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Sample records for shift perturbation analysis

  1. Perturbation method utilization in the analysis of the Convertible Spectral Shift Reactor (RCVS)

    Bruna, G.B; Legendre, J.F.; Porta, J.; Doriath, J.Y.

    1988-01-01

    In the framework of the preliminary faisability studies on a new core concept, techniques derived from perturbation theory show-up very useful in the calculation and physical analysis of project parameters. We show, in the present work, some applications of these methods to the RCVS (Reacteur Convertible a Variation de Spectre - Convertible Spectral Shift Reactor) Concept studies. Actually, we present here the search of a few group project type energy structure and the splitting of reactivity effects into individual components [fr

  2. Perturbation of frame sequences in shift-invariant spaces

    Christensen, Ole; Kim, Hong Oh; Kim, Rae Young

    2005-01-01

    We prove a new perturbation criteria for frame sequences, which generalizes previous results and is easier to apply. In the special case of frames infinitely generated shift-invariant subspaces of L2(ℝd) the condition can be formulated in terms of the norm of a finite Gram matrix and a correspond...

  3. Using chemical shift perturbation to characterise ligand binding.

    Williamson, Mike P

    2013-08-01

    Chemical shift perturbation (CSP, chemical shift mapping or complexation-induced changes in chemical shift, CIS) follows changes in the chemical shifts of a protein when a ligand is added, and uses these to determine the location of the binding site, the affinity of the ligand, and/or possibly the structure of the complex. A key factor in determining the appearance of spectra during a titration is the exchange rate between free and bound, or more specifically the off-rate koff. When koff is greater than the chemical shift difference between free and bound, which typically equates to an affinity Kd weaker than about 3μM, then exchange is fast on the chemical shift timescale. Under these circumstances, the observed shift is the population-weighted average of free and bound, which allows Kd to be determined from measurement of peak positions, provided the measurements are made appropriately. (1)H shifts are influenced to a large extent by through-space interactions, whereas (13)Cα and (13)Cβ shifts are influenced more by through-bond effects. (15)N and (13)C' shifts are influenced both by through-bond and by through-space (hydrogen bonding) interactions. For determining the location of a bound ligand on the basis of shift change, the most appropriate method is therefore usually to measure (15)N HSQC spectra, calculate the geometrical distance moved by the peak, weighting (15)N shifts by a factor of about 0.14 compared to (1)H shifts, and select those residues for which the weighted shift change is larger than the standard deviation of the shift for all residues. Other methods are discussed, in particular the measurement of (13)CH3 signals. Slow to intermediate exchange rates lead to line broadening, and make Kd values very difficult to obtain. There is no good way to distinguish changes in chemical shift due to direct binding of the ligand from changes in chemical shift due to allosteric change. Ligand binding at multiple sites can often be characterised, by

  4. Perturbation analysis of octupoles in circular accelerators

    Moohyun Yoon

    1998-01-01

    The octupole effects in a circular accelerator are analyzed using a first-order canonical perturbation theory. It is shown that, to the first order, the nonlinear amplitude-dependent tune shifts due to an octupole are composed of two types: terms of second order and terms of fourth order in betatron-oscillation amplitudes. The fourth-order part of tune shifts is expressed in terms of distortion functions. Distortion functions are also expanded in harmonics to express the higher-order tune shifts in harmonically expanded form. Finally, the results are applied to an accelerator and compared with the results of numerical tracking of particles. Laskar's algorithm for numerical analysis of the fundamental frequency is used to determine tunes from the tracking data, in which the error becomes inversely proportional to the cube of the number of data points. (author)

  5. Shifted Independent Component Analysis

    Mørup, Morten; Madsen, Kristoffer Hougaard; Hansen, Lars Kai

    2007-01-01

    Delayed mixing is a problem of theoretical interest and practical importance, e.g., in speech processing, bio-medical signal analysis and financial data modelling. Most previous analyses have been based on models with integer shifts, i.e., shifts by a number of samples, and have often been carried...

  6. Perturbation analysis of linear control problems

    Petkov, Petko; Konstantinov, Mihail

    2017-01-01

    The paper presents a brief overview of the technique of splitting operators, proposed by the authors and intended for perturbation analysis of control problems involving unitary and orthogonal matrices. Combined with the technique of Lyapunov majorants and the implementation of the Banach and Schauder fixed point principles, it allows to obtain rigorous non-local perturbation bounds for a set of sensitivity analysis problems. Among them are the reduction of linear systems into orthogonal canonical forms, the feedback synthesis problem and pole assignment problem in particular, as well as other important problems in control theory and linear algebra. Key words: perturbation analysis, canonical forms, feedback synthesis

  7. Numerical Integration of a Class of Singularly Perturbed Delay Differential Equations with Small Shift

    Gemechis File

    2012-01-01

    Full Text Available We have presented a numerical integration method to solve a class of singularly perturbed delay differential equations with small shift. First, we have replaced the second-order singularly perturbed delay differential equation by an asymptotically equivalent first-order delay differential equation. Then, Simpson’s rule and linear interpolation are employed to get the three-term recurrence relation which is solved easily by discrete invariant imbedding algorithm. The method is demonstrated by implementing it on several linear and nonlinear model examples by taking various values for the delay parameter and the perturbation parameter .

  8. Nu shifts in betatron oscillations from uniform perturbations in the presence of non-linear magnetic guide fields

    Crebbin, K.C.

    1985-05-01

    Uniform magnetic field perturbations cause a closed orbit distortion in a circular accelerator. If the magnetic guide field is non-linear these perturbations can also cause a Nu shift in the betatron oscillations. Such a shift in radial Nu values has been observed in the Bevalac while studying the low energy resonant extraction system. In the Bevalac, the radial perturbation comes from the quadrants being magnetically about 0.8% longer than 90 0 . The normal effect of this type of perturbation is a radial closed orbit shift and orbit distortion. The Nu shift, associated with this type of perturbation in the presence of a non-linear guide field, is discussed in this paper. A method of handling the non-linear n values is discussed as well as the mechanism for the associated Nu shift. Computer calculations are compared to measurements. 2 refs., 4 figs

  9. Low energy pion-pion phase shifts from chiral perturbation theory

    Borges, J. Sa; Barbosa, J. Soares; Oguri, V.

    1997-01-01

    The low energy pion-pion S- and P- experimental phase-shifts are fitted with chiral perturbation theory (Ch PT) amplitude. The low energy pion-pion S- and P- experimental phase-shifts. The parameters l 1 and l 2 of the one loop corrected amplitude are fixed and the corresponding values of the scattering lengths are calculated. We propose that the present method is the best way to fix Ch P T parameters. The unitarization program of current algebra is also discussed. (author)

  10. Perturbation analysis of nonlinear matrix population models

    Hal Caswell

    2008-03-01

    Full Text Available Perturbation analysis examines the response of a model to changes in its parameters. It is commonly applied to population growth rates calculated from linear models, but there has been no general approach to the analysis of nonlinear models. Nonlinearities in demographic models may arise due to density-dependence, frequency-dependence (in 2-sex models, feedback through the environment or the economy, and recruitment subsidy due to immigration, or from the scaling inherent in calculations of proportional population structure. This paper uses matrix calculus to derive the sensitivity and elasticity of equilibria, cycles, ratios (e.g. dependency ratios, age averages and variances, temporal averages and variances, life expectancies, and population growth rates, for both age-classified and stage-classified models. Examples are presented, applying the results to both human and non-human populations.

  11. Perturbative analysis in higher-spin theories

    Didenko, V.E. [I.E. Tamm Department of Theoretical Physics, Lebedev Physical Institute,Leninsky prospect 53, 119991, Moscow (Russian Federation); Misuna, N.G. [Moscow Institute of Physics and Technology,Institutsky lane 9, 141700, Dolgoprudny, Moscow region (Russian Federation); Vasiliev, M.A. [I.E. Tamm Department of Theoretical Physics, Lebedev Physical Institute,Leninsky prospect 53, 119991, Moscow (Russian Federation)

    2016-07-28

    A new scheme of the perturbative analysis of the nonlinear HS equations is developed giving directly the final result for the successive application of the homotopy integrations which appear in the standard approach. It drastically simplifies the analysis and results from the application of the standard spectral sequence approach to the higher-spin covariant derivatives, allowing us in particular to reduce multiple homotopy integrals resulting from the successive application of the homotopy trick to a single integral. Efficiency of the proposed method is illustrated by various examples. In particular, it is shown how the Central on-shell theorem of the free theory immediately results from the nonlinear HS field equations with no intermediate computations.

  12. Perturbation analysis for patch occupancy dynamics

    Martin, Julien; Nichols, James D.; McIntyre, Carol L.; Ferraz, Goncalo; Hines, James E.

    2009-01-01

    Perturbation analysis is a powerful tool to study population and community dynamics. This article describes expressions for sensitivity metrics reflecting changes in equilibrium occupancy resulting from small changes in the vital rates of patch occupancy dynamics (i.e., probabilities of local patch colonization and extinction). We illustrate our approach with a case study of occupancy dynamics of Golden Eagle (Aquila chrysaetos) nesting territories. Examination of the hypothesis of system equilibrium suggests that the system satisfies equilibrium conditions. Estimates of vital rates obtained using patch occupancy models are used to estimate equilibrium patch occupancy of eagles. We then compute estimates of sensitivity metrics and discuss their implications for eagle population ecology and management. Finally, we discuss the intuition underlying our sensitivity metrics and then provide examples of ecological questions that can be addressed using perturbation analyses. For instance, the sensitivity metrics lead to predictions about the relative importance of local colonization and local extinction probabilities in influencing equilibrium occupancy for rare and common species.

  13. Application of depletion perturbation theory to fuel cycle burnup analysis

    White, J.R.

    1979-01-01

    Over the past several years static perturbation theory methods have been increasingly used for reactor analysis in lieu of more detailed and costly direct computations. Recently, perturbation methods incorporating time dependence have also received attention, and several authors have demonstrated their applicability to fuel burnup analysis. The objective of the work described here is to demonstrate that a time-dependent perturbation method can be easily and accurately applied to realistic depletion problems

  14. MCNP perturbation technique for criticality analysis

    McKinney, G.W.; Iverson, J.L.

    1995-01-01

    The differential operator perturbation technique has been incorporated into the Monte Carlo N-Particle transport code MCNP and will become a standard feature of future releases. This feature includes first and/or second order terms of the Taylor Series expansion for response perturbations related to cross-section data (i.e., density, composition, etc.). Criticality analyses can benefit from this technique in that predicted changes in the track-length tally estimator of K eff may be obtained for multiple perturbations in a single run. A key advantage of this method is that a precise estimate of a small change in response (i.e., < 1%) is easily obtained. This technique can also offer acceptable accuracy, to within a few percent, for up to 20-30% changes in a response

  15. Transport perturbation theory in nuclear reactor analysis

    Nishigori, Takeo; Takeda, Toshikazu; Selvi, S.

    1985-01-01

    Perturbation theory is formulated on the basis of transport theory to obtain a formula for the reactivity changes due to possible variations of cross sections. Useful applications to cell homogenization are presented for the whole core calculation in transport and in diffusion theories. (author)

  16. Perturbative analysis of non-Abelian Aharonov-Bohm scattering

    Bak, D.; Bergman, O.

    1995-01-01

    We perform a perturbative analysis of the non-Abelian Aharonov-Bohm problem to one loop in the framework of a local field theory, and show the necessity of contact interactions for renormalizability of perturbation theory. Moreover at critical values of the contact interaction strength the theory is finite and preserves classical conformal invariance

  17. Process for computing geometric perturbations for probabilistic analysis

    Fitch, Simeon H. K. [Charlottesville, VA; Riha, David S [San Antonio, TX; Thacker, Ben H [San Antonio, TX

    2012-04-10

    A method for computing geometric perturbations for probabilistic analysis. The probabilistic analysis is based on finite element modeling, in which uncertainties in the modeled system are represented by changes in the nominal geometry of the model, referred to as "perturbations". These changes are accomplished using displacement vectors, which are computed for each node of a region of interest and are based on mean-value coordinate calculations.

  18. Painleve analysis, conservation laws, and symmetry of perturbed nonlinear equations

    Basak, S.; Chowdhury, A.R.

    1987-01-01

    The authors consider the Lie-Backlund symmetries and conservation laws of a perturbed KdV equation and NLS equation. The arbitrary coefficients of the perturbing terms can be related to the condition of existence of nontrivial LB symmetry generators. When the perturbed KdV equation is subjected to Painleve analysis a la Weiss, it is found that the resonance position changes compared to the unperturbed one. They prove the compatibility of the overdetermined set of equations obtained at the different stages of recursion relations, at least for one branch. All other branches are also indicated and difficulties associated them are discussed considering the perturbation parameter epsilon to be small. They determine the Lax pair for the aforesaid branch through the use of Schwarzian derivative. For the perturbed NLS equation they determine the conservation laws following the approach of Chen and Liu. From the recurrence of these conservation laws a Lax pair is constructed. But the Painleve analysis does not produce a positive answer for the perturbed NLS equation. So here they have two contrasting examples of perturbed nonlinear equations: one passes the Painleve test and its Lax pair can be found from the analysis itself, but the other equation does not meet the criterion of the Painleve test, though its Lax pair is found in another way

  19. Perturbative analysis for Kaplan's lattice chiral fermions

    Aoki, S.; Hirose, H.

    1994-01-01

    Perturbation theory for lattice fermions with domain wall mass terms is developed and is applied to investigate the chiral Schwinger model formulated on the lattice by Kaplan's method. We calculate the effective action for gauge fields to one loop, and find that it contains a longitudinal component even for anomaly-free cases. From the effective action we obtain gauge anomalies and Chern-Simons currents without ambiguity. We also show that the current corresponding to the fermion number has a nonzero divergence and it flows off the wall into the extra dimension. Similar results are obtained for a proposal by Shamir, who used a constant mass term with free boundaries instead of domain walls

  20. NEXCADE: perturbation analysis for complex networks.

    Gitanjali Yadav

    Full Text Available Recent advances in network theory have led to considerable progress in our understanding of complex real world systems and their behavior in response to external threats or fluctuations. Much of this research has been invigorated by demonstration of the 'robust, yet fragile' nature of cellular and large-scale systems transcending biology, sociology, and ecology, through application of the network theory to diverse interactions observed in nature such as plant-pollinator, seed-dispersal agent and host-parasite relationships. In this work, we report the development of NEXCADE, an automated and interactive program for inducing disturbances into complex systems defined by networks, focusing on the changes in global network topology and connectivity as a function of the perturbation. NEXCADE uses a graph theoretical approach to simulate perturbations in a user-defined manner, singly, in clusters, or sequentially. To demonstrate the promise it holds for broader adoption by the research community, we provide pre-simulated examples from diverse real-world networks including eukaryotic protein-protein interaction networks, fungal biochemical networks, a variety of ecological food webs in nature as well as social networks. NEXCADE not only enables network visualization at every step of the targeted attacks, but also allows risk assessment, i.e. identification of nodes critical for the robustness of the system of interest, in order to devise and implement context-based strategies for restructuring a network, or to achieve resilience against link or node failures. Source code and license for the software, designed to work on a Linux-based operating system (OS can be downloaded at http://www.nipgr.res.in/nexcade_download.html. In addition, we have developed NEXCADE as an OS-independent online web server freely available to the scientific community without any login requirement at http://www.nipgr.res.in/nexcade.html.

  1. Customer-oriented finite perturbation analysis for queueing networks

    Heidergott, B.F.

    2000-01-01

    We consider queueing networks for which the performance measureJ ( ) depends on a parameter , which can be a service time parameter or a buffer size, and we are interested in sensitivity analysis of J ( ) with respect to . We introduce a new method, called customer-oriented finite perturbation

  2. Singular perturbation analysis of relaxation oscillations in reactor systems

    Ward, M.E.; Lee, J.C.

    1987-01-01

    A singular perturbation method for the analysis of large power oscillations in nuclear reactors is applied to obtain phase-plane solutions of the Ergen-Weinberg model. The system equations, recast in an appropriate form, directly give a first approximation to the closed trajectory in which the system behaviour is idealized as relaxation oscillations. Further approximations in the phase plane are determined using separate perturbation series on individual parts of the oscillation, with variations in the assignment of dependent and independent variables to consistently obtain convergent series. The accuracy of each order of the phase-plane solution increases with the magnitude of the power pulse in the actual physical situation. For realistic reactor conditions, both the trajectory and period of oscillation are well predicted using the first two terms of each perturbation series

  3. Implementation of the NMR CHEmical Shift Covariance Analysis (CHESCA): A Chemical Biologist's Approach to Allostery.

    Boulton, Stephen; Selvaratnam, Rajeevan; Ahmed, Rashik; Melacini, Giuseppe

    2018-01-01

    Mapping allosteric sites is emerging as one of the central challenges in physiology, pathology, and pharmacology. Nuclear Magnetic Resonance (NMR) spectroscopy is ideally suited to map allosteric sites, given its ability to sense at atomic resolution the dynamics underlying allostery. Here, we focus specifically on the NMR CHEmical Shift Covariance Analysis (CHESCA), in which allosteric systems are interrogated through a targeted library of perturbations (e.g., mutations and/or analogs of the allosteric effector ligand). The atomic resolution readout for the response to such perturbation library is provided by NMR chemical shifts. These are then subject to statistical correlation and covariance analyses resulting in clusters of allosterically coupled residues that exhibit concerted responses to the common set of perturbations. This chapter provides a description of how each step in the CHESCA is implemented, starting from the selection of the perturbation library and ending with an overview of different clustering options.

  4. Simulated shift work in rats perturbs multiscale regulation of locomotor activity

    Hsieh, Wan-Hsin; Escobar, Carolina; Yugay, Tatiana; Lo, Men-Tzung; Pittman-Polletta, Benjamin; Salgado-Delgado, Roberto; Scheer, Frank A. J. L.; Shea, Steven A.; Buijs, Ruud M.; Hu, Kun

    2014-01-01

    Motor activity possesses a multiscale regulation that is characterized by fractal activity fluctuations with similar structure across a wide range of timescales spanning minutes to hours. Fractal activity patterns are disturbed in animals after ablating the master circadian pacemaker (suprachiasmatic nucleus, SCN) and in humans with SCN dysfunction as occurs with aging and in dementia, suggesting the crucial role of the circadian system in the multiscale activity regulation. We hypothesized that the normal synchronization between behavioural cycles and the SCN-generated circadian rhythms is required for multiscale activity regulation. To test the hypothesis, we studied activity fluctuations of rats in a simulated shift work protocol that was designed to force animals to be active during the habitual resting phase of the circadian/daily cycle. We found that these animals had gradually decreased mean activity level and reduced 24-h activity rhythm amplitude, indicating disturbed circadian and behavioural cycles. Moreover, these animals had disrupted fractal activity patterns as characterized by more random activity fluctuations at multiple timescales from 4 to 12 h. Intriguingly, these activity disturbances exacerbated when the shift work schedule lasted longer and persisted even in the normal days (without forced activity) following the shift work. The disrupted circadian and fractal patterns resemble those of SCN-lesioned animals and of human patients with dementia, suggesting a detrimental impact of shift work on multiscale activity regulation. PMID:24829282

  5. Computational singular perturbation analysis of stochastic chemical systems with stiffness

    Wang, Lijin; Han, Xiaoying; Cao, Yanzhao; Najm, Habib N.

    2017-04-01

    Computational singular perturbation (CSP) is a useful method for analysis, reduction, and time integration of stiff ordinary differential equation systems. It has found dominant utility, in particular, in chemical reaction systems with a large range of time scales at continuum and deterministic level. On the other hand, CSP is not directly applicable to chemical reaction systems at micro or meso-scale, where stochasticity plays an non-negligible role and thus has to be taken into account. In this work we develop a novel stochastic computational singular perturbation (SCSP) analysis and time integration framework, and associated algorithm, that can be used to not only construct accurately and efficiently the numerical solutions to stiff stochastic chemical reaction systems, but also analyze the dynamics of the reduced stochastic reaction systems. The algorithm is illustrated by an application to a benchmark stochastic differential equation model, and numerical experiments are carried out to demonstrate the effectiveness of the construction.

  6. A non-perturbative analysis in finite volume gauge theory

    Koller, J.; State Univ. of New York, Stony Brook; Van Baal, P.; State Univ. of New York, Stony Brook

    1988-01-01

    We discuss SU(2) gauge theory on a three-torus using a finite volume expansion. Our discovery of natural coordinates allows us to obtain continuum results in a region where Monte Carlo data are also available. The obtained results agree well with the perturbative and semiclassical analysis for small volumes, and there is fair agreement with the Monte Carlo results in intermediate volumes. The simple picture which emerges for the approximate low energy dynamics is that of three interacting particles enclosed in a sphere, with zero total 'angular momentum'. The validity of an adiabatic approximation is investigated. The fundamentally new understanding gained, is that non-perturbative dynamics can be incorporated by imposing boundary conditions which arise through the nontrivial topology of configuration space. (orig.)

  7. Perturbative analysis of transport and fluctuation studies on RFX

    Martini, S.

    2002-01-01

    On the RFX reversed field pinch different transport mechanisms govern the centre and the edge of the plasma. Core transport is driven by parallel transport in a stochastic magnetic field, giving rise to an outward directed particle convection velocity. At the edge, roughly corresponding to the region outside the toroidal field reversal surface (where q=0), electrostatic fluctuations are an important loss channel, but more than 50% of the power losses have been associated to localized plasma-wall interaction due to the non-axisymmetric magnetic perturbations caused by locked modes. In the paper we present the most recent progress made in the modeling and understanding of the above mechanisms underlying particle and energy transport. The paper also discusses the correlations between core and edge transport phenomena. The main tools are perturbative transport studies by pellet injection and the analysis of the contribution of intermittency processes to particle transport in the edge. (author)

  8. Unmatched Projector/Backprojector Pairs: Perturbation and Convergence Analysis

    Elfving, Tommy; Hansen, Per Christian

    2018-01-01

    are not each other's transpose. Surprisingly, the influence of such errors in algebraic iterative reconstruction methods has received little attention in the literature. The goal of this paper is to perform a rigorous first-order perturbation analysis of the minimization problems underlying the algebraic...... methods in order to understand the role played by the nonmatch of the matrices. We also study the convergence properties of linear stationary iterations based on unmatched matrix pairs, leading to insight into the behavior of some important row-and column-oriented algebraic iterative methods. We conclude...

  9. Beyond perturbation introduction to the homotopy analysis method

    Liao, Shijun

    2003-01-01

    Solving nonlinear problems is inherently difficult, and the stronger the nonlinearity, the more intractable solutions become. Analytic approximations often break down as nonlinearity becomes strong, and even perturbation approximations are valid only for problems with weak nonlinearity.This book introduces a powerful new analytic method for nonlinear problems-homotopy analysis-that remains valid even with strong nonlinearity. In Part I, the author starts with a very simple example, then presents the basic ideas, detailed procedures, and the advantages (and limitations) of homotopy analysis. Part II illustrates the application of homotopy analysis to many interesting nonlinear problems. These range from simple bifurcations of a nonlinear boundary-value problem to the Thomas-Fermi atom model, Volterra''s population model, Von Kármán swirling viscous flow, and nonlinear progressive waves in deep water.Although the homotopy analysis method has been verified in a number of prestigious journals, it has yet to be ...

  10. Application of functional analysis to perturbation theory of differential equations. [nonlinear perturbation of the harmonic oscillator

    Bogdan, V. M.; Bond, V. B.

    1980-01-01

    The deviation of the solution of the differential equation y' = f(t, y), y(O) = y sub O from the solution of the perturbed system z' = f(t, z) + g(t, z), z(O) = z sub O was investigated for the case where f and g are continuous functions on I x R sup n into R sup n, where I = (o, a) or I = (o, infinity). These functions are assumed to satisfy the Lipschitz condition in the variable z. The space Lip(I) of all such functions with suitable norms forms a Banach space. By introducing a suitable norm in the space of continuous functions C(I), introducing the problem can be reduced to an equivalent problem in terminology of operators in such spaces. A theorem on existence and uniqueness of the solution is presented by means of Banach space technique. Norm estimates on the rate of growth of such solutions are found. As a consequence, estimates of deviation of a solution due to perturbation are obtained. Continuity of the solution on the initial data and on the perturbation is established. A nonlinear perturbation of the harmonic oscillator is considered a perturbation of equations of the restricted three body problem linearized at libration point.

  11. Exact Controllability and Perturbation Analysis for Elastic Beams

    Moreles, Miguel Angel

    2004-01-01

    The Rayleigh beam is a perturbation of the Bernoulli-Euler beam. We establish convergence of the solution of the Exact Controllability Problem for the Rayleigh beam to the corresponding solution of the Bernoulli-Euler beam. Convergence is related to a Singular Perturbation Problem. The main tool in solving this perturbation problem is a weak version of a lower bound for hyperbolic polynomials

  12. Multigroup perturbation model for kinetic analysis of nuclear reactors

    Souza, G.M.

    1989-01-01

    The scope of this work is the development of a multigroup perturbation theory for the purpose of Kinetic and dynamic analysis of nuclear reactors. The equations that describe the reactor behavior were presented in all generality and written in the shorthand notation of matrices and vectors. In the derivation of those equations indetermined operators and discretizing factors were introduced and then determined by comparision with conventional equations. Fick's Law was developed in higher orders for neutron and importance current density. The solution of the direct and adjoint fields were represented by combination of the eigenfunctions of the B and B* operators and the eigenvalue modulus equality was established mathematically. In the derivation of the reactivity expression the B operator perturbation was split in two non coupled to the flux form and level. The prompt neutrons effective mean life was derived from reactor equations and importance conservation. The establishment of the Nordheim's equation, although modified, was based on Gandini. Finally, a mathematical interpretation of the flux-trap region was avented. (author)

  13. Perturbation analysis of complete synchronization in networks of phase oscillators.

    Tönjes, Ralf; Blasius, Bernd

    2009-08-01

    The behavior of weakly coupled self-sustained oscillators can often be well described by phase equations. Here we use the paradigm of Kuramoto phase oscillators which are coupled in a network to calculate first- and second-order corrections to the frequency of the fully synchronized state for nonidentical oscillators. The topology of the underlying coupling network is reflected in the eigenvalues and eigenvectors of the network Laplacian which influence the synchronization frequency in a particular way. They characterize the importance of nodes in a network and the relations between them. Expected values for the synchronization frequency are obtained for oscillators with quenched random frequencies on a class of scale-free random networks and for a Erdös-Rényi random network. We briefly discuss an application of the perturbation theory in the second order to network structural analysis.

  14. Analysis of Errors in a Special Perturbations Satellite Orbit Propagator

    Beckerman, M.; Jones, J.P.

    1999-02-01

    We performed an analysis of error densities for the Special Perturbations orbit propagator using data for 29 satellites in orbits of interest to Space Shuttle and International Space Station collision avoidance. We find that the along-track errors predominate. These errors increase monotonically over each 36-hour prediction interval. The predicted positions in the along-track direction progressively either leap ahead of or lag behind the actual positions. Unlike the along-track errors the radial and cross-track errors oscillate about their nearly zero mean values. As the number of observations per fit interval decline the along-track prediction errors, and amplitudes of the radial and cross-track errors, increase.

  15. Recursive Principal Components Analysis Using Eigenvector Matrix Perturbation

    Deniz Erdogmus

    2004-10-01

    Full Text Available Principal components analysis is an important and well-studied subject in statistics and signal processing. The literature has an abundance of algorithms for solving this problem, where most of these algorithms could be grouped into one of the following three approaches: adaptation based on Hebbian updates and deflation, optimization of a second-order statistical criterion (like reconstruction error or output variance, and fixed point update rules with deflation. In this paper, we take a completely different approach that avoids deflation and the optimization of a cost function using gradients. The proposed method updates the eigenvector and eigenvalue matrices simultaneously with every new sample such that the estimates approximately track their true values as would be calculated from the current sample estimate of the data covariance matrix. The performance of this algorithm is compared with that of traditional methods like Sanger's rule and APEX, as well as a structurally similar matrix perturbation-based method.

  16. Acoustofluidics 13: Analysis of acoustic streaming by perturbation methods.

    Sadhal, S S

    2012-07-07

    In this Part 13 of the tutorial series "Acoustofluidics--exploiting ultrasonic standing waves forces and acoustic streaming in microfluidic systems for cell and particle manipulation," the streaming phenomenon is presented from an analytical standpoint, and perturbation methods are developed for analyzing such flows. Acoustic streaming is the phenomenon that takes place when a steady flow field is generated by the absorption of an oscillatory field. This can happen either by attenuation (quartz wind) or by interaction with a boundary. The latter type of streaming can also be generated by an oscillating solid in an otherwise still fluid medium or vibrating enclosure of a fluid body. While we address the first kind of streaming, our focus is largely on the second kind from a practical standpoint for application to microfluidic systems. In this Focus article, we limit the analysis to one- and two-dimensional problems in order to understand the analytical techniques with examples that most-easily illustrate the streaming phenomenon.

  17. Stability Analysis of Nonuniform Rectangular Beams Using Homotopy Perturbation Method

    Seval Pinarbasi

    2012-01-01

    Full Text Available The design of slender beams, that is, beams with large laterally unsupported lengths, is commonly controlled by stability limit states. Beam buckling, also called “lateral torsional buckling,” is different from column buckling in that a beam not only displaces laterally but also twists about its axis during buckling. The coupling between twist and lateral displacement makes stability analysis of beams more complex than that of columns. For this reason, most of the analytical studies in the literature on beam stability are concentrated on simple cases: uniform beams with ideal boundary conditions and simple loadings. This paper shows that complex beam stability problems, such as lateral torsional buckling of rectangular beams with variable cross-sections, can successfully be solved using homotopy perturbation method (HPM.

  18. Fast dynamics perturbation analysis for prediction of protein functional sites

    Cohn Judith D

    2008-01-01

    Full Text Available Abstract Background We present a fast version of the dynamics perturbation analysis (DPA algorithm to predict functional sites in protein structures. The original DPA algorithm finds regions in proteins where interactions cause a large change in the protein conformational distribution, as measured using the relative entropy Dx. Such regions are associated with functional sites. Results The Fast DPA algorithm, which accelerates DPA calculations, is motivated by an empirical observation that Dx in a normal-modes model is highly correlated with an entropic term that only depends on the eigenvalues of the normal modes. The eigenvalues are accurately estimated using first-order perturbation theory, resulting in a N-fold reduction in the overall computational requirements of the algorithm, where N is the number of residues in the protein. The performance of the original and Fast DPA algorithms was compared using protein structures from a standard small-molecule docking test set. For nominal implementations of each algorithm, top-ranked Fast DPA predictions overlapped the true binding site 94% of the time, compared to 87% of the time for original DPA. In addition, per-protein recall statistics (fraction of binding-site residues that are among predicted residues were slightly better for Fast DPA. On the other hand, per-protein precision statistics (fraction of predicted residues that are among binding-site residues were slightly better using original DPA. Overall, the performance of Fast DPA in predicting ligand-binding-site residues was comparable to that of the original DPA algorithm. Conclusion Compared to the original DPA algorithm, the decreased run time with comparable performance makes Fast DPA well-suited for implementation on a web server and for high-throughput analysis.

  19. Perturbation analysis for Monte Carlo continuous cross section models

    Kennedy, Chris B.; Abdel-Khalik, Hany S.

    2011-01-01

    Sensitivity analysis, including both its forward and adjoint applications, collectively referred to hereinafter as Perturbation Analysis (PA), is an essential tool to complete Uncertainty Quantification (UQ) and Data Assimilation (DA). PA-assisted UQ and DA have traditionally been carried out for reactor analysis problems using deterministic as opposed to stochastic models for radiation transport. This is because PA requires many model executions to quantify how variations in input data, primarily cross sections, affect variations in model's responses, e.g. detectors readings, flux distribution, multiplication factor, etc. Although stochastic models are often sought for their higher accuracy, their repeated execution is at best computationally expensive and in reality intractable for typical reactor analysis problems involving many input data and output responses. Deterministic methods however achieve computational efficiency needed to carry out the PA analysis by reducing problem dimensionality via various spatial and energy homogenization assumptions. This however introduces modeling error components into the PA results which propagate to the following UQ and DA analyses. The introduced errors are problem specific and therefore are expected to limit the applicability of UQ and DA analyses to reactor systems that satisfy the introduced assumptions. This manuscript introduces a new method to complete PA employing a continuous cross section stochastic model and performed in a computationally efficient manner. If successful, the modeling error components introduced by deterministic methods could be eliminated, thereby allowing for wider applicability of DA and UQ results. Two MCNP models demonstrate the application of the new method - a Critical Pu Sphere (Jezebel), a Pu Fast Metal Array (Russian BR-1). The PA is completed for reaction rate densities, reaction rate ratios, and the multiplication factor. (author)

  20. Singular Perturbation Analysis and Gene Regulatory Networks with Delay

    Shlykova, Irina; Ponosov, Arcady

    2009-09-01

    There are different ways of how to model gene regulatory networks. Differential equations allow for a detailed description of the network's dynamics and provide an explicit model of the gene concentration changes over time. Production and relative degradation rate functions used in such models depend on the vector of steeply sloped threshold functions which characterize the activity of genes. The most popular example of the threshold functions comes from the Boolean network approach, where the threshold functions are given by step functions. The system of differential equations becomes then piecewise linear. The dynamics of this system can be described very easily between the thresholds, but not in the switching domains. For instance this approach fails to analyze stationary points of the system and to define continuous solutions in the switching domains. These problems were studied in [2], [3], but the proposed model did not take into account a time delay in cellular systems. However, analysis of real gene expression data shows a considerable number of time-delayed interactions suggesting that time delay is essential in gene regulation. Therefore, delays may have a great effect on the dynamics of the system presenting one of the critical factors that should be considered in reconstruction of gene regulatory networks. The goal of this work is to apply the singular perturbation analysis to certain systems with delay and to obtain an analog of Tikhonov's theorem, which provides sufficient conditions for constracting the limit system in the delay case.

  1. Perturbative analysis of multiple-field cosmological inflation

    Lahiri, Joydev; Bhattacharya, Gautam

    2006-01-01

    We develop a general formalism for analyzing linear perturbations in multiple-field cosmological inflation based on the gauge-ready approach. Our inflationary model consists of an arbitrary number of scalar fields with non-minimal kinetic terms. We solve the equations for scalar- and tensor-type perturbations during inflation to the first order in slow roll, and then obtain the super-horizon solutions for adiabatic and isocurvature perturbations after inflation. Analytic expressions for power-spectra and spectral indices arising from multiple-field inflation are presented

  2. Perturbation method for fuel evolution and shuffling analysis

    Gandini, A.

