seemingly overlapping specificity. Here we show using SPR that TIAR and HuR bind to both U-rich and AU-rich RNA in the nanomolar range, with higher overall affinity for U-rich RNA. However, the higher affinity for U-rich sequences is mainly due to faster association with U-rich RNA, which we propose is a reflection of the higher probability of association. Differences between TIAR and HuR are observed in their modes of binding to RNA. TIAR is able to bind deoxy-oligonucleotides with nanomolar affinity, whereas HuR affinity is reduced to a micromolar level. Studies with U-rich DNA reveal that TIAR binding depends less on the 2'-hydroxyl group of RNA than HuR binding. Finally we show that SAXS data, recorded for the first two domains of TIAR in complex with RNA, are more consistent with a flexible, elongated shape and not the compact shape that the first two domains of Hu proteins adopt upon binding to RNA. We thus propose that these triple-RRM proteins, which compete for the same binding sites in cells, interact with their targets in fundamentally different ways.

  19. Obituary: Damon Paul Simonelli, 1959-2004

    Science.gov (United States)

    Buratti, Bonnie Jean; Veverka, Joseph

    2005-12-01

    Damon Paul Simonelli died unexpectedly on 1 December 2004 after he collapsed of heart failure at his home near Pasadena, California. Damon led pioneering studies in the scientific exploration of the satellites of the Solar System with spacecraft. He was a longtime member of the AAS's Division for Planetary Sciences community. Only two weeks before his death he attended the 2004 DPS meeting in Louisville where he presented a paper on the surface roughness of Phoebe based on Cassini observations. Damon was born in the Bronx, New York, on 15 August 1959. His father, Aldo Simonelli (d. 1990), was a clarinetist for the New York City Opera Company, and his mother, Alice Kennard Simonelli, was a secretary. His parents met while they were both students at the Julliard School. Family history has it that Damon's mother was an opera student, but she ruined her voice after singing when she had the flu. By junior high school, Damon had become a master at convincing his mother to wake him up at 3 AM to watch televised moonwalks, and to allow the entire family to view Star Trek episodes at the dinner table. Damon graduated from the Bronx High School of Science in 1976, with a composition on the New York State Regents exam that mentioned the significance of bicentennial toilet bowl lids. In addition to placing great emphasis on humor, the Simonelli family valued education. Damon's younger sister Danelle graduated from Vassar College and has served many years as a U. S. Park Ranger at Liberty Island. Damon graduated with a BA summa cum laude in physics from Cornell in 1980, where he had begun working with Carl Sagan. Damon had painstakingly gone through all the Viking images to look for any possibility of sentient life on Mars (he didn't find any). Perhaps the arrival of data from the first great explorers of the outer Solar System - Voyagers 1 and 2 - convinced Damon to continue at Cornell with Joe Veverka. While at Cornell, Damon began his pioneering work on the use of

  20. Investigation of two-frequency Paul traps for antihydrogen production

    Energy Technology Data Exchange (ETDEWEB)

    Leefer, Nathan; Krimmel, Kai, E-mail: kkrimmel@students.uni-mainz.de [Helmholtz-Institut Mainz (Germany); Bertsche, William [University of Manchester (United Kingdom); Budker, Dmitry [Helmholtz-Institut Mainz (Germany); Fajans, Joel [University of California at Berkeley, Department of Physics (United States); Folman, Ron [Ben-Gurion University of the Negev, Department of Physics (Israel); Häffner, Hartmut [University of California at Berkeley, Department of Physics (United States); Schmidt-Kaler, Ferdinand [Helmholtz-Institut Mainz (Germany)

    2017-11-15

    Radio-frequency (rf) Paul traps operated with multifrequency rf trapping potentials provide the ability to independently confine charged particle species with widely different charge-to-mass ratios. In particular, these traps may find use in the field of antihydrogen recombination, allowing antiproton and positron clouds to be trapped and confined in the same volume without the use of large superconducting magnets. We explore the stability regions of two-frequency Paul traps and perform numerical simulations of small samples of multispecies charged-particle mixtures of up to twelve particles that indicate the promise of these traps for antihydrogen recombination.

  1. The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats.

    Science.gov (United States)

    Robinson, L; Goonawardena, A V; Pertwee, R G; Hampson, R E; Riedel, G

    2007-07-01

    Previous work implied that the hippocampal cannabinoid system was particularly important in some forms of learning, but direct evidence for this hypothesis is scarce. We therefore assessed the effects of the synthetic cannabinoid HU210 on memory and hippocampal activity. HU210 (100 microg kg(-1)) was administered intraperitoneally to rats under three experimental conditions. One group of animals were pre-trained in spatial working memory using a delayed-matching-to-position task and effects of HU210 were assessed in a within-subject design. In another, rats were injected before acquisition learning of a spatial reference memory task with constant platform location. Finally, a separate group of animals was implanted with electrode bundles in CA1 and CA3 and single unit responses were isolated, before and after HU210 treatment. HU210 treatment had no effect on working or short-term memory. Relative to its control Tween 80, deficits in acquisition of a reference memory version of the water maze were obtained, along with drug-related effects on anxiety, motor activity and spatial learning. Deficits were not reversed by the CB(1) receptor antagonists SR141716A (3 mg kg(-1)) or AM281 (1.5 mg kg(-1)). Single unit recordings from principal neurons in hippocampal CA3 and CA1 confirmed HU210-induced attenuation of the overall firing activity lowering both the number of complex spikes fired and the occurrence of bursts. These data provide the first direct evidence that the underlying mechanism for the spatial memory deficits induced by HU210 in rats is the accompanying abnormality in hippocampal cell firing.

  2. HuR represses Wnt/β-catenin-mediated transcriptional activity by promoting cytoplasmic localization of β-catenin

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Inae; Hur, Jung; Jeong, Sunjoo, E-mail: sjsj@dankook.ac.kr

    2015-01-30

    Highlights: • Wnt signaling as well as β-catenin overexpression enhance HuR cytoplasmic export. • HuR overexpression promotes cytoplasmic localization of β-catenin from the perinuclear fraction. • Wnt/β-catenin-mediated transcriptional activity is repressesed by HuR. - Abstract: β-Catenin is the key transcriptional activator of canonical Wnt signaling in the nucleus; thus, nuclear accumulation of β-catenin is a critical step for expressing target genes. β-Catenin accumulates in the nucleus of cancer cells where it activates oncogenic target genes. Hu antigen R (HuR) is a RNA binding protein that regulates multiple post-transcriptional processes including RNA stability. Thus, cytoplasmic HuR protein may be involved in tumorigenesis by stabilizing oncogenic transcripts, but the molecular mechanism remains unclear. Here, we observed that Wnt/β-catenin signaling induced export of the HuR protein, whereas HuR overexpression promoted accumulation of the β-catenin protein in the cytoplasm. Thus, Wnt/β-catenin-mediated transcriptional activity in the nucleus was reduced by overexpressing HuR. These results suggest novel and uncharacterized cytoplasmic β-catenin functions related to HuR-mediated RNA metabolism in cancer cells.

  3. HuR represses Wnt/β-catenin-mediated transcriptional activity by promoting cytoplasmic localization of β-catenin

    International Nuclear Information System (INIS)

    Kim, Inae; Hur, Jung; Jeong, Sunjoo

    2015-01-01

    Highlights: • Wnt signaling as well as β-catenin overexpression enhance HuR cytoplasmic export. • HuR overexpression promotes cytoplasmic localization of β-catenin from the perinuclear fraction. • Wnt/β-catenin-mediated transcriptional activity is repressesed by HuR. - Abstract: β-Catenin is the key transcriptional activator of canonical Wnt signaling in the nucleus; thus, nuclear accumulation of β-catenin is a critical step for expressing target genes. β-Catenin accumulates in the nucleus of cancer cells where it activates oncogenic target genes. Hu antigen R (HuR) is a RNA binding protein that regulates multiple post-transcriptional processes including RNA stability. Thus, cytoplasmic HuR protein may be involved in tumorigenesis by stabilizing oncogenic transcripts, but the molecular mechanism remains unclear. Here, we observed that Wnt/β-catenin signaling induced export of the HuR protein, whereas HuR overexpression promoted accumulation of the β-catenin protein in the cytoplasm. Thus, Wnt/β-catenin-mediated transcriptional activity in the nucleus was reduced by overexpressing HuR. These results suggest novel and uncharacterized cytoplasmic β-catenin functions related to HuR-mediated RNA metabolism in cancer cells

  4. Justice John Paul Stevens and the Erotic Boomerang.

    Science.gov (United States)

    Lieberman, Marc

    Justice John Paul Stevens of the United States Supreme Court has ruled on obscenity cases in seven instances since his appointment. His rulings reveal that he regards obscenity as a nuisance rather than as a danger threatening to undermine the nation's morality, that he supports a nationwide standard to adjudicate obscenity cases, and that he…

  5. Reframing Paul's sibling language in light of Jewish epistolary forms ...

    African Journals Online (AJOL)

    2015-06-17

    Jun 17, 2015 ... Reframing Paul's sibling language in light of Jewish epistolary forms of ... believers including Gentiles signals the re-definition of the family of Abraham. Read online: ..... Thirdly, some significant differences are detected between. Jewish ..... Rome (Moxnes 1980:78), and that 'the weak' in faith in. Romans 14 ...

  6. Surgical management of common bile duct stones at Saint Paul's ...

    African Journals Online (AJOL)

    Background: This study was aimed at evaluating the trend and outcome of surgical management of choledocholithiasis in St. Paul Teaching Hospital Addis Ababa, Ethiopia. Methods: This was a clinical based retrospective analysis. The operation register was used to identify the cases that were operated for biliary lithiasis.

  7. Constancy of character and Paul's understanding of change in his ...

    African Journals Online (AJOL)

    2010-11-21

    Nov 21, 2010 ... Paul's concern for explaining his own change in behaviour as positive and ... of fear of those of the circumcision (Gl 2:11–14), is not justified. ... have been changed by a divine call, and any further change of behaviour dishonours the divine ... Jewish Christians to which Betz appeals, as well as the idea that ...

  8. Paul, military imagery and social disadvantage | Punt | Acta ...

    African Journals Online (AJOL)

    In the past, attention for the social position or standing of the early Jesus followers was overrun by concerns for the theological and religious dimensions of those communities. The role of the Roman Empire and the impact of its military forces on the lives of people have generated even less attention. Paul's use of military ...

  9. Paul's community formation in 1 Thessalonians: The creation of ...

    African Journals Online (AJOL)

    2015-06-04

    Jun 4, 2015 ... Cho, K., Van Eck, E. & Wepener, ... Read online: .... Paul labels as 'the gospel of God' (1 Thes 2:2, 8–9) and 'the ..... Raymond Collins (1984) .... Van Eck, E., 2011, 'Social memory and identity: Luke 19:12b–24 and 27', Biblical.

  10. Improving Success in Developmental Mathematics: An Interview with Paul Nolting

    Science.gov (United States)

    Boylan, Hunter R.

    2011-01-01

    This article presents an interview with Dr. Paul Nolting, a national expert in assessing individual math learning problems, developing effective student learning strategies, and assessing institutional variables that affect math success. Since his dissertation in 1986 on improving math success with study skills Dr. Nolting has consulted with over…

  11. Paul Kard and Lorentz-free special relativity

    International Nuclear Information System (INIS)

    Karlov, L.

    1989-01-01

    The late Professor Paul Kard of Tartu, Estonia, worked on some interesting derivations of formulae from relativistic kinematics and the dependence of mass on speed. These may prove useful to physics educators as they break the mould of traditional textbook presentations. (UK)

  12. Paul Hillieri koor tõi Eestile Grammy / Immo Mihkelson

    Index Scriptorium Estoniae

    Mihkelson, Immo, 1959-

    2007-01-01

    2006. aasta septembris ilmunud plaadifirma Harmonia Mundi heliplaadi Arvo Pärt "Da Pacem", esitab Eesti Filharmoonia Kammerkoor, dirigent Paul Hillier Grammy võidust. Eesti Filharmoonia Kammerkoori koostööst USA plaadirmaga Harmonia Mundi. Grammy võitnud heliplaadist

  13. Alliksaar: rohkem kui legend / Paul-Eerik Rummo

    Index Scriptorium Estoniae

    Rummo, Paul-Eerik, 1942-

    2010-01-01

    Artur Alliksaare avaldusest, mis pärineb tema toimikust (NSVL Justiitsministeeriumi parandusliku töö laagrite režiimi- ja operatiivosakonna toimik nr. 5348). Avalduses annab Artur Alliksaar end üles kui Saksa sõjaväe vabatahtliku. Vt ka Paul-Eerik Rummo artiklit "Artur Alliksaare dokumenteeritud legend" ajakirjas Keel ja Kirjandus, 2003, nr. 4.

  14. The decapod and stomatopod Crustacea of St Paul's Rocks

    NARCIS (Netherlands)

    Holthuis, L.B.

    1980-01-01

    INTRODUCTION Saint Paul's Rocks (Penedos de São Pedro e São Paulo) are a small group of rocky islets on the mid-Atlantic ridge near the equator, occupying an area of roughly 250 by 425 m. There is no vegetation and, apart from birds and invertebrates, the islands are uninhabited. The Cambridge

  15. The Jesus of Paul: A contribution from the social sciences

    Directory of Open Access Journals (Sweden)

    Santiago Guijarro

    2011-04-01

    Determining the relationship between Jesus and Paul is one of the fundamental tasks of those who, like Prof. Andries van Aarde, study the origins of Christianity and the beginnings of Christian theology. The basic question in this regard, at least as it has been formulated recently by David Wenham (1995, is whether Paul was a follower of Jesus or the founder of Christianity (see also Wedderburn [1989] and Barbaglio [2006]. In this brief article, I would like to consider one aspect of this general topic and to offer a few suggestions that might contribute to a better understanding of the peculiar vision of Jesus that we find in the letters of Paul. In them, in fact, the apostle moves from the incarnation to the death and resurrection, leaving in the shadows the activity and teaching of Jesus to which the gospels subsequently give so much importance. This contrast raises some questions concerning the knowledge which Paul had of the Jesus tradition and the value he accorded to it: What did he know about Jesus? Did he know the traditions which the evangelists later collected? Why does he not refer to them in his letters more frequently? By contrast, why does he give so much importance to the death and resurrection of Jesus and to Jesus’ divine condition?

  16. Estudo da anomalia de Pelger-Huët em núcleo familiar Pelger-Huët anomaly study in a family

    Directory of Open Access Journals (Sweden)

    Patrícia H. O. Calderan

    2008-02-01

    Full Text Available The Pelger-Huët anomaly is a dominant autosomal disease, characterized by the incomplete segmentation of the granulocytes nucleus without lost of the cellular function. The heterozygotes form of this anomaly is assintomatic and it did not possess physic meant, while the homozygote form is rare and can be lethal, being therefore, important differentiates of other infectious alterations. The pseudo-anomaly can occasionally be observed in cases of granulocitic leukemia, mieloproliferatives Diseases, some infections and after exposition the determined drugs. We evaluate eleven members of a familiar nucleus and, after the blood cells analysis, six of then had presented neutrophils and eosinophils with nuclei characteristic of the heterozygotes form of the Pelger-Huët anomaly. The recognition of this leukocyte anomaly, mainly in patients without infection and presenting great number of not segmented neutrophils, can prevent wrong interpretations of the blood cells count and unnecessary clinical and therapeutically behaviors.

  17. Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain.

    Science.gov (United States)

    Tiruchinapalli, Dhanrajan M; Caron, Marc G; Keene, Jack D

    2008-12-01

    Growing evidence indicates that both seizure (glutamate) and cocaine (dopamine) treatment modulate synaptic plasticity within the mesolimbic region of the CNS. Activation of glutamatergic neurons depends on the localized translation of neuronal mRNA products involved in modulating synaptic plasticity. In this study, we demonstrate the dendritic localization of HuR and HuD RNA-binding proteins (RBPs) and their association with neuronal mRNAs following these two paradigms of seizure and cocaine treatment. Both the ubiquitously expressed HuR and neuronal HuD RBPs were detected in different regions as well as within dendrites of the brain and in dissociated neurons. Quantitative analysis revealed an increase in HuR, HuD and p-glycogen synthase kinase 3beta (GSK3beta) protein levels as well as neuronal mRNAs encoding Homer, CaMKIIalpha, vascular early response gene, GAP-43, neuritin, and neuroligin protein products following either seizure or cocaine treatment. Inhibition of the Akt/GSK3beta signaling pathway by acute or chronic LiCl treatment revealed changes in HuR, HuD, pGSK3beta, p-Akt, and beta-catenin protein levels. In addition, a genetically engineered hyperdopaminergic mouse model (dopamine transporter knockout) revealed decreased expression of HuR protein levels, but no significant change was observed in HuD or fragile-X mental retardation protein RBPs. Finally, our data suggest that HuR and HuD RBPs potentially interact directly with neuronal mRNAs important for differentiation and synaptic plasticity.

  18. An experimental study of mechanism in treatment for endometriosis with Xiao Chai Hu Tang in rats

    International Nuclear Information System (INIS)

    Zhang Hui; Zuo Liandong; Li Hongyi

    2005-01-01

    To explore the mechanism of Xiao Chai Hu Tang in treatment for endometriosis in rats, the rat model of endometriosis was established. Using immunohistochemistry method, Fas and Caspase-3 protein expression in endometrium and endometriotic tissue of each group were observed. The results showed that in the group treated with Xiao Chai Hu Tang, the protein expressions of Fas and Caspase-3 in endometriotic tissue were higher than those in endometrium, while in the control group, the result was just opposite. The difference was not obvious in the group treated with Danazol . The higher levels of the protein expression of Fas in endometriotic tissue may related to the pathogenesis of the endometriosis. The mechanism of Xiao Chai Hu Tang treatment may be partly to increase apoptosis in endometriotic tissue. (authors)

  19. Effets des sels organiques de tributyletain sur l'huître adulte Crassostrea gigas

    OpenAIRE

    Heral, Maurice; Alzieu, Claude; Caux, O.; Razet, Daniel; Garnier, Jacqueline

    1983-01-01

    La toxicité des composés organostanniques a été mise en évidence à l'égard de l'huître Crassostrea gigas tant aux stades larvaires (His & Robert, 1980) que chez l'adulte (Alzieu & al., 1980, 1981). Parallèlement ces mêmes auteurs ont montré l'accumulation d'étain dans les huîtres contaminées expérimentalement ainsi que le rôle que peut jouer le fluorure de TBT dans la perturbation de la croissance (Héral & al. 1981) et dans la malformation de la coquille des huîtres (Alzieu & al., 1981). Dans...

  20. Nilai Kalor Bakar Limbah Padat (HuWAC Sebagai Bahan Bakar Alternatif dalam Produksi Batu Bata

    Directory of Open Access Journals (Sweden)

    Soeparjono Soeparjono

    2009-02-01

    Full Text Available Menipisnya persediaan minyak bumi dan sulitnya mendapatkan kayu bakar dengan harga murah sebagai bahan bakar untuk kalangan industri kecil produksi batu bata, diperlukan adanya pemikiran mencari bahan bakar alternatif dan murah. Penelitian ini bertujuan mengetahui nilai kalor bakar limbah HuWAC sebagai bahan bakar alternatif untuk produksi batu merah. Sasarannya limbah HuWAC pabrik monosodium glutamat AJINOMOTO Mojokerto dengan sampel acak yang dikeringkan panas matahari. Penelitian menggunakan pendekatan kuantitatif rancangan deskriptif. Unsur-unsur yang terbakar dalam sampel dilakukan koreksi. Pengambilan data dilakukan secara langsung dengan alat Kalorimeter. Hasil penelitian menunjukkan bahwa nilai kalor bakar yang dihitung dengan formula Dulong, LVH = 2614 kcal/kg dan HHV = 2745 kcal/kg, sedangkan dari alat Kalorimeter Hgr = 2728 kcal/kg. Hal ini menunjukkan bahwa HuWAC dapat digunakan sebagai bahan bakar alternatif di kalangan industri kecil produksi batu bata.

  1. HuMOVE: a low-invasive wearable monitoring platform in sexual medicine.

    Science.gov (United States)

    Ciuti, Gastone; Nardi, Matteo; Valdastri, Pietro; Menciassi, Arianna; Basile Fasolo, Ciro; Dario, Paolo

    2014-10-01

    To investigate an accelerometer-based wearable system, named Human Movement (HuMOVE) platform, designed to enable quantitative and continuous measurement of sexual performance with minimal invasiveness and inconvenience for users. Design, implementation, and development of HuMOVE, a wearable platform equipped with an accelerometer sensor for monitoring inertial parameters for sexual performance assessment and diagnosis, were performed. The system enables quantitative measurement of movement parameters during sexual intercourse, meeting the requirements of wearability, data storage, sampling rate, and interfacing methods, which are fundamental for human sexual intercourse performance analysis. HuMOVE was validated through characterization using a controlled experimental test bench and evaluated in a human model during simulated sexual intercourse conditions. HuMOVE demonstrated to be a robust and quantitative monitoring platform and a reliable candidate for sexual performance evaluation and diagnosis. Characterization analysis on the controlled experimental test bench demonstrated an accurate correlation between the HuMOVE system and data from a reference displacement sensor. Experimental tests in the human model during simulated intercourse conditions confirmed the accuracy of the sexual performance evaluation platform and the effectiveness of the selected and derived parameters. The obtained outcomes also established the project expectations in terms of usability and comfort, evidenced by the questionnaires that highlighted the low invasiveness and acceptance of the device. To the best of our knowledge, HuMOVE platform is the first device for human sexual performance analysis compatible with sexual intercourse; the system has the potential to be a helpful tool for physicians to accurately classify sexual disorders, such as premature or delayed ejaculation. Copyright © 2014 Elsevier Inc. All rights reserved.

  2. [From Paul Flechsig to the Paul Flechsig Institute for Brain Research. Development of brain research at the Karl Marx University].

    Science.gov (United States)

    Leibnitz, L; Werner, L; Schober, W; Brauer, K

    1977-04-01

    A review is given on the development of the brain research institute of the Karl-Marx-University of Leipzig during the directorates of Paul Flechsig (1883-1920), Richard Arwed Pfeifer (1925-1957), and Wolfgang Wünscher (1957-1971).

  3. High quality draft genome sequence of Staphylococcus cohnii subsp. cohnii strain hu-01.

    Science.gov (United States)

    Hu, XinJun; Li, Ang; Lv, LongXian; Yuan, Chunhui; Guo, Lihua; Jiang, Xiawei; Jiang, Haiyin; Qian, GuiRong; Zheng, BeiWen; Guo, Jing; Li, LanJuan

    2014-06-15

    Staphylococcus cohnii subsp. cohnii belongs to the family Staphylococcaceae in the order Bacillales, class Bacilli and phylum Firmicutes. The increasing relevance of S. cohnii to human health prompted us to determine the genomic sequence of Staphylococcus cohnii subsp. cohnii strain hu-01, a multidrug-resistant isolate from a hospital in China. Here we describe the features of S. cohnii subsp. cohnii strain hu-01, together with the genome sequence and its annotation. This is the first genome sequence of the species Staphylococcus cohnii.

  4. Different modes of interaction by TIAR and HuR with target RNA and DNA

    OpenAIRE

    Kim, Henry S.; Wilce, Matthew C. J.; Yoga, Yano M. K.; Pendini, Nicole R.; Gunzburg, Menachem J.; Cowieson, Nathan P.; Wilson, Gerald M.; Williams, Bryan R. G.; Gorospe, Myriam; Wilce, Jacqueline A.

    2011-01-01

    TIAR and HuR are mRNA-binding proteins that play important roles in the regulation of translation. They both possess three RNA recognition motifs (RRMs) and bind to AU-rich elements (AREs), with seemingly overlapping specificity. Here we show using SPR that TIAR and HuR bind to both U-rich and AU-rich RNA in the nanomolar range, with higher overall affinity for U-rich RNA. However, the higher affinity for U–rich sequences is mainly due to faster association with U-rich RNA, which we propose i...

  5. Meandering Musings by Linus Pauling: "American Scientists and the Spirit of the Frontier".

    Science.gov (United States)

    Bause, George S

    2016-04-01

    Hoping to raise funds in 1975 for his namesake institute, Linus Pauling submitted to Esquire magazine a 32-page handwritten manuscript, "American Scientists and the Spirit of the Frontier." Angered when his submission for publication was declined, Pauling eventually gifted the original manuscript in 1986 to his friend, Linus Pauling Institute fundraiser Stephen Maddox, who would sell it in 2004 to the Wood Library-Museum of Anesthesiology. Published accurately here for the first time, the manuscript captures not only Pauling's sweeping metaphor of scientists as frontiersmen but also the creative process by which Pauling formulated his hydrate microcrystal theory of general anesthesia. Copyright © 2015 Elsevier Inc. All rights reserved.

  6. Nuevos centros de almacenamiento inca en Huánuco Pampa

    OpenAIRE

    Ordóñez Inga, Carlo José Alonso

    2013-01-01

    Se proporcionan nuevos alcances sobre la identificación y el estudio de nuevos lugares de almacenamiento o colcas asociados al Centro Administrativo Inca de Huánuco Pampa, los mismos que no fueron reconocidos por otros investigadores que trabajaron en la zona.

  7. Rare Association of Anti-Hu Antibody Positive Paraneoplastic Neurological Syndrome and Transitional Cell Bladder Carcinoma

    Directory of Open Access Journals (Sweden)

    S. Lukacs

    2012-01-01

    Full Text Available Introduction. Paraneoplastic encephalomyelitis (PEM and subacute sensory neuronopathy (SSN are remote effects of cancer, usually associated with small-cell lung carcinoma and positive anti-Hu antibody. We describe the rare association of bladder transitional cell carcinoma (TCC with anti-Hu antibody positivity resulting in this paraneoplastic neurological syndrome. Patient. A 76-year-old female presented with bilateral muscle weakness and paraesthesia of the upper and lower limbs in a length-dependent “glove and stocking” distribution. Central nervous system symptoms included cognitive problems, personality change, and truncal ataxia. Case notes and the literature were reviewed. Result. Autoantibody screening was positive for anti-Hu antibody (recently renamed antineuronal nuclear antibody 1, ANNA-1. The diagnosis of PEM and SSN was supported by MRI and lumbar puncture results. A superficial bladder TCC was demonstrated on CT and subsequently confirmed on histology. No other primary neoplasm was found on full-body imaging. The neurological symptoms were considered to be an antibody-mediated paraneoplastic neurological syndrome and improved after resection of the tumour. Discussion. The association of anti-Hu positive paraneoplastic neurological syndrome and TCC has not been described in the literature previously. We emphasize the need for detailed clinical examination and the importance of a multidisciplinary thought process and encourage further awareness of this rare association.

  8. The herbal mixture Xiao-Chai-Hu Tang (XCHT) induces apoptosis of ...

    African Journals Online (AJOL)

    Background: Xiao-Chai-Hu Tang (XCHT) is an extract of seven herbs with anticancer properties, but its mechanism of action is unknown. In this study, we evaluated XCHT-treated hepatocellular carcinoma (HCC) for anti-proliferative and pro-apoptotic effects. Materials and Methods: Using a hepatic cancer xenograft model, ...

  9. Extended Hu¨ckel Calculations on Solids Using the Avogadro Molecular Editor and Visualizer

    Science.gov (United States)

    Avery, Patrick; Ludoweig, Herbert; Autschbach, Jochen; Zurek, Eva

    2018-01-01

    The "Yet Another extended Hu¨ckel Molecular Orbital Package" (YAeHMOP) has been merged with the Avogadro open-source molecular editor and visualizer. It is now possible to perform YAeHMOP calculations directly from the Avogadro graphical user interface for materials that are periodic in one, two, or three dimensions, and to visualize…

  10. Stable Trapping of Multielectron Helium Bubbles in a Paul Trap

    Science.gov (United States)

    Joseph, E. M.; Vadakkumbatt, V.; Pal, A.; Ghosh, A.

    2017-06-01

    In a recent experiment, we have used a linear Paul trap to store and study multielectron bubbles (MEBs) in liquid helium. MEBs have a charge-to-mass ratio (between 10^{-4} and 10^{-2} C/kg) which is several orders of magnitude smaller than ions (between 10^6 and 10^8 C/kg) studied in traditional ion traps. In addition, MEBs experience significant drag force while moving through the liquid. As a result, the experimental parameters for stable trapping of MEBs, such as magnitude and frequency of the applied electric fields, are very different from those used in typical ion trap experiments. The purpose of this paper is to model the motion of MEBs inside a linear Paul trap in liquid helium, determine the range of working parameters of the trap, and compare the results with experiments.

  11. The Personal Tragedy in Paul Hindemith's Mathis de Maler

    Directory of Open Access Journals (Sweden)

    Sharri K Hall

    2018-03-01

    Full Text Available Paul Hindemith is hardly remembered for his music prior to the 1940s. During the Nazi occupation of Germany in the early 20th century, Paul Hindemith, reviled for his modernistic styles and relation to his Jewish wife, was forced to emigrate out of the Third Reich for his safety. Hindemith was known for his connections to New Objectivity, Gebrachsmusik, and tonality instability placed him in the wrong realm of composition in the Nazi’s minds. As Hitler rose to power in 1933, Hindemith knew he would need a composition to prove his worth amongst the Nazis. As such, Hindemith attempted to change his tides through the composition of the opera/symphony Mathis der Maler. Mathis featured the strong tonality, German nationalism, and Romantic monumentality the Nazis were hoping for to strengthen their regime and the global understanding of German culture. However, Mathis also illustrated Hindemith’s personal pains and struggles with the Reich.

  12. The research contributions of Dr. Paul Van Deusen

    Science.gov (United States)

    Thomas B. Lynch; Francis A. Roesch; John Paul McTague; Jeffrey H. Gove; Gregory A. Reams; Aaron R. Weiskittel

    2015-01-01

    Dr. Paul Van Deusen’s recent passing concluded a rich 30+-year research career dedicated to development and implementation of quantitative methods for forestry and natural resources. Since the early part of his career as a biometrician with the USDA Forest Service Southern Research Station in the 1980s-1990s and continuing with his later employment at NCASI, Dr. Van...

  13. The Italian origins of FAO and Paul Otlet

    OpenAIRE

    Guarasci, Roberto; Taverniti, Maria

    2016-01-01

    Nowadays the strategic role of international organizations, which manage and provide information systems and library services in the agricultural domain, is universally recognized. This paper focuses on the origin of the Food and Agriculture Organization of the United Nations (FAO) by presenting a critical edition of the Rapport by Paul Otlet to the marquis Cappelli, pr?sident de l?Institut International d?Agricolture (Otlet, 1911) that includes original documents and outlines the first steps...

  14. A DOCUMENT PAUL AUSTER’S NEW YORK TRILOGY

    Directory of Open Access Journals (Sweden)

    Natalia N. Smirnova

    2017-03-01

    Full Text Available The article deals with the way a literary work “creates” a document out of itself, on the example of Paul Auster’s novels. A document here is the report of a character, a private detective who is watching another character (a writer but also the book of a fictional writer who is writing a story of the detective who is watching him, and eventually the book about this whole story. In this case, the search for the other, watching him, is inevitably associated with the search for oneself, self-observation. Biography becomes autobiography, e.g. a document rather than a narrative based on a document. This story becomes projected on the story of Don Quixote (of which “some” Paul Auster, a fictional writer, is writing an essay. The Other is a landmark in the vast desert of fictional worlds where Paul Auster’s Don Quixote wanders alongside other characters of the trilogy. The author may not return from his endless journey through imaginary worlds; his life does not belong to either real life or fiction. He gives life to his characters while remaining invisible himself. Paul Auster’s The New York Trilogy explores such existential situation where the only evidence of the author’s life is a document left by his character. The author leaves a documentary record of a kind about his own existence. It this sense, literature is a document of life and of the endless search for a reason to the existence of an individual who, being not equal to him- or herself, is always the other and never a type or a template.

  15. The Sagnac effect and its interpretation by Paul Langevin

    Science.gov (United States)

    Pascoli, Gianni

    2017-11-01

    The French physicist Georges Sagnac is nowdays frequently cited by the engineers who work on devices such as ring-laser gyroscopes. These systems operate on the principle of the Sagnac effect. It is less known that Sagnac was a strong opponent to the theory of special relativity proposed by Albert Einstein. He set up his experiment to prove the existence of the aether discarded by the Einsteinian relativity. An accurate explanation of the phenomenon was provided by Paul Langevin in 1921.

  16. Paul Ion Trap as a Diagnostic for Plasma Focus

    Science.gov (United States)

    Sadat Kiai, S. M.; Adlparvar, S.; Zirak, A.; Alhooie, Samira; Elahi, M.; Sheibani, S.; Safarien, A.; Farhangi, S.; Dabirzadeh, A. A.; Khalaj, M. M.; Mahlooji, M. S.; KaKaei, S.; Talaei, A.; Kashani, A.; Tajik Ahmadi, H.; Zahedi, F.

    2010-02-01

    The plasma discharge contamination by high and low Z Impurities affect the rate of nuclear fusion reaction products, specially when light particles have to be confined. These impurities should be analyzed and can be fairly controlled. This paper reports on the development of a Paul ion trap with ion sources by impact electron ionization as a diagnostic for the 10 kJ Iranian sunshine plasma focus device. Preliminary results of the residual gas are analyzed and presented.

  17. Simultaneous Administration of ADSCs-Based Therapy and Gene Therapy Using Ad-huPA Reduces Experimental Liver Fibrosis.

    Science.gov (United States)

    Meza-Ríos, Alejandra; García-Benavides, Leonel; García-Bañuelos, Jesus; Salazar-Montes, Adriana; Armendáriz-Borunda, Juan; Sandoval-Rodríguez, Ana

    2016-01-01

    hADSCs transplantation in cirrhosis models improves liver function and reduces fibrosis. In addition, Ad-huPA gene therapy diminished fibrosis and increased hepatocyte regeneration. In this study, we evaluate the combination of these therapies in an advanced liver fibrosis experimental model. hADSCs were expanded and characterized before transplantation. Ad-huPA was simultaneously administrated via the ileac vein. Animals were immunosuppressed by CsA 24 h before treatment and until sacrifice at 10 days post-treatment. huPA liver expression and hADSCs biodistribution were evaluated, as well as the percentage of fibrotic tissue, hepatic mRNA levels of Col-αI, TGF-β1, CTGF, α-SMA, PAI-I, MMP2 and serum levels of ALT, AST and albumin. hADSCs homed mainly in liver, whereas huPA expression was similar in Ad-huPA and hADSCs/Ad-huPA groups. hADSCs, Ad-huPA and hADSCs/Ad-huPA treatment improves albumin levels, reduces liver fibrosis and diminishes Collagen α1, CTGF and α-SMA mRNA liver levels. ALT and AST serum levels showed a significant decrease exclusively in the hADSCs group. These results showed that combinatorial effect of cell and gene-therapy does not improve the antifibrogenic effects of individual treatments, whereas hADSCs transplantation seems to reduce liver fibrosis in a greater proportion.

  18. Immunostimulatory effects of natural human interferon-alpha (huIFN-alpha) on carps Cyprinus carpio L.

    Science.gov (United States)

    Watanuki, Hironobu; Chakraborty, Gunimala; Korenaga, Hiroki; Kono, Tomoya; Shivappa, R B; Sakai, Masahiro

    2009-10-15

    Human interferon-alpha (huIFN-alpha) is an important immunomodulatory substance used in the treatment and prevention of numerous infectious and immune-related diseases in animals. However, the immunostimulatory effects of huIFN-alpha in fish remain to be investigated. In the current study, the immune responses of the carp species Cyprinus carpio L. to treatment with huIFN-alpha were analyzed via measurement of superoxide anion production, phagocytic activity and the expression of cytokine genes including interleukin-1beta, tumor necrosis factor-alpha and interleukin 10. Low doses of huIFN-alpha were administered orally once a day for 3 days, and sampling was carried out at 1, 3 and 5 days post-treatment. Our results indicate that a low dose of huIFN-alpha significantly increased phagocytic activity and superoxide anion production in the carp kidney. The huIFN-alpha-treated fish also displayed a significant upregulation in cytokine gene expression. The current study demonstrates the stimulatory effects of huIFN-alpha on the carp immune system and highlights the immunomodulatory role of huIFN-alpha in fish.

  19. The Urgency for Peace in Teachings of John Paul II

    Directory of Open Access Journals (Sweden)

    Jerzy Lewandowski

    2014-04-01

    Full Text Available Peace has always been a topic of great importance. Its presence is desired by all nations and societies. It brings the world together in unity. John Paul II considered peace to be an integral part in creation of an independent and healthy society. Papal encyclicals and messages, intended to present the response of the teaching Church to problems that arise from time to time, often dwell on the principles that advocate peace. Since freedom and peace are in many cases a privilege for many nations, the mentioned pope commits himself to speak about the cruelty and evilness of wars and national conflicts. Pope John Paul II denounces intolerance as denial of freedom for many people, and consequently a great threat to peace. The pope teaches that peace has its roots in the family. Yet, in many societies, the family is deprived of the utmost importance that it certainly deserves. Without the adequate means for a decent livelihood, families can experience hardship in committing themselves to promote solidarity and a proper social fabric worthy of human dignity. For John Paul II, a nation’s freedom and peace are safeguarded and promoted through particular attention and a much-devoted effort by strong and healthy families.

  20. Modern historical epistemology through the prism of Paul Ricoeur’ transactions

    Directory of Open Access Journals (Sweden)

    Trubnikova Natalia

    2016-01-01

    Full Text Available In this article it is carried out the contribution of Paul Ricoeur, the leading theorist of modern humanitarian knowledge, in the elaboration of the modern historical epistemology problems. His diverse works affect all sense fields of history and historical perception. The article shows the place of Paul Ricoeur as a primary guide of philosophical hermeneutic tradition achievements in the sphere of historical research, moreover, as a thinker, who gives a principal possibility to surmount divisions of different historiographical trends and find a methodological consensus in regard to basic orientations of historical scholarship. On the basis of his works the dialectic of a historical objectivity and a personal subjectivity of historian, the interoperability issues of history and historical memory are traced. At the same time this paper touches principals dichotomies, basic for the Paul Ricoeur’s considerations, such as fiction and historical narration, structure and event, history and truth, memory and imagination, scientism and art of interpretation, human action and social constraint. The contents of a current debate on the theory of history, based on the development of the Ricoeur’s “defatalisation” of history concept and utopian future vision are shown.

  1. Cold highly charged ions in a cryogenic Paul trap

    Energy Technology Data Exchange (ETDEWEB)

    Versolato, O. O., E-mail: oscar.versolato@mpi-hd.mpg.de; Schwarz, M.; Windberger, A.; Ullrich, J. [Max-Planck-Institut fuer Kernphysik (Germany); Schmidt, P. O. [Physikalisch-Technische Bundesanstalt (Germany); Drewsen, M. [University of Aarhus, Department of Physics and Astronomy (Denmark); Crespo Lopez-Urrutia, J. R. [Max-Planck-Institut fuer Kernphysik (Germany)

    2013-03-15

    Narrow optical transitions in highly charged ions (HCIs) are of particular interest for metrology and fundamental physics, exploiting the high sensitivity of HCIs to new physics. The highest sensitivity for a changing fine structure constant ever predicted for a stable atomic system is found in Ir{sup 17 + }. However, laser spectroscopy of HCIs is hindered by the large ({approx} 10{sup 6} K) temperatures at which they are produced and trapped. An unprecedented improvement in such laser spectroscopy can be obtained when HCIs are cooled down to the mK range in a linear Paul trap. We have developed a cryogenic linear Paul trap in which HCIs will be sympathetically cooled by {sup 9}Be{sup + } ions. Optimized optical access for laser light is provided while maintaining excellent UHV conditions. The Paul trap will be connected to an electron beam ion trap (EBIT) which is able to produce a wide range of HCIs. This EBIT will also provide the first experimental input needed for the determination of the transition energies in Ir{sup 17 + }, enabling further laser-spectroscopic investigations of this promising HCI.

  2. Drug Transporter Expression and Activity in Human Hepatoma HuH-7 Cells

    Directory of Open Access Journals (Sweden)

    Elodie Jouan

    2016-12-01

    Full Text Available Human hepatoma cells may represent a valuable alternative to the use of human hepatocytes for studying hepatic drug transporters, which is now a regulatory issue during drug development. In the present work, we have characterized hepatic drug transporter expression, activity and regulation in human hepatoma HuH-7 cells, in order to determine the potential relevance of these cells for drug transport assays. HuH-7 cells displayed notable multidrug resistance-associated protein (MRP activity, presumed to reflect expression of various hepatic MRPs, including MRP2. By contrast, they failed to display functional activities of the uptake transporters sodium taurocholate co-transporting polypeptide (NTCP, organic anion-transporting polypeptides (OATPs and organic cation transporter 1 (OCT1, and of the canalicular transporters P-glycoprotein and breast cancer resistance protein (BCRP. Concomitantly, mRNA expressions of various sinusoidal and canalicular hepatic drug transporters were not detected (NTCP, OATP1B1, organic anion transporter 2 (OAT2, OCT1 and bile salt export pump or were found to be lower (OATP1B3, OATP2B1, multidrug and toxin extrusion protein 1, BCRP and MRP3 in hepatoma HuH-7 cells than those found in human hepatocytes, whereas other transporters such as OAT7, MRP4 and MRP5 were up-regulated. HuH-7 cells additionally exhibited farnesoid X receptor (FXR- and nuclear factor erythroid 2-related factor 2 (Nrf2-related up-regulation of some transporters. Such data indicate that HuH-7 cells, although expressing rather poorly some main hepatic drug transporters, may be useful for investigating interactions of drugs with MRPs, notably MRP2, and for studying FXR- or Nrf2-mediated gene regulation.

  3. Transcriptomic-Wide Discovery of Direct and Indirect HuR RNA Targets in Activated CD4+ T Cells.

    Directory of Open Access Journals (Sweden)

    Patsharaporn Techasintana

    Full Text Available Due to poor correlation between steady state mRNA levels and protein product, purely transcriptomic profiling methods may miss genes posttranscriptionally regulated by RNA binding proteins (RBPs and microRNAs (miRNAs. RNA immunoprecipitation (RIP methods developed to identify in vivo targets of RBPs have greatly elucidated those mRNAs which may be regulated via transcript stability and translation. The RBP HuR (ELAVL1 and family members are major stabilizers of mRNA. Many labs have identified HuR mRNA targets; however, many of these analyses have been performed in cell lines and oftentimes are not independent biological replicates. Little is known about how HuR target mRNAs behave in conditional knock-out models. In the present work, we performed HuR RIP-Seq and RNA-Seq to investigate HuR direct and indirect targets using a novel conditional knock-out model of HuR genetic ablation during CD4+ T activation and Th2 differentiation. Using independent biological replicates, we generated a high coverage RIP-Seq data set (>160 million reads that was analyzed using bioinformatics methods specifically designed to find direct mRNA targets in RIP-Seq data. Simultaneously, another set of independent biological replicates were sequenced by RNA-Seq (>425 million reads to identify indirect HuR targets. These direct and indirect targets were combined to determine canonical pathways in CD4+ T cell activation and differentiation for which HuR plays an important role. We show that HuR may regulate genes in multiple canonical pathways involved in T cell activation especially the CD28 family signaling pathway. These data provide insights into potential HuR-regulated genes during T cell activation and immune mechanisms.

  4. THE APOSTLE PAUL: THEOLOGIAN-MISSIONARY AND PASTOR-THEOLOGIAN. TOWARDS A DEEPER UNDERSTANDING OF SAINT PAUL

    Directory of Open Access Journals (Sweden)

    Eckhart Schnabel

    2013-04-01

    Full Text Available This Article is an attempt to shed light on a few texts of the acts of the Apostles and of the epistles which are viewed as sources documenting the life and activity of Saint Paul. The author attempts to settle a number of questions regarding the authenticity of sources illustrating the life of Saint Paul. Similar questions are often raised by those who write and publish guides and textbooks for the teaching of the Pauline corpus. The author agrees with the overwhelming positive judgment of the academic world regarding the authenticity of the pastoral epistles, but at the same time he notes a number of objections to their authenticity proposed by the same forum: inconsistencies within the vocabulary of the texts themselves, their linguistic style, and their theological argumentation. The author concludes that these objections are inconclusive and the features enumerated by those who object constitute in reality only minor exceptions, inconsequential when taking into account the entire Pauline corpus. The author also examines the authenticity and historical accuracy of the account of the life of Saint Paul as given in the Acts of the Apostles. A few Biblicists claim that the account in Acts is merely legendary and is to be regarded as a type of early Christian folklore. The author disagrees with this opinion, backing up his position with the evidence that both the Acts of the Apostles and the Pastoral Epistles agree in historical detail and background. The author concludes with a further consideration regarding the correct method guiding biblical research on Saint Paul. He opines that such research must view the biblical texts in a correct historical perspective

  5. WE-AB-202-06: Correlating Lung CT HU with Transformation-Based and Xe-CT Derived Ventilation

    International Nuclear Information System (INIS)

    Du, K; Patton, T; Bayouth, J; Reinhardt, J; Christensen, G

    2016-01-01

    Purpose: Regional lung ventilation is useful to reduce radiation-induced function damage during lung cancer radiation therapy. Recently a new direct HU (Hounsfield unit)-based method was proposed to estimate the ventilation potential without image registration. The purpose of this study is to examine if there is a functional dependence between HU values and transformation-based or Xe-CT derived ventilation. Methods: 4DCT images acquired from 13 patients prior to radiation therapy and 4 mechanically ventilated sheep subjects which also have associated Xe-CT images were used for this analysis. Transformation-based ventilation was computed using Jacobian determinant of the transformation field between peak-exhale and peak-inhale 4DCT images. Both transformation and Xe-CT derived ventilation was computed for each HU bin. Color scatter plot and cumulative histogram were used to compare and validate the direct HU-based method. Results: There was little change of the center and shape of the HU histograms between free breathing CT and 4DCT average, with or without smoothing, and between the repeated 4DCT scans. HU of −750 and −630 were found to have the greatest transformation-based ventilation for human and sheep subjects, respectively. Maximum Xe-CT derived ventilation was found to locate at HU of −600 in sheep subjects. The curve between Xe-CT ventilation and HU was noisy for tissue above HU −400, possibly due to less intensity change of Xe gas during wash-out and wash-in phases. Conclusion: Both transformation-based and Xe-CT ventilation demonstrated that lung tissues with HU values in the range of (-750, −600) HU have the maximum ventilation potential. The correlation between HU and ventilation suggests that HU might be used to help guide the ventilation calculation and make it more robust to noise and image registration errors. Research support from NIH grants CA166703 and CA166119 and a gift from Roger Koch.

  6. WE-AB-202-06: Correlating Lung CT HU with Transformation-Based and Xe-CT Derived Ventilation

    Energy Technology Data Exchange (ETDEWEB)

    Du, K; Patton, T; Bayouth, J [University of Wisconsin, Madison, WI (United States); Reinhardt, J; Christensen, G [The University of Iowa, Iowa City, IA (United States)

    2016-06-15

    Purpose: Regional lung ventilation is useful to reduce radiation-induced function damage during lung cancer radiation therapy. Recently a new direct HU (Hounsfield unit)-based method was proposed to estimate the ventilation potential without image registration. The purpose of this study is to examine if there is a functional dependence between HU values and transformation-based or Xe-CT derived ventilation. Methods: 4DCT images acquired from 13 patients prior to radiation therapy and 4 mechanically ventilated sheep subjects which also have associated Xe-CT images were used for this analysis. Transformation-based ventilation was computed using Jacobian determinant of the transformation field between peak-exhale and peak-inhale 4DCT images. Both transformation and Xe-CT derived ventilation was computed for each HU bin. Color scatter plot and cumulative histogram were used to compare and validate the direct HU-based method. Results: There was little change of the center and shape of the HU histograms between free breathing CT and 4DCT average, with or without smoothing, and between the repeated 4DCT scans. HU of −750 and −630 were found to have the greatest transformation-based ventilation for human and sheep subjects, respectively. Maximum Xe-CT derived ventilation was found to locate at HU of −600 in sheep subjects. The curve between Xe-CT ventilation and HU was noisy for tissue above HU −400, possibly due to less intensity change of Xe gas during wash-out and wash-in phases. Conclusion: Both transformation-based and Xe-CT ventilation demonstrated that lung tissues with HU values in the range of (-750, −600) HU have the maximum ventilation potential. The correlation between HU and ventilation suggests that HU might be used to help guide the ventilation calculation and make it more robust to noise and image registration errors. Research support from NIH grants CA166703 and CA166119 and a gift from Roger Koch.

