WorldWideScience

Sample records for shih jen min

  1. Use of Shih in Chinese Operational Art

    Science.gov (United States)

    2016-05-26

    These include leaders seeking to manipulate context, build troop morale through context, use an indirect approach, and exploit propensity within a...characteristics help determine whether or not shih was a factor in a given conflict. These include leaders seeking to manipulate context, build troop morale ...U.S. Army War College, 2011), ix-x; William H. Mott and Jae Chang Kim, The Philosophy of Chinese Military Culture: Shih vs. Li (New York, NY: Palgrave

  2. PanJen

    DEFF Research Database (Denmark)

    Jensen, Cathrine Ulla; Panduro, Toke Emil

    functional transformations, driven by an a priori and theory-based hypothesis. The plots and model fit metrics enable users to make an informed choice of how to specify the functional form the regression. We show that the PanJen ranking outperforms the Box-Tidwell transformation, especially in the presence...... of inefficiency, heteroscedasticity or endogeneity....

  3. Annual report on JEN-1 and JEN-2 Reactors

    International Nuclear Information System (INIS)

    Montes Ponce de Leon, J.

    1974-01-01

    In the annual report on the JEN-1 and JEN-2 reactors the main fractures of the reactor operations and maintenance are described. The reactor has been in operation for 2188 hours, what means 74% of the total working time. Maintenance and periodical tests have occupied the rest of the time. Maintenance operations are shown according to three main subjects, the main failures so as the reactor scrams are also described. Different date relating with radiation level and health Physics are also included. (Author)

  4. Jens Beckert, 2016, Fraud and Fantasy

    DEFF Research Database (Denmark)

    Harrington, Brooke

    2017-01-01

    Contribution to review symposium on: Jens Beckert (2016): Imagined Futures. Fictional Expectations and Capitalist Dynamics. Harvard University Press. Other ontributions from: Akos Rona-Tas (University of California, San Diego) ; William Deringer (Massachusetts Institute of Technology) and Jenny...

  5. A case of gastrinoma in a Shih-Tzu dog.

    Science.gov (United States)

    Fukushima, Ushio; Sato, Miyuki; Okano, Shozo; Aramaki, Yoshitaka; Ito, Hiroshi; Yoshioka, Kazuki; Oyamada, Toshifumi; Uechi, Masami

    2004-03-01

    A five-year-old male Shih-Tzu dog presented with severe vomiting and weight loss. The clinical signs were successfully improved by an eight-day treatment with an H(2)-receptor antagonist, gastrointestinal protectant and antibiotics. Ten days later, however, recurrence of vomiting was seen despite continuous medical treatment. Based on clinical signs and the results of various diagnostic tests including CBC, biochemical analysis, contrast radiography, and endoscopy, a duodenal or pancreatic neoplasm was suspected and exploratory laparotomy was conducted. Some swollen pancreatic regions were found, and biopsy of the pancreas indicated the diagnosis of a gastrin-secreting tumor. Consequently, based on a high serum gastrin level as well as clinical signs and immunohistological findings, we diagnosed the disease as canine gastrinoma, a rare tumor of the pancreas.

  6. Annual report on JEN-1 and JEN-2 Reactors; Informe periodico de Reactores JEN-1 y JEN-2 correpondiente al ano 1972

    Energy Technology Data Exchange (ETDEWEB)

    Montes Ponce de Leon, J.

    1974-07-01

    In the annual report on the JEN-1 and JEN-2 reactors the main fractures of the reactor operations and maintenance are described. The reactor has been in operation for 2188 hours, what means 74% of the total working time. Maintenance and periodical tests have occupied the rest of the time. Maintenance operations are shown according to three main subjects, the main failures so as the reactor scrams are also described. Different date relating with radiation level and health Physics are also included. (Author)

  7. Jens Haug keelab oma lastel majandust õppida / Piret Reiljan

    Index Scriptorium Estoniae

    Reiljan, Piret, 1983-

    2006-01-01

    Endine ärimees Jens Haug õpib ülikoolis semiootikat ja töötab majandus- ja kommunikatsiooniministeeriumis kriisireguleerimise osakonnas. Vt. samas: Kolleeg hindab Jens Haugi teravat mõistust; Karjäär

  8. Determination flux in the Reactor JEN-1

    International Nuclear Information System (INIS)

    Manas Diaz, L.; Montes Ponce de leon, J.

    1960-01-01

    This report summarized several irradiations that have been made to determine the neutron flux distributions in the core of the JEN-1 reactor. Gold foils of 380 μ gr and Mn-Ni (12% de Ni) of 30 mg have been employed. the epithermal flux has been determined by mean of the Cd radio. The resonance integral values given by Macklin and Pomerance have been used. (Author) 9 refs

  9. Ivor Jennings's Constitutional Legacy beyond the Occidental-Oriental Divide

    OpenAIRE

    Malagodi, M.

    2015-01-01

    Sir W. Ivor Jennings (1903–1965) was one of Britain's most prominent constitutional law scholars of the twentieth century. He is mostly famed for his work in the 1930s on English Public Law. In 1941, Jennings, however, moved to Sri Lanka, progressively becoming involved in both an academic and professional capacity with constitutional processes across the decolonizing world in the early stages of the Cold War. This article provides an alternative account of Jennings's constitutional legacy to...

  10. Annual report on JEN-1 reactor

    International Nuclear Information System (INIS)

    Montes, J.

    1972-01-01

    In the annual report on the JEN-1 reactor the main features of the reactor operations and maintenance are described. The reactor has been critical for 1831 hours, what means 65,8% of the total working time. Maintenance and pool water contamination have occupied the rest of the time. The maintenance schedule is shown in detail according to three subjects. The main failures and reactor scrams are also described. The daily maximum values of the water activity are given so as the activity of the air in the reactor hall. (Author)

  11. Core optimization studies at JEN-Spain

    International Nuclear Information System (INIS)

    Gomez Alonso, M.

    1983-01-01

    The JEN-1 is a 3-MW reactor which uses flat-plate fuel elements. It was originally fueled with 20%-enriched uranium but more recently with 90%-enriched fuel. It now appears that it will have to be converted back to using 20%- enriched fuel. Progress is presently being made in fuel fabrication. Plates with meat thicknesses of up to 1.5 mm have been fabricated. Plates are being tested with 40 wt % uranium in the fuel meat. Progress is also being made in reactor design in collaboration with atomic energy commissions of other countries for swimming pool reactors being designed or under construction in Chile, Ecuador, and Spain itself. The design studies address core optimization, safety analysis report updating, irradiation facilities, etc. Core optimization is specifically addressed in this paper. A common swimming-pool-type reactor such as the JEN-1 served as an example. The philosophy adopted in this study is not to try to match the high enrichment core, but rather to treat the design as new and try to optimize it using simplified neutronic/thermal hydraulic/economic models. This philosophy appears to be somewhat original. As many as possible of the fuel parameters are constrained to remain constant

  12. Translations of JEN-MIN JIH-PAO Articles on Sociological and Economic Subjects

    Science.gov (United States)

    1960-06-23

    atmosphere filled, with fiery enthusiasm and the spirit of realism . kchie ver/ients At fcributabie_to_Poli^ios^SBjirning Taking for example the...but also gradually achieved good -quality. The stage play is different from the cinematic film. At the beginning of its performance, there might...forward the combination of revolutionary realism with revolutionary romaticism, &t-<x this is a creative method’which is in keeping with the spirt

  13. Annual report on JEN-1 reactor; Informe periodico del Reactor JEN-1 correspondiente al ano 1971

    Energy Technology Data Exchange (ETDEWEB)

    Montes, J

    1972-07-01

    In the annual report on the JEN-1 reactor the main features of the reactor operations and maintenance are described. The reactor has been critical for 1831 hours, what means 65,8% of the total working time. Maintenance and pool water contamination have occupied the rest of the time. The maintenance schedule is shown in detail according to three subjects. The main failures and reactor scrams are also described. The daily maximum values of the water activity are given so as the activity of the air in the reactor hall. (Author)

  14. Towards a New Confessionalism: Elizabeth Jennings and Sylvia Plath

    OpenAIRE

    Dowson, Jane

    2011-01-01

    Due to their self-disclosing manner, both Elizabeth Jennings (1926-2001) and Sylvia Plath (1932-63) have been labelled ‘confessional’ yet have markedly different life experiences and profiles in literary and popular imaginations. Jennings was born in Boston, Lincolnshire, and educated in Oxford where she lived for the rest of her life. She had a broken engagement then a relationship with a married man but never married or had children. Plath emigrated to Cambridge University from America in 1...

  15. Outrunning Asthma: Football Player Rashad Jennings Battled Childhood Asthma with Exercise and Determination

    Science.gov (United States)

    ... us Outrunning Asthma Football player Rashad Jennings battled childhood asthma with exercise and determination Photo: ABC National Football ... Dancing with the Stars” champion Rashad Jennings battled childhood asthma with grit and determination. He has partnered with ...

  16. Recurring themes in the legacy of Jens Rasmussen

    DEFF Research Database (Denmark)

    Waterson, Patrick; Le Coze, Jean-Christophe; Andersen, Henning Boje

    2016-01-01

    The work of Jens Rasmussen over the course of the last half century represents some of the most influential contributions to the fields of cognitive science, human factors, ergonomics and safety science. His work has inspired researchers and practitioners in a number of fields including psycholog...

  17. Calming effect of orally administered γ-aminobutyric acid in Shih Tzu dogs.

    Science.gov (United States)

    Uetake, Katsuji; Okumoto, Ayano; Tani, Noriko; Goto, Akihiro; Tanaka, Toshio

    2012-12-01

    The calming effects of γ-aminobutyric acid (GABA) by oral administration were investigated in four adult Shih Tzu dogs. Three dosage levels (1, 2 and 4 mg/kg body weight) and non-administration were tested by an increase and decrease method. Changes in activity (for 1.5 h) and urinary cortisol levels (pre-administration, 3 and 7 h later) of dogs were monitored after administration. Without reference to dosage level, the mean times spent standing (P = 0.06), sitting (P level was observed at 7 h after administration (P GABA exerts calming effects on dogs as well as humans. © 2012 The Authors. Animal Science Journal © 2012 Japanese Society of Animal Science.

  18. Double Intussusception in a Shih-Tzu Puppy: The Triple-Circle Sign

    Directory of Open Access Journals (Sweden)

    J. M. Kim, S. S. Kang1, G. Kim and S. H. Choi*

    2012-05-01

    Full Text Available Intussusception is a common surgical disorder in puppies. Double intussusception (DI however, is an extremely rare form of this pathology. The authors report a case of a 3-month-old, Shih-Tzu puppy referred to Veterinary Medical Center of Chungbuk National University, Korea with symptoms of abdominal discomfort, intermittent vomiting and bloody diarrhea for 5 days. Ultrasonographic examination of the left mid-abdominal region revealed a mass with a ‘triple case’ sign completely different from the classic ‘target sign’. The surgical intervention confirmed it to be an ileocecal DI in ascending colon. The case emphasizes the rare ‘triple case’ sign as a descriptive finding on ultrasonography in DI presentations.

  19. OnlineMin

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Moruz, Gabriel; Negoescu, Andrei

    2015-01-01

    OnlineMin that has optimal competitiveness and allows fast implementations. In fact, if k pages fit in internal memory the best previous solution required O(k2) time per request and O(k) space. We present two implementations of OnlineMin which use O(k) space, but only O(logk) worst case time and O...

  20. A Case Study of Synchronous Distance Learning Between Shih Chien University and Beijing Foreign Studies University

    Directory of Open Access Journals (Sweden)

    Yen-Fen Lo

    2016-08-01

    Full Text Available Shih Chien University and Beijing Foreign Studies University collaboratively launched a project to offer synchronous distance learning courses on "Case Studies of Taiwanese Entrepreneurs" since February 2012. The three objectives of this study are: (1 to explore the Cross-Strait students' motives for selecting the course; (2 to examine the students' accommodation condition before and after completing the course; (3 to discuss the student's level of satisfaction of the course. This study uses qualitative data from case study interviews conducted in the second year of the project based on the research focus of the Cross-Strait students' motivation and satisfaction of the course. The research analysis tools are content analysis and theory triangulation. The findings are: (1 Cross-Strait students are motivated by their curiosity about the course, interest in the contents, and willingness to experience the novelty of distance learning to select the course; (2 the results of Cross-Strait students' accommodation condition are correlated to their interactions with the professor, the familiarity with the materials, the quality of the communication equipment, and the clarity of the images; (3 Cross-Strait students all accept the method of synchronous distance learning; (4 the quality of communication equipment has the lowest level of satisfaction.

  1. Determination flux in the Reactor JEN-1; Medida de flujos de neutrones en el nucleo del Reactor JEN-1

    Energy Technology Data Exchange (ETDEWEB)

    Manas Diaz, L; Montes Ponce de leon, J.

    1960-07-01

    This report summarized several irradiations that have been made to determine the neutron flux distributions in the core of the JEN-1 reactor. Gold foils of 380 {mu} gr and Mn-Ni (12% de Ni) of 30 mg have been employed. the epithermal flux has been determined by mean of the Cd radio. The resonance integral values given by Macklin and Pomerance have been used. (Author) 9 refs.

  2. Factors Associated with Fear of Falling among Community-Dwelling Older Adults in the Shih-Pai Study in Taiwan

    OpenAIRE

    Chang, Hsiao-Ting; Chen, Hsi-Chung; Chou, Pesus

    2016-01-01

    Background Fear of falling is an important risk indicator for adverse health related outcomes in older adults. However, factors associated with fear of falling among community-dwelling older adults are not well-explored. Objectives To explore the quality of life and associated factors in fear of falling among older people in the Shih-Pai area in Taiwan. Methods This community-based survey recruited three thousand eight hundred and twenty-four older adults aged ? 65 years. The measurements inc...

  3. Afsluttende kommentar til Jens Ravnkildes tre artikler om retskildebegrebet

    DEFF Research Database (Denmark)

    Holtermann, Jakob v. H.; Olsen, Henrik Palmer

    2014-01-01

    I dette andet svar til Dr. Jur. Jens Ravnkildes fortsatte forsvar for sit tidligere fremsatte forslag til et retskildebegreb klargør og udbygger lektor Jakob v. H. Holtermann og professor Henrik Palmer Olsen deres kritik yderligere. I den forbindelse afviser de også Ravnkildes ganske sensationell...... påstand om, at Ross blot fem år før sin død i 1979 helt skulle have forladt sit livsværk og opgivet sin karakteristiske version af retsrealismen til fordel for traditionel kelseniansk retspositivisme...

  4. Thermal and hydraulic characteristics of the JEN-1 Reactor; Caracteristicas hidraulicas y termicas del Reactor JEN-1

    Energy Technology Data Exchange (ETDEWEB)

    Otra Otra, F; Leira Rey, G

    1971-07-01

    In this report an analysis is made of the thermal and hydraulic performances of the JEN-1 reactor operating steadily at 3 Mw of thermal power. The analysis is made separately for the core, main heat exchanger and cooling tower. A portion of the report is devoted to predict the performances of these three main components when and if the reactor was going to operate at a power higher than the maximum 3 Mw attainable today. Finally an study is made of the unsteady operation of the reactor, focusing the attention towards the pumping characteristics and the temperatures obtained in the fuel elements. Reference is made to several digital calculation programmes that nave been developed for such purpose. (Author) 21 refs.

  5. A distilled fire of thirteen hells – Jens Baggesen between the Germans and the Danes

    DEFF Research Database (Denmark)

    Blicher, Henrik

    Venskabet mellem Carl Friedrich Cramer og Jens Baggesen blev et politisk anliggende for første gang under den såkaldte Tyskerfejde i 1789, da latente spændinger mellem en indflydelsesrig tysk gruppering i København en og en større nationalt orienteret gruppe borgere blev til åben konflikt. Jens B...... tyske aristokrati i København. Det prekære forhold har sat sig indirekte, men tydelige spor i rejseskildringen Labyrinten (bd. 1-2, 1792-93), der på denne baggrund fremstår som en apologi for Jens Baggesens position....

  6. Information from Yüan Shih on the Military Cooperation between the Golden Horde and the Yüan Dynasty.

    Directory of Open Access Journals (Sweden)

    Zhu-Cheng Zhao.

    2016-12-01

    Full Text Available Research objective: to reveal relations in military affairs between the Golden Horde and the Yüan Dynasty on the basis of the data of the Chinese dynastic history Yüan shih. Research materials: because of the large distance between these medieval Chinggisid powers, internecine strife between the houses of the Jochids and Toluids, armed conflicts between Arik-Boke and Kublai and due to the fact that the rulers of the Jochid ulus supported Arik-Boke, their state became independent from the Great Mongol Empire. Later on, long-term military conflicts and political turmoil interrupted communication between Sarai and Khanbalik. The Jochid ulus and the Yuan dynasty conducted their own foreign policies. However, communication between them was not interrupted and some information from the Golden Horde still fall in Chinese chronicles. One of the important and fundamental sources relating to the Mongol history is Yüan shih (History of the Yüan Dynasty. This written source contains some materials (although in fragments revealing the nature of the relations between the Yuan Dynasty and the Golden Horde. Research results and novelty: the author has provided information that the military units composed of the peoples of the Golden Horde (primarily of the Ases and Kipchaks, as well as of the Russians were among the troops in the Yüan Empire. At the same time, their proportion was significant both in the composition of commanding staff, as well as among ordinary soldiers. However, the source does not contain any information about the conditions under which these warriors arrived in China as well as about the routes they were moving. It is indisputable fact that they were sent to the Far East from the Jochid ulus during the highest power of this state in the reign of khan Uzbek. Perhaps it was an indication that the Yüan emperor displayed his authority over Sarai Khan in the political sense as well.

  7. Jens Glad Balchen: A Norwegian Pioneer in Engineering Cybernetics

    Directory of Open Access Journals (Sweden)

    Morten Breivik

    2009-07-01

    Full Text Available This paper tells the story of Jens Glad Balchen (1926-2009, a Norwegian research scientist and engineer who is widely regarded as the father of Engineering Cybernetics in Norway. In 1954, he founded what would later become the Department of Automatic Control at the Norwegian Institute of Technology in Trondheim. This name was changed to the Department of Engineering Cybernetics in 1972 to reflect the broader efforts being made, not only within the purely technical disciplines, but also within biology, oceanography and medicine. Balchen established an advanced research community in cybernetics in postwar Norway, whose applications span everything from the process industry and positioning of ships to control of fish and lobster farming. He was a chief among the tribe of Norwegian cybernetics engineers and made a strong impact on his colleagues worldwide. He planted the seeds of a whole generation of Norwegian industrial companies through his efforts of seeking applications for every scientific breakthrough. His strength and his wisdom in combination with his remarkable stubbornness gave extraordinary results.

  8. Instant MinGW starter

    CERN Document Server

    Shpigor, Ilya

    2013-01-01

    This is a Starter guide designed to enable the reader to start using MinGW to develop Microsoft Windows applications as quickly, and as efficiently, as possible. This book is for C and C++ developers who are looking for new and effective instruments to use in application development for Microsoft Windows. No experience of MinGW is needed: this book will guide you through the essentials to get you using the software like a pro in a matter of hours.

  9. EpiJen: a server for multistep T cell epitope prediction

    Directory of Open Access Journals (Sweden)

    Guan Pingping

    2006-03-01

    Full Text Available Abstract Background The main processing pathway for MHC class I ligands involves degradation of proteins by the proteasome, followed by transport of products by the transporter associated with antigen processing (TAP to the endoplasmic reticulum (ER, where peptides are bound by MHC class I molecules, and then presented on the cell surface by MHCs. The whole process is modeled here using an integrated approach, which we call EpiJen. EpiJen is based on quantitative matrices, derived by the additive method, and applied successively to select epitopes. EpiJen is available free online. Results To identify epitopes, a source protein is passed through four steps: proteasome cleavage, TAP transport, MHC binding and epitope selection. At each stage, different proportions of non-epitopes are eliminated. The final set of peptides represents no more than 5% of the whole protein sequence and will contain 85% of the true epitopes, as indicated by external validation. Compared to other integrated methods (NetCTL, WAPP and SMM, EpiJen performs best, predicting 61 of the 99 HIV epitopes used in this study. Conclusion EpiJen is a reliable multi-step algorithm for T cell epitope prediction, which belongs to the next generation of in silico T cell epitope identification methods. These methods aim to reduce subsequent experimental work by improving the success rate of epitope prediction.

  10. PREFACE: Festschrift to mark the sixtieth birthday of Professor Jens Lothe

    Science.gov (United States)

    Jøssang, Torstein; Barnett, David M.

    1992-01-01

    The collection of papers in this Festschrift represents the proceedings of a symposium held at the Norwegian Academy of Science and Letters on November 25-26, 1991, marking the occasion of the sixtieth birthday of Professor Jens Lothe. The symposium organizers attempted to invite contributors, either written, oral, or both, from a group of international scientists who have either collaborated with Jens in the past or whose work has had a significant impact in one of three areas in which Jens has focussed his own research interests, namely, statistical physics, elasticity and elastic waves, and the theory of dislocations in crystalline solids. The extent to which we have succeeded in obtaining a proper spectrum of contributors and contributions must be judged by the readers of this volume. It is rather rare in modern times to encounter a physicist such as Jens who has made seminal contributions in fields as diverse as the three included in this Festschrift. For this reason it is both historically interesting and instructive to follow the path that Jens Lothe's research career has taken him, since doing so clearly points out the international nature of the scientific endeavor and the fact that the search for scientific truth transcends national borders and governmental ideologies. Jens' postdoctoral studies at the University of Bristol in the late 1950s brought him in contact with an American postdoctoral student, John Hirth, who had worked on nucleation theory and condensation under the late Professor G M Pound at Carnegie-Mellon University. (Alex Maradudin, one of the contributors to the surface wave session of this symposium was also a postdoctoral fellow at Bristol at this time.) Both Lothe and Hirth had come to Bristol to acquaint themselves with dislocation theory; their first joint paper on double-kink nucleation theory was followed by numerous joint efforts, including their now-classic book Theory of Dislocations. Clearly, their interaction jelled. As legend

  11. 13-16-vuotiaiden tyypin 1 diabetesta sairastavien tyttöjen liikuntatottumukset

    OpenAIRE

    Vainionpää, Milja; Mykkänen, Janika

    2016-01-01

    Opinnäytetyön tavoitteena oli tuottaa tietoa terveydenhuollon ammattihenkilöille 13–16-vuotiaiden tyypin 1 diabetesta sairastavien tyttöjen liikuntatottumuksista ja liikunnan harrastamisesta. Opinnäytetyön tarkoituksena oli kuvailla 13–16-vuotiaiden tyypin 1 diabetesta sairastavien tyttöjen liikuntatottumuksia sekä selvittää, mitkä tekijät edistävät tai hankaloittavat liikunnan harrastamista. Tutkimuskysymyksiä olivat: 1. Minkälaisia ovat 13–16-vuotiaiden tyypin 1 diabetesta sairastavi...

  12. An Investigation of the Painting Technique in Portraits by Jens Juel

    DEFF Research Database (Denmark)

    Slotsgaard, Tine Louise

    2014-01-01

    This paper summarizes the findings of the first technical art historical study executed on paintings by the Danish portrait painter Jens Juel. Eight portrait paintings on canvas from two different time periods in the career of Jens Juel have been examined and compared in order to establish the use...... of materials, working methods and painting techniques, and whether an artistic development can be traced. The findings include the characteristics of the canvas structure and painting grounds, how the canvas was prepared and the artist’s use of underdrawing, as well as the layered build up of the carnation...

  13. Factors Associated with Fear of Falling among Community-Dwelling Older Adults in the Shih-Pai Study in Taiwan.

    Directory of Open Access Journals (Sweden)

    Hsiao-Ting Chang

    Full Text Available Fear of falling is an important risk indicator for adverse health related outcomes in older adults. However, factors associated with fear of falling among community-dwelling older adults are not well-explored.To explore the quality of life and associated factors in fear of falling among older people in the Shih-Pai area in Taiwan.This community-based survey recruited three thousand eight hundred and twenty-four older adults aged ≥ 65 years. The measurements included a structured questionnaire, including quality of life by using Short-Form 36, and information of fear of falling, fall history, demographics, medical conditions, insomnia, sleep quality, depression and subjective health through face-to-face interviews.A total of 53.4% of participants reported a fear of falling. The rate of fear of falling was higher in female subjects. Subjects with fear of falling had lower Short Form-36 scores both for men and women. Falls in the previous year, older age, insomnia, depression and worse subjective health were correlates of fear of falling for both sexes. Male-specific associations with fear of falling were the accessibility of medical help in an emergency, diabetes mellitus and stroke. In parallel, cardiovascular diseases were a female-specific correlate for fear of falling.Fear of falling is prevalent among community-dwelling older adults. It is seems that there are gender differences in fear of falling with respect to the prevalence and associated factors in older adults. Gender differences should be considered when planning prevention and intervention strategies for fear of falling among older people.

  14. [Jennings Randolph Forum (3rd, Washington, District of Columbia, May 20-22, 1984).

    Science.gov (United States)

    CAC Citizenship Education News, 1984

    1984-01-01

    This overview of the third annual Jennings Randolph Forum focuses on the role that election campaigns and the political process are capable of playing in citizenship education. Council for the Advancement of Citizenship (CAC) testimony on citizenship education follows a general overview of the conference proceedings. A set of mandates for…

  15. Co-ordinate regulation of lactate metabolism genes in yeast: the role of the lactate permease gene JEN1.

    Science.gov (United States)

    Lodi, T; Fontanesi, F; Guiard, B

    2002-01-01

    In the yeast Saccharomyces cerevisiae, the first step in lactate metabolism is its transport across the plasma membrane, a proton symport process mediated by the product of the gene JEN1. Under aerobic conditions, the expression of JEN1 is regulated by the carbon source: the gene is repressed by glucose and induced by non-fermentable substrates. JEN1 expression is also controlled by oxygen availability, but is unaffected by the absence of haem biosynthesis. JEN1 is negatively regulated by the repressors Mig1p and Mig2p, and requires Cat8p for full derepression. In this report we demonstrate that, in addition to these regulators, the Hap2/3/4/5 complex interacts specifically with a CAAT-box element in the JEN1 promoter, and acts to derepress JEN1 expression. We also provide evidence for transcriptional stimulation of JEN1 by the protein kinase Snf1p. Data are presented which provide a better understanding of the molecular mechanisms implicated in the co-regulation of genes involved in the metabolism of lactate.

  16. Eesti esinumber Jens Salumäe : mul hakkas töötahe kaduma / Deivil Tserp

    Index Scriptorium Estoniae

    Tserp, Deivil, 1968-

    2007-01-01

    Eesti Suusaliidu juhid lähtusid suusahüppaja Jens Salumäe soovist ja kutsusid koondise peatreeneriks tema soomlasest abilise Sami Leskineni. Kommenteerib suusahüppekoondise peatreeneri kohalt taandunud Hillar Hein

  17. Calculations of Changes in Reactivity during some regular periods of operation of JEN-1 MOD Reactor

    International Nuclear Information System (INIS)

    Alcala Ruiz, F.

    1973-01-01

    By a Point-Reactor model and Perturbation Theory, changes in reactivity during some regular operating periods of JEN-1 MOD Reactor have been calculated and compared with available measured values. they were in good agreement. Also changes in reactivity have been calculated during operations at higher power levels than the present one, concluding some practical consequences for the case of increasing the present power of this reactor. (Author)

  18. Spectroscopic system for impurity measurements in the TJ-1 Tokamak of JEN; Un sistema espectroscopico para medidas de impurezas en el Tokamak TJ-1 de la JEN

    Energy Technology Data Exchange (ETDEWEB)

    Navas, G; Zurro, B

    1982-07-01

    we describe a spectroscopic system with spatial resolution capability that has been configured for plasma diagnostic in the TJ-1 Tokamak of JEN. The experimental system, based on a one meter monochromator, has been absolutely calibrated using a tungsten-halogen lamp. The calibration procedures and the absolute spectral sensitivity are presented as well as its dependence with the polarization. A simplified spectroscopic model of the radiation emitted by the intrinsic plasma impurities (C, 0, . . . ) has been developed. A one dimensional model of the temporal evolution of various ionization stages in coronal equilibrium is used to predict the electron temperature and impurity concentration. This model has been applied to experimental data from several Tokamaks. (Author) 23 refs.

  19. Innovate the Teaching of Taiwaness History: An Application of Multimedia Distance Learning—A Web-site Construction Sample of Shih Hsin University

    Directory of Open Access Journals (Sweden)

    Shaw-Fong Lee

    2004-03-01

    Full Text Available Traditionally, the teaching of history course mostly utilizes face to face instruction and oral presentation. Along with the development of educational technology, the teaching methods could be more various such as using internet and multimedia. Literature reviews also indicate that using internet and multimedia may improve the effect of learning and teaching. This paper explores the development of a web-based instructional system for the course of Taiwanese History at Shih Hsin University.The result and the product of this development project is the web site, http://distance.shu.edu.tw/taiwan/list.htm. The content of the web-site includes instructional materials such as animations, videos, pictures, texts, historical maps, and so on. The developmental methods used in this project use curriculum design, survey, interview, review of literatures and focus group discussion.[Article content in Chinese

  20. Levey-Jennings Analysis Uncovers Unsuspected Causes of Immunohistochemistry Stain Variability.

    Science.gov (United States)

    Vani, Kodela; Sompuram, Seshi R; Naber, Stephen P; Goldsmith, Jeffrey D; Fulton, Regan; Bogen, Steven A

    Almost all clinical laboratory tests use objective, quantitative measures of quality control (QC), incorporating Levey-Jennings analysis and Westgard rules. Clinical immunohistochemistry (IHC) testing, in contrast, relies on subjective, qualitative QC review. The consequences of using Levey-Jennings analysis for QC assessment in clinical IHC testing are not known. To investigate this question, we conducted a 1- to 2-month pilot test wherein the QC for either human epidermal growth factor receptor 2 (HER-2) or progesterone receptor (PR) in 3 clinical IHC laboratories was quantified and analyzed with Levey-Jennings graphs. Moreover, conventional tissue controls were supplemented with a new QC comprised of HER-2 or PR peptide antigens coupled onto 8 μm glass beads. At institution 1, this more stringent analysis identified a decrease in the HER-2 tissue control that had escaped notice by subjective evaluation. The decrement was due to heterogeneity in the tissue control itself. At institution 2, we identified a 1-day sudden drop in the PR tissue control, also undetected by subjective evaluation, due to counterstain variability. At institution 3, a QC shift was identified, but only with 1 of 2 controls mounted on each slide. The QC shift was due to use of the instrument's selective reagent drop zones dispense feature. None of these events affected patient diagnoses. These case examples illustrate that subjective QC evaluation of tissue controls can detect gross assay failure but not subtle changes. The fact that QC issues arose from each site, and in only a pilot study, suggests that immunohistochemical stain variability may be an underappreciated problem.

  1. Elbereth. A soubroutine library for graphic representation from J.E.N. Fusion Division

    International Nuclear Information System (INIS)

    Guasp, J.

    1981-01-01

    A library for graphic representation, named Elbereth, has been built, all the subroutines have been written in Fortran-V for the Univac-1100/80 computer from J.E.N. and are able to produce drawing on the Calcomp-936 plotter, as well as with the printers and on the UTS-400 terminal screen. The library can yield two or three-dimensional plots as well as level lines, all of them under free format or in several standard ones either. It allows to be used on a simplified way by direct reading from a file. It has been constructed too with a flexible structure to allow forthcoming extensions. (author)

  2. A min-max variational principle

    International Nuclear Information System (INIS)

    Georgiev, P.G.

    1995-11-01

    In this paper a variational principle for min-max problems is proved that is of the same spirit as Deville-Godefroy-Zizler's variational principle for minimization problems. A localization theorem in which the mini-max points for the perturbed function with respect top a given ε-min-max point are localized is presented. 3 refs

  3. The transport of carboxylic acids and important role of the Jen1p transporter during the development of yeast colonies

    Czech Academy of Sciences Publication Activity Database

    Paivo, S.; Strachotová, Dita; Kučerová, Helena; Hlaváček, Otakar; Mota, A.; Casal, M.; Palková, Z.; Váchová, Libuše

    2013-01-01

    Roč. 454, SEP 2013 (2013), s. 551-558 ISSN 0264-6021 R&D Projects: GA ČR GA204/08/0718 Institutional support: RVO:61388971 Keywords : ammonia production * Jen1p protein * monocarboxylic acid import Subject RIV: CE - Biochemistry Impact factor: 4.779, year: 2013

  4. Jens Baggesen voyageur en France. Un regard amusé et satirique sur la France révolutionnaire

    DEFF Research Database (Denmark)

    Schøsler, Jørn

    2011-01-01

    Jens Baggesens rejse i det revolutionære Frankrig i januar 1790 viser hans humor og satiriske gemyt i hans syn på franskmændene. Hans humoristiske vinkel afslører et manglende politisk engagement i de dramatiske begivenheder....

  5. Review: Jens Brockmeier (2015. Beyond the Archive: Memory, Narrative, and the Autobiographical Process

    Directory of Open Access Journals (Sweden)

    Lucas Bietti

    2016-08-01

    Full Text Available Jens BROCKMEIER's new book proposes a very provocative aim for memory studies: "[T]o radically re-think our very idea of memory and challenge the notions of remembering and forgetting that we have taken for granted" (p.vii. The main target for the author's critique is the archival model of memory. In order to support his approach, the author provides empirical evidence from the neurosciences, social sciences, and humanities. "Beyond the Archive" represents an innovative contribution to the field of memory studies. It brings together disparate disciplinary fields in a novel and sophisticated fashion with a clear goal in mind: to propose a new model for the analysis of autobiographical remembering. BROCKMEIER's book is a true exercise of multidisciplinary research in action, which is much needed in the current climate of psychological and neuroscientific reductionism in the sciences of memory. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs160338

  6. Spectroscopic system for impurity measurements in the TJ-1 Tokamak of JEN

    International Nuclear Information System (INIS)

    Navas, G.; Zurro, B.

    1982-01-01

    we describe a spectroscopic system with spatial resolution capability that has been configured for plasma diagnostic in the TJ-1 Tokamak of JEN. The experimental system, based on a one meter monochromator, has been absolutely calibrated using a tungsten-halogen lamp. The calibration procedures and the absolute spectral sensitivity are presented as well as its dependence with the polarization. A simplified spectroscopic model of the radiation emitted by the intrinsic plasma impurities (C, 0, . . . ) has been developed. A one dimensional model of the temporal evolution of various ionization stages in coronal equilibrium is used to predict the electron temperature and impurity concentration. This model has been applied to experimental data from several Tokamaks. (Author) 23 refs

  7. KEHONKUVA JA MEDIA : 9.-luokkalaisten tyttöjen kehonkuva ja median vaikutus siihen

    OpenAIRE

    Vainionpää, Charlotta; Koski, Riikka

    2016-01-01

    Tämän tutkimuksen aiheena oli kehonkuva ja media: 9.-luokkalaisten tyttöjen kehonkuva ja median vaikutus siihen. Tutkimuksen tarkoituksena oli selvittää minkälaisena tytöt kokevat oman kehonkuvansa, minkälaisia ulkonäköpaineita tytöillä on ja miten media vaikuttaa heidän kehonkuvaansa. Työn teoreettisessa viitekehyksessä pääkäsitteet olivat nuoruus, kehonkuva ja media. Nuoruus-osiossa käsiteltiin nuoruuden määrittelyn lisäksi murrosikää ja murrosiän fyysisiä sekä psyykkisiä muutoksia. Keh...

  8. Experience at J.E.N. with electrochemical cells for measurement of oxygen activity

    International Nuclear Information System (INIS)

    La Torre, M.de; Lapena, J.; Couchoud, M.

    1981-01-01

    The experience gained at the J.E.N. with oxygen meters since 1974 till 1980 is presented. Thirteen oxygen meters were tested. Eight with Cu/Cu/ 2 O reference electrode and the rest with Sn/SnO 2 , and two types of electrolyte tube produced by zircoa under specifications development by UNC and HEDL. The cells equiped with Cu/Cu 2 O showed an anomalous performance giving an e.m.f. higher than the theoretical value, and one of them was in close agreement to cells using air as reference electrode. An explanation is given. The performance of the cells with Sn/SnO 2 is in good agreement with those obtained in others laboratories. To calculate the theoretical value, it has derived a correlation colubility for oxygen with 262 data obtained by the vacuum distillation method. Various recommendations are pointed out on the future development of the oxygen meters to improve its performance. (author)

  9. Experience at JEN with electrochemical cells for measurement of oxygen activity in liquid sodium

    International Nuclear Information System (INIS)

    De la Torre, M.; Lapena, J.; Couchoud, M.

    1981-01-01

    This report presents the experience gained at the JEN with Oxygen Meters since 1974 till 1980. Thirteen O.H. were tested. Eight with Cu/Cu 2 O reference electrode and the rest with Sn/SnO 2 , and two types of electrolyte tube produced by Zircon under specifications development by UNC and HEDL. The cells equipped with Cu/Cu 2 O showed an anomalous performance giving an e.m.f. higher than the theoretical value, and one of them was in close agreement cells using air as reference electrode. An explanation is given. The performance of the cells with Sn/SnO 2 is in good agreement with those obtained in others laboratories. To calculate the theoretical value, it has derived a correlation solubility for oxygen with 262 data obtained by the vacuum distillation on method. Various recommendations are pointed out on the future development of the O.H. to improve its performance. (Author) 25 refs

  10. The effect of some organic substances on the mycelium of the fungus Ustilago nuda (Jens.) Rostr.

    Science.gov (United States)

    Krátká, J

    1976-01-01

    Research was performed for studying the effect of some organic compounds, considered by many authors as the products ob barley seed metabolism generated after anaerobic seed treatment, on the mycelium of the fungus Ustilago nuda (Jens.) Rostr. The author examined the effectiveness of ethylacohol, acetaldehyde, acetic acid, succinic acid, lactic acid, and hydroquinone in concentrations from 1 M to 10(-6) M, and the effectiveness of extracts from disinfected seeds in doses from 10 g to 0.001 g/l. The effect of the mentioned solutions was examined as exerted on the growth of dicaryotic mycelium and on the growth of the haploid promycelium of the fungus. The dicaryotic mycelium of Ustilago nuda (Jens.) Rostr. was cultivated on potato agar with benzoic acid. The presence of the acid prevents mitosis, and the chlamydospores germinate on the nutritive medium with two fibres having binuclear cells. The haploid promycelium was cultivated on potato agar; chlamydospores germinated with one four-cell fibre, and individual cells are mononuclear and haploid. Only later, a dicarytic mycelium is created in a complex process. In all the substances used, the concentration of 1 M was found to stop further growth of mycelium. The concentration of 10(-1) M of acetic acid and hydroquinone also stopped growth, the same concentration of acetaldehyde, lactic acid, succinic acid, ethylacohol stimulated mycelium growth in comparison with the control. The concentration of 10(-6) M stimulated mycelium growth in a majority of cases. Extracts from disinfected seeds did not influence mycelium growth significantly in all cases in comparison with the control. The results were similar in the two types of mycelium.

  11. Gender Difference in the Interaction Effects of Diabetes and Hypertension on Stroke among the Elderly in the Shih-Pai Study, Taiwan.

    Directory of Open Access Journals (Sweden)

    Yun-Ju Lai

    Full Text Available To investigate the interaction effects of diabetes and hypertension on stroke, and also investigate the independent and interaction effects of parental history and environmental factors on diabetes and hypertension in a cross-sectional elderly population.The Shih-Pai Community Medical Service Program was a community-based, fixed cohort study conducted between June 1999 and November 2002. Socio-demographic and clinical data of subjects aged 65 years and older were collected by well-trained interviewers during home visits. Interaction effects were analyzed using Rothman's synergy index (SI.In total, 4,124 subjects were included in the study, with 2,284 males and 1,840 females. The synergistic interaction of diabetes and hypertension on stroke was statistically significant in women (SI = 3.16, 95% CI: 1.35-7.39. The synergistic interaction of parental diabetes and being overweight on diabetes was only statistically significant in men, and not in women (SI = 3.30, 95% CI: 1.00-10.83 in men, and SI = 1.15, 95% CI: 0.30-4.39 in women.A synergistic interaction was found for diabetes and hypertension in both sexes when parental history and being overweight were combined. Furthermore, combining diabetes and hypertension in elderly women was significant in terms of the risk of stroke. Strategies to control risk factors in individuals at additional high risk are urgently needed.

  12. 30-min x 30-min Terrestrial Mean Free-Air Anomalies

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The 30-min x 30-min Terrestrial Mean Free-Air Gravity Anomaly and Geoid Undulations Data Base was compiled and developed by the Ohio State University. This data base...

  13. Quantum Max-flow/Min-cut

    Energy Technology Data Exchange (ETDEWEB)

    Cui, Shawn X., E-mail: xingshan@math.ucsb.edu [Department of Mathematics, University of California, Santa Barbara, California 93106 (United States); Quantum Architectures and Computation Group, Microsoft Research, Redmond, Washington 98052 (United States); Freedman, Michael H., E-mail: michaelf@microsoft.com [Department of Mathematics, University of California, Santa Barbara, California 93106 (United States); Microsoft Research, Station Q, University of California, Santa Barbara, California 93106 (United States); Sattath, Or, E-mail: sattath@gmail.com [Computer Science Division, University of California, Berkeley, California 94720 (United States); Stong, Richard, E-mail: stong@ccrwest.org; Minton, Greg, E-mail: gtminto@ccrwest.org [Center for Communications Research, La Jolla, California 92121 (United States)

    2016-06-15

    The classical max-flow min-cut theorem describes transport through certain idealized classical networks. We consider the quantum analog for tensor networks. By associating an integral capacity to each edge and a tensor to each vertex in a flow network, we can also interpret it as a tensor network and, more specifically, as a linear map from the input space to the output space. The quantum max-flow is defined to be the maximal rank of this linear map over all choices of tensors. The quantum min-cut is defined to be the minimum product of the capacities of edges over all cuts of the tensor network. We show that unlike the classical case, the quantum max-flow=min-cut conjecture is not true in general. Under certain conditions, e.g., when the capacity on each edge is some power of a fixed integer, the quantum max-flow is proved to equal the quantum min-cut. However, concrete examples are also provided where the equality does not hold. We also found connections of quantum max-flow/min-cut with entropy of entanglement and the quantum satisfiability problem. We speculate that the phenomena revealed may be of interest both in spin systems in condensed matter and in quantum gravity.

  14. Quantum Max-flow/Min-cut

    Science.gov (United States)

    Cui, Shawn X.; Freedman, Michael H.; Sattath, Or; Stong, Richard; Minton, Greg

    2016-06-01

    The classical max-flow min-cut theorem describes transport through certain idealized classical networks. We consider the quantum analog for tensor networks. By associating an integral capacity to each edge and a tensor to each vertex in a flow network, we can also interpret it as a tensor network and, more specifically, as a linear map from the input space to the output space. The quantum max-flow is defined to be the maximal rank of this linear map over all choices of tensors. The quantum min-cut is defined to be the minimum product of the capacities of edges over all cuts of the tensor network. We show that unlike the classical case, the quantum max-flow=min-cut conjecture is not true in general. Under certain conditions, e.g., when the capacity on each edge is some power of a fixed integer, the quantum max-flow is proved to equal the quantum min-cut. However, concrete examples are also provided where the equality does not hold. We also found connections of quantum max-flow/min-cut with entropy of entanglement and the quantum satisfiability problem. We speculate that the phenomena revealed may be of interest both in spin systems in condensed matter and in quantum gravity.

  15. Dynamic assembly of MinD on phospholipid vesicles regulated by ATP and MinE

    OpenAIRE

    Hu, Zonglin; Gogol, Edward P.; Lutkenhaus, Joe

    2002-01-01

    Selection of the division site in Escherichia coli is regulated by the min system and requires the rapid oscillation of MinD between the two halves of the cell under the control of MinE. In this study we have further investigated the molecular basis for this oscillation by examining the interaction of MinD with phospholipid vesicles. We found that MinD bound to phospholipid vesicles in the presence of ATP and, upon binding, assembled into a well-ordered helical array that deformed the vesicle...

  16. Calculations of Changes in Reactivity during some regular periods of operation of JEN-1 MOD Reactor; Calculo de vairaciones de reactividad en algunos periodos regulares de operacion del reactor JEN-1 Mod.

    Energy Technology Data Exchange (ETDEWEB)

    Alcala Ruiz, F

    1973-07-01

    By a Point-Reactor model and Perturbation Theory, changes in reactivity during some regular operating periods of JEN-1 MOD Reactor have been calculated and compared with available measured values. they were in good agreement. Also changes in reactivity have been calculated during operations at higher power levels than the present one, concluding some practical consequences for the case of increasing the present power of this reactor. (Author)

  17. Toward a Pragmatist Epistemology: Arthur O. Lovejoy's and H. S. Jennings's Biophilosophical Responses to Neovitalism, 1909-1914.

    Science.gov (United States)

    Russell, Doug

    2015-01-01

    The sustained interdisciplinary debate about neovitalism between two Johns Hopkins University colleagues, philosopher Arthur O. Lovejoy and experimental geneticist H. S. Jennings, in the period 1911-1914, was the basis for their theoretical reconceptualization of scientific knowledge as contingent and necessarily incomplete in its account of nature. Their response to Hans Driesch's neovitalist concept of entelechy, and his challenge to the continuity between biology and the inorganic sciences, resulted in a historically significant articulation of genetics and philosophy. This study traces the debate's shift of problem-focus away from neovitalism's threat to the unity of science - "organic autonomy," as Lovejoy put it - and toward the potential for development of a nonmechanististic, nonrationalist theory of scientific knowledge. The result was a new pragmatist epistemology, based on Lovejoy's and Jennings's critiques of the inadequacy of pragmatism's account of scientific knowledge. The first intellectual move, drawing on naturalism and pragmatism, was based on a reinterpretation of science as organized experience. The second, sparked by Henri Bergson's theory of creative evolution, and drawing together elements of Dewey's and James's pragmatisms, produced a new account of the contingency and necessary incompleteness of scientific knowledge. Prompted by the neovitalists' mix of a priori concepts and, in Driesch's case, and adherence to empiricism, Lovejoy's and Jennings's developing pragmatist epistemologies of science explored the interrelation between rationalism and empiricism.

  18. An Image of Britain during the Second World War: The films of Humphrey Jennings (1939-1945 Une image de la Grande-Bretagne pendant la Seconde Guerre mondiale : les films de Humphrey Jennings (1939-1945

    Directory of Open Access Journals (Sweden)

    Elena Von Kassel

    2009-10-01

    Full Text Available Il s’agit de chercher à comprendre comment le style poétique a pu atteindre des sommets avec les films de Humphrey Jennings dans le documentaire anglais et comment ces films résultent d’un mélange entre deux traditions du cinéma britannique, traditions jusque-là opposées. A l’initiative d’Alberto Cavalcanti, en 1939, The First Days, coréalisé par Humphrey Jennings, Harry Watt et Pat Jackson, fut, au tout début la guerre, le premier film offrant une réflexion sur des réalités, lorsque l’on avait essayé de manipuler le public dans Le lion a des ailes, tourné la même année, mais aussi  le premier film anglais de propagande de la Seconde Guerre mondiale, dont Alexander Korda avait lancé et soutenu la réalisation. Quand, partant pour Ealing Studios, Cavalcanti quitte la direction de la GPO Film Unit, il est remplacé par Ian Dalrymple, le producteur du film Le lion a des ailes. C’est sous la direction de Dalrymple qu’au GPO, désormais appelé Crown Film Unit, un nouveau genre de film put émerger. Dans cet esprit démocratique, après The First Days, fut tourné en coréalisation London Can Take It (1940, par Humphrey Jennings et Harry Watt, le thème portant sur la façon dont les Londoniens supportaient les bombardements. Puis, Jennings a réalisé Heart of Britain, le thème portant, cette fois, sur la résistance de toute l’Angleterre. Words for Battle, qui suivit, était un film de propagande historique. Toutefois, c’est avec Listen to Britain, en 1942, que Jennings put vraiment toucher le public. La guerre n’était pas encore gagnée, mais la propagande dans le documentaire anglais était bien plus efficace que celle de l’ennemi, et parvenait, en même temps, à toucher toutes les couches de la population.

  19. Perhetekijöiden yhteys 8.- ja 9.-luokkalaisten tyttöjen ja poikien itsearvioituun ahdistuneisuuteen -Kouluterveyskysely 2013

    OpenAIRE

    Peltola, Anniina

    2016-01-01

    Suomessa on tutkittu paljon perhetekijöiden ja perhesuhteiden muutosten yhteyksiä lasten hyvinvointiin. Perherakenteiden kuten vuoroasumisen yhteyttä lasten hyvinvointiin on Suomessa tutkittu vähemmän. Tämän tutkimuksen tarkoituksena oli kuvata 8.- ja 9.-luokkalaisten tyttöjen ja poikien perhetekijöitä ja itsearvioitua ahdistuneisuutta sekä niiden välistä yhteyttä. Lisäksi oli tarkoitus tutkia taustatekijöiden yhteyttä itsearvioituun ahdistuneisuuteen. Saatua tietoa voidaan hyödyntää kouluter...

  20. ABB Oy Motors and Generators -yksikön energiansyöttöjen erotus- ja lukitusohjeet

    OpenAIRE

    Chi, Henri

    2017-01-01

    Tämä insinöörityö toteutettiin Quant Finland Oy:lle, joka vastaa Helsingin Pitäjänmäen ABB Motors and Generators -tehtaan kunnossapidosta. Insinöörityön tavoitteena oli luoda energiansyöttöjen lukitus- ja erotusohjeet tehtaan koneistoille, laitteille ja järjestelmille. Tehtaalla on isoja koneita ja laitteita, jonka erotus- ja lukitustoimenpiteitä kaikki eivät osaa. Näin ollen on haluttu mahdollistaa turvallinen työskentely tarjoamalla selkeät erotus- ja lukitusohjeet. ABB Motors and Gene...

  1. Performance analysis of 60-min to 1-min integration time rain rate conversion models in Malaysia

    Science.gov (United States)

    Ng, Yun-Yann; Singh, Mandeep Singh Jit; Thiruchelvam, Vinesh

    2018-01-01

    Utilizing the frequency band above 10 GHz is in focus nowadays as a result of the fast expansion of radio communication systems in Malaysia. However, rain fade is the critical factor in attenuation of signal propagation for frequencies above 10 GHz. Malaysia is located in a tropical and equatorial region with high rain intensity throughout the year, and this study will review rain distribution and evaluate the performance of 60-min to 1-min integration time rain rate conversion methods for Malaysia. Several conversion methods such as Segal, Chebil & Rahman, Burgeono, Emiliani, Lavergnat and Gole (LG), Simplified Moupfouma, Joo et al., fourth order polynomial fit and logarithmic model have been chosen to evaluate the performance to predict 1-min rain rate for 10 sites in Malaysia. After the completion of this research, the results show that Chebil & Rahman model, Lavergnat & Gole model, Fourth order polynomial fit and Logarithmic model have shown the best performances in 60-min to 1-min rain rate conversion over 10 sites. In conclusion, it is proven that there is no single model which can claim to perform the best across 10 sites. By averaging RMSE and SC-RMSE over 10 sites, Chebil and Rahman model is the best method.

  2. Correlates of self-report chronic insomnia disorders with 1-6 month and 6-month durations in home-dwelling urban older adults - the Shih-Pai Sleep Study in Taiwan: a cross-sectional community study.

    Science.gov (United States)

    Chiou, Jing-Hui; Chen, Hsi-Chung; Chen, Kuang-Hung; Chou, Pesus

    2016-06-03

    To examine the correlates of insomnia disorder with different durations in home-dwelling older adults. A cross-sectional survey in the Shih-Pai area of Taipei City, Taiwan (The Shih-Pai Sleep Study). A total 4047 subjects over the age of 65 years completed the study (2259 men and 1788 women). The Pittsburgh Sleep Quality Index and the duration of insomnia symptoms were used to identify DSM-IV 1-6 month and 6-month insomnia disorders. The prevalence of DSM-IV defined insomnia disorder was 5.8 %; two-thirds of these case lasted for ≥6 months. The shared correlates for both 1-6 and 6-month insomnia disorders were gender (women), depression and moderate pain. Pulmonary diseases were exclusively associated with 1-6 month insomnia disorder (OR: 2.57, 95 % CI: 1.46-4.52). In contrast, heart disease (OR: 1.73, 95 % CI: 1.21-2.49) and severe pain (OR: 2.34, 95 % CI: 1.14-4.40) were associated with 6-month insomnia disorder. The prevalence of persistent insomnia disorder is higher than short-term insomnia disorder. Correlates for less persistent and more persistent insomnia disorder appears to be partially different. Duration quantifiers may be important in the identification of the etiology of insomnia and further studies with follow-ups are needed to examine the order of developing insomnia disorder and associated conditions.

  3. Min-Max Spaces and Complexity Reduction in Min-Max Expansions

    Energy Technology Data Exchange (ETDEWEB)

    Gaubert, Stephane, E-mail: Stephane.Gaubert@inria.fr [Ecole Polytechnique, INRIA and CMAP (France); McEneaney, William M., E-mail: wmceneaney@ucsd.edu [University of California San Diego, Dept. of Mech. and Aero. Eng. (United States)

    2012-06-15

    Idempotent methods have been found to be extremely helpful in the numerical solution of certain classes of nonlinear control problems. In those methods, one uses the fact that the value function lies in the space of semiconvex functions (in the case of maximizing controllers), and approximates this value using a truncated max-plus basis expansion. In some classes, the value function is actually convex, and then one specifically approximates with suprema (i.e., max-plus sums) of affine functions. Note that the space of convex functions is a max-plus linear space, or moduloid. In extending those concepts to game problems, one finds a different function space, and different algebra, to be appropriate. Here we consider functions which may be represented using infima (i.e., min-max sums) of max-plus affine functions. It is natural to refer to the class of functions so represented as the min-max linear space (or moduloid) of max-plus hypo-convex functions. We examine this space, the associated notion of duality and min-max basis expansions. In using these methods for solution of control problems, and now games, a critical step is complexity-reduction. In particular, one needs to find reduced-complexity expansions which approximate the function as well as possible. We obtain a solution to this complexity-reduction problem in the case of min-max expansions.

  4. Dynamic assembly of MinD into filament bundles modulated by ATP, phospholipids, and MinE

    OpenAIRE

    Suefuji, Kyoko; Valluzzi, Regina; RayChaudhuri, Debabrata

    2002-01-01

    Accurate positioning of the division septum at the equator of Escherichia coli cells requires a rapid oscillation of MinD ATPase between the polar halves of the cell membrane, together with the division inhibitor MinC, under MinE control. The mechanism underlying MinD oscillation remains poorly understood. Here, we demonstrate that purified MinD assembles into protein filaments in the presence of ATP. Incubation with phospholipid vesicles further stimulates MinD polymerization. Addition of pu...

  5. Prometeo I. A program for averaging thermal constants over a Wigner-Wilkins flux spectrum on the Univac UCT of J.E.N

    International Nuclear Information System (INIS)

    Corella, M. R.; Iglesias, T.

    1964-01-01

    The Prometeo I program for the Univac UCT of J.E.N., determines the spectrum of thermal neutrons in equilibrium with a hydrogen-moderated homogeneous mixture from the Wigner-Wilkins differential equation, and averages various, cross sections over the spectrum. The present cross section libraries, available for the Prometeo I , are tabulated. (Author) 4 refs

  6. Researches on detection of barley varieties and lines against Ustilago nuda hordei “Jens.â€? Rostr. Schaffn.in Marmara Region

    OpenAIRE

    Gümüştekin, H.; Akın, K.

    2008-01-01

    This research has been started in 1994 to test barley varieties and lines against Ustilago nuda hordei “Jens.â€? Rostr. Schaffn. In 1994, 14 barley varieties and lines and in 1995 23 barley varieties and lines were tested. After testing 37 varieties and lines, 27 of them were found resistant (R), and 10 of them susceptible (S).

  7. Václav Cílek: Zchudnutí lidstva by bylo jen návratem k normálu [Rozhovor

    Czech Academy of Sciences Publication Activity Database

    Tuček, J.; Cílek, Václav

    2010-01-01

    Roč. 4, 2010.06.25 (2010), s. 1-3 ISSN 1803-4543 Institutional research plan: CEZ:AV0Z30130516 Keywords : mineral resources * oil * oil accidents * global changes Subject RIV: DB - Geology ; Mineralogy http://www.e15.cz/nazory/rozhovory/vaclav-cilek-zchudnuti-lidstva-by-bylo-jen-navratem-k-normalu

  8. Supporting the human life-raft in confronting the juggernaut of technology: Jens Rasmussen, 1961-1986.

    Science.gov (United States)

    Kant, Vivek

    2017-03-01

    Jens Rasmussen's contribution to the field of human factors and ergonomics has had a lasting impact. Six prominent interrelated themes can be extracted from his research between 1961 and 1986. These themes form the basis of an engineering epistemology which is best manifested by his abstraction hierarchy. Further, Rasmussen reformulated technical reliability using systems language to enable a proper human-machine fit. To understand the concept of human-machine fit, he included the operator as a central component in the system to enhance system safety. This change resulted in the application of a qualitative and categorical approach for human-machine interaction design. Finally, Rasmussen's insistence on a working philosophy of systems design as being a joint responsibility of operators and designers provided the basis for averting errors and ensuring safe and correct system functioning. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. La tradición en la teología de Jenófanes Tradition in Xenophanes's theology

    Directory of Open Access Journals (Sweden)

    Carlos Gustavo Carrasco Meza

    2010-01-01

    Full Text Available Este trabajo busca tanto relacionar la teología de Jenófanes con la cosmovisión heredada de la épica, como encontrar vestigios de la nueva religiosidad griega del siglo VI a. C. La posibilidad de hallar rastros de pitagorismo en los fragmentos nos obliga a postular la relación necesaria entre la defensa de una nueva fe y la crítica a la religión tradicional. Jenófanes atribuye cuatro características a dios: unicidad, inmovilidad, espiritualidad, eternidad. Es posible ver en la obra de Homero una prefiguración de algunos de estos atributos y es posible, además, reconocer en ellos la influencia de las nuevas corrientes mistéricas que reformularon algunos de los conceptos religiosos tradicionales o los rechazaron, dada la incompatibilidad entre la inmoralidad y la divinidad.This article attempts to relate theology of Xenophanes with worldview that goes back to epic poetry and to find traces of new religiosity in century VI B. C. Possibility to find traces of Pythagorism in fragmente forces us to suggest a necessary relation between defense of a new faith and criticism of traditional religión. Xenophanes ascribes to god four characteristics: oneness, immobility, spirituality, eternity. It is possible to find in Homer's work a precedent of some attributes and it is possible too to recognize innuence of new mystery religions that reform many religious concepts or reject them because of incompatibility between immorality and divinity.

  10. Simple membrane-based model of the Min oscillator

    International Nuclear Information System (INIS)

    Petrášek, Zdeněk; Schwille, Petra

    2015-01-01

    Min proteins in E. coli bacteria organize into a dynamic pattern oscillating between the two cell poles. This process identifies the middle of the cell and enables symmetric cell division. In an experimental model system consisting of a flat membrane with effectively infinite supply of proteins and energy source, the Min proteins assemble into travelling waves. Here we propose a simple one-dimensional model of the Min dynamics that, unlike the existing models, reproduces the sharp decrease of Min concentration when the majority of protein detaches from the membrane, and even the narrow MinE maximum immediately preceding the detachment. The proposed model thus provides a possible mechanism for the formation of the MinE ring known from cells. The model is restricted to one dimension, with protein interactions described by chemical kinetics allowing at most bimolecular reactions, and explicitly considering only three, membrane-bound, species. The bulk solution above the membrane is approximated as being well-mixed, with constant concentrations of all species. Unlike other models, our proposal does not require autocatalytic binding of MinD to the membrane. Instead, it is assumed that two MinE molecules are necessary to induce the dissociation of the MinD dimer and its subsequent detachment from the membrane. We investigate which reaction schemes lead to unstable homogeneous steady states and limit cycle oscillations, and how diffusion affects their stability. The suggested model qualitatively describes the shape of the Min waves observed on flat membranes, and agrees with the experimental dependence of the wave period on the MinE concentration. These results highlight the importance of MinE presence on the membrane without being bound to MinD, and of the reactions of Min proteins on the membrane. (paper)

  11. Timing matters: negative emotion elicited 5 min but not 30 min or 45 min after learning enhances consolidation of internal-monitoring source memory.

    Science.gov (United States)

    Wang, Bo; Bukuan, Sun

    2015-05-01

    Two experiments examined the time-dependent effects of negative emotion on consolidation of item and internal-monitoring source memory. In Experiment 1, participants (n=121) learned a list of words. They were asked to read aloud half of the words and to think about the remaining half. They were instructed to memorize each word and its associative cognitive operation ("reading" versus "thinking"). Immediately following learning they conducted free recall and then watched a 3-min either neutral or negative video clip when 5 min, 30 min or 45 min had elapsed after learning. Twenty-four hours later they returned to take surprise tests for item and source memory. Experiment 2 was similar to Experiment 1 except that participants, without conducting an immediate test of free recall, took tests of source memory for all encoded words both immediately and 24 h after learning. Experiment 1 showed that negative emotion enhanced consolidation of item memory (as measured by retention ratio of free recall) regardless of delay of emotion elicitation and that negative emotion enhanced consolidation of source memory when it was elicited at a 5 min delay but reduced consolidation of source memory when it was elicited at a 30 min delay; when elicited at a 45 min delay, negative emotion had little effect. Furthermore, Experiment 2 replicated the enhancement effect on source memory in the 5 min delay even when participants were tested on all the encoded words. The current study partially replicated prior studies on item memory and extends the literature by providing evidence for a time-dependent effect of negative emotion on consolidation of source memory based on internal monitoring. Copyright © 2015 Elsevier B.V. All rights reserved.

  12. John Ellis, Jens Vigen and Mick Storr on handmade knits made for CERN by high-school teachers Inga Hanne Dokka (Kongsberg videregående skole) and Jolanta Nylund (Akademiet Drammen)

    CERN Multimedia

    Pantelia, Anna

    2014-01-01

    Mick Storr wearing a pull-over made by high-school teacher Jolanta Nylund, Akademiet, Drammen. John Ellis and Jens Vigen in jumpers knitted by high-school teacher Inga Hanne Dokka Kongsberg videregående skole.

  13. Experience at JEN with electrochemical cells for measurement of oxygen activity in liquid sodium; Experiencia en la JEN con sondas electroquimicas para medida de la actividad del oxigeno disuelto en sodio liquido

    Energy Technology Data Exchange (ETDEWEB)

    Torre, M de la; Lapena, J; Couchoud, M

    1981-07-01

    This report presents the experience gained at the JEN with Oxygen Meters since 1974 till 1980. Thirteen O.H. were tested. Eight with Cu/Cu{sub 2}O reference electrode and the rest with Sn/SnO{sub 2}, and two types of electrolyte tube produced by Zircon under specifications development by UNC and HEDL. The cells equipped with Cu/Cu{sub 2}O showed an anomalous performance giving an e.m.f. higher than the theoretical value, and one of them was in close agreement cells using air as reference electrode. An explanation is given. The performance of the cells with Sn/SnO{sub 2} is in good agreement with those obtained in others laboratories. To calculate the theoretical value, it has derived a correlation solubility for oxygen with 262 data obtained by the vacuum distillation on method. Various recommendations are pointed out on the future development of the O.H. to improve its performance. (Author) 25 refs.

  14. Prometeo I. A program for averaging thermal constants over a Wigner-Wilkins flux spectrum on the Univac UCT of J.E.N.; Prometo I. Progrma para promediar las constantes termicas con el espectro Wigner-Wikins en la Univac UCT de la J.E.N.

    Energy Technology Data Exchange (ETDEWEB)

    Corella, M R; Iglesias, T

    1964-07-01

    The Prometeo I program for the Univac UCT of J.E.N., determines the spectrum of thermal neutrons in equilibrium with a hydrogen-moderated homogeneous mixture from the Wigner-Wilkins differential equation, and averages various, cross sections over the spectrum. The present cross section libraries, available for the Prometeo I , are tabulated. (Author) 4 refs.

  15. Deriving the Normalized Min-Sum Algorithm from Cooperative Optimization

    OpenAIRE

    Huang, Xiaofei

    2006-01-01

    The normalized min-sum algorithm can achieve near-optimal performance at decoding LDPC codes. However, it is a critical question to understand the mathematical principle underlying the algorithm. Traditionally, people thought that the normalized min-sum algorithm is a good approximation to the sum-product algorithm, the best known algorithm for decoding LDPC codes and Turbo codes. This paper offers an alternative approach to understand the normalized min-sum algorithm. The algorithm is derive...

  16. Oscillating behavior of Clostridium difficile Min proteins in Bacillus subtilis.

    Science.gov (United States)

    Makroczyová, Jana; Jamroškovič, Ján; Krascsenitsová, Eva; Labajová, Nad'a; Barák, Imrich

    2016-06-01

    In rod-shaped bacteria, the proper placement of the division septum at the midcell relies, at least partially, on the proteins of the Min system as an inhibitor of cell division. The main principle of Min system function involves the formation of an inhibitor gradient along the cell axis; however, the establishment of this gradient differs between two well-studied gram-negative and gram-positive bacteria. While in gram-negative Escherichia coli, the Min system undergoes pole-to-pole oscillation, in gram-positive Bacillus subtilis, proper spatial inhibition is achieved by the preferential attraction of the Min proteins to the cell poles. Nevertheless, when E.coli Min proteins are inserted into B.subtilis cells, they still oscillate, which negatively affects asymmetric septation during sporulation in this organism. Interestingly, homologs of both Min systems were found to be present in various combinations in the genomes of anaerobic and endospore-forming Clostridia, including the pathogenic Clostridium difficile. Here, we have investigated the localization and behavior of C.difficile Min protein homologs and showed that MinDE proteins of C.difficile can oscillate when expressed together in B.subtilis cells. We have also investigated the effects of this oscillation on B.subtilis sporulation, and observed decreased sporulation efficiency in strains harboring the MinDE genes. Additionally, we have evaluated the effects of C.difficile Min protein expression on vegetative division in this heterologous host. © 2016 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.

  17. Noise-induced Min phenotypes in E. coli.

    Directory of Open Access Journals (Sweden)

    David Fange

    2006-06-01

    Full Text Available The spatiotemporal oscillations of the Escherichia coli proteins MinD and MinE direct cell division to the region between the chromosomes. Several quantitative models of the Min system have been suggested before, but no one of them accounts for the behavior of all documented mutant phenotypes. We analyzed the stochastic reaction-diffusion kinetics of the Min proteins for several E. coli mutants and compared the results to the corresponding deterministic mean-field description. We found that wild-type (wt and filamentous (ftsZ- cells are well characterized by the mean-field model, but that a stochastic model is necessary to account for several of the characteristics of the spherical (rodA- and phospathedylethanolamide-deficient (PE- phenotypes. For spherical cells, the mean-field model is bistable, and the system can get trapped in a non-oscillatory state. However, when the intrinsic noise is considered, only the experimentally observed oscillatory behavior remains. The stochastic model also reproduces the change in oscillation directions observed in the spherical phenotype and the occasional gliding of the MinD region along the inner membrane. For the PE- mutant, the stochastic model explains the appearance of randomly localized and dense MinD clusters as a nucleation phenomenon, in which the stochastic kinetics at low copy number causes local discharges of the high MinD(ATP to MinD(ADP potential. We find that a simple five-reaction model of the Min system can explain all documented Min phenotypes, if stochastic kinetics and three-dimensional diffusion are accounted for. Our results emphasize that local copy number fluctuation may result in phenotypic differences although the total number of molecules of the relevant species is high.

  18. Projekti Min-E-Max kohtumine Saksamaal / Katrin Arge

    Index Scriptorium Estoniae

    Arge, Katrin

    2005-01-01

    Oktoobri keskel toimus Lõuna-Saksamaa väikelinnas Oberderdingenis Hispaania, Portugali, Ungari, Leedu, Eesti ja Saksamaa õpetajate kohtumine seoses Euroopa Liidu poolt rahastatava Comenius1 projektiga Min-E-Max (minimum energy input maximum output)

  19. 160-min solar pulsation recorded simultaneously by two radio telescopes

    International Nuclear Information System (INIS)

    Nesterov, N.S.; Urpo, S.; Kotov, V.A.

    1983-01-01

    Independent differential (center--limb) measurements of the brightness of the quiet sun on 1981 June 22 at lambda = 13.5 mm in the Crimea and at 8 mm in Finland show synchronous variations with 160-min periodicity

  20. Quantitative approach of Min protein researches and applications ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-12-29

    Dec 29, 2009 ... 4Institute of Molecular Biosciences, Mahidol University, Salaya Campus, Nakhon ... Numerous studies of Min protein dynamics have focused on dynamic spatial- .... techniques or by modeling and simulation (Rothfield et.

  1. The 1-min Screening Test for Reading Problems in College Students: Psychometric Properties of the 1-min TIL.

    Science.gov (United States)

    Fernandes, Tânia; Araújo, Susana; Sucena, Ana; Reis, Alexandra; Castro, São Luís

    2017-02-01

    Reading is a central cognitive domain, but little research has been devoted to standardized tests for adults. We, thus, examined the psychometric properties of the 1-min version of Teste de Idade de Leitura (Reading Age Test; 1-min TIL), the Portuguese version of Lobrot L3 test, in three experiments with college students: typical readers in Experiment 1A and B, dyslexic readers and chronological age controls in Experiment 2. In Experiment 1A, test-retest reliability and convergent validity were evaluated in 185 students. Reliability was >.70, and phonological decoding underpinned 1-min TIL. In Experiment 1B, internal consistency was assessed by presenting two 45-s versions of the test to 19 students, and performance in these versions was significantly associated (r = .78). In Experiment 2, construct validity, criterion validity and clinical utility of 1-min TIL were investigated. A multiple regression analysis corroborated construct validity; both phonological decoding and listening comprehension were reliable predictors of 1-min TIL scores. Logistic regression and receiver operating characteristics analyses revealed the high accuracy of this test in distinguishing dyslexic from typical readers. Therefore, the 1-min TIL, which assesses reading comprehension and potential reading difficulties in college students, has the necessary psychometric properties to become a useful screening instrument in neuropsychological assessment and research. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  2. MinT: Middleware for Cooperative Interaction of Things.

    Science.gov (United States)

    Jeon, Soobin; Jung, Inbum

    2017-06-20

    This paper proposes an Internet of Things (IoT) middleware called Middleware for Cooperative Interaction of Things (MinT). MinT supports a fully distributed IoT environment in which IoT devices directly connect to peripheral devices easily construct a local or global network, and share their data in an energy efficient manner. MinT provides a sensor abstract layer, a system layer and an interaction layer. These enable integrated sensing device operations, efficient resource management, and active interconnection between peripheral IoT devices. In addition, MinT provides a high-level API to develop IoT devices easily for IoT device developers. We aim to enhance the energy efficiency and performance of IoT devices through the performance improvements offered by MinT resource management and request processing. The experimental results show that the average request rate increased by 25% compared to Californium, which is a middleware for efficient interaction in IoT environments with powerful performance, an average response time decrease of 90% when resource management was used, and power consumption decreased by up to 68%. Finally, the proposed platform can reduce the latency and power consumption of IoT devices.

  3. ELBERETH. A subroutine library for graphic representation from J. E. N. Fusion Division; ELBERETH. Libreria de subrutinas para representacion grafica de la Division de Fusion de la JEN

    Energy Technology Data Exchange (ETDEWEB)

    Guasp, J

    1981-07-01

    A library for graphic representation, named ELBERETH, has been built, all the subroutines have been written in FORTRAN-V for the UN IVAC-1100/80 computers from JEN and are able to produce drawing on the CALCOMP-936 plotter, as well as with the printers and on the UTS-400 terminal screen. The library can yield two or three-dimensional plots as rail as level lines, all of them under free format or in several standard ones either. It allows to be used on a simplified way by direct reading from a file. It has been constructed too with a flexible structure to allow forth coming extensions. (Author) 4 refs.

  4. Min-Max decoding for non binary LDPC codes

    OpenAIRE

    Savin, Valentin

    2008-01-01

    Iterative decoding of non-binary LDPC codes is currently performed using either the Sum-Product or the Min-Sum algorithms or slightly different versions of them. In this paper, several low-complexity quasi-optimal iterative algorithms are proposed for decoding non-binary codes. The Min-Max algorithm is one of them and it has the benefit of two possible LLR domain implementations: a standard implementation, whose complexity scales as the square of the Galois field's cardinality and a reduced c...

  5. Min-max event-triggered computation tree logic

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    Temporal logic model-checking (Clarkeet al1986) is one of the most popular and well studied ... Min-max CTL, for reasoning about such extremal timing properties and showed .... A control flow decision is taken based on the value of one or more variables (like a ... We first present a few examples to informally explain the.

  6. Primary standards for measuring flow rates from 100 nl/min to 1 ml/min - gravimetric principle.

    Science.gov (United States)

    Bissig, Hugo; Petter, Harm Tido; Lucas, Peter; Batista, Elsa; Filipe, Eduarda; Almeida, Nelson; Ribeiro, Luis Filipe; Gala, João; Martins, Rui; Savanier, Benoit; Ogheard, Florestan; Niemann, Anders Koustrup; Lötters, Joost; Sparreboom, Wouter

    2015-08-01

    Microflow and nanoflow rate calibrations are important in several applications such as liquid chromatography, (scaled-down) process technology, and special health-care applications. However, traceability in the microflow and nanoflow range does not go below 16 μl/min in Europe. Furthermore, the European metrology organization EURAMET did not yet validate this traceability by means of an intercomparison between different National Metrology Institutes (NMIs). The NMIs METAS, Centre Technique des Industries Aérauliques et Thermiques, IPQ, Danish Technological Institute, and VSL have therefore developed and validated primary standards to cover the flow rate range from 0.1 μl/min to at least 1 ml/min. In this article, we describe the different designs and methods of the primary standards of the gravimetric principle and the results obtained at the intercomparison for the upper flow rate range for the various NMIs and Bronkhorst High-Tech, the manufacturer of the transfer standards used.

  7. ”KELPAANKO MÄ TÄLLAISENA KUIN OLEN?” : 13–17-vuotiaiden tyttöjen ajatuksia ulkonäöstä ja ulkonäköpaineista

    OpenAIRE

    Saikkonen, Heini; Rytilahti, Laura

    2017-01-01

    Rytilahti, Laura & Saikkonen, Heini. ”Kelpaanko mä tällaisena kuin olen?”. 13–17-vuotiaiden tyttöjen ajatuksia ulkonäöstä ja ulkonäköpaineista. Helsinki, kevät 2017, 57 s., 3 liitettä. Diakonia-ammattikorkeakoulu. Hoitotyön koulutusohjelma, sairaanhoitaja (AMK). Opinnäytetyö toteutettiin yhteistyössä Helsingin Tyttöjen Talon kanssa. Tutkimuksen tarkoituksena oli selvittää nuorten tyttöjen ajatuksia ulkonäöstä ja ulkonäköpaineista. Tutkimuksen avulla haluttiin selvittää nuorten mahdollisi...