    1987-01-01

    A perturbation methodology is described by which the behaviour of a reactor system during burnup can be analyzed making use of Generalized Perturbation Theory (GPT) codes already available in the linear domain. Typical quantities that can be studied with the proposed methodology are the amount of a specified material at the end of cycle, the fluence in a specified region, the residual reactivity at end of reactor life cycle. The potentiality of the method for fuel shuffling studies is also described. (author)

  3. Perturbation Method of Analysis Applied to Substitution Measurements of Buckling

    Persson, Rolf

    1966-11-15

    Calculations with two-group perturbation theory on substitution experiments with homogenized regions show that a condensation of the results into a one-group formula is possible, provided that a transition region is introduced in a proper way. In heterogeneous cores the transition region comes in as a consequence of a new cell concept. By making use of progressive substitutions the properties of the transition region can be regarded as fitting parameters in the evaluation procedure. The thickness of the region is approximately equal to the sum of 1/(1/{tau} + 1/L{sup 2}){sup 1/2} for the test and reference regions. Consequently a region where L{sup 2} >> {tau}, e.g. D{sub 2}O, contributes with {radical}{tau} to the thickness. In cores where {tau} >> L{sup 2} , e.g. H{sub 2}O assemblies, the thickness of the transition region is determined by L. Experiments on rod lattices in D{sub 2}O and on test regions of D{sub 2}O alone (where B{sup 2} = - 1/L{sup 2} ) are analysed. The lattice measurements, where the pitches differed by a factor of {radical}2, gave excellent results, whereas the determination of the diffusion length in D{sub 2}O by this method was not quite successful. Even regions containing only one test element can be used in a meaningful way in the analysis.

  4. Perturbative quantum chromodynamic analysis of deep inelastic scattering

    Herrod, R.T.

    1982-01-01

    This is an account of the field theoretic description of the deep inelastic scattering of leptons from nucleons. Starting from simple parton model description, using the assumption of an SU(3) colour confining field theory, for the quarks comprising hadronic matter, the well known prediction of Bjorken scaling is obtained. Field theoretic predictions for deviations from Bjorken scaling are formally introduced, with particular reference to quantum chromodynamics (QCD). This treatment is purely perturbative, although the renormalisation group is used to improve convergence. Scaling violations at both leading order, and next-to-leading order are discussed, and it is shown how these lead to predictions regarding the dependence of the moments of observable structure functions, on the square of the 4-momentum transferred (Q 2 ). Evolution equations for the moments of structure functions are then derived. The intuitive approach of Altarelli and Parisi (AP), which leads to predictions for the Q 2 dependence of the structure functions themselves, is introduced. The corresponding equations are derived to next-to-leading order. The results of an extensive analysis of current data are presented.. Both weak and electromagnetic structure functions are compared with the predictions of leading order, and higher order formulae. Methods for incorporating heavy quark flavours into the AP equations are discussed. (author)

  5. Shift Performance Test and Analysis of Multipurpose Vehicle

    Can Yang

    2014-08-01

    Full Text Available This paper presented an analysis of the gear shifting performances of a multipurpose vehicle transmission in driving condition by Ricardo's Gear Shift Quality Assessment (GSQA system. The performances of the transmission included the travel and effort of the gear shift lever and synchronizing time. The mathematic models of the transmission including the gear shift mechanism and synchronizer were developed in MATLAB. The model of the gear shift mechanism was developed to analyze the travel map of the gear shift lever and the model of the synchronizer was developed to obtain the force-time curve of the synchronizer during the slipping time. The model of the synchronizer was used to investigate the relationship between the performances of the transmission and the variation of parameters during gear shifting. The mathematic models of the gear shift mechanism and the synchronizer provided a rapid design and verification method for the transmission with ring spring.

  6. An analysis of the expected eccentricity perturbations for the second Radio Astronomy Explorer (RAE B)

    Murphy, J. P.

    1972-01-01

    Analytical prediction of expected eccentricity perturbations for the RAE 2 lunar orbit shows that the eccentricity will grow linearly in time. Parametric inclination studies and analysis of perturbation equations establish a critical retrograde inclination of 116.565 at which the positive perturbation slope vanishes for a circular orbit about 1100 m above the lunar surface with an eccentricity constraint of less than 0.005 during a period of about one year.

  7. Geometric singular perturbation analysis of systems with friction

    Bossolini, Elena

    This thesis is concerned with the application of geometric singular perturbation theory to mechanical systems with friction. The mathematical background on geometric singular perturbation theory, on the blow-up method, on non-smooth dynamical systems and on regularization is presented. Thereafter......, two mechanical problems with two different formulations of the friction force are introduced and analysed. The first mechanical problem is a one-dimensional spring-block model describing earthquake faulting. The dynamics of earthquakes is naturally a multiple timescale problem: the timescale...... scales. The action of friction is generally explained as the loss and restoration of linkages between the surface asperities at the molecular scale. However, the consequences of friction are noticeable at much larger scales, like hundreds of kilometers. By using geometric singular perturbation theory...

  8. Analysis of observables in Chern-Simons perturbation theory

    Alvarez, M.; Labastida, J.M.F.

    1993-01-01

    Chern-Simons theory with gauge group SU(N) is analyzed from a perturbation theory point of view. Computations up to order g 6 of the vacuum expectation value of the unknot are carried out and it is shown that agreement with the exact result by Witten implies no quantum correction at two loops for the two-point function. In addition, it is shown from a perturbation theory point of view that the framing dependence of the vacuum expectation value of an arbitrary knot factorizes in the form predicted by Witten. (orig.)

  9. Eigenstructure of of singular systems. Perturbation analysis of simple eigenvalues

    García Planas, María Isabel; Tarragona Romero, Sonia

    2014-01-01

    The problem to study small perturbations of simple eigenvalues with a change of parameters is of general interest in applied mathematics. After to introduce a systematic way to know if an eigenvalue of a singular system is simple or not, the aim of this work is to study the behavior of a simple eigenvalue of singular linear system family

  10. Perturbation analysis of a parametrically changed sine-Gordon equation

    Sakai, S.; Samuelsen, Mogens Rugholm; Olsen, O. H.

    1987-01-01

    A long Josephson junction with a spatially varying inductance is a physical manifestation of a modified sine-Gordon equation with parametric perturbation. Soliton propagation in such Josephson junctions is discussed. First, for an adiabatic model where the inductance changes smoothly compared...

  11. Perturbation analysis of the TRIGA Mark II reactor Vienna

    Khan, R. [Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad (Pakistan); Villa, M.; Stummer, T.; Boeck, H. [Vienna Univ. of Technology (Austria). Atominstitut; Saeedbadshah [International Islamic Univ., Islamabad (Pakistan)

    2013-04-15

    The safety design of a nuclear reactor needs to maintain the steady state operation at desired power level. The safe and reliable reactor operation demands the complete knowledge of the core multiplication and its changes during the reactor operation. Therefore it is frequently of interest to compute the changes in core multiplication caused by small disturbances in the field of reactor physics. These disturbances can be created either by geometry or composition changes of the core. Fortunately if these changes (or perturbations) are very small, one does not have to repeat the reactivity calculations. This article focuses the study of small perturbations created in the Central Irradiation Channel (CIC) of the TRIGA mark II core to investigate their reactivity influences on the core reactivity. For this purpose, 3 different kinds of perturbations are created by inserting 3 different samples in the CIC. The cylindrical void (air), heavy water (D2O) and Cadmium (Cd) samples are inserted into the CIC separately to determine their neutronics behavior along the length of the core. The Monte Carlo N-Particle radiation transport code (MCNP) is applied to simulate these perturbations in the CIC. The MCNP theoretical predictions are verified by the experiments performed on the current reactor core. The behavior of void in the whole core and its dependence on position and water fraction is also presented in this article. (orig.)

  12. Qualitative dynamical analysis of chaotic plasma perturbations model

    Elsadany, A. A.; Elsonbaty, Amr; Agiza, H. N.

    2018-06-01

    In this work, an analytical framework to understand nonlinear dynamics of plasma perturbations model is introduced. In particular, we analyze the model presented by Constantinescu et al. [20] which consists of three coupled ODEs and contains three parameters. The basic dynamical properties of the system are first investigated by the ways of bifurcation diagrams, phase portraits and Lyapunov exponents. Then, the normal form technique and perturbation methods are applied so as to the different types of bifurcations that exist in the model are investigated. It is proved that pitcfork, Bogdanov-Takens, Andronov-Hopf bifurcations, degenerate Hopf and homoclinic bifurcation can occur in phase space of the model. Also, the model can exhibit quasiperiodicity and chaotic behavior. Numerical simulations confirm our theoretical analytical results.

  13. A numerical scheme for singularly perturbed reaction-diffusion problems with a negative shift via numerov method

    Dinesh Kumar, S.; Nageshwar Rao, R.; Pramod Chakravarthy, P.

    2017-11-01

    In this paper, we consider a boundary value problem for a singularly perturbed delay differential equation of reaction-diffusion type. We construct an exponentially fitted numerical method using Numerov finite difference scheme, which resolves not only the boundary layers but also the interior layers arising from the delay term. An extensive amount of computational work has been carried out to demonstrate the applicability of the proposed method.

  14. Guidelines for secondary analysis in search of response shift

    Schwartz, Carolyn E.; Ahmed, Sara; Sawatzky, Richard; Sajobi, Tolulope; Mayo, Nancy; Finkelstein, Joel; Lix, Lisa; Verdam, Mathilde G. E.; Oort, Frans J.; Sprangers, Mirjam A. G.

    2013-01-01

    Response shift methods have developed substantially in the past decade, with a notable emphasis on model-based methods for response shift detection that are appropriate for the analysis of existing data sets. These secondary data analyses have yielded useful insights and motivated the continued

  15. Guidelines for secondary analysis in search of response shift

    Schwartz, C.E.; Ahmed, S.; Sawatzky, R.; Sajobi, T.; Mayo, N.; Finkelstein, J.; Verdam, M.G.E.; Oort, F.J.; Sprangers, M.A.G.

    2013-01-01

    Objective: Response shift methods have developed substantially in the past decade, with a notable emphasis on model-based methods for response shift detection that are appropriate for the analysis of existing data sets. These secondary data analyses have yielded useful insights and motivated the

  16. Solid-state NMR chemical-shift perturbations indicate domain reorientation of the DnaG primase in the primosome of Helicobacter pylori

    Gardiennet, Carole [Université de Lorraine, CNRS, CRM2, UMR 7036 (France); Wiegand, Thomas [ETH Zurich, Physical Chemistry (Switzerland); Bazin, Alexandre [Université de Lyon 1, Molecular Microbiology and Structural Biochemistry, Labex Ecofect, UMR 5086 CNRS (France); Cadalbert, Riccardo [ETH Zurich, Physical Chemistry (Switzerland); Kunert, Britta; Lacabanne, Denis [Université de Lyon 1, Molecular Microbiology and Structural Biochemistry, Labex Ecofect, UMR 5086 CNRS (France); Gutsche, Irina [Université Grenoble Alpes, Institut de Biologie Structurale (IBS), CNRS, IBS, CEA, IBS (France); Terradot, Laurent, E-mail: l.terradot@ibcp.fr [Université de Lyon 1, Molecular Microbiology and Structural Biochemistry, Labex Ecofect, UMR 5086 CNRS (France); Meier, Beat H., E-mail: beme@ethz.ch [ETH Zurich, Physical Chemistry (Switzerland); Böckmann, Anja, E-mail: a.bockmann@ibcp.fr [Université de Lyon 1, Molecular Microbiology and Structural Biochemistry, Labex Ecofect, UMR 5086 CNRS (France)

    2016-03-15

    We here investigate the interactions between the DnaB helicase and the C-terminal domain of the corresponding DnaG primase of Helicobacter pylori using solid-state NMR. The difficult crystallization of this 387 kDa complex, where the two proteins interact in a six to three ratio, is circumvented by simple co-sedimentation of the two proteins directly into the MAS-NMR rotor. While the amount of information that can be extracted from such a large protein is still limited, we can assign a number of amino-acid residues experiencing significant chemical-shift perturbations upon helicase-primase complex formation. The location of these residues is used as a guide to model the interaction interface between the two proteins in the complex. Chemical-shift perturbations also reveal changes at the interaction interfaces of the hexameric HpDnaB assembly on HpDnaG binding. A structural model of the complex that explains the experimental findings is obtained.

  17. Control system analysis for the perturbed linear accelerator rf system

    Sung Il Kwon

    2002-01-01

    This paper addresses the modeling problem of the linear accelerator RF system in SNS. Klystrons are modeled as linear parameter varying systems. The effect of the high voltage power supply ripple on the klystron output voltage and the output phase is modeled as an additive disturbance. The cavity is modeled as a linear system and the beam current is modeled as the exogenous disturbance. The output uncertainty of the low level RF system which results from the uncertainties in the RF components and cabling is modeled as multiplicative uncertainty. Also, the feedback loop uncertainty and digital signal processing signal conditioning subsystem uncertainties are lumped together and are modeled as multiplicative uncertainty. Finally, the time delays in the loop are modeled as a lumped time delay. For the perturbed open loop system, the closed loop system performance, and stability are analyzed with the PI feedback controller.

  18. CONTROL SYSTEM ANALYSIS FOR THE PERTURBED LINEAR ACCELERATOR RF SYSTEM

    SUNG-IL KWON; AMY H. REGAN

    2002-01-01

    This paper addresses the modeling problem of the linear accelerator RF system in SNS. Klystrons are modeled as linear parameter varying systems. The effect of the high voltage power supply ripple on the klystron output voltage and the output phase is modeled as an additive disturbance. The cavity is modeled as a linear system and the beam current is modeled as the exogenous disturbance. The output uncertainty of the low level RF system which results from the uncertainties in the RF components and cabling is modeled as multiplicative uncertainty. Also, the feedback loop uncertainty and digital signal processing signal conditioning subsystem uncertainties are lumped together and are modeled as multiplicative uncertainty. Finally, the time delays in the loop are modeled as a lumped time delay. For the perturbed open loop system, the closed loop system performance, and stability are analyzed with the PI feedback controller

  19. SHIFT: server for hidden stops analysis in frame-shifted translation.

    Gupta, Arun; Singh, Tiratha Raj

    2013-02-23

    Frameshift is one of the three classes of recoding. Frame-shifts lead to waste of energy, resources and activity of the biosynthetic machinery. In addition, some peptides synthesized after frame-shifts are probably cytotoxic which serve as plausible cause for innumerable number of diseases and disorders such as muscular dystrophies, lysosomal storage disorders, and cancer. Hidden stop codons occur naturally in coding sequences among all organisms. These codons are associated with the early termination of translation for incorrect reading frame selection and help to reduce the metabolic cost related to the frameshift events. Researchers have identified several consequences of hidden stop codons and their association with myriad disorders. However the wealth of information available is speckled and not effortlessly acquiescent to data-mining. To reduce this gap, this work describes an algorithmic web based tool to study hidden stops in frameshifted translation for all the lineages through respective genetic code systems. This paper describes SHIFT, an algorithmic web application tool that provides a user-friendly interface for identifying and analyzing hidden stops in frameshifted translation of genomic sequences for all available genetic code systems. We have calculated the correlation between codon usage frequencies and the plausible contribution of codons towards hidden stops in an off-frame context. Markovian chains of various order have been used to model hidden stops in frameshifted peptides and their evolutionary association with naturally occurring hidden stops. In order to obtain reliable and persuasive estimates for the naturally occurring and predicted hidden stops statistical measures have been implemented. This paper presented SHIFT, an algorithmic tool that allows user-friendly exploration, analysis, and visualization of hidden stop codons in frameshifted translations. It is expected that this web based tool would serve as a useful complement for

  20. Framework for network modularization and Bayesian network analysis to investigate the perturbed metabolic network

    Kim Hyun

    2011-12-01

    Full Text Available Abstract Background Genome-scale metabolic network models have contributed to elucidating biological phenomena, and predicting gene targets to engineer for biotechnological applications. With their increasing importance, their precise network characterization has also been crucial for better understanding of the cellular physiology. Results We herein introduce a framework for network modularization and Bayesian network analysis (FMB to investigate organism’s metabolism under perturbation. FMB reveals direction of influences among metabolic modules, in which reactions with similar or positively correlated flux variation patterns are clustered, in response to specific perturbation using metabolic flux data. With metabolic flux data calculated by constraints-based flux analysis under both control and perturbation conditions, FMB, in essence, reveals the effects of specific perturbations on the biological system through network modularization and Bayesian network analysis at metabolic modular level. As a demonstration, this framework was applied to the genetically perturbed Escherichia coli metabolism, which is a lpdA gene knockout mutant, using its genome-scale metabolic network model. Conclusions After all, it provides alternative scenarios of metabolic flux distributions in response to the perturbation, which are complementary to the data obtained from conventionally available genome-wide high-throughput techniques or metabolic flux analysis.

  1. Framework for network modularization and Bayesian network analysis to investigate the perturbed metabolic network.

    Kim, Hyun Uk; Kim, Tae Yong; Lee, Sang Yup

    2011-01-01

    Genome-scale metabolic network models have contributed to elucidating biological phenomena, and predicting gene targets to engineer for biotechnological applications. With their increasing importance, their precise network characterization has also been crucial for better understanding of the cellular physiology. We herein introduce a framework for network modularization and Bayesian network analysis (FMB) to investigate organism's metabolism under perturbation. FMB reveals direction of influences among metabolic modules, in which reactions with similar or positively correlated flux variation patterns are clustered, in response to specific perturbation using metabolic flux data. With metabolic flux data calculated by constraints-based flux analysis under both control and perturbation conditions, FMB, in essence, reveals the effects of specific perturbations on the biological system through network modularization and Bayesian network analysis at metabolic modular level. As a demonstration, this framework was applied to the genetically perturbed Escherichia coli metabolism, which is a lpdA gene knockout mutant, using its genome-scale metabolic network model. After all, it provides alternative scenarios of metabolic flux distributions in response to the perturbation, which are complementary to the data obtained from conventionally available genome-wide high-throughput techniques or metabolic flux analysis.

  2. Advantages of shift changeovers with meetings: ergonomic analysis of shift supervisors' activity in aircraft building.

    Le Bris, Valérie; Barthe, Béatrice; Marquié, Jean-Claude; Kerguelen, Alain; Aubert, Sophie; Bernadou, Bernadette

    2012-03-01

    Good shift changeovers contribute to ensuring continuity and reliability in shift work. In situations where production is not maintained 24 h a day, changeovers with meetings (SCM) between the two work teams (written plus oral face-to-face handovers) alternate with changeovers without meetings (SCnM; written handovers only). An ergonomic work analysis on an aircraft assembly line showed that (1) incoming and outgoing operators met during the overlap time allotted by the company, and (2) the content of the exchanges was richer for SCMs than for SCnMs. SCMs enabled the operators to pass on and process more aspects of their work than SCnMs did. SCMs also allowed incoming operators to validate their predictions, and enabled both outgoing and incoming operators to update their mental models and work together on peripheral aspects of the technical process over a greater time span. The findings highlight the importance of allowing overlap time in shift work. Copyright © 2011 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  3. SAMPO: a code system giving different orders of approximation for sensitivity and perturbation analysis

    Estiot, J.C.; Salvatores, M.; Palmiotti, G.

    1981-01-01

    We present the characteristics of SAMPO, a one dimension transport theory code system, which is used for the following types of calculation: sensitivity analysis for functional linear or bi-linear on the direct or adjoint flux and their ratios; classic perturbation analysis. First order calculations, as well higher order, can be presented

  4. Sensitivity analysis of critical experiment with direct perturbation compared to TSUNAMI-3D sensitivity analysis

    Barber, A. D.; Busch, R.

    2009-01-01

    The goal of this work is to obtain sensitivities from direct uncertainty analysis calculation and correlate those calculated values with the sensitivities produced from TSUNAMI-3D (Tools for Sensitivity and Uncertainty Analysis Methodology Implementation in Three Dimensions). A full sensitivity analysis is performed on a critical experiment to determine the overall uncertainty of the experiment. Small perturbation calculations are performed for all known uncertainties to obtain the total uncertainty of the experiment. The results from a critical experiment are only known as well as the geometric and material properties. The goal of this relationship is to simplify the uncertainty quantification process in assessing a critical experiment, while still considering all of the important parameters. (authors)

  5. Reliability importance analysis of Markovian systems at steady state using perturbation analysis

    Phuc Do Van [Institut Charles Delaunay - FRE CNRS 2848, Systems Modeling and Dependability Group, Universite de technologie de Troyes, 12, rue Marie Curie, BP 2060-10010 Troyes cedex (France); Barros, Anne [Institut Charles Delaunay - FRE CNRS 2848, Systems Modeling and Dependability Group, Universite de technologie de Troyes, 12, rue Marie Curie, BP 2060-10010 Troyes cedex (France)], E-mail: anne.barros@utt.fr; Berenguer, Christophe [Institut Charles Delaunay - FRE CNRS 2848, Systems Modeling and Dependability Group, Universite de technologie de Troyes, 12, rue Marie Curie, BP 2060-10010 Troyes cedex (France)

    2008-11-15

    Sensitivity analysis has been primarily defined for static systems, i.e. systems described by combinatorial reliability models (fault or event trees). Several structural and probabilistic measures have been proposed to assess the components importance. For dynamic systems including inter-component and functional dependencies (cold spare, shared load, shared resources, etc.), and described by Markov models or, more generally, by discrete events dynamic systems models, the problem of sensitivity analysis remains widely open. In this paper, the perturbation method is used to estimate an importance factor, called multi-directional sensitivity measure, in the framework of Markovian systems. Some numerical examples are introduced to show why this method offers a promising tool for steady-state sensitivity analysis of Markov processes in reliability studies.

  6. Reliability importance analysis of Markovian systems at steady state using perturbation analysis

    Phuc Do Van; Barros, Anne; Berenguer, Christophe

    2008-01-01

    Sensitivity analysis has been primarily defined for static systems, i.e. systems described by combinatorial reliability models (fault or event trees). Several structural and probabilistic measures have been proposed to assess the components importance. For dynamic systems including inter-component and functional dependencies (cold spare, shared load, shared resources, etc.), and described by Markov models or, more generally, by discrete events dynamic systems models, the problem of sensitivity analysis remains widely open. In this paper, the perturbation method is used to estimate an importance factor, called multi-directional sensitivity measure, in the framework of Markovian systems. Some numerical examples are introduced to show why this method offers a promising tool for steady-state sensitivity analysis of Markov processes in reliability studies

  7. Associations of rotational shift work and night shift status with hypertension: a systematic review and meta-analysis.

    Manohar, Sandhya; Thongprayoon, Charat; Cheungpasitporn, Wisit; Mao, Michael A; Herrmann, Sandra M

    2017-10-01

    The reported risks of hypertension (HTN) in rotating shift and night shift workers are controversial. The objective of this meta-analysis was to assess the association between shift work status and HTN. A literature search was performed using MEDLINE, EMBASE and Cochrane Database from inception through October 2016. Studies that reported odds ratios (OR) comparing the risk of HTN in shift workers were included. A prespecified subgroup analysis by rotating shift and night shift statuses were also performed. Pooled OR and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method. The protocol for this study is registered with International Prospective Register of Systematic Reviews; no. CRD42016051843. Twenty-seven observational studies (nine cohort and 18 cross-sectional studies) with a total of 394 793 individuals were enrolled. The pooled ORs of HTN in shift workers in cohort and cross-sectional studies were 1.31 (95% CI, 1.07-1.60) and 1.10 (95% CI, 1.00-1.20), respectively. When meta-analysis was restricted only to cohort studies in rotating shift, the pooled OR of HTN in rotating shift workers was 1.34 (95% CI, 1.08-1.67). The data regarding night shift and HTN in cohort studies was limited. The pooled OR of HTN in night shift workers in cross-sectional studies was 1.07 (95% CI, 0.85-1.35). Based on the findings of our meta-analysis, shiftwork status may play an important role in HTN, as there is a significant association between rotating shift work and HTN. However, there is no significant association between night shift status and risk of HTN.

  8. A Homotopy-Perturbation analysis of the non-linear contaminant ...

    In this research work, a Homotopy-perturbation analysis of a non –linear contaminant flow equation with an initial continuous point source is provided. The equation is characterized by advection, diffusion and adsorption. We assume that the adsorption term is modeled by Freudlich Isotherm. We provide an approximation of ...

  9. Tapping in synchrony with a perturbed metronome: the phase correction response to small and large phase shifts as a function of tempo.

    Repp, Bruno H

    2011-01-01

    When tapping is paced by an auditory sequence containing small phase shift (PS) perturbations, the phase correction response (PCR) of the tap following a PS increases with the baseline interonset interval (IOI), leading eventually to overcorrection (B. H. Repp, 2008). Experiment 1 shows that this holds even for fixed-size PSs that become imperceptible as the IOI increases (here, from 400 to 1200 ms). Earlier research has also shown (but only for IOI=500 ms) that the PCR is proportionally smaller for large than for small PSs (B. H. Repp, 2002a, 2002b). Experiment 2 introduced large PSs and found smaller PCRs than in Experiment 1, at all of the same IOIs. In Experiments 3A and 3B, the author investigated whether the change in slope of the sigmoid function relating PCR and PS magnitudes occurs at a fixed absolute or relative PS magnitude across different IOIs (600, 1000, 1400 ms). The results suggest no clear answer; the exact shape of the function may depend on the range of PSs used in an experiment. Experiment 4 examined the PCR in the IOI range from 1000 to 2000 ms and found overcorrection throughout, but with the PCR increasing much more gradually than in Experiment 1. These results provide important new information about the phase correction process and pose challenges for models of sensorimotor synchronization, which presently cannot explain nonlinear PCR functions and overcorrection. Copyright © Taylor & Francis Group, LLC

  10. Application of perturbation methods for sensitivity analysis for nuclear power plant steam generators

    Gurjao, Emir Candeia

    1996-02-01

    The differential and GPT (Generalized Perturbation Theory) formalisms of the Perturbation Theory were applied in this work to a simplified U-tubes steam generator model to perform sensitivity analysis. The adjoint and importance equations, with the corresponding expressions for the sensitivity coefficients, were derived for this steam generator model. The system was numerically was numerically solved in a Fortran program, called GEVADJ, in order to calculate the sensitivity coefficients. A transient loss of forced primary coolant in the nuclear power plant Angra-1 was used as example case. The average and final values of functionals: secondary pressure and enthalpy were studied in relation to changes in the secondary feedwater flow, enthalpy and total volume in secondary circuit. Absolute variations in the above functionals were calculated using the perturbative methods, considering the variations in the feedwater flow and total secondary volume. Comparison with the same variations obtained via direct model showed in general good agreement, demonstrating the potentiality of perturbative methods for sensitivity analysis of nuclear systems. (author)

  11. PeTTSy: a computational tool for perturbation analysis of complex systems biology models.

    Domijan, Mirela; Brown, Paul E; Shulgin, Boris V; Rand, David A

    2016-03-10

    Over the last decade sensitivity analysis techniques have been shown to be very useful to analyse complex and high dimensional Systems Biology models. However, many of the currently available toolboxes have either used parameter sampling, been focused on a restricted set of model observables of interest, studied optimisation of a objective function, or have not dealt with multiple simultaneous model parameter changes where the changes can be permanent or temporary. Here we introduce our new, freely downloadable toolbox, PeTTSy (Perturbation Theory Toolbox for Systems). PeTTSy is a package for MATLAB which implements a wide array of techniques for the perturbation theory and sensitivity analysis of large and complex ordinary differential equation (ODE) based models. PeTTSy is a comprehensive modelling framework that introduces a number of new approaches and that fully addresses analysis of oscillatory systems. It examines sensitivity analysis of the models to perturbations of parameters, where the perturbation timing, strength, length and overall shape can be controlled by the user. This can be done in a system-global setting, namely, the user can determine how many parameters to perturb, by how much and for how long. PeTTSy also offers the user the ability to explore the effect of the parameter perturbations on many different types of outputs: period, phase (timing of peak) and model solutions. PeTTSy can be employed on a wide range of mathematical models including free-running and forced oscillators and signalling systems. To enable experimental optimisation using the Fisher Information Matrix it efficiently allows one to combine multiple variants of a model (i.e. a model with multiple experimental conditions) in order to determine the value of new experiments. It is especially useful in the analysis of large and complex models involving many variables and parameters. PeTTSy is a comprehensive tool for analysing large and complex models of regulatory and

  12. Analysis of a renormalization group method and normal form theory for perturbed ordinary differential equations

    DeVille, R. E. Lee; Harkin, Anthony; Holzer, Matt; Josić, Krešimir; Kaper, Tasso J.

    2008-06-01

    For singular perturbation problems, the renormalization group (RG) method of Chen, Goldenfeld, and Oono [Phys. Rev. E. 49 (1994) 4502-4511] has been shown to be an effective general approach for deriving reduced or amplitude equations that govern the long time dynamics of the system. It has been applied to a variety of problems traditionally analyzed using disparate methods, including the method of multiple scales, boundary layer theory, the WKBJ method, the Poincaré-Lindstedt method, the method of averaging, and others. In this article, we show how the RG method may be used to generate normal forms for large classes of ordinary differential equations. First, we apply the RG method to systems with autonomous perturbations, and we show that the reduced or amplitude equations generated by the RG method are equivalent to the classical Poincaré-Birkhoff normal forms for these systems up to and including terms of O(ɛ2), where ɛ is the perturbation parameter. This analysis establishes our approach and generalizes to higher order. Second, we apply the RG method to systems with nonautonomous perturbations, and we show that the reduced or amplitude equations so generated constitute time-asymptotic normal forms, which are based on KBM averages. Moreover, for both classes of problems, we show that the main coordinate changes are equivalent, up to translations between the spaces in which they are defined. In this manner, our results show that the RG method offers a new approach for deriving normal forms for nonautonomous systems, and it offers advantages since one can typically more readily identify resonant terms from naive perturbation expansions than from the nonautonomous vector fields themselves. Finally, we establish how well the solution to the RG equations approximates the solution of the original equations on time scales of O(1/ɛ).

  13. ANALYSIS OF PERTURBED MOTION STABILITY OF WHEELER VEHICLES BRAKES CONTROL SYSTEM

    V. Verbytskiyi

    2011-01-01

    Full Text Available The analysis of the perturbed motion stability of the brake automatic control system on the basis of Lyapunov’s second method is carried out. Using transformations of Lurie there has been ob-tained the canonical form of the system of equations of automatic control. It allowed determining the necessary and sufficient conditions of the asymptotic stability of the system irrespective of its initial condition and a definite choice of the admissible characteristic of the regulator.

  14. The Effect of Different Perturbations on the Stability Analysis of Light Water Reactors

    Dykin, Victor

    2010-09-01

    Neutron noise analysis techniques are studied and developed, with primary use of determining the stability of Boiling Water Reactors (BWRs). In particular, the role of a specific perturbation prevailing in Light Water Reactors, the propagating density perturbation, in the stability of BWRs and on the noise field of LWRs in general, is investigated by considering three topics. In the first topics, we investigate how the neutronic response of the reactor, usually described as a second order system driven by a white noise driving force, is affected by a non-white driving force. This latter arises from the reactivity effect of the propagating density perturbations. The investigation is performed by using spectral and correlation analysis. Propagating perturbations with different velocities are analyzed. We investigate how the accuracy of the determination of the so-called decay ratio (DR) of the system, based on the assumption of white noise driving force, deteriorates with deviations from the white noise character of the driving force. In the second topics, the space dependence of the neutron noise, induced by propagating density perturbations, represented through the perturbation of the absorption, is determined and discussed. A full analytical solution was obtained by the use of the Green's function technique. The solution was analyzed for different frequencies and different system sizes. An interesting new interference effect between the point-kinetic and space-dependent components of the induced noise was discovered and interpreted in physical terms. In the last topics, a non-linear stability analysis of a BWR is performed, using so called Reduced Order Model (ROM) techniques. A ROM is usually constructed by reducing the full set of 3D space-time dependent neutron-kinetics, thermal-hydraulics and heat transfer equations to time-dependent ones, by considering space dependence in a lumped parameter model (one or two discrete channels). The main novelty of our work

  15. An analysis of clock-shift experiments: is scatter increased and deflection reduced in clock-shifted homing pigeons?

    Chappell

    1997-01-01

    Clock-shifting (altering the phase of the internal clock) in homing pigeons leads to a deflection in the vanishing bearing of the clock-shifted group relative to controls. However, two unexplained phenomena are common in clock-shift experiments: the vanishing bearings of the clock-shifted group are often more scattered (with a shorter vector length) than those of the control group, and the deflection of the mean bearing of the clock-shifted group from that of the controls is often smaller than expected theoretically. Here, an analysis of 55 clock-shift experiments performed in four countries over 21 years is reported. The bearings of the clock-shifted groups were significantly more scattered than those of controls and less deflected than expected, but these effects were not significantly different at familiar and unfamiliar sites. The possible causes of the effects are discussed and evaluated with reference to this analysis and other experiments. The most likely causes appear to be conflict between the directions indicated by the sun compass and either unshifted familiar visual landmarks (at familiar sites only) or the unshifted magnetic compass (possible at both familiar and unfamiliar sites).

  16. Automation of peak-tracking analysis of stepwise perturbed NMR spectra

    Banelli, Tommaso; Vuano, Marco [Università di Udine, Dipartimento di Area Medica (Italy); Fogolari, Federico [INBB (Italy); Fusiello, Andrea [Università di Udine, Dipartimento Politecnico di Ingegneria e Architettura (Italy); Esposito, Gennaro [INBB (Italy); Corazza, Alessandra, E-mail: alessandra.corazza@uniud.it [Università di Udine, Dipartimento di Area Medica (Italy)

    2017-02-15

    We describe a new algorithmic approach able to automatically pick and track the NMR resonances of a large number of 2D NMR spectra acquired during a stepwise variation of a physical parameter. The method has been named Trace in Track (TinT), referring to the idea that a gaussian decomposition traces peaks within the tracks recognised through 3D mathematical morphology. It is capable of determining the evolution of the chemical shifts, intensity and linewidths of each tracked peak.The performances obtained in term of track reconstruction and correct assignment on realistic synthetic spectra were high above 90% when a noise level similar to that of experimental data were considered. TinT was applied successfully to several protein systems during a temperature ramp in isotope exchange experiments. A comparison with a state-of-the-art algorithm showed promising results for great numbers of spectra and low signal to noise ratios, when the graduality of the perturbation is appropriate. TinT can be applied to different kinds of high throughput chemical shift mapping experiments, with quasi-continuous variations, in which a quantitative automated recognition is crucial.