  7. The Elav-like protein HuR exerts translational control of viral internal ribosome entry sites

    International Nuclear Information System (INIS)

    Rivas-Aravena, Andrea; Ramdohr, Pablo; Vallejos, Maricarmen; Valiente-Echeverria, Fernando; Dormoy-Raclet, Virginie; Rodriguez, Felipe; Pino, Karla; Holzmann, Cristian; Huidobro-Toro, J. Pablo; Gallouzi, Imed-Eddine; Lopez-Lastra, Marcelo

    2009-01-01

    The human embryonic-lethal abnormal vision (ELAV)-like protein, HuR, has been recently found to be involved in the regulation of protein synthesis. In this study we show that HuR participates in the translational control of the HIV-1 and HCV IRES elements. HuR functions as a repressor of HIV-1 IRES activity and acts as an activator of the HCV IRES. The effect of HuR was evaluated in three independent experimental systems, rabbit reticulocyte lysate, HeLa cells, and Xenopus laevis oocytes, using both overexpression and knockdown approaches. Furthermore, results suggest that HuR mediated regulation of HIV-1 and HCV IRESes does not require direct binding of the protein to the RNA nor does it need the nuclear translocation of the IRES-containing RNAs. Finally, we show that HuR has a negative impact on post-integration steps of the HIV-1 replication cycle. Thus, our observations yield novel insights into the role of HuR in the post-transcriptional regulation of HCV and HIV-1 gene expression.

  8. HuR/ELAVL1 RNA binding protein modulates interleukin-8 induction by muco-active ribotoxin deoxynivalenol

    International Nuclear Information System (INIS)

    Choi, Hye Jin; Yang, Hyun; Park, Seong Hwan; Moon, Yuseok

    2009-01-01

    HuR/Elav-like RNA binding protein 1 (ELAVL1) positively regulates mRNA stability of AU-rich elements (ARE)-containing transcript such as pro-inflammatory cytokines. Ribotoxic stresses can trigger the production of pro-inflammatory mediators by enhancing mRNA stability and the transcriptional activity. We investigated the effects of ribotoxin deoxynivalenol (DON) on HuR translocation and its involvement in the regulation of the pro-inflammatory interleukin-8 (IL-8) mRNA stability. Exposure to the muco-active DON induced nuclear export of both endogenous and exogenous HuR RNA binding protein in human intestinal epithelial cells. Moreover, the interference with HuR protein production suppressed ribotoxic DON-induced IL-8 secretion and its mRNA stability. Cytoplasmic HuR protein interacted with IL-8 mRNA and the complex stabilization was due to the presence of 3'-untranslated region of the transcript. Partly in terms of IL-8-modulating transcription factors, HuR protein was demonstrated to be positively and negatively associated with DON-induced early growth response gene 1 (EGR-1) and activating transcription factor 3 (ATF3), respectively. HuR was a critical mechanistic link between ribotoxic stress and the pro-inflammatory cytokine production, and may have a broader functional significance with regard to mucosal insults since ribotoxic stress responses are also produced upon interactions with the diverse environment of gut.

  9. SU-E-T-470: Importance of HU-Mass Density Calibration Technique in Proton Pencil Beam Dose Calculation

    Energy Technology Data Exchange (ETDEWEB)

    Penfold, S; Miller, A [University of Adelaide, Adelaide, SA (Australia)

    2015-06-15

    Purpose: Stoichiometric calibration of Hounsfield Units (HUs) for conversion to proton relative stopping powers (RStPs) is vital for accurate dose calculation in proton therapy. However proton dose distributions are not only dependent on RStP, but also on relative scattering power (RScP) of patient tissues. RScP is approximated from material density but a stoichiometric calibration of HU-density tables is commonly neglected. The purpose of this work was to quantify the difference in calculated dose of a commercial TPS when using HU-density tables based on tissue substitute materials and stoichiometric calibrated ICRU tissues. Methods: Two HU-density calibration tables were generated based on scans of the CIRS electron density phantom. The first table was based directly on measured HU and manufacturer quoted density of tissue substitute materials. The second was based on the same CT scan of the CIRS phantom followed by a stoichiometric calibration of ICRU44 tissue materials. The research version of Pinnacle{sup 3} proton therapy was used to compute dose in a patient CT data set utilizing both HU-density tables. Results: The two HU-density tables showed significant differences for bone tissues; the difference increasing with increasing HU. Differences in density calibration table translated to a difference in calculated RScP of −2.5% for ICRU skeletal muscle and 9.2% for ICRU femur. Dose-volume histogram analysis of a parallel opposed proton therapy prostate plan showed that the difference in calculated dose was negligible when using the two different HU-density calibration tables. Conclusion: The impact of HU-density calibration technique on proton therapy dose calculation was assessed. While differences were found in the calculated RScP of bony tissues, the difference in dose distribution for realistic treatment scenarios was found to be insignificant.

  10. Metabolic aspects of growth in HU-treated crown-gall tissue cultures. I. Nicotiana tabacum

    Directory of Open Access Journals (Sweden)

    Aldona Rennert

    2015-01-01

    Full Text Available An influence of hydroxyurea (HU on the growth, DNA and RNA contents and protein synthesis in the tobacco tumour tissue culture was studied in comparison with a homologous callus tissue. In conformity with expectations considerable decrease of DNA level in both tissues is a primary effect of HU activity. This results in the growth inhibition and in the secondary metabolic effects; these effects depend not only on the concentration of inhibitor but also on the age of tissue. In spite of some common features the character of these changes shows a distinct differentiation depending on the tissue type. TMs points to specific modifications of the biochemical regulation of growth in a tumour.

  11. Cooperative interplay of let-7 mimic and HuR with MYC RNA.

    Science.gov (United States)

    Gunzburg, Menachem J; Sivakumaran, Andrew; Pendini, Nicole R; Yoon, Je-Hyun; Gorospe, Myriam; Wilce, Matthew C J; Wilce, Jacqueline A

    2015-01-01

    Both RNA-binding proteins (RBP) and miRNA play important roles in the regulation of mRNA expression, often acting together to regulate a target mRNA. In some cases the RBP and miRNA have been reported to act competitively, but in other instances they function cooperatively. Here, we investigated HuR function as an enhancer of let-7-mediated translational repression of c-Myc despite the separation of their binding sites. Using an in vitro system, we determined that a let-7 mimic, consisting of single-stranded (ss)DNA complementary to the let-7 binding site, enhanced the affinity of HuR for a 122-nt MYC RNA encompassing both binding sites. This finding supports the biophysical principle of cooperative binding by an RBP and miRNA purely through interactions at distal mRNA binding sites.

  12. Acute Hepatitis Induced by Chinese Hepatoprotective Herb, Xiao-Chai-Hu-Tang

    Directory of Open Access Journals (Sweden)

    Li-Ming Hsu

    2006-02-01

    Full Text Available Xiao-chai-hu-tang (syo-saiko-to in Japanese is a herbal remedy that has been widely used in China for treatment of respiratory, hepatobiliary, and gastrointestinal diseases, particularly among patients with chronic liver disease. However, its safety has recently been challenged. We, herein, report a Chinese patient with acute hepatitis induced by this herb. A 52-year-old woman presented with weakness, fatigue, and tea-colored urine after continual consumption of the decoction of xiao-chai-hu-tang for 1.5 months. Laboratory studies disclosed acute hepatitis even though all of the viral hepatitis markers were negative. Liver biopsy also revealed a picture of acute hepatocellular hepatitis. The symptoms improved after discontinuing the drug, and liver biochemical tests normalized 2 months later. The case report reminds us of the probable adverse drug reaction of herbs, even in some that are claimed to have hepatoprotective effects.

  13. Breast cancer detection via Hu moment invariant and feedforward neural network

    Science.gov (United States)

    Zhang, Xiaowei; Yang, Jiquan; Nguyen, Elijah

    2018-04-01

    One of eight women can get breast cancer during all her life. This study used Hu moment invariant and feedforward neural network to diagnose breast cancer. With the help of K-fold cross validation, we can test the out-of-sample accuracy of our method. Finally, we found that our methods can improve the accuracy of detecting breast cancer and reduce the difficulty of judging.

  14. Epistemological anarchism of Paul Karl Feyerabend and medical education

    Directory of Open Access Journals (Sweden)

    Andréia Patrícia Gomes

    Full Text Available The thoughts of the philosopher Paul Karl Feyerabend brought important contributions to the debate on Science in the 20th century. Most recently his views about non-existence of a single method for doing science have been employed to rethink science education and propose the use of multiple methods for effective teaching-learning process. This article employs the theoretical framework of the author expressed in the book Against Method, 1977, about the epistemological anarchism and the methodological pluralism and uses it in the contemporary discussion of medical education.

  15. Strangest man the hidden life of Paul Dirac, quantum genius

    CERN Document Server

    Farmelo, Graham

    2009-01-01

    Paul Dirac was among the great scientific geniuses of the modern age. One of the discoverers of quantum mechanics, the most revolutionary theory of the past century, his contributions had a unique insight, eloquence, clarity, and mathematical power. His prediction of antimatter was one of the greatest triumphs in the history of physics. One of Einstein's most admired colleagues, Dirac was in 1933 the youngest theoretician ever to win the Nobel Prize in physics. Dirac's personality is legendary. He was an extraordinarily reserved loner, relentlessly literal-minded and appeared to have no empath

  16. Paul Cefalu. Revisionist Shakespeare: Transitional Ideologies in Texts and Contexts

    Directory of Open Access Journals (Sweden)

    Rainer EMIG

    2006-06-01

    Full Text Available Paul Cefalu, Assistant Professor of English at Lafayette College, offers five essays, three of which have previously appeared in different versions in periodicals, in this stimulating, but also sometimes puzzling and even frustrating book. That he aims for a revision of the core of Shakespearean Studies is already evident in his choice of objects for his analysis: The Tempest, Coriolanus, The Merchant of Venice, King Lear, and Hamlet. Yet “revisionist” is only implicitly applied to Cefalu's o...

  17. Paul Drude's prediction of nonreciprocal mutual inductance for Tesla transformers.

    Science.gov (United States)

    McGuyer, Bart

    2014-01-01

    Inductors, transmission lines, and Tesla transformers have been modeled with lumped-element equivalent circuits for over a century. In a well-known paper from 1904, Paul Drude predicts that the mutual inductance for an unloaded Tesla transformer should be nonreciprocal. This historical curiosity is mostly forgotten today, perhaps because it appears incorrect. However, Drude's prediction is shown to be correct for the conditions treated, demonstrating the importance of constraints in deriving equivalent circuits for distributed systems. The predicted nonreciprocity is not fundamental, but instead is an artifact of the misrepresentation of energy by an equivalent circuit. The application to modern equivalent circuits is discussed.

  18. Paul Ehrlich: the Nobel Prize in physiology or medicine 1908.

    Science.gov (United States)

    Piro, Anna; Tagarelli, Antonio; Tagarelli, Giuseppe; Lagonia, Paolo; Quattrone, Aldo

    2008-01-01

    We wish to commemorate Paul Ehrlich on the centennial of his being awarded the Nobel Prize in Physiology or Medicine in 1908. His studies are now considered as milestones in immunology: the morphology of leukocytes; his side-chain theory where he defined the cellular receptor for first time; and his clarification of the difference between serum therapy and chemotherapy. Ehrlich also invented the first chemotherapeutic drug: compound 606, or Salvarsan. We have used some original documents from the Royal Society of London, where Ehrlich was a fellow, and from Leipzig University, where he took a degree in medicine.

  19. Downregulation of β-Adrenoceptors in Isoproterenol-Induced Cardiac Remodeling through HuR.

    Directory of Open Access Journals (Sweden)

    Qian Yin

    Full Text Available β-adrenergic receptors (β-ARs play an important role in cardiac remodeling, which is the key pathological process in various heart diseases and leads to heart failure. However, the regulation of β-AR expression in remodeling hearts is still unclear. This study aims to clarify the possible mechanisms underlying the regulation of β1- and β2-AR expression in cardiac remodeling. The rat model of cardiac remodeling was established by subcutaneous injection of isoproterenol(ISO at the dose of 0.25 mg·kg(-1·d(-1 for 7 days. We found that the expression of β1- and β2-ARs decreased in the remodeling heart. The mechanisms may include the inhibition of DNA transcription and the increase of mRNA degradation. cAMP-response element binding protein(CREB is a well-known transcription factor of β-AR. However, the expression and activation of CREB was not changed in the remodeling heart. Further, human Antigen-R (HuR, a RNA binding protein, which binds to the 3'-untranslated region of the β-AR mRNA and promotes RNA degradation, was increased in the remodeling model. And in vitro, HuR deficiency reversed the reduction of β-AR mRNA induced by ISO. Therefore, the present findings indicate that HuR, but not CREB, is responsible for the reduction of β-AR expression in ISO induced cardiac remodeling.

  20. HuAc: Human Activity Recognition Using Crowdsourced WiFi Signals and Skeleton Data

    Directory of Open Access Journals (Sweden)

    Linlin Guo

    2018-01-01

    Full Text Available The joint of WiFi-based and vision-based human activity recognition has attracted increasing attention in the human-computer interaction, smart home, and security monitoring fields. We propose HuAc, the combination of WiFi-based and Kinect-based activity recognition system, to sense human activity in an indoor environment with occlusion, weak light, and different perspectives. We first construct a WiFi-based activity recognition dataset named WiAR to provide a benchmark for WiFi-based activity recognition. Then, we design a mechanism of subcarrier selection according to the sensitivity of subcarriers to human activities. Moreover, we optimize the spatial relationship of adjacent skeleton joints and draw out a corresponding relationship between CSI and skeleton-based activity recognition. Finally, we explore the fusion information of CSI and crowdsourced skeleton joints to achieve the robustness of human activity recognition. We implemented HuAc using commercial WiFi devices and evaluated it in three kinds of scenarios. Our results show that HuAc achieves an average accuracy of greater than 93% using WiAR dataset.

  1. Coordination of genomic structure and transcription by the main bacterial nucleoid-associated protein HU

    Science.gov (United States)

    Berger, Michael; Farcas, Anca; Geertz, Marcel; Zhelyazkova, Petya; Brix, Klaudia; Travers, Andrew; Muskhelishvili, Georgi

    2010-01-01

    The histone-like protein HU is a highly abundant DNA architectural protein that is involved in compacting the DNA of the bacterial nucleoid and in regulating the main DNA transactions, including gene transcription. However, the coordination of the genomic structure and function by HU is poorly understood. Here, we address this question by comparing transcript patterns and spatial distributions of RNA polymerase in Escherichia coli wild-type and hupA/B mutant cells. We demonstrate that, in mutant cells, upregulated genes are preferentially clustered in a large chromosomal domain comprising the ribosomal RNA operons organized on both sides of OriC. Furthermore, we show that, in parallel to this transcription asymmetry, mutant cells are also impaired in forming the transcription foci—spatially confined aggregations of RNA polymerase molecules transcribing strong ribosomal RNA operons. Our data thus implicate HU in coordinating the global genomic structure and function by regulating the spatial distribution of RNA polymerase in the nucleoid. PMID:20010798

  2. Don't think about blue elephants! / Paul Hanley ; interv. Alina Lisina

    Index Scriptorium Estoniae

    Hanley, Paul

    2005-01-01

    "Guerrilla marketing'i" (partisani turundus) - hoolikalt kavandatud ja alternatiivseid kanaleid kasutav ebatraditsiooniline turundustegevus - tutvustus. Lisad: Paul Hanley; GM müüdid; 15 Guerrilla turunduse saladust

  3. The inhibition, reactivation and mechanism of VX-, sarin-, fluoro-VX and fluoro-sarin surrogates following their interaction with HuAChE and HuBuChE.

    Science.gov (United States)

    Chao, Chih-Kai; Balasubramanian, Narayanaganesh; Gerdes, John M; Thompson, Charles M

    2018-06-16

    In this study, the mechanisms of HuAChE and HuBChE inhibition by Me-P(O) (OPNP) (OR) [PNP = p-nitrophenyl; R = CH 2 CH 3 , CH 2 CH 2 F, OCH(CH 3 ) 2 , OCH(CH 3 ) (CH 2 F)] representing surrogates and fluoro-surrogates of VX and sarin were studied by in vitro kinetics and mass spectrometry. The in vitro measures showed that the VX- and fluoro-VX surrogates were relatively strong inhibitors of HuAChE and HuBChE (k i  ∼ 10 5 -10 6  M -1 min -1 ) and underwent spontaneous and 2-PAM-mediated reactivation within 30 min. The sarin surrogates were weaker inhibitors of HuAChE and HuBChE (k i  ∼ 10 4 -10 5  M -1 min -1 ), and in general did not undergo spontaneous reactivation, although HuAChE adducts were partially reactivatable at 18 h using 2-PAM. The mechanism of HuAChE and HuBChE inhibition by the surrogates was determined by Q-TOF and MALDI-TOF mass spectral analyses. The surrogate-adducted proteins were trypsin digested and the active site-containing peptide bearing the OP-modified serine identified by Q-TOF as triply- and quadruply-charged ions representing the respective increase in mass of the attached OP moiety. Correspondingly, monoisotopic ions of the tryptic peptides representing the mass increase of the OP-adducted peptide was identified by MALDI-TOF. The mass spectrometry analyses validated the identity of the OP moiety attached to HuAChE or HuBChE as MeP(O) (OR)-O-serine peptides (loss of the PNP leaving group) via mechanisms consistent with those found with chemical warfare agents. MALDI-TOF MS analyses of the VX-modified peptides versus time showed a steady reduction in adduct versus parent peptide (reactivation), whereas the sarin-surrogate-modified peptides remained largely intact over the course of the experiment (24 h). Overall, the presence of a fluorine atom on the surrogate modestly altered the rate constants of inhibition and reactivation, however, the mechanism of inhibition (ejection of PNP group) did not change

  4. Computed tomography imaging for the characterisation of drugs with radiation density measurements and HU spectroscopy.

    Science.gov (United States)

    Sieron, Dominik A; Steib, Moritz; Suter, Dominik; Obmann, Verena C; Huber, Adrian T; Ebner, Lukas; Inderbitzin, Daniel; Christe, Andreas

    2018-01-29

    To investigate the computed tomography (CT) density of frequently administered medications (1) for the better characterisation of substances on abdominal CT, (2) to allow radiologists to narrow down possibilities in the identification of hyperdense material in the bowel and (3) to provide forensic doctors with a tool to identify gastric contents before an autopsy. From the list of the local hospital pharmacy, the 50 most frequently used medications were identified and scanned twice with a 128 row CT scanner (Acquillion, Toshiba, Tokyo, Japan). The protocol comprised two tube voltages of 100 kVp and 120 kVp, with a tube current of 100 mAs, a collimation of 0.5 mm and a slice thickness of 0.5 mm. Two readers were asked to measure the density (in Hounsfield units) and the noise (standard deviation of the Hounsfield units) of each pill in the two scans (100/120 kVp). After 4 weeks, both readers repeated the measurements to test repeatability (intra-rater agreement). The behaviour of each pill in hydrochloric acid (pH 2) was examined and the dissolution time was determined. The most dense pill was Cordarone (7265 HU), and the least was Perenterol (529 HU), with an attenuation that was lower than fat density (standard deviation of pixel density (noise) reflects inhomogeneity of the pharmacological product, varying from 9 to 1592 HU among the different pills (at 120 kVp). The absolute average HU increase per pill when changing to lower voltage was 78 ± 253 HU, with a linear fitting line with a slope of 0.21 as a constant variable in the density spectroscopy. After 4 hours in hydrochloric acid, only six tablets were still intact, including Flagyl and Dafalgan. The intra- and inter-rater agreements for all measurements were nearly perfect, with a correlation coefficient r of ≥0.99 (p <0.0001). Our data suggest that measuring the attenuation of drugs on CT images, including the homogeneity, and applying CT spectroscopy can narrow down possible identities of the most

  5. Paul W. Kruse (1927-2012), In Memoriam

    Science.gov (United States)

    Reine, Marion B.; Norton, Paul R.; Stelzer, Ernie L.

    2013-06-01

    During his distinguished 37-year career as a research physicist at the Honeywell Research Center in Minneapolis, Minnesota, Dr. Paul W. Kruse (1927-2012) played leadership roles in two disruptive infrared detector technologies, the narrow-gap semiconductor alloy HgCdTe and the silicon CMOS-based microbolometer array, both of which revolutionized the worldwide infrared detector industry. He served on numerous government advisory boards and panels, including the Army Scientific Advisory Panel and the Army Science Board, for which he received the Outstanding Civilian Service Medal. After retiring for Honeywell in 1993, he remained active in the infrared detector field in several roles: as a successful small-business entrepreneur, as an author of two books, and as a SPIE lecturer. His books, papers and lectures have educated new generations of workers in the infrared detector industry. His career, a model for industrial research physicists, has had major and permanent impacts on the worldwide infrared detector industry. This paper is a summary of the career of Paul W. Kruse, as well as a tribute to that career and its lasting legacy.

  6. The cytoskeletal inhibitors latrunculin A and blebbistatin exert antitumorigenic properties in human hepatocellular carcinoma cells by interfering with intracellular HuR trafficking

    Energy Technology Data Exchange (ETDEWEB)

    Doller, Anke; Badawi, Amel [Pharmazentrum Frankfurt/ZAFES, Klinikum der Goethe-Universität Frankfurt, Frankfurt/Main (Germany); Schmid, Tobias; Brauß, Thilo [Institut für Biochemie I (Pathobiochemie), Klinikum der Goethe-Universität Frankfurt, Frankfurt/Main (Germany); Pleli, Thomas [Medizinische Klinik 1, Schwerpunkt Gastroenterologie und Hepatologie, Klinikum der Goethe-Universität Frankfurt, Frankfurt/Main (Germany); Meyer zu Heringdorf, Dagmar [Pharmazentrum Frankfurt/ZAFES, Klinikum der Goethe-Universität Frankfurt, Frankfurt/Main (Germany); Piiper, Albrecht [Medizinische Klinik 1, Schwerpunkt Gastroenterologie und Hepatologie, Klinikum der Goethe-Universität Frankfurt, Frankfurt/Main (Germany); Pfeilschifter, Josef [Pharmazentrum Frankfurt/ZAFES, Klinikum der Goethe-Universität Frankfurt, Frankfurt/Main (Germany); Eberhardt, Wolfgang, E-mail: w.eberhardt@em.uni-frankfurt.de [Pharmazentrum Frankfurt/ZAFES, Klinikum der Goethe-Universität Frankfurt, Frankfurt/Main (Germany)

    2015-01-01

    The impact of the RNA-binding protein HuR for the post-transcriptional deregulation of tumor-relevant genes is well established. Despite of elevations in HuR expression levels, an increase in cytoplasmic HuR abundance in many cases correlates with a high grade of malignancy. Here, we demonstrated that administration of the actin-depolymerizing macrolide latrunculin A, or blebbistatin, an inhibitor of myosin II ATPase activity, caused a dose- and time-dependent reduction in the high cytoplasmic HuR content of HepG2 and Huh7 hepatocellular carcinoma (HCC) cells. Subcellular fractionation revealed that in addition, both inhibitors strongly attenuated cytoskeletal and membrane-bound HuR abundance and conversely increased the HuR amount in nuclear cell fractions. Concomitant with changes in intracellular HuR localization, both cytoskeletal inhibitors markedly decreased the half-lives of cyclooxygenase-2 (COX-2), cyclin A and cyclin D{sub 1} encoding mRNAs resulting in a significant reduction in their expression levels in HepG2 cells. Importantly, a similar reduction in the expression of these HuR targets was achieved by a RNA interference (RNAi)-mediated knockdown of either HuR or nonmuscle myoin IIA. Using polysomal fractionation, we further demonstrate that the decrease in cytoplasmic HuR by latrunculin A or blebbistatin is accompanied by a marked change in the allocation of HuR and its mRNA cargo from polysomes to ribonucleoprotein (RNP) particles. Functionally, the basal migration and prostaglandin E{sub 2} synthesis are similarly impaired in inhibitor-treated and stable HuR-knockdown HepG2 cells. Our data demonstrate that interfering with the actomyosin-dependent HuR trafficking may comprise a valid therapeutic option for antagonizing pathologic posttranscriptional gene expression by HuR and furthermore emphasize the potential benefit of HuR inhibitory strategies for treatment of HCC. - Highlights: • We tested the effects of latrunculin A and blebbistatin on

  7. The cytoskeletal inhibitors latrunculin A and blebbistatin exert antitumorigenic properties in human hepatocellular carcinoma cells by interfering with intracellular HuR trafficking

    International Nuclear Information System (INIS)

    Doller, Anke; Badawi, Amel; Schmid, Tobias; Brauß, Thilo; Pleli, Thomas; Meyer zu Heringdorf, Dagmar; Piiper, Albrecht; Pfeilschifter, Josef; Eberhardt, Wolfgang

    2015-01-01

    The impact of the RNA-binding protein HuR for the post-transcriptional deregulation of tumor-relevant genes is well established. Despite of elevations in HuR expression levels, an increase in cytoplasmic HuR abundance in many cases correlates with a high grade of malignancy. Here, we demonstrated that administration of the actin-depolymerizing macrolide latrunculin A, or blebbistatin, an inhibitor of myosin II ATPase activity, caused a dose- and time-dependent reduction in the high cytoplasmic HuR content of HepG2 and Huh7 hepatocellular carcinoma (HCC) cells. Subcellular fractionation revealed that in addition, both inhibitors strongly attenuated cytoskeletal and membrane-bound HuR abundance and conversely increased the HuR amount in nuclear cell fractions. Concomitant with changes in intracellular HuR localization, both cytoskeletal inhibitors markedly decreased the half-lives of cyclooxygenase-2 (COX-2), cyclin A and cyclin D 1 encoding mRNAs resulting in a significant reduction in their expression levels in HepG2 cells. Importantly, a similar reduction in the expression of these HuR targets was achieved by a RNA interference (RNAi)-mediated knockdown of either HuR or nonmuscle myoin IIA. Using polysomal fractionation, we further demonstrate that the decrease in cytoplasmic HuR by latrunculin A or blebbistatin is accompanied by a marked change in the allocation of HuR and its mRNA cargo from polysomes to ribonucleoprotein (RNP) particles. Functionally, the basal migration and prostaglandin E 2 synthesis are similarly impaired in inhibitor-treated and stable HuR-knockdown HepG2 cells. Our data demonstrate that interfering with the actomyosin-dependent HuR trafficking may comprise a valid therapeutic option for antagonizing pathologic posttranscriptional gene expression by HuR and furthermore emphasize the potential benefit of HuR inhibitory strategies for treatment of HCC. - Highlights: • We tested the effects of latrunculin A and blebbistatin on different Hu

  8. Innate Immune Activation Can Trigger Experimental Spondyloarthritis in HLA-B27/Huβ2m Transgenic Rats

    NARCIS (Netherlands)

    van Tok, Melissa N.; Satumtira, Nimman; Dorris, Martha; Pots, Desirée; Slobodin, Gleb; van de Sande, Marleen G.; Taurog, Joel D.; Baeten, Dominique L.; van Duivenvoorde, Leonie M.

    2017-01-01

    Spondyloarthritis (SpA) does not display the typical features of auto-immune disease. Despite the strong association with MHC class I, CD8(+) T cells are not required for disease induction in the HLA-B27/Huβ2m transgenic rats. We used Lewis HLA-B27/Huβ2m transgenic rats [21-3 × 283-2]F1,

  9. HuR binds to a single site on the C/EBPβ mRNA of 3T3-L1 adipocytes

    International Nuclear Information System (INIS)

    Jones, Heath; Carver, Melinda; Pekala, Phillip H.

    2007-01-01

    HuR is a ligand for nuclear mRNAs containing adenylate-uridylate rich elements in the 3'-untranslated region. Once bound to the mRNA, HuR is recognized by adapter proteins which then facilitate nuclear export of the complex. In the cytosol HuR is thought to function to control stability and translation of its ligand message. In the 3T3-L1 cells HuR is constitutively expressed and localized predominantly to the nucleus in the preadipocytes. However within 30 min of exposure to the differentiation stimulus, the HuR content in the cytosol increases consistent with HuR regulating the availability of relevant mRNAs for translation. Using in vitro RNA gel shifts, we have demonstrated that the C/EBPβ message is a ligand for HuR and that the single binding site is an adenylate-uridylate rich element in the 3'-untranslated region

  10. A kinetic analysis of kappa-opioid agonist binding using the selective radioligand (/sup 3/H)U69593

    Energy Technology Data Exchange (ETDEWEB)

    Smith, J.A.; Hunter, J.C.; Hill, R.G.; Hughes, J.

    1989-07-01

    The interaction of the nonselective opioid ligand (3H)bremazocine and of the kappa-opioid (3H)U69593 with the kappa-receptor was investigated in guinea-pig cortical membranes. Each radioligand bound to a single population of high-affinity sites, although (3H)U69593 apparently recognised only 70% of those sites labelled by (3H)bremazocine. Naloxone and the kappa-selective ligands U69593 and PD117302 exhibited full inhibition of the binding of both radioligands. Kinetic analysis demonstrated biphasic rates of association and dissociation for both (3H)bremazocine and (3H)U69593. Detailed analysis of the binding of (3H)U69593 revealed that the fast rate of association was dependent on radioligand concentration, in contrast to the slow rate, which was independent of ligand concentration. Guanylyl-5'-imidodiphosphate (GppNHp) inhibited binding of (3H)U69593; saturation analysis demonstrated that the inhibitory effects of GppNHp resulted in a decrease in affinity without any significant change in binding capacity. GppNHp attenuated the formation of the slow component of (3H)U69593 binding, while accelerating the fast component. The data are consistent with the formation of a high-affinity complex between the kappa-receptor and a guanine nucleotide binding protein. Guanine nucleotides promote the dissociation of this ternary complex and the stabilisation of a lower-affinity state of the receptor.

  11. [Fatal diseases and "imaginary" suffering. "Hypochondria" and "consumption" in the correspondence between Jean Paul and Johann Bernhard Hermann, with a perspective on Jean Paul's literature and aesthetics].

    Science.gov (United States)

    Meier, Monika

    2007-01-01

    The German writerJean Paul (Johann Paul Friedrich Richter, 1763-1825) and his friendJohann Bernhard Hermann (1761-1790) became acquainted with the thoughts of late Enlightenment at the University of Leipzig. They particularly appreciated the anthropology of Ernst Platner, who taught philosophy and aesthetics as well as medicine. Their confidential correspondence contains reflections on their respective situation and well being. Both write about feeling ill and label their illness "hypochondria". In the course of the correspondence Jean Paul's understanding of hypochondria evolves from an illness of the entrails as he follows Hermann, who supports the modern concept of hypochondria as an illness of the nerves. Two important themes from this correspondence recur in Jean Paul's novels and tales: firstly, his way of expressing comfort is related to his aesthetics, and secondly, the satirical way of portraying at least certain aspects of illness as imaginary reappears in his first successful novel "The Invisible Lodge" (1793).

  12. Vahur-Paul Põldma - tõlkis raamatu, lavastas etenduse, ise mängib ja üksi / Vahur-Paul Põldma ; interv. Triin Tael

    Index Scriptorium Estoniae

    Põldma, Vahur-Paul

    2008-01-01

    Alessandro Baricco teos "Novecento", mida Vahur-Paul Põldma mängib Uue Vana Teatri nime all ühemeheetendusena. Lisaks tutvustus "Kes on Alessandro Baricco?" ja "Vahur-Pauli salaminevik : töö lasteaiakasvatajana"

  13. Domain-specific phosphomimetic mutation allows dissection of different protein kinase C (PKC) isotype-triggered activities of the RNA binding protein HuR.

    Science.gov (United States)

    Schulz, Sebastian; Doller, Anke; Pendini, Nicole R; Wilce, Jacqueline A; Pfeilschifter, Josef; Eberhardt, Wolfgang

    2013-12-01

    The ubiquitous mRNA binding protein human antigen R (HuR) participates in the post-transcriptional regulation of many AU-rich element (ARE)-bearing mRNAs. Previously, by using in vitro kinase assay, we have identified serines (Ser) 158, 221 and 318 as targets of protein kinase C (PKC)-triggered phosphorylation. In this study, we tested whether GFP- or GST-tagged HuR constructs bearing a phosphomimetic Ser (S)-to-Asp (D) substitution at the different PKC target sites, would affect different HuR functions including HuR nucleo-cytoplasmic redistribution and binding to different types of ARE-containing mRNAs. The phosphomimetic GFP-tagged HuR protein bearing a phosphomimetic substitution in the hinge region of HuR (HuR-S221D) showed an increased cytoplasmic abundance when compared to wild-type HuR. Conversely, data from in vitro kinase assay and electrophoretic mobility shift assay (EMSA), implicates that phosphorylation at Ser 221 is not relevant for mRNA binding of HuR. Quantification of in vitro binding affinities of GST-tagged wild-type HuR and corresponding HuR proteins bearing a phosphomimetic substitution in either RRM2 (HuR-S158D) or in RRM3 (HuR-S318D) by microscale thermophoresis (MST) indicates a specific binding of wild-type HuR to type I, II or type III-ARE-oligonucleotides in the high nanomolar range. Interestingly, phosphomimetic mutation at position 158 or 318 had a negative influence on HuR binding to type I- and type II-ARE-mRNAs whereas it significantly enhanced HuR affinity to a type III-ARE substrate. Our data suggest that differential phosphorylation of HuR by PKCs at different HuR domains coordinates subcellular HuR distribution and leads to a preferential binding to U-rich bearing target mRNA. © 2013.

  14. Paule Marshall and the search for the African diaspora

    Directory of Open Access Journals (Sweden)

    Simon Gikandi

    1999-01-01

    Full Text Available [First paragraph] The Fiction of Paule Marshall: Reconstructions of History, Culture, and Gender. DOROTHY HAMER DENNISTON. Knoxville: University of Tennesee Press, 1995. xxii + 187 pp. (Paper US$ 15.00 Toward Wholeness in Paule Marshall's Fiction. JOYCE PETTIS. Charlottesville: University of Virginia Press, 1995. xi + 173 pp. (Cloth US$ 29.50 Black and Female: Essays on Writings by Black Women in the Diaspora. BRITA LINDBERG-SEYERSTED. Oslo: Scandinavian University Press, 1994. 164 pp. (Paper n.p. Literary history has not been very kind to Paule Marshall. Even in the early 1980s when literature produced by African-American women was gaining prominence among general readers and drawing the attention of critics, Marshall was still considered to be an enigmatic literary figure, somehow important in the canon but not one of its trend setters. As Mary Helen Washington observed in an influential afterword to Brown Girl, Brownstones, although Marshall had been publishing novels and short stories since the early 1950s, and was indeed the key link between African-American writers of the 1940s and those of the 1960s, she was just being "discovered" in the 1980s. While there has always been a small group of scholars, most notably Kamau Brathwaite, who have called attention to the indispensable role Marshall has played in the shaping of the literary canon of the African Diaspora, and of her profound understanding of the issues that have affected the complex formation and survival of African-derived cultures in the New World, many critics have found it difficult to locate her within the American, African-American, and Caribbean traditions that are the sources of her imagination and the subject of her major works. Marshall has embraced all these cultures in more profound ways than her more famous contemporaries have, but she has not gotten the accolades that have gone to lesser writers like Alice Walker. It is indeed one of the greatest injustices of

  15. Contesting history and identity formation in Paul and in South Africa ...

    African Journals Online (AJOL)

    This study compares dynamics in the contestation of history and identity between Paul to post-1994 white Afrikaners in South Africa. In reference to Paul, I am interested in how the followers of the nascent Hellenistic Gentile Christian movement claimed legitimacy as the true Jews, usurping the monopoly of the identity 'true ...

  16. On social justice: Comparing Paul with Plato, Aristotle and the Stoics

    African Journals Online (AJOL)

    p1243322

    If Paul tried to establish egalitarian and sharing Christian communities under ... study on Paul for the debate on universal human values – except to suggest ... challenge until, at least for many, Caesar's apotheosis meant not ... just the promise, but the start of the world's salvation, redemption, ..... All will be on a par together.

  17. The value of children in the context of the family in Java / by Paul A. Meyer

    Trove (Australia)

    Meyer, Paul A

    1987-01-01

    ... The value of children in the context of the family in Java [microform] / by Paul A. Meyer. The value of children in the context of the family in Java by Paul A. Meyer. The value of children in the context of the family in Java ...

  18. 77 FR 68149 - Karen Paul Holley, M.D.; Decision and Order

    Science.gov (United States)

    2012-11-15

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 12-51] Karen Paul Holley, M.D... revoke the DEA Certificate of Registration (COR), Number BH8988339, of Karen Paul Holley, M.D....D., 74 FR 17528, 174529 (2009); John B. Freitas, D.O., 74 FR 17524, 17525 (2009); Roger A. Rodriguez...

  19. 77 FR 41168 - Marine Mammals; Subsistence Taking of Northern Fur Seals; St. Paul Island

    Science.gov (United States)

    2012-07-12

    ... Administrative Procedure Act (APA). The Pribilof Island Community of St. Paul Island, Aleut Community of St. Paul... comment on from the resulting list and click on the ``Submit a Comment'' icon on the right of that line... Adobe PDF file formats only. Information related to the request for rulemaking is available on the...

  20. The present day relevance of Paul's advice to the family in the ...

    African Journals Online (AJOL)

    Many people and organizations have made several efforts to improve and enhance the survival of the family. An example is the advice of Saint Paul, the Apostle to the Christian family in Ephesians 5:22-25 and 6:1-9. This paper examines this advice and its relevance to the society today. Key Words: Paul, Apostle; Advice; ...

  1. 76 FR 73666 - Notice of Inventory Completion: Paul H. Karshner Memorial Museum, Puyallup, WA

    Science.gov (United States)

    2011-11-29

    ..., 2011. ADDRESSES: Brian Fox, Director of Instructional Leadership, Puyallup School District, Paul H... American. Pursuant to 25 U.S.C. 3001(2), a relationship of shared group identity cannot be reasonably... criteria in 43 CFR 10.11(c)(1) should contact Brian Fox, Director of Instructional Leadership, Paul H...

  2. Kunstnikuraamatud / Paul Kuimet, Dénes Kalev Farkas, Laura Kuusk ; intervjueerinud Laura Kuusk, Kristel Schwede

    Index Scriptorium Estoniae

    Kuimet, Paul, 1984-

    2016-01-01

    Paul Kuimet, Dénes Kalev Farkas ja Laura Kuusk räägivad, kuidas valmisid nende kunstnikuraamatud ja mis oli projekti tõukejõuks. Paul Kuimeti fotoraamat "In Vicinity", Dénes Kalev Farkasi raamatud "Evident in Advance" ja "Credo", Laura Kuuse raamat "Pop-up-book"

  3. 78 FR 76143 - Proposed CERCLA Settlement Relating to the Paul's Tank Cleaning Service Superfund Site...

    Science.gov (United States)

    2013-12-16

    ... Paul's Tank Cleaning Service Superfund Site, Burlington County, New Jersey AGENCY: Environmental.... (``Settling Party''). The Settling Party is a potentially responsible party, pursuant to Section 107(a) of CERCLA, and thus is potentially liable for response costs incurred at or in connection Paul's Tank...

  4. Paul Voosen Receives 2013 David Perlman Award for Excellence in Science Journalism—News: Citation

    Science.gov (United States)

    Zaneski, Cyril T.

    2014-01-01

    It's my pleasure to nominate Paul Voosen, the former science reporter for Greenwire, for the David Perlman award. Last November, as Superstorm Sandy pounded the East Coast of the United States, Paul found himself stranded for several days in Miami, mourning a recently deceased family member.

  5. Paul Dundes Wolfowitz. Aukus sokkidega pistrik nõelub mainet / Arko Olesk

    Index Scriptorium Estoniae

    Olesk, Arko, 1981-

    2007-01-01

    Maailmapanga president Paul Wolfowitz teatas pressikonverentsil, et soovib tööd jätkata. Paul Wolfowitzi karjäärist, päritolust, eraelust ja usalduse kaotamisest korruptsioonihõngulise loo pärast oma sõbratarile Shaha Ali Rizale palgatõusu nõudmisel

  6. 'Hu Hong' (bad thing): parental perceptions of teenagers' sexuality in urban Vietnam.

    Science.gov (United States)

    Do, Lan Anh Thi; Boonmongkon, Pimpawun; Paek, Seung Chun; Guadamuz, Thomas E

    2017-02-28

    Teenagers under 18 years old in Vietnam are considered as minors who usually lack the autonomy to make decisions. They are also sometimes viewed as contributors to social evils including crime, violence and substance use. Moreover, most Vietnamese teenagers have unsafe sex before marriage. The objective of this study is to explore the parental perceptions relating to their teenagers' sexuality, particularly the social and cultural forces, that may hinder access to sexuality information. Guided by a Community Advisory Board (CAB), this qualitative study uses four focus group discussions (FGDs) consisting of 12 mothers and 12 fathers, as well as twelve individual in-depth interviews (IDIs) with a diverse sample of parents of teens in Ho Chi Minh City (HCMC), Vietnam. Content and discourse analysis were conducted, based on Foucauldian concepts. Four themes emerged: 1) Meanings of sexuality and sexuality education, 2) Early sexual intercourse destroys teenagers' future, 3) Teenagers are not hu hong (spoil/bad thing), are innocent and virgin, and 4) Policing and controlling of sexual intercourse among teens. Parents did not view their teenage children as sexual beings; those who are sexual are considered hu hong. Parents believed that teens need to be policed and controlled to prevent them from becoming hu hong, particularly girls. Controlling of sexuality information by parents was therefore common in HCMC, but differed by gender and educational levels of parents. For example, fathers more than mothers were not comfortable teaching their teenage children about sex and sexuality. Parents with higher education police their teenage children's usage of the Internet and social media, while parents with lower education control who can be friends with their teenage children. Vietnamese parents in general have negative views of sex and sexuality education for their teenage children. Recognizing that many Vietnamese teenagers have unsafe sex before marriage, parents need to

  7. Effects of weaning age on growth, nutrient digestibility and metabolism, and serum parameters in Hu lambs

    Directory of Open Access Journals (Sweden)

    Jianmin Chai

    2015-12-01

    Full Text Available This study was conducted to investigate the effect of weaning age on growth performance, nutrient digestion and metabolism, and serological indicators, and to obtain an optimal weaning age in Hu lambs. Forty-eight newborn Hu lambs (birth weight, 2.53 ± 0.14 kg were randomly divided into 4 groups. The lambs in control group (ER suckled their dams. The lambs in other three experimental groups were weaned on milk replacer at 10, 20, and 30 days of age (EW10, EW20, and EW30 groups, respectively. The results were as follows: 1 lambs in EW10 and EW30 groups had a lower (P  0.05 among groups; however, the apparent digestibility and deposition of calcium in early weaned lambs were lower (P < 0.05 than those in ewe-reared lambs. 4 The albumin content in EW30 group was lower (P < 0.05 than that in ER group; the globulin content in EW30 group was higher (P < 0.05 than that in other groups; the content of serum insulin-like growth factor-Ⅰ in weaned lambs tended to increase compared with lambs in ER group. Finally, the growth rate of lambs decreased within 10 days post-weaning, but early weaning boosted creep feed intake, leading to better growth and health later in life. The Hu lambs can be weaned on milk replacer and creep feed at 10 days of age.

  8. Paul Scherrer Institut Annual Report 2001: General Volume

    Energy Technology Data Exchange (ETDEWEB)

    Salzmann, M. (ed.)

    2002-07-01

    The Paul Scherrer Institute is a centre for multidisciplinary research in the natural and engineering sciences. It collaborates closely with universities, other research institutions, technical colleges, and industry, both in Switzerland and abroad. It is the largest research institute in Switzerland, with about 1'200 members of staff. Its particular areas of specialisation are solid-state research and material sciences, elementary particle physics and astrophysics, biology and medicine, and energy and environmental research. This annual report presents an overview of the work performed by the PSI research departments including information on new developments connected with the various accelerators and on the status of the Swiss Light Source project (SLS). Details on the organizational and financial structure of the Institute are also provided.

  9. Paul Scherrer Institut Annual Report 2000: General Volume

    Energy Technology Data Exchange (ETDEWEB)

    Salzmann, M [ed.

    2001-07-01

    The Paul Scherrer Institute is a centre for multidisciplinary research in the natural and engineering sciences. It collaborates closely with universities, other research institutions, technical colleges, and industry, both in Switzerland and abroad. It is the largest research institute in Switzerland, with about 1'200 members of staff. Its particular areas of specialisation are solid-state research and material sciences, elementary particle physics and astrophysics, biology and medicine, and energy and environmental research. This annual report presents an overview of the work performed by the PSI research departments including information on new developments connected with the various accelerators and on the status of the Swiss Light Source project (SLS). Details on the organizational and financial structure of the Institute are also provided.

  10. Archival approaches in the work of Paul Otlet

    Directory of Open Access Journals (Sweden)

    Leomar José Montilla Peña

    2015-02-01

    Full Text Available We present a bibliometric study of the Treaty of Documentation of Paul Otlet where the goal was to analyze approaches the archival area registered on it. For this study, used the descriptive words method and the associated words method. We applied a longitudinal statistical sampling for periods 1898 to 1933, because he published the first three scientists manuals the classical Archives. The results revealed that there is a total of 10 references related to the archives, the author being Otlet else mentioned, it has more citations and references on this area. The topics most frequently used by Otlet on archival science for discursive reasoning were: methods of organization and administrative documents. The analysis finds that archival approaches registered in the Treaty of Documentation have centrality and low density.

  11. The strangest man. The hidden life of Paul Dirac

    International Nuclear Information System (INIS)

    Farmelo, Graham

    2016-01-01

    The Strangest Man is the Costa Biography Award-winning account of Paul Dirac, the famous physicist sometimes called the British Einstein. He was one of the leading pioneers of the greatest revolution in twentieth-century science: quantum mechanics. The youngest theoretician ever to win the Nobel Prize for Physics, he was also pathologically reticent, strangely literal-minded and legendarily unable to communicate or empathize. Through his greatest period of productivity, his postcards home contained only remarks about the weather. Based on a previously undiscovered archive of family papers, Graham Farmelo celebrates Dirac's massive scientific achievement while drawing a compassionate portrait of his life and work. Farmelo shows a man who, while hopelessly socially inept, could manage to love and sustain close friendship. The Strangest Man is an extraordinary and moving human story, as well as a study of one of the most exciting times in scientific history.

  12. Epistemologi Anarkhis Paul Feyerabend dan Implikasinya terhadap Pemikiran Islam

    Directory of Open Access Journals (Sweden)

    Abdul Aziz Faradi

    2014-11-01

    Full Text Available Nowadays, Islamic thought is trapped on the stagnancy of ideas. Such condition happens because the function of Islam changes, from an instrument for freedom to a rigid system of ideology. The similar pattern of change identified by Feyerabend also exists in the modern science. The similarity of the pattern inspired the writer to elaborate the concept of anarchy epistemology of Paul Feyerabend and its implication to the Islamic thought. This article uses philosophical hermeneutic  approach by Gadamer in investigating meaningful sense of Feyerabend thought. The conclusion of the study ends up with the importance of returning Islamic thought to the pluralistic environment  because Islam itself was not burn in a single thought but at least there are three epistemic patrons; Bayani, Burhani, and ‘Irfani.

  13. The rise of western rationalism: Paul Feyerabend's story.

    Science.gov (United States)

    Preston, John

    2016-06-01

    I summarize certain aspects of Paul Feyerabend's account of the development of Western rationalism, show the ways in which that account is supposed to run up against an alternative, that of Karl Popper, and then try to give a preliminary comparison of the two. My interest is primarily in whether what Feyerabend called his 'story' constitutes a possible history of our epistemic concepts and their trajectory. I express some grave reservations about that story, and about Feyerabend's framework, finding Popper's views less problematic here. However, I also suggest that one important aspect of Feyerabend's material, his treatment of religious belief, can be given an interpretation which makes it tenable, and perhaps preferable to a Popperian approach. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. Historical antecedents to the philosophy of Paul Feyerabend.

    Science.gov (United States)

    Munévar, Gonzalo

    2016-06-01

    Paul Feyerabend has been considered a very radical philosopher of science for proposing that we may advance hypotheses contrary to well-confirmed experimental results, that observations make theoretical assumptions, that all methodological rules have exceptions, that ordinary citizens may challenge the judgment of experts, and that human happiness should be a key value for science. As radical as these theses may sound, they all have historical antecedents. In defending the Copernican view, Galileo exemplified the first two; Mill, Aristotle and Machiavelli all argued for pluralism; Aristotle gave commonsense reasons for why ordinary citizens may be able to judge the work of experts; and a combination of Plato's and Aristotle's views can offer strong support for the connection between science and happiness. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Paul Scherrer Institut Annual Report 2001: General Volume

    Energy Technology Data Exchange (ETDEWEB)

    Salzmann, M [ed.