  8. Edward W. Jennings | NREL

    Science.gov (United States)

    practices promoting a safe and supportive working environment. His research interests include environmental, safety, and health (ESH) and facility issues, he is responsible for implementing safe work plan; working directly with awardees by performing on-site validations to collect and analyze enzyme

  9. Promoting increased Chlorella sorokiniana Shih. et Krauss ...

    African Journals Online (AJOL)

    Prof. Nweze

    2014-12-31

    Dec 31, 2014 ... Also, the extract obtained from the leaves of Moringa in 80% ethanol contains growth enhancing principles for higher plants. (Makkar and Becker, 1996). In view of the fact that. Chlorella biomass is much sought after for use as health food supplement and for biofuels among other uses, enhanced production ...

  10. Scintigraphy of the Placenta With {sup 113m}In

    Energy Technology Data Exchange (ETDEWEB)

    Lewitus, Z.; Lubin, E.; Rechnic, J.; Laor, J.; Eckerling, E. [Beilinson Medical Centre, University of Tel Aviv School of Medicine (Israel)

    1969-05-15

    The paper describes the merits of using {sup 113m}In in scintigraphic placental localization. The {sup 113m}In, generated from a commercial {sup 113}Sn cow, eluted with 0.05N HC1, stabilized with gelatin at pH 4.0 and autoclaved in the carrier-free form, becomes bound to the plasma proteins after being injected intravenously and stays in the vascular system long enough to enable scanning of the placental blood pools. The short physical half-life and the decay by isomeric transition reduces the radiation dose compared with other scanning agents. The minimal elimination of the molecule into the bladder during scanning has the advantage over the use of {sup 99m}Tc because it diminishes the possible confusion of activity in this area with a low-lying placenta. The placentography has been found of value in the diagnosis of placenta praevia, twins and hydatidiform mole. (author)

  11. Fast Inference with Min-Sum Matrix Product.

    Science.gov (United States)

    Felzenszwalb, Pedro F; McAuley, Julian J

    2011-12-01

    The MAP inference problem in many graphical models can be solved efficiently using a fast algorithm for computing min-sum products of n × n matrices. The class of models in question includes cyclic and skip-chain models that arise in many applications. Although the worst-case complexity of the min-sum product operation is not known to be much better than O(n(3)), an O(n(2.5)) expected time algorithm was recently given, subject to some constraints on the input matrices. In this paper, we give an algorithm that runs in O(n(2) log n) expected time, assuming that the entries in the input matrices are independent samples from a uniform distribution. We also show that two variants of our algorithm are quite fast for inputs that arise in several applications. This leads to significant performance gains over previous methods in applications within computer vision and natural language processing.

  12. Oxford Nanopore MinION Sequencing and Genome Assembly

    Directory of Open Access Journals (Sweden)

    Hengyun Lu

    2016-10-01

    Full Text Available The revolution of genome sequencing is continuing after the successful second-generation sequencing (SGS technology. The third-generation sequencing (TGS technology, led by Pacific Biosciences (PacBio, is progressing rapidly, moving from a technology once only capable of providing data for small genome analysis, or for performing targeted screening, to one that promises high quality de novo assembly and structural variation detection for human-sized genomes. In 2014, the MinION, the first commercial sequencer using nanopore technology, was released by Oxford Nanopore Technologies (ONT. MinION identifies DNA bases by measuring the changes in electrical conductivity generated as DNA strands pass through a biological pore. Its portability, affordability, and speed in data production makes it suitable for real-time applications, the release of the long read sequencer MinION has thus generated much excitement and interest in the genomics community. While de novo genome assemblies can be cheaply produced from SGS data, assembly continuity is often relatively poor, due to the limited ability of short reads to handle long repeats. Assembly quality can be greatly improved by using TGS long reads, since repetitive regions can be easily expanded into using longer sequencing lengths, despite having higher error rates at the base level. The potential of nanopore sequencing has been demonstrated by various studies in genome surveillance at locations where rapid and reliable sequencing is needed, but where resources are limited.

  13. Decay of the 16.3 min Decay of the 16.3 min {sup 182}Ta Isomer

    Energy Technology Data Exchange (ETDEWEB)

    Hoejeberg, M [Inst. of Physics, Univ. of Stockholm, Stockholm (Sweden); Malmskog, S G [AB Atomenergi, Nykoeping (Sweden)

    1967-01-15

    Some transitions in the decay of the 16.3 min {sup 182}Ta isomer have been studied with a Ge(Li) detector and a double lens electron coincidence spectrometer. Gamma ray and conversion electron intensities were measured. From a delayed coincidence experiment it was concluded that both of the two lowest excited states in {sup 182}Ta had a half life less than 30 psec.

  14. Penerapan Manajemen Pembelajaran untuk Meningkatkan Kompetensi Guru di MIN Kendari

    Directory of Open Access Journals (Sweden)

    Rasmi Rasmi

    2016-05-01

    Full Text Available Abstract This study aims to reveal about how the implementation of learning management to improve the competence of teachers in MIN  Kendari, how the forms teacher competence, and the factors that support and hinder the implementation of learning management to improve the competence of teachers. The result showed that the implementation of learning management to improve the competence of teachers in MIN Kendari not been implemented optimally in the planning stages of learning, organizational learning, learning implementation, evaluation of learning.  There factors supporting the implementation of learning management to improve the competence of teachers that is flexible and democratic principals in leading institutions, teachers have an average qualified Tier One and a few teachers qualified master, increased professionalism and competence of teachers that are specifically has been carried out by the head MIN Kendari to include teachers conduct seminars, workshops, training, availability of CCTV, LCD. While inhibiting factorss still the lack of availability of books supporting, the unavailability of rooms in the main learning laboratory science and language subjects, still lack the skills of teachers in the use of learning technology tools, the double post by teachers, teachers in addition to functional positions are also burdened with additional duty structural position.   Keywords: Management, Learning, Teacher Competency   Abstrak   Penelitian ini bertujuan untuk mengungkap tentang bagaimana penerapan manajemen pembelajaran untuk meningkatkan kompetensi guru di Madrasah Ibtidaiyah Negeri (MIN Kendari, bagaimana bentuk-bentuk kompetensi guru, dan faktor-faktor yang mendukung dan menghambat. Dan jenis penelitian ini adalah penelitian lapangan yang sifatnya kualitatif deskriftif. Adapun sumber data dalam penelitian ini adalah guru-guru dan staf tata usaha MIN Kendari, sedangkan metode pengumpulan data dilakukan dengan observasi, wawancara

  15. Period 2 Mutation Accelerates ApcMin/+ Tumorigenesis

    Science.gov (United States)

    Wood, Patricia A.; Yang, Xiaoming; Taber, Andrew; Oh, Eun-Young; Ansell, Christine; Ayers, Stacy E.; Al-Assaad, Ziad; Carnevale, Kevin; Berger, Franklin G.; Peña, Maria Marjorette O.; Hrushesky, William J.M.

    2014-01-01

    Colorectal cancer risk is increased in shift workers with presumed circadian disruption. Intestinal epithelial cell proliferation is gated throughout each day by the circadian clock. Period 2 (Per2) is a key circadian clock gene. Per2 mutant (Per2m/m) mice show an increase in lymphomas and deregulated expression of cyclin D and c-Myc genes that are key to proliferation control. We asked whether Per2 clock gene inactivation would accelerate intestinal and colonic tumorigenesis. The effects of PER2 on cell proliferation and β-catenin were studied in colon cancer cell lines by its down-regulation following RNA interference. The effects of Per2 inactivation in vivo on β-catenin and on intestinal and colonic polyp formation were studied in mice with Per2 mutation alone and in combination with an Apc mutation using polyp-prone ApcMin/+ mice. Down-regulation of PER2 in colon cell lines (HCT116 and SW480) increases β-catenin, cyclin D, and cell proliferation. Down-regulation of β-catenin along with Per2 blocks the increase in cyclin D and cell proliferation. Per2m/m mice develop colonic polyps and show an increase in small intestinal mucosa β-catenin and cyclin D protein levels compared with wild-type mice. ApcMin/+Per2m/m mice develop twice the number of small intestinal and colonic polyps, with more severe anemia and splenomegaly, compared with ApcMin/+ mice. These data suggest that Per2 gene product suppresses tumorigenesis in the small intestine and colon by down-regulation of β-catenin and β-catenin target genes, and this circadian core clock gene may represent a novel target for colorectal cancer prevention and control. PMID:19010825

  16. An Analysis of the Max-Min Texture Measure.

    Science.gov (United States)

    1982-01-01

    PANC 33 D2 Confusion Matrices for Scene A, IR 34 D3 Confusion Matrices for Scene B, PANC 35 D4 Confusion Matrices for Scene B, IR 36 D5 Confusion...Matrices for Scene C, PANC 37 D6 Confusion Matrices for Scene C, IR 38 D7 Confusion Matrices for Scene E, PANC 39 D8 Confusion Matrices for Scene E, IR 40...D9 Confusion Matrices for Scene H, PANC 41 DIO Confusion Matrices for Scene H, JR 42 3 .D 10CnuinMtie o cn ,IR4 AN ANALYSIS OF THE MAX-MIN TEXTURE

  17. Chain rules for smooth min-and max-entropies

    DEFF Research Database (Denmark)

    Vitanov, Alexande; Dupont-Dupuis, Fréderic; Tomamichel, Marco

    2013-01-01

    The chain rule for the Shannon and von Neumann en- tropy, which relates the total entropy of a system to the entropies of its parts, is of central importance to information theory. Here, we consider the chain rule for the more general smooth min- and max-entropies, used in one-shot in formation...... theory. For these en- tropy measures, the chain rule no longer holds as an equality. How- ever, the standard chain rule for the von Neum ann entropy is re- trieved asymptotically when evaluating the smooth entropies for many identical and independently distributed states....

  18. Decree-Law No. 48568 of 4 September 1968 - Competence of the J.E.N. to undertake scientific and technical inspections of private or public bodies involved in nuclear research or nuclear activities

    International Nuclear Information System (INIS)

    1968-01-01

    Under this Decree-Law, the Junta de Energia Nuclear (JEN) is empowered to inspect on a regular basis all establishments and installations involved in nuclear activities. These inspections are made to ensure that the installations are operated safely and efficiently and that radiation protection measures are properly applied. (NEA) [fr

  19. MIN-CUT BASED SEGMENTATION OF AIRBORNE LIDAR POINT CLOUDS

    Directory of Open Access Journals (Sweden)

    S. Ural

    2012-07-01

    Full Text Available Introducing an organization to the unstructured point cloud before extracting information from airborne lidar data is common in many applications. Aggregating the points with similar features into segments in 3-D which comply with the nature of actual objects is affected by the neighborhood, scale, features and noise among other aspects. In this study, we present a min-cut based method for segmenting the point cloud. We first assess the neighborhood of each point in 3-D by investigating the local geometric and statistical properties of the candidates. Neighborhood selection is essential since point features are calculated within their local neighborhood. Following neighborhood determination, we calculate point features and determine the clusters in the feature space. We adapt a graph representation from image processing which is especially used in pixel labeling problems and establish it for the unstructured 3-D point clouds. The edges of the graph that are connecting the points with each other and nodes representing feature clusters hold the smoothness costs in the spatial domain and data costs in the feature domain. Smoothness costs ensure spatial coherence, while data costs control the consistency with the representative feature clusters. This graph representation formalizes the segmentation task as an energy minimization problem. It allows the implementation of an approximate solution by min-cuts for a global minimum of this NP hard minimization problem in low order polynomial time. We test our method with airborne lidar point cloud acquired with maximum planned post spacing of 1.4 m and a vertical accuracy 10.5 cm as RMSE. We present the effects of neighborhood and feature determination in the segmentation results and assess the accuracy and efficiency of the implemented min-cut algorithm as well as its sensitivity to the parameters of the smoothness and data cost functions. We find that smoothness cost that only considers simple distance

  20. Min-max optimal public service system design

    Directory of Open Access Journals (Sweden)

    Marek Kvet

    2015-03-01

    Full Text Available This paper deals with designing a fair public service system. To achieve fairness, various schemes are be applied. The strongest criterion in the process is minimization of disutility of the worst situated users and then optimization of disutility of the better situated users under the condition that disutility of the worst situated users does not worsen, otherwise called lexicographical minimization. Focusing on the first step, this paper endeavours to find an effective solution to the weighted p-median problem based on radial formulation. Attempts at solving real instances when using a location-allocation model often fail due to enormous computational time or huge memory demands. Radial formulation can be implemented using commercial optimisation software. The main goal of this study is to show that the suitability solving of the min-max optimal public service system design can save computational time.

  1. Lainsuojattomuudesta sukupuolineutraaliin avioliittoon – seksuaalivähemmistöjen aseman kehitys lainsäädännössä

    OpenAIRE

    Martikainen, Minna

    2016-01-01

    Tässä opinnäytetyössä tutkitaan, miten seksuaalivähemmistöjen asema Suomessa on kehittynyt lainsäädännössä varhaismodernista ajasta lähtien. Tutkimuskysymystä lähestytään lainopillisesta, oikeushistoriallisesta ja oikeussosiologisesta näkökulmasta. Opinnäytetyössä huomioidaan lakimuutosten lisäksi näin ollen myös evankelis-luterilaisen kirkon ja muiden yhteiskunnan asenteita muokkaavien tahojen sekä myös lääketieteen näkemykset. Opinnäytetyö on jaettu kolmeen päälukuun, jotka on sijoitett...

  2. Il mito di Ulisse nel romanzo del secondo Novecento: il tragico e l’antitragico in Stefano D’Arrigo e Walter Jens

    Directory of Open Access Journals (Sweden)

    Nora Moll

    2017-11-01

    Full Text Available In Twentieth Century’s Literature, the various declinations and rewritings of the Odysseus’ theme were conducted both in the tragic and the anti-tragic mode: the latter involving often, but not necessarily, the use of narrative strategies of parody. Referring to Hans Blumenberg (1979, we can speak of a constant “work on myth” that goes hand in hand with the development of postmodern poetics and elaboration of history, characterized by different narrative styles and strategies depending on the literary and cultural context in which they are inserted. Starting from one of the main theories about literary rewriting, as well as about mythopoetic and mythocritical discourse in twentieth century, this article aims to examine in a comparative perspective two novels, conceived almost at the same time in the Fifties, even if published separated by a distance of years. This is the "Mediterranean" novel Hocynus Orca (1975, by the Sicilian Stefano D'Arrigo, and Das Testament des Odysseus (1957, by the German writer Walter Jens, who is also known for his theoretical work on Greek mythology and tragedy. In these novels both authors choose the odyssean hypotext for liaising with the difficult legacy of World War II, but also to express its positioning in the contemporary world. The need to "complete" (Blumenberg the myth of Ulysses thus produces in D'Arrigo a reinterpretation of the novel in the epic and tragic way, while Jens escapes to the anti-tragic modus offering to its anti-hero a secondary way out from his own myth.

  3. The energetics of semicontact 3 x 2-min amateur boxing.

    Science.gov (United States)

    Davis, Philip; Leithäuser, Renate M; Beneke, Ralph

    2014-03-01

    The energy expenditure of amateur boxing is unknown. Total metabolic cost (Wtot) as an aggregate of aerobic (Waer), anaerobic lactic (W[lactate]), and anaerobic alactic (WPCr) energy of a 3 × 2-min semicontact amateur boxing bout was analyzed. Ten boxers (mean ± SD [lower/upper 95% confidence intervals]) age 23.7 ± 4.1 (20.8/26.6) y, height 180.2 ± 7.0 (175.2/185.2) cm, body mass 70.6 ± 5.7 (66.5/74.7) kg performed a semicontact bout against handheld pads created from previously analyzed video footage of competitive bouts. Net metabolic energy was calculated using respiratory gases and blood [lactate]. Waer, 526.0 ± 57.1 (485.1/566.9) kJ, was higher (P boxing is predominantly aerobic. They also highlight the importance of a highly developed aerobic capacity as a prerequisite of a high activity rate during rounds and recovery of the high-energy phosphate system during breaks as interrelated requirements of successful boxing.

  4. Dissecting the role of conformational change and membrane binding by the bacterial cell division regulator MinE in the stimulation of MinD ATPase activity.

    Science.gov (United States)

    Ayed, Saud H; Cloutier, Adam D; McLeod, Laura J; Foo, Alexander C Y; Damry, Adam M; Goto, Natalie K

    2017-12-15

    The bacterial cell division regulators MinD and MinE together with the division inhibitor MinC localize to the membrane in concentrated zones undergoing coordinated pole-to-pole oscillation to help ensure that the cytokinetic division septum forms only at the mid-cell position. This dynamic localization is driven by MinD-catalyzed ATP hydrolysis, stimulated by interactions with MinE's anti-MinCD domain. This domain is buried in the 6-β-stranded MinE "closed" structure, but is liberated for interactions with MinD, giving rise to a 4-β-stranded "open" structure through an unknown mechanism. Here we show that MinE-membrane interactions induce a structural change into a state resembling the open conformation. However, MinE mutants lacking the MinE membrane-targeting sequence stimulated higher ATP hydrolysis rates than the full-length protein, indicating that binding to MinD is sufficient to trigger this conformational transition in MinE. In contrast, conformational change between the open and closed states did not affect stimulation of ATP hydrolysis rates in the absence of membrane binding, although the MinD-binding residue Ile-25 is critical for this conformational transition. We therefore propose an updated model where MinE is brought to the membrane through interactions with MinD. After stimulation of ATP hydrolysis, MinE remains bound to the membrane in a state that does not catalyze additional rounds of ATP hydrolysis. Although the molecular basis for this inhibited state is unknown, previous observations of higher-order MinE self-association may explain this inhibition. Overall, our findings have general implications for Min protein oscillation cycles, including those that regulate cell division in bacterial pathogens. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  5. Alte und neue Problemaspekte der Figur. Zu einem medienübergreifenden Versuch einer Begriffsbestimmung der Figur [Jens Eder / Fotis Jannidis / Ralf Schneider (Hg.: Characters in Fic­tional Worlds. Understanding Imaginary Beings in Literature, Film, and Other Media. Berlin 2010

    Directory of Open Access Journals (Sweden)

    Carmen Lăcan

    2012-12-01

    Full Text Available Rezension zu / Review of:Jens Eder / Fotis Jannidis / Ralf Schneider (Hg.: Characters in Fic­tional Worlds. Understanding Imaginary Beings in Literature, Film, and Other Media. Berlin 2010

  6. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 2017; Session "Neonatal Fetal Nutrition and Metabolism"

    OpenAIRE

    --- Various Authors

    2017-01-01

    Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR), European Society for Neonatology (ESN), Union of European Neonatal & Perinatal Societies (UENPS), European Foundation for the Care of Newborn Infants (EFCNI)ORGANIZING COMMITTEELuc Zimmer...

  7. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 2017; Session "Neonatal Pulmonology, Neonatal Respiratory Support, Resuscitation"

    OpenAIRE

    --- Various Authors

    2017-01-01

    Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR), European Society for Neonatology (ESN), Union of European Neonatal & Perinatal Societies (UENPS), European Foundation for the Care of Newborn Infants (EFCNI)ORGANIZING COMMITTEELuc Zimmermann...

  8. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 2017; Session "Neurology and Follow-up"

    OpenAIRE

    --- Various Authors

    2017-01-01

    Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR), European Society for Neonatology (ESN), Union of European Neonatal & Perinatal Societies (UENPS), European Foundation for the Care of Newborn Infants (EFCNI)ORGANIZING COMMITTEELuc Zimmer...

  9. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 2017; Session "Quality Improvement, Parents Centered Care"

    OpenAIRE

    --- Various Authors

    2017-01-01

    Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR), European Society for Neonatology (ESN), Union of European Neonatal & Perinatal Societies (UENPS), European Foundation for the Care of Newborn Infants (EFCNI)ORGANIZING COMMITTEELuc Zi...

  10. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 2017; Session "Neonatal Infectious Diseases/Immunology"

    OpenAIRE

    --- Various Authors

    2017-01-01

    Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR), European Society for Neonatology (ESN), Union of European Neonatal & Perinatal Societies (UENPS), European Foundation for the Care of Newborn Infants (EFCNI)ORGANIZING COMMITTEELuc Zimmer...

  11. Jens Esmark's Christiania (Oslo) meteorological observations 1816-1838: the first long-term continuous temperature record from the Norwegian capital homogenized and analysed

    Science.gov (United States)

    Hestmark, Geir; Nordli, Øyvind

    2016-11-01

    In 2010 we rediscovered the complete set of meteorological observation protocols made by Jens Esmark (1762-1839) during his years of residence in the Norwegian capital of Oslo (then Christiania). From 1 January 1816 to 25 January 1839, Esmark at his house in Øvre Voldgate in the morning, early afternoon and late evening recorded air temperature with state-of-the-art thermometers. He also noted air pressure, cloud cover, precipitation and wind directions, and experimented with rain gauges and hygrometers. From 1818 to the end of 1838 he twice a month provided weather tables to the official newspaper Den Norske Rigstidende, and thus acquired a semi-official status as the first Norwegian state meteorologist. This paper evaluates the quality of Esmark's temperature observations and presents new metadata, new homogenization and analysis of monthly means. Three significant shifts in the measurement series were detected, and suitable corrections are proposed. The air temperature in Oslo during this period is shown to exhibit a slow rise from 1816 towards 1825, followed by a slighter fall again towards 1838.

  12. Septal membrane localization by C-terminal amphipathic α-helices of MinD in Bacillus subtilis mutant cells lacking MinJ or DivIVA.

    Science.gov (United States)

    Ishikawa, Kazuki; Matsuoka, Satoshi; Hara, Hiroshi; Matsumoto, Kouji

    2017-10-18

    The Min system, which inhibits assembly of the cytokinetic protein FtsZ, is largely responsible for positioning the division site in rod-shaped bacteria. It has been reported that MinJ, which bridges DivIVA and MinD, is targeted to the cell poles by an interaction with DivIVA, and that MinJ in turn recruits MinCD to the cell poles. MinC, however, is located primarily at active division sites at mid-cell when expressed from its native promoter. Surprisingly, we found that Bacillus subtilis MinD is located at nascent septal membranes and at an asymmetric site on lateral membranes between nascent septal membranes in filamentous cells lacking MinJ or DivIVA. Bacillus subtilis MinD has two amphipathic α-helices rich in basic amino acid residues at its C-terminus; one of these, named MTS1 here, is the counterpart of the membrane targeting sequence (MTS) in Escherichia coli MinD while the other, named MTS-like sequence (MTSL), is the nearest helix to MTS1. These amphipathic helices were located independently at nascent septal membranes in cells lacking MinJ or DivIVA, whereas elimination of the helices from the wild type protein reduced its localization considerably. MinD variants with altered MTS1 and MTSL, in which basic amino acid residues were replaced with proline or acidic residues, were not located at nascent septal membranes, indicating that the binding to the nascent septal membranes requires basic residues and a helical structure. The septal localization of MTSL, but not of MTS1, was dependent on host cell MinD. These results suggest that MinD is targeted to nascent septal membranes via its C-terminal amphipathic α-helices in B. subtilis cells lacking MinJ or DivIVA. Moreover, the diffuse distribution of MinD lacking both MTSs suggests that only a small fraction of MinD depends on MinJ for its localization to nascent septal membranes.

  13. Detection of active bile leak with Gd-EOB-DTPA enhanced MR cholangiography: Comparison of 20–25 min delayed and 60–180 min delayed images

    International Nuclear Information System (INIS)

    Cieszanowski, Andrzej; Stadnik, Anna; Lezak, Aleksandra; Maj, Edyta; Zieniewicz, Krzysztof; Rowinska-Berman, Katarzyna; Grudzinski, Ireneusz P.; Krawczyk, Marek; Rowiński, Olgierd

    2013-01-01

    Objectives: The purpose of this study was to assess the value of contrast-enhanced magnetic resonance cholangiography (MRC) performed in different time delays after injection of gadoxetic acid disodium (Gd-EOB-DTPA) for the diagnosis of active bile leak. Methods: This retrospective analysis included Gd-EOB-DTPA enhanced MR images of 34 patients suspected of bile leak. Images were acquired 20–25 min after Gd-EOB-DTPA injection. If there was inadequate contrast in the bile ducts then delayed images after 60–90 min and 150–180 min were obtained. Results were correlated with intraoperative findings, ERCP results, clinical data, laboratory tests, and follow-up examinations. Results: Gd-EOB-DTPA enhanced MRC yielded an overall sensitivity of 96.4%, specificity of 100% and accuracy of 97.1% for the diagnosis of an active bile leak. The sensitivity of 20–25 min delayed MR images was 42.9%, of combined 20–25 min and 60–90 min delayed images was 92.9% and of combined 20–25 min, 60–90 min and 150–180 min delayed images was 96.4%. Conclusions: Gd-EOB-DTPA enhanced MRC utilizing delayed phase images was effective for detecting the presence and location of active bile leaks. The images acquired 60–180 min post-injection enabled identification of bile leaks even in patients with a dilated biliary system or moderate liver dysfunction

  14. Maintenance of the cell morphology by MinC in Helicobacter pylori.

    Directory of Open Access Journals (Sweden)

    Pei-Yu Chiou

    Full Text Available In the model organism Escherichia coli, Min proteins are involved in regulating the division of septa formation. The computational genome analysis of Helicobacter pylori, a gram-negative microaerophilic bacterium causing gastritis and peptic ulceration, also identified MinC, MinD, and MinE. However, MinC (HP1053 shares a low identity with those of other bacteria and its function in H. pylori remains unclear. In this study, we used morphological and genetic approaches to examine the molecular role of MinC. The results were shown that an H. pylori mutant lacking MinC forms filamentous cells, while the wild-type strain retains the shape of short rods. In addition, a minC mutant regains the short rods when complemented with an intact minCHp gene. The overexpression of MinCHp in E. coli did not affect the growth and cell morphology. Immunofluorescence microscopy revealed that MinCHp forms helix-form structures in H. pylori, whereas MinCHp localizes at cell poles and pole of new daughter cell in E. coli. In addition, co-immunoprecipitation showed MinC can interact with MinD but not with FtsZ during mid-exponential stage of H. pylori. Altogether, our results show that MinCHp plays a key role in maintaining proper cell morphology and its function differs from those of MinCEc.

  15. Polymerization and oscillation stuttering in a filamentous model of the subcellular Min oscillation

    Science.gov (United States)

    Rutenberg, Andrew; Sengupta, Supratim; Sain, Anirban; Derr, Julien

    2011-03-01

    We present a computational model of the E. coli Min oscillation that involves polymerization of MinD filaments followed by depolymerization stimulated by filament-end zones of MinE. Our stochastic model is fully three-dimensional, and tracks the diffusion and interactions of every MinD and MinE molecule. We recover self-organized Min oscillations. We investigate the experimental phenomenon of oscillation stuttering, which we relate to the disruption of MinE tip-binding at the filament scale.

  16. Min mentor er min voksenven

    DEFF Research Database (Denmark)

    Kaiser, Birte

    2009-01-01

    En artikel i bogen: 6 belysninger af vejledning, brydninger, forståelser & praksis. Artiklen er et sammendrag af en diskursanalyse fra 2008 fra projetrapporten: Ind under huden, www.vejledning.net...

  17. Interdependency of formation and localisation of the Min complex controls symmetric plastid division.

    Science.gov (United States)

    Maple, Jodi; Møller, Simon G

    2007-10-01

    Plastid division represents a fundamental biological process essential for plant development; however, the molecular basis of symmetric plastid division is unclear. AtMinE1 plays a pivotal role in selection of the plastid division site in concert with AtMinD1. AtMinE1 localises to discrete foci in chloroplasts and interacts with AtMinD1, which shows a similar localisation pattern. Here, we investigate the importance of Min protein complex formation during the chloroplast division process. Dissection of the assembly of the Min protein complex and determination of the interdependency of complex assembly and localisation in planta allow us to present a model of the molecular basis of selection of the division site in plastids. Moreover, functional analysis of AtMinE1 in bacteria demonstrates the level of functional conservation and divergence of the plastidic MinE proteins.

  18. Mechanistic insights of the Min oscillator via cell-free reconstitution and imaging

    Science.gov (United States)

    Mizuuchi, Kiyoshi; Vecchiarelli, Anthony G.

    2018-05-01

    The MinD and MinE proteins of Escherichia coli self-organize into a standing-wave oscillator on the membrane to help align division at mid-cell. When unleashed from cellular confines, MinD and MinE form a spectrum of patterns on artificial bilayers—static amoebas, traveling waves, traveling mushrooms, and bursts with standing-wave dynamics. We recently focused our cell-free studies on bursts because their dynamics recapitulate many features of Min oscillation observed in vivo. The data unveiled a patterning mechanism largely governed by MinE regulation of MinD interaction with membrane. We proposed that the MinD to MinE ratio on the membrane acts as a toggle switch between MinE-stimulated recruitment and release of MinD from the membrane. In this review, we summarize cell-free data on the Min system and expand upon a molecular mechanism that provides a biochemical explanation as to how these two ‘simple’ proteins can form the remarkable spectrum of patterns.

  19. Quantum key distribution with finite resources: calculating the min-entropy

    Energy Technology Data Exchange (ETDEWEB)

    Bratzik, Sylvia; Mertz, Markus; Kampermann, Hermann; Abruzzo, Silvestre; Bruss, Dagmar [Heinrich-Heine-Universitaet, Duesseldorf (Germany)

    2010-07-01

    The min-entropy is an important quantity in quantum key distribution. Recently, a connection between the min- entropy and the minimal-error discrimination problem was found. We use this connection to evaluate the min-entropy for different quantum key distribution setups.

  20. The Role of the Petite Bourgeoisie within Capitalism: A Response to Pyong Gap Min.

    Science.gov (United States)

    Bonacich, Edna

    1989-01-01

    Presents an argument against Pyong Gap Min's interpretations of the author's views on Korean immigrant entrepreneurship in Los Angeles (California). Addresses the issues of empirical accuracy and policy implications that Min criticized. Discusses differences between Min's approach to social knowledge and her own. (JS)

  1. Modelování průtoků a vybraných parametrů jakosti vod na povodí Jenínského potoka modelem SWAT

    OpenAIRE

    HOMOLKA, Jan

    2014-01-01

    The thesis continues with the bachelor thesis which had dealt with preparation bases for simulation draining and carrying materials in SWAT model. Simulation should have been realized within basin of the Jenín stream, which watershed is 4,65 km2 large. SWAT model is primary developed for the larger watersheds where simulated values doesn't attain tolerances. Because of this is thesis focused on the methodic of simulation itself, discussion of the problem when is SWAT model almost useless for ...

  2. Stuttering Min oscillations within E. coli bacteria: a stochastic polymerization model

    International Nuclear Information System (INIS)

    Sengupta, Supratim; Derr, Julien; Sain, Anirban; Rutenberg, Andrew D

    2012-01-01

    We have developed a 3D off-lattice stochastic polymerization model to study the subcellular oscillation of Min proteins in the bacteria Escherichia coli, and used it to investigate the experimental phenomenon of Min oscillation stuttering. Stuttering was affected by the rate of immediate rebinding of MinE released from depolymerizing filament tips (processivity), protection of depolymerizing filament tips from MinD binding and fragmentation of MinD filaments due to MinE. Processivity, protection and fragmentation each reduce stuttering, speed oscillations and MinD filament lengths. Neither processivity nor tip protection were, on their own, sufficient to produce fast stutter-free oscillations. While filament fragmentation could, on its own, lead to fast oscillations with infrequent stuttering; high levels of fragmentation degraded oscillations. The infrequent stuttering observed in standard Min oscillations is consistent with short filaments of MinD, while we expect that mutants that exhibit higher stuttering frequencies will exhibit longer MinD filaments. Increased stuttering rate may be a useful diagnostic to find observable MinD polymerization under experimental conditions. (paper)

  3. Stuttering Min oscillations within E. coli bacteria: a stochastic polymerization model

    Science.gov (United States)

    Sengupta, Supratim; Derr, Julien; Sain, Anirban; Rutenberg, Andrew D.

    2012-10-01

    We have developed a 3D off-lattice stochastic polymerization model to study the subcellular oscillation of Min proteins in the bacteria Escherichia coli, and used it to investigate the experimental phenomenon of Min oscillation stuttering. Stuttering was affected by the rate of immediate rebinding of MinE released from depolymerizing filament tips (processivity), protection of depolymerizing filament tips from MinD binding and fragmentation of MinD filaments due to MinE. Processivity, protection and fragmentation each reduce stuttering, speed oscillations and MinD filament lengths. Neither processivity nor tip protection were, on their own, sufficient to produce fast stutter-free oscillations. While filament fragmentation could, on its own, lead to fast oscillations with infrequent stuttering; high levels of fragmentation degraded oscillations. The infrequent stuttering observed in standard Min oscillations is consistent with short filaments of MinD, while we expect that mutants that exhibit higher stuttering frequencies will exhibit longer MinD filaments. Increased stuttering rate may be a useful diagnostic to find observable MinD polymerization under experimental conditions.

  4. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Ethics"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Ethics"ABS 1. THE DELIVERY OF BAD NEWS: A ONE OR 2-STEP APPROACH? THE CASE FOR TRISOMY 21 • M.S. Schimmel, M.Y. Kassirer, H.M. TowersABS 2. NEONATAL ORGAN DONATION: A POTENTIAL NEW DONOR SOURCE FOR CELL AND ORGAN TRANSPLANTATION • C. Jorns, E. Henckel, G. Nowak, A. Karadagi, T. Kjellin, E. Bluhme, Ö. Jynge, M. Hending, A. Croon, M. Söderström, B. Fischler, A. Nemeth, R. Gramignoli, S. Strom, E. Ellis, B. HallbergABS 3. HEALTH CARE PROFESSIONALS’ AND PARENTS’ ATTITUDES TOWARD PARENTAL AUTONOMY AND THE BEST INTEREST OF THE EXTREME PRETERM INFANT: A NATIONAL STUDY IN SWITZERLAND • M. Hendriks, H. Bucher, S. Klein, R. Baumann-Holzle, J. Streuli, J. FauchèreABS 4. CHANGING PARENTAL PERCEPTIONS IN TRISOMIES – A POTENTIAL ETHICAL DILEMMA FOR NEONATOLOGISTS? • E. Simons, P. Nath, P. ParthasarathyABS 5. INGEBORG SYLLM-RAPOPORT (1912-2017 – AN EXEMPLARY LIFE FOR CHILDREN AND PAEDIATRICS • H. Sallmon, R.R. Wauer, C.C. RoehrABS 6. RETROSPECTIVE ANALYSES OF PARENTAL COUNSELING AND DECISION MAKING FOR EXTREME PRETERM BIRTH IN A TERTIARY DUTCH PERINATAL CENTER • E. de Booij, J

  5. AREVA announces US$ 7.75 Per share friendly cash offer for UraMin

    International Nuclear Information System (INIS)

    2007-01-01

    AREVA and UraMin Inc. ('UraMin') entered on June 15, 2007 into an agreement in respect of AREVA's friendly cash offer for 100% of the share capital of UraMin. UraMin is listed in London (AIM) and Toronto (TSX). AREVA (Euronext Paris) already owns 5.5% of UraMin's share capital. This cash offer of AREVA will be made through its indirect wholly-owned subsidiary CFMM Development ('AREVA') based on a price of US$ 7.75 per UraMin share. The total offer consideration amounts to more than USD 2.5 billion for 100% of the fully diluted share capital of UraMin. This represents a premium of 21% over UraMin 20-day weighted average trading price ending on June 8, 2007. The UraMin Board of Directors, after consulting with its financial advisors, has determined that the offer is fair and in the best interest of the UraMin shareholders and it has resolved to recommend acceptance of the Offer. BMO Capital Markets has provided an opinion that the offer is fair, from a financial point of view, to the UraMin shareholders. In connection with the offer, all directors and certain other shareholders representing approximately 25% of the outstanding UraMin shares (calculated on a fully diluted basis) have entered into lock-up agreements with AREVA pursuant to which they have agreed to tender all their UraMin shares to AREVA's offer. The support agreement entered into between AREVA and UraMin provides for, among other things, in case a superior proposal is accepted by UraMin, a right to match in favour of AREVA. The support agreement also includes a break up fee in favour of AREVA of US$ 75 million under certain circumstances. Concurrently with the closing of the proposed offer, UraMin will declare a dividend payable in shares of the capital of Niger Uranium Limited held by UraMin (where permitted by law) or a cash equivalent of the value of such shares

  6. Rapid and Accurate Sequencing of Enterovirus Genomes Using MinION Nanopore Sequencer.

    Science.gov (United States)

    Wang, Ji; Ke, Yue Hua; Zhang, Yong; Huang, Ke Qiang; Wang, Lei; Shen, Xin Xin; Dong, Xiao Ping; Xu, Wen Bo; Ma, Xue Jun

    2017-10-01

    Knowledge of an enterovirus genome sequence is very important in epidemiological investigation to identify transmission patterns and ascertain the extent of an outbreak. The MinION sequencer is increasingly used to sequence various viral pathogens in many clinical situations because of its long reads, portability, real-time accessibility of sequenced data, and very low initial costs. However, information is lacking on MinION sequencing of enterovirus genomes. In this proof-of-concept study using Enterovirus 71 (EV71) and Coxsackievirus A16 (CA16) strains as examples, we established an amplicon-based whole genome sequencing method using MinION. We explored the accuracy, minimum sequencing time, discrimination and high-throughput sequencing ability of MinION, and compared its performance with Sanger sequencing. Within the first minute (min) of sequencing, the accuracy of MinION was 98.5% for the single EV71 strain and 94.12%-97.33% for 10 genetically-related CA16 strains. In as little as 14 min, 99% identity was reached for the single EV71 strain, and in 17 min (on average), 99% identity was achieved for 10 CA16 strains in a single run. MinION is suitable for whole genome sequencing of enteroviruses with sufficient accuracy and fine discrimination and has the potential as a fast, reliable and convenient method for routine use. Copyright © 2017 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.

  7. Radiation-induced intestinal neoplasia in a genetically-predisposed mouse (Min)

    International Nuclear Information System (INIS)

    Ellender, M.; Larder, S.M.; Harrison, J.D.; Cox, R.; Silver, A.R.J.

    1997-01-01

    A mouse lineage with inherited predisposition to multiple intestinal neoplasia (min) has been proposed as a model to study human colorectal cancer. Min mice are heterozygous for the adenomatous polyposis coli (Apc) gene implicated in human familial adenomatous polyposis (FAP). There is an increased risk of intestinal cancer in humans following radiation exposure and the min mouse model may be used to further our understanding of the molecular mechanisms involved. The present study showed a 2 Gy dose of x-rays doubles the tumour numbers in the murine gastrointestinal tract of F1 min heterozygotes. The distribution of tumours through the gut was also recorded. (authors)

  8. The development of a differential game related to terrorism: Min-Max differential game

    Directory of Open Access Journals (Sweden)

    Abd El-Monem A. Megahed

    2017-07-01

    Full Text Available In this work, we study a differential game related to terrorism: Min-Max differential game taking into account the governmental activities such as the education quality, increasing the chances of labor, social justice, religious awareness and security arrangements. A Min-Max differential game between government and terrorist organizations is considered in this study. To obtain the optimal strategy of solving this problem, we study the analytic form of a Min-Max differential game and the governmental activities. Furthermore, a saddle point of a Min-Max differential game is studied.

  9. Genetic and Biochemical Characterization of the MinC-FtsZ Interaction in Bacillus subtilis

    Science.gov (United States)

    Castellen, Patricia; Nogueira, Maria Luiza C.; Bettini, Jefferson; Portugal, Rodrigo V.; Zeri, Ana Carolina M.; Gueiros-Filho, Frederico J.

    2013-01-01

    Cell division in bacteria is regulated by proteins that interact with FtsZ and modulate its ability to polymerize into the Z ring structure. The best studied of these regulators is MinC, an inhibitor of FtsZ polymerization that plays a crucial role in the spatial control of Z ring formation. Recent work established that E. coli MinC interacts with two regions of FtsZ, the bottom face of the H10 helix and the extreme C-terminal peptide (CTP). Here we determined the binding site for MinC on Bacillus subtilis FtsZ. Selection of a library of FtsZ mutants for survival in the presence of Min overexpression resulted in the isolation of 13 Min-resistant mutants. Most of the substitutions that gave rise to Min resistance clustered around the H9 and H10 helices in the C-terminal domain of FtsZ. In addition, a mutation in the CTP of B. subtilis FtsZ also produced MinC resistance. Biochemical characterization of some of the mutant proteins showed that they exhibited normal polymerization properties but reduced interaction with MinC, as expected for binding site mutations. Thus, our study shows that the overall architecture of the MinC-FtsZ interaction is conserved in E. coli and B. subtilis. Nevertheless, there was a clear difference in the mutations that conferred Min resistance, with those in B. subtilis FtsZ pointing to the side of the molecule rather than to its polymerization interface. This observation suggests that the mechanism of Z ring inhibition by MinC differs in both species. PMID:23577149

  10. Reliability of the 6-min walk test after total knee arthroplasty

    DEFF Research Database (Denmark)

    Jakobsen, Thomas Linding; Kehlet, Henrik; Bandholm, Thomas

    2013-01-01

    PURPOSE: The 6-min walk test is a simple clinical outcome measure, which has been used frequently to assess functional performance in many different patient groups, including patients with total knee arthroplasty (TKA). The 6-min walk test measures the maximal distance a subject is able to walk i...

  11. Characterization of ftsZ mutations that render Bacillus subtilis resistant to MinC

    NARCIS (Netherlands)

    de Oliveira, I.F.F.; Sousa Borges, A.; Kooij, V.; Bartosiak-Jentys, J.; Luirink, S.; Scheffers, D.J.

    2010-01-01

    Background: Cell division in Bacillus subtilis occurs precisely at midcell. Positional control of cell division is exerted by two mechanisms: nucleoid occlusion, through Noc, which prevents division through nucleoids, and the Min system, where the combined action of the MinC, D and J proteins

  12. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Perinatal Pharmacology and Anesthesia"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Perinatal Pharmacology and Anesthesia"ABS 1. UNDERSTANDING THE RELATIONSHIP BETWEEN DOPAMINE CONCENTRATION AND BLOOD PRESSURE IN NEONATES: INCUBATORS VERSUS COT • K. Kirupakaran, H. Rabe, B. PatelABS 2. IBUPROFEN PHARMACOGENETIC STUDY IN HUMAN MILK SAMPLES • V. Rigourd, C. Verstyuft, J.F. Méritet, P. Seraissol, B. De Villepin, A. Amirouche, R. SerreauABS 3. EFFECT OF POSTNATAL CORTICOSTEROID ON BROWN ADIPOSE TISSUE THERMOGENESIS IN NEONATAL RAT • Y.-S. Chang, C.-H. Lin, Y.-S. TsaiABS 4. URINARY 17-α-HYDROXY-PROGESTERONE AS A POTENTIAL MARKER OF NEONATAL PAIN • M. Brasseler, T. HoehnABS 5. PHARMACOKINETIC AND PHARMACODYNAMIC STUDIES AIMING FOR RATIONAL DRUG DOSING IN PRETERM NEONATES: THE DINO STUDY • R.B. Flint, S. Völler, R. de Groot, D. Liem, P. Andriessen, P. Degrauewe, I. Reiss, D. Burger, D. Tibboel, C.A.J. Knibbe, S.H.P. Simons and DINO Research groupABS 6. VENO-ARTERIAL EXTRACORPOREAL MEM­BRANE OXYGENATION IMPAIRS ACETYL­CHOLINE-INDUCED CONTRACTION IN NEONATAL PORCINE CORONARY ARTERIES • L. Provitera, G. Cavallaro, G. Raffaeli, I. Amodeo, S. Gulden, G. Zuanetti, V

  13. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Perinatal Practices"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Perinatal Practices"ABS 1. VACUUM EXTRACTION AND RISK OF NEONATAL COMPLICATIONS: A POPULATION-BASED COHORT STUDY • D. Rossetti, A.S. Laganà, G. Valenti, B. Chiofalo, S. Butticè, G. Sanpietro, A.M.C. Rapisarda, F. Sapia, M. Noventa, A. Vitagliano, S.G. VitaleABS 2. ELECTIVE CAESAREAN SECTION AND RES­PIRATORY MORBIDITIES IN TERM INFANTS • P. Mallya, S. GargABS 3. RISK FACTORS AND OUTCOME IN PRE­VIABLE PPROM AND CURRENT TREATMENT PRACTICE • A. van Gennip, E.E.M. Mulder, R.M. Brohet, J. van Eyck, R.A. van LingenABS 4. ASSESSMENT OF FUNCTIONAL STATUS IN PRETERM INFANTS: ONLINE SURVEY TO INFORM SCORING OF A CLINICIAN-REPORTED OUTCOMES (CLINRO TOOL • M. Turner, I. Hansen-Pupp, J. Higginson, R. Ward, M. Vanya, E. Flood, E. Schwartz, H. Doll, A. Tocoian, A. Mangili, N. Barton, S. SardaABS 5. INFANTS AND MATERNAL OUTCOME OF PREGNANCIES COMPLICATED BY H1N1 INFECTION NEEDING ECMO THERAPY: A UK ECMO CENTRE EXPERIENCE • N. Singh, J. Behrsin, F. Siddiqui, R. Porter, M. Charlton, A. Akuma, S. MittalABS 6. THE ASSOCIATION OF NEONATAL MORBIDITIES AND MORTALITY OF PRETERM INFANTS WITH

  14. The application of Max-Plus/Min-Plus algebra for an automated analysis; Einsatz der Max-Plus/Min-Plus Algebra zur automatisierten Sicherheitsanalyse

    Energy Technology Data Exchange (ETDEWEB)

    Laengst, W.; Lapp, A.; Stuebbe, K.; Schirmer, J.; Kraft, D. [Robert Bosch GmbH, Stuttgart (Germany). Zentralbereich Forschung und Vorausentwicklung

    2003-07-01

    The methodology introduced in this article is capable of describing a binary behavior of distributed discrete event systems. This is the basis for a safety analysis in early phases of system development and for an automated determination of failure dependencies. For this purpose a system equation similar to the state-space representation in system theory is used. The equation is evaluated applying the Max-Plus/Min-Plus algebra. The procedure is exemplified by a simplified braking system. (orig.) [German] In dem vorliegenden Artikel wird ein Verfahren zur binaeren Beschreibung von verteilten ereignisdiskreten Systemen vorgestellt. Dieses wird als Grundlage fuer eine Sicherheitsanalyse in einer fruehen Phase der Systementwicklung und zur automatisierten Ermittlung von Fehlerabhaengigkeiten eingesetzt. Hierzu wird eine Systemgleichung verwendet, die aehnlich zu der Zustandsraumdarstellung der konventionellen Systemtheorie ist. Dabei erfolgt die Auswertung der Systemgleichung durch Anwendung der Max-Plus/Min-Plus Algebra. Die Vorgehensweise wird anhand des Beispiels eines vereinfachten Bremssystems erlaeutert. (orig.)

  15. Braking materials for emergency stop device of super high speed elevator (810 m/min); 810 m/min erebeta hijo tome sochiyo masatsuzai

    Energy Technology Data Exchange (ETDEWEB)

    Okada, R.; Yamada, T.; Sugahara, J. [Hitachi Ltd., Tokyo (Japan)

    1995-04-20

    Accompanied with a super multistoried building, making the elevator a higher speed is essential and it requires for a performance rise not only on drive unit and control unit, but also on safety device as well, as for especially an emergency stop device to get the cage, which has a kinetic energy proportional to the square of speed, stopped, its performance improvement is indispensable. Because it was anticipated that a braking would become difficult with a speed exceeding 800 m/min by using the iron system materials centering around cast iron used conventionally, an emergency stop device using the special ceramics as a friction material has been developed. In order to develop an elevator with a super high speed of 810 m/min this time, a development of the friction material for emergency stop device, which can brake stably the cage with a kinetic energy substantially exceeding the conventional value, has been advanced. As a result, a strength drop at a high temperature was prevented by adding Cr, Ni and P, and moreover a cast iron with 1,5 times in mean friction coefficient and about 1/10 in specific abrasive quantity compared with FC 250 was developed, and furthermore an emergency stop device with a high performance, which guarantees more than 3 times of braking energy in the emergency stop device of elevator with a speed of 540 m/min, was realized. 5 refs., 8 figs., 1 tab.

  16. Epithelial-derived IL-33 promotes intestinal tumorigenesis in Apc Min/+ mice.

    Science.gov (United States)

    He, Zhengxiang; Chen, Lili; Souto, Fabricio O; Canasto-Chibuque, Claudia; Bongers, Gerold; Deshpande, Madhura; Harpaz, Noam; Ko, Huaibin M; Kelley, Kevin; Furtado, Glaucia C; Lira, Sergio A

    2017-07-14

    Increased expression of Interleukin (IL)-33 has been detected in intestinal samples of patients with ulcerative colitis, a condition associated with increased risk for colon cancer, but its role in the development of colorectal cancer has yet to be fully examined. Here, we investigated the role of epithelial expressed IL-33 during development of intestinal tumors. IL-33 expression was detected in epithelial cells in colorectal cancer specimens and in the Apc Min/+ mice. To better understand the role of epithelial-derived IL-33 in the intestinal tumorigenesis, we generated transgenic mice expressing IL-33 in intestinal epithelial cells (V33 mice). V33 Apc Min/+ mice, resulting from the cross of V33 with Apc Min/+ mice, had increased intestinal tumor burden compared with littermate Apc Min/+ mice. Consistently, Apc Min/+ mice deficient for IL-33 receptor (ST2), had reduced polyp burden. Mechanistically, overexpression of IL-33 promoted expansion of ST2 + regulatory T cells, increased Th2 cytokine milieu, and induced alternatively activated macrophages in the gut. IL-33 promoted marked changes in the expression of antimicrobial peptides, and antibiotic treatment of V33 Apc Min/+ mice abrogated the tumor promoting-effects of IL-33 in the colon. In conclusion, elevated IL-33 signaling increases tumor development in the Apc Min/+ mice.

  17. Extensive metabolic disorders are present in APC(min) tumorigenesis mice.

    Science.gov (United States)

    Liu, Zhenzhen; Xiao, Yi; Zhou, Zhengxiang; Mao, Xiaoxiao; Cai, Jinxing; Xiong, Lu; Liao, Chaonan; Huang, Fulian; Liu, Zehao; Ali Sheikh, Md Sayed; Plutzky, Jorge; Huang, He; Yang, Tianlun; Duan, Qiong

    2016-05-15

    Wnt signaling plays essential role in mesenchymal stem cell (MSC) differentiation. Activation of Wnt signaling suppresses adipogenesis, but promotes osteogenesis in MSC. Adenomatous polyposis coli (APC) is a negative regulator of β-catenin and Wnt signaling activity. The mutation of APC gene leads to the activation of Wnt signaling and is responsible for tumorigenesis in APC(min) mouse; however, very few studies focused on its metabolic abnormalities. The present study reports a widespread metabolic disorder phenotype in APC(min) mice. The old APC(min) mice have decreased body weight and impaired adipogenesis, but severe hyperlipidemia, which mimic the phenotypes of Familial Adenomatous Polyposis (FAP), an inherited disease also caused by APC gene mutation in human. We found that the expression of lipid metabolism and free fat acids (FA) use genes in the white adipose tissue (WAT) of the APC(min) mice is much lower than those of control. The changed gene expression pattern may lead to the disability of circulatory lipid transportation and storage at WAT. Moreover, the APC(min) mice could not maintain the core body temperature in cold condition. PET-CT determination revealed that the BAT of APC(min) mice has significantly impaired ability to take up (18)FDG from the blood. Morphological studies identified that the brown adipocytes of APC(min) mice were filled with lipid droplets but fewer mitochondria. These results matched with the findings of impaired BAT function in APC(min) mice. Collectively, our study explores a new mechanism that explains abnormal metabolism in APC(min) mice and provides insights into studying the metabolic disorders of FAP patients. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  18. Study of 1-min rain rate integration statistic in South Korea

    Science.gov (United States)

    Shrestha, Sujan; Choi, Dong-You

    2017-03-01

    The design of millimeter wave communication links and the study of propagation impairments at higher frequencies due to a hydrometeor, particularly rain, require the knowledge of 1-min. rainfall rate data. Signal attenuation in space communication results are due to absorption and scattering of radio wave energy. Radio wave attenuation due to rain depends on the relevance of a 1-min. integration time for the rain rate. However, in practice, securing these data over a wide range of areas is difficult. Long term precipitation data are readily available. However, there is a need for a 1-min. rainfall rate in the rain attenuation prediction models for a better estimation of the attenuation. In this paper, we classify and survey the prominent 1-min. rain rate models. Regression analysis was performed for the study of cumulative rainfall data measured experimentally for a decade in nine different regions in South Korea, with 93 different locations, using the experimental 1-min. rainfall accumulation. To visualize the 1-min. rainfall rate applicable for the whole region for 0.01% of the time, we have considered the variation in the rain rate for 40 stations across South Korea. The Kriging interpolation method was used for spatial interpolation of the rain rate values for 0.01% of the time into a regular grid to obtain a highly consistent and predictable rainfall variation. The rain rate exceeded the 1-min. interval that was measured through the rain gauge compared to the rainfall data estimated using the International Telecommunication Union Radio Communication Sector model (ITU-R P.837-6) along with the empirical methods as Segal, Burgueno et al., Chebil and Rahman, logarithmic, exponential and global coefficients, second and third order polynomial fits, and Model 1 for Icheon regions under the regional and average coefficient set. The ITU-R P. 837-6 exhibits a lower relative error percentage of 3.32% and 12.59% in the 5- and 10-min. to 1-min. conversion, whereas the

  19. Breast MRI at very short TE (minTE). Image analysis of minTE sequences on non-fat-saturated, subtracted T1-weighted images

    International Nuclear Information System (INIS)

    Wenkel, Evelyn; Janka, Rolf; Kaemmerer, Nadine; Uder, Michael; Hammon, Matthias; Brand, Michael; Hartmann, Arndt

    2017-01-01

    The aim was to evaluate a minimum echo time (minTE) protocol for breast magnetic resonance imaging (MRI) in patients with breast lesions compared to a standard TE (nTE) time protocol. Breasts of 144 women were examined with a 1.5 Tesla MRI scanner. Additionally to the standard gradient-echo sequence with nTE (4.8 ms), a variant with minimum TE (1.2 ms) was used in an interleaved fashion which leads to a better temporal resolution and should reduce the scan time by approximately 50%. Lesion sizes were measured and the signal-to-noise ratio (SNR) as well as the contrast-to-noise ratio (CNR) were calculated. Subjective confidence was evaluated using a 3-point scale before looking at the nTE sequences (1 = very sure that I can identify a lesion and classify it, 2 = quite sure that I can identify a lesion and classify it, 3 = definitely want to see nTE for final assessment) and the subjective image quality of all examinations was evaluated using a four-grade scale (1 = sharp, 2 = slight blur, 3 = moderate blur and 4 = severe blur/not evaluable) for lesion and skin sharpness. Lesion morphology and contrast enhancement were also evaluated. With minTE sequences, no lesion was rated with ''definitely want to see nTE sequences for final assessment''. The difference of the longitudinal and transverse diameter did not differ significantly (p>0.05). With minTE, lesions and skin were rated to be significantly more blurry (p<0.01 for lesions and p<0.05 for skin). There was no difference between both sequences with respect to SNR, CNR, lesion morphology, contrast enhancement and detection of multifocal disease. Dynamic breast MRI with a minTE protocol is feasible without a major loss of information (SNR, CNR, lesion morphology, contrast enhancement and lesion sizes) and the temporal resolution can be increased by a factor of 2 using minTE sequences.

  20. Breast MRI at very short TE (minTE). Image analysis of minTE sequences on non-fat-saturated, subtracted T1-weighted images

    Energy Technology Data Exchange (ETDEWEB)

    Wenkel, Evelyn; Janka, Rolf; Kaemmerer, Nadine; Uder, Michael; Hammon, Matthias; Brand, Michael [Univ. Hospital Erlangen (Germany). Dept. of Radiology; Geppert, Christian [Siemens Healthcare GmbH, Erlangen (Germany); Hartmann, Arndt [Univ. Hospital Erlangen (Germany). Dept. of Pathology

    2017-02-15

    The aim was to evaluate a minimum echo time (minTE) protocol for breast magnetic resonance imaging (MRI) in patients with breast lesions compared to a standard TE (nTE) time protocol. Breasts of 144 women were examined with a 1.5 Tesla MRI scanner. Additionally to the standard gradient-echo sequence with nTE (4.8 ms), a variant with minimum TE (1.2 ms) was used in an interleaved fashion which leads to a better temporal resolution and should reduce the scan time by approximately 50%. Lesion sizes were measured and the signal-to-noise ratio (SNR) as well as the contrast-to-noise ratio (CNR) were calculated. Subjective confidence was evaluated using a 3-point scale before looking at the nTE sequences (1 = very sure that I can identify a lesion and classify it, 2 = quite sure that I can identify a lesion and classify it, 3 = definitely want to see nTE for final assessment) and the subjective image quality of all examinations was evaluated using a four-grade scale (1 = sharp, 2 = slight blur, 3 = moderate blur and 4 = severe blur/not evaluable) for lesion and skin sharpness. Lesion morphology and contrast enhancement were also evaluated. With minTE sequences, no lesion was rated with ''definitely want to see nTE sequences for final assessment''. The difference of the longitudinal and transverse diameter did not differ significantly (p>0.05). With minTE, lesions and skin were rated to be significantly more blurry (p<0.01 for lesions and p<0.05 for skin). There was no difference between both sequences with respect to SNR, CNR, lesion morphology, contrast enhancement and detection of multifocal disease. Dynamic breast MRI with a minTE protocol is feasible without a major loss of information (SNR, CNR, lesion morphology, contrast enhancement and lesion sizes) and the temporal resolution can be increased by a factor of 2 using minTE sequences.

  1. Asymptotic identity in min-plus algebra: a report on CPNS.

    Science.gov (United States)

    Li, Ming; Zhao, Wei

    2012-01-01

    Network calculus is a theory initiated primarily in computer communication networks, especially in the aspect of real-time communications, where min-plus algebra plays a role. Cyber-physical networking systems (CPNSs) are recently developing fast and models in data flows as well as systems in CPNS are, accordingly, greatly desired. Though min-plus algebra may be a promising tool to linearize any node in CPNS as can be seen from its applications to the Internet computing, there are tough problems remaining unsolved in this regard. The identity in min-plus algebra is one problem we shall address. We shall point out the confusions about the conventional identity in the min-plus algebra and present an analytical expression of the asymptotic identity that may not cause confusions.

  2. 2.5-min Isostatic Gravity Grid for the United States

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The 2.5-min isostatic gravity data set was produced by regridding the 4-km residual isostatic gravity grid of the U.S. The isostatic residual gravity grid was...

  3. Peculiarities of natural electromagnetic field variations in the interval of periods of 60-240 min

    International Nuclear Information System (INIS)

    Kovtun, A.A.; Smirnov, M.Yu.

    1996-01-01

    Intensification of the oscillation amplitude of the natural electromagnetic field within 60-240 min period interval at practically all the latitudes was observed during the Earth re-entry to plasma high-speed flow

  4. MODIS/Aqua Clouds 5-Min L2 Swath 1km and 5km V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The MODIS/Aqua Clouds 5-Min L2 Swath 1km and 5km (MYD06_L2) product consists of cloud optical and physical parameters. These parameters are derived using remotely...

  5. MODIS/Aqua Aerosol 5-Min L2 Swath 10km V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The MODIS/Aqua Aerosol 5-Min L2 Swath 10km (MYD04_L2) product continues to provide full global coverage of aerosol properties from the Dark Target (DT) and Deep Blue...

  6. Asymptotic Identity in Min-Plus Algebra: A Report on CPNS

    Science.gov (United States)

    Li, Ming; Zhao, Wei

    2012-01-01

    Network calculus is a theory initiated primarily in computer communication networks, especially in the aspect of real-time communications, where min-plus algebra plays a role. Cyber-physical networking systems (CPNSs) are recently developing fast and models in data flows as well as systems in CPNS are, accordingly, greatly desired. Though min-plus algebra may be a promising tool to linearize any node in CPNS as can be seen from its applications to the Internet computing, there are tough problems remaining unsolved in this regard. The identity in min-plus algebra is one problem we shall address. We shall point out the confusions about the conventional identity in the min-plus algebra and present an analytical expression of the asymptotic identity that may not cause confusions. PMID:21822446

  7. MODIS/Aqua Raw Radiances in Counts 5-Min L1A Swath V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The MODIS/Aqua Raw Radiances in Counts 5-Min L1A Swath (MYD01) product contains reformatted and packaged raw instrument data. MODIS instrument data, in packetized...

  8. Maxi-Min Language Use A Critical Remark on a Concept by Philippe van Parijs

    Directory of Open Access Journals (Sweden)

    Kruse Jan

    2016-10-01

    Full Text Available Philippe van Parijs explains in Linguistic Justice for Europe and for the World the concept of maxi-min language use as a process of language choice. He suggests that the language chosen as a common language should maximize the minimal competence of a community. Within a multilingual group of people, the chosen language is the language known best by a participant who knows it least. For obvious reasons, only English would qualify for having that status. This article argues that maxi-min is rather a normative concept, not only because the process itself remains empirically unfounded. Moreover, language choice is the result of complex social and psychological structures. As a descriptive process, the maxi-min choice happens in the reality fairly seldom, whereas the max-min use of languages seen as a normative process could be a very effective tool to measure linguistic justice.

  9. MSL Chemistry and Mineralogy X-Ray Diffraction X-Ray Fluorescence (CheMin) Instrument

    Science.gov (United States)

    Zimmerman, Wayne; Blake, Dave; Harris, William; Morookian, John Michael; Randall, Dave; Reder, Leonard J.; Sarrazin, Phillipe

    2013-01-01

    This paper provides an overview of the Mars Science Laboratory (MSL) Chemistry and Mineralogy Xray Diffraction (XRD), X-ray Fluorescence (XRF) (CheMin) Instrument, an element of the landed Curiosity rover payload, which landed on Mars in August of 2012. The scientific goal of the MSL mission is to explore and quantitatively assess regions in Gale Crater as a potential habitat for life - past or present. The CheMin instrument will receive Martian rock and soil samples from the MSL Sample Acquisition/Sample Processing and Handling (SA/SPaH) system, and process it utilizing X-Ray spectroscopy methods to determine mineral composition. The Chemin instrument will analyze Martian soil and rocks to enable scientists to investigate geophysical processes occurring on Mars. The CheMin science objectives and proposed surface operations are described along with the CheMin hardware with an emphasis on the system engineering challenges associated with developing such a complex instrument.

  10. Regulation of the Min Cell Division Inhibition Complex by the Rcs Phosphorelay in Proteus mirabilis.

    Science.gov (United States)

    Howery, Kristen E; Clemmer, Katy M; Şimşek, Emrah; Kim, Minsu; Rather, Philip N

    2015-08-01

    A key regulator of swarming in Proteus mirabilis is the Rcs phosphorelay, which represses flhDC, encoding the master flagellar regulator FlhD4C2. Mutants in rcsB, the response regulator in the Rcs phosphorelay, hyperswarm on solid agar and differentiate into swarmer cells in liquid, demonstrating that this system also influences the expression of genes central to differentiation. To gain a further understanding of RcsB-regulated genes involved in swarmer cell differentiation, transcriptome sequencing (RNA-Seq) was used to examine the RcsB regulon. Among the 133 genes identified, minC and minD, encoding cell division inhibitors, were identified as RcsB-activated genes. A third gene, minE, was shown to be part of an operon with minCD. To examine minCDE regulation, the min promoter was identified by 5' rapid amplification of cDNA ends (5'-RACE), and both transcriptional lacZ fusions and quantitative real-time reverse transcriptase (qRT) PCR were used to confirm that the minCDE operon was RcsB activated. Purified RcsB was capable of directly binding the minC promoter region. To determine the role of RcsB-mediated activation of minCDE in swarmer cell differentiation, a polar minC mutation was constructed. This mutant formed minicells during growth in liquid, produced shortened swarmer cells during differentiation, and exhibited decreased swarming motility. This work describes the regulation and role of the MinCDE cell division system in P. mirabilis swarming and swarmer cell elongation. Prior to this study, the mechanisms that inhibit cell division and allow swarmer cell elongation were unknown. In addition, this work outlines for the first time the RcsB regulon in P. mirabilis. Taken together, the data presented in this study begin to address how P. mirabilis elongates upon contact with a solid surface. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  11. Training the Recurrent neural network by the Fuzzy Min-Max algorithm for fault prediction

    International Nuclear Information System (INIS)

    Zemouri, Ryad; Racoceanu, Daniel; Zerhouni, Noureddine; Minca, Eugenia; Filip, Florin

    2009-01-01

    In this paper, we present a training technique of a Recurrent Radial Basis Function neural network for fault prediction. We use the Fuzzy Min-Max technique to initialize the k-center of the RRBF neural network. The k-means algorithm is then applied to calculate the centers that minimize the mean square error of the prediction task. The performances of the k-means algorithm are then boosted by the Fuzzy Min-Max technique.

  12. Kaiso overexpression promotes intestinal inflammation and potentiates intestinal tumorigenesis in Apc(Min/+) mice.

    Science.gov (United States)

    Pierre, Christina C; Longo, Joseph; Mavor, Meaghan; Milosavljevic, Snezana B; Chaudhary, Roopali; Gilbreath, Ebony; Yates, Clayton; Daniel, Juliet M

    2015-09-01

    Constitutive Wnt/β-catenin signaling is a key contributor to colorectal cancer (CRC). Although inactivation of the tumor suppressor adenomatous polyposis coli (APC) is recognized as an early event in CRC development, it is the accumulation of multiple subsequent oncogenic insults facilitates malignant transformation. One potential contributor to colorectal carcinogenesis is the POZ-ZF transcription factor Kaiso, whose depletion extends lifespan and delays polyp onset in the widely used Apc(Min/+) mouse model of intestinal cancer. These findings suggested that Kaiso potentiates intestinal tumorigenesis, but this was paradoxical as Kaiso was previously implicated as a negative regulator of Wnt/β-catenin signaling. To resolve Kaiso's role in intestinal tumorigenesis and canonical Wnt signaling, we generated a transgenic mouse model (Kaiso(Tg/+)) expressing an intestinal-specific myc-tagged Kaiso transgene. We then mated Kaiso(Tg/+) and Apc(Min/+) mice to generate Kaiso(Tg/+):Apc(Min/+) mice for further characterization. Kaiso(Tg/+):Apc(Min/+) mice exhibited reduced lifespan and increased polyp multiplicity compared to Apc(Min/+) mice. Consistent with this murine phenotype, we found increased Kaiso expression in human CRC tissue, supporting a role for Kaiso in human CRC. Interestingly, Wnt target gene expression was increased in Kaiso(Tg/+):Apc(Min/+) mice, suggesting that Kaiso's function as a negative regulator of canonical Wnt signaling, as seen in Xenopus, is not maintained in this context. Notably, Kaiso(Tg/+):Apc(Min/+) mice exhibited increased inflammation and activation of NFκB signaling compared to their Apc(Min/+) counterparts. This phenotype was consistent with our previous report that Kaiso(Tg/+) mice exhibit chronic intestinal inflammation. Together our findings highlight a role for Kaiso in promoting Wnt signaling, inflammation and tumorigenesis in the mammalian intestine. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. Global statistical maps of extreme-event magnetic observatory 1 min first differences in horizontal intensity

    Science.gov (United States)

    Love, Jeffrey J.; Coisson, Pierdavide; Pulkkinen, Antti

    2016-01-01

    Analysis is made of the long-term statistics of three different measures of ground level, storm time geomagnetic activity: instantaneous 1 min first differences in horizontal intensity ΔBh, the root-mean-square of 10 consecutive 1 min differences S, and the ramp change R over 10 min. Geomagnetic latitude maps of the cumulative exceedances of these three quantities are constructed, giving the threshold (nT/min) for which activity within a 24 h period can be expected to occur once per year, decade, and century. Specifically, at geomagnetic 55°, we estimate once-per-century ΔBh, S, and R exceedances and a site-to-site, proportional, 1 standard deviation range [1 σ, lower and upper] to be, respectively, 1000, [690, 1450]; 500, [350, 720]; and 200, [140, 280] nT/min. At 40°, we estimate once-per-century ΔBh, S, and R exceedances and 1 σ values to be 200, [140, 290]; 100, [70, 140]; and 40, [30, 60] nT/min.

  14. High passage MIN6 cells have impaired insulin secretion with impaired glucose and lipid oxidation.

    Directory of Open Access Journals (Sweden)

    Kim Cheng

    Full Text Available Type 2 diabetes is a metabolic disorder characterized by the inability of beta-cells to secrete enough insulin to maintain glucose homeostasis. MIN6 cells secrete insulin in response to glucose and other secretagogues, but high passage (HP MIN6 cells lose their ability to secrete insulin in response to glucose. We hypothesized that metabolism of glucose and lipids were defective in HP MIN6 cells causing impaired glucose stimulated insulin secretion (GSIS. HP MIN6 cells had no first phase and impaired second phase GSIS indicative of global functional impairment. This was coupled with a markedly reduced ATP content at basal and glucose stimulated states. Glucose uptake and oxidation were higher at basal glucose but ATP content failed to increase with glucose. HP MIN6 cells had decreased basal lipid oxidation. This was accompanied by reduced expressions of Glut1, Gck, Pfk, Srebp1c, Ucp2, Sirt3, Nampt. MIN6 cells represent an important model of beta cells which, as passage numbers increased lost first phase but retained partial second phase GSIS, similar to patients early in type 2 diabetes onset. We believe a number of gene expression changes occurred to produce this defect, with emphasis on Sirt3 and Nampt, two genes that have been implicated in maintenance of glucose homeostasis.

  15. Disruption of estrogen receptor signaling enhances intestinal neoplasia in ApcMin/+ mice

    Science.gov (United States)

    Cleveland, Alicia G.; Oikarinen, Seija I.; Bynoté, Kimberly K.; Marttinen, Maija; Rafter, Joseph J.; Gustafsson, Jan-Åke; Roy, Shyamal K.; Pitot, Henry C.; Korach, Kenneth S.; Lubahn, Dennis B.; Mutanen, Marja; Gould, Karen A.

    2009-01-01

    Estrogen receptors (ERs) [ERα (Esr1) and ERβ (Esr2)] are expressed in the human colon, but during the multistep process of colorectal carcinogenesis, expression of both ERα and ERβ is lost, suggesting that loss of ER function might promote colorectal carcinogenesis. Through crosses between an ERα knockout and ApcMin mouse strains, we demonstrate that ERα deficiency is associated with a significant increase in intestinal tumor multiplicity, size and burden in ApcMin/+ mice. Within the normal intestinal epithelium of ApcMin/+ mice, ERα deficiency is associated with an accumulation of nuclear β-catenin, an indicator of activation of the Wnt–β-catenin-signaling pathway, which is known to play a critical role in intestinal cancers. Consistent with the hypothesis that ERα deficiency is associated with activation of Wnt–β-catenin signaling, ERα deficiency in the intestinal epithelium of ApcMin/+ mice also correlated with increased expression of Wnt–β-catenin target genes. Through crosses between an ERβ knockout and ApcMin mouse strains, we observed some evidence that ERβ deficiency is associated with an increased incidence of colon tumors in ApcMin/+ mice. This effect of ERβ deficiency does not involve modulation of Wnt–β-catenin signaling. Our studies suggest that ERα and ERβ signaling modulate colorectal carcinogenesis, and ERα does so, at least in part, by regulating the activity of the Wnt–β-catenin pathway. PMID:19520794

  16. Decay of mass-separated 189mHg (8.7 min) and 189gHg (7.7 min) to 189Au

    International Nuclear Information System (INIS)

    Wood, J.L.; Zganjar, E.F.; Semmes, P.B.

    1996-01-01

    The decays of 189 Hg (8.7 min; J π =13/2 + ) and 189 Hg (7.7 min; J π =3/2 - ) have been studied with mass-separated sources from the UNISOR facility. Multiscaled spectra of γ-rays, X-rays, and conversion electrons, as well as γγt, γXt, eγt, and eXt coincidences were obtained. Decay schemes have been constructed incorporating >95% of the decay intensities assigned to the high-spin and low-spin decays. The γ-ray gated conversion-electron spectra permitted the determination of 119 conversion-electron subshell ratios. Portions of the level scheme bear a remarkable resemblance to the heavier and lighter odd-mass Au isotopes. An extensive band of states is observed built upon the h 9/2 intruder state at 325 keV. This band is markedly different from the corresponding bands in 187 Au and 185 Au, indicating a major change in the cores, i.e. between 188 Pt and 186,184 Pt. Evidence for oblate-hole-prolate-particle symmetry in 189 Au is discussed. Completeness of complex decay schemes far from stability is addressed. (orig.)