  17. Post-Keplerian perturbations of the orbital time shift in binary pulsars: an analytical formulation with applications to the galactic center

    Iorio, Lorenzo [Ministero dell' Istruzione, Univ. Ricerca (M.I.U.R.)-Istruzione, Bari (Italy)

    2017-07-15

    We develop a general approach to analytically calculate the perturbations Δδτ p of the orbital component of the change δτ{sub p} of the times of arrival of the pulses emitted by a binary pulsar p induced by the post-Keplerian accelerations due to the mass quadrupole Q{sub 2}, and the post-Newtonian gravitoelectric (GE) and Lense-Thirring (LT) fields. We apply our results to the so-far still hypothetical scenario involving a pulsar orbiting the supermassive black hole in the galactic center at Sgr A*. We also evaluate the gravitomagnetic and quadrupolar Shapiro-like propagation delays δτ{sub prop}. By assuming the orbit of the existing main sequence star S2 and a time span as long as its orbital period P{sub b}, we obtain vertical stroke Δδτ{sub p}{sup GE} vertical stroke shifts per revolution as large as vertical stroke left angle Δδτ{sub p}{sup GE} right angle vertical stroke

  18. A Perturbation Analysis of Harmonics Generation from Saturated Elements in Power Systems

    Kumano, Teruhisa

    Nonlinear phenomena such as saturation in magnetic flux give considerable effects in power system analysis. It is reported that a failure in a real 500kV system triggered islanding operation, where resultant even harmonics caused malfunctions in protective relays. It is also reported that the major origin of this wave distortion is nothing but unidirectional magnetization of the transformer iron core. Time simulation is widely used today to analyze this type of phenomena, but it has basically two shortcomings. One is that the time simulation takes two much computing time in the vicinity of inflection points in the saturation characteristic curve because certain iterative procedure such as N-R (Newton-Raphson) should be used and such methods tend to be caught in an ill conditioned numerical hunting. The other is that such simulation methods sometimes do not help intuitive understanding of the studied phenomenon because the whole nonlinear equations are treated in a matrix form and not properly divided into understandable parts as done in linear systems. This paper proposes a new computation scheme which is based on so called perturbation method. Magnetic saturation in iron cores in a generator and a transformer are taken into account. The proposed method has a special feature against the first shortcoming of the N-R based time simulation method stated above. In the proposed method no iterative process is used to reduce the equation residue but uses perturbation series, which means free from the ill condition problem. Users have only to calculate each perturbation terms one by one until he reaches necessary accuracy. In a numerical example treated in the present paper the first order perturbation can make reasonably high accuracy, which means very fast computing. In numerical study three nonlinear elements are considered. Calculated results are almost identical to the conventional Newton-Raphson based time simulation, which shows the validity of the method. The

  19. Uncertainty Analysis of Few Group Cross Sections Based on Generalized Perturbation Theory

    Han, Tae Young; Lee, Hyun Chul; Noh, Jae Man

    2014-01-01

    In this paper, the methodology of the sensitivity and uncertainty analysis code based on GPT was described and the preliminary verification calculations on the PMR200 pin cell problem were carried out. As a result, they are in a good agreement when compared with the results by TSUNAMI. From this study, it is expected that MUSAD code based on GPT can produce the uncertainty of the homogenized few group microscopic cross sections for a core simulator. For sensitivity and uncertainty analyses for general core responses, a two-step method is available and it utilizes the generalized perturbation theory (GPT) for homogenized few group cross sections in the first step and stochastic sampling method for general core responses in the second step. The uncertainty analysis procedure based on GPT in the first step needs the generalized adjoint solution from a cell or lattice code. For this, the generalized adjoint solver has been integrated into DeCART in our previous work. In this paper, MUSAD (Modues of Uncertainty and Sensitivity Analysis for DeCART) code based on the classical perturbation theory was expanded to the function of the sensitivity and uncertainty analysis for few group cross sections based on GPT. First, the uncertainty analysis method based on GPT was described and, in the next section, the preliminary results of the verification calculation on a VHTR pin cell problem were compared with the results by TSUNAMI of SCALE 6.1

  20. Supersymmetry restoration in superstring perturbation theory

    Sen, Ashoke

    2015-01-01

    Superstring perturbation theory based on the 1PI effective theory approach has been useful for addressing the problem of mass renormalization and vacuum shift. We derive Ward identities associated with space-time supersymmetry transformation in this approach. This leads to a proof of the equality of renormalized masses of bosons and fermions and identities relating fermionic amplitudes to bosonic amplitudes after taking into account the effect of mass renormalization. This also relates unbroken supersymmetry to a given order in perturbation theory to absence of tadpoles of massless scalars to higher order. The results are valid at the perturbative vacuum as well as in the shifted vacuum when the latter describes the correct ground state of the theory. We apply this to SO(32) heterotic string theory on Calabi-Yau 3-folds where a one loop Fayet-Iliopoulos term apparently breaks supersymmetry at one loop, but analysis of the low energy effective field theory indicates that there is a nearby vacuum where supersymmetry is restored. We explicitly prove that the perturbative amplitudes of this theory around the shifted vacuum indeed satisfy the Ward identities associated with unbroken supersymmetry. We also test the general arguments by explicitly verifying the equality of bosonic and fermionic masses at one loop order in the shifted vacuum, and the appearance of two loop dilaton tadpole in the perturbative vacuum where supersymmetry is expected to be broken.

  1. Supersymmetry restoration in superstring perturbation theory

    Sen, Ashoke [Harish-Chandra Research Institute,Chhatnag Road, Jhusi, Allahabad 211019 (India)

    2015-12-14

    Superstring perturbation theory based on the 1PI effective theory approach has been useful for addressing the problem of mass renormalization and vacuum shift. We derive Ward identities associated with space-time supersymmetry transformation in this approach. This leads to a proof of the equality of renormalized masses of bosons and fermions and identities relating fermionic amplitudes to bosonic amplitudes after taking into account the effect of mass renormalization. This also relates unbroken supersymmetry to a given order in perturbation theory to absence of tadpoles of massless scalars to higher order. The results are valid at the perturbative vacuum as well as in the shifted vacuum when the latter describes the correct ground state of the theory. We apply this to SO(32) heterotic string theory on Calabi-Yau 3-folds where a one loop Fayet-Iliopoulos term apparently breaks supersymmetry at one loop, but analysis of the low energy effective field theory indicates that there is a nearby vacuum where supersymmetry is restored. We explicitly prove that the perturbative amplitudes of this theory around the shifted vacuum indeed satisfy the Ward identities associated with unbroken supersymmetry. We also test the general arguments by explicitly verifying the equality of bosonic and fermionic masses at one loop order in the shifted vacuum, and the appearance of two loop dilaton tadpole in the perturbative vacuum where supersymmetry is expected to be broken.

  2. Scenario aggregation and analysis via Mean-Shift Methodology

    Mandelli, D.; Yilmaz, A.; Metzroth, K.; Aldemir, T.; Denning, R.

    2010-01-01

    A new generation of dynamic methodologies is being developed for nuclear reactor probabilistic risk assessment (PRA) which explicitly account for the time element in modeling the probabilistic system evolution and use numerical simulation tools to account for possible dependencies between failure events. The dynamic event tree (DET) approach is one of these methodologies. One challenge with dynamic PRA methodologies is the large amount of data they produce which may be difficult to analyze without appropriate software tools. The concept of 'data mining' is well known in the computer science community and several methodologies have been developed in order to extract useful information from a dataset with a large number of records. Using the dataset generated by the DET analysis of the reactor vessel auxiliary cooling system (RVACS) of an ABR-1000 for an aircraft crash recovery scenario and the Mean-Shift Methodology for data mining, it is shown how clusters of transients with common characteristics can be identified and classified. (authors)

  3. Development of a sensitivity analysis systems in nuclear reactors through generalized perturbation theory at first order in 2 D geometries

    Garcia, Juan Matias

    2005-01-01

    Perturbation Methods represent a powerful tool to do sensitivity analysis, and they found many aplications in nuclear engineering.As an introduction to this kind of analysis, we develope a program that apply the Generalized Perturbation Theory or GPT Method to bidimensional system of rectangular geometry.We first consider an homogeneous system of non-multiplying material and then an heterogeneous system with region of multiplying material, with the intention of make concret aplications of perturbation method to nuclear engineering problems.The program, that we called Pert, determines neutron fluxes and importance functions applying the Multigroup Diffusion Theory; and also solves the integrals required to calculate sensitivity coefficients.Using this perturbation methods we could verify the low computational cost required to make this kind of analysis and the simplicity of the equations systems involved, allowing us to make elaborates sensitivity analysis for the responses of our interest

  4. Analysis of 2D reactor core using linear perturbation theory and nodal finite element methods

    Adrian Mugica; Edmundo del Valle

    2005-01-01

    In this work the multigroup steady state neutron diffusion equations are solved using the nodal finite element method (NFEM) and the Linear Perturbation Theory (LPT) for XY geometry. The NFEM used corresponds to the Raviart-Thomas schemes RT0 and RT1, interpolating 5 and 12 parameters respectively in each node of the space discretization. The accuracy of these methods is related with the dimension of the space approximation and the mesh size. Therefore, using fine meshes and the RT0 or RT1 nodal methods leads to a large an interesting eigenvalue problem. The finite element method used to discretize the weak formulation of the diffusion equations is the Galerkin one. The algebraic structure of the discrete eigenvalue problem is obtained and solved using the Wielandt technique and the BGSTAB iterative method using the SPARSKIT package developed by Yousef Saad. The results obtained with LPT show good agreement with the results obtained directly for the perturbed problem. In fact, the cpu time to solve a single problem, the unperturbed and the perturbed one, is practically the same but when one is focused in shuffling many times two different assemblies in the core then the LPT technique becomes quite useful to get good approximations in a short time. This particular problem was solved for one quarter-core with NFEM. Thus, the computer program based on LPT can be used to perform like an analysis tool in the fuel reload optimization or combinatory analysis to get reload patterns in nuclear power plants once that it had been incorporated with the thermohydraulic aspects needed to simulate accurately a real problem. The maximum differences between the NFEM and LPT for the three LWR reactor cores are about 250 pcm. This quantity is considered an acceptable value for this kind of analysis. (authors)

  5. Homotopy perturbation method for free vibration analysis of beams on elastic foundation

    Ozturk, Baki; Coskun, Safa Bozkurt; Koc, Mehmet Zahid; Atay, Mehmet Tarik

    2010-01-01

    In this study, the homotopy perturbation method (HPM) is applied for free vibration analysis of beam on elastic foundation. This numerical method is applied on a previously available case study. Analytical solutions and frequency factors are evaluated for different ratios of axial load N acting on the beam to Euler buckling load, N r . The application of HPM for the particular problem in this study gives results which are in excellent agreement with both analytical solutions and the variational iteration method (VIM) solutions for the case considered in this study and the differential transform method (DTM) results available in the literature.

  6. Studies on thermal neutron perturbation factor needed for bulk sample activation analysis

    Csikai, J; Sanami, T; Michikawa, T

    2002-01-01

    The spatial distribution of thermal neutrons produced by an Am-Be source in a graphite pile was measured via the activation foil method. The results obtained agree well with calculated data using the MCNP-4B code. A previous method used for the determination of the average neutron flux within thin absorbing samples has been improved and extended for a graphite moderator. A procedure developed for the determination of the flux perturbation factor renders the thermal neutron activation analysis of bulky samples of unknown composition possible both in hydrogenous and graphite moderators.

  7. Disruptive event uncertainties in a perturbation approach to nuclear waste repository risk analysis

    Harvey, T.F.

    1980-09-01

    A methodology is developed for incorporating a full range of the principal forecasting uncertainties into a risk analysis of a nuclear waste repository. The result of this methodology is a set of risk curves similar to those used by Rasmussen in WASH-1400. The set of curves is partially derived from a perturbation approach to analyze potential disruptive event sequences. Such a scheme could be useful in truncating the number of disruptive event scenarios and providing guidance to those establishing data-base development priorities.

  8. A cognitive-pragmatic model for translation-shift analysis in ...

    A cognitive-pragmatic model for translation-shift analysis in descriptive case ... This model responds to the tendency of descriptive studies to analyse all translation shifts under the same rubric of neutrality. ... AJOL African Journals Online.

  9. Dynamic Characteristics Analysis of Power Shift Control Valve

    Feng Ren

    2014-07-01

    Full Text Available In order to study the influence that dynamic performance of shift control valve has on shifting process of construction machinery, the paper introduces working principle of the shift control valve and sets up the dynamically mathematical model and corresponding simulation model with simulation software LMS Imagine. Lab AMESim. Based on simulation, the paper analyzes the influence of pressure variation characteristics and buffering characteristics acting on vehicle performance during the process of shifting, meanwhile conducting experiments to verify the simulation. The results indicate that the simulation model is accurate and credible; the performance of the valve is satisfactory, which indeed reduces impact during shifting. Furthermore, the valve can meet the demand of other construction machineries in better degree by suitable matching between control spring stiffness and damping holes diameter.

  10. Change in Allosteric Network Affects Binding Affinities of PDZ Domains: Analysis through Perturbation Response Scanning

    Gerek, Z. Nevin; Ozkan, S. Banu

    2011-01-01

    The allosteric mechanism plays a key role in cellular functions of several PDZ domain proteins (PDZs) and is directly linked to pharmaceutical applications; however, it is a challenge to elaborate the nature and extent of these allosteric interactions. One solution to this problem is to explore the dynamics of PDZs, which may provide insights about how intramolecular communication occurs within a single domain. Here, we develop an advancement of perturbation response scanning (PRS) that couples elastic network models with linear response theory (LRT) to predict key residues in allosteric transitions of the two most studied PDZs (PSD-95 PDZ3 domain and hPTP1E PDZ2 domain). With PRS, we first identify the residues that give the highest mean square fluctuation response upon perturbing the binding sites. Strikingly, we observe that the residues with the highest mean square fluctuation response agree with experimentally determined residues involved in allosteric transitions. Second, we construct the allosteric pathways by linking the residues giving the same directional response upon perturbation of the binding sites. The predicted intramolecular communication pathways reveal that PSD-95 and hPTP1E have different pathways through the dynamic coupling of different residue pairs. Moreover, our analysis provides a molecular understanding of experimentally observed hidden allostery of PSD-95. We show that removing the distal third alpha helix from the binding site alters the allosteric pathway and decreases the binding affinity. Overall, these results indicate that (i) dynamics plays a key role in allosteric regulations of PDZs, (ii) the local changes in the residue interactions can lead to significant changes in the dynamics of allosteric regulations, and (iii) this might be the mechanism that each PDZ uses to tailor their binding specificities regulation. PMID:21998559

  11. Sensitivity theory for reactor burnup analysis based on depletion perturbation theory

    Yang, Wonsik.

    1989-01-01

    The large computational effort involved in the design and analysis of advanced reactor configurations motivated the development of Depletion Perturbation Theory (DPT) for general fuel cycle analysis. The work here focused on two important advances in the current methods. First, the adjoint equations were developed for using the efficient linear flux approximation to decouple the neutron/nuclide field equations. And second, DPT was extended to the constrained equilibrium cycle which is important for the consistent comparison and evaluation of alternative reactor designs. Practical strategies were formulated for solving the resulting adjoint equations and a computer code was developed for practical applications. In all cases analyzed, the sensitivity coefficients generated by DPT were in excellent agreement with the results of exact calculations. The work here indicates that for a given core response, the sensitivity coefficients to all input parameters can be computed by DPT with a computational effort similar to a single forward depletion calculation

  12. Analysis of Hydrogen/Air Turbulent Premixed Flames at Different Karlovitz Numbers Using Computational Singular Perturbation

    Manias, Dimitrios

    2018-01-08

    The dynamics and structure of two turbulent H2/air premixed flames, representative of the corrugated flamelet (Case 1) and thin reaction zone (Case 2) regimes, are analyzed and compared, using the computational singular perturbation (CSP) tools, by incorporating the tangential stretch rate (TSR) approach. First, the analysis is applied to a laminar premixed H2/air flame for reference. Then, a two-dimensional (2D) slice of Case 1 is studied at three time steps, followed by the comparison between two representative 2D slices of Case 1 and Case 2, respectively. Last, statistical analysis is performed on the full three-dimensional domain for the two cases. The dominant reaction and transport processes are identified for each case and the overall role of kinetics/transport is determined.

  13. Irreducible Brillouin conditions and contracted Schroedinger equations for n-electron systems. IV. Perturbative analysis

    Kutzelnigg, Werner; Mukherjee, Debashis

    2004-01-01

    in terms of a localized representation. The perturbative analysis does not encourage the use of a k-particle hierarchy based on the ICSE k (or on their reducible counterparts, the CSE k ), it rather favors the approach in terms of the unitary transformation, where the k-particle approximation yields the energy correct up to E 2k-1 . The problems that arise are related to the unavoidable appearance of exclusion-principle violating cumulants. The good experience with perturbation theory in terms of a unitary transformation suggests that one should abandon a linearly convergent iteration scheme based on the ICSE k hierarchy, in favor of a quadratically convergent one based on successive unitary transformations

  14. Perturbation and Stability Analysis of the Multi-Anticipative Intelligent Driver Model

    Chen, Xi-Qun; Xie, Wei-Jun; Shi, Jing; Shi, Qi-Xin

    This paper discusses three kinds of IDM car-following models that consider both the multi-anticipative behaviors and the reaction delays of drivers. Here, the multi-anticipation comes from two ways: (1) the driver is capable of evaluating the dynamics of several preceding vehicles, and (2) the autonomous vehicles can obtain the velocity and distance information of several preceding vehicles via inter-vehicle communications. In this paper, we study the stability of homogeneous traffic flow. The linear stability analysis indicates that the stable region will generally be enlarged by the multi-anticipative behaviors and reduced by the reaction delays. The temporal amplification and the spatial divergence of velocities for local perturbation are also studied, where the results further prove this conclusion. Simulation results also show that the multi-anticipative behaviors near the bottleneck will lead to a quicker backwards propagation of oscillations.

  15. On the Performance Analysis of Digital Communication Systems Perturbed by Non-Gaussian Noise and Interference

    Soury, Hamza

    2016-06-29

    The Gaussian distribution is typically used to model the additive noise affecting communication systems. However, in many cases the noise cannot be modeled by a Gaussian distribution. In this thesis, we investigate the performance of different communication systems perturbed by non-Gaussian noise. Three families of noise are considered in this work, namely the generalized Gaussian noise, the Laplace noise/interference, and the impulsive noise that is modeled by an α-stable distribution. More specifically, in the first part of this thesis, the impact of an additive generalized Gaussian noise is studied by computing the average symbol error rate (SER) of one dimensional and two dimensional constellations in fading environment. We begin by the simple case of two symbols, i.e. binary phase shift keying (BPSK) constellation. From the results of this constellation, we extended the work to the average SER of an M pulse amplitude modulation (PAM). The first 2 − D constellation is the M quadrature amplitude modulation (QAM) (studied for two geometric shapes, namely square and rectangular), which is the combination of two orthogonal PAM signals (in-phase and quadrature phase PAM). In the second part, the system performance of a circular constellation, namely M phase shift keying (MPSK) is studied in conjunction with a Laplace noise with independent noise components. A closed form and an asymptotic expansion of the SER are derived for two detectors, maximum likelihood and minimum distance detectors. Next, we look at the intra cell interference of a full duplex cellular network which is shown to follow a Laplacian distribution with dependent, but uncorrelated, complex components. The densities of that interference are expressed in a closed form in order to obtain the SER of several communication systems (BPSK, PAM, QAM, and MPSK). Finally, we study the statistics of the α-stable distribution. Those statistics are expressed in closed form in terms of the Fox H function and

  16. GENOVA: a generalized perturbation theory program for various applications to CANDU core physics analysis (II) - a user's manual

    Kim, Do Heon; Choi, Hang Bok

    2001-03-01

    A user's guide for GENOVA, a GENeralized perturbation theory (GPT)-based Optimization and uncertainty analysis program for Canada deuterium uranium (CANDU) physics VAriables, was prepared. The program was developed under the framework of CANDU physics design and analysis code RFSP. The generalized perturbation method was implemented in GENOVA to estimate the zone controller unit (ZCU) level upon refueling operation and calculate various sensitivity coefficients for fuel management study and uncertainty analyses, respectively. This documentation contains descriptions and directions of four major modules of GENOVA such as ADJOINT, GADJINT, PERTURB, and PERTXS so that it can be used as a practical guide for GENOVA users. This documentation includes sample inputs for the ZCU level estimation and sensitivity coefficient calculation, which are the main application of GENOVA. The GENOVA can be used as a supplementary tool of the current CANDU physics design code for advanced CANDU core analysis and fuel development

  17. Systems Perturbation Analysis of a Large-Scale Signal Transduction Model Reveals Potentially Influential Candidates for Cancer Therapeutics

    Puniya, Bhanwar Lal; Allen, Laura; Hochfelder, Colleen; Majumder, Mahbubul; Helikar, Tomáš

    2016-01-01

    Dysregulation in signal transduction pathways can lead to a variety of complex disorders, including cancer. Computational approaches such as network analysis are important tools to understand system dynamics as well as to identify critical components that could be further explored as therapeutic targets. Here, we performed perturbation analysis of a large-scale signal transduction model in extracellular environments that stimulate cell death, growth, motility, and quiescence. Each of the model’s components was perturbed under both loss-of-function and gain-of-function mutations. Using 1,300 simulations under both types of perturbations across various extracellular conditions, we identified the most and least influential components based on the magnitude of their influence on the rest of the system. Based on the premise that the most influential components might serve as better drug targets, we characterized them for biological functions, housekeeping genes, essential genes, and druggable proteins. The most influential components under all environmental conditions were enriched with several biological processes. The inositol pathway was found as most influential under inactivating perturbations, whereas the kinase and small lung cancer pathways were identified as the most influential under activating perturbations. The most influential components were enriched with essential genes and druggable proteins. Moreover, known cancer drug targets were also classified in influential components based on the affected components in the network. Additionally, the systemic perturbation analysis of the model revealed a network motif of most influential components which affect each other. Furthermore, our analysis predicted novel combinations of cancer drug targets with various effects on other most influential components. We found that the combinatorial perturbation consisting of PI3K inactivation and overactivation of IP3R1 can lead to increased activity levels of apoptosis

  18. Analysis of modal shift in South Africa: A qualitative investigation

    Venter, Karien

    2013-07-01

    Full Text Available The qualitative investigation into factors facilitating modal shift formed part of a larger research study that was conducted by the CSIR for the National Department of Transport. The aim of the study was to understand the factors that are most...

  19. Three-dimensional instability analysis of boundary layers perturbed by streamwise vortices

    Martín, Juan A.; Paredes, Pedro

    2017-12-01

    A parametric study is presented for the incompressible, zero-pressure-gradient flat-plate boundary layer perturbed by streamwise vortices. The vortices are placed near the leading edge and model the vortices induced by miniature vortex generators (MVGs), which consist in a spanwise-periodic array of small winglet pairs. The introduction of MVGs has been experimentally proved to be a successful passive flow control strategy for delaying laminar-turbulent transition caused by Tollmien-Schlichting (TS) waves. The counter-rotating vortex pairs induce non-modal, transient growth that leads to a streaky boundary layer flow. The initial intensity of the vortices and their wall-normal distances to the plate wall are varied with the aim of finding the most effective location for streak generation and the effect on the instability characteristics of the perturbed flow. The study includes the solution of the three-dimensional, stationary, streaky boundary layer flows by using the boundary region equations, and the three-dimensional instability analysis of the resulting basic flows by using the plane-marching parabolized stability equations. Depending on the initial circulation and positioning of the vortices, planar TS waves are stabilized by the presence of the streaks, resulting in a reduction in the region of instability and shrink of the neutral stability curve. For a fixed maximum streak amplitude below the threshold for secondary instability (SI), the most effective wall-normal distance for the formation of the streaks is found to also offer the most stabilization of TS waves. By setting a maximum streak amplitude above the threshold for SI, sinuous shear layer modes become unstable, as well as another instability mode that is amplified in a narrow region near the vortex inlet position.

  20. Hyperfine structure and isotope shift analysis of singly ionized titanium

    Bouazza, Safa

    2013-04-01

    The even-parity low configuration system of Ti II has been considered on the basis of the experimental data found in the literature, and its fine structure has been reanalyzed by simultaneous parameterization of one- and two-body interactions for the model space (3d + 4s)3. Furthermore, the main one-electron hyperfine structure parameters for these configurations have been evaluated. For instance, for 3d24s1, a_{3{\\rm{d}}}^{01} = - {\\rm{63}}.{\\rm{2}}\\left( {{\\rm{3}}.{\\rm{1}}} \\right)\\,{\\rm{MHz}} and a_{4{\\rm{s}}}^{10} = - {\\rm{984}}.{\\rm{1}}\\left( {{\\rm{7}}.{\\rm{1}}} \\right)\\,{\\rm{MHz}} . Field shifts (FS) and specific mass shifts (SMS) of the main Ti II configurations are deduced by means of ab initio estimates combined with a small quantity of experimental isotope shift data available in the literature: FS(3d3) = -63.3 MHz, FS(3d24p1) = -49.7 MHz, FS(3d14s2) = 98.2 MHz, FS(4s24P1) = 163.4 MHz and SMS(3d3) = 1453.3 MHz, SMS(3d14s2) = -2179.7 MHz, …, referred to 3d24s1 for the pair Ti46-Ti48.

  1. Does perturbation-based balance training prevent falls? Systematic review and meta-analysis of preliminary randomized controlled trials.

    Mansfield, Avril; Wong, Jennifer S; Bryce, Jessica; Knorr, Svetlana; Patterson, Kara K

    2015-05-01

    Older adults and individuals with neurological conditions are at an increased risk for falls. Although physical exercise can prevent falls, certain types of exercise may be more effective. Perturbation-based balance training is a novel intervention involving repeated postural perturbations aiming to improve control of rapid balance reactions. The purpose of this study was to estimate the effect of perturbation-based balance training on falls in daily life. MEDLINE (1946-July 2014), EMBASE (1974-July 2014), PEDro (all dates), CENTRAL (1991-July 2014), and Google Scholar (all dates) were the data sources used in this study. Randomized controlled trials written in English were included if they focused on perturbation-based balance training among older adults or individuals with neurological conditions and collected falls data posttraining. Two investigators extracted data independently. Study authors were contacted to obtain missing information. A PEDro score was obtained for each study. Primary outcomes were proportion of participants who reported one or more falls (ie, number of "fallers") and the total number of falls. The risk ratio (proportion of fallers) and rate ratio (number of falls) were entered into the analysis. Eight studies involving 404 participants were included. Participants who completed perturbation-based balance training were less likely to report a fall (overall risk ratio=0.71; 95% confidence interval=0.52, 0.96; P=.02) and reported fewer falls than those in the control groups (overall rate ratio=0.54; 95% confidence interval=0.34, 0.85; P=.007). Study authors do not always identify that they have included perturbation training in their intervention; therefore, it is possible that some appropriate studies were not included. Study designs were heterogeneous, preventing subanalyses. Perturbation-based balance training appears to reduce fall risk among older adults and individuals with Parkinson disease. © 2015 American Physical Therapy Association.

  2. Computational singular perturbation analysis of super-knock in SI engines

    Jaasim, Mohammed

    2018-04-02

    Pre-ignition engine cycles leading to super-knock were simulated with a 48 species skeletal iso-octane mechanism to identify the dominant reaction pathways that are present in super-knock. To mimic pre-ignition, a deflagration front was generated via a hot spot that is placed over the piston at close proximity to the end-wall. Computational singular perturbation (CSP) was used to analyze the chemical dynamics at various in-cylinder locations: a point at the center of the cylinder where the deflagration front consumes the air/fuel mixture and two points located at 3 mm from the end-wall where super-knock and mild knock occur. The CSP analysis of the point at the center of the cylinder reveals weak two-stage ignition-like dynamics with a short second stage. At the other points, a pronounced two-stage ignition is displayed with a long second stage. A distinct contribution of formaldehyde (CHO) at the second stage of ignition that adds to fast explosive modes in the super-knock points is not observed in the point at the center. A comparison between knock and super-knock analysis indicates that a similar set of reactions is responsible for the abnormal behavior but the fast explosive time scales are comparatively slower for knock, indicating lower reactivity, which results in the reduced intensity of knock. The analyzed results decoded important reactions responsible for the occurrence of super-knock.

  3. Quasidynamic emergency analysis, identification and control of power system frequency perturbations

    Jovanovic, S M [Nikola Tesla Institute, Belgrade (YU)

    1990-07-01

    There are several possible operating states of a power system. These are the normal operating state (both secure and insecure), the emergency state, the extreme emergency state and the restorative state. The system enters the emergency operating state if any of the operating constraints are violated. Emergency analysis attempts to compute in real time the violations of these constraints and the new (successive) disturbances which arise from the initial ones. The paper presents a quasidynamic approach to emergency state analysis, identification and control of power system frequency perturbations. A quasidynamic model is derived by simplifying the conventional long-term dynamics model of power systems in the time interval 0-5 s. The quasidynamic model is algebraic in nature, but the time variable t is incorporated into the model and is used to describe the part of the system dynamics that is of interest in the specified time interval. The paper proposes an on-line computer emergency control strategy based on the above quasidynamic model. Finally, a numerical example is given for the Yugoslav power system. (author).

  4. Perturbations in amino acids and metabolic pathways in osteoarthritis patients determined by targeted metabolomics analysis.

    Chen, Rui; Han, Su; Liu, Xuefeng; Wang, Kunpeng; Zhou, Yong; Yang, Chundong; Zhang, Xi

    2018-05-15

    Osteoarthritis (OA) is a degenerative synovial joint disease affecting people worldwide. However, the exact pathogenesis of OA remains unclear. Metabolomics analysis was performed to obtain insight into possible pathogenic mechanisms and diagnostic biomarkers of OA. Ultra-high performance liquid chromatography-triple quadrupole mass spectrometry (UPLC-TQ-MS), followed by multivariate statistical analysis, was used to determine the serum amino acid profiles of 32 OA patients and 35 healthy controls. Variable importance for project values and Student's t-test were used to determine the metabolic abnormalities in OA. Another 30 OA patients were used as independent samples to validate the alterations in amino acids. MetaboAnalyst was used to identify the key amino acid pathways and construct metabolic networks describing their relationships. A total of 25 amino acids and four biogenic amines were detected by UPLC-TQ-MS. Differences in amino acid profiles were found between the healthy controls and OA patients. Alanine, γ-aminobutyric acid and 4-hydroxy-l-proline were important biomarkers distinguishing OA patients from healthy controls. The metabolic pathways with the most significant effects were involved in metabolism of alanine, aspartate, glutamate, arginine and proline. The results of this study improve understanding of the amino acid metabolic abnormalities and pathogenic mechanisms of OA at the molecular level. The metabolic perturbations may be important for the diagnosis and prevention of OA. Copyright © 2018 Elsevier B.V. All rights reserved.

  5. Linear analysis on the growth of non-spherical perturbations in supersonic accretion flows

    Takahashi, Kazuya; Yamada, Shoichi, E-mail: ktakahashi@heap.phys.waseda.ac.jp [Advanced Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku 169-8555 (Japan)

    2014-10-20

    We analyzed the growth of non-spherical perturbations in supersonic accretion flows. We have in mind an application to the post-bounce phase of core-collapse supernovae (CCSNe). Such non-spherical perturbations have been suggested by a series of papers by Arnett, who has numerically investigated violent convections in the outer layers of pre-collapse stars. Moreover, Couch and Ott demonstrated in their numerical simulations that such perturbations may lead to a successful supernova even for a progenitor that fails to explode without fluctuations. This study investigated the linear growth of perturbations during the infall onto a stalled shock wave. The linearized equations are solved as an initial and boundary value problem with the use of a Laplace transform. The background is a Bondi accretion flow whose parameters are chosen to mimic the 15 M {sub ☉} progenitor model by Woosley and Heger, which is supposed to be a typical progenitor of CCSNe. We found that the perturbations that are given at a large radius grow as they flow down to the shock radius; the density perturbations can be amplified by a factor of 30, for example. We analytically show that the growth rate is proportional to l, the index of the spherical harmonics. We also found that the perturbations oscillate in time with frequencies that are similar to those of the standing accretion shock instability. This may have an implication for shock revival in CCSNe, which will be investigated in our forthcoming paper in more detail.

  6. Simultaneous analysis in renormalization and factorization scheme dependences in perturbative QCD

    Nakkagawa, Hisao; Niegawa, Akira.

    1983-01-01

    Combined and thorough investigations of both the factorization and the renormalization scheme dependences of perturbative QCD calculations are given. Our findings are that (i) by introducing a multiscale-dependent coupling the simultaneous parametrization of both scheme-dependences can be accomplished, (ii) Stevenson's optimization method works quite well so that it gives a remarkable prediction which forces us to exponentiate ''everything'' with uncorrected subprocess cross sections, and (iii) the perturbation series in QCD may converge when Stevenson's principle of minimal sensitivity is taken into account at each order of perturbative approximation. (author)

  7. Analysis of Hydrogen/Air Turbulent Premixed Flames at Different Karlovitz Numbers Using Computational Singular Perturbation

    Manias, Dimitrios; Tingas, Alexandros-Efstathios; Hernandez Perez, Francisco E.; Im, Hong G.; Galassi, Riccardo Malpica; Ciottoli, Pietro Paolo; Valorani, Mauro

    2018-01-01

    The dynamics and structure of two turbulent H2/air premixed flames, representative of the corrugated flamelet (Case 1) and thin reaction zone (Case 2) regimes, are analyzed and compared, using the computational singular perturbation (CSP) tools

  8. A perturbative analysis of modulated amplitude waves in Bose-Einstein condensates

    Porter, Mason A.; Cvitanovic, Predrag

    2004-01-01

    We apply Lindstedt's method and multiple scale perturbation theory to analyze spatio-temporal structures in nonlinear Schroedinger equations and thereby study the dynamics of quasi-one-dimensional Bose-Einstein condensates with mean-field interactions. We determine the dependence of the amplitude of modulated amplitude waves on their wave number. We also explore the band structure of Bose-Einstein condensates in detail using Hamiltonian perturbation theory and supporting numerical simulations

  9. An analytic analysis of the pion decay constant in three-flavoured chiral perturbation theory

    Ananthanarayan, B.; Ghosh, Shayan [Indian Institute of Science, Centre for High Energy Physics, Bangalore, Karnataka (India); Bijnens, Johan [Lund University, Department of Astronomy and Theoretical Physics, Lund (Sweden)

    2017-07-15

    A representation of the two-loop contribution to the pion decay constant in SU(3) chiral perturbation theory is presented. The result is analytic up to the contribution of the three (different) mass sunset integrals, for which an expansion in their external momentum has been taken. We also give an analytic expression for the two-loop contribution to the pion mass based on a renormalized representation and in terms of the physical eta mass. We find an expansion of F{sub π} and M{sub π}{sup 2} in the strange-quark mass in the isospin limit, and we perform the matching of the chiral SU(2) and SU(3) low-energy constants. A numerical analysis demonstrates the high accuracy of our representation, and the strong dependence of the pion decay constant upon the values of the low-energy constants, especially in the chiral limit. Finally, we present a simplified representation that is particularly suitable for fitting with available lattice data. (orig.)