    2002-07-01

    The Paul Scherrer Institute is a centre for multidisciplinary research in the natural and engineering sciences. It collaborates closely with universities, other research institutions, technical colleges, and industry, both in Switzerland and abroad. It is the largest research institute in Switzerland, with about 1'200 members of staff. Its particular areas of specialisation are solid-state research and material sciences, elementary particle physics and astrophysics, biology and medicine, and energy and environmental research. This annual report presents an overview of the work performed by the PSI research departments including information on new developments connected with the various accelerators and on the status of the Swiss Light Source project (SLS). Details on the organizational and financial structure of the Institute are also provided.

  16. Paul Scherrer Institut Annual Report 2001: General Volume

    International Nuclear Information System (INIS)

    Salzmann, M.

    2002-01-01

    The Paul Scherrer Institute is a centre for multidisciplinary research in the natural and engineering sciences. It collaborates closely with universities, other research institutions, technical colleges, and industry, both in Switzerland and abroad. It is the largest research institute in Switzerland, with about 1'200 members of staff. Its particular areas of specialisation are solid-state research and material sciences, elementary particle physics and astrophysics, biology and medicine, and energy and environmental research. This annual report presents an overview of the work performed by the PSI research departments including information on new developments connected with the various accelerators and on the status of the Swiss Light Source project (SLS). Details on the organizational and financial structure of the Institute are also provided

  17. Paul Celan in Translation: "Du sei wie du"

    Directory of Open Access Journals (Sweden)

    John Felstiner

    1983-09-01

    Full Text Available Translating the lyric poetry of Paul Celan, especially his later poems, carries not only the endemic challenge and difficulty of any verse translation, but the added incentive of doing justice to a writer whose whole recourse after the Holocaust—whose sanctuary, if he was to have any at all—he sought in language itself, specifically in the Muttersprache , the mother tongue that was as well the tongue of those who murdered his mother and father. This essay exposes a process of translating "Du sei wie du" (1970, which perhaps more than any other poem by Celan, at once solicits and defies translation, moving as it does from modern to medieval German, and closing with Hebrew words from Isaiah— a messianic imperative that shows Celan verging as ever on his Jewish identity.

  18. EL DESARROLLO DEL CONCEPTO DE TESTIMONIO EN PAUL RICOEUR

    Directory of Open Access Journals (Sweden)

    Esteban Lythgoe

    2008-01-01

    Full Text Available El objetivo del presente artículo consiste en sostener que ha habido una evolución en el concepto de testimonio de Paul Ricoeur y que incluso su primera definición jurídica se diferencia de otras de la misma raíz. Para establecer este último punto se compara su definición con de C.A.J. Coady. Se intentará dar cuenta de los motivos, implicaciones y limitaciones de sus diferencias. Seguidamente, se afirma que en La memoria, la historia, el olvido el filósofo abandona el concepto jurídico de testimonio, caracterizado como una declaración enmarcada en un debate, para inclinarse por otro que lo define como una institución natural dialógica. Nuestra hipótesis es que dicho cambio fue debido no a causas fenoménicas sino contextuales.

  19. Baring the soul: Paul Bindrim, Abraham Maslow and 'nude psychotherapy'.

    Science.gov (United States)

    Nicholson, Ian

    2007-01-01

    Nude psychotherapy is one of the most flamboyant therapeutic techniques ever developed in American psychology. Largely forgotten today, the therapy was an academic and popular sensation upon its introduction in 1967. Developed by psychologist Paul Bindrim, the therapy promised to guide clients to their authentic selves through the systematic removal of clothing. This paper explores the intellectual, cultural and ethical context of nude therapy and its significance as a form of unchurched spirituality. Although nude therapy has an indisputable tabloid character, it is also rooted in a long-standing academic search for authenticity and ultimate meaning through science. Bindrim's career demonstrates the historically long-standing interweaving of spirituality and science within American psychology while simultaneously highlighting the field's extraordinary capacity for adaptive reinvention.

  20. Paul Scherrer Institut Annual Report 2000: General Volume

    International Nuclear Information System (INIS)

    Salzmann, M.

    2001-01-01

    The Paul Scherrer Institute is a centre for multidisciplinary research in the natural and engineering sciences. It collaborates closely with universities, other research institutions, technical colleges, and industry, both in Switzerland and abroad. It is the largest research institute in Switzerland, with about 1'200 members of staff. Its particular areas of specialisation are solid-state research and material sciences, elementary particle physics and astrophysics, biology and medicine, and energy and environmental research. This annual report presents an overview of the work performed by the PSI research departments including information on new developments connected with the various accelerators and on the status of the Swiss Light Source project (SLS). Details on the organizational and financial structure of the Institute are also provided

  1. Paul Scherrer Institut Annual Report 1999: General Volume

    International Nuclear Information System (INIS)

    Salzmann, M.

    2000-01-01

    The Paul Scherrer Institute is a centre for multidisciplinary research in the natural and engineering sciences. It collaborates closely with universities, other research institutions, technical colleges, and industry, both in Switzerland and abroad. It is the largest research institute in Switzerland, with about 1'200 members of staff. Its particular areas of specialisation are solid-state research and material sciences, elementary particle physics and astrophysics, biology and medicine, and energy and environmental research. This annual report presents an overview of the work performed by the PSI research departments including information on new developments connected with the various accelerators and on the status of the Swiss Light Source project (SLS). Details on the organizational and financial structure of the Institute are also provided

  2. Paul Scherrer Institut Annual Report 1999: General Volume

    Energy Technology Data Exchange (ETDEWEB)

    Salzmann, M [ed.

    2000-07-01

    The Paul Scherrer Institute is a centre for multidisciplinary research in the natural and engineering sciences. It collaborates closely with universities, other research institutions, technical colleges, and industry, both in Switzerland and abroad. It is the largest research institute in Switzerland, with about 1'200 members of staff. Its particular areas of specialisation are solid-state research and material sciences, elementary particle physics and astrophysics, biology and medicine, and energy and environmental research. This annual report presents an overview of the work performed by the PSI research departments including information on new developments connected with the various accelerators and on the status of the Swiss Light Source project (SLS). Details on the organizational and financial structure of the Institute are also provided.

  3. Paul Scherrer Institut Annual Report 1999: General Volume

    Energy Technology Data Exchange (ETDEWEB)

    Salzmann, M. [ed.

    2000-07-01

    The Paul Scherrer Institute is a centre for multidisciplinary research in the natural and engineering sciences. It collaborates closely with universities, other research institutions, technical colleges, and industry, both in Switzerland and abroad. It is the largest research institute in Switzerland, with about 1'200 members of staff. Its particular areas of specialisation are solid-state research and material sciences, elementary particle physics and astrophysics, biology and medicine, and energy and environmental research. This annual report presents an overview of the work performed by the PSI research departments including information on new developments connected with the various accelerators and on the status of the Swiss Light Source project (SLS). Details on the organizational and financial structure of the Institute are also provided.

  4. Paul Scherrer Institut Annual Report 2000: General Volume

    Energy Technology Data Exchange (ETDEWEB)

    Salzmann, M. [ed.

    2001-07-01

    The Paul Scherrer Institute is a centre for multidisciplinary research in the natural and engineering sciences. It collaborates closely with universities, other research institutions, technical colleges, and industry, both in Switzerland and abroad. It is the largest research institute in Switzerland, with about 1'200 members of staff. Its particular areas of specialisation are solid-state research and material sciences, elementary particle physics and astrophysics, biology and medicine, and energy and environmental research. This annual report presents an overview of the work performed by the PSI research departments including information on new developments connected with the various accelerators and on the status of the Swiss Light Source project (SLS). Details on the organizational and financial structure of the Institute are also provided.

  5. Église Saint-Pierre-Saint-Paul, Appoigny (Yonne

    Directory of Open Access Journals (Sweden)

    Fabrice Henrion

    2009-09-01

    Full Text Available L’église Saint-Pierre-Saint-Paul d’Appoigny témoigne d’un important chantier du début du XIIIe siècle , mais les sources permettent d’envisager la présence d’un sanctuaire au moins depuis l’extrême fin du VIe siècle. En effet, le règlement liturgique établit par Aunaire, évêque d’Auxerre de 561 à 604, mentionne Epponiacus dans la liste des sanctuaires auxerrois, sans que le vocable de l’église d’Appoigny ne soit précisé. Par ailleurs, depuis au moins le IXe siècle, une tradition, reprise par ...

  6. The Collected Works of Eugene Paul Wigner the Scientific Papers

    CERN Document Server

    Wigner, Eugene Paul

    1993-01-01

    Eugene Wigner is one of the few giants of 20th-century physics His early work helped to shape quantum mechanics, he laid the foundations of nuclear physics and nuclear engineering, and he contributed significantly to solid-state physics His philosophical and political writings are widely known All his works will be reprinted in Eugene Paul Wigner's Collected Workstogether with descriptive annotations by outstanding scientists The present volume begins with a short biographical sketch followed by Wigner's papers on group theory, an extremely powerful tool he created for theoretical quantum physics They are presented in two parts The first, annotated by B Judd, covers applications to atomic and molecular spectra, term structure, time reversal and spin In the second, G Mackey introduces to the reader the mathematical papers, many of which are outstanding contributions to the theory of unitary representations of groups, including the famous paper on the Lorentz group

  7. Preferencias de los huéspedes de hostels de la ciudad de La Plata

    OpenAIRE

    De la Cruz, Gastón Miguel

    2013-01-01

    La presente tesis tiene como objeto estudiar las preferencias de huéspedes de un grupo de hostels de la ciudad de La Plata, con el fin de determinar la existencia de una demanda que tenga como principal preferencia a un atributo de índole social. Para cumplir con este objetivo se utilizó la técnica estadística análisis conjunto (conjoint analysis en inglés) la cual obligó a descomponer el concepto hostel en seis (6) atributos, de los cuales tres (3) atributos entran en la definición de índole...

  8. Cooperative interplay of let-7 mimic and HuR with MYC RNA

    OpenAIRE

    Gunzburg, Menachem J; Sivakumaran, Andrew; Pendini, Nicole R; Yoon, Je-Hyun; Gorospe, Myriam; Wilce, Matthew Cj; Wilce, Jacqueline A

    2015-01-01

    Both RNA-binding proteins (RBP) and miRNA play important roles in the regulation of mRNA expression, often acting together to regulate a target mRNA. In some cases the RBP and miRNA have been reported to act competitively, but in other instances they function cooperatively. Here, we investigated HuR function as an enhancer of let-7-mediated translational repression of c-Myc despite the separation of their binding sites. Using an in vitro system, we determined that a let-7 mimic, consisting of...

  9. Inhibition of cell division in hupA hupB mutant bacteria lacking HU protein.

    OpenAIRE

    Dri, A M; Rouviere-Yaniv, J; Moreau, P L

    1991-01-01

    Escherichia coli hupA hypB double mutants that lack HU protein have severe cellular defects in cell division, DNA folding, and DNA partitioning. Here we show that the sfiA11 mutation, which alters the SfiA cell division inhibitor, reduces filamentation and production of anucleate cells in AB1157 hupA hupB strains. However, lexA3(Ind-) and sfiB(ftsZ)114 mutations, which normally counteract the effect of the SfiA inhibitor, could not restore a normal morphology to hupA hupB mutant bacteria. The...

  10. MicroRNA-16 Modulates HuR Regulation of Cyclin E1 in Breast Cancer Cells

    Directory of Open Access Journals (Sweden)

    Xun Guo

    2015-03-01

    Full Text Available RNA binding protein (RBPs and microRNAs (miRNAs or miRs are post-transcriptional regulators of gene expression that are implicated in development of cancers. Although their individual roles have been studied, the crosstalk between RBPs and miRNAs is under intense investigation. Here, we show that in breast cancer cells, cyclin E1 upregulation by the RBP HuR is through specific binding to regions in the cyclin E1 mRNA 3' untranslated region (3'UTR containing U-rich elements. Similarly, miR-16 represses cyclin E1, dependent on its cognate binding sites in the cyclin E1 3'UTR. Evidence in the literature indicates that HuR can regulate miRNA expression and recruit or dissociate RNA-induced silencing complexes (RISC. Despite this, miR-16 and HuR do not affect the other’s expression level or binding to the cyclin E1 3'UTR. While HuR overexpression partially blocks miR-16 repression of a reporter mRNA containing the cyclin E1 3'UTR, it does not block miR-16 repression of endogenous cyclin E1 mRNA. In contrast, miR-16 blocks HuR-mediated upregulation of cyclin E1. Overall our results suggest that miR-16 can override HuR upregulation of cyclin E1 without affecting HuR expression or association with the cyclin E1 mRNA.

  11. The strangest man. The hidden life of Paul Dirac; Der seltsamste Mensch. Das verborgene Leben des Quantengenies Paul Dirac

    Energy Technology Data Exchange (ETDEWEB)

    Farmelo, Graham

    2016-07-01

    The Strangest Man is the Costa Biography Award-winning account of Paul Dirac, the famous physicist sometimes called the British Einstein. He was one of the leading pioneers of the greatest revolution in twentieth-century science: quantum mechanics. The youngest theoretician ever to win the Nobel Prize for Physics, he was also pathologically reticent, strangely literal-minded and legendarily unable to communicate or empathize. Through his greatest period of productivity, his postcards home contained only remarks about the weather. Based on a previously undiscovered archive of family papers, Graham Farmelo celebrates Dirac's massive scientific achievement while drawing a compassionate portrait of his life and work. Farmelo shows a man who, while hopelessly socially inept, could manage to love and sustain close friendship. The Strangest Man is an extraordinary and moving human story, as well as a study of one of the most exciting times in scientific history.

  12. Discurso narrativo e presente histórico em Paul Ricoeur = Narrative discourse and historical present in Paul Ricoeur

    Directory of Open Access Journals (Sweden)

    Leal, Ivanhoé Albuquerque

    2016-01-01

    Full Text Available Analisamos uma das teses da teoria narrativa de Paul Ricoeur que concede ao discurso histórico a habilidade de configurar a experiência temporal humana, sempre exposta à trama de perspectivas cruzadas entre a expectativa do futuro, a recepção do passado e a vivência do presente. Face à multiplicidade do tempo, os lineamentos argumentativos ricoeurianos indicam o ato narrativo como a condição tanto de pensar a efetividade das ações humanas e sua reconstrução histórica, quanto de forjar uma unidade plural própria a uma consciência hermenêutica

  13. 75 FR 67303 - Determinations of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur...

    Science.gov (United States)

    2010-11-02

    ... of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur/Douglas PM 10... proposes to determine that the Hayden, Nogales, and Paul Spur/Douglas nonattainment areas in Arizona... Hayden, Nogales and Paul Spur/Douglas nonattainment areas are not currently attaining the PM 10 standard...

  14. 78 FR 46938 - St. Paul Park Refining Co. LLC v. Enbridge Pipelines (North Dakota) LLC; Notice of Complaint

    Science.gov (United States)

    2013-08-02

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. OR13-28-000] St. Paul Park..., 2013, St. Paul Park Refining Co. LLC (Complainant) filed a formal complaint against Enbridge Pipelines... regulatory basis. St. Paul Park Refining Co. LLC certifies that copies of the complaint were served on the...

  15. HuH-7 reference genome profile: complex karyotype composed of massive loss of heterozygosity.

    Science.gov (United States)

    Kasai, Fumio; Hirayama, Noriko; Ozawa, Midori; Satoh, Motonobu; Kohara, Arihiro

    2018-05-17

    Human cell lines represent a valuable resource as in vitro experimental models. A hepatoma cell line, HuH-7 (JCRB0403), has been used extensively in various research fields and a number of studies using this line have been published continuously since it was established in 1982. However, an accurate genome profile, which can be served as a reliable reference, has not been available. In this study, we performed M-FISH, SNP microarray and amplicon sequencing to characterize the cell line. Single cell analysis of metaphases revealed a high level of heterogeneity with a mode of 60 chromosomes. Cytogenetic results demonstrated chromosome abnormalities involving every chromosome in addition to a massive loss of heterozygosity, which accounts for 55.3% of the genome, consistent with the homozygous variants seen in the sequence analysis. We provide empirical data that the HuH-7 cell line is composed of highly heterogeneous cell populations, suggesting that besides cell line authentication, the quality of cell lines needs to be taken into consideration in the future use of tumor cell lines.

  16. Inhibition of cell division in hupA hupB mutant bacteria lacking HU protein.

    Science.gov (United States)

    Dri, A M; Rouviere-Yaniv, J; Moreau, P L

    1991-01-01

    Escherichia coli hupA hypB double mutants that lack HU protein have severe cellular defects in cell division, DNA folding, and DNA partitioning. Here we show that the sfiA11 mutation, which alters the SfiA cell division inhibitor, reduces filamentation and production of anucleate cells in AB1157 hupA hupB strains. However, lexA3(Ind-) and sfiB(ftsZ)114 mutations, which normally counteract the effect of the SfiA inhibitor, could not restore a normal morphology to hupA hupB mutant bacteria. The LexA repressor, which controls the expression of the sfiA gene, was present in hupA hupB mutant bacteria in concentrations half of those of the parent bacteria, but this decrease was independent of the specific cleavage of the LexA repressor by activated RecA protein. One possibility to account for the filamentous morphology of hupA hupB mutant bacteria is that the lack of HU protein alters the expression of specific genes, such as lexA and fts cell division genes. Images PMID:2019558

  17. Validation of whole-blood transcriptome signature during microdose recombinant human erythropoietin (rHuEpo) administration.

    Science.gov (United States)

    Wang, Guan; Durussel, Jérôme; Shurlock, Jonathan; Mooses, Martin; Fuku, Noriyuki; Bruinvels, Georgie; Pedlar, Charles; Burden, Richard; Murray, Andrew; Yee, Brendan; Keenan, Anne; McClure, John D; Sottas, Pierre-Edouard; Pitsiladis, Yannis P

    2017-11-14

    Recombinant human erythropoietin (rHuEpo) can improve human performance and is therefore frequently abused by athletes. As a result, the World Anti-Doping Agency (WADA) introduced the Athlete Biological Passport (ABP) as an indirect method to detect blood doping. Despite this progress, challenges remain to detect blood manipulations such as the use of microdoses of rHuEpo. Forty-five whole-blood transcriptional markers of rHuEpo previously derived from a high-dose rHuEpo administration trial were used to assess whether microdoses of rHuEpo could be detected in 14 trained subjects and whether these markers may be confounded by exercise (n = 14 trained subjects) and altitude training (n = 21 elite runners and n = 4 elite rowers, respectively). Differential gene expression analysis was carried out following normalisation and significance declared following application of a 5% false discovery rate (FDR) and a 1.5 fold-change. Adaptive model analysis was also applied to incorporate these markers for the detection of rHuEpo. ALAS2, BCL2L1, DCAF12, EPB42, GMPR, SELENBP1, SLC4A1, TMOD1 and TRIM58 were differentially expressed during and throughout the post phase of microdose rHuEpo administration. The CD247 and TRIM58 genes were significantly up- and down-regulated, respectively, immediately following exercise when compared with the baseline both before and after rHuEpo/placebo. No significant gene expression changes were found 30 min after exercise in either rHuEpo or placebo groups. ALAS2, BCL2L1, DCAF12, SLC4A1, TMOD1 and TRIM58 tended to be significantly expressed in the elite runners ten days after arriving at altitude and one week after returning from altitude (FDR > 0.059, fold-change varying from 1.39 to 1.63). Following application of the adaptive model, 15 genes showed a high sensitivity (≥ 93%) and specificity (≥ 71%), with BCL2L1 and CSDA having the highest sensitivity (93%) and specificity (93%). Current results provide further evidence that

  18. The Use of Soluble Transferrin Receptor in the Detection of rHuEPO abuse in Sports

    Directory of Open Access Journals (Sweden)

    Donovan McGrowder

    2010-01-01

    Full Text Available Erythropoietin (EPO increases the number of circulating erythrocytes and muscle oxygenation. The recombinant forms of EPO have indiscriminately been used by athletes, mainly in endurance sports to increase their erythrocytes concentration, thus generating a better delivery of oxygen to the muscle tissue. The administration of recombinant human erythropoietin (rHuEPO except for therapeutic use was prohibited by the International Olympic Committee (IOC and its unauthorized use considered as doping. In the last few years, a number of studies using parameters indicative of accelerated erythropoiesis have investigated a number of indirect methods for the detection of rHuEPO abuse. No single indirect marker has been found that can satisfactorily demonstrated rHuEPO misuse. Soluble transferrin receptor (sTfR is a new marker of iron status and erythropoietic activity. It has been included in multivariable blood testing models for the detection of performance enhancing EPO abuse in sports. Indirect markers of altered erythropoiesis give reliable evidence of current or discontinued rHuEPO usage. This review describes the physical, biological and pharmacokinetic properties of endogenous EPO and its recombinant form. It also discusses the available strategies for the detection of rHuEPO abuse in sports, involving the use of sTfR concentration directly or in mathematical multivariate models.

  19. HuR binding to AU-rich elements present in the 3' untranslated region of Classical swine fever virus

    Directory of Open Access Journals (Sweden)

    Huang Chin-Cheng

    2011-07-01

    Full Text Available Abstract Background Classical swine fever virus (CSFV is the member of the genus Pestivirus under the family Flaviviridae. The 5' untranslated region (UTR of CSFV contains the IRES, which is a highly structured element that recruits the translation machinery. The 3' UTR is usually the recognition site of the viral replicase to initiate minus-strand RNA synthesis. Adenosine-uridine rich elements (ARE are instability determinants present in the 3' UTR of short-lived mRNAs. However, the presence of AREs in the 3' UTR of CSFV conserved in all known strains has never been reported. This study inspects a possible role of the ARE in the 3' UTR of CSFV. Results Using RNA pull-down and LC/MS/MS assays, this study identified at least 32 possible host factors derived from the cytoplasmic extracts of PK-15 cells that bind to the CSFV 3' UTR, one of which is HuR. HuR is known to bind the AREs and protect the mRNA from degradation. Using recombinant GST-HuR, this study demonstrates that HuR binds to the ARE present in the 3' UTR of CSFV in vitro and that the binding ability is conserved in strains irrespective of virulence. Conclusions This study identified one of the CSFV 3' UTR binding proteins HuR is specifically binding to in the ARE region.

  20. Interview med professor Paul du Gay om bureaukratiets værdi

    DEFF Research Database (Denmark)

    Pors, Anja Svejgaard

    2013-01-01

    Paul du Gay er sociolog og globaliseringsprofessor ved Institut for Organisation på Copenhagen Business School. I hans forskning interesserer han sig blandt andet for bureaukratiet som styreform. Gennem årtier har bureaukratiet været genstand for omfattende kritik for dets langsommelighed......, inhumanitet og manglende fleksibilitet. Paul du Gay har taget til genmæle og forsvarer bureaukratiet som en styreform, der understøtter demokrati. I arbejdet med administration som praksis og faglighed har vi interviewet Paul du Gay om nogle af de centrale pointer i denne forskning. Samtalen kredser om...

  1. Comparison of the Debye–Hückel and the Mean Spherical Approximation Theories for Electrolyte Solutions

    DEFF Research Database (Denmark)

    Maribo-Mogensen, Bjørn; Kontogeorgis, Georgios M.; Thomsen, Kaj

    2012-01-01

    The thermodynamics of electrolyte solutions has been investigated by many scientists throughout the last century. While several theories have been presented, the most popular models for the electrostatic interactions are based on the Debye–Hückel and mean spherical approximation (MSA) theories....... In this paper we investigate the differences between the Debye–Hückel and the MSA theories, and comparisons of the numerical results for the Helmholtz energy and its derivatives with respect to temperature, volume and composition are presented. The investigation shows that the nonrestricted primitive MSA...... theory performs similarly to Debye–Hückel, despite the differences in the derivation. We furthermore show that the static permittivity is a key parameter for both models and that in many cases it completely dominates the results obtained from the two models. Consequently, we conclude that the simpler...

  2. Hu Hong’ (bad thing: parental perceptions of teenagers’ sexuality in urban Vietnam

    Directory of Open Access Journals (Sweden)

    Lan Anh Thi Do

    2017-02-01

    Full Text Available Abstract Background Teenagers under 18 years old in Vietnam are considered as minors who usually lack the autonomy to make decisions. They are also sometimes viewed as contributors to social evils including crime, violence and substance use. Moreover, most Vietnamese teenagers have unsafe sex before marriage. The objective of this study is to explore the parental perceptions relating to their teenagers’ sexuality, particularly the social and cultural forces, that may hinder access to sexuality information. Methods Guided by a Community Advisory Board (CAB, this qualitative study uses four focus group discussions (FGDs consisting of 12 mothers and 12 fathers, as well as twelve individual in-depth interviews (IDIs with a diverse sample of parents of teens in Ho Chi Minh City (HCMC, Vietnam. Content and discourse analysis were conducted, based on Foucauldian concepts. Results Four themes emerged: 1 Meanings of sexuality and sexuality education, 2 Early sexual intercourse destroys teenagers’ future, 3 Teenagers are not hu hong (spoil/bad thing, are innocent and virgin, and 4 Policing and controlling of sexual intercourse among teens. Parents did not view their teenage children as sexual beings; those who are sexual are considered hu hong. Parents believed that teens need to be policed and controlled to prevent them from becoming hu hong, particularly girls. Controlling of sexuality information by parents was therefore common in HCMC, but differed by gender and educational levels of parents. For example, fathers more than mothers were not comfortable teaching their teenage children about sex and sexuality. Parents with higher education police their teenage children’s usage of the Internet and social media, while parents with lower education control who can be friends with their teenage children. Conclusions Vietnamese parents in general have negative views of sex and sexuality education for their teenage children. Recognizing that many

  3. Characterization of the hypothermic effect of the synthetic cannabinoid HU-210 in the rat. Relation to the adrenergic system and endogenous pyrogens.

    Science.gov (United States)

    Ovadia, H; Wohlman, A; Mechoulam, R; Weidenfeld, J

    1995-02-01

    In the present study we have characterized the hypothermic effect of the psychoactive cannabinoid HU-210, by investigating its interaction with the endogenous pyrogens, IL-1 and PGE2. We also studied the involvement of the adrenergic system in mediation of this hypothermic effect. Injection of HU-210 directly into the preoptic area caused a dose dependent reduction of rectal temperature from 37 to 32.1 degrees C. Injection of the non-psychoactive analog, HU-211 which does not bind to brain cannabinoid receptor, did not affect body temperature. Injection of the adrenergic agonists, CGP-12177 and clonidine (beta, and alpha adrenergic agonists, respectively) abrogated the hypothermia induced by HU-210. Injection of the adrenergic antagonists, prazosin (alpha 1) and propranolol (beta) enhanced the hypothermic effect of HU-210. Intracerebral administration of IL-1 or PGE2 to rats pretreated with HU-210 caused a transient inhibition of the hypothermia. The ex vivo rate of basal or bacterial endotoxin-induced synthesis of PGE2 by different brain regions, including the preoptic area was not affected by HU-210 administration. These results suggest that the synthetic cannabinoid HU-210 acts in the preoptic area, probably via the brain cannabinoid receptor to induce hypothermia. The hypothermic effect can be antagonized by adrenergic agonists and enhanced by adrenergic antagonists. HU-210 does not interfere with the pyrogenic effect of IL-1 or PGE2.

  4. Iodine-131-labelled CDR grafted monoclonal antibody huA33 metastatic colorectal carcinoma: A case study

    International Nuclear Information System (INIS)

    Thomas, D.L.; Lee, F.T.; Scott, A.M.

    1997-01-01

    Full text: A 58-year-old woman was diagnosed with metastatic colorectal carcinoma two years after initial surgery for sigmoid carcinoma. As part of the staging work-up she was initially referred for a 18 F-FDG PET scan at the PET Centre. FDG PET scans of the abdomen and pelvis demonstrated multiple hepatic lesions, but there was no evidence of disease outside the liver. On the basis of extensive hepatic disease, the patient was scheduled for a laparotomy for insertion of an hepatic artery catheter for chemotherapy. In view of her clinical presentation, the patient was eligible for a Phase 1 trial with 131 l-labelled huA33, and agreed to participate. HuA33 is a humanised CDR-grafted recombinant monoclonal antibody directed against an antigen found on >95 per cent of all colorectal carcinomas, and on small bowel and colonic mucosa. The phase 1 trial is a protein dose escalation study designed to examine the biodistribution, pharmacokinetics, dosimetry and safety profile of huA33, and sequential gamma camera images of the whole body were obtained daily until seven days post infusion. SPECT images were obtained on day 6. Excellent localisation of 131 l-huA33 was seen in hepatic lesions. Calculation of whole body retention and tumour uptake was performed, and pharmacokinetic analysis also undertaken. Biopsies of tumour obtained at surgery were used to quantitate tumour uptake and cellular trafficking of 131 l-huA33. On the basis of this phase 1 study, future therapeutic trials of 131 I-huA33 are planned

  5. National Cooperative rHu Erythropoietin Study in patients with chronic renal failure--an interim report. The National Cooperative rHu Erythropoietin Study Group.

    Science.gov (United States)

    Levin, N W; Lazarus, J M; Nissenson, A R

    1993-08-01

    This second interim report of the National Cooperative rHu Erythropoietin Study presents data from 324 patients new to recombinant human erythropoietin (Epoetin alfa) who completed at least 12 months of study participation. Mean hematocrit levels increased to approximately 30% by month 3 in patients on hemodialysis (n = 293) and stabilized for the remainder of the study whether Epoetin alfa was administered by the intravenous (n = 250) or subcutaneous (n = 42) route. The intravenous dosage level ranged between 106.9 and 121.6 U/kg/wk; subcutaneous dosing ranged between 87.4 and 108.0 U/kg/wk; dosing levels in patients on peritoneal dialysis (n = 31) were similar, although there was a trend towards slightly higher hematocrit levels. Throughout the 12 months of the study, there was no relationship between blood pressure and either hematocrit level or Epoetin alfa dose. Approximately two thirds of the patients were receiving iron supplementation at any given time, and there was a trend towards the increased use of oral iron supplements. The incidence of adverse events in this cohort of patients was low throughout the study, and there was no relationship between the incidence of adverse events and either hematocrit level or Epoetin alfa dose. Based on an analysis of data from baseline to first follow-up, Epoetin alfa therapy resulted in improvement in several quality-of-life factors, most notable of which was vitality. Improvement occurred in all patient subgroups with some variability in the level and intensity of effect. Overall, these data demonstrate that Epoetin alfa therapy is safe and effective when used in a broad cross-section of patients on dialysis.(ABSTRACT TRUNCATED AT 250 WORDS)

  6. One More Legacy of Paul F. Brandwein: Creating Scientists

    Science.gov (United States)

    Fort, Deborah C.

    2011-06-01

    This paper studies the influence of Paul F. Brandwein, author, scientist, teacher and mentor, publisher, humanist, and environmentalist, on gifted youngsters who later became scientists, based primarily on information gathered from surveys completed by 25 of his students and one colleague. It also traces his profound interactions with science educators. It illuminates the theories of Brandwein and his protégés and colleagues about the interaction of environment, schooling, and education and Brandwein's belief in having students do original research (that is, research whose results are unknown) on their way to discovering their future scientific paths. It tests Brandwein's 1955 hypothesis on the characteristics typical of the young who eventually become scientists, namely: Three factors are considered as being significant in the development of future scientists: a Genetic Factor with a primary base in heredity (general intelligence, numerical ability, and verbal ability); a Predisposing Factor, with a primary base in functions which are psychological in nature; an Activating Factor, with a primary base in the opportunities offered in school and in the special skills of the teacher. High intelligence alone does not make a youngster a scientist (p xix).

  7. PAUL TILLICH UNDERSTANDING ABOUT THE BIBLE FROM A INTERRELIGIOUS PERSPECTIVE

    Directory of Open Access Journals (Sweden)

    Thiago Pinheiro

    2015-04-01

    Full Text Available Paul Tillich is more alluded as systematic theologian than as a thinker who moves within hermeneutical and exegetical fields. Similarly, his work is recognized as a Christological and ontological development than as writings that promote inter-religious dialogue. However, his works can be one of both Bible interpretation and opening to other religions. Thus, this proposal aims to understand the place of the Bible in the thought of Tillich, both in theological perspective and in inter-religious perspective. He believes that the Bible is the source of systematic theology for the fact of being the original document in which the Christian church is grounded. The revelation of Jesus as the Christ in the Bible is opened for inter-religious reflection. So the question that guides this proposal asks how the Bible as a source of theological work, allows to Christian theology dialogue with other religions. An answer to this question lies in the proposed of Tillich through deliteralization project. There are two aspects of deliteralization: the first is the preservation of myth/symbol, the second is the no-literal treatment, which allows the use of the Bible as a source of systematic theology. These two aspects allow talk about the universality of Christ event. The deliteralization may cause a greater range of the Christian message, as the opening so that its message points beyond itself, since it allows the preservation of the myth and the valuation of symbols.

  8. Paul Valéry’s Theory of Poetic Action

    Directory of Open Access Journals (Sweden)

    Anna Maria Brigante

    2013-07-01

    Full Text Available This article purports to show that Paul Valéry’s poetic art is, in the end, a theory of poeticaction in which the main concern revolves around the work in progress rather than in the final product. Todo so, we follow the poet’s critique (with deep wittgensteinian elements of classic aesthetics’ stance on beauty and taste. In our view, this reflection results in Valéry’s proposal of a poetics which can be explained in three moments: poiein of reception – the recipient as producer; poiein in its proper sense – the produceras creator of the work and him/herself; and artificialist poiein – the creator as opposed to natural creation.Valéry’s emphasis on poiesis and, therefore, on the action exerted upon what is being done, makes his proposal also an ethical assertion: the artist’s action, his/her discipline whilst producing, create both thework and the artist. Thus, the spirit will also be a never-ending work in progress.

  9. An Ecocritical Reading of Paul Bowles's The Sheltering Sky

    Directory of Open Access Journals (Sweden)

    Hossein Sheikhzadeh

    2017-07-01

    Full Text Available Landscapes are not simply something objective and unchallenged out there but the work of the mind made by the strata of memory. This paper attempts to show that an ecocritical reading of Paul Bowles’s The Sheltering Sky (1949 helps one in better understanding of this novel of post-colonial alienation and existential despair. Bowles is an American writer and a composer who is undoubtedly the most arresting example of cross-cultural influence concerning a Western author and the Middle East and North Africa.  His fiction mostly focuses on American expatriates travelling in exotic locations. The Sheltering Sky is an encounter with the Sahara, not only the physical one but the desert of moral nihilism into which one may wander blindly. The boundless desert acts here as a metaphor and the journey symbolizes one’s own journey into the depth of his/her soul. The desert also projects an apocalyptic vision in the struggle between the West and the East and the Sahara becomes in fact a Conradian Heart of Darkness, an Eliotian Waste Land, and a Sartrean No Exit. In the novel the actual environment becomes in some ways pale and covert under the psyche of the writer. Consequently we come to know that Bowles's own knowledge and awareness of the same environments left traces in his work. Accordingly we may wrap up that the environment bears a direct impact on our understanding of it.

  10. Paul Slabolepszy’s angst-ridden Elvis

    Directory of Open Access Journals (Sweden)

    M. van Deventer

    2000-04-01

    Full Text Available Paul Slabolepszy is a popular South African playwright whose plays are enjoyed by diverse multi-cultural audiences in South Africa and all over the world. Slabolepszy’s special appeal lies in his ability to reflect in his plays an authentic South African landscape with its stormy political background, diverse cultures and inhabitants, and to evoke empathy for all of his characters within this South African milieu through a variety of comic techniques. The play, The Return of Elvis du Pisanie, first performed 10 years after Slabolepszy's breakthrough play, Saturday Night at the Palace (1985, is apolitical and focuses on the plight of a white South African male. This popular play’s appeal is universal for Slabolepszy throughout evokes empathy by comically reviving with superb conviction the nostalgia of the Elvis-era, which most people are able to understand and even identify with. Through humour which is comic, sensitive and insightful, he is able to evoke empathy for his angst-ridden main character, the typical “bloke-next-door". His combination of a surreal dimension with comic humour and pathos is able to make us laugh and even wipe away a tear in this way he also intensifies our feelings of empathy for his believable and identifiable protagonist, as he takes us on a nostalgic journey through the fifties to the present, with the legendary Elvis Presley functioning as the binding force.

  11. Experimental study of resonance crossing with a Paul trap

    Directory of Open Access Journals (Sweden)

    H. Takeuchi

    2012-07-01

    Full Text Available The effect of resonance crossing on beam stability is studied systematically by employing a novel tabletop experimental tool and a multiparticle simulation code. A large number of ions are confined in a compact linear Paul trap to reproduce the collective beam behavior. We can prove that the ion plasma in the trap is physically equivalent to a charged-particle beam propagating through a strong focusing channel. The plasma confinement force is quickly ramped such that the trap operating point traverses linear and nonlinear resonance stop bands. Assuming a nonscaling fixed field alternating gradient accelerator composed of many identical FODO cells, we measure how much ion losses occur under diverse conditions. It is experimentally and numerically demonstrated that too slow resonance crossing leads to significant ion losses as expected. Particular attention must be paid to the linear coherent resonance excited at a quarter-integer tune. When the beam intensity is high, this type of linear stop band can seriously affect the beam quality even for rather fast resonance crossing. A scaling law is given of the emittance growth caused by the quarter-integer resonance crossing.

  12. EL PSICOANÁLISIS EXISTENCIAL DE JEAN-PAUL SARTRE

    Directory of Open Access Journals (Sweden)

    Alfonso Rodríguez M.

    2001-01-01

    Full Text Available Esta ponencia se refiere al aparte «El psicoanálisis existencial», sección I del capítulo II de la cuarta parte del libro El ser y la nada, de Jean-Paul Sartre (JPS, publicado por ediciones Gallimard en 1943. Este aparte del libro básicamente define lo que entiende JPS por psicoanálisis existencial, por oposición a los llamados por él «psicoanálisis empírico» y «psicoanálisis de Freud y sus discípulos». Este capítulo es además importante porque aquí se encuentran varios de los temas más recurrentes en la filosofía sartriana, como son los temas de la libertad, Dios como para– sí del hombre y la razón como luz que descubre las últimas evidencias. A pesar de la reconocida «inspiración freudiana», además de Freud, este aparte arremete contra algunos de los pensadores que critica la obra sartriana: Kant, Nietzsche, Heidegger.

  13. Paul Gauguin and the origin of Art Noveau

    Science.gov (United States)

    Asmus, John F.

    1997-10-01

    Since the turn of the century there has been widespread acknowledgement that Alphonse Mucha inspired the birth of the Art Nouveau movement when he created the 'Gismonda' poster advertising the opening of the Sarah Bernhardt play of that name in Paris in 1894. At an estate sale in 1954 a small collage bearing a likeness of the Mucha 'Gismonda' was offered. It was composed of fragments of sixty postage stamps glued to a small ceramic tile. Digital computer image processing has been applied to the collage design, scratches on the handle of a walking stick in the same collection, and the Mucha poster. From comparative analyses of the enhanced 'Gismonda' images it is revealed that the little collage is considerably more detailed and compete than the Mucha 'original'. Thus, it is concluded that the poster is a hasty photographic plagiarism of the intricate collage. Further image processing of the scratches on the handle of the walking stick and the collage reveal them to conform to the famous and enigmatic 'P GO' monogram signature of the artist Paul Gauguin. Thus, it follows that the original design was created by Gauguin rather than by Mucha. It may be that while Gauguin was in Brittany recovering from injuries sustained in a brawl his former lover, Annah la Javanese, pilfered his belongings and took them with her to Paris and her next lover, photographer-designer, Alphonse Mucha, who copied the collage and offered it as the Gismonda Poster.

  14. Paul Signac's Decorative Propaganda of the 1890s

    Directory of Open Access Journals (Sweden)

    Brion, Katherine

    2012-07-01

    Full Text Available In the 1890s the political and artistic ambitions of the neo-impressionist artist Paul Signac were embodied by a series of decorative projects. This article contends that Signac, inspired by anarcho-communist discourse and the prospect of revolution, attempted to synthesize in these works the didactic logic of propaganda and "purely aesthetic emotion." This synthesis was epitomized by the explicit deployment of two systems, divisionism and decorative pattern. With these systems, Signac hoped to initiate contemporary viewers into the aesthetic and social harmony of an anarcho-communist future. In the interest of addressing larger audiences, particularly among workers, he imagined proletarian spaces for his work. But the didactic elements of Signac's painting met with critical resistance, and public sites he envisioned never materialized. Faced with this lack of recognition, and with a diminished revolutionary outlook in the wake of the Procès des Trente, Signac focused his painting on atemporal landscapes. This trajectory has been read as one of aesthetic liberation; this article seeks to retrieve the extent to which it was also one of constraint, tied to the frustration of Signac's political aspirations.

  15. First International Workshop on Human Factors in Modeling (HuFaMo 2015)

    DEFF Research Database (Denmark)

    Störrle, Harald; Chaudron, Michel R. V.; Amaral, Vasco

    2015-01-01

    human factors in modeling. Our goal is to improve the state of the science and professionalism in empirical research in the Model Based Engineering community. Typical examples of research questions might consider the usability of a certain approach, such as a method or language, or the emotional states......Modeling is a human-intensive enterprise. As such, many research questions related to modeling can only be answered by empirical studies employing human factors. The International Workshop Series on Human Factors in Modeling (HuFaMo) is dedicated to the discussion of empirical research involving...... or personal judgements of modelers. While concerned with foundations and framework support for modeling, the community has been somehow neglecting the issue of human factors in this context. There is a growing need from the community concerned with quality factors to understand the best practices...

  16. La voz y la letra en "Un huésped", de Yoko Tawada

    Directory of Open Access Journals (Sweden)

    María Lucía Correa

    2009-05-01

    Full Text Available Los textos de Yoko Tawada, escritorajaponesa residente en Alemania,hacen presente el desgarramientode quien vive fuera de la lenguamaterna. Es una obra que se balanceasobre el límite entre loscódigos, donde nada hay evidente,donde la palabra parece tener vidapropia. Entre los textos que tomanesta extrañeza del lenguaje comosustrato, se encuentra el relato"Un huésped", cuya particular referenciaa la voz y a la letra comodos registros que se entrelazan yse repelen alternativamente, loconvierte en una valiosa fuente dereflexiones sobre lo oral, la voz, laletra, la lectura y la escritura.Palabras clave: Yoko Tawada, literaturajaponesa contemporánea, voz,letra, escritura.

  17. Spectroscopy of bright Algol-type semi-detached close binary system HU Tauri (HR 1471)

    Science.gov (United States)

    Parthasarathy, M.

    2018-01-01

    Radial velocities of the primary component (B8V) of HU Tauri derived from the photographic spectra obtained during January 1974 to December 1974 and spectroscopic orbital elements from the analysis of the radial velocity curve of the B8V primary are given. The H line of the late type secondary component is clearly detected on the photographic spectra taken around the quadratures and radial velocities of the secondary component are derived. The radial velocity semi amplitudes of the primary (K) and secondary (K) are found to be 60 km/sec and 234 km/sec respectively. The mass ratio M/M = K/K is found to be 0.2564. The detection of the H line of the secondary is confirmed from the high resolution spectra that I obtained during 1981 and 1983 at quadratures using the 2.1-m McDonald observatory Otto Struve reflector telescope and high resolution coude Reticon spectrograph.

  18. Der andere Kisch: der Literaturhistoriker und –kritiker Paul Kisch (1883–1944)

    Czech Academy of Sciences Publication Activity Database

    Petrbok, Václav

    2015-01-01

    Roč. 23, 1-2 (2015), s. 79-100 ISSN 1803-456X Institutional support: RVO:68378068 Keywords : Kisch, Paul * literary criticism * Czech-German relationships * intercultural studies Subject RIV: AJ - Letters, Mass-media, Audiovision

  19. Matthew, Paul and the origin and nature of the gentile mission: The ...

    African Journals Online (AJOL)

    p1243322

    previous restriction of the mission to Israel alone and demands that the disciples .... The relationship between Matthew and Paul has never been at the forefront of. Matthean studies. For the ..... eat the children's' crumbs”. London: T & T Clark.

  20. Paul Hill d/b/a Alternative Energy Windows and Siding

    Science.gov (United States)

    Paul Hill d/b/a Alternative Energy Windows and Siding (the Company) is located in Concord, New Hampshire. The settlement involves renovation activities conducted at property constructed prior to 1978, located in Concord, New Hampshire.

  1. Peter Paul Rubens, Galileo Galilei und die Schlacht am Weißen Berg

    Czech Academy of Sciences Publication Activity Database

    Konečný, Lubomír

    2005-01-01

    Roč. 26, č. 52 (2005), s. 85-91 ISSN 0391-9064 Institutional research plan: CEZ:AV0Z80330511 Keywords : Peter Paul Rubens * Galileo Galilei * moon Subject RIV: AL - Art, Architecture, Cultural Heritage

  2. EnviroAtlas - Minneapolis/St. Paul, MN - BenMAP Results by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset demonstrates the effect of changes in pollution concentration on local populations in 1,772 block groups in Minneapolis/St. Paul, Minnesota....

  3. EnviroAtlas - Minneapolis/St. Paul, MN - Ecosystem Services by Block Group

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset presents environmental benefits of the urban forest in 1,772 block groups in Minneapolis/St. Paul, Minnesota. Carbon attributes, temperature...

  4. The complete chloroplast genome sequence of the relict woody plant Metasequoia glyptostroboides Hu et Cheng

    Directory of Open Access Journals (Sweden)

    Jinhui eChen

    2015-06-01

    Full Text Available Metasequoia glyptostroboides Hu et Cheng is the only species in the genus Metasequoia Miki ex Hu et Cheng, which belongs to the Cupressaceae family. There were around ten species in the Metasequoia genus, which were widely spread across the Northern Hemisphere during the Cretaceous of the Mesozoic and in the Cenozoic. M. glyptostroboides is the only remaining representative of this genus. Here, we report the complete chloroplast (cp genome sequence and the cp genomic features of M. glyptostroboides. The M. glyptostroboides cp genome is 131,887 bp in length, with a total of 117 genes comprised of 82 protein-coding genes, 31 tRNA genes and four rRNA genes. In this genome, 11 forward repeats, nine palindromic repeats and 15 tandem repeats were detected. A total of 188 perfect microsatellites were detected through simple sequence repeat (SSR analysis and these were distributed unevenly within the cp genome. Comparison of the cp genome structure and gene order to those of several other land plants indicated that a copy of the inverted repeat (IR region, which was found to be IR region A (IRA, was lost in the M. glyptostroboides cp ge-nome. The five most divergent and five most conserved genes were determined and further phylogenetic analysis was performed among plant species, especially for relat-ed species in conifers. Finally, phylogenetic analysis demonstrated that M. glyptostro-boides is a sister species to Cryptomeria japonica (L. F. D. Don and to Taiwania cryptomerioides Hayata. The complete cp genome sequence information of M. glyp-tostroboides will be great helpful for further investigations of this endemic relict woody plant and for in-depth understanding of the evolutionary history of the conif-erous cp genomes, especially for the position of M. glyptostroboides in plant systemat-ics and evolution.

  5. The complete chloroplast genome sequence of the relict woody plant Metasequoia glyptostroboides Hu et Cheng.

    Science.gov (United States)

    Chen, Jinhui; Hao, Zhaodong; Xu, Haibin; Yang, Liming; Liu, Guangxin; Sheng, Yu; Zheng, Chen; Zheng, Weiwei; Cheng, Tielong; Shi, Jisen

    2015-01-01

    Metasequoia glyptostroboides Hu et Cheng is the only species in the genus Metasequoia Miki ex Hu et Cheng, which belongs to the Cupressaceae family. There were around 10 species in the Metasequoia genus, which were widely spread across the Northern Hemisphere during the Cretaceous of the Mesozoic and in the Cenozoic. M. glyptostroboides is the only remaining representative of this genus. Here, we report the complete chloroplast (cp) genome sequence and the cp genomic features of M. glyptostroboides. The M. glyptostroboides cp genome is 131,887 bp in length, with a total of 117 genes comprised of 82 protein-coding genes, 31 tRNA genes and four rRNA genes. In this genome, 11 forward repeats, nine palindromic repeats, and 15 tandem repeats were detected. A total of 188 perfect microsatellites were detected through simple sequence repeat (SSR) analysis and these were distributed unevenly within the cp genome. Comparison of the cp genome structure and gene order to those of several other land plants indicated that a copy of the inverted repeat (IR) region, which was found to be IR region A (IRA), was lost in the M. glyptostroboides cp genome. The five most divergent and five most conserved genes were determined and further phylogenetic analysis was performed among plant species, especially for related species in conifers. Finally, phylogenetic analysis demonstrated that M. glyptostroboides is a sister species to Cryptomeria japonica (L. F.) D. Don and to Taiwania cryptomerioides Hayata. The complete cp genome sequence information of M. glyptostroboides will be great helpful for further investigations of this endemic relict woody plant and for in-depth understanding of the evolutionary history of the coniferous cp genomes, especially for the position of M. glyptostroboides in plant systematics and evolution.