  17. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Pharmacology”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Pharmacology”ABS 1. BABY SKIN CARE PRODUCTS • P. Doro, R. Abraham, D. Agoston, J. Balog, R.Z. CsomaABS 2. MATHEMATICAL MODELING TO PREDICT IN-HOSPITAL NATURAL WEIGHT CHANGES IN TERM NEONATES • S. Kasser, M. Wilbaux, C. De Angelis, H. Rickenbacher, N. Klarer, J.N. Van Den Anker, M. Pfister, S. WellmannABS 3. IMPROVING PARENTERAL NUTRITION IN THE NEONATE – A PRACTICAL GUIDELINE • H. Reigstad, D. Moster, I. Grønlie, A. BlystadABS 4. INVOLUTION OF RETINOPATHY OF PREMATURITY AND NEURODEVELOPMENTAL OUTCOME AFTER BEVACIZUMAB TREATMENT • Y.-S. Chang, P.-N. Tsao, C.-Y. Chen, H.-C. Chou, W.-S. Hsieh, P.-T. YehABS 5. RELATIONSHIP BETWEEN ADVERSE DRUG REACTIONS AND OFF-LABEL/UNLICENSED DRUG USE IN HOSPITALISED CHILDREN. EREMI STUDY • K.A. Nguyen, Y. Mimouni, A. Lajoinie, N. Paret, S. Malik, L. El-Amrani, L. Milliat-Guittard, C. Carcel, A. Portefaix, A.M. Schott, T. Vial, B. KassaiABS 6. A SYSTEMATIC REVIEW OF OFF-LABEL AND UNLICENSED DRUGS USE AND ADVERSE DRUG REACTIONS IN HOSPITALIZED CHILDREN • N. David, K.A. Nguyen, Y. Mimouni, A. Lajoinie, S. Malik, B. KassaiABS 7. EFFICACY AND SAFETY OF PROPOFOL SEDATION

  18. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Neonatal Hematology and Bilirubin"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Neonatal Hematology and Bilirubin"ABS 1. PROLONGED JAUNDICE SCREENING: FULL BLOOD COUNT (FBC OR NO FBC! • N. Storring, R. Doherty, V. PonnusamyABS 2. EFFECT OF PROBIOTIC SUPPLEMENTATION ON BREAST MILK JAUNDICE • N. Koksal, O. Bagcı, H. Ozkan, I. Varal, P. DoganABS 3. LABORATORY FINDINGS, DIAGNOSIS AND TREATMENT OF THE NEWBORN ADMITTED DUE TO HEMATEMESIS OR BLOODY STOOL IN 11 YEARS • I. Hokuto, Y. Ito, T. Mori, S. KomachiABS 4. AN UNUSUAL CAUSE OF CYANOSIS: SEVERE METHEMOGLOBINEMIA IN A PRETERM INFANT WITH SEPSIS • F. Bakar, M. BerberABS 5. THE INFLUENCE OF INTRAUTERINE TRANSFUSION ON THE OUTCOMES OF NEWBORNS WITH SEVERE HEMOLYTIC DISEASE • E. Balashova, O. Bystrykh, T. Fedorova, O. Ionov, A. Kirtbaya, D. Sharafutdinova, V. Zubkov, D. Degtyarev, O. Horoshkeeva, N. Fedorova, N. Tetruashvili, K. Kostukov, N. KaretnikovaABS 6. PATCHED SKIN BILIRUBIN ASSAY TO MONITOR EXTREMELY PRETERM NEONATES UNDERGOING PHOTOTHERAPY • D. De Luca, V. Dell’OrtoABS 7. A PRETERM MODEL OF HYPERBILIRUBINEMIA-INDUCED CEREBELLAR DYSFUNCTION • C.F. Bearer, M. He, J.F. Watchko, J.M. Simard, N. Tang

  19. Therapeutic utility of aspirin in the ApcMin/+ murine model of colon carcinogenesis

    International Nuclear Information System (INIS)

    Reuter, Brian K; Zhang, Xiao-Jing; Miller, Mark JS

    2002-01-01

    In recent years it has become evident that nonsteroidal anti-inflammatory drugs, in particular aspirin represent a potential class of cancer chemotherapeutic agents. Despite the wealth of knowledge gained from epidemiological, clinical and animal studies, the effectiveness of aspirin to treat established gastrointestinal cancer has not been determined. The present study examines the ability of aspirin to treat established polyposis in Min/+ mice. Min/+ mice with established polyposis were treated orally once daily from 12–16 weeks of age with either drug vehicle or aspirin (25 mg/kg). Upon completion of treatment, the number, location and size of intestinal tumours was determined. Additional variables examined were the number of apoptotic cells within tumours and COX activity. Administration of aspirin for 4 weeks to Min/+ mice produce no effect on tumour number compared to vehicle-treated Min/+ mice (65 ± 8 vs. 63 ± 9, respectively). In addition, aspirin had no effect on tumour size or location. However, aspirin treatment produced a greater than 2-fold (p < 0.05) increase in the number of apoptotic positive cells within tumours and significantly decreased hepatic PGE 2 content. Aspirin was found to have no effect on tumour number and size when administered to Min/+ mice with established polyposis. The findings in the present study call in to question the utility of aspirin as a stand-alone treatment for established GI cancer. However, aspirin's ability to significantly promote apoptosis may render it suitable for use in combinatorial chemotherapy

  20. The 1-min sit-to-stand test in cystic fibrosis - Insights into cardiorespiratory responses.

    Science.gov (United States)

    Radtke, Thomas; Hebestreit, Helge; Puhan, Milo A; Kriemler, Susi

    2017-11-01

    We aimed to characterize the cardiopulmonary response during a 1-min sit-to-stand (STS) test and compare peak exercise cardiorespiratory variables to a maximal cardiopulmonary exercise test (CPET) in cystic fibrosis (CF). We further aimed to assess the validity of the STS power index (Power STS ) as a measure of exercise capacity. Fifteen adult CF patients performed spirometry, CPET and the 1-min STS test with respiratory gas analysis. Peak-exercise cardiorespiratory variables during the 1-min STS test correlated strongly (r=0.69-0.98) with those measured during the CPET. Oxygen uptake, carbon dioxide production, heart rate, ventilation, and tidal volume at peak exercise were 24%, 26%, 9%, 10% and 21% lower in the 1-min STS test, while respiratory frequencies were 14% higher. Power STS showed strong to very strong correlations with CPET-derived absolute peak oxygen uptake and maximal workload. The 1-min STS test elicits a substantial but lower cardiorespiratory response compared to a maximal cycle ergometry CPET. While Power STS and STS repetitions are both valid outcome measures of functional capacity, STS repetitions are clinically more practical. Copyright © 2017 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

  1. [Professor YANG Zhao-min's contribution to the education of modern acupuncture and moxibustion].

    Science.gov (United States)

    Dong, Qin; Mu, Yan-Yun; Xia, You-Bing; Zhang, Jian-Bin

    2012-05-01

    It was completely collected and summarized the teaching history and the relevant historical materials of Professor YANG Zhao-min via consulting the literatures, investigation, interview, etc. in this paper. The summaries indicated that from the beginning of running a school, Professor YANG Zhao-min adhered to the CHENG's moral, worked hard and successfully explored and practiced the training pattern of teaching tour for the personnel training of acupuncture and moxibustion. He established the specialty of acupuncture and moxibustion, formatted courses and inherited the feature of practice teaching. He was in charge of the compilation of textbook and engaged in scientific innovation. He inherited the past and forged ahead into the future and had made the decision to cultivate the personnel of acupuncture and moxibustion. Professor YANG Zhao-min had practiced and developed the modern educational thought from the CHENG Dan-an and had made the important contribution to the training of acupuncture and moxibustion professionals.

  2. Determinants of poor 6-min walking distance in patients with COPD: the ECLIPSE cohort

    DEFF Research Database (Denmark)

    Spruit, Martijn A; Watkins, Michael L; Edwards, Lisa D

    2010-01-01

    >/=2) are significant clinical determinants of poor 6MWD performance (poor 6MWD are complex and depend on both physical (both pulmonary and non-pulmonary factors) and psychological factors as evaluated from a large multinational cohort of well......BACKGROUND: The 6-min walking test (6MWT) is widely used to assess exercise tolerance in patients with chronic obstructive pulmonary disease (COPD). Given the prognostic significance of the 6MWT, it is important to identify why some COPD patients perform poorly in terms of this outcome. We aimed...... to identify clinical determinants of a poor 6-min walking distance (

  3. AtMIN7 mediated disease resistance to Pseudomonas syringae in Arabidopsis

    Science.gov (United States)

    He, Sheng Yang [Okemos, MI; Nomura, Kinya [East Lansing, MI

    2011-07-26

    The present invention relates to compositions and methods for enhancing plant defenses against pathogens. More particularly, the invention relates to enhancing plant immunity against bacterial pathogens, wherein AtMIN7 mediated protection is enhanced and/or there is a decrease in activity of an AtMIN7 associated virulence protein such as a Pseudomonas syringae pv. tomato DC3000 HopM1. Reagents of the present invention provide a means of studying cellular trafficking while formulations of the present inventions provide increased pathogen resistance in plants.

  4. Quantum key distribution with finite resources: Smooth Min entropy vs. Smooth Renyi entropy

    Energy Technology Data Exchange (ETDEWEB)

    Mertz, Markus; Abruzzo, Silvestre; Bratzik, Sylvia; Kampermann, Hermann; Bruss, Dagmar [Institut fuer Theoretische Physik III, Duesseldorf (Germany)

    2010-07-01

    We consider different entropy measures that play an important role in the analysis of the security of QKD with finite resources. The smooth min entropy leads to an optimal bound for the length of a secure key. Another bound on the secure key length was derived by using Renyi entropies. Unfortunately, it is very hard or even impossible to calculate these entropies for realistic QKD scenarios. To estimate the security rate it becomes important to find computable bounds on these entropies. Here, we compare a lower bound for the smooth min entropy with a bound using Renyi entropies. We compare these entropies for the six-state protocol with symmetric attacks.

  5. Optimized Min-Sum Decoding Algorithm for Low Density Parity Check Codes

    OpenAIRE

    Mohammad Rakibul Islam; Dewan Siam Shafiullah; Muhammad Mostafa Amir Faisal; Imran Rahman

    2011-01-01

    Low Density Parity Check (LDPC) code approaches Shannon–limit performance for binary field and long code lengths. However, performance of binary LDPC code is degraded when the code word length is small. An optimized min-sum algorithm for LDPC code is proposed in this paper. In this algorithm unlike other decoding methods, an optimization factor has been introduced in both check node and bit node of the Min-sum algorithm. The optimization factor is obtained before decoding program, and the sam...

  6. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Cardiac Physiology and Pathology"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Cardiac Physiology and Pathology"ABS 1. EVALUATION OF THE RELATIONSHIP BETWEEN PATENT DUCTUS ARTERIOSUS AND THE PLATELET MASS INDEX IN PRETERM INFANTS • M. Kara, İ. Caner, K.Ş. Tekgündüz, İ. Polat, H. KeskinABS 2. DIAGNOSIS OF DIGEORGE SYNDROME: THE CONTRIBUTION OF MOLECULAR GENETICS • Y. Halleb, H. Hadj-Abdallah, S. Nouri, A. Touati, M. Bellallah, J. Mathlouthi, N. Mahdhaoui, H. Sboui, A. Saad, D. H’midaABS 3. ASSOCIATION BETWEEN SIZE OF PATENT DUCTUS ARTERIOSUS AND CO-MORBIDITIES • S. Bellis, Y. SinghABS 4. EFFICACY OF MEDICAL TREATMENT IN CLOSING PATENT DUCTUS ARTERIOSUS IN ELBW INFANTS • S. Bellis, Y. SinghABS 5. ACETAMINOPHEN FOR CLOSING PDA. SHOULD IT BE A FIRST LINE THERAPEUTIC OPTION? • I. Tofé, M.D. Ruiz, M.P. Jaraba, M.V. Rodriguez, R.L. Rueda, M.D. Ordoñez, M.J. ParragaABS 6. PATENT DUCTUS ARTERIOSUS WITH HEMODYNAMIC REPERCUSSION IN VERY LOW WEIGHT PRETERM INFANTS TREATED WITH ORAL IBUPROFEN PRESENTS A HIGH RATE OF BRONCHOPULMONARY DYSPLASIA • M.M. Lourenço, E. Sacramento, F. Carmona, C. Calixto, F. Martin-Celini, G.H. Seribelli, W.A. Gonçalves-FerriABS 7

  7. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Epidemiology”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Epidemiology”ABS 1. A PERFORMANCE INDICATOR FOR THE PROLONGATION OF GESTATIONAL AGE • N. LackABS 2. LATE PRETERM NEONATES AND CAUSES OF ADMISSION TO THE NICU • S. Arayici, G. Kadioglu Simsek, B. Say, E. Alyamac Dizdar, N. Uras, F.E. Canpolat, S.S. OguzABS 3. INCIDENCE AND OUTCOMES OF METABOLIC DISORDERS IN VERY PRETERM INFANTS • O. Dobush, D. Dobryanskyy, Z. Salabay, O. Detsyk, O. Novikova, Y. KuzminovABS 4. MATERNAL FACTORS INFLUENCE INFANT’S VITAMIN D STATUS • H. Hauta-alus, E. Holmlund-Suila, M. Enlund-Cerullo, J. Rosendahl, S. Valkama, O. Helve, H-M. Surcel, O. Mäkitie, S. Andersson, H. ViljakainenABS 5. THE HIGH PREVALENCE OF VITAMIN D DEFICIENCY IN A LARGE NUMBER OF PREGNANT WOMEN AND RELATED FACTORS IN ANKARA, TURKEY • G. Kadioglu Simsek, F. E. Canpolat, S. Arayici, G. Kanmaz Kutman, H.I. Yakut, Ö. Moraloğlu, B. ÖzkanABS 6. SNAPPE-II: A VALUABLE PREDICTOR OF ADVERSE OUTCOMES IN PREMATURITY • P. Costa-Reis, R. Monteiro, M. Abrantes, P. Costa, A. Graça, C. MonizABS 7. THE ASSOCIATION BETWEEN MATERNAL AND FETAL 25OHD AND INFANT SIZE AND ADIPOSITY AT BIRTH, 6 MONTHS AND 2 YEARS OF AGE • M

  8. Statistical Properties of Gamma-Ray Burst Host Galaxies Jie-Min ...

    Indian Academy of Sciences (India)

    Statistical Properties of Gamma-Ray Burst Host Galaxies. Jie-Min Chen1, Jin Zhang2,3, ... of GRB host galaxies and explore possible correlations between these properties. We also investigate possible cosmic ... hydrogen column density for the GRB host galaxies in our sample. 6.295. The stellar masses are mainly in the ...

  9. Demonstrating the Open Data Repository's Data Publisher: The CheMin Database

    Science.gov (United States)

    Stone, N.; Lafuente, B.; Bristow, T.; Pires, A.; Keller, R. M.; Downs, R. T.; Blake, D.; Dateo, C. E.; Fonda, M.

    2018-04-01

    The Open Data Repository's Data Publisher aims to provide an easy-to-use software tool that will allow researchers to create and publish database templates and related data. The CheMin Database developed using this framework is shown as an example.

  10. Minásbate Equivalents of Mathematical Concepts: Their Socio-Cultural Undertones

    Science.gov (United States)

    Balbuena, Sherwin E.; Cantoria, Uranus E.; Cantoria, Amancio L., Jr.; Ferriol, Eny B.

    2015-01-01

    This paper presents the collection and analysis of Minásbate equivalents of some concepts used in the study of arithmetic, counting, and geometry as provided by the elderly residents of the province of Masbate. The glossary of mathematical terms derived from interviews would serve as an authoritative reference for mother tongue teachers in the…

  11. MODIS/Terra Calibrated Radiances 5-Min L1B Swath 1km V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The MODIS/Terra Calibrated Radiances 5-Min L1B Swath 1km (MOD021KM) contains calibrated and geolocated at-aperture radiances for 36 discrete bands located in the 0.4...

  12. Simultaneous detection of the 160-min pulsations of the Sun with two radiotelescopes

    International Nuclear Information System (INIS)

    Nesterov, N.S.; Urno, S.; Kotov, V.A.

    1983-01-01

    The differential (center-to-limb) radio briqhtness of the quet Sun was measured on June 22, 1981 simultaneously in Crimea at 13.5-mm wavelength and in Finland at 8-mm wavelength. Both independent sets of observations have shown the presence of synchronous variation of the solar radioemission with the 160-min period

  13. Separation of sup(115m)In from mother 115Cd

    International Nuclear Information System (INIS)

    Kersulis, V.J.

    1979-01-01

    The methods of the accelerated isolation of the metallic sup(115m)In from the mother solution of 115 Cd were worked out. The sample was dissolved in the concentrated HCl with the presence of H 2 O 2 . After the injection of 5 mg (recalculated for the metallic In) of the carrier, the solution was evaporated dry, the remainder was dissolved in 2n HCl. The obtained solution was lead through an ion-exchange column (9 mm in diameter and with the 250 mm height of the layer with the anionite Dowex 2x8 (50-100 mesh). The sup(115m)In was eluated by 0.15n HCl, and 115 Cd - by 1.5n HCl. Radiochemical purity of the sup(115m)In was not less than 99.99%. The isolation of the sup(115m)In from the eluent (alkalined up to ph=2.3) was carried out electrochemically during approximately 1 hour on the platinum cathode at high (400 mA/cm 2 ) cathode density of current

  14. A Modified MinMax k-Means Algorithm Based on PSO.

    Science.gov (United States)

    Wang, Xiaoyan; Bai, Yanping

    The MinMax k -means algorithm is widely used to tackle the effect of bad initialization by minimizing the maximum intraclustering errors. Two parameters, including the exponent parameter and memory parameter, are involved in the executive process. Since different parameters have different clustering errors, it is crucial to choose appropriate parameters. In the original algorithm, a practical framework is given. Such framework extends the MinMax k -means to automatically adapt the exponent parameter to the data set. It has been believed that if the maximum exponent parameter has been set, then the programme can reach the lowest intraclustering errors. However, our experiments show that this is not always correct. In this paper, we modified the MinMax k -means algorithm by PSO to determine the proper values of parameters which can subject the algorithm to attain the lowest clustering errors. The proposed clustering method is tested on some favorite data sets in several different initial situations and is compared to the k -means algorithm and the original MinMax k -means algorithm. The experimental results indicate that our proposed algorithm can reach the lowest clustering errors automatically.

  15. Return period curves for extreme 5-min rainfall amounts at the Barcelona urban network

    Science.gov (United States)

    Lana, X.; Casas-Castillo, M. C.; Serra, C.; Rodríguez-Solà, R.; Redaño, A.; Burgueño, A.; Martínez, M. D.

    2018-03-01

    Heavy rainfall episodes are relatively common in the conurbation of Barcelona and neighbouring cities (NE Spain), usually due to storms generated by convective phenomena in summer and eastern and south-eastern advections in autumn. Prevention of local flood episodes and right design of urban drainage have to take into account the rainfall intensity spread instead of a simple evaluation of daily rainfall amounts. The database comes from 5-min rain amounts recorded by tipping buckets in the Barcelona urban network along the years 1994-2009. From these data, extreme 5-min rain amounts are selected applying the peaks-over-threshold method for thresholds derived from both 95% percentile and the mean excess plot. The return period curves are derived from their statistical distribution for every gauge, describing with detail expected extreme 5-min rain amounts across the urban network. These curves are compared with those derived from annual extreme time series. In this way, areas in Barcelona submitted to different levels of flood risk from the point of view of rainfall intensity are detected. Additionally, global time trends on extreme 5-min rain amounts are quantified for the whole network and found as not statistically significant.

  16. Numerical Analysis of Strongly Nonlinear Oscillation Systems using He's Max-Min Method

    DEFF Research Database (Denmark)

    Babazadeh, H; Domairry, G; Barari, Amin

    2011-01-01

    Nonlinear functions are crucial points and terms in engineering problems. Actual and physical problems can be solved by solving and processing such functions. Thus, most scientists and engineers focus on solving these equations. This paper presents a novel method called the max-min method...

  17. Min st-cut oracle for planar graphs with near-linear preprocessing time

    DEFF Research Database (Denmark)

    Borradaile, Glencora; Sankowski, Piotr; Wulff-Nilsen, Christian

    2010-01-01

    For an undirected n-vertex planar graph G with non-negative edge-weights, we consider the following type of query: given two vertices s and t in G, what is the weight of a min st-cut in G? We show how to answer such queries in constant time with O(n log5 n) preprocessing time and O(n log n) space....... We use a Gomory-Hu tree to represent all the pairwise min st-cuts implicitly. Previously, no subquadratic time algorithm was known for this problem. Our oracle can be extended to report the min st-cuts in time proportional to their size. Since all-pairs min st-cut and the minimum cycle basis are dual...... problems in planar graphs, we also obtain an implicit representation of a minimum cycle basis in O(n log5 n) time and O(n log n) space and an explicit representation with additional O(C) time and space where C is the size of the basis. To obtain our results, we require that shortest paths be unique...

  18. Effect of a 5-min cold-water immersion recovery on exercise performance in the heat.

    Science.gov (United States)

    Peiffer, J J; Abbiss, C R; Watson, G; Nosaka, K; Laursen, P B

    2010-05-01

    This study examined the effect of a 5-min cold-water immersion (14 degrees C) recovery intervention on repeated cycling performance in the heat. 10 male cyclists performed two bouts of a 25-min constant-paced (254 (22) W) cycling session followed by a 4-km time trial in hot conditions (35 degrees C, 40% relative humidity). The two bouts were separated by either 15 min of seated recovery in the heat (control) or the same condition with 5-min cold-water immersion (5th-10th minute), using a counterbalanced cross-over design (CP(1)TT(1) --> CWI or CON --> CP(2)TT(2)). Rectal temperature was measured immediately before and after both the constant-paced sessions and 4-km timed trials. Cycling economy and Vo(2) were measured during the constant-paced sessions, and the average power output and completion times were recorded for each time trial. Compared with control, rectal temperature was significantly lower (0.5 (0.4) degrees C) in cold-water immersion before CP(2) until the end of the second 4-km timed trial. However, the increase in rectal temperature (0.5 (0.2) degrees C) during CP(2) was not significantly different between conditions. During the second 4-km timed trial, power output was significantly greater in cold-water immersion (327.9 (55.7) W) compared with control (288.0 (58.8) W), leading to a faster completion time in cold-water immersion (6.1 (0.3) min) compared with control (6.4 (0.5) min). Economy and Vo(2) were not influenced by the cold-water immersion recovery intervention. 5-min cold-water immersion recovery significantly lowered rectal temperature and maintained endurance performance during subsequent high-intensity exercise. These data indicate that repeated exercise performance in heat may be improved when a short period of cold-water immersion is applied during the recovery period.

  19. Nuclear decay scheme studies of 30-h 131Te/sup m/, 25-min 131Te/sup g/, and 55.5-min 105Cd

    International Nuclear Information System (INIS)

    Jackson, S.V.

    1975-01-01

    High-resolution Ge(Li) detectors have been used to observe γ-ray singles and coincidence spectra of 30-h 11 / 2 - , /sup 131m/Te, 25-min 3 / 2 + , and 55.5-min 5 / 2 + 105 Cd. Sources of /sup 131m/Te and /sup 131g/Te were produced by neutron irradiation of enriched 130 Te metal, and, in the case of /sup 131m/Te, were chemically purified to remove the 131 I daughter. A total of 190 and 80 γ-rays are attributed to the decays of /sup 131m/Te and /sup 131g/Te, respectively; and 174 and 77 of these transitions have been placed in a 131 I level scheme involving 52 excited states. Absolute β group intensities were determined for the transitions to 131 I levels. Spin and parity assignments were made for all observed levels. The β feeding from the 11 / 2 - /sup 131m/Te to the 7 / 2 + 131 I ground state was determined to be (5.2 +- 3.0) percent (log ft = 10.5). The isomeric transition of 11 / 2 - /sup 131m/Te to 3 / 2 + /sup 131g/Te was determined to be (22.2 +- 1.6) percent. The 6-nsec isomer in 131 I at 1797 keV has been assigned as 15 / 2 - and interpreted as a πν 1 ν 2 three quasi-particle state. Sources of 105 Cd were produced via the 106 Cd(n,2n) reaction on enriched 106 CdO using 14 MeV neutrons. A total of 274 γ-rays are attributed to the decay of 105 Cd, and 248 of these have been placed in a 105 Ag level scheme involving 50 excited states. Absolute values for the β + /EC transition intensities to 105 Ag levels were determined. The β + /EC feeding from the 5 / 2 + 105 Cd to the 7 / 2 + 25.5-keV isomeric state in 105 Ag was determined to be (51.4 +- 4.0) percent (log ft = 5.4). The experimentally determined level structures of 131 I and 105 Cd are interpreted in terms of the shell model and core excitation considerations with emphasis placed on the core coupling model and the three-particle models. (U.S.)

  20. Curcumin suppresses intestinal polyps in APC Min mice fed a high fat diet

    Directory of Open Access Journals (Sweden)

    Christina Pettan-Brewer

    2011-06-01

    Full Text Available Colorectal cancer (CRC is a leading cause of cancer deaths in the United States. Various risk factors have been associated with CRC including increasing age and diet. Epidemiological and experimental studies have implicated a diet high in fat as an important risk factor for colon cancer. High fat diets can promote obesity resulting in insulin resistance and inflammation and the development of oxidative stress, increased cell proliferation, and suppression of apoptosis. Because of the high consumption of dietary fats, especially saturated fats, by Western countries, it is of interest to see if non-nutrient food factors might be effective in preventing or delaying CRC in the presence of high saturated fat intake. Curcumin (Curcuma longa, the main yellow pigment in turmeric, was selected to test because of its reported anti-tumor activity. APC Min mice, which develop intestinal polyps and have many molecular features of CRC, were fed a diet containing 35% pork fat, 33% sucrose, and a protein and vitamin mineral mixture (HFD with or without 0.5% curcumin. These cohorts were compared to APC Min mice receiving standard rodent chow (RC with 8% fat. APC Min mice fed the HFD for 3 months had a 23% increase in total number of polyps compared to APC Min mice on RC. Curcumin was able to significantly reverse the accelerated polyp development associated with the HFD suggesting it may be effective clinically in helping prevent colon cancer even when ingesting high amounts of fatty foods. The anti-tumor effect of curcumin was shown to be associated with enhanced apoptosis and increased efficiency of DNA repair. Since curcumin prevented the gain in body weight seen in APC Min mice ingesting the HFD, modulation of energy metabolism may also be a factor.

  1. Intestinal tumor suppression in ApcMin/+ mice by prostaglandin D2 receptor PTGDR

    International Nuclear Information System (INIS)

    Tippin, Brigette L; Kwong, Alan M; Inadomi, Michael J; Lee, Oliver J; Park, Jae Man; Materi, Alicia M; Buslon, Virgilio S; Lin, Amy M; Kudo, Lili C; Karsten, Stanislav L; French, Samuel W; Narumiya, Shuh; Urade, Yoshihiro; Salido, Eduardo; Lin, Henry J

    2014-01-01

    Our earlier work showed that knockout of hematopoietic prostaglandin D synthase (HPGDS, an enzyme that produces prostaglandin D 2 ) caused more adenomas in Apc Min/+ mice. Conversely, highly expressed transgenic HPGDS allowed fewer tumors. Prostaglandin D 2 (PGD 2 ) binds to the prostaglandin D 2 receptor known as PTGDR (or DP1). PGD 2 metabolites bind to peroxisome proliferator-activated receptor γ (PPARG). We hypothesized that Ptgdr or Pparg knockouts may raise numbers of tumors, if these receptors take part in tumor suppression by PGD 2 . To assess, we produced Apc Min/+ mice with and without Ptgdr knockouts (147 mice). In separate experiments, we produced Apc Min/+ mice expressing transgenic lipocalin-type prostaglandin D synthase (PTGDS), with and without heterozygous Pparg knockouts (104 mice). Homozygous Ptgdr knockouts raised total numbers of tumors by 30–40% at 6 and 14 weeks. Colon tumors were not affected. Heterozygous Pparg knockouts alone did not affect tumor numbers in Apc Min/+ mice. As mentioned above, our Pparg knockout assessment also included mice with highly expressed PTGDS transgenes. Apc Min/+ mice with transgenic PTGDS had fewer large adenomas (63% of control) and lower levels of v-myc avian myelocytomatosis viral oncogene homolog (MYC) mRNA in the colon. Heterozygous Pparg knockouts appeared to blunt the tumor-suppressing effect of transgenic PTGDS. However, tumor suppression by PGD 2 was more clearly mediated by receptor PTGDR in our experiments. The suppression mechanism did not appear to involve changes in microvessel density or slower proliferation of tumor cells. The data support a role for PGD 2 signals acting through PTGDR in suppression of intestinal tumors

  2. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Circulation, Macro- and Microcirculation"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Circulation, Macro- and Microcirculation"ABS 1. MOLECULAR AND GENETIC MARKERS FOR PREDICTION OF RESISTANCE TO INOTROPIC THERAPY IN NEWBORNS WITH ARTERIAL HYPOTENSION • D. Kryuchko, A. Donnikov, E. Baibarina, I. Nikitina, O. Ionov, D. DegtyarevABS 2. GUT AND CEREBRAL OXYGENATION FROM BIRTH TO SIX WEEKS OF LIFE IN PRETERM INFANTS: WHAT IS NORMAL? • C. Howarth, T. Leung, J. Banerjee, J. Morris, N. AladangadyABS 3. CHANGES OF NT-PROBNP CONCENTRATION WITHIN THE FIRST WEEK OF LIFE IN PRETERM NEWBORNS WITH BIRTH WEIGHT ≤ 1,200 G • T. Talar, E. Gulczyńska, B. Cyranowicz, J. MollABS 4. RESISTANCE INDEX (RI OF ARTERIA CEREBRI ANTERIOR AND CEREBRAL OXYGENATION IN PRETERM INFANTS • N. Baik-Schneditz, B. Urlesberger, B. Schwaberger, L. Mileder, N. Höller, G. PichlerABS 5. THE INFLUENCE OF MATERNAL MEDICATION ON CLOSURE OF THE DUCTUS ARTERIOSUS IN THE PREMATURE NEWBORN • W.P. de Boode, J. van Drongelen, M.J.A. RaaymakersABS 6. INFLUENCE OF GLOBAL HYPOXIA AND REMOTE ISCHEMIC POSTCONDITIONING ON NATRIURETIC PEPTIDE EXPRESSION IN NEWBORN PIGLET HEART CHAMBERS • H. Kierkegaard, K.J. Kyng, B

  3. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Epidemiology and Networks"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Epidemiology and Networks"ABS 1. AN EVALUATION OF DOCTORS AND MEDICAL STUDENT’S KNOWLEDGE OF PAEDIATRIC VACCINATIONS IN PAKISTAN • N. NadeemABS 2. AN EVALUATION OF DOCTORS AND MEDICAL STUDENT’S ATTITUDES AND BELIEFS OF PAEDIATRIC VACCINATIONS IN PAKISTAN • N. NadeemABS 3. APPLYING DATA MINING TECHNIQUES TO PREDICT BRONCHOPULMONARY DYSPLASIA IN VERY-LOW-BIRTH-WEIGHT (VLBW INFANTS. A POPULATION-BASED STUDY • Y.J. Lin, C.H. Lin, Y.C. Lin, Y.S. Chang, C.C. Huang, K.I. TsouABS 4. IN UTERO EXPOSURE TO PERFLUOROALKYL AND POLYFLUOROALKYL SUBSTANCES AND ATTENTION AND EXECUTIVE FUNCTION IN THE OFFSPRING • C.C. Bach, Z. Liew, N.B. Matthiesen, T.B. Henriksen, B.H. Bech, E.A. Nohr, E.C. Bonefeld-Jørgensen, J. OlsenABS 5. MORTALITY, MORBIDITY AND SHORT-TERM RETINOPATHY OF PREMATURITY OUTCOMES IN EXTREME PRETERM NEONATES: A 5 YEAR STUDY • H. Jarvis, M. Sdobnikovs, J. William, F. Dean, P. SatodiaABS 6. ASSOCIATION BETWEEN MATERNAL BODY MASS INDEX IN EARLY PREGNANCY AND INCIDENCE OF CEREBRAL PALSY • S. Johansson, E. Villamor, K. Tedroff, M. Peterson, M. Neovius, G. Petersson, S

  4. Using the Min/Max Method for Replenishment of Picking Locations

    Directory of Open Access Journals (Sweden)

    Apsalons Raitis

    2017-03-01

    Full Text Available The irregularity of removing quantities from a definite picking location in a warehouse very often results in the stock out in the particular picking address. In practice, the Red Card principle is used to determine a critical level for each picking location when it is necessary to start the replenishment of stock in the picking address. The question is how to calculate an adequate critical level. The guidelines in this paper explain in detail the solution of the problem using the Min/Max stock control method and mathematical algorithms adjusted by authors. In order to check the validity of these mathematical algorithms of the Min/Max method, the simulation modelling has been also done and presented.

  5. [Contribution of Professor SHI Xue-min's academic thoughts to treatment of stroke].

    Science.gov (United States)

    Liu, Jian; Fan, Xiao-Nong; Wang, Shu

    2014-01-01

    Based on the thought of Zhishen (a kind of mind regulation), Professor SHI Xue-min, academician of the China Academy of Engineering, found the Xingnao Kaiqiao (to refresh the mind and to cause resuscitation) acupuncture method, which still plays an important role in the acupuncture treatment of wind stroke nowadays. Meanwhile, great importance is attached to the comprehensive treatment of wind stroke. Danqi Piantan capsule (see text) is developed and "wind stroke unit" is set up. In recent years, Professor SHI shifts the center of research to the treatment of hypertension, the risk factor of wind stroke. Taking Renying (ST 9) as the major acupoint, acupuncture with standard measurement and manipulations is established. And good clinical effect has been obtained as well. Therefore, this article focuses on the introduction of Professor SHI Xue-min's contribution to wind stroke treatment.

  6. Reducing Conservatism in Aircraft Engine Response Using Conditionally Active Min-Max Limit Regulators

    Science.gov (United States)

    May, Ryan D.; Garg, Sanjay

    2012-01-01

    Current aircraft engine control logic uses a Min-Max control selection structure to prevent the engine from exceeding any safety or operational limits during transients due to throttle commands. This structure is inherently conservative and produces transient responses that are slower than necessary. In order to utilize the existing safety margins more effectively, a modification to this architecture is proposed, referred to as a Conditionally Active (CA) limit regulator. This concept uses the existing Min-Max architecture with the modification that limit regulators are active only when the operating point is close to a particular limit. This paper explores the use of CA limit regulators using a publicly available commercial aircraft engine simulation. The improvement in thrust response while maintaining all necessary safety limits is demonstrated in a number of cases.

  7. The effect of soy isoflavones on the development of intestinal neoplasia in Apc(Min) mouse

    DEFF Research Database (Denmark)

    Sørensen, Ilona Kryspin; Kristiansen, Eva; Mortensen, Alicja

    1998-01-01

    Data from epidemiological studies suggest that isoflavones in soy may have a protective effect on the development of colon cancer in humans. Therefore, we have investigated whether soy isoflavones will inhibit intestinal tumour development in Apc(Min) mice. The mice were fed a Western-type high...... risk diet (high fat, low fibre and calcium) containing two different isolates of soy protein as a protein source. For the control and test groups this resulted in the administration of about 16 and 475 mg of total isoflavones per kg diet, respectively. As a positive control, a third group of mice...... was administered a low isoflavone diet supplemented with 300 ppm sulindac. No significant differences in the incidence, multiplicity, size and distribution of intestinal tumours were observed between Min mice fed low and high isoflavone-containing diets. However, a clear reduction in the number of small intestinal...

  8. Rapid Multiplex Small DNA Sequencing on the MinION Nanopore Sequencing Platform

    Directory of Open Access Journals (Sweden)

    Shan Wei

    2018-05-01

    Full Text Available Real-time sequencing of short DNA reads has a wide variety of clinical and research applications including screening for mutations, target sequences and aneuploidy. We recently demonstrated that MinION, a nanopore-based DNA sequencing device the size of a USB drive, could be used for short-read DNA sequencing. In this study, an ultra-rapid multiplex library preparation and sequencing method for the MinION is presented and applied to accurately test normal diploid and aneuploidy samples’ genomic DNA in under three hours, including library preparation and sequencing. This novel method shows great promise as a clinical diagnostic test for applications requiring rapid short-read DNA sequencing.

  9. Laypersons may learn basic life support in 24min using a personal resuscitation manikin

    DEFF Research Database (Denmark)

    Isbye, Dan Lou; Rasmussen, Lars Simon; Lippert, Freddy Knudsen

    2006-01-01

    -training. The second group attended a conventional 6 h BLS course (6 HR). After 3 months BLS skills were assessed on a Laerdal ResusciAnne manikin using the Laerdal PC Skill reporting System, and a total score was calculated. RESULTS: There was no significant difference between groups in BLS performance using...... assessed after 3 months, a 24 min DVD-based instruction plus subsequent self-training in BLS appears equally effective compared to a 6h BLS course and hence is more efficient. Udgivelsesdato: 2006-Jun...... and the challenge is to find the most efficient one. AIMS: To compare the efficiency of a 24 min instruction using a DVD-based self-training BLS course combined with a simple, take-home resuscitation manikin to a conventional 6h course for teaching BLS to laypersons. METHODS: In total, 238 laypersons (age 21...

  10. New EB curing system for narrow web, using Min-EB

    International Nuclear Information System (INIS)

    Nakamura, Tetsuhisa; Tominaga, Hiroshi; Oizumi, Kei

    2003-01-01

    We, TOYO INK, developed the new equipment of EB curing system for narrow web composed of vacuum tube-type electron beam irradiation apparatus called Min-EB which is specialized with ultra-low voltage, 50-60 KV, and not damaging against the substrate. The new development is very small size, 66 cm width, 64 cm depth, 80 cm height and convenient to install into printing and coating machines. Several tubes, Min-EB, are assembled to be multi-tube module, called MTM, to easily handle. Basically we can change the irradiation width and printing and coating speed by increasing MTM due to the sheet size and printing and coating condition. We got good results, showing high density for the printed film, after used new EB curing system. (author)

  11. Implementation of Layered Decoding Architecture for LDPC Code using Layered Min-Sum Algorithm

    OpenAIRE

    Sandeep Kakde; Atish Khobragade; Shrikant Ambatkar; Pranay Nandanwar

    2017-01-01

    For binary field and long code lengths, Low Density Parity Check (LDPC) code approaches Shannon limit performance. LDPC codes provide remarkable error correction performance and therefore enlarge the design space for communication systems.In this paper, we have compare different digital modulation techniques and found that BPSK modulation technique is better than other modulation techniques in terms of BER. It also gives error performance of LDPC decoder over AWGN channel using Min-Sum algori...

  12. Direct measurements of the 160.01-min oscillation in the solar radio brightness

    International Nuclear Information System (INIS)

    Efanov, V.A.; Moiseev, I.G.; Nesterov, N.S.

    1983-01-01

    Direct (nondifferential) brightness measurements of the quiet sun at lambda = 8.2 and 13.5 mm, corrected by the Bouguer law for absorption in the terrestrial atmosphere, confirm the presence of a 160.009 +- 0.002 min periodicity. At the two wavelengths the relative amplitudes are roughly-equal0.6 x 10 -3 , 1 x 10 -3 . Maximum radio brightness occurs at the phase when optical data indicate the photosphere radius is largest

  13. Acute Oxidative Effect and Muscle Damage after a Maximum 4 Min Test in High Performance Athletes.

    Directory of Open Access Journals (Sweden)

    Heros Ribeiro Ferreira

    Full Text Available The purpose of this investigation was to determine lipid peroxidation markers, physiological stress and muscle damage in elite kayakers in response to a maximum 4-min kayak ergometer test (KE test, and possible correlations with individual 1000m kayaking performances. The sample consisted of twenty-three adult male and nine adult female elite kayakers, with more than three years' experience in international events, who voluntarily took part in this study. The subjects performed a 10-min warm-up, followed by a 2-min passive interval, before starting the test itself, which consisted of a maximum 4-min work paddling on an ergometer; right after the end of the test, an 8 ml blood sample was collected for analysis. 72 hours after the test, all athletes took part in an official race, when then it was possible to check their performance in the on site K1 1000m test (P1000m. The results showed that all lipoproteins and hematological parameters tested presented a significant difference (p≤0.05 after exercise for both genders. In addition, parameters related to muscle damage such as lactate dehydrogenase (LDH and creatine kinase (CK presented significant differences after stress. Uric acid presented an inverse correlation with the performance (r = -0.76, while CK presented a positive correlation (r = 0.46 with it. Based on these results, it was possible to verify muscle damage and the level of oxidative stress caused by indoor training with specific ergometers for speed kayaking, highlighting the importance of analyzing and getting to know the physiological responses to this type of training, in order to provide information to coaches and optimize athletic performance.

  14. Etude physico-chimique et minéralogique comparative des ...

    African Journals Online (AJOL)

    La valorisation des ressources locales constitue un impératif afin d'atteindre des objectifs de développement durable. Cette étude a consisté à évaluer les caractéristiques physiques, chimiques et minéralogiques d'une argile provenant de Mbodiène (Sénégal), l'attapulgite, comparativement avec un médicament ...

  15. The chloroplast min system functions differentially in two specific nongreen plastids in Arabidopsis thaliana.

    Science.gov (United States)

    Wang, Peng; Zhang, Jie; Su, Jianbin; Wang, Peng; Liu, Jun; Liu, Bing; Feng, Dongru; Wang, Jinfa; Wang, Hongbin

    2013-01-01

    The nongreen plastids, such as etioplasts, chromoplasts, etc., as well as chloroplasts, are all derived from proplastids in the meristem. To date, the Min system members in plants have been identified as regulators of FtsZ-ring placement, which are essential for the symmetrical division of chloroplasts. However, the regulation of FtsZ-ring placement in nongreen plastids is poorly understood. In this study, we investigated the division site placement of nongreen plastids by examining the etioplasts as representative in Arabidopsis Min system mutants. Surprisingly, the shape and number of etioplasts in cotyledons of arc3, arc11 and mcd1 mutants were similar to that observed in wild-type plants, whereas arc12 and parc6 mutants exhibited enlarged etioplasts that were reduced in number. In order to examine nongreen plastids in true leaves, we silenced the ALB3 gene in these Min system mutant backgrounds to produce immature chloroplasts without the thylakoidal network using virus induced gene silencing (VIGS). Interestingly, consistent with our observations in etioplasts, enlarged and fewer nongreen plastids were only detected in leaves of parc6 (VIGS-ALB3) and arc12 (VIGS-ALB3) plants. Further, the FtsZ-ring assembled properly at the midpoint in nongreen plastids of arc3, arc11 and mcd1 (VIGS-ALB3) plants, but organized into multiple rings in parc6 (VIGS-ALB3) and presented fragmented filaments in arc12 (VIGS-ALB3) plants, suggesting that division site placement in nongreen plastids requires fewer components of the plant Min system. Taken together, these results suggest that division site placement in nongreen plastids is different from that in chloroplasts.

  16. The chloroplast min system functions differentially in two specific nongreen plastids in Arabidopsis thaliana.

    Directory of Open Access Journals (Sweden)

    Peng Wang

    Full Text Available The nongreen plastids, such as etioplasts, chromoplasts, etc., as well as chloroplasts, are all derived from proplastids in the meristem. To date, the Min system members in plants have been identified as regulators of FtsZ-ring placement, which are essential for the symmetrical division of chloroplasts. However, the regulation of FtsZ-ring placement in nongreen plastids is poorly understood. In this study, we investigated the division site placement of nongreen plastids by examining the etioplasts as representative in Arabidopsis Min system mutants. Surprisingly, the shape and number of etioplasts in cotyledons of arc3, arc11 and mcd1 mutants were similar to that observed in wild-type plants, whereas arc12 and parc6 mutants exhibited enlarged etioplasts that were reduced in number. In order to examine nongreen plastids in true leaves, we silenced the ALB3 gene in these Min system mutant backgrounds to produce immature chloroplasts without the thylakoidal network using virus induced gene silencing (VIGS. Interestingly, consistent with our observations in etioplasts, enlarged and fewer nongreen plastids were only detected in leaves of parc6 (VIGS-ALB3 and arc12 (VIGS-ALB3 plants. Further, the FtsZ-ring assembled properly at the midpoint in nongreen plastids of arc3, arc11 and mcd1 (VIGS-ALB3 plants, but organized into multiple rings in parc6 (VIGS-ALB3 and presented fragmented filaments in arc12 (VIGS-ALB3 plants, suggesting that division site placement in nongreen plastids requires fewer components of the plant Min system. Taken together, these results suggest that division site placement in nongreen plastids is different from that in chloroplasts.

  17. The new 157Tm isotope, Tsub(1/2)=(3.6+-0.3) min

    International Nuclear Information System (INIS)

    Latuszynski, A.; Mikulski, J.; Potempa, A.W.; Zielinski, A.; Zuber, K.; Penev, I.; Zuber, J.

    1975-01-01

    The new isotope 157 Tm was discovered, and its half-life Tsub(1/2) (3.6+-0.3)min was measured. On the basis of the balance of energies and intensities of γ-transitions occurring in the 157 Tm decay a number of excited states of the 157 Er nucleus with energies of 110.2; 241.3; 357.3 and 457.1 keV were found. (author)

  18. Fabrication of a cantilever-based microfluidic flow meter with nL min(-1) resolution

    DEFF Research Database (Denmark)

    Noeth, Nadine-Nicole; Keller, Stephan Sylvest; Boisen, Anja

    2011-01-01

    A microfluidic flow meter based on cantilever deflection is developed, showing a resolution down to 3 nL min(-1) for flows in the microliter range. The cantilevers are fabricated in SU-8 and have integrated holes with dimensions from 5 x 5 to20x 20 mu m(2). The holes make it possible to measure i......, hole-to-hole distance, amount of holes, etc) the sensitivity of the sensor can be changed....

  19. Constrained Balancing of Two Industrial Rotor Systems: Least Squares and Min-Max Approaches

    Directory of Open Access Journals (Sweden)

    Bin Huang

    2009-01-01

    Full Text Available Rotor vibrations caused by rotor mass unbalance distributions are a major source of maintenance problems in high-speed rotating machinery. Minimizing this vibration by balancing under practical constraints is quite important to industry. This paper considers balancing of two large industrial rotor systems by constrained least squares and min-max balancing methods. In current industrial practice, the weighted least squares method has been utilized to minimize rotor vibrations for many years. One of its disadvantages is that it cannot guarantee that the maximum value of vibration is below a specified value. To achieve better balancing performance, the min-max balancing method utilizing the Second Order Cone Programming (SOCP with the maximum correction weight constraint, the maximum residual response constraint as well as the weight splitting constraint has been utilized for effective balancing. The min-max balancing method can guarantee a maximum residual vibration value below an optimum value and is shown by simulation to significantly outperform the weighted least squares method.

  20. X-Ray Diffraction on Mars: Scientific Discoveries Made by the CheMin Instrument

    Science.gov (United States)

    Rampe, E. B.; Blake, D. F.; Ming, D. W.; Bristow, T. F.

    2017-01-01

    The Mars Science Laboratory Curiosity landed in Gale crater in August 2012 with the goal to identify and characterize habitable environments on Mars. Curiosity has been studying a series of sedimentary rocks primarily deposited in fluviolacustrine environments approximately 3.5 Ga. Minerals in the rocks and soils on Mars can help place further constraints on these ancient aqueous environments, including pH, salinity, and relative duration of liquid water. The Chemistry and Mineralogy (CheMin) X-ray diffraction and X-ray fluorescence instrument on Curiosity uses a Co X-ray source and charge-coupled device detector in transmission geometry to collect 2D Debye-Scherrer ring patterns of the less than 150 micron size fraction of drilled rock powders or scooped sediments. With an angular range of approximately 2.52deg 20 and a 20 resolution of approximately 0.3deg, mineral abundances can be quantified with a detection limit of approximately 1-2 wt. %. CheMin has returned quantitative mineral abundances from 16 mudstone, sandstone, and aeolian sand samples so far. The mineralogy of these samples is incredibly diverse, suggesting a variety of depositional and diagenetic environments and different source regions for the sediments. Results from CheMin have been essential for reconstructing the geologic history of Gale crater and addressing the question of habitability on ancient Mars.

  1. The food processing contaminant glyoxal promotes tumour growth in the multiple intestinal neoplasia (Min) mouse model.

    Science.gov (United States)

    Svendsen, Camilla; Høie, Anja Hortemo; Alexander, Jan; Murkovic, Michael; Husøy, Trine

    2016-08-01

    Glyoxal is formed endogenously and at a higher rate in the case of hyperglycemia. Glyoxal is also a food processing contaminant and has been shown to be mutagenic and genotoxic in vitro. The tumourigenic potential of glyoxal was investigated using the multiple intestinal neoplasia (Min) mouse model, which spontaneously develops intestinal tumours and is susceptible to intestinal carcinogens. C57BL/6J females were mated with Min males. Four days after mating and throughout gestation and lactation, the pregnant dams were exposed to glyoxal through drinking water (0.0125%, 0.025%, 0.05%, 0.1%) or regular tap water. Female and male offspring were housed separately from PND21 and continued with the same treatment. One group were only exposed to 0.1% glyoxal from postnatal day (PND) 21. There was no difference in the number of intestinal tumours between control and treatment groups. However, exposure to 0.1% glyoxal starting in utero and at PND21 caused a significant increase in tumour size in the small intestine for male and female mice in comparison with respective control groups. This study suggests that glyoxal has tumour growth promoting properties in the small intestine in Min mice. Copyright © 2016 Norwegian Institute of Public Health. Published by Elsevier Ltd.. All rights reserved.

  2. Signaling-Free Max-Min Airtime Fairness in IEEE 802.11 Ad Hoc Networks

    Directory of Open Access Journals (Sweden)

    Youngsoo Lee

    2016-01-01

    Full Text Available We propose a novel media access control (MAC protocol, referred to as signaling-free max-min airtime fair (SMAF MAC, to improve fairness and channel utilization in ad hoc networks based on IEEE 802.11 wireless local area networks (WLANs. We introduce busy time ratio (BTR as a measure for max-min airtime fairness. Each node estimates its BTR and adjusts the transmission duration by means of frame aggregation and fragmentation, so that it can implicitly announce the BTR to neighbor nodes. Based on the announced BTR, each of the neighbor nodes controls its contention window. In this way, the SMAF MAC works in a distributed manner without the need to know the max-min fair share of airtime, and it does not require exchanging explicit control messages among nodes to attain fairness. Moreover, we successfully incorporate the hidden node detection and resolution mechanisms into the SMAF MAC to deal with the hidden node problem in ad hoc networks. The simulation results confirm that the SMAF MAC enhances airtime fairness without degrading channel utilization, and it effectively resolves several serious problems in ad hoc networks such as the starvation, performance anomaly, and hidden node problems.

  3. Naringin, a natural dietary compound, prevents intestinal tumorigenesis in Apc (Min/+) mouse model.

    Science.gov (United States)

    Zhang, Yu-Sheng; Li, Ye; Wang, Yan; Sun, Shi-Yue; Jiang, Tao; Li, Cong; Cui, Shu-Xiang; Qu, Xian-Jun

    2016-05-01

    Naringin is a natural dietary flavonoid compound. We aimed to evaluate the effects of naringin on intestinal tumorigenesis in the adenomatous polyposis coli multiple intestinal neoplasia (Apc (Min/+)) mouse model. Apc (Min/+) mice were given either naringin (150 mg/kg) or vehicle by p.o. gavage daily for 12 consecutive weeks. Mice were killed with ether, and blood samples were collected to assess the concentrations of IL-6 and PGE2. Total intestines were removed, and the number of polyps was examined. Tissue samples of intestinal polyps were subjected to the assays of histopathology, immunohistochemical analysis and Western blotting analysis. Apc (Min/+) mice fed with naringin developed less and smaller polyps in total intestines. Naringin prevented intestinal tumorigenesis without adverse effects. Histopathologic analysis revealed the reduction of dysplastic cells and dysplasia in the adenomatous polyps. The treatments' effects might arise from its anti-proliferation, induction of apoptosis and modulation of GSK-3β and APC/β-catenin signaling pathways. Naringin also exerted its effects on tumorigenesis through anti-chronic inflammation. Naringin prevented intestinal tumorigenesis likely through a collection of activities including anti-proliferation, induction of apoptosis, modulation of GSK-3β and APC/β-catenin pathways and anti-inflammation. Naringin is a potential chemopreventive agent for reducing the risk of colonic cancers.

  4. Caffeine, but not bicarbonate, improves 6 min maximal performance in elite rowers.

    Science.gov (United States)

    Christensen, Peter M; Petersen, Mads H; Friis, Signe N; Bangsbo, Jens

    2014-09-01

    This study examined the ergogenic effects in a 6 min maximal performance test (PT) on 12 elite rowers: 6 open-weight (mean ± SD; 25 ± 1 years, and 92 ± 3 kg) and 6 light-weight (25 ± 3 years, and 73 ± 6 kg), following supplementation with caffeine (CAF), sodium bicarbonate (SB), and the combination of both, in a double-blind randomized placebo (PLA) controlled design. PT was executed on 4 occasions, on separate days within a week, and in a non-fasted state, with standardized training being performed the day before PT. Protocols were as follows: (i) CAF, 3 mg/kg, 45 min prior to PT + calcium as SB-PLA; (ii) SB, 0.3 g/kg, 75 min prior to PT + dextrose as CAF-PLA; (iii) CAF + SB; and (iv) PLA; CAF-PLA + SB-PLA. The total distance in the CAF (1878 ± 97 m) and CAF + SB (1877 ± 97 m) was longer than in the PLA (1865 ± 104 m; P 0.05). No difference between interventions was observed for readiness and stomach comfort before PT and perceived exertion during PT. This study demonstrates that caffeine ingestion does improve performance in elite rowing. In contrast sodium bicarbonate does not appear to be ergogenic, but it does not abolish the ergogenic effect of caffeine.

  5. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Pulmonology”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Pulmonology”ABS 1. URINE NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN AS A MARKER OF BRONCHOPULMONARY DYSPLASIA AND RETINOPATHY OF PREMATURITY IN PRETERM NEONATES • H. Ergin, T. Atilgan, M. Dogan, O.M.A. Ozdemir, C. YeniseyABS 2. LUNG COMPLIANCE AND LUNG ULTRASOUND DURING POSTNATAL ADAPTATION IN HEALTHY NEWBORN INFANTS • L. Süvari, L. Martelius, C. Janér, A. Kaskinen, O. Pitkänen, T. Kirjavainen, O. Helve, S. AnderssonABS 3. PRE-DISCHARGE RESPIRATORY OUTCOMES IN SMALL-FOR-GESTATIONAL-AGE AND APPROPRIATE-FOR-GESTATIONAL-AGE VERY PRETERM INFANTS • A. Matic, A. RistivojevicABS 4. THE EFFECT OF CHANGING OXYGEN SATURATION TARGET RANGE ON COMPLIANCE IN OXYGEN SATURATION TARGETING IN THE NEONATAL INTENSIVE CARE UNIT • H.A. van Zanten, S. Pauws, E.C.H. Beks, B.J. Stenson, E. Lopriore, A.B. te PasABS 5. BINASAL PRONG VERSUS NASAL MASK FOR APPLYING CPAP TO PRETERM INFANTS: RANDOMIZED CONTROLLED TRIAL • B. Say, G. Kanmaz, S.S. OguzABS 6. TRAINING AND RAISING AWARENESS IMPROVES COMPLIANCE IN OXYGEN SATURATION TARGETING IN THE NEONATAL INTENSIVE CARE UNIT • H.A. van Zanten, S. Pauws, E.C.H. Beks, B.J. Stenson, E

  6. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Other”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Other”ABS 1. TELEMEDICINE IN NEONATAL HOMECARE • K.G. Holm, A. Brodsgaard, G. Zachariassen, J. ClemensenABS 2. ACCEPTABILITY OF PARENT REPORT QUESTIONNAIRES FOR ROUTINE FOLLOW-UP IN LATE/MODERATELY PRETERM INFANTS • N. Armstrong, S. Johnson, E.M. BoyleABS 3. INTERNATIONAL CARE PRACTICES AROUND AN INFANT’S DEATH IN THE NICU; A SURVEY STUDY • C.M.C. van den Berg, K. Alferink, J.M. Latour, N. Valkenburg, M. van DijkABS 4. ANXIETY AND DEPRESSION OVER TIME, IN MOTHERS OF VERY PRETERM BORN CHILDREN • M. Jeukens-Visser, M. Husson, D. Meijssen, M. Flierman, P. van Schie, K. Koldewijn, A. Wassenaer-van LeemhuisABS 5. LONGITUDINAL CHANGE OF HEALTH-RELATED QUALITY OF LIFE EXPERIENCED OVER TIME BY MOTHER WITH LATE PRETERM INFANT • L.Y. Tsai, S.C. Mu, Y.L. Chen, Y.L. Guo, P.C. ChenABS 6. RELATIONSHIP BETWEEN ANXIETY LEVELS AND CLINICAL PRACTICE SKILLS AMONG STUDENTS OF PEDIATRIC NURSING LECTURE • A.S. Kurt, F.T. Arslan, S. Özkan, R. Çelen, D.A. ÇakırABS 7. ACCURACY OF SMARTPHONES FOR REVIEWING TRANSMITTED IMAGES OF NEONATAL X-RAYS • T. Vasko, M. Westberg, J.A. Dawson, L.S. Owen, M. Thio, R. Bhatia, S. Donath

  7. The max–min ant system and tabu search for pressurized water reactor loading pattern design

    International Nuclear Information System (INIS)

    Lin, Chaung; Chen, Ying-Hsiu

    2014-01-01

    Highlights: • An automatic loading pattern design tool for a pressurized water reactor is developed. • The design method consists of max–min ant system and tabu search. • The heuristic rules are developed to generate the candidates for tabu search. • The initial solution of tabu search is provided by max–min ant system. • The new algorithm shows very satisfactory results compared to the old one. - Abstract: An automatic loading pattern (LP) design tool for a pressurized water reactor is developed. The design procedure consists of two steps: first, a LP is generated using max–min ant system (MMAS) and then tabu search (TS) is adopted to search the satisfactory LP. The MMAS is previously developed and the TS process is newly-developed. The heuristic rules are implemented to generate the candidate LP in TS process. The heuristic rules are comprised of two kinds of action, i.e., a single swap in the location of two fuel assemblies and rotation of fuel assembly. Since developed TS process is a local search algorithm, it is efficient for the minor change of LP. It means that a proper initial LP should be provided by the first step, i.e., by MMAS. The design requirements such as hot channel factor, the hot zero power moderator temperature coefficient, and cycle length are formulated in the objective function. The results show that the developed tool can obtain the satisfactory LP and dramatically reduce the computation time compared with previous tool using ant system alone

  8. Detection of solar radio brightness oscillations with 160.01-min period from direct measurements

    International Nuclear Information System (INIS)

    Efanov, V.A.; Moiseev, I.G.; Nesterov, N.S.

    1983-01-01

    It is shown that direct measurements of the quiet Sun brightness at 8.2 and 13.5 mm wavelengths corrected for extinction in the Earth atmosphere by means of the Bouguer law reveal the 160.01-min periodic component. The relative amplitudes of variations are of approximately 6x10 -4 at the shorter wavelength and of 10 -3 at the longer one. The brightness maximum coincides with the phase of the maximal radius of the photosphere as derived from the optical data

  9. Liver Inflammation and Metabolic Signaling in ApcMin/+ Mice: The Role of Cachexia Progression

    Science.gov (United States)

    Narsale, Aditi A.; Enos, Reilly T.; Puppa, Melissa J.; Chatterjee, Saurabh; Murphy, E. Angela; Fayad, Raja; Pena, Majorette O’; Durstine, J. Larry; Carson, James A.

    2015-01-01

    The ApcMin/+ mouse exhibits an intestinal tumor associated loss of muscle and fat that is accompanied by chronic inflammation, insulin resistance and hyperlipidemia. Since the liver governs systemic energy demands through regulation of glucose and lipid metabolism, it is likely that the liver is a pathological target of cachexia progression in the ApcMin/+ mouse. The purpose of this study was to determine if cancer and the progression of cachexia affected liver endoplasmic reticulum (ER)-stress, inflammation, metabolism, and protein synthesis signaling. The effect of cancer (without cachexia) was examined in wild-type and weight-stable ApcMin/+ mice. Cachexia progression was examined in weight-stable, pre-cachectic, and severely-cachectic ApcMin/+ mice. Livers were analyzed for morphology, glycogen content, ER-stress, inflammation, and metabolic changes. Cancer induced hepatic expression of ER-stress markers BiP (binding immunoglobulin protein), IRE-1α (endoplasmic reticulum to nucleus signaling 1), and inflammatory intermediate STAT-3 (signal transducer and activator of transcription 3). While gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK) mRNA expression was suppressed by cancer, glycogen content or protein synthesis signaling remained unaffected. Cachexia progression depleted liver glycogen content and increased mRNA expression of glycolytic enzyme PFK (phosphofrucktokinase) and gluconeogenic enzyme PEPCK. Cachexia progression further increased pSTAT-3 but suppressed p-65 and JNK (c-Jun NH2-terminal kinase) activation. Interestingly, progression of cachexia suppressed upstream ER-stress markers BiP and IRE-1α, while inducing its downstream target CHOP (DNA-damage inducible transcript 3). Cachectic mice exhibited a dysregulation of protein synthesis signaling, with an induction of p-mTOR (mechanistic target of rapamycin), despite a suppression of Akt (thymoma viral proto-oncogene 1) and S6 (ribosomal protein S6) phosphorylation. Thus, cancer

  10. Preparation of {sup 114m}In low energy conversion electron sources

    Energy Technology Data Exchange (ETDEWEB)

    Wrede, C., E-mail: wrede@uw.ed [Center for Experimental Nuclear Physics and Astrophysics, and Department of Physics, University of Washington, Seattle, WA 98195 (United States); Filippone, B.W. [Kellogg Radiation Laboratory, California Institute of Technology, Pasadena, California 91125 (United States); Garcia, A.; Harper, G.C. [Center for Experimental Nuclear Physics and Astrophysics, and Department of Physics, University of Washington, Seattle, WA 98195 (United States); Lassell, S. [Department of Nuclear Engineering, North Carolina State University, Raleigh, North Carolina 27695 (United States); Liu, J. [Kellogg Radiation Laboratory, California Institute of Technology, Pasadena, California 91125 (United States); Department of Physics, Shanghai Jiao Tong University, Shanghai 200240 (China); Mendenhall, M.P. [Kellogg Radiation Laboratory, California Institute of Technology, Pasadena, California 91125 (United States); Palmer, A.S.C. [Center for Experimental Nuclear Physics and Astrophysics, and Department of Physics, University of Washington, Seattle, WA 98195 (United States); Pattie, R.W. [Department of Physics, North Carolina State University, Raleigh, North Carolina 27695 (United States); Will, D.I. [Center for Experimental Nuclear Physics and Astrophysics, and Department of Physics, University of Washington, Seattle, WA 98195 (United States); Young, A.R. [Department of Physics, North Carolina State University, Raleigh, North Carolina 27695 (United States)

    2011-05-15

    Highlights: {yields} Controlled ion implantation of In-113 into thin Al substrate. {yields} Production of In-114m (half life = 50 days) by neutron irradiation. {yields} Use of In-114m as a source of electron lines and continuum for calibrations. {yields} Source reactivation by short neutron irradiation. -- Abstract: The preparation of {sup 114m}In sources of conversion electrons in the energy range 162-190 keV and {beta} continuum with a 1989 keV endpoint via ion implantation of {sup 113}In into Al substrates and subsequent irradiation by thermal and epi-thermal neutrons in a nuclear reactor is described.

  11. Liver inflammation and metabolic signaling in ApcMin/+ mice: the role of cachexia progression.

    Directory of Open Access Journals (Sweden)

    Aditi A Narsale

    Full Text Available The ApcMin/+ mouse exhibits an intestinal tumor associated loss of muscle and fat that is accompanied by chronic inflammation, insulin resistance and hyperlipidemia. Since the liver governs systemic energy demands through regulation of glucose and lipid metabolism, it is likely that the liver is a pathological target of cachexia progression in the ApcMin/+ mouse. The purpose of this study was to determine if cancer and the progression of cachexia affected liver endoplasmic reticulum (ER-stress, inflammation, metabolism, and protein synthesis signaling. The effect of cancer (without cachexia was examined in wild-type and weight-stable ApcMin/+ mice. Cachexia progression was examined in weight-stable, pre-cachectic, and severely-cachectic ApcMin/+ mice. Livers were analyzed for morphology, glycogen content, ER-stress, inflammation, and metabolic changes. Cancer induced hepatic expression of ER-stress markers BiP (binding immunoglobulin protein, IRE-1α (endoplasmic reticulum to nucleus signaling 1, and inflammatory intermediate STAT-3 (signal transducer and activator of transcription 3. While gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK mRNA expression was suppressed by cancer, glycogen content or protein synthesis signaling remained unaffected. Cachexia progression depleted liver glycogen content and increased mRNA expression of glycolytic enzyme PFK (phosphofrucktokinase and gluconeogenic enzyme PEPCK. Cachexia progression further increased pSTAT-3 but suppressed p-65 and JNK (c-Jun NH2-terminal kinase activation. Interestingly, progression of cachexia suppressed upstream ER-stress markers BiP and IRE-1α, while inducing its downstream target CHOP (DNA-damage inducible transcript 3. Cachectic mice exhibited a dysregulation of protein synthesis signaling, with an induction of p-mTOR (mechanistic target of rapamycin, despite a suppression of Akt (thymoma viral proto-oncogene 1 and S6 (ribosomal protein S6 phosphorylation. Thus

  12. MinION™ nanopore sequencing of environmental metagenomes: a synthetic approach.

    Science.gov (United States)

    Brown, Bonnie L; Watson, Mick; Minot, Samuel S; Rivera, Maria C; Franklin, Rima B

    2017-03-01

    Environmental metagenomic analysis is typically accomplished by assigning taxonomy and/or function from whole genome sequencing or 16S amplicon sequences. Both of these approaches are limited, however, by read length, among other technical and biological factors. A nanopore-based sequencing platform, MinION™, produces reads that are ≥1 × 104 bp in length, potentially providing for more precise assignment, thereby alleviating some of the limitations inherent in determining metagenome composition from short reads. We tested the ability of sequence data produced by MinION (R7.3 flow cells) to correctly assign taxonomy in single bacterial species runs and in three types of low-complexity synthetic communities: a mixture of DNA using equal mass from four species, a community with one relatively rare (1%) and three abundant (33% each) components, and a mixture of genomic DNA from 20 bacterial strains of staggered representation. Taxonomic composition of the low-complexity communities was assessed by analyzing the MinION sequence data with three different bioinformatic approaches: Kraken, MG-RAST, and One Codex. Results: Long read sequences generated from libraries prepared from single strains using the version 5 kit and chemistry, run on the original MinION device, yielded as few as 224 to as many as 3497 bidirectional high-quality (2D) reads with an average overall study length of 6000 bp. For the single-strain analyses, assignment of reads to the correct genus by different methods ranged from 53.1% to 99.5%, assignment to the correct species ranged from 23.9% to 99.5%, and the majority of misassigned reads were to closely related organisms. A synthetic metagenome sequenced with the same setup yielded 714 high quality 2D reads of approximately 5500 bp that were up to 98% correctly assigned to the species level. Synthetic metagenome MinION libraries generated using version 6 kit and chemistry yielded from 899 to 3497 2D reads with lengths averaging 5700 bp with up

  13. New bound on MIS and MIN-CDS for a unit ball graph

    Directory of Open Access Journals (Sweden)

    D.A. Mojdeh

    2017-09-01

    Full Text Available The size of the maximum independent set (MIS in a graph G is called the independence number. The size of the minimum connected dominating set (MIN-CDS in G is called the connected domination number. The aim of this paper is to determine two better upper bounds of the independence number; dependent on the connected domination number for a unit ball graph. Further, we improve the upper bound to obtain the best bound with respect to the upper bounds obtained thus far.

  14. Caffeine, but not bicarbonate, improves 6 min maximal performance in elite rowers

    DEFF Research Database (Denmark)

    Christensen, Peter Møller; Petersen, Mads H; Friis, Signe N

    2014-01-01

    This study examined the ergogenic effects in a 6 min maximal performance test (PT) on 12 elite rowers: 6 open-weight (mean ± SD; 25 ± 1 years, and 92 ± 3 kg) and 6 light-weight (25 ± 3 years, and 73 ± 6 kg), following supplementation with caffeine (CAF), sodium bicarbonate (SB), and the combination.......05) than in open-weight rowers (0.3% ± 0.8%; P > 0.05). No difference between interventions was observed for readiness and stomach comfort before PT and perceived exertion during PT. This study demonstrates that caffeine ingestion does improve performance in elite rowing. In contrast sodium bicarbonate...

  15. Implementation of Layered Decoding Architecture for LDPC Code using Layered Min-Sum Algorithm

    Directory of Open Access Journals (Sweden)

    Sandeep Kakde

    2017-12-01

    Full Text Available For binary field and long code lengths, Low Density Parity Check (LDPC code approaches Shannon limit performance. LDPC codes provide remarkable error correction performance and therefore enlarge the design space for communication systems.In this paper, we have compare different digital modulation techniques and found that BPSK modulation technique is better than other modulation techniques in terms of BER. It also gives error performance of LDPC decoder over AWGN channel using Min-Sum algorithm. VLSI Architecture is proposed which uses the value re-use property of min-sum algorithm and gives high throughput. The proposed work has been implemented and tested on Xilinx Virtex 5 FPGA. The MATLAB result of LDPC decoder for low bit error rate (BER gives bit error rate in the range of 10-1 to 10-3.5 at SNR=1 to 2 for 20 no of iterations. So it gives good bit error rate performance. The latency of the parallel design of LDPC decoder has also reduced. It has accomplished 141.22 MHz maximum frequency and throughput of 2.02 Gbps while consuming less area of the design.

  16. Intestinal microbiota: a potential diet-responsive prevention target in ApcMin mice.

    Science.gov (United States)

    Mai, Volker; Colbert, Lisa H; Perkins, Susan N; Schatzkin, Arthur; Hursting, Stephen D

    2007-01-01

    We previously reported that two dietary regimens, calorie restriction (CR) and a high olive oil-containing diet supplemented with a freeze-dried fruit and vegetable extract (OFV), reduced the development of intestinal adenomas in Apc(Min) mice by 57% and 33%, respectively, compared to control mice fed a defined diet ad libitum. The OFV diet was designed to have a strong effect on the composition of the intestinal microbiota through its high content of fiber, which represents a major source of fermentable substrate for the gut bacteria. We hypothesized that some of the observed effects of diet on intestinal carcinogenesis might be mediated by diet-related changes in the bacterial species that thrive in the gut. Therefore, we determined by fluorescent in situ hybridization (FISH) and denaturing gradient gel electrophoresis (DGGE) how the dietary interventions affected the composition of the intestinal microbiota, and we characterized specific microbiota changes that were associated with diet and reduced intestinal carcinogenesis. The OFV diet changed the overall composition of the intestinal microbiota, smaller changes were observed for the CR diet. Furthermore, we detected a 16S rDNA fragment associated with mice that did not develop polyps. Sequence analysis suggested that hitherto unidentified bacteria belonging to the family Lachnospiraceae (order Clostridiales) were its source. Thus, these bacteria may be an indicator of intestinal conditions associated with reduced intestinal carcinogenesis in Apc(Min) mice. Copyright 2006 Wiley-Liss, Inc.

  17. Illumination Tolerance for Visual Navigation with the Holistic Min-Warping Method

    Directory of Open Access Journals (Sweden)

    Ralf Möller

    2014-02-01

    Full Text Available Holistic visual navigation methods are an emerging alternative to the ubiquitous feature-based methods. Holistic methods match entire images pixel-wise instead of extracting and comparing local feature descriptors. In this paper we investigate which pixel-wise distance measures are most suitable for the holistic min-warping method with respect to illumination invariance. Two novel approaches are presented: tunable distance measures—weighted combinations of illumination-invariant and illumination-sensitive terms—and two novel forms of “sequential” correlation which are only invariant against intensity shifts but not against multiplicative changes. Navigation experiments on indoor image databases collected at the same locations but under different conditions of illumination demonstrate that tunable distance measures perform optimally by mixing their two portions instead of using the illumination-invariant term alone. Sequential correlation performs best among all tested methods, and as well but much faster in an approximated form. Mixing with an additional illumination-sensitive term is not necessary for sequential correlation. We show that min-warping with approximated sequential correlation can successfully be applied to visual navigation of cleaning robots.

  18. MinHash-Based Fuzzy Keyword Search of Encrypted Data across Multiple Cloud Servers

    Directory of Open Access Journals (Sweden)

    Jingsha He

    2018-05-01

    Full Text Available To enhance the efficiency of data searching, most data owners store their data files in different cloud servers in the form of cipher-text. Thus, efficient search using fuzzy keywords becomes a critical issue in such a cloud computing environment. This paper proposes a method that aims at improving the efficiency of cipher-text retrieval and lowering storage overhead for fuzzy keyword search. In contrast to traditional approaches, the proposed method can reduce the complexity of Min-Hash-based fuzzy keyword search by using Min-Hash fingerprints to avoid the need to construct the fuzzy keyword set. The method will utilize Jaccard similarity to rank the results of retrieval, thus reducing the amount of calculation for similarity and saving a lot of time and space overhead. The method will also take consideration of multiple user queries through re-encryption technology and update user permissions dynamically. Security analysis demonstrates that the method can provide better privacy preservation and experimental results show that efficiency of cipher-text using the proposed method can improve the retrieval time and lower storage overhead as well.

  19. Effects of hemin and nitrite on intestinal tumorigenesis in the A/J Min/+ mouse model.

    Directory of Open Access Journals (Sweden)

    Marianne Sødring

    Full Text Available Red and processed meats are considered risk factors for colorectal cancer (CRC; however, the underlying mechanisms are still unclear. One cause for the potential link between CRC and meat is the heme iron in red meat. Two pathways by which heme and CRC promotion may be linked have been suggested: fat peroxidation and N-nitrosation. In the present work we have used the novel A/J Min/+ mouse model to test the effects of dietary hemin (a model of red meat, and hemin in combination with nitrite (a model of processed meat on intestinal tumorigenesis. Mice were fed a low Ca2+ and vitamin D semi-synthetic diet with added hemin and/or nitrite for 8 weeks post weaning, before termination followed by excision and examination of the intestinal tract. Our results indicate that dietary hemin decreased the number of colonic lesions in the A/J Min/+ mouse. However, our results also showed that the opposite occurred in the small intestine, where dietary hemin appeared to stimulate tumor growth. Furthermore, we find that nitrite, which did not have an effect in the colon, appeared to have a suppressive effect on tumor growth in the small intestine.

  20. Influencing factors of the 6-min walk distance in adult Arab populations: a literature review.

    Science.gov (United States)

    Joobeur, Samah; Rouatbi, Sonia; Latiri, Imed; Sfaxi, Raoudha; Ben Saad, Helmi

    2016-05-01

    Background Walk tests, especially the 6-min walk-test (6MWT), are commonly used in order to evaluate submaximal exercise capacity. The primary outcome of the 6MWT is the 6-min walk-distance (6MWD). Numerous demographic, physiological and anthropometric factors can influence the 6MWD in healthy adults. Objective The purpose of the present review is to highlight and discuss the 6MWD influencing factors in healthy of the healthy adult Arab populations. Methods It is a review including a literature search, from 1970 to September 31th 2015 using the PubMed, the Science Direct databases and the World Wide Web on Google search engine. Reference lists of retrieved English/French articles were searched for any additional references. Results Six studies, conducted in Tunisia (n=2), Saudi Arabia (n=3) and Algeria (n=1) were included. All studies were conducted according to the 2002-American-thoracic-society guidelines for the 6MWT. In addition to anthropometric data (sex, age, height, weight, body mass index, lean mass), the following data were recognized as 6MWD influencing factors: schooling and socioeconomic levels, urban origin, parity, physical activity score or status, metabolic equivalent task for moderate activity, spirometric data, end-walk heart-rate, resting diastolic blood pressure, dyspnoea Borg value and niqab-wearing. Conclusion The 6MWD influencing factors in adult Arab populations are numerous and include some specific predictors such as parity, physical activity level and niqab-wearing.