  10. Strategic Deconfliction of 4D Trajectory and Perturbation Analysis for Air Traffic Control and Automation System

    Xinmin Tang

    2016-01-01

    Full Text Available Strategic 4D trajectory conflict-free planning is recognized as one of the core technologies of next-generation air traffic control and automation systems. To resolve potential conflicts during strategic 4D conflict-free trajectory planning, a protection-zone conflict-control model based on air traffic control separation constraints was proposed, in which relationships between expected arrival time and adjusted arrival time at conflicting waypoints for aircraft queues were built and transformed into dynamic linear equations under the definition of max-plus algebra. A method for strategic deconfliction of 4D trajectory was then proposed using two strategies: arrival time adjustment and departure time adjustment. In addition, departure time and flight duration perturbations were introduced to analyze the sensitivity of the planned strategic conflict-free 4D trajectories, and a robustness index for the conflict-free 4D trajectories was calculated. Finally, the proposed method was tested for the Shanghai air traffic control terminal area. The outcomes demonstrated that the planned strategic conflict-free 4D trajectories could avoid potential conflicts, and the slack time could be used to indicate their robustness. Complexity analysis demonstrated that deconfliction using max-plus algebra is more suitable for deconfliction of 4D trajectory with random sampling period in fix air route.

  11. Perturbation-expression analysis identifies RUNX1 as a regulator of human mammary stem cell differentiation.

    Ethan S Sokol

    2015-04-01

    Full Text Available The search for genes that regulate stem cell self-renewal and differentiation has been hindered by a paucity of markers that uniquely label stem cells and early progenitors. To circumvent this difficulty we have developed a method that identifies cell-state regulators without requiring any markers of differentiation, termed Perturbation-Expression Analysis of Cell States (PEACS. We have applied this marker-free approach to screen for transcription factors that regulate mammary stem cell differentiation in a 3D model of tissue morphogenesis and identified RUNX1 as a stem cell regulator. Inhibition of RUNX1 expanded bipotent stem cells and blocked their differentiation into ductal and lobular tissue rudiments. Reactivation of RUNX1 allowed exit from the bipotent state and subsequent differentiation and mammary morphogenesis. Collectively, our findings show that RUNX1 is required for mammary stem cells to exit a bipotent state, and provide a new method for discovering cell-state regulators when markers are not available.

  12. Perturbation theory

    Bartlett, R.; Kirtman, B.; Davidson, E.R.

    1978-01-01

    After noting some advantages of using perturbation theory some of the various types are related on a chart and described, including many-body nonlinear summations, quartic force-field fit for geometry, fourth-order correlation approximations, and a survey of some recent work. Alternative initial approximations in perturbation theory are also discussed. 25 references

  13. Application of generalized perturbation theory to sensitivity analysis in boron neutron capture therapy

    Garcia, Vanessa S. [Universidade Federal Fluminense (EEIMVR/UFF-RJ), Volta Redonda, RJ (Brazil). Escola de Engenharia Industrial e Metalurgica. Programa de Pos-Graduacao em Modelagem Computacional em Ciencia e Tecnologia; Silva, Fernando C.; Silva, Ademir X., E-mail: fernando@con.ufrj.b, E-mail: ademir@con.ufrj.b [Coordenacao dos Programas de Pos-Graduacao de Engenharia (PEN/COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear; Alvarez, Gustavo B. [Universidade Federal Fluminense (EEIMVR/UFF-RJ), Volta Redonda, RJ (Brazil). Escola de Engenharia Industrial e Metalurgica. Dept. de Ciencias Exatas

    2011-07-01

    Boron neutron capture therapy - BNCT - is a binary cancer treatment used in brain tumors. The tumor is loaded with a boron compound and subsequently irradiated by thermal neutrons. The therapy is based on the {sup 10}B (n, {alpha}) {sup 7}Li nuclear reaction, which emits two types of high-energy particles, {alpha} particle and the {sup 7}Li nuclei. The total kinetic energy released in this nuclear reaction, when deposited in the tumor region, destroys the cancer cells. Since the success of the BNCT is linked to the different selectivity between the tumor and healthy tissue, it is necessary to carry out a sensitivity analysis to determinate the boron concentration. Computational simulations are very important in this context because they help in the treatment planning by calculating the lowest effective absorbed dose rate to reduce the damage to healthy tissue. The objective of this paper is to present a deterministic method based on generalized perturbation theory (GPT) to perform sensitivity analysis with respect to the {sup 10}B concentration and to estimate the absorbed dose rate by patients undergoing this therapy. The advantage of the method is a significant reduction in computational time required to perform these calculations. To simulate the neutron flux in all brain regions, the method relies on a two-dimensional neutron transport equation whose spatial, angular and energy variables are discretized by the diamond difference method, the discrete ordinate method and multigroup formulation, respectively. The results obtained through GPT are consistent with those obtained using other methods, demonstrating the efficacy of the proposed method. (author)

  14. Nonlinear vibration analysis of a rotor supported by magnetic bearings using homotopy perturbation method

    Aboozar Heydari

    2017-09-01

    Full Text Available In this paper, the effects of nonlinear forces due to the electromagnetic field of bearing and the unbalancing force on nonlinear vibration behavior of a rotor is investigated. The rotor is modeled as a rigid body that is supported by two magnetic bearings with eight-polar structures. The governing dynamics equations of the system that are coupled nonlinear second order ordinary differential equations (ODEs are derived, and for solving these equations, the homotopy perturbation method (HPM is used. By applying HPM, the possibility of presenting a harmonic semi-analytical solution, is provided. In fact, with equality the coefficient of auxiliary parameter (p, the system of coupled nonlinear second order and non-homogenous differential equations are obtained so that consists of unbalancing effects. By considering some initial condition for displacement and velocity in the horizontal and vertical directions, free vibration analysis is done and next, the forced vibration analysis under the effect of harmonic forces also is investigated. Likewise, various parameters on the vibration behavior of rotor are studied. Changes in amplitude and response phase per excitation frequency are investigated. Results show that by increasing excitation frequency, the motion amplitude is also increases and by passing the critical speed, it decreases. Also it shows that the magnetic bearing system performance is in stable maintenance of rotor. The parameters affecting on vibration behavior, has been studied and by comparison the results with the other references, which have a good precision up to 2nd order of embedding parameter, it implies the accuracy of this method in current research.

  15. Application of generalized perturbation theory to sensitivity analysis in boron neutron capture therapy

    Garcia, Vanessa S.; Silva, Fernando C.; Silva, Ademir X.; Alvarez, Gustavo B.

    2011-01-01

    Boron neutron capture therapy - BNCT - is a binary cancer treatment used in brain tumors. The tumor is loaded with a boron compound and subsequently irradiated by thermal neutrons. The therapy is based on the 10 B (n, α) 7 Li nuclear reaction, which emits two types of high-energy particles, α particle and the 7 Li nuclei. The total kinetic energy released in this nuclear reaction, when deposited in the tumor region, destroys the cancer cells. Since the success of the BNCT is linked to the different selectivity between the tumor and healthy tissue, it is necessary to carry out a sensitivity analysis to determinate the boron concentration. Computational simulations are very important in this context because they help in the treatment planning by calculating the lowest effective absorbed dose rate to reduce the damage to healthy tissue. The objective of this paper is to present a deterministic method based on generalized perturbation theory (GPT) to perform sensitivity analysis with respect to the 10 B concentration and to estimate the absorbed dose rate by patients undergoing this therapy. The advantage of the method is a significant reduction in computational time required to perform these calculations. To simulate the neutron flux in all brain regions, the method relies on a two-dimensional neutron transport equation whose spatial, angular and energy variables are discretized by the diamond difference method, the discrete ordinate method and multigroup formulation, respectively. The results obtained through GPT are consistent with those obtained using other methods, demonstrating the efficacy of the proposed method. (author)

  16. Why do lifespan variability trends for the young and old diverge? A perturbation analysis

    Michal Engelman

    2014-05-01

    Full Text Available Background: Variation in lifespan has followed strikingly different trends for the young and old: while overall lifespan variability has decreased as life expectancy at birth has risen, the variability conditional on survival to older ages has increased. These diverging trends reflect changes in the underlying demographic parameters determining age-specific mortality. Objective: We ask why the variation in the adult ages at death has followed a different trend than the variation at younger ages, and aim to explain the diverging patterns in terms of historical changes in the age schedule of mortality. Methods: Using simulations, we show that the empirical trends in lifespan variation are well characterized using the Siler model, which describes the mortality hazard across the full lifespan using functions representing early-life, later-life, and background mortality. We then obtain maximum likelihood estimates of the Siler parameters over time. Finally, we express lifespan variation in terms of a Markov chain model, and apply matrix calculus perturbation analysis to compute the sensitivity of age-specific lifespan variance trends to the changing Siler model parameters. Results: Our analysis produces a detailed quantification of the impact of changing demographic parameters on the pattern of lifespan variability at all ages, highlighting the impact of declining childhood mortality on the reduction of lifespan variability and the impact of improved survival in adulthood on the rising variability of lifespans at older ages. Conclusions: These findings provide insight into the dynamic relationship between the age pattern of survival improvements and time trends in lifespan variability.

  17. Meta-analysis on shift work and risks of specific obesity types.

    Sun, M; Feng, W; Wang, F; Li, P; Li, Z; Li, M; Tse, G; Vlaanderen, J; Vermeulen, R; Tse, L A

    2018-01-01

    This systematic review and meta-analysis evaluated the associations between shift work patterns and risks of specific types of obesity. PubMed was searched until March 2017 for observational studies that examined the relationships between shift work patterns and obesity. Odds ratio for obesity was extracted using a fixed-effects or random-effects model. Subgroup meta-analyses were carried out for study design, specific obesity types and characteristics of shift work pattern. A total of 28 studies were included in this meta-analysis. The overall odds ratio of night shift work was 1.23 (95% confidence interval = 1.17-1.29) for risk of obesity/overweight. Cross-sectional studies showed a higher risk of 1.26 than those with the cohort design (risk ratio = 1.10). Shift workers had a higher frequency of developing abdominal obesity (odds ratio = 1.35) than other obesity types. Permanent night workers demonstrated a 29% higher risk than rotating shift workers (odds ratio 1.43 vs. 1.14). This meta-analysis confirmed the risks of night shift work for the development of overweight and obesity with a potential gradient association suggested, especially for abdominal obesity. Modification of working schedules is recommended, particularly for prolonged permanent night work. More accurate and detailed measurements on shift work patterns should be conducted in future research. © 2017 World Obesity Federation.

  18. Nonlinear dynamics analysis of the human balance control subjected to physical and sensory perturbations.

    Ashtiani, Mohammed N; Mahmood-Reza, Azghani

    2017-01-01

    Postural control after applying perturbation involves neural and muscular efforts to limit the center of mass (CoM) motion. Linear dynamical approaches may not unveil all complexities of body efforts. This study was aimed at determining two nonlinear dynamics parameters (fractal dimension (FD) and largest Lyapunov exponent (LLE)) in addition to the linear standing metrics of balance in perturbed stance. Sixteen healthy young males were subjected to sudden rotations of the standing platform. The vision and cognition during the standing were also interfered. Motion capturing was used to measure the lower limb joints and the CoM displacements. The CoM path length as a linear parameter was increased by elimination of vision (pnonlinear metric FD was decreased due to the cognitive loads (pnonlinear metrics of the perturbed stance showed that a combination of them may properly represent the body behavior.

  19. A Decision Making Analysis of Persuasive Argumentation and the Choice Shift Effect

    Vinokur, Amiram; And Others

    1975-01-01

    A subjective expected utility (SEU) decision-making analysis was performed on the content of arguments generated by subjects privately or during group discussion in response to choice-dilemmas shown to shift toward risk and caution. (Editor)

  20. Analysis of Diffusion Problems using Homotopy Perturbation and Variational Iteration Methods

    Barari, Amin; Poor, A. Tahmasebi; Jorjani, A.

    2010-01-01

    In this paper, variational iteration method and homotopy perturbation method are applied to different forms of diffusion equation. The diffusion equations have found wide applications in heat transfer problems, theory of consolidation and many other problems in engineering. The methods proposed...

  1. Confined quantum electrodynamics in 1+1 dimensions : a perturbative analysis

    Aerts, A.T.M.; Hansson, T.H.

    1985-01-01

    The spectrum of confined QED in 1+1 dimensions is analysed using perturbation theory. The mass spectra of systems made up of massless fermions are calculated toO(e 2) and compared to the mass spectra obtained using nonperturbative methods. Systems containing heavy fermions are also studied and an

  2. Fuel requirements for experimental devices in MTR reactors. A perturbation model for reactor core analysis

    Beeckmans de West-Meerbeeck, A.

    1991-01-01

    Irradiation in neutron absorbing devices, requiring high fast neutron fluxes in the core or high thermal fluxes in the reflector and flux traps, lead to higher density fuel and larger core dimensions. A perturbation model of the reactor core helps to estimate the fuel requirements. (orig.)

  3. Application of the homotopy perturbation method and the homotopy analysis method for the dynamics of tobacco use and relapse

    Anant Kant Shukla

    2014-11-01

    Full Text Available We obtain approximate analytical solutions of two mathematical models of the dynamics of tobacco use and relapse including peer pressure using the homotopy perturbation method (HPM and the homotopy analysis method (HAM. To enlarge the domain of convergence we apply the Padé approximation to the HPM and HAM series solutions. We show graphically that the results obtained by both methods are very accurate in comparison with the numerical solution for a period of 30 years.

  4. Analysis of perturbations of moments associated with orthogonality linear functionals through the Szegö transformation

    Edinson Fuentes

    2015-06-01

    Full Text Available In this paper, we consider perturbations to a sequence of moments associated with an orthogonality linear functional that is represented by a positive measure supported in [−1, 1]. In particular, given a perturbation to such a measure on the real line, we analyze the perturbation obtained on the corresponding measure on the unit circle, when both measures are related through the Szeg´´o transformation. A similar perturbation is analyzed through the inverse Szeg´´o transformation. In both cases, we show that the applied perturbation can be expressed in terms of the singular part of the measures, and also in terms of the corresponding sequences of moments. Resumen. En el presente trabajo, analizamos las perturbaciones a una sucesión de momentos asociada a un funcional lineal de ortogonalidad que se representa por una medida positiva con soporte en [−1, 1]. En particular, dada una cierta perturbación a dicha medida en la recta real, analizamos la perturbación obtenida en la correspondiente medida en la circunferencia unidad, cuando dichas medidas están relacionadas por la transformación de Szeg´´o. También se analiza una perturbación similar a través de la transformación inversa de Szeg´´o. En ambos casos, se muestra que la perturbación aplicada puede ser expresada en términos de la parte singular de las medidas, y también a través de las correspondientes sucesiones de momentos.

  5. Analysis of orbit determination from Earth-based tracking for relay satellites in a perturbed areostationary orbit

    Romero, P.; Pablos, B.; Barderas, G.

    2017-07-01

    Areostationary satellites are considered a high interest group of satellites to satisfy the telecommunications needs of the foreseen missions to Mars. An areostationary satellite, in an areoequatorial circular orbit with a period of 1 Martian sidereal day, would orbit Mars remaining at a fixed location over the Martian surface, analogous to a geostationary satellite around the Earth. This work addresses an analysis of the perturbed orbital motion of an areostationary satellite as well as a preliminary analysis of the aerostationary orbit estimation accuracy based on Earth tracking observations. First, the models for the perturbations due to the Mars gravitational field, the gravitational attraction of the Sun and the Martian moons, Phobos and Deimos, and solar radiation pressure are described. Then, the observability from Earth including possible occultations by Mars of an areostationary satellite in a perturbed areosynchronous motion is analyzed. The results show that continuous Earth-based tracking is achievable using observations from the three NASA Deep Space Network Complexes in Madrid, Goldstone and Canberra in an occultation-free scenario. Finally, an analysis of the orbit determination accuracy is addressed considering several scenarios including discontinuous tracking schedules for different epochs and different areoestationary satellites. Simulations also allow to quantify the aerostationary orbit estimation accuracy for various tracking series durations and observed orbit arc-lengths.

  6. Retrospective qualitative analysis of ecological networks under environmental perturbation: a copper-polluted intertidal community as a case study.

    Ramos-Jiliberto, Rodrigo; Garay-Narváez, Leslie; Medina, Matías H

    2012-01-01

    The coast of Chañaral Bay in northern Chile has been affected by copper mine wastes for decades. This sustained perturbation has disrupted the intertidal community in several ways, but the mechanisms behind the observed shifts in local biodiversity remain poorly understood. Our main goal was to identify the species (lumped into trophic groups) belonging to the Chañaral intertidal community that, being directly affected by copper pollution, contributed primarily to the generation of the observed changes in community structure. These groups of species were called initiators. We applied a qualitative modelling approach based only on the sign and direction of effects among species, and present a formula for predicting changes in equilibrium abundances considering stress on multiple variables simultaneously. We then applied this technique retrospectively to identify the most likely set of initiators. Our analyses allowed identification of a unique set of four initiators in the studied intertidal system (a group of algae, sessile invertebrates, a group of herbivores and starfish), which were hypothesized to be the primary drivers of the observed changes in community structure. In addition, a hypothesis was derived about how the perturbation affected these initiators. The hypothesis is that pollution affected negatively the population growth rate of both algae and sessile invertebrates and suppressed the interaction between herbivores and starfish. Our analytic approach, focused on identifying initiators, constitutes an advance towards understanding the mechanisms underlying human-driven ecosystem disruption and permits identifying species that may serve as a focal point for community management and restoration.

  7. Analysis and Application of High Resolution Numerical Perturbation Algorithm for Convective-Diffusion Equation

    Gao Zhi; Shen Yi-Qing

    2012-01-01

    The high resolution numerical perturbation (NP) algorithm is analyzed and tested using various convective-diffusion equations. The NP algorithm is constructed by splitting the second order central difference schemes of both convective and diffusion terms of the convective-diffusion equation into upstream and downstream parts, then the perturbation reconstruction functions of the convective coefficient are determined using the power-series of grid interval and eliminating the truncated errors of the modified differential equation. The important nature, i.e. the upwind dominance nature, which is the basis to ensuring that the NP schemes are stable and essentially oscillation free, is firstly presented and verified. Various numerical cases show that the NP schemes are efficient, robust, and more accurate than the original second order central scheme

  8. A statistical analysis of RNA folding algorithms through thermodynamic parameter perturbation.

    Layton, D M; Bundschuh, R

    2005-01-01

    Computational RNA secondary structure prediction is rather well established. However, such prediction algorithms always depend on a large number of experimentally measured parameters. Here, we study how sensitive structure prediction algorithms are to changes in these parameters. We found already that for changes corresponding to the actual experimental error to which these parameters have been determined, 30% of the structure are falsely predicted whereas the ground state structure is preserved under parameter perturbation in only 5% of all the cases. We establish that base-pairing probabilities calculated in a thermal ensemble are viable although not a perfect measure for the reliability of the prediction of individual structure elements. Here, a new measure of stability using parameter perturbation is proposed, and its limitations are discussed.

  9. Implementation of $ab$ $initio$ perturbed angular correlation observables for analysis of fluctuating quadrupole interactions

    Barbosa, Marcelo

    A review about the nuclear properties, namely the nuclear moments (magnetic dipole moment and electric quadrupole moment) and their interaction with electromagnetic fields external to the nucleus (hyperfine interactions), as well as the angular distribution of radiation produced by $\\gamma$-decay, is presented. A detailed description about the theory of Perturbed Angular Correlations was done, including the comparison between $\\gamma-\\gamma$- correlations and $e^{-}- \\gamma$ correlations. For dynamic nuclear interactions, an introduction to the theory of stochastic states in PAC was performed. We focused on ab-initio implementation of observables for analyzing fluctuating quadrupole hyperfine interactions on time dependent perturbed angular correlations experiments. The development of computacional codes solving the full problem, adapted to fit data obtained on single crystals or polycrystals for two-state transient fields with any axial symmetry and orientation was the main purpose of this work. The final pa...

  10. Development, implementation, and verification of multicycle depletion perturbation theory for reactor burnup analysis

    White, J.R.

    1980-08-01

    A generalized depletion perturbation formulation based on the quasi-static method for solving realistic multicycle reactor depletion problems is developed and implemented within the VENTURE/BURNER modular code system. The present development extends the original formulation derived by M.L. Williams to include nuclide discontinuities such as fuel shuffling and discharge. This theory is first described in detail with particular emphasis given to the similarity of the forward and adjoint quasi-static burnup equations. The specific algorithm and computational methods utilized to solve the adjoint problem within the newly developed DEPTH (Depletion Perturbation Theory) module are then briefly discussed. Finally, the main features and computational accuracy of this new method are illustrated through its application to several representative reactor depletion problems.

  11. Non perturbative analysis of an N=2 Landau-Ginsburg model

    Leaf Herrmann, W.A.

    1993-01-01

    We analyze the topological sector of an N=2 Landau-Ginsburg model using nonperturbative methods. In particular, we study the renormalization group flow between two superconformal minimal models, numerically compute the correlation functions along this trajectory, and compare the results to semi-classical calculations. We also study some aspects of arbitrary supersymmetric perturbations of the Landau-Ginsburg model. 20 refs, 4 figs

  12. Time-Frequency Analysis of Boundary-Layer Instabilites Generated by Freestream Laser Perturbations

    Chou, Amanda; Schneider, Steven P.

    2015-01-01

    A controlled disturbance is generated in the freestream of the Boeing/AFOSR Mach-6 Quiet Tunnel (BAM6QT) by focusing a high-powered Nd:YAG laser to create a laser-induced breakdown plasma. The plasma then cools, creating a freestream thermal disturbance that can be used to study receptivity. The freestream disturbance convects down-stream in the Mach-6 wind tunnel to interact with a flared cone model. The adverse pressure gradient created by the flare of the model is capable of generating second-mode instability waves that grow large and become nonlinear before experiencing natural transition in quiet flow. The freestream laser perturbation generates a wave packet in the boundary layer at the same frequency as the natural second mode, complicating time-independent analyses of the effect of the laser perturbation. The data show that the laser perturbation creates an instability wave packet that is larger than the natural waves on the sharp flared cone. The wave packet is still difficult to distinguish from the natural instabilities on the blunt flared cone.

  13. Night Shift Work and Risk of Depression: Meta-analysis of Observational Studies.

    Lee, Aeyoung; Myung, Seung Kwon; Cho, Jung Jin; Jung, Yu Jin; Yoon, Jong Lull; Kim, Mee Young

    2017-07-01

    This study aimed to assess whether night shift work is associated with the risk of depression by using a meta-analysis of observational studies. We searched PubMed and EMBASE in August, 2016 to locate eligible studies and investigated the association between night shift work and the risk of depression, reporting outcome measures with adjusted odds ratios (ORs) or relative risks (RRs) and 95% confidence intervals (CIs). In the meta-analysis of a total of 11 observational studies with 9 cross-sectional study, 1 longitudinal study, and 1 cohort study, night shift work was significantly associated with an increased risk of depression (OR/RR, 1.43; 95% CI, 1.24-1.64; I² = 78.0%). Also, subgroup meta-analyses by gender, night shift work duration, type of occupation, continent, and type of publication showed that night shift work was consistently associated with the increased risk of depression. The current meta-analysis suggests that night shift work is associated with the increased risk of depression. However, further large prospective cohort studies are needed to confirm this association. © 2017 The Korean Academy of Medical Sciences.

  14. Stereospecific assignment of the asparagine and glutamine sidechain amide protons in proteins from chemical shift analysis

    Harsch, Tobias; Schneider, Philipp; Kieninger, Bärbel; Donaubauer, Harald; Kalbitzer, Hans Robert, E-mail: hans-robert.kalbitzer@biologie.uni-regensburg.de [University of Regensburg, Institute of Biophysics and Physical Biochemistry and Centre of Magnetic Resonance in Chemistry and Biomedicine (Germany)

    2017-02-15

    Side chain amide protons of asparagine and glutamine residues in random-coil peptides are characterized by large chemical shift differences and can be stereospecifically assigned on the basis of their chemical shift values only. The bimodal chemical shift distributions stored in the biological magnetic resonance data bank (BMRB) do not allow such an assignment. However, an analysis of the BMRB shows, that a substantial part of all stored stereospecific assignments is not correct. We show here that in most cases stereospecific assignment can also be done for folded proteins using an unbiased artificial chemical shift data base (UACSB). For a separation of the chemical shifts of the two amide resonance lines with differences ≥0.40 ppm for asparagine and differences ≥0.42 ppm for glutamine, the downfield shifted resonance lines can be assigned to H{sup δ21} and H{sup ε21}, respectively, at a confidence level >95%. A classifier derived from UASCB can also be used to correct the BMRB data. The program tool AssignmentChecker implemented in AUREMOL calculates the Bayesian probability for a given stereospecific assignment and automatically corrects the assignments for a given list of chemical shifts.

  15. Traffic Perturbation

    C. Colloca TS/FM

    2004-01-01

    TS/FM group informs you that, for the progress of the works at the Prévessin site entrance, some perturbation of the traffic may occur during the week between the 14th and 18th of June for a short duration. Access will be assured at any time. For more information, please contact 160239. C. Colloca TS/FM

  16. [Sensitivity analysis of AnnAGNPS model's hydrology and water quality parameters based on the perturbation analysis method].

    Xi, Qing; Li, Zhao-Fu; Luo, Chuan

    2014-05-01

    Sensitivity analysis of hydrology and water quality parameters has a great significance for integrated model's construction and application. Based on AnnAGNPS model's mechanism, terrain, hydrology and meteorology, field management, soil and other four major categories of 31 parameters were selected for the sensitivity analysis in Zhongtian river watershed which is a typical small watershed of hilly region in the Taihu Lake, and then used the perturbation method to evaluate the sensitivity of the parameters to the model's simulation results. The results showed that: in the 11 terrain parameters, LS was sensitive to all the model results, RMN, RS and RVC were generally sensitive and less sensitive to the output of sediment but insensitive to the remaining results. For hydrometeorological parameters, CN was more sensitive to runoff and sediment and relatively sensitive for the rest results. In field management, fertilizer and vegetation parameters, CCC, CRM and RR were less sensitive to sediment and particulate pollutants, the six fertilizer parameters (FR, FD, FID, FOD, FIP, FOP) were particularly sensitive for nitrogen and phosphorus nutrients. For soil parameters, K is quite sensitive to all the results except the runoff, the four parameters of the soil's nitrogen and phosphorus ratio (SONR, SINR, SOPR, SIPR) were less sensitive to the corresponding results. The simulation and verification results of runoff in Zhongtian watershed show a good accuracy with the deviation less than 10% during 2005- 2010. Research results have a direct reference value on AnnAGNPS model's parameter selection and calibration adjustment. The runoff simulation results of the study area also proved that the sensitivity analysis was practicable to the parameter's adjustment and showed the adaptability to the hydrology simulation in the Taihu Lake basin's hilly region and provide reference for the model's promotion in China.

  17. A canonical correlation analysis based EMG classification algorithm for eliminating electrode shift effect.

    Zhe Fan; Zhong Wang; Guanglin Li; Ruomei Wang

    2016-08-01

    Motion classification system based on surface Electromyography (sEMG) pattern recognition has achieved good results in experimental condition. But it is still a challenge for clinical implement and practical application. Many factors contribute to the difficulty of clinical use of the EMG based dexterous control. The most obvious and important is the noise in the EMG signal caused by electrode shift, muscle fatigue, motion artifact, inherent instability of signal and biological signals such as Electrocardiogram. In this paper, a novel method based on Canonical Correlation Analysis (CCA) was developed to eliminate the reduction of classification accuracy caused by electrode shift. The average classification accuracy of our method were above 95% for the healthy subjects. In the process, we validated the influence of electrode shift on motion classification accuracy and discovered the strong correlation with correlation coefficient of >0.9 between shift position data and normal position data.

  18. Variance analysis of the Monte-Carlo perturbation source method in inhomogeneous linear particle transport problems

    Noack, K.

    1982-01-01

    The perturbation source method may be a powerful Monte-Carlo means to calculate small effects in a particle field. In a preceding paper we have formulated this methos in inhomogeneous linear particle transport problems describing the particle fields by solutions of Fredholm integral equations and have derived formulae for the second moment of the difference event point estimator. In the present paper we analyse the general structure of its variance, point out the variance peculiarities, discuss the dependence on certain transport games and on generation procedures of the auxiliary particles and draw conclusions to improve this method

  19. Analysis of radionuclide transport through fissured porous media with a perturbation method

    Banat, M [JGC Corp., Tokyo (Japan)

    1995-04-01

    This paper presents a specific procedure for obtaining solutions for the transport of radionuclides in a fissured porous media. The concentration profiles are deduced for a wide range of Peclet numbers using a perturbation method with a multiscale of time. Results show clearly that because of an increase of longitudinal dispersion, the radionuclide moves faster with respect to the case of zero dispersion (i.e. an infinite Peclet number). The main purpose of this paper is to demonstrate the practical advantage of the present calculation method with respect to the classical numerical and analytical methods used for radionuclide transport. (author).

  20. Generalized perturbation theory for LWR depletion analysis and core design applications

    White, J.R.; Frank, B.R.

    1986-01-01

    A comprehensive time-dependent perturbation theory formulation that includes macroscopic depletion, thermal-hydraulic and poison feedback effects, and a criticality reset mechanism is developed. The methodology is compatible with most current LWR design codes. This new development allows GTP/DTP methods to be used quantitatively in a variety of realistic LWR physics applications that were not possible prior to this work. A GTP-based optimization technique for incore fuel management analyses is addressed as a promising application of the new formulation

  1. Black hole perturbations in vector-tensor theories: the odd-mode analysis

    Kase, Ryotaro; Minamitsuji, Masato; Tsujikawa, Shinji; Zhang, Ying-li

    2018-02-01

    In generalized Proca theories with vector-field derivative couplings, a bunch of hairy black hole solutions have been derived on a static and spherically symmetric background. In this paper, we formulate the odd-parity black hole perturbations in generalized Proca theories by expanding the corresponding action up to second order and investigate whether or not black holes with vector hair suffer ghost or Laplacian instabilities. We show that the models with cubic couplings G3(X), where X=‑AμAμ/2 with a vector field Aμ, do not provide any additional stability condition as in General Relativity. On the other hand, the exact charged stealth Schwarzschild solution with a nonvanishing longitudinal vector component A1, which originates from the coupling to the Einstein tensor GμνAμ Aν equivalent to the quartic coupling G4(X) containing a linear function of X, is unstable in the vicinity of the event horizon. The same instability problem also persists for hairy black holes arising from general quartic power-law couplings G4(X) ⊃ β4 Xn with the nonvanishing A1, while the other branch with A1=0 can be consistent with conditions for the absence of ghost and Laplacian instabilities. We also discuss the case of other exact and numerical black hole solutions associated with intrinsic vector-field derivative couplings and show that there exists a wide range of parameter spaces in which the solutions suffer neither ghost nor Laplacian instabilities against odd-parity perturbations.

  2. Analysis of the Effect of Electron Density Perturbations Generated by Gravity Waves on HF Communication Links

    Fagre, M.; Elias, A. G.; Chum, J.; Cabrera, M. A.

    2017-12-01

    In the present work, ray tracing of high frequency (HF) signals in ionospheric disturbed conditions is analyzed, particularly in the presence of electron density perturbations generated by gravity waves (GWs). The three-dimensional numerical ray tracing code by Jones and Stephenson, based on Hamilton's equations, which is commonly used to study radio propagation through the ionosphere, is used. An electron density perturbation model is implemented to this code based upon the consideration of atmospheric GWs generated at a height of 150 km in the thermosphere and propagating up into the ionosphere. The motion of the neutral gas at these altitudes induces disturbances in the background plasma which affects HF signals propagation. To obtain a realistic model of GWs in order to analyze the propagation and dispersion characteristics, a GW ray tracing method with kinematic viscosity and thermal diffusivity was applied. The IRI-2012, HWM14 and NRLMSISE-00 models were incorporated to assess electron density, wind velocities, neutral temperature and total mass density needed for the ray tracing codes. Preliminary results of gravity wave effects on ground range and reflection height are presented for low-mid latitude ionosphere.

  3. Eigenmode analysis of ballooning perturbations in the inner magnetosphere of the Earth

    A. S. Parnowski

    2007-06-01

    Full Text Available We analyze coupled Alfvén and slow magnetosonic eigenmodes in a dipole geomagnetic field with different ionospheric conductivities in the framework of ideal magnetic hydrodynamics (MHD with finite pressure. We use numerical and, if possible, analytical methods to describe eigenmode frequencies, growth rates and eigenfunctions. The spectrum of Alfvén and slow magnetosonic modes is discrete and equidistant. The frequencies of the first Alfvén and slow magnetosonic eigenmodes are estimated as ~1 Hz and ~1 mHz, respectively. In the case of finite conductivity, periodic and aperiodic modes are separated and their interaction analyzed. It was shown that periodic and aperiodic perturbations can mutually transform into each other. A new flute stability criterion is derived (α~4.25, which is stricter than the Gold criterion (α=20/3. Here, as usual, α=−L/p dp/dL. For flute perturbations, the deviations of transversal displacement from a constant are calculated. An approximation for longitudinal displacement is derived. We determined the position of the main longitudinal peak, which can be responsible for nonlinear structures observed by Freja. An influence of nonlinear terms in pressure is estimated as well.

  4. Quantum-mechanical vs. semi-classical spectral-line widths and shifts from the line core in the non-impact region for the Ar-perturbed/ K-radiator system

    Kreye, W.C.

    2007-01-01

    New quantum-mechanical (QM) and semi-classical (SC) shifts (d's) and widths (HWHM's, w's) were measured from the line core of computed full spectral-line shapes for the Ar-perturbed/K-radiator system (K/Ar). The initial state of our model was based on a 4p 2 P 3/2,1/2 pseudo-potential for the K/Ar system, and the final state on a zero potential. The Fourier transform of the line shape formed the basis for the computations. Excellent agreement was found between the QM and SC values of d and of w in a high-pressure (P) non-impact region, which was characterized by a √P dependence of w and a P dependence of d. These agreements were shown to be another example of a correspondence between classical (SC) quantities and QM quantities in the limit of large quantum numbers. Typically at P=1x10 6 Torr and T=400 K, w QM =448 cm -1 and w SC =479 cm -1 , where the deviation from the mean is ±3.3%. Also, d QM =-3815 cm -1 and d SC =-3716 cm -1 , where the deviation from the mean is ±1.3%. A new general method was formulated which yielded a definite pressure P 0 , which was defined as an upper limit to the low-pressure impact approximation and a lower limit to the non-impact region

  5. Phase shift analysis of hyperon-nucleon elastic scattering using optimized polynomial expansion techniques

    Mohanty, S.; Deo, B.B.; Mohapatra, J.K.