  6. Leben mit Estland : Paul-Gerhard von Hoerschelmann zum 80. Geburtstag / Heinrich Wittram

    Index Scriptorium Estoniae

    Wittram, Heinrich

    2012-01-01

    Olles Põhja-Elbe Jutlustajate Seminari direktor alustas Paul-Gerhard von Hoerschelmann koostööd Eesti Evangeelse Luterliku Kirikuga 1988. aastal. Nõmmel sündinud pastori pojana olid tal selle koostöö arendamiseks igati head eeldused. 1997. aastal sai Paul-Gerhard Hoerschelmannist EELK Usuteaduse Instituudi rektor. Aastatel 1996-1998 teenis ta väikesearvulist saksakeelset kogudust Tallinnas. Aastast 2006 EELK' aupraost

  7. On social justice: Comparing Paul with Plato, Aristotle and the Stoics

    Directory of Open Access Journals (Sweden)

    Johan Strijdom

    2007-05-01

    Full Text Available n “In search of Paul” (2004 Crossan and Reed argue that Paul’s vision and program were essentially in continuity with Jesus’: both opposed, be it in Galilean villages or Roman cities, an unjust imperial system by means of an alternative project of egalitarian, distributive justice. Although Crossan elsewhere demonstrates the deep roots of this concern in the Jewish tradition, he tends to downplay the importance of Greek contributions in this regard. The purpose of this essay will be to offer, in constant dialogue with Crossan (and Reed, a more refined comparison of social justice in Paul on the one hand and Plato, Aristotle and the Stoics on the other. If Paul tried to establish egalitarian and sharing Christian communities under the Roman empire, how do this vision and program compare and contrast with Plato's hierarchical but communal concept of justice, Aristotle’s distributive notion according to merit, and most importantly the Stoics’ argument of “oikeiosis” (i.e., other-concern by concentrical familiarization with the other? Imagine, say Crossan and Reed (CR hereafter in their recent book on Paul, the following dialogue between ourselves and Paul: Do you think, Paul, that all men are created equal and endowed by their Creator with certain inalienable rights? I am not speaking about all men, but about all Christians. But do you think, Paul, that all people should be Christians? Yes, of course,. And do you think, Paul, that all Christians should be equal with one another?Yes, of course. Then do you think, Paul, that it is God’s will for all people to be equal with one another? Well, let me think about that one for a while and, in the meantime, you think about equality in Christ. (CR 2004:234

  8. Anti-Inflammatory and Osteoprotective Effects of Cannabinoid-2 Receptor Agonist HU-308 in a Rat Model of Lipopolysaccharide-Induced Periodontitis.

    Science.gov (United States)

    Ossola, Cesar A; Surkin, Pablo N; Mohn, Claudia E; Elverdin, Juan C; Fernández-Solari, Javier

    2016-06-01

    Anti-inflammatory and immunologic properties of cannabinoids have been reported in several tissues. Expression of cannabinoid receptor Type 2 was reported in osteoblasts and osteoclasts, suggesting a key role in bone metabolism. The aim of this study is to assess the effect of treatment with cannabinoid-2 receptor agonist HU-308 in the oral health of rats subjected to lipopolysaccharide (LPS)-induced periodontitis. Twenty-four rats were distributed in four groups (six rats per group): 1) control rats; 2) sham rats; 3) rats submitted to experimental periodontitis (LPS); and 4) rats submitted to experimental periodontitis and treated with HU-308 (LPS+HU). In groups LPS and LPS+HU, periodontitis was induced by LPS (1 mg/mL) injected into the gingival tissue (GT) of maxillary and mandibular first molars and into the interdental space between the first and second molars, 3 days per week for 6 weeks. In group LPS+HU, HU-308 (500 ng/mL) was applied topically to the GT daily. Alveolar bone loss resulting from LPS-induced periodontitis was significantly attenuated with HU-308 treatment (LPS+HU), measured by macroscopic and histologic examination. Treatment also reduced gingival production of inflammatory mediators augmented in LPS-injected rats, such as: 1) inducible nitric oxide (iNOS) activity (LPS: 90.18 ± 36.51 pmol/minute/mg protein versus LPS+HU: 16.37 ± 4.73 pmol/minute/mg protein; P periodontitis on the salivary secretory response to pilocarpine. Moreover, iNOS activity and PGE2 content, which were increased by LPS-induced periodontitis in the submandibular gland, returned to control values after HU-308 treatment. This study demonstrates anti-inflammatory, osteoprotective, and prohomeostatic effects of HU-308 in oral tissues of rats with LPS-induced periodontitis.

  9. Isolation and characterization of a catalase gene "HuCAT3" from pitaya (Hylocereus undatus) and its expression under abiotic stress.

    Science.gov (United States)

    Nie, Qiong; Gao, Guo-Li; Fan, Qing-jie; Qiao, Guang; Wen, Xiao-Peng; Liu, Tao; Peng, Zhi-Jun; Cai, Yong-Qiang

    2015-05-25

    Abiotic stresses usually cause H2O2 accumulation, with harmful effects, in plants. Catalase may play a key protective role in plant cells by detoxifying this excess H2O2. Pitaya (Hylocereus undatus) shows broad ecological adaptation due to its high tolerance to abiotic stresses, e.g. drought, heat and poor soil. However, involvement of the pitaya catalase gene (HuCAT) in tolerance to abiotic stresses is unknown. In the present study, a full-length HuCAT3 cDNA (1870 bp) was isolated from pitaya based on our previous microarray data and RACE method. The cDNA sequence and deduced amino acid sequence shared 73-77% and 75-80% identity with other plant catalases, respectively. HuCAT3 contains conserved catalase family domain and catalytic sites. Pairwise comparison and phylogenetic analysis indicated that HuCAT3 is most similar to Eriobotrya japonica CAT, followed by Dimocarpus longan CAT and Nicotiana tabacum CAT1. Expression profile analysis demonstrated that HuCAT3 is mainly expressed in green cotyledons and mature stems, and was regulated by H2O2, drought, cold and salt stress, whereas, its expression patterns and maximum expression levels varied with stress types. HuCAT activity increased as exposure to the tested stresses, and the fluctuation of HuCAT activity was consistent with HuCAT3 mRNA abundance (except for 0.5 days upon drought stress). HuCAT3 mRNA elevations and HuCAT activities changes under cold stress were also in conformity with the cold tolerances among the four genotypes. The obtained results confirmed a major role of HuCAT3 in abiotic stress response of pitaya. This may prove useful in understanding pitaya's high tolerance to abiotic stresses at molecular level. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. The PAUL Suit(©) : an experience of ageing.

    Science.gov (United States)

    Bennett, Paul; Moore, Malcolm; Wenham, John

    2016-04-01

    An ageing population worldwide makes it increasingly important that health students understand issues that elderly people face and can provide empathic care to them. This teaching department in an isolated rural setting developed an interprofessional learning session to assist health students to understand issues of functional loss and social isolation that can affect elderly people. The Premature Ageing Unisex Leisure (PAUL) Suit(©) was developed as part of a 1-day learning session for undergraduate health students - including students of medicine, nursing and allied health - attending clinical placement in far-west New South Wales. The suit was developed locally and can be adjusted to simulate a wide range of functional losses in the wearer. Students undertake a range of daily tasks in the community while wearing the suit in the company of a student 'carer'. Over the past 4 years, approximately 140 students have participated in the simulation. Post-simulation evaluations report that students gain a greater understanding of some functional issues associated with ageing, and of the social isolation that can be associated with these. The experiential nature of the activity leads to some powerful insights. This activity is an innovative, experiential tool to deepen students understanding of issues related to ageing This activity is an innovative, experiential tool to deepen students understanding of issues relating to ageing. The interprofessional nature of the activity is an important factor in the success of the day, and produces a wide range of shared insights. The activity also enhances the partnerships between the university, the health service and the local community. Our experience supports the value of simulation in providing a deep learning opportunity in the area of ageing and disability. © 2015 John Wiley & Sons Ltd.

  11. Pope John Paul II apologizes for church's oppression of women.

    Science.gov (United States)

    1995-01-01

    In a 16-page letter which is widely viewed by women's groups as an effort to win support for the Vatican's position at the upcoming UN Conference on Women in Beijing, Pope John Paul II apologizes to women throughout the world for the church's historic complicity in their oppression. Although phrased in general terms, the letter contains language and ideas of a far more feminist tone than any previous statements or declarations made by the Pontiff. Calling for increased respect for women and sensitivity to their needs, the letter also claims that "there is an urgent need to achieve real equality in every area: equal pay for equal work, protection for working mothers, fairness in career advancements, equality of spouses with regard to family rights and recognition of everything that is part of the rights and duties of citizens in a democratic state." Recognizing women's significant achievements and sacrifices inside and outside of the home, the Pope expressed admiration for "those women of good will who have devoted their lives to defending the dignity of womanhood by fighting for their basic social, economic and political rights, demonstrating courageous initiative at a time when this was considered extremely inappropriate, the sign of a lack of femininity, a manifestation of exhibitionism, and even a sin." Although the letter heralds a new awareness in the Vatican of women's views, concerns and grievances, the Pope has not signaled any dramatic changes in official church policy: women's ordination, divorce, abortion and birth control are still considered beyond the pale of acceptability. full text

  12. A conversation with Paul Greengard. Interview by Eric J Nestler.

    Science.gov (United States)

    Greengard, Paul

    2013-01-01

    Paul Greengard was born in New York City in 1925. After completing high school, he served three years in the US Navy during World War II and then completed his bachelor's degree at Hamilton College where he majored in physics and mathematics. He obtained a PhD in biophysics from Johns Hopkins University in 1953 and pursued postdoctoral training with Wilhelm Feldberg at the National Institute for Medical Research in England. After eight years as head of biochemistry at Geigy, and sabbaticals at Albert Einstein College of Medicine and Vanderbilt University, he joined the Yale University faculty as a full professor of pharmacology in 1968. While he was at Yale, Greengard's laboratory performed groundbreaking research, which demonstrated a role for cyclic nucleotides, protein kinases and protein phosphatases, and their protein substrates in the regulation of synaptic transmission. In 1983, Greengard moved to The Rockefeller University, where he has since served as the Vincent Astor Professor and Head of the Laboratory of Molecular and Cellular Neuroscience. Greengard's paradigm-shifting research has continued at Rockefeller and has informed our understanding and possible treatment of a host of brain disorders, including schizophrenia, Alzheimer's disease, Parkinson's disease, and depression. He is the author of more than 950 research articles and reviews. Greengard has received numerous awards and honors, including the Nobel Prize in Physiology or Medicine in 2000, the Metropolitan Life Foundation Award for Medical Research, The National Academy of Sciences Award in Neuroscience, the Ralph W. Gerard Prize in Neuroscience for the Society for Neuroscience, and the Karolinska Institutet's Bicentennial Gold Medal. He is a member of the US National Academy of Sciences and the Institute of Medicine of the National Academies. The following interview was conducted on May 29, 2012.

  13. The histone-like protein HU has a role in gene expression during the acid adaptation response in Helicobacter pylori.

    Science.gov (United States)

    Álvarez, Alhejandra; Toledo, Héctor

    2017-08-01

    Gastritis, ulcers, and gastric malignancy have been linked to human gastric epithelial colonization by Helicobacter pylori. Characterization of the mechanisms by which H. pylori adapts to the human stomach environment is of crucial importance to understand H. pylori pathogenesis. In an effort to extend our knowledge of these mechanisms, we used proteomic analysis and qRT-PCR to characterize the role of the histone-like protein HU in the response of H. pylori to low pH. Proteomic analysis revealed that genes involved in chemotaxis, oxidative stress, or metabolism are under control of the HU protein. Also, expression of the virulence factors Ggt and NapA is affected by the null mutation of hup gene both at neutral and acid pH, as evidenced by qRT-PCR analysis. Those results showed that H. pylori gene expression is altered by shift to low pH, thus confirming that acid exposure leads to profound changes in genomic expression, and suggest that the HU protein is a regulator that may help the bacterium adapt to the acid stress. In accordance with previous reports, we found that the HU protein participates in gene expression regulation when the microorganism is exposed to acid stress. Such transcriptional regulation underlies protein accumulation in the H. pylori cell. © 2017 John Wiley & Sons Ltd.

  14. Preliminary crystallographic analysis of the RNA-binding domain of HuR and its poly(U)-binding properties

    International Nuclear Information System (INIS)

    Wang, Hong; Li, Heng; Shi, Hui; Liu, Yang; Liu, Huihui; Zhao, Hui; Niu, Liwen; Teng, Maikun; Li, Xu

    2011-01-01

    Here, the recombinant ARE-binding region of HuR (residues 18–186) was crystallized in space group P2 1 2 1 2, with unit-cell parameters a = 41.2, b = 133.1, c = 31.4 Å. Human antigen R (HuR), a ubiquitously expressed member of the Hu protein family, is an important post-transcriptional regulator which has three RNA-recognition motif (RRM) domains. The two tandem N-terminal RRM domains can selectively bind to the AU-rich element (ARE), while the third one interacts with the poly(A) tail and other proteins. Here, the recombinant ARE-binding region of HuR (residues 18–186) was crystallized in space group P2 1 2 1 2, with unit-cell parameters a = 41.2, b = 133.1, c = 31.4 Å. X-ray diffraction data were collected to a resolution of 2.8 Å. Mutagenesis analysis and SPR assays revealed its poly(U)-binding properties

  15. Paul-Eerik Rummo : mind käimashoidev vedru on presidendiprotsess ise / Paul-Eerik Rummo ; interv. Märt Kivine

    Index Scriptorium Estoniae

    Rummo, Paul-Eerik, 1942-

    2006-01-01

    Intervjuus Reformierakonna ühe presidendikandidaadi, rahvastikuminister Paul-Eerik Rummoga käsitletakse presidendi rolli, ülesandeid, rahva ootusi, Eesti ideed Euroopas, EL-i laienemist. Tema hinnangul on võtmeteema haridus, sellest oleneb ka kõige muu õnnestumine, ka rahvuse edasikestmine

  16. Peripheral blood progenitor cell transplantation mobilised by r-metHuG-CSF (filgrastim); a less costly alternative to autologous bone marrow transplantation

    NARCIS (Netherlands)

    C.A. Uyl-de Groot (Carin); D.J. Richel (Dirk); F.F.H. Rutten (Frans)

    1994-01-01

    textabstractIn a retrospective study, we calculated the treatment costs of 63 patients who received either autologous bone marrow transplantation (ABMT) with recombinant human granulocyte colony-stimulating factor (r-metHuG-CSF) (filgrastim) (n=13) or without r-metHuG-CSF (n=22) or altenatively,

  17. Comparison of HuRAM+ and HERA for Development of Data Worksheet for Simulator based HERA Databank

    International Nuclear Information System (INIS)

    Choi, Sunyoung; Jung, Wondea

    2013-01-01

    We also compared the existing HERA methods and HERA database to select essential data fields. We performed a preliminary study to see the possibility to induce the operator's emergency operating procedure (EOP) noncompliance behaviors under a simulated emergency. The purpose of this paper is to compare the HuRAM + and HERA to obtain an insight into the construction of a data worksheet for a qualitative HERA. In this paper, we performed a case study for applying simulator training data to HuRAM + and HERA. With this insight, as well as the results of the researches mentioned above, we have a plan to develop a systematic and qualitative HERA and a data worksheet for the work. In this paper, we compared HuRAM + and HERA to obtain an insight into the construction of a data worksheet for a qualitative HERA and performed a case study. HERA requires a burden to analyze and input an event data due to too many data fields even though it is well designed to estimate Heaps. It is somewhat more convenient to input data into the HuRAM + ; however, it is difficult to analyze the organization and safety culture factors. We are now trying to develop the framework of a data worksheet for a qualitative HERA based on simulator training data. The purpose of our data worksheet is to provide key information for HEP estimation and to enhance the understanding of an operators' behavior under an off-normal plant status. We aim less encumbered means of obtaining the needed data for HERA by changing the existing data worksheet framework of HuRAM + and HERA and by reducing data fields that require reading the between the lines

  18. Microstructured segmented Paul trap with tunable magnet field gradient; Mikrostrukturierte segmentierte Paul-Falle mit einstellbarem Magnetfeldgradienten

    Energy Technology Data Exchange (ETDEWEB)

    Kaufmann, Delia

    2012-02-03

    Strings of laser cooled ions stored in microstructured Paul traps (microtraps) have promising potential for quantum information science. They provide a system which can be screened from a decohering environment, accurately prepared, manipulated and state selectively detected with efficiency close to unity. Magnetic field gradients allow for addressing trapped ions in frequency space. Furthermore, coupling of the ions' motional and spin states and long range spin-spin coupling of the ions' internal states are induced by such a gradient. This method is called Magnetic Gradient Induced Coupling, MAGIC. In this thesis, the design, construction and first characterization of a novel microtrap with an integrated solenoid is reported. The solenoid is designed to create a high magnetic field gradient per dissipated heat. The microtrap consists of three layers stacked onto each other. The outer layers provide a trapping potential, while the inner layer creates the switchable magnetic field gradient. Another specialty of this trap is the 33 pairs of DC-electrodes, allowing to move the ions along the trap axis and to adjust the range and the strength of the ions' spin-spin interactions. The microtrap is fixed on top of a ceramic block that provides the necessary electrical connections via thick film printed wires, a technique adopted in the context of microtraps for the first time, and in addition acts as a vacuum interface. The volume of the vacuum chamber is quite small, allowing for pressures in the low 10{sup -11} mbar range. In this microtrap, {sup 172}Yb{sup +}-ions are trapped, cooled and shuttled over a distance of about 2 mm. Trapped ions are used as magnetic field gradient probes, with a relative magnetic field precision of {delta}B/B{sub 0}=7.10{sup -6}. The addressing of two ions with the MAGIC method in the solenoid's magnetic field gradient is demonstrated.

  19. The RNA binding protein HuR does not interact directly with HIV-1 reverse transcriptase and does not affect reverse transcription in vitro

    Directory of Open Access Journals (Sweden)

    Gronenborn Angela M

    2010-05-01

    Full Text Available Abstract Background Lemay et al recently reported that the RNA binding protein HuR directly interacts with the ribonuclease H (RNase H domain of HIV-1 reverse transcriptase (RT and influences the efficiency of viral reverse transcription (Lemay et al., 2008, Retrovirology 5:47. HuR is a member of the embryonic lethal abnormal vision protein family and contains 3 RNA recognition motifs (RRMs that bind AU-rich elements (AREs. To define the structural determinants of the HuR-RT interaction and to elucidate the mechanism(s by which HuR influences HIV-1 reverse transcription activity in vitro, we cloned and purified full-length HuR as well as three additional protein constructs that contained the N-terminal and internal RRMs, the internal and C-terminal RRMs, or the C-terminal RRM only. Results All four HuR proteins were purified and characterized by biophysical methods. They are well structured and exist as monomers in solution. No direct protein-protein interaction between HuR and HIV-1 RT was detected using NMR titrations with 15N labeled HuR variants or the 15N labeled RNase H domain of HIV-1 RT. Furthermore, HuR did not significantly affect the kinetics of HIV-1 reverse transcription in vitro, even on RNA templates that contain AREs. Conclusions Our results suggest that HuR does not impact HIV-1 replication through a direct protein-protein interaction with the viral RT.

  20. Paul Ehrenfest, Niels Bohr, and Albert Einstein: Colleagues and Friends

    Science.gov (United States)

    Klein, Martin J.

    2010-09-01

    In May 1918 Paul Ehrenfest received a monograph from Niels Bohr in which Bohr had used Ehrenfest's adiabatic principle as an essential assumption for understanding atomic structure. Ehrenfest responded by inviting Bohr, whom he had never met, to give a talk at a meeting in Leiden in late April 1919, which Bohr accepted; he lived with Ehrenfest, his mathematician wife Tatyana, and their young family for two weeks. Albert Einstein was unable to attend this meeting, but in October 1919 he visited his old friend Ehrenfest and his family in Leiden, where Ehrenfest told him how much he had enjoyed and profited from Bohr's visit. Einstein first met Bohr when Bohr gave a lecture in Berlin at the end of April 1920, and the two immediately proclaimed unbounded admiration for each other as physicists and as human beings. Ehrenfest hoped that he and they would meet at the Third Solvay Conference in Brussels in early April 1921, but his hope was unfulfilled. Einstein, the only physicist from Germany who was invited to it in this bitter postwar atmosphere, decided instead to accompany Chaim Weizmann on a trip to the United States to help raise money for the new Hebrew University in Jerusalem. Bohr became so overworked with the planning and construction of his new Institute for Theoretical Physics in Copenhagen that he could only draft the first part of his Solvay report and ask Ehrenfest to present it, which Ehrenfest agreed to do following the presentation of his own report. After recovering his strength, Bohr invited Ehrenfest to give a lecture in Copenhagen that fall, and Ehrenfest, battling his deep-seated self-doubts, spent three weeks in Copenhagen in December 1921 accompanied by his daughter Tanya and her future husband, the two Ehrenfests staying with the Bohrs in their apartment in Bohr's new Institute for Theoretical Physics. Immediately after leaving Copenhagen, Ehrenfest wrote to Einstein, telling him once again that Bohr was a prodigious physicist, and again

  1. 89Zr-huJ591 immuno-PET imaging in patients with advanced metastatic prostate cancer

    International Nuclear Information System (INIS)

    Pandit-Taskar, Neeta; Solomon, Stephen B.; Durack, Jeremy C.; Carrasquillo, Jorge A.; Lefkowitz, Robert A.; Osborne, Joseph R.; O'Donoghue, Joseph A.; Beylergil, Volkan; Ruan, Shutian; Cheal, Sarah M.; Lyashchenko, Serge; Gonen, Mithat; Lewis, Jason S.; Holland, Jason P.; Reuter, Victor E.; Loda, Massimo F.; Smith-Jones, Peter M.; Weber, Wolfgang A.; Larson, Steven M.; Bander, Neil H.; Scher, Howard I.; Morris, Michael J.

    2014-01-01

    Given the bone tropism of prostate cancer, conventional imaging modalities poorly identify or quantify metastatic disease. 89 Zr-huJ591 positron emission tomography (PET) imaging was performed in patients with metastatic prostate cancer to analyze and validate this as an imaging biomarker for metastatic disease. The purpose of this initial study was to assess safety, biodistribution, normal organ dosimetry, and optimal imaging time post-injection for lesion detection. Ten patients with metastatic prostate cancer received 5 mCi of 89 Zr-huJ591. Four whole-body scans with multiple whole-body count rate measurements and serum activity concentration measurements were obtained in all patients. Biodistribution, clearance, and lesion uptake by 89 Zr-huJ591 immuno-PET imaging was analyzed and dosimetry was estimated using MIRD techniques. Initial assessment of lesion targeting of 89 Zr-huJ591 was done. Optimal time for imaging post-injection was determined. The dose was well tolerated with mild chills and rigors seen in two patients. The clearance of 89 Zr-huJ591 from serum was bi-exponential with biological half-lives of 7 ± 4.5 h (range 1.1-14 h) and 62 ± 13 h (range 51-89 h) for initial rapid and later slow phase. Whole-body biological clearance was 219 ± 48 h (range 153-317 h). The mean whole-body and liver residence time was 78.7 and 25.6 h, respectively. Dosimetric estimates to critical organs included liver 7.7 ± 1.5 cGy/mCi, renal cortex 3.5 ± 0.4 cGy/mCi, and bone marrow 1.2 ± 0.2 cGy/mCi. Optimal time for patient imaging after injection was 7 ± 1 days. Lesion targeting of bone or soft tissue was seen in all patients. Biopsies were performed in 8 patients for a total 12 lesions, all of which were histologically confirmed as metastatic prostate cancer. One biopsy-proven lesion was not positive on 89 Zr-huJ591, while the remaining 11 lesions were 89 Zr-huJ591 positive. Two biopsy-positive nodal lesions were noted only on 89 Zr-huJ591 study, while the

  2. {sup 89}Zr-huJ591 immuno-PET imaging in patients with advanced metastatic prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Pandit-Taskar, Neeta; Solomon, Stephen B.; Durack, Jeremy C.; Carrasquillo, Jorge A.; Lefkowitz, Robert A.; Osborne, Joseph R. [Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY (United States); Weill Cornell Medical College, Department of Radiology, New York, NY (United States); O' Donoghue, Joseph A. [Memorial Sloan Kettering Cancer Center, Department of Medical Physics, New York, NY (United States); Beylergil, Volkan; Ruan, Shutian; Cheal, Sarah M. [Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY (United States); Lyashchenko, Serge [Memorial Sloan Kettering Cancer Center, Department of Radiochemistry and Molecular Imaging Probes Core, New York, NY (United States); Gonen, Mithat [Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY (United States); Lewis, Jason S. [Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY (United States); Memorial Sloan Kettering Cancer Center, Department of Radiochemistry and Molecular Imaging Probes Core, New York, NY (United States); Memorial Sloan Kettering Cancer Center, Program in Molecular Pharmacology and Chemistry, New York, NY (United States); Weill Cornell Medical College, Department of Radiology, New York, NY (United States); Holland, Jason P. [Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY (United States); Harvard Medical School, Department of Radiology of Massachusetts General Hospital, Boston, MA (United States); Reuter, Victor E. [Memorial Sloan Kettering Cancer Center, Department of Pathology, New York, NY (United States); Weill Cornell Medical College, Department of Pathology, New York, NY (United States); Loda, Massimo F. [Dana-Farber Cancer Institute, Boston, MA (United States); Broad Institute of Harvard and MIT, Cambridge, MA (United States); Smith-Jones, Peter M. [Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY (United States); Department of Psychiatry and Behavioral Science of Stony Brook University, Stony Brook, NY (United States); Weber, Wolfgang A.; Larson, Steven M. [Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY (United States); Memorial Sloan Kettering Cancer Center, Program in Molecular Pharmacology and Chemistry, New York, NY (United States); Weill Cornell Medical College, Department of Radiology, New York, NY (United States); Bander, Neil H. [Memorial Sloan Kettering Cancer Center, Department of Surgery, New York, NY (United States); Weill Cornell Medical College, Department of Urology, New York, NY (United States); Scher, Howard I.; Morris, Michael J. [Memorial Sloan Kettering Cancer Center, Department of Medicine, New York, NY (United States); Weill Cornell Medical College, Department of Medicine, New York, NY (United States)

    2014-11-15

    Given the bone tropism of prostate cancer, conventional imaging modalities poorly identify or quantify metastatic disease. {sup 89}Zr-huJ591 positron emission tomography (PET) imaging was performed in patients with metastatic prostate cancer to analyze and validate this as an imaging biomarker for metastatic disease. The purpose of this initial study was to assess safety, biodistribution, normal organ dosimetry, and optimal imaging time post-injection for lesion detection. Ten patients with metastatic prostate cancer received 5 mCi of {sup 89}Zr-huJ591. Four whole-body scans with multiple whole-body count rate measurements and serum activity concentration measurements were obtained in all patients. Biodistribution, clearance, and lesion uptake by {sup 89}Zr-huJ591 immuno-PET imaging was analyzed and dosimetry was estimated using MIRD techniques. Initial assessment of lesion targeting of {sup 89}Zr-huJ591 was done. Optimal time for imaging post-injection was determined. The dose was well tolerated with mild chills and rigors seen in two patients. The clearance of {sup 89}Zr-huJ591 from serum was bi-exponential with biological half-lives of 7 ± 4.5 h (range 1.1-14 h) and 62 ± 13 h (range 51-89 h) for initial rapid and later slow phase. Whole-body biological clearance was 219 ± 48 h (range 153-317 h). The mean whole-body and liver residence time was 78.7 and 25.6 h, respectively. Dosimetric estimates to critical organs included liver 7.7 ± 1.5 cGy/mCi, renal cortex 3.5 ± 0.4 cGy/mCi, and bone marrow 1.2 ± 0.2 cGy/mCi. Optimal time for patient imaging after injection was 7 ± 1 days. Lesion targeting of bone or soft tissue was seen in all patients. Biopsies were performed in 8 patients for a total 12 lesions, all of which were histologically confirmed as metastatic prostate cancer. One biopsy-proven lesion was not positive on {sup 89}Zr-huJ591, while the remaining 11 lesions were {sup 89}Zr-huJ591 positive. Two biopsy-positive nodal lesions were noted only on

  3. Characterization of a novel xylanase gene from rumen content of Hu sheep.

    Science.gov (United States)

    Wang, Qian; Luo, Yang; He, Bo; Jiang, Lin-Shu; Liu, Jian-Xin; Wang, Jia-Kun

    2015-12-01

    A novel xylanase gene, xyn-lxy, was cloned from a metagenomic fosmid library, which was previously constructed from the rumen contents of Hu sheep and was functionally characterized in Escherichia coli. The open reading frame was composed of 1923 bp and encoded for 640 amino acids, including a catalytic domain of glycosyl hydrolase family 10 and carbohydrate-binding module 9. The gene showed 97 % identity with uncultured bacterium Contig1552 but low similarity with xylanases from known cellulolytic-degrading microorganisms in the rumen. The recombinant XYN-LXY showed a specific activity of 664.7 U mg(-1). The optimal temperature and pH of the enzyme were 50 °C and 6.0, respectively. Specifically, XYN-LXY was exclusively activated by Mn(2+) among all of the cations and reducing agents tested in this study. An enzymatic hydrolysis assay revealed that XYN-LXY degraded birchwood xylan into xylooligosaccharide with a low degree of polymerization. After incubation for 4 h, the concentration of the dominant product, xylobiose, was 2.297 ± 0.175 mg ml(-1) (74.07 % of total product) followed by xylose with a concentration of 0.656 ± 0.010 mg ml(-1) (21.14 % of total product). The XYN-LXY exhibited deep degradation effects on the xylan substrate, which were rarely observed with endo-xylanase, making it a promising candidate for industrial application, especially in biofuel production.

  4. Feasibility of CBCT-based dose calculation: Comparative analysis of HU adjustment techniques

    International Nuclear Information System (INIS)

    Fotina, Irina; Hopfgartner, Johannes; Stock, Markus; Steininger, Thomas; Lütgendorf-Caucig, Carola; Georg, Dietmar

    2012-01-01

    Background and purpose: The aim of this work was to compare the accuracy of different HU adjustments for CBCT-based dose calculation. Methods and materials: Dose calculation was performed on CBCT images of 30 patients. In the first two approaches phantom-based (Pha-CC) and population-based (Pop-CC) conversion curves were used. The third method (WAB) represents override of the structures with standard densities for water, air and bone. In ROI mapping approach all structures were overridden with average HUs from planning CT. All techniques were benchmarked to the Pop-CC and CT-based plans by DVH comparison and γ-index analysis. Results: For prostate plans, WAB and ROI mapping compared to Pop-CC showed differences in PTV D median below 2%. The WAB and Pha-CC methods underestimated the bladder dose in IMRT plans. In lung cases PTV coverage was underestimated by Pha-CC method by 2.3% and slightly overestimated by the WAB and ROI techniques. The use of the Pha-CC method for head–neck IMRT plans resulted in difference in PTV coverage up to 5%. Dose calculation with WAB and ROI techniques showed better agreement with pCT than conversion curve-based approaches. Conclusions: Density override techniques provide an accurate alternative to the conversion curve-based methods for dose calculation on CBCT images.

  5. Antioxidant and antidermatophytic activities of essential oil and extracts of Metasequoia glyptostroboides Miki ex Hu.

    Science.gov (United States)

    Bajpai, Vivek K; Yoon, Jung In; Chul Kang, Sun

    2009-06-01

    This study was undertaken to assess the antioxidant and antidermatophytic potential of the essential oil and extracts (hexane, chloroform, ethyl acetate and methanol) of Metasequoia glyptostroboides Miki ex Hu. Antioxidant activity was evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The free radical scavenging activities of the oil and ethyl acetate extract were found to be superior (IC(50)=9.1 and 14.24 microg/ml, respectively) as compared to butylatedhydroxyanisole (BHA), (IC(50)=18.27 microg/ml). Also the ethyl acetate extract revealed the highest phenolic contents (93.26 mg/g of dry wt) as compared to the other extracts. Further, oil (1250 microg/disc) and extracts (1750 microg/disc) revealed 35.33-67.66 and 18.0-53.3% antidermatophytic effect, respectively, along with their respective MIC values (62.5-500 and 250-4000 microg/ml) against Trichophyton rubrum KCTC 6345, T. rubrum KCTC 6375, T. rubrum KCTC 6352, T. mentagrophytes KCTC 6085, T. mentagrophytes KCTC 6077, T. mentagrophytes KCTC 6316, Microsporum canis KCTC 6591, M. canis KCTC 6348 and M. canis KCTC 6349. The oil also had a strong detrimental effect on spore germination as well as concentration and time-dependent kinetic inhibition of M. canis KCTC 6591.

  6. La huída en la obra de Mario Vargas Llosa

    Directory of Open Access Journals (Sweden)

    German Arce Ross

    Full Text Available Se trata de poner en perspectiva la mayor parte de novelas de Mario Vargas Llosa en función del tema de la huída, partiendo del hecho que é1 solicitó la nacionalidad Española inmediatamente después de haber perdido las elecciones para la Presidencia del Perú y de haber escrito El pez en el agua. Nuestro análisis intenta demostrar la importancia de la figura paterna – principalmente en el sentido de su ausencia y de sus bruscas reapariciones – en la cristalización sintomática del tema de la fuga. Es por eso que una analogía con la posición fóbica, en relación al padre o a sus substitutos, nos ha parecido pertinente. Teniendo como pivot el análisis de la forma, del contexto y del contenido de su libro de memorias, este trabajo definiría así las bases de una contribución literaria de la obra de Vargas Llosa a la clinica de la fobia.

  7. Systematics of a kleptoplastidal dinoflagellate, Gymnodinium eucyaneum Hu (Dinophyceae), and its cryptomonad endosymbiont.

    Science.gov (United States)

    Xia, Shuang; Zhang, Qi; Zhu, Huan; Cheng, Yingyin; Liu, Guoxiang; Hu, Zhengyu

    2013-01-01

    New specimens of the kleptoplastidal dinoflagellate Gymnodinium eucyaneum Hu were collected in China. We investigated the systematics of the dinoflagellate and the origin of its endosymbiont based on light morphology and phylogenetic analyses using multiple DNA sequences. Cells were dorsoventrally flattened with a sharply acute hypocone and a hemispherical epicone. The confusion between G. eucyaneum and G. acidotum Nygaard still needs to be resolved. We found that the hypocone was conspicuously larger than the epicone in most G. eucyaneum cells, which differed from G. acidotum, but there were a few cells whose hypocone and epicone were of nearly the same size. In addition, there was only one site difference in the partial nuclear LSU rDNA sequences of a sample from Japan given the name G. acidotum and G. eucyaneum in the present study, which suggest that G. eucyaneum may be a synonym of G. acidotum. Spectroscopic analyses and phylogenetic analyses based on nucleomorph SSU rDNA sequences and chloroplast 23 s rDNA sequences suggested that the endosymbiont of G. eucyaneum was derived from Chroomonas (Cryptophyta), and that it was most closely related to C. coerulea Skuja. Moreover, the newly reported kleptoplastidal dinoflagellates G. myriopyrenoides and G. eucyaneum in our study were very similar, and the taxonomy of kleptoplastidal dinoflagellates was discussed.

  8. Systematics of a kleptoplastidal dinoflagellate, Gymnodinium eucyaneum Hu (Dinophyceae, and its cryptomonad endosymbiont.

    Directory of Open Access Journals (Sweden)

    Shuang Xia

    Full Text Available New specimens of the kleptoplastidal dinoflagellate Gymnodinium eucyaneum Hu were collected in China. We investigated the systematics of the dinoflagellate and the origin of its endosymbiont based on light morphology and phylogenetic analyses using multiple DNA sequences. Cells were dorsoventrally flattened with a sharply acute hypocone and a hemispherical epicone. The confusion between G. eucyaneum and G. acidotum Nygaard still needs to be resolved. We found that the hypocone was conspicuously larger than the epicone in most G. eucyaneum cells, which differed from G. acidotum, but there were a few cells whose hypocone and epicone were of nearly the same size. In addition, there was only one site difference in the partial nuclear LSU rDNA sequences of a sample from Japan given the name G. acidotum and G. eucyaneum in the present study, which suggest that G. eucyaneum may be a synonym of G. acidotum. Spectroscopic analyses and phylogenetic analyses based on nucleomorph SSU rDNA sequences and chloroplast 23 s rDNA sequences suggested that the endosymbiont of G. eucyaneum was derived from Chroomonas (Cryptophyta, and that it was most closely related to C. coerulea Skuja. Moreover, the newly reported kleptoplastidal dinoflagellates G. myriopyrenoides and G. eucyaneum in our study were very similar, and the taxonomy of kleptoplastidal dinoflagellates was discussed.

  9. Pathological brain detection based on wavelet entropy and Hu moment invariants.

    Science.gov (United States)

    Zhang, Yudong; Wang, Shuihua; Sun, Ping; Phillips, Preetha

    2015-01-01

    With the aim of developing an accurate pathological brain detection system, we proposed a novel automatic computer-aided diagnosis (CAD) to detect pathological brains from normal brains obtained by magnetic resonance imaging (MRI) scanning. The problem still remained a challenge for technicians and clinicians, since MR imaging generated an exceptionally large information dataset. A new two-step approach was proposed in this study. We used wavelet entropy (WE) and Hu moment invariants (HMI) for feature extraction, and the generalized eigenvalue proximal support vector machine (GEPSVM) for classification. To further enhance classification accuracy, the popular radial basis function (RBF) kernel was employed. The 10 runs of k-fold stratified cross validation result showed that the proposed "WE + HMI + GEPSVM + RBF" method was superior to existing methods w.r.t. classification accuracy. It obtained the average classification accuracies of 100%, 100%, and 99.45% over Dataset-66, Dataset-160, and Dataset-255, respectively. The proposed method is effective and can be applied to realistic use.

  10. Managing Stability in the Taiwan Strait: Non-Military Policy towards Taiwan under Hu Jintao

    Directory of Open Access Journals (Sweden)

    Wu-ueh Chang

    2009-10-01

    Full Text Available China’s Taiwan policy has been one of coupling intimidation (the “stick” approach with coercion (the “carrot” approach, a policy mix which, in the near term, is not likely to change, as is evidenced by the passage of the “Anti-Secession Law” in March, 2005. However, under Hu Jintao, the focus has been on pragmatism. The warm atmosphere that presently reigns in the Taiwan Strait area is unprecedented. Further talks are expected before the two cross-Strait leaders are slated to step down, simultaneously, in 2012. An era of reconciliation and negotiations has dawned. For the first time there is consensus regarding norms of interaction between the two sides. Cross-Strait relations have stabilized after years of tumult. More open, stable and predictable cross-Strait relations are in the interests of both sides. Difficulties surely lie ahead, but they will be dealt with in a different manner than what has been witnessed in the past.

  11. [The vitalism of Paul-Joseph Barthez (1734-1806)].

    Science.gov (United States)

    Han, Hee Jin

    2010-06-30

    In The Logic of Life (1970), Francois Jacob (1920- ), Nobel Prize laureate in Physiology or Medicine (1965), proclaimed the end of vitalism based on the concept of life. More than two decades before this capital sentence condemning vitalism was pronounced, Georges Canguilhem (1904-1995), a French philosopher of medicine, already acknowledged that eighteenth-century vitalism was scientifically retrograde and politically reactionary or counter-revolutionary insofar as it was rooted in the animism of Georg Ernst Stahl (1660-1734). The negative preconception of the term 'vitalism' came to be established as an orthodox view, since Claude Bernard (1813-1878) unfairly criticized contemporary vitalism in order to propagate his idea of experimental medicine. An eminent evolutionary biologist like Ernst Mayr (1904-2005) still defended similar views in This is Biology (1997), arguing that if vitalists were decisive and convincing in their rejection of the Cartesian model (negative heuristics), however they were equally indecisive and unconvincing in their own explanatory endeavors (positive heuristics). Historically speaking, vitalists came to the forefront for their outstanding criticism of Cartesian mechanism and physicochemical reductionism, while their innovative concepts and theories were underestimated and received much less attention. Is it true that vitalism was merely a pseudo-science, representing a kind of romanticism or mysticism in biomedical science? Did vitalists lack any positive heuristics in their biomedical research? Above all, what was actually the so.called 'vitalism'? This paper aims to reveal the positive heuristics of vitalism defined by Paul.Joseph Barthez (1734-1806) who was the founder of the vitalist school of Montpellier. To this end, his work and idea are introduced with regard to the vying doctrines in physiology and medicine. At the moment when he taught at the medical school of Montpellier, his colleagues advocated the mechanism of Rene

  12. The Ambiguity of Justice: Paul Ricoeur on Universalism and Evil

    Directory of Open Access Journals (Sweden)

    Geoffrey Dierckxsens

    2016-01-01

    Full Text Available In this article I will examine Ricœur’s idea of the universal in his understanding of justice. Scholars recently discussed the extent to which Ricœur understands universal moral norms and universal rules of justice in his anthropology of human action (e.g., J. Michel, Paul Ricœur: une philosophie de l’agir humain, Paris: Les Éditions du Cerf, 2006, and argue that Ricœur stresses too much the idea of universal moral norms with regard to cultural and moral diversity (e.g., G. H. Taylor, “Ricoeur versus Ricoeur? Between the Universal and the Contextual,” From Ricoeur to Action. The Socio-Political Significance of Ricoeur’s Thinking, Todd S. Mei and David Lewin (eds., (London and New York: Bloomsbury, 2012. G. H. Taylor, “Reenvisioning Justice,” Lo Squarda 12 (2013: 65-80. In this article I will take part in the debate about universalism and approach Ricœur’s idea of the universal from a different angle, in placing it in light of his idea of evil. The point I will aim to make in this article is that Ricœur’s idea of the relation between justice and evil demonstrates what I understand as the ambiguity of justice, which highlights the difficulty of defining universal rules of justice. I will argue that this ambiguity is the following: justice aims at the establishment of social peace and in that sense it is the necessary remedy against human evil, but justice also implies power, and possibly violence, over others in that it relates to violent feelings of vengeance, to institutional mechanism of authority, and to a struggle of values. Yet if rules of justice relate to evil in the sense of power over others, so I argue, then it is problematic to define absolute criteria for rules of justice, i.e., for rules for social peace: because justice relates to particular values, which means that the risk of violence is inherent to institutional rules of justice, there is no ultimate universal set of such rules. This article therefore

  13. Paul Trap Simulator Experiment (PTSX) to simulate intense beam propagation through a periodic focusing quadrupole field

    International Nuclear Information System (INIS)

    Davidson, Ronald C.; Efthimion, Philip C.; Gilson, Erik; Majeski, Richard; Qin, Hong

    2002-01-01

    The Paul Trap Simulator Experiment (PTSX) is under construction at the Princeton Plasma Physics Laboratory to simulate intense beam propagation through a periodic quadrupole magnetic field. In the Paul trap configuration, a long nonneutral plasma column is confined axially by dc voltages on end cylinders at z=+L and z=-L, and transverse confinement is provided by segmented cylindrical electrodes with applied oscillatory voltages ±V 0 (t) over 90 deg. segments. Because the transverse focusing force is similar in waveform to that produced by a discrete set of periodic quadrupole magnets in a frame moving with the beam, the Paul trap configuration offers the possibility of simulating intense beam propagation in a compact laboratory facility. The experimental layout is described, together with the planned experiments to study beam mismatch, envelope instabilities, halo particle production, and collective wave excitations

  14. Paul Trap Simulator Experiment (PTSX) to simulate intense beam propagation through a periodic focusing quadrupole field

    Science.gov (United States)

    Davidson, Ronald C.; Efthimion, Philip C.; Gilson, Erik; Majeski, Richard; Qin, Hong

    2002-01-01

    The Paul Trap Simulator Experiment (PTSX) is under construction at the Princeton Plasma Physics Laboratory to simulate intense beam propagation through a periodic quadrupole magnetic field. In the Paul trap configuration, a long nonneutral plasma column is confined axially by dc voltages on end cylinders at z=+L and z=-L, and transverse confinement is provided by segmented cylindrical electrodes with applied oscillatory voltages ±V0(t) over 90° segments. Because the transverse focusing force is similar in waveform to that produced by a discrete set of periodic quadrupole magnets in a frame moving with the beam, the Paul trap configuration offers the possibility of simulating intense beam propagation in a compact laboratory facility. The experimental layout is described, together with the planned experiments to study beam mismatch, envelope instabilities, halo particle production, and collective wave excitations.

  15. New perspectives on approximation and sampling theory Festschrift in honor of Paul Butzer's 85th birthday

    CERN Document Server

    Schmeisser, Gerhard

    2014-01-01

    Paul Butzer, who is considered the academic father and grandfather of many prominent mathematicians, has established one of the best schools in approximation and sampling theory in the world. He is one of the leading figures in approximation, sampling theory, and harmonic analysis. Although on April 15, 2013, Paul Butzer turned 85 years old, remarkably, he is still an active research mathematician. In celebration of Paul Butzer’s 85th birthday, New Perspectives on Approximation and Sampling Theory is a collection of invited chapters on approximation, sampling, and harmonic analysis written by students, friends, colleagues, and prominent active mathematicians. Topics covered include approximation methods using wavelets, multi-scale analysis, frames, and special functions. New Perspectives on Approximation and Sampling Theory requires basic knowledge of mathematical analysis, but efforts were made to keep the exposition clear and the chapters self-contained. This volume will appeal to researchers and graduate...

  16. Supplier evaluation system of the wood processing enterprise in the region of the CZ, SK, HU and AT

    OpenAIRE

    Muselíková, Vladislava

    2015-01-01

    The Bachelor thesis Supplier evaluation system of the wood processing enterprise in the region of the CR, the SK, HU and AT deals with the analysis of the current supplier evaluation system in IKEA Industry company in Malacky. The theoretical part is based on literature review and contains a description of the purchasing process and methodology for selection and evaluation of suppliers. The practical part is devoted to the analysis of the Supplier Classification in IKEA. The main output of th...

  17. HTLV-1 Infection and Neuropathogenesis in the Context of Rag1-/-γc-/- (RAG1-Hu) and BLT Mice.

    Science.gov (United States)

    Ginwala, Rashida; Caruso, Breanna; Khan, Zafar K; Pattekar, Ajinkya; Chew, Glen M; Corley, Michael J; Loonawat, Ronak; Jacobson, Steven; Sreedhar, Sreesha; Ndhlovu, Lishomwa C; Jain, Pooja

    2017-09-01

    To date, the lack of a suitable small animal model has hindered our understanding of Human T-cell lymphotropic virus (HTLV)-1 chronic infection and associated neuropathogenesis defined as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The host immune response plays a critical role in the outcome of HTLV-1 infection, which could be better tested in the context of humanized (hu) mice. Thus, we employ here the Balb/c-Rag1 -/- γc -/- or Rag1 as well as Bone marrow-Liver-Thymic (BLT) mouse models for engraftment of human CD34 + hematopoietic stem cells. Flow cytometry and histological analyses confirmed reconstitution of Rag1 and BLT mice with human immune cells. Following HTLV-1 infection, proviral load (PVL) was detected in the blood of Rag-1 and BLT hu-mice as early as 2 weeks post-infection (wpi) with sustained elevation in the subsequent weeks followed by Tax expression. Additionally, infection was compared between adult and neonatal Rag1 mice with both PVL and Tax expression considerably higher in the adult Rag1 mice as compared to the neonates. Establishment of peripheral infection led to lymphocytic infiltration with concomitant Tax expression and resulting myelin disruption within the central nervous system of infected mice. In addition, up-regulation in the expression of several immune checkpoint mediators such as programmed cell death-1 (PD-1), T-cell Ig and ITIM domain (TIGIT), and T cell Ig and mucin domain-3 protein (Tim-3) were observed on CD8 + T cells in various organs including the CNS of infected hu-mice. Collectively, these studies represent the first attempt to establish HTLV-1 neuropathogenesis in the context of Rag-1 and BLT hu-mice as potential novel tools for understanding HTLV-1 neuropathogenesis and testing of novel therapies such as immune checkpoint blockade in the amelioration of chronic HTLV-1 infection.

  18. Tra stabilità sociale e pornografia: giochi di parole sovversivi e armonizzazione su Internet nell’era Hu Jintao

    Directory of Open Access Journals (Sweden)

    Nazarena Fazzari

    2017-07-01

    Full Text Available The purpose of this paper is to analyze the policies adopted by the government of Hu Jintao (2002-2012 about the Internet. Such laws have been partially translated into Italian. Their aim alternates between the fight against pornography and the protection of social stability. The ‘digital resistance’ attempts to evade censorship through homophony, e.g. through the Baidu ten mythical creatures, the most famous being Caonima.

  19. HuD and the Survival Motor Neuron Protein Interact in Motoneurons and Are Essential for Motoneuron Development, Function, and mRNA Regulation.