  1. MinGenome: An In Silico Top-Down Approach for the Synthesis of Minimized Genomes.

    Science.gov (United States)

    Wang, Lin; Maranas, Costas D

    2018-02-16

    Genome minimized strains offer advantages as production chassis by reducing transcriptional cost, eliminating competing functions and limiting unwanted regulatory interactions. Existing approaches for identifying stretches of DNA to remove are largely ad hoc based on information on presumably dispensable regions through experimentally determined nonessential genes and comparative genomics. Here we introduce a versatile genome reduction algorithm MinGenome that implements a mixed-integer linear programming (MILP) algorithm to identify in size descending order all dispensable contiguous sequences without affecting the organism's growth or other desirable traits. Known essential genes or genes that cause significant fitness or performance loss can be flagged and their deletion can be prohibited. MinGenome also preserves needed transcription factors and promoter regions ensuring that retained genes will be properly transcribed while also avoiding the simultaneous deletion of synthetic lethal pairs. The potential benefit of removing even larger contiguous stretches of DNA if only one or two essential genes (to be reinserted elsewhere) are within the deleted sequence is explored. We applied the algorithm to design a minimized E. coli strain and found that we were able to recapitulate the long deletions identified in previous experimental studies and discover alternative combinations of deletions that have not yet been explored in vivo.

  2. Decay of mass-separated 187Au (8.4 min) to 187Pt

    International Nuclear Information System (INIS)

    Gnade, B.E.; Fink, R.W.; Wood, J.L.

    1983-01-01

    The decay of 187 Au to 187 Pt has been studied with mass-separated sources from the UNISOR facility. Multiscaled spectra of γ-rays, X-rays, and conversion electrons, as well as γγt, Xγt, eγt, and eXt coincidences were obtained. The half-life of the 187 Au ground state was measured to be 8.4 +- 0.3 min. A decay scheme has been constructed incorporating 88% of the decay intensity assigned to 187 Au. The isub(13/2) band in 187 Pt is populated through low-spin band members. The levels at 260 and 288 keV are found to de-excite by EO transitions. From a γ-ray-gated K/β + ratio, the β-decay energy of 8.4 min 187 Au is deduced to be Qsub(EC)=3.90 +- 0.15 MeV. The positive-parity states in 187 Pt are compared with calculations made using the Nilsson model with a triaxial degree of freedom. The possibility that shape coexistence is present at low energy in 187 Pt is discussed. (orig.)

  3. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Brain & Development”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Brain & Development”ABS 1. SEPARATE EFFECTS OF LOW PATERNAL AND MATERNAL EDUCATIONAL LEVEL ON RISK OF DEVELOPMENTAL DELAY IN 4-YEAR-OLD BOYS AND GIRLS • S. de Jong, M.R. Potijk, A.E. den Heijer, S.A. Reijneveld, A.F. Bos, J.M. KerstjensABS 2. THE ASSOCIATION BETWEEN PATERNAL EDUCATIONAL LEVEL AND DEVELOPMENTAL DELAY IN PRETERM AND TERM-BORN CHILDREN AT AGE 4 • S. de Jong, J.M. Kerstjens, A.E. den Heijer, A.F. Bos, S.A. Reijneveld, M.R. PotijkABS 3. NEUROPROTECTION BY NEURONAL OVEREXPRESSION OF THE SMALL GTPase-Ras IN HYPEROXIA-INDUCED NEONATAL BRAIN INJURY • M. Serdar, K. Kempe, J. Herz, R. Herrmann, B.S. Reinboth, R. Heumann, A. Ehrkamp, U. Felderhoff-Mueser, I. BendixABS 4. REFERENCE RANGES FOR CEREBRAL TISSUE OXYGEN INDEX (cTOI IN NEONATES DURING IMMEDIATE NEONATAL TRANSITION AFTER BIRTH • N. Baik, B. Urlesberger, B. Schwaberger, G. Schmölzer, A. Avian, L. Mileder, G. PichlerABS 4. REFERENCE RANGES FOR CEREBRAL TISSUE OXYGEN INDEX (cTOI IN NEONATES DURING IMMEDIATE NEONATAL TRANSITION AFTER BIRTH • N. Baik, B. Urlesberger, B. Schwaberger, G. Schmölzer, A. Avian, L. Mileder, G. PichlerABS 6. N

  4. Heart Rate Recovery After 6-Min Walk Test Predicts Survival in Patients With Idiopathic Pulmonary Fibrosis

    Science.gov (United States)

    Swigris, Jeffrey J.; Swick, Jeff; Wamboldt, Frederick S.; Sprunger, David; du Bois, Roland; Fischer, Aryeh; Cosgrove, Gregory P.; Frankel, Stephen K.; Fernandez-Perez, Evans R.; Kervitsky, Dolly; Brown, Kevin K.

    2009-01-01

    Background: In patients with idiopathic pulmonary fibrosis (IPF), our objectives were to identify predictors of abnormal heart rate recovery (HRR) at 1 min after completion of a 6-min walk test (6MWT) [HRR1] and 2 min after completion of a 6MWT (HRR2), and to determine whether abnormal HRR predicts mortality. Methods: From 2003 to 2008, we identified IPF patients who had been evaluated at our center (n = 76) with a pulmonary physiologic examination and the 6MWT. We used logistic regression to identify predictors of abnormal HRR, the product-limit method to compare survival in the sample stratified on HRR, and Cox proportional hazards analysis to estimate the prognostic capability of abnormal HRR. Results: Cutoff values were 13 beats for abnormal HRR1 and 22 beats for HRR2. In a multivariable model, predictors of abnormal HRR1 were diffusing capacity of the lung for carbon monoxide (odds ratio [OR], 0.4 per 10% predicted; 95% confidence interval [CI], 0.2 to 0.7; p = 0.003), change in heart rate from baseline to maximum (OR, 0.9; 95% CI, 0.8 to 0.97; p = 0.01), and having a right ventricular systolic pressure > 35 mm Hg as determined by transthoracic echocardiogram (OR, 12.7; 95% CI, 2.0 to 79.7; p = 0.01). Subjects with an abnormal HRR had significantly worse survival than subjects with a normal HRR (for HRR1, p = 0.0007 [log-rank test]; for HRR2, p = 0.03 [log-rank test]); these results held for the subgroup of 30 subjects without resting pulmonary hypertension (HRR1, p = 0.04 [log-rank test]). Among several candidate variables, abnormal HRR1 appeared to be the most potent predictor of mortality (hazard ratio, 5.2; 95% CI, 1.8 to 15.2; p = 0.004). Conclusion: Abnormal HRR after 6MWT predicts mortality in IPF patients. Research is needed to confirm these findings prospectively and to examine the mechanisms of HRR in IPF patients. PMID:19395579

  5. Data from the Mars Science Laboratory CheMin XRD/XRF Instrument

    Science.gov (United States)

    Vaniman, David; Blake, David; Bristow, Tom; DesMarais, David; Achilles, Cherie; Anderson, Robert; Crips, Joy; Morookian, John Michael; Spanovich, Nicole; Vasavada, Ashwin; hide

    2013-01-01

    The CheMin instrument on the Mars Science Laboratory (MSL) rover Curiosity uses a Co tube source and a CCD detector to acquire mineralogy from diffracted primary X-rays and chemical information from fluoresced X-rays. CheMin has been operating at the MSL Gale Crater field site since August 5, 2012 and has provided the first X-ray diffraction (XRD) analyses in situ on a body beyond Earth. Data from the first sample collected, the Rocknest eolian soil, identify a basaltic mineral suite, predominantly plagioclase (approx.An50), forsteritic olivine (approx.Fo58), augite and pigeonite, consistent with expectation that detrital grains on Mars would reflect widespread basaltic sources. Minor phases (each XRD. This amorphous component is attested to by a broad rise in background centered at approx.27deg 2(theta) (Co K(alpha)) and may include volcanic glass, impact glass, and poorly crystalline phases including iron oxyhydroxides; a rise at lower 2(theta) may indicate allophane or hisingerite. Constraints from phase chemistry of the crystalline components, compared with a Rocknest bulk composition from the APXS instrument on Curiosity, indicate that in sum the amorphous or poorly crystalline components are relatively Si, Al, Mg-poor and enriched in Ti, Cr, Fe, K, P, S, and Cl. All of the identified crystalline phases are volatile-free; H2O, SO2 and CO2 volatile releases from a split of this sample analyzed by the SAM instrument on Curiosity are associated with the amorphous or poorly ordered materials. The Rocknest eolian soil may be a mixture of local detritus, mostly crystalline, with a regional or global set of dominantly amorphous or poorly ordered components. The Rocknest sample was targeted by MSL for "first time analysis" to demonstrate that a loose deposit could be scooped, sieved to <150 microns, and delivered to instruments in the body of the rover. A drilled sample of sediment in outcrop is anticipated. At the time of writing this abstract, promising outcrops are

  6. The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc Min/+ mice.

    Science.gov (United States)

    Ono, Junya; Shime, Hiroaki; Takaki, Hiromi; Takashima, Ken; Funami, Kenji; Yoshida, Sumito; Takeda, Yohei; Matsumoto, Misako; Kasahara, Masanori; Seya, Tsukasa

    2017-10-17

    Intestinal tumorigenesis is promoted by myeloid differentiation primary response gene 88 (MyD88) activation in response to the components of microbiota in Apc Min/+ mice. Microbiota also contains double-stranded RNA (dsRNA), a ligand for TLR3, which activates the toll-like receptor adaptor molecule 1 (TICAM-1, also known as TRIF) pathway. We established Apc Min/+ Ticam1 -/- mice and their survival was compared to survival of Apc Min/+ Myd88 -/- and wild-type (WT) mice. The properties of polyps were investigated using immunofluorescence staining and RT-PCR analysis. We demonstrate that TICAM-1 is essential for suppression of polyp formation in Apc Min/+ mice. TICAM-1 knockout resulted in shorter survival of mice compared to WT mice or mice with knockout of MyD88 in the Apc Min/+ background. Polyps were more frequently formed in the distal intestine of Apc Min/+ Ticam1 -/- mice than in Apc Min/+ mice. Infiltration of immune cells such as CD11b + and CD8α + cells into the polyps was detected histologically. CD11b and CD8α mRNAs were increased in polyps of Apc Min/+ Ticam1 -/- mice compared to Apc Min/+ mice. Gene expression of inducible nitric oxide synthase (iNOS), interferon (IFN)-γ, CXCL9 and IL-12p40 was increased in polyps of Apc Min/+ Ticam1 -/- mice. mRNA and protein expression of c-Myc, a critical transcription factor for inflammation-associated polyposis, were increased in polyps of Apc Min/+ Ticam1 -/- mice. A Lactobacillus strain producing dsRNA was detected in feces of Apc Min/+ mice. These results imply that the TLR3/TICAM-1 pathway inhibits polyposis through suppression of c-Myc expression and supports long survival in Apc Min/+ mice.

  7. Determinants of poor 6-min walking distance in patients with COPD: the ECLIPSE cohort

    DEFF Research Database (Denmark)

    Spruit, Martijn A; Watkins, Michael L; Edwards, Lisa D

    2010-01-01

    BACKGROUND: The 6-min walking test (6MWT) is widely used to assess exercise tolerance in patients with chronic obstructive pulmonary disease (COPD). Given the prognostic significance of the 6MWT, it is important to identify why some COPD patients perform poorly in terms of this outcome. We aimed...... with COPD have significant differences in performance in the 6MWT even after stratification for GOLD stages. Moreover, severe airflow limitation by GOLD stage, degree of emphysema by CT, oxygen use during/after the 6MWT, presence of depressive symptoms and moderate to severe symptoms of dyspnea (mMRC grade...... >/=2) are significant clinical determinants of poor 6MWD performance (pulmonary and non-pulmonary factors) and psychological factors as evaluated from a large multinational cohort of well...

  8. The discovery of 13.72-min oscillations in the cool magnetic Ap star HD 217522

    International Nuclear Information System (INIS)

    Kurtz, D.W.

    1983-01-01

    The discovery is announced of oscillations with a period near 13.72 min in the cool magnetic Ap star HD 217522. 97 hr of high-speed photometric observations are presented, obtained on 18 nights spread over a time span of 74 days in 1982. The amplitude of the oscillations in HD 217522 is variable from night to night and also on a longer time-scale. A frequency analysis of the data identifies the principal frequency of oscillation to be 4.37435+-0.00014 hr -1 . Because of the complexities of the amplitude modulation of the light curve and the very low amplitude of the light variations, the data are insufficient for a complete frequency solution. This star is the seventh member of the class of rapidly oscillating Ap stars. (author)

  9. Quicksort, largest bucket, and min-wise hashing with limited independence

    DEFF Research Database (Denmark)

    Knudsen, Mathias Bæk Tejs; Stöckel, Morten

    2015-01-01

    Randomized algorithms and data structures are often analyzed under the assumption of access to a perfect source of randomness. The most fundamental metric used to measure how “random” a hash function or a random number generator is, is its independence: a sequence of random variables is said...... to be k-independent if every variable is uniform and every size k subset is independent. In this paper we consider three classic algorithms under limited independence. Besides the theoretical interest in removing the unrealistic assumption of full independence, the work is motivated by lower independence...... being more practical. We provide new bounds for randomized quicksort, min-wise hashing and largest bucket size under limited independence. Our results can be summarized as follows. Randomized Quicksort. When pivot elements are computed using a 5-independent hash function, Karloff and Raghavan, J.ACM’93...

  10. FUNPACK-2, Subroutine Library, Bessel Function, Elliptical Integrals, Min-max Approximation

    International Nuclear Information System (INIS)

    Cody, W.J.; Garbow, Burton S.

    1975-01-01

    1 - Description of problem or function: FUNPACK is a collection of FORTRAN subroutines to evaluate certain special functions. The individual subroutines are (Identification/Description): NATSI0 F2I0 Bessel function I 0 ; NATSI1 F2I1 Bessel function I 1 ; NATSJ0 F2J0 Bessel function J 0 ; NATSJ1 F2J1 Bessel function J 1 ; NATSK0 F2K0 Bessel function K 0 ; NATSK1 F2K1 Bessel function K 1 ; NATSBESY F2BY Bessel function Y ν ; DAW F1DW Dawson's integral; DELIPK F1EK Complete elliptic integral of the first kind; DELIPE F1EE Complete elliptic integral of the second kind; DEI F1EI Exponential integrals; NATSPSI F2PS Psi (logarithmic derivative of gamma function); MONERR F1MO Error monitoring package . 2 - Method of solution: FUNPACK uses evaluation of min-max approximations

  11. Fuzzy Mutual Information Based min-Redundancy and Max-Relevance Heterogeneous Feature Selection

    Directory of Open Access Journals (Sweden)

    Daren Yu

    2011-08-01

    Full Text Available Feature selection is an important preprocessing step in pattern classification and machine learning, and mutual information is widely used to measure relevance between features and decision. However, it is difficult to directly calculate relevance between continuous or fuzzy features using mutual information. In this paper we introduce the fuzzy information entropy and fuzzy mutual information for computing relevance between numerical or fuzzy features and decision. The relationship between fuzzy information entropy and differential entropy is also discussed. Moreover, we combine fuzzy mutual information with qmin-Redundancy-Max-Relevanceq, qMax-Dependencyq and min-Redundancy-Max-Dependencyq algorithms. The performance and stability of the proposed algorithms are tested on benchmark data sets. Experimental results show the proposed algorithms are effective and stable.

  12. Does the quality of chest compressions deteriorate when the chest compression rate is above 120/min?

    Science.gov (United States)

    Lee, Soo Hoon; Kim, Kyuseok; Lee, Jae Hyuk; Kim, Taeyun; Kang, Changwoo; Park, Chanjong; Kim, Joonghee; Jo, You Hwan; Rhee, Joong Eui; Kim, Dong Hoon

    2014-08-01

    The quality of chest compressions along with defibrillation is the cornerstone of cardiopulmonary resuscitation (CPR), which is known to improve the outcome of cardiac arrest. We aimed to investigate the relationship between the compression rate and other CPR quality parameters including compression depth and recoil. A conventional CPR training for lay rescuers was performed 2 weeks before the 'CPR contest'. CPR anytime training kits were distributed to respective participants for self-training on their own in their own time. The participants were tested for two-person CPR in pairs. The quantitative and qualitative data regarding the quality of CPR were collected from a standardised check list and SkillReporter, and compared by the compression rate. A total of 161 teams consisting of 322 students, which includes 116 men and 206 women, participated in the CPR contest. The mean depth and rate for chest compression were 49.0±8.2 mm and 110.2±10.2/min. Significantly deeper chest compression depths were noted at rates over 120/min than those at any other rates (47.0±7.4, 48.8±8.4, 52.3±6.7, p=0.008). Chest compression depth was proportional to chest compression rate (r=0.206, pcompression including chest compression depth and chest recoil by chest compression rate. Further evaluation regarding the upper limit of the chest compression rate is needed to ensure complete full chest wall recoil while maintaining an adequate chest compression depth. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  13. Chemopreventive Effects of RXR-Selective Rexinoid Bexarotene on Intestinal Neoplasia of ApcMin/+ Mice

    Directory of Open Access Journals (Sweden)

    Naveena B. Janakiram

    2012-02-01

    Full Text Available Retinoid X receptor (RXR has been implicated in several neoplastic diseases. Previously, we have shown that RXR-α is downregulated in human and rodent colonic tumors, suggesting a potential target for colon cancer prevention (http://www.cancer.org/Cancer/ColonandRectumCancer/DetailedGuide/colorectal-cancer-key-statistics. Experiments were designed to assess the chemopreventive efficacy of the selective RXR agonist bexarotene for the suppression of intestinal tumorigenesis in ApcMin/+ mice. Before the efficacy studies, we determined that the maximal tolerated dose in C57BL/6J mice was less than 400 ppm. For the efficacy study, 6-week-old male and female C57BL/6J-ApcMin/+ mice (nine mice per group were fed diets containing 0, 30, and 60 ppm of bexarotene or 200 ppm of bexarotene for 80 days before intestinal tumors were evaluated. Dietary administration of 30 and 60 ppm of bexarotene suppressed the intestinal polyp formation by 38% (P < .015 and 60% (P < .0001 in males, respectively, and by 8.5% and 37% (P < .007 in females, respectively. Also, significant inhibition (50%–100% of colonic tumor formation was observed in both male and female mice with bexarotene treatment. Administration of 200 ppm of bexarotene showed significant suppression of tumor formation (66%, P < .0001; however, it had significant toxicity. Intestinal tumors of bexarotene-fed mice showed significantly reduced expression of proliferating cell nuclear antigen (60%, P < .0001, cyclin D1, and cyclooxygenase 2 and increased RXR-α messenger RNA and uptake of oleate (34%, P < .01. Also, bexarotene-fed mice showed dose-dependent suppression of serum triglycerides (25%–72%, P < .0001 and inflammatory cytokines.

  14. METAPHORIZATION AND METONYMIZATIO: DIACHRONIC DEVELOPMENT OF VERBS OF VOLITION IN SOUTHERN MIN

    Directory of Open Access Journals (Sweden)

    Miao-Hsia Chang

    2009-06-01

    Full Text Available This paper investigates the diachrony of the verbs of volition ai and beh in Southern Min (SM. The data include historical SM texts (16th-19th century, folk songs in the late 19th to early 20th century, and contemporary natural Taiwanese Southern Min conversations. The results mainly mark two stages of the development of ai and beh: historical (before 1900 and contemporary SM. Since the 16th century (Ming Dynasty, ai has been used as a verb of volition indicating love, intention or hope. As for historical ai, it marked future, specialized however for predicting an adverse future. In contemporary SM, a sense of necessity emerged with the use of ai denoting general agreement among people. Seven senses are attributed to historical beh: want/intention/hope, future, excessiveness, necessity, proximity and conditionality. In contemporary SM, the indication of the want of an entity has become a less preferred use, and necessity is only preserved when indicating puzzlement and helplessness. The diachronic developments of ai and beh demonstrate an interplay of metaphorization and metonymization (Traugott and Dasher 2002:27. Metaphorization contributes first to the semantic shift of ai and beh from “to want; to love” to “to intend to” and a concurrent categorical change from lexical verb into auxiliary, and second, to the evolution of future. Metonymization activates an even wider range of uses and meaning change, including the pragmatic strengthening of interpretations such as excessiveness (beh, necessity (ai, beh, proximity (beh and conditional (beh, and prediction of an undesirable future (ai.

  15. The N-terminal amphipathic helix of the topological specificity factor MinE is associated with shaping membrane curvature.

    Directory of Open Access Journals (Sweden)

    Yu-Ling Shih

    Full Text Available Pole-to-pole oscillations of the Min proteins in Escherichia coli are required for the proper placement of the division septum. Direct interaction of MinE with the cell membrane is critical for the dynamic behavior of the Min system. In vitro, this MinE-membrane interaction led to membrane deformation; however, the underlying mechanism remained unclear. Here we report that MinE-induced membrane deformation involves the formation of an amphipathic helix of MinE(2-9, which, together with the adjacent basic residues, function as membrane anchors. Biochemical evidence suggested that the membrane association induces formation of the helix, with the helical face, consisting of A2, L3, and F6, inserted into the membrane. Insertion of this helix into the cell membrane can influence local membrane curvature and lead to drastic changes in membrane topology. Accordingly, MinE showed characteristic features of protein-induced membrane tubulation and lipid clustering in in vitro reconstituted systems. In conclusion, MinE shares common protein signatures with a group of membrane trafficking proteins in eukaryotic cells. These MinE signatures appear to affect membrane curvature.

  16. The sensorimotor and cognitive deficits in rats following 90- and 120-min transient occlusion of the middle cerebral artery.

    Science.gov (United States)

    Zvejniece, Liga; Svalbe, Baiba; Liepinsh, Edgars; Pulks, Eduards; Dambrova, Maija

    2012-07-15

    Middle cerebral artery occlusion (MCAO) is the most commonly used method to study the neurological and histological outcomes and the pathological mechanisms of ischaemic stroke. The current work compares sensorimotor and cognitive deficits and the infarct volume in rats following a transient 90- or 120-min MCAO, which allows the appropriate behavioural tests to be chosen based on the goal and design of the experiment. In the beam-walking test, we found significant differences between the 90- and 120-min MCAO groups in the number of foot faults made with the impaired hindlimb on post-stroke days 3, 7 and 14. In the cylinder test, a difference between the 90- and 120-min groups was observed on post-operation day 14. The responses to tactile and proprioceptive stimulation were impaired to a similar extent after 90- and 120-min MCAO in the vibrissae-evoked forelimb-placing and limb-placing tests. Moreover, we found significant memory impairment in the 120-min MCAO group 6 days after the acquisition trial. The brain tissue damage was significantly higher after 120-min occlusion of the MCA compared with 90-min occlusion; the infarct volumes were 13% and 25% of the contralateral hemispheres, respectively. In conclusion, both the 90- and 120-min occlusion models result in a significant impairment of sensorimotor, tactile and proprioceptive function, but memory impairment is only observed in the 120-min MCAO group. The beam-walking and cylinder tests detected neurological dysfunction after the 120-min MCAO, whereas the limb-placing and vibrissae-evoked forelimb-placing tests were able to evaluate the neurological dysfunction in rats after 90- and 120-min MCAO. Copyright © 2012 Elsevier B.V. All rights reserved.

  17. IMPLEMENTASI SUPERVISI PENDIDIKAN DALAM MENINGKATKAN PROSES PEMBELAJARAN DI MIN SUKADAMAI KOTA BANDA ACEH

    Directory of Open Access Journals (Sweden)

    Cut Suryani

    2015-08-01

    Full Text Available A principal as a supervisor has to conduct supervision in his/her school. Hence he/she must be able to perform a variety of monitoring and control to improve the performance of teachers. Supervision and control are preventive ways to prevent teachers to do irregularities and thus will be more careful in carrying out his work as educators. This research is intended to study supervision activities performed by principal of Islamic Elementary School (Madrasah Ibtidaiyah Negeri (MIN Sukadamai Banda Aceh. The results of this research show several findings: 1. The focus of supervision activities performed by principal can be identified in two things i.e supervision activities concerning the teachers’ administration and teachers’ teaching practices; 2. Supervision activity is useful for teachers to solve educational problems at the time of learning, and to provide motivation for them to improve the knowledge to become professionals in teaching and learning process; 3. Principal’s barriers in supervision consists of overlapping activities and lack of operational budget.

  18. Max-min SINR low complexity transceiver design for single cell massive MIMO

    KAUST Repository

    Sifaou, Houssem

    2016-08-11

    This work focuses on large scale multi-user MIMO systems in which the base station (BS) outfitted with M antennas communicates with K single antenna user equipments (UEs). In particular, we aim at designing the linear precoder and receiver that maximizes the minimum signal-to-interference-plus-noise ratio (SINR) subject to a given power constraint. To gain insights into the structure of the optimal precoder and receiver as well as to reduce the computational complexity for their implementation, we analyze the asymptotic regime where M and K grow large with a given ratio and make use of random matrix theory (RMT) tools to compute accurate approximations. Although simpler, the implementation of the asymptotic precoder and receiver requires fast inversions of large matrices in every coherence period. To overcome this issue, we apply the truncated polynomial expansion (TPE) technique to the precoding and receiving vector of each UE and make use of RMT to determine the optimal weighting coefficients that asymptotically solve the max-min SINR problem. Numerical results are used to show that the proposed TPE-based precoder and receiver almost achieve the same performance as the optimal ones while requiring a lower complexity.

  19. Treeline dynamics in response to climate change in the Min Mountains, southwestern China.

    Science.gov (United States)

    Zhao, Zhi-Jiang; Shen, Guo-Zhen; Tan, Liu-Yi; Kang, Dong-Wei; Wang, Meng-Jun; Kang, Wen; Guo, Wen-Xia; Zeppel, Melanie Jb; Yu, Qiang; Li, Jun-Qing

    2013-12-01

    Abies faxoniana is the dominant plant species of the forest ecosystem on the eastern edge of Qinghai-Tibet Plateau, where the treeline is strongly defined by climate. The tree-ring chronologies and age structure of Abies faxoniana were developed in the treeline ecotones on the northwestern and southeastern aspects of the Min Mountains in the Wanglang Nature Reserve to examine the treeline dynamics of recent decades in response to climate change. On the northwestern aspect, correlation analysis showed that the radial growth was significantly and positively correlated with precipitation in current January and monthly mean temperature in current April, but significantly and negatively correlated with monthly mean temperature in previous August. On the southeastern aspect, the radial growth was significantly negatively correlated with monthly mean temperature in previous July and August. The different responses of radial growth to climatic variability on both the aspects might be mainly due to the micro-environmental conditions. The recruitment benefited from the warm temperature in current April, July and September on the northwestern aspect. The responses of radial growth and recruitment to climatic variability were similar on the northwestern slope. Recruitment was greatly restricted by competition with dense bamboos on the southeastern aspect.

  20. Max-Min Optimality of Service Rate Control in Closed Queueing Networks

    KAUST Repository

    Xia, Li

    2013-04-01

    In this technical note, we discuss the optimality properties of service rate control in closed Jackson networks. We prove that when the cost function is linear to a particular service rate, the system performance is monotonic w.r.t. (with respect to) that service rate and the optimal value of that service rate can be either maximum or minimum (we call it Max-Min optimality); When the second-order derivative of the cost function w.r.t. a particular service rate is always positive (negative), which makes the cost function strictly convex (concave), the optimal value of such service rate for the performance maximization (minimization) problem can be either maximum or minimum. To the best of our knowledge, this is the most general result for the optimality of service rates in closed Jackson networks and all the previous works only involve the first conclusion. Moreover, our result is also valid for both the state-dependent and load-dependent service rates, under both the time-average and customer-average performance criteria.

  1. [Preservative-free glaucoma treatment : Selection of the correct treatment in 1 min].

    Science.gov (United States)

    Pfennigsdorf, S; Eschstruth, P

    2016-05-01

    The presence of preservatives in topical glaucoma treatments may impact ocular surface function and structure. For treatment to be effective, side effects need to be minimized, in order to promote compliance and allow continuation of therapy. Therefore, in daily clinical practice, it needs to be decided on an individual basis whether a preservative-free treatment is required. This study aimed to develop a questionnaire which helps to quickly and easily identify patients who require preservative-free treatment. A questionnaire was prepared to collect relevant clinical findings needed to make a therapeutic decision (preservative-free required? Yes/No). Moreover, a rating scheme was developed to enable efficient final assessment of the collected data. To check their practicability in daily clinical practice, both instruments were tested in 11 ophthalmological centers in Germany. The questionnaire and rating scheme were easy to use, integrated efficiently into everyday routine, and performed in about 1 min. Data of 1150 glaucoma patients were collected and preservative-free eyedrops recommended for 586 (51 %). Parameters most frequently associated with such a recommendation were a reduced tear film break-up time of preservative-free glaucoma threatment should be recommended. Individualized therapy decisions can thus be made, allowing goal-oriented use of preservative-free antiglaucomatosa. This might help to promote compliance and lead to reduced progression of glaucoma.

  2. Secrecy Outage of Max-Min TAS Scheme in MIMO-NOMA Systems

    KAUST Repository

    Lei, Hongjiang

    2018-04-09

    This paper considers a secure non-orthogonal multiple access system, where confidential messages are transmitted from a base station to multiple legitimate destinations and wiretapped by multiple illegitimate receivers. It is assumed that all the channels experience Nakagami-m fading model and all the nodes are equipped with multiple antennas, respectively. Both non-colluding and colluding eavesdroppers are respectively considered. Max-min (MM) transmit antenna selection (TAS) strategy is adopted to improve the secrecy performance of the target system, in which both users in user paring are considered simultaneously. In particular, closed-form expressions for the cumulative distribution function of the signal-to-interference-noise ratio at the legitimate user are derived firstly. Then we obtain the exact and asymptotic analytical results in a closed form for the secrecy outage probability of MM TAS scheme. Monte-Carlo simulation results are presented to corroborate the correctness of the analysis. The results show that the secrecy diversity order is zero and non-zero for fixed and dynamic power allocations, respectively.

  3. Monitoring the informational efficiency of European corporate bond markets with dynamical permutation min-entropy

    Science.gov (United States)

    Zunino, Luciano; Bariviera, Aurelio F.; Guercio, M. Belén; Martinez, Lisana B.; Rosso, Osvaldo A.

    2016-08-01

    In this paper the permutation min-entropy has been implemented to unveil the presence of temporal structures in the daily values of European corporate bond indices from April 2001 to August 2015. More precisely, the informational efficiency evolution of the prices of fifteen sectorial indices has been carefully studied by estimating this information-theory-derived symbolic tool over a sliding time window. Such a dynamical analysis makes possible to obtain relevant conclusions about the effect that the 2008 credit crisis has had on the different European corporate bond sectors. It is found that the informational efficiency of some sectors, namely banks, financial services, insurance, and basic resources, has been strongly reduced due to the financial crisis whereas another set of sectors, integrated by chemicals, automobiles, media, energy, construction, industrial goods & services, technology, and telecommunications has only suffered a transitory loss of efficiency. Last but not least, the food & beverage, healthcare, and utilities sectors show a behavior close to a random walk practically along all the period of analysis, confirming a remarkable immunity against the 2008 financial crisis.

  4. Minimum Cycle Basis and All-Pairs Min Cut of a Planar Graph in Subquadratic Time

    DEFF Research Database (Denmark)

    Wulff-Nilsen, Christian

    2009-01-01

    equivalent to the minimum cycle basis problem for planar graphs. We also obtain O(n3/2 log n) time and O(n3/2) space algorithms for finding, respectively, the weight vector and a Gomory-Hu tree of G. The previous best time and space bound for these two problems was quadratic. From our Gomory-Hu tree...... show that this is optimal if an explicit represen- tation of the basis is required. We then present an O(n3/2 log n) time and O(n3/2) space algorithm that computes a minimum cycle basis implicitly. From this result, we obtain an output-sensitive algorithm that explicitly computes a minimum cycle basis...... in O(n3/2 log n + C) time and O(n3/2 + C) space, where C is the total size (number of edges and vertices) of the cycles in the basis. These bounds reduce to O(n3/2 log n) and O(n3/2), respectively, when G is unweighted. We get similar results for the all-pairs min cut problem since it is dual...

  5. Secrecy Outage of Max-Min TAS Scheme in MIMO-NOMA Systems

    KAUST Repository

    Lei, Hongjiang; Zhang, Jianming; Park, Kihong; Xu, Peng; Zhang, Zufan; Pan, Gaofeng; Alouini, Mohamed-Slim

    2018-01-01

    This paper considers a secure non-orthogonal multiple access system, where confidential messages are transmitted from a base station to multiple legitimate destinations and wiretapped by multiple illegitimate receivers. It is assumed that all the channels experience Nakagami-m fading model and all the nodes are equipped with multiple antennas, respectively. Both non-colluding and colluding eavesdroppers are respectively considered. Max-min (MM) transmit antenna selection (TAS) strategy is adopted to improve the secrecy performance of the target system, in which both users in user paring are considered simultaneously. In particular, closed-form expressions for the cumulative distribution function of the signal-to-interference-noise ratio at the legitimate user are derived firstly. Then we obtain the exact and asymptotic analytical results in a closed form for the secrecy outage probability of MM TAS scheme. Monte-Carlo simulation results are presented to corroborate the correctness of the analysis. The results show that the secrecy diversity order is zero and non-zero for fixed and dynamic power allocations, respectively.

  6. Vidas célebres, vidas minúsculas: Vasari, Foucault, Michon

    Directory of Open Access Journals (Sweden)

    Kelvin Falcão

    2014-12-01

    Full Text Available O primeiro movimento deste ensaio consiste no esboço de um percurso breve a partir da obra de Michel Foucault, rastreando o uso do significante “vidas” em alguns textos do autor francês. Dois eixos são delineados a partir daí: o primeiro deles diz respeito à leitura foucaultiana das “vidas célebres” de Giorgio Vasari; o segundo diz respeito às “vidas infames”, que Foucault rastreia nos arquivos policiais franceses. Em seguida, inicia-se um desvio em direção à literatura do século XX, considerando o envolvimento da ficção com a emergência da discursividade biográfica, sua ressonância política e o emprego crítico, mais uma vez, do significante “vidas”. Com esse contexto de fundo estabelecido, o ensaio conclui-se com uma análise de Vidas minúsculas, do escritor francês Pierre Michon. The first movement of this essay is to outline a brief path from the work of Michel Foucault, tracking the use of the signifier “lives” in some texts of the French author. Two axes are delineated from there, the first one concerns Foucault’s reading of “renowed lives” by Giorgio Vasari; the second concerns the “infamous lives”, which Foucault traces from the French police files. Then begins a shift toward twentiethcentury literature, considering the involvement of fiction with the emergence of biographical discourse, its political resonance and, again, the critical use of the signifier “lives”. With this background context established, the essay concludes with a analysis of Small Lives, by French writer Pierre Michon.

  7. The 6-min push test is reliable and predicts low fitness in spinal cord injury.

    Science.gov (United States)

    Cowan, Rachel E; Callahan, Morgan K; Nash, Mark S

    2012-10-01

    The objective of this study is to assess 6-min push test (6MPT) reliability, determine whether the 6MPT is sensitive to fitness differences, and assess if 6MPT distance predicts fitness level in persons with spinal cord injury (SCI) or disease. Forty individuals with SCI who could self-propel a manual wheelchair completed an incremental arm crank peak oxygen consumption assessment and two 6MPTs across 3 d (37% tetraplegia (TP), 63% paraplegia (PP), 85% men, 70% white, 63% Hispanic, mean age = 34 ± 10 yr, mean duration of injury = 13 ± 10 yr, and mean body mass index = 24 ± 5 kg.m). Intraclass correlation and Bland-Altman plots assessed 6MPT distance (m) reliability. Mann-Whitney U test compared 6MPT distance (m) of high and low fitness groups for TP and PP. The fitness status prediction was developed using N = 30 and validated in N = 10 (validation group (VG)). A nonstatistical prediction approach, below or above a threshold distance (TP = 445 m and PP = 604 m), was validated statistically by binomial logistic regression. Accuracy, sensitivity, and specificity were computed to evaluate the threshold approach. Intraclass correlation coefficients exceeded 0.90 for the whole sample and the TP/PP subsets. High fitness persons propelled farther than low fitness persons for both TP/PP (both P < 0.05). Binomial logistic regression (P < 0.008) predicted the same fitness levels in the VG as the threshold approach. In the VG, overall accuracy was 70%. Eighty-six percent of low fitness persons were correctly identified (sensitivity), and 33% of high fitness persons were correctly identified (specificity). The 6MPT may be a useful tool for SCI clinicians and researchers. 6MPT distance demonstrates excellent reliability and is sensitive to differences in fitness level. 6MPT distances less than a threshold distance may be an effective approach to identify low fitness in person with SCI.

  8. Max–min Bin Packing Algorithm and its application in nano-particles filling

    International Nuclear Information System (INIS)

    Zhu, Dingju

    2016-01-01

    With regard to existing bin packing algorithms, higher packing efficiency often leads to lower packing speed while higher packing speed leads to lower packing efficiency. Packing speed and packing efficiency of existing bin packing algorithms including NFD, NF, FF, FFD, BF and BFD correlates negatively with each other, thus resulting in the failure of existing bin packing algorithms to satisfy the demand of nano-particles filling for both high speed and high efficiency. The paper provides a new bin packing algorithm, Max–min Bin Packing Algorithm (MM), which realizes both high packing speed and high packing efficiency. MM has the same packing speed as NFD (whose packing speed ranks no. 1 among existing bin packing algorithms); in case that the size repetition rate of objects to be packed is over 5, MM can realize almost the same packing efficiency as BFD (whose packing efficiency ranks No. 1 among existing bin packing algorithms), and in case that the size repetition rate of objects to be packed is over 500, MM can achieve exactly the same packing efficiency as BFD. With respect to application of nano-particles filling, the size repetition rate of nano particles to be packed is usually in thousands or ten thousands, far higher than 5 or 500. Consequently, in application of nano-particles filling, the packing efficiency of MM is exactly equal to that of BFD. Thus the irreconcilable conflict between packing speed and packing efficiency is successfully removed by MM, which leads to MM having better packing effect than any existing bin packing algorithm. In practice, there are few cases when the size repetition of objects to be packed is lower than 5. Therefore the MM is not necessarily limited to nano-particles filling, and can also be widely used in other applications besides nano-particles filling. Especially, MM has significant value in application of nano-particles filling such as nano printing and nano tooth filling.

  9. A Study on Liver Scan using 113mIn Colloid

    International Nuclear Information System (INIS)

    Koh, Chang Soon; Rhee, Chong Hoen; Chang, Kochang; Hong, Chang Gi

    1969-01-01

    There have been reported numberous cases of liver scanning in use of 198 Au colloid by many investigators, however, one in use of 113m In colloid has not been reported as yet in this country. The dose of 113 mIn for high diagnostic value in examination of each organ was determined and the diagnostic interpretability of liver scanning with the use of 113m In was carefully evaluated in comparison with the results of the liver scanning by the conventionally applied radioisotope. The comparative study of both figures of liver scanning with the use of 113m In colloid and 198 Au colloid delivered following results:1) The liver uptake rate and clearance into peripheral blood were accentuated more in case of 113m In colloid than in case of 198 Au colloid. 2) The interpretability of space occupying lesion in liver scanning with 113m In was also superior to one with 198 Au. 3) The figure of liver scanning with 113m In colloid corresponds not always to the figure with 198 Au. This difference can be explained by difference of phagocytic ability of reticuloendothelial system within liver. 4) In the liver scanning with 113m In colloid, the spleen is also visualized even in normal examine. 5) In the cases of disturbed liver function, uptake is more decreased in use of 113m In colloid than in 198 Au, in the spleen, however, the way is contrary. 6) With use of 113m In colloid, the time required for scanning could be shortened in comparison with 198 Au. 7) The filtration of 113m In colloid for scanning prior to human administration gives an expectation for better scanning figure.

  10. Cell enlargement of plant tissue explants oscillates with a temperature-compensated period of ca. 24 min

    Science.gov (United States)

    Morre, D. James; Ternes, Philipp; Morre, Dorothy M.

    2002-01-01

    Rate of plant cell enlargement, measured at intervals of 3 min using a sensitive linear transducer, oscillates with a minimum period of about 24 min that parallels the 24-min periodicity observed with the oxidation of NADH by the external plasma membrane NADH oxidase and of single cells measured previously by video-enhanced light microscopy. Also exhibiting 24-min oscillations is the steady-state rate of cell enlargement induced by the addition of the auxin herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) or the natural auxin indole-3-acetic acid (IAA). Immediately following 2,4-D addition, a very complex pattern of oscillations is frequently observed. However, after several hours a dominant 24-min period emerges. The length of the 24-min period is temperature compensated and remains constant at 24 min when measured at 15, 25 or 35 degrees C, despite the fact that the rate of cell enlargement approximately doubles for each 10 degree C rise over this same range of temperatures.

  11. Benchmarking of the Oxford Nanopore MinION sequencing for quantitative and qualitative assessment of cDNA populations.

    Science.gov (United States)

    Oikonomopoulos, Spyros; Wang, Yu Chang; Djambazian, Haig; Badescu, Dunarel; Ragoussis, Jiannis

    2016-08-24

    To assess the performance of the Oxford Nanopore Technologies MinION sequencing platform, cDNAs from the External RNA Controls Consortium (ERCC) RNA Spike-In mix were sequenced. This mix mimics mammalian mRNA species and consists of 92 polyadenylated transcripts with known concentration. cDNA libraries were generated using a template switching protocol to facilitate the direct comparison between different sequencing platforms. The MinION performance was assessed for its ability to sequence the cDNAs directly with good accuracy in terms of abundance and full length. The abundance of the ERCC cDNA molecules sequenced by MinION agreed with their expected concentration. No length or GC content bias was observed. The majority of cDNAs were sequenced as full length. Additionally, a complex cDNA population derived from a human HEK-293 cell line was sequenced on an Illumina HiSeq 2500, PacBio RS II and ONT MinION platforms. We observed that there was a good agreement in the measured cDNA abundance between PacBio RS II and ONT MinION (rpearson = 0.82, isoforms with length more than 700bp) and between Illumina HiSeq 2500 and ONT MinION (rpearson = 0.75). This indicates that the ONT MinION can sequence quantitatively both long and short full length cDNA molecules.

  12. MODIS/Aqua Clear Radiance Statistics Indexed to Global Grid 5-Min L2 Swath 10km V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The MODIS/Aqua Clear Radiance Statistics Indexed to Global Grid 5-Min L2 Swath 10km (MYDCSR_G) provides a variety of statistical measures that characterize observed...

  13. Promotion of minTBP-1-PRGDN on the attachment, proliferation and collagen I synthesis of human keratocyte on titanium

    Directory of Open Access Journals (Sweden)

    Xin-Yu Li

    2014-02-01

    Full Text Available AIM:To investigate the influence of minTBP-1-PRGDN on the attachment, proliferation and collagen I synthesis of human keratocyte on titanium (Ti surface.METHODS:The chimeric peptide RKLPDAPRGDN (minTBP-1-PRGDN was synthesized by connecting RKLPDA (minTBP-1 to the N-terminal of PRGDN , the influence of minTBP-1-PRGDN on the attachment, proliferation and collagen I synthesis of human keratocyte on Ti surface were tested using PRGDN and minTBP-1as controls. The keratocytes attached to the surface of Ti were either stained with FITC-labeled phalloidin and viewed with fluorescence microscope or quantified with alamar Blue method. The proliferation of keratocytes on Ti were quantified with 3-(4,5-dim- ethylthiazol-2-yl-2, 5-diphenyltetrazolium bromide up-taking methods. The secretion of type I collagen were determined using an ELISA kit.RESULTS:The results showed that minTBP-1-PRGDN at a concentration of 100ng/mL was the most potent peptide to enhance the attachment of human keratocytes to the surface of Ti (1.40±0.03 folds, P=0.003, to promote the proliferation (1.26±0.05 folds, P=0.014 and the synthesis of type I collagen (1.530±0.128, P=0.008. MinTBP-1 at the same concentration could only promote the attachment (1.13±0.04 folds, P=0.020 and proliferation(1.15±0.06 folds, P=0.021, while PRGDN had no significant influence (P>0.05.CONCLUSION:Our data shows that the novel chimeric peptide minTBP-1-PRGDN could promote the attachment, proliferation and type I collagen synthesis of human keratocytes on the surface of Ti.

  14. Cellular architecture mediates DivIVA ultrastructure and regulates min activity in Bacillus subtilis | Center for Cancer Research

    Science.gov (United States)

    The Min system in rod-shaped bacteria restricts improper assembly of the division septum. In Escherichia coli, the Min system localizes to the cell poles, but in Bacillus subtilis, it is recruited to nascent cell division sites at mid-cell to prevent aberrant septation events immediately adjacent to a constricting septum. How does the cell spatially and temporally restrict the

  15. Mammary tumorigenesis in APC{sup min/+} mice is enhanced by X-irradiation with a characteristic age dependence

    Energy Technology Data Exchange (ETDEWEB)

    Tatsuhiko, Imaoka; Mayumi, Nishimura; Shizuko, Kakinuma; Yoshiya, Shimada [National Institute of Radiological Sciences, Experimental Radiobiology for Children' s Health Research Group, Research, Center for Radiation Protection (Japan); Mieko, Okamoto [Tokyo Metropolitan Institute of Medical Science (Japan)

    2006-07-01

    The ApcM{sup min/+} (Min) mouse is a genetically predisposed model of both intestinal and mammary tumorigenesis. We investigated age-related changes in the susceptibility of mice (before, during and after puberty) to radiation-induced mammary tumorigenesis using this model. Female Min and wild-type mice having the C57BL/6J background were irradiated with 2 Gy of X-rays at 2, 5, 7 and 10 weeks and sacrificed at 18 weeks of age. Min mice irradiated at 7 to 10 weeks of age (after puberty) developed mammary tumors with squamous metaplasia, whereas their wild-type litter-mates did not. Interestingly, irradiation of Min mice at 2 to 5 weeks (before and during puberty, respectively) did not induce mammary tumors but rather cystic nodules with metaplasia. The mammary tumors exhibited increased nuclear beta-catenin protein and loss of the wild-type Apc allele. Our results show that susceptibility to radiation-induced mammary tumorigenesis increases after puberty in Min mice, suggesting that the tumorigenic effect of ionizing radiation targets the lobular-alveolar progenitor cells, which increase in number with age and are controlled by beta-catenin signaling. (author)

  16. Validation of functional fetal autonomic brain age score fABAS in 5 min short recordings

    International Nuclear Information System (INIS)

    Hoyer, Dirk; Kowalski, Eva-Maria; Schmidt, Alexander; Witte, Otto W; Schneider, Uwe; Schleußner, Ekkehard; Hatzmann, Wolfgang; Grönemeyer, Dietrich HW; Van Leeuwen, Peter

    2015-01-01

    With the objective of evaluating the functional maturation age and developmental disturbances we have previously introduced the fetal autonomic brain age score (fABAS) using 30 min fetal magnetocardiographic recordings (fMCG, Jena). The score is based on heart rate pattern indices that are related to universal principles of developmental biology. The present work aims at the validation of the fABAS methodology on 5 min recordings from an independent database (fMCG, Bochum).We found high agreement of fABAS obtained from Jena normal fetuses (5 min subsets, n  =  364) and Bochum recordings (n  =  322, normal fetuses). fABAS of 48 recordings from fetuses with intra-uterine growth restriction (IUGR, Bochum) was reduced in most of the cases, a result consistent with IUGR fetuses from Jena previously reported. fABAS calculated from 5 min snapshots only partly covers the accuracy when compared to fABAS from 30 min recordings. More precise diagnosis requires longer recordings.fABAS obtained from fMCG recordings is a strong candidate for standardized assessment of functional maturation age and developmental disturbances. Even 5 min recordings seem to be valuable for screening for maturation problems. (paper)

  17. A novel approach to assess the spontaneous gastrointestinal bleeding risk of antithrombotic agents using Apc(min/+) mice.

    Science.gov (United States)

    Wei, Huijun; Shang, Jin; Keohane, CarolAnn; Wang, Min; Li, Qiu; Ni, Weihua; O'Neill, Kim; Chintala, Madhu

    2014-06-01

    Assessment of the bleeding risk of antithrombotic agents is usually performed in healthy animals with some form of vascular injury to peripheral organs to induce bleeding. However, bleeding observed in patients with currently marketed antithrombotic drugs is typically spontaneous in nature such as intracranial haemorrhage (ICH) and gastrointestinal (GI) bleeding, which happens most frequently on top of preexisting pathologies such as GI ulcerations and polyps. Apc(min/+) mice are reported to develop multiple adenomas through the entire intestinal tract and display progressive anaemia.In this study, we evaluated the potential utility of Apc(min/+) mice as a model for assessing spontaneous GI bleeding with antithrombotic agents. Apc(min/+) mice exhibited progressive blood loss starting at the age of nine weeks. Despite the increase in bleeding, Apc(min/+) mice were in a hypercoagulable state and displayed an age-dependent increase in thrombin generation and circulating fibrinogen as well as a significant decrease in clotting times. We evaluated the effect of warfarin, dabigatran etexilate, apixaban and clopidogrel in this model by administering them in diet or in the drinking water to mice for 1-4 weeks. All of these marketed drugs significantly increased GI bleeding in Apc(min/+) mice, but not in wild-type mice. Although different exposure profiles of these antithrombotic agents make it challenging to compare the bleeding risk of compounds, our results indicate that the Apc(min/+) mouse may be a sensitive preclinical model for assessing the spontaneous GI bleeding risk of novel antithrombotic agents.

  18. Using the MDCT thick slab MinIP method for the follow-up of pulmonary emphysema.

    Science.gov (United States)

    Lan, Hai; Nishitani, Hiromu; Nishihara, Sadamitsu; Ueno, Junji; Takao, Shoichiro; Iwamoto, Seiji; Kawanaka, Takashi; Mahmut, Mawlan; Qingge, Si

    2011-08-01

    The purpose of this study was to evaluate the usefulness of thick slab minimum intensity projection (MinIP) as a follow-up method in patients with pulmonary emphysema. This method was used to determine the presence or absence of changes over time in the lung field based on multi-detector-row CT (MDCT) data. Among patients diagnosed with pulmonary emphysema who underwent 16-MDCT (slice thickness, 1 mm) twice at an interval of 6 months or more, 12 patients without changes in the lung field and 14 with clear changes in the lung field were selected as subjects. An image interpretation experiment was performed by five image interpreters. Pulmonary emphysema was followed up using two types of thick slab MinIP (thick slab MinIP 1 and 2) and multi-planar reformation (MPR), and the results of image interpretation were evaluated by receiver operating characteristic (ROC) analysis. In addition, the time required for image interpretation was compared among the three follow-up methods. The area under the ROC curve (Az) was 0.794 for thick slab MinIP 1, 0.778 for the thick slab MinIP 2, and 0.759 for MPR, showing no significant differences among the three methods. Individual differences in each item were significantly more marked for MPR than for thick slab MinIP. The time required for image interpretation was around 18 seconds for thick slab MinIP 1, 11 seconds for thick slab MinIP 2, and approximately 127 seconds for MPR, showing significant differences among the three methods. There were no significant differences in the results of image interpretation regarding the presence or absence of changes in the lung fields between thick slab MinIP and MPR. However, thick slab MinIP showed a shorter image interpretation time and smaller individual differences in the results among image interpreters than MPR, suggesting the usefulness of this method for determining the presence or absence of changes with time in the lung fields of patients with pulmonary emphysema.

  19. En australsk øjenåbner

    DEFF Research Database (Denmark)

    Ingemann, Jan Holm

    2008-01-01

    I Europæisk sammenhæng er vi vant til at tænke, at økologisk jordbrug er certificeret. Det skyldes, at certificering er forudsætning for merpris og for særlige subsidier. I Australien er subsidier stort set fraværende, og en lang række producenter anvender følgelig økologiske metoder uden at være...

  20. Farmand i trøjen

    DEFF Research Database (Denmark)

    Schubart, Rikke

    2008-01-01

    Artikel om den amerikanske soldat som far-heltefigur (Daddy Soldier) i den amerikanske krigsfilm fra 1991-2008 Udgivelsesdato: summer......Artikel om den amerikanske soldat som far-heltefigur (Daddy Soldier) i den amerikanske krigsfilm fra 1991-2008 Udgivelsesdato: summer...

  1. Støjen bliver synlig

    DEFF Research Database (Denmark)

    Rindel, Jens Holger

    1997-01-01

    A draft standard INSTA 122:1997 on sound classification of dwellings is for voting as a common national standard in the Nordic countries (Denmark, Norway, Sweden, Finland, Iceland) and in Estonia. The draft standard specifies a sound classification system with four classes A, B, C and D, where cl...... class C is proposed as the future minimum requirements for new dwellings. The classification system is based on limit values for airborne sound insulation, impact sound pressure level, reverberation time and indoor and outdoor noise levels.......A draft standard INSTA 122:1997 on sound classification of dwellings is for voting as a common national standard in the Nordic countries (Denmark, Norway, Sweden, Finland, Iceland) and in Estonia. The draft standard specifies a sound classification system with four classes A, B, C and D, where...

  2. Projekt "Challenger" / Jens Schröder

    Index Scriptorium Estoniae

    Schröder, Jens, 1961-

    2010-01-01

    See oli okeanoloogia ajaloo esimene mastaapne teadusprojekt. 1872. aastal asus Briti korvett "HMS Challenger" teele kolme ja poole aastasele ekspeditsioonile ümber maakera. Teadlased uurisid võõraid rahvaid ja ookeanimaailma

  3. Obhájené dizertace 2016

    Czech Academy of Sciences Publication Activity Database

    Jáchimová, Veronika

    2017-01-01

    Roč. 65, č. 1 (2017), s. 163-165 ISSN 0009-0468 R&D Projects: GA MŠk(CZ) LM2015059 Institutional support: RVO:68378068 Keywords : Czech literature * dissertation Subject RIV: AJ - Letters, Mass-media, Audiovision OBOR OECD: Specific literatures

  4. Skolko pogibshihh v Tshetshenskoi voine? / Jens Hartmann

    Index Scriptorium Estoniae

    Hartmann, Jens

    2005-01-01

    Tšetšeenia Riiginõukogu esimehe Tauss Dzhabrailovi sõnul on kahe Tšetšeenia sõja vältel hukkunud 160 000 inimest. Inimõigusorganisatsiooni Memorial andmetel aga tapeti kahe sõja vältel 75 000 tsiviilisikut ja 14 000 sõjaväelast

  5. TIA model is attainable in Wistar rats by intraluminal occlusion of the MCA for 10min or shorter.

    Science.gov (United States)

    Durukan Tolvanen, A; Tatlisumak, E; Pedrono, E; Abo-Ramadan, U; Tatlisumak, T

    2017-05-15

    Transient ischemic attack (TIA) has received only little attention in the experimental research field. Recently, we introduced a TIA model for mice, and here we set similar principles for simulating this human condition in Wistar rats. In the model: 1) transient nature of the event is ensured, and 2) 24h after the event animals are free from any sensorimotor deficit and from any detectable lesion by magnetic resonance imaging (MRI). Animals experienced varying durations of ischemia (5, 10, 12.5, 15, 25, and 30min, n=6-8pergroup) by intraluminal middle cerebral artery occlusion (MCAO). Ischemia severity and reperfusion rates were controlled by cerebral blood flow measurements. Sensorimotor neurological evaluations and MRI at 24h differentiated between TIA and ischemic stroke. Hematoxylin and eosin staining and apoptotic cell counts revealed pathological correlates of the event. We found that already 12.5min of ischemia was long enough to induce ischemic stroke in Wistar rats. Ten min or shorter durations induced neither gross neurological deficits nor infarcts visible on MRI, but histologically caused selective neuronal necrosis. A separate group of animals with 10min of ischemia followed up to 1week after reperfusion remained free of infarction and any MRI signal change. Thus, 10min or shorter focal cerebral ischemia induced by intraluminal MCAO in Wistar rats provides a clinically relevant TIA the rat. This model is useful for studying molecular correlates of TIA. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Phenotypic and gene expression changes between low (glucose-responsive) and High (glucose non-responsive) MIN-6 beta cells

    DEFF Research Database (Denmark)

    O´Driscoll, L.; Gammell, p.; McKierman, E.

    2006-01-01

    The long-term potential to routinely use replacement beta cells/islets as cell therapy for type 1 diabetes relies on our ability to culture such cells/islets, in vitro, while maintaining their functional status. Previous beta cell studies, by ourselves and other researchers, have indicated...... that the glucose-stimulated insulin secretion (GSIS) phenotype is relatively unstable, in long-term culture. This study aimed to investigate phenotypic and gene expression changes associated with this loss of GSIS, using the MIN-6 cell line as model. Phenotypic differences between MIN-6(L, low passage) and MIN-6(H......, high passage) were determined by ELISA (assessing GSIS and cellular (pro)insulin content), proliferation assays, phase contrast light microscopy and analysis of alkaline phosphatase expression. Differential mRNA expression was investigated using microarray, bioinformatics and real-time PCR technologies...

  7. Measurement of left ventricular ejection fraction with ionic sup(113m)In and a cardiac probe

    Energy Technology Data Exchange (ETDEWEB)

    Liu, X.; Harrison, K.S.; Wagner, H.N. Jr.

    1982-09-01

    Left ventricular ejection fraction (LVEF) was measured with a cardiac probe (Nuclear Stethoscope. Bios Inc., Valhalla, New York) and sup(113m)In in 28 normal subjects and 86 patients with coronary artery disease (CAD). In 20 normal subjects sup(99m)TC-RBCs were compared with sup(113m)In, which binds to transferrin after IV injection. With sup(99m)Tc-RBCs average LVEF was 57+-7% (1 SD); with sup(113m)In, average LEVF was 55+-8% (N.S.). Sequential measurements at different times over 60 min revealed good reproducibility. Comparison of LVEF's obtained using sup(99m)Tc-RBCs with a gamma camera and cardiac probe revealed a good correlation. The correlation coefficients were 0.92 in 25 patients with CAD and 0.95 in 10 patients with LV wall motion abnormalities. The LVEF obtained using a cardiac probe and sup(113m)In increased in 28 normals from 57+-9% to 64+-13% (P<0.001) during handgrip exercise, while the LVEF decreased from 45+-9% to 41+-10% (P<0.01) in patients with acute myocardial infarction 4-7 weeks after episode, from 48+-11 to 40+-12% (P<0.001) in patients with old myocardial infarction, and from 52+-9 to 42+-9% (P<0.001) in patients with angina pectoris. The cardiac probe and sup(113m)In provide a useful alternate means of determining left ventricular dysfunction in facilities where sup(99m)Tc and a gamma camera computer system are not readily available.

  8. Measurement of left ventricular ejection fraction with ionic sup(113m)In and a cardiac probe

    International Nuclear Information System (INIS)

    Liu, X.; Harrison, K.S.; Wagner, H.N. Jr.

    1982-01-01

    Left ventricular ejection fraction (LVEF) was measured with a cardiac probe (Nuclear Stethoscope. Bios Inc., Valhalla, New York) and sup(113m)In in 28 normal subjects and 86 patients with coronary artery disease (CAD). In 20 normal subjects sup(99m)TC-RBCs were compared with sup(113m)In, which binds to transferrin after IV injection. With sup(99m)Tc-RBCs average LVEF was 57+-7% (1 SD); with sup(113m)In, average LEVF was 55+-8% (N.S.). Sequential measurements at different times over 60 min revealed good reproducibility. Comparison of LVEF's obtained using sup(99m)Tc-RBCs with a gamma camera and cardiac probe revealed a good correlation. The correlation coefficients were 0.92 in 25 patients with CAD and 0.95 in 10 patients with LV wall motion abnormalities. The LVEF obtained using a cardiac probe and sup(113m)In increased in 28 normals from 57+-9% to 64+-13% (P<0.001) during handgrip exercise, while the LVEF decreased from 45+-9% to 41+-10% (P<0.01) in patients with acute myocardial infarction 4-7 weeks after episode, from 48+-11 to 40+-12% (P<0.001) in patients with old myocardial infarction, and from 52+-9 to 42+-9% (P<0.001) in patients with angina pectoris. The cardiac probe and sup(113m)In provide a useful alternate means of determining left ventricular dysfunction in facilities where sup(99m)Tc and a gamma camera computer system are not readily available. (orig.)

  9. Astrobiological Significance of Definitive Mineralogical Analysis of Martian Surface Samples Using the CheMin XRD/XRF Instrument

    Science.gov (United States)

    Feldman, S. M.; Blake, D. F.; Sarrazin, P.; Bish, D. L.; Chipera, S. J.; Vaniman, D. T.; Collins, S.

    2004-01-01

    The search for evidence of habitability, or of extant or extinct life on Mars, will initially be a search for evidence of past or present conditions supportive of life. The three key requirements for the emergence of life are thought to be liquid water; a suitable energy source; and chemical building blocks. CheMin is a miniaturized XRD/XRF (X-Ray diffraction / X-ray fluorescence) instrument which has been developed for definitive mineralogic analysis of soils and rocks on the Martian surface. The CheMin instrument can provide information that is highly relevant to each of these habitability requirements as summarized below.

  10. Nonconvergence of the plain Newton-min algorithm for linear complementarity problems with a P-matrix --- The full report.

    OpenAIRE

    Ben Gharbia , Ibtihel; Gilbert , Jean Charles

    2012-01-01

    The plain Newton-min algorithm to solve the linear complementarity problem (LCP for short) 0 ≤ x ⊥ (Mx+q) ≥ 0 can be viewed as a nonsmooth Newton algorithm without globalization technique to solve the system of piecewise linear equations min(x,Mx+q)=0, which is equivalent to the LCP. When M is an M-matrix of order n, the algorithm is known to converge in at most n iterations. We show in this paper that this result no longer holds when M is a P-matrix of order ≥ 3, since then the algorithm may...

  11. Effective photoexcitation cross section of 115In(γ,γ′115mIn from photoactivation data

    Directory of Open Access Journals (Sweden)

    Versteegen M.

    2016-01-01

    Full Text Available Photoexcitation yields of the 115mIn metastable state were measured with Bremsstrahlung γ beams over a range of endpoint energies between 4.5 and 18 MeV. An effective cross section of the 115In(γ,γ′115mIn photoexcitation cross section was determinedto reproduce the data. This cross section is built from a cross section calculated with the TALYS code, to which an enhancement is added at about 8.5 MeV.

  12. The Instruments and Capabilities of the Miniature X-Ray Solar Spectrometer (MinXSS) CubeSats

    Science.gov (United States)

    Moore, Christopher S.; Caspi, Amir; Woods, Thomas N.; Chamberlin, Phillip C.; Dennis, Brian R.; Jones, Andrew R.; Mason, James P.; Schwartz, Richard A.; Tolbert, Anne K.

    2018-02-01

    The Miniature X-ray Solar Spectrometer (MinXSS) CubeSat is the first solar science oriented CubeSat mission flown for the NASA Science Mission Directorate, with the main objective of measuring the solar soft X-ray (SXR) flux and a science goal of determining its influence on Earth's ionosphere and thermosphere. These observations can also be used to investigate solar quiescent, active region, and flare properties. The MinXSS X-ray instruments consist of a spectrometer, called X123, with a nominal 0.15 keV full-width at half-maximum (FWHM) resolution at 5.9 keV and a broadband X-ray photometer, called XP. Both instruments are designed to obtain measurements from 0.5 - 30 keV at a nominal time cadence of 10 s. A description of the MinXSS instruments, performance capabilities, and relation to the Geostationary Operational Environmental Satellite (GOES) 0.1 - 0.8 nm flux is given in this article. Early MinXSS results demonstrate the capability of measuring variations of the solar spectral soft X-ray (SXR) flux between 0.8 - 12 keV from at least GOES A5-M5 (5 × 10^{-8} - 5 ×10^{-5} W m^{-2}) levels and of inferring physical properties (temperature and emission measure) from the MinXSS data alone. Moreover, coronal elemental abundances can be inferred, specifically for Fe, Ca, Si, Mg, S, Ar, and Ni, when the count rate is sufficiently high at each elemental spectral feature. Additionally, temperature response curves and emission measure loci demonstrate the MinXSS sensitivity to plasma emission at different temperatures. MinXSS observations coupled with those from other solar observatories can help address some of the most compelling questions in solar coronal physics. Finally, simultaneous observations by MinXSS and the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) can provide the most spectrally complete soft X-ray solar flare photon flux measurements to date.

  13. MODIS/Aqua Temperature and Water Vapor Profiles 5-Min L2 Swath 5km V006

    Data.gov (United States)

    National Aeronautics and Space Administration — MODIS/Aqua Temperature and Water Vapor Profiles 5-Min L2 Swath 5km (MYD07_L2). MODIS was launched aboard the Aqua satellite on May 04, 2002 (1:30 pm equator crossing...

  14. An Optimal Free Energy Dissipation Strategy of the MinCDE Oscillator in Regulating Symmetric Bacterial Cell Division

    Science.gov (United States)

    Xiong, Liping; Lan, Ganhui

    2015-01-01

    Sustained molecular oscillations are ubiquitous in biology. The obtained oscillatory patterns provide vital functions as timekeepers, pacemakers and spacemarkers. Models based on control theory have been introduced to explain how specific oscillatory behaviors stem from protein interaction feedbacks, whereas the energy dissipation through the oscillating processes and its role in the regulatory function remain unexplored. Here we developed a general framework to assess an oscillator’s regulation performance at different dissipation levels. Using the Escherichia coli MinCDE oscillator as a model system, we showed that a sufficient amount of energy dissipation is needed to switch on the oscillation, which is tightly coupled to the system’s regulatory performance. Once the dissipation level is beyond this threshold, unlike stationary regulators’ monotonic performance-to-cost relation, excess dissipation at certain steps in the oscillating process damages the oscillator’s regulatory performance. We further discovered that the chemical free energy from ATP hydrolysis has to be strategically assigned to the MinE-aided MinD release and the MinD immobilization steps for optimal performance, and a higher energy budget improves the robustness of the oscillator. These results unfold a novel mode by which living systems trade energy for regulatory function. PMID:26317492

  15. Xanthomonas citri MinC Oscillates from Pole to Pole to Ensure Proper Cell Division and Shape

    NARCIS (Netherlands)

    Soibelmann Glock Lorenzoni, André; Dantas, Giordanni; Bergsma, Tessa; Ferreira, Henrique; Scheffers, Dirk

    2017-01-01

    Xanthomonas citri (Xac) is the causal agent of citrus canker, a disease that affects citrus crops and causes economic impact worldwide. To further characterize cell division in this plant pathogen, we investigated the role of the protein MinC in cell division, chromosome segregation, and

  16. Influence des substrats carbonés et minéraux sur l'activité des ...

    African Journals Online (AJOL)

    p < 0.0001). BLIS were stable to heat treatment ranging from 50 °C to 100 °C for 30 min. Conclusion and application of findings: These inhibitory substances produced, could be bacteriocins and could contribute to a better food preservation.

  17. Acute effects of 15min static or contract-relax stretching modalities on plantar flexors neuromuscular properties.

    Science.gov (United States)

    Babault, Nicolas; Kouassi, Blah Y L; Desbrosses, Kevin

    2010-03-01

    The present study aimed to investigate the immediate effects of 15 min static or sub-maximal contract-relax stretching modalities on the neuromuscular properties of plantar flexor muscles. Ten male volunteers were tested before and immediately after 15 min static or contract-relax stretching programs of plantar flexor muscles (20 stretches). Static stretching consisted in 30s stretches to the point of discomfort. For the contract-relax stretching modality, subjects performed 6s sub-maximal isometric plantar flexion before 24s static stretches. Measurements included maximal voluntary isometric torque (MVT) and the corresponding electromyographic activity of soleus (SOL) and medial gastrocnemius (MG) muscles (RMS values), as well as maximal peak torque (Pt) elicited at rest by single supramaximal electrical stimulation of the tibial nerve. After 15 min stretching, significant MVT and SOL RMS decreases were obtained (-6.9+/-11.6% and -6.5+/-15.4%, respectively). No difference was obtained between stretching modalities. Pt remained unchanged after stretching. MG RMS changes were significantly different between stretching modalities (-9.4+/-18.3% and +3.5+/-11.6% after static and contract-relax stretching modalities, respectively). These findings indicated that performing 15 min static or contract-relax stretching had detrimental effects on the torque production capacity of plantar flexor muscles and should be precluded before competition. Mechanisms explaining this alteration seemed to be stretch modality dependent. Copyright 2009 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  18. Using an implicit min/max KD-Tree for doing efficient terrain line of sight calculations

    CSIR Research Space (South Africa)

    Duvenhage, B

    2009-02-01

    Full Text Available -dimensional tree (kd-tree) based raytracing approach, to calculating LOS information, is efficient. A new implicit min/max kd-tree algorithm is discussed for evaluating LOS queries on large scale spherical terrain. In particular the value of low resolution boundary...

  19. The Novel Attempt for Finding Minimum Solution in Fuzzy Neutrosophic Relational Geometric Programming (FNRGP with (max,min Composition

    Directory of Open Access Journals (Sweden)

    Huda E. Khalid

    2016-08-01

    Full Text Available This article sheds light on the possibility of finding the minimum solution set of neutrosophic relational geometric programming with (max, min composition. This work examines the privacy enjoyed by both neutrosophic logic and geometric programming, and how it affects the minimum solutions.

  20. Sleep inertia associated with a 10-min nap before the commute home following a night shift: A laboratory simulation study.

    Science.gov (United States)

    Hilditch, Cassie J; Dorrian, Jillian; Centofanti, Stephanie A; Van Dongen, Hans P; Banks, Siobhan

    2017-02-01

    Night shift workers are at risk of road accidents due to sleepiness on the commute home. A brief nap at the end of the night shift, before the commute, may serve as a sleepiness countermeasure. However, there is potential for sleep inertia, i.e. transient impairment immediately after awakening from the nap. We investigated whether sleep inertia diminishes the effectiveness of napping as a sleepiness countermeasure before a simulated commute after a simulated night shift. N=21 healthy subjects (aged 21-35 y; 12 females) participated in a 3-day laboratory study. After a baseline night, subjects were kept awake for 27h for a simulated night shift. They were randomised to either receive a 10-min nap ending at 04:00 plus a 10-min pre-drive nap ending at 07:10 (10-NAP) or total sleep deprivation (NO-NAP). A 40-min York highway driving task was performed at 07:15 to simulate the commute. A 3-min psychomotor vigilance test (PVT-B) and the Samn-Perelli Fatigue Scale (SP-Fatigue) were administered at 06:30 (pre-nap), 07:12 (post-nap), and 07:55 (post-drive). In the 10-NAP condition, total pre-drive nap sleep time was 9.1±1.2min (mean±SD), with 1.3±1.9min spent in slow wave sleep, as determined polysomnographically. There was no difference between conditions in PVT-B performance at 06:30 (before the nap). In the 10-NAP condition, PVT-B performance was worse after the nap (07:12) compared to before the nap (06:30); no change across time was found in the NO-NAP condition. There was no significant difference between conditions in PVT-B performance after the drive. SP-Fatigue and driving performance did not differ significantly between conditions. In conclusion, the pre-drive nap showed objective, but not subjective, evidence of sleep inertia immediately after awakening. The 10-min nap did not affect driving performance during the simulated commute home, and was not effective as a sleepiness countermeasure. Copyright © 2015 Elsevier Ltd. All rights reserved.

  1. Voluntary exercise inhibits intestinal tumorigenesis in ApcMin/+ mice and azoxymethane/dextran sulfate sodium-treated mice

    International Nuclear Information System (INIS)

    Ju, Jihyeung; Nolan, Bonnie; Cheh, Michelle; Bose, Mousumi; Lin, Yong; Wagner, George C; Yang, Chung S

    2008-01-01

    Epidemiological studies suggest that physical activity reduces the risk of colon cancer in humans. Results from animal studies, however, are inconclusive. The present study investigated the effects of voluntary exercise on intestinal tumor formation in two different animal models, Apc Min/+ mice and azoxymethane (AOM)/dextran sulfate sodium (DSS)-treated mice. In Experiments 1 and 2, five-week old female Apc Min/+ mice were either housed in regular cages or cages equipped with a running wheel for 6 weeks (for mice maintained on the AIN93G diet; Experiment 1) or 9 weeks (for mice on a high-fat diet; Experiment 2). In Experiment 3, male CF-1 mice at 6 weeks of age were given a dose of AOM (10 mg/kg body weight, i.p.) and, 12 days later, 1.5% DSS in drinking fluid for 1 week. The mice were then maintained on a high-fat diet and housed in regular cages or cages equipped with a running wheel for 16 weeks. In the Apc Min/+ mice maintained on either the AIN93G or the high-fat diet, voluntary exercise decreased the number of small intestinal tumors. In the AOM/DSS-treated mice maintained on a high-fat diet, voluntary exercise also decreased the number of colon tumors. In Apc Min/+ mice, voluntary exercise decreased the ratio of serum insulin like growth factor (IGF)-1 to IGF binding protein (BP)-3 levels. It also decreased prostaglandin E 2 and nuclear β-catenin levels, but increased E-cadherin levels in the tumors. These results indicate hat voluntary exercise inhibited intestinal tumorigenesis in Apc Min/+ mice and AOM/DSS-treated mice, and the inhibitory effect is associated with decreased IGF-1/IGFBP-3 ratio, aberrant β-catenin signaling, and arachidonic acid metabolism

  2. Comparison of bacterial genome assembly software for MinION data and their applicability to medical microbiology.

    Science.gov (United States)

    Judge, Kim; Hunt, Martin; Reuter, Sandra; Tracey, Alan; Quail, Michael A; Parkhill, Julian; Peacock, Sharon J

    2016-09-01

    Translating the Oxford Nanopore MinION sequencing technology into medical microbiology requires on-going analysis that keeps pace with technological improvements to the instrument and release of associated analysis software. Here, we use a multidrug-resistant Enterobacter kobei isolate as a model organism to compare open source software for the assembly of genome data, and relate this to the time taken to generate actionable information. Three software tools (PBcR, Canu and miniasm) were used to assemble MinION data and a fourth (SPAdes) was used to combine MinION and Illumina data to produce a hybrid assembly. All four had a similar number of contigs and were more contiguous than the assembly using Illumina data alone, with SPAdes producing a single chromosomal contig. Evaluation of the four assemblies to represent the genome structure revealed a single large inversion in the SPAdes assembly, which also incorrectly integrated a plasmid into the chromosomal contig. Almost 50 %, 80 % and 90 % of MinION pass reads were generated in the first 6, 9 and 12 h, respectively. Using data from the first 6 h alone led to a less accurate, fragmented assembly, but data from the first 9 or 12 h generated similar assemblies to that from 48 h sequencing. Assemblies were generated in 2 h using Canu, indicating that going from isolate to assembled data is possible in less than 48 h. MinION data identified that genes responsible for resistance were carried by two plasmids encoding resistance to carbapenem and to sulphonamides, rifampicin and aminoglycosides, respectively.