    1986-01-01

    A relatively stable method of phase shift analysis of hyperon-nucleon scattering is proposed and applied to Σ + p and Λp scattering. The analytic cut t-planes of analyticity of the helicity amplitudes are mapped into the interior of unifocal ellipses. The helicity amplitudes are then expressed as accelerated convergent expansions in the mapped variable. A definite economy is observed in the number of free parameters for fixed energy phase shift analysis of Σ + p and Λp scattering at 40 and 100 MeV and 100 MeV respectively. Twenty six more phase shifts and coupling parameters corresponding to higher J values are also predicted. (author)

  6. GENOVA: a generalized perturbation theory program for various applications to CANDU core physics analysis (I)-theory and application

    Kim, Do Heon; Choi, Hang Bok

    2001-01-01

    A generalized perturbation theory (GPT) program, GENOVA, has been developed for the purpose of various applications to Canadian deuterium uranium (CANDU) reactor physics analyses. GENOVA was written under the framework of CANDU physics design and analysis code, RFSP. A sensitivity method based on the GPT was implemented in GENOVA to estimate various sensitivity coefficients related to the movement of zone controller units (ZCUs) existing in the CANDU reactor. The numerical algorithm for the sensitivity method was verified by a simple 2 x 2 node problem. The capability of predicting ZCU levels upon a refueling perturbation was validated for a CANDU-6 reactor problem. The applicability of GENOVA to the CANDU-6 core physics analysis has been demonstrated with the optimum refueling simulation and the uncertainty analysis problems. For the optimum refueling simulation, an optimum channel selection strategy has been proposed, using the ZCU level predicted by GENOVA. The refueling simulation of a CANDU-6 natural uranium core has shown that the ZCU levels are successfully controlled within the operating range while the channel and bundle powers are satisfying the license limits. An uncertainty analysis has been performed for the fuel composition heterogeneity of a CANDU DUPIC core, using the sensitivity coefficients generated by GENOVA. The results have shown that the uncertainty of the core performance parameter can be reduced appreciably when the contents of the major fissile isotopes are tightly controlled. GENOVA code has been successfully explored to supplement the weak points of the current design and analysis code, such as the incapacity of performing an optimum refueling simulation and uncertainty analysis. The sample calculations have shown that GENOVA has strong potential to be used for CANDU core analysis combined with the current design and analysis code, RFSP, especially for the development of advanced CANDU fuels

  7. Night-shift work and breast cancer--a systematic review and meta-analysis.

    Ijaz, Sharea; Verbeek, Jos; Seidler, Andreas; Lindbohm, Marja-Liisa; Ojajärvi, Anneli; Orsini, Nicola; Costa, Giovanni; Neuvonen, Kaisa

    2013-09-01

    The aim of this review was to synthesize the evidence on the potential relationship between nightshift work and breast cancer. We searched multiple databases for studies comparing women in shift work to those with no-shift work reporting incidence of breast cancer. We calculated incremental risk ratios (RR) per five years of night-shift work and per 300 night shift increases in exposure and combined these in a random effects dose-response meta-analysis. We assessed study quality in ten domains of bias. We identified 16 studies: 12 case-control and 4 cohort studies. There was a 9% risk increase per five years of night-shift work exposure in case-control studies [RR 1.09, 95% confidence interval (95% CI) 1.02-1.20; I (2) = 37%, 9 studies], but not in cohort studies (RR 1.01, 95% CI 0.97-1.05; I (2) = 53%, 3 studies). Heterogeneity was significant overall (I (2) = 55%, 12 studies). Results for 300 night shifts were similar (RR 1.04, 95% CI 1.00-1.10; I (2) = 58%, 8 studies). Sensitivity analysis using exposure transformations such as cubic splines, a fixed-effect model, or including only better quality studies did not change the results. None of the 16 studies had a low risk of bias, and 6 studies had a moderate risk. Based on the low quality of exposure data and the difference in effect by study design, our findings indicate insufficient evidence for a link between night-shift work and breast cancer. Objective prospective exposure measurement is needed in future studies.

  8. Qualitative analysis and traveling wave solutions for the perturbed nonlinear Schroedinger's equation with Kerr law nonlinearity

    Zhang Zaiyun; Liu Zhenhai; Miao Xiujin; Chen Yuezhong

    2011-01-01

    In this Letter, we investigate the perturbed nonlinear Schroedinger's equation (NLSE) with Kerr law nonlinearity. All explicit expressions of the bounded traveling wave solutions for the equation are obtained by using the bifurcation method and qualitative theory of dynamical systems. These solutions contain bell-shaped solitary wave solutions, kink-shaped solitary wave solutions and Jacobi elliptic function periodic solutions. Moreover, we point out the region which these periodic wave solutions lie in. We present the relation between the bounded traveling wave solution and the energy level h. We find that these periodic wave solutions tend to the corresponding solitary wave solutions as h increases or decreases. Finally, for some special selections of the energy level h, it is shown that the exact periodic solutions evolute into solitary wave solution.

  9. Second order classical perturbation theory for atom surface scattering: Analysis of asymmetry in the angular distribution

    Zhou, Yun, E-mail: zhou.yun.x@gmail.com; Pollak, Eli, E-mail: eli.pollak@weizmann.ac.il [Chemical Physics Department, Weizmann Institute of Science, 76100 Rehovot (Israel); Miret-Artés, Salvador, E-mail: s.miret@iff.csic.es [Instituto de Fisica Fundamental, Consejo Superior de Investigaciones Cientificas, Serrano 123, 28006 Madrid (Spain)

    2014-01-14

    A second order classical perturbation theory is developed and applied to elastic atom corrugated surface scattering. The resulting theory accounts for experimentally observed asymmetry in the final angular distributions. These include qualitative features, such as reduction of the asymmetry in the intensity of the rainbow peaks with increased incidence energy as well as the asymmetry in the location of the rainbow peaks with respect to the specular scattering angle. The theory is especially applicable to “soft” corrugated potentials. Expressions for the angular distribution are derived for the exponential repulsive and Morse potential models. The theory is implemented numerically to a simplified model of the scattering of an Ar atom from a LiF(100) surface.

  10. Analysis of RSG-GAS Control Rod Worth Due to Perturbation Reactivity

    Taswanda Taryo

    2004-01-01

    The control rod interaction effect of RSG-GAS typical working core was studied using a method based on the exact perturbation theory with three simplifying assumptions which require only N+1 criticality calculations. The interaction effect between two interacting rods reached up to 19 % while the interaction effect of multiple interacting rods reached up to 32 % for all (8) control rods involved. The accuracy of the adopted method were extensively investigated to determine the error sources and the magnitude of the error. Through comparison of the present results with ones of the simple summation method, it was obvious that the adopted method was superior in that a significant improvement on the accuracy of the calculated reactivity worth can be achieved with a small number of criticality calculations. (author)

  11. On the conditions of exponential stability in active disturbance rejection control based on singular perturbation analysis

    Shao, S.; Gao, Z.

    2017-10-01

    Stability of active disturbance rejection control (ADRC) is analysed in the presence of unknown, nonlinear, and time-varying dynamics. In the framework of singular perturbations, the closed-loop error dynamics are semi-decoupled into a relatively slow subsystem (the feedback loop) and a relatively fast subsystem (the extended state observer), respectively. It is shown, analytically and geometrically, that there exists a unique exponential stable solution if the size of the initial observer error is sufficiently small, i.e. in the same order of the inverse of the observer bandwidth. The process of developing the uniformly asymptotic solution of the system reveals the condition on the stability of the ADRC and the relationship between the rate of change in the total disturbance and the size of the estimation error. The differentiability of the total disturbance is the only assumption made.

  12. Thermal analysis of dry eye subjects and the thermal impulse perturbation model of ocular surface.

    Zhang, Aizhong; Maki, Kara L; Salahura, Gheorghe; Kottaiyan, Ranjini; Yoon, Geunyoung; Hindman, Holly B; Aquavella, James V; Zavislan, James M

    2015-03-01

    In this study, we explore the usage of ocular surface temperature (OST) decay patterns to distinguished between dry eye patients with aqueous deficient dry eye (ADDE) and meibomian gland dysfunction (MGD). The OST profiles of 20 dry eye subjects were measured by a long-wave infrared thermal camera in a standardized environment (24 °C, and relative humidity (RH) 40%). The subjects were instructed to blink every 5 s after 20 ∼ 25 min acclimation. Exponential decay curves were fit to the average temperature within a region of the central cornea. We find the MGD subjects have both a higher initial temperature (p model, referred to as the thermal impulse perturbation (TIP) model. We conclude that long-wave-infrared thermal imaging is a plausible tool in assisting with the classification of dry eye patient. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Second order classical perturbation theory for atom surface scattering: analysis of asymmetry in the angular distribution.

    Zhou, Yun; Pollak, Eli; Miret-Artés, Salvador

    2014-01-14

    A second order classical perturbation theory is developed and applied to elastic atom corrugated surface scattering. The resulting theory accounts for experimentally observed asymmetry in the final angular distributions. These include qualitative features, such as reduction of the asymmetry in the intensity of the rainbow peaks with increased incidence energy as well as the asymmetry in the location of the rainbow peaks with respect to the specular scattering angle. The theory is especially applicable to "soft" corrugated potentials. Expressions for the angular distribution are derived for the exponential repulsive and Morse potential models. The theory is implemented numerically to a simplified model of the scattering of an Ar atom from a LiF(100) surface.

  14. Perturbation analysis of spontaneous action potential initiation by stochastic ion channels

    Keener, James P.

    2011-07-01

    A stochastic interpretation of spontaneous action potential initiation is developed for the Morris-Lecar equations. Initiation of a spontaneous action potential can be interpreted as the escape from one of the wells of a double well potential, and we develop an asymptotic approximation of the mean exit time using a recently developed quasistationary perturbation method. Using the fact that the activating ionic channel\\'s random openings and closings are fast relative to other processes, we derive an accurate estimate for the mean time to fire an action potential (MFT), which is valid for a below-threshold applied current. Previous studies have found that for above-threshold applied current, where there is only a single stable fixed point, a diffusion approximation can be used. We also explore why different diffusion approximation techniques fail to estimate the MFT. © 2011 American Physical Society.

  15. Genome wide expression analysis suggests perturbation of vascular homeostasis during high altitude pulmonary edema.

    Manish Sharma

    Full Text Available BACKGROUND: High altitude pulmonary edema (HAPE is a life-threatening form of non-cardiogenic edema which occurs in unacclimatized but otherwise normal individuals within two to four days after rapid ascent to altitude beyond 3000 m. The precise pathoetiology and inciting mechanisms regulating HAPE remain unclear. METHODOLOGY/PRINCIPLE FINDINGS: We performed global gene expression profiling in individuals with established HAPE compared to acclimatized individuals. Our data suggests concurrent modulation of multiple pathways which regulate vascular homeostasis and consequently lung fluid dynamics. These pathways included those which regulate vasoconstriction through smooth muscle contraction, cellular actin cytoskeleton rearrangements and endothelial permeability/dysfunction. Some notable genes within these pathways included MYLK; rho family members ARGEF11, ARHGAP24; cell adhesion molecules such as CLDN6, CLDN23, PXN and VCAM1 besides other signaling intermediates. Further, several important regulators of systemic/pulmonary hypertension including ADRA1D, ECE1, and EDNRA were upregulated in HAPE. We also observed significant upregulation of genes involved in paracrine signaling through chemokines and lymphocyte activation pathways during HAPE represented by transcripts of TNF, JAK2, MAP2K2, MAP2K7, MAPK10, PLCB1, ARAF, SOS1, PAK3 and RELA amongst others. Perturbation of such pathways can potentially skew vascular homeostatic equilibrium towards altered vascular permeability. Additionally, differential regulation of hypoxia-sensing, hypoxia-response and OXPHOS pathway genes in individuals with HAPE were also observed. CONCLUSIONS/SIGNIFICANCE: Our data reveals specific components of the complex molecular circuitry underlying HAPE. We show concurrent perturbation of multiple pathways regulating vascular homeostasis and suggest multi-genic nature of regulation of HAPE.

  16. Charge-symmetry-breaking effects from phase-shift analysis of elastic πsup(+-4)He scattering

    Khankhasayev, M.Kh.; Nichitiu, F.; Sapozhnikov, M.G.

    1986-01-01

    A phase-shift analysis of elastic πsup(+-4)He scattering at energies 20-160 MeV was performed to determine pure hadronic phase shifts. No statistically significant difference between the hadronic phase shifts deduced from π +4 He and π -4 He scattering was observed. (orig.)

  17. Shift work, long working hours and preterm birth: a systematic review and meta-analysis

    van Melick, M. J. G. J.; Van Beukering, M. D. M.; Mol, B. W.; Frings-Dresen, M. H. W.; Hulshof, C. T. J.

    2014-01-01

    Specific physical activities or working conditions are suspected for increasing the risk of preterm birth (PTB). The aim of this meta-analysis is to review and summarize the pre-existing evidence on the effect of shift work or long working hours on the risk of PTB. We conducted a systematic search

  18. Analysis of the differential-phase-shift-keying protocol in the quantum-key-distribution system

    Rong-Zhen, Jiao; Chen-Xu, Feng; Hai-Qiang, Ma

    2009-01-01

    The analysis is based on the error rate and the secure communication rate as functions of distance for three quantum-key-distribution (QKD) protocols: the Bennett–Brassard 1984, the Bennett–Brassard–Mermin 1992, and the coherent differential-phase-shift keying (DPSK) protocols. We consider the secure communication rate of the DPSK protocol against an arbitrary individual attack, including the most commonly considered intercept-resend and photon-number splitting attacks, and concluded that the simple and efficient differential-phase-shift-keying protocol allows for more than 200 km of secure communication distance with high communication rates. (general)

  19. Quantitative evaluation of the pivot shift by image analysis using the iPad.

    Hoshino, Yuichi; Araujo, Paulo; Ahldén, Mattias; Samuelsson, Kristian; Muller, Bart; Hofbauer, Marcus; Wolf, Megan R; Irrgang, James J; Fu, Freddie H; Musahl, Volker

    2013-04-01

    To enable comparison of test results, a widely available measurement system for the pivot shift test is needed. Simple image analysis of lateral knee joint translation is one such system that can be installed on a prevalent computer tablet (e.g. iPad). The purpose of this study was to test a novel iPad application to detect the pivot shift. It was hypothesized that the abnormal lateral translation in ACL deficient knees would be detected by the iPad application. Thirty-four consecutive ACL deficient patients were tested. Three skin markers were attached on the following bony landmarks: (1) Gerdy's tubercle, (2) fibular head and (3) lateral epicondyle. A standardized pivot shift test was performed under anaesthesia, while the lateral side of the knee joint was monitored. The recorded movie was processed by the iPad application to measure the lateral translation of the knee joint. Lateral translation was compared between knees with different pivot shift grades. Valid data sets were obtained in 20 (59 %) ACL deficient knees. The remaining 14 data sets were invalid because of failure to detect translation or detection of excessive translation. ACL deficient knees had larger lateral translation than the contra-lateral knees (p iPad application, the potential of the iPad application to classify the pivot shift was demonstrated.

  20. Meta-analysis on night shift work and risk of metabolic syndrome.

    Wang, F; Zhang, L; Zhang, Y; Zhang, B; He, Y; Xie, S; Li, M; Miao, X; Chan, E Y Y; Tang, J L; Wong, M C S; Li, Z; Yu, I T S; Tse, L A

    2014-09-01

    This study aims to quantitatively summarize the association between night shift work and the risk of metabolic syndrome (MetS), with special reference to the dose-response relationship with years of night shift work. We systematically searched all observational studies published in English on PubMed and Embase from 1971 to 2013. We extracted effect measures (relative risk, RR; or odd ratio, OR) with 95% confidence interval (CI) from individual studies to generate pooled results using meta-analysis approach. Pooled RR was calculated using random- or fixed-effect model. Downs and Black scale was applied to assess the methodological quality of included studies. A total of 13 studies were included. The pooled RR for the association between 'ever exposed to night shift work' and MetS risk was 1.57 (95% CI = 1.24-1.98, pheterogeneity  = 0.001), while a higher risk was indicated in workers with longer exposure to night shifts (RR = 1.77, 95% CI = 1.32-2.36, pheterogeneity  = 0.936). Further stratification analysis demonstrated a higher pooled effect of 1.84 (95% CI = 1.45-2.34) for studies using the NCEP-ATPIII criteria, among female workers (RR = 1.61, 95% CI = 1.10-2.34) and the countries other than Asia (RR = 1.65, 95% CI = 1.39-1.95). Sensitivity analysis confirmed the robustness of the results. No evidence of publication bias was detected. The present meta-analysis suggested that night shift work is significantly associated with the risk of MetS, and a positive dose-response relationship with duration of exposure was indicated. © 2014 The Authors. obesity reviews © 2014 World Obesity.

  1. Analysis of Underactuated Dynamic Locomotion Systems Using Perturbation Expansion: The Twistcar Toy Example

    Chakon, Ofir; Or, Yizhar

    2017-08-01

    Underactuated robotic locomotion systems are commonly represented by nonholonomic constraints where in mixed systems, these constraints are also combined with momentum evolution equations. Such systems have been analyzed in the literature by exploiting symmetries and utilizing advanced geometric methods. These works typically assume that the shape variables are directly controlled, and obtain the system's solutions only via numerical integration. In this work, we demonstrate utilization of the perturbation expansion method for analyzing a model example of mixed locomotion system—the twistcar toy vehicle, which is a variant of the well-studied roller-racer model. The system is investigated by assuming small-amplitude oscillatory inputs of either steering angle (kinematic) or steering torque (mechanical), and explicit expansions for the system's solutions under both types of actuation are obtained. These expressions enable analyzing the dependence of the system's dynamic behavior on the vehicle's structural parameters and actuation type. In particular, we study the reversal in direction of motion under steering angle oscillations about the unfolded configuration, as well as influence of the choice of actuation type on convergence properties of the motion. Some of the findings are demonstrated qualitatively by reporting preliminary motion experiments with a modular robotic prototype of the vehicle.

  2. Performance analysis of ‘Perturb and Observe’ and ‘Incremental Conductance’ MPPT algorithms for PV system

    Lodhi, Ehtisham; Lodhi, Zeeshan; Noman Shafqat, Rana; Chen, Fieda

    2017-07-01

    Photovoltaic (PV) system usually employed The Maximum power point tracking (MPPT) techniques for increasing its efficiency. The performance of the PV system perhaps boosts by controlling at its apex point of power, in this way maximal power can be given to load. The proficiency of a PV system usually depends upon irradiance, temperature and array architecture. PV array shows a non-linear style for V-I curve and maximal power point on V-P curve also varies with changing environmental conditions. MPPT methods grantees that a PV module is regulated at reference voltage and to produce entire usage of the maximal output power. This paper gives analysis between two widely employed Perturb and Observe (P&O) and Incremental Conductance (INC) MPPT techniques. Their performance is evaluated and compared through theoretical analysis and digital simulation on the basis of response time and efficiency under varying irradiance and temperature condition using Matlab/Simulink.

  3. Causal functional contributions and interactions in the attention network of the brain: an objective multi-perturbation analysis.

    Zavaglia, Melissa; Hilgetag, Claus C

    2016-06-01

    Spatial attention is a prime example for the distributed network functions of the brain. Lesion studies in animal models have been used to investigate intact attentional mechanisms as well as perspectives for rehabilitation in the injured brain. Here, we systematically analyzed behavioral data from cooling deactivation and permanent lesion experiments in the cat, where unilateral deactivation of the posterior parietal cortex (in the vicinity of the posterior middle suprasylvian cortex, pMS) or the superior colliculus (SC) cause a severe neglect in the contralateral hemifield. Counterintuitively, additional deactivation of structures in the opposite hemisphere reverses the deficit. Using such lesion data, we employed a game-theoretical approach, multi-perturbation Shapley value analysis (MSA), for inferring functional contributions and network interactions of bilateral pMS and SC from behavioral performance in visual attention studies. The approach provides an objective theoretical strategy for lesion inferences and allows a unique quantitative characterization of regional functional contributions and interactions on the basis of multi-perturbations. The quantitative analysis demonstrated that right posterior parietal cortex and superior colliculus made the strongest positive contributions to left-field orienting, while left brain regions had negative contributions, implying that their perturbation may reverse the effects of contralateral lesions or improve normal function. An analysis of functional modulations and interactions among the regions revealed redundant interactions (implying functional overlap) between regions within each hemisphere, and synergistic interactions between bilateral regions. To assess the reliability of the MSA method in the face of variable and incomplete input data, we performed a sensitivity analysis, investigating how much the contribution values of the four regions depended on the performance of specific configurations and on the

  4. Analysis of Shift and Deformation of Planar Surfaces Using the Least Squares Plane

    Hrvoje Matijević

    2006-12-01

    Full Text Available Modern methods of measurement developed on the basis of advanced reflectorless distance measurement have paved the way for easier detection and analysis of shift and deformation. A large quantity of collected data points will often require a mathematical model of the surface that fits best into these. Although this can be a complex task, in the case of planar surfaces it is easily done, enabling further processing and analysis of measurement results. The paper describes the fitting of a plane to a set of collected points using the least squares distance, with previously excluded outliers via the RANSAC algorithm. Based on that, a method for analysis of the deformation and shift of planar surfaces is also described.

  5. Robust synchronization analysis in nonlinear stochastic cellular networks with time-varying delays, intracellular perturbations and intercellular noise.

    Chen, Po-Wei; Chen, Bor-Sen

    2011-08-01

    Naturally, a cellular network consisted of a large amount of interacting cells is complex. These cells have to be synchronized in order to emerge their phenomena for some biological purposes. However, the inherently stochastic intra and intercellular interactions are noisy and delayed from biochemical processes. In this study, a robust synchronization scheme is proposed for a nonlinear stochastic time-delay coupled cellular network (TdCCN) in spite of the time-varying process delay and intracellular parameter perturbations. Furthermore, a nonlinear stochastic noise filtering ability is also investigated for this synchronized TdCCN against stochastic intercellular and environmental disturbances. Since it is very difficult to solve a robust synchronization problem with the Hamilton-Jacobi inequality (HJI) matrix, a linear matrix inequality (LMI) is employed to solve this problem via the help of a global linearization method. Through this robust synchronization analysis, we can gain a more systemic insight into not only the robust synchronizability but also the noise filtering ability of TdCCN under time-varying process delays, intracellular perturbations and intercellular disturbances. The measures of robustness and noise filtering ability of a synchronized TdCCN have potential application to the designs of neuron transmitters, on-time mass production of biochemical molecules, and synthetic biology. Finally, a benchmark of robust synchronization design in Escherichia coli repressilators is given to confirm the effectiveness of the proposed methods. Copyright © 2011 Elsevier Inc. All rights reserved.

  6. Analysis of stochastic magnetic fields formed by the application of resonant magnetic perturbations on MAST and comparison with experiment

    Denner, P.; Liu, Yueqiang; Kirk, A.; Nardon, E.

    2012-01-01

    In MAST experiments with applied resonant magnetic perturbations (RMPs), clear reduction in line-averaged density has been observed in a wide range of L-mode plasmas when there is an alignment between the perturbation and the equilibrium magnetic field that maximizes the size of the resonant components of the applied magnetic field, as well as in a few H-mode plasmas but with a much stronger sensitivity to this alignment. This density pump-out is the result of increased particle transport, which is thought to be caused by the formation of a stochastic magnetic field in the plasma edge. This paper presents an analysis of the magnetic field structures formed by the application of n = 3 RMPs on MAST, including various parameters characterizing the degree of stochasticity in the plasma edge. Values for these parameters are calculated and compared with the amount of density pump-out observed in MAST experiments. It is found that density pump-out is fairly well correlated with some of the parameters calculated using vacuum modelling, but none of them provides a single threshold value for pump-out that applies to both L- and H-mode plasmas. Plasma response modelling provides a robust criterion for density pump-out that applies both to L- and H-mode plasmas. (paper)

  7. Phase-shift analysis in pion-/sup 4/He elastic scattering. [60 to 260 MeV

    Falomkin, I V; Nichitiu, F; Sapozhnikov, M G; Shcherbakov, YU A [Joint Inst. for Nuclear Research, Dubna (USSR); Balestra, F; Bollini, E [Turin Univ. (Italy). Istituto di Fisica

    1978-02-21

    An energy-independent phase-shift analysis (PSA) of the elastic scattering of pions on /sup 4/He, in the energy range 60 to 260 MeV has been performed. All possible solutions, arising from the phase-shift analysis ambiguity, have been analyzed. Particular care has been taken in the choice of the physical solution. The calculated phase shifts have been compared with the results of the energy-dependent phase-shift analysis (EDPSA) and with the optical-model predictions.

  8. Perturbative anyon gas

    Dasnieres de Veigy, A.; Ouvry, S.; Paris-6 Univ., 75

    1992-06-01

    The problem of the statistical mechanics of an anyon gas is addressed. A perturbative analysis in the anyonic coupling constant α is reviewed, and the thermodynamical potential is computed at first and second order. An adequate second quantized formalism (field theory at finite temperature) is proposed. At first order in perturbation theory, the results are strikingly simple: only the second virial coefficient close to bosonic statistics is corrected. At second order, however, the complexity of the anyon model appears. One can compute exactly the perturbative correction to each cluster coefficient. However, and contrary to first order, a closed expression for the equation of state seems out of reach. As an illustration, the perturbative expressions of a 3 , a 4 , a 5 and a 6 are given at second order. Finally, using the same formalism, the equation of state of an anyon gas in a constant magnetic field is analyzed at first order in perturbation theory. (K.A.) 16 refs.; 3 figs.; 7 tabs

  9. Perturbed Markov chains

    Solan, Eilon; Vieille, Nicolas

    2015-01-01

    We study irreducible time-homogenous Markov chains with finite state space in discrete time. We obtain results on the sensitivity of the stationary distribution and other statistical quantities with respect to perturbations of the transition matrix. We define a new closeness relation between transition matrices, and use graph-theoretic techniques, in contrast with the matrix analysis techniques previously used.

  10. Influence of shift work on early reproductive outcomes: a systematic review and meta-analysis.

    Stocker, Linden J; Macklon, Nicholas S; Cheong, Ying C; Bewley, Susan J

    2014-07-01

    To determine whether an association exists between shift work and early reproductive outcomes. MEDLINE, Embase, and Web of Science were searched. Additional sources included Google Scholar, the Cochrane Library, online publications of national colleges, the ClinicalTrials.gov, and references of retrieved papers. Included studies compared female shift workers (work outside 8:00 AM to 6:00 PM) with nonshift workers with menstrual disruption (cycles less than 25 days or greater than 31 days), infertility (time-to-pregnancy exceeding 12 months), or early spontaneous pregnancy loss (less than 25 weeks). Two reviewers extracted adjusted and raw data. Random effect models were used to pool data weighting for the inverse of variance. Assessments of heterogeneity, bias, and subgroup analyses were performed. Sixteen independent cohorts from 15 studies (123,403 women) were subject to analysis. Shift workers had increased rates of menstrual disruption (16.05% [2,207/13,749] compared with 13.05% [7,561/57,932] [n=71.681, odds ratio {OR} 1.22, 95% confidence interval {CI} 1.15-1.29, I 0%]) and infertility (11.3% [529/4,668] compared with 9.9% [2,354/23,811] [OR 1.80, 95% CI 1.01-3.20, I 94%]) but not early spontaneous pregnancy loss (11.84% [939/7,931] compared with 12.11% [1,898/15,673] [n=23,604, OR 0.96, 95% CI 0.88-1.05, I 0%]). Night shifts were associated with increased early spontaneous pregnancy loss (n=13,018, OR 1.29, 95% CI 1.11-1.50, I 0%). Confounder adjustment led to persistent relationships between shift work and menstrual disruption (adjusted OR 1.15, 95% CI 1.01-1.31, I 70%) but not infertility (adjusted OR 1.11 95% CI 0.86-1.44, I 61%). The association between night shifts and early spontaneous pregnancy loss remained (adjusted OR 1.41 95% CI 1.22-1.63, I 0%). This review provides evidence for an association between performing shift work and early reproductive outcomes, consistent with later pregnancy findings. However, there is currently insufficient evidence

  11. Shift work, long working hours and preterm birth: a systematic review and meta-analysis.

    van Melick, M J G J; van Beukering, M D M; Mol, B W; Frings-Dresen, M H W; Hulshof, C T J

    2014-11-01

    Specific physical activities or working conditions are suspected for increasing the risk of preterm birth (PTB). The aim of this meta-analysis is to review and summarize the pre-existing evidence on the effect of shift work or long working hours on the risk of PTB. We conducted a systematic search in MEDLINE and EMBASE (1990-2013) for observational and intervention studies with original data. We only included articles that met our specific criteria for language, exposure, outcome, data collection and original data that were of at least of moderate quality. The data of the included studies were pooled. Eight high-quality studies and eight moderate-quality studies were included in the meta-analysis. In these studies, no clear or statistically significant relationship between shift work and PTB was found. The summary estimate OR for performing shift work during pregnancy and the risk of PTB were 1.04 (95% CI 0.90-1.20). For long working hours during pregnancy, the summary estimate OR was 1.25 (95% CI 1.01-1.54), indicating a marginally statistically significant relationship but an only slightly elevated risk. Although in many of the included studies a positive association between long working hours and PTB was seen this did reach only marginal statistical significance. In the studies included in this review, working in shifts or in night shifts during pregnancy was not significantly associated with an increased risk for PTB. For both risk factors, due to the lack of high-quality studies focusing on the risks per trimester, in particular the third trimester, a firm conclusion about an association cannot be stated.

  12. Singular perturbation of simple eigenvalues

    Greenlee, W.M.

    1976-01-01

    Two operator theoretic theorems which generalize those of asymptotic regular perturbation theory and which apply to singular perturbation problems are proved. Application of these theorems to concrete problems is involved, but the perturbation expansions for eigenvalues and eigenvectors are developed in terms of solutions of linear operator equations. The method of correctors, as well as traditional boundary layer techniques, can be used to apply these theorems. The current formulation should be applicable to highly singular ''hard core'' potential perturbations of the radial equation of quantum mechanics. The theorems are applied to a comparatively simple model problem whose analysis is basic to that of the quantum mechanical problem

  13. Analysis of optical band-gap shift in impurity doped ZnO thin films by using nonparabolic conduction band parameters

    Kim, Won Mok; Kim, Jin Soo; Jeong, Jeung-hyun; Park, Jong-Keuk; Baik, Young-Jun; Seong, Tae-Yeon

    2013-01-01

    Polycrystalline ZnO thin films both undoped and doped with various types of impurities, which covered the wide carrier concentration range of 10 16 –10 21 cm −3 , were prepared by magnetron sputtering, and their optical-band gaps were investigated. The experimentally measured optical band-gap shifts were analyzed by taking into account the carrier density dependent effective mass determined by the first-order nonparabolicity approximation. It was shown that the measured shifts in optical band-gaps in ZnO films doped with cationic dopants, which mainly perturb the conduction band, could be well represented by theoretical estimation in which the band-gap widening due to the band-filling effect and the band-gap renormalization due to the many-body effect derived for a weakly interacting electron-gas model were combined and the carrier density dependent effective mass was incorporated. - Highlights: ► Optical band-gaps of polycrystalline ZnO thin films were analyzed. ► Experimental carrier concentration range covered from 10 16 to 10 21 cm −3 . ► Nonparabolic conduction band parameters were used in theoretical analysis. ► The band-filling and the band-gap renormalization effects were considered. ► The measured optical band-gap shifts corresponded well with the calculated ones

  14. Stochastic multi-scale analysis of homogenised properties considering uncertainties in cellular solid microstructures using a first-order perturbation

    Khairul Salleh Basaruddin

    Full Text Available Randomness in the microstructure due to variations in microscopic properties and geometrical information is used to predict the stochastically homogenised properties of cellular media. Two stochastic problems at the micro-scale level that commonly occur due to fabrication inaccuracies, degradation mechanisms or natural heterogeneity were analysed using a stochastic homogenisation method based on a first-order perturbation. First, the influence of Young's modulus variation in an adhesive on the macroscopic properties of an aluminium-adhesive honeycomb structure was investigated. The fluctuations in the microscopic properties were then combined by varying the microstructure periodicity in a corrugated-core sandwich plate to obtain the variation of the homogenised property. The numerical results show that the uncertainties in the microstructure affect the dispersion of the homogenised property. These results indicate the importance of the presented stochastic multi-scale analysis for the design and fabrication of cellular solids when considering microscopic random variation.

  15. On dark energy isocurvature perturbation

    Liu, Jie; Zhang, Xinmin; Li, Mingzhe

    2011-01-01

    Determining the equation of state of dark energy with astronomical observations is crucially important to understand the nature of dark energy. In performing a likelihood analysis of the data, especially of the cosmic microwave background and large scale structure data the dark energy perturbations have to be taken into account both for theoretical consistency and for numerical accuracy. Usually, one assumes in the global fitting analysis that the dark energy perturbations are adiabatic. In this paper, we study the dark energy isocurvature perturbation analytically and discuss its implications for the cosmic microwave background radiation and large scale structure. Furthermore, with the current astronomical observational data and by employing Markov Chain Monte Carlo method, we perform a global analysis of cosmological parameters assuming general initial conditions for the dark energy perturbations. The results show that the dark energy isocurvature perturbations are very weakly constrained and that purely adiabatic initial conditions are consistent with the data

  16. Motion as perturbation. II. Development of the method for dosimetric analysis of motion effects with fixed-gantry IMRT

    Nelms, Benjamin E. [Canis Lupus LLC, Merrimac, Wisconsin 53561 (United States); Opp, Daniel; Zhang, Geoffrey; Moros, Eduardo; Feygelman, Vladimir, E-mail: vladimir.feygelman@moffitt.org [Department of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida 33612 (United States)

    2014-06-15

    was 5 s, with the resulting average motion speed of 1.45 cm/s. The motion-perturbed high resolution (2 mm voxel) volumetric dose grids on the MC2 phantom were generated for each beam. From each grid, a coronal dose plane at the detector level was extracted and compared to the corresponding moving MC2 measurement, using gamma analysis with both global (G) and local (L) dose-error normalization. Results: Using the TG-119 criteria of (3%G/3 mm), per beam average gamma analysis passing rates exceeded 95% in all cases. No individual beam had a passing rate below 91%. LDVE correction eliminated systematic disagreement patterns at the beams’ aperture edges. In a representative example, application of LDVE correction improved (2%L/2 mm) gamma analysis passing rate for an IMRT beam from 74% to 98%. Conclusions: The effect of motion on the moving region-of-interest IMRT dose can be estimated with a standard, static phantom QA measurement, provided the motion characteristics are independently known from 4D CT or otherwise. The motion-perturbed absolute dose estimates were validated by the direct planar diode array measurements, and were found to reliably agree with them in a homogeneous phantom.