    Science.gov (United States)

    Hao le, Thi; Duy, Phan Q; An, Min; Talbot, Jared; Iyer, Chitra C; Wolman, Marc; Beattie, Christine E

    2017-11-29

    Motoneurons establish a critical link between the CNS and muscles. If motoneurons do not develop correctly, they cannot form the required connections, resulting in movement defects or paralysis. Compromised development can also lead to degeneration because the motoneuron is not set up to function properly. Little is known, however, regarding the mechanisms that control vertebrate motoneuron development, particularly the later stages of axon branch and dendrite formation. The motoneuron disease spinal muscular atrophy (SMA) is caused by low levels of the survival motor neuron (SMN) protein leading to defects in vertebrate motoneuron development and synapse formation. Here we show using zebrafish as a model system that SMN interacts with the RNA binding protein (RBP) HuD in motoneurons in vivo during formation of axonal branches and dendrites. To determine the function of HuD in motoneurons, we generated zebrafish HuD mutants and found that they exhibited decreased motor axon branches, dramatically fewer dendrites, and movement defects. These same phenotypes are present in animals expressing low levels of SMN, indicating that both proteins function in motoneuron development. HuD binds and transports mRNAs and one of its target mRNAs, Gap43 , is involved in axonal outgrowth. We found that Gap43 was decreased in both HuD and SMN mutants. Importantly, transgenic expression of HuD in motoneurons of SMN mutants rescued the motoneuron defects, the movement defects, and Gap43 mRNA levels. These data support that the interaction between SMN and HuD is critical for motoneuron development and point to a role for RBPs in SMA. SIGNIFICANCE STATEMENT In zebrafish models of the motoneuron disease spinal muscular atrophy (SMA), motor axons fail to form the normal extent of axonal branches and dendrites leading to decreased motor function. SMA is caused by low levels of the survival motor neuron (SMN) protein. We show in motoneurons in vivo that SMN interacts with the RNA binding

  20. Recovering Philosophy as the Love of Wisdom: A Contribution of St. John Paul II

    Directory of Open Access Journals (Sweden)

    Pawel Tarasiewicz

    2016-03-01

    Full Text Available The article aims at demonstrating that, by his teaching on human person and his action, St. John Paul II (also known as Karol Wojtyła implicitly contributed to a resolution of the most serious problem of contemporary philosophy, which consists in separating wisdom from love and substituting wisdom with understanding or knowledge. The author concludes that John Paul II makes a persuasive contribution to recover philosophy as the love of wisdom by (1 identifying truth in the area of freedom, self-fulfillment and conscience, and (2 appealing to man’s honesty and happiness.

  1. A Conjugated Aptamer-Gold Nanoparticle Fluorescent Probe for Highly Sensitive Detection of rHuEPO-α

    Directory of Open Access Journals (Sweden)

    Zhaoyang Zhang

    2011-11-01

    Full Text Available We present here a novel conjugated aptamer-gold nanoparticle (Apt-AuNPs fluorescent probe and its application for specific detection of recombinant human erythropoietin-α (rHuEPO-α. In this nanobiosensor, 12 nm AuNPs function as both a nano-scaffold and a nano-quencher (fluorescent energy acceptor, on the surface of which the complementary sequences are linked (as cODN-AuNPs and pre-hybridized with carboxymethylfluorescein (FAM-labeled anti-rHuEPO-α aptamers. Upon target protein binding, the aptamers can be released from the AuNP surface and the fluorescence signal is restored. Key variables such as the length of linker, the hybridization site and length have been designed and optimized. Full performance evaluation including sensitivity, linear range and interference substances are also described. This nanobiosensor provides a promising approach for a simple and direct quantification of rHuEPO-α concentrations as low as 0.92 nM within a few hours.

  2. Comment on "Tropospheric temperature response to stratospheric ozone recovery in the 21st century" by Hu et al. (2011

    Directory of Open Access Journals (Sweden)

    C. McLandress

    2012-03-01

    Full Text Available In a recent paper Hu et al. (2011 suggest that the recovery of stratospheric ozone during the first half of this century will significantly enhance free tropospheric and surface warming caused by the anthropogenic increase of greenhouse gases, with the effects being most pronounced in Northern Hemisphere middle and high latitudes. These surprising results are based on a multi-model analysis of CMIP3 model simulations with and without prescribed stratospheric ozone recovery. Hu et al. suggest that in order to properly quantify the tropospheric and surface temperature response to stratospheric ozone recovery, it is necessary to run coupled atmosphere-ocean climate models with stratospheric ozone chemistry. The results of such an experiment are presented here, using a state-of-the-art chemistry-climate model coupled to a three-dimensional ocean model. In contrast to Hu et al., we find a much smaller Northern Hemisphere tropospheric temperature response to ozone recovery, which is of opposite sign. We suggest that their result is an artifact of the incomplete removal of the large effect of greenhouse gas warming between the two different sets of models.

  3. HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP

    Science.gov (United States)

    Noh, Ji Heon; Kim, Kyoung Mi; Abdelmohsen, Kotb; Yoon, Je-Hyun; Panda, Amaresh C.; Munk, Rachel; Kim, Jiyoung; Curtis, Jessica; Moad, Christopher A.; Wohler, Christina M.; Indig, Fred E.; de Paula, Wilson; Dudekula, Dawood B.; De, Supriyo; Piao, Yulan; Yang, Xiaoling; Martindale, Jennifer L.; de Cabo, Rafael; Gorospe, Myriam

    2016-01-01

    Some mitochondrial long noncoding RNAs (lncRNAs) are encoded by nuclear DNA, but the mechanisms that mediate their transport to mitochondria are poorly characterized. Using affinity RNA pull-down followed by mass spectrometry analysis, we found two RNA-binding proteins (RBPs), HuR (human antigen R) and GRSF1 (G-rich RNA sequence-binding factor 1), that associated with the nuclear DNA-encoded lncRNA RMRP and mobilized it to mitochondria. In cultured human cells, HuR bound RMRP in the nucleus and mediated its CRM1 (chromosome region maintenance 1)-dependent export to the cytosol. After RMRP was imported into mitochondria, GRSF1 bound RMRP and increased its abundance in the matrix. Loss of GRSF1 lowered the mitochondrial levels of RMRP, in turn suppressing oxygen consumption rates and modestly reducing mitochondrial DNA replication priming. Our findings indicate that RBPs HuR and GRSF1 govern the cytoplasmic and mitochondrial localization of the lncRNA RMRP, which is encoded by nuclear DNA but has key functions in mitochondria. PMID:27198227

  4. Publicidad y consumo de alimentos en estudiantes de Huánuco (Perú

    Directory of Open Access Journals (Sweden)

    María Luisa Sevillano García

    2012-10-01

    Full Text Available Las importantes carencias nutritivas apreciadas en estudiantes del distrito de Huánuco (Perú, junto con la publicidad televisiva de productos de dudosa calidad nutricional observada, nos llevó a plantear y desarrollar una investigación con el objeto de analizar la relación entre ambos fenómenos titulada: Influencia de los anuncios televisivos en el consumo de alimentos publicitados durante el 2010, cuyo resumen se presenta en este artículo. En la investigación planteamos un estudio correlacional con una muestra de 120 escolares de diversas instituciones educativas, a quienes se aplicaron satisfactoriamente encuestas, entrevistas y guía de evaluación física; también se analizó la publicidad emitida por los canales de televisión sobre alimentos y su contenido nutricional. El análisis inferencial aplicado fue Ji cuadrado (?2. Con esta investigación se ha demostrado que el estado de salud de los escolares está afectado, siendo muy agudo respecto a la caries dental, problema que se atribuye al consumo de ciertos alimentos. Se constata que existe relación positiva, con alta significancia estadística, entre la adherencia a los anuncios televisivos y el consumo de alimentos publicitados de alto contenido en sodio, calcio, azúcar y de calorías por los escolares estudiados; así mismo, se prueba la interdependencia entre la exposición a los anuncios televisivos y el consumo de alimentos con productos de alto contenido en grasa que merecen ser vigilados y controlados por los responsables.

  5. ZASTOSOWANIE FUNKCJONAŁU HU-WASHIZU W PLASTYCZNEJ ANALIZIE MES PŁYT GRUBYCH

    Directory of Open Access Journals (Sweden)

    Jakub LEWANDOWSKI

    2016-07-01

    Full Text Available W pracy sformułowano oryginalny, autorski funkcjonał dla zagadnień teorii plastyczności. Podstawą był funkcjonał Hu-Washizu z teorii sprężystości. Przyrostowa postać funkcjonału pozwala w prosty sposób budować algorytmy MES. Zastosowanie funkcjonału przedstawiono na przykładzie płyty grubej. Zastosowano model warstwowy aby uwzględnić częściowe uplastycznienie przekroju płyty. Algorytm MES dla płyty grubej zbudowano w oparciu o trójkątny trzy węzłowy element skończony z liniowymi funkcjami kształtu dla wszystkich przemieszczeń uogólnionych. Naprężenia i odkształcenia w tego typu elemencie przyjmuje się jako stałe. Przedstawiony algorytm nie wymaga żadnych dodatkowych równań teorii plastyczności i jest równoważny stowarzyszonemu prawu płynięcia plastycznego. Algorytm prowadzi do nieliniowego, przyrostowego układu równań algebraicznych, który rozwiązuje się metodą Newtona. Kilka prostych przykładów pozytywnie weryfikuje przyjęte założenia i stosowane algorytmy.

  6. Effects of Bai-Hu decoction on fever induced by lipopolysaccharide

    Directory of Open Access Journals (Sweden)

    Li-Long Jia

    2013-03-01

    Full Text Available This study was designed to investigate the antifebrile effect and mechanisms of Bai-Hu decoction (BHD, a traditional Chinese medical (TCM prescription. The rabbits used in this study received an intravenous injection of lipopolysaccharide (LPS after being orally administered with BHD, ibuprofen, or saline, and their rectal temperatures were monitored by a copper–constantan thermocouple. Concentrations of interleukin-1 beta (IL-1β and tumor necrosis factor alpha (TNF-α in serum and hypothalamus were assayed using the commercially available rabbit IL-1β and TNF-α enzyme-linked immunosorbent assay kits following the manufacturer’s instructions. The BHD treatment group exhibited a significant fall in body temperature in both peaks compared with the LPS group (p<0.05. BHD reduced the concentrations of IL-1β and TNF-α in serum, and of TNF-α in hypothalamus to control the febrile responses at 1 hour. Besides the levels of IL-1β in hypothalamus and serum, the concentration of TNF-α in hypothalamus was decreased remarkably in the BHD group than in the LPS group at 3 hours. The main findings, the partial mechanisms of BHD in reducing biphasic fever elicited by LPS, were that treatments with the crude extract of BHD could remarkably reduce the increased concentrations of IL-1β and TNF-α, not only in serum but also in hypothalamus. The results indicated that BHD would be a valuable candidate for further investigation as a traditional antifebrile and anti-inflammatory natural drug.

  7. Critical experiments on low-enriched uranium oxide system with H/U=1.25

    International Nuclear Information System (INIS)

    Oh, I.; Rothe, R.E.; Tuck, G.

    1982-01-01

    Fifteen (15) critical experiments were performed on a horizontal split table machine using 4.48%-enriched sup(235)U uranium oxide(U 3 O 8 ). The oxide was compacted to a density of 4.68g/cm 3 and placed in 152 mm cubical aluminum cans. Water was added to achive an H/U of 1.25. Various arrays of oxide cans were distributed on each half of the split table, and the separation between halves reduced until criticality occurred. The critical table separation varied from 3.59 mm to 18.40 mm. Twelve (12) experiments required the addition of a high-enriched(-93 %sup(235)U) metal or solution driver to achieve criticality. These experiments were performed in a plastic, concrete, or thin steel reflector. Three additional experiments in the plastic reflector contained either 9.3-mm- or 24.3-mm-thick plastic moderator material between the oxide cans and did not require a driver to achieve criticality. Critical uranium driver masses ranged from 9.999 kg to 14.000 kg (solution driver), and from 25.378 kg to 29.278 kg (metal driver) for 5X5X5 arrays of uranium oxide cans. Always, one or four of these 125 cans had to be removed to make room for the drivers. Therefore, the uranium oxide masses used were 1823.8 kg and 1863.5 kg. For the moderated experiments, the uranium oxide mass ranged between 574.4 kg and 1210.0 kg. (Author)

  8. 76 FR 1532 - Determinations of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur...

    Science.gov (United States)

    2011-01-11

    ... of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur/Douglas PM 10... making final determinations that the Hayden, Nogales, and Paul Spur/Douglas nonattainment areas in... the Clean Air Act, that three Arizona ``moderate'' PM 10 nonattainment areas (Hayden, Nogales, and...

  9. 75 FR 67220 - Determinations of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur...

    Science.gov (United States)

    2010-11-02

    ... of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur/Douglas PM 10...: EPA has determined that the Hayden, Nogales, and Paul Spur/ Douglas nonattainment areas in Arizona... of a review of more recent ambient monitoring data, EPA has determined that the Hayden, Nogales, and...

  10. 75 FR 72964 - Determinations of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur...

    Science.gov (United States)

    2010-11-29

    ... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 [R09-OAR-2010-0718; FRL-9233-1] Determinations of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur/Douglas PM10 Nonattainment... November 2, 2010 (75 FR 67220), direct final rule determining that the Hayden, Nogales, and Paul Spur...

  11. HuMiTar: A sequence-based method for prediction of human microRNA targets

    Directory of Open Access Journals (Sweden)

    Chen Ke

    2008-12-01

    Full Text Available Abstract Background MicroRNAs (miRs are small noncoding RNAs that bind to complementary/partially complementary sites in the 3' untranslated regions of target genes to regulate protein production of the target transcript and to induce mRNA degradation or mRNA cleavage. The ability to perform accurate, high-throughput identification of physiologically active miR targets would enable functional characterization of individual miRs. Current target prediction methods include traditional approaches that are based on specific base-pairing rules in the miR's seed region and implementation of cross-species conservation of the target site, and machine learning (ML methods that explore patterns that contrast true and false miR-mRNA duplexes. However, in the case of the traditional methods research shows that some seed region matches that are conserved are false positives and that some of the experimentally validated target sites are not conserved. Results We present HuMiTar, a computational method for identifying common targets of miRs, which is based on a scoring function that considers base-pairing for both seed and non-seed positions for human miR-mRNA duplexes. Our design shows that certain non-seed miR nucleotides, such as 14, 18, 13, 11, and 17, are characterized by a strong bias towards formation of Watson-Crick pairing. We contrasted HuMiTar with several representative competing methods on two sets of human miR targets and a set of ten glioblastoma oncogenes. Comparison with the two best performing traditional methods, PicTar and TargetScanS, and a representative ML method that considers the non-seed positions, NBmiRTar, shows that HuMiTar predictions include majority of the predictions of the other three methods. At the same time, the proposed method is also capable of finding more true positive targets as a trade-off for an increased number of predictions. Genome-wide predictions show that the proposed method is characterized by 1.99 signal

  12. DNA clasping by mycobacterial HU: the C-terminal region of HupB mediates increased specificity of DNA binding.

    Directory of Open Access Journals (Sweden)

    Sandeep Kumar

    Full Text Available BACKGROUND: HU a small, basic, histone like protein is a major component of the bacterial nucleoid. E. coli has two subunits of HU coded by hupA and hupB genes whereas Mycobacterium tuberculosis (Mtb has only one subunit of HU coded by ORF Rv2986c (hupB gene. One noticeable feature regarding Mtb HupB, based on sequence alignment of HU orthologs from different bacteria, was that HupB(Mtb bears at its C-terminal end, a highly basic extension and this prompted an examination of its role in Mtb HupB function. METHODOLOGY/PRINCIPAL FINDINGS: With this objective two clones of Mtb HupB were generated; one expressing full length HupB protein (HupB(Mtb and another which expresses only the N terminal region (first 95 amino acid of hupB (HupB(MtbN. Gel retardation assays revealed that HupB(MtbN is almost like E. coli HU (heat stable nucleoid protein in terms of its DNA binding, with a binding constant (K(d for linear dsDNA greater than 1000 nM, a value comparable to that obtained for the HUalphaalpha and HUalphabeta forms. However CTR (C-terminal Region of HupB(Mtb imparts greater specificity in DNA binding. HupB(Mtb protein binds more strongly to supercoiled plasmid DNA than to linear DNA, also this binding is very stable as it provides DNase I protection even up to 5 minutes. Similar results were obtained when the abilities of both proteins to mediate protection against DNA strand cleavage by hydroxyl radicals generated by the Fenton's reaction, were compared. It was also observed that both the proteins have DNA binding preference for A:T rich DNA which may occur at the regulatory regions of ORFs and the oriC region of Mtb. CONCLUSIONS/SIGNIFICANCE: These data thus point that HupB(Mtb may participate in chromosome organization in-vivo, it may also play a passive, possibly an architectural role.

  13. miR-29b, miR-205 and miR-221 enhance chemosensitivity to gemcitabine in HuH28 human cholangiocarcinoma cells.

    Directory of Open Access Journals (Sweden)

    Kinya Okamoto

    Full Text Available BACKGROUND AND AIMS: Cholangiocarcinoma (CCA is highly resistant to chemotherapy, including gemcitabine (Gem treatment. MicroRNAs (miRNAs are endogenous, non-coding, short RNAs that can regulate multiple genes expression. Some miRNAs play important roles in the chemosensitivity of tumors. Here, we examined the relationship between miRNA expression and the sensitivity of CCA cells to Gem. METHODS: Microarray analysis was used to determine the miRNA expression profiles of two CCA cell lines, HuH28 and HuCCT1. To determine the effect of candidate miRNAs on Gem sensitivity, expression of each candidate miRNA was modified via either transfection of a miRNA mimic or transfection of an anti-oligonucleotide. Ontology-based programs were used to identify potential target genes of candidate miRNAs that were confirmed to affect the Gem sensitivity of CCA cells. RESULTS: HuCCT1 cells were more sensitive to Gem than were HuH28 cells, and 18 miRNAs were differentially expressed whose ratios over ± 2log2 between HuH28 and HuCCT1. Among these 18 miRNAs, ectopic overexpression of each of three downregulated miRNAs in HuH28 (miR-29b, miR-205, miR-221 restored Gem sensitivity to HuH28. Suppression of one upregulated miRNA in HuH28, miR-125a-5p, inhibited HuH28 cell proliferation independently to Gem treatment. Selective siRNA-mediated downregulation of either of two software-predicted targets, PIK3R1 (target of miR-29b and miR-221 or MMP-2 (target of miR-29b, also conferred Gem sensitivity to HuH28. CONCLUSIONS: miRNA expression profiling was used to identify key miRNAs that regulate Gem sensitivity in CCA cells, and software that predicts miRNA targets was used to identify promising target genes for anti-tumor therapies.

  14. Passings to note: Paul Michael Packman, MD; S. Charles Schulz, MD.

    Science.gov (United States)

    Black, Donald W

    2018-02-01

    One of the keys to the success of Annals of Clinical Psychiatry has always been the tireless efforts of our dedicated Editorial Board. We recently lost 2 longtime Editorial Board members, Drs. Paul Michael Packman and S. Charles Schulz. Both will be greatly missed.

  15. A School-Based Enterprise: The Saint Pauls, North Carolina Experience.

    Science.gov (United States)

    Paquin, Thomas F.

    1991-01-01

    The superintendent of Saint Pauls Schools describes how educators, community leaders, businesspersons, and high school students worked together to develop the Way Off Broadway Deli, a successful school-based enterprise providing experiential education in entrepreneurship and small business management, as well as student employment and local…

  16. Paul Henry Latimer (1925-2011): discoverer of selective scattering in photosynthetic systems.

    Science.gov (United States)

    Latimer, Margaret Gwyn; Bannister, Thomas T; Govindjee

    2017-10-01

    We provide here a brief tribute to Paul Henry Latimer (November 25, 1925 to October 1, 2011), a dedicated biological physicist, discoverer of selective scattering in biological systems, a wonderful teacher, husband, and father. We provide here a glimpse of his personal and professional life, including reminiscences from F. Dudley Bryant, Dan A. Cross, Bobby E. Pyle, Bryan L. Seiber, and Bruce A. Seiber.

  17. Resurrecting Democracies : Secularity Recast in Charles Taylor, Paul Valadier, and Joseph Ratzinger

    NARCIS (Netherlands)

    Ossewaarde-Lowtoo, Roshnee

    In this article, the alternative conception of secularity of Charles Taylor, Paul Valadier and Joseph Ratzinger (former Benedict XVI) is explored. A secularized society, which they take as an established condition, does not necessarily exclude religion, Christianity or Christian transcendence, in

  18. Dokumentaalselt tõestatud: Paul Keresel suleti tee maailmameistri tiitlile / Paavo Kivine

    Index Scriptorium Estoniae

    Kivine, Paavo, 1939-

    2015-01-01

    Miks neli aastakümmet tipus püsinud suurmeister ei tulnud maailmameistriks. Lisatud dokument on pöördumine Venemaa Kommunistliku Partei II sekretäri ülesandeid täitnud Andrei Ždanovi poole ettepanekuga lubada Paul Keresel osaleda 1947. aasta maailmameistrivõistlustel (foto venekeelsest dokumendist ja tõlge)

  19. Guest blog: Jacob Davidsen and Paul McIlvenny on Experiments with Big Video

    DEFF Research Database (Denmark)

    Davidsen, Jacob; Mcilvenny, Paul Bruce

    2016-01-01

    How good are your video records? One angle? Two? Wide-angle? Was the camera static or did you move to catch things – and miss other things? How good was the sound? All of us have occasionally been frustrated with what we find on the screen when we come to analyse it, but Jacob Davidsen and Paul M...

  20. Inquiry and Irony: Promise and Paradox in Paul Jablon's "The Synergy of Inquiry"

    Science.gov (United States)

    Nurenberg, David

    2016-01-01

    Paul Jablon's "The Synergy of Inquiry" (2014) is well-timed. The 2014 deadline set by No Child Left Behind (NCLB, 2002) for universal student proficiency has come and gone, and according to the National Assessment of Educational Progress, "proficiency rates last year were below 50 percent for nearly every racial and ethnic group, in…

  1. Elagu eesti energia : Jaan ja Jüri Ojaver, Paul Rodgers / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    2001-01-01

    Paul Rodgersi, Jüri ja Jaan Ojaveri ühisnäitusest "Koostöö" Rakvere Kesklinna galeriis. P. Rodgersilt ja Jüri Ojaverilt on väljas Viinist "Eesti energia" näituselt naasnud tööd, Jaan Ojaverilt minimalistlikud tööriistad-objektid

  2. Hindemith, Paul: "Complete sonatas for Solo Instrument and Piano" / Michel Roubinet

    Index Scriptorium Estoniae

    Roubinet, Michel

    1997-01-01

    Uuest heliplaadist "Hindemith, Paul: "Complete sonatas for Solo Instrument and Piano", vol. 6. Sonate pour trompette et piano. Sonates pour orgue nos 1 a 3. Sonate pour cor et piano. Ensemble Villa Musica: Kalle Randalu (piano)" MDG "Gold" 304 0696-2, distr. Media 7 (CD:160F)

  3. Paul Broca and French Brains: Portraits from the Life of an Eminent Neuroscientist

    Science.gov (United States)

    LaPointe, Leonard L.

    2014-01-01

    Pierre Paul Broca is one of the most legendary neuroscientists of the last few centuries. His name graces a region of the brain, and his work is richly associated with human communication and its disorders. This article traces the contributions of this man and the historical context of his remarkable discoveries. After approval to visit and access…

  4. REvISITING PAul'S PARAdIGMATIC, SElf-CRITICAl REMARkS IN 1 ...

    African Journals Online (AJOL)

    However, in 1 Corinthians 15:8-10 Paul openly admits about being in error in the past ..... Much has been written about the expression e[ktrwma in verse 8. This .... Collins 2008:120- .... The Gospel of John in cultural and rhetorical perspective.

  5. Paul of Aegina (ca 625-690 ad), Reconstructing Male Gynecomastia.

    Science.gov (United States)

    Tsoucalas, Gregory; Sgantzos, Markos

    2017-06-01

    Paul of Aegina thrived with his innovative operations, practically creating a kind of a new surgical school. He had deeply believed in human's body perfection introducing a series of cosmetic operations. Among them stood the male's breasts reconstruction in the case of pseudo-gynecomastia. His intervention was replicated by both the western Europeans and the Arabs.

  6. Paul Abraham: A Forgotten Scholar of the Prussian Academy of Sciences and Humanities

    Science.gov (United States)

    Thiel, Jens

    2004-01-01

    Paul Abraham, one of the Berlin Academy's most experienced researchers, was deported to Auschwitz in 1943. The fate of this Jewish scholar reveals much about the inner life of the Academy, and its treatment of Jewish staff, during the World War II. This paper describes his life, against a backdrop of war, revolution, and dictatorship, and in the…

  7. Swiss synchrotron light source at the Paul Scherrer Institute at Villigen

    International Nuclear Information System (INIS)

    1996-02-01

    The brochure describes the Swiss project for a synchrotron light source to be built at the Paul Scherrer Institute at Villigen. According to the project the synchrotron light source shall be realized up to the year 2001 at costs of 165 Million Swiss Francs. figs., tabs

  8. 200 Paul and Hard Work (2 Thessalonians 3:6-10): A Christian ...

    African Journals Online (AJOL)

    the developmental conditions in the land and such is the endeavour of this work as Paul's ... intellectual works, articulation of ethical principles, religion, politics and trade. Thus, the .... avoid any loafer in the system because such were walking in disorder, τάκτως .... mine) Africans and other such parts of the world. Ejiogu in ...

  9. Boundaries - US Army Corps of Engineers - St. Paul District (MVP) Civil Works

    Data.gov (United States)

    Army Corps of Engineers, Department of the Army, Department of Defense — The US Army Corps of Engineers - St. Paul District Civil Works boundary. Boundary is based on 1:24k watershed data and coordination with MVR to determine shared...

  10. Excerpts from Vatican's "Veritatis Splendor," Pope John Paul II's Views of Moral Truth.

    Science.gov (United States)

    Chronicle of Higher Education, 1993

    1993-01-01

    Excerpts are presented from a recent papal encyclical that sets forth John Paul II's views on timeless moral truths and on dissent from them within the Roman Catholic Church. The responsibility of bishops to monitor Catholic institutions, including educational institutions, is noted. (MSE)

  11. "Of comics and men: A cultural history of American comic books," by Jean-Paul Gabilliet

    Directory of Open Access Journals (Sweden)

    Drew Morton

    2013-06-01

    Full Text Available Jean-Paul Gabilliet. Of comics and men: A cultural history of American comic books. Translated by Bart Beaty and Nick Nguyen. Jackson: University Press of Mississippi, 2010, hardcover, $55.00 (390p, ISBN 978-1604732672.

  12. Daamid poolpöördes : Paul Raua naisportreede taustast / Tiina Abel

    Index Scriptorium Estoniae

    Abel, Tiina

    2008-01-01

    Vendade Raudade loomingust sajandivahetusel ja nende erinevatest inspiratsiooniallikatest. Ka muutustest ühiskondlikus elus ja kultuuriteadvuses - pöördumine ühiskondlikult isiklikule ja psühholoogilisele, tegelikkuse ja indiviidi teadvuse ümbermõtestamine, ratsionaalse inimese asendumine tunnete ja instiktide inimesega - see ilmneb Paul Raua psühholoogilistes hingestatud naiseportreedes

  13. the lukan periplus of paul's third journey with a textual conundrum

    African Journals Online (AJOL)

    convenience of the few fee-paying passengers. to Jerusalem. Paul does ... starts to warn him of the danger ahead in Jerusalem, which probably occurred in Troas ... conduct business along the way at their nightly ports of call. 2.2 The genre of ...

  14. The angle of incidence of Paul Roux's catechism - a study on the ...

    African Journals Online (AJOL)

    With the Belijdenis of Paul Roux we have an indigenous document of early eighteenth century theological reflection among some French refugees of the first generations at the Cape. It provides us with useful opportunities to analyse the theology of an important part of the history of the Huguenots. In this study, attention is ...

  15. “Whatever gain I had ...”: Ethnicity and Paul's self-identification in ...

    African Journals Online (AJOL)

    This study is not an exercise in Vernon Robbin's groundbreaking socio-rhetorical criticism as put forth in his impressive The Tapestry of Early Christian Discourse and Exploring the Texture of Texts. It does have much in common with his “social and cultural texture”. It also touches “inner texture” in relation to Paul's implied ...

  16. The history and epidemiology of Cape St Paul wilt disease of ...

    African Journals Online (AJOL)

    The history of the spread of the Cape St. Paul Wilt (lethal yellowing) disease of coconut in Ghana is presented. Epidemiological studies showed that the disease starts slowly, then progresses (accelerate) rapidly before levelling off. In a farm, the disease first appears randomly on single trees, foci then develop around these ...

  17. Pope John Paul II's Address to Black Catholics: A Motive Analysis.

    Science.gov (United States)

    Costanza, Jean M.

    Pope John Paul's visit to the United States in 1987 provided many opportunities for the analysis of papal rhetoric. The Pope's address to black Catholics in America may be of particular interest to those focusing on the study of intercultural or interracial communication. This address did not garner as much media attention as did some of the…

  18. 77 FR 45965 - Determination of Attainment for the Paul Spur/Douglas PM10

    Science.gov (United States)

    2012-08-02

    ... Paul Spur/Douglas NA covers approximately 220 square miles along the border with Mexico within Cochise... Pirtleville, 2010 population 1,744, (U.S. Census). The 2010 population of Agua Prieta, Mexico, just across the border from Douglas, is 78,138 (Instituto Nacional de Estadistica y Geografia). To summarize our proposed...

  19. The neutron Electric Dipole Moment experiment at the Paul Scherrer Institute

    Directory of Open Access Journals (Sweden)

    Hélaine V.

    2014-06-01

    Full Text Available The neutron Electric Dipole Moment (nEDM is a probe for physics beyond the Standard Model. A report on the nEDM measurement performed at the Paul Scherrer Institute (Switzerland is given. A neutron spin analyzer designed to simultaneously detect both neutron spin states is presented.

  20. On social justice: Comparing Paul with Plato, Aristotle and the Stoics ...

    African Journals Online (AJOL)

    Although Crossan elsewhere demonstrates the deep roots of this concern in the Jewish tradition, he tends to downplay the importance of Greek contributions in this regard. The purpose of this essay will be to offer, in constant dialogue with. Crossan (and Reed), a more refined comparison of social justice in Paul on the one ...

  1. Paul Langerhans: a prilgrim "traveling" from functional histology to marine biology.

    Science.gov (United States)

    Raica, Marius; Cimpean, Anca Maria

    2017-06-01

    The nineteenth century was the time of a real revolution in science and medicine. A lot of seminal discoveries in medicine and biology were done in this time, and many of them were coincident with the introduction of the compound microscope by Hermann van Deijl and the standard histological technique by Paul Ehrlich. The main tissue types and individual cells were characterized and originally classified more than hundred years ago, although less attention was paid to their basic functions. This was mainly due to the modality of tissue specimen processing that allowed particularly detailed descriptive studies. Even so, we can notice some attempts to correlate the structure with the function. The German scientist Paul Langerhans, well-known for the discovery of Langerhans islets of the pancreas and Langerhans cells from the epidermis, tried to change the conventional fate of morphological studies introducing in his works functional hypothesis based on traditional microscopic observations even from the beginning of his scientific career. Paul Langerhans was a complex personality of the second half of the nineteenth century, not only in medicine, but also in other fields of biology. In the present review, presented is the life and research activity of Paul Langerhans, not only because of the importance of his discoveries, but also for perspectives that were opened by these findings in unexpected fields of medicine and biology.

  2. An Analysis of "City of Glass" by Paul Auster in Terms of Postmodernism

    Science.gov (United States)

    Odacioglu, Mehmet Cem; Loi, Chek Kim; Çoban, Faddime

    2017-01-01

    This study analyzes "City of Glass," a postmodernist detective novella (or anti-detective) of the "New York Trilogy" by Paul Auster in terms of postmodernist elements and techniques such as metafiction, parody, intertextuality, irony and like. In doing so, some information about Auster's life and the plot of the work are also…

  3. Effect of the synthetic cannabinoid HU-210 on quorum sensing and on the production of quorum sensing-mediated virulence factors by Vibrio harveyi

    OpenAIRE

    Soni, Divya; Smoum, Reem; Breuer, Aviva; Mechoulam, Raphael; Steinberg, Doron

    2015-01-01

    Background Bacterial populations communicate through the cell density-dependent mechanism of quorum sensing (QS). Vibrio harveyi, one of the best studied model organisms for QS, was used to explore effects of the synthetic cannabinoid HU-210 on QS and different QS-regulated physiological processes in bacteria. Results Analysis of QS-regulated bioluminescence in wild-type and mutant strains of V. harveyi revealed that HU-210 affects the autoinducer-2 (AI-2) pathway, one of three known QS casca...

  4. Changes in Cellular mRNA Stability, Splicing, and Polyadenylation through HuR Protein Sequestration by a Cytoplasmic RNA Virus

    Directory of Open Access Journals (Sweden)

    Michael D. Barnhart

    2013-11-01

    Full Text Available The impact of RNA viruses on the posttranscriptional regulation of cellular gene expression is unclear. Sindbis virus causes a dramatic relocalization of the cellular HuR protein from the nucleus to the cytoplasm in infected cells. This is to the result of the expression of large amounts of viral RNAs that contain high-affinity HuR binding sites in their 3′ UTRs effectively serving as a sponge for the HuR protein. Sequestration of HuR by Sindbis virus is associated with destabilization of cellular mRNAs that normally bind HuR and rely on it to regulate their expression. Furthermore, significant changes can be observed in nuclear alternative polyadenylation and splicing events on cellular pre-mRNAs as a result of sequestration of HuR protein by the 3′ UTR of transcripts of this cytoplasmic RNA virus. These studies suggest a molecular mechanism of virus-host interaction that probably has a significant impact on virus replication, cytopathology, and pathogenesis.

  5. Innate Immune Activation Can Trigger Experimental Spondyloarthritis in HLA-B27/Huβ2m Transgenic Rats

    Directory of Open Access Journals (Sweden)

    Melissa N. van Tok

    2017-08-01

    Full Text Available Spondyloarthritis (SpA does not display the typical features of auto-immune disease. Despite the strong association with MHC class I, CD8+ T cells are not required for disease induction in the HLA-B27/Huβ2m transgenic rats. We used Lewis HLA-B27/Huβ2m transgenic rats [21-3 × 283-2]F1, HLA-B7/Huβ2m transgenic rats [120-4 × 283-2]F1, and wild-type rats to test our hypothesis that SpA may be primarily driven by the innate immune response. In vitro, splenocytes were stimulated with heat-inactivated Mycobacterium tuberculosis and cytokine expression and production was measured. In vivo, male and female rats were immunized with 30, 60, or 90 µg of heat-inactivated M. tuberculosis and clinically monitored for spondylitis and arthritis development. After validation of the model, we tested whether prophylactic and therapeutic TNF targeting affected spondylitis and arthritis. In vitro stimulation with heat-inactivated M. tuberculosis strongly induced gene expression of pro-inflammatory cytokines such as TNF, IL-6, IL-1α, and IL-1β, in the HLA-B27 transgenic rats compared with controls. In vivo immunization induced an increased spondylitis and arthritis incidence and an accelerated and synchronized onset of spondylitis and arthritis in HLA-B27 transgenic males and females. Moreover, immunization overcame the protective effect of orchiectomy. Prophylactic TNF targeting resulted in delayed spondylitis and arthritis development and reduced arthritis severity, whereas therapeutic TNF blockade did not affect spondylitis and arthritis severity. Collectively, these data indicate that innate immune activation plays a role in the initiation of HLA-B27-associated disease and allowed to establish a useful in vivo model to study the cellular and molecular mechanisms of disease initiation and progression.

  6. La conversion de Paul, regards croisés Paul’s conversion. Cross perspectives

    Directory of Open Access Journals (Sweden)

    Elian Cuvillier

    2009-09-01

    Full Text Available Au plan historique, les traditions relatives à la conversion de Paul, chutant de son cheval sur le chemin de Damas, confrontent l’exégète à trois problèmes importants : y avait-il un cheval, cela se passait-il sur le chemin de Damas et était-ce bien une conversion ? Entendues avec l’humour et la distance critique nécessaires, ces trois questions constituent les trois chapitres de cet article. Le premier « Y avait-il un cheval ? » s’intéresse à l’histoire de la réception de l’épisode de la conversion de Paul, en particulier dans la peinture et la littérature. Le second « Cela se passait-il sur le chemin de Damas ? » est consacrée au récit que l’auteur du livre des Actes propose de la conversion de Paul, récit qui constitue, bien souvent, la porte d’entrée exclusive pour aborder le thème. Le troisième « Etait-ce bien une conversion ? » analyse les témoignages de l’apôtre lui-même à travers deux passages clés de ses épîtres authentiques.Historically speaking, the traditions concerning the conversion of Paul, falling from his horse on the road to Damascus, confront the exegete with three important problems : was there a horse, did it happen on the road to Damacus and was it really a conversion ? These three questions, considered with humor and critical distance, constitute the three sections of this article. The first part « Was there a horse ? » considers the history of the reception of the episode of the conversion of Paul, particularly in art and literature. The second one « Did it happen on the road to Damascus ? » is devoted to the story of the conversion of Paul proposed by the author of the book of Acts, which is very often the exclusive entrance to the discussion of this theme. The third section « Was it really a conversion ? » analyzes the account given by the apostle himself in two key passages of his authentic epistles.

  7. HuR and podoplanin expression is associated with a high risk of malignant transformation in patients with oral preneoplastic lesions.

    Science.gov (United States)

    Habiba, Umma; Kitamura, Tetsuya; Yanagawa-Matsuda, Aya; Higashino, Fumihiro; Hida, Kyoko; Totsuka, Yasunori; Shindoh, Masanobu

    2016-11-01

    The risk of malignant transformation in oral preneoplastic lesions (OPLs) is challenging to assess. The objective of the present study was to determine the expression of ELAV like RNA binding protein 1 (HuR) and podoplanin in OPLs, and to evaluate the use of each protein as biomarkers for the risk assessment of malignant transformations. Immunohistochemistry for HuR and podoplanin was performed on the tissues of 51 patients with OPL, including cases of low grade dysplasia (LGD) and high grade dysplasia (HGD). The association between the protein expression patterns and clinicopathological parameters, including oral cancer free survival (OCFS) time, was analyzed during the follow-up period. HuR and podoplanin expression was observed in 28 (55%) and 36 (71%) of 51 patients, respectively. Kaplan-Meier analysis showed that the expression of HuR and podoplanin was associated with the risk of progression to oral cancer (P<0.05). Multivariate analysis revealed that HuR and podoplanin expression was associated with a 2.93-fold (95% confidence interval (CI), 0.98-10.34; P=0.055) and 2.06-fold (95% CI, 0.55-8.01; P=0.283) increase in risk of malignant transformation, respectively. The risk of OPL malignant transformation was considerably increased with the coexpression of HuR and podoplanin compared with the histological grading (95% CI, 1.64-23.59; P=0.005). The results of the present study demonstrated that the expression of HuR and podoplanin associates with malignant transformation and suggests that the proteins may be used as biomarkers to identify OPL patients with an increased risk of cancer development.

  8. HuB (elavl2 mRNA is restricted to the germ cells by post-transcriptional mechanisms including stabilisation of the message by DAZL.

    Directory of Open Access Journals (Sweden)

    Sophie E Wiszniak

    Full Text Available The ability of germ cells to carry out a gene regulatory program distinct from the surrounding somatic tissue, and their capacity to specify an entire new organism has made them a focus of many studies that seek to understand how specific regulatory mechanisms, particularly post-transcriptional mechanisms, contribute to cell fate. In zebrafish, germ cells are specified through the inheritance of cytoplasmic determinants, termed the germ plasm, which contains a number of maternal mRNAs and proteins. Investigation of several of these messages has revealed that the restricted localisation of these mRNAs to the germ plasm and subsequent germ cells is due to cis-acting sequence elements present in their 3'UTRs. Here we show that a member of the Hu family of RNA-binding proteins, HuB, is maternally provided in the zebrafish embryo and exhibits germ cell specific expression during embryogenesis. Restriction of HuB mRNA to the germ cells is dependent on a number of sequence elements in its 3'UTR, which act to degrade the mRNA in the soma and stabilise it in the germ cells. In addition, we show that the germ cell specific RNA-binding protein DAZL is able to promote HuB mRNA stability and translation in germ cells, and further demonstrate that these activities require a 30 nucleotide element in the 3'UTR. Our study suggests that DAZL specifically binds the HuB 3'UTR and protects the message from degradation and/or enhances HuB translation, leading to the germ cell specific expression of HuB protein.

  9. Treatment of depression with Chai Hu Shu Gan San: a systematic review and meta-analysis of 42 randomized controlled trials.

    Science.gov (United States)

    Sun, Yan; Xu, Xia; Zhang, Jinping; Chen, Yuanyuan

    2018-02-17

    Depression is a common mental disorder. Chai Hu Shu Gan San, a traditional Chinese medicine, is used to treat depression empirically. We present a systematic review and meta-analysis of the therapeutic efficacy and safety of Chai Hu Shu Gan San in treating depression. Several databases, including PubMed, China National Knowledge Internet, Wanfang, Chongqing VIP, and the Cochrane library, were systematically searched from their date of foundation to January 1, 2017. In this review, wehave included randomized control trials that compared Chai Hu Shu Gan San (or its combination with a regular Western medicine) with a regular Western medicine alone for the treatment of depression. Two investigators independently extracted and analyzed the data using RevMan 5.2.0 software. Mean difference (with a 95% confidence interval) was used as efficacy indices for outcomes. We included 42 studies involving 3234 patients with depression in 15 different types of diseases. Meta analyses showed better effect of Chai Hu Shu Gan San than fluoxetine for pure depression (MD = - 1.59, from - 2.82 to - 0.37, 4 trials, I 2  = 26%), for post-stroke depression (MD = - 4.20, from - 6.20 to - 2.19, 7 trials, I 2  = 96%), and for postpartum depression (MD = - 4.10, from - 7.48 to - 0.72 7 trials, I 2  = 86%). None of the articles reported severe adverse events of oral administration of Chai Hu Shu Gan San. Furthermore, any adverse effects of using Chai Hu Shu Gan San alone were fewer than those of regular Western medicines. This review found that Chai Hu Shu Gan San has some advantages in treating depression, especially post-stroke depression and post-partum depression. A meticulously designed and conducted randomized control trial is needed for further evaluation.

  10. One of the Two Genes Encoding Nucleoid-Associated HU Proteins in Streptomyces coelicolor Is Developmentally Regulated and Specifically Involved in Spore Maturation▿ †

    Science.gov (United States)

    Salerno, Paola; Larsson, Jessica; Bucca, Giselda; Laing, Emma; Smith, Colin P.; Flärdh, Klas

    2009-01-01

    Streptomyces genomes encode two homologs of the nucleoid-associated HU proteins. One of them, here designated HupA, is of a conventional type similar to E. coli HUα and HUβ, while the other, HupS, is a two-domain protein. In addition to the N-terminal part that is similar to that of HU proteins, it has a C-terminal domain that is similar to the alanine- and lysine-rich C termini of eukaryotic linker histones. Such two-domain HU proteins are found only among Actinobacteria. In this phylum some organisms have only a single HU protein of the type with a C-terminal histone H1-like domain (e.g., Hlp in Mycobacterium smegmatis), while others have only a single conventional HU. Yet others, including the streptomycetes, produce both types of HU proteins. We show here that the two HU genes in Streptomyces coelicolor are differentially regulated and that hupS is specifically expressed during sporulation, while hupA is expressed in vegetative hyphae. The developmental upregulation of hupS occurred in sporogenic aerial hyphal compartments and was dependent on the developmental regulators whiA, whiG, and whiI. HupS was found to be nucleoid associated in spores, and a hupS deletion mutant had an average nucleoid size in spores larger than that in the parent strain. The mutant spores were also defective in heat resistance and spore pigmentation, although they possessed apparently normal spore walls and displayed no increased sensitivity to detergents. Overall, the results show that HupS is specifically involved in sporulation and may affect nucleoid architecture and protection in spores of S. coelicolor. PMID:19717607

  11. pp32 (ANP32A expression inhibits pancreatic cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNAs.

    Directory of Open Access Journals (Sweden)

    Timothy K Williams

    Full Text Available The expression of protein phosphatase 32 (PP32, ANP32A is low in poorly differentiated pancreatic cancers and is linked to the levels of HuR (ELAV1, a predictive marker for gemcitabine response. In pancreatic cancer cells, exogenous overexpression of pp32 inhibited cell growth, supporting its long-recognized role as a tumor suppressor in pancreatic cancer. In chemotherapeutic sensitivity screening assays, cells overexpressing pp32 were selectively resistant to the nucleoside analogs gemcitabine and cytarabine (ARA-C, but were sensitized to 5-fluorouracil; conversely, silencing pp32 in pancreatic cancer cells enhanced gemcitabine sensitivity. The cytoplasmic levels of pp32 increased after cancer cells are treated with certain stressors, including gemcitabine. pp32 overexpression reduced the association of HuR with the mRNA encoding the gemcitabine-metabolizing enzyme deoxycytidine kinase (dCK, causing a significant reduction in dCK protein levels. Similarly, ectopic pp32 expression caused a reduction in HuR binding of mRNAs encoding tumor-promoting proteins (e.g., VEGF and HuR, while silencing pp32 dramatically enhanced the binding of these mRNA targets. Low pp32 nuclear expression correlated with high-grade tumors and the presence of lymph node metastasis, as compared to patients' tumors with high nuclear pp32 expression. Although pp32 expression levels did not enhance the predictive power of cytoplasmic HuR status, nuclear pp32 levels and cytoplasmic HuR levels associated significantly in patient samples. Thus, we provide novel evidence that the tumor suppressor function of pp32 can be attributed to its ability to disrupt HuR binding to target mRNAs encoding key proteins for cancer cell survival and drug efficacy.

  12. Efficacy of the Frame and Hu mathematical model for the quantitative analysis of agents influencing growth of chick embryo fibroblasts

    International Nuclear Information System (INIS)

    Korohoda, K.; Czyz, J.

    1994-01-01

    The experiments on the effect of various sera and substratum surface area upon growth of chick embryo fibroblasts-like in secondary cultures are described and discussed on the grounds of a mathematical model for growth of anchorage-dependent cells proposed by Frame and Hu. The model and presented results demonstrate the mutual independence of the effects of agent influencing of rate of cell proliferation (i.e. accelerating or retarding growth) and the agents that modify the limitation of cell proliferation (i.e. maximum cell density at confluence). The model proposed by Frame and Hu due to its relative simplicity offers and easy mode of description and quantitative evaluation of experiments concerning cell growth regulation. It is shown that various sera added at constant concentration significantly modify the rate of cell proliferation with little effect upon the maximum cell density attainable. The cells grew much more slowly in the presence of calf serum than in the presence of chick serum and the addition of iron and zinc complexes to calf serum significantly accelerated cell growth. An increase in the substratum surface area by the addition of glass wool to culture vessels significantly increased cell density per constant volume of medium even when retardation of growth was observed. The results presented point to the need of direct cell counting for estimation of cell growth curves and discussion of effects of agents influencing parameters characterizing cell proliferation. (author). 34 refs, 5 figs, 2 tabs

  13. Sympathetic cooling and crystallization of ions in a linear Paul trap

    International Nuclear Information System (INIS)

    Drewsen, M.; Bowe, P.; Hornekaer, L.; Brodersen, C.; Schiffer, J.P.; Hangst, J.S.; Schiffer, J.P.

    1999-01-01

    Coulomb crystals, containing up to a few hundred ions of which more than 50% were cooled sympathetically by the Coulomb interaction with laser cooled Mg + ions, have been produced in a linear Paul trap. By controlling the balance of the radiation pressure from the two cooling lasers, the Coulomb crystals could be segregated according to ion species. Previous studies of ion crystals and molecular dynamics simulations suggest that the temperature may be around 10 mK or lower. The obtained results indicate that a wide range of atomic and molecular ions, which due to their internal structures are not amenable to direct laser cooling, can be effectively cooled and localized (crystallized) in linear Paul traps. For high resolution spectroscopy of such ions this may turn out to be very useful. copyright 1999 American Institute of Physics

  14. Development of Laser-Induced Fluorescence Diagnostic for the Paul Trap Simulator Experiment

    CERN Document Server

    Chung, Moses; Efthimion, Philip; Gilson, Erik P; Majeski, Richard; Startsev, Edward

    2005-01-01

    The Paul Trap Simulator Experiment (PTSX) is a cylindrical Paul trap whose purpose is to simulate the nonlinear dynamics of intense charged particle beam propagation in alternating-gradient magnetic transport systems. For the in-situ measurement of the transverse ion density profile in the PTSX device, which is essential for the study of beam mismatch and halo particle production, a laser-induced fluorescence diagnostic system is being developed. Instead of cesium, which has been used in the initial phase of the PTSX experiment, barium has been selected as the preferred ion for the laser-induced fluorescence diagnostic. The installation of the barium ion source and the characterization of the tunable dye laser system are discussed. The design of the collection optics with an intensified CCD camera system is also discussed. Finally, initial test results using the laser-induced fluorescence diagnostic will be presented.