  3. Min Morfars Film

    DEFF Research Database (Denmark)

    Juel, Henrik

    1957-01-01

    Reflektioner over filmhistoriebegrebet og gennemgang af konkrete filmoplevelser i 1957 og i nutiden med udgangspunkt i mødet med en gammel familiefilm. Reflektioner over valg af motiver i en social- og personhistorisk dateret film.......Reflektioner over filmhistoriebegrebet og gennemgang af konkrete filmoplevelser i 1957 og i nutiden med udgangspunkt i mødet med en gammel familiefilm. Reflektioner over valg af motiver i en social- og personhistorisk dateret film....

  4. Study of the binding of {sup 114m}In radiotracer to human serum components by ultrafiltration and chromatography

    Energy Technology Data Exchange (ETDEWEB)

    Hulle, M. van; De Cremer, K.; Cornelis, R. [Ghent Rijksuniversiteit (Belgium). Lab. for Analytical Chemistry

    2000-10-01

    The chemical speciation of indium in serum was studied. Ultrafiltration was used to investigate the influence of several buffer systems on the binding characteristics of indium in serum and to study the association of indium with transferrin and albumin. This was performed by means of batch incubation experiments with a {sup 114m}In tracer. Different buffer systems were investigated. A series of bicarbonate, Tris:HCl and HEPES buffers were found to fit for this purpose. Phosphate buffer was not suitable, as it is capable of disrupting the binding between indium and transferrin. Batch ultrafiltration experiments with {sup 114m}In incubated solutions of transferrin and albumin showed that both proteins are capable of binding indium to a high degree. Three chromatographic techniques (SEC, AEC, AC) were used to study the different chemically active species of indium in serum. It is concluded that next to transferrin, albumin is also responsible for the binding and transport of indium in serum. (orig.)

  5. Min-max optimization and the radial approach to the public service system design with generalized utility

    Directory of Open Access Journals (Sweden)

    Jaroslav Janáček

    2016-04-01

    Full Text Available The paper deals with the min-max public service system design, where the generalized utility is considered. In contrast to the formulations presented in the literature, the generalized utility defined for a public service system assumes that the user’s utility comes generally from more than one located service center and the individual contributions from relevant centers are weighted by reduction coefficients depending on a center order. Given that commercial IP-solvers often fail due to enormous computational times or extreme memory demands when resolving this issue, we suggested and compared several approaches based on a bisection process with the purpose of developing an effective max-min approach to the public service system design with a generalized utility.

  6. Max–min-plus expressions for one-dimensional particle cellular automata obtained from a fundamental diagram

    International Nuclear Information System (INIS)

    Okumura, Takazumi; Matsukidaira, Junta; Takahashi, Daisuke

    2013-01-01

    We study one-dimensional neighborhood-five conservative cellular automata (CA), referred to as particle cellular automata five (particle CA5). We show that evolution equations for particle CA5s that belong to certain types can be obtained in the form of max–min-plus expressions from a fundamental diagram. The obtained equations are transformed into other max–min-plus expressions by ultradiscrete Cole–Hopf transformations, which enable us to analyze the asymptotic behaviors of general solutions. The equations in the Lagrange representation, which describe particle motion, are also presented, which can also be obtained from a fundamental diagram. Finally, we discuss the generalization to a one-dimensional conservative neighborhood-n CA, i.e., particle CAn. (paper)

  7. Reagent' sets for the concentration of sup(99m)Tc and sup(113m)In

    International Nuclear Information System (INIS)

    Bianco de Salas, G.N.; Arciprete, J.; Mitta, A.E.A.

    1976-10-01

    A simple technique for the concentration of the eluates from 99 Mo/sup(99m)Tc and 113 Sn/sup(113m)In generators is described. The reagents' sets provided by the C.N.E.A. for the labelling of different radiopharmaceuticals can be used by only reducing their volumes proportionally. Both concentration techniques for Tc-99m and In-113m will be supplied to users as reagents' sets. (author) [es

  8. Anesthetic efficacy of a repeated intraosseous injection given 30 min following an inferior alveolar nerve block/intraosseous injection.

    OpenAIRE

    Reitz, J.; Reader, A.; Nist, R.; Beck, M.; Meyers, W. J.

    1998-01-01

    To determine whether a repeated intraosseous (IO) injection would increase or prolong pulpal anesthesia, we measured the degree of anesthesia obtained by a repeated IO injection given 30 min following a combination inferior alveolar nerve block/intraosseous injection (IAN/IO) in mandibular second premolars and in first and second molars. Using a repeated-measures design, we randomly assigned 38 subjects to receive two combinations of injections at two separate appointments. The combinations w...

  9. 30 min of treadmill walking at self-selected speed does not increase gait variability in independent elderly.

    Science.gov (United States)

    Da Rocha, Emmanuel S; Kunzler, Marcos R; Bobbert, Maarten F; Duysens, Jacques; Carpes, Felipe P

    2018-06-01

    Walking is one of the preferred exercises among elderly, but could a prolonged walking increase gait variability, a risk factor for a fall in the elderly? Here we determine whether 30 min of treadmill walking increases coefficient of variation of gait in elderly. Because gait responses to exercise depend on fitness level, we included 15 sedentary and 15 active elderly. Sedentary participants preferred a lower gait speed and made smaller steps than the actives. Step length coefficient of variation decreased ~16.9% by the end of the exercise in both the groups. Stride length coefficient of variation decreased ~9% after 10 minutes of walking, and sedentary elderly showed a slightly larger step width coefficient of variation (~2%) at 10 min than active elderly. Active elderly showed higher walk ratio (step length/cadence) than sedentary in all times of walking, but the times did not differ in both the groups. In conclusion, treadmill gait kinematics differ between sedentary and active elderly, but changes over time are similar in sedentary and active elderly. As a practical implication, 30 min of walking might be a good strategy of exercise for elderly, independently of the fitness level, because it did not increase variability in step and stride kinematics, which is considered a risk of fall in this population.

  10. Maslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+ mice through transcriptomic and metabolomic reprogramming.

    Directory of Open Access Journals (Sweden)

    Susana Sánchez-Tena

    Full Text Available Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancer-related death in western countries. In this regard, maslinic acid (MA, a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and induce apoptosis in colon cancer cell lines without affecting normal intestinal cells. The present study evaluated the chemopreventive efficacy and associated mechanisms of maslinic acid treatment on spontaneous intestinal tumorigenesis in Apc(Min/+ mice. Twenty-two mice were randomized into 2 groups: control group and MA group, fed with a maslinic acid-supplemented diet for six weeks. MA treatment reduced total intestinal polyp formation by 45% (P<0.01. Putative molecular mechanisms associated with suppressing intestinal polyposis in Apc(Min/+ mice were investigated by comparing microarray expression profiles of MA-treated and control mice and by analyzing the serum metabolic profile using NMR techniques. The different expression phenotype induced by MA suggested that it exerts its chemopreventive action mainly by inhibiting cell-survival signaling and inflammation. These changes eventually induce G1-phase cell cycle arrest and apoptosis. Moreover, the metabolic changes induced by MA treatment were associated with a protective profile against intestinal tumorigenesis. These results show the efficacy and underlying mechanisms of MA against intestinal tumor development in the Apc(Min/+ mice model, suggesting its chemopreventive potential against colorectal cancer.

  11. Assessing the utility of the Oxford Nanopore MinION for snake venom gland cDNA sequencing

    Directory of Open Access Journals (Sweden)

    Adam D. Hargreaves

    2015-11-01

    Full Text Available Portable DNA sequencers such as the Oxford Nanopore MinION device have the potential to be truly disruptive technologies, facilitating new approaches and analyses and, in some cases, taking sequencing out of the lab and into the field. However, the capabilities of these technologies are still being revealed. Here we show that single-molecule cDNA sequencing using the MinION accurately characterises venom toxin-encoding genes in the painted saw-scaled viper, Echis coloratus. We find the raw sequencing error rate to be around 12%, improved to 0–2% with hybrid error correction and 3% with de novo error correction. Our corrected data provides full coding sequences and 5′ and 3′ UTRs for 29 of 33 candidate venom toxins detected, far superior to Illumina data (13/40 complete and Sanger-based ESTs (15/29. We suggest that, should the current pace of improvement continue, the MinION will become the default approach for cDNA sequencing in a variety of species.

  12. Assessing the utility of the Oxford Nanopore MinION for snake venom gland cDNA sequencing.

    Science.gov (United States)

    Hargreaves, Adam D; Mulley, John F

    2015-01-01

    Portable DNA sequencers such as the Oxford Nanopore MinION device have the potential to be truly disruptive technologies, facilitating new approaches and analyses and, in some cases, taking sequencing out of the lab and into the field. However, the capabilities of these technologies are still being revealed. Here we show that single-molecule cDNA sequencing using the MinION accurately characterises venom toxin-encoding genes in the painted saw-scaled viper, Echis coloratus. We find the raw sequencing error rate to be around 12%, improved to 0-2% with hybrid error correction and 3% with de novo error correction. Our corrected data provides full coding sequences and 5' and 3' UTRs for 29 of 33 candidate venom toxins detected, far superior to Illumina data (13/40 complete) and Sanger-based ESTs (15/29). We suggest that, should the current pace of improvement continue, the MinION will become the default approach for cDNA sequencing in a variety of species.

  13. ”Se on tärkeää, että sinä käyt ulkona, et istu vaan kotona ja teet erilaisia asioita.” : tutkimus harrastusten merkityksestä somalityttöjen vapaa-ajassa

    OpenAIRE

    Tikkanen, Noora

    2013-01-01

    Tämän opinnäytetyön tarkoituksena oli tutkia miten yksin Suomeen tulleet ja tälläkin hetkellä ilman perhettään asuvat somalitytöt viettävät vapaa-aikaansa, minkä merkityksen he antavat harrastuksille ja mitkä asiat vaikuttavat harrastustoimintaan osallistumiseen. Tutkimuksen tavoitteena oli löytää keinoja, joilla voitaisiin lisätä Turun ensi- ja turvakoti ry:n perheryhmäkodissa asuvien somalityttöjen harrastusaktiivisuutta, ja edistää näin heidän hyvinvointiaan ja kotoutumistaan. Tutkimus...

  14. Sudden f/sub min/ enhancements and sudden cosmic noise absorptions associated with solar X-ray flares

    Energy Technology Data Exchange (ETDEWEB)

    Sato, T [Hyogo Coll. of Medicine, Hyogo (Japan). Dept. of Physics

    1975-01-01

    Sudden fsub(min) enhancements (SFsub(m)E's) and sudden cosmic noise absorptions (SCNA's) associated with increments of X-ray fluxes during solar flares are studied on the basis of X-ray flux data measured by SOLRAD 9 and 10 satellites. Some statistical analyses on SFsub(m)E's observed at five observatories in Japan, corresponding to increased X-ray fluxes in the 1-8 A band are made for 50 solar flare events during the period January 1972 to December 1973, and value of fsub(min) is expressed as functions of cos x(x; solar zenith angle) and 1-8 A band X-ray flux. Similar study is also made for SCNA's observed by 30 MHz riometer at Hiraiso for 15 great solar flare events during the same period, together with 27.6 MHz riometer data reported by Schwentek (1973) and 18 MHz data published by Deshpande and Mitra (1972b). It is found that fsub(min) value (MHz) and SCNA value (L, dB) of a radio wave with frequency f(MHz) are related to X-ray flux (F/sub 0/, erg cm/sup -2/ sec/sup -1/) in the 1-8 A band and to cos x, by following approximate expressions, fsub(min)(MHz)=10F/sub 0/sup(1/4) cossup(1/2) x, and L(dB)=4.37x10/sup 3/f/sup -2/F/sub 0/sup(1/2) cos x, respectively. Blackout seems to occur for F/sub 0/ values causing fsub(min)'s greater than about 5 MHz. It is shown that these expressions can be derived from a brief theoretical calculation of radio wave absorption in the lower ionosphere. Also it is suggested that threshold X-ray fluxes in the 1-8 A band which may produce a minimum SFsub(m)E (2 MHz), blackout and minimum SCNA (0.27-0.36 dB for 30 MHz noise) are 1.6x10/sup -3/, 6.2x10/sup -2/ and (3-8) x 10/sup -3/ erg cm/sup -2/ sec/sup -1/, respectively, for cos x=1.

  15. Temperature, salinity, sigma_t, pressure measurement collected using CTD from an unknown platform in the Min Fang Bay from 1984 to 1985 (NODC Accession 0048830)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Southern Ocean data - Min Fang Bay , temperature and salinity measurements collected using CTD from unknown platform in the Min Fang Bay from 1984 to 1985

  16. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Neonatal Gastrointestinal Physiology and NEC"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Neonatal Gastrointestinal Physiology and NEC"ABS 1. DETRIMENTAL MUCOSAL EFFECT OF IBUPROFEN IN THE IMMATURE HUMAN INTESTINE • E. Tremblay, E. Ferretti, M.-P. Thibault, D. Grynspan, K.M. Burghardt, M. Bettolli, C. Babakissa, E. Levy, J.-F. Beaulieu; Research Consortium on Child Intestinal InflammationABS 2. CORRELATION BETWEEN CALPROTECTIN LEVELS IN MECONIUM AND VITAMIN D STATUS IN CORD BLOOD: ASSOCIATION WITH INTESTINAL DISTRESS DURING NEONATAL PERIOD • S.H. Park, W.H. Kim, Y.M. LeeABS 3. COMPARISON OF FECAL CALPROTECTIN LEVELS ACCORDING TO FEEDING KINDS IN VERY PRETERM INFANTS • J.H. Park, N.H. Lee, S.Y. Shin, C.S. Kim, S.L. Lee, W.M. LeeABS 4. NEONATAL MORBIDITY OF EXTREME PRETERM INFANTS BEFORE AND AFTER THE INTRODUCTION OF A DONOR HUMAN MILK BANK AT THE PERINATAL CENTER GROßHADERN • V. Lieftüchter, M. Kujawa, A. Schuze, A.W. Flemmer, S. Herber-JonatABS 5. IS NEAR INFRARED SPECTROSCOPY A RELIABLE TECHNIQUE TO MEASURE GUT PERFUSION IN PRETERM INFANTS? • J. Banerjee, T.S. Leung, N. AladangadyABS 6. EARLY BIOCHEMICAL MARKERS ASSOCIATED WITH DEVELOPMENT OF NECROTIZING

  17. New Min-Max Approach to Optimal Choice of the Weights in Multi-Criteria Group Decision-Making Problems

    Directory of Open Access Journals (Sweden)

    Ming Chen

    2015-11-01

    Full Text Available In multi-criteria group decision-making (MCGDM, one of the most important problems is to determine the weights of criteria and experts. This paper intends to present two Min-Max models to optimize the point estimates of the weights. Since each expert generally possesses a uniform viewpoint on the importance (weighted value of each criterion when he/she needs to rank the alternatives, the objective function in the first model is to minimize the maximum variation between the actual score vector and the ideal one for all the alternatives such that the optimal weights of criteria are consistent in ranking all the alternatives for the same expert. The second model is designed to optimize the weights of experts such that the obtained overall evaluation for each alternative can collect the perspectives of the experts as many as possible. Thus, the objective function in the second model is to minimize the maximum variation between the actual vector of evaluations and the ideal one for all the experts, such that the optimal weights can reduce the difference among the experts in evaluating the same alternative. For the constructed Min-Max models, another focus in this paper is on the development of an efficient algorithm for the optimal weights. Some applications are employed to show the significance of the models and algorithm. From the numerical results, it is clear that the developed Min-Max models more effectively solve the MCGDM problems including the ones with incomplete score matrices, compared with the methods available in the literature. Specifically, by the proposed method, (1 the evaluation uniformity of each expert on the same criteria is guaranteed; (2 The overall evaluation for each alternative can collect the judgements of the experts as many as possible; (3 The highest discrimination degree of the alternatives is obtained.

  18. The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+ mouse.

    Directory of Open Access Journals (Sweden)

    James P White

    Full Text Available Muscle wasting that occurs with cancer cachexia is caused by an imbalance in the rates of muscle protein synthesis and degradation. The Apc(Min/+ mouse is a model of colorectal cancer that develops cachexia that is dependent on circulating IL-6. However, the IL-6 regulation of muscle protein turnover during the initiation and progression of cachexia in the Apc(Min/+ mouse is not known. Cachexia progression was studied in Apc(Min/+ mice that were either weight stable (WS or had initial (≤5%, intermediate (6-19%, or extreme (≥20% body weight loss. The initiation of cachexia reduced %MPS 19% and a further ∼50% with additional weight loss. Muscle IGF-1 mRNA expression and mTOR targets were suppressed with the progression of body weight loss, while muscle AMPK phosphorylation (Thr 172, AMPK activity, and raptor phosphorylation (Ser 792 were not increased with the initiation of weight loss, but were induced as cachexia progressed. ATP dependent protein degradation increased during the initiation and progression of cachexia. However, ATP independent protein degradation was not increased until cachexia had progressed beyond the initial phase. IL-6 receptor antibody administration prevented body weight loss and suppressed muscle protein degradation, without any effect on muscle %MPS or IGF-1 associated signaling. In summary, the %MPS reduction during the initiation of cachexia is associated with IGF-1/mTOR signaling repression, while muscle AMPK activation and activation of ATP independent protein degradation occur later in the progression of cachexia. IL-6 receptor antibody treatment blocked cachexia progression through the suppression of muscle protein degradation, while not rescuing the suppression of muscle protein synthesis. Attenuation of IL-6 signaling was effective in blocking the progression of cachexia, but not sufficient to reverse the process.

  19. A database of 10 min average measurements of solar radiation and meteorological variables in Ostrava, Czech Republic

    Directory of Open Access Journals (Sweden)

    M. Opálková

    2018-04-01

    Full Text Available A database containing 10 min means of solar irradiance measured on a horizontal plane in several ultraviolet and visible bands from July 2014 to December 2016 at three stations in the area of the city of Ostrava (Czech Republic is presented. The database contains time series of 10 min average irradiances or photosynthetic photon flux densities measured in the following spectral bands: 280–315 nm (UVB; 315–380 nm (UVA; and 400–700 nm (photosynthetically active radiation, PAR; 510–700 nm; 600–700 nm; 610–680 nm; 690–780 nm; 400–1100 nm. A series of meteorological variables including relative air humidity and air temperature at surface is also provided at the same 10 min time step at all three stations, and precipitation is provided for two stations. Air pressure, wind speed, wind direction, and concentrations of air pollutants PM10, SO2, NOx, NO, NO2 were measured at the 1 h time step at the fourth station owned by the Public Health Institute of Ostrava. The details of the experimental sites and instruments used for the measurements are given. Special attention is given to the data quality, and the original approach to the data quality which was established is described in detail. About 130 000 records for each of the three stations are available in the database. This database offers a unique ensemble of variables having a high temporal resolution and it is a reliable source for radiation in relation to environment and vegetation in highly polluted areas of industrial cities in the of northern mid-latitudes. The database has been placed on the PANGAEA repository (https://doi.org/10.1594/PANGAEA.879722 and contains individual data files for each station.

  20. Radioactive Indium({sup 114m}In) complexes derived thiosemicarbazones for development of glioma radionuclide therapy tools

    Energy Technology Data Exchange (ETDEWEB)

    Ribeiro, Thais S.; Menezes, Maria Ângela B.C.; Belo, Luiz Cláudio M.; Santos, Raquel G. dos, E-mail: thaissribeiro01@gmail.com, E-mail: lcmb@cdtn.br, E-mail: menezes@cdtn.br, E-mail: gouvears@gmail.com [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Franco, Lucas L.; Oliveira, Alexandre A.; Beraldo, Heloisa O., E-mail: lucas_lopardi@yahoo.com.br, E-mail: a13xandr31@hotmail.com, E-mail: heloisaberaldoufmg@gmail.com [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Química

    2017-07-01

    Chemotherapy is widely used as the main course of treatment for various types of cancer. However, the side effects derived from the prolonged use of highly cytotoxic drugs in association with chemotherapy induced resistance are important challenges for effective therapy. In this context, radionuclide therapy (RNT) can be an alternative way to decrease the toxicity and improve the specificity of anti tumoral drugs. Our group has recently demonstrated that Indium (III) coordination to N(4)-Tolyl-2-acetylpyridine-derived thiosemicarbazones improves cytotoxic effects on leukemia cell lines. Once {sup 114m}In is a prolific Auger electron emitter, in this study In (III) complexes and their radioactive analogs were produced by neutron activation and their potential for RNT was further studied. Native and radioactive complexes were tested in different concentrations in U87 and T98 glioblastoma multiform (GBM) cell lines, as well as in MRC5 fibroblast cell line. All drugs presented a dose dependent cytotoxicity against cancer cells at submicromolar concentrations. The treatment with 1 μM of the radioactive analogs containing {sup 114m}In proved to be at least 1.5 times more potent than non-radioactive complexes in GBM cell lines. Due to the innate resistance of glioblastomas to chemotherapy and radiotherapy, the potentiation factor showed by the test radioactive complexes may be interesting in the course of treatment against these tumors. Therefore, the presented data suggests a synergistic effect of the radionuclide therapy conducted in this study, which might be due to the combinations of pharmacological and radiotherapeutic activities of the {sup 114m}In - thiosemicarbazone compounds. (author)

  1. Safely prolonging single breath-holds to >5 min in patients with cancer; feasibility and applications for radiotherapy

    Science.gov (United States)

    Green, Stuart; Stevens, Andrea M; Parveen, Sophia; Stephens, Rebecca; Clutton-Brock, Thomas H

    2016-01-01

    Objective: Multiple, short and deep inspiratory breath-holds with air of approximately 20 s are now used in radiotherapy to reduce the influence of ventilatory motion and damage to healthy tissue. There may be further clinical advantages in delivering each treatment session in only one single, prolonged breath-hold. We have previously developed techniques enabling healthy subjects to breath-hold for 7 min. Here, we demonstrate their successful application in patients with cancer. Methods: 15 patients aged 37–74 years undergoing radiotherapy for breast cancer were trained to breath-hold safely with pre-oxygenation and mechanically induced hypocapnia under simulated radiotherapy treatment conditions. Results: The mean breath-hold duration was 5.3 ± 0.2 min. At breakpoint, all patients were normocapnic and normoxic [mean end-tidal partial pressure of carbon dioxide was 36 ± 1 standard error millimetre of mercury, (mmHg) and mean oxygen saturation was 100 ± 0 standard error %]. None were distressed, nor had gasping, dizziness or disturbed breathing in the post-breath-hold period. Mean blood pressure had risen significantly from 125 ± 3 to 166 ± 4 mmHg at breakpoint (without heart rate falling), but normalized within approximately 20 s of the breakpoint. During breath-holding, the mean linear anteroposterior displacement slope of the L breast marker was radiotherapy treatment conditions for longer than the typical beam-on time of a single fraction. We discuss the important applications of this technique for radiotherapy. Advances in knowledge: We demonstrate for the first time a technique enabling patients with cancer to deliver safely a single prolonged breath-hold of >5 min (10 times longer than currently used in radiotherapy practice), under simulated radiotherapy treatment conditions. PMID:27168468

  2. Assessment of aortitis by semiquantitative analysis of 180-min {sup 18}F-FDG PET/CT acquisition images

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Rodriguez, Isabel [University of Cantabria, Department of Nuclear Medicine, Marques de Valdecilla University Hospital, Santander (Spain); Hospital Universitario Marques de Valdecilla, S. Medicina Nuclear, Santander (Spain); Martinez-Amador, N.; Banzo, I.; Quirce, R.; Jimenez-Bonilla, J.; Arcocha-Torres, M. de; Ibanez-Bravo, S.; Lavado-Perez, C.; Bravo-Ferrer, Z.; Carril, J.M. [University of Cantabria, Department of Nuclear Medicine, Marques de Valdecilla University Hospital, Santander (Spain); Blanco, R.; Gonzalez-Gay, M.A. [University of Cantabria, Department of Rheumatology, Marques de Valdecilla University Hospital, Santander (Spain)

    2014-12-15

    The aim of this study was to evaluate the contribution of semiquantitative analysis of 180-min {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT images for the assessment of aortitis in cases of suspected large vessel vasculitis (LVV) and to establish a threshold index for application in the clinical setting. This prospective study included 43 patients (mean age 67.5 ± 12.9 years) with suspicion of LVV (25 with a final diagnosis of aortitis). {sup 18}F-FDG PET/CT scan was acquired 180 min after injection of 7 MBq/kg of {sup 18}F-FDG. A semiquantitative analysis was performed calculating the aortic wall maximum standardized uptake value (SUV{sub max}) (T), the lumen SUV{sub max} (B) and the target to background ratio (TBR). These results were also compared with those obtained in a control population. The mean aortic wall SUV{sub max} was 2.00 ± 0.62 for patients with aortitis and 1.45 ± 0.31 for patients without aortitis (p < 0.0001). The TBR was 1.66 ± 0.26 for patients with aortitis and 1.24 ± 0.08 for patients without aortitis (p < 0.0001). The differences were also statistically significant when the patients with aortitis and controls were compared. Receiver-operating characteristic (ROC) analysis revealed that the area under the curve was greater for the TBR than for the aortic wall SUV{sub max} (0.997 vs 0.871). The highest sensitivity and specificity was obtained for a TBR of 1.34 (sensitivity 100 %, specificity 94.4 %). Semiquantitative analysis of PET/CT images acquired 180 min after {sup 18}F-FDG injection and the TBR index of 1.34 show very high accuracy and, therefore, are strongly recommended for the diagnosis of aortitis in the clinical setting. (orig.)

  3. Genotoxic effects of high dose rate X-ray and low dose rate gamma radiation in ApcMin/+ mice.

    Science.gov (United States)

    Graupner, Anne; Eide, Dag M; Brede, Dag A; Ellender, Michele; Lindbo Hansen, Elisabeth; Oughton, Deborah H; Bouffler, Simon D; Brunborg, Gunnar; Olsen, Ann Karin

    2017-10-01

    Risk estimates for radiation-induced cancer in humans are based on epidemiological data largely drawn from the Japanese atomic bomb survivor studies, which received an acute high dose rate (HDR) ionising radiation. Limited knowledge exists about the effects of chronic low dose rate (LDR) exposure, particularly with respect to the application of the dose and dose rate effectiveness factor. As part of a study to investigate the development of colon cancer following chronic LDR vs. acute HDR radiation, this study presents the results of genotoxic effects in blood of exposed mice. CBAB6 F1 Apc +/+ (wild type) and Apc Min/+ mice were chronically exposed to estimated whole body absorbed doses of 1.7 or 3.2 Gy 60 Co-γ-rays at a LDR (2.2 mGy h -1 ) or acutely exposed to 2.6 Gy HDR X-rays (1.3 Gy min -1 ). Genotoxic endpoints assessed in blood included chromosomal damage (flow cytometry based micronuclei (MN) assay), mutation analyses (Pig-a gene mutation assay), and levels of DNA lesions (Comet assay, single-strand breaks (ssb), alkali labile sites (als), oxidized DNA bases). Ionising radiation (ca. 3 Gy) induced genotoxic effects dependent on the dose rate. Chromosomal aberrations (MN assay) increased 3- and 10-fold after chronic LDR and acute HDR, respectively. Phenotypic mutation frequencies as well as DNA lesions (ssb/als) were modulated after acute HDR but not after chronic LDR. The Apc Min/+ genotype did not influence the outcome in any of the investigated endpoints. The results herein will add to the scant data available on genotoxic effects following chronic LDR of ionising radiation. Environ. Mol. Mutagen. 58:560-569, 2017. © 2017 The Authors Environmental and Molecular Mutagenesis published by Wiley Periodicals, Inc. on behalf of Environmental Mutagen Society. © 2017 The Authors Environmental and Molecular Mutagenesis published by Wiley Periodicals, Inc. on behalf of Environmental Mutagen Society.

  4. The Regulation of Skeletal Muscle Protein Turnover during the Progression of Cancer Cachexia in the ApcMin/+ Mouse

    Science.gov (United States)

    White, James P.; Baynes, John W.; Welle, Stephen L.; Kostek, Matthew C.; Matesic, Lydia E.; Sato, Shuichi; Carson, James A.

    2011-01-01

    Muscle wasting that occurs with cancer cachexia is caused by an imbalance in the rates of muscle protein synthesis and degradation. The ApcMin/+ mouse is a model of colorectal cancer that develops cachexia that is dependent on circulating IL-6. However, the IL-6 regulation of muscle protein turnover during the initiation and progression of cachexia in the ApcMin/+ mouse is not known. Cachexia progression was studied in ApcMin/+ mice that were either weight stable (WS) or had initial (≤5%), intermediate (6–19%), or extreme (≥20%) body weight loss. The initiation of cachexia reduced %MPS 19% and a further ∼50% with additional weight loss. Muscle IGF-1 mRNA expression and mTOR targets were suppressed with the progression of body weight loss, while muscle AMPK phosphorylation (Thr 172), AMPK activity, and raptor phosphorylation (Ser 792) were not increased with the initiation of weight loss, but were induced as cachexia progressed. ATP dependent protein degradation increased during the initiation and progression of cachexia. However, ATP independent protein degradation was not increased until cachexia had progressed beyond the initial phase. IL-6 receptor antibody administration prevented body weight loss and suppressed muscle protein degradation, without any effect on muscle %MPS or IGF-1 associated signaling. In summary, the %MPS reduction during the initiation of cachexia is associated with IGF-1/mTOR signaling repression, while muscle AMPK activation and activation of ATP independent protein degradation occur later in the progression of cachexia. IL-6 receptor antibody treatment blocked cachexia progression through the suppression of muscle protein degradation, while not rescuing the suppression of muscle protein synthesis. Attenuation of IL-6 signaling was effective in blocking the progression of cachexia, but not sufficient to reverse the process. PMID:21949739

  5. Short-term pyrrolidine dithiocarbamate administration attenuates cachexia-induced alterations to muscle and liver in ApcMin/+ mice.

    Science.gov (United States)

    Narsale, Aditi A; Puppa, Melissa J; Hardee, Justin P; VanderVeen, Brandon N; Enos, Reilly T; Murphy, E Angela; Carson, James A

    2016-09-13

    Cancer cachexia is a complex wasting condition characterized by chronic inflammation, disrupted energy metabolism, and severe muscle wasting. While evidence in pre-clinical cancer cachexia models have determined that different systemic inflammatory inhibitors can attenuate several characteristics of cachexia, there is a limited understanding of their effects after cachexia has developed, and whether short-term administration is sufficient to reverse cachexia-induced signaling in distinctive target tissues. Pyrrolidine dithiocarbamate (PDTC) is a thiol compound having anti-inflammatory and antioxidant properties which can inhibit STAT3 and nuclear factor κB (NF-κB) signaling in mice. This study examined the effect of short-term PDTC administration to ApcMin/+ mice on cachexia-induced disruption of skeletal muscle protein turnover and liver metabolic function. At 16 weeks of age ApcMin/+ mice initiating cachexia (7% BW loss) were administered PDTC (10mg/kg bw/d) for 2 weeks. Control ApcMin/+ mice continued to lose body weight during the treatment period, while mice receiving PDTC had no further body weight decrease. PDTC had no effect on either intestinal tumor burden or circulating IL-6. In muscle, PDTC rescued signaling disrupting protein turnover regulation. PDTC suppressed the cachexia induction of STAT3, increased mTORC1 signaling and protein synthesis, and suppressed the induction of Atrogin-1 protein expression. Related to cachectic liver metabolic function, PDTC treatment attenuated glycogen and lipid content depletion independent to the activation of STAT3 and mTORC1 signaling. Overall, these results demonstrate short-term PDTC treatment to cachectic mice attenuated cancer-induced disruptions to muscle and liver signaling, and these changes were independent to altered tumor burden and circulating IL-6.

  6. A database of 10 min average measurements of solar radiation and meteorological variables in Ostrava, Czech Republic

    Science.gov (United States)

    Opálková, Marie; Navrátil, Martin; Špunda, Vladimír; Blanc, Philippe; Wald, Lucien

    2018-04-01

    A database containing 10 min means of solar irradiance measured on a horizontal plane in several ultraviolet and visible bands from July 2014 to December 2016 at three stations in the area of the city of Ostrava (Czech Republic) is presented. The database contains time series of 10 min average irradiances or photosynthetic photon flux densities measured in the following spectral bands: 280-315 nm (UVB); 315-380 nm (UVA); and 400-700 nm (photosynthetically active radiation, PAR); 510-700 nm; 600-700 nm; 610-680 nm; 690-780 nm; 400-1100 nm. A series of meteorological variables including relative air humidity and air temperature at surface is also provided at the same 10 min time step at all three stations, and precipitation is provided for two stations. Air pressure, wind speed, wind direction, and concentrations of air pollutants PM10, SO2, NOx, NO, NO2 were measured at the 1 h time step at the fourth station owned by the Public Health Institute of Ostrava. The details of the experimental sites and instruments used for the measurements are given. Special attention is given to the data quality, and the original approach to the data quality which was established is described in detail. About 130 000 records for each of the three stations are available in the database. This database offers a unique ensemble of variables having a high temporal resolution and it is a reliable source for radiation in relation to environment and vegetation in highly polluted areas of industrial cities in the of northern mid-latitudes. The database has been placed on the PANGAEA repository (https://doi.org/10.1594/PANGAEA.879722" target="_blank">https://doi.org/10.1594/PANGAEA.879722) and contains individual data files for each station.

  7. Western diet enhances intestinal tumorigenesis in Min/+ mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity.

    Science.gov (United States)

    Niku, Mikael; Pajari, Anne-Maria; Sarantaus, Laura; Päivärinta, Essi; Storvik, Markus; Heiman-Lindh, Anu; Suokas, Santeri; Nyström, Minna; Mutanen, Marja

    2017-01-01

    Western-type diet (WD) is a risk factor for colorectal cancer, but the underlying mechanisms are poorly understood. We investigated the interaction of WD and heterozygous mutation in the Apc gene on adenoma formation and metabolic and immunological changes in the histologically normal intestinal mucosa of Apc Min/+ (Min/+) mice. The diet used was high in saturated fat and low in calcium, vitamin D, fiber and folate. The number of adenomas was twofold higher in the WD mice compared to controls, but adenoma size, proliferation or apoptosis did not differ. The ratio of the Min to wild-type allele was higher in the WD mice, indicating accelerated loss of Apc heterozygosity (LOH). Densities of intraepithelial CD3ε + T lymphocytes and of mucosal FoxP3 + regulatory T cells were higher in the WD mice, implying inflammatory changes. Western blot analyses from the mucosa of the WD mice showed suppressed activation of the ERK and AKT pathways and a tendency for reduced activation of the mTOR pathway as measured in phosphoS6/S6 levels. The expression of pyruvate dehydrogenase kinase 4 was up-regulated in both mRNA and protein levels. Gene expression analyses showed changes in oxidation/reduction, fatty acid and monosaccharide metabolic pathways, tissue organization, cell fate and regulation of apoptosis. Together, our results suggest that the high-risk Western diet primes the intestine to tumorigenesis through synergistic effects in energy metabolism, inflammation and oxidative stress, which culminate in the acceleration of LOH of the Apc gene. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. Reciprocal influence of B cells and tumor macro and microenvironments in the ApcMin/+ model of colorectal cancer.

    Science.gov (United States)

    Mion, Francesca; Vetrano, Stefania; Tonon, Silvia; Valeri, Viviana; Piontini, Andrea; Burocchi, Alessia; Petti, Luciana; Frossi, Barbara; Gulino, Alessandro; Tripodo, Claudio; Colombo, Mario P; Pucillo, Carlo E

    2017-01-01

    One of the most fascinating aspects of the immune system is its dynamism, meant as the ability to change and readapt according to the organism needs. Following an insult, we assist to the spontaneous organization of different immune cells which cooperate, locally and at distance, to build up an appropriate response. Throughout tumor progression, adaptations within the systemic tumor environment, or macroenvironment, result in the promotion of tumor growth, tumor invasion and metastasis to distal organs, but also to dramatic changes in the activity and composition of the immune system. In this work, we show the changes of the B-cell arm of the immune system following tumor progression in the Apc Min/+ model of colorectal cancer. Tumor macroenvironment leads to an increased proportion of total and IL-10-competent B cells in draining LNs while activates a differentiation route that leads to the expansion of IgA + lymphocytes in the spleen and peritoneum. Importantly, serum IgA levels were significantly higher in Apc Min/+ than Wt mice. The peculiar involvement of IgA response in the adenomatous transformation had correlates in the gut-mucosal compartment where IgA-positive elements increased from normal mucosa to areas of low grade dysplasia while decreasing upon overt carcinomatous transformation. Altogether, our findings provide a snapshot of the tumor education of B lymphocytes in the Apc Min/+ model of colorectal cancer. Understanding how tumor macroenvironment affects the differentiation, function and distribution of B lymphocytes is pivotal to the generation of specific therapies, targeted to switching B cells to an anti-, rather than pro-, tumoral phenotype.

  9. Short-term pyrrolidine dithiocarbamate administration attenuates cachexia-induced alterations to muscle and liver in ApcMin/+ mice

    Science.gov (United States)

    VanderVeen, Brandon N.; Enos, Reilly T.; Murphy, E. Angela; Carson, James A.

    2016-01-01

    Cancer cachexia is a complex wasting condition characterized by chronic inflammation, disrupted energy metabolism, and severe muscle wasting. While evidence in pre-clinical cancer cachexia models have determined that different systemic inflammatory inhibitors can attenuate several characteristics of cachexia, there is a limited understanding of their effects after cachexia has developed, and whether short-term administration is sufficient to reverse cachexia-induced signaling in distinctive target tissues. Pyrrolidine dithiocarbamate (PDTC) is a thiol compound having anti-inflammatory and antioxidant properties which can inhibit STAT3 and nuclear factor κB (NF-κB) signaling in mice. This study examined the effect of short-term PDTC administration to ApcMin/+ mice on cachexia-induced disruption of skeletal muscle protein turnover and liver metabolic function. At 16 weeks of age ApcMin/+ mice initiating cachexia (7% BW loss) were administered PDTC (10mg/kg bw/d) for 2 weeks. Control ApcMin/+ mice continued to lose body weight during the treatment period, while mice receiving PDTC had no further body weight decrease. PDTC had no effect on either intestinal tumor burden or circulating IL-6. In muscle, PDTC rescued signaling disrupting protein turnover regulation. PDTC suppressed the cachexia induction of STAT3, increased mTORC1 signaling and protein synthesis, and suppressed the induction of Atrogin-1 protein expression. Related to cachectic liver metabolic function, PDTC treatment attenuated glycogen and lipid content depletion independent to the activation of STAT3 and mTORC1 signaling. Overall, these results demonstrate short-term PDTC treatment to cachectic mice attenuated cancer-induced disruptions to muscle and liver signaling, and these changes were independent to altered tumor burden and circulating IL-6. PMID:27449092

  10. Intermittent KoldBlue cryotherapy of 3x10 min changes mid-portion Achilles tendon microcirculation.

    Science.gov (United States)

    Knobloch, Karsten; Grasemann, Ruth; Spies, Marcus; Vogt, Peter M

    2007-06-01

    Neovascularisation and microcirculatory changes have been reported in Achilles tendinopathy. Cryotherapy and compression, as part of a rest, ice, compression and elevation regimen, are shown to decrease pain and improve function. However, the microcirculatory changes following a given dosage of cryotherapy on mid-portion Achilles tendon remain unclear. Prospective clinical cohort study, level of evidence 2. 30 people (12 males, 33 (SD 12) years, body mass index 25.6 (5.3) kg/m2) were included in the cohort. 3x10 min KoldBlue ankle-cooling bandages were applied and microcirculation of Achilles tendon mid-portion was real-time and continuously assessed using a laser-Doppler-spectrophotometry system (O2C, Germany). Superficial capillary blood flow was reduced from 42 to 6, 5 and 3 relative units (rU) in the first, second and third cryotherapy periods, respectively (-65%, p = 0.001), with no significant capillary hyperaemia. Deep capillary tendon blood flow was reduced from 180 to 82, 53 and 52 rU (-71%, p = 0.001) within 6-9 min of application without hyperaemia. Superficial tendon oxygen saturation dropped significantly from 43% to 26%, 18% and 11% (p = 0.001) after repetitive cryotherapy, with persisting increase of tendon oxygenation during rewarming (51%, 49% and 54%, p = 0.077) up to 27% of the baseline level. At 8 mm tendon depth, cryotherapy preserved local oxygenation. Relative postcapillary venous tendon filling pressures were favourably reduced from 41 (11) to 31, 28 and 26 rU (-36%, p = 0.001) superficially and from 56 (11) to 45, 46 and 48 rU (-18%, p = 0.001) in deep capillary blood flow during cryotherapy, facilitating capillary venous clearance. Intermittent cryotherapy of 3x10 min significantly decreases local Achilles tendon mid-portion capillary blood flow by 71%. Within 2 min of rewarming, tendon oxygen saturation is re-established following cryotherapy. Postcapillary venous filling pressures are reduced during cryotherapy, favouring capillary

  11. Intermittent KoldBlue cryotherapy of 3×10 min changes mid‐portion Achilles tendon microcirculation

    Science.gov (United States)

    Knobloch, Karsten; Grasemann, Ruth; Spies, Marcus; Vogt, Peter M

    2007-01-01

    Background Neovascularisation and microcirculatory changes have been reported in Achilles tendinopathy. Cryotherapy and compression, as part of a rest, ice, compression and elevation regimen, are shown to decrease pain and improve function. However, the microcirculatory changes following a given dosage of cryotherapy on mid‐portion Achilles tendon remain unclear. Study design Prospective clinical cohort study, level of evidence 2. Methods 30 people (12 males, 33 (SD 12) years, body mass index 25.6 (5.3) kg/m2) were included in the cohort. 3×10 min KoldBlue ankle‐cooling bandages were applied and microcirculation of Achilles tendon mid‐portion was real‐time and continuously assessed using a laser‐Doppler‐spectrophotometry system (O2C, Germany). Results Superficial capillary blood flow was reduced from 42 to 6, 5 and 3 relative units (rU) in the first, second and third cryotherapy periods, respectively (−65%, p = 0.001), with no significant capillary hyperaemia. Deep capillary tendon blood flow was reduced from 180 to 82, 53 and 52 rU (−71%, p = 0.001) within 6–9 min of application without hyperaemia. Superficial tendon oxygen saturation dropped significantly from 43% to 26%, 18% and 11% (p = 0.001) after repetitive cryotherapy, with persisting increase of tendon oxygenation during rewarming (51%, 49% and 54%, p = 0.077) up to 27% of the baseline level. At 8 mm tendon depth, cryotherapy preserved local oxygenation. Relative postcapillary venous tendon filling pressures were favourably reduced from 41 (11) to 31, 28 and 26 rU (−36%, p = 0.001) superficially and from 56 (11) to 45, 46 and 48 rU (−18%, p = 0.001) in deep capillary blood flow during cryotherapy, facilitating capillary venous clearance. Conclusion Intermittent cryotherapy of 3×10 min significantly decreases local Achilles tendon mid‐portion capillary blood flow by 71%. Within 2 min of rewarming, tendon oxygen saturation is re

  12. MinION Analysis and Reference Consortium: Phase 2 data release and analysis of R9.0 chemistry.

    Science.gov (United States)

    Jain, Miten; Tyson, John R; Loose, Matthew; Ip, Camilla L C; Eccles, David A; O'Grady, Justin; Malla, Sunir; Leggett, Richard M; Wallerman, Ola; Jansen, Hans J; Zalunin, Vadim; Birney, Ewan; Brown, Bonnie L; Snutch, Terrance P; Olsen, Hugh E

    2017-01-01

    Long-read sequencing is rapidly evolving and reshaping the suite of opportunities for genomic analysis. For the MinION in particular, as both the platform and chemistry develop, the user community requires reference data to set performance expectations and maximally exploit third-generation sequencing. We performed an analysis of MinION data derived from whole genome sequencing of Escherichia coli K-12 using the R9.0 chemistry, comparing the results with the older R7.3 chemistry. We computed the error-rate estimates for insertions, deletions, and mismatches in MinION reads. Run-time characteristics of the flow cell and run scripts for R9.0 were similar to those observed for R7.3 chemistry, but with an 8-fold increase in bases per second (from 30 bps in R7.3 and SQK-MAP005 library preparation, to 250 bps in R9.0) processed by individual nanopores, and less drop-off in yield over time. The 2-dimensional ("2D") N50 read length was unchanged from the prior chemistry. Using the proportion of alignable reads as a measure of base-call accuracy, 99.9% of "pass" template reads from 1-dimensional ("1D")  experiments were mappable and ~97% from 2D experiments. The median identity of reads was ~89% for 1D and ~94% for 2D experiments. The total error rate (miscall + insertion + deletion ) decreased for 2D "pass" reads from 9.1% in R7.3 to 7.5% in R9.0 and for template "pass" reads from 26.7% in R7.3 to 14.5% in R9.0. These Phase 2 MinION experiments serve as a baseline by providing estimates for read quality, throughput, and mappability. The datasets further enable the development of bioinformatic tools tailored to the new R9.0 chemistry and the design of novel biological applications for this technology. K: thousand, Kb: kilobase (one thousand base pairs), M: million, Mb: megabase (one million base pairs), Gb: gigabase (one billion base pairs).

  13. Cross-section measurement for the reaction 115In(n,n')/sup 115m/In

    International Nuclear Information System (INIS)

    Liskien, H.; Arnotte, F.; Widera, R.; Paulsen, A.

    1978-01-01

    The excitation function for the reaction 115 In(n,n')/sup 115m/In was measured by the activation technique from threshold up to 4.1 MeV in 0.1-MeV steps. The absolute normalization of this excitation junction was performed at 2.1 MeV and is based on n-p scattering. The total uncertainty of the results is typically +- 6% above 1 MeV. The results are in good agreement with recently published data. 2 figures, 3 tables

  14. Studies on derivatives of bat chelates labelled with 67Ca, 113mIn and 201Tl: Pt. 1

    International Nuclear Information System (INIS)

    Meng Min; Jin Yutai; Liu Boli; Zhu Lin

    1989-01-01

    The use of 3, 3, 10, 10-tetraethy 1-1, 2-dithio-5, 8-diazacyclodecane (BAT-TE) and 3, 3, 6, 6, 10, 10-hexamethyl-1, 2-dithio-5, 8-diazacy-clodecane (BAT-HM) as new ligands for the preparation of M-BAT-TE (M = Ca 3+ , In 3+ ) and M-BAT-HM (M = Ca 3+ , In 3+ , Tl 3+ ) were investigated. The chelating reactions with high labelling yield are fairly simple and rapid. The biodistribution of BAT derivative chelates in mice exhibited considerable myocardial uptake and good selectivity. Slow washout in heart and high heart-to-blood ratios were observed during the period from 2 min to 30 min after intravenous injection. Based on these experimental results, M-BAT-TE (M = Ca 3+ , In 3+ ) and M-BAT-HM (M = Ca 3+ , IN 3+ , Tl 3+ ) are considered as potential myocardial imaging agents, and particularly Tl-BAT-HM is likely a promising imaging agent

  15. Analyzing Sub-Threshold Bitcell Topologies and the Effects of Assist Methods on SRAM VMIN

    Directory of Open Access Journals (Sweden)

    James Boley

    2012-04-01

    Full Text Available The need for ultra low power circuits has forced circuit designers to scale voltage supplies into the sub-threshold region where energy per operation is minimized [1]. The problem with this is that the traditional 6T SRAM bitcell, used for data storage, becomes unreliable at voltages below about 700 mV due to process variations and decreased device drive strength [2]. In order to achieve reliable operation, new bitcell topologies and assist methods have been proposed. This paper provides a comparison of four different bitcell topologies using read and write VMIN as the metrics for evaluation. In addition, read and write assist methods were tested using the periphery voltage scaling techniques discussed in [4–13]. Measurements taken from a 180 nm test chip show read functionality (without assist methods down to 500 mV and write functionality down to 600 mV. Using assist methods can reduce both read and write VMIN by 100 mV over the unassisted test case.

  16. Geometric effect of the hydrogel grid structure on in vitro formation of homogeneous MIN6 cell clusters.

    Science.gov (United States)

    Bae, Chae Yun; Min, Mun-kyeong; Kim, Hail; Park, Je-Kyun

    2014-07-07

    A microstructure-based hydrogel was employed to study the relationship between spatial specificity and cellular behavior, including cell fate, proliferation, morphology, and insulin secretion in pancreatic β-cells. To effectively form homogeneous cell clusters in vitro, we made cell-containing hydrogel membrane constructs with an adapted grid structure based on a hexagonal micropattern. Homogeneous cell clusters (average diameter: 83.6 ± 14.2 μm) of pancreatic insulinoma (MIN6) cells were spontaneously generated in the floating hydrogel membrane constructs, including a hexagonal grid structure (size of cavity: 100 μm, interval between cavities: 30 μm). Interestingly, 3D clustering of MIN6 cells mimicking the structure of pancreatic islets was coalesced into a merged aggregate attaching to each hexagonal cavity of the hydrogel grid structure. The fate and insulin secretion of homogeneous cell clusters in the hydrogel grid structure were also assessed. The results of these designable hydrogel-cell membrane constructs suggest that facultative in vitro β-cell proliferation and maintenance can be applied to biofunctional assessments.

  17. MinION Nanopore Sequencing Enables Correlation between Resistome Phenotype and Genotype of Coliform Bacteria in Municipal Sewage

    Directory of Open Access Journals (Sweden)

    Yu Xia

    2017-10-01

    Full Text Available Wastewater treatment plants (WWTPs functioned as the intersection between the human society and nature environment, are receiving increasingly more attention on risk assessment of the acquisition of environmental antibiotic resistance genes (ARGs by pathogenetic populations during treatment. However, because of the general lack of robust resistome profiling methods, genotype, and resistance phenotype is still poorly correlated in human pathogens of sewage samples. Here we applied MinION sequencing to quantify the resistance genes of multiple antibiotic resistant (MAR coliform bacteria, a common indicator for human enteric pathogens in sewage samples. Our pipeline could deliver the results within 30 h from sample collection and the resistome quantification was consistent to that based on the Illumina platform. Additionally, the long nanopore reads not only enabled a simultaneous identification of the carrier populations of ARGs detected, but also facilitated the genome reconstruction of a representative MAR strain, from which we identified an instance of chromosomal integration of environmental resistance gene obtained by plasmid exchange with a porcine pathogen. This study demonstrated the utilization of MinION sequencing in quick monitoring and simultaneous phylogenetic tracking of environmental ARGs to address potential health risk associated with them.

  18. MinION Nanopore Sequencing Enables Correlation between Resistome Phenotype and Genotype of Coliform Bacteria in Municipal Sewage.

    Science.gov (United States)

    Xia, Yu; Li, An-Dong; Deng, Yu; Jiang, Xiao-Tao; Li, Li-Guan; Zhang, Tong

    2017-01-01

    Wastewater treatment plants (WWTPs) functioned as the intersection between the human society and nature environment, are receiving increasingly more attention on risk assessment of the acquisition of environmental antibiotic resistance genes (ARGs) by pathogenetic populations during treatment. However, because of the general lack of robust resistome profiling methods, genotype, and resistance phenotype is still poorly correlated in human pathogens of sewage samples. Here we applied MinION sequencing to quantify the resistance genes of multiple antibiotic resistant (MAR) coliform bacteria, a common indicator for human enteric pathogens in sewage samples. Our pipeline could deliver the results within 30 h from sample collection and the resistome quantification was consistent to that based on the Illumina platform. Additionally, the long nanopore reads not only enabled a simultaneous identification of the carrier populations of ARGs detected, but also facilitated the genome reconstruction of a representative MAR strain, from which we identified an instance of chromosomal integration of environmental resistance gene obtained by plasmid exchange with a porcine pathogen. This study demonstrated the utilization of MinION sequencing in quick monitoring and simultaneous phylogenetic tracking of environmental ARGs to address potential health risk associated with them.

  19. Determination of Glomerular Filtration Rate with {sup 51}Cr, {sup 58}Co, {sup 114m}In, {sup 115m}In and {sup 169}Yb- Labelled EDTA and DTPA Complexes

    Energy Technology Data Exchange (ETDEWEB)

    Molnar, Gy.; Pal, I.; Stuetzel, M.; Jaky, L. [Third Department of Medicine, University Medical School and Institute of Isotopes of the Hungarian Academy of Sciences, Budapest (Hungary)

    1971-02-15

    Some metal complexes are suitable for determination of the glomerular filtration rate (GFR). A series of labelled EDTA and DTPA complexes have been produced during the last two years by the Isotope Institute of the Hungarian Academy of Sciences. The common property of EDTA and DTPA complexes is their great stability, which is a major advantage over the iodinated compounds. We have demonstrated that none of the complexes used by us combine with plasma proteins or penetrate into the red blood cells. There is evidence that EDTA and DTPA leave the body exclusively by way of glomerular filtration. The results of more than 600 cases are presented. {sup 169}Yb EDTA was used in 315, {sup 51}Cr EDTA in 126, {sup 114m}In EDTA in 83, {sup 58}Co DTPA in 72 and {sup 115m}In EDTA in 28 cases for determination of GFR. The injected activity was 0.3 -4.0 {mu}Ci/kg body weight. In most cases the result has been compared with the 24-h endogenous creatine clearance, and in 50 cases with inulin clearance also. In general the single-shot method was used. Blood samples were taken about the first and the second hour after injection of the isotope. A formula is given for calculating GFR. In a few cases we administered the isotope in the same way as inulin (priming dose and constant plasma concentration sustained by an infusion pump). Our results show that the single-shot method is a very suitable one in routine clinical practice either in states of normal or reduced kidney function. Using the single-shot method for GFR determination is especially important in those cases where the collection of urine is impossible without using a catheter, which always entails the risk of infection. Results are reliable even in disorders of the urinary tract. During or after the procedure no side effects could be observed. (author)

  20. [Distribution Characteristics of Sedimentary Pigments in the Changjiang Estuary and Zhe-Min Coast and its Implications].

    Science.gov (United States)

    Li, Dong; Yao, Peng; Zhao, Bin; Wang, Jin-peng; Pan, Hui-hui

    2015-08-01

    Compositions and contents of sedimentary pigments were examined using high performance liquid chromatography in order to discuss the spatial distributions of phytoplankton primary production, phytoplankton functional type and the preservation efficiency of phytoplankton pigments and their influencing factors. The results showed that: chloropigments [Chlorins, including chlorophyll-a (Chl-a) and pheopigments (Pheo-a), such as pheophytin-a (PHtin-a), pheophorbide-a (PHide-a), pPheophytin-a (pPHtin-a), sterol chlorin esters (SCEs) and carotenol chlorin esters (CCEs)] were the major type of sedimentary pigments. The nutrients inputs from Changjiang Diluted Water and upwelling in the Zhe-Min coastal mud area were the major cause for the patchy distribution with high sedimentary chloropigment contents. Carotenoid contents showed no trending changes and exhibited high values in the Changjiang Estuary and Zhe-Min Coasts. Based on the relative proportions of each diagnostic carotenoid to the total diagnostic carotenoids in the sediments, the relative contributions of diatoms, dinoflagellates, prymnesiophytes, prasinophytes, cryptophytes and cyanobacterias in the phytoplankton fuctional types were 48.8% +/- 17.4%, 10.7% +/- 11.5%, 8.1% +/- 7.2%, 18.6% +/- 8.2%, 9.4% +/- 6.4% and 4.3% +/- 3.2%, respectively. The preference for external environmental conditions (e.g., nutrient level and water salinity) was the main cause for the decreasing trends of diatoms and dinoflagellates proportions and the increasing trends of prasinophytes, cryptophytes and cyanobacterias seawards. Based on the spatial distribution of Chl-a/Pheo-a ratios, the higher preservation efficiencies of sedimentary pigments in the coastal regions (e.g., outer edge of maximum turbidity zone in the Changjiang Estuary, mouth of the Hangzhou Bay and upwelling region in the Zhe-Min Coast) were mainly due to the higher sedimentation rate and seasonal occurrences of hypoxia in bottom water, and these regions with

  1. HUBUNGAN PENYAKIT GONDOK DENGAN KADAR YODIUM DALAM URIN MURID MADRASAH IBTIDAIYAH NEGERI (MIN KORONG GADANG KECAMATAN KURANJI KOTA PADANG

    Directory of Open Access Journals (Sweden)

    Yustini Alioes

    2010-09-01

    Full Text Available AbstrakYodium adalah komponen esensial dalam asupan makanan manusia, yang merupakan bagian dari hormone tiroid yaitu tiroksin (T4 and triiodotironin (T3. Hormon tersebut dibutuhkan untuk menjaga metabolism basal, metabolism sel, dan kesatuan jaringan tubuh. Hormone tiroid diperlukan dalam perkembangan system sarat janin dan bayi. Kekurangan asupan yodium dapat menyebabkan penyakit gondok, yaitu pembesaran kelenjar tiroid. Gondok endemic merupakan hasil dari peningkatan kerja kelenjar tiroid oleh Thyroid Stimulating Hormone (TSH dalam memaksimalkan penggunaan yodium yang tersedia, hal ini merupakan penyesuaian terhadap kekurangan yodium.Tujuan penelitian ini adalah untuk mengetahui hubungan penyakit gondok dengan kadar yodium dalam urin murid Madrasah Ibtidaiyah Negeri Korong Gadang Kecamatan Kuranji Kota Padang.Telah dilakukan penelitian pada 130 murid kelas II, III, IV, V dan VI di Madrasah Ibtidaiyah Negeri (MIN Korong Gadang Kecamatan Kuranji Kota Padang. Data tentang prestasi belajar didaptkan dari hasil ujian semester. Pertumbuhan fisik ditentukan berdasarkan berat badan dan tinggi badan.Selama penelitian ini didapatkan 80 anak (61,5% menderita penyakit gondok. Tidak didapatkan hubungan yang bermakna antara penyakit gondok dan kadar yodium dalam urin (p>0,05. Penelitian ini juga menemukan tidak terdapat hubungan antara penyakit gondok dan pertumbuhan fisik (p>0,05.Kata Kunci : Iodium, urin, hipertiroidAbstractIodine is an essential component of human diet, which part of thyroid hormones thyroxine (T4 and triiodothyronine (T3. These hormones are involved in the maintenance of metabolic rate, cellular metabolism and integrity of connective tissue. Thyroid hormones are necessary for the development of nervous system in the fetus and infant. Lack of dietary iodine is cause of goiter, an enlargement of the thyroid stimulating hormone (TSH to maximize the utilization of available iodine and thus respresents maladaption to iodine deficiency

  2. Multimodel inference applied to oxygen recovery kinetics after 6-min walk tests in patients with chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Baty, Florent; Ritz, Christian; Jensen, Signe Marie

    2017-01-01

    6-min walk tests (6MWT) are routinely performed in patients with chronic obstructive pulmonary disease (COPD). Oxygen uptake ([Formula: see text]) kinetics during 6MWT can be modeled and derived parameters provide indicators of patients' exercise capacity. Post-exercise [Formula: see text] recovery...... also provides important parameters of patients' fitness which has not been extensively investigated in COPD. Several nonlinear regression models with different underlying biological assumptions may be suitable for describing recovery kinetics. Multimodel inference (model averaging) can then be used...... to capture the uncertainty in considering several models. Our aim was to apply multimodel inference in order to better understand the physiological underpinnings of [Formula: see text] recovery after 6MWT in patients with COPD. 61 patients with COPD (stages 2 to 4) were included in this study. Oxygen...

  3. Quasi-min-max Fuzzy MPC of UTSG Water Level Based on Off-Line Invariant Set

    Science.gov (United States)

    Liu, Xiangjie; Jiang, Di; Lee, Kwang Y.

    2015-10-01

    In a nuclear power plant, the water level of the U-tube steam generator (UTSG) must be maintained within a safe range. Traditional control methods encounter difficulties due to the complexity, strong nonlinearity and “swell and shrink” effects, especially at low power levels. A properly designed robust model predictive control can well solve this problem. In this paper, a quasi-min-max fuzzy model predictive controller is developed for controlling the constrained UTSG system. While the online computational burden could be quite large for the real-time control, a bank of ellipsoid invariant sets together with the corresponding feedback control laws are obtained by off-line solving linear matrix inequalities (LMIs). Based on the UTSG states, the online optimization is simplified as a constrained optimization problem with a bisection search for the corresponding ellipsoid invariant set. Simulation results are given to show the effectiveness of the proposed controller.

  4. P-Q characteristic of the electromagnetic pump with the flow rate of 60 l/min

    International Nuclear Information System (INIS)

    Kim, Hee Reyoun; KIm, Jong Man; Cha, Jae Eun; Choi, Jong Hyun; Nam, Ho Yoon

    2005-01-01

    In general, an EM pump has been employed to circulate electrically conductive liquids like molten metals by Lorentz force generated from the magnetic field and its perpendicular current. Especially, at the Liquid Metal Reactor (LMR) which uses liquid sodium with high electrical conductivity as a coolant, an EM pump is noticed due to advantages over mechanical pump such as no rotating part, no noise and simplicity. In the present study, the EM pump of a pilot annular linear induction type with the flowrate of 60 l/min is designed by using electrical equivalent circuit method that is applied to linear induction machines. The designed pump is manufactured by consideration of the requirements of material and function in high temperature and sodium environments. Experimental characterization is carried out according to input currents and frequency. And compared analyses between theoretical prediction and experimental results are performed

  5. HUBUNGAN PENYAKIT GONDOK DENGAN PRESTASI BELAJAR DAN TINGGI BADAN ANAK MADRASAH IBTIDAIYAH NEGERI (MIN KORONG GADANG KECAMATAN KURANJI KOTA PADANG

    Directory of Open Access Journals (Sweden)

    Yusri Dianne Jurnalis

    2008-09-01

    Full Text Available AbstrakYodium adalah komponen esensial dalam asupan makanan manusia, yang merupakan bagian dari hormon tiroid yaitu tiroksin (T4 and triyodotironin (T3. Hormon tersebut dibutuhkan untuk menjaga metabolisme basal, metabolisme sel, dan kesatuan jaringan tubuh. Hormon tiroid diperlukan dalam pekembangan sistem saraf janin dan bayi. Kekurangan asupan yodium dapat menyebabkan penyakit gondok, yaitu pembesaran kelenjar tiroid. Gondok endemik merupakan hasil dari peningkatan kerja kelenjar tiroid oleh Thyroid Stimulating Hormone (TSH dalam memaksimalkan penggunaan yodium yang tersedia, hal ini merupakan penyesuaian terhadap keku-rangan yodium. Gangguan paling parah yang dapat disebabkan oleh kekurangan yodium adalah retardasi mental yang menetap dan hambatan pertumbuhan. Selama kurun wktu 5 tahun, prevalensi penyakit gondok di Kota Padang meningkat dari 8,5% menjadi 21,5%.Tujuan penelitian ini adalah untuk mengetahui prevalensi penyakit gondok dan hubungannya dengan prestasi belajar dan tinggi badan anak Madrasah Ibtidaiyah Negeri (MIN Korong Gadang Kecamatan Kuranji Kota Padang.Telah dilakukan penelitian pada 169 murid kelas II, III, IV, V, dan VI di Madrasah Ibtidaiyah Negeri (MIN Korong Gadang Kecamatan Kuranji Kota Padang. Data tentang prestasi belajar didapatkan dari hasil ujian semester. Tinggi badan ditentukan berdasarkan tinggi badan per umur.Selama penelitian ini didapatkan 84 anak (49,7% menderita penyakit gondok. Tidak didapatkan hubungan yang bermakna antara penyakit gondok dan prestasi belajar (p>0,05. Penelitian ini juga menemukan tidak terdapat hubungan antara penyakit gondok dan pertumbuhan fisik (p>0,05.Kata kunci : Penyakit Gondok, Prestasi Belajar, Tinggi Badan AnakAbstractIodine is an essential component of human diet, which part of thyroid hormones, thyroxine (T4 and triiodothyronine (T3. These hormones are involved in the maintenance of metabolic rate, cellular metabolism and integrity of connective tissue. Thyroid hormones are

  6. Applying the min-projection strategy to improve the transient performance of the three-phase grid-connected inverter.

    Science.gov (United States)

    Baygi, Mahdi Oloumi; Ghazi, Reza; Monfared, Mohammad

    2014-07-01

    Applying the min-projection strategy (MPS) to a three-phase grid-connected inverter to improve its transient performance is the main objective of this paper. For this purpose, the inverter is first modeled as a switched linear system. Then, the feasibility of the MPS technique is investigated and the stability criterion is derived. Hereafter, the fundamental equations of the MPS for the control of the inverter are obtained. The proposed scheme is simulated in PSCAD/EMTDC environment. The validity of the MPS approach is confirmed by comparing the obtained results with those of VOC method. The results demonstrate that the proposed method despite its simplicity provides an excellent transient performance, fully decoupled control of active and reactive powers, acceptable THD level and a reasonable switching frequency. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

  7. Phosphorylation events implicating p38 and PI3K mediate tungstate-effects in MIN6 beta cells

    International Nuclear Information System (INIS)

    Piquer, Sandra; Barcelo-Batllori, Silvia; Julia, Marta; Marzo, Nuria; Nadal, Belen; Guinovart, Joan J.; Gomis, Ramon

    2007-01-01

    Oral administration of sodium tungstate is an effective treatment for diabetes in animal models. Several lines of evidence indicate the pancreatic beta cell as one of the targets of tungstate action. Here, we examined the molecular mechanism by which this compound exerts its effects on the beta cell line MIN6. Tungstate treatment induced phosphorylation and subsequent activation of p38 and PI3K which in turn are implicated in tungstate PDX-1 nuclear localization and activation. Although no effect was observed in glucose-induced insulin secretion we found that tungstate activates basal insulin release, a process driven, at least in part, by activation of p38. These results show a direct involvement of p38 and PI3K phosphorylation in the mechanism of action of tungstate in the beta cell

  8. Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype

    International Nuclear Information System (INIS)

    Lentini, Laura; Amato, Angela; Schillaci, Tiziana; Di Leonardo, Aldo

    2007-01-01

    Genetic instability is a hallmark of tumours and preneoplastic lesions. The predominant form of genome instability in human cancer is chromosome instability (CIN). CIN is characterized by chromosomal aberrations, gains or losses of whole chromosomes (aneuploidy), and it is often associated with centrosome amplification. Centrosomes control cell division by forming a bipolar mitotic spindle and play an essential role in the maintenance of chromosomal stability. However, whether centrosome amplification could directly cause aneuploidy is not fully established. Also, alterations in genes required for mitotic progression could be involved in CIN. A major candidate is represented by Aurora-A/STK15 that associates with centrosomes and is overexpressed in several types of human tumour. Centrosome amplification were induced by hydroxyurea treatment and visualized by immunofluorescence microscopy. Aurora-A/STK15 ectopic expression was achieved by retroviral infection and puromycin selection in HCT116 tumour cells. Effects of Aurora-A/STK15 depletion on centrosome status and ploidy were determined by Aurora-A/STK15 transcriptional silencing by RNA interference. Changes in the expression levels of some mitotic genes were determined by Real time RT-PCR. We investigated whether amplification of centrosomes and overexpression of Aurora-A/STK15 induce CIN using as a model system a colon carcinoma cell line (HCT116). We found that in HCT116 cells, chromosomally stable and near diploid cells harbouring a MIN phenotype, centrosome amplification induced by hydroxyurea treatment is neither maintained nor induces aneuploidy. On the contrary, ectopic overexpression of Aurora-A/STK15 induced supernumerary centrosomes and aneuploidy. Aurora-A/STK15 transcriptional silencing by RNA interference in cells ectopically overexpressing this kinase promptly decreased cell numbers with supernumerary centrosomes and aneuploidy. Our results show that centrosome amplification alone is not sufficient

  9. The 1-min sit-to-stand test--A simple functional capacity test in cystic fibrosis?

    Science.gov (United States)

    Radtke, Thomas; Puhan, Milo A; Hebestreit, Helge; Kriemler, Susi

    2016-03-01

    We aimed to assess the measurement properties and the minimal important difference (MID) of the 1-min sit-to-stand (STS) test in cystic fibrosis (CF). Patients with CF were tested during a pulmonary rehabilitation program. Five STS tests were performed during the program; two tests at the beginning (STS0 and STS1) and three tests at the end (STS2a-2c). Exercise capacity, pulmonary function, and health-related quality of life (HRQoL) and patient-reported health status were measured at the beginning and end of the program. We calculated overall mean, standard deviation, coefficient of variation (CV), and intraclass correlation coefficient (ICC) of the STS test. The MID was calculated using anchor-based and distributional methods. Fourteen participants (8 female, mean age 30.4±6.1years) were included. STS test performance increased significantly from STS0 to STS1 indicative of a learning effect. Test-retest reliability for the subsequent STS2a-2c tests was excellent (ICC 0.98, 95% CI 0.96-0.99). The estimated MID for the STS test was 5 repetitions. STS test performance was responsive to change (effect size of 0.97) and correlated with exercise capacity (r=0.63-0.73) and with the physical functioning HRQoL scale (r=0.72). The 1-min STS test appears to be a reliable, valid, and feasible test to measure functional capacity in patients with CF. Copyright © 2015 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

  10. Effects of dietary beef, pork, chicken and salmon on intestinal carcinogenesis in A/J Min/+ mice.

    Directory of Open Access Journals (Sweden)

    Christina Steppeler

    Full Text Available The International Agency for Research on Cancer has classified red meat as "probably carcinogenic to humans" (Group 2A. In mechanistic studies exploring the link between intake of red meat and CRC, heme iron, the pigment of red meat, is proposed to play a central role as a catalyzer of luminal lipid peroxidation and cytotoxicity. In the present work, the novel A/J Min/+ mouse was used to investigate the effects of dietary beef, pork, chicken, or salmon (40% muscle food (dry weight and 60% powder diet on Apc-driven intestinal carcinogenesis, from week 3-13 of age. Muscle food diets did not differentially affect carcinogenesis in the colon (flat ACF and tumors. In the small intestine, salmon intake resulted in a lower tumor size and load than did meat from terrestrial animals (beef, pork or chicken, while no differences were observed between the effects of white meat (chicken and red meat (pork and beef. Additional results indicated that intestinal carcinogenesis was not related to dietary n-6 polyunsaturated fatty acids, intestinal formation of lipid peroxidation products (thiobarbituric acid reactive substances, TBARS, or cytotoxic effects of fecal water on Apc-/+ cells. Notably, the amount of heme reaching the colon appeared to be relatively low in this study. The greatest tumor load was induced by the reference diet RM1, underlining the importance of the basic diets in experimental CRC. The present study in A/J Min/+ mice does not support the hypothesis of a role of red meat in intestinal carcinogenesis.

  11. Nebulized salbutamol for asthma: Effects on serum potassium and phosphate levels at the 60 min

    Directory of Open Access Journals (Sweden)

    M. Sahan

    2013-09-01

    Full Text Available Objective: We conducted this prospective study to expand available information in relation to serum phosphate levels in treatment of acute asthma. A β-adrenergic agonist, salbutamol, was used for this purpose. Material and methods: Twenty-six patients who met the inclusion criteria as; age over 16 years, asthma history, and an acute exacerbation were included. Serum blood urea nitrogen, creatinine, glucose were within normal limits in all the patients. None of the patients were on chronic theophylline therapy. Baseline serum phosphate and potassium levels were measured. Nebulized salbutamol (2.5 mg was used three times at every hour. After 60 min, serum phosphate and potassium levels were measured. Results: Serum phosphate levels decreased from 3.7 ± 0.9 mg/dL (baseline to 3.6±0.9 mg/dL at 60 min. This decrease was not statistically significant (p = 0.373. Serum potassium levels decreased significantly (p < 0.001 from 4.6 ± 0.7 mmol/L (baseline to 4.3 ± 0.7 mmol/L (60 min. Conclusion: Administration of nebulized salbutamol during the emergency treatment of acute exacerbation of asthma is not associated with a statistical decrease in serum phosphate. There was significant hypokalemia. This study indicates that a further study is needed to elucidate the clinical significance of nebulized salbutamol on serum phosphate. Resumo: Objetivo: Levámos a cabo este estudo prospetivo para ampliar a informação disponível relativamente aos níveis de fosfato sérico no tratamento de asma aguda. Foi utilizado um agonista β-adrenérgico, salbutamol, para este efeito. Materiais e métodos: Foram incluídos 26 doentes que cumpriam os critérios de inclusão de: idade superior a 16 anos, história de asma, incluindo uma exacerbação aguda. A ureia do soro sanguíneo, creatinina e glucose estavam nos limites normais em todos os doentes. Nenhum dos doentes era

  12. Educação e arte na redução missioneira de San Ignacio Miní - Education and art in the mission of San Ignacio Miní

    Directory of Open Access Journals (Sweden)

    Graciela Ormezzano, Brasil

    2012-03-01

    Full Text Available Esta investigação trata da arte nos processos educativos introduzidos pelos je-suítas junto aos índios guaranis. Objetiva-se descrever o espaço e a produção artística da redução de San Ignacio Miní e interpretar os modos educacionais dos europeus e sua influência na população autóctone, entre 1611 e 1768.  Trata-se de uma pesquisa bibliográfica que utiliza também fontes primárias embasadas na documentação já publicada e fotografias. Optou-se por uma abordagem qualitativa, seguindo o método histórico-antropológico descritivo de um grupo populacional assentado numa determinada redução e discute-se as relações educacionais entre ambas as culturas. Nesse sentido, são apontadas as diferenças culturais e o que pode ser compreendido como suas possibilidades de mixagem.Palavras-chave: arte, educação, missões. EDUCATION AND ART IN THE MISSION OF SAN IGNACIO MINÍAbstractThis research is about art in Jesuitical educative process with guaranis indians in the missions. The objective is to describe the space and the artistic production in San Ignacio Miní and to interpret the educational ways of Europeans and their influence in autochthons, between 1611 and 1768. This is a bibliographic research that uses also published primary fountains and photographs. It’s a qualitative study that follows the historic-anthropologic method that describe a group of people living in a determinate mission and talks about educational relations between both cultures and possibilities of fusion.Key-words: art, education, missions. EDUCACIÓN Y ARTE EN LA REDUCCIÓN MISIONERA  DE SAN IGNACIO MINÍResumenEsta investigación trata del arte en los procesos educativos introducidos por los jesuitas entre los indios guaraníes. El estudio objetiva describir el espacio y la producción artística de la reducción de San Ignacio Miní e interpretar las modalidades educacionales de los europeos y su influencia en la población autóctona, entre 1611

  13. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Circulation, O2 Transport and Haematology”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Circulation, O2 Transport and Haematology”ABS 1. TRANSITIONAL CHANGES IN CEREBRAL BLOOD VOLUME OF TERM AND PRETERM INFANTS WITH AND WITHOUT RESPIRATORY SUPPORT AFTER BIRTH • B. Schwaberger, G. Pichler, A. Avian, C. Binder-Heschl, N. Baik, B. UrlesbergerABS 2. HEMATOLOGIC ABNORMALITIES IN THE FIRST 72 HOURS OF LIFE IN SMALL-FOR-GESTATIONAL-AGE PRETERM NEWBORNS • A. Matic, A. RistivojevicABS 3. THE ANTICOAGULANT ACTION OF ACTIVATED PROTEIN C IN VERY PRETERM INFANTS • E. Neary, N. McCallion, B. Kevane, K. Egan, M. Cotter, F. Ni AinleABS 4. SURVIVAL AFTER CARDIAC ARREST IN THE NEONATAL INTENSIVE CARE UNIT • E. Foglia, R. Langeveld, L. Heimall, A. Deveney, A. Ades, E. JensenABS 5. A PATENT DUCTUS ARTERIOSUS SEVERITY SCORE INCORPORATING MARKERS OF HAEMODYNAMIC SIGNIFICANCE AND LEFT VENTRICLE DIASTOLIC FUNCTION PREDICTS CHRONIC LUNG DISEASE • A.T. James, J.D. Corcoran, P. Dicker, O. Franklin, Y.N. Elsayed, J. Ting, A. Sehgal, A. Malikawi, A. Harabor, A.S. Soraisham, P.J. McNamaraABS 6. A STUDY TO VALIDATE THE DURATION OF ASSESSMENT OF BASELINE NIRS VALUES IN PRETERM BABIES WITH ECHOCARDIOGRAPHICALLY

  14. Lichens as possible agents of sandstone deterioration in Jesuitic ruins of San Ignacio Miní (Misiones Province, Argentina

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    Rosato, V. G.