  17. Parameter design and performance analysis of shift actuator for a two-speed automatic mechanical transmission for pure electric vehicles

    Jianjun Hu

    2016-08-01

    Full Text Available Recent developments of pure electric vehicles have shown that pure electric vehicles equipped with two-speed or multi-speed gearbox possess higher energy efficiency by ensuring the drive motor operates at its peak performance range. This article presents the design, analysis, and control of a two-speed automatic mechanical transmission for pure electric vehicles. The shift actuator is based on a motor-controlled camshaft where a special geometric groove is machined, and the camshaft realizes the axial positions of the synchronizer sleeve for gear engaging, disengaging, and speed control of the drive motor. Based on the force analysis of shift process, the parameters of shift actuator and shift motor are designed. The drive motor’s torque control strategy before shifting, speed governing control strategy before engaging, shift actuator’s control strategy during gear engaging, and drive motor’s torque recovery strategy after shift process are proposed and implemented with a prototype. To validate the performance of the two-speed gearbox, a test bed was developed based on dSPACE that emulates various operation conditions. The experimental results indicate that the shift process with the proposed shift actuator and control strategy could be accomplished within 1 s under various operation conditions, with shift smoothness up to passenger car standard.

  18. In Silico analysis of perturbed steroidogenesis and gonad growth in fathead minnows (P. promelas) exposed to 17α-ethynylestradiol.

    Hala, David; Petersen, Lene H; Martinović, Dalma; Huggett, Duane B

    2015-06-01

    The multi-factorial nature of adverse reproductive effects mediated by endocrine disrupting compounds (or EDCs) makes understanding the mechanistic basis of reproductive dysfunction a highly pertinent area of research. As a consequence, a main motivator for continued research is to integrate 'multi-leveled' complexity (i.e., from genes to phenotype) using mathematical methods capable of encapsulating properties of physiological relevance. In this study, an in silico stoichiometric model of piscine steroidogenesis was augmented with a 'biomass' reaction associating the underlying stoichiometry of steroidogenesis with a reaction representative of gonad growth. The ability of the in silico model to predict perturbed steroidogenesis and subsequent effects on gonad growth was tested by exposing reproductively active male and female fathead minnows (Pimephales promelas) to 88 ng/L of the synthetic estrogen, 17α-ethynylestradiol (EE2). The in silico model was parameterized (or constrained) with experimentally quantified concentrations of selected steroid hormones (using mass spectrometry) and fold changes in gene expression (using RT-qPCR) for selected steroidogenic enzyme genes, in gonads of male and female fish. Once constrained, the optimization framework of flux balance analysis (FBA) was used to calculate an optimal flux through the biomass reaction (analogous to gonad growth) and associated steroidogenic flux distributions required to generate biomass. FBA successfully predicted effects of EE2 exposure on fathead minnow gonad growth (%gonadosomatic index or %GSI) and perturbed production of steroid hormones. Specifically, FBA accurately predicted no effects of exposure on male %GSI and a significant reduction for female %GSI. Furthermore, in silico simulations accurately identified disrupted reaction fluxes catalyzing productions of androgens (in male fish) and progestogens (in female fish), an observation which agreed with in vivo experimentation. The analyses

  19. Response coefficient analysis of a fed-batch bioreactor to dissolved oxygen perturbation in complementary cultures during PHB production

    Patnaik Pratap R

    2008-03-01

    Full Text Available Abstract Background Although the production of poly-β-hydroxybutyrate (PHB has many biological, energetic and environmental advantages over chemically synthesized polymers, synthetic polymers continue to be produced industrially since the productivities of fermentation processes fr PHB are not yet economically competitive. Improvement of a PHB fermentation requires good understanding and optimization under the realistic conditions of large bioreactors. Laboratory-scale studies have shown that co-cultures of Ralstonia eutropha and Lactobacillus delbrueckii generate better fermentation efficiencies than R. eutropha alone. In large bioreactors, incomplete dispersioin and perturbations in the dissolved oxygen (DO concentration, both of which affect the fermentation, have to be considered. This study analyzes the effect of DO fluctuations on bioreactor performance for both ideal and optimally dispersed broths. Results Response coefficient analysis was employed to obtain quantitative information on the effect of DO perturbations on different variables. Three values of the Peclet number (Pe cheracterized three levels of dispersion: Pe = 0.01 for nearly complete dispersion, Pe = 20 for optimum dispersion and Pe = 60 for insufficient dispersion. The response coefficients (RCs of the pairs of bacterial concentrations and the main substrates, glucose and ammonium chloride, showed contrasting variations with time. Lactate, a critical intermediate, and PHB had similar RC profiles but those of lactate were one to two orders of magnitude larger than other RCs. Significantly, the optimum Pe also resulted in the largest RCs, suggesting a balance between productivity and reactor stability. Conclusion Since R. eutropha requires oxygen for its growth whereas L. delbrueckii does not, fluctuations in the DO concentartion have a strong influence on the fermentation. Apart from this, the mechanism of PHB biosynthesis indicates that control of lactate is a critical

  20. PACSY, a relational database management system for protein structure and chemical shift analysis.

    Lee, Woonghee; Yu, Wookyung; Kim, Suhkmann; Chang, Iksoo; Lee, Weontae; Markley, John L

    2012-10-01

    PACSY (Protein structure And Chemical Shift NMR spectroscopY) is a relational database management system that integrates information from the Protein Data Bank, the Biological Magnetic Resonance Data Bank, and the Structural Classification of Proteins database. PACSY provides three-dimensional coordinates and chemical shifts of atoms along with derived information such as torsion angles, solvent accessible surface areas, and hydrophobicity scales. PACSY consists of six relational table types linked to one another for coherence by key identification numbers. Database queries are enabled by advanced search functions supported by an RDBMS server such as MySQL or PostgreSQL. PACSY enables users to search for combinations of information from different database sources in support of their research. Two software packages, PACSY Maker for database creation and PACSY Analyzer for database analysis, are available from http://pacsy.nmrfam.wisc.edu.

  1. PACSY, a relational database management system for protein structure and chemical shift analysis

    Lee, Woonghee, E-mail: whlee@nmrfam.wisc.edu [University of Wisconsin-Madison, National Magnetic Resonance Facility at Madison, and Biochemistry Department (United States); Yu, Wookyung [Center for Proteome Biophysics, Pusan National University, Department of Physics (Korea, Republic of); Kim, Suhkmann [Pusan National University, Department of Chemistry and Chemistry Institute for Functional Materials (Korea, Republic of); Chang, Iksoo [Center for Proteome Biophysics, Pusan National University, Department of Physics (Korea, Republic of); Lee, Weontae, E-mail: wlee@spin.yonsei.ac.kr [Yonsei University, Structural Biochemistry and Molecular Biophysics Laboratory, Department of Biochemistry (Korea, Republic of); Markley, John L., E-mail: markley@nmrfam.wisc.edu [University of Wisconsin-Madison, National Magnetic Resonance Facility at Madison, and Biochemistry Department (United States)

    2012-10-15

    PACSY (Protein structure And Chemical Shift NMR spectroscopY) is a relational database management system that integrates information from the Protein Data Bank, the Biological Magnetic Resonance Data Bank, and the Structural Classification of Proteins database. PACSY provides three-dimensional coordinates and chemical shifts of atoms along with derived information such as torsion angles, solvent accessible surface areas, and hydrophobicity scales. PACSY consists of six relational table types linked to one another for coherence by key identification numbers. Database queries are enabled by advanced search functions supported by an RDBMS server such as MySQL or PostgreSQL. PACSY enables users to search for combinations of information from different database sources in support of their research. Two software packages, PACSY Maker for database creation and PACSY Analyzer for database analysis, are available from http://pacsy.nmrfam.wisc.eduhttp://pacsy.nmrfam.wisc.edu.

  2. Bayesian Analysis of two Censored Shifted Gompertz Mixture Distributions using Informative and Noninformative Priors

    Tabassum Naz Sindhu

    2017-03-01

    Full Text Available This study deals with Bayesian analysis of shifted Gompertz mixture model under type-I censored samples assuming both informative and noninformative priors. We have discussed the Bayesian estimation of parameters of shifted Gompertz mixture model under the uniform, and gamma priors assuming three loss functions. Further, some properties of the model with some graphs of the mixture density are discussed. These properties include Bayes estimators, posterior risks and reliability function under simulation scheme. Bayes estimates are obtained considering two cases: (a when the shape parameter is known and (b when all parameters are unknown. We analyzed some simulated sets in order to investigate the effect of prior belief, loss functions, and performance of the proposed set of estimators of the mixture model parameters.

  3. On the analysis of the thermal line shift and thermal line width of ions in solids

    Walsh, Brian M., E-mail: brian.m.walsh@nasa.gov [NASA Langley Research Center, Hampton, VA 23681 (United States); Di Bartolo, Baldassare, E-mail: baldassare.dibartolo@bc.edu [Boston College, Department of Physics, Chestnut Hill, MA 23667 (United States)

    2015-02-15

    A method of analysis for the thermally induced line shift and line width of spectral lines regarding the Raman process of ions in solids utilizing rational approximations for the Debye functions is presented. The {sup 2}E level unsplit R-line in V{sup 2+}:MgO is used as an example to illustrate the utility of the methods discussed here in providing a new analytical tool for researchers. - Highlights: • We use rational approximations for Debye functions. • We discuss limits and ranges of applicability of the rational approximations. • We formulate expressions for thermal shift and thermal linewidth for Raman processes using the rational approximations of the Debye functions. • We present an application of the methods to analyze the temperature dependent linewidth and lineshift in V2+:MgO.

  4. PACSY, a relational database management system for protein structure and chemical shift analysis

    Lee, Woonghee; Yu, Wookyung; Kim, Suhkmann; Chang, Iksoo

    2012-01-01

    PACSY (Protein structure And Chemical Shift NMR spectroscopY) is a relational database management system that integrates information from the Protein Data Bank, the Biological Magnetic Resonance Data Bank, and the Structural Classification of Proteins database. PACSY provides three-dimensional coordinates and chemical shifts of atoms along with derived information such as torsion angles, solvent accessible surface areas, and hydrophobicity scales. PACSY consists of six relational table types linked to one another for coherence by key identification numbers. Database queries are enabled by advanced search functions supported by an RDBMS server such as MySQL or PostgreSQL. PACSY enables users to search for combinations of information from different database sources in support of their research. Two software packages, PACSY Maker for database creation and PACSY Analyzer for database analysis, are available from http://pacsy.nmrfam.wisc.edu. PMID:22903636

  5. PACSY, a relational database management system for protein structure and chemical shift analysis

    Lee, Woonghee; Yu, Wookyung; Kim, Suhkmann; Chang, Iksoo; Lee, Weontae; Markley, John L.

    2012-01-01

    PACSY (Protein structure And Chemical Shift NMR spectroscopY) is a relational database management system that integrates information from the Protein Data Bank, the Biological Magnetic Resonance Data Bank, and the Structural Classification of Proteins database. PACSY provides three-dimensional coordinates and chemical shifts of atoms along with derived information such as torsion angles, solvent accessible surface areas, and hydrophobicity scales. PACSY consists of six relational table types linked to one another for coherence by key identification numbers. Database queries are enabled by advanced search functions supported by an RDBMS server such as MySQL or PostgreSQL. PACSY enables users to search for combinations of information from different database sources in support of their research. Two software packages, PACSY Maker for database creation and PACSY Analyzer for database analysis, are available from http://pacsy.nmrfam.wisc.eduhttp://pacsy.nmrfam.wisc.edu.

  6. Analysis of the Market Structure and Shift-effects in North China Ports

    Manlu Liu, Doctoral Student

    2016-09-01

    Full Text Available This study divides the foreign trade traffic of major North China ports into export and import cargoes for the past 10 years. Then, the concentration ratios and shift effects are analyzed in order to determine their relationships with the ports’ competition structures. Here, the HHI, a BCG matrix analysis, and the shift effects are applied as study methods. The results indicate that the oligopoly market structure of major North China ports has gradually decreased. Furthermore, the concentration ratios of import cargoes are higher than those of export cargoes, indicating that competition to attract import cargoes will intensify. Therefore, the effects of the South Korea–China FTA mean that the competition structures of these ports with regard to export and import cargoes are highly likely to be differentiated further over time.

  7. Phase-shifting Real-time Holographic Microscopy applied in micro-structures surface analysis

    Brito, I V; Gesualdi, M R R; Muramatsu, M; Ricardo, J

    2011-01-01

    The microscopic real-time analysis of micro structured materials is of great importance in various domains of science and technology. For other hand, the holographic interferometry comprises a group of powerful optical methods for non-destructive testing in surface analysis. The holographic microscopy uses the holographic interferometric techniques to obtain quantitative intensity and phase information of the optical waves by microscopic systems. With the development of CCD cameras, computers (hardware and software), and new materials for holographic recording, these techniques can be used to replace the classical form of registration and became promising tools in surface analysis. In this work, we developed a prototype of Photorefractive and Digital Holographic Microscope for real-time analysis of micro-structured systems based on the phase-shifting real-time holographic interferometry techniques. Using this apparatus, we are made analysis of shapes and surfaces to obtain the phase maps and the 3D profiles of some samples.

  8. Computational singular perturbation analysis of super-knock in SI engines

    Jaasim, Mohammed; Tingas, Alexandros; Herná ndez Pé rez, Francisco E.; Im, Hong G.

    2018-01-01

    the deflagration front consumes the air/fuel mixture and two points located at 3 mm from the end-wall where super-knock and mild knock occur. The CSP analysis of the point at the center of the cylinder reveals weak two-stage ignition-like dynamics with a short

  9. Parallel imaging of Drosophila embryos for quantitative analysis of genetic perturbations of the Ras pathway

    Yogesh Goyal

    2017-07-01

    Full Text Available The Ras pathway patterns the poles of the Drosophila embryo by downregulating the levels and activity of a DNA-binding transcriptional repressor Capicua (Cic. We demonstrate that the spatiotemporal pattern of Cic during this signaling event can be harnessed for functional studies of mutations in the Ras pathway in human diseases. Our approach relies on a new microfluidic device that enables parallel imaging of Cic dynamics in dozens of live embryos. We found that although the pattern of Cic in early embryos is complex, it can be accurately approximated by a product of one spatial profile and one time-dependent amplitude. Analysis of these functions of space and time alone reveals the differential effects of mutations within the Ras pathway. Given the highly conserved nature of Ras-dependent control of Cic, our approach provides new opportunities for functional analysis of multiple sequence variants from developmental abnormalities and cancers.

  10. Perturbative analysis of the influence of π+π- strong interaction on the relation between A2π creation probabilities in ns-states

    Voskresenskaya, O.O.

    2002-01-01

    It is shown that the relations between probabilities of A 2π -atoms creation in ns-states, derived with neglecting of the strong interaction between pions, hold practically unchanged if the strong interaction is taken into account in the first order of the perturbation theory. The formulation of Deser equation for the energy levels shift of the hadronic atoms (HA) is given in terms of the effective range of the strong interaction and relative correction to the Coulomb wave function of HA at origin, caused by the strong interaction. (author)

  11. A Theory of the Perturbed Consumer with General Budgets

    McFadden, Daniel L; Fosgerau, Mogens

    We consider demand systems for utility-maximizing consumers facing general budget constraints whose utilities are perturbed by additive linear shifts in marginal utilities. Budgets are required to be compact but are not required to be convex. We define demand generating functions (DGF) whose...... subgradients with respect to these perturbations are convex hulls of the utility-maximizing demands. We give necessary as well as sufficient conditions for DGF to be consistent with utility maximization, and establish under quite general conditions that utility-maximizing demands are almost everywhere single......-valued and smooth in their arguments. We also give sufficient conditions for integrability of perturbed demand. Our analysis provides a foundation for applications of consumer theory to problems with nonlinear budget constraints....

  12. Supersingular quantum perturbations

    Detwiler, L.C.; Klauder, J.R.

    1975-01-01

    A perturbation potential is called supersingular whenever generally every matrix element of the perturbation in the unperturbed eigenstates is infinite. It follows that supersingular perturbations do not have conventional perturbation expansions, say for energy eigenvalues. By invoking variational arguments, we determine the asymptotic behavior of the energy eigenvalues for asymptotically small values of the coupling constant of the supersingular perturbation

  13. Cosmological perturbations in antigravity

    Oltean, Marius; Brandenberger, Robert

    2014-10-01

    We compute the evolution of cosmological perturbations in a recently proposed Weyl-symmetric theory of two scalar fields with oppositely signed conformal couplings to Einstein gravity. It is motivated from the minimal conformal extension of the standard model, such that one of these scalar fields is the Higgs while the other is a new particle, the dilaton, introduced to make the Higgs mass conformally symmetric. At the background level, the theory admits novel geodesically complete cyclic cosmological solutions characterized by a brief period of repulsive gravity, or "antigravity," during each successive transition from a big crunch to a big bang. For simplicity, we consider scalar perturbations in the absence of anisotropies, with potential set to zero and without any radiation. We show that despite the necessarily wrong-signed kinetic term of the dilaton in the full action, these perturbations are neither ghostlike nor tachyonic in the limit of strongly repulsive gravity. On this basis, we argue—pending a future analysis of vector and tensor perturbations—that, with respect to perturbative stability, the cosmological solutions of this theory are viable.

  14. Shift work and hypertension: Prevalence and analysis of disease pathways in a German car manufacturing company.

    Ohlander, Johan; Keskin, Mekail-Cem; Stork, Joachim; Radon, Katja

    2015-05-01

    Hypertension and cardiovascular disease (CVD) may share a similar pathophysiology. Despite shift workers' CVD excess risk, studies on shift work and hypertension are inconclusive. Blood pressure and shift status for 25,343 autoworkers were obtained from medical check-ups and company registers. Cross-sectional associations modeling the total effect from shift work (day shifts, shift work without nights, rotating shift work with nights, and night shifts) on hypertension were assessed. By sequential adjustments, the influence of behavioral, psychosocial, and physiological factors on the total effect was examined, with subsequent mediation and moderation analyses. Adjusted for confounders, shift work without nights (vs. day shifts) was significantly associated with hypertension (OR 1.15, 95%CI 1.02-1.30). The total effect was mediated by BMI, physical inactivity, and sleep disorders. No moderation of the total effect by behaviors was found. The association between shift work and hypertension seems mainly attributable to behavioral mechanisms. © 2015 Wiley Periodicals, Inc.

  15. Error Analysis in a Device to Test Optical Systems by Using Ronchi Test and Phase Shifting

    Cabrera-Perez, Brasilia; Castro-Ramos, Jorge; Gordiano-Alvarado, Gabriel; Vazquez y Montiel, Sergio

    2008-01-01

    In optical workshops, Ronchi test is used to determine the optical quality of any concave surface, while it is in the polishing process its quality is verified. The Ronchi test is one of the simplest and most effective methods used for evaluating and measuring aberrations. In this work, we describe a device to test converging mirrors and lenses either with small F/numbers or large F/numbers, using LED (Light-Emitting Diode) that has been adapted in the Ronchi testing as source of illumination. With LED used the radiation angle is bigger than common LED. It uses external power supplies to have well stability intensity to avoid error during the phase shift. The setup also has the advantage to receive automatic input and output data, this is possible because phase shifting interferometry and a square Ronchi ruling with a variable intensity LED were used. Error analysis of the different parameters involved in the test of Ronchi was made. For example, we analyze the error in the shifting of phase, the error introduced by the movement of the motor, misalignments of x-axis, y-axis and z-axis of the surface under test, error in the period of the grid used

  16. The Influence of Power Shifts in Data Collection and Analysis Stages: A Focus on Qualitative Research Interview

    Anyan, Frederick

    2013-01-01

    This paper analyzes the power relation between the interviewer and the interviewee in the qualitative research interview methodology. The paper sets out to grapple with the extent to which the dynamisms in power shifts influence data collection and analysis in the interview methodology. The exploration of power shifts in the qualitative research…

  17. Reduction and Analysis of Low Temperature Shift Heterogeneous Catalyst for Water Gas Reaction in Ammonia Production

    Zečević, N.

    2013-09-01

    Full Text Available In order to obtain additional quantities of hydrogen after the reforming reactions of natural gas and protect the ammonia synthesis catalyst, it is crucial to achieve and maintain maximum possible activity, selectivity and stability of the low temperature shift catalyst for conversion of water gas reaction during its lifetime. Whereas the heterogeneous catalyst comes in oxidized form, it is of the utmost importance to conduct the reduction procedure properly. The proper reduction procedure and continuous analysis of its performance would ensure the required activity, selectivity and stability throughout the catalyst’s service time. For the proper reduction procedure ofthe low temperature shift catalyst, in addition to process equipment, also necessary is a reliable and realistic system for temperature measurements, which will be effective for monitoring the exothermal temperature curves through all catalyst bed layers. For efficiency evaluation of low shift temperature catalyst reduction and its optimization, it is necessary to determine at regular time intervals the temperature approach to equilibrium and temperature profiles of individual layers by means of "S" and "die off" temperature exothermal curves. Based on the obtained data, the optimum inlet temperature could be determined, in order to maximally extend the service life of the heterogeneous catalyst as much as possible, and achieve the optimum equilibrium for conversion of the water gas. This paper presents the methodology for in situ reduction of the low temperature shift heterogeneous catalyst and the developed system for monitoring its individual layers to achieve the minimum possible content of carbon monoxide at the exit of the reactor. The developed system for temperature monitoring through heterogeneous catalyst layers provides the proper procedure for reduction and adjustment of optimum process working conditions for the catalyst by the continuous increase of reactor inlet

  18. Perturbations i have Known and Loved

    Field, Robert W.

    2011-06-01

    A spectroscopic perturbation is a disruption of a ^1Σ-^1Σ-like regular pattern that can embody level-shifts, extra lines, and intensity anomalies. Once upon a time, when a band was labeled ``perturbed,'' it was considered worthless because it could at best yield molecular constants unsuited for archival tables. Nevertheless, a few brave spectroscopists, notably Albin Lagerqvist and Richard Barrow, collected perturbations because they knew that the pattern of multiple perturbations formed an intricate puzzle that would eventually reveal the presence and electronic symmetry of otherwise unobservable electronic states. There are many kinds of patterns of broken patterns. In my PhD thesis I showed how to determine absolute vibrational assignments for the perturber from patterns among the observed values of perturbation matrix elements. When a ^3Π state is perturbed, its six (Ω, parity) components capture a pattern of level shifts and intensity anomalies that reveals more about the nature of the perturber than a simple perturbation of the single component of a ^1Σ state. In perturbation-facilitated OODR, a perturbed singlet level acts as a spectroscopic doorway through which the entire triplet manifold may be systematically explored. For polyatomic molecule vibrations, a vibrational polyad (a group of mutually perturbing vibrational levels, among which the perturbation matrix elements are expected to follow harmonic oscillator scaling rules) can contain more components than a ^3Π state and intrapolyad patterns can be exquisitely sensitive not merely to the nature of an interloper within the polyad but also to the eigenvector character of the vibronic state from which the polyad is viewed. Variation of scaled polyad interaction parameters from one polyad to the next, a pattern of patterns, can signal proximity to an isomerization barrier. Everything in Rydberg-land seems to scale as N⋆-3, yet a trespassing valence state causes all scaling and propensity rules go

  19. Film Adaptation as Translation: An Analysis of Adaptation Shifts in Silver Linings Playbook

    Katerina Perdikaki

    2017-12-01

    Full Text Available The purpose of this paper is to approach film adaptation as a modality of translation and to provide a systematic analysis of the changes occurring in the adaptation of a novel for the big screen. These changes, i.e. adaptation shifts, are examined by means of a model that consists of a descriptive/comparative component and an interpretive component. The model is derived from combining insights from adaptation and translation studies and thus builds on the interdisciplinary nature of adaptation studies so as to offer a comprehensive methodological tool for the analysis of adaptations. As processes and products, adaptation and translation involve an act of communication between a source and a target text within a new sociocultural context. In this light, adaptation can be examined as a case of intersemiotic translation in that it involves the transfer of meaning between two different media; in the case of film adaptation, more specifically, meaning is transferred from book to film and the dynamics between the source novel and adaptation is juxtaposed with that between a source text and its translation. The adaptation model is applied to the film adaptation Silver Linings Playbook with an aim to understand the aspects in which the adaptation differs from the source novel and the rationale behind the adaptation shifts. Finally, it is argued that such an analysis from a descriptive as well as an interpretive perspective can lead to a more holistic understanding of adaptation as a cultural phenomenon in the contemporary creative industries.

  20. Variance analysis of the Monte Carlo perturbation source method in inhomogeneous linear particle transport problems. Derivation of formulae

    Noack, K.

    1981-01-01

    The perturbation source method is used in the Monte Carlo method in calculating small effects in a particle field. It offers primising possibilities for introducing positive correlation between subtracting estimates even in the cases where other methods fail, in the case of geometrical variations of a given arrangement. The perturbation source method is formulated on the basis of integral equations for the particle fields. The formulae for the second moment of the difference of events are derived. Explicity a certain class of transport games and different procedures for generating the so-called perturbation particles are considered [ru

  1. Analysis of K → 3π decays in chiral perturbation theory

    Cheng Haiyang; Cheung, C.Y.; Yeung Waibong

    1989-01-01

    Using the recently proposed higher-order chiral Lagrangians determined from the integration of nontopological chiral anomalies, we calculate corrections to the current-algebra analysis of K→3π decay amplitudes expanded in powers of the Dalitz variables. Effects of quartic-derivative weak chiral Lagrangians are determined through the use of short-distance effective weak Hamiltonian and the factorization method. We find that (1) the constant and linear terms in the amplitude for ΔI=1/2 K→3π are in excellent agreement with experiment; the previous discrepancy of (20-35)% between current algebra and data is thus accounted for by the higher-order effective Lagrangians, (2) the penguin interaction does not play an essential role in the ΔI=1/2 rule, for otherwise it will lead to a large disagreement for the constant and linear terms, (3) one of the two quadratic terms in the ΔI=1/2 process, which arise from the quartic chiral Lagrangians, is in accord with data within experimental errors, while the other is off by four standard deviations, (4) the linear term in the ΔI=3/2 transitions is in good agreement with experiment and contributions from quadratic terms are sizable. (orig.)

  2. Systems analysis of multiple regulator perturbations allows discovery of virulence factors in Salmonella

    Yoon, Hyunjin; Ansong, Charles; McDermott, Jason E.; Gritsenko, Marina A.; Smith, Richard D.; Heffron, Fred; Adkins, Joshua N.

    2011-06-28

    Background: Systemic bacterial infections are highly regulated and complex processes that are orchestrated by numerous virulence factors. Genes that are coordinately controlled by the set of regulators required for systemic infection are potentially required for pathogenicity. Results: In this study we present a systems biology approach in which sample-matched multi-omic measurements of fourteen virulence-essential regulator mutants were coupled with computational network analysis to efficiently identify Salmonella virulence factors. Immunoblot experiments verified network-predicted virulence factors and a subset was determined to be secreted into the host cytoplasm, suggesting that they are virulence factors directly interacting with host cellular components. Two of these, SrfN and PagK2, were required for full mouse virulence and were shown to be translocated independent of either of the type III secretion systems in Salmonella or the type III injectisome-related flagellar mechanism. Conclusions: Integrating multi-omic datasets from Salmonella mutants lacking virulence regulators not only identified novel virulence factors but also defined a new class of translocated effectors involved in pathogenesis. The success of this strategy at discovery of known and novel virulence factors suggests that the approach may have applicability for other bacterial pathogens.

  3. Application of perturbation methods and sensitivity analysis to water hammer problems in hydraulic networks

    Balino, Jorge L.; Larreteguy, Axel E.; Andrade Lima, Fernando R.

    1995-01-01

    The differential method was applied to the sensitivity analysis for water hammer problems in hydraulic networks. Starting from the classical water hammer equations in a single-phase liquid with friction, the state vector comprising the piezometric head and the velocity was defined. Applying the differential method the adjoint operator, the adjoint equations with the general form of their boundary conditions, and the general form of the bilinear concomitant were calculated. The discretized adjoint equations and the corresponding boundary conditions were programmed and solved by using the so called method of characteristics. As an example, a constant-level tank connected through a pipe to a valve discharging to atmosphere was considered. The bilinear concomitant was calculated for this particular case. The corresponding sensitivity coefficients due to the variation of different parameters by using both the differential method and the response surface generated by the computer code WHAT were also calculated. The results obtained with these methods show excellent agreement. (author). 11 refs, 2 figs, 2 tabs

  4. Suppression of period-doubling and nonlinear parametric effects in periodically perturbed systems

    Bryant, P.; Wiesenfeld, K.

    1986-01-01

    We consider the effect on a generic period-doubling bifurcation of a periodic perturbation, whose frequency ω 1 is near the period-doubled frequency ω 0 /2. The perturbation is shown to always suppress the bifurcation, shifting the bifurcation point and stabilizing the behavior at the original bifurcation point. We derive an equation characterizing the response of the system to the perturbation, analysis of which reveals many interesting features of the perturbed bifurcation, including (1) the scaling law relating the shift of the bifurcation point and the amplitude of the perturbation, (2) the characteristics of the system's response as a function of bifurcation parameter, (3) parametric amplification of the perturbation signal including nonlinear effects such as gain saturation and a discontinuity in the response at a critical perturbation amplitude, (4) the effect of the detuning (ω 1 -ω 0 /2) on the bifurcation, and (5) the emergence of a closely spaced set of peaks in the response spectrum. An important application is the use of period-doubling systems as small-signal amplifiers, e.g., the superconducting Josephson parametric amplifier

  5. Metagenomic and metabolomic analysis of the toxic effects of trichloroacetamide-induced gut microbiome and urine metabolome perturbations in mice.

    Zhang, Yan; Zhao, Fuzheng; Deng, Yongfeng; Zhao, Yanping; Ren, Hongqiang

    2015-04-03

    Disinfection byproducts (DBPs) in drinking water have been linked to various diseases, including colon, colorectal, rectal, and bladder cancer. Trichloroacetamide (TCAcAm) is an emerging nitrogenous DBP, and our previous study found that TCAcAm could induce some changes associated with host-gut microbiota co-metabolism. In this study, we used an integrated approach combining metagenomics, based on high-throughput sequencing, and metabolomics, based on nuclear magnetic resonance (NMR), to evaluate the toxic effects of TCAcAm exposure on the gut microbiome and urine metabolome. High-throughput sequencing revealed that the gut microbiome's composition and function were significantly altered after TCAcAm exposure for 90 days in Mus musculus mice. In addition, metabolomic analysis showed that a number of gut microbiota-related metabolites were dramatically perturbed in the urine of the mice. These results may provide novel insight into evaluating the health risk of environmental pollutants as well as revealing the potential mechanism of TCAcAm's toxic effects.

  6. Application of perturbation theory to the non-linear vibration analysis of a string including the bending moment effects

    Esmaeilzadeh Khadem, S.; Rezaee, M.

    2001-01-01

    In this paper the large amplitude and non-linear vibration of a string is considered. The initial tension, lateral vibration amplitude, diameter and the modulus of elasticity of the string have main effects on its natural frequencies. Increasing the lateral vibration amplitude makes the assumption of constant initial tension invalid. In this case, therefore, it is impossible to use the classical equation of string with small amplitude transverse motion assumption. On the other hand, by increasing the string diameter, the bending moment effect will increase dramatically, and acts as an impressive restoring moment. Considering the effects of the bending moments, the nonlinear equation governing the large amplitude transverse vibration of a string is derived. The time dependent portion of the governing equation has the from of Duff ing equation is solved using the perturbation theory. The results of the analysis are shown in appropriate graphs, and the natural frequencies of the string due to the non-linear factors are compared with the natural frequencies of the linear vibration os a string without bending moment effects

  7. Large-scale evaluation of dynamically important residues in proteins predicted by the perturbation analysis of a coarse-grained elastic model

    Tekpinar Mustafa

    2009-07-01

    Full Text Available Abstract Backgrounds It is increasingly recognized that protein functions often require intricate conformational dynamics, which involves a network of key amino acid residues that couple spatially separated functional sites. Tremendous efforts have been made to identify these key residues by experimental and computational means. Results We have performed a large-scale evaluation of the predictions of dynamically important residues by a variety of computational protocols including three based on the perturbation and correlation analysis of a coarse-grained elastic model. This study is performed for two lists of test cases with >500 pairs of protein structures. The dynamically important residues predicted by the perturbation and correlation analysis are found to be strongly or moderately conserved in >67% of test cases. They form a sparse network of residues which are clustered both in 3D space and along protein sequence. Their overall conservation is attributed to their dynamic role rather than ligand binding or high network connectivity. Conclusion By modeling how the protein structural fluctuations respond to residue-position-specific perturbations, our highly efficient perturbation and correlation analysis can be used to dissect the functional conformational changes in various proteins with a residue level of detail. The predictions of dynamically important residues serve as promising targets for mutational and functional studies.

  8. Shift-invariant discrete wavelet transform analysis for retinal image classification.

    Khademi, April; Krishnan, Sridhar

    2007-12-01

    This work involves retinal image classification and a novel analysis system was developed. From the compressed domain, the proposed scheme extracts textural features from wavelet coefficients, which describe the relative homogeneity of localized areas of the retinal images. Since the discrete wavelet transform (DWT) is shift-variant, a shift-invariant DWT was explored to ensure that a robust feature set was extracted. To combat the small database size, linear discriminant analysis classification was used with the leave one out method. 38 normal and 48 abnormal (exudates, large drusens, fine drusens, choroidal neovascularization, central vein and artery occlusion, histoplasmosis, arteriosclerotic retinopathy, hemi-central retinal vein occlusion and more) were used and a specificity of 79% and sensitivity of 85.4% were achieved (the average classification rate is 82.2%). The success of the system can be accounted to the highly robust feature set which included translation, scale and semi-rotational, features. Additionally, this technique is database independent since the features were specifically tuned to the pathologies of the human eye.