  15. Simulating the Long-Distance Propagation of Intense Beams in the Paul Trap Simulator Experiment

    CERN Document Server

    Gilson, Erik P; Davidson, Ronald C; Efthimion, Philip; Majeski, Richard; Startsev, Edward

    2005-01-01

    The Paul Trap Simulator Experiment (PTSX) makes use of a compact Paul trap configuration with quadrupolar oscillating wall voltages to simulate the propagation of intense charged particle beams over distances of many kilometers through magnetic alternating-gradient transport systems. The simulation is possible because of the similarity between the transverse dynamics of particles in the two systems. One-component pure cesium ion plasmas have been trapped that correspond to normalized intensity parameters s < 0.8, where s is the ratio of the square of the plasma frequency to twice the square of the average transverse focusing frequency. The PTSX device confines the plasma for hundreds of milliseconds, which is equivalent to beam propagation over tens of kilometers. Results are presented for experiments in which the amplitude of the oscillating confining voltage waveform has been modified as a function of time. A comparison is made between abrupt changes in amplitude and adiabatic changes in amplitude. T...

  16. Laser-Induced Fluorescence diagnostic of barium ion plasmas in the Paul Trap Simulator Experiment

    International Nuclear Information System (INIS)

    Chung, Moses; Gilson, Erik P.; Davidson, Ronald C.; Efthimion, Philip C.; Majeski, Richard; Startsev, Edward A.

    2005-01-01

    The Paul Trap Simulator Experiment (PTSX) is a cylindrical Paul trap whose purpose is to simulate the nonlinear dynamics of intense charged particle beam propagation in alternating-gradient magnetic transport systems. To investigate the ion plasma microstate in PTSX, including the ion density profile and the ion velocity distribution function, a laser-induced fluorescence diagnostic system is being developed as a nondestructive diagnostic. Instead of cesium, which has been used in the initial phase of the PTSX experiment, barium has been selected as the preferred ion for the laser-induced fluorescence diagnostic. A feasibility study of the laser-induced fluorescence diagnostic using barium ions is presented with the characterization of a tunable dye laser. The installation of the barium ion source and the development of the laser-induced fluorescence diagnostic system are also discussed

  17. Recent advances in the physics of collective excitations in the Paul trap simulator experiment

    International Nuclear Information System (INIS)

    Gilson, E.P.; Chung, M.; Davidson, R.C.; Dorf, M.; Efthimion, P.C.; Godbehere, A.B.; Majeski, R.

    2009-01-01

    The Paul trap simulator experiment (PTSX) is a compact laboratory linear Paul trap that simulates the transverse dynamics of a long charged-particle bunch propagating through a magnetic alternating-gradient (AG) transport system. The transverse dynamics of particles in the AG system in the beam's frame-of-reference and those of particles in PTSX are described by the same sets of equations, including all nonlinear space-charge effects. Initial experimental results are presented in which the collective transverse symmetric mode (m=0) and quadrupole mode (m=2) have been observed in pure-barium-ion plasmas in PTSX, with a depressed-tune ν/ν 0 ∼0.9, with the intent of identifying collective modes whose signature will serve as a robust diagnostic for key properties of the beam, such as line density and transverse emittance. The results of particle-in-cell simulations performed with the WARP code are compared to the experimental data.

  18. The Common Sense Personalism of St. John Paul II (Karol Wojtyła

    Directory of Open Access Journals (Sweden)

    Pawel Tarasiewicz

    2014-12-01

    Full Text Available The article aims at showing that the philosophical personalism of Pope John Paul II (Karol Wojtyla stems from the common sense approach to reality. First, it presents Karol Wojtyla as a framer of the Lublin Philosophical School, to which he was affiliated for 24 years before being elected Pope John Paul II; it shows Wojtyla’s role in establishing this original philosophical School by his contribution to its endorsement of Thomism, its way of doing philosophy, and its classically understood personalism. Secondly, it identifies a purpose of Wojtyla’s use of the phenomenological method in his personalism and reconstructs Wojtyla’s possible answer to the question whether there is a link between moral sense and common sense in human experience.

  19. 20 old and rare books from the library of Paul Gore

    Directory of Open Access Journals (Sweden)

    Liviu Papuc

    2014-12-01

    Full Text Available As is well known, most of the large library of Paul Gore, nearly 5,000 volumes, as evidenced by preserved inventory list, is currently kept in the “M. Eminescu” Central University Library in Iaşi. Based on dozens of specimens found in the storages and on the notes made by Paul Gore in the inventory-catalog, the paper presents their bibliographic description. It is made in the continuation of a communication that is to be printed in the Magazine of the Museum of the “Al.I. Cuza” University of Iaşi and in order to complete a full catalog of the library of the great scientist, the work on which was begun with great success by other researchers in the field.

  20. The LPCTrap facility: A novel transparent Paul trap for high-precision experiments

    International Nuclear Information System (INIS)

    Rodriguez, D.; Mery, A.; Ban, G.; Bregeault, J.; Darius, G.; Durand, D.; Flechard, X.; Herbane, M.; Labalme, M.; Lienard, E.; Mauger, F.; Merrer, Y.; Naviliat-Cuncic, O.; Thomas, J.C.; Vandamme, C.

    2006-01-01

    A trap system has been built to perform high-precision β-decay experiments. The system is coupled to the low-energy beam line of the SPIRAL source at GANIL. The continuous ion beam from SPIRAL with energies between 10 and 20keV is slowed down by means of a buffer-gas-filled RFQ trap and ejected thereafter as short ion bunches into a novel transparent Paul trap. Two pulsed cavities located downstream from the RFQ reduce the energy of the ion bunch down to about a hundred eV for an efficient capture in the Paul trap. We describe here the complete system along with the first results obtained with stable He+4, Cl+35 and Ar+36,40 ions from the SPIRAL ECR source. An overall efficiency of 8.7(8)x10 -4 is achieved for 4 He + ions under specific conditions

  1. STUDI KOMPARASI SAMINISME DENGAN JEAN PAUL SARTRE TENTANG KEBEBASAN (Tinjauan Filsafat Sosial

    Directory of Open Access Journals (Sweden)

    Restu Trisnova

    2016-09-01

    Full Text Available The comparative study between Saminism concept and Jean Paul Sartre thought of freedom are: 1 Human freedom, according to Sartre, is an absolute freedom. No other rules which are able to determine human either God or other people; 2 The Saminism concept of freedom is an individual freedom. It means every individual as a subject is able to decide their own choice. Every individual as a subject is independent without any outside order; 3 Saminism freedom conveys individual responsibility. It means every person’s freedom has individual responsibility. Every doer subject can decide everything based on their interest. Therefore, the freedom and responsibility in Saminism actualizes the Jean Paul Sartre thought of freedom.

  2. The Doctrine of Incommensurability in Paul Feyerabend. An Objection Against a Particular Conception of Scientific Rationality

    Directory of Open Access Journals (Sweden)

    Teresa Gargiulo

    2017-08-01

    Full Text Available Incommensurability has caused many controversies and debates. In these debates seems to be unanimous the interpretation of that doctrine as an objection to objectivity, realism and scientific progress. Now this is a narrow hermeneutical framework for understanding the intention of Paul Feyerabend when formulating his doctrine of incommensurability. Because he was never intended to challenge such notions in themselves but only to show how vain turns out to be the neo-positivism and Popperian rationalism´s attempt to define them. In a positive sense we argue that incommensurability, according to Paul Feyerabend, prevents or impedes when we comes to define those notions return to dialectical of logical positivism or critical rationalism. Our intention in this paper is to present his thesis of incommensurability as a challenge to a particular way of conceiving scientific rationality and its consequent notions of objectivity, progress and scientific realism.

  3. Performing Protest in Cross-Cultural Spaces: Paul Robeson and Othello

    Directory of Open Access Journals (Sweden)

    Sawyer Robert

    2017-09-01

    Full Text Available When the famous African-American actor and singer Paul Robeson played the lead in Shakespeare’s Othello in London in 1930, tickets were in high demand during the production’s first week. The critical response, however, was less positive, although the reviews unanimously praised his bass-baritone delivery. When Robeson again played Othello on Broadway thirteen years later, critics praised not only his voice but also his acting, the drama running for 296 performances. My argument concerning Robeson uses elements first noted by Henri Lefebvre in his seminal work, The Production of Space, while I also draw on Paul Connerton’s work on commemorative practices. Using spatial and memorial theories as a backdrop for examining his two portrayals, I suggest that Robeson’s nascent geopolitical awareness following the 1930 production, combined with his already celebrated musical voice, allowed him to perform the role more dramatically in 1943.

  4. The Paul Scherrer Institute, a multidisciplinary organization opened to the world

    International Nuclear Information System (INIS)

    Mayer, N.

    2008-01-01

    At the end of the second world war, the Swiss Federal Military department created a commission for the study of nuclear energy under the presidency of Paul Scherrer. This famous Swiss physicist was particularly interested in this new domain of physics and will be few years later one of the main actor of the creation of CERN, a European organization for nuclear research. Some financial problems and a nuclear accident in 1969 have blown away the dreams of a nuclear reactor entirely made in Switzerland. The Paul Scherrer Institute was born in this context in 1988 near Zurich. Twenty years later it employs about 1300 people with an operating budget of about 175 million euros financed at 85% by the Swiss confederation. This article presents the different domains of research of the institute, its infrastructures (X-ray, neutrons and muons probes), its technology transfer actions and the cooperations with France. (J.S.)

  5. Metapsychology or metapsychologies? Some comments on Paul Denis's paper 'The drive revisited: mastery and satisfaction'.

    Science.gov (United States)

    Sapisochin, Gabriel

    2016-06-01

    In this commentary on Paul Denis's paper 'The drive revisited: mastery and satisfaction', the author defends the idea of a plurality of metapsychologies that must be contrasted with and distinguished from each other while avoiding incompatible translations between models. In this connection he presents various theoretical approaches to aggression and the death drive, and demonstrates the differences between the drive model and the model underlying the theory of internalized object relations. The author holds that the concept of the internal object differs from Freud's notion of the representation (Vorstellung). He also considers that the imago as defined by Paul Denis in fact corresponds to the concept of the internal object. Lastly, he addresses the complex issue of listening to archaic forms of psychic functioning and their non-discursive presentation within the analytic process, which affects the transference-countertransference link. Copyright © 2016 Institute of Psychoanalysis.

  6. Stability of Coulomb crystals in a linear Paul trap with storage-ring-like confinement

    DEFF Research Database (Denmark)

    Kjærgaard, Niels; Mølhave, Kristian; Drewsen, Michael

    2002-01-01

    We report experiments on the stability of ion Coulomb crystals in a linear Paul trap with storage-ring-like confinement. The transverse dynamics of charged particles in a trap of this type is analogous to that of a fast beam traveling through a channel with periodic, magnetic alternating gradient...... confinement. The experimentally observed stability conditions for stationary crystals comply remarkably well with current theory of crystalline plasmas and beams.......We report experiments on the stability of ion Coulomb crystals in a linear Paul trap with storage-ring-like confinement. The transverse dynamics of charged particles in a trap of this type is analogous to that of a fast beam traveling through a channel with periodic, magnetic alternating gradient...

  7. Mr Paul: Masculinity and Paul’s self-presentation (1 Cor 11–13

    Directory of Open Access Journals (Sweden)

    Jeremy Punt

    2016-10-01

    Full Text Available Notwithstanding all the corporeal and gendered language in the Pauline letters, the apostle’s bodiliness and masculinity so far has received little attention. In the 1st-century context masculinity reigned by default and provides the contemporary context for teasing out the corporeal and gendered overtones in the Pauline letters, especially in Paul’s self-presentation. Recent and intersecting masculinity studies, body theology and queer theory provide useful tools for engaging Paul as man and his bodily-focussed, gendered approach in his letters. A focus on both Paul as embodied man and his corporeal, gendered approach enable alternative readings of his letters’ concern with corporeality and the related relationships between bodies, power and life in the communities he addressed.

  8. Measurements of β - ν angular correlations using a transparent Paul trap

    International Nuclear Information System (INIS)

    Ban, G.; Delahaye, P.; Le Brun, Ch.; Lienard, E.; Mauger, F.; Naviliat-Cuncic, O.; Szerypo, J.; Tamain, B.

    1999-06-01

    The potentiality to search for physics beyond the Standard Model by means of precision measurements of β - ν angular correlations in nuclear β-decay is discussed. The possibility to reveal unexpected time reversal invariant tensor type contributions is investigated and the pure Gamow-Teller decay of 6 He is considered as a possible candidate. A new experimental method is proposed which is based on the use of a transparent Paul trap surrounded by detectors to directly record β-ion coincidences in an event-by-event mode. The experiment requires intense beams of radioactive nuclei like those which will become available at the Low Energy Facility near SPIRAL at GANIL. Such beams should preferably be efficiently cooled and bunched prior to their injection into the Paul trap. Estimates of the transmission figure required for the cooling and bunching system and of the measuring time to achieve a first step are presented. (author)

  9. HuR cytoplasmic expression is associated with increased cyclin A expression and poor outcome with upper urinary tract urothelial carcinoma

    International Nuclear Information System (INIS)

    Liang, Peir-In; Shiue, Yow-Ling; Huang, Hsuan-Ying; Hsu, Han-Ping; Chen, Li-Tzon; Lin, Ching-Yih; Tai, Chein; Lin, Chun-Mao; Li, Chien-Feng; Li, Wei-Ming; Wang, Yu-Hui; Wu, Ting-Feng; Wu, Wen-Ren; Liao, Alex C; Shen, Kun-Hung; Wei, Yu-Ching; Hsing, Chung-Hsi

    2012-01-01

    HuR is an RNA-binding protein that post-transcriptionally modulates the expressions of various target genes implicated in carcinogenesis, such as CCNA2 encoding cyclin A. No prior study attempted to evaluate the significance of HuR expression in a large cohort with upper urinary tract urothelial carcinomas (UTUCs). In total, 340 cases of primary localized UTUC without previous or concordant bladder carcinoma were selected. All of these patients received ureterectomy or radical nephroureterectomy with curative intents. Pathological slides were reviewed, and clinical findings were collected. Immunostaining for HuR and cyclin A was performed and evaluated by using H-score. The results of cytoplasmic HuR and nuclear cyclin A expressions were correlated with disease-specific survival (DSS), metastasis-free survival (MeFS), urinary bladder recurrence-free survival (UBRFS), and various clinicopathological factors. HuR cytoplasmic expression was significantly related to the pT status, lymph node metastasis, a higher histological grade, the pattern of invasion, vascular and perineurial invasion, and cyclin A expression (p = 0.005). Importantly, HuR cytoplasmic expression was strongly associated with a worse DSS (p < 0.0001), MeFS (p < 0.0001), and UBRFS (p = 0.0370) in the univariate analysis, and the first two results remained independently predictive of adverse outcomes (p = 0.038, relative risk [RR] = 1.996 for DSS; p = 0.027, RR = 1.880 for MeFS). Cyclin A nuclear expression was associated with a poor DSS (p = 0.0035) and MeFS (p = 0.0015) in the univariate analysis but was not prognosticatory in the multivariate analyses. High-risk patients (pT3 or pT4 with/without nodal metastasis) with high HuR cytoplasmic expression had better DSS if adjuvant chemotherapy was performed (p = 0.015). HuR cytoplasmic expression was correlated with adverse phenotypes and cyclin A overexpression and also independently predictive of worse DSS and MeFS, suggesting its roles in

  10. The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer

    Directory of Open Access Journals (Sweden)

    Chen Jing

    2010-04-01

    Full Text Available Abstract Background The discordance between steady-state levels of mRNAs and protein has been attributed to posttranscriptional control mechanisms affecting mRNA stability and translation. Traditional methods of genome wide microarray analysis, profiling steady-state levels of mRNA, may miss important mRNA targets owing to significant posttranscriptional gene regulation by RNA binding proteins (RBPs. Methods The ribonomic approach, utilizing RNA immunoprecipitation hybridized to microarray (RIP-Chip, provides global identification of putative endogenous mRNA targets of different RBPs. HuR is an RBP that binds to the AU-rich elements (ARE of labile mRNAs, such as proto-oncogenes, facilitating their translation into protein. HuR has been shown to play a role in cancer progression and elevated levels of cytoplasmic HuR directly correlate with increased invasiveness and poor prognosis for many cancers, including those of the breast. HuR has been described to control genes in several of the acquired capabilities of cancer and has been hypothesized to be a tumor-maintenance gene, allowing for cancers to proliferate once they are established. Results We used HuR RIP-Chip as a comprehensive and systematic method to survey breast cancer target genes in both MCF-7 (estrogen receptor positive, ER+ and MDA-MB-231 (estrogen receptor negative, ER- breast cancer cell lines. We identified unique subsets of HuR-associated mRNAs found individually or in both cell types. Two novel HuR targets, CD9 and CALM2 mRNAs, were identified and validated by quantitative RT-PCR and biotin pull-down analysis. Conclusion This is the first report of a side-by-side genome-wide comparison of HuR-associated targets in wild type ER+ and ER- breast cancer. We found distinct, differentially expressed subsets of cancer related genes in ER+ and ER- breast cancer cell lines, and noted that the differential regulation of two cancer-related genes by HuR was contingent upon the cellular

  11. Cambridge Illustrated History of Archaeology, edited by Paul G. Bahn, Cambridge University Press, New York, 1996

    OpenAIRE

    Givens, Douglas R.

    1997-01-01

    The Cambridge Illustrated History of Archaeology is another in a series of volumes devoted to the history of archaeology that have appeared in recent time. Paul Bahn, the editor of the volume, has broken down his coverage of the history of worldwide archaeology into the following arrangement 'The Archaeology of Archaeology", "Old Worlds and New, 1500-1760", "Antiquarians and Explorers, 1760-1820", "Science and Romantic...

  12. The Lukan periplus of Paul's third journey with a textual conundrum ...

    African Journals Online (AJOL)

    A lexical discussion of ἄντικρυς Χίου is presented, and possible translations are reviewed. The article presents a new hypothesis that the Ionian city of Erythrae was the place of the ship's landing. It closes with a brief history of Erythrae's significance in the Greco-Roman world and why a stop there by Paul's coasting vessel ...

  13. La norma e la libertà: la sfida etica di Paul Ricoeur

    OpenAIRE

    Furia, Paolo

    2015-01-01

    This paper deals with the relation between freedom and norm in the practical philosophy of Paul Ricoeur, taking into account especially the “Little Ethics” that covers Studies VII, VIII, IX of Oneself as Another. Although Ricoeur states the priority of ethics over moral, playing the quest for good and happiness off against deontological morality of duty, it soon appears clear that the norm is necessarily implied by the development of ethics itself. No actual freedom can exist without norm; bu...

  14. Measurement of Secular Motion Frequency in Miniature Paul Trap to Ascertain the Stability Parameters

    International Nuclear Information System (INIS)

    Bin, Guo; Hua, Guan; Qu, Liu; Yao, Huang; Xue-Ren, Huang; Ke-Lin, Gao

    2010-01-01

    40 Ca + ions are trapped and laser cooled in a miniature Paul trap. The secular motion was observed by the radio-frequency resonance of the ion cloud and Zeeman profile sidebands of a single ion experimentally. The trap stability parameters a and q are determined with an uncertainty under 1 % by the secular motion frequency measurement. The trap efficiency is 0.75. A practicable suggestion is given for the benefits of a new trap design. (atomic and molecular physics)

  15. Séminaire de probabilités XXXIX in memoriam Paul-André Meyer

    CERN Document Server

    Yor, Marc

    2006-01-01

    The 39th volume of Séminaire de Probabilités is a tribute to the memory of Paul André Meyer. His life and achievements are recalled; homages are rendered by his friends and colleagues. This volume also contains mathematical contributions to classical and quantum stochastic calculus, the theory of processes, martingales and their applications to mathematical finance, Brownian motion. They provide an overview on the current trends of stochastic calculus.

  16. Transformation in love in Paul's letter to the Galatians | de Villiers ...

    African Journals Online (AJOL)

    Paul's Letter to the Galatians is known as a bitter defence of his “true” gospel of faith against opponents who wish to impose their “false” gospel of works on the faith community. This focus on the faith-works controversy has not been conducive to attempts to read it in terms of the notion of love. This article seeks to reconsider ...

  17. The command to love the neighbour in Paul and the Synoptics

    Directory of Open Access Journals (Sweden)

    Heinz A. Hiestermann

    2016-03-01

    Full Text Available When sayings of Jesus are compared between the Pauline letters and the Synoptic Gospels in an attempt to locate parallels, Galatians 5:14 and Romans 13:8�10 have frequently been put forward as possible parallels to the Synoptic renditions of the great commandment of Mark 12:28�34 (Mt 22:34�40; Lk 10:25�28. These Pauline and Synoptic texts all contain the command to love the neighbour, but the Synoptic texts have added the command to love God to the command to love the neighbour. Paul never quoted the great commandment. Consequently, a relationship between the verses is normally rejected. However, not all possibilities have been explored. In the search for parallels between Pauline and Synoptic Jesus traditions it has been overlooked that Paul and Matthew render the command to love the neighbour more than once. Matthew delivers the command to love the neighbour three times. Only once he has connected it to the command to love God. Matthew renders the single command to love the neighbour twice, resembling the Pauline use of the command. Using the criteria for validating parallels between Pauline and Synoptic Jesus traditions, including verbal agreement and the unique use of the command to love the neighbour by Paul and Matthew, it is argued that a connection between Romans 13:9 and Matthew 19:18�19 is likely.Intradisciplinary and/or interdisciplinary implications: The research explores the use of Leviticus 19:18b by the New Testament authors. It is argued that the command to love the neighbour was given high prominence in the early church, as it was used by the Synoptic authors and by Paul to summarise Jesus� ethical teachings.

  18. What Happened to Paul? Manifestation of Abnormal Pain Response for Individuals With Autism Spectrum Disorder.

    Science.gov (United States)

    Goldschmidt, Janice

    2017-07-01

    During the progression of a pilot nutrition intervention designed to teach cooking skills to young adults with autism spectrum disorder (ASD), one participant-Paul-fell in the parking lot. Prior to the accident, Paul had been making significant gains in the program and had communicated in a number of ways his enthusiasm. After his accident, which resulted in broken and dislocated bones in his ankle, his demeanor was dramatically altered, program gains were lost, and staff noted the appearance of many new challenging behaviors. This article analyzes Paul's behavior in reference to the pain response in autism. For some time, it was believed that many individuals with ASD did not experience pain based on anecdotal reports of how individuals responded to injury with seeming indifference. This view has given way of late to a more nuanced understanding of how atypical sensory processing and stimulus over-selectivity spill over into pain pathways and pain amplification mechanisms. The consequence is not a reduction in pain sensation, but a different expression of pain, determined by that individual's particular communicative, cognitive, or physiological challenges. From this perspective, many of the disruptive and harmful behaviors that emerged after Paul's accident can be seen as a delayed response to the incident. This article concludes by arguing that professionals across all domains of health care need to begin to see behavior as communicative for those with ASD. This is particularly true of changes in behavior, which can be significant indicators of health care problems rather than something to be dismissed as another manifestation of the condition.

  19. Mathematical statistics and limit theorems Festschrift in honour of Paul Deheuvels

    CERN Document Server

    Mason, David; Pfeifer, Dietmar; Steinebach, Josef

    2015-01-01

    This Festschrift in honour of Paul Deheuvels’ 65th birthday compiles recent research results in the area between mathematical statistics and probability theory with a special emphasis on limit theorems. The book brings together contributions from invited international experts to provide an up-to-date survey of the field. Written in textbook style, this collection of original material addresses researchers, PhD and advanced Master students with a solid grasp of mathematical statistics and probability theory.  

  20. Assimilating to Power in Two Different World-Systems: An Analysis of Paul and Herzl

    Directory of Open Access Journals (Sweden)

    Khaldoun Samman

    2015-08-01

    Full Text Available This essay concerns two Jewish men from different historical formations: the Apostle Paul, a Jew living in the Roman Empire in the first century and one of the founding figures of Christianity, and Theodor Herzl, a Jew living in late-nineteenth-century Austria and the founding father of Zionism, a Jewish nationalist movement. My central argument is that both men employed an assimilationist strategy that linked their identity to powerful social forces of their time, strategically restructuring their identity so that they could move into the most powerful centers of their social system—Paul navigating himself towards Rome and Herzl setting his gaze west even while physically moving east. My objective here is to demonstrate how these two Jewish figures used Christianity and Zionism, respectively, to assimilate towards those who hold real power, each of them appropriating the ideology of his movement in order to join the most powerful sector of his “world.” Yet I also intend to demonstrate that, while they both shared a desire to assimilate to power, the strategies they implemented to reach their goals were radically different: Paul using a universalistic discourse, what I shall call “Israel in the spirit,” whereas Herzl chose the particularistic discourse of “Israel in the flesh.” This is due, I argue, to the fact that both of these great historical figures were reacting to the social and political forces of their times, Paul to the centripetal forces of ancient world-empires and Herzl to the centrifugal forces of the modern world-system.

  1. MITO E CIÊNCIA NAS INTERPRETAÇÕES SOBRE PAUL VIDAL DE LA BLACHE

    Directory of Open Access Journals (Sweden)

    Guilherme Ribeiro

    2014-01-01

    Full Text Available This article discusses some of the main interpretations of Paul Vidal de la Blache’s geography through a historical and epistemological analysis. The purpose is take back his legacy at the beginning of XXIth century. In this sense, the most essential topics are considered: the false debate possibilism-determinism ; the role of the geopolitic ; the regional scale, and the positivism.

  2. Steward of Headwaters: U.S. Army Corps of Engineers, St. Paul District, 1975-2000

    Science.gov (United States)

    2012-01-01

    to their shells, thereby preventing them from migrating or burrowing .73 The St. Paul District initiated a monitoring process of the zebra mussel at...P ro je ct s 4 104 Strong Move, 13 February 1997, File LaFarge Ho Chunk, Box 6410, SPDAR; Ron Wilber to Larry Garvin, HoChunk Researcher, 10...July 1987, File Congressional Correspondence, Box 6412, SPDAR. 39 Larry and Diane Uhlir to Mr. Gregg Struss, Resource Manager, Gull Lake Recreation

  3. social equality and christian life in paul's first letter to the corinthians

    African Journals Online (AJOL)

    Schmeller 1995:92ff.). In this letter, Paul contends with theologically motivated schisms .... Ἰουδαῖοι and Ἕλλην embody, in their equality, certain attitudes (also in the .... but as a salvific ownership change with Christ as the new patron.20 The ... concept of the adult male, who is rational, moderate, and able to transcend.

  4. MSA Mimic? Rare Occurrence of Anti-Hu Autonomic Failure and Thymoma in a Patient with Parkinsonism: Case Report and Literature Review

    Directory of Open Access Journals (Sweden)

    Vito A. G. Ricigliano

    2018-01-01

    Full Text Available Thymoma is a tumor originating from thymic gland, frequently manifesting with paraneoplastic neurological disorders. Its association with paraneoplastic dysautonomia is relatively uncommon. Here, we describe the challenging case of a 71 year-old female who developed subacute autonomic failure with digestive pseudo-obstruction, dysphagia, urinary tract dysfunction and orthostatic hypotension complicating an underlying extrapyramidal syndrome that had started 3 months before hospital admission. Autonomic symptoms had 2-month course and acutely worsened just before and during hospitalization. Combination of severe dysautonomia and parkinsonism mimicked rapidly progressing multiple system atrophy. However, diagnostic exams showed thymic tumor with positive anti-Hu antibodies on both serum and cerebrospinal fluid. Complete response of dysautonomia to immunoglobulins followed by thymectomy confirmed the diagnosis of anti-Hu-related paraneoplastic neurological syndrome. With regards to extrapyramidal symptoms, despite previous descriptions of paraneoplastic parkinsonism caused by other antineuronal antibodies, in our case no relation between anti-Hu and parkinsonism could be identified. A literature review of published reports describing anti-Hu positivity in thymic neoplasms highlighted that a definite autonomic disease due to anti-Hu antibodies is extremely rare in patients with thymoma but without myasthenia gravis, with only one case published so far.

  5. Comparison between two treatment protocols with recombinant Human Erythropoietin (rHuEpo in the treatment of late anemia in neonates with Rh-Isoimmunization

    Directory of Open Access Journals (Sweden)

    A.A. Zuppa

    2012-08-01

    Full Text Available Objectve. The Rh-hemolytic disease can lead to a late anemia by hemolytic and hyporigenerative mechanism. We compared the effectiveness of rHuEPO in two care protocols that differ for doses of rHuEPO administrated and for timing of administration. Methods. A cohort of 14 neonates was investigated. The neonates were treated with two different protocols. Protocol A: a dose of 200 U/kg/day of rHuEpo administered subcutaneously starting from the end of the second week of life; Protocol B: a dose of 400 U/kg/day of rHuEpo administered subcutaneously starting from the end of the first week of life. Results. The hematocrit values in the protocol A group decreased during treatment (32,5% vs 25,2%, whereas the hematocrit value in protocol B group remained almost stable (38,7% vs 42,8%. The mean numbers of platelets remained stable in both groups while neutrophils increased in protocol A group and decreased in protocol B (p<0,05. Reticulocyte count increased during treatment in both groups, although only in protocol B group it was statistically significative (p<0,05. Conclusions. Our results suggest a similar efficacy between the two treatment protocols. Increasing doses of rHuEPO do not seem enhancing their effectiveness and the incidence of side effects.

  6. Effect of the synthetic cannabinoid HU-210 on quorum sensing and on the production of quorum sensing-mediated virulence factors by Vibrio harveyi.

    Science.gov (United States)

    Soni, Divya; Smoum, Reem; Breuer, Aviva; Mechoulam, Raphael; Steinberg, Doron

    2015-08-12

    Bacterial populations communicate through the cell density-dependent mechanism of quorum sensing (QS). Vibrio harveyi, one of the best studied model organisms for QS, was used to explore effects of the synthetic cannabinoid HU-210 on QS and different QS-regulated physiological processes in bacteria. Analysis of QS-regulated bioluminescence in wild-type and mutant strains of V. harveyi revealed that HU-210 affects the autoinducer-2 (AI-2) pathway, one of three known QS cascades of V. harveyi. Furthermore, QS-mediated biofilm formation and swimming motility in the mutant strain BB152 (AI-1(-), AI-2(+)) were significantly reduced in the presence of HU-210. HU-210 inhibited QS-mediated virulence factor production without any inhibitory effect on bacterial growth. It also alters the expression of several genes, which are regulated by QS, specifically downregulating the genes of the AI-2 QS cascade. First evidence is being provided for interference of bacterial signal-transduction systems by a synthetic cannabinoid. The effect of HU-210 was specific to the AI-2 cascade in V. harveyi. AI-2 is known as a "universal autoinducer" and interference with its activity opens a broad spectrum of applications for synthetic cannabinoids in future research as a potential anti-QS agent.

  7. Creator of Economic Opera, Founder and Reformer of Economic School – the Rector Paul Bran

    Directory of Open Access Journals (Sweden)

    Ghenadie Ciobanu

    2014-05-01

    Full Text Available Phd. Prof. Paul Bran (1940-2006, during the mandates of rector of the Bucharest University of Economic Studies (1996-2004 and beyond, although financier proved close to the Faculty of Commerce. In 2001, at the jubilee of the uninterrupted operation of the faculty, he stated: We join alumni, students and professors of the Faculty of Commerce to pay tribute to the work of learning and education that takes place here and to honor those who have established and then strengthened higher economic education in trade, marketing, tourism and commodity. I am convinced that the reputation of the Bucharest University of Economic Studies is due mainly to the quality of the activities taking place in departments and laboratories of the Faculty of Commerce.” On another occasion, the dedication on a book, he wrote: “Because tourism lives by money and money through tourism.” There are only two instances, seemingly unimportant, but which can be multiplied to the whole of his professional career of over four decades, and they shows us the Professor and Rector Paul Bran – both charismatic and effective – as a friend of the Faculty of Commerce. “Sincere congratulations and best wishes on the first issue of the journal Amfiteatru Economic,” said Rector Paul Bran, visionary, on the cover of the first issue of our publication, in 1999.

  8. John Paul II in the face of the reality of Auschwitz

    Directory of Open Access Journals (Sweden)

    Stanisław Wronka

    2014-06-01

    Full Text Available In the context of the canonization of John Paul II, the author reflects on his experience of the concentration camp at Auschwitz. It is a difficult experience, therefore it can more reveal the Pope as a man and a pastor, his way of thinking and perceiving reality. Through canonization this way is indicated to us as a pattern. John Paul came often to Auschwitz, where he saw the place of denial of God and man, but also a place of victory of man over contempt, hatred and death through faith in God, which generates love for Him and for man. The symbol of such a victory is St. Maximilian Maria Kolbe, martyr of love that as Christ gave his life for the fellow prisoner Francis Gajowniczek. In this heroic deed – in the opinion of the Pope – Christ himself was present, so the camp at Auschwitz is not only hell on earth, but also the Golgotha of our times, the cemetery of the martyrs, the sanctuary of the patron of difficult century. Pope John Paul II arrived there to pray and make a reflection on the contemporary man’s condition, who in Christ the Redeemer can still conquer evil with good and to build the peace based on respect for the rights of person and nations.

  9. Valuable books from the library of Paul Gore (Identification and/or inventory of sources

    Directory of Open Access Journals (Sweden)

    Maria Danilov

    2013-12-01

    Full Text Available Paul Gore (1875-1927 - an outstanding figure of the socio-political, scientific and cultural life of Bessarabia at the beginning of 20th century, was also known among his contemporaries as a keen collector of old and rare books. Undoubtedly, the most valuable part of the library of Paul Gore consisted of books on the history of Bessarabia. Documents from the National Archives of the Republic of Moldova in Chişinău confirm that he inherited a large part of books from his father Gheorghe Gore (1839-1909. A study of the Paul Gore Fund at the National Archives of Romania in Bucharest gave us a lot of documentary evidence of the destiny of this Bessarabian noble library, which later became a property of the King Ferdinand Fund. However, the fate of its most valuable part - books on the history of Bessarabia, consisted of 651 units of the total number of 6456 volumes - is still unknown.

  10. A retrospective diagnosis of epilepsy in three historical figures: St Paul, Joan of Arc and Socrates.

    Science.gov (United States)

    Muhammed, Louwai

    2013-11-01

    It has been suggested that undiagnosed epilepsy profoundly influenced the lives of several key figures in history. Historical sources recounting strange voices and visions may in fact have been describing manifestations of epileptic seizures rather than more supernatural phenomena. Well-documented accounts of such experiences exist for three individuals in particular: Socrates, St Paul and Joan of Arc. The great philosopher Socrates described a 'daimonion' that would visit him throughout his life. This daimonion may have represented recurrent simple partial seizures, while the peculiar periods of motionlessness for which Socrates was well known may have been the result of co-existing complex partial seizures. St Paul's religious conversion on the Road to Damascus may have followed a temporal lobe seizure which would account for the lights, voices, blindness and even the religious ecstasy he described. Finally, Joan of Arc gave a detailed narrative on the voices she heard from childhood during her Trial of Condemnation. Her auditory hallucinations appear to follow sudden acoustic stimuli in a way reminiscent of idiopathic partial epilepsy with auditory features. By analysing passages from historical texts, it is possible to argue that Socrates, St Paul and Joan of Arc each had epilepsy.

  11. [Rethinking ethics with Paul Ricœur. Nursing: between responsibility, care and justice].

    Science.gov (United States)

    Svandra, Philippe

    2016-03-01

    In this article, the purpose is less praising Paul Ricoeur's work than enlightening how the reader may actually find some practical, even operative help in this philosophical thought. This is particularly true regarding the fields of medicine and care. Paul Ricœur is now worldwide renowned as a major philosophical figure of the 20th century, and with books such as "Oneself as another", he occupies a very peculiar place at the crossroads of phenomenology and hermeneutics. Through both these philosophical traditions, Paul Ricœur offers some narrative ethics which may greatly sustain caregivers in their reflexion. Yet, the aim of this article is to focus on this philosopher who invites us to inhabit and play a role in this world. The goal is also to bring out the pragmatic ethics that this thinker developed, based on Aristotelian and Kantian traditions. Then, this piece seeks to demonstrate how the three stages of Ricoeur's "petite éthique" (his "small ethics"), which are the self's aim "for the good life with and for others in just institutions" can shed some light on the ethical consideration of politicals and caregivers.

  12. EnviroAtlas - Minneapolis/St. Paul, MN - Meter-Scale Urban Land Cover (MULC) Data (2010)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Minneapolis-St. Paul, MN EnviroAtlas Meter-scale Urban Land Cover (MULC) data were generated from four-band (red, green, blue, and near infrared) aerial...

  13. Paul Ariste 1942. aasta vadja välitöömaterjalid kultuurikirjeldusliku allikana / Ergo-Hart Västrik

    Index Scriptorium Estoniae

    Västrik, Ergo-Hart

    2005-01-01

    1942. a. toimunud Eesti Rahva Muuseumi ekspeditsioonist Vadjamaale. Paul Ariste ekspeditsiooni materjalid - rahvaluuleüleskirjutused ja välitööpäevik on vaatluse all materjalis leiduva usundilise ja mütoloogilise ainese seisukohalt

  14. Center for Transportation Studies 24th annual transportation research conference, May 22-23, 2013, Saint Paul, Minnesota.

    Science.gov (United States)

    2013-05-01

    The University of Minnesotas Center for Transportation : Studies is pleased to present its 24th Annual Transportation : Research Conference, May 22-23, 2013. The conference will : be held at the Saint Paul RiverCentre, 175 West Kellogg : Boulevard...

  15. Surface Weather Observations Log Sheets from the USS John Paul Jones, April 12 - 23, 2004 (NODC Accession 0001512)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Meteorological data were collected using meteorological sensors from the USS JOHN PAUL JONES in the Northeast Pacific Ocean. Data were collected and recorded into...

  16. Development of flood-inundation maps for the Mississippi River in Saint Paul, Minnesota

    Science.gov (United States)

    Czuba, Christiana R.; Fallon, James D.; Lewis, Corby R.; Cooper, Diane F.

    2014-01-01

    Digital flood-inundation maps for a 6.3-mile reach of the Mississippi River in Saint Paul, Minnesota, were developed through a multi-agency effort by the U.S. Geological Survey in cooperation with the U.S. Army Corps of Engineers and in collaboration with the National Weather Service. The inundation maps, which can be accessed through the U.S. Geological Survey Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/ and the National Weather Service Advanced Hydrologic Prediction Service site at http://water.weather.gov/ahps/inundation.php, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the U.S. Geological Survey streamgage at the Mississippi River at Saint Paul (05331000). The National Weather Service forecasted peak-stage information at the streamgage may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, flood profiles were computed for the Mississippi River by means of a one-dimensional step-backwater model. The hydraulic model was calibrated using the most recent stage-discharge relation at the Robert Street location (rating curve number 38.0) of the Mississippi River at Saint Paul (streamgage 05331000), as well as an approximate water-surface elevation-discharge relation at the Mississippi River at South Saint Paul (U.S. Army Corps of Engineers streamgage SSPM5). The model also was verified against observed high-water marks from the recent 2011 flood event and the water-surface profile from existing flood insurance studies. The hydraulic model was then used to determine 25 water-surface profiles for flood stages at 1-foot intervals ranging from approximately bankfull stage to greater than the highest recorded stage at streamgage 05331000. The simulated water-surface profiles were then combined with a geographic information system digital elevation model, derived from high-resolution topography

  17. Development and Characterization of a Humanized Anti-HER2 Antibody HuA21 with Potent Anti-Tumor Properties in Breast Cancer Cells

    Directory of Open Access Journals (Sweden)

    Ruilin Li

    2016-04-01

    Full Text Available Human epidermal growth factor receptor 2 (HER2 is one of the most studied tumor-associated antigens for cancer immunotherapy. An engineered anti-HER-2 chimeric A21 antibody (chA21 is a chimeric antibody targeted to subdomain I of the HER2 extracellular domain. Here, we report the anti-tumor activity of the novel engineered monoclonal antibody humanized chA21 (HuA21 that targets HER2 on the basis of chA21, and we describe the underlying mechanisms. Our results reveal that HuA21 markedly inhibits the proliferation and migration of HER2-overexpressing breast cancer cells and causes enhanced antibody-dependent cell-mediated cytotoxicity potency against HER2-overexpressing tumor cells. In particular, HuA21, but not trastuzumab (Tra, markedly suppresses growth and enhances the internalization of the antibody in Tra-resistant BT-474 breast cancer cells. These characteristics are highly associated with the intrinsic ability of HuA21 to down-regulate HER2 activation and inhibit the extracellular signal-regulated kinase 1/2 (ERK1/2 and protein kinase B (Akt signaling pathways. Furthermore, the combination of HuA21 with Tra synergistically enhances the anti-tumor effects in vitro and in vivo and inhibits HER2 activation and the ERK1/2 and Akt signaling pathways. Altogether, our results suggest that HuA21 may represent a unique anti-HER2 antibody with potential as a therapeutic candidate alone or in combination with other anti-HER2 reagents in cancer therapy.

  18. A Comparative Study of Saint Paul and Fakhri Razi on Faith

    Directory of Open Access Journals (Sweden)

    Ghorban Elmi

    2014-09-01

    Full Text Available Faith has a central place in Abrahamic religions. Jewish, Christian and Moslem thinkers have conducted several studies of the notion of faith and offered different ideas. Fakhri Razi and Saint Paul, two thinkers from Islamic and Christian religious traditions, have commented on the matter at length and these comments and ideas are studied in this essay.    Paul the Apostle (died 64 AD is the most famous and influential Christian figure and is known as the second founder of Christianity. He has an indispensable role in formulating Christian doctrines. At first, he was a Jew and after the revelation of Jesus, converted to Christianity and dedicated himself to evangelism. The only credible reports and first hand sources about the lives and beliefs of Paul are the Acts of the Apostles and his letters and epistles in the Bible.    The background of the debate on faith should be sought for in the Old Testament. In the Old Testament, belief means trusting in God, relying on Him, and recognizing and acknowledging the special relationship that God has established with Israel. In the New Testament, belief has a significant position too. Faith in the New Testament is more epistemic and cognitive and means certain belief and conviction. According to Paul faith is the basic principle of Christianity and outstanding feature of Christians and the main cause of salvation. In the early Christianity, Paul offers the most extensive and most profound exposition of faith.    In defining faith, Paul uses Greek word «pistis» which means confidence, faith and trust. In definition of faith, he says: "Faith is the confidence that what we hope will be, and faith is the certainty of what we believe, although we are not able to see them "(Hebrews, 11/1. He mentions Abraham as a distinguished example for introducing true faith and faithful. Faith in Jesus means to trust or have confidence in Jesus Christ. According to Paul, faith is based on hope in things which have

  19. A Comparative Study of Saint Paul and Fakhri Razi on Faith

    Directory of Open Access Journals (Sweden)

    Hamed Nazarpour najafabadi

    2014-08-01

    Full Text Available Faith has a central place in Abrahamic religions. Jewish, Christian and Moslem thinkers have conducted several studies of the notion of faith and offered different ideas. Fakhri Razi and Saint Paul, two thinkers from Islamic and Christian religious traditions, have commented on the matter at length and these comments and ideas are studied in this essay.    Paul the Apostle (died 64 AD is the most famous and influential Christian figure and is known as the second founder of Christianity. He has an indispensable role in formulating Christian doctrines. At first, he was a Jew and after the revelation of Jesus, converted to Christianity and dedicated himself to evangelism. The only credible reports and first hand sources about the lives and beliefs of Paul are the Acts of the Apostles and his letters and epistles in the Bible.    The background of the debate on faith should be sought for in the Old Testament. In the Old Testament, belief means trusting in God, relying on Him, and recognizing and acknowledging the special relationship that God has established with Israel. In the New Testament, belief has a significant position too. Faith in the New Testament is more epistemic and cognitive and means certain belief and conviction. According to Paul faith is the basic principle of Christianity and outstanding feature of Christians and the main cause of salvation. In the early Christianity, Paul offers the most extensive and most profound exposition of faith.    In defining faith, Paul uses Greek word «pistis» which means confidence, faith and trust. In definition of faith, he says: "Faith is the confidence that what we hope will be, and faith is the certainty of what we believe, although we are not able to see them "(Hebrews, 11/1. He mentions Abraham as a distinguished example for introducing true faith and faithful. Faith in Jesus means to trust or have confidence in Jesus Christ. According to Paul, faith is based on hope in things which have

  20. TH-CD-207B-11: Multi-Vendor Phantom Study of CT Lung Density Metrics: Is a Reproducibility of Less Than 1 HU Achievable?

    Energy Technology Data Exchange (ETDEWEB)

    Chen-Mayer, H [National Institute of Standards & Technology, Gaithersburg, MD (United States); Judy, P [Brigham & Women’s Hospital, Boston, MA (United States); Fain, S [University of Wisconsin, Madison, WI (United States); Hoppel, B [Toshiba Medical Research Institute USA, Inc, Vernon Hills, IL (United States); Lynch, D [Nation Jewish Health, Denver, CO (United States); Fuld, M [Siemens Medical Solutions USA, Inc., Baltimore, MD (United States)

    2016-06-15

    Purpose: To standardize the calibration procedures of CT lung density measurements using low-density reference foams in a phantom, and to demonstrate a reproducibility of less than 1 HU for lung equivalent foam densities measured across CT vendor platforms and protocols. Methods: A phantom study was conducted on CT scanner models from 4 vendors at 100, 120, and 135/140 kVp and 1.5, 3, and 6 mGy dose settings, using a lung density phantom containing air, water, and 3 reference foams (indirectly calibrated) with discrete densities simulating a 5-cm slice of the human chest. Customized segmentation software was used to analyze the images and generate a mean HU and variance for each of the density for the 22 vendor/protocols. A 3-step calibration process was devised to remove a scanner-dependent parameter using linear regression of the HU value vs the relative electron density. The results were mapped to a single energy (80 keV) for final comparison. Results: The heterogeneity across vendor platforms for each density assessed by a random effects model was reduced by 50% after re-calibration, while the standard deviation of the mean HU values also improved by about the same amount. The 95% CI of the final HU value was within +/−1 HU for all 3 reference foam densities. For the backing lung foam in the phantom (served as an “unknown”), this CI is +/− 1.6 HU. The kVp and dose settings did not appear to have significant contributions to the variability. Conclusion: With the proposed calibration procedures, the inter-scanner reproducibility of better than 1 HU is demonstrated in the current phantom study for the reference foam densities, but not yet achieved for a test density. The sources of error are being investigated in the next round of scanning with a certified Standard Reference Material for direct calibration. Fain: research funding from GE Healthcare to develop pulmonary MRI techniques. Hoppel: employee of Toshiba Medical Research Institute USA

  1. Nivel de pobreza y estado nutricional asociados a parasitosis intestinal en estudiantes, Huánuco, Perú, 2010

    Directory of Open Access Journals (Sweden)

    César Gabriel Berto Moreano

    2013-10-01

    Full Text Available Introducción: Se ha encontrado una prevalencia alta de parasitosis en escolares de la amazonía; pese a ello, no hay estudios realizados que revisen su asociación con el nivel socioeconómico y estado nutricional. Objetivos: Determinar la relación entre nivel de pobreza y estado nutricional con la presencia de parásitos intestinales en estudiantes escolares del caserío Venenillo, Huánuco. Diseño: Estudio transversal-analítico. Lugar: Caserío de Venenillo, Huánuco. Participantes: Estudiantes escolares de la única institución educativa del centro poblado. Intervenciones: A 42 estudiantes se les realizó examen coproparasitológico mediante observación directa con lugol y técnica de sedimentación rápida de Lumbreras. El nivel de pobreza fue determinado mediante el índice de necesidades básicas insatisfechas (NBI; y el grado de desnutrición, por medio del índice de Waterlow. El análisis estadístico fue realizado mediante el coeficiente gamma de Goodman y Kruskal. Principales medidas de resultados: Relación de parasitosis intestinal con pobreza y estado nutricional. Resultados: Los parásitos intestinales estuvieron presentes en 97,6%. Se encontró asociación significativa entre el nivel de parasitismo y el nivel de pobreza (p=0,02; gamma=0,82. No se encontró asociación significativa entre nivel de desnutrición y parasitismo (p=0,77. Conclusiones: La parasitosis intestinal se asoció al nivel de pobreza, no así con el nivel de desnutrición en la población de estudio.