    2010-09-01

    Full Text Available The ruins of San Ignacio Miní, in NE Argentina, Misiones Province, included by the UNESCO in the list of World Heritage in 1984, were built in the 18th century by the Guarani people under the supervision of the Jesuite Congregation. The ruins are located in a tropical weather zone, exposed to extreme conditions of heat and humidity affecting the rocks used in its construction. These rocks are identified as siliceous sandstones, mainly formed by rounded to subrounded clasts, with scarce angulose particles, containing 96% quartz. Weather characteristics encourage the growth of vascular plants as well as algae and mosses and other organisms that damage materials. Among these, there are 18 lichen species (belonging to 18 genera, 8 foliose, 3 fruticose and 7 crustose. The damaging action of these lichens has been observed through SEM observations and EDAX microanalysis of rock samples colonized by Caloplaca sp. and Buellia sp.

    Incluidas en la lista de Patrimonio Mundial por la UNESCO, las ruinas de San Ignacio Miní, en el NE de Argentina, provincia de Misiones, fueron construidas en el siglo XVIII por pobladores guaraníes supervisados por la Compañía de Jesús. Las ruinas se encuentran en una zona de clima tropical, expuestas a condiciones extremas de calor y humedad que alteran a las rocas empleadas en su construcción. Estas rocas se identifican como areniscas silíceas, formadas por clastos redondeados a sub-redondeados, con escasas partículas angulosas, con un contenido de 96,0% cuarzo. Las características del clima favorecen el desarrollo tanto de plantas vasculares como también de musgos, algas y otros organismos capaces de dañar a los materiales. Entre éstos se incluyen 18 especies de líquenes (pertenecientes a 18 géneros, 8 foliosos, 3 fruticosos y 7 crustosos. Las observaciones con SEM y los microanálisis EDE de muestras de roca colonizadas por Caloplaca sp. y Buellia sp sugieren que estos líquenes ejercen una acci

  15. Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype

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    Schillaci Tiziana

    2007-11-01

    Full Text Available Abstract Background Genetic instability is a hallmark of tumours and preneoplastic lesions. The predominant form of genome instability in human cancer is chromosome instability (CIN. CIN is characterized by chromosomal aberrations, gains or losses of whole chromosomes (aneuploidy, and it is often associated with centrosome amplification. Centrosomes control cell division by forming a bipolar mitotic spindle and play an essential role in the maintenance of chromosomal stability. However, whether centrosome amplification could directly cause aneuploidy is not fully established. Also, alterations in genes required for mitotic progression could be involved in CIN. A major candidate is represented by Aurora-A/STK15 that associates with centrosomes and is overexpressed in several types of human tumour. Methods Centrosome amplification were induced by hydroxyurea treatment and visualized by immunofluorescence microscopy. Aurora-A/STK15 ectopic expression was achieved by retroviral infection and puromycin selection in HCT116 tumour cells. Effects of Aurora-A/STK15 depletion on centrosome status and ploidy were determined by Aurora-A/STK15 transcriptional silencing by RNA interference. Changes in the expression levels of some mitotic genes were determined by Real time RT-PCR. Results We investigated whether amplification of centrosomes and overexpression of Aurora-A/STK15 induce CIN using as a model system a colon carcinoma cell line (HCT116. We found that in HCT116 cells, chromosomally stable and near diploid cells harbouring a MIN phenotype, centrosome amplification induced by hydroxyurea treatment is neither maintained nor induces aneuploidy. On the contrary, ectopic overexpression of Aurora-A/STK15 induced supernumerary centrosomes and aneuploidy. Aurora-A/STK15 transcriptional silencing by RNA interference in cells ectopically overexpressing this kinase promptly decreased cell numbers with supernumerary centrosomes and aneuploidy. Conclusion Our

  16. Letter to the editor: Electric field fluctuations (25-35 min in the midnight dip equatorial ionosphere

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    J. Hanumath Sastri

    2000-02-01

    Full Text Available Measurements with a HF Doppler sounder at Kodaikanal (10.2°N, 77.5°E, geomagnetic latitude 0.8°N showed conspicuous quasi-periodic fluctuations (period 25-35 min in F region vertical plasma drift, Vz in the interval 0047-0210 IST on the night of 23/24 December, 1991 (Ap = 14, Kp < 4-. The fluctuations in F region vertical drift are found to be coherent with variations in Bz (north-south component of interplanetary magnetic field (IMF, in geomagnetic H/X components at high-mid latitude locations both in the sunlit and dark hemispheres and near the dayside dip equator, suggestive of DP2 origin. But the polarity of the electric field fluctuations at the midnight dip equator (eastward is the same as the dayside equator inferred from magnetic variations, contrary to what is expected of equatorial DP2. The origin of the coherent occurrence of equatorial electric field fluctuations in the DP2 range of the same sign in the day and night hemispheres is unclear and merits further investigations.Key words: Ionosphere (electric fields and currents; equatorial ionosphere; ionosphere-magnetosphere interactions

  17. Accurate, rapid identification of dislocation lines in coherent diffractive imaging via a min-max optimization formulation

    Energy Technology Data Exchange (ETDEWEB)

    Ulvestad, A. [Materials Science Division, Argonne National Laboratory, Lemont, IL 60439, USA; Menickelly, M. [Mathematics and Computer Science Division, Argonne National Laboratory, Lemont, IL 60439, USA; Wild, S. M. [Mathematics and Computer Science Division, Argonne National Laboratory, Lemont, IL 60439, USA

    2018-01-01

    Defects such as dislocations impact materials properties and their response during external stimuli. Imaging these defects in their native operating conditions to establish the structure-function relationship and, ultimately, to improve performance via defect engineering has remained a considerable challenge for both electron-based and x-ray-based imaging techniques. While Bragg coherent x-ray diffractive imaging (BCDI) is successful in many cases, nuances in identifying the dislocations has left manual identification as the preferred method. Derivative-based methods are also used, but they can be inaccurate and are computationally inefficient. Here we demonstrate a derivative-free method that is both more accurate and more computationally efficient than either derivative-or human-based methods for identifying 3D dislocation lines in nanocrystal images produced by BCDI. We formulate the problem as a min-max optimization problem and show exceptional accuracy for experimental images. We demonstrate a 227x speedup for a typical experimental dataset with higher accuracy over current methods. We discuss the possibility of using this algorithm as part of a sparsity-based phase retrieval process. We also provide MATLAB code for use by other researchers.

  18. A Fuzzy Max–Min Decision Bi-Level Fuzzy Programming Model for Water Resources Optimization Allocation under Uncertainty

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    Chongfeng Ren

    2018-04-01

    Full Text Available Water competing conflict among water competing sectors from different levels should be taken under consideration during the optimization allocation of water resources. Furthermore, uncertainties are inevitable in the optimization allocation of water resources. In order to deal with the above problems, this study developed a fuzzy max–min decision bi-level fuzzy programming model. The developed model was then applied to a case study in Wuwei, Gansu Province, China. In this study, the net benefit and yield were regarded as the upper-level and lower-level objectives, respectively. Optimal water resource plans were obtained under different possibility levels of fuzzy parameters, which could deal with water competing conflict between the upper level and the lower level effectively. The obtained results are expected to make great contribution in helping local decision-makers to make decisions on dealing with the water competing conflict between the upper and lower level and the optimal use of water resources under uncertainty.

  19. Chronic Trichuris muris infection causes neoplastic change in the intestine and exacerbates tumour formation in APC min/+ mice.

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    Kelly S Hayes

    2017-06-01

    Full Text Available Incidences of infection-related cancers are on the rise in developing countries where the prevalence of intestinal nematode worm infections are also high. Trichuris muris (T. muris is a murine gut-dwelling nematode that is the direct model for human T. trichiura, one of the major soil-transmitted helminth infections of humans. In order to assess whether chronic infection with T. muris does indeed influence the development of cancer hallmarks, both wild type mice and colon cancer model (APC min/+ mice were infected with this parasite. Parasite infection in wild type mice led to the development of neoplastic change similar to that seen in mice that had been treated with the carcinogen azoxymethane. Additionally, both chronic and acute infection in the APCmin/+ mice led to an enhanced tumour development that was distinct to the site of infection suggesting systemic control. By blocking the parasite induced T regulatory response in these mice, the increase in the number of tumours following infection was abrogated. Thus T. muris infection alone causes an increase in gut pathologies that are known to be markers of cancer but also increases the incidence of tumour formation in a colon cancer model. The influence of parasitic worm infection on the development of cancer may therefore be significant.

  20. Walking four times weekly for at least 15 min is associated with longevity in a cohort of very elderly people.

    Science.gov (United States)

    Fortes, Cristina; Mastroeni, Simona; Sperati, Alessandra; Pacifici, Roberta; Zuccaro, PierGiorgio; Francesco, Forastiere; Agabiti, Nerina; Piras, Giovanna; Amleto, D'Amicis; Ebrahim, Shah

    2013-03-01

    This study investigated the role of walking outdoors on longevity, controlling for individual and other life-style factors as possible confounders. A 10-year cohort study was conducted with 152 self-caring and mobile, mean age 80 years, were enrolled in the study. Information on socio-demographic characteristics, clinical and biochemical data, diet, physical activity, smoking, depression status, cognitive status and anthropometrics measurements, were obtained for all participants. Cox proportional-hazards models were used to determine independent predictors of longevity. During the 10-years of follow-up, 96 (63%) died. Old age, chronic diseases, smoking, depression, CD4/CD8 ratio and coffee consumption were significantly predictors of mortality. Over-all survival was highest for subjects walking at open air for 4 times weekly for at least 15 min in comparison to subjects walking less than 4 times weekly (40% versus 22%). After adjusting for sex, age, education, chronic diseases, smoking, Body Mass Index and CD4/CD8 ratio, elderly people walking at open air for four times weekly had 40% decreased risk of mortality that individuals who walked less than four times weekly [relative risk (RR)=0.53; 95% confidence interval (CI)=0.32-0.88, p=0.01]. Findings suggest an independent and protective effect of walking on mortality and supports the encouragement of physical activity in advanced age for increasing longevity. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  1. A Count Model to Study the Correlates of 60 Min of Daily Physical Activity in Portuguese Children

    Science.gov (United States)

    Borges, Alessandra; Gomes, Thayse Natacha; Santos, Daniel; Pereira, Sara; dos Santos, Fernanda K.; Chaves, Raquel; Katzmarzyk, Peter T.; Maia, José

    2015-01-01

    This study aimed to present data on Portuguese children (aged 9–11 years) complying with moderate-to-vigorous physical activity (MVPA) guidelines, and to identify the importance of correlates from multiple domains associated with meeting the guidelines. Physical activity (PA) was objectively assessed by accelerometry throughout seven days on 777 children. A count model using Poisson regression was used to identify the best set of correlates that predicts the variability in meeting the guidelines. Only 3.1% of children met the recommended daily 60 min of MVPA for all seven days of the week. Further, the Cochrane–Armitage chi-square test indicated a linear and negative trend (p < 0.001) from none to all seven days of children complying with the guidelines. The count model explained 22% of the variance in meeting MVPA guidelines daily. Being a girl, having a higher BMI, belonging to families with higher income, sleeping more and taking greater time walking from home to a sporting venue significantly reduced the probability of meeting daily recommended MVPA across the seven days. Furthermore, compared to girls, increasing sleep time in boys increased their chances of compliance with the MVPA recommendations. These results reinforce the relevance of considering different covariates’ roles on PA compliance when designing efficient intervention strategies to promote healthy and active lifestyles in children. PMID:25730296

  2. EFFECT OF UPPER-LIMB AND THORACIC MUSCLE STRENGTH ON 6-MIN WALK DISTANCE IN COPD PATIENTS

    Directory of Open Access Journals (Sweden)

    D Varalakshmi

    2014-06-01

    Full Text Available Background: Chronic obstructive pulmonary disease (COPD is the only cause of death from chronic disease that will increase worldwide until 2020 and it represents a big burden for patients and society. Patients with COPD characteristically show poor exercise performance indicated by a marked reduction in both peak pulmonary 02 uptake and work rate at peak exercise. The sequelae of exercise intolerance include increased difficulty in performing daily tasks, etc. The objective of the study is to investigate the influence of thoracic and upper limb muscle function on 6-min walk distance (6MWD in patients with COPD. Method: Thirty eight COPD patients were included if they fulfilled the criteria for COPD according to the Global Initiative for Chronic Obstructive Lung Disease guidelines. Prospective, cross-sectional design with sample size of 38 patients. All patients performed 6MWD and 1RM exercises. Results: To study the correlation between variables, Pearson or Spearman coefficients of correlation were used with the level of statistical significance set at 5%.Results of this study suggested for the first time that thoracic muscle strength is a predictor of 6MWD in COPD patients. It also confirms the influence of respiratory muscle strength (Pimax, dyspnea, on the 6MWD of these patients. Conclusion: It is concluded that peripheral muscle strength, respiratory muscle strength, and the sensation of dyspnea all have an influence on the capacity of COPD patients to perform exercises.

  3. Polyyne-Enriched Extract from Oplopanax elatus Significantly Ameliorates the Progression of Colon Carcinogenesis in ApcMin/+ Mice

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    Xin Qiao

    2017-09-01

    Full Text Available Colorectal cancer (CRC is the third most common cancer in the world. Oplopanax elatus is widely used in traditional medicine. However, little is known about its pharmacological effects and bioactive compounds. We evaluated the effects of the polyyne-enriched extract from O. elatus (PEO on the progression of colon carcinogenesis in ApcMin/+ mice. In addition, these effects were also investigated in HCT116 and SW480 cells. After PEO oral administration (0.2% diet for 12 weeks, PEO significantly improved body weight changes and reduced the tumor burden and tumor multiplicity compared with the untreated mice. Meanwhile, western blot and immunohistochemistry results showed PEO significantly reduced the expression of β-catenin and cyclinD1 in both small intestine and the colon tissues compared with the untreated mice. In addition, PEO treatment significant decreased the cell viability in both HCT116 and SW480 cell lines. It also decreased the levels of β-catenin, cyclinD1, c-myc and p-GSK-3β in HCT116 and SW480 cells at 25 μM. These results indicate that PEO may have potential value in prevention of colon cancer by down-regulating Wnt-related protein.

  4. A Count Model to Study the Correlates of 60 Min of Daily Physical Activity in Portuguese Children

    Directory of Open Access Journals (Sweden)

    Alessandra Borges

    2015-02-01

    Full Text Available This study aimed to present data on Portuguese children (aged 9–11 years complying with moderate-to-vigorous physical activity (MVPA guidelines, and to identify the importance of correlates from multiple domains associated with meeting the guidelines. Physical activity (PA was objectively assessed by accelerometry throughout seven days on 777 children. A count model using Poisson regression was used to identify the best set of correlates that predicts the variability in meeting the guidelines. Only 3.1% of children met the recommended daily 60 min of MVPA for all seven days of the week. Further, the Cochrane–Armitage chi-square test indicated a linear and negative trend (p < 0.001 from none to all seven days of children complying with the guidelines. The count model explained 22% of the variance in meeting MVPA guidelines daily. Being a girl, having a higher BMI, belonging to families with higher income, sleeping more and taking greater time walking from home to a sporting venue significantly reduced the probability of meeting daily recommended MVPA across the seven days. Furthermore, compared to girls, increasing sleep time in boys increased their chances of compliance with the MVPA recommendations. These results reinforce the relevance of considering different covariates’ roles on PA compliance when designing efficient intervention strategies to promote healthy and active lifestyles in children.

  5. Molecular typing for blood group antigens within 40 min by direct polymerase chain reaction from plasma or serum.

    Science.gov (United States)

    Wagner, Franz F; Flegel, Willy A; Bittner, Rita; Döscher, Andrea

    2017-03-01

    Determining blood group antigens by serological methods may be unreliable in certain situations, such as in patients after chronic or massive transfusion. Red cell genotyping offers a complementary approach, but current methods may take much longer than conventional serological typing, limiting their utility in urgent situations. To narrow this gap, we devised a rapid method using direct polymerase chain reaction (PCR) amplification while avoiding the DNA extraction step. DNA was amplified by PCR directly from plasma or serum of blood donors followed by a melting curve analysis in a capillary rapid-cycle PCR assay. We evaluated the single nucleotide polymorphisms underlying the clinically relevant Fy a , Fy b , Jk a and Jk b antigens, with our analysis being completed within 40 min of receiving a plasma or serum sample. The positive predictive value was 100% and the negative predictive value at least 84%. Direct PCR with melting point analysis allowed faster red cell genotyping to predict blood group antigens than any previous molecular method. Our assay may be used as a screening tool with subsequent confirmatory testing, within the limitations of the false-negative rate. With fast turnaround times, the rapid-cycle PCR assay may eventually be developed and applied to red cell genotyping in the hospital setting. © 2016 John Wiley & Sons Ltd.

  6. Integración de Estándares de Gestión de TI mediante MIN-ITs

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    Antoni Lluís Mesquida

    2014-03-01

    Full Text Available Las empresas de desarrollo de software han apostado por la implantación de modelos y estándares de calidad con el objetivo de ofrecer productos que se adapten a las necesidades de los clientes y aumenten su satisfacción. Además de mejorar sus procesos de desarrollo de software, estas organizaciones también desean aumentar la capacidad de los procesos de otras disciplinas, como pueden ser la gestión de servicios de Tecnologías de la Información (TI o la gestión de la seguridad de la información. Las normas ISO que definen las mejoras prácticas de estas áreas guardan una gran cantidad de relaciones entre sus recomendaciones, directrices y requisitos. A partir del estudio de todos estos elementos y aspectos comunes, se ha desarrollado el marco MIN-ITs, un marco que facilita la implantación integrada de los diferentes estándares ISO de gestión de TI.

  7. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Neonatal Infectious Diseases/Immunology"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Neonatal Infectious Diseases/Immunology"ABS 1. UPTAKE OF PERTUSSIS AND INFLUENZA VACCINES IN PREGNANCY • A. Saso, B. Donaldson, B. KampmannABS 2. THE FREQUENCY OF MANNAN-BINDING LECTIN (MBL DEFICIENCY IN PREMATURE BABIES AND THE EFFECT ON LONG TERM MORBIDITIES • H. Ozkan, P.Dogan, N. Koksal, B. Oral, O. Bagcı, I. VaralABS 3. SEVERE COMBINED IMMUNE DEFICIENCY AND CONTINUED BREASTFEEDING: REPORT OF 5 OWN MOTHER’S MILK DONATION (OMM AT THE REGIONAL ILE DE FRANCE MILK BANK • V. Rigourd, D. Moshous, J.F. Méritet, M. Nicloux, C. Hovhannisyan, M. Dorsi, T. Hachem, P. Frange, A. Lapillonne, J.F. MagnyABS 4. MATERNAL CONTRIBUTION TO NEONATAL MICROBIOTA • R.S. Procianoy, L.F. Roesch, A.L. Corso, V. Mai, R.C. SilveiraABS 5. ANTIMICROBIAL ACTIVITY OF COPPER IN REDUCING ENVIRONMENTAL BURDEN IN A NEONATAL INTENSIVE CARE UNIT (NICU • Ch. Petropoulou, E. Kouskouni, P. Efstathiou, H. Bouza, Z. Manolidou, K. Karageorgou, A. Efstathiou, M. LogothetisABS 6. ANTIBIOTIC EXPOSURE IN NEONATES AND IMPACT ON GUT MICROBIOTA AND ANTIBIOTIC RESISTANCE DEVELOPMENT: A SYSTEMATIC REVIEW • J. Fjalstad, E

  8. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Quality Improvement, Parents Centered Care"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Quality Improvement, Parents Centered Care"ABS 1. REDUCING MEDICATION ERRORS IN NICU – A QUALITY IMPROVEMENT PROJECT • D.A. Al Masri, B. Ofoegbu, L. Yahya, K. Catroon, A. Saliba, H. IbrahimABS 2. PRETERM INFANTS WITH MEDICAL COM­PLEXITY: IMPACT ON HEALTH CARE RESOURCE USE, FAMILY EMPLOYMENT AND NEURODEVELOPMENTAL OUTCOMES • D. Nassel, C. Chartrand, M.-J. Doré-Bergeron, M. Ballantyne, F. Lefebvre, T.M. LuuABS 3. BREAST MILK DONATION IN THE MUSLIM POPULATION • S. Jebali, E. Ayachi, R. Terki Hassaine, A. Giuseppi, D. Vaiman, S. Brunet, V. RigourdABS 4. CORE OUTCOMES IN NEONATOLOGY: PRELIMINARY RESULTS • J. Webbe, N. Modi, C. Gale, on behalf of the COIN Steering GroupABS 5. A PILOT STUDY ASSESSING THE EFFECTIVENESS OF A FAMILY-CENTERED CARE INTERVENTION IN PRETERM INFANTS IN CHINA • R. Zhang, R. Huang, X. Gao, X. Peng, L. Zhu, R. Ramanathan, J. LatourABS 6. TO DETERMINE HOW MANY MOTHERS OF PRETERM BABIES, WHO WERE DELIVERED BETWEEN 24 AND 34 WEEKS GESTATION AND WERE ADMITTED TO NEONATAL UNIT AT ST. MARY’ S HOSPITAL, DID NOT RECEIVE ANTENATAL STEROIDS • A. Arunoday, A. Manou

  9. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Nutrition and gastroenterology”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Nutrition and gastroenterology”ABS 1. NEONATAL ANTIBIOTICS IN PRETERM INFANTS AND RISK OF ALLERGIC DISEASES LATER IN LIFE • E. Westerbeek, A. van Zwol, L. Carstens, R. van ElburgABS 2. FRENOTOMY FOR TONGUE-TIE IN NEWBORN INFANTS: A SYSTEMATIC REVIEW • J.E. O’Shea, J.P. Foster, S.E. Jacobs, C.P.F. O’Donnell, D.A. Todd, P.G. DavisABS 3. EARLY FORMULA MAY HELP SUPPORT LONG-TERM BREASTFEEDING • Z. Stranak, J. Kolarova, M. CernaABS 4. COMPARISON OF DRY BLOOD SPOT AMINO ACID PROFILES BETWEEN PRETERM INFANTS AT TERM POSTMENSTRUAL AGE AND HEALTHY TERM NEWBORNS • C. Balcells, M. Izquierdo-Renau, M. Molero, C. Sierra, R. Artuch, I. Iglesias-PlatasABS 5. VARIABILITY IN BONE MARKERS PROFILE OF NEWBORNS AND THEIR MOTHERS AFTER DHA SUPPLEMENTATION IN PREGNANCY • L. Serrano López, M. Peña Caballero, E. Martín Álvarez, J. Diaz Castro, N. Najarabille, J.J. Ochoa, J.A. Hurtado SuazoABS 6. A SYNBIOTIC MIXTURE OF scGOS/lcFOS AND BIFIDOBACTERIUM BREVE M-16V IS ABLE TO RESTORE THE DELAYED COLONIZATION OF BIFIDOBACTERIA SPP. IN C-SECTION DELIVERED INFANTS • M.C. Chua, C. Chew, A. Goh, W.C. Chiang, R. Rao1, C. Lay, K

  10. A single 60-min bout of peristaltic pulse external pneumatic compression transiently upregulates phosphorylated ribosomal protein s6.

    Science.gov (United States)

    Martin, J S; Kephart, W C; Mobley, C B; Wilson, T J; Goodlett, M D; Roberts, M D

    2017-11-01

    We investigated whether a single 60-min bout of whole leg, peristaltic pulse external pneumatic compression (EPC) altered select growth factor-related mRNAs and/or various phospho(p)-proteins related to cell growth, proliferation, inflammation and apoptosis signalling (e.g. Akt-mTOR, Jak-Stat). Ten participants (8 males, 2 females; aged 22·2 ± 0·4 years) reported to the laboratory 4 h post-prandial, and vastus lateralis muscle biopsies were obtained prior to (PRE), 1 h and 4 h post-EPC treatment. mRNA expression was analysed using real-time RT-PCR and phosphophorylated and cleaved proteins were analysed using an antibody array. No changes in selected growth factor-related mRNAs were observed following EPC. All p-proteins significantly altered by EPC decreased, except for p-rps6 (Ser235/236) which increased 31% 1 h post-EPC compared to PRE levels (P = 0·016). Notable decreases also included p-BAD (Ser112; -28%, P = 0·004) at 4 h post-EPC compared to PRE levels. In summary, an acute bout of EPC transiently upregulates p-rps6 as well as affecting other markers in the Akt-mTOR signalling cascade. Future research should characterize whether chronic EPC application promotes alterations in lower-limb musculature and/or enhances exercise-induced training adaptations. © 2016 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.

  11. Sub-1min separation in sequential injection chromatography for determination of synthetic water-soluble dyes in pharmaceutical formulation.

    Science.gov (United States)

    Davletbaeva, Polina; Chocholouš, Petr; Bulatov, Andrey; Šatínský, Dalibor; Solich, Petr

    2017-09-05

    Sequential Injection Chromatography (SIC) evolved from fast and automated non-separation Sequential Injection Analysis (SIA) into chromatographic separation method for multi-element analysis. However, the speed of the measurement (sample throughput) is due to chromatography significantly reduced. In this paper, a sub-1min separation using medium polar cyano monolithic column (5mm×4.6mm) resulted in fast and green separation with sample throughput comparable with non-separation flow methods The separation of three synthetic water-soluble dyes (sunset yellow FCF, carmoisine and green S) was in a gradient elution mode (0.02% ammonium acetate, pH 6.7 - water) with flow rate of 3.0mLmin -1 corresponding with sample throughput of 30h -1 . Spectrophotometric detection wavelengths were set to 480, 516 and 630nm and 10Hz data collection rate. The performance of the separation was described and discussed (peak capacities 3.48-7.67, peak symmetries 1.72-1.84 and resolutions 1.42-1.88). The method was represented by validation parameters: LODs of 0.15-0.35mgL -1 , LOQs of 0.50-1.25mgL -1 , calibration ranges 0.50-150.00mgL -1 (r>0.998) and repeatability at 10.0mgL -1 of RSD≤0.98% (n=6). The method was used for determination of the dyes in "forest berries" colored pharmaceutical cough-cold formulation. The sample matrix - pharmaceuticals and excipients were not interfering with vis determination because of no retention in the separation column and colorless nature. The results proved the concept of fast and green chromatography approach using very short medium polar monolithic column in SIC. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Max-Min SINR in Large-Scale Single-Cell MU-MIMO: Asymptotic Analysis and Low Complexity Transceivers

    KAUST Repository

    Sifaou, Houssem

    2016-12-28

    This work focuses on the downlink and uplink of large-scale single-cell MU-MIMO systems in which the base station (BS) endowed with M antennas communicates with K single-antenna user equipments (UEs). Particularly, we aim at reducing the complexity of the linear precoder and receiver that maximize the minimum signal-to-interference-plus-noise ratio subject to a given power constraint. To this end, we consider the asymptotic regime in which M and K grow large with a given ratio. Tools from random matrix theory (RMT) are then used to compute, in closed form, accurate approximations for the parameters of the optimal precoder and receiver, when imperfect channel state information (modeled by the generic Gauss-Markov formulation form) is available at the BS. The asymptotic analysis allows us to derive the asymptotically optimal linear precoder and receiver that are characterized by a lower complexity (due to the dependence on the large scale components of the channel) and, possibly, by a better resilience to imperfect channel state information. However, the implementation of both is still challenging as it requires fast inversions of large matrices in every coherence period. To overcome this issue, we apply the truncated polynomial expansion (TPE) technique to the precoding and receiving vector of each UE and make use of RMT to determine the optimal weighting coefficients on a per- UE basis that asymptotically solve the max-min SINR problem. Numerical results are used to validate the asymptotic analysis in the finite system regime and to show that the proposed TPE transceivers efficiently mimic the optimal ones, while requiring much lower computational complexity.

  13. Acute effects of static and dynamic stretching on jump performance after 15 min of reconditioning shooting phase in basketball players.

    Science.gov (United States)

    Annino, Giuseppe; Ruscello, Bruno; Lebone, Pietro; Palazzo, Francesco; Lombardo, Mauro; Padua, Elvira; Verdecchia, Luca; Tancredi, Virginia; Iellamo, Ferdinando

    2017-04-01

    The aim of this study was to assess the effects of static (SS) and dynamic stretching (DS) on vertical jump performance executed before, immediately after and at the end of the shooting phase (i.e., 15 min later), as to simulate the actual conditions preceding a match, in professional basketball players. Ten elite basketball players (age: 29±6.73 years, height: 194.67±7.75 cm, weight: 91±8.17 kg and BMI 23.8±7.91 kg.m-2) participated to the study. SS and DS protocols were administered during the first training session of the week, 48 hours after the championship match. Stretching protocols consisted in ~7 minutes of general warm-up phase followed by ~8 minutes of SS and DS, performed with a cross-over design., and ~15 minutes of a specific warm-up shooting phase (SP). Vertical jump tests consisted in counter movement jump (CMJ) and CMJ with arm swings (CMJas) and were performed immediately after the end of each stretching phase (preS, postS, postSP). A significant decrease (P=0.05; η2partial=0.29) in jumping tests height occurred in CMJas, when performed after the SS (i.e., PostS). However, no significant differences in jumping performances, occurred after the general warm phase and the specific warm-up shooting phase, between the two stretching protocols. These results would indicate that, overall, stretching routines either dynamic or static, performed before a basketball match are transient and affect only marginally leg muscles performance. Stretching routines, particularly the dynamic ones, may be useful to maintain muscle performance before a competition, provided that this latter begins shortly after.

  14. CH4MIN technology: a sustainable solution for the destruction of dilute methane emissions and the production of useful energy

    International Nuclear Information System (INIS)

    Sapoundjiev, H.

    2002-01-01

    Large quantities of methane are released into the atmosphere by underground coal mines. The coal industry worldwide is responsible for the emission of the equivalent of 460 million tons per year of carbon dioxide. Of that amount, approximately 250 million tons per year originate from coal mine ventilation air. A novel technology providing a sustainable energy solution to the conversion of these emissions into useful energy has been developed by the Canada Energy Technology Centre in Varennes, part of Natural Resources Canada. The technology has been called CH4MIN and is capable of converting the dilute methane contained in the emissions and produces useful energy in the form of heat or electricity. The technology couples the catalytic oxidation of the lean emissions in the reactor with regenerative heat exchange. Two beds of inert material are separated by the catalytic bed, and it acts as the regenerative heat exchanger, providing a very efficient heat transfer. Thermal stability and stable reactor operation are ensured by a periodic reversal in the direction of the flow of the mine ventilation air. Some of the heat from the reactor is used to produce electricity or heat for the mine. The preparation of a mathematical simulation of the expected process and an independent techno-economic feasibility study were performed during phase I of the development. New chemical reactor concepts, complex heat and mass transfer simulations were developed during phase II, as well as the development of a new two-dimensional model and algorithms, a novel design of a flow reversal reactor, the construction of unique large scale 500 millimeter diameter pilot scale reactor, the selection and testing of a catalyst with low pressure drop, high temperature resistance, poison resistance, and low cost. The preparation of the first industrial demonstration is being carried out as part of phase III. This phase includes the licensing of the technology to private industry along with obtaining

  15. Early static {sup 18}F-FET-PET scans have a higher accuracy for glioma grading than the standard 20-40 min scans

    Energy Technology Data Exchange (ETDEWEB)

    Albert, Nathalie L.; Winkelmann, Isabel; Wenter, Vera; Mille, Erik; Todica, Andrei; Brendel, Matthias; Bartenstein, Peter [Ludwig-Maximilians-University Munich, Department of Nuclear Medicine, Munich (Germany); Suchorska, Bogdana; Tonn, Joerg-Christian [Ludwig-Maximilians-University Munich, Department of Neurosurgery, Munich (Germany); Schmid-Tannwald, Christine [Ludwig-Maximilians-University Munich, Institute for Clinical Radiology, Munich (Germany); La Fougere, Christian [University of Tuebingen, Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, Tuebingen (Germany)

    2016-06-15

    Current guidelines for glioma imaging by positron emission tomography (PET) using the amino acid analogue O-(2-[{sup 18}F]fluoroethyl)-L-tyrosine ({sup 18}F-FET) recommend image acquisition from 20-40 min post injection (p.i.). The maximal tumour-to-background evaluation (TBR{sub max}) obtained in these summation images does not enable reliable differentiation between low and high grade glioma (LGG and HGG), which, however, can be achieved by dynamic {sup 18}F-FET-PET. We investigated the accuracy of tumour grading using TBR{sub max} values at different earlier time points after tracer injection. Three hundred and fourteen patients with histologically proven primary diagnosis of glioma (131 LGG, 183 HGG) who had undergone 40-min dynamic {sup 18}F-FET-PET scans were retrospectively evaluated. TBR{sub max} was assessed in the standard 20-40 min summation images, as well as in summation images from 0-10 min, 5-15 min, 5-20 min, and 15-30 min p.i., and kinetic analysis was performed. TBR{sub max} values and kinetic analysis were correlated with histological classification. ROC analyses were performed for each time frame and sensitivity, specificity, and accuracy were assessed. TBR{sub max} values in the earlier summation images were significantly better for tumour grading (P < 0.001) when compared to standard 20-40 min scans, with best results for the early 5-15 min scan. This was due to higher TBR{sub max} in the HGG (3.9 vs. 3.3; p < 0.001), while TBR{sub max} remained nearly stable in the LGG (2.2 vs. 2.1). Overall, accuracy increased from 70 % in the 20-40 min analysis to 77 % in the 5-15 min images, but did not reach the accuracy of dynamic analysis (80 %). Early TBR{sub max} assessment (5-15 min p.i.) is more accurate for the differentiation between LGG and HGG than the standard static scan (20-40 min p.i.) mainly caused by the characteristic high {sup 18}F-FET uptake of HGG in the initial phase. Therefore, when dynamic {sup 18}F-FET-PET cannot be performed

  16. Liposome-based polymer complex as a novel adjuvant: enhancement of specific antibody production and isotype switch

    Directory of Open Access Journals (Sweden)

    Chen CH

    2012-02-01

    Full Text Available Chia-Hung Chen1,*, Yu-Ling Lin1,*, Yen-Ku Liu1, Pei-Juin He2, Ching-Min Lin1, Yi-Han Chiu2, Chang-Jer Wu3, Tian-Lu Cheng4, Shih-Jen Liu5,6,**, Kuang-Wen Liao1,2,**1Institute of Molecular Medicine and Bioengineering, 2Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 3Department of Food Science, National Taiwan Ocean University, Keelung, 4Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, 5National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, 6Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, , *Chia-Hung Chen and Yu-Ling Lin contributed equally to this work**Kuang-Wen Liao and Shih-Jen Liu contributed equally to this workAbstract: The aim of vaccination is to induce appropriate immunity against pathogens. Antibody-mediated immunity is critical for protection against many virus diseases, although it is becoming more evident that coordinated, multifunctional immune responses lead to the most effective defense. Specific antibody (Ab isotypes are more efficient at protecting against pathogen invasion in different locations in the body. For example, compared to other Ab isotypes, immunoglobulin (Ig A provides more protection at mucosal areas. In this study, we developed a cationic lipopolymer (liposome-polyethylene glycol-polyethyleneimine complex [LPPC] adjuvant that strongly adsorbs antigens or immunomodulators onto its surface to enhance or switch immune responses. The results demonstrate that LPPC enhances uptake ability, surface marker expression, proinflammatory cytokine release, and antigen presentation in mouse phagocytes. In contrast to Freund's adjuvant, LPPC preferentially activates Th1-immunity against antigens in vivo. With lipopolysaccharides or CpG oligodeoxynucleotides, LPPC dramatically enhances the IgA or IgG2A proportion of total Ig, even in hosts that have developed

  17. Heart Rate and Oxygen Saturation Change Patterns During 6-min Walk Test in Subjects With Chronic Thromboembolic Pulmonary Hypertension.

    Science.gov (United States)

    Inagaki, Takeshi; Terada, Jiro; Yahaba, Misuzu; Kawata, Naoko; Jujo, Takayuki; Nagashima, Kengo; Sakao, Seiichiro; Tanabe, Nobuhiro; Tatsumi, Koichiro

    2017-12-26

    The 6-min walk test (6MWT) is commonly performed to assess functional status in patients with chronic thromboembolic pulmonary hypertension. However, changes in heart rate and oxygen saturation ( S pO 2 ) patterns during 6MWT in patients with chronic thromboembolic pulmonary hypertension remain unclear. Thirty-one subjects with chronic thromboembolic pulmonary hypertension were retrospectively evaluated to examine the relationships between the change in heart rate (Δheart rate), heart rate acceleration time, slope of heart rate acceleration, heart rate recovery during the first minute after 6MWT (HRR1), change in S pO 2 (Δ S pO 2 ), S pO 2 reduction time, and S pO 2 recovery time during 6MWT, and the severity of pulmonary hemodynamics assessed by right heart catheterization and echocardiography. Subjects with severe chronic thromboembolic pulmonary hypertension had significantly longer heart rate acceleration time (144.9 ± 63.9 s vs 96.0 ± 42.5 s, P = .033), lower Δheart rate (47.4 ± 16.9 vs 61.8 ± 13.6 beats, P = .02), and lower HRR1 (13.3 ± 9.0 beats vs 27.1 ± 9.2 beats, P pulmonary hypertension. Subjects with severe chronic thromboembolic pulmonary hypertension also had significantly longer S pO 2 reduction time (178.3 ± 70.3 s vs 134.3 ± 58.4 s, P = .03) and S pO 2 recovery time (107.6 ± 35.3 s vs 69.8 ± 32.7 s, P = .004) than did subjects with mild chronic thromboembolic pulmonary hypertension. Multivariate linear regression analysis showed only mean pulmonary arterial pressure independently was associated with heart rate acceleration time and slope of heart rate acceleration. Heart rate and S pO 2 change patterns during 6MWT is predominantly associated with pulmonary hemodynamics in subjects with chronic thromboembolic pulmonary hypertension. Evaluating heart rate and S pO 2 change patterns during 6MWT may serve a safe and convenient way to follow the change in pulmonary hemodynamics. Copyright © 2017 by Daedalus Enterprises.

  18. Validity and reliability of the 10-m walk test and the 6-min walk test in spinal cord injury patients.

    Science.gov (United States)

    Scivoletto, G; Tamburella, F; Laurenza, L; Foti, C; Ditunno, J F; Molinari, M

    2011-06-01

    The 10-m walk test (10MWT) and the 6-min walk test (6MWT) have been recommended for assessment of walking in spinal cord injury (SCI) patients. The study was designed on test-retest analysis of the 10MWT and 6MWT. The objective of this study was to assess validity/reliability of different methods of performing the tests. The study was set at an SCI unit of a rehabilitation hospital. A total of 37 patients; whose median age was 58.5 years (interquartile range 40-66, full range 19-77); median time since onset of SCI was 24 months (interquartile range 16.25-70.5, full range 6-109). Non-traumatic etiology in 20 out of 37 patients; level: 12C, 14T and 11L; American Spinal Injury Association Impairment Scale grade: 35D/2C. Assessment with the 10MWT (with or without dynamic start) and the 6MWT (short or long track) by two blinded raters to evaluate inter/intra-rater reliabilities. The 10MWT was performed in a median of 19 s (25th-75th interquartile range 13-28) with the dynamic start and of 18.4 s (25th-75th interquartile range 12.6-29.9) with the static start (P=0.092). The correlation between the results of the two methods was between 0.98 and 0.99. The inter- and intra-rater reliabilities were between 0.95 and 0.99 for both the methods. The 6MWT showed significant differences according to the track length: patients walked a median of 226.7 m (25th-75th interquartile range 123.2-319) on the longer track and of 187.6 m (25th-75th interquartile range 69.7-240.6) on the short one (P<0.001). The correlation between the results of the two methods was between 0.91 and 0.93. The inter- and intra-rater reliabilities were between 0.98 and 0.99. The 10MWT shows high inter/intra-rater reliability and shows comparable results with both dynamic and static start. The different testing conditions of the 6MWT (track/turns) results in significant differences that need standardization for use in future trials.

  19. A new multicompartmental reaction-diffusion modeling method links transient membrane attachment of E. coli MinE to E-ring formation.

    Science.gov (United States)

    Arjunan, Satya Nanda Vel; Tomita, Masaru

    2010-03-01

    Many important cellular processes are regulated by reaction-diffusion (RD) of molecules that takes place both in the cytoplasm and on the membrane. To model and analyze such multicompartmental processes, we developed a lattice-based Monte Carlo method, Spatiocyte that supports RD in volume and surface compartments at single molecule resolution. Stochasticity in RD and the excluded volume effect brought by intracellular molecular crowding, both of which can significantly affect RD and thus, cellular processes, are also supported. We verified the method by comparing simulation results of diffusion, irreversible and reversible reactions with the predicted analytical and best available numerical solutions. Moreover, to directly compare the localization patterns of molecules in fluorescence microscopy images with simulation, we devised a visualization method that mimics the microphotography process by showing the trajectory of simulated molecules averaged according to the camera exposure time. In the rod-shaped bacterium Escherichia coli, the division site is suppressed at the cell poles by periodic pole-to-pole oscillations of the Min proteins (MinC, MinD and MinE) arising from carefully orchestrated RD in both cytoplasm and membrane compartments. Using Spatiocyte we could model and reproduce the in vivo MinDE localization dynamics by accounting for the previously reported properties of MinE. Our results suggest that the MinE ring, which is essential in preventing polar septation, is largely composed of MinE that is transiently attached to the membrane independently after recruited by MinD. Overall, Spatiocyte allows simulation and visualization of complex spatial and reaction-diffusion mediated cellular processes in volumes and surfaces. As we showed, it can potentially provide mechanistic insights otherwise difficult to obtain experimentally. The online version of this article (doi:10.1007/s11693-009-9047-2) contains supplementary material, which is available to

  20. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Neonatal Fetal Nutrition and Metabolism"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Neonatal Fetal Nutrition and Metabolism"ABS 1. PREVALENCE OF BREASTFEEDING AT 6 MONTHS IN SICK NEONATES • S. Kositamongkol, K. MoungsuwanABS 2. ROLE OF BREAST MILK AND FECAL MICROBIAL CONTENT IN DEVELOPMENT OF BREAST MILK JAUNDICE • N. Koksal, O. Bagcı, H. Ozkan, I. Varal, P. DoganABS 3. VARIABILITY IN THE PROTEIN AND FAT CONTENT OF THE DONOR HUMAN MILK SUPPLY REVEALED BY MID-INFRARED SPECTROMETER ANALYSIS: A FIRST STEP TOWARDS PREVENTING DISRUPTION OF “PERINATAL PROGRAMMING” • V. Rigourd, Z. Assaf, A. Lapillonne, J.F. MagnyABS 4. BOVINE COLOSTRUM FOR PRETERM INFANTS IN THE FIRST DAYS OF LIFE: A RANDOMIZED CONTROLLED PILOT TRIAL • S.M. Juhl, X. Ye, P. Zhou, Y. Li, E.O. Iyore, L. Zhang, P. Jiang, J.B. van Goudoever, G. Greisen, P.T. SangildABS 5. PROTEIN AND CALORIC DEFICIT DURING THE NEONATAL PERIOD IN INFANTS WITH BIRTH WEIGHT LESS THAN 1,500 G AND ITS ASSOCIATION WITH BLOOD PRESSURE IN THE ADOLESCENCE • A. Dinerstein, C. Solana, R. Nieto, M. Casale, R. Conti, M. Moiron, F. GeneralABS 6. EFFECTS OF EXCLUSIVE DONOR HUMAN MILK FEEDING IN A SHORT PERIOD AFTER BIRTH ON

  1. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Neurology and Follow-up"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Neurology and Follow-up"ABS 1. PRETERM BIRTH AND THE TIMING OF PUBERTY • E. James, C. Wood, H. Nair, T. WilliamsABS 2. NEONATAL PAIN, OPIOID AND ANAESTHETIC EXPOSURE; WHAT REMAINS IN THE HUMAN BRAIN AFTER THE WHEELS OF TIME? • G.E. van den Bosch, D. Tibboel, J.C. de Graaff, H. El Marroun, A. van der Lugt, T. White, M. van DijkABS 3. DEPRESSION DURING PREGNANCY AND DNA METHYLATION CHANGES IN CORD BLOOD • A.-C. Viuff, G. Sharp, D. Raj, K.J. Kyng, L.H. Pedersen, T.B. Henriksen, C.L. ReltonABS 4. PREVENTION OF CEREBRAL PALSY: FEASIBILITY OF UMBILICAL CORD BLOOD STEM CELLS AND UMBILICAL CORD MESENCHYMAL STROMAL CELLS • H. Shintaku, M. Nabetani, T. Hamazaki, S. Kusuda, M. Tamura, S. Watabe, M. Hayakawa, Y. Sato, M. Tsuji, A. Taguchi, H. Ichiba, O. Akira, R. Mori, A.Taki, T. Mukai, T. Nagamura-InoueABS 5. NO GENDER-RELATED DIFFERENCES IN FETAL CORPUS CALLOSUM THICKNESS: IN-UTERO MRI STUDY • R. Bercovitz, R. Achiron, C. Hoffmann, A. AchironABS 6. NEUROMOTOR PROFILE OF HIGH-RISK INFANTS AT TERM OR NEAR TERM • I. Ereno, W.Y. TehABS 7. THE PREDICTIVE VALUE OF SEVERE BRONCHOPULMONARY

  2. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Neonatal Pulmonology, Neonatal Respiratory Support, Resuscitation"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Neonatal Pulmonology, Neonatal Respiratory Support, Resuscitation"ABS 1. HOW SAFE IS NASAL CANNULAE OXYGEN THERAPY DURING NEONATAL TRANSPORT? • A. Brunton, J. O’Shea, A. JacksonABS 2. WEANING PREMATURE INFANTS FROM NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE – CURRENT PRACTICE IN GERMANY • A. Kidszun, C. Arnold, J. Winter, C. Whybra-Trümpler, E. MildenbergerABS 3. TIMING OF KEY EVENTS IN NEONATAL RE­SUSCITATION • A. Heathcote, J. Jones, P. ClarkeABS 4. COMPARING NON-INVASIVE VENTILATION METHODS IN RESPIRATORY SUPPORT OF PRETERM NEONATES WITH RESPIRATORY DISEASES • A.S. Farhat, A. Mohammadzadeh, G.A. Mamuri, R. Saeidi, S. NoorizadehABS 5. PREDICTORS AND OUTCOMES OF CONTINU­OUS POSITIVE AIRWAY PRESSURE AND NA­SAL HIGH-FLOW TREATMENT FAILURE IN PRE­TERM INFANTS: A SECONDARY ANALYSIS OF A RANDOMIZED TRIAL • B. Manley, C. Roberts, D. Frøisland, L. Doyle, P. Davis, L. OwenABS 6. NEONATAL NON-INVASIVE RESPIRATORY SUPPORT APPROACH: A TWO COUNTRIES COMPARISON • I. Bresesti, S. Zivanovic, G. Lista, C. RoehrABS 7. PREDICTORS OF EARLY CPAP FAILURE IN VERY LOW BIRTH WEIGHT PRETERM

  3. CAIPIRINHA accelerated SPACE enables 10-min isotropic 3D TSE MRI of the ankle for optimized visualization of curved and oblique ligaments and tendons.

    Science.gov (United States)

    Kalia, Vivek; Fritz, Benjamin; Johnson, Rory; Gilson, Wesley D; Raithel, Esther; Fritz, Jan

    2017-09-01

    To test the hypothesis that a fourfold CAIPIRINHA accelerated, 10-min, high-resolution, isotropic 3D TSE MRI prototype protocol of the ankle derives equal or better quality than a 20-min 2D TSE standard protocol. Following internal review board approval and informed consent, 3-Tesla MRI of the ankle was obtained in 24 asymptomatic subjects including 10-min 3D CAIPIRINHA SPACE TSE prototype and 20-min 2D TSE standard protocols. Outcome variables included image quality and visibility of anatomical structures using 5-point Likert scales. Non-parametric statistical testing was used. P values ≤0.001 were considered significant. Edge sharpness, contrast resolution, uniformity, noise, fat suppression and magic angle effects were without statistical difference on 2D and 3D TSE images (p > 0.035). Fluid was mildly brighter on intermediate-weighted 2D images (p acceleration enables high-spatial resolution oblique and curved planar MRI of the ankle and visualization of ligaments, tendons and joints equally well or better than a more time-consuming anisotropic 2D TSE MRI. • High-resolution 3D TSE MRI improves visualization of ankle structures. • Limitations of current 3D TSE MRI include long scan times. • 3D CAIPIRINHA SPACE allows now a fourfold-accelerated data acquisition. • 3D CAIPIRINHA SPACE enables high-spatial-resolution ankle MRI within 10 min. • 10-min 3D CAIPIRINHA SPACE produces equal-or-better quality than 20-min 2D TSE.

  4. What’s in the pipeline? Drugs in development for autism spectrum disorder

    Directory of Open Access Journals (Sweden)

    Sung M

    2014-02-01

    Full Text Available Min Sung,1 Chee Hon Chin,1 Choon Guan Lim,1 Hwee Sen Alvin Liew,1 Chau Sian Lim,2 Espérance Kashala,1 Shih-Jen Weng1 1Department of Child and Adolescent Psychiatry, Institute of Mental Health, Singapore; 2Department of Psychological Medicine, Khoo Teck Puat Hospital, Singapore Abstract: Autism Spectrum Disorder (ASD is a complex neurodevelopmental disorder with both core symptoms and associated symptoms (eg, irritability, aggression, and comorbidities that affect both the individual and the family/systems around them. There have been recent advances in the understanding of the underlying pathophysiology of ASD pertaining to genetics, epigenetics, neurological, hormonal, and environmental factors that contribute to the difficulties found in individuals with ASD. With this improved understanding, there has been a shift in the application of psychopharmacology in ASD and its related disorders. A literature review was conducted to examine research published in the last 5 years between different classes of psychotropic medications and ASD. The broad scope of the existing literature for the use of conventional medications is summarized and novel medications are discussed. Keywords: pharmacology, treatment, autism, Asperger’s syndrome, medication

  5. Lack of anti-tumor activity with the β-catenin expression inhibitor EZN-3892 in the C57BL/6J Min/+ model of intestinal carcinogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Hasson, Rian M.; Briggs, Alexandra; Rizvi, Hira; Carothers, Adelaide M.; Davids, Jennifer S.; Bertagnolli, Monica M.; Cho, Nancy L., E-mail: nlcho@partners.org

    2014-02-14

    Highlights: • Wnt/β-catenin signaling is aberrantly activated in most colorectal cancers. • Locked nucleic acid (LNA)-based antisense is a novel tool for cancer therapy. • β-Catenin inhibition was observed in mature intestinal tissue of LNA-treated mice. • Further investigation of Wnt/β-catenin targeted therapies is warranted. - Abstract: Background: Previously, we showed that short-term inhibition of β-catenin expression and reversal of aberrant β-catenin subcellular localization by the selective COX-2 inhibitor celecoxib is associated with adenoma regression in the C57BL/6J Min/+ mouse. Conversly, long-term administration resulted in tumor resistance, leading us to investigate alternative methods for selective β-catenin chemoprevention. In this study, we hypothesized that disruption of β-catenin expression by EZN-3892, a selective locked nucleic acid (LNA)-based β-catenin inhibitor, would counteract the tumorigenic effect of Apc loss in Min/+ adenomas while preserving normal intestinal function. Materials and methods: C57BL/6J Apc{sup +/+} wild-type (WT) and Min/+ mice were treated with the maximum tolerated dose (MTD) of EZN-3892 (30 mg/kg). Drug effect on tumor numbers, β-catenin protein expression, and nuclear β-catenin localization were determined. Results: Although the tumor phenotype and β-catenin nuclear localization in Min/+ mice did not change following drug administration, we observed a decrease in β-catenin expression levels in the mature intestinal tissue of treated Min/+ and WT mice, providing proof of principle regarding successful delivery of the LNA-based antisense vehicle. Higher doses of EZN-3892 resulted in fatal outcomes in Min/+ mice, likely due to β-catenin ablation in the intestinal tissue and loss of function. Conclusions: Our data support the critical role of Wnt/β-catenin signaling in maintaining intestinal homeostasis and highlight the challenges of effective drug delivery to target disease without permanent

  6. A Comparison and Integration of MiSeq and MinION Platforms for Sequencing Single Source and Mixed Mitochondrial Genomes.

    Directory of Open Access Journals (Sweden)

    Michael R Lindberg

    Full Text Available Single source and multiple donor (mixed samples of human mitochondrial DNA were analyzed and compared using the MinION and the MiSeq platforms. A generalized variant detection strategy was employed to provide a cursory framework for evaluating the reliability and accuracy of mitochondrial sequences produced by the MinION. The feasibility of long-read phasing was investigated to establish its efficacy in quantitatively distinguishing and deconvolving individuals in a mixture. Finally, a proof-of-concept was demonstrated by integrating both platforms in a hybrid assembly that leverages solely mixture data to accurately reconstruct full mitochondrial genomes.

  7. 12 min/week of high-intensity interval training reduces aortic reservoir pressure in individuals with metabolic syndrome: a randomized trial.

    Science.gov (United States)

    Ramos, Joyce S; Dalleck, Lance C; Ramos, Maximiano V; Borrani, Fabio; Roberts, Llion; Gomersall, Sjaan; Beetham, Kassia S; Dias, Katrin A; Keating, Shelley E; Fassett, Robert G; Sharman, James E; Coombes, Jeff S

    2016-10-01

    Decreased aortic reservoir function leads to a rise in aortic reservoir pressure that is an independent predictor of cardiovascular events. Although there is evidence that high-intensity interval training (HIIT) would be useful to improve aortic reservoir pressure, the optimal dose of high-intensity exercise to improve aortic reservoir function has yet to be investigated. Therefore, this study compared the effect of different volumes of HIIT and moderate-intensity continuous training (MICT) on aortic reservoir pressure in participants with the metabolic syndrome (MetS). Fifty individuals with MetS were randomized into one of the following 16-week training programs: MICT [n = 17, 30 min at 60-70% peak heart rate (HRpeak), five times/week]; 4 × 4-min high-intensity interval training (4HIIT) (n = 15, 4 × 4 min bouts at 85-95% HRpeak, interspersed with 3 min of active recovery at 50-70% HRpeak, three times/week); and 1 × 4-min high-intensity interval training (1HIIT) (n = 18, 1 × 4 min bout at 85-95% HRpeak, three times/week). Aortic reservoir pressure was calculated from radial applanation tonometry. Although not statistically significant, there was a trend for a small-to-medium group × time interaction effect on aortic reservoir pressure, indicating a positive adaptation following 1HIIT compared with 4HIIT and MICT [F (2,46) = 2.9, P = 0.07, η = 0.06]. This is supported by our within-group analysis wherein only 1HIIT significantly decreased aortic reservoir pressure from pre to postintervention (pre-post: 1HIIT 33 ± 16 to 31 ± 13, P = 0.03; MICT 29 ± 9-28 ± 8, P = 0.78; 4HIIT 28 ± 10-30 ± 9 mmHg, P = 0.10). Three sessions of 4 min of high-intensity exercise per week (12 min/week) was sufficient to improve aortic reservoir pressure, and thus may be a time-efficient exercise modality for reducing cardiovascular risk in individuals with MetS.

  8. Evaluation of mosaic pattern areas in HRCT with Min-IP reconstructions in patients with pulmonary hypertension: Could this evaluation replace lung perfusion scintigraphy?

    International Nuclear Information System (INIS)

    Rossi, A.; Attinà, D.; Borgonovi, A.; Buia, F.; De Luca, F.; Guidalotti, P.L.; Fughelli, P.; Galiè, N.; Zompatori, M.

    2012-01-01

    Purpose: The aim of this study is to evaluate a possible correlation between areas of lung attenuation, found in minimum intensity projection (Min-IP) reconstruction images performed with high resolution computed tomography without contrast medium (HRCT), and areas of lung perfusion alteration, found in lung perfusion scintigraphy (LPS). Materials and methods: Two independent radiologists, unaware of LPS results, evaluated retrospectively a group of 113 patients affected by pulmonary hypertension (HP) of different aetiology. These have been examined in a period of two years in our centre both by spiral computed tomography (CT) with and without contrast-medium and by LPS. The final diagnosis was determined on clinical data, right heart catheterisation and contrast enhanced CT in angiographic phase (CTPA). We reconstructed the Min-IP images of lung parenchyma in all the cases both in HRCT without contrast-medium, and in contrast enhanced CT in angiographic phase (CTPA) in axial, sagittal and coronal planes. The obtained images were qualitatively graded into three categories of pulmonary attenuation: homogeneous, inhomogeneous with non-segmental patchy defects, inhomogeneous with segmental defects. The same criteria of classification were used also for LPS images. In the group of patients with chronic thromboembolic pulmonary hypertension (CTEPH) we also compared the number of areas of lung attenuation found in Min-IP images in HRCT without contrast-medium, and their exact localization, with not perfused areas in LPS. Gold standard for the diagnosis of pulmonary embolism was spiral contrast enhanced CT in angiographic phase (CTPA). Results: In all cases we found exact correspondence between the Min-IP images in HRCT with and without contras agent. The attenuation pattern seen on Min-IP images was concordant with those of LPS in 96 out of 113 patients (85%). In the remaining 17 cases (15%) it was discordant: in 12 cases inhomogeneous in Min-IP images (7 with non

  9. CAIPIRINHA accelerated SPACE enables 10-min isotropic 3D TSE MRI of the ankle for optimized visualization of curved and oblique ligaments and tendons

    Energy Technology Data Exchange (ETDEWEB)

    Kalia, Vivek [University of Vermont Medical Center, Department of Radiology, Burlington, VT (United States); Johns Hopkins University School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Section of Musculoskeletal Radiology, Baltimore, MD (United States); Fritz, Benjamin [University Medical Center Freiburg, Department of Radiology, Freiburg im Breisgau (Germany); Johnson, Rory [Siemens Healthcare USA, Inc, Cary, NC (United States); Gilson, Wesley D. [Siemens Healthcare USA, Inc, Baltimore, MD (United States); Raithel, Esther [Siemens Healthcare GmbH, Erlangen (Germany); Fritz, Jan [Johns Hopkins University School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Section of Musculoskeletal Radiology, Baltimore, MD (United States)

    2017-09-15

    To test the hypothesis that a fourfold CAIPIRINHA accelerated, 10-min, high-resolution, isotropic 3D TSE MRI prototype protocol of the ankle derives equal or better quality than a 20-min 2D TSE standard protocol. Following internal review board approval and informed consent, 3-Tesla MRI of the ankle was obtained in 24 asymptomatic subjects including 10-min 3D CAIPIRINHA SPACE TSE prototype and 20-min 2D TSE standard protocols. Outcome variables included image quality and visibility of anatomical structures using 5-point Likert scales. Non-parametric statistical testing was used. P values ≤0.001 were considered significant. Edge sharpness, contrast resolution, uniformity, noise, fat suppression and magic angle effects were without statistical difference on 2D and 3D TSE images (p > 0.035). Fluid was mildly brighter on intermediate-weighted 2D images (p < 0.001), whereas 3D images had substantially less partial volume, chemical shift and no pulsatile-flow artifacts (p < 0.001). Oblique and curved planar 3D images resulted in mildly-to-substantially improved visualization of joints, spring, bifurcate, syndesmotic, collateral and sinus tarsi ligaments, and tendons (p < 0.001, respectively). 3D TSE MRI with CAIPIRINHA acceleration enables high-spatial resolution oblique and curved planar MRI of the ankle and visualization of ligaments, tendons and joints equally well or better than a more time-consuming anisotropic 2D TSE MRI. (orig.)

  10. Serotonin- and Dopamine-Related Gene Expression in db/db Mice Islets and in MIN6 β-Cells Treated with Palmitate and Oleate

    Directory of Open Access Journals (Sweden)

    L. R. Cataldo

    2016-01-01

    Full Text Available High circulating nonesterified fatty acids (NEFAs concentration, often reported in diabetes, leads to impaired glucose-stimulated insulin secretion (GSIS through not yet well-defined mechanisms. Serotonin and dopamine might contribute to NEFA-dependent β-cell dysfunction, since extracellular signal of these monoamines decreases GSIS. Moreover, palmitate-treated β-cells may enhance the expression of the serotonin receptor Htr2c, affecting insulin secretion. Additionally, the expression of monoamine-oxidase type B (Maob seems to be lower in islets from humans and mice with diabetes compared to nondiabetic islets, which may lead to increased monoamine concentrations. We assessed the expression of serotonin- and dopamine-related genes in islets from db/db and wild-type (WT mice. In addition, the effect of palmitate and oleate on the expression of such genes, 5HT content, and GSIS in MIN6 β-cell was determined. Lower Maob expression was found in islets from db/db versus WT mice and in MIN6 β-cells in response to palmitate and oleate treatment compared to vehicle. Reduced 5HT content and impaired GSIS in response to palmitate (−25%; p<0.0001 and oleate (−43%; p<0.0001 were detected in MIN6 β-cells. In conclusion, known defects of GSIS in islets from db/db mice and MIN6 β-cells treated with NEFAs are accompanied by reduced Maob expression and reduced 5HT content.

  11. A 30-Min Nucleic Acid Amplification Point-of-Care Test for Genital Chlamydia trachomatis Infection in Women: A Prospective, Multi-center Study of Diagnostic Accuracy

    Directory of Open Access Journals (Sweden)

    E.M. Harding-Esch

    2018-02-01

    Conclusions: The io® CT-assay is a 30-min, fully automated, high-performing NAAT currently CE-marked for CT diagnosis in women, making it a highly promising diagnostic to enable specific treatment, initiation of partner notification and appropriately intensive health promotion at the point of care.

  12. Art as a Political Act: Expression of Cultural Identity, Self-Identity, and Gender by Suk Nam Yun and Yong Soon Min

    Science.gov (United States)

    Caruso, Hwa Young Choi

    2005-01-01

    This cross-cultural study explored the lives of two contemporary Korean/Korean American women artists--Suk Nam Yun and Yong Soon Min--who live in Seoul, South Korea, and Los Angeles, California. The author's research focused on the artists' identity formation, artistic expression, professional achievements, and the role of art as a political act.…

  13. Development and installation in cell of generators of 113Sn/sup(113m)In in the Argentine National Atomic Energy Commission

    International Nuclear Information System (INIS)

    Bianco de Salas, G.N.; Arciprete, J.A.; Mitta, A.E.A.

    1978-05-01

    The preparation of 113 Sn/sup(113m)In generators is described as well as its installation in cell. The chemical and radiochemical controls and the conditions to concentrate the eluate, if necessary, are described in detail. Production and exportation figures are given. (author) [es

  14. Quantitative study of the f-occupation in CeMIn{sub 5} and other cerium compounds with hard X-ray core level photo emission

    Energy Technology Data Exchange (ETDEWEB)

    Sundermann, Martin; Strigari, Fabio; Willers, Thomas; Severing, Andrea [University of Cologne, Cologne (Germany); Weinen, Jonas; Tjeng, Liu Hao [Max Planck Institute for Chemical Physics of Solids, Dresden (Germany); Liao, Yen-Fa; Tsuei, Ku-Ding [National Synchrotron Radiation Research Center, Hsinchu (China); Bauer, Eric D.; Sarrao, John L.; Thompson, Joe D. [Los Alamos National Laboratory, Los Alamos (United States); Lejay, Pascal [Institut NEEL, CNRS, Grenoble (France); Tanaka, Arata [Hiroshima University, Higashi-Hiroshima (Japan)

    2016-07-01

    Bulk-sensitive hard X-ray photoelectron spectroscopy (HAXPES) data of the Ce3d core levels of the CeMIn{sub 5} family with M = Co, Rh, and Ir will be presented. The data analysis combines a full multiplet and configuration interaction model so that the strong plasmons intensities can be corrected for. This way spectral f{sup n} weights can be extracted and the configuration interaction model yields quantitative values for the initial state f-occupation of the CeMIn{sub 5}. The results are compared with HAXPES data of other heavy Ce compounds of very different hybridization strength. A systematic decrease of the hybridization strength V{sub eff} from CePd{sub 3} to CeRh{sub 3}B{sub 2} to CeRu{sub 2}Si{sub 2} is observed, and it is smallest for the three CeMIn{sub 5} compounds. The f-occupation increases in the same sequence and is close to one for the CeMIn{sub 5} family.

  15. Analysis of Highly Nonlinear Oscillation System Using He's Max-Min Method and Comparison with Homotopy Analysis Method and Energy Balance Methods

    DEFF Research Database (Denmark)

    Ibsen, Lars Bo; Barari, Amin; Kimiaeifar, Amin

    2010-01-01

    of calculations. Results obtained by max–min are compared with Homotopy Analysis Method (HAM), energy balance and numerical solution and it is shown that, simply one term is enough to obtain a highly accurate result in contrast to HAM with just one term in series solution. Finally, the phase plane to show...... the stability of systems is plotted and discussed....

  16. Analysis of Highly Nonlinear Oscillation Systems Using He’s Max-Min Method and Comparison with Homotopy Analysis and Energy Balance Methods

    DEFF Research Database (Denmark)

    Ibsen, Lars Bo; Barari, Amin; Kimiaeifar, Amin

    2010-01-01

    of calculations. Results obtained by max–min are compared with Homotopy Analysis Method (HAM), energy balance and numerical solution and it is shown that, simply one term is enough to obtain a highly accurate result in contrast to HAM with just one term in series solution. Finally, the phase plane to show...... the stability of systems is plotted and discussed....

  17. Complicating Culture and Difference: Situating Asian American Youth Identities in Lisa Yee's "Millicent Min," "Girl Genius" and "Stanford Wong Flunks Big-Time"

    Science.gov (United States)

    Endo, Rachel

    2009-01-01

    This review situates how culture, difference, and identity are discursively constructed in "Millicent Min, Girl Genius" and "Stanford Wong Flunks Big-Time," two award-winning books written by critically acclaimed Asian American author Lisa Yee. Using contextual literacy approaches, the characters, cultural motifs, and physical settings in these…

  18. The 6-min mastication test: a unique test to assess endurance of continuous chewing, normal values, reliability, reproducibility and usability in patients with mitochondrial disease

    NARCIS (Netherlands)

    Engel-Hoek, L. van den; Knuijt, S.; Gerven, M.H.J.C van; Lagarde, M.L.J.; Groothuis, J.T.; Groot, I.J.M. de; Janssen, M.C.

    2017-01-01

    In patients with mitochondrial disease, fatigue and muscle problems are the most common complaints. They also experience these complaints during mastication. To measure endurance of continuous mastication in patients with mitochondrial diseases, the 6-min mastication test (6MMT) was developed. This

  19. CAIPIRINHA accelerated SPACE enables 10-min isotropic 3D TSE MRI of the ankle for optimized visualization of curved and oblique ligaments and tendons

    International Nuclear Information System (INIS)

    Kalia, Vivek; Fritz, Benjamin; Johnson, Rory; Gilson, Wesley D.; Raithel, Esther; Fritz, Jan

    2017-01-01

    To test the hypothesis that a fourfold CAIPIRINHA accelerated, 10-min, high-resolution, isotropic 3D TSE MRI prototype protocol of the ankle derives equal or better quality than a 20-min 2D TSE standard protocol. Following internal review board approval and informed consent, 3-Tesla MRI of the ankle was obtained in 24 asymptomatic subjects including 10-min 3D CAIPIRINHA SPACE TSE prototype and 20-min 2D TSE standard protocols. Outcome variables included image quality and visibility of anatomical structures using 5-point Likert scales. Non-parametric statistical testing was used. P values ≤0.001 were considered significant. Edge sharpness, contrast resolution, uniformity, noise, fat suppression and magic angle effects were without statistical difference on 2D and 3D TSE images (p > 0.035). Fluid was mildly brighter on intermediate-weighted 2D images (p < 0.001), whereas 3D images had substantially less partial volume, chemical shift and no pulsatile-flow artifacts (p < 0.001). Oblique and curved planar 3D images resulted in mildly-to-substantially improved visualization of joints, spring, bifurcate, syndesmotic, collateral and sinus tarsi ligaments, and tendons (p < 0.001, respectively). 3D TSE MRI with CAIPIRINHA acceleration enables high-spatial resolution oblique and curved planar MRI of the ankle and visualization of ligaments, tendons and joints equally well or better than a more time-consuming anisotropic 2D TSE MRI. (orig.)

  20. The golden 35 min of stroke intervention with ADAPT: effect of thrombectomy procedural time in acute ischemic stroke on outcome.

    Science.gov (United States)

    Alawieh, Ali; Pierce, Alyssa K; Vargas, Jan; Turk, Aquilla S; Turner, Raymond D; Chaudry, M Imran; Spiotta, Alejandro M

    2018-03-01

    In acute ischemic stroke (AIS), extending mechanical thrombectomy procedural times beyond 60 min has previously been associated with an increased complication rate and poorer outcomes. After improvements in thrombectomy methods, to reassess whether this relationship holds true with a more contemporary thrombectomy approach: a direct aspiration first pass technique (ADAPT). We retrospectively studied a database of patients with AIS who underwent ADAPT thrombectomy for large vessel occlusions. Patients were dichotomized into two groups: 'early recan', in which recanalization (recan) was achieved in ≤35 min, and 'late recan', in which procedures extended beyond 35 min. 197 patients (47.7% women, mean age 66.3 years) were identified. We determined that after 35 min, a poor outcome was more likely than a good (modified Rankin Scale (mRS) score 0-2) outcome. The baseline National Institutes of Health Stroke Scale (NIHSS) score was similar between 'early recan' (n=122) (14.7±6.9) and 'late recan' patients (n=75) (15.9±7.2). Among 'early recan' patients, recanalization was achieved in 17.8±8.8 min compared with 70±39.8 min in 'late recan' patients. The likelihood of achieving a good outcome was higher in the 'early recan' group (65.2%) than in the 'late recan' group (38.2%; p<0.001). Patients in the 'late recan' group had a higher likelihood of postprocedural hemorrhage, specifically parenchymal hematoma type 2, than those in the 'early recan' group. Logistic regression analysis showed that baseline NIHSS, recanalization time, and atrial fibrillation had a significant impact on 90-day outcomes. Our findings suggest that extending ADAPT thrombectomy procedure times beyond 35 min increases the likelihood of complications such as intracerebral hemorrhage while reducing the likelihood of a good outcome. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  1. The Miniature X-ray Solar Spectrometer (MinXSS) CubeSats: instrument capabilities and early science analysis on the quiet Sun, active regions, and flares.

    Science.gov (United States)

    Moore, Christopher S.; Woods, Tom; Caspi, Amir; Dennis, Brian R.; MinXSS Instrument Team, NIST-SURF Measurement Team

    2018-01-01

    Detection of soft X-rays (sxr) from the Sun provide direct information on coronal plasma at temperatures in excess of ~1 MK, but there have been relatively few solar spectrally resolved measurements from 0.5 – 10. keV. The Miniature X-ray Solar Spectrometer (MinXSS) CubeSat is the first solar science oriented CubeSat mission flown for the NASA Science Mission Directorate, and has provided measurements from 0.8 -12 keV, with resolving power ~40 at 5.9 keV, at a nominal ~10 second time cadence. MinXSS design and development has involved over 40 graduate students supervised by professors and professionals at the University of Colorado at Boulder. Instrument radiometric calibration was performed at the National Institute for Standard and Technology (NIST) Synchrotron Ultraviolet Radiation Facility (SURF) and spectral resolution determined from radioactive X-ray sources. The MinXSS spectra allow for determining coronal abundance variations for Fe, Mg, Ni, Ca, Si, S, and Ar in active regions and during flares. Measurements from the first of the twin CubeSats, MinXSS-1, have proven to be consistent with the Geostationary Operational Environmental Satellite (GOES) 0.1 – 0.8 nm energy flux. Simultaneous MinXSS-1 and Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) observations have provided the most complete sxr spectral coverage of flares in recent years. These combined measurements are vital in estimating the heating flare loops by non-thermal accelerated electrons. MinXSS-1 measurements have been combined with the Hinode X-ray Telescope (XRT) and Solar Dynamics Observatory Atmospheric Imaging Assembly (SDO-AIA) to further constrain the coronal temperature distribution during quiescent times. The structure of the temperature distribution (especially for T > 5 MK) is important for deducing heating processes in the solar atmosphere. MinXSS-1 observations yield some of the tightest constraints on the high temperature component of the coronal plasma, in the

  2. A Gridded Daily Min/Max Temperature Dataset With 0.1° Resolution for the Yangtze River Valley and its Error Estimation

    Science.gov (United States)

    Xiong, Qiufen; Hu, Jianglin

    2013-05-01

    The minimum/maximum (Min/Max) temperature in the Yangtze River valley is decomposed into the climatic mean and anomaly component. A spatial interpolation is developed which combines the 3D thin-plate spline scheme for climatological mean and the 2D Barnes scheme for the anomaly component to create a daily Min/Max temperature dataset. The climatic mean field is obtained by the 3D thin-plate spline scheme because the relationship between the decreases in Min/Max temperature with elevation is robust and reliable on a long time-scale. The characteristics of the anomaly field tend to be related to elevation variation weakly, and the anomaly component is adequately analyzed by the 2D Barnes procedure, which is computationally efficient and readily tunable. With this hybridized interpolation method, a daily Min/Max temperature dataset that covers the domain from 99°E to 123°E and from 24°N to 36°N with 0.1° longitudinal and latitudinal resolution is obtained by utilizing daily Min/Max temperature data from three kinds of station observations, which are national reference climatological stations, the basic meteorological observing stations and the ordinary meteorological observing stations in 15 provinces and municipalities in the Yangtze River valley from 1971 to 2005. The error estimation of the gridded dataset is assessed by examining cross-validation statistics. The results show that the statistics of daily Min/Max temperature interpolation not only have high correlation coefficient (0.99) and interpolation efficiency (0.98), but also the mean bias error is 0.00 °C. For the maximum temperature, the root mean square error is 1.1 °C and the mean absolute error is 0.85 °C. For the minimum temperature, the root mean square error is 0.89 °C and the mean absolute error is 0.67 °C. Thus, the new dataset provides the distribution of Min/Max temperature over the Yangtze River valley with realistic, successive gridded data with 0.1° × 0.1° spatial resolution and

  3. Abnormal glomerular filtration rate in children, adolescents and young adults starts below 75 mL/min/1.73 m(2).

    Science.gov (United States)

    Pottel, Hans; Hoste, Liesbeth; Delanaye, Pierre

    2015-05-01

    The chronic kidney disease (CKD) classification system for children is similar to that for adults, with both mainly based on estimated glomerular filtration rate (eGFR) combined with fixed cut-off values. The main cut-off eGFR value used to define CKD is 60 mL/min/1.73 m(2), a value that is also applied for children older than 2 years of age, adolescents and young adults. Based on a literature search, we evaluated inclusion criteria for eGFR in clinical trials or research studies on CKD for children. We also collected information on direct measurements of GFR (mGFR) in children and adolescents, with the aim to estimate the normal reference range for GFR. Using serum creatinine (Scr) normal reference values and Scr-based eGFR-equations, we also evaluated the correspondence between Scr normal reference values and (e)GFR normal reference values. Based on our literature search, the inclusion of children in published CKD studies has been based on cut-off values for eGFR of >60 mL/min/1.73 m(2). The lower reference limits for mGFR far exceed this adult threshold. Using eGFR values calculated using Scr-based formulas, we found that abnormal Scr levels in children already correspond to eGFR values that are below a cut-off of 75 mL/min/1.73 m(2). Abnormal GFR in children, adolescents and young adults starts below 75 mL/min/1.73 m(2), and as abnormality is a sign of disease, we recommend referring children, adolescents and young adults with an (e)GFR of <75 mL/min/1.73 m(2) for further clinical assessment.