  9. Instabilities in mimetic matter perturbations

    Firouzjahi, Hassan; Gorji, Mohammad Ali [School of Astronomy, Institute for Research in Fundamental Sciences (IPM), P.O. Box 19395-5531, Tehran (Iran, Islamic Republic of); Mansoori, Seyed Ali Hosseini, E-mail: firouz@ipm.ir, E-mail: gorji@ipm.ir, E-mail: shosseini@shahroodut.ac.ir, E-mail: shossein@ipm.ir [Physics Department, Shahrood University of Technology, P.O. Box 3619995161 Shahrood (Iran, Islamic Republic of)

    2017-07-01

    We study cosmological perturbations in mimetic matter scenario with a general higher derivative function. We calculate the quadratic action and show that both the kinetic term and the gradient term have the wrong sings. We perform the analysis in both comoving and Newtonian gauges and confirm that the Hamiltonians and the associated instabilities are consistent with each other in both gauges. The existence of instabilities is independent of the specific form of higher derivative function which generates gradients for mimetic field perturbations. It is verified that the ghost instability in mimetic perturbations is not associated with the higher derivative instabilities such as the Ostrogradsky ghost.

  10. [Analysis of relationship between shift-work and occupational stress among workers from different companies].

    Gu, Guizhen; Yu, Shanfa; Zhou, Wenhui; Wu, Hui

    2016-01-01

    To investigate the relationship between work in shifts and occupational stress. A total of 5338 employees from 13 companies were investigated by cluster sampling, and occupational stress measuring tools, job content questionnaire, and effort-reward imbalance questionnaire were used to investigate occupational stress factors, stress reaction, and the condition of work in shifts. The employees who worked in shifts accounted for 46.6%. The condition of work in shifts varied significantly across different companies, employees with different individual features (including sex, job title, degree of education, age, working years, smoking, and drinking), and employees with different weekly working times(Pwork in shifts(Pwork in shifts, those who worked in shifts had significantly lower scores of technology utilization, work control level, psychological need, reward, social support, and job satisfaction(PWork in shifts can affect health status, and is associated with occupational stress.

  11. Conflict Detection Performance Analysis for Function Allocation Using Time-Shifted Recorded Traffic Data

    Guerreiro, Nelson M.; Butler, Ricky W.; Maddalon, Jeffrey M.; Hagen, George E.; Lewis, Timothy A.

    2015-01-01

    The performance of the conflict detection function in a separation assurance system is dependent on the content and quality of the data available to perform that function. Specifically, data quality and data content available to the conflict detection function have a direct impact on the accuracy of the prediction of an aircraft's future state or trajectory, which, in turn, impacts the ability to successfully anticipate potential losses of separation (detect future conflicts). Consequently, other separation assurance functions that rely on the conflict detection function - namely, conflict resolution - are prone to negative performance impacts. The many possible allocations and implementations of the conflict detection function between centralized and distributed systems drive the need to understand the key relationships that impact conflict detection performance, with respect to differences in data available. This paper presents the preliminary results of an analysis technique developed to investigate the impacts of data quality and data content on conflict detection performance. Flight track data recorded from a day of the National Airspace System is time-shifted to create conflicts not present in the un-shifted data. A methodology is used to smooth and filter the recorded data to eliminate sensor fusion noise, data drop-outs and other anomalies in the data. The metrics used to characterize conflict detection performance are presented and a set of preliminary results is discussed.

  12. Self-stability analysis of MHTGRs: A shifted-ectropy based approach

    Dong Zhe

    2012-01-01

    Highlights: ► In this paper, self-stability of the MHTGR is analyzed from a physical viewpoint. ► A shifted-ectropy method for self-stability analysis of general thermodynamic systems is established. ► Then it is proved theoretically that the equilibriums of the MHTGR are globally asymptotically stable. ► Numerical verification results are consistent with the theoretical result. - Abstract: Because of the strong inherent safety, the modular high temperature gas-cooled nuclear reactor (MHTGR) has been seen as the chosen technology for the next generation of nuclear power plants (NPPs). Self-stability of a nuclear reactor, which is the ability that the reactor state can converge to an equilibrium point without control input, has great meaning in designing control and operation strategies for the NPPs based on MHTGR technology. In this paper, self-stability of the MHTGR is analyzed from a physical viewpoint. A shifted-ectropy method for analyzing the stability of the equilibriums of general thermodynamic systems is firstly established. Based upon this approach, it is proved theoretically that the equilibriums of the MHTGR dynamics are globally asymptotically stable. Numerical simulation results, which illustrate the MHTGR self-stability feature directly, are consistent with the theoretical result.

  13. Stress Analysis of an Edge-Cracked Plate by using Photoelastic Fringe Phase Shifting Method

    Baek, Tae Hyun; Kim, Myung Soo; Cho, Sung Ho

    2000-01-01

    The method of photoelasticity allows one to obtain principal stress differences and principal stress directions in a photoelastic model. In the classical approach, the photoelastic parameters are measured manually point by point. The previous methods require much time and skill in the identification and measurement of photoelastic data. Fringe phase shifting method has been recently developed and widely used to measure and analyze fringe data in photo-mechanics. This paper presents the test results of photoelastic fringe phase shifting technique for the stress analysis of a circular disk under compression and an edge-cracked plate subjected to tensile load. The technique used here requires four phase stepped photoelastic images obtained from a circular polariscope by rotating the analyzer at 0 .deg. ,45 .deg. ,90 .deg. ,and 135 .deg. . Experimental results are compared with those or FEM. Good agreement between the results can be observed. However, some error may be included if the technique is used to general direction which is not parallel to isoclinic fringe

  14. Genomic analysis reveals a potential role for cell cycle perturbation in HCV-mediated apoptosis of cultured hepatocytes.

    Kathie-Anne Walters

    2009-01-01

    Full Text Available The mechanisms of liver injury associated with chronic HCV infection, as well as the individual roles of both viral and host factors, are not clearly defined. However, it is becoming increasingly clear that direct cytopathic effects, in addition to immune-mediated processes, play an important role in liver injury. Gene expression profiling during multiple time-points of acute HCV infection of cultured Huh-7.5 cells was performed to gain insight into the cellular mechanism of HCV-associated cytopathic effect. Maximal induction of cell-death-related genes and appearance of activated caspase-3 in HCV-infected cells coincided with peak viral replication, suggesting a link between viral load and apoptosis. Gene ontology analysis revealed that many of the cell-death genes function to induce apoptosis in response to cell cycle arrest. Labeling of dividing cells in culture followed by flow cytometry also demonstrated the presence of significantly fewer cells in S-phase in HCV-infected relative to mock cultures, suggesting HCV infection is associated with delayed cell cycle progression. Regulation of numerous genes involved in anti-oxidative stress response and TGF-beta1 signaling suggest these as possible causes of delayed cell cycle progression. Significantly, a subset of cell-death genes regulated during in vitro HCV infection was similarly regulated specifically in liver tissue from a cohort of HCV-infected liver transplant patients with rapidly progressive fibrosis. Collectively, these data suggest that HCV mediates direct cytopathic effects through deregulation of the cell cycle and that this process may contribute to liver disease progression. This in vitro system could be utilized to further define the cellular mechanism of this perturbation.

  15. Analysis of Weyl-affine theories of gravity in terms of the gravitational frequency shift effect

    Coley, A.A.; Sarmiento, G.A.

    1986-01-01

    A subclass of nonmetric theories of gravity, called Weyl-affine theories of gravity (WATGs), is analyzed by calculating their predictions for the gravitational frequency shift undergone by a wave signal in a planned solar probe. The analysis is carried out using a formalism in a spherically symmetric and static gravitational field. One of the advantages of the formalism is that any possible ''nonmetricity'' is contained in an arbitrary function, λ, of the Newtonian gravitational potential, U. The numerical results are calculated for a situation modeling a future experiment in the solar system. In the calculations, the metric components and the function, λ, are expanded up to third order in U. Within the limits of the gravitational redshift experiments performed to date, it is found that WATGs must coincide with their metric counterparts (i.e., λ is unity). It is hoped that the planned solar probe will test the nature of the theories under investigation to a higher degree of accuracy

  16. Dynamic analysis of large structures with uncertain parameters based on coupling component mode synthesis and perturbation method

    D. Sarsri

    2016-03-01

    Full Text Available This paper presents a methodological approach to compute the stochastic eigenmodes of large FE models with parameter uncertainties based on coupling of second order perturbation method and component mode synthesis methods. Various component mode synthesis methods are used to optimally reduce the size of the model. The statistical first two moments of dynamic response of the reduced system are obtained by the second order perturbation method. Numerical results illustrating the accuracy and efficiency of the proposed coupled methodological procedures for large FE models with uncertain parameters are presented.

  17. Increased precision for analysis of protein-ligand dissociation constants determined from chemical shift titrations

    Markin, Craig J.; Spyracopoulos, Leo, E-mail: leo.spyracopoulos@ualberta.ca [University of Alberta, Department of Biochemistry (Canada)

    2012-06-15

    NMR is ideally suited for the analysis of protein-protein and protein ligand interactions with dissociation constants ranging from {approx}2 {mu}M to {approx}1 mM, and with kinetics in the fast exchange regime on the NMR timescale. For the determination of dissociation constants (K{sub D}) of 1:1 protein-protein or protein-ligand interactions using NMR, the protein and ligand concentrations must necessarily be similar in magnitude to the K{sub D}, and nonlinear least squares analysis of chemical shift changes as a function of ligand concentration is employed to determine estimates for the parameters K{sub D} and the maximum chemical shift change ({Delta}{delta}{sub max}). During a typical NMR titration, the initial protein concentration, [P{sub 0}], is held nearly constant. For this condition, to determine the most accurate parameters for K{sub D} and {Delta}{delta}{sub max} from nonlinear least squares analyses requires initial protein concentrations that are {approx}0.5 Multiplication-Sign K{sub D}, and a maximum concentration for the ligand, or titrant, of {approx}10 Multiplication-Sign [P{sub 0}]. From a practical standpoint, these requirements are often difficult to achieve. Using Monte Carlo simulations, we demonstrate that co-variation of the ligand and protein concentrations during a titration leads to an increase in the precision of the fitted K{sub D} and {Delta}{delta}{sub max} values when [P{sub 0}] > K{sub D}. Importantly, judicious choice of protein and ligand concentrations for a given NMR titration, combined with nonlinear least squares analyses using two independent variables (ligand and protein concentrations) and two parameters (K{sub D} and {Delta}{delta}{sub max}) is a straightforward approach to increasing the accuracy of measured dissociation constants for 1:1 protein-ligand interactions.

  18. Orthopedic resident work-shift analysis: are we making the best use of resident work hours?

    Hamid, Kamran S; Nwachukwu, Benedict U; Hsu, Eugene; Edgerton, Colston A; Hobson, David R; Lang, Jason E

    2014-01-01

    Surgery programs have been tasked to meet rising demands in patient surgical care while simultaneously providing adequate resident training in the midst of increasing resident work-hour restrictions. The purpose of this study was to quantify orthopedic surgery resident workflow and identify areas needing improved resident efficiency. We hypothesize that residents spend a disproportionate amount of time involved in activities that do not relate directly to patient care or maximize resident education. We observed 4 orthopedic surgery residents on the orthopedic consult service at a major tertiary care center for 72 consecutive hours (6 consecutive shifts). We collected minute-by-minute data using predefined work-task criteria: direct new patient contact, direct existing patient contact, communications with other providers, documentation/administrative time, transit time, and basic human needs. A seventh category comprised remaining less-productive work was termed as standby. In a 720-minute shift, residents spent on an average: 191 minutes (26.5%) performing documentation/administrative duties, 167.0 minutes (23.2%) in direct contact with new patient consults, 129.6 minutes (17.1%) in communication with other providers regarding patients, 116.2 (16.1%) minutes in standby, 63.7 minutes (8.8%) in transit, 32.6 minutes (4.5%) with existing patients, and 20 minutes (2.7%) attending to basic human needs. Residents performed an additional 130 minutes of administrative work off duty. Secondary analysis revealed residents were more likely to perform administrative work rather than directly interact with existing patients (p = 0.006) or attend to basic human needs (p = 0.003). Orthopedic surgery residents spend a large proportion of their time performing documentation/administrative-type work and their workday can be operationally optimized to minimize nonvalue-adding tasks. Formal workflow analysis may aid program directors in systematic process improvements to better align

  19. Quantitative analysis of deuterium using the isotopic effect on quaternary {sup 13}C NMR chemical shifts

    Darwish, Tamim A., E-mail: tamim.darwish@ansto.gov.au [National Deuteration Facility, Australian Nuclear Science and Technology Organisation, Locked Bag 21, Kirrawee DC, NSW 2232 (Australia); Yepuri, Nageshwar Rao; Holden, Peter J. [National Deuteration Facility, Australian Nuclear Science and Technology Organisation, Locked Bag 21, Kirrawee DC, NSW 2232 (Australia); James, Michael [Australian Synchrotron, 800 Blackburn Road, Clayton, Victoria 3168 (Australia)

    2016-07-13

    Quantitative analysis of specifically deuterated compounds can be achieved by a number of conventional methods, such as mass spectroscopy, or by quantifying the residual {sup 1}H NMR signals compared to signals from internal standards. However, site specific quantification using these methods becomes challenging when dealing with non-specifically or randomly deuterated compounds that are produced by metal catalyzed hydrothermal reactions in D{sub 2}O, one of the most convenient deuteration methods. In this study, deuterium-induced NMR isotope shifts of quaternary {sup 13}C resonances neighboring deuterated sites have been utilized to quantify the degree of isotope labeling of molecular sites in non-specifically deuterated molecules. By probing {sup 13}C NMR signals while decoupling both proton and deuterium nuclei, it is possible to resolve {sup 13}C resonances of the different isotopologues based on the isotopic shifts and the degree of deuteration of the carbon atoms. We demonstrate that in different isotopologues, the same quaternary carbon, neighboring partially deuterated carbon atoms, are affected to an equal extent by relaxation. Decoupling both nuclei ({sup 1}H, {sup 2}H) resolves closely separated quaternary {sup 13}C signals of the different isotopologues, and allows their accurate integration and quantification under short relaxation delays (D1 = 1 s) and hence fast accumulative spectral acquisition. We have performed a number of approaches to quantify the deuterium content at different specific sites to demonstrate a convenient and generic analysis method for use in randomly deuterated molecules, or in cases of specifically deuterated molecules where back-exchange processes may take place during work up. - Graphical abstract: The relative intensities of quaternary {sup 13}C {"1H,"2H} resonances are equal despite the different relaxation delays, allowing the relative abundance of the different deuterated isotopologues to be calculated using NMR fast

  20. A meta-analysis including dose-response relationship between night shift work and the risk of colorectal cancer

    Wang, Xiao; Ji, Alin; Zhu, Yi; Liang, Zhen; Wu, Jian; Li, Shiqi; Meng, Shuai; Zheng, Xiangyi; Xie, Liping

    2015-01-01

    A meta-analysis was conducted to quantitatively evaluate the correlation between night shift work and the risk of colorectal cancer. We searched for publications up to March 2015 using PubMed, Web of Science, Cochrane Library, EMBASE and the Chinese National Knowledge Infrastructure databases, and the references of the retrieved articles and relevant reviews were also checked. OR and 95% CI were used to assess the degree of the correlation between night shift work and risk of colorectal cance...

  1. Night Shift Work and Breast Cancer Incidence: Three Prospective Studies and Meta-analysis of Published Studies.

    Travis, Ruth C; Balkwill, Angela; Fensom, Georgina K; Appleby, Paul N; Reeves, Gillian K; Wang, Xiao-Si; Roddam, Andrew W; Gathani, Toral; Peto, Richard; Green, Jane; Key, Timothy J; Beral, Valerie

    2016-12-01

    It has been proposed that night shift work could increase breast cancer incidence. A 2007 World Health Organization review concluded, mainly from animal evidence, that shift work involving circadian disruption is probably carcinogenic to humans. We therefore aimed to generate prospective epidemiological evidence on night shift work and breast cancer incidence. Overall, 522 246 Million Women Study, 22 559 EPIC-Oxford, and 251 045 UK Biobank participants answered questions on shift work and were followed for incident cancer. Cox regression yielded multivariable-adjusted breast cancer incidence rate ratios (RRs) and 95% confidence intervals (CIs) for night shift work vs no night shift work, and likelihood ratio tests for interaction were used to assess heterogeneity. Our meta-analyses combined these and relative risks from the seven previously published prospective studies (1.4 million women in total), using inverse-variance weighted averages of the study-specific log RRs. In the Million Women Study, EPIC-Oxford, and UK Biobank, respectively, 673, 28, and 67 women who reported night shift work developed breast cancer, and the RRs for any vs no night shift work were 1.00 (95% CI = 0.92 to 1.08), 1.07 (95% CI = 0.71 to 1.62), and 0.78 (95% CI = 0.61 to 1.00). In the Million Women Study, the RR for 20 or more years of night shift work was 1.00 (95% CI = 0.81 to 1.23), with no statistically significant heterogeneity by sleep patterns or breast cancer risk factors. Our meta-analysis of all 10 prospective studies included 4660 breast cancers in women reporting night shift work; compared with other women, the combined relative risks were 0.99 (95% CI = 0.95 to 1.03) for any night shift work, 1.01 (95% CI = 0.93 to 1.10) for 20 or more years of night shift work, and 1.00 (95% CI = 0.87 to 1.14) for 30 or more years. The totality of the prospective evidence shows that night shift work, including long-term shift work, has little or no effect on

  2. Deep sequencing analysis of HBV genotype shift and correlation with antiviral efficiency during adefovir dipivoxil therapy.

    Yuwei Wang

    Full Text Available Viral genotype shift in chronic hepatitis B (CHB patients during antiviral therapy has been reported, but the underlying mechanism remains elusive.38 CHB patients treated with ADV for one year were selected for studying genotype shift by both deep sequencing and Sanger sequencing method.Sanger sequencing method found that 7.9% patients showed mixed genotype before ADV therapy. In contrast, all 38 patients showed mixed genotype before ADV treatment by deep sequencing. 95.5% mixed genotype rate was also obtained from additional 200 treatment-naïve CHB patients. Of the 13 patients with genotype shift, the fraction of the minor genotype in 5 patients (38% increased gradually during the course of ADV treatment. Furthermore, responses to ADV and HBeAg seroconversion were associated with the high rate of genotype shift, suggesting drug and immune pressure may be key factors to induce genotype shift. Interestingly, patients with genotype C had a significantly higher rate of genotype shift than genotype B. In genotype shift group, ADV treatment induced a marked enhancement of genotype B ratio accompanied by a reduction of genotype C ratio, suggesting genotype C may be more sensitive to ADV than genotype B. Moreover, patients with dominant genotype C may have a better therapeutic effect. Finally, genotype shifts was correlated with clinical improvement in terms of ALT.Our findings provided a rational explanation for genotype shift among ADV-treated CHB patients. The genotype and genotype shift might be associated with antiviral efficiency.

  3. Large-order perturbation theory

    Wu, T.T.

    1982-01-01

    The original motivation for studying the asymptotic behavior of the coefficients of perturbation series came from quantum field theory. An overview is given of some of the attempts to understand quantum field theory beyond finite-order perturbation series. At least is the case of the Thirring model and probably in general, the full content of a relativistic quantum field theory cannot be recovered from its perturbation series. This difficulty, however, does not occur in quantum mechanics, and the anharmonic oscillator is used to illustrate the methods used in large-order perturbation theory. Two completely different methods are discussed, the first one using the WKB approximation, and a second one involving the statistical analysis of Feynman diagrams. The first one is well developed and gives detailed information about the desired asymptotic behavior, while the second one is still in its infancy and gives instead information about the distribution of vertices of the Feynman diagrams

  4. New evidence and impact of electron transport non-linearities based on new perturbative inter-modulation analysis

    van Berkel, M.; Kobayashi, T.; Igami, H.; Vandersteen, Gerd; Hogeweij, G.M.D.; Tanaka, K.; Tamura, N.; Zwart, Hans; Kubo, S.; Ito, S.; Tsuchiya, H.; de Baar, M.R.

    2017-01-01

    A new methodology to analyze non-linear components in perturbative transport experiments is introduced. The methodology has been experimentally validated in the Large Helical Device for the electron heat transport channel. Electron cyclotron resonance heating with different modulation frequencies by

  5. DEPTH-CHARGE static and time-dependent perturbation/sensitivity system for nuclear reactor core analysis. Revision I

    White, J.R.

    1985-04-01

    This report provides the background theory, user input, and sample problems required for the efficient application of the DEPTH-CHARGE system - a code black for both static and time-dependent perturbation theory and data sensitivity analyses. The DEPTH-CHARGE system is of modular construction and has been implemented within the VENTURE-BURNER computational system at Oak Ridge National Laboratory. The DEPTH module (coupled with VENTURE) solves for the three adjoint functions of Depletion Perturbation Theory and calculates the desired time-dependent derivatives of the response with respect to the nuclide concentrations and nuclear data utilized in the reference model. The CHARGE code is a collection of utility routines for general data manipulation and input preparation and considerably extends the usefulness of the system through the automatic generation of adjoint sources, estimated perturbed responses, and relative data sensitivity coefficients. Combined, the DEPTH-CHARGE system provides, for the first time, a complete generalized first-order perturbation/sensitivity theory capability for both static and time-dependent analyses of realistic multidimensional reactor models. This current documentation incorporates minor revisions to the original DEPTH-CHARGE documentation (ORNL/CSD-78) to reflect some new capabilities within the individual codes

  6. Buckling collapse analysis of framed structures by using adaptively shifted integration technique. Junnogata shifted intergration ho ni yoru honegumi kozo no zakutsu hokai kaiseki

    Toi, Y.; Isobe, D. (The University of Tokyo, Tokyo (Japan). Institute of Industrial Science)

    1993-09-01

    This paper describes the following matters on application of an adaptively shifted integration technique to a buckling collapse analysis of framed structures: This method is a method in a finite element analysis using three-dimensional girder elements to arrange value integration points at optimal locations in a linear analysis if the elements are in an elastic transform condition on the whole. The method then moves the value integration points so that plastic hinge will occur in these locations immediately after part of the elements has yielded. The method was applied to analyzing an elastic buckling problem in several loading patterns for either a both-end supported or a one-end fixed beam member. A result was obtained that a number of elements required for one member is four at minimum. In a buckling analysis of framed structures, a satisfactory result was obtained by using an automatic element segmenting algorithm, which begins the analysis with one element one member, and immediately after a member is determined with a possibility of generation of buckling, splits that member only into four elements. 6 refs., 5 figs.

  7. Shifts in metabolic hydrogen sinks in the methanogenesis-inhibited ruminal fermentation: a meta-analysis

    Emilio M. Ungerfeld

    2015-02-01

    Full Text Available Maximizing the flow of metabolic hydrogen ([H] in the rumen away from CH4 and towards volatile fatty acids (VFA would increase the efficiency of ruminant production and decrease its environmental impact. The objectives of this meta-analysis were: i To quantify shifts in metabolic hydrogen sinks when inhibiting ruminal methanogenesis in vitro; and ii To understand the variation in shifts of metabolic hydrogen sinks among experiments and between batch and continuous cultures systems when methanogenesis is inhibited. Batch (28 experiments, N=193 and continuous (16 experiments, N=79 culture databases of experiments with at least 50% inhibition in CH4 production were compiled. Inhibiting methanogenesis generally resulted in less fermentation and digestion in most batch culture, but not in most continuous culture, experiments. Inhibiting CH4 production in batch cultures resulted in redirection of metabolic hydrogen towards propionate and H2 but not butyrate. In continuous cultures, there was no overall metabolic hydrogen redirection towards propionate or butyrate, and H2 as a proportion of metabolic hydrogen spared from CH4 production was numerically smaller compared to batch cultures. Dihydrogen accumulation was affected by type of substrate and methanogenesis inhibitor, with highly fermentable substrates resulting in greater redirection of metabolic hydrogen towards H2 when inhibiting methanogenesis, and some oils causing small or no H2 accumulation. In both batch and continuous culture, there was a decrease in metabolic hydrogen recovered as the sum of propionate, butyrate, CH4 and H2 when inhibiting methanogenesis, and it is speculated that as CH4 production decreases metabolic hydrogen could be increasingly incorporated into formate, microbial biomass, and, perhaps, reductive acetogenesis in continuous cultures. Energetic benefits of inhibiting methanogenesis depended on the inhibitor and its concentration and on the in vitro system.

  8. Hunting down frame shifts: Ecological analysis of diverse functional gene sequences

    Michal eStrejcek

    2015-11-01

    Full Text Available Functional gene ecological analyses using amplicon sequencing can be challenging as translated sequences are often burdened with shifted reading frames. The aim of this work was to evaluate several bioinformatics tools designed to correct errors which arise during sequencing in an effort to reduce the number of frame-shifts (FS. Genes encoding for alpha subunits of biphenyl (bphA and benzoate (benA dioxygenases were used as model sequences. FrameBot, a FS correction tool, was able to reduce the number of detected FS to zero. However, up to 43.1% of sequences were discarded by FrameBot as non-specific targets. Therefore, we proposed a de novo mode of FrameBot for FS correction, which works on a similar basis as common chimera identifying platforms and is not dependent on reference sequences. By nature of FrameBot de novo design, it is crucial to provide it with data as error free as possible. We tested the ability of several publicly available correction tools to decrease the number of errors in the data sets. The combination of Maximum Expected Error (MEE filtering and single linkage pre-clustering (SLP proved the most efficient read procession. Applying FrameBot de novo on the processed data enabled analysis of BphA sequences with minimal losses of potentially functional sequences not homologous to those previously known. This experiment also demonstrated the extensive diversity of dioxygenases in soil. A script which performs FrameBot de novo is presented in the supplementary material to the study and the tool was implemented into FunGene Pipeline available at http://fungene.cme.msu.edu/FunGenePipeline/ and https://github.com/rdpstaff/Framebot.

  9. Shift Colors

    Publications & News Shift Colors Pages default Sign In NPC Logo Banner : Shift Colors Search Navy Personnel Command > Reference Library > Publications & News > Shift Colors Top Link Bar Navy Personnel Library Expand Reference Library Quick Launch Shift Colors Shift Colors Archives Mailing Address How to

  10. Infrared speckle observations of the binary Ross 614 AB - combined shift-and-add and zero-and-add analysis

    Davey, B.L.K.; Bates, R.H.T.; Cocke, W.J.; Mccarthy, D.W. Jr.; Christou, J.C.

    1989-01-01

    One-dimensional infrared speckle scans of Ross 614 AB were recorded at a wavelength of 2.2 microns, and the three bins corresponding to the three best seeing conditions were further processed by applying a shift-and-add algorithm to the set of images contained within each bin, generating three shift-and-add images with differing shift-and-add point-spread functions. A zero-and-add technique was used to deconvolve the three shift-and-add images in order to obtain parameters corresponding to the separation and the brightness ratio of a two-component model of Ross 614 Ab. Least-squares analysis results reveal a separation of 1.04 arcsec and a brightness ratio of 4.3 for the binary system at this wavelength. 31 refs

  11. A shift from significance test to hypothesis test through power analysis in medical research.

    Singh, G

    2006-01-01

    Medical research literature until recently, exhibited substantial dominance of the Fisher's significance test approach of statistical inference concentrating more on probability of type I error over Neyman-Pearson's hypothesis test considering both probability of type I and II error. Fisher's approach dichotomises results into significant or not significant results with a P value. The Neyman-Pearson's approach talks of acceptance or rejection of null hypothesis. Based on the same theory these two approaches deal with same objective and conclude in their own way. The advancement in computing techniques and availability of statistical software have resulted in increasing application of power calculations in medical research and thereby reporting the result of significance tests in the light of power of the test also. Significance test approach, when it incorporates power analysis contains the essence of hypothesis test approach. It may be safely argued that rising application of power analysis in medical research may have initiated a shift from Fisher's significance test to Neyman-Pearson's hypothesis test procedure.

  12. A shift from significance test to hypothesis test through power analysis in medical research

    Singh Girish

    2006-01-01

    Full Text Available Medical research literature until recently, exhibited substantial dominance of the Fisher′s significance test approach of statistical inference concentrating more on probability of type I error over Neyman-Pearson′s hypothesis test considering both probability of type I and II error. Fisher′s approach dichotomises results into significant or not significant results with a P value. The Neyman-Pearson′s approach talks of acceptance or rejection of null hypothesis. Based on the same theory these two approaches deal with same objective and conclude in their own way. The advancement in computing techniques and availability of statistical software have resulted in increasing application of power calculations in medical research and thereby reporting the result of significance tests in the light of power of the test also. Significance test approach, when it incorporates power analysis contains the essence of hypothesis test approach. It may be safely argued that rising application of power analysis in medical research may have initiated a shift from Fisher′s significance test to Neyman-Pearson′s hypothesis test procedure.

  13. A meta-analysis including dose-response relationship between night shift work and the risk of colorectal cancer.

    Wang, Xiao; Ji, Alin; Zhu, Yi; Liang, Zhen; Wu, Jian; Li, Shiqi; Meng, Shuai; Zheng, Xiangyi; Xie, Liping

    2015-09-22

    A meta-analysis was conducted to quantitatively evaluate the correlation between night shift work and the risk of colorectal cancer. We searched for publications up to March 2015 using PubMed, Web of Science, Cochrane Library, EMBASE and the Chinese National Knowledge Infrastructure databases, and the references of the retrieved articles and relevant reviews were also checked. OR and 95% CI were used to assess the degree of the correlation between night shift work and risk of colorectal cancer via fixed- or random-effect models. A dose-response meta-analysis was performed as well. The pooled OR estimates of the included studies illustrated that night shift work was correlated with an increased risk of colorectal cancer (OR = 1.318, 95% CI 1.121-1.551). No evidence of publication bias was detected. In the dose-response analysis, the rate of colorectal cancer increased by 11% for every 5 years increased in night shift work (OR = 1.11, 95% CI 1.03-1.20). In conclusion, this meta-analysis indicated that night shift work was associated with an increased risk of colorectal cancer. Further researches should be conducted to confirm our findings and clarify the potential biological mechanisms.

  14. Determination of the knight shift in liquid alloys of silver with lanthanides by stroboscopic observation of perturbed angular correlations according to the reaction 109Ag(p,n)109Cd

    Gundelfinger, F.

    1975-01-01

    In liquid alloys of the composition Agsub(1-x)Rsub(x) (0 109 Ag(p,n) 109 Cd* induced by 10 MeV protons. In first appoximation, the values found for the relative change of knight shift prove to be proportional to the negative z-component of the 4f-shell spin of the respective lanthanide metals. The major part of the knight shift is produced by the spin polarization of the conduction electrons due to coupling to the spins of the lanthanide ions. The possible coupling mechanisms are discussed. (orig./GSC) [de

  15. Work zone simulator analysis : driver performance and acceptance of Missouri alternate lane shift configurations.

    2017-01-13

    The objective of this project is to evaluate MoDOTs alternate lane shift sign configuration for work zones. The single sign proposed by MoDOT provides the traveler with enough information to let them know that all lanes are available to shift arou...

  16. Response analysis of a laminar premixed M-flame to flow perturbations using a linearized compressible Navier-Stokes solver

    Blanchard, M.; Schuller, T.; Sipp, D.; Schmid, P. J.

    2015-01-01

    The response of a laminar premixed methane-air flame subjected to flow perturbations around a steady state is examined experimentally and using a linearized compressible Navier-Stokes solver with a one-step chemistry mechanism to describe combustion. The unperturbed flame takes an M-shape stabilized both by a central bluff body and by the external rim of a cylindrical nozzle. This base flow is computed by a nonlinear direct simulation of the steady reacting flow, and the flame topology is shown to qualitatively correspond to experiments conducted under comparable conditions. The flame is then subjected to acoustic disturbances produced at different locations in the numerical domain, and its response is examined using the linearized solver. This linear numerical model then allows the componentwise investigation of the effects of flow disturbances on unsteady combustion and the feedback from the flame on the unsteady flow field. It is shown that a wrinkled reaction layer produces hydrodynamic disturbances in the fresh reactant flow field that superimpose on the acoustic field. This phenomenon, observed in several experiments, is fully interpreted here. The additional perturbations convected by the mean flow stem from the feedback of the perturbed flame sheet dynamics onto the flow field by a mechanism similar to that of a perturbed vortex sheet. The different regimes where this mechanism prevails are investigated by examining the phase and group velocities of flow disturbances along an axis oriented along the main direction of the flow in the fresh reactant flow field. It is shown that this mechanism dominates the low-frequency response of the wrinkled shape taken by the flame and, in particular, that it fully determines the dynamics of the flame tip from where the bulk of noise is radiated

  17. Attempt of analysis of the elastic scattering of 44 MeV alpha particles using a phase shift parameterization

    Papiau, Anne-Marie

    1966-01-01

    In order to ease the resolution of the problem of interaction of an alpha particle with a nucleus, and determine simpler hypotheses which enable the analysis of experimental results, this research thesis reports the use of a parameterization of phase shifts to reduce ambiguities and the number of parameters. After general remarks, a description of the Hamiltonian and a formulation of phase shifts, the author presents experimental data and the analytical method. Analysis is then performed for two-, three-, four- or five-parameter formulations. Efficient cross sections are then studied

  18. Developments in perturbation theory

    Greenspan, E.

    1976-01-01

    Included are sections dealing with perturbation expressions for reactivity, methods for the calculation of perturbed fluxes, integral transport theory formulations for reactivity, generalized perturbation theory, sensitivity and optimization studies, multigroup calculations of bilinear functionals, and solution of inhomogeneous Boltzmann equations with singular operators

  19. The shift to rapid job placement for people living with mental illness: an analysis of consequences.

    Gewurtz, Rebecca E; Cott, Cheryl; Rush, Brian; Kirsh, Bonnie

    2012-12-01

    This article reports on the consequences of the revised policy for employment supports within the Ontario Disability Support Program, a disability benefit program administered by the provincial government in Ontario, Canada. The revised policy involves a change from a fee-for-service model to an outcome-based funding model. This revision has encouraged a shift from preemployment to job placement services, with a particular focus on rapid placement into available jobs. Using a qualitative case study approach, 25 key informant interviews were conducted with individuals involved in developing or implementing the policy, or delivering employment services for individuals living with mental illness under the policy. Policy documents were also reviewed in order to explore the intent of the policy. Analysis focused on exploring how the policy has been implemented in practice, and its impact on employment services for individuals living with mental illness. The findings highlight how employment support practices have evolved under the new policy. Although there is now an increased focus on employment rather than preemployment supports, the financial imperative to place individuals into jobs as quickly as possible has decreased attention to career development. Jobs are reported to be concentrated at the entry-level with low pay and little security or benefits. These findings raise questions about the quality of employment being achieved under the new policy, highlight problems with adopting selected components of evidence-based approaches, and begin to explicate the influence that funding structures can have on practice.

  20. [Investigation and Analysis on shift work female workers' and the impact on reproductive health].