  2. Dieta de roedores sigmodontinos (Cricetidae en los bosques montanos tropicales de Huánuco, Perú

    Directory of Open Access Journals (Sweden)

    Maggie C. Noblecilla

    2013-06-01

    Full Text Available Se analizó el contenido estomacal de cinco especies de roedores sigmodontinos: Akodon orophilus, Microry-zomys altissimus, M. minutus, Thomasomys notatus yT. kalinowskii, procedentes de los bosques montanos de Huánuco, Perú (2564 - 3850 m de altitud. Concluimos que A. orophiluses insectívora por haber presentado un alto volumen de artrópodos (adultos y larvas en el contenido estomacal (90,1%; mientras que T. notatusy T. kalinowskiison principalmente herbívoras por el alto volumen de materia vegetal, 89% y 67,75% respectiva-mente; y que M. altissimusy M. minutusson omnívoras por presentar volúmenes similares tanto para vegetales como para artrópodos. Thomasomys kalinowskiies considerada generalista por la mayor amplitud de nicho (4,61, mientras A. orophiluses considerada especialista por el menor valor (1,70. Akodon orophilusmostró una preferencia por el consumo de artrópodos adultos al tener un bajo coeficiente de variación (CV= 20% y también un significativo aumento en el consumo de larvas de artrópodos en la época húmeda, siendo la única especie con variación estacional en la dieta. Por otro lado, la sobreposición de nicho fue menor a 0,75 en el 80% de los pares de especies comparados, indicando una baja similitud en la dieta. La mayor similitud en la dieta se observó entre M. altissimus- T. notatus(0,822 y M. minutus - T. kalinowskii(0,816. Se concluye que estos roedores sigmodontinos, simpátricos en los bosques montanos de Huánuco, exhiben dietas disímiles, probablemente como una estrategia para evitar o aminorar la competencia interespecífica.

  3. Paul Langevin

    Indian Academy of Sciences (India)

    tions not only in physics but also in various other fields such as chemistry, biology and ... the required tools for the development of t~e special theory of relativity and would ... During the second world war Langevin became a vocal anti-.

  4. O avesso do visível: poética de Paul Klee

    Directory of Open Access Journals (Sweden)

    Maria Beatriz da Rocha Lagôa

    2006-01-01

    Full Text Available O artista Paul Klee investiga os processos da forma, conjugando materiais e técnicas que tecem suas próprias relações. O que caracteriza sua obra é a compreensão da Modernidade, as correspondências com outras culturas e demais gêneros de expressão artística. O traço, não mediado pela referência à natureza, atua como instrumento de busca de uma forma mais livre, que se desdobra no tempo e no espaço, e exige a participação do espectador.El artista Paul Klee investiga los procesos de la forma, conjugando materiales y técnicas que tejem sus relaciones próprias. Lo que caracteriza su obra es la compreensión de la Modernidad, las correspondencias con otras culturas y otros géneros de expresión artística. El trazo, sin mediación por la referencia a la naturaleza, actua como instrumento de busca de una forma mas libre, que se desdobla en el tiempo y en el espacio, exigiendo la participación del espectador.Paul Klee investigates the process of form, conjugating materials and techniques that weave their own relations. The artist understands the Modernity, its correspondences with the other cultures and means of artistic expression. The line, non mediated by references to nature, acts as an instrument in the search for a freer form, unfolding through space and time, and demanding the participation of the viewer.

  5. [Jean-Louis-Paul Denucé (1824-1889): A forgotten pioneer of plastic surgery].

    Science.gov (United States)

    Marck, K W; Martin, D

    2016-02-01

    The authors propose to define as main characterization of plastic reconstructive surgery the conceptual thinking that leads to a rational choice of an operative treatment. Conceptual thinking in plastic surgery started halfway the nineteenth century with the first schematic representations of the operative procedures available at that time, in which Von Ammon and Baumgarten, Szymanowski and Denucé played a prominent role. These four authors and their works are presented with special attention for the less known of them, Jean-Paul Denucé, surgeon in Bordeaux. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  6. Experimental investigation of the stability diagram for Paul traps in the case of praseodymium ions

    International Nuclear Information System (INIS)

    Koczorowski, W.; Szawiola, G.; Walaszyk, A.; Buczek, A.; Stefanska, D.; Stachowska, E.

    2006-01-01

    The present paper describes an investigation of non-linear resonances of praseodymium ion clouds stored in a Paul trap as a function of the storage parameters. These have been observed in traps with different ring electrode diameters. In these different traps the resonances occur for different values of the operating parameters. Discrepancies with the approximation model for one ion have been found. The intensity of the fluorescence signal and the Doppler half width have been recorded as a function of one of the storage parameters: q. We use our results to optimize the fluorescence signal of the stored ions, which is especially useful in the case of the double-resonance method.

  7. International recognition for ageing research: John Scott Award-2014 to Leonard Hayflick and Paul Moorhead

    OpenAIRE

    Rattan, Suresh

    2014-01-01

    It is with great pleasure and pride that we share the news of the award of the 2014 “City of Philadelphia John Scott Award”, to Dr. Leonard Hayflick and Dr. Paul Moorhead, for their research on ageing. The press release announcing the award states that: “from the first awarded in 1822, the Award is the oldest scientific award in the United States and, as a legacy to Benjamin Franklin, they are in the historic company of past winners who include Marie Curie, Thomas Edison, Jonas Salk, Irving L...

  8. Measurement Of The β-ν Correlation In 6He Using A Transparent Paul Trap

    International Nuclear Information System (INIS)

    Lienard, E.; Ban, G.; Darius, G.; Durand, D.; Flechard, X.; Herbane, M.; Labalme, M.; Mauger, F.; Mery, A.; Naviliat-Cuncic, O.; Rodriguez, D.

    2006-01-01

    The angular correlation between the electron and the neutrino in nuclear β-decay constitutes a sensitive observable to search for the existence of exotic couplings in the weak interaction. In this contribution, we describe the progress of the LPCTrap experiment, devoted to measure the β-ν angular correlation in the pure Gamow-Teller (GT) decay of 6He using a transparent Paul trap. We present a first coincidence spectrum, obtained during the commissioning run, which is the first β-recoil coincidence measurement obtained from any ion trap

  9. A history of gravity: An introduction to the epistemology of Paul Feyerabend

    Science.gov (United States)

    Rodrigues, Danilo Miranda

    2015-08-01

    The goal of this work is to show an historical introduction to epistemology of Paul Feyerabend and the importance of his concept of epistemological anarchism for education.Feyerabend defended that different and even contradictory theories must be used in education, this multiplicity of possible explanations for natural phenomena is important to express the real development of science.There are many different explanations for the fall of bodies, since the "natural places" in Aristotle until the Newtonian Gravitation or the General Relativity. The contact with many different explanations has as important contribution for the learning of Astronomy.

  10. Identidade narrativa e identidade pessoal. Uma abordagem da filosofia de Paul Ricoeur

    OpenAIRE

    Fernandes, Sara Margarida de Matos Roma

    2009-01-01

    O presente artigo tem o objectivo duplo de reflectir sobre o conceito de identidade narrativa no pensamento de Paul Ricœur e o de avaliar a sua contribuição para a resolução do problema filosófico da identidade pessoal. Para o concretizar, o artigo procurará desenvolver as teses seguintes: 1) a identidade narrativa resulta da permanente dialéctica entre o carácter (mesmidade, idem) e a ipseidade (constância, ipse), ou seja, entre a capacidade do sujeito se referir continuamente a si durante a...

  11. Kepler's relation to the Jesuits-A study of his correspondence with Paul Guldin.

    Science.gov (United States)

    Schuppener, Georg

    1997-12-01

    First, this article provides a survey of the kind of relationship that existed between Kepler and the Jesuits. Afterwards, it is pondered upon the likelihood of their having been in direct contact with each other while Kepler lived in Prague. The second part of the article is devoted to an investigation into the correspondence between Kepler and Paul Guldin as an example. Thus, the paper describes the key issues of those letters and concludes from this Guldin's attitude to Kepler and the resulting commitment to Kepler's affairs. Finally, the article examines whether the assumption that Kepler and Guldin later discontinued their correspondence intensionally is verifiable and plausible.

  12. Theological reflections on donation after circulatory death: the wisdom of Paul Ramsey and Moshe Feinstein.

    Science.gov (United States)

    Jotkowitz, A

    2008-10-01

    Due to the worldwide shortage of organs for transplantation, there has been an increased use of organs obtained after circulatory death alone. A protocol for this procedure has recently been approved by a major transplant consortium. This development raises serious moral and ethical concerns. Two renowned theologians of the previous generation, Paul Ramsey and Moshe Feinstein, wrote extensively on the ethical issues relating to transplantation, and their work has much relevance to current moral dilemmas. Their writings relating to definition of death, organ transplantation and the care of the terminally ill are briefly presented, and their potential application to the moral problem of organ donation after circulatory death is discussed.

  13. Narrative Refiguration of Social Events: Paul Ricoeur's Contribution to Rethinking the Social

    Directory of Open Access Journals (Sweden)

    Anna Borisenkova

    2010-12-01

    Full Text Available The analysis of events has been a central issue for social sciences for a long time. The problem of an event's definition and distinction is still at stake in sociological debates. The purpose of this paper is to demonstrate the contribution of Paul Ricoeur's narrative theory to social events studies. First, this is done through the explication of the concept in the framework of narrative approach. Secondly, the paper highlights the narrative's capacity of 'refiguring' the social by re-describing social events, subordinating their succession to the logic of story-telling and transforming temporal characteristics as well. Apart from some insights, interpretative explanations and illustrations the paper provides critical arguments concerning the limitations of Paul Ricoeur's narrative approach with respect to sociological event-analysis.     L'analyse des événements a toujours été une question centrale pour l'histoire et les sciences sociales. Le problème de la définition et de la distinction des événements est encore en jeu dans les débats sociologiques contemporains. L'objectif de cet article est de s'attarder sur la contribution de la théorie de Paul Ricœur aux études des événements sociaux.  Après avoir montré les limites d'une conception impersonnelle de l'événement, l'auteur se penche sur la solution narrative proposée par Ricœur, à savoir la capacité du récit à “refigurer” du Social par la re-description des événements sociaux. Il s'agit de soumettre la logique de la succession temporelle à la logique de la narration. Tout en rendant justice à la valeur heuristique de telles analyses (à travers une série d'explicitations et d'illustrations, l'article pointe les limites de l'approche narrative de Paul Ricœur au regard des analyses sociologique des événements.  

  14. Observation of a structural transition for coulomb crystals in a linear Paul trap

    DEFF Research Database (Denmark)

    Kjærgaard, N.; Drewsen, M.

    2003-01-01

    A structural transition for laser cooled ion Coulomb crystals in a linear Paul trap just above the stability limit of parametrically resonant excitation of bulk plasma modes has been observed. In contrast to the usual spheroidal shell structures present below the stability limit, the ions arrange...... in a "string-of-disks" configuration. The spheroidal envelopes of the string-of-disks structures are in agreement with results from cold fluid theory usually valid for ion Coulomb crystals if the ion systems are assumed to be rotating collectively....

  15. A floresta geométrica de Paul Claudel: fronteira entre dois mundos.

    Directory of Open Access Journals (Sweden)

    Vera Beatriz Siqueira

    Full Text Available resumo O artigo parte da análise do balé O homem e seu desejo, criado por Paul Claudel (poema plástico, Darius Milhaud (música e Audrey Parr (cenografia e figurino quando estavam no Rio de Janeiro entre 1917 e 1918. A ideia básica é pensar essa obra como parte integrante dos diálogos interculturais que fundam a modernidade global do início do século XX, investigando o papel desempenhado pela cultura e pela natureza brasileira no projeto de Claudel de articulação entre vanguarda, classicismo e primitivismo.

  16. Positioning of the rf potential minimum line of a linear Paul trap with micrometer precision

    DEFF Research Database (Denmark)

    Herskind, Peter Fønss; Dantan, Aurélien; Albert, Magnus

    2009-01-01

    We demonstrate a general technique to achieve a precise radial displacement of the nodal line of the radiofrequency (rf) field in a linear Paul trap. The technique relies on the selective adjustment of the load capacitance of the trap electrodes, achieved through the addition of capacitors...... to the basic resonant rf circuit used to drive the trap. Displacements of up to ~100 µm with micrometer precision are measured using a combination of fluorescence images of ion Coulomb crystals and coherent coupling of such crystals to a mode of an optical cavity. The displacements are made without measurable...

  17. St Paul fracture zone intratransform ridge basalts (Equatorial Atlantic): Insight within the mantle source diversity

    Science.gov (United States)

    Hemond, C.; Brunelli, D.; Maia, M.; Prigent, S.; Sichel, S. E.

    2017-12-01

    The St Paul Transform System offsets by 630 km the Equatorial Mid Atlantic Ridge at 1° N. It consists of four Major faults separating three intra transform ridge axes. Volcanic glassy samples were collected inside two intratransform ridge (ITR) segments during the COLMEIA cruise (Maia et al ; 2016) and samples from the third ITR available from a previous cruise ST PAUL (Hékinian et al. 2000). Major, trace elements and Hf, Pb, Sr and Nd isotopes were determined on selected hand picked glass chips. Few glassy samples recovered and analysed from abyssal hill samples open a time window of about 4.5 million years in the chemistry of the northern ITR. Results show that all samples are basaltic in composition but trace elements display contrasting images for the three ITR. The northern ITR samples are all light REE and highly incompatible enriched and are E-MORB; the central ITR samples display rather flat REE pattern with a level on enrichment of the HREE higher than the other two ITR and are T-MORB. Southern ITR samples are more heterogeneous N-MORB to T-MORB with a lower level of HREE. Isotopes reveal that the ITRs sample distinct mantle sources. In various isotope plans, the northern ITR samples plot together with published results from the MAR directly north of the St Paul F.Z. Therefore they exhibit some flavor of the Sierra Leone hotspot interacting with the MAR at 1.7°N. Central and southern ITR samples have very distinct composition from the northern ITR but resemble each other. However, for identical 206Pb/204Pb ratios, central ITR has slightly but significantly higher 207Pb/204Pb and 208Pb/204Pb, also higher 143Nd/144Nd for a given 87Sr/86Sr. Southern ITR is in chemical continuity of the MAR southward. So that central ITR samples display a rather specific composition. Off axis samples corresponding to the activity of the northern ITR up to 4.6 m.y. show that the hotspot contribution was even bigger on the spreading axis than today and might be fading with

  18. Jean-Paul Martinon, ed. - The Curatorial: A Philosophy of Curating

    Directory of Open Access Journals (Sweden)

    Sofia Romualdo

    2015-12-01

    Full Text Available In the words of Jean-Paul Martinon, this book’s editor, The Curatorial: A Philosophy of Curating originated from a “wish to talk about curating”, the same wish that led to the creation, in 2006, of a practice-led PhD programme at Goldsmiths College, called Curatorial/Knowledge. The anthology features contributions from tutors, guest speakers and students, all of whom delve into what “the curatorial” is and what it might mean in the future. Curating, or the act of organizing exhibitions, paral...

  19. Observation of a structural transition for Coulomb crystals in a linear Paul trap

    International Nuclear Information System (INIS)

    Kjaergaard, Niels; Drewsen, Michael

    2003-01-01

    A structural transition for laser cooled ion Coulomb crystals in a linear Paul trap just above the stability limit of parametrically resonant excitation of bulk plasma modes has been observed. In contrast to the usual spheroidal shell structures present below the stability limit, the ions arrange in a 'string-of-disks' configuration. The spheroidal envelopes of the string-of-disks structures are in agreement with results from cold fluid theory usually valid for ion Coulomb crystals if the ion systems are assumed to be rotating collectively

  20. Asthenospheric percolation of alkaline melts beneath the St. Paul region (Central Atlantic Ocean)

    Science.gov (United States)

    Brunelli, Daniele; Seyler, Monique

    2010-01-01

    Two peridotite suites collected by submersible in the equatorial Atlantic Ocean (Hekinian et al., 2000) were studied for textures, modes, and in situ major and trace element compositions in pyroxenes. Dive SP12 runs along the immersed flank of the St. Peter and Paul Rocks islets where amphibole-bearing, ultramafic mylonites enriched in alkalies and incompatible elements are exposed (Roden et al., 1984), whereas dive SP03 sampled a small intra-transform spreading centre situated about 370 km east of the St. Peter and Paul Rocks. Both suites are characterized by undeformed, coarse-grained granular textures typical of abyssal peridotites, derived from residual mantle after ˜ 15% melting of a DMM source, starting in the garnet stability field. Trace element modelling, textures and lack of mineral zoning indicate that the residual peridotites were percolated, reacted and refertilized by ˜ 2.6% partially aggregated melts in the uppermost level of the melting region. This relatively large amount of refertilization is in agreement with the cold and thick lithosphere inferred by previous studies. Freezing of trapped melts occurred as the peridotite entered the conductive layer, resulting in late-stage crystallization of olivine, clinopyroxene, spinel, ± plagioclase. Chondrite-normalized REE patterns in clinopyroxenes from SP03 indicate that they last equilibrated with (ultra-) depleted partial melts. In contrast, REE concentrations in clinopyroxenes from SP12 display U and S shaped LREE-enriched patterns and the calculated compositions of the impregnating melts span the compositional range of the regional basalts, which vary from normal MORB to alkali basalt sometimes modified by chromatographic fractionation with no, or very limited, mineral reaction. Thus the mylonitic band forming the St. Peter and St. Paul Rocks ridge is not a fragment of subcontinental lithospheric mantle left behind during the opening of the Central Atlantic, nor the source of the alkaline basalts

  1. Short communication. Employment of molecular markers to develop tetraploid “supermale” asparagus from andromonoecious plants of the landrace ‘Morado de Huétor’

    Directory of Open Access Journals (Sweden)

    Jose J. Regalado

    2014-10-01

    Full Text Available The aim of this work was the development of new “supermale” genotypes retaining the highest genetic diversity possible of the tetraploid asparagus landrace ‘Morado de Huétor’. The elite andromonoecious male HT664 of the ‘Morado de Huétor’ asparagus landrace and the andromonoecious hybrid male HC027, obtained by crossing between this landrace and a commercial cultivar of Asparagus officinalis, were selected for self-pollination to produce possible “supermales” with genes of ‘Morado de Huétor’ (SMHT. To confirm the hybrid nature of HC027, we characterized this genotype with EST-SSR (Expressed Sequence Tag-derived Simple Sequence Repeats markers. We also adopted the sex-linked marker Asp1-T7 for sex determination in ‘Morado de Huétor’ and the resulting hybrids between this landrace and other commercial cultivars. Asp1-T7 marker was used for the selection and genotyping of SMHT. “All-male” cultivars with a different genetic background can be generated by crossing females with these new “supermale” genotypes, and the agronomical traits of these new cultivars would be very different from the “all-male” cultivars currently available in the market, making them extremely interesting for asparagus breeding programs.

  2. Proteínas del huésped incorporadas en el Virus de la Inmunodeficiencia Humana tipo 1 (VIH-1

    Directory of Open Access Journals (Sweden)

    Dayane Canedo de León

    2008-01-01

    Full Text Available El Virus de la Inmunodeficiencia Humana (VIH, como la mayoría de los virus envueltos, toma esta estructura cuando abandona la célula infectada. El virus adquiere durante este proceso, junto con fragmentos de la membrana de la célula huésped, proteínas derivadas de la membrana celular como parte integral de la envoltura madura. Estos componentes de la envoltura viral derivados del huésped pueden ejercer algunos efectos en el ciclo de vida del virus, en la interacción virus-célula, especialmente en la respuesta del huésped a sus propias proteínas incorporadas por el virus y, finalmente, en la patogénesis de la enfermedad inducida por el virus. El rol de estas proteínas ha recibido cada día más atención, específicamente en la importancia que puedan tener en el proceso infeccioso viral y en le desarrollo del Síndrome de la Inmunodeficiencia Adquirida (SIDA. El objetivo de este artículo es hacer una revisión de las proteínas del huésped que son incorporadas por el VIH, haciendo énfasis en el rol potencial de estas proteínas en la patogénesis del SIDA.

  3. Proposed Methodology for Application of Human-like gradual Multi-Agent Q-Learning (HuMAQ) for Multi-robot Exploration

    International Nuclear Information System (INIS)

    Ray, Dip Narayan; Majumder, Somajyoti

    2014-01-01

    Several attempts have been made by the researchers around the world to develop a number of autonomous exploration techniques for robots. But it has been always an important issue for developing the algorithm for unstructured and unknown environments. Human-like gradual Multi-agent Q-leaming (HuMAQ) is a technique developed for autonomous robotic exploration in unknown (and even unimaginable) environments. It has been successfully implemented in multi-agent single robotic system. HuMAQ uses the concept of Subsumption architecture, a well-known Behaviour-based architecture for prioritizing the agents of the multi-agent system and executes only the most common action out of all the different actions recommended by different agents. Instead of using new state-action table (Q-table) each time, HuMAQ uses the immediate past table for efficient and faster exploration. The proof of learning has also been established both theoretically and practically. HuMAQ has the potential to be used in different and difficult situations as well as applications. The same architecture has been modified to use for multi-robot exploration in an environment. Apart from all other existing agents used in the single robotic system, agents for inter-robot communication and coordination/ co-operation with the other similar robots have been introduced in the present research. Current work uses a series of indigenously developed identical autonomous robotic systems, communicating with each other through ZigBee protocol

  4. The monomeric form of Neisseria DNA mimic protein DMP19 prevents DNA from binding to the histone-like HU protein

    Science.gov (United States)

    Ko, Tzu-Ping; Liao, Yi-Ting; Hsu, Kai-Cheng

    2017-01-01

    DNA mimicry is a direct and effective strategy by which the mimic competes with DNA for the DNA binding sites on other proteins. Until now, only about a dozen proteins have been shown to function via this strategy, including the DNA mimic protein DMP19 from Neisseria meningitides. We have shown previously that DMP19 dimer prevents the operator DNA from binding to the transcription factor NHTF. Here, we provide new evidence that DMP19 monomer can also interact with the Neisseria nucleoid-associated protein HU. Using BS3 crosslinking, gel filtration and isothermal titration calorimetry assays, we found that DMP19 uses its monomeric form to interact with the Neisseria HU dimer. Crosslinking conjugated mass spectrometry was used to investigate the binding mode of DMP19 monomer and HU dimer. Finally, an electrophoretic mobility shift assay (EMSA) confirmed that the DNA binding affinity of HU is affected by DMP19. These results showed that DMP19 is bifunctional in the gene regulation of Neisseria through its variable oligomeric forms. PMID:29220372

  5. Investigation of the HU-density conversion method and comparison of dose distribution for dose calculation on MV cone beam CT images

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Min Joo; Lee, Seu Ran; Suh, Tae Suk [Dept. of Biomedical Engineering, The Catholic University of Korea, Bucheon (Korea, Republic of)

    2011-11-15

    Modern radiation therapy techniques, such as Image-guided radiation therapy (IGRT), Adaptive radiation therapy (ART) has become a routine clinical practice on linear accelerators for the increase the tumor dose conformity and improvement of normal tissue sparing at the same time. For these highly developed techniques, megavoltage cone beam computed tomography (MVCBCT) system produce volumetric images at just one rotation of the x-ray beam source and detector on the bottom of conventional linear accelerator for real-time application of patient condition into treatment planning. MV CBCT image scan be directly registered to a reference CT data set which is usually kilo-voltage fan-beam computed tomography (kVFBCT) on treatment planning system and the registered image scan be used to adjust patient set-up error. However, to use MV CBCT images in radiotherapy, reliable electron density (ED) distribution are required. Patients scattering, beam hardening and softening effect caused by different energy application between kVCT, MV CBCT can cause cupping artifacts in MV CBCT images and distortion of Houns field Unit (HU) to ED conversion. The goal of this study, for reliable application of MV CBCT images into dose calculation, MV CBCT images was modified to correct distortion of HU to ED using the relationship of HU and ED from kV FBCT and MV CBCT images. The HU-density conversion was performed on MV CBCT image set using Dose difference map was showing in Figure 1. Finally, percentage differences above 3% were reduced depending on applying density calibration method. As a result, total error co uld be reduced to under 3%. The present study demonstrates that dose calculation accuracy using MV CBCT image set can be improved my applying HU-density conversion method. The dose calculation and comparison of dose distribution from MV CBCT image set with/without HU-density conversion method was performed. An advantage of this study compared to other approaches is that HU

  6. Proteomics reveal energy metabolism and mitogen-activated protein kinase signal transduction perturbation in human Borna disease virus Hu-H1-infected oligodendroglial cells.

    Science.gov (United States)

    Liu, X; Yang, Y; Zhao, M; Bode, L; Zhang, L; Pan, J; Lv, L; Zhan, Y; Liu, S; Zhang, L; Wang, X; Huang, R; Zhou, J; Xie, P

    2014-05-30

    Borna disease virus (BDV) is a neurotropic, non-cytolytic RNA virus which replicates in the cell nucleus targeting mainly hippocampal neurons, but also astroglial and oligodendroglial cells in the brain. BDV is associated with a large spectrum of neuropsychiatric pathologies in animals. Its relationship to human neuropsychiatric illness still remains controversial. We could recently demonstrate that human BDV strain Hu-H1 promoted apoptosis and inhibited cell proliferation in a human oligodendroglial cell line (OL cells) whereas laboratory BDV strain V acted contrariwise. Here, differential protein expression between BDV Hu-H1-infected OL cells and non-infected OL cells was assessed through a proteomics approach, using two-dimensional electrophoresis followed by matrix-assisted laser desorption ionization-time of flight tandem mass spectrometry. A total of 63 differential host proteins were identified in BDV Hu-H1-infected OL cells compared to non-infected OL cells. We found that most changes referred to alterations related to the pentose phosphate pathway, glyoxylate and dicarboxylate metabolism, the tricarboxylic acid (TCA) cycle, and glycolysis /gluconeogenesis. By manual querying, two differential proteins were found to be associated with mitogen-activated protein kinase (MAPK) signal transduction. Five key signaling proteins of this pathway (i.e., p-Raf, p-MEK, p-ERK1/2, p-RSK, and p-MSK) were selected for Western blotting validation. p-ERK1/2 and p-RSK were found to be significantly up-regulated, and p-MSK was found to be significantly down-regulated in BDV Hu-H1-infected OL cells compared to non-infected OL cell. Although BDV Hu-H1 constitutively activated the ERK-RSK pathway, host cell proliferation and nuclear translocation of activated pERK in BDV Hu-H1-infected OL cells were impaired. These findings indicate that BDV Hu-H1 infection of human oligodendroglial cells significantly perturbs host energy metabolism, activates the downstream ERK-RSK complex of

  7. Infección por Gnathostoma (Spirurida: Gnathostomatidae en Hoplias microlepis: prevalencia, correlación con la talla del pez, huéspedes e implicaciones para salud pública en Ecuador

    Directory of Open Access Journals (Sweden)

    Juan José Alava

    2009-12-01

    Conclusiones. La gnathostomiasis sigue siendo prevalente en la zona costera de Ecuador y el agente patógeno es aún encontrado en el huésped intermediario. Diversos mamíferos neotropicales estarían actuando como huésped reservorio definitivo en el ciclo biológico de Gnathostoma en Ecuador.

  8. Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome.

    Directory of Open Access Journals (Sweden)

    Olivia Hoffman

    Full Text Available A hallmark of acute respiratory distress syndrome (ARDS is accumulation of protein-rich edema in the distal airspaces and its removal is critical for patient survival. Previous studies have shown a detrimental role of Glycogen Synthase Kinase (GSK 3β during ARDS via inhibition of alveolar epithelial protein transport. We hypothesized that post-transcriptional regulation of GSK3β could play a functional role in ARDS resolution. To address this hypothesis, we performed an in silico analysis to identify regulatory genes whose expression correlation to GSK3β messenger RNA utilizing two lung cancer cell line array datasets. Among potential regulatory partners of GSK3β, these studies identified the RNA-binding protein ELAVL-1/HuR (Embryonic Lethal, Abnormal Vision, Drosophila-Like as a central component in a likely GSK3β signaling network. ELAVL-1/HuR is a RNA-binding protein that selectively binds to AU-rich elements of mRNA and enhances its stability thereby increasing target gene expression. Subsequent studies with siRNA suppression of ELAVL-1/HuR demonstrated deceased GSK3β mRNA and protein expression and improved clearance of FITC-albumin in A549 cells. Conversely, stabilization of ELAVL-1/HuR with the proteasome inhibitor MG-132 resulted in induction of GSK3β at mRNA and protein level and attenuated FITC-albumin clearance. Utilizing ventilator-induced lung injury or intra-tracheal installation of hydrochloric acid to induce ARDS in mice, we observed increased mRNA and protein expression of ELAVL-1/HuR and GSK3β. Together, our findings indicate a previously unknown interaction between GSK3β and ELAV-1 during ARDS, and suggest the inhibition of the ELAV-1- GSK3β pathways as a novel ARDS treatment approach.

  9. A single nucleotide polymorphism in the zona pellucida 3 gene is associated with the first parity litter size in Hu sheep.

    Science.gov (United States)

    Chong, Yuqing; Huang, Huarong; Liu, Guiqiong; Jiang, Xunping; Rong, Weiheng

    2018-03-31

    Zona pellucida 3 (ZP3) is a primary sperm receptor and acrosome reaction inducer. As a candidate gene, the ZP3 gene has been widely studied since it has great influence on reproductive traits in farm animals. However, little is known about the association between polymorphisms of the coding region of the ZP3 gene and the first parity litter size in Hu sheep. Therefore, the objective of this study was to identify single nucleotide polymorphisms (SNPs) of the ZP3 gene associated with the first parity litter size in Hu sheep. A total of 462 female Hu sheep were sampled to detect SNPs in the coding region of the ZP3 gene. Six SNPs were identified and the reliability of all estimated allele frequencies reached 0.9545 except for one locus (g.2293C > T). SNP (rs401271989) was identified as that involved in amino acid change (Ile → Leu). This amino acid was located at the beginning of a β-strand and outside of the ZP3 protein membrane, and it was most likely to be a ligand-binding site (the possibility was 0.917). At this locus, individuals with AC genotype had a larger litter size than those with CC genotype in the first parity (2.050 vs 1.727, p size in Hu sheep, and it may affect the function of ZP3 protein by impacting the secondary and tertiary protein structures. The present study demonstrates that SNP (rs401271989) could be used in marker-assisted selection of the first parity litter size in Hu sheep. Copyright © 2018 Elsevier B.V. All rights reserved.

  10. Paul trap experiment to simulate intense nonneutral beam propagation through a periodic focusing field configuration

    CERN Document Server

    Davidson, R C; Majeski, R; Qin, H; Shvets, G

    2001-01-01

    This paper describes the design concept for a compact Paul trap experimental configuration that fully simulates the collective processes and nonlinear transverse dynamics of an intense charged particle beam that propagates over large distances through a periodic quadrupole magnetic field. To summarize, a long nonneutral plasma column (L>=r sub p) is confined axially by applied DC voltages V[circ]=const. on end cylinders at z=+-L, and transverse confinement is provided by segmented cylindrical electrodes (at radius r sub w) with applied oscillatory voltages +-V sub 0 (t) over 90 deg. segments. Because the transverse focusing force is similar in waveform to that produced by a discrete set of periodic quadrupole magnets in a frame moving with the beam, the Paul trap configuration offers the possibility of simulating intense beam propagation in a compact experimental facility. The nominal operating parameters in the experimental design are: barium ions (A=137); plasma column length 2L=2 m; wall radius r sub w =10...

  11. An apology for dialogue: Claude Geffré reading Paul Tillich

    Directory of Open Access Journals (Sweden)

    Joe Marçal Gonçalves dos Santos

    2015-12-01

    Full Text Available The subject of this article is Claude Geffré’s reading on Paul Tillich’s thought in De Babel a Pentecostes: ensaios de teologia inter-religiosa. The author relies on Tillich’s theology to develop an “inter-religious dialogue hermeneutics” in order to answer to the challenge that religious pluralism poses to Christian theology today. The argument that Geffré finds is that just based on the Christological paradox, in light of the concept of “final revelation” and “ultimate concern”, Christian theology can respond to the religious pluralism without losing itself. The article presents two parts: firstly, an overview of Geffré’s book, focusing on the first session entitled Não há outro nome, where our object of study is found. Secondly, we analyse Tillich’s concepts developed by Geffré in this chapter, aiming to identify and characterize the main results of this reading and analyse them in light of Tillich’s referential work. In conclusion, we highlight the relevance of Paul Tillich’s theology to deal with the problem of religious pluralism, what is also demonstrated by Geffré. Besides, we consider a criticism of Gefreé’s proposal regarding an inter-religious theology based on the concept of ultimate concern, whose implication questions the use of this concept for an inter-religious theology, as its paradoxical nature is relativized.

  12. Temperature measurement of {sup 6}He{sup + } ions confined in a transparent Paul trap

    Energy Technology Data Exchange (ETDEWEB)

    Flechard, X., E-mail: flechard@lpccaen.in2p3.fr; Ban, G.; Durand, D.; Lienard, E.; Mauger, F. [Universite de Caen, LPC Caen, ENSICAEN (France); Mery, A. [Universite de Caen, CIMAP, CEA/CNRS/ENSICAEN (France); Naviliat-Cuncic, O. [Universite de Caen, LPC Caen, ENSICAEN (France); Rodriguez, D. [Universitad de Granada, Departamento de Fisica Atomica, Molecular y Nuclear (Spain); Velten, P. [Universite de Caen, LPC Caen, ENSICAEN (France)

    2011-07-15

    The LPCTrap setup is a transparent Paul trap dedicated to the measurement of the {beta}-{nu} correlation coefficient a{sub {beta}{nu}} in the {beta} decay of trapped radioactive nuclides. In a first experiment, the system has been used to record {approx}10{sup 5} coincidences between the {beta} particles and recoiling ions emitted from the decay of {sup 6}He{sup + } ions. The analysis of the collected data has already shown that the size of the {sup 6}He{sup + } ion cloud confined in the Paul trap is a critical parameter, potentially limiting the accuracy on the a{sub {beta}{nu}} measurement. We report here the precise determination of the trapped ion cloud temperature and size. This was performed by extracting the trapped ions toward a position sensitive micro channel plate detector at different phases of the RF driving field. We find a temperature T{sub exp} = 0.107(7) eV, consistent with the temperature values inferred using two other observables but 20% higher than the temperature T{sub sim} = 0.09 eV predicted by realistic simulations of the ions interacting with the H{sub 2} buffer gas.

  13. Protocol images for staging of gastric cancer in radiology Hospital San Vicente de Paul

    International Nuclear Information System (INIS)

    Jarquin Salvatierra, Estibaliz

    2010-01-01

    The realization of a protocol for the evaluation of imaging in the radiology service of Hospital San Vicente de Paul in the province of Heredia is considered a useful tool that allows a clear and simple communication with the rest of the interdisciplinary team that serves patients with gastric cancer. The adequate management of this disease is important for an assessment and standardized reporting of images to facilitate preoperative planning; because the number of diagnostic studies that should be performed for the detection once obtained the histological diagnosis to establish the staging. Prior knowledge of stage according to TNM (Tumor/Nodes/Metastasis) classification is essential. The initial assessment for radiological detection of gastric cancer was performed with gastroduodenal series with double contrast medium and fluoroscopic control. The establishment of a study effects required for routine is important and avoid underdiagnosis.The new Hospital San Vicente de Paul will have the tomographic assessment and trans abdominal ultrasound (USTA) essential to assess the presence of metastasis to peritoneum and solid organs, in addition to the adenomegaly suggesting neoplastic infiltration. (author) [es

  14. La vinculación investigación-docencia-sociedad: el caso de Paul Ehrenfest

    Directory of Open Access Journals (Sweden)

    Guzmán Díaz, Ricardo

    2012-09-01

    Full Text Available Resumen: El presente ensayo trata sobre el pensador Paul Ehrenfest, su labor científica, académica, social y humanística. Fue un científico comprometido y crítico con los cambios vertiginosos que vivió la física a principios del siglo pasado, y un profesor destacado, que ayudó a crear una escuela de física importante en Holanda cuya experiencia académica contribuyó a la formación de científicos que destacaron en sus disciplinas en las siguientes décadas. En sus últimos años fue precursor de la vinculación entre la universidad, la industria y las necesidades sociales.Abstract: This essay deals about Paul Ehrenfest and his scientific, academic, social and humanistic labor. He was a committed scientist and very critic of the rapid changes that physics experienced in the early last century, and an outstanding professor, who helped create an important Physics school in the Netherlands whose academic experience contributed to the training of scientists who excelled in their fields in the following decades. In his later years he pioneered the linkage between university, industry and social needs.

  15. Modelo de gestión cultural: Una experiencia con el Qhapaq Ñan en Huánuco

    Directory of Open Access Journals (Sweden)

    Denesy Palacios Jiménez

    2014-06-01

    Full Text Available Objetivos: Plantear el aprovechamiento del patrimonio cultural arqueológico del Qhapaq Ñan en Huánuco en condición de parque cultural, mediante un modelo eficiente de gestión cultural basada en la investigación, protección, conservación y uso social, para convertir a este lugar en un destino turístico y así contribuir con un proyecto no solo para salvaguardarlo sino también para incrementar los ingresos económicos y reducir los niveles de pobreza en la zona. Métodos: Se trata de un estudio que describe y recoge experiencias de gestión cultural respecto a cómo se aprovecha en otros sitios el legado o patrimonio cultural arqueológico, tanto en el ámbito mundial como nacional. La investigación fue cuantitativa y cualitativa, con un alcance correlacional. Se usó el diseño descriptivo, comparativo, analítico, histórico, deductivo. Resultados: El estudio plantea la necesidad de optimizar los recursos para el aprovechamiento del Qhapaq Ñan como parque cultural a través de una adecuada gestión cultural, y que dicho parque comprenderá 68,34 km, desde el tambo de Tambococha o Tunsucancha hasta el tambo de Taparako, por ser uno de los tramos mejor conservados e involucra importantes zonas de patrimonio cultural material e inmaterial. Conclusiones: El Camino Inca en Huánuco es uno de los patrimonios más importantes del país, y es posible ser impulsado como un parque cultural mediante un modelo de gestión cultural, si tenemos en cuenta las diversas experiencias de gestión en el país y en mundo, cuyos aportes deben servir de apoyo para un modelo de gestión en este campo.

  16. Comments on the paper 'Sorption of radionickel to goethite: effect of water quality parameters and temperature' by Hu et al

    International Nuclear Information System (INIS)

    Yuh-Shan Ho

    2011-01-01

    Recently, Hu et al. [1]. published a paper with the above title. In section 'Effect of contact time', the authors stated, 'In order to study the sorption rate constant of Ni(II) to goethite, the pseudo-second-order rate equation was used to fit the kinetic sorption of Ni(II) to goethite' and referred to two self-citations published in 2008 and 2010 respectively [2, 3]. In fact, this kinetic model has already been published first in 1996 [4], and a modified model was presented in the following years to correct a mistake in the 1996 paper [5-7]. However the mistake in the model was duplicated by other researchers [8, 9]. In order to stop the proliferation of the mistake a comment has been made [10]. This type of error could be avoided if authors have had paid more attentions to details about the model from the original paper [11]. Accuracy in citing references is very important for the transmission of scientific knowledge. Citation errors reflect poorly on authors who republish original ideas that were already published. Hopefully, the identification of this type of problems will lead to improved accuracy in referencing [12]. Authors should make serious efforts to check the accuracy of references cited in their manuscripts as well as to read the original article before quoting it rather than citing from abstracts or cross-references [13]. It is recommended that more attention should be paid in preparing bibliographies and in checking quoted references [14]. (author)

  17. Karyotypes of Akodon orophilus Osgood 1913 and Thomasomys sp. (Rodentia: Sigmodontinae from Huánuco, Peru

    Directory of Open Access Journals (Sweden)

    Víctor Pacheco

    2012-10-01

    Full Text Available Conventional chromosomal preparations were made of three native mice from Huánuco, Peru: a male and a female of Thomasomys sp., and a male of Akodon orophilus. Thomasomys sp. had a karyotype of 2n = 42, XY (n = 21, meanwhile A. orophilus presented 2n = 22, XY (n = 11. Comparisons between chromosomal pairs from the existent literature indicate that both are new karyotypes. Thomasomys sp. has a distinct sexual Y chromosome, the only metacentric (m reported for the genus. The chromosomes X and Y of A. orophilus are acrocentrics (a; and the length of chromosome Y (2/3 of the length of X distinguishes A. orophilus from other congeneric. Because the structural differences between the sexual chromosomes usually generates mechanism of reproductive isolation at intraspecific level and are bigger still in interspecific crosses, we concluded that the karyotypes reported here support the validity of the species A. orophilus and suggest that Thomasomys sp. represents a new species to science.

  18. Renal Protective Effect of Xiao-Chai-Hu-Tang on Diabetic Nephropathy of Type 1-Diabetic Mice

    Directory of Open Access Journals (Sweden)

    Chun-Ching Lin

    2012-01-01

    Full Text Available Xiao-Chai-Hu-Tang (XCHT, a traditional Chinese medicine formula consisting of seven medicinal plants, is used in the treatment of various diseases. We show here that XCHT could protect type-1 diabetic mice against diabetic nephropathy, using streptozotocin (STZ-induced diabetic mice and high-glucose (HG-exposed rat mesangial cell (RMC as models. Following 4 weeks of oral administration with XCHT, renal functions and renal hypertrophy significantly improved in the STZ-diabetic mice, while serum glucose was only moderately reduced compared to vehicle treatment. Treatment with XCHT in the STZ-diabetic mice and HG-exposed RMC resulted in a decrease in expression levels of TGF-β1, fibronectin, and collagen IV, with concomitant increase in BMP-7 expression. Data from DPPH assay, DHE stain, and CM-H2DCFDA analysis indicated that XCHT could scavenge free radicals and inhibit high-glucose-induced ROS in RMCs. Taken together, these results suggest that treatment with XCHT can improve renal functions in STZ-diabetic mice, an effect that is potentially mediated through decreasing oxidative stress and production of TGF-β1, fibronectin, and collagen IV in the kidney during development of diabetic nephropathy. XCHT, therefore merits further investigation for application to improve renal functions in diabetic disorders.

  19. Synergistic Anticancer Effects of Vorinostat and Epigallocatechin-3-Gallate against HuCC-T1 Human Cholangiocarcinoma Cells

    Directory of Open Access Journals (Sweden)

    Tae Won Kwak

    2013-01-01

    Full Text Available The aim of this study was to investigate the effect of the combination of vorinostat and epigallocatechin-3-gallate against HuCC-T1 human cholangiocarcinoma cells. A novel chemotherapy strategy is required as cholangiocarcinomas rarely respond to conventional chemotherapeutic agents. Both vorinostat and EGCG induce apoptosis and suppress invasion, migration, and angiogenesis of tumor cells. The combination of vorinostat and EGCG showed synergistic growth inhibitory effects and induced apoptosis in tumor cells. The Bax/Bcl-2 expression ratio and caspase-3 and -7 activity increased, but poly (ADP-ribose polymerase expression decreased when compared to treatment with each agent alone. Furthermore, invasion, matrix metalloproteinase (MMP expression, and migration of tumor cells decreased following treatment with the vorinostat and EGCG combination compared to those of vorinostat or EGCG alone. Tube length and junction number of human umbilical vein endothelial cells (HUVECs decreased as well as vascular endothelial growth factor expression following vorinostat and EGCG combined treatment. These results indicate that the combination of vorinostat and EGCG had a synergistic effect on inhibiting tumor cell angiogenesis potential. We suggest that the combination of vorinostat and EGCG is a novel option for cholangiocarcinoma chemotherapy.

  20. Avaliação dos óbitos ocorridos no Hospital Universitário da Universidade Federal de Santa Catarina (HU/UFSC Evaluation of deaths occurred at the University Hospital (HU/UFSC

    Directory of Open Access Journals (Sweden)

    Rachel Duarte Moritz

    2008-10-01

    Full Text Available OBJETIVO: Avaliar os óbitos ocorridos no HU/UFSC. Comparar o perfil dos pacientes que morreram nas enfermarias com o daqueles que morreram na UTI. Verificar se os óbitos foram considerados esperados (E e não evitáveis (NE. Constatar se houve recusa/suspensão de terapêutica (RST precedendo a morte. MÉTODOS: Obtivemos dados por meio de ficha elaborada pela Comissão de Óbito Hospitalar (COH, na qual constavam os aspectos demográficos, clínicos e terapêuticos dos pacientes e a avaliação da COH sobre a expectativa/evitabilidade dos óbitos. RESULTADOS: Analisamos os dados dos 326 pacientes com mais de 14 anos, que morreram entre julho/2004 e dezembro/2005. Desses, 128 morreram na UTI (G1 e 198 nas enfermarias (G2. A RST precedeu 38,2% dos óbitos no G1 e 2% no G2 (pOBJECTIVE: To evaluate the deaths which occurred at the HU/UFSC. To compare the profile of patients who died in the wards with that of patients who died in the ICU. To classify deaths which were expected or not, and avoidable or not. To verify how often withholding or withdrawing (WW therapy preceded death. METHODS: Archives of the Hospital Death Commission (HDC were analyzed. The clinical and demographic records were retrieved from the HDC data bank. Deaths were classified by the HDC as expected or not and avoidable or not. RESULTS: Data from 326 dead persons over 14 years of age were analyzed. One hundred and twenty eight deaths occurred in the ICU (G1 and 198 in the wards (G2. WW therapy preceded 38.2% of deaths in G1 and 2% in G2 (p<0.001. The main WW therapies were vasoactive drugs and antibiotics. Almost 20% of deaths were unexpected/avoidable in G1. In G2 6.5% were considered unexpected and 5% avoidable (p<0.005. Patients in G1 were younger and mostly male (p<0.005. Do-not-resuscitate orders were registered in 48.4% of patients' medical charts in G2 and 6.3% in G1 (p<0.001. Cardiopulmonary resuscitation was performed in 23.4% of patients in G1 and in 5.5% in G2 (p<0

  1. Resistance screening trials on coconut varieties to Cape Saint Paul Wilt Disease in Ghana

    Directory of Open Access Journals (Sweden)

    Quaicoe Robert Nketsia

    2009-03-01

    Full Text Available The Cape Saint Paul Wilt Disease (CSPWD is a coconut lethal yellowing type disease (LY and is the single most serious threat to coconut cultivation in Ghana. The recommended disease management strategy is the cultivation of disease-resistant coconut varieties. More than 38 varieties have been screened for their resistance to CSPWD since 1956 and the results are reviewed in this paper. Two varieties, Sri Lanka Green Dwarf (SGD and Vanuatu Tall (VTT, have shown high resistance to the disease, and their hybrid (SGD × VTT is under observation to determine its performance. A programme to rehabilitate the CSPWD-devastated areas was started in 1999. Emerging results indicate that the MYD × VTT hybrid being used for the programme, succumbs to the disease under intense disease pressure. A redirection of the rehabilitation programme and the screening of more varieties are recommended.

  2. Cataloging the world Paul Otlet and the birth of the information age

    CERN Document Server

    Wright, Alex

    2014-01-01

    The dream of capturing and organizing knowledge is as old as history. From the archives of ancient Sumeria and the Library of Alexandria to the Library of Congress and Wikipedia, humanity has wrestled with the problem of harnessing its intellectual output. The timeless quest for wisdom has been as much about information storage and retrieval as creative genius. In Cataloging the World, Alex Wright introduces us to a figure who stands out in the long line of thinkers and idealists who devoted themselves to the task. Beginning in the late nineteenth century, Paul Otlet, a librarian by training, worked at expanding the potential of the catalog card, the world's first information chip. From there followed universal libraries and museums, connecting his native Belgium to the world by means of a vast intellectual enterprise that attempted to organize and code everything ever published. Forty years before the first personal computer and fifty years before the first browser, Otlet envisioned a network of "electric t...

  3. The Courage To Be Anxious. Paul Tillich's Existential Interpretation of Anxiety

    Directory of Open Access Journals (Sweden)

    Ştefan Bolea

    2015-09-01

    Full Text Available The similitude between anxiety and death is the starting point of Paul Tillich's analysis from The Courage To Be, his famous theological and philosophical reply to Martin Heidegger's Being And Time. Not only Tillich and Heidegger are concerned with the connection between anxiety and death but also other proponents of both existentialism and nihilism like Friedrich Nietzsche, Emil Cioran and Lev Shestov. Tillich observes that "anxiety puts frightening masks" over things and perhaps this definition is its finest contribution to the spectacular phenomenology of anxiety. Moreover, Tillich has some illuminating insights about the anxiety of emptiness and meaninglessness, which are important for the history of the existential philosophy. It is interesting how the protestant theologian tries to answer to Heidegger: while the German philosopher asserted that we must avoid fear and we have to embrace anxiety as a route to personal authenticity, Tillich notes that we should transform anxiety into fear, because courage is more likely to "abolish" fear.