  4. M.I.N. MATEE -.

    African Journals Online (AJOL)

    Furthermore, there' is a need of. developiItg a test which will require a smaller volume of saliva ,than the . one mL which is currently required. This improvement would reduce the specimen collection time in individuals with xerostomia due to organic illnesses or apprehension, mentally bandicapped and infants. R eprod u.

  5. Robotten, min best friend forever

    DEFF Research Database (Denmark)

    Bødker, Mads

    2016-01-01

    Er din næste kammesjuk en computer? Om et par år er det ikke svært at forestille sig en virkelighed, hvor vi kan tale med vores computer, som var det en person. Udviklingen peger allerede i den retning, men som det ser ud nu, er vores digitale venner bare lidt for rigide og tørre. Hvad skal der til...

  6. Development, preparation and control of sup(99m)Tc or sup(113m)In labelled stannous hydroxide radiopharmaceuticals. Part of a coordinated programme on radiopharmaceuticals

    International Nuclear Information System (INIS)

    Alvarez Cervera, J.

    1975-01-01

    The preparation of different sup(99m)Tc and sup(113m)In radiopharmaceuticals using stannous chloride was investigated. Chemical and radiochemical procedures for the quality control of these preparations were studied. Toxicity and biological controls of the preparation were carried out. Procedures for the preparation and control of the following radiopharmaceuticals have been standardized by the authors; albumin macroaggregates labelled with sup(99m)Tc, sup(113m)In and other isotopes for lung scanning; albumin microspheres labelled with sup(99m)Tc for lung scanning; sup(99m)Tc or sup(113m)In-labelled stannous hydroxide colloid for liver scanning; sup(99m)Tc-stannous phytate for liver scanning; sup(99m)Tc-Sn-dextrose, a new radiopharmaceutical which has been proposed by the authors and is now used in Mexico for renal and cerebral scanning and sup(99m)Tc-Sn pyrophosphate and diphosphonate for bone scanning

  7. Preparation of Radio-pharmaceuticals-III: An evaluation of the eluate from a {sup 113}Sn-{sup 113m}In cow system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, You Sun; Kim, Tae Young [Korea Atomic Research Institue, Seoul (Korea, Republic of)

    1969-03-15

    In 1968 total 94,660 mc of radioactive iodocompound were prepared and distributed to the urers. In order to obtain an effective liver scanning {sup 113m}Incolloidal of even partical size from a {sup 113}Sn-{sup 113m}In cow, the eluate(pH; 1.5) was examined by a radio paper partition chromatography. It was found that the eluate was composed of two components, ionic from and colloidal form. The ionid from could be eliminated by cation exchange resine and the eluate from the ion exchange resine was of even particle size to give an excellent liver scanning results. Labelling of {sup 113m}In to human serum albumine was attempted.

  8. The 6-min mastication test: a unique test to assess endurance of continuous chewing, normal values, reliability, reproducibility and usability in patients with mitochondrial disease.

    Science.gov (United States)

    van den Engel-Hoek, L; Knuijt, S; van Gerven, M H J C; Lagarde, M L J; Groothuis, J T; de Groot, I J M; Janssen, M C H

    2017-03-01

    In patients with mitochondrial disease, fatigue and muscle problems are the most common complaints. They also experience these complaints during mastication. To measure endurance of continuous mastication in patients with mitochondrial diseases, the 6-min mastication test (6MMT) was developed. This study included the collection of normal data for the 6MMT in a healthy population (children and adults). During 6 min of continuous mastication on a chew tube chewing cycles per minute, total amount of chewing cycles and the difference between minute 1 (M 1 ) and minute 6 (M 2 ) were collected in 271 healthy participants (5-80 years old). These results were compared with those of nine paediatric and 25 adult patients with a mitochondrial disease. Visual analogue scale (VAS) scores were collected directly after the test and after 5 min. A qualitative rating was made on masticatory movements. The reproducibility of the 6MMT in the healthy population with an interval of approximately 2 weeks was good. The inter-rater reliability for the observations was excellent. The patient group demonstrated lower total amount of chewing cycles or had greater differences between M 1 and M 6 . The 6MMT is a reliable and objective test to assess endurance of continuous chewing. It demonstrates the ability of healthy children and adults to chew during 6 min with a highly stable frequency of mastication movements. The test may give an explanation for the masticatory problems in patient groups, who are complaining of pain and fatigue during mastication. © 2017 John Wiley & Sons Ltd.

  9. Effects of Kapton Sample Cell Windows on the Detection Limit of Smectite: Implications for CheMin on the Mars Science Laboratory Mission

    Science.gov (United States)

    Achilles, C. N.; Ming, Douglas W.; Morris, R. V.; Blake, D. F.

    2012-01-01

    The CheMin instrument on the Mars Science Laboratory (MSL) rover Curiosity is an X-ray diffraction (XRD) and X-ray fluorescence (XRF) instrument capable of providing the mineralogical and chemical compositions of rocks and soils on the surface of Mars. CheMin uses a microfocus X-ray tube with a Co target, transmission geometry, and an energy-discriminating X-ray sensitive CCD to produce simultaneous 2-D XRD patterns and energy-dispersive X-ray histograms from powdered samples. CheMin has two different window materials used for sample cells -- Mylar and Kapton. Instrument details are provided elsewhere. Fe/Mg-smectite (e.g., nontronite) has been identified in Gale Crater, the MSL future landing site, by CRISM spectra. While large quantities of phyllosilicate minerals will be easily detected by CheMin, it is important to establish detection limits of such phases to understand capabilities and limitations of the instrument. A previous study indicated that the (001) peak of smectite at 15 Ang was detectable in a mixture of 1 wt.% smectite with olivine when Mylar is the window material for the sample cell. Complications arise when Kapton is the window material because Kapton itself also has a diffraction peak near 15 Ang (6.8 deg 2 Theta). This study presents results of mineral mixtures of smectite and olivine to determine smectite detection limits for Kapton sample cells. Because the intensity and position of the smectite (001) peak depends on the hydration state, we also analyzed mixtures with "hydrated" and "dehydrated"h smectite to examine the effects of hydration state on detection limits.

  10. Measuring Steady-State Oxygen Uptake during the 6-Min Walk Test in Adults with Cerebral Palsy: Feasibility and Construct Validity

    Science.gov (United States)

    Maltais, Desiree B.; Robitaille, Nancy-Michelle; Dumas, Francine; Boucher, Normand; Richards, Carol L.

    2012-01-01

    This study evaluated the feasibility of measuring steady-state oxygen uptake (V[Combining Dot Above]O[subscript 2]) during the 6-min walk test (6MWT) in adults with cerebral palsy (CP) who walk without support and whether there is construct validity for net 6MWT V[Combining Dot Above]O[subscript 2] as a measure of their walking ability.…

  11. Triterpenoid herbal saponins enhance beneficial bacteria, decrease sulfate-reducing bacteria, modulate inflammatory intestinal microenvironment and exert cancer preventive effects in ApcMin/+ mice

    OpenAIRE

    Chen, Lei; Brar, Manreetpal S.; Leung, Frederick C. C.; Hsiao, W. L. Wendy

    2016-01-01

    Saponins derived from medicinal plants have raised considerable interest for their preventive roles in various diseases. Here, we investigated the impacts of triterpenoid saponins isolated from Gynostemma pentaphyllum (GpS) on gut microbiome, mucosal environment, and the preventive effect on tumor growth. Six-week old ApcMin/+ mice and their wild-type littermates were fed either with vehicle or GpS daily for the duration of 8 weeks. The fecal microbiome was analyzed by enterobacterial repetit...

  12. Thermal adaptation of the crucian carp (Carassius carassius) cardiac delayed rectifier current, IKs, by homomeric assembly of Kv7.1 subunits without MinK.

    Science.gov (United States)

    Hassinen, Minna; Laulaja, Salla; Paajanen, Vesa; Haverinen, Jaakko; Vornanen, Matti

    2011-07-01

    Ectothermic vertebrates experience acute and chronic temperature changes which affect cardiac excitability and may threaten electrical stability of the heart. Nevertheless, ectothermic hearts function over wide range of temperatures without cardiac arrhythmias, probably due to special molecular adaptations. We examine function and molecular basis of the slow delayed rectifier K(+) current (I(Ks)) in cardiac myocytes of a eurythermic fish (Carassius carassius L.). I(Ks) is an important repolarizing current that prevents excessive prolongation of cardiac action potential, but it is extremely slowly activating when expressed in typical molecular composition of the endothermic animals. Comparison of the I(Ks) of the crucian carp atrial myocytes with the currents produced by homomeric K(v)7.1 and heteromeric K(v)7.1/MinK channels in Chinese hamster ovary cells indicates that activation kinetics and pharmacological properties of the I(Ks) are similar to those of the homomeric K(v)7.1 channels. Consistently with electrophysiological properties and homomeric K(v)7.1 channel composition, atrial transcript expression of the MinK subunit is only 1.6-1.9% of the expression level of the K(v)7.1 subunit. Since activation kinetics of the homomeric K(v)7.1 channels is much faster than activation of the heteromeric K(v)7.1/MinK channels, the homomeric K(v)7.1 composition of the crucian carp cardiac I(Ks) is thermally adaptive: the slow delayed rectifier channels can open despite low body temperatures and curtail the duration of cardiac action potential in ectothermic crucian carp. We suggest that the homomeric K(v)7.1 channel assembly is an evolutionary thermal adaptation of ectothermic hearts and the heteromeric K(v)7.1/MinK channels evolved later to adapt I(Ks) to high body temperature of endotherms.

  13. Metabolic effect of bodyweight whole-body vibration in a 20-min exercise session: A crossover study using verified vibration stimulus.

    Directory of Open Access Journals (Sweden)

    Chiara Milanese

    Full Text Available The ability of whole body vibration (WBV to increase energy expenditure (EE has been investigated to some extent in the past using short-term single exercises or sets of single exercises. However, the current practice in WBV training for fitness is based on the execution of multiple exercises during a WBV training session for a period of at least 20 min; nevertheless, very limited and inconsistent data are available on EE during long term WBV training session. This crossover study was designed to demonstrate, in an adequately powered sample of participants, the ability of WBV to increase the metabolic cost of exercise vs. no vibration over the time span of a typical WBV session for fitness (20 min. Twenty-two physically active young males exercised on a vibration platform (three identical sets of six different exercises using an accelerometer-verified vibration stimulus in both the WBV and no vibration condition. Oxygen consumption was measured with indirect calorimetry and expressed as area under the curve (O2(AUC. Results showed that, in the overall 20-min training session, WBV increased both the O2(AUC and the estimated EE vs. no vibration by about 22% and 20%, respectively (P<0.001 for both, partial eta squared [η2] ≥0.35 as well as the metabolic equivalent of task (+5.5%, P = 0.043; η2 = 0.02 and the rate of perceived exertion (+13%, P<0.001; ŋ2 = 0.16. Results demonstrated that vibration is able to significantly increase the metabolic cost of exercise in a 20-min WBV training session.

  14. Curcumin attenuates palmitate-induced apoptosis in MIN6 pancreatic β-cells through PI3K/Akt/FoxO1 and mitochondrial survival pathways.

    Science.gov (United States)

    Hao, Feng; Kang, Jinsen; Cao, Yajun; Fan, Shengjun; Yang, Haopeng; An, Yu; Pan, Yan; Tie, Lu; Li, Xuejun

    2015-11-01

    Lipotoxicity plays a vital role in development and progression of type 2 diabetes. Prolonged elevation of free fatty acids especially the palmitate leads to pancreatic β-cell dysfunction and apoptosis. Curcumin (diferuloylmethane), a polyphenol from the curry spice turmeric, is considered to be a broadly cytoprotective agent. The present study was designed to determine the protective effect of curcumin on palmitate-induced apoptosis in β-cells and investigate underlying mechanisms. Our results showed that curcumin improved cell viability and enhanced glucose-induced insulin secretory function in MIN6 pancreatic β-cells. Palmitate incubation evoked chromatin condensation, DNA nick end labeling and activation of caspase-3 and -9. Curcumin treatment inhibited palmitate-induced apoptosis, relieved mitochondrial depolarization and up-regulated Bcl-2/Bax ratio. Palmitate induced the generation of reactive oxygen species and inhibited activities of antioxidant enzymes, which could be neutralized by curcumin treatment. Moreover, curcumin could promote rapid phosphorylation of Akt and nuclear exclusion of FoxO1 in MIN6 cells under lipotoxic condition. Phosphatidylinositol 3-kinase and Akt specific inhibitors abolished the anti-lipotoxic effect of curcumin and stimulated FoxO1 nuclear translocation. These findings suggested that curcumin protected MIN6 pancreatic β-Cells against apoptosis through activation of Akt, inhibition of nuclear translocation of FoxO1 and mitochondrial survival pathway.

  15. Division site selection in Escherichia coli involves dynamic redistribution of Min proteins within coiled structures that extend between the two cell poles

    Science.gov (United States)

    Shih, Yu-Ling; Le, Trung; Rothfield, Lawrence

    2003-06-01

    The MinCDE proteins of Escherichia coli are required for proper placement of the division septum at midcell. The site selection process requires the rapid oscillatory redistribution of the proteins from pole to pole. We report that the three Min proteins are organized into extended membrane-associated coiled structures that wind around the cell between the two poles. The pole-to-pole oscillation of the proteins reflects oscillatory changes in their distribution within the coiled structure. We also report that the E. coli MreB protein, which is required for maintaining the rod shape of the cell, also forms extended coiled structures, which are similar to the MreB structures that have previously been reported in Bacillus subtilis. The MreB and MinCDE coiled arrays do not appear identical. The results suggest that at least two functionally distinct cytoskeletal-like elements are present in E. coli and that structures of this type can undergo dynamic changes that play important roles in division site placement and possibly other aspects of the life of the cell.

  16. Monitoring and forecasting of radiation hazard from great solar energetic particle events by using on-line one-min neutron monitor and satellite data

    International Nuclear Information System (INIS)

    Dorman, L. I.

    2007-01-01

    The method of automatically determining the start of great solar energetic particle (SEP) events are described on the basis of cosmic ray (CR) one-min observations by neutron monitors in real-time scale. It is shown that the probabilities of false alarms and missed triggers are negligible. After the start of SEP event, it is automatically determined by the method of coupling functions the SEP energy spectrum and flux for each minute of observations. By solving the inverse problem during few first minutes of SEP event, diffusion coefficient in the interplanetary space, source function on the Sun, and time of ejection of SEP into solar wind are determined. For extending obtained results into small energy range we use also available from Internet the satellite one-min CR data. This make possible to give forecast of space-time variation of SEP for more than 2 days and estimate expected radiation dose for satellite and aircraft. With each new minute of observations, the quality of forecast increased, and after ∼30 min became near 100%. (authors)

  17. Henrik Gottlieb and Jens Erik Mogensen (Editors). Dictionary ...

    African Journals Online (AJOL)

    rbr

    for the empirical analyses on which the papers are based, often deal with the ... and printed reference works cannot keep up with the pace of change. In addi- tion, new ... forms in a particular language and its implications for lexicographical activities such as corpus .... The accounting dictionary under discussion is conceptu-.

  18. Water treatment process in the JEN-1 Research Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Urgel, M; Perez-Bustamante, J A; Batuecas, T

    1965-07-01

    The main characteristics and requirements which must be met with by waters to be used for nuclear reactors were studied paying attention separately both to those used in primary and secondary circuits as well as to the purification systems to be employed in each case. The experiments carried out for the initial pretreatment of water and the ion-exchange de ionization processes including a number of systems consisting of separated and mixed beds loaded with a variety of different commercially available resins are described. (Author) 24 refs.

  19. Øjenåbnere og erfaring i universelt design

    DEFF Research Database (Denmark)

    Grangaard, Sidse

    2016-01-01

    and the students. The concept of "experience" and "eye-opener" is introduced and used as an analytical framework. Both of the concepts are characterised by a relation to the episodic memory and the concept of context-dependent knowledge. During the competition, knowledge about the users is integrated in the design...

  20. Water treatment process in the JEN-1 Research Reactors

    International Nuclear Information System (INIS)

    Urgel, M.; Perez-Bustamante, J. A.; Batuecas, T.

    1965-01-01

    The main characteristics and requirements which must be met with by waters to be used for nuclear reactors were studied paying attention separately both to those used in primary and secondary circuits as well as to the purification systems to be employed in each case. The experiments carried out for the initial pretreatment of water and the ion-exchange de ionization processes including a number of systems consisting of separated and mixed beds loaded with a variety of different commercially available resins are described. (Author) 24 refs

  1. Helsinki Stroke Model Is Transferrable With “Real-World” Resources and Reduced Stroke Thrombolysis Delay to 34 min in Christchurch

    Directory of Open Access Journals (Sweden)

    Teddy Y. Wu

    2018-04-01

    Full Text Available BackgroundChristchurch hospital is a tertiary hospital in New Zealand supported by five general neurologists with after-hours services provided mainly by onsite non-neurology medical residents. We assessed the transferrability and impact of the Helsinki Stroke model on stroke thrombolysis door-to-needle time (DNT in Christchurch hospital.MethodsKey components of the Helsinki Stroke model were implemented first in 2015 with introduction of patient pre-notification and thrombolysis by the computed tomography (CT suite, followed by implementation of direct transfer to CT on ambulance stretcher in May 2017. Data from the prospective thrombolysis registry which began in 2012 were analyzed for the impact of these interventions on median DNT.ResultsBetween May and December 2017, 46 patients were treated with alteplase, 25 (54% patients were treated in-hours (08:00–17:00 non-public holiday weekdays and 21 (46% patients were treated after-hours. The in-hours, after-hours, and overall median (interquartile range DNTs were 34 (28–43, 47 (38–60, and 40 (30–51 minutes. The corresponding times in 2012–2014 prior to interventions were 87 (68–106, 86 (72–116, and 87 (71–112 minutes, representing median DNT reduction of 53, 39, and 47 minutes, respectively (p-values <0.01. The interventions also resulted in significant reductions in the overall median door-to-CT time (from 49 to 19 min, CT-to-needle time (32 to 20 min and onset-to-needle time (168 to 120 min.ConclusionThe Helsinki stroke model is transferrable with real-world resources and reduced stroke DNT in Christchurch by over 50%.

  2. Association of serum orosomucoid with 30-min plasma glucose and glucose excursion during oral glucose tolerance tests in non-obese young Japanese women.

    Science.gov (United States)

    Tsuboi, Ayaka; Minato, Satomi; Yano, Megumu; Takeuchi, Mika; Kitaoka, Kaori; Kurata, Miki; Yoshino, Gen; Wu, Bin; Kazumi, Tsutomu; Fukuo, Keisuke

    2018-01-01

    Inflammatory markers are elevated in insulin resistance (IR) and diabetes. We tested whether serum orosomucoid (ORM) is associated with postload glucose, β-cell dysfunction and IR inferred from plasma insulin kinetics during a 75 g oral glucose tolerance test (OGTT). 75 g OGTTs were performed with multiple postload glucose and insulin measurements over a 30-120 min period in 168 non-obese Japanese women (aged 18-24 years). OGTT responses, serum adiponectin and high-sensitivity C reactive protein (hsCRP) were cross-sectionally analyzed by analysis of variance and then Bonferroni's multiple comparison procedure. Stepwise multivariate linear regression analyses were used to identify most important determinants of ORM. Of 168 women, 161 had normal glucose tolerance. Postload glucose levels and the area under the glucose curve (AUCg) increased in a stepwise fashion from the first through the third ORM tertile. In contrast, there was no or modest, if any, association with fat mass index, trunk/leg fat ratio, adiponectin, hsCRP, postload insulinemia, the Matsuda index and homeostasis model assessment IR. In multivariable models, which incorporated the insulinogenic index, the Matsuda index and HOMA-IR, 30 min glucose (standardized β: 0.517) and AUCg (standardized β: 0.495) explained 92.8% of ORM variations. Elevated circulating orosomucoid was associated with elevated 30 min glucose and glucose excursion in non-obese young Japanese women independently of adiposity, IR, insulin secretion, adiponectin and other investigated markers of inflammation. Although further research is needed, these results may suggest a clue to identify novel pathways that may have utility in monitoring dysglycemia within normal glucose tolerance.

  3. Reproducibility of automated simplified voxel-based analysis of PET amyloid ligand [11C]PIB uptake using 30-min scanning data

    International Nuclear Information System (INIS)

    Aalto, Sargo; Scheinin, Noora M.; Naagren, Kjell; Rinne, Juha O.; Kemppainen, Nina M.; Kailajaervi, Marita; Leinonen, Mika; Scheinin, Mika

    2009-01-01

    Positron emission tomography (PET) with 11 C-labelled Pittsburgh compound B ([ 11 C]PIB) enables the quantitation of β-amyloid accumulation in the brain of patients with Alzheimer's disease (AD). Voxel-based image analysis techniques conducted in a standard brain space provide an objective, rapid and fully automated method to analyze [ 11 C]PIB PET data. The purpose of this study was to evaluate both region- and voxel-level reproducibility of automated and simplified [ 11 C]PIB quantitation when using only 30 min of imaging data. Six AD patients and four healthy controls were scanned twice with an average interval of 6 weeks. To evaluate the feasibility of short scanning (convenient for AD patients), [ 11 C]PIB uptake was quantitated using 30 min of imaging data (60 to 90 min after tracer injection) for region-to-cerebellum ratio calculations. To evaluate the reproducibility, a test-retest design was used to derive absolute variability (VAR) estimates and intraclass correlation coefficients at both region-of-interest (ROI) and voxel level. The reproducibility both at the region level (VAR 0.9-5.5%) and at the voxel level (VAR 4.2-6.4%) was good to excellent. Based on the variability estimates obtained, power calculations indicated that 90% power to obtain statistically significant difference can be achieved using a sample size of five subjects per group when a 15% change from baseline (increase or decrease) in [ 11 C]PIB accumulation in the frontal cortex is anticipated in one group compared to no change in another group. Our results showed that an automated analysis method based on an efficient scanning protocol provides reproducible results for [ 11 C]PIB uptake and appears suitable for PET studies aiming at the quantitation of amyloid accumulation in the brain of AD patients for the evaluation of progression and treatment effects. (orig.)

  4. Triterpenoid herbal saponins enhance beneficial bacteria, decrease sulfate-reducing bacteria, modulate inflammatory intestinal microenvironment and exert cancer preventive effects in ApcMin/+ mice

    Science.gov (United States)

    Chen, Lei; Brar, Manreetpal S.; Leung, Frederick C. C.; Hsiao, W. L. Wendy

    2016-01-01

    Saponins derived from medicinal plants have raised considerable interest for their preventive roles in various diseases. Here, we investigated the impacts of triterpenoid saponins isolated from Gynostemma pentaphyllum (GpS) on gut microbiome, mucosal environment, and the preventive effect on tumor growth. Six-week old ApcMin/+ mice and their wild-type littermates were fed either with vehicle or GpS daily for the duration of 8 weeks. The fecal microbiome was analyzed by enterobacterial repetitive intergenic consensus (ERIC)-PCR and 16S rRNA gene pyrosequencing. Study showed that GpS treatment significantly reduced the number of intestinal polyps in a preventive mode. More importantly, GpS feeding strikingly reduced the sulfate-reducing bacteria lineage, which are known to produce hydrogen sulfide and contribute to damage the intestinal epithelium or even promote cancer progression. Meanwhile, GpS also boosted the beneficial microbes. In the gut barrier of the ApcMin/+ mice, GpS treatment increased Paneth and goblet cells, up-regulated E-cadherin and down-regulated N-cadherin. In addition, GpS decreased the pro-oncogenic β-catenin, p-Src and the p-STAT3. Furthermore, GpS might also improve the inflamed gut epithelium of the ApcMin/+ mice by upregulating the anti-inflammatory cytokine IL-4, while downregulating pro-inflammatory cytokines TNF-β, IL-1β and IL-18. Intriguingly, GpS markedly stimulated M2 and suppressed M1 macrophage markers, indicating that GpS altered mucosal cytokine profile in favor of the M1 to M2 macrophages switching, facilitating intestinal tissue repair. In conclusion, GpS might reverse the host's inflammatory phenotype by increasing beneficial bacteria, decreasing sulfate-reducing bacteria, and alleviating intestinal inflammatory gut environment, which might contribute to its cancer preventive effects. PMID:27121311

  5. A review of short naps and sleep inertia: do naps of 30 min or less really avoid sleep inertia and slow-wave sleep?

    Science.gov (United States)

    Hilditch, Cassie J; Dorrian, Jillian; Banks, Siobhan

    2017-04-01

    Napping is a widely used countermeasure to sleepiness and impaired performance caused by sleep loss and circadian pressure. Sleep inertia, the period of grogginess and impaired performance experienced after waking, is a potential side effect of napping. Many industry publications recommend naps of 30 min or less to avoid this side effect. However, the evidence to support this advice is yet to be thoroughly reviewed. Electronic databases were searched, and defined criteria were applied to select articles for review. The review covers literature on naps of 30 min or less regarding (a) sleep inertia, (b) slow-wave sleep (SWS) and (c) the relationship between sleep inertia and SWS. The review found that although the literature on short afternoon naps is relatively comprehensive, there are very few studies on naps of 30 min or less at night. Studies have mixed results regarding the onset of SWS and the duration and severity of sleep inertia following short naps, making guidelines regarding their use unclear. The varying results are likely due to differing sleep/wake profiles before the nap of interest and the time of the day at waking. The review highlights the need to have more detailed guidelines about the implementation of short naps according to the time of the day and prior sleep/wake history. Without this context, such a recommendation is potentially misleading. Further research is required to better understand the interactions between these factors, especially at night, and to provide more specific recommendations. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Évolution des teneurs en éléments minéraux des feuilles de niébé ...

    African Journals Online (AJOL)

    Objectif : Le niébé (Vigna unguiculata (L.) Walp.) est une légumineuse dont les feuilles peuvent être utilisées dans l'alimentation du bétail. L'objectif de l'étude est d'apprécier l'évolution des teneurs en éléments minéraux des feuilles de niébé au cours de son cycle de développent et de déceler la meilleure période de ...

  7. The investigation of in-vivo measurement of individual renal blood perfusion, effective renal plasma flow and quantitation of renogram and 15 min bladder collection percentage

    International Nuclear Information System (INIS)

    Huang Kangchu

    1991-01-01

    25 normals and 43 renal diseases were examined by the RBF-I multifunctioning renography. The result showed that the determination of ERPF has no difference between blood sampling and noin-blood sampling method, and actually the lattrer can replace the former one. Above method can be also used for the measurement of the individual renal blood perfusion, the quantitation of renogram and the 15 min bladder coolection percentage at the same time. Thereby it provides more complete diagnostic information for the renal vascular diseases, renal pancren chymations and other urologic diseases

  8. Évolution des teneurs en éléments minéraux des feuilles de niébé ...

    African Journals Online (AJOL)

    SARAH

    31 juil. 2014 ... Objectif : Le niébé (Vigna unguiculata (L.) Walp.) est une légumineuse dont les feuilles peuvent être utilisées dans l'alimentation du bétail. L'objectif de l'étude est d'apprécier l'évolution des teneurs en éléments minéraux des feuilles de niébé au cours de son cycle de développent et de déceler la meilleure.

  9. Lung transfer factor and KCO at cardiac frequency 100 beats/min as a guide to impaired function of lung parenchyma.

    OpenAIRE

    Chu, S S; Cotes, J E

    1984-01-01

    Transfer factor (TL) and KCO have been measured by the single breath carbon monoxide method in 39 patients with confirmed or suspected lung disease, mostly of occupational origin, and 37 healthy subjects. TL and KCO at an exercise cardiac frequency of 100 beats/min (TL100 and KCO100) and the slopes of the regression of exercise transfer factor and KCO on exercise cardiac frequency (delta TL/delta fC and delta KCO/delta fC) were obtained. The discriminatory performance of these indices in dete...

  10. La comunicación organizacional satisfactoria en el ministerio de tecnologías de la información y las comunicaciones (Min TIC) de Colombia

    OpenAIRE

    Jiménez Estrada, Néstor Alonso

    2017-01-01

    Propósito – Evidenciar, con el rigor de la investigación científica en administración, la dificultad en la comunicación organizacional (LCO) del Ministerio de Tecnologías de la Información y las Comunicaciones (Min TIC), describiendo cómo es esta desde el punto de vista del Cuestionario sobre la Satisfacción en la Comunicación (CSQ), con el fin de plantear una propuesta encaminada a mejorarla objetivamente. Diseño/metodología/enfoque – Es un estudio descriptivo basado en el uso de un mono-...

  11. Loss of PACS-2 delays regeneration in DSS-induced colitis but does not affect the ApcMin model of colorectal cancer

    DEFF Research Database (Denmark)

    Dombernowsky, Sarah L.; Schwarz, Jeanette; Samsøe-Petersen, Jacob

    2017-01-01

    in these processes. Specifically, we analyzed the role of Pacs2- deficiency in a DSS-induced colitis model as well as in the genetic ApcMin colon cancer model. We now report that loss of PACS-2 delays tissue regeneration after colonic injury with little effect on key inflammatory parameters. We did however...... not observe any apparent effects on tumor formation driven by excessive proliferative signaling downstream from APC-deficiency. Our findings reveal that the role of PACS- 2 in regulating ADAM17-mediated shedding is not an obligate requirement for the epithelium to respond to the strong inflammatory...

  12. Les consommations d'énergie dans l'industrie minérale (résumé Energy Consumption in the Mineral Industry (Summary

    Directory of Open Access Journals (Sweden)

    Gentilhomme P. H.

    2006-11-01

    Full Text Available Dans le cadre limité de cette présentation, il était préférable de placer l'accent, non sur les évaluations du coût énergétique des diverses substances minérales, mais plutôt sur les paramètres de ces coûts, leur évolution récente et leur devenir dans une prospective à moyen terme, questions susceptibles d'alimenter ensuite les discussions. Après un bref rappel méthodologique, seront successivement examinés : - d'un point de vue global, la consommation d'énergie de l'industrie minérale, sa répartition et son évolution par formes d'énergie mises en oeuvre ; - d'un point de vue analytique, la nature des facteurs qui régissent les coûts énergétiques miniers, minéralurgiques et métallurgiques, les tendances récentes constatées et leurs implications pour l'avenir ; - d'un point de vue prospectif, enfin, quelques-uns des remèdes - ou palliatifs ? - à l'élévation des coûts énergétiques des substances minérales. Within the required time for the presentation of this paper, it was more advisable to emphasize, not the sizing up of the energy cost of mineral raw materials and products, but rather the parameters of thes costs, and their evolution, actual and in a medium-term prospective, questions of eventual interest for the discussions. After a short recall of methodology, we have to examine successively: - on a global standpoint, the energy consumption of the mineral industry, the breakdown of this consumption by forms of energy used, and its evolution; - on an analytical standpoint, the main factors which direct the energy requirements in mining, beneficiating and smeltinq operations, the trends that are observed and their results for the future; - on a prospective standpoint, at last, what are the possibilities to cut off - or palliate? - the increase of the mineral commodities energy costs.

  13. Minério de ferro, geologia econômica e redes de expertsentre Wisconsin e Minas Gerais, 1881-1914

    Directory of Open Access Journals (Sweden)

    Georg Fischer

    2014-03-01

    Full Text Available O presente artigo trata da “descoberta” do minério de ferro brasileiro a partir de duas perspectivas. A primeira analisa a crescente ênfase das geociências em sua aplicação prática e em sua globalidade desde a segunda metade do século XIX. Enquanto no Brasil a geologia econômica foi integrada passo a passo às instituições do Estado, no nível global ela viveu momento de triunfo com o 11o Congresso Geológico Internacional, em 1910. A segunda trata de uma rede social específica com papel decisivo na corrida pelo minério de ferro brasileiro: experts transnacionais movimentandose entre as lógicas do mercado e as da academia. O artigo mostra a importância das negociações locais na incorporação do subsolo mineiro ao espaço global de mineração.

  14. Linear and nonlinear dynamics of heart rate variability in the process of exposure to 3600 m in 10 min.

    Science.gov (United States)

    Zhang, Da; She, Jin; Yang, Jun; Yu, Mengsun

    2015-06-01

    Acute hypoxia activates several autonomic mechanisms, mainly in cardiovascular system and respiratory system. The influence of acute hypoxia on linear and nonlinear heart rate variability (HRV) has been studied, but the parameters in the process of hypoxia are still unclear. Although the changes of HRV in frequency domain are related to autonomic responses, how nonlinear dynamics change with the decrease of ambient atmospheric pressure is unknown either. Eight healthy male subjects were exposed to simulated altitude from sea level to 3600 m in 10 min. HRV parameters in frequency domain were analyzed by wavelet packet transform (Daubechies 4, 4 level) followed by Hilbert transform to assess the spectral power of modified low frequency (0.0625-0.1875 Hz, LFmod), modified high frequency (0.1875-0.4375 Hz, HFmod), and the LFmod/HFmod ratio in every 1 min. Nonlinear parameters were also quantified by sample entropy (SampEn) and short term fractal correlation exponent (α1) in the process. Hypoxia was associated with the depression of both LFmod and HFmod component. They were significantly lower than that at sea level at 3600 m and 2880 m respectively (both p nonlinear HRV parameters continuously in the process of hypoxia would be an effective way to evaluate the different regulatory mechanisms of autonomic nervous system.

  15. Comparative Analyses between Skeletal Muscle miRNAomes from Large White and Min Pigs Revealed MicroRNAs Associated with Postnatal Muscle Hypertrophy.

    Science.gov (United States)

    Sheng, Xihui; Wang, Ligang; Ni, Hemin; Wang, Lixian; Qi, Xiaolong; Xing, Shuhan; Guo, Yong

    2016-01-01

    The molecular mechanism regulated by microRNAs (miRNAs) that underlies postnatal hypertrophy of skeletal muscle is complex and remains unclear. Here, the miRNAomes of longissimus dorsi muscle collected at five postnatal stages (60, 120, 150, 180, and 210 days after birth) from Large White (commercial breed) and Min pigs (indigenous breed of China) were analyzed by Illumina sequencing. We identified 734 miRNAs comprising 308 annotated miRNAs and 426 novel miRNAs, of which 307 could be considered pig-specific. Comparative analysis between two breeds suggested that 60 and 120 days after birth were important stages for skeletal muscle hypertrophy and intramuscular fat accumulation. A total of 263 miRNAs were significantly differentially expressed between two breeds at one or more developmental stages. In addition, the differentially expressed miRNAs between every two adjacent developmental stages in each breed were determined. Notably, ssc-miR-204 was significantly more highly expressed in Min pig skeletal muscle at all postnatal stages compared with its expression in Large White pig skeletal muscle. Based on gene ontology and KEGG pathway analyses of its predicted target genes, we concluded that ssc-miR-204 may exert an impact on postnatal hypertrophy of skeletal muscle by regulating myoblast proliferation. The results of this study will help in elucidating the mechanism underlying postnatal hypertrophy of skeletal muscle modulated by miRNAs, which could provide valuable information for improvement of pork quality and human myopathy.

  16. Actin-based vesicular transport in the first 20 min after dusk is crucial for daily rhabdom synthesis in the compound eye of the grapsid crab Hemigrapsus sanguineus.

    Science.gov (United States)

    Matsushita, A; Arikawa, K

    1997-09-01

    In the crab Hemigrapsus sanguineus, maintained under a 12 h:12 h light:dark cycle, the amount of vesicular smooth endoplasmic reticulum (vesicular sER) in the photoreceptor cell body increases after the light is turned off. This paper demonstrates that actin filaments in the photoreceptor cell body are involved in the transport of vesicular sER towards the rhabdom. To specify the time of actin contribution to rhabdom synthesis, we disrupted the organization of actin filaments in the cell body with cytochalasin D at various time around dusk. We then measured the rhabdom size and also examined the ultrastructure of the photoreceptor cell body 3 h after extinguishing the light. When cytochalasin D was applied from either 1 h before or immediately after extinguishing the light, the rhabdom size did not increase, whereas vesicular sER accumulated in the cell body. In contrast, cytochalasin D applied to the eyes from 20 min after turning the light off did not inhibit rhabdom synthesis. These results indicate that the first 20 min after the light is turned off is particularly important for the transport of vesicular sER towards the rhabdom by the cell body actin filaments.

  17. The Intrauterine and Nursing Period Is a Window of Susceptibility for Development of Obesity and Intestinal Tumorigenesis by a High Fat Diet in Min/+ Mice as Adults

    Directory of Open Access Journals (Sweden)

    Ha Thi Ngo

    2015-01-01

    Full Text Available We studied how obesogenic conditions during various life periods affected obesity and intestinal tumorigenesis in adult C57BL/6J-Min (multiple intestinal neoplasia/+ mice. The mice were given a 10% fat diet throughout life (negative control or a 45% fat diet in utero, during nursing, during both in utero and nursing, during adult life, or during their whole life-span, and terminated at 11 weeks for tumorigenesis (Min/+ or 23 weeks for obesogenic effect (wild-type. Body weight at 11 weeks was increased after a 45% fat diet during nursing, during both in utero and nursing, and throughout life, but had normalized at 23 weeks. In the glucose tolerance test, the early exposure to a 45% fat diet in utero, during nursing, or during both in utero and nursing, did not affect blood glucose, whereas a 45% fat diet given to adults or throughout life did. However, a 45% fat diet during nursing or during in utero and nursing increased the number of small intestinal tumors. So did exposures to a 45% fat diet in adult life or throughout life, but without increasing the tumor numbers further. The intrauterine and nursing period is a window of susceptibility for dietary fat-induced obesity and intestinal tumor development.

  18. Marmara Bölgesi'nde Arpa açık rastığı (Ustilago nuda hordeiJens.â€? Rostr. Schaffn.)'na karşı arpa çeşit ve hatlarının reaksiyonlarının tespiti üzerinde araştırmalar.

    OpenAIRE

    Gümüştekin, H.; Akın, K.

    2008-01-01

    Arpa çeşit ve hatlarının, arpa açık rastık hastalığı (Ustilago nuda hordei “Jens.â€? Rostr. Schaffn.)'na karşı göstermiş olduğu reaksiyonları tespit etmek amacı ile bu çalışma 1994 yılında başlamıştır. 1994 Yılında 14 arpa çeşit ve hattı, 1995 yılında 23 arpa çeşit ve hattı kullanılmıştır. Denemelerde kullanılan 37 çeşit ve hattan 27'si hastalığa karşı dayanıklı (R) bulunurken, 10'u hassas (S) bulunmuştur.

  19. Fibroblast Growth Factor-23 and Vitamin D Metabolism in Subjects with eGFR ≥60 ml/min/1.73 m².

    Science.gov (United States)

    Nakatani, Shinya; Nakatani, Ayumi; Tsugawa, Naoko; Yamada, Shinsuke; Mori, Katsuhito; Imanishi, Yasuo; Ishimura, Eiji; Okano, Toshio; Inaba, Masaaki

    2015-01-01

    Fibroblast growth factor (FGF)-23 and parathyroid hormone (PTH) are both potent phosphaturic hormones. Since they exert opposite effects on vitamin D metabolism, the measurement of 3 vitamin D metabolites; 25-hydroxyvitamin D (25-OH-D), 1,25-dihydroxyvitamin D (1,25(OH)2D), and 24,25-dihydroxyvitamin D (24,25(OH)2D), allows the distinction of the effects of FGF-23 from those of PTH. The aim of this study was to elucidate which factor, FGF-23 or PTH, plays a more important role in the regulation of vitamin D metabolites in subjects with estimated glomerular filtration (eGFR) ≥60 ml/min/1.73 m(2). Subjects with eGFR ≥60 ml/min/1.73 m(2) (n = 20) were enrolled and their serum levels of FGF-23, intact PTH, and vitamin D metabolites were determined. Serum FGF-23 correlated inversely with 1,25(OH)2D (r = -0.717, p = 0.0004) and the 1,25(OH)2D/25-OH-D ratio (r = -0.518, p = 0.019), compared with a significant positive correlation between serum intact PTH and the 1,25(OH)2D/25-OH-D ratio (r = 0.562, p = 0.010). Multiple regression analyses revealed serum FGF-23 as a significant factor that was associated with serum 1,25(OH)2D (β = -0.593, p = 0.018), 1,25(OH)2D/25-OH-D ratio (β = -0.521, p = 0.025), and the 24,25(OH)2D/1,25(OH)2D ratio (β = 0.632, p = 0.008), and intact PTH as a significant factor associated with the 1,25(OH)2D/25-OH-D ratio (β = 0.445, p = 0.028). This study demonstrated that, even in subjects with eGFR ≥60 ml/min/1.73 m(2), FGF-23 might play an important role in the regulation of vitamin D metabolism. In addition to the established role of PTH, the association between FGF-23 and indices of vitamin D metabolism suggested the potential role of FGF-23 on phosphate metabolism in such patients. © 2015 S. Karger AG, Basel.

  20. Aplicação de extensor de cadeia e emulsificante na flotação de minério de ferro.

    OpenAIRE

    Silva, José Pedro da; Imbelloni, Alaine Moreira; Pereira, Carlos Alberto

    2013-01-01

    Este trabalho tem como objetivo avaliar o desempenho da flotação reversa de minério de ferro, usando coletor (amina), na presença e na ausência de extensor de cadeia (óleo diesel) e emulsificante (lauril sulfato de sódio). Foram realizados seis ensaios de flotação com duplicata. Os ensaios utilizando amina, óleo diesel e lauril sulfato de sódio são os que mostram um melhor resultando, apresentando recuperação metálica de 91,82% e sílica no concentrado igual a 1,68%. Assim, comprova-se que o u...

  1. Competições e festivais na Grécia Pré-Helênica: as evidências minóico-micênicas

    OpenAIRE

    Ana Claudia Torralvo

    1997-01-01

    O que conhecemos das competições desportivas e dos festivais durante a Idade do Bronze na Grécia e no Egeu chegou até nós através das imagens representadas sobre os mais diversos suportes, como os afrescos, os relevos, a glíptica e outras manifestações da arte desse período. Neles percebemos algumas atividades físicas que podem caracterizar práticas desportivas: a luta corporal, praticada com luvas de couro, e a corrida, ambas comuns ao universo minóico-micênico. Já a tauromaquia ou salto do ...

  2. Applications of a saving method with max-min ant system to a vehicle routing problem with time windows and speed limits

    Directory of Open Access Journals (Sweden)

    Suphan Sodsoon

    2014-06-01

    Full Text Available This study aims to solve a Vehicle Routing Problem with Time Windows and Speed Limits (VRPTWSL, which has received considerable attention in recent years. The vehicle routing problem with time windows is an extension of the well-known Vehicle Routing Problem (VRP and involves a fleet of vehicles set of from a depot to serve a number of customers at different geographic locations with various demands within specific time and speed limits before returning to the depot eventually. To solve the problem, an efficient Saving Method-Max Min Ant System (Saving-MMAS with Local Search algorithm is applied. Using minimization of the total transportation costs as the objective of the extension VRPTWSL, a mathematic model is constructed. Finally, the Saving-MMAS algorithms indicated the good quality of the method in this problem.

  3. Evaluation of the 115In(n,n)/sup 115m/In reaction for the ENDF/B-V dosimetry file

    International Nuclear Information System (INIS)

    Smith, D.L.

    1976-12-01

    An evaluation of the 115 In(n,n')/sup 115m/In reaction for the ENDF/B-V Dosimetry File is presented. This evaluation is based entirely on reported experimental differential data. Several data sets were renormalized prior to the evaluation in order to take into account recent adjustments in corresponding standard cross sections and in other nuclear parameters used for derivation of cross sections. The present evaluation is compared with the corresponding ENDF/B-IV evaluation. The value of the spectrum-average cross section for the standard neutron field resulting from thermal-neutron fission of 235 U has been computed for this reaction using cross section values from the present evaluation. This computed cross section compares favorably with the result of a recent evaluation of integral data

  4. Influence de la concentration de la solution nutritive sur la croissance et la nutrition minérale de la tomate

    OpenAIRE

    Morard, Philippe; Caumes, Edith; Silvestre, Jérôme

    2004-01-01

    L’influence de deux concentrations de solution nutritive a été étudiée sur la croissance et la nutrition minérale de la tomate en culture hydroponique sous serre au stade début floraison. La force ionique de la solution nutritive la plus concentrée était de 20.00 meq L–1 (SNC), valeur proche de celle qui est habituellement utilisée pour la culture de la tomate ; celle de la solution diluée (SND) était de 3.25 meq L–1. Pendant les deux semaines de l’expérimentation, la concentration du milieu ...

  5. Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in ApcMin/+ mice

    Directory of Open Access Journals (Sweden)

    Brudvik Kristoffer W

    2011-12-01

    Full Text Available Abstract Background The adenomatous polyposis coli (APC protein is part of the destruction complex controlling proteosomal degradation of β-catenin and limiting its nuclear translocation, which is thought to play a gate-keeping role in colorectal cancer. The destruction complex is inhibited by Wnt-Frz and prostaglandin E2 (PGE2 - PI-3 kinase pathways. Recent reports show that PGE2-induced phosphorylation of β-catenin by protein kinase A (PKA increases nuclear translocation indicating two mechanisms of action of PGE2 on β-catenin homeostasis. Findings Treatment of ApcMin/+ mice that spontaneously develop intestinal adenomas with a PKA antagonist (Rp-8-Br-cAMPS selectively targeting only the latter pathway reduced tumor load, but not the number of adenomas. Immunohistochemical characterization of intestines from treated and control animals revealed that expression of β-catenin, β-catenin nuclear translocation and expression of the β-catenin target genes c-Myc and COX-2 were significantly down-regulated upon Rp-8-Br-cAMPS treatment. Parallel experiments in a human colon cancer cell line (HCT116 revealed that Rp-8-Br-cAMPS blocked PGE2-induced β-catenin phosphorylation and c-Myc upregulation. Conclusion Based on our findings we suggest that PGE2 act through PKA to promote β-catenin nuclear translocation and tumor development in ApcMin/+ mice in vivo, indicating that the direct regulatory effect of PKA on β-catenin nuclear translocation is operative in intestinal cancer.

  6. Comparison of a fast 5-min knee MRI protocol with a standard knee MRI protocol. A multi-institutional multi-reader study

    Energy Technology Data Exchange (ETDEWEB)

    FitzGerald Alaia, Erin; Beltran, Luis S.; Garwood, Elisabeth; Burke, Christopher J.; Gyftopoulos, Soterios [NYU Langone Medical Center, Department of Radiology, Musculoskeletal Division, New York, NY (United States); Benedick, Alex [Case Western Reserve University, School of Medicine, Cleveland, OH (United States); Obuchowski, Nancy A. [Cleveland Clinic, Department of Quantitative Health Sciences, Cleveland, OH (United States); Polster, Joshua M.; Schils, Jean; Subhas, Naveen [Cleveland Clinic, Department of Radiology, Musculoskeletal Division, Cleveland, OH (United States); Chang, I. Yuan Joseph [Texas Scottish Rite Hospital for Children, Dallas, TX (United States)

    2018-01-15

    To compare diagnostic performance of a 5-min knee MRI protocol to that of a standard knee MRI. One hundred 3 T (100 patients, mean 38.8 years) and 50 1.5 T (46 patients, mean 46.4 years) MRIs, consisting of 5 fast, 2D multi-planar fast-spin-echo (FSE) sequences and five standard multiplanar FSE sequences, from two academic centers (1/2015-1/2016), were retrospectively reviewed by four musculoskeletal radiologists. Agreement between fast and standard (interprotocol agreement) and between standard (intraprotocol agreement) readings for meniscal, ligamentous, chondral, and bone pathology was compared for interchangeability. Frequency of major findings, sensitivity, and specificity was also tested for each protocol. Interprotocol agreement using fast MRI was similar to intraprotocol agreement with standard MRI (83.0-99.5%), with no excess disagreement (≤ 1.2; 95% CI, -4.2 to 3.8%), across all structures. Frequency of major findings (1.1-22.4% across structures) on fast and standard MRI was not significantly different (p ≥ 0.215), except more ACL tears on fast MRI (p = 0.021) and more cartilage defects on standard MRI (p < 0.001). Sensitivities (59-100%) and specificities (73-99%) of fast and standard MRI were not significantly different for meniscal and ligament tears (95% CI for difference, -0.08-0.08). For cartilage defects, fast MRI was slightly less sensitive (95% CI for difference, -0.125 to -0.01) but slightly more specific (95% CI for difference, 0.01-0.5) than standard MRI. A fast 5-min MRI protocol is interchangeable with and has similar accuracy to a standard knee MRI for evaluating internal derangement of the knee. (orig.)

  7. Comparison of a fast 5-min knee MRI protocol with a standard knee MRI protocol. A multi-institutional multi-reader study

    International Nuclear Information System (INIS)

    FitzGerald Alaia, Erin; Beltran, Luis S.; Garwood, Elisabeth; Burke, Christopher J.; Gyftopoulos, Soterios; Benedick, Alex; Obuchowski, Nancy A.; Polster, Joshua M.; Schils, Jean; Subhas, Naveen; Chang, I. Yuan Joseph

    2018-01-01

    To compare diagnostic performance of a 5-min knee MRI protocol to that of a standard knee MRI. One hundred 3 T (100 patients, mean 38.8 years) and 50 1.5 T (46 patients, mean 46.4 years) MRIs, consisting of 5 fast, 2D multi-planar fast-spin-echo (FSE) sequences and five standard multiplanar FSE sequences, from two academic centers (1/2015-1/2016), were retrospectively reviewed by four musculoskeletal radiologists. Agreement between fast and standard (interprotocol agreement) and between standard (intraprotocol agreement) readings for meniscal, ligamentous, chondral, and bone pathology was compared for interchangeability. Frequency of major findings, sensitivity, and specificity was also tested for each protocol. Interprotocol agreement using fast MRI was similar to intraprotocol agreement with standard MRI (83.0-99.5%), with no excess disagreement (≤ 1.2; 95% CI, -4.2 to 3.8%), across all structures. Frequency of major findings (1.1-22.4% across structures) on fast and standard MRI was not significantly different (p ≥ 0.215), except more ACL tears on fast MRI (p = 0.021) and more cartilage defects on standard MRI (p < 0.001). Sensitivities (59-100%) and specificities (73-99%) of fast and standard MRI were not significantly different for meniscal and ligament tears (95% CI for difference, -0.08-0.08). For cartilage defects, fast MRI was slightly less sensitive (95% CI for difference, -0.125 to -0.01) but slightly more specific (95% CI for difference, 0.01-0.5) than standard MRI. A fast 5-min MRI protocol is interchangeable with and has similar accuracy to a standard knee MRI for evaluating internal derangement of the knee. (orig.)

  8. Comparison of functional ramp walk test and 6-min walk test in healthy volunteers: A new approach in functional capacity evaluation

    Directory of Open Access Journals (Sweden)

    Manivel Arumugam

    2017-01-01

    Full Text Available Objective: Inclined surfaces or ramps are the common obstacles faced by elderly and cardiopulmonary disabled in accessing public amenities. Ramp walking is one of the most common functional demands to be met by a common man in the industrialized world. To assess the functional (uphill walking capacity, we need a different functional stress test over the routinely used 6-min walk test (6MWT. Hence, a new 3-min steep ramp walk test (3MRWT was constructed to meet the demands similar to an uphill walk and to provide more functional stress than routinely used 6MWT. Methodology: The observational, crossover study design was adopted for this study. Fifteen healthy participants (8 males, 7 females performed both tests in a randomized order with a washout time of 6 h in between the tests. Walking distance to both ramp and ground, heart rate, blood pressure, saturation (SpO2, dyspnea, and fatigue with Borg exertion scale were compared prior and after the two walk tests. Results: The average distances covered in 6MWT were 510.5 ± 55.06 and 440.65 ± 25.08 meters and in 3MRWT were 270.18 ± 30.8, 230.05 ± 15.06 meters for male and female respectively. The difference between 3MRWT and 6MWT distances covered by the participants was statistically significant (t = 0.893. The mean difference between the heart rate, saturation and perceptions were highly significant (P < 0.001. Conclusion: The study results show that 3MRWT is valid over routinely administered 6MWT and may provide greater functional stress (uphill or ramp walk capacity in a shorter duration in healthy individuals in assessing the maximal functional capacity in a ramp or uphill walking.

  9. "Mu vend mu õde ja mina põgeneme Valguskoonused kalduvad ..." = "Min bror min syster och jag flyr Ljuskäglor välter över vägkanten ..." : [luuletused] / Catharina Gripenberg ; tlk. Juta-Tiia Mägi

    Index Scriptorium Estoniae

    Gripenberg, Catharina

    2004-01-01

    Sisu: "Mu vend mu õde ja mina põgeneme Valguskoonused kalduvad ..." = "Min bror min syster och jag flyr Ljuskäglor välter över vägkanten ..."; "Tean, et kajad vastavad, aga väga lühidalt. Valad sa välja oma ..." = "Vet att ekon svarar, men i all korthet. Gjuter du ut ditt hjärta ..."; "Kirjasõber, ma otsin välja jääkraabitsa ..." = "Brevvän, jag lagrar upp med fönsterskapare ..."; "Säravselge hommik. Linnupojad trügivad välja kolbast ..." = "Det var en glasklar morgon. Fågelungarna knuffas från skallen ..."; Armastuskiri = Kärleksbrev

  10. Model of the impact of parameters controlling replenishment in the bs (min-max continuous review system on the actual inventory availibility

    Directory of Open Access Journals (Sweden)

    Stanisław Krzyżaniak

    2015-09-01

    Full Text Available Background: Due to random changes in demand, inventory management is still - despite the development of alternative goods flow management concepts - an important issue both in terms of costs of maintenance and replenishment as well as the level of service measured by inventory availability levels. There are a number of replenishment systems to be used in such conditions, but they are most often formed on the basis of two basic ones: a system based on the reorder point and based on periodic inspection.  This paper refers to the former system, the BS system (min-max, in which an order is placed after reaching inventory level B (information level, reorder point for a quantity allowing to reach level S. This system is very often used in business practice. Observations conducted under realistic conditions indicate the need to improve the classical models describing the system.  This results, among other things, from the fact that the actual level of available inventory at the start of the replenishment cycle may be significantly lower than level B, resulting in lower than expected levels of customer service. Taking account of this phenomenon through model determination of the cumulative distribution function for the observed difference makes it possible to select the correct parameters to control the replenishment system in question and - therefore - to achieve the expected economic effects. Methods: The object of the study is to create a mathematical model allowing the determination of the required inventory level B taking into account the difference D between this level and the actual level of inventory at the start of the replenishment cycle.  To determine the effect of various factors such as demand distribution parameters in the adopted unit of time and the difference between level S (max and B (min, a dedicated tool (simulator in EXCEL spreadsheet for determining the distribution of frequency of value D has been developed.  Then a

  11. Motivational interviewing for screening and feedback and encouraging lifestyle changes to reduce relative weight in 4-8 year old children: design of the MInT study

    Directory of Open Access Journals (Sweden)

    Taylor Barry J

    2010-05-01

    Full Text Available Abstract Background Because parental recognition of overweight in young children is poor, we need to determine how best to inform parents that their child is overweight in a way that enhances their acceptance and supports motivation for positive change. This study will assess 1 whether weight feedback delivered using motivational interviewing increases parental acceptance of their child's weight status and enhances motivation for behaviour change, and 2 whether a family-based individualised lifestyle intervention, delivered primarily by a MInT mentor with limited support from "expert" consultants in psychology, nutrition and physical activity, can improve weight outcomes after 12 and 24 months in young overweight children, compared with usual care. Methods/Design 1500 children aged 4-8 years will be screened for overweight (height, weight, waist, blood pressure, body composition. Parents will complete questionnaires on feeding practices, physical activity, diet, parenting, motivation for healthy lifestyles, and demographics. Parents of children classified as overweight (BMI ≥ CDC 85th will receive feedback about the results using Motivational interviewing or Usual care. Parental responses to feedback will be assessed two weeks later and participants will be invited into the intervention. Additional baseline measurements (accelerometry, diet, quality of life, child behaviour will be collected and families will be randomised to Tailored package or Usual care. Parents in the Usual care condition will meet once with an advisor who will offer general advice regarding healthy eating and activity. Parents in the Tailored package condition will attend a single session with an "expert team" (MInT mentor, dietitian, physical activity advisor, clinical psychologist to identify current challenges for the family, develop tailored goals for change, and plan behavioural strategies that best suit each family. The mentor will continue to provide support to the

  12. Motivational interviewing for screening and feedback and encouraging lifestyle changes to reduce relative weight in 4-8 year old children: design of the MInT study.

    Science.gov (United States)

    Taylor, Rachael W; Brown, Deirdre; Dawson, Anna M; Haszard, Jill; Cox, Adell; Rose, Elaine A; Taylor, Barry J; Meredith-Jones, Kim; Treacy, Lee; Ross, Jim; William, Sheila M

    2010-05-24

    Because parental recognition of overweight in young children is poor, we need to determine how best to inform parents that their child is overweight in a way that enhances their acceptance and supports motivation for positive change. This study will assess 1) whether weight feedback delivered using motivational interviewing increases parental acceptance of their child's weight status and enhances motivation for behaviour change, and 2) whether a family-based individualised lifestyle intervention, delivered primarily by a MInT mentor with limited support from "expert" consultants in psychology, nutrition and physical activity, can improve weight outcomes after 12 and 24 months in young overweight children, compared with usual care. 1500 children aged 4-8 years will be screened for overweight (height, weight, waist, blood pressure, body composition). Parents will complete questionnaires on feeding practices, physical activity, diet, parenting, motivation for healthy lifestyles, and demographics. Parents of children classified as overweight (BMI > or = CDC 85th) will receive feedback about the results using Motivational interviewing or Usual care. Parental responses to feedback will be assessed two weeks later and participants will be invited into the intervention. Additional baseline measurements (accelerometry, diet, quality of life, child behaviour) will be collected and families will be randomised to Tailored package or Usual care. Parents in the Usual care condition will meet once with an advisor who will offer general advice regarding healthy eating and activity. Parents in the Tailored package condition will attend a single session with an "expert team" (MInT mentor, dietitian, physical activity advisor, clinical psychologist) to identify current challenges for the family, develop tailored goals for change, and plan behavioural strategies that best suit each family. The mentor will continue to provide support to the family via telephone and in

  13. Inhibition of intestinal adenoma formation in APC(Min/+ mice by Riccardin D, a natural product derived from liverwort plant Dumortiera hirsuta.

    Directory of Open Access Journals (Sweden)

    Hui-Ping Liu

    Full Text Available BACKGROUND: Mutation of tumor suppressor gene, adenomatous polyposis coli (APC, is the primary molecular event in the development of most intestinal carcinomas. Animal model with APC gene mutation is an effective tool for study of preventive approaches against intestinal carcinomas. We aimed to evaluate the effect of Riccardin D, a macrocyclic bisbibenzyl compound, as a chemopreventive agent against intestinal adenoma formation in APC(Min/+ mice. METHODS: APC(Min/+ mice were given Riccardin D by p.o. gavage for 7 weeks. Mice were sacrificed, and the number, size and histopathology of intestinal polyps were examined under a microscope. We performed immunohistochemical staining, western blotting, reverse transcriptase-polymerase chain reaction (RT-PCR and enzyme-linked immunosorbent assay (ELISA in intestinal polyps to investigate the mechanism of chemopreventive effect of Riccardin D. RESULTS: Riccardin D treatment resulted in a significant inhibition of intestinal adenoma formation, showing a reduction of polyp number by 41.7%, 31.1% and 44.4%, respectively, in proximal, middle and distal portions of small intestine. The activity of Riccardin D against polyp formation was more profound in colon, wherein Riccardin D decreased polyp number by 79.3%. Size distribution analysis revealed a significant reduction in large-size polyps (2-3 mm by 40.0%, 42.5% and 33.3%, respectively, in proximal, middle and distal portions of small intestine, and 77.8% in colon. Histopathological analysis of the intestinal polyps revealed mostly hyperplastic morphology without obvious dysplasia in Riccardin D-treated mice. Molecular analyses of the polyps suggested that the inhibitory effect of Riccardin D on intestinal adenoma formation was associated with its abilities of reduction in cell proliferation, induction of apoptosis, antiangiogenesis, inhibition of the Wnt signaling pathway and suppression of inflammatory mediators in polyps. CONCLUSIONS: Our results

  14. The CheMin XRD on the Mars Science Laboratory Rover Curiosity: Construction, Operation, and Quantitative Mineralogical Results from the Surface of Mars

    Science.gov (United States)

    Blake, David F.

    2015-01-01

    The Mars Science Laboratory mission was launched from Cape Canaveral, Florida on Nov. 26, 2011 and landed in Gale crater, Mars on Aug. 6, 2012. MSL's mission is to identify and characterize ancient "habitable" environments on Mars. MSL's precision landing system placed the Curiosity rover within 2 km of the center of its 20 X 6 km landing ellipse, next to Gale's central mound, a 5,000 meter high pile of laminated sediment which may contain 1 billion years of Mars history. Curiosity carries with it a full suite of analytical instruments, including the CheMin X-ray diffractometer, the first XRD flown in space. CheMin is essentially a transmission X-ray pinhole camera. A fine-focus Co source and collimator transmits a 50µm beam through a powdered sample held between X-ray transparent plastic windows. The sample holder is shaken by a piezoelectric actuator such that the powder flows like a liquid, each grain passing in random orientation through the beam over time. Forward-diffracted and fluoresced X-ray photons from the sample are detected by an X-ray sensitive Charge Coupled Device (CCD) operated in single photon counting mode. When operated in this way, both the x,y position and the energy of each photon are detected. The resulting energy-selected Co Kalpha Debye-Scherrer pattern is used to determine the identities and amounts of minerals present via Rietveld refinement, and a histogram of all X-ray events constitutes an X-ray fluorescence analysis of the sample.The key role that definitive mineralogy plays in understanding the Martian surface is a consequence of the fact that minerals are thermodynamic phases, having known and specific ranges of temperature, pressure and composition within which they are stable. More than simple compositional analysis, definitive mineralogical analysis can provide information about pressure/temperature conditions of formation, past climate, water activity and the like. Definitive mineralogical analyses are necessary to establish

  15. Derivation and Error Analysis of the Earth Magnetic Anomaly Grid at 2 arc min Resolution Version 3 (EMAG2v3)

    Science.gov (United States)

    Meyer, B.; Chulliat, A.; Saltus, R.

    2017-12-01

    The Earth Magnetic Anomaly Grid at 2 arc min resolution version 3, EMAG2v3, combines marine and airborne trackline observations, satellite data, and magnetic observatory data to map the location, intensity, and extent of lithospheric magnetic anomalies. EMAG2v3 includes over 50 million new data points added to NCEI's Geophysical Database System (GEODAS) in recent years. The new grid relies only on observed data, and does not utilize a priori geologic structure or ocean-age information. Comparing this grid to other global magnetic anomaly compilations (e.g., EMAG2 and WDMAM), we can see that the inclusion of a priori ocean-age patterns forces an artificial linear pattern to the grid; the data-only approach allows for greater complexity in representing the evolution along oceanic spreading ridges and continental margins. EMAG2v3 also makes use of the satellite-derived lithospheric field model MF7 in order to accurately represent anomalies with wavelengths greater than 300 km and to create smooth grid merging boundaries. The heterogeneous distribution of errors in the observations used in compiling the EMAG2v3 was explored, and is reported in the final distributed grid. This grid is delivered at both 4 km continuous altitude above WGS84, as well as at sea level for all oceanic and coastal regions.

  16. Analysis and stochastic modelling of Intensity-Duration-Frequency relationship from 88 years of 10 min rainfall data in North Spain

    Science.gov (United States)

    Delgado, Oihane; Campo-Bescós, Miguel A.; López, J. Javier

    2017-04-01

    Frequently, when we are trying to solve certain hydrological engineering problems, it is often necessary to know rain intensity values related to a specific probability or return period, T. Based on analyses of extreme rainfall events at different time scale aggregation, we can deduce the relationships among Intensity-Duration-Frequency (IDF), that are widely used in hydraulic infrastructure design. However, the lack of long time series of rainfall intensities for smaller time periods, minutes or hours, leads to use mathematical expressions to characterize and extend these curves. One way to deduce them is through the development of synthetic rainfall time series generated from stochastic models, which is evaluated in this work. From recorded accumulated rainfall time series every 10 min in the pluviograph of Igueldo (San Sebastian, Spain) for the time period between 1927-2005, their homogeneity has been checked and possible statistically significant increasing or decreasing trends have also been shown. Subsequently, two models have been calibrated: Bartlett-Lewis and Markov chains models, which are based on the successions of storms, composed for a series of rainfall events, separated by a short interval of time each. Finally, synthetic ten-minute rainfall time series are generated, which allow to estimate detailed IDF curves and compare them with the estimated IDF based on the recorded data.

  17. MIN 14C UBT: A combination of gastric basal transit and 14C-urea breath test for the detection of helicobacter pylori infection in human beings

    International Nuclear Information System (INIS)

    Zubillaga, M.; Oliveri, P.; Calcagno, M.L.; Goldman, C.; Caro, R.; Mitta, A.; Degrossi, O.; Boccio, J.

    1997-01-01

    The purpose of this work is to demonstrate that the 14 C-urea breath test (UBT) performed at different times combined with the study of the gastric basal transit, which evaluates the intragastric displacement of a labeled solution under fasting conditions, has the advantage of being representative of the whole stomach surface and constitutes a non-aggressive test for the detection of H. pylori. This test, which has been called MIN 14 C UBT, is a modification of the conventional 14 C UBT in which low volumes of a solution of 14 C-urea together with 99m Tc-sulfur colloid are administered. The 99m Tc-sulfur colloid is not absorbed in the gastrointestinal tract and has the great advantage of allowing the 'visualization' of the transit of the 14 C-urea within the gastrointestinal tract. This modification allows the simultaneous determination of the production of the 14 CO 2 and the place where this process occurs. The results show that there is a good correlation between the images obtained and the breath samples collected. We found that this test has a sensitivity of 98% and a specificity of 96% for H. pylori detection

  18. Seasonal variations of nitrous oxide fluxes and soil denitrification rates in subtropical freshwater and brackish tidal marshes of the Min River estuary.

    Science.gov (United States)

    Wang, Xuming; Hu, Minjie; Ren, Hongchang; Li, Jiabing; Tong, Chuan; Musenze, Ronald S

    2018-03-01

    Estuarine tidal marshes provide favorable conditions for nitrous oxide (N 2 O) production. Saltwater intrusion caused by sea-level rise would exert complex effects on the production and emission of N 2 O in estuarine tidal marshes; however, few studies have been conducted on its effects on N 2 O emissions. Salinity gradients are a common occurrence in estuarine tidal marshes. Studies on production and emission of N 2 O in tidal marshes with different salinities may elucidate the impact of saltwater intrusion on the emission of greenhouse gases. This study explores the seasonal variations of N 2 O fluxes and soil denitrification rates in freshwater (Daoqingzhou wetland) and brackish (Shanyutan wetland) tidal marshes dominated by Cyperus malaccensis var. brevifolius (shichito matgrass) in the Min River estuary, southeastern China. N 2 O fluxes in both marshes showed strong temporal variability. The highest N 2 O fluxes were observed in the hot and wet summer months, whereas the lowest fluxes were observed in the cold winter and autumn months. N 2 O fluxes from the freshwater marsh (48.81±9.01μgm -2 h -1 ) were significantly higher (ptidal wetlands and exert a negative feedback on the climate system. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. Modification of the Ti40Cu36Zr10Pd14 BMG Crystallization Mechanism with Heating Rates 10-140 K/min

    Science.gov (United States)

    Czeppe, T.; Sypien, A.; Wierzbicka-Miernik, A.

    2016-12-01

    The article presents investigations of Ti40Cu36Zr10Pd14 bulk metallic glass crystallization process heated with the rates of 10, 60, 100 and 140 K/min. High heating rates experiments were performed in a new type of differential scanning calorimeter equipped with a fast responding thermal sensor. Phase composition and microstructure were studied with x-ray diffraction and transmission electron microscopy. The observed crystallization proceeded in two separate steps. Applied high rates of heating/cooling resulted in the crystallization of only one CuTi phase, replacing typical multi-phase crystallization. The microstructure after crystallization was polycrystalline with some amount of amorphous phase retained. Kinetic parameters were determined with the use of the Kissinger and Friedman iso-conversional analysis and Matusita-Sakka iso-kinetic model. The kinetic analysis supplies results concerning autocatalytically activated mechanism of primary crystallization with decreasing activation energy and small density of quenched-in nuclei, in good agreement with previous structural investigations. The mechanism of secondary crystallization required dense nuclei site, increasing activation energy and large nucleation frequency. The amorphous phase of Ti40Cu36Zr10Pd14 BMG revealed high thermal stability against crystallization. Application of high heating rates in DSC experiments might be useful for the determination of mechanism and kinetic parameters in investigations of metallic glasses crystallization, giving reasonable results.

  20. Long-term impact of pre-operative physical rehabilitation protocol on the 6-min walk test of patients with adolescent idiopathic scoliosis: A randomized clinical trial

    Directory of Open Access Journals (Sweden)

    V.L. dos Santos Alves

    2015-05-01

    Full Text Available Background: Monitored physical activities in patients with adolescent idiopathic scoliosis (AIS have been shown to improve physical performance, endurance and cardiopulmonary function and may be assessed by the 6-min walk test (6MWT. We aimed to evaluate the long-term results of the 6MWT after a rehabilitation protocol employed before surgical correction for AIS. Methods: This prospective randomized clinical trial studied the impact of a 4-month pre-operative physical rehabilitation protocol on post-operative cardiopulmonary function and physical endurance, by using the 6MWT, in patients with AIS submitted to surgical correction, comparing them to matched controls without physical rehabilitation. Studied variables were heart and respiratory rate, systolic and diastolic blood pressure, peripheral blood oxygen saturation, Borg score, and distance walked. Patients were assessed at baseline, after 4 months of rehabilitation, and 3, 6 and 12 months post-operatively. Results: A total of 50 patients with AIS were included in the study and allocated blindly, by simple randomization, into either one of the two groups, with 25 patients each: study group (pre-operative physical rehabilitation and control group. The physical rehabilitation protocol promoted significant progressive improvement in heart and respiratory rate, peripheral blood oxygen saturation, distance walked, and level of effort assessed by the Borg scale after surgery. Conclusions: Post-surgical recovery, evaluated by 6MWT, was significantly better in patients who underwent a 4-month pre-operative physical rehabilitation protocol. Keywords: Scoliosis, Exercise, Exercise movement techniques, Exercise therapy, Exercise test

  1. Application of the Min-Projection and the Model Predictive Strategies for Current Control of Three-Phase Grid-Connected Converters: a Comparative Study

    Directory of Open Access Journals (Sweden)

    M. Oloumi

    2015-06-01

    Full Text Available This paper provides a detailed comparative study concerning the performance of min-projection strategy (MPS and model predictive control (MPC systems to control the three-phase grid connected converters. To do so, first, the converter is modeled as a switched linear system. Then, the feasibility of the MPS technique is investigated and its stability criterion is derived as a lower limit on the DC link voltage. Next, the fundamental equations of the MPS to control a VSC are obtained in the stationary reference frame. The mathematical analysis reveals that the MPS is independent of the load, grid, filter and converter parameters. This feature is a great advantage of MPS over the MPC approach. However, the latter is a well-known model-based control technique, has already developed for controlling the VSC in the stationary reference frame. To control the grid connected VSC, both MPS and MPC approaches are simulated in the PSCAD/EMTDC environment. Simulation results illustrate that the MPS is functioning well and is less sensitive to grid and filter inductances as well as the DC link voltage level. However, the MPC approach renders slightly a better performance in the steady state conditions.

  2. Assessing of landscape potential for water management regarding its surface water (using the example of the micro-region Minčol

    Directory of Open Access Journals (Sweden)

    Kunáková Lucia

    2016-06-01

    Full Text Available The presence of water is one of the decisive factors of landscape’s natural potential. Water affects landscape’s predisposition for agricultural production, water supply available to the wide population and industry (the most important is the yield of water resources. Ponds, lakes and other water areas are zones of recreation and relaxation. Near sources mineral water, several world-famous spas were build. Waterways are also used to generate electricity. Geothermal underground water represents a very significant landscape potential. Determining hydrological potential of the area is important for the regional development. This paper assesses the landscape potential for water management regarding its surface waters in the micro-region Minčol. The micro-region was divided by a square grid, and for each square, we determined the appropriateness of this potential based on score points. The determining evaluation criteria were static reserves of surface water, waterway ranking and annual average discharge. First, we determined the significance (value of individual criteria (classification characteristics, and then we calculated the values of individual classifiers, which were then multiplied by the value of the individual classifier intervals. The summary of points in each square belongs to a particular degree of suitability for water management based on surface waters. The potential was divided into five degrees (intervals: very unfavourable potential, unfavourable potential, moderately favourable potential, favourable potential and very favourable potential.

  3. Mineralogy, provenance, and diagenesis of a potassic basaltic sandstone on Mars: CheMin X-ray diffraction of the Windjana sample (Kimberley area, Gale Crater)

    International Nuclear Information System (INIS)

    Treiman, Allan H.; Bish, David L.; Chipera, Steve J.; Blake, David F.