  4. Couplings: Agon and Composition in Paul Muldoon’s Ekphrastic Poetry

    Directory of Open Access Journals (Sweden)

    Rui Carvalho Homem

    2005-03-01

    Full Text Available In the course of more than thirty years of prolific writing, Paul Muldoon has earned a reputation for surprising his readers again and again. To a significant extent, this continued ability to “make it new” is closely linked to Muldoon’s characteristically relational writing. Often described (in tones of eulogy or of deprecation as the epitome of a postmodernist practice, his work has tested the limits of intertextuality —and his penchant for quotation, pastiche and parody has rather often sought referents in other media, notably in the visual arts. Taking a specific instance of ekphrasis in Muldoon’s poetry for its point of departure and its focus, this article proceeds to address broader themes in his work, as well as to consider his practice against the framework defined by a major alternative for reading the relationship between word and image: as rivalry and struggle, or as peaceful and mutual enablement.

  5. Richard Arwed Pfeifer - a pioneer of 'medical pedagogy' and an opponent of Paul Schroder.

    Science.gov (United States)

    Steinberg, Holger; Carius, Dirk; Himmerich, Hubertus

    2013-12-01

    Richard Arwed Pfeifer (1877-1957) was one of the initiators and foster fathers of the renowned child-psychiatric and special needs education workgroup at Leipzig University under Paul Schröder (1873-1941) in the 1920s and 1930s. This paper is an account of their dispute concerning the interrelations between child and adolescent psychiatry and special needs education, as well as their disagreement about whether adolescent psychopaths should be admitted to specialized child psychiatric wards or elsewhere. Moreover, Pfeifer questioned the practical relevance of the separation of constitutional and environmentally-based psychopathy and fought eugenic research, which he found incompatible with the ethics of his profession as a remedial teacher and child psychiatrist.

  6. Geothermic and thermal drilling in Saint-Paul-les-Dax - SPDX 1

    Energy Technology Data Exchange (ETDEWEB)

    Godard, J.M.; Tronel, F.; Penicault, J.P.; Pouchan, P.

    1994-12-31

    In 1990, the municipality of Saint Paul les Dax (Landes), located in a thermal area, has decided to promote a geothermal-balneotherapy continued project. Geological studies and seismic exploration from oil and gas allowed to decide to drill a deep well on the northern flank of Dax diapir. The drilling operation (October - December 1993) has given the following result : final depth 1665 m, thermal reservoir dated Danian-Paleocene producing water at 66 degree celsius. The potential flowrate estimated at 150 m{sup 3}/h is going to be used to met the heating requirements of public buildings, greenhouses, collective equipment and new thermal centers. The geothermal use of the water will give annual energy saving of 5 900 MWh. (Authors). 2 figs.

  7. Paul Jorion, Vers la crise du capitalisme américain

    Directory of Open Access Journals (Sweden)

    Claude Dubar

    2009-11-01

    Full Text Available Paul Jorion est un anthropologue qui s’est donné comme objet de recherche le capitalisme financier américain et sa crise. Le fait n’est pas courant : passer au cours de sa carrière de chercheur de l’étude des paludiers français et de l’apprentissage de leur métier (cf. Delbos et Jorion, La transmission des savoirs, Ed. de la MSH, 1984 à l’analyse du système financier américain suppose à la fois une grande curiosité intellectuelle et une grande flexibilité mentale. L’ouvrage dont il est ici q...

  8. Jean-Paul Marat (1743-1793, cientista e tradutor de Newton

    Directory of Open Access Journals (Sweden)

    Tosi Lucía

    1999-01-01

    Full Text Available Although Jean Paul Marat (1743-1793 is known as a political activist and as a founder of the controversial journal L'Ami du Peuple during the French Revolution, an important period of his life was spent as a medical practionner, and as a scientist. In 1765 he went to England, where he remained for eleven years mostly dedicated to medical practice and publications on that subject and on political and moral questions. Returning to France in 1776 he iniciated his researches on fire, electricity and light, that lasted practically until the French Revolution. In 1787 he published a translation of Newton's Opticks. In this article we describe in some detail his medical and scientific practice giving particular emphasis to his experiments on optics and to his theory about colors which strongly departs from newtonian theory, fully accepted by the French scientific community of the time.

  9. Paul Trapping of Radioactive 6He+ Ions and Direct Observation of Their β Decay

    International Nuclear Information System (INIS)

    Flechard, X.; Lienard, E.; Mery, A.; Rodriguez, D.; Ban, G.; Durand, D.; Duval, F.; Herbane, M.; Labalme, M.; Mauger, F.; Naviliat-Cuncic, O.; Velten, Ph.; Thomas, J. C.

    2008-01-01

    We demonstrate that abundant quantities of short-lived β unstable ions can be trapped in a novel transparent Paul trap and that their decay products can directly be detected in coincidence. Low energy 6 He + (807 ms half-life) ions were extracted from the SPIRAL source at GANIL, then decelerated, cooled, and bunched by means of the buffer gas cooling technique. More than 10 8 ions have been stored over a measuring period of six days, and about 10 5 decay coincidences between the beta particles and the 6 Li ++ recoiling ions have been recorded. The technique can be extended to other short-lived species, opening new possibilities for trap assisted decay experiments

  10. Neutron imaging options at the BOA beamline at Paul Scherrer Institut

    International Nuclear Information System (INIS)

    Morgano, M.; Peetermans, S.; Lehmann, E.H.; Panzner, T.; Filges, U.

    2014-01-01

    The BOA beamline at the Swiss spallation neutron source SINQ at Paul Scherrer Institut is a flexible instrument used mainly for testing novel techniques and devices for neutron scattering and optics, but, due to the large and relatively homogeneous field of view, it can be successfully used for experiments in the field of neutron imaging. The beamline allows also for the exploitation of advanced imaging concepts such as polarized neutron imaging and diffractive neutron imaging. In this paper we present the characterization of the BOA beamline in the light of its neutron imaging capabilities. We show also the different techniques that can be employed there as user-friendly plugins for non-standard neutron imaging experiments

  11. Epistemologi Anarkisme Paul Feyerabend dalam Studi Ilmu Tafsir al-Quran

    Directory of Open Access Journals (Sweden)

    Kurdi Fadal

    2015-03-01

    Full Text Available Tulisan ini mengkaji tentang epistemologi anarkisme Paul Feyerabend dalam studi tafsir al-Qur'an. Selama ini studi tafsir al-Qur'an telah berkembang sangat pesat sejak periode formatif, afirmatif hingga transformatif. Berbagai metode dan pendekatan telah lahir mengiringi. Perkembangan itu menunjukkan bahwa studi tafsir berjalan secara dinamis. Namun, sebagian menilai tafsir al-Qur'an telah selesai pasca generasi ketiga dalam Islam. Melalui prinsip Anything Goes yang digagas Feyerabend, metode dan pendekatan apapun yang ditawarkan untuk menafsirkan al-Qur'an dapat berjalan dan "berkontestasi" secara terbuka. Satu sisi, hal ini sangat positif bagi perkembangan ilmu tafsir dalam konteks kemajuan zaman. Namun di sisi lain, anarkisme dalam bidang ini dapat menimbulkan tafsir liar yang melahirkan problem bagi kemajuan peradaban, seperti lahirnya terorisme dalam Islam yang sering disandarkan pada ayat-ayat al-Qur'an sebagai sumber justifikasinya.

  12. Paul Karl Feyerabend: The Projections of Theoretical Proliferation in the Relation Science-Metaphysics

    Directory of Open Access Journals (Sweden)

    María Teresa Gargiulo de Vázquez

    2015-05-01

    Full Text Available The Paul Karl Feyerabend’s doctrine of theoretical proliferation has been interpreted by his experts as an attempt to preserve the ideal of scientific progress. This hermeneutics describes, in part, the intention of our philosopher. However, this reading does not explain the fundamental criticism that theoretical pluralism supposes for Feyerabend. The theoretical proliferation is itself a reductio ad absurdum of the attempts of logical positivism and critical rationalism to define science at the expense of the metaphysical. This article presents the theoretical proliferation as a vindication of the positive role that the metaphysical plays in scientific practice. We expose the Feyerabend’s defense of metaphysics inasmuch as it is constitute the possibility to overcome the conceptual conservatism, to increase empirical content of science and to recover the descriptive value of scientific theories.

  13. Paul Goma. Sabina: Social Avatars and the Vectors of creating the “New-Man”

    Directory of Open Access Journals (Sweden)

    Mariana PASINCOVSCHI

    2012-06-01

    Full Text Available Interested in building the novel based on real events and providing another version of reality, having as primary target the description of a society in which the lack of modesty is an essential feature of the “normality”, Paul Goma takes a proper route avoiding the linearity and faithfully reflecting the disorder of the evoked world. Being an agent of systematization, the narrator shows how the vectors of creating the “new-man” act: Lie, Fear, Terror, Concessions, Reeducation, Equalization and Suspendationalism, creating an autonomous and essential whole. Without having the possibility to shirk, “history is [emphasis added] the woman, with all her versatility and betrayal”, spirally expressed, in communion with the writer’s style. Therefore, in order to support the narrative pulse, feeling the writing in his fingers, the narrator combines the two “realities”, identifying the existence with the transcendence and balancing them through the dignity he demonstrates in both plans.

  14. Paul Baillon presents the book "Differential manifolds: a basic approach for experimental physicists" | 25 March

    CERN Multimedia

    CERN Library

    2014-01-01

    Tuesday 25 March 2014 at 4 p.m. in the Library, bldg. 52-1-052 "Differential manifolds: a basic approach for experimental physicists" by Paul Baillon,  World Scientific, 2013, ISBN 978-981-4449-56-4. Differential manifold is the framework of particle physics and astrophysics nowadays. It is important for all research physicists to be accustomed to it, and even experimental physicists should be able to manipulate equations and expressions in this framework. This book gives a comprehensive description of the basics of differential manifold with a full proof of elements. A large part of the book is devoted to the basic mathematical concepts, which are all necessary for the development of the differential manifold. This book is self-consistent; it starts from first principles. The mathematical framework is the set theory with its axioms and its formal logic. No special knowledge is needed. Coffee will be served from 3.30 p.m.

  15. Critical thinking in clinical nurse education: application of Paul's model of critical thinking.

    Science.gov (United States)

    Andrea Sullivan, E

    2012-11-01

    Nurse educators recognize that many nursing students have difficulty in making decisions in clinical practice. The ability to make effective, informed decisions in clinical practice requires that nursing students know and apply the processes of critical thinking. Critical thinking is a skill that develops over time and requires the conscious application of this process. There are a number of models in the nursing literature to assist students in the critical thinking process; however, these models tend to focus solely on decision making in hospital settings and are often complex to actualize. In this paper, Paul's Model of Critical Thinking is examined for its application to nursing education. I will demonstrate how the model can be used by clinical nurse educators to assist students to develop critical thinking skills in all health care settings in a way that makes critical thinking skills accessible to students. Copyright © 2012 Elsevier Ltd. All rights reserved.

  16. Testimony, Memory and Solidarity across National Borders: Paul Ricoeur and Transnational Feminism

    Directory of Open Access Journals (Sweden)

    Elizabeth Purcell

    2017-07-01

    Full Text Available In many ways, globalization created the problem of representation for feminist solidarity across the borders of the nation state. This problem is one of presenting a cohesive identity for representation in the transnational public sphere. This paper proposes a solution to this problem of a cohesive identity for women’s representation by drawing on the work of Paul Ricœur. What these women seem to have in common are shared political aims, but they have no basis for those aims. This paper provides a basis for these aims by turning to Ricœur’s work on collective memory from Memory, History, Forgetting. The paper concludes that it is the shared testimony through narrative hospitality, which can provide a foundation for a social bond for those with common political aims. More specifically, this common knowledge provides a justification for the representation of women and their allies in the transnational public sphere.

  17. Cape Saint Paul Wilt Disease of coconut in Ghana: surveillance and management of disease spread

    Directory of Open Access Journals (Sweden)

    Nkansah-Poku Joe

    2009-03-01

    Full Text Available The Cape Saint Paul Wilt Disease (CSPWD, a lethal-yellowing type disease of coconut has been in Ghana since 1932. Aerial and/or ground surveys were undertaken to assess the current status of the disease spread. The survey showed that the spread of the disease for the past 5 years has mainly been the expansion of existing foci. However, new outbreaks were identified at Glidzi in the Volta, Bawjiase and Efutu Breman in Central regions. After the resurgence in the Volta region in 1995, the Woe-Tegbi-Dzelukope corridor has remained endemic, but less aggressive. Pockets of healthy groves remain along all the coastline and inland of known disease zones. Eradication of diseased palms at Ampain focus lying just about 60 km to the Ivorian border, and disease situations on new replanting with MYD × VTT hybrid are discussed.

  18. [Paul Konitzer (1894-1947): hygienist, physician, social medicine and health politician].

    Science.gov (United States)

    Schneck, Peter

    2004-01-01

    Paul Konitzer was one of the outstanding and well-known physicians in the years after the World War II in East-Germany. THe paper describes his professional way as hygienist, social medical, municipal physician and last but not least as health politician in the times of four different political regimes: the imperial era in Germany till 1918, the time of "Weimarer Republic" till 1933, the Nazi dictatorship till 1945 and the early years in the Soviet occupation zone of Germany. The life of Konitzer is a typical example of the fate of a German doctor in the first half of the 20th century. Konitzer was arrested in February 1947 by the Soviet Military Government in Berlin in connection with some political troubles and reproach with a typhus epidemic in a German camp for Russian Prisoners of War in the Nazi era. On April 22nd 1947 he died in prison of Dresden by suicide without condemnation.

  19. Peter Paul Rubens, Nicolas-Claude Fabri de Peiresc and Joan of Arc

    Directory of Open Access Journals (Sweden)

    Borusowski Piotr

    2015-11-01

    Full Text Available In 2011 a discovery was made at the Department of Prints and Drawings of the National Museum in Warsaw - a drawing hitherto described as a Kneeling knight by an anonymous seventeenth-century artist, turned out to be Joan of Arc, a sketch well-known to art historians studying the oeuvre of Peter Paul Rubens, although thought to be lost during the Second World War. The drawing, until now known only through the black and white photograph, could be thoroughly analysed for the first time. In the context of information thus obtained, the historical context of creating the sketch transpired as an equally important matter, including the hypothetical role that may have been played in its creation by Nicolas-Claude Fabri de Peiresc.

  20. John Paul Jones: An Overlooked Autopsy Finding that May Explain His Terminal Illness.

    Science.gov (United States)

    Hamrell, Burt B

    2016-03-01

    A finding in the autopsy of John Paul Jones, the American Revolutionary War naval hero, may explain his terminal illness. During his last 2 years, he had a persistent productive cough and dyspnea. Ten days before death, he developed rapidly progressive dependent edema and ascites. He died in France in 1792. His body, preserved in alcohol in a lead coffin, was, in 1905, removed to the United States. Glomerulonephritis was noted on an autopsy, performed in France, but there was no comment then or since about ventricular wall thickness being the same in both ventricles at 5-6 mm. Hypertrophy and dilatation with biventricular failure followed by tissue shrinkage during 113 years in alcohol could have resulted in these ventricular wall findings. Systemic hypertension and left ventricular failure are consistent with his respiratory symptoms complicated perhaps by pulmonary emboli, right ventricular failure with tricuspid regurgitation, peripheral congestion, and jaundice. © 2015 American Academy of Forensic Sciences.

  1. The Curious Silence of the Dog and Paul of Tarsus; Revisiting The Argument from Silence

    Directory of Open Access Journals (Sweden)

    Michael Gary Duncan

    2012-03-01

    Full Text Available In this essay I propose an interpretative and explanatory structure for the so-called argumentum ex silento, or argument from silence (henceforth referred to as the AFS. To this end, I explore two examples, namely, Sherlock Holmes’s oft-quoted notice of the “curious incident of the dog in the night-time” from Arthur Conan Doyle’s short story “Silver Blaze,” and the historical question of Paul of Tarsus’s silence on biographical details of the historical Jesus. Through these cases, I conclude that the AFS serves as a dialogical topos best evaluated and understood through the perceived authority of the arguer and the willingness of the audience to accept that authority, due to the “curious” nature of the negative evidence that the argument employed.

  2. The ion circus: A novel circular Paul trap to resolve isobaric contamination

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez, E. Minaya [CSNSM-IN2P3/CNRS, Bat. 108, Universite de Paris Sud, 91405 Orsay (France)], E-mail: minaya@csnsm.in2p3.fr; Cabaret, S.; Lunney, D. [CSNSM-IN2P3/CNRS, Bat. 108, Universite de Paris Sud, 91405 Orsay (France)

    2008-10-15

    The ion circus is a miniature storage ring formed by a segmented radiofrequency mass filter bent into a circle. The primary goal of this unique device is to perform high-resolution mass separation with small transmission loss since the resolving power is increased while the orbiting ions cool in the ring. Contrary to its linear brother, this circular Paul trap is designed to cool and mass separate the ions over a much longer flight path, thus requiring lower buffer gas pressure. Ions can be accumulated in the ring and extracted either in tangential or perpendicular directions. This way, the trap also serves as a versatile beam distribution device. Design principles are presented and the prototype instrument, under test in Orsay, is described.

  3. A biblical death-wish: Paul celebrating dying in Phil 1:21

    Directory of Open Access Journals (Sweden)

    J. Punt

    2009-07-01

    Full Text Available Death features as an important concept in the Pauline writings in the New Testament for a number of reasons. However, the intriguing way in which the apostle at times addressed death as positive notion in itself, was traditionally related to Paul�s theological convictions and his understanding of the death of Christ in particular. The remarkably pointed way in which Paul positively celebrated death in Philippians 1:21 borders on invoking a martyrological paradigm, and raises questions about his convictions regarding life, and bodily existence in particular. Interesting analogies emerge when Paul�s celebration of death is compared in a concluding section with contemporary, popular instances where death is � even if for different reasons � presented as �gain�.

  4. Preliminary Tests of a Paul ion Trap as an Ion Source

    Science.gov (United States)

    Sadat Kiai, S. M.; Zirak, A. R.; Elahi, M.; Adlparvar, S.; Mortazavi, B. N.; Safarien, A.; Farhangi, S.; Sheibani, S.; Alhooie, S.; Khalaj, M. M. A.; Dabirzadeh, A. A.; Ruzbehani, M.; Zahedi, F.

    2010-10-01

    The paper reports on the design and construction of a Paul ion trap as an ion source by using an impact electron ionization technique. Ions are produced in the trap and confined for the specific time which is then extracted and detected by a Faraday cup. Especial electronic configurations are employed between the end caps, ring electrodes, electron gun and a negative voltage for the detector. This configuration allows a constant low level of pure ion source between the pulsed confined ion sources. The present experimental results are based on the production and confinement of Argon ions with good stability and repeatability, but in principle, the technique can be used for various Argon like ions.

  5. A world in one dimension: Linus Pauling, Francis Crick and the central dogma of molecular biology.

    Science.gov (United States)

    Strasser, Bruno J

    2006-01-01

    In 1957, Francis Crick outlined a startling vision of life in which the great diversity of forms and shapes of macromolecules was encoded in the one-dimensional sequence of nucleic acids. This paper situates Crick's new vision in the debates of the 1950s about protein synthesis and gene action. After exploring the reception of Crick's ideas, it shows how they differed radically from a different model of protein synthesis which enjoyed wide currency in that decade. In this alternative model, advocated by Linus Pauling and other luminaries, three-dimensional templates directed the folding of proteins. Even though it was always considered somewhat speculative, this theory was supported by a number of empirical results originating in different experimental systems. It was eventually replaced by a model in which the forms and shapes of macromolecules resulted solely from their amino acid sequence, dramatically simplifying the problem of protein synthesis which Crick was attempting to solve in 1957.

  6. COGNITIVE LOAD THEORY Written by John SWELLER, Paul AYRES, and Slava KALYUGA,

    Directory of Open Access Journals (Sweden)

    Reviewed by Kadir KOZAN

    2013-04-01

    Full Text Available Cognitive load theory (2011 by John Sweller, Paul Ayres, and Slava Kalyuga presents the state-of-the art form of cognitive load theory (CLT including instructional guidelines produced by the theory so far. The book achieves this in a precise, detailed and well-organized manner thereby being very informative from the very beginning to the very end. For instance, even the preface provides an ample amount of information about CLT after stating the main premise of this theory: “Without knowledge of human cognitive processes, instructional design is blind.” (p. v. As stated in the book, CLT is that sort of a theory that informs instructional design from a cognitive perspective or on the basis of how human cognition works.

  7. End of the Line? Paul Watson and the Future of the Sea Shepherd Conservation Society

    Directory of Open Access Journals (Sweden)

    Gerry Joseph Nagtzaam

    2014-03-01

    Full Text Available This paper critically examines the Sea Shepherd Conservation Society (‘SSCS’ and the legal challenges they are currently facing to continue its self-appointed role to protect oceanic life through direct action.  In Part One, the article examines the history of this radical environmental group and; the role performed by its charismatic leader Paul Watson; it’s organisational structure and its strategies and tactics; its governing philosophy and its attitudes to violence.  Part Two provides a history of the various direct actions carried out by the group; it further examines the organisation’s ongoing confrontations with the Japanese whaling fleet; documents the current legal travails the group and its leader are experiencing; and lastly asks what impact these issues will have on the group’s viability as a direct action group going forward.

  8. The poetic nature of non-religious Spirituality: A point of view by Jean Paul Sartre

    Directory of Open Access Journals (Sweden)

    Alex Villas Boas

    2014-09-01

    Full Text Available This article proposes to examine some theories of non-religious spirituality in light of the growing phenomenon of those individuals who declared themselves as having "no religion" by Brazilian religious census conducted in 2010 by the Brazilian Institute of Geography and Statistics (IBGE. The intention here is to identify how the poetic question presents itself as the fundamental element of these proposals about spirituality for authors, since beauty is part of the spiritual quest, as in: Viktor Frankl and existential religiosity grounded in the search for meaning in life; Marià Corbí and his non-religious or secular spirituality; Robert Solomon and his spirituality for skeptics, and André Comte-Sponville and his atheistic spirituality, or spirituality without God. From there, we then present the perception of spirituality in the poetry of the thought of Jean Paul Sartre, primarily in his work “what is Literature?”

  9. [Special Issue on Hmong Newcomers to Saint Paul Public Schools] Introduction

    Directory of Open Access Journals (Sweden)

    Bic Ngo

    2008-01-01

    Full Text Available In the late 1970s the aftermath of the Vietnam War brought displaced Hmong refugees (along with other Southeast Asian groups to the United States (Chan, 1994; Long, 1993. Other waves of Hmong resettlement to the United States occurred in the mid-80s and mid-90s. This has resulted in a Hmong population of 183,265, the majority of whom reside in California, Minnesota, Wisconsin, Michigan and Colorado (U.S. Census Bureau, 2005. In 2004, the Thai government closed Wat Tham Krabok (WTK, the last of its Hmong refugee camps (Grigoleit, 2006. This resulted in the most recent resettlement of approximately 15,000 Hmong refugees to the United States (Grigoleit, 2006; Hang et al., 2004. An estimated 5,000 of these WTK refugees came to St. Paul, Minnesota (Hang et al., 2004.

  10. Collision course? Donald Trump, Paul Ryan, and the fate of Medicare.

    Science.gov (United States)

    Oberlander, Jonathan

    2018-04-10

    The election of Donald Trump as president of the United States raises questions about the future of Medicare. How will Medicare fare under Republican-led government? There are several compelling reasons that the Trump administration and Congressional Republicans might avoid Medicare reform, including the political risks of taking on a popular program, the difficulties the party has encountered in trying to dismantle the Patient Protection and Affordable Care Act (ACA), the importance of older Americans to the GOP coalition, and President Trump's views about Medicare. However, because of fiscal pressures and the commitment of Speaker of the House Paul Ryan and other Republicans to entitlement reform, the GOP nonetheless could end up attempting to make major changes in Medicare. Alternatively, Republican efforts to repeal and undermine the ACA could unintentionally enhance the political fortunes of proposals to expand Medicare. Consequently, the fate of Medicare during the Trump administration remains highly uncertain.

  11. “Things are Complicated”: Paul Cornell at Marvel and DC

    Directory of Open Access Journals (Sweden)

    Martin Flanagan

    2017-12-01

    Full Text Available Paul Cornell’s work for the ‘Big Two’ U.S. comic publishers transfers a distinctly British (mostly English sensibility into a field where cues normally revolve around American cultural iconography and values. The key to his authorship is Cornell’s homespun method which, unlike 1970s and 1980s efforts of Marvel’s UK wing that transplanted American characters into a postcard-like Britain, explores a British dimension of the Marvel Universe that offers a challenge to the codes of that realm. Whether working with established heroes such as Captain Britain, twists on archetypes like Knight and Squire (English analogues of Batman and Robin, or superheroic ‘big guns’ like Wolverine, Cornell writes against tired, automatic canonicity. This paper mainly focuses on the directly British representations in the Cornell titles Captain Britain and MI-13 (2008-9 and Knight and Squire (2010.

  12. Rhetoric of Seduction and Seduction of Rhetoric in Paul de Man's ‘Allegories of Reading’

    Directory of Open Access Journals (Sweden)

    Andrea Mirabile

    2010-12-01

    Full Text Available The essay analyzes the work of Paul de Man (1919-1983, in particular Allegories of Reading. Even though his posthumously revealed ties with Nazism reduced his academic influence, de Man is still considered the leader of  Deconstruction in America, and his favorite metaphor of 'seduction' summarizes his Nietzschean theory of rhetoric as illusionism, i.e. a strategy that provoke an affective reaction, independent from logic or facts. Yet, this metaphor seems to be in contrast with other tendencies of Deconstruction, namely the self-referential, non-voluntary, autonomous status of writing, the absence of critical meta-language, the reduction of psychology in criticism.

  13. [Ilya Ilich Metchnikov and Paul Ehrlich: 1908 Nobel Prize winners for their research on immunity].

    Science.gov (United States)

    Lokaj, J; John, C

    2008-11-01

    The Nobel Prize in Physiology or Medicine in 1908 was awarded to Ilya I. Mechnikov and Paul Ehrlich for recognition of their work on immunity. Mechnikov have discovered phagocytes and phagocytosis as the basis of natural cellular immunity. His ,,phagocytic theory" is the principle of immunological concept "self and not self" as the prerequisition of physiological inflammation, and selfmaintaining of organism. Ehrlich developed the methods for standardization of antibody activity in immune sera, described neutralizing and complement-depending effect of antibodies and enunciated the ,"ide-chain" theory of the formation of antibodies. Their concept of the key-stone of immunity was different, but they expressed the basic paradigma of immunology: immunity imply the protection of identity and guarantee the integrity of organism. Both are the founders of immunology as the scientific discipline. Discoveries and conceptions of I. Mechnikov and P. Ehrlich exceedingly influenced development of immunology and are also applicable, instructive and suggestive in contemporary immunology and microbiology.

  14. Paul Ricoeur: a ética da solicitude questiona a educação

    Directory of Open Access Journals (Sweden)

    Rosa Maria Filippozzi Martini

    Full Text Available Resumo Este ensaio busca apresentar a ética da solicitude de Paul Ricoeur como um questionamento para a educação. Ricoeur buscou em sua ética distinguir a moral da ética, priorizando essa, mas colocando a moral como núcleo dela. Para o autor, trata-se de visar à vida boa com o outro em instituições justas. O autor insere a questão ética no problema da identidade narrativa de si mesmo como um outro. Ricoeur caracteriza a ética como um aceitar o outro como um si mesmo, visto que, se posso me perceber como um outro, posso também aceitar o outro como a mim mesmo. Esse movimento implica na justiça, quando referido às instituições.

  15. Valiant, Independent, and Harmonious: Paul Signac and Neo-Impressionism after 1900

    Directory of Open Access Journals (Sweden)

    Dymond, Anne

    2012-07-01

    Full Text Available Through a close reading of Parisian art criticism around 1900, this essay examines Paul Signac's role as de facto head of the neo-impressionists and guiding spirit of the Salon des Indépendants. Signac, and the neo-impressionists generally, had suffered from the decline of the Indépendants in the latter 1890s, but the resurgence of both group and Salon in 1901 positioned Signac as one of the most significant avant-garde artists in the early 20th century, where he played a vital role in the most significant art debates then animating Paris. Their return to prominence was due in no small measure to Signac's latest foray into the decorative, a highly charged arena that would be central to the artistic debates of the first decade of the 20th century.

  16. Há lugar para uma “racionalidade científica” no pensamento de Paul Feyerabend?

    OpenAIRE

    Flach, Miguel Ângelo

    2012-01-01

    A presente dissertação tem como objeto examinar se há lugar e, se houver, em que termos o seria, para uma concepção de “racionalidade científica” na obra de Paul Feyerabend. Parte-se da crítica radical que esse autor faz à racionalidade em sua visão tradicional e ao racionalismo. Para tanto, inicialmente faz-se necessário examinar a ampla concepção de “racionalismo” proposta por Feyerabend. Neste sentido, o capítulo 2 analisa o contexto da cultura grega arcaica, onde Feyerabend encontra um na...

  17. Controlling Mast Cell Activation and Homeostasis: Work Influenced by Bill Paul That Continues Today

    Directory of Open Access Journals (Sweden)

    Heather L. Caslin

    2018-04-01

    Full Text Available Mast cells are tissue resident, innate immune cells with heterogenous phenotypes tuned by cytokines and other microenvironmental stimuli. Playing a protective role in parasitic, bacterial, and viral infections, mast cells are also known for their role in the pathogenesis of allergy, asthma, and autoimmune diseases. Here, we review factors controlling mast cell activation, with a focus on receptor signaling and potential therapies for allergic disease. Specifically, we will discuss our work with FcεRI and FγR signaling, IL-4, IL-10, and TGF-β1 treatment, and Stat5. We conclude with potential therapeutics for allergic disease. Much of these efforts have been influenced by the work of Bill Paul. With many mechanistic targets for mast cell activation and different classes of therapeutics being studied, there is reason to be hopeful for continued clinical progress in this area.

  18. Controlling Mast Cell Activation and Homeostasis: Work Influenced by Bill Paul That Continues Today.

    Science.gov (United States)

    Caslin, Heather L; Kiwanuka, Kasalina N; Haque, Tamara T; Taruselli, Marcela T; MacKnight, H Patrick; Paranjape, Anuya; Ryan, John J

    2018-01-01

    Mast cells are tissue resident, innate immune cells with heterogenous phenotypes tuned by cytokines and other microenvironmental stimuli. Playing a protective role in parasitic, bacterial, and viral infections, mast cells are also known for their role in the pathogenesis of allergy, asthma, and autoimmune diseases. Here, we review factors controlling mast cell activation, with a focus on receptor signaling and potential therapies for allergic disease. Specifically, we will discuss our work with FcεRI and FγR signaling, IL-4, IL-10, and TGF-β1 treatment, and Stat5. We conclude with potential therapeutics for allergic disease. Much of these efforts have been influenced by the work of Bill Paul. With many mechanistic targets for mast cell activation and different classes of therapeutics being studied, there is reason to be hopeful for continued clinical progress in this area.

  19. Against Relativism. The Importance of Truth in the Ethics of St. John Paul II

    Directory of Open Access Journals (Sweden)

    Dorota Probucka

    2016-04-01

    Full Text Available The main aim of the paper is the analysis and critique of axiological relativism, typical of contemporary Western culture. Its supporters deny the objective status of moral norms and values. Axiological relativism leads to moral indifference based on blurring the difference between good and evil, and negating the belief that human action may be morally better or worse. I present the anti ‑relativistic position of St. John Paul II, particularly in relation to the truth, understood as a cognitive and moral value. According to the Pope, a civilization based on the belief of the relative nature of good and evil leads to widespread hypocrisy and is destined to a slow decline.

  20. [Legal regulation of the personnel issues of military medicine during the reign of Paul I].

    Science.gov (United States)

    Iskhakov, E R

    2015-08-01

    The article describes laws and regulations concerning the Russian army and navy, and accordingly its medical services accepted during the reign of Paul I. During this period different decrees aimed to improve medical personnel training in order to admit students to medical and surgical schools, reorganization of educational medical institutions, improving of professional skills of medical workers. Other decrees, aimed to improvement of recruitment of medical personnel of troops: the best students of had to be sent to troops instead physician assistant, medical staff increase and additional funding, countering the reduce of physicians' social welfare due to the inhumane attitude of the authorities, to regulate of the military medical service rotation order as well as assessment of their professional, moral, and psychological qualities.

  1. Certification of the decommissioning project for the PROTEUS research reactor at the Paul Scherrer Institute; Gutachten zum Stilllegungsprojekt der Kernanlage PROTEUS am Paul Scherrer Institut

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-12-15

    The Paul Scherrer Institute (PSI) revised the documents concerning the decommissioning of the PROTEUS research reactor. This report presents the results of the evaluation by the Swiss Federal Nuclear Safety Inspectorate (ENSI). PSI considered all relevant stipulations of nuclear energy legislation, the law on radiation protection, as well as ENSI directives. Moreover, ENSI made sure that the PROTEUS decommissioning project corresponds to the IAEA, WENRA and OECD/NEA international requirements, and corresponds to current state of science and technology. ENSI ascertained some facts that have to be looked at more deeply. Before beginning with the decommissioning work, all the fuel must be taken out of the PROTEUS facility. For each step an authorization has to be requested from ENSI with a detailed description of the work foreseen. Personal dosimetry has to be performed with calibrated dosimeters. By the use of mechanical, thermal or chemical methods to partition radioactive components, the air on the working place has to be continuously checked for radioactive aerosols. The dose limit of 0.3 mSv per year must be respected. The surveillance of the release of radioactive materials has to be done according to the PSI release regulations. By large material quantities like barite concrete blocks, graphite reflector and steel components, PSI has to describe the process used to declare the materials as inactive. For the radioactive materials expected, the containers specified have to be approved by ENSI. Before the first dismantling phase, the organization plan for all participating persons and their responsibilities have to be presented to ENSI. In its request for the decommissioning of the PROTEUS research reactor, PSI consistently demonstrates that the protection of persons and environment against radioactive radiation can be guaranteed during the dismantling of the facility and that the wastes produced can be safely managed. In consequence, all required conditions for

  2. PAUL FEYERABEND ON THE SCIENTIFIC WORLDVIEW: TOWARDS QUESTIONING THE SCIENTIFIC UNIFORMITY

    Directory of Open Access Journals (Sweden)

    N. I. Petrunok

    2014-12-01

    Full Text Available The purpose of the following article is to draw attention to main problems of scientific values as they were stated by Paul Feyerabend. Various philosophers and epistemologists have always tried to prove chosen principles and objectives, but only few dared to jeopardize their fundamentals. Stereotypes of searching for ultimate truth ceased to hold; however, scientific coordinates are still not qualified. Underlying ambiguities often remain unarticulated. Among those who ventured to shed light on them were the philosophers of post-positivistic branch. One of those who questioned science values in social, cultural, and philosophical approaches the most rigidly was Paul Feyerabend. By means of typical political concepts (such as ideology and propaganda he detected basic objectives of scientists. Our main methodological tools in this research are comparative analyses of the sources and immanent critique of Feyerabend’s arguments. The scientific novelty is based on our core objective to clarify substantial obstacles for homogeneity of science. Does such homogeneity or unity exist at any level? Feyerabend’s answer is a weak “yes”. He accepts such unity only as a useful assumption or a myth. In one of his latest books, Conquest of Abundance, he calls it a “flag” for the “people doing science.” As Feyerabend diagnosed faults of relativism, instrumentalism, and realism – all of them are threatened by the same menace of being invalid to response the world “at face value” – we have to deal somehow with topics denounced by him. In conclusion, we show important implications for the creation of a specific worldview at the intersection of philosophy and science. Considering a number of negatives, in the article we elicit fruitful ideas of Feyerabend, and contextually question them without resorting to a superficial reproach.

  3. El ilusionista de las palabras: Paul Auster y su universo creativo

    Directory of Open Access Journals (Sweden)

    Álvarez López, Esther

    2010-02-01

    Full Text Available Paul Auster is one of the greatest writers of our time. Since 1994, to his work as novelist, poet and essayist he has added scriptwriting and film directing. Both literature and cinema appear closely linked in his creative production, so that one feeds the other and vice versa, by means of themes, common characters as well as self-referential and metafictional allusions. In novels, short stories and films, Auster reveals himself, in essence, as a great storyteller. They are stories that overlap at different narrative levels following the technique of the Chinese boxes. His work is also part of a large net of internal and external references in dialogue with each other, posing and pondering on questions that have to do with identity, writing or the intersections between fiction and reality, which appear recurrently both in its literary as in its filmic form.

    Paul Auster es uno de los grandes escritores de nuestro tiempo. Desde 1994, a su labor de novelista, poeta, traductor y ensayista ha añadido la de guionista y director de cine. Ambos medios, literatura y cine, aparecen estrechamente ligados en su producción creativa, de manera que uno nutre al otro y viceversa, a través de temas y personajes comunes, de guiños autorreferenciales y metaficcionales. En novelas, relatos y películas Auster se revela, en esencia, como un gran contador de historias. Se trata de historias múltiples que se superponen a distintos niveles narrativos siguiendo la técnica de cajas chinas. Su obra forma parte de una amplia red de referencias internas y externas que dialogan entre sí, al tiempo que plantean cuestiones en torno a la identidad, la escritura o las intersecciones entre ficción y realidad, que aparecen de manera recurrente tanto en forma literaria como fílmica.

  4. [Review of the book What about me? : The struggle for identity in a market-based society, Paul Verhaeghe, 2014

    NARCIS (Netherlands)

    Nienass, Benjamin; Trautmann, Stefan

    In his book What about me? The struggle for identity in a market-based society, clinical psychologist and psychotherapist Paul Verhaeghe tries to elucidate the link between neo-liberal society, identity, and mental health. Verhaeghe starts from the observation that our identity is shaped by the

  5. 33 CFR 207.320 - Mississippi River, Twin City Locks and Dam, St. Paul and Minneapolis, Minn.; pool level.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Mississippi River, Twin City... § 207.320 Mississippi River, Twin City Locks and Dam, St. Paul and Minneapolis, Minn.; pool level. In... the Twin City Locks and Dam, Minneapolis, in the interest of navigation, and supersedes rules and...

  6. I Hear America Humming and It Is out of Tune: Review of Paul G. Woodford's "Democracy and Music Education"

    Science.gov (United States)

    Peters, Michael A.

    2008-01-01

    This article presents the author's critique on Paul G. Woodford's positions with regard to music education and the notion of liberal democracy. The author seeks to broaden the contextual/historical scholarship around John Dewey and makes it clear that liberalism is a contested concept, as is democracy. He calls for contemporary responses to…

  7. Anarchist Epistemologies and the Separation of Science and State: The Critique and Relevance of Paul Feyerabend to Educational Foundations

    Science.gov (United States)

    Wolfmeyer, Mark

    2017-01-01

    This article synthesizes Paul Feyerabend's controversial contributions to 20th-century philosophy of science through the synthesis of his works and the secondary literature, with specific foci on current trends in educational foundations and the potentials and pitfalls for applying Feyerabendian logics to our work. First, I situate his strains of…

  8. Measuring Students' Perceptions of Institutional Identity: Validating the DePaul Mission and Values Inventory at a Franciscan University

    Science.gov (United States)

    Matteo, Elizabeth K.; Bottom, Todd L.; Ferrari, Joseph R.

    2013-01-01

    The "DePaul Mission and Values Inventory" ("DMV") was validated based on the mission, identity, and values of a large, urban, Catholic, Vincentian institution. We examined the suitability of the "DMV" at a small, suburban, Catholic, Franciscan university. A sample of 275 undergraduates (218 women, 57 men:…

  9. Review Symposium; Dancing on the Ceiling: A Study of Women Managers in Education, by Valerie Hall. London: Paul Chapman, 1996.

    Science.gov (United States)

    Hall, Valerie; Gronn, Peter; Jenkin, Mazda; Power, Sally; Reynolds, Cecilia

    1999-01-01

    Hall and four colleagues review "Dancing on the Ceiling: A Study of Women Managers in Education" (Paul Chapman, 1996). Reviewers agree that Hall's profiles of six British elementary and secondary women headteachers should improve readers' understanding of female managers' development and their preference for "soft,"…

  10. Tandem Paul ja Anne Daniela Rodgers, Kaunase modernistid ja arenev Meiu Münt / Juta Kivimäe

    Index Scriptorium Estoniae

    Kivimäe, Juta, 1952-

    2006-01-01

    Kuni 23. IV Tartu Kunstimuuseumis avatud Paul ja Anne Daniela Rodgersi näitusest. 15. II-13. III Tartu kaheksas galeriis avatud Kaunase kunstnike näitusest, Arvidas Zhalpyse installatsioonist "Kõik toolist" ja Agne Jonkute maalist "Olematuse faktid" Tartu Kunstimajas. Kuni 25. III G-galeriis avatud Meiu Mündi näitusest "Päev on pime"

  11. The Economic Impact of Ten Cultural Institutions on the Economy of the Minneapolis-St. Paul SMSA.

    Science.gov (United States)

    Cwi, David

    The impact on the economy of 10 cultural institutions in the Minneapolis-St. Paul area was determined by measuring their 1978 direct and indirect fianancial effects. The institutions are the Children's Theatre Company, Chimera Theatre, Cricket Theatre, Guthrie Theatre, Minneapolis Institute of Arts, Minnesota Dance Theatre, Minnesota Orchestra,…

  12. Luxation postérieure de l'épaule chez un sujet sportif traitée par ...

    African Journals Online (AJOL)

    Luxation postérieure de l'épaule chez un sujet sportif traitée par transfert pédiculé du sub-scapulaire. Adil El Alaoui, Ilyas Rabhi, Aliou Bah, Mouhcine Sbiyaa, Amine Mezzani, Badr Alami, Amine Marzouki, Fawzi Boutayeb ...

  13. Musings on Paul Peterson's "School Politics Chicago Style" and on the Utility of Decision-Making Models.

    Science.gov (United States)

    Murphy, Jerome T.

    In "School Politics Chicago Style," Paul E. Peterson is quick to credit Graham Allison's work. There are major differences between them, however. The authors reach different conclusions about the role of rationality and bargaining because they use different definitions, because of the influence of the dominant mode of thinking at the…

  14. 76 FR 65496 - Reorganization of Foreign-Trade Zone 119 Under Alternative Site Framework, Minneapolis/St. Paul, MN

    Science.gov (United States)

    2011-10-21

    ... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [Order No. 1790] Reorganization of Foreign-Trade Zone 119 Under Alternative Site Framework, Minneapolis/St. Paul, MN Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as amended (19 U.S.C. 81a-81u), the Foreign-Trade Zones Board...

  15. Collecting, Preserving, and Interpreting the History of Electronic Games: An Interview with Jon-Paul C. Dyson

    Science.gov (United States)

    American Journal of Play, 2017

    2017-01-01

    Jon-Paul C. Dyson is vice president for exhibits and director of the International Center for the History of Electronic Games (ICHEG) at The Strong. Trained as a cultural and intellectual historian, he joined The Strong in 1998 and has worked on and supervised the development of dozens of exhibits on play and video games. He initiated the museum's…

  16. 75 FR 5452 - Regulations Under the Paul Wellstone and Pete Domenici Mental Health Parity and Addiction Equity...

    Science.gov (United States)

    2010-02-02

    ... Regulations Under the Paul Wellstone and Pete Domenici Mental Health Parity and Addiction Equity Act of 2008... and Pete Domenici Mental Health Parity and Addiction Equity Act of 2008 (MHPAEA). MHPAEA prohibits... collection techniques or other forms of information technology; and Estimates of capital or start-up costs...

  17. La Justice et la Vengeance divine poursuivant le Crime. Pierre-Paul Prud’hon a emblematická tradice

    Czech Academy of Sciences Publication Activity Database

    Konečný, Lubomír

    2014-01-01

    Roč. 63, 1/2 (2014), s. 86-93 ISSN 1211-7390 Institutional support: RVO:68378033 Keywords : Pierre-Paul Prud’hon * Nicolas Frochot * Marin Le Roy de Gomberville * Otto van Veen Subject RIV: AL - Art, Architecture, Cultural Heritage

  18. Aryl hydrocarbon receptor-dependent retention of nuclear HuR suppresses cigarette smoke-induced cyclooxygenase-2 expression independent of DNA-binding.

    Science.gov (United States)

    Zago, Michela; Sheridan, Jared A; Nair, Parameswaran; Rico de Souza, Angela; Gallouzi, Imed-Eddine; Rousseau, Simon; Di Marco, Sergio; Hamid, Qutayba; Eidelman, David H; Baglole, Carolyn J

    2013-01-01

    The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that responds to man-made environmental toxicants, has emerged as an endogenous regulator of cyclooxygenase-2 (Cox-2) by a mechanism that is poorly understood. In this study, we first used AhR-deficient (AhR(-/-) ) primary pulmonary cells, together with pharmacological tools to inhibit new RNA synthesis, to show that the AhR is a prominent factor in the destabilization of Cox-2 mRNA. The destabilization of Cox-2 mRNA and subsequent suppression of cigarette smoke-induced COX-2 protein expression by the AhR was independent of its ability to bind the dioxin response element (DRE), thereby differentiating the DRE-driven toxicological AhR pathway from its anti-inflammatory abilities. We further describe that the AhR destabilizes Cox-2 mRNA by sequestering HuR within the nucleus. The role of HuR in AhR stabilization of Cox-2 mRNA was confirmed by knockdown of HuR, which resulted in rapid Cox-2 mRNA degradation. Finally, in the lungs of AhR(-/-) mice exposed to cigarette smoke, there was little Cox-2 mRNA despite robust COX-2 protein expression, a finding that correlates with almost exclusive cytoplasmic HuR within the lungs of AhR(-/-) mice. Therefore, we propose that the AhR plays an important role in suppressing the expression of inflammatory proteins, a function that extends beyond the ability of the AhR to respond to man-made toxicants. These findings open the possibility that a DRE-independent AhR pathway may be exploited therapeutically as an anti-inflammatory target.

  19. A comparative study of oral health attitudes and behavior using the Hiroshima University-Dental Behavioral Inventory (HU-DBI) between dental and civil engineering students in Colombia.

    Science.gov (United States)

    Jaramillo, Jorge A; Jaramillo, Fredy; Kador, Itzjak; Masuoka, David; Tong, Liyue; Ahn, Chul; Komabayashi, Takashi

    2013-03-01

    The aim of this study was to use the Hiroshima University - Dental Behavioral Inventory (HU-DBI) to compare oral health attitudes and behavior of dental and civil engineering students in Colombia. The HU-DBI's survey consisting of twenty dichotomous responses (agree-disagree) regarding tooth brushing, was completed at University Antonio Narino for the dental students and the University of Cauca for the civil engineering students. The Spanish version of the HU-DBI questionnaire was taken by 182 of 247 dental students and 411 of 762 engineering students. The data was-statistically analyzed by the chi-square test and backward logistic regression. Compared to the engineering students, the dental students were more likely to agree with questions such as "I am bothered by the color of my gums"(OR = 2.2, 95% CI: 1.3-3.7),"I think I can clean my teeth well without using toothpaste" (OR = 3.0, 95% CI: 1.5-5.9), "I have used a dye to see how clean my teeth are" (OR = 2.9, 95% CI: 1.9-4.3), and "I have had my dentist tell me that I brush very well" (OR = 2.0, 95% CI: 1.3-3.1). The dental education curriculum in a dental school compared to a civil engineering school in Colombia indicated that a three-phase curriculum in didactics and clinics increased oral health attitudes and behavior from entry to graduation.

  20. HU participates in expression of a specific set of genes required for growth and survival at acidic pH in Escherichia coli.

    Science.gov (United States)

    Bi, Hongkai; Sun, Lianle; Fukamachi, Toshihiko; Saito, Hiromi; Kobayashi, Hiroshi

    2009-05-01

    The major histone-like Escherichia coli protein, HU, is composed of alpha and beta subunits respectively encoded by hupA and hupB in Escherichia coli. A mutant deficient in both hupA and hupB grew at a slightly slower rate than the wild type at pH 7.5. Growth of the mutant diminished with a decrease in pH, and no growth was observed at pH 4.6. Mutants of either hupA or hupB grew at all pH levels tested. The arginine-dependent survival at pH 2.5 was diminished approximately 60-fold by the deletion of both hupA and hupB, whereas the survival was slightly affected by the deletion of either hupA or hupB. The mRNA levels of adiA and adiC, which respectively encode arginine decarboxylase and arginine/agmatine antiporter, were low in the mutant deficient in both hupA and hupB. The deletion of both hupA and hupB had little effect on survival at pH 2.5 in the presence of glutamate or lysine, and expression of the genes for glutamate and lysine decarboxylases was not impaired by the deletion of the HU genes. These results suggest that HU regulates expression of the specific set of genes required for growth and survival in acidic environments.