    2015-01-01

    The Windjana drill sample, a sandstone of the Dillinger member (Kimberley formation, Gale Crater, Mars), was analyzed by CheMin X-ray diffraction (XRD) in the MSL Curiosity rover. From Rietveld refinements of its XRD pattern, Windjana contains the following: sanidine (21% weight, ~Or 95 ); augite (20%); magnetite (12%); pigeonite; olivine; plagioclase; amorphous and smectitic material (~25%); and percent levels of others including ilmenite, fluorapatite, and bassanite. From mass balance on the Alpha Proton X-ray Spectrometer (APXS) chemical analysis, the amorphous material is Fe rich with nearly no other cations—like ferrihydrite. The Windjana sample shows little alteration and was likely cemented by its magnetite and ferrihydrite. From ChemCam Laser-Induced Breakdown Spectrometer (LIBS) chemical analyses, Windjana is representative of the Dillinger and Mount Remarkable members of the Kimberley formation. LIBS data suggest that the Kimberley sediments include at least three chemical components. The most K-rich targets have 5.6% K 2 O, ~1.8 times that of Windjana, implying a sediment component with >40% sanidine, e.g., a trachyte. A second component is rich in mafic minerals, with little feldspar (like a shergottite). A third component is richer in plagioclase and in Na 2 O, and is likely to be basaltic. The K-rich sediment component is consistent with APXS and ChemCam observations of K-rich rocks elsewhere in Gale Crater. The source of this sediment component was likely volcanic. Finally, the presence of sediment from many igneous sources, in concert with Curiosity's identifications of other igneous materials (e.g., mugearite), implies that the northern rim of Gale Crater exposes a diverse igneous complex, at least as diverse as that found in similar-age terranes on Earth.

  4. Tissue Fatty Acid Profile is Differently Modulated from Olive Oil and Omega-3 Polyunsaturated Fatty Acids in ApcMin/+ Mice.

    Science.gov (United States)

    Tutino, Valeria; Caruso, Maria G; De Leonardis, Giampiero; De Nunzio, Valentina; Notarnicola, Maria

    2017-11-16

    Fatty acid profile can be considered an appropriate biomarker for investigating the relations between the patterns of fatty acid metabolism and specific diseases, as cancer, cardiovascular and degenerative diseases. Aim of this study was to test the effects of diets enriched with olive oil and omega-3 Polyunsaturated Fatty Acids (PUFAs) on fatty acid profile in intestinal tissue of ApcMin/+ mice. Three groups of animals were considered: control group, receiving a standard diet; olive oilgroup, receiving a standard diet enriched with olive oil; omega-3 group, receiving a standard diet enriched with salmon fish. Tissue fatty acid profile was evaluated by gas chromatography method. Olive oil and omega-3 PUFAs in the diet differently affect the tissue fatty acid profile. Compared to control group, the levels of Saturated Fatty Acids (SFAs) were lower in olive oil group, while an increase of SFAs was found in omega-3 group. Monounsaturated Fatty Acids (MUFAs) levels were enhanced after olive oil treatment, and in particular, a significant increase of oleic acid levels was detected; MUFAs levels were instead reduced in omega-3 group in line with the decrease of oleic acid levels. The total PUFAs levels were lower in olive oil respect to control group. Moreover, a significant induction of Saturation Index (SI) levels was observed after omega-3 PUFAs treatment, while its levels were reduced in mice fed with olive oil. Our data demonstrated a different effect of olive oil and omega-3 PUFAs on tissue lipid profile in APCMin/+ mice. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  5. A novel liquid chromatography/tandem mass spectrometry method for the quantification of glycine as biomarker in brain microdialysis and cerebrospinal fluid samples within 5min.

    Science.gov (United States)

    Voehringer, Patrizia; Fuertig, René; Ferger, Boris

    2013-11-15

    Glycine is an important amino acid neurotransmitter in the central nervous system (CNS) and a useful biomarker to indicate biological activity of drugs such as glycine reuptake inhibitors (GRI) in the brain. Here, we report how a liquid chromatography/tandem mass spectrometry (LC-MS/MS) method for the fast and reliable analysis of glycine in brain microdialysates and cerebrospinal fluid (CSF) samples has been established. Additionally, we compare this method with the conventional approach of high performance liquid chromatography (HPLC) coupled to fluorescence detection (FD). The present LC-MS/MS method did not require any derivatisation step. Fifteen microliters of sample were injected for analysis. Glycine was detected by a triple quadrupole mass spectrometer in the positive electrospray ionisation (ESI) mode. The total running time was 5min. The limit of quantitation (LOQ) was determined as 100nM, while linearity was given in the range from 100nM to 100μM. In order to demonstrate the feasibility of the LC-MS/MS method, we measured glycine levels in striatal in vivo microdialysates and CSF of rats after administration of the commercially available glycine transporter 1 (GlyT1) inhibitor LY 2365109 (10mg/kg, p.o.). LY 2365109 produced 2-fold and 3-fold elevated glycine concentrations from 1.52μM to 3.6μM in striatal microdialysates and from 10.38μM to 36μM in CSF, respectively. In conclusion, we established a fast and reliable LC-MS/MS method, which can be used for the quantification of glycine in brain microdialysis and CSF samples in biomarker studies. Copyright © 2013 Elsevier B.V. All rights reserved.

  6. Correlation of 6-min walk test with left ventricular function and quality of life in heart failure due to Chagas disease.

    Science.gov (United States)

    Chambela, Mayara C; Mediano, Mauro F F; Ferreira, Roberto R; Japiassú, André M; Waghabi, Mariana C; da Silva, Gilberto M S; Saraiva, Roberto M

    2017-10-01

    To evaluate the correlation of the total distance walked during the six-minute walk test (6MWT) with left ventricular function and quality of life in patients with Chagas Disease (ChD) complicated by heart failure. This is a cross-sectional study of adult patients with ChD and heart failure diagnosed based on Framingham criteria. 6MWT was performed following international guidelines. New York Heart Association functional class, brain natriuretic peptide (BNP) serum levels, echocardiographic parameters and quality of life (SF-36 and MLHFQ questionnaires) were determined and their correlation with the distance covered at the 6MWT was tested. Forty adult patients (19 male; 60 ± 12 years old) with ChD and heart failure were included in this study. The mean left ventricular ejection fraction was 35 ± 12%. Only two patients (5%) ceased walking before 6 min had elapsed. There were no cardiac events during the test. The average distance covered was 337 ± 105 metres. The distance covered presented a negative correlation with BNP (r = -0.37; P = 0.02), MLHFQ quality-of-life score (r = -0.54; P = 0.002), pulmonary artery systolic pressure (r = -0.42; P = 0.02) and the degree of diastolic dysfunction (r = -0.36; P = 0.03) and mitral regurgitation (r = -0.53; P = 0.0006) and positive correlation with several domains of the SF-36 questionnaire. The distance walked during the 6MWT correlates with BNP, quality of life and parameters of left ventricular diastolic function in ChD patients with heart failure. We propose this test to be adopted in endemic areas with limited resources to aid in the identification of patients who need referral for tertiary centres for further evaluation and treatment. © 2017 John Wiley & Sons Ltd.

  7. Transient Fanconi syndrome with severe polyuria and polydipsia in a 4-year old Shih Tzu fed chicken jerky treats.

    Science.gov (United States)

    Major, A; Schweighauser, A; Hinden, S E; Francey, T

    2014-12-01

    Acquired Fanconi syndrome is characterized by inappropriate urinary loss of amino acids, bicarbonate, electrolytes, and water. It has recently been described in dogs fed chicken jerky treats from China, a new differential diagnosis to the classical inciting infectious diseases (e.g. leptospirosis, pyelonephritis) and toxins. A dog fed exclusively chicken jerky treats purchased in Switzerland was presented to our clinic with severe polyuria, polydipsia and profound electrolyte and acid base disturbances. Other inciting causes of Fanconi syndrome were ruled out. The requirement of a very intensive supportive treatment in this dog stands in contrast to treatment of chronic forms of Fanconi syndrome as described in the Basenji. This intensive therapy and the associated monitoring can be a real challenge and a limiting factor for the prognosis of acquired Fanconi syndrome. Veterinarians should be aware of the risk of excessive feeding of chicken jerky treats.

  8. Chinese strategic culture, Shih and Li: a comparison of the Kuomintang and Chinese Communist Party from 1923-1927

    Science.gov (United States)

    2016-05-26

    contended that a time comes when “society can no longer live under this bourgeoisie , in other words, its existence is no longer compatible with society...said, “The first stage of revolution is the restriction of absolutism, which satisfies the bourgeoisie ; the second is the attainment of the republic...which satisfies the “people,” the peasantry and the petty bourgeoisie at large; the third is the socialist revolution, which alone can satisfy the

  9. Characterization of Two Multidrug-Resistant IncA/C Plasmids from the 1960s by Using the MinION Sequencer Device.

    Science.gov (United States)

    Szabó, Mónika; Nagy, Tibor; Wilk, Tímea; Farkas, Tibor; Hegyi, Anna; Olasz, Ferenc; Kiss, János

    2016-11-01

    Two A/C incompatibility group (IncA/C family) plasmids from the 1960s have been sequenced and classified into the A/C 2 type 1 group. R16a and IP40a contain novel antibiotic resistance islands and a complete GIsul2 genomic island not previously found in the family. In the 173.1-kb R16a, the 29.9-kb antibiotic resistance island (ARI) is located in a unique backbone position not utilized by ARIs. ARI R16a consists of Tn1, Tn6020, and Tn6333, harboring the resistance genes bla TEM-1D and aphA1b and a mer module, respectively; a truncated Tn5393 copy; and a gene cluster with unknown function. Plasmid IP40a is 170.4 kb in size and contains a 5.6-kb ARI inserted into the kfrA gene. ARI IP40a carrying bla TEM-1D and aphA1b genes is composed of Tn1 with a Tn6023 insertion. Additionally, IP40a harbors single IS2, IS186, and Tn1000 insertions scattered in the backbone; an IS150 copy in GIsul2; and a complete Tn6333 carrying a mer module at the position of ARI R16a Loss of resistance markers in R16a, IP40a, and R55 was observed during stability tests. Every phenotypic change proved to be the result of recombination events involving mobile elements. Intramolecular transposition of IS copies that generated IP40a derivatives lacking large parts of the backbone could account for the formation of other family members, too. The MinION platform proved to be a valuable tool in bacterial genome sequencing since it generates long reads that span repetitive elements and facilitates full-length plasmid or chromosome assembly. Nanopore technology enables rapid characterization of large, low-copy-number plasmids and their rearrangement products. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  10. Association between pretreatment retention rate of indocyanine green 15 min after administration and life prognosis in patients with HCC treated by proton beam therapy

    International Nuclear Information System (INIS)

    Mizumoto, Masashi; Oshiro, Yoshiko; Okumura, Toshiyuki; Fukuda, Kuniaki; Fukumitsu, Nobuyoshi; Abei, Masato; Ishikawa, Hitoshi; Ohnishi, Kayoko; Numajiri, Haruko; Tsuboi, Koji; Sakurai, Hideyuki

    2014-01-01

    Purpose: The Child-Pugh score is often used to judge the outcome of radiotherapy for hepatocellular carcinoma (HCC). The retention rate of indocyanine green 15 min after administration (ICG R15) can also be used to predict prognosis after liver resection. We evaluated the utility of ICG R15 for prediction of outcomes after proton beam therapy (PBT) for HCC. Methods and materials: A retrospective evaluation was performed in 250 patients who received PBT between 2002 and 2007. The patients (178 males and 72 females) had a median age of 71 years (range: 43–88). Child-Pugh categories were A (score 5–6), B (7–9), and C (10–15) in 197, 51, and 2 patients, respectively. ICG scores were 0–<10, 10–<20, 20–<30, 30–<40 and ⩾40 in 27, 99, 59, 28 and 37 patients, respectively; including 26, 92, 45, 16 and 18 Child-Pugh A patients and 1, 8, 14, 11, and 17 Child-Pugh B patients, respectively. Survival times from the start of PBT were compared between Child-Pugh A and B patients, and among each ICG group. Results: The median survival times were 61 months (95% CI: 50–72 months) in all patients, and 64 and 20 months in Child-Pugh A and B patients, respectively (p = 0.001), The 3-year survival rates were 72%, 72%, 75%, 63%, and 26% in patients with ICG scores of 0–<10, 10–<20, 20–<30, 30–<40, and ⩾40 (p = 0.001); 70%, 75%, 77%, 65%, and 38% in these respective groups in Child-Pugh A patients (p = 0.02); and 100%, 57%, 67%, 36%, and 14% in Child-Pugh B patients (p = 0.173, not significant). Multivariate analysis showed that low ICG R15 and the absence of portal vein tumor thrombus were associated with good survival. Conclusions: Pretreatment ICG R15 is a useful prognostic factor for prediction of outcome of PBT in HCC patients, especially in those with Child-Pugh A liver function

  11. Beat Tracking Based on Max-Min Distance Means%基于最大最小距离法的节拍跟踪

    Institute of Scientific and Technical Information of China (English)

    李锵; 何凝; 关欣

    2015-01-01

    将端点检测与聚类算法结合,提出一种基于最大最小距离法的节拍跟踪算法.首先,将音乐信号分解成多个频率互不重叠的子带进行频谱分析,分别利用半波整流,求和得到最终的端点强度曲线.其后,根据能量谱找到起始节拍点.最后,根据最大最小距离法并利用音乐速度与节拍的关系,对端点强度曲线峰值进行有效聚类,识别出节拍点.实验结果表明,该算法识别节拍点准确有效,4评估指标 P-score、Cemgil、CMLc 和 AMLt 分别达到57.355,10、38.705,37、17.152,40和47.259,12,与其他算法相比综合性能较好.%In this paper,combining onset detection and clustering algorithm,a novelbeat tracking algorithm based on max-min distance(MMD) means was proposed. First,the spectrum of music signal was decomposed into several non-overlapping sub-bands. Second,by utilizing the half-wave rectifier on these sub-bands respectively,the final onset strength curve was found. Then,the first beat was discovered based on the energy spectrum of the starting point. Finally,based on MMDmeans,the beats of the music signal were identified according to the relationship between music tempo and beat,together with effective clustering of curve peaks of onset strength. Experimental re-sults proved that the proposed algorithm can track beats accurately. The four evaluation indicators of the algorithm P-score,Cemgil,CMLc and AMLt,reached 57.355,10,38.705,37,17.152,40 and 47.259,12,respectively. Com-pared with other algorithms,the proposed algorithm possesses better comprehensive performance.

  12. Minęło już pół wieku... Powstanie i działalność Wydawnictwa Naukowego UAM

    Directory of Open Access Journals (Sweden)

    Iwona Wegner-Maruszewska

    2012-01-01

    Full Text Available W roku 2012 Wydawnictwo Naukowe UAM obchodzi 50-lecie istnienia – działa od roku 1962 jako jednostka ogólnouczelniana Uniwersytetu im. Adama Mickiewicza w Poznaniu. Publikuje przede wszystkim monografie naukowe (w 50 seriach tematycznych, podręczniki, skrypty, słowniki, a także 25 czasopism naukowych (również w językach obcych. Rocznie ukazuje się około 150 tytułów. Za swoje osiągnięcia edytorskie wielokrotnie otrzymywaliśmy nagrody, m.in. na Krajowych Targach Książki Akademickiej ATENA, Wrocławskich Targach Książki Naukowej, Nagrody Klio na Targach Książki Historycznej, nagrody Stowarzyszenia Wydawców Szkół Wyższych im. ks. Edwarda Pudełki za najlepszy podręcznik akademicki oraz dyplomy i wyróżnienia w kolejnych edycjach Poznańskiego Przeglądu Nowości Wydawniczych, organizowanego przez Bibliotekę Raczyńskich. Nasze książki prezentowane były na międzynarodowych wystawach polskiej książki naukowej organizowanych przez Stowarzyszenie Wydawców Szkół Wyższych w: Paryżu, Londynie, Lwowie, Rzymie, Sztokholmie, Wilnie, Pradze, Kijowie, Petersburgu, Dniepropietrowsku, Watykanie, Wiedniu, Madrycie, a także na międzynarodowych targach książki we Frankfurcie, Londynie, Moskwie, Zagrzebiu, Győr (Węgry i Pekinie. Wydawnictwo Naukowe UAM jest pomysłodawcą i głównym organizatorem Poznańskich Dni Książki Naukowej, odbywających się nieprzerwanie od 1997 roku i gromadzących wydawców z całej Polski. Miejscem corocznych targów książki jest Hol Wielki Collegium Maius. Wydawnictwo jest jednym z członków założycieli Stowarzyszenia Wydawców Szkół Wyższych oraz członkiem Polskiego Towarzystwa Wydawców Książek.

  13. Když cenzura produkuje: Na příkladu Zakázaných próz Vladimíra Mináče

    Czech Academy of Sciences Publication Activity Database

    Šámal, Petr

    2016-01-01

    Roč. 63, č. 6 (2016), s. 479-484 ISSN 0037-6973 Institutional support: RVO:68378068 Keywords : censorship * Mináč, Vladimír * fetishism * new censorship Subject RIV: AJ - Letters, Mass-media, Audiovision

  14. Comparative performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study equations for estimating GFR levels above 60 mL/min/1.73 m2.

    Science.gov (United States)

    Stevens, Lesley A; Schmid, Christopher H; Greene, Tom; Zhang, Yaping Lucy; Beck, Gerald J; Froissart, Marc; Hamm, Lee L; Lewis, Julia B; Mauer, Michael; Navis, Gerjan J; Steffes, Michael W; Eggers, Paul W; Coresh, Josef; Levey, Andrew S

    2010-09-01

    The Modification of Diet in Renal Disease (MDRD) Study equation underestimates measured glomerular filtration rate (GFR) at levels>60 mL/min/1.73 m2, with variable accuracy among subgroups; consequently, estimated GFR (eGFR)>or=60 mL/min/1.73 m2 is not reported by clinical laboratories. Here, performance of a more accurate GFR-estimating equation, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, is reported by level of GFR and clinical characteristics. Test of diagnostic accuracy. Pooled data set of 3,896 people from 16 studies with measured GFR (not used for the development of either equation). Subgroups were defined by eGFR, age, sex, race, diabetes, prior solid-organ transplant, and body mass index. eGFR from the CKD-EPI and MDRD Study equations and standardized serum creatinine. Measured GFR using urinary or plasma clearance of exogenous filtration markers. Mean measured GFR was 68+/-36 (SD) mL/min/1.73 m2. For eGFR73 m2, both equations have similar bias (median difference compared with measured GFR). For eGFR of 30-59 mL/min/1.73 m2, bias was decreased from 4.9 to 2.1 mL/min/1.73 m2 (57% improvement). For eGFR of 60-89 mL/min/1.73 m2, bias was decreased from 11.9 to 4.2 mL/min/1.73 m2 (61% improvement). For eGFR of 90-119 mL/min/1.73 m2, bias was decreased from 10.0 to 1.9 mL/min/1.73 m2 (75% improvement). Similar or improved performance was noted for most subgroups with eGFR73 m2, other than body mass indexor=90 mL/min/1.73 m2. Limited number of elderly people and racial and ethnic minorities with measured GFR. The CKD-EPI equation is more accurate than the MDRD Study equation overall and across most subgroups. In contrast to the MDRD Study equation, eGFR>or=60 mL/min/1.73 m2 can be reported using the CKD-EPI equation. Copyright (c) 2010 National Kidney Foundation, Inc. All rights reserved.

  15. Análise das velocidades: referencial de 4mM, de equilíbrio de 30 min e velocidade crítica em nadadoras adolescentes Velocities analysis: 4 mM reference, 30 min steady-state and critical velocity in female adolescent swimmers

    Directory of Open Access Journals (Sweden)

    Emilson Colantonio

    2007-12-01

    Full Text Available OBJETIVO: Comparar os resultados do cálculo da velocidade de limiar anaeróbio (Lan, correspondente a 4mM de lactato, obtidos em testes de 2 x 400m (V4-2, 4 x 400m (V4-4 e a velocidade crítica (VC relacionando-as com a velocidade média determinada no teste de 30 min (VMT30 em nadadoras adolescentes. METODOLOGIA: Participaram deste estudo 20 nadadoras (14,36 ± 1,22 anos; 52,75 ± 5,32kg; 159,97 ± 11,26cm; 22,5 ± 4,73% gordura corporal de nível regional e estadual com pelo menos dois anos de treinamento sistemático. Testes realizados: Teste de 30 min (VMT30, Teste de duas distâncias (V4-2, Teste de quatro distâncias (V4-4 e Velocidade Crítica (VC. Análise estatística: o procedimento adotado para a comparação de todas as metodologias, duas a duas, foi a técnica de análise de regressão simples. RESULTADOS: As velocidades médias dos testes foram: VMT30: 1,12 ± 0,06m/s; V4-2: 1,14 ± 0,12m/s; V4-4: 1,12 ± 0,06m/s e a VC média: 1,14 ± 0,07m/s. Análise de regressão simples entre as metodologias duas a duas: V4-4 e V4-2 (r = 0,324, VC e V4-2 (r = 0,058, VMT30 e V4-2 (r = 0,595, VC e V4-4 (r = 0,807, VMT30 e V4-4 (r = 0,796 e VMT30 e VC (r = 0,677. As retas de regressão ajustadas apresentaram em relação à bissetriz os valores de p = 0,3060; 0,1716 e 0,0058. CONCLUSÕES: A determinação da VMT30 constitui-se em um bom instrumento para a prescrição de treinamento para as nadadoras estudadas, o que nem sempre ocorre com o modelo V4-2; a [La] de 4mM com quatro pontos e o cálculo do limiar de lactato através da técnica de efeitos aleatórios, mostrou-se viável para a determinação do Lan para as nadadoras, quando comparada com a VMT30; a VC e V4-4 apresentaram boa correlação assim como a VC e VMT30.OBJECTIVE: To compare the results of the calculation of the anaerobic threshold velocity (AT, corresponding to 4 mM lactate, obtained in 2 x 400 m (V4-2, 4 x 400 m (V4-4 tests and critical velocity (CV relating to the mean

  16. Efficacy and Safety of MIN-101: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial of a New Drug in Development for the Treatment of Negative Symptoms in Schizophrenia.

    Science.gov (United States)

    Davidson, Michael; Saoud, Jay; Staner, Corinne; Noel, Nadine; Luthringer, Elisabeth; Werner, Sandra; Reilly, Joseph; Schaffhauser, Jean-Yves; Rabinowitz, Jonathan; Weiser, Mark; Luthringer, Remy

    2017-12-01

    The authors assessed the efficacy, safety, and tolerability of MIN-101, a compound with affinities for sigma-2 and 5-HT 2A receptors and no direct dopamine affinities, in comparison with placebo in treating negative symptoms in stabilized patients with schizophrenia. The trial enrolled 244 patients who had been symptomatically stable for at least 3 months and had scores of at least 20 on the negative subscale of the Positive and Negative Syndrome Scale (PANSS). After at least 5 days' withdrawal from all antipsychotic medication, patients were randomly assigned to receive placebo or 32 mg/day or 64 mg/day of MIN-101 for 12 weeks. The primary outcome measure was the PANSS negative factor score (pentagonal structure model). Secondary outcome measures were PANSS total score and scores on the Clinical Global Impressions Scale (CGI), the Brief Negative Symptom Scale, the Brief Assessment of Cognition in Schizophrenia, and the Calgary Depression Scale for Schizophrenia. A statistically significant difference in PANSS negative factor score was observed, with lower scores for the MIN-101 32 mg/day and 64 mg/day groups compared with the placebo group (effect sizes, d=0.45 and d=0.57, respectively). Supporting these findings were similar effects on several of the secondary outcome measures, such as the PANSS negative symptom, total, and activation factor scores, the CGI severity item, and the Brief Negative Symptom Scale. There were no statistically significant differences in PANSS positive scale score between the MIN-101 and placebo groups. No clinically significant changes were observed in vital signs, routine laboratory values, weight, metabolic indices, and Abnormal Involuntary Movement Scale score. MIN-101 demonstrated statistically significant efficacy in reducing negative symptoms and good tolerability in stable schizophrenia patients.

  17. Max–min distance nonnegative matrix factorization

    KAUST Repository

    Wang, Jim Jing-Yan; Gao, Xin

    2014-01-01

    Nonnegative Matrix Factorization (NMF) has been a popular representation method for pattern classification problems. It tries to decompose a nonnegative matrix of data samples as the product of a nonnegative basis matrix and a nonnegative coefficient matrix. The columns of the coefficient matrix can be used as new representations of these data samples. However, traditional NMF methods ignore class labels of the data samples. In this paper, we propose a novel supervised NMF algorithm to improve the discriminative ability of the new representation by using the class labels. Using the class labels, we separate all the data sample pairs into within-class pairs and between-class pairs. To improve the discriminative ability of the new NMF representations, we propose to minimize the maximum distance of the within-class pairs in the new NMF space, and meanwhile to maximize the minimum distance of the between-class pairs. With this criterion, we construct an objective function and optimize it with regard to basis and coefficient matrices, and slack variables alternatively, resulting in an iterative algorithm. The proposed algorithm is evaluated on three pattern classification problems and experiment results show that it outperforms the state-of-the-art supervised NMF methods.

  18. Min-Bias at the Tevatron

    International Nuclear Information System (INIS)

    Field, Rick

    2007-01-01

    As illustrated in Fig. 1, the total proton-antiproton cross section is the sum of the elastic and inelastic components, σ tot = σ EL + σ IN . The inelastic cross section consists of three terms; single diffraction, double-diffraction, and everything else (referred to as the 'hard core'), σ IN = σ SD + σ DD + σ HC . For elastic scattering neither of the beam particles breaks apart (i.e. color singlet exchange). For single and double diffraction one or both of the beam particles are excited into a high mass color singlet state (i.e. N* states) which then decays. Single and double diffraction also corresponds to color singlet exchange between the beam hadrons. When color is exchanged the outgoing remnants are no longer color singlets and one has a separation of color resulting in a multitude of quark-antiquark pairs being pulled out of the vacuum. The 'hard core' component, σ HC , involves color exchange and the separation of color. However, the 'hard core' contribution has both a 'soft' and 'hard' component. Most of the time the color exchange between partons in the beam hadrons occurs through a soft interaction (i.e. no high transverse momentum) and the two beam hadrons 'ooze' through each other producing lots of soft particles with a uniform distribution in rapidity and many particles flying down the beam pipe. Occasionally there is a hard scattering among the constituent partons producing outgoing particles and 'jets' with high transverse momentum

  19. sup(113m)In chelate complexes

    International Nuclear Information System (INIS)

    Abram, S.; Abram, U.; Spies, H.; Muenze, R.

    1985-01-01

    A series of 7 indiumdialkyldithiocarbamates (R=ethyl, n-propyl, i-propyl, n-butyl, i-butyl, -(CH 2 ) 5 -, -(CH 2 ) 2 -O-(CH 2 ) 2 -) has been prepared by reacting InCl 3 with aqueous solutions of the ligands. The products have been investigated at various concentration levels. The properties of the products at the lower concentration levels have been studied by thin-layer chromatography, electrophoresis and by determination of the octanol/water partition. A comparison of the results with the behaviour of the well-characterized tris(dialkyldithiocarbamato)indium(III) complexes is given. (author)

  20. Dersom Du, min Læser! ..

    DEFF Research Database (Denmark)

    Wille, Niels Erik

    2011-01-01

    Diskuterer problemer med anvendelse af sproghandlingsteori på illokutionære (især assertive) sproghandlinger i fiktionsfortællinger og andre tekster. Påviser at problemerne udspringer af uheldige eller ugennemtænkte formuleringer allerede i de første formuleringer af sproghandlingsteorien samt de...

  1. Min danske drøm

    DEFF Research Database (Denmark)

    Weirsøe, Mathilde

    2010-01-01

    Unge indvandrerkvinder stormer ind på gymnasierne og derfra videre til universiteterne. De unge kvinder er ikke bare mønsterelever, men også mønsterbrydere. Hvorfor når de så langt? Er det i virkeligheden noget helt andet end forældrenes uddannelse, arbejde og indkomst, der har betydning for...

  2. Max–min distance nonnegative matrix factorization

    KAUST Repository

    Wang, Jim Jing-Yan

    2014-10-26

    Nonnegative Matrix Factorization (NMF) has been a popular representation method for pattern classification problems. It tries to decompose a nonnegative matrix of data samples as the product of a nonnegative basis matrix and a nonnegative coefficient matrix. The columns of the coefficient matrix can be used as new representations of these data samples. However, traditional NMF methods ignore class labels of the data samples. In this paper, we propose a novel supervised NMF algorithm to improve the discriminative ability of the new representation by using the class labels. Using the class labels, we separate all the data sample pairs into within-class pairs and between-class pairs. To improve the discriminative ability of the new NMF representations, we propose to minimize the maximum distance of the within-class pairs in the new NMF space, and meanwhile to maximize the minimum distance of the between-class pairs. With this criterion, we construct an objective function and optimize it with regard to basis and coefficient matrices, and slack variables alternatively, resulting in an iterative algorithm. The proposed algorithm is evaluated on three pattern classification problems and experiment results show that it outperforms the state-of-the-art supervised NMF methods.

  3. Hvorfra min verden går

    DEFF Research Database (Denmark)

    Keiding, Tina Bering

    , herunder tematisering af spørgs-målet om, hvad der synes at udgøre centrale elementer i kommunikation, der har intentioner om at indvirke på og forandre andre systemer, samt spørgsmålet om, og i givet fald hvordan, lukkede systemer kan iagttage og forstå hinanden. I afhandlingens første del defineres de...... nødvendig dimension i den teoretiske didaktik, hvis uddannelse og undervisning skal kunne koble sig til didaktikkens temaer på en måde, der sandsynliggør, at der etableres en velfunge-rende strukturel kobling mellem didaktikkens intentioner og uddannelsessyste-mets forståelse af disse. Foreskrivende...... for iagttagelse af læring vil være formet af, hvilke medde-lelsesformer, der stilles til rådighed for iagttagelse af læring. Uddannelser og undervisning kan begge ses som systemer med intention om at indvirke på og forandre systemer i deres omverden. Iagttages uddannelse og un-dervisning ud fra forudsætningen om...

  4. Effect of maternal and post weaning folate supply on gene-specific DNA methylation in the small intestine of weaning and adult Apc+/Min and wild type mice.

    Directory of Open Access Journals (Sweden)

    Jill Ann Mckay

    2011-05-01

    Full Text Available Increasing evidence supports the developmental origins of adult health and disease hypothesis which argues for a causal relationship between adverse early life nutrition and increased disease risk in adulthood. Modulation of epigenetic marks, e.g. DNA methylation and consequential altered gene expression, has been proposed as a mechanism mediating these effects. Via its role as a methyl donor, dietary folate supply may influence DNA methylation. As aberrant methylation is an early event in colorectal cancer (CRC pathogenesis, we hypothesised low maternal and/or post-weaning folate intake may influence methylation of genes involved in CRC development. We investigated the effects of maternal folate depletion during pregnancy and lactation on selected gene methylation in the small intestine (SI of wild type (WT and Apc+/Min mice at weaning and as adults. We also investigated the effects of folate depletion post-weaning on gene methylation in adult mice. Female C57Bl6/J mice were fed low or normal folate diets from mating with Apc+/Min males to the end of lactation. A sub set of offspring were killed at weaning. Remaining offspring were weaned on to low or normal folate diets, resulting in 4 treatment groups of Apc+/Min and WT mice. p53 was more methylated in weaning and adult WT compared with Apc+/Min mice (p>0.001. Igf2 and Apc were hypermethylated in adult Apc+/Mi n compared with WT mice (p=0.004 & p=0.012 respectively. Low maternal folate reduced p53 methylation in adults (p=0.04. Low post-weaning folate increased Apc methylation in Apc+/Min mice only (p=0.008 for interaction. These observations demonstrate that folate depletion in early life can alter epigenetic marks in a gene specific manner. Also, the differential effects of altered folate supply on DNA methylation in WT and Apc+/Min mice suggest that genotype may modulate epigenetic responses to environmental cues and may have implications for the development of personalised nutrition.

  5. Evolution saisonnière des phosphates et des composés minéraux dissous de l'azote en lagune Aby (Côte d'Ivoire)

    OpenAIRE

    Métongo, B.S.

    1989-01-01

    Cette étude présente le cycle annuel des variations des orthophosphates (P-PO4) et des composés minéraux dissous de l'azote (N-NO3, N-N02 and N-NH4) dans la colonne d'eau de juillet 1984 à juillet 1985 en lagune Aby... Les valeurs maximales des sels nutritifs sont enregistrées en saison de pluies et de crues et leur distribution est fonction de la stratification physique des eaux

  6. Radioprotective effects of melanin-glucan complex from Fomes Fomentarius and indralin at irradiation of mice BALB/C by dose of 5,95 Gy/8,5 min

    Directory of Open Access Journals (Sweden)

    O. F. Seniuk

    2014-06-01

    Full Text Available Protective effect of melanin-glucan complex from F. fomentarius (MGC and Russian armed forces radiopro-tector indralin in the model of acute exposure by dose of 5.95 Gy/8.5min care is compared. Obtained results indi-cate availabi¬lity at MGC and indralin both direct and indirect "bystander effect” of DNA-protective properties, as well as severe anxiolytic activity. Thus for indralin protection factor was 0.33 when in MGC it was 2.3 times higher (0.75.

  7. Estimation of neonatal outcome artery pH value according to CTG interpretation of the last 60 min before delivery: a retrospective study. Can the outcome pH value be predicted?

    Science.gov (United States)

    Kundu, S; Kuehnle, E; Schippert, C; von Ehr, J; Hillemanns, P; Staboulidou, Ismini

    2017-11-01

    The aim of this study was to analyze whether the umbilical artery pH value can be estimated throughout CTG assessment 60 min prior to delivery and if the estimated umbilical artery pH value correlates with the actual one. This includes analysis of correlation between CTG trace classification and actual umbilical artery pH value. Intra-and interobserver agreement and the impact of professional experience on visual analysis of fetal heart rate tracing were evaluated. This was a retrospective study. 300 CTG records of the last 60 min before delivery were picked randomly from the computer database with the following inclusion criteria; singleton pregnancy >37 weeks, no fetal anomalies, vaginal delivery either spontaneous or instrumental-assisted. Five obstetricians and two midwives of different professional experience classified 300 CTG traces according to the FIGO criteria and estimated the postnatal umbilical artery pH. The results showed a significant difference (p pH value, independent of professional experience. Analysis and correlation of CTG assessment and actual umbilical artery pH value showed significantly (p pH value and consequently of neonatal outcome on the basis of a present CTG seems to be difficult. Therefore, not only CTG training but also clinical experience and the collaboration and consultation within the whole team is important.

  8. A vida cotidiana na Educação Infantil: da ação reflexiva às minúcias da prática educativa

    Directory of Open Access Journals (Sweden)

    Altino José Martins Filho

    2015-08-01

    Full Text Available O artigo apresenta resultados de pesquisa realizada numa instituição de educação infantil na região da Grande Florianópolis/SC. O estudo descreve e analisa as diferentes minúcias da vida cotidiana no exercício da docência. Na pesquisa estreitou-se elos entre a Pedagogia da Infância e a Sociologia do Cotidiano, buscando interfaces interdisciplinares de modo compreender a docência como atividade reflexiva. A metodologia utilizada foi o estudo de caso, com registros escritos e fotográficos. A principal contribuição situa-se na compreensão que a ação reflexiva em torno das diferentes minúcias da vida cotidiana, possibilita entender a complexidade da própria vida vivida no coletivo da instituição educativa. Palavras-chave: Educação infantil; docência; professora de educação infantil; vida cotidiana.

  9. Effet de la nutrition minérale azotée sur le gain en biomasse de l'if du canada et sur le contenu en taxanes

    OpenAIRE

    Jollez, Pierre-Antoine

    2008-01-01

    Dans le cadre d'un vaste programme de domestication de l'if du Canada (Taxus canadensis Marsh.) à des fins de production de taxanes, de jeunes plants en première, deuxième ou troisième années de culture en contenants ont été soumis à différentes sources d'azote (nitrate d'ammonium, nitrate de calcium, nitrate de sodium, sulfate d'ammonium et urée), appliquées à différentes doses, et à divers pH du substrat pour étudier leur influence sur la croissance des plants, sur la teneur en éléments min...

  10. On Algorithms for Nonlinear Minimax and Min-Max-Min Problems and Their Efficiency

    Science.gov (United States)

    2011-03-01

    dissertation is complete, I can finally stay home after dinner to play Wii with you. LET’S GO Mario and Yellow Mushroom... xv THIS PAGE INTENTIONALLY... balance the accuracy of the approximation with problem ill-conditioning. The sim- plest smoothing algorithm creates an accurate smooth approximating...sizing in electronic circuit boards (Chen & Fan, 1998), obstacle avoidance for robots (Kirjner- Neto & Polak, 1998), optimal design centering

  11. The optimal protocol to reduce blood loss and blood transfusion after unilateral total knee replacement: Low-dose IA-TXA plus 30-min drain clamping versus drainage clamping for the first 3 h without IA-TXA.

    Science.gov (United States)

    Park, Joo Hyun; Choi, Sung Wook; Shin, Eun Ho; Park, Myung Hoon; Kim, Myung Ku

    2017-01-01

    Although intraarticular tranexamic acid (IA-TXA) administration or drainage clamping are popular methods used to reduce blood loss after total knee replacement (TKR), the protocol remains controversial. We aimed (1) to establish new protocols through investigating whether two methods, that is, low-dose (500 mg) IA-TXA plus 30-min drain clamping and drainage clamping for the first 3 h without IA-TXA, can reduce blood loss and blood transfusion after unilateral TKR and (2) to make recommendations related to clinical application. This study, conducted from September 2014 to June 2016 related to enrolled 95 patients with primary osteoarthritis who were to have a unilateral cemented TKR, was nonrandomized and retrospective. In group A, the drain was released following tourniquet deflation. In group B, 500-mg TXA was injected into the knee joint via a drain tube after fascia closure and the drain was clamped for the first 30 min to prevent leakage. In group C, the drain was clamped for the first 3-h postoperation. Demographic characteristics and clinical data were collected, including the levels of hematocrit (Hct), the total blood loss (TBL), drained blood volume (BV), the amount of blood transfused, and any complications that developed. We found a significantly lower postoperative TBL, drained BV, decreasing Hct level, and less transfused BV in the IA-TXA injection group (group B) and the 3-h drainage clamping group (group C) compared to the conventional negative drainage group (group A; p optimal than drainage clamping in patients with high bleeding tendency or lateral retinacular release during TKR, who would be concerned about postoperative wound complication.

  12. How much DNA is lost? Measuring DNA loss of short-tandem-repeat length fragments targeted by the PowerPlex 16® system using the Qiagen MinElute Purification Kit.

    Science.gov (United States)

    Kemp, Brian M; Winters, Misa; Monroe, Cara; Barta, Jodi Lynn

    2014-01-01

    The success in recovering genetic profiles from aged and degraded biological samples is diminished by fundamental aspects of DNA extraction, as well as its long-term preservation, that are not well understood. While numerous studies have been conducted to determine whether one extraction method was superior to others, nearly all of them were initiated with no knowledge of the actual starting DNA quantity in the samples prior to extraction, so they ultimately compared the outcome of all methods relative to the best. Using quantitative PCR to estimate the copy count of synthetic standards before (i.e., "copies in") and after (i.e., "copies out") purification by the Qiagen MinElute PCR Purification Kit, we documented DNA loss within a pool of 16 different-sized fragments ranging from 106 to 409 bp in length, corresponding to those targeted by the PowerPlex 16 System (Promega, Madison, WI). Across all standards from 10(4) to 10(7) copies/μL, loss averaged between 21.75% and 60.56% (mean, 39.03%), which is not congruent with Qiagen's claim that 80% of 70 bp to 4 kb fragments are retained using this product (i.e., 20% loss). Our study also found no clear relationship either between DNA strand length and retention or between starting copy number and retention. This suggests that there is no molecule bias across the MinElute column membrane and highlights the need for manufacturers to clearly and accurately describe on what their claims are based, and should also encourage researchers to document DNA retention efficiencies of their own methods and protocols. Understanding how and where to reduce loss of molecules during extraction and purification will serve to generate clearer and more accurate data, which will enhance the utility of ancient and low-copy-number DNA as a tool for closing forensic cases or in reconstructing the evolutionary history of humans and other organisms.

  13. Ultra-large scale synthesis of high electrochemical performance SnO{sub 2} quantum dots within 5 min at room temperature following a growth self-termination mechanism

    Energy Technology Data Exchange (ETDEWEB)

    Cui, Hongtao, E-mail: htcui@ytu.edu.cn; Xue, Junying; Ren, Wanzhong; Wang, Minmin

    2015-10-05

    Highlights: • SnO{sub 2} quantum dots were prepared at an ultra-large scale at room temperature within 5 min. • The grinding of SnCl{sub 2}⋅2H{sub 2}O and ammonium persulphate with morpholine produces quantum dots. • The reactions were self-terminated through the rapid consumption of water. • The obtained SnO{sub 2} quantum dots own high electrochemical performance. - Abstract: SnO{sub 2} quantum dots are prepared at an ultra-large scale by a productive synthetic procedure without using any organic ligand. The grinding of solid mixture of SnCl{sub 2}⋅2H{sub 2}O and ammonium persulphate with morpholine in a mortar at room temperature produces 1.2 nm SnO{sub 2} quantum dots within 5 min. The formation of SnO{sub 2} is initiated by the reaction between tin ions and hydroxyl groups generated from hydrolysis of morpholine in the released hydrate water from SnCl{sub 2}⋅2H{sub 2}O. It is considered that as water is rapidly consumed by the hydrolysis reaction of morpholine, the growth process of particles is self-terminated immediately after their transitory period of nucleation and growth. As a result of simple procedure and high toleration to scaling up of preparation, at least 50 g of SnO{sub 2} quantum dots can be produced in one batch in our laboratory. The as prepared quantum dots present high electrochemical performance due to the effective faradaic reaction and the alternative trapping of electrons and holes.

  14. Independent from muscle power and balance performance, a creatinine clearance below 65 ml/min is a significant and independent risk factor for falls and fall-related fractures in elderly men and women diagnosed with osteoporosis.

    Science.gov (United States)

    Dukas, L; Schacht, E; Runge, M

    2010-07-01

    We assessed in a cross-sectional study in elderly men and women with osteoporosis, the association between the creatinine clearance (CrCl) and the performance in different balance and muscle power and function tests and found that a decreasing creatinine clearance was significantly associated with lower balance and muscle power. To determine if a creatinine clearance of balance and an increased risk for falls and fractures. We assessed in a cross-sectional-study in 1781 German osteoporotic patients, the association between the CrCl, the physical performance, and the number of falls and fractures. Controlling for age, gender, BMI, and osteoporosis treatment (fracture analysis only), a decreasing CrCl was associated with lower physical performance in the timed-up-and-go test (corr -0.2337, P risk for falls (47.7% vs. 36.2%, P = 0.0008) and fall-related fractures (33.1% vs. 22.9%, P = 0.0003) compared with a CrCl of >or=65 ml/min. In this study, we found a significant gender-independent correlation between decreasing CrCl and lower performance in balance and muscle power tests. Reduced muscle power and balance may therefore be involved in the low creatinine clearance associated increased risk for falls and fall-related fractures. Furthermore, we found that a CrCl balance tests, is a significant risk factor for falls and fractures.

  15. Etätyökäytäntöjen kehittäminen

    OpenAIRE

    Haverinen, Liisa

    2017-01-01

    Opinnäytetyön tavoitteena oli luoda selvitys kohdeyritykselle siihen, kannattaako yrityksessä tehdä etätöitä laajemmin. Lähtötilanne oli, että etätöitä tehdään yrityksessä osittain. Etätöitä tekeviä työntekijöitä on kuitenkin vähän, ja etätöitä tehdään myös määrällisesti vähän. Työn alussa kerrotaan etätyöstä ilmiönä ja käsitteenä. Teoriaosuudessa selvitetään vastuita, hyötyjä ja haasteita liittyen etätöihin. Selvitetään myös etäjohtamisen ominaispiirteitä. Teoriaosuudessa käydään läpi e...

  16. 3D-virtuaaliympäristöjen toteuttaminen internetissä

    OpenAIRE

    Imberg, Sanna

    2008-01-01

    Tämä opinnäytetyö käsittelee internetissä toimivia virtuaalitodellisuuspalveluja sekä niihin luotavien 3D-mallien tekemiseen liittyviä prosesseja ja esitystekniikoita. Virtuaalitodellisuus käsitteenä luo ihmisille erilaisia mielikuvia. Yleisesti virtuaalitodellisuus käsitetään ensisijaisesti todellisuuden mallinnukseksi ja simuloinniksi tietokoneella. Tämän opinnäytetyön näkökulmasta virtuaalitodellisuuspalvelulla tarkoitetaan todellisten tai kuviteltujen paikkojen perusteella 3D-grafiikalla ...

  17. DR. ƒ. H. KROEZE, De TVancf op Jen Afoncf. Verklaring van het ...

    African Journals Online (AJOL)

    Test

    wel moeilikste van die Outestamentiese geskrifte. Hy ontleen die titel van sy studie aan 'n uitdrukking wat driemaal in die boek voorkom. (21:5, 29:9 en 39:37, Hebr. 40:5) en veral aan die laasgenoemde plek, waar dit die uiteindelike ootmoedige houding weergee waartoe die redes van die Here die Iyer gebring het: „Dit is ...

  18. NordStream : "Toru tuleb niikuinii" / Jens Müller ; interv. Külli-Riin Tigasson

    Index Scriptorium Estoniae

    Müller, Jens

    2007-01-01

    Nord Streami pressiesindaja hinnangul on Eesti majandusvööndis gaasijuhtme keskkonnauuringute mittelubamine keskkonna seisukohalt kahjulik, nüüd ei saa võrrelda, kas keskkonnasõbralikum oleks ehitada gaasitoru läbi Soome või läbi Eesti majandusvööndi

  19. Donkey in Disguise: Jack Jennings and the Center on Education Policy

    Science.gov (United States)

    Forster, Greg

    2006-01-01

    With the passage of the No Child Left Behind Act (NCLB), the proliferation of high school exit exams, the success of school choice initiatives, and a dozen other smaller if more bitter battles, education has become one of the hottest policy topics in Washington. That means there is a booming market for education experts, especially those who claim…

  20. Jens Kraft og "De vilde Folk" (1760) - manden, forfatterskbet, værket

    DEFF Research Database (Denmark)

    Langkjær, Michael Alexander

    2000-01-01

    had "set cultural development in motion." 7. Brief Account of the Savage Peoples from 1760, together with an address to the Academy of Young Noblemen at Sorø and Critical Letters for the Betterment of Taste, both from 1761, might be viewed as an interrelated group of sources bearing on one particular...... as religious concerns. 9. Kraft's reactions, as revealed by the contradictory tendencies in Brief Account of the Savage Peoples, testify to his unease with the paradoxes of modernity and its concomitant sense of value-loss. The dissertation is divided into three volumes.The first volume introduces the subject...

  1. Dialogi auttavissa verkkopalveluissa : Sosiaali- ja terveysjärjestöjen ammattilaisten kertomuksia kommunikaatiosta

    OpenAIRE

    Rahikka, Anne

    2013-01-01

    The development of information and communication technology has spread to social and health care organisations, which now offer interactive online services. The subject of this study is the work of social and health care professionals who offer their services online. In this study these online services are given the term online support services, which constitute a systematic method to help citizens cope in their everyday life. The point of view in this study comes from the narratives of the p...

  2. Indigenous Communities and Cross­Strait Rapprochement: A Case Study of Chun­-ri and Shih-­wen

    Directory of Open Access Journals (Sweden)

    Andi Kao

    2015-08-01

    Full Text Available Absent from most public debates on Taiwan’s embrace of neoliberal capitalism are the potential consequences of economic liberalization for Taiwan’s indigenous peoples. Deregulating markets and unfettering capital and resources are tied inextricably with cross-Strait politics. With a deep-seated apprehension of China still felt in many corners of the Taiwanese society, these issues are often framed with particular emphasis on the “China Factor”, overshadowing other relevant economic and societal considerations and thereby narrowing the scope of debate over government policies. Nevertheless, the potential influx of foreign capital investment, long- and short-term migrant labor and international visitors may have profound effects on Taiwan’s most vulnerable citizens, including the indigenous peoples. This paper will report the results of field research conducted among the Paiwan ethnic group, assessing actual and potential future changes affecting their individual families and communities. Preliminary assessment indicates that official policies liberalizing visitation and trade between China and Taiwan have already affected the Paiwan communities. Whether these changes become handicaps or opportunities depends on realistic evaluation, strategic planning, education, implementation, and periodic re-evaluation. This paper will contribute to the larger discussion of possible responses to the effects of inter-regional migration and transformations on minority societies by providing an assessment of current and potential conditions among the Paiwan of Taiwan.

  3. Development of {sup 115}Cd/{sup 115m}ln generator for industrial and environmental applications; Desenvolvimento de um gerador de {sup 115}Cd/{sup 115m}In para aplicacoes industriais e ambientais

    Energy Technology Data Exchange (ETDEWEB)

    Camargo, Fernanda Cristina Fonseca

    2012-07-01

    Indium isotopes, {sup 111}In, '1{sup 13}ln and {sup 115}In are widely used as radiotracers in industrial and environmental applications. {sup 113m}ln generators can be found in the international market. However they are manufactured by only a few companies worldwide, are rated at rather high prices and not always are available for sale (they are frequently manufactured only upon request). Hence it is of interest to produce the equipment in the country in which it will be used, especially if the parent nuclide can be also produced there. In Brazil, the ideal situation would be to produce a {sup 115}Cd/{sup 115m}In generator, whose target precursor is the '1{sup 14}Cd. Preliminary tests using non-enriched and inactive CdO were developed. The parent and daughter nuclides were separated flowing the eluate containing the chemical species Cd (II) and In (III) through ion exchange resins, Ag11A8, Chelex100 and Oowex 1 x8. 0.1 M, 1 M and 2M HCI and 2M HCI + 0.1 M NH{sub 4}CI solutions were tested as the eluant. The amount of Cd (l I) and In (III) eluted were determined by ICP-AES. The irradiation conditions of the target {sup 114}CdO were defined according to the neutron flux provided TRIGA MARK-I-R IPR reactor and the nuclear properties the of target. After to preliminary tests with the {sup 115}Cd/{sup 115m}In pair, column experiments were developed. Analyses were accomplished by gamma spectrometry to determine the presence of the {sup 115}Cd and {sup 115m}ln nuclides in the fractions eluted. Tests using the resin AG IIA8 and HCI I M eluent solution resulted in 100% adsorption of the Cd (11) and nearly 50% elution of In (III), corresponding to the best conditions for elution. Exposure to radiation can damage the resins, as the decrease in ion exchange capacity and change in volume of the polymer grains. Thus, columns packed with the chosen resin were exposed to radiation doses from 15 to 200 Gy, and eluted with the most effective eluent. The results showed that

  4. Rates and fluxes of centennial-scale carbon storage in the fine-grained sediments from the central South Yellow Sea and Min-Zhe belt, East China Sea

    Science.gov (United States)

    Wang, Jianghai; Xiao, Xi; Zhou, Qianzhi; Xu, Xiaoming; Zhang, Chenxi; Liu, Jinzhong; Yuan, Dongliang

    2018-01-01

    The global carbon cycle has played a key role in mitigating global warming and climate change. Long-term natural and anthropogenic processes influence the composition, sources, burial rates, and fluxes of carbon in sediments on the continental shelf of China. In this study, the rates, fluxes, and amounts of carbon storage at the centennial scale were estimated and demonstrated using the case study of three fine-grained sediment cores from the central South Yellow Sea area (SYSA) and Min-Zhe belt (MZB), East China Sea. Based on the high-resolution temporal sequences of total carbon (TC) and total organic carbon (TOC) contents, we reconstructed the annual variations of historical marine carbon storage, and explored the influence of terrestrial and marine sources on carbon burial at the centennial scale. The estimated TC storage over 100 years was 1.18×108 t in the SYSA and 1.45×109 t in the MZB. The corrected TOC storage fluxes at the centennial scale ranged from 17 to 28 t/(km2·a)in the SYSA and from 56 to 148 t/(km2·a) in the MZB. The decrease of terrestrial materials and the increase of marine primary production suggest that the TOC buried in the sediments in the SYSA and MZB was mainly derived from the marine autogenetic source. In the MZB, two depletion events occurred in TC and TOC storage from 1985 to 1987 and 2003 to 2006, which were coeval with the water impoundment in the Gezhouba and Three Gorges dams, respectively. The high-resolution records of the carbon storage rates and fluxes in the SYSA and MZB reflect the synchronous responses to human activities and provide an important reference for assessing the carbon sequestration capacity of the marginal seas of China.

  5. Individualizing pharmacotherapy in patients with renal impairment: the validity of the Modification of Diet in Renal Disease formula in specific patient populations with a glomerular filtration rate below 60 ml/min. A systematic review.

    Directory of Open Access Journals (Sweden)

    Willemijn L Eppenga

    Full Text Available The Modification of Diet in Renal Disease (MDRD formula is widely used in clinical practice to assess the correct drug dose. This formula is based on serum creatinine levels which might be influenced by chronic diseases itself or the effects of the chronic diseases. We conducted a systematic review to determine the validity of the MDRD formula in specific patient populations with renal impairment: elderly, hospitalized and obese patients, patients with cardiovascular disease, cancer, chronic respiratory diseases, diabetes mellitus, liver cirrhosis and human immunodeficiency virus.We searched for articles in Pubmed published from January 1999 through January 2014. Selection criteria were (1 patients with a glomerular filtration rate (GFR < 60 ml/min (/1.73 m2, (2 MDRD formula compared with a gold standard and (3 statistical analysis focused on bias, precision and/or accuracy. Data extraction was done by the first author and checked by a second author. A bias of 20% or less, a precision of 30% or less and an accuracy expressed as P30% of 80% or higher were indicators of the validity of the MDRD formula. In total we included 27 studies. The number of patients included ranged from 8 to 1831. The gold standard and measurement method used varied across the studies. For none of the specific patient populations the studies provided sufficient evidence of validity of the MDRD formula regarding the three parameters. For patients with diabetes mellitus and liver cirrhosis, hospitalized patients and elderly with moderate to severe renal impairment we concluded that the MDRD formula is not valid. Limitations of the review are the lack of considering the method of measuring serum creatinine levels and the type of gold standard used.In several specific patient populations with renal impairment the use of the MDRD formula is not valid or has uncertain validity.

  6. Une masculinité en crise à la fin du XVIIe siècle ? La critique de l'efféminé chez La Bruyère

    Directory of Open Access Journals (Sweden)

    Cédric Corgnet

    2008-07-01

    Full Text Available L’efféminé est toujours un cas sexuel limite : homme aux airs féminins, il interroge l’innée de la nature sexuelle, critique les genres et leur définition explicitement physique. La fin du XVIIe siècle illustre cette tension chez les moralistes français et surtout chez La Bruyère dans ses Caractères où celui-ci interroge cette monstruosité générique à travers une analyse sémiologique. Mais cette tératologie n’est pas avant tout clinique mais sociale et morale : il nous avertit, par cet écart de genre, d’une corruption morale du monde tant par une sémiologie clinique que mythologique ovidienne ne cherchant pas le réalisme pathologique mais la filiation antique qui ante son ouvrage sur les Caractères Théophrastiens : philosophe plus que naturaliste.The effeminate is always a sexual limit case: man in the feminine sights, he questions the innate of the sexual nature, criticizes genders and their explicitly physical definition. The end of the XVIIth century illustrates this tension at the French moralists and especially in La Bruyère’s Characters where this one questions this generic monstrousness through a semiological analysis. But this teratology is not above all clinical but social and moral: he warns us, by this distance from gender, from a moral corruption of the world both by a clinical semiology and ovidian mythology not looking for the pathological realism but the antic filiation with Theophrast’s Characters : philosopher more than naturalist.

  7. MinXSS-1 CubeSat On-Orbit Pointing and Power Performance: The First Flight of the Blue Canyon Technologies XACT 3-axis Attitude Determination and Control System

    Science.gov (United States)

    Mason, James Paul; Baumgart, Matt; Rogler, Bryan; Downs, Chloe; Williams, Margaret; Woods, Thomas N.; Palo, Scott; Chamberlin, Phillip C.; Solomon, Stanley; Jones, Andrew; Li, Xinlin; Kohnert, Rick; Caspi, Amir

    2017-12-01

    The Miniature X-ray Solar Spectrometer (MinXSS) is a three-unit (3U) CubeSat designed for a three-month mission to study solar soft X-ray spectral irradiance. The first of the two flight models was deployed from the International Space Station in May 2016, and operated for one year before its natural deorbiting. This was the first flight of the Blue Canyon Technologies XACT 3-axis attitude determination and control system - a commercially available, high-precision pointing system. The performance of the pointing system on orbit was characterized, including performance at low altitudes where drag torque builds up. It was found that the pointing accuracy was 0.0042° - 0.0117° (15" - 42", 3σ, axis dependent) consistently from 190 km - 410 km, slightly better than the specification sheet states. Peak-to-peak jitter was estimated to be 0.0073° (10 s^-1) - 0.0183° (10 s^-1) (26" (10 s^-1) - 66" (10 s^-1), 3σ). The system was capable of dumping mome ntum until an altitude of 185 km. Small amounts of sensor degradation were found in the star tracker and coarse sun sensor. The mission profile did not require high-agility maneuvers, so it was not possible to characterize this metric. Without a GPS receiver, it was necessary to periodically upload ephemeris information to update the orbit propagation model and maintain pointing. At 400 km, these uploads were required once every other week; at ˜270 km, they were required every day. The power performance of the electric power system was also characterized, including use of a novel pseudo-peak power tracker - a resistor that limited the current draw from the battery on the solar panels. With 19 30% efficient solar cells and an 8 W system load, the power balance had 65% of margin on orbit. The current paper presents several recommendations to other CubeSat programs throughout.

  8. Relationship between resistant hypertension and arterial stiffness assessed by brachial-ankle pulse wave velocity in the older patient

    Directory of Open Access Journals (Sweden)

    Chung CM

    2014-09-01

    Full Text Available Chang-Min Chung,1,2 Hui-Wen Cheng,2 Jung-Jung Chang,2 Yu-Sheng Lin,2 Ju-Feng Hsiao,2 Shih-Tai Chang,1 Jen-Te Hsu2,31School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, 2Division of Cardiology, Chang Gung Memorial Hospital, Chiayi, 3Department of Medicine, College of Medicine, Chang Gung University, Taoyuan County, TaiwanBackground: Resistant hypertension (RH is a common clinical condition associated with increased cardiovascular mortality and morbidity in older patients. Several factors and conditions interfering with blood pressure (BP control, such as excess sodium intake, obesity, diabetes, older age, kidney disease, and certain identifiable causes of hypertension are common in patients resistant to antihypertensive treatment. Arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV, is increasingly recognized as an important prognostic index and potential therapeutic target in hypertensive patients. The aim of this study was to determine whether there is an association between RH and arterial stiffness. Methods: This study included 1,620 patients aged ≥65 years who were referred or self-referred to the outpatient hypertension unit located at a single cardiovascular center. They were separated into normotensive, controlled BP, and resistant hypertension groups. Home BP, blood laboratory parameters, echocardiographic studies and baPWV all were measured. Results: The likelihood of diabetes mellitus was significantly greater in the RH group than in the group with controlled BP (odds ratio 2.114, 95% confidence interval [CI] 1.194–3.744, P=0.010. Systolic BP was correlated in the RH group significantly more than in the group with controlled BP (odds ratio 1.032, 95% CI 1.012–1.053, P=0.001. baPWV (odds ratio 1.084, 95% CI 1.016–1.156, P=0.015 was significantly correlated with the presence of RH. The other factors were negatively correlated with the existence of RH.Conclusion: In

  9. Approche au diagnostic de la maladie cœliaque chez les patients ayant une faible densité minérale osseuse ou des fractures de fragilité

    Science.gov (United States)

    Rios, Lorena P.; Khan, Aliya; Sultan, Muhammad; McAssey, Karen; Fouda, Mona A.; Armstrong, David

    2013-01-01

    Résumé Objectif Présenter aux cliniciens une mise à jour sur le diagnostic de la maladie cœliaque (MC), ainsi que des recommandations sur les indications de procéder au dépistage de la MC chez les patients présentant une faible densité minérale osseuse (DMO) ou des fractures de fragilité. Qualité des données Un groupe de travail multidisciplinaire a élaboré des questions cliniquement pertinentes relativement au diagnostic de la MC servant de fondement à une recherche documentaire dans les bases de données MEDLINE, EMBASE et CENTRAL (de janvier 2000 à janvier 2009) à l’aide des mots clés en anglais celiac disease, osteoporosis, osteopenia, low bone mass et fracture. Les ouvrages scientifiques existants comportent des études de niveaux I et II. Message principal La prévalence estimée de la MC asymptomatique est de 2 % à 3 % chez les personnes qui ont une faible DMO. Par ailleurs, un dépistage ciblé est recommandé pour les patients qui ont des T-scores de −1,0 ou moins à la colonne vertébrale ou aux hanches ou des antécédents de fractures de fragilité associées à des symptômes ou à des problèmes reliés à la MC, des antécédents familiaux de MC ou de bas niveaux de calcium urinaire, une insuffisance en vitamine D et des niveaux à la hausse d’hormones parathyroïdiennes en dépit d’un apport suffisant en calcium et en vitamine D. Le dépistage de la MC devrait se faire pendant que le sujet consomme un régime alimentaire contenant du gluten. On procède au dépistage initial par le dosage d’immunoglobuline (Ig) A antitransglutaminase en utilisant la transglutaminase tissulaire humaine recombinante ou une autre transglutaminase tissulaire, en association avec l’immunofluorescence des IgA anti-endomysium. Une biopsie du duodénum est nécessaire pour confirmer le diagnostic de la MC. Le typage des antigènes des leucocytes humains peut aider à confirmer ou à exclure le diagnostic de la MC dans les cas où la s

  10. Synthesis of coloured ceramic pigments by using chromite and manganese ores mixtures Síntese de pigmentos cerâmicos coloridos usando misturas de cromita e de minérios de manganês

    Directory of Open Access Journals (Sweden)

    M. H Aly

    2010-06-01

    Full Text Available The aim of this work is not only the synthesis of black ceramic pigment with spinel structure using local and inexpensive minerals (chromite and manganese ores but also throw some light on the relations between the structure and the colour of obtained pigment. Ultimate utilization spinel solid solution in ceramic materials is mostly due to their structure characteristics, their thermal and chemical stability. In this study colour pigments were ned by calcinations at 1250 ºC starting from a mixture of chromite and manganese oxide. Different compositions were tested containing 30, 40 and 50 wt.% of manganese oxide (low and high content respectively. The phase composition and microstructure characterization of both raw material and obtained pigments were evaluated by X-ray diffraction, X-ray fluorescence, polarizing microscope and scanning electron microscope. Furthermore, the colour measurements of the obtained pigments and tiles were evaluated. Composition of all pigments reveal the spinel structure with Cr2FeO4; hematite was also recorded in the mixture of low manganese. The degree of lightness is relatively same in the pigments mixtures of both manganese types. However, tiles could be considered lightness compared with its pigments, especially of the high manganese type. The solid state calcinations reactions are indeed able to form intense brown pigments that can be used as a stain for industrial ceramic applications. The production of less expensive black ceramic pigments from low cost and less pure raw materials that can be utilized in Egypt to substitute for the imported pure oxides or salts is proved superior performance for producing painted pigments.O objetivo deste trabalho é não somente a síntese de pigmento cerâmico negro com estrutura espinélio usando minerais locais e de baixo custo (minérios de cromita e manganês mas também pesquisar as relações entre a estrutura e a cor dos pigmentos obtidos. O porquê da utiliza

  11. Protective Effect of 2-Dodecyl-6-Methoxycyclohexa-2, 5-Diene-1, 4-Dione, Isolated from Averrhoa Carambola L., Against Palmitic Acid-Induced Inflammation and Apoptosis in Min6 Cells by Inhibiting the TLR4-MyD88-NF-κB Signaling Pathway

    Directory of Open Access Journals (Sweden)

    Qiuqiao Xie

    2016-09-01

    Full Text Available Background/Aims: Studies have demonstrated that 2-dodecyl-6-methoxycyclohexa-2, 5-diene-1, 4-dione (DMDD, isolated from the roots of Averrhoa carambola L., has significant therapeutic potential for the treatment of diabetes. However, the protective effect of DMDD against pancreatic beta cell dysfunction has never been reported. We investigated whether DMDD protected against palmitic acid-induced dysfunction in pancreatic β-cell line Min6 cells by attenuating the inflammatory response and apoptosis and to shed light on its possible mechanism. Methods: Cell viability was assessed by CCK-8. Glucose-stimulated insulin secretion levels and inflammatory cytokines levels were examined by ELISA. Apoptosis was assessed by Annexin V-FITC/PI Flow cytometry assay, Hoechst 33342/PI double-staining assay, and Transmission electron microscopy assay. Relative quantitative real-time PCR and western blot were used to determine the expressions of genes and proteins. Results: Cell viability and glucose-stimulated insulin secretion levels were increased in DMDD-pretreated Min6 cells. DMDD inhibited inflammatory cytokines IL-6, TNF-α and MCP-1 generations in palmitic acid (PA-induced Min6 cells. Moreover, DMDD protected against PA-induced Min6 cells apoptosis and the expression of Cleaved-Caspase-3, -8 and -9 were down-regulated and the Bcl-2/Bax ratio was increased in DMDD-pretreated Min6 cells. In addition, the expression of TLR4, MyD88 and NF-κB were down-regulated in DMDD-pretreated Min6 cells and TAK-242-pretreated group cells. Conclusions: DMDD protected Min6 cells against PA-induced dysfunction by attenuating the inflammatory response and apoptosis, and its mechanism of this protection was associated with inhibiting the TLR4-MyD88-NF-κB signaling pathway.

  12. Protective Effect of 2-Dodecyl-6-Methoxycyclohexa-2, 5-Diene-1, 4-Dione, Isolated from Averrhoa Carambola L., Against Palmitic Acid-Induced Inflammation and Apoptosis in Min6 Cells by Inhibiting the TLR4-MyD88-NF-κB Signaling Pathway.

    Science.gov (United States)

    Xie, Qiuqiao; Zhang, Shijun; Chen, Chunxia; Li, Juman; Wei, Xiaojie; Xu, Xiaohui; Xuan, Feifei; Chen, Ning; Pham, Thithaihoa; Qin, Ni; He, Junhui; Ye, Fangxing; Huang, Wansu; Huang, Renbin; Wen, Qingwei

    2016-01-01

    Studies have demonstrated that 2-dodecyl-6-methoxycyclohexa-2, 5-diene-1, 4-dione (DMDD), isolated from the roots of Averrhoa carambola L., has significant therapeutic potential for the treatment of diabetes. However, the protective effect of DMDD against pancreatic beta cell dysfunction has never been reported. We investigated whether DMDD protected against palmitic acid-induced dysfunction in pancreatic β-cell line Min6 cells by attenuating the inflammatory response and apoptosis and to shed light on its possible mechanism. Cell viability was assessed by CCK-8. Glucose-stimulated insulin secretion levels and inflammatory cytokines levels were examined by ELISA. Apoptosis was assessed by Annexin V-FITC/PI Flow cytometry assay, Hoechst 33342/PI double-staining assay, and Transmission electron microscopy assay. Relative quantitative real-time PCR and western blot were used to determine the expressions of genes and proteins. Cell viability and glucose-stimulated insulin secretion levels were increased in DMDD-pretreated Min6 cells. DMDD inhibited inflammatory cytokines IL-6, TNF-α and MCP-1 generations in palmitic acid (PA)-induced Min6 cells. Moreover, DMDD protected against PA-induced Min6 cells apoptosis and the expression of Cleaved-Caspase-3, -8 and -9 were down-regulated and the Bcl-2/Bax ratio was increased in DMDD-pretreated Min6 cells. In addition, the expression of TLR4, MyD88 and NF-κB were down-regulated in DMDD-pretreated Min6 cells and TAK-242-pretreated group cells. DMDD protected Min6 cells against PA-induced dysfunction by attenuating the inflammatory response and apoptosis, and its mechanism of this protection was associated with inhibiting the TLR4-MyD88-NF-κB signaling pathway. © 2016 The Author(s) Published by S. Karger AG, Basel.

  13. A combination of high dose rate (10X FFF/2400 MU/min/10 MV X-rays) and total low dose (0.5 Gy) induces a higher rate of apoptosis in melanoma cells in vitro and superior preservation of normal melanocytes.

    Science.gov (United States)

    Sarojini, Sreeja; Pecora, Andrew; Milinovikj, Natasha; Barbiere, Joseph; Gupta, Saakshi; Hussain, Zeenathual M; Tuna, Mehmet; Jiang, Jennifer; Adrianzen, Laura; Jun, Jaewook; Catello, Laurice; Sanchez, Diana; Agarwal, Neha; Jeong, Stephanie; Jin, Youngjin; Remache, Yvonne; Goy, Andre; Ndlovu, Alois; Ingenito, Anthony; Suh, K Stephen

    2015-10-01

    The aim of this study was to determine the apoptotic effects, toxicity, and radiosensitization of total low dose irradiation delivered at a high dose rate in vitro to melanoma cells, normal human epidermal melanocytes (HEM), or normal human dermal fibroblasts (HDF) and to study the effect of mitochondrial inhibition in combination with radiation to enhance apoptosis in melanoma cells. Cells irradiated using 10X flattening filter-free (FFF) 10 MV X-rays at a dose rate of 400 or 2400 MU/min and a total dose of 0.25-8 Gy were analyzed by cell/colony counting, MitoTracker, MTT, and DNA-damage assays, as well as by quantitative real-time reverse transcriptase PCR in the presence or absence of mitochondrial respiration inhibitors. A dose rate of 2400 MU/min killed on average five-fold more melanoma cells than a dose rate 400 MU/min at a total dose of 0.5 Gy and preserved 80% survival of HEM and 90% survival of HDF. Increased apoptosis at the 2400 MU/min dose rate is mediated by greater DNA damage, reduced cell proliferation, upregulation of apoptotic genes, and downregulation of cell cycle genes. HEM and HDF were relatively unharmed at 2400 MU/min. Radiation induced upregulation of mitochondrial respiration in both normal and cancer cells, and blocking the respiration with inhibitors enhanced apoptosis only in melanoma cells. A high dose rate with a low total dose (2400 MU/min, 0.5 Gy/10X FFF 10 MV X-rays) enhances radiosensitivity of melanoma cells while reducing radiotoxicity toward HEM and HDF. Selective cytotoxicity of melanoma cells is increased by blocking mitochondrial respiration.

  14. Evaluation excitation functions for "2"8Si(n,p)"2"8Al, "3"1P(n,p)"3"1Si, and "1"1"3In(n,γ)"1"1"4"mIn reactions

    International Nuclear Information System (INIS)

    Zolotarev, K.I.

    2014-10-01

    Cross section data for "2"8Si(n,p)"2"8Al, "3"1P(n,p)"3"1Si and "1"1"3In(n,γ)"1"1"4"mIn reactions are needed for solving a wide spectrum of scientific and technical tasks. The excitation function of "2"8Si(n,p)"2"8Al reaction refers to the nuclear data involved in fusion reactor design calculations. The "2"8Si(n,p)"2"8Al reaction is interesting also as the monitor reaction for measurements at fusion facilities. Activation detectors on the basis of the 31P(n,p)31Si reaction are commonly used in the reactor dosimetry. The "1"1"3In(n,γ)"1"1"4"mIn reaction is promising regarding reactor dosimetry application for two reasons. First, due to the "1"1"4"mIn decay parameters which are rather suitable for activation measurements. Half-life of "1"1"4"mIn is equal to T_1/_2 = (49.51 ± 0.01) days and gamma spectrum accompanying decay has only one line with energy 190.27 keV and intensity (15.56 ± 0.15)%. Second, the "1"1"3In(n,γ)"1"1"4"mIn reaction rate may be measured by using one activation detector simultaneously with the "1"1"5In(n,γ)"1"1"6"mIn reaction. Preliminary analysis of existing evaluated excitation functions for "2"8Si(n,p)"2"8Al, "3"1P(n,p)"3"1Si and "1"1"3In(n,γ)"1"1"4"mIn reactions show that new evaluations are needed for all above mentioned reactions. This report is devoted to the preparation of the new evaluations of cross sections data and related covariance matrixes of uncertainties for the "2"8Si(n,p)"2"8Al, "3"1P(n,p)"3"1Si and "1"1"3In(n,γ)"1"1"4"mIn reactions.

  15. Deeply inelastic scattering at small x in 20 min

    International Nuclear Information System (INIS)

    Levin, E.M.

    1992-01-01

    A status report is presented on new phenomena that are anticipated in deeply inelastic scattering in the low x→0 region. A summary of the theoretical situation in the region of small x is given, including the importance for the understanding of high energy interaction in QCD, and the low x behaviour of deep inelastic structure function. This new area of physics will be studied experimentally at HERA. (R.P.) 16 refs.; 6 figs

  16. Tanssijan roolityö : Minä toisena

    OpenAIRE

    Penttilä, Elena

    2012-01-01

    Tanssi ja teatteri, sekä näyttämöllisyyden mahdollisuudet ja haasteet, kiehtovat minua. Taiteellisen opinnäytetyöni innoittajana on toiminut tahtoni löytää työskentelymuoto, jossa tanssija kykenisi hyödyntämään näyttelijäntyön perusteita tuodakseen keholliseen ilmaisuunsa moniulotteisuutta ja syvyyttä. Opinnäytetyöni produktiotyöskentelyssä roolityön lähtökohtana toimivat eri aistikanavia pitkin tarjotut impulssit, näyttämötilan käsittäminen paikkana sekä teokselle luotu tarinamuotoinen t...

  17. Variable operator technique and the min-max theorem

    Indian Academy of Sciences (India)

    We investigate a variation method where the trial function is generated from the application of a variable operator on a reference function. Two conditions are identified, one for obtaining a maximum and another for a minimum. Although the conditions are easy to understand, the overall formulation is somewhat unusual as ...

  18. 2.5-min gravity grid of N. America

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The dgrav gridded data set was produced by NGDC by regridding the Decade of North American (DNAG) 6-km gravity grid of N. America. A grid cell dimension of 2.5...

  19. Alaska Gravity Data per 2 x 4 min Cell (96)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' x 4' gravity density grid for Alaska displays the distribution of about 1.1 million terrestrial and marine gravity data held in the National Geodetic Survey...

  20. PR/VI Gravity Data per 2 min Cell (96)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' gravity density grid for Puerto Rico and the Virgin Islands displays the distribution of about 26,000 terrestrial and marine gravity data held in the...