    Yu, C Y; Yu, W L; Xu, M; Xing, Z L

    2018-02-20

    Objective: To investigate the distribution of shift work of female workers in different industries and the relationship between shift work and reproductive health, then provide reference for the female workers' labor protection. Methods: From June to September 2016, cluster sampling questionnaire survey was performed among female workers from 11 industries including electronics, medicine and health, pharmacy. To investigate the general information, shift - work information, reproductive health and childbearing history of these female workers. Results: A total of 63 711 usable questionnaires were collected, resulting in a response rate of 96.94%.A total of 13 546 workers worked in shifts, accounting for 21.26%, the highest proportion was in the medical industry 30.61%, metallurgy 30.81%, petrochemical engineerin 26.78% respectively. Compared with the workers who did not work in shifts, those who worked in shifts had significantly higher rate of abnormal menstruation, rate of reproductive system infection in married workers, the rate of infertility (χ(2)=19.108、10.673、21.510, P <0.05) ; Compared with the workers who did not work in nightshifts, those who worked in nightshifts had significantly higher rate of abnormal menstruation, rate of reproductive system infection among married workers and rate of infertility (χ(2)=140.043、71.901、29.024, P <0.01) . Conclusion: The highest rate of shift work was in the medical industry, metallurgy, petrochemical engineering industry. Workers who worked in shifts have serious reproductive health issues, the occurrence of abnormal menstruation, reproductive system infection and infertility may associated with shift work.

  1. Error analysis of the phase-shifting technique when applied to shadow moire

    Han, Changwoon; Han Bongtae

    2006-01-01

    An exact solution for the intensity distribution of shadow moire fringes produced by a broad spectrum light is presented. A mathematical study quantifies errors in fractional fringe orders determined by the phase-shifting technique, and its validity is corroborated experimentally. The errors vary cyclically as the distance between the reference grating and the specimen increases. The amplitude of the maximum error is approximately 0.017 fringe, which defines the theoretical limit of resolution enhancement offered by the phase-shifting technique

  2. Analysis of perturbation methods for rearrangement collisions: Comparison of distorted-wave and coupled-channel-wave transition amplitudes

    Suck Salk, S.H.

    1985-01-01

    With the use of projection operators, the formal expressions of distorted-wave and coupled-channel-wave transition amplitudes for rearrangement collisions are derived. Use of projection operators (for the transition amplitudes) sharpens our understanding of the structural differences between the two transition amplitudes. The merit of each representation of the transition amplitudes is discussed. Derived perturbation potentials are found to have different structures. The rigorously derived distorted-wave Born-approximation (DWBA) transition amplitude is shown to be a generalization of the earlier DWBA expression obtained from the assumption of the dominance of elastic scattering in rearrangement collisions

  3. A meta-analysis on dose-response relationship between night shift work and the risk of breast cancer.

    Wang, F; Yeung, K L; Chan, W C; Kwok, C C H; Leung, S L; Wu, C; Chan, E Y Y; Yu, I T S; Yang, X R; Tse, L A

    2013-11-01

    This study aimed to conduct a systematic review to sum up evidence of the associations between different aspects of night shift work and female breast cancer using a dose-response meta-analysis approach. We systematicly searched all cohort and case-control studies published in English on MEDLINE, Embase, PSYCInfo, APC Journal Club and Global Health, from January 1971 to May 2013. We extracted effect measures (relative risk, RR; odd ratio, OR; or hazard ratio, HR) from individual studies to generate pooled results using meta-analysis approaches. A log-linear dose-response regression model was used to evaluate the relationship between various indicators of exposure to night shift work and breast cancer risk. Downs and Black scale was applied to assess the methodological quality of included studies. Ten studies were included in the meta-analysis. A pooled adjusted relative risk for the association between 'ever exposed to night shift work' and breast cancer was 1.19 [95% confidence interval (CI) 1.05-1.35]. Further meta-analyses on dose-response relationship showed that every 5-year increase of exposure to night shift work would correspondingly enhance the risk of breast cancer of the female by 3% (pooled RR = 1.03, 95% CI 1.01-1.05; Pheterogeneity night shifts would result in a 13% (RR = 1.13, 95% CI 1.07-1.21; Pheterogeneity = 0.06) increase in breast cancer risk. This systematic review updated the evidence that a positive dose-response relationship is likely to present for breast cancer with increasing years of employment and cumulative shifts involved in the work.

  4. Ionospheric perturbations due to earthquakes as determined from VLF and GPS-TEC data analysis at Agra, India

    Singh, Dhananjali; Singh, Birbal; Pundhir, Devbrat

    2018-04-01

    Employing SoftPAL receiver, amplitude variations of VLF transmitter signals NWC (19.8 kHz) and NPM (21.4 kHz) are analyzed at Agra station in India (Geograph. lat. 27.2°N, long. 78°E) ±15 days from five major earthquakes of magnitude M = 6.9-8.5 occurred in Indian subcontinent during the years 2011-2013. We apply nighttime fluctuation (NF) method and show that in almost all cases the trend decreases and dispersion and NF increase on the same days corresponding to each earthquake about 11-15 days prior to the main shock. Assuming that the ionospheric perturbations are caused by atmospheric gravity waves (AGW), we also calculate AGW modulation index for each case and find its values increased on the days amplitude fluctuations take place. Its value is decreased in one case only where the perturbations may be attributed to penetration of seismogenic electric field. In order to support the above results we also present GPS-TEC data analyzed by us corresponding to three of the above earthquakes. We study the TEC anomalies (unusual enhancements) and find that in one case the precursory period is almost the same as that found in NF method.

  5. Phase-shift-analysis approach to elastic neutron scattering from /sup 12/C between 9 and 12 MeV

    Tornow, W. (Tuebingen Univ. (Germany, F.R.). Physikalisches Inst.); Walter, R.L.; Byrd, R.C. (Duke Univ., Durham, NC (USA). Dept. of Physics; Triangle Universities Nuclear Lab., Durham, NC (USA))

    1985-03-01

    The excitation energy, spin and parity of levels in /sup 13/C have been determined for excitation energies between 13 and 16 MeV via a phase-shift analysis of the measured total cross section, elastic differential cross section and analysing power for n + /sup 12/C in the neutron energy range from 8.9 to 12.0 MeV. New analysing power measurements are reported for this energy range. The present and previous experimental data are well described by the phase shifts obtained. The non-elastic cross section for n + /sup 12/C predicted from the phase shifts is in good agreement with the ENDF/B-V evaluation. The need for further experimental data is pointed out.

  6. Phase-shift-analysis approach to elastic neutron scattering from 12C between 9 and 12 MeV

    Tornow, W.

    1985-01-01

    The excitation energy, spin and parity of levels in 13 C have been determined for excitation energies between 13 and 16 MeV via a phase-shift analysis of the measured total cross section, elastic differential cross section and analysing power for n + 12 C in the neutron energy range from 8.9 to 12.0 MeV. New analysing power measurements are reported for this energy range. The present and previous experimental data are well described by the phase shifts obtained. The non-elastic cross section for n + 12 C predicted from the phase shifts is in good agreement with the ENDF/B-V evaluation. The need for further experimental data is pointed out. (author)

  7. Effects of Napping During Shift Work on Sleepiness and Performance in Emergency Medical Services Personnel and Similar Shift Workers: A Systematic Review and Meta-Analysis.

    Martin-Gill, Christian; Barger, Laura K; Moore, Charity G; Higgins, J Stephen; Teasley, Ellen M; Weiss, Patricia M; Condle, Joseph P; Flickinger, Katharyn L; Coppler, Patrick J; Sequeira, Denisse J; Divecha, Ayushi A; Matthews, Margaret E; Lang, Eddy S; Patterson, P Daniel

    2018-02-15

    Scheduled napping during work shifts may be an effective way to mitigate fatigue-related risk. This study aimed to critically review and synthesize existing literature on the impact of scheduled naps on fatigue-related outcomes for EMS personnel and similar shift worker groups. A systematic literature review was performed of the impact of a scheduled nap during shift work on EMS personnel or similar shift workers. The primary (critical) outcome of interest was EMS personnel safety. Secondary (important) outcomes were patient safety; personnel performance; acute states of fatigue, alertness, and sleepiness; indicators of sleep duration and/or quality; employee retention/turnover; indicators of long-term health; and cost to the system. Meta-analyses were performed to evaluate the impact of napping on a measure of personnel performance (the psychomotor vigilance test [PVT]) and measures of acute fatigue. Of 4,660 unique records identified, 13 experimental studies were determined relevant and summarized. The effect of napping on reaction time measured at the end of shift was small and non-significant (SMD 0.12, 95% CI -0.13 to 0.36; p = 0.34). Napping during work did not change reaction time from the beginning to the end of the shift (SMD -0.01, 95% CI -25.0 to 0.24; p = 0.96). Naps had a moderate, significant effect on sleepiness measured at the end of shift (SMD 0.40, 95% CI 0.09 to 0.72; p = 0.01). The difference in sleepiness from the start to the end of shift was moderate and statistically significant (SMD 0.41, 95% CI 0.09 to 0.72; p = 0.01). Reviewed literature indicated that scheduled naps at work improved performance and decreased fatigue in shift workers. Further research is required to identify the optimal timing and duration of scheduled naps to maximize the beneficial outcomes.

  8. Chemosensitivity of human small cell carcinoma of the lung detected by flow cytometric DNA analysis of drug-induced cell cycle perturbations in vitro

    Engelholm, S A; Spang-Thomsen, M; Vindeløv, L L

    1986-01-01

    A method based on detection of drug-induced cell cycle perturbation by flow cytometric DNA analysis has previously been described in Ehrlich ascites tumors as a way to estimate chemosensitivity. The method is extended to test human small-cell carcinoma of the lung. Three tumors with different...... sensitivities to melphalan in nude mice were used. Tumors were disaggregated by a combined mechanical and enzymatic method and thereafter have incubated with different doses of melphalan. After incubation the cells were plated in vitro on agar, and drug induced cell cycle changes were monitored by flow...

  9. Transcriptional analysis of the conidiation pattern shift of the entomopathogenic fungus Metarhizium acridum in response to different nutrients.

    Wang, Zhenglong; Jin, Kai; Xia, Yuxian

    2016-08-09

    Most fungi, including entomopathogenic fungi, have two different conidiation patterns, normal and microcycle conidiation, under different culture conditions, eg, in media containing different nutrients. However, the mechanisms underlying the conidiation pattern shift are poorly understood. In this study, Metarhizium acridum undergoing microcycle conidiation on sucrose yeast extract agar (SYA) medium shifted to normal conidiation when the medium was supplemented with sucrose, nitrate, or phosphate. By linking changes in nutrients with the conidiation pattern shift and transcriptional changes, we obtained conidiation pattern shift libraries by Solexa/Illumina deep-sequencing technology. A comparative analysis demonstrated that the expression of 137 genes was up-regulated during the shift to normal conidiation, while the expression of 436 genes was up-regulated at the microcycle conidiation stage. A comparison of subtractive libraries revealed that 83, 216, and 168 genes were related to sucrose-induced, nitrate-induced, and phosphate-induced conidiation pattern shifts, respectively. The expression of 217 genes whose expression was specific to microcycle conidiation was further analyzed by the gene expression profiling via multigene concatemers method using mRNA isolated from M. acridum grown on SYA and the four normal conidiation media. The expression of 142 genes was confirmed to be up-regulated on standard SYA medium. Of these 142 genes, 101 encode hypothetical proteins or proteins of unknown function, and only 41 genes encode proteins with putative functions. Of these 41 genes, 18 are related to cell growth, 10 are related to cell proliferation, three are related to the cell cycle, three are related to cell differentiation, two are related to cell wall synthesis, two are related to cell division, and seven have other functions. These results indicate that the conidiation pattern shift in M. acridum mainly results from changes in cell growth and proliferation. The

  10. Analysis of a micropolarizer array-based simultaneous phase-shifting interferometer.

    Novak, Matt; Millerd, James; Brock, Neal; North-Morris, Michael; Hayes, John; Wyant, James

    2005-11-10

    Recent technological innovations have enabled the development of a new class of dynamic (vibration-insensitive) interferometer based on a CCD pixel-level phase-shifting approach. We present theoretical and experimental results for an interferometer based on this pixelated phase-shifting technique. Analyses of component errors and instrument functionality are presented. We show that the majority of error sources cause relatively small magnitude peak-to-valley errors in measurement of the order of 0.002-0.005lambda. These errors are largely mitigated by high-rate data acquisition and consequent data averaging.

  11. New evidence and impact of electron transport non-linearities based on new perturbative inter-modulation analysis

    van Berkel, M.; Kobayashi, T.; Igami, H.; Vandersteen, G.; Hogeweij, G. M. D.; Tanaka, K.; Tamura, N.; Zwart, H. J.; Kubo, S.; Ito, S.; Tsuchiya, H.; de Baar, M. R.; LHD Experiment Group

    2017-12-01

    A new methodology to analyze non-linear components in perturbative transport experiments is introduced. The methodology has been experimentally validated in the Large Helical Device for the electron heat transport channel. Electron cyclotron resonance heating with different modulation frequencies by two gyrotrons has been used to directly quantify the amplitude of the non-linear component at the inter-modulation frequencies. The measurements show significant quadratic non-linear contributions and also the absence of cubic and higher order components. The non-linear component is analyzed using the Volterra series, which is the non-linear generalization of transfer functions. This allows us to study the radial distribution of the non-linearity of the plasma and to reconstruct linear profiles where the measurements were not distorted by non-linearities. The reconstructed linear profiles are significantly different from the measured profiles, demonstrating the significant impact that non-linearity can have.

  12. An Analysis of "Rank-Shift" of Compound Complex Sentence Translation

    Widarwati, Nunun Tri

    2015-01-01

    The focus of the research is to describe the "rank-shift" of compound complex sentence translation in Harry Potter and the Order of the Phoenix novel translation by Listiana Srisanti and also to describe the accuracy of those translation. This research belongs to qualitative descriptive research which document and informants are being…

  13. Topics in phase-shift analysis and higher spin field theory

    Reisen, J.C.J.M.

    1983-01-01

    The first part of this thesis considers several aspects of the existence of phase-shift ambiguities. The subject is introduced with a few remarks on scattering theory and previous work in this area is discussed. The mathematical restrictions of presenting such problems clearly are considered and the construction of different unitary amplitudes which correspond to the same differential cross section is described. So far, examples of phase-shift ambiguities have only been found for rather special cases but the author shows that these results can be considerably generalized for spinless elastic scattering, leading to properties of phase-shift ambiguities being revealed that were previously absent. These properties are discussed in detail. Phase-shift ambiguities for the spin-0-spin-1/2 elastic scattering are then considered and again generalized. The second part of this thesis is concerned with the investigation of a free field theory for both massive and massless particles with higher spin (1, 2 and 3). A root method has been used which is described and shown to lead to the free field equations and the subsidiary conditions. A field equation and Lagrangian are constructed for massive particles and the former is then used to derive a massless field equation and Lagrangian. The relation between massive and massless field equations is investigated in more detail and particularly the expressions for the amplitude describing exchange of a particle between two external sources are compared. (Auth./C.F.)

  14. Tonic noradrenergic activity modulates explorative behavior and attentional set shifting: Evidence from pupillometry and gaze pattern analysis.

    Pajkossy, Péter; Szőllősi, Ágnes; Demeter, Gyula; Racsmány, Mihály

    2017-12-01

    A constant task for every living organism is to decide whether to exploit rewards associated with current behavior or to explore the environment for more rewarding options. Current empirical evidence indicates that exploitation is related to phasic whereas exploration is related to tonic firing mode of noradrenergic neurons in the locus coeruleus. In humans, this exploration-exploitation trade-off is subserved by the ability to flexibly switch attention between task-related and task-irrelevant information. Here, we investigated whether this function, called attentional set shifting, is related to exploration and tonic noradrenergic discharge. We measured pretrial baseline pupil dilation, proved to be strongly correlated with the activity of the locus coeruleus, while human participants took part in well-known tasks of attentional set shifting. Study 1 used the Wisconsin Card Sorting Task, whereas in Study 2, the Intra/Extradimensional Set Shifting Task was used. Both tasks require participants to choose between different compound stimuli based on feedback provided for their previous decisions. During the task, stimulus-reward contingencies change periodically, thus participants are repeatedly required to reassess which stimulus features are relevant (i.e., they shift their attentional set). Our results showed that baseline pupil diameter steadily decreased when the stimulus-reward contingencies were stable, whereas they suddenly increased when these contingencies changed. Analysis of looking patterns also confirmed the presence of exploratory behavior during attentional set shifting. Thus, our results suggest that tonic firing mode of noradrenergic neurons in the locus coeruleus is implicated in attentional set shifting, as it regulates the amount of exploration. © 2017 Society for Psychophysiological Research.

  15. Cost-effectiveness analysis of weekday and weeknight or weekend shifts for assessment of appendicitis

    Doria, Andrea S.; Babyn, Paul; Chait, Peter; Amernic, Heidi; Coyte, Peter C.; Dick, Paul; Langer, Jacob; Ungar, Wendy J.

    2005-01-01

    Assessment of appendicitis during a weeknight or weekend shift (after-hours period, AHP) might be more costly and less effective than its assessment on a weekday shift (standard hours period, SHP) because of increased costs (staff premium fees) and perforation risk (longer delays and less experience of fellows). Objectives: The objectives were to compare the costs and effectiveness of assessing children with suspected appendicitis who required a laparotomy and had US or CT after-hours with those of assessing children during standard hours, and to evaluate the importance of diagnostic imaging (DI) within the overall costs. We retrospectively microcosted resource use within six areas of a tertiary hospital (emergency [ED], diagnostic imaging (DI), surgery, wards, transport, and pathology) in a tertiary hospital. About 41 children (1.8-17 years) in the AHP and 35 (2.9-16 years) in the SHP were evaluated. Work shift effectiveness was measured with a histological score that assessed the severity of appendicitis (non-perforated appendicitis: scores 1-3; perforated appendicitis: score 4). The SHP was less costly and more effective regardless of whether the calculation included US or CT costs only. For a salary-based fee schedule, US$733 were saved per case of perforated appendicitis averted in the SHP. For a fee-for-service payment schedule, $847 were saved. Within the overall budget, the highest costs were those incurred on the ward for both shifts. The average cost per patient in DI ranged from 2 to 5% of the total costs in both shifts. Most perforation cases were found in the AHP (31.7%, AHP vs. 17.1%, SHP), which resulted in higher ward costs for patients in the AHP. (orig.)

  16. The perturbation theory in the fundamental mode. Its application to the analysis of neutronic experiments involving small amounts of materials in fast neutron multiplying media

    Remsak, Stanislav.

    1975-01-01

    The formalism of the perturbation theory at the first order, is developed in its simplest form: diffusion theory in the fundamental mode and then the more complex formalism of the transport theory in the fundamental mode. A comparison shows the effect of the angular correlation between the fine structures of the flux and its adjoint function, the difference in the treatment of neutron leakage phenomena, and the existence of new terms in the perturbation formula, entailing a reactivity representation in the diffusion theory that is not quite exact. Problems of using the formalism developed are considered: application of the multigroup formalism, transients of the flux and its adjoint function, validity of the first order approximation etc. A detailed analysis allows the formulation of a criterion specifying the validity range. Transients occuring in the reference medium are also treated. A set of numerical tests for determining a method of elimination of transient effects is presented. Some differential experiments are then discussed: sodium blowdown in enriched uranium or plutonium cores, experiments utilizing some structural materials (iron and oxygen) and plutonium sample oscillations. The Cadarache version II program was systematically used but the analysis of the experiments of plutonium sample oscillation in Ermine required the Cadarache version III program [fr

  17. [A new working shift model for anesthesiologists: an analysis 3 years after implementation].

    Maschmann, J; Holderried, M; Blumenstock, G; Rieger, M A; Bamberg, M; Rosenberger, P; Wagner, T

    2012-11-01

    The aim of this study was to assess the efficacy, appropriateness and cost-effectiveness of a new working shift model for anesthesiologists complying with the European working time directive (EWTD) at the University Hospital of Tübingen (UKT), Germany 3 years after implementation Applying the standards of the EWTD is challenging for university hospitals as doctors must comply with the challenge of combining patient care, research and teaching. So far there have been no data available for German university hospitals on how these requirements can be met. As the department of anesthesiology is also a service-providing department it is essential not to increase staffing costs with a new shift model. In 2007 a new working shift model for the department of anesthesiology was designed and introduced in 2008. Shift planning and documentation of working hours were implemented electronically. The calculated number of doctors to run this model was 87.6 full time equivalents (FTE). For 2009 and 2010 the compliance with the EWTD parameters was checked for 1) average weekly working time limit (AWWTL) and 2) compliance to the maximum daily working time limit of 10 h (10 h DWTL). Furthermore, staffing costs for doctors in 2010 were compared to 2007. To check for the time spent in patient care the period of anesthetic attendance (PAA) was chosen, i.e. the total time of patient contact by anesthesiology staff. Data were analyzed descriptively for AWWTL and for 10 h DWTL. FTE, staff costs and PAA were evaluated by one-way ANOVA. The new shift model allowed 84.4 % of all doctors to comply with the individual AWWT limits of 54 h and 48 h in 2009 (81/96) and 76.0 % in 2010 (79/104). In 2009 61.5 % of anesthesiologists voted for opt-out (59/96) and 53.8 % did so in 2010 (56/104). The 10 h DWTL was respected by 84.0 % in 2009 and by 85.9 % in 2010. The mean number of anesthesiologists rose significantly from 78.4 FTE in 2007 to 82.5 FTE in 2009 and 84.6 FTE in 2010 (p

  18. Status of perturbative QCD

    Collins, J.C.

    1985-01-01

    Progress in quantum chromodynamics in the past year is reviewed in these specific areas: proof of factorization for hadron-hadron collisions, fast calculation of higher order graphs, perturbative Monte Carlo calculations for hadron-hadron scattering, applicability of perturbative methods to heavy quark production, and understanding of the small-x problem. 22 refs

  19. Perturbative and constructive renormalization

    Veiga, P.A. Faria da

    2000-01-01

    These notes are a survey of the material treated in a series of lectures delivered at the X Summer School Jorge Andre Swieca. They are concerned with renormalization in Quantum Field Theories. At the level of perturbation series, we review classical results as Feynman graphs, ultraviolet and infrared divergences of Feynman integrals. Weinberg's theorem and Hepp's theorem, the renormalization group and the Callan-Symanzik equation, the large order behavior and the divergence of most perturbation series. Out of the perturbative regime, as an example of a constructive method, we review Borel summability and point out how it is possible to circumvent the perturbation diseases. These lectures are a preparation for the joint course given by professor V. Rivasseau at the same school, where more sophisticated non-perturbative analytical methods based on rigorous renormalization group techniques are presented, aiming at furthering our understanding about the subject and bringing field theoretical models to a satisfactory mathematical level. (author)

  20. Proton-deuteron phase-shift analysis above the deuteron breakup threshold

    Tornow, W. [Duke Univ., Durham, NC (United States). Dept. of Physics]|[Triangle Universities Nuclear Laboratory, Box 90308, Durham, NC (United States); Witala, H. [Institute of Physics, Jagellonian University, Reymonta 4, 30059 Cracow (Poland)

    1998-03-02

    We have performed single-energy phase-shift analyses of proton-deuteron elastic scattering data in the proton energy range from 3.5 to 10 MeV. The resulting values for the {sup 2}S{sub 1/2} and {sup 4}P{sub 1/2}, {sup 4}P{sub 3/2}, and {sup 4}P{sub 5/2} phase shifts are important benchmark values for three-nucleon calculations based on nucleon-nucleon potential models (with and without three-nucleon forces) aimed at describing the triton binding energy and at resolving the nucleon-deuteron A{sub y}({theta}) and iT{sub 11}({theta}) puzzles, respectively. (orig.) 7 refs.

  1. Desynchronization Chaos Shift Keying Method Based on the Error Second Derivative and Its Security Analysis

    Čelikovský, Sergej; Lynnyk, Volodymyr

    2012-01-01

    Roč. 22, č. 9 (2012), 1250231-1-1250231-11 ISSN 0218-1274 R&D Projects: GA ČR(CZ) GAP103/12/1794 Institutional support: RVO:67985556 Keywords : Nonlinear system * desynchronization * chaos shift keying * generalized Lorenz system Subject RIV: BC - Control Systems Theory Impact factor: 0.921, year: 2012 http://library.utia.cas.cz/separaty/2012/TR/celikovsky-0381701.pdf

  2. Conformational analysis of the chemical shifts for molecules containing diastereotopic methylene protons

    Borowski, Piotr

    2012-01-01

    Quantum chemistry SCF/GIAO calculations were carried out on a set of compounds containing diastereotopic protons. Five molecules, including recently synthesized 1,3-di(2,3-epoxypropoxy)benzene, containing the chiral or pro-chiral center and the neighboring methylene group, were chosen. The rotational averages (i.e. normalized averages with respect to the rotation about the torsional angle τ with the exponential energy weight at temperature T) calculated individually for each of the methylene protons in 1,3-di(2,3-epoxypropoxy)benzene differ by ca. 0.6 ppm, which is significantly less than the value calculated for the lowest energy conformer. This value turned out to be low enough to guarantee the proper ordering of theoretical chemical shifts, supporting the interpretation of the 1H NMR spectrum of this important compound. The rotational averages of chemical shifts for methylene protons for a given type of conformer are shown to be essentially equal to the Boltzmann averages (here, the population-weighted averages for the individual conformers representing minima on the E( τ) cross-section). The calculated Boltzmann averages in the representative conformational space may exhibit completely different ordering as compared to the chemical shifts calculated for the lowest-energy conformer. This is especially true in the case of molecules, for which no significant steric effects are present. In this case, only Boltzmann averages account for the experimental pattern of proton signals. In addition, better overall agreement with experiment (lower value of the root-mean-square deviation between calculated and measured chemical shifts) is typically obtained when Boltzmann averages are used.

  3. Analysis of ductile-brittle transition shifts for standard and miniature bending specimens of irradiated steel

    Korshunov, M.E.; Korolev, Yu.N.; Krasikov, E.A.; Gabuev, N.N.; Tykhmeev, D.Yu.

    1996-01-01

    A study is made to reveal if there is a correlation between shifts in temperature curves obtained when testing thin plates and standard specimens on impact bending and fracture toughness. The tests were carried out using steel 25Kh3NM specimens irradiated by 6 x 10 19 cm -2 neutron fluence. A conclusion is made about the possibility to evaluate the degree of radiation-induced embrittlement of reactor steels on the basis of thin plate testing under quasistatic loads [ru

  4. Differential Shift Estimation in the Absence of Coherence: Performance Analysis and Benefits of Polarimetry

    Villano, Michelangelo; Papathanassiou, Konstantinos P.

    2011-03-01

    The estimation of the local differential shift between synthetic aperture radar (SAR) images has proven to be an effective technique for monitoring glacier surface motion. As images acquired over glaciers by short wavelength SAR systems, such as TerraSAR-X, often suffer from a lack of coherence, image features have to be exploited for the shift estimation (feature-tracking).The present paper addresses feature-tracking with special attention to the feasibility requirements and the achievable accuracy of the shift estimation. In particular, the dependence of the performance on image characteristics, such as texture parameters, signal-to-noise ratio (SNR) and resolution, as well as on processing techniques (despeckling, normalised cross-correlation versus maximum likelihood estimation) is analysed by means of Monte-Carlo simulations. TerraSAR-X data acquired over the Helheim glacier, Greenland, and the Aletsch glacier, Switzerland, have been processed to validate the simulation results.Feature-tracking can benefit of the availability of fully-polarimetric data. As some image characteristics, in fact, are polarisation-dependent, the selection of an optimum polarisation leads to improved performance. Furthermore, fully-polarimetric SAR images can be despeckled without degrading the resolution, so that additional (smaller-scale) features can be exploited.

  5. Dynamics of a modified Hindmarsh-Rose neural model with random perturbations: Moment analysis and firing activities

    Mondal, Argha; Upadhyay, Ranjit Kumar

    2017-11-01

    In this paper, an attempt has been made to understand the activity of mean membrane voltage and subsidiary system variables with moment equations (i.e., mean, variance and covariance's) under noisy environment. We consider a biophysically plausible modified Hindmarsh-Rose (H-R) neural system injected by an applied current exhibiting spiking-bursting phenomenon. The effects of predominant parameters on the dynamical behavior of a modified H-R system are investigated. Numerically, it exhibits period-doubling, period halving bifurcation and chaos phenomena. Further, a nonlinear system has been analyzed for the first and second order moments with additive stochastic perturbations. It has been solved using fourth order Runge-Kutta method and noisy systems by Euler's scheme. It has been demonstrated that the firing properties of neurons to evoke an action potential in a certain parameter space of the large exact systems can be estimated using an approximated model. Strong stimulation can cause a change in increase or decrease of the firing patterns. Corresponding to a fixed set of parameter values, the firing behavior and dynamical differences of the collective variables of a large, exact and approximated systems are investigated.

  6. An integral equation for the continuation of perturbative expansions

    Ciulli, S.

    1984-01-01

    It is shown how a procedure for analytic continuation, based on methods of functional analysis, can be used to extend the results of a perturbative calculation to yield nonperturbative information which could not be obtained directly from a perturbative expansion

  7. Non-leading contributions in QCD: Summing the perturbative series

    Trentadue, L.

    1984-01-01

    This paper presents the results of a systematic analysis of the leading and non-leading contributions in perturbative QCD and addresses the question of logarithmic contributions to all orders of the perturbative series

  8. Delineating social network data anonymization via random edge perturbation

    Xue, Mingqiang; Karras, Panagiotis; Raï ssi, Chedy; Kalnis, Panos; Pung, Hungkeng

    2012-01-01

    study of the probability of success of any}structural attack as a function of the perturbation probability. Our analysis provides a powerful tool for delineating the identification risk of perturbed social network data; our extensive experiments

  9. Gel shift analysis of the empA promoter region in Vibrio anguillarum

    Denkin Steven M

    2004-10-01

    Full Text Available Abstract Background The induction of metalloprotease encoded by empA in Vibrio anguillarum occurs at high cell density in salmon intestinal mucus. Previously we have shown that there are significant differences in empA expression in two strains of V. anguillarum, M93Sm and NB10. It is hypothesized that differences in empA regulation are due to differences in binding of regulatory elements. Results Two strains of V. anguillarum, M93Sm and NB10, were examined and compared for the presence of DNA regulatory proteins that bind to and control the empA promoter region. Gel mobility shift assays, using a digoxigenin (DIG-labeled oligomer containing a lux box-like element and the promoter for empA, were done to demonstrate the presence of a DNA-binding protein. Protein extracts from NB10 cells incubated in Luria Bertani broth + 2% NaCl (LB20, nine salts solution + 200 μg/ml mucus (NSSM, 3M (marine minimal medium, or NSS resulted in a gel mobility shift. No gel mobility shift was seen when protein extracts from either LB20- or NSSM-grown M93Sm cells were mixed with the DIG-labeled empA oligomer. The azocasein assay detected protease activity in all incubation conditions for NB10 culture supernatants. In contrast, protease activity was detected in M93Sm culture supernatants only when incubated in NSSM. Since the luxR homologue in V. anguillarum, vanT, has been cloned, sequenced, and shown to be required for protease activity, we wanted to determine if vanT mutants of NB10 exhibit the same gel shift observed in the wild-type. Site-directed mutagenesis was used to create vanT mutants in V. anguillarum M93Sm and NB10 to test whether VanT is involved with the gel mobility shift. Both vanT mutants, M02 and NB02, did not produce protease activity in any conditions. However, protein extracts from NB02 incubated in each condition still exhibited a gel shift when mixed with the DIG-labeled empA oligomer. Conclusions The data demonstrate that protein extracts of V

  10. The effects of static quartic anharmonicity on the quantum dynamics of a linear oscillator with time-dependent harmonic frequency: Perturbative analysis and numerical calculations

    Sarkar, P.; Bhattacharyya, S.P.

    1995-01-01

    The effects of quartic anharmonicity on the quantum dynamics of a linear oscillator with time-dependent force constant (K) or harmonic frequency (ω) are studied both perturbatively and numerically by the time-dependent Fourier grid Hamiltonian method. In the absence of anharmonicity, the ground-state population decreases and the population of an accessible excited state (k = 2.4, 6 ... ) increases with time. However, when anharmonicity is introduced, both the ground- and excited-state populations show typical oscillations. For weak coupling, the population of an accessible excited state at a certain instant of time (short) turns out to be a parabolic function of the anharmonic coupling constant (λ), when all other parameters of the system are kept fixed. This parabolic nature of the excited-state population vs. the λ profile is independent of the specific form of the time dependence of the force constant, K t . However, it depends upon the rate at which K t relaxes. For small anharmonic coupling strength and short time scales, the numerical results corroborate expectations based on the first-order time-dependent perturbative analysis, using a suitably repartitioned Hamiltonian that makes H 0 time-independent. Some of the possible experimental implications of our observations are analyzed, especially in relation to intensity oscillations observed in some charge-transfer spectra in systems in which the dephasing rates are comparable with the time scale of the electron transfer. 21 refs., 7 figs., 1 tab

  11. The big contradiction between the perturbation theory and the chaotic state. A detailed mathematical analysis indicates when the plasma is stable or unstable

    Xaplanteris, C. L.; Xaplanteris, S. C.

    2016-01-01

    In the present manuscript enough observations and interpretations of three issues of Plasma Physics are presented. The first issue is linked to the common experimental confirmation of plasma waves which appear to be repeated in a standard way while there are also cases where plasma waves change to an unstable state or even to chaotic state. The second issue is associated with a mathematical analysis of the movement of a charged particle using the perturbation theory; which could be used as a guide for new researchers on similar issues. Finally, the suitability and applicability of the perturbation theory or the chaotic theory is presented. Although this study could be conducted on many plasma phenomena (e.g. plasma diffusion) or plasma quantities (e.g. plasma conductivity), here it was decided this study to be conducted on plasma waves and particularly on drift waves. This was because of the significance of waves on the plasmatic state and especially their negative impact on the thermonuclear fusion, but also due to the long-time experience of the plasma laboratory of Demokritos on drift waves.

  12. A perturbative DFT approach for magnetic anisotropy

    Khoo, Khoong Hong; Laskowski, Robert, E-mail: rolask@ihpc.a-star.edu.sg

    2017-04-15

    We develop a perturbative formalism for computing magnetocrystalline anisotropy within density functional theory and the magnetic force theorem. Instead of computing eigenvalues of the spin–orbit Hamiltonian for selected spin polarizations, as in the conventional “force theorem” approach, we show that the effect can be cast into a redefined form of the spin–orbit operator. This allows to separate the large eigenvalue shift due to spin-orbit interaction common for both polarizations from the much smaller magnetic anisotropy splitting. As a consequence the anisotropy splitting may by considered as a perturbation.

  13. Interleukin-6 Level among Shift and Night Workers in Japan: Cross-Sectional Analysis of the J-HOPE Study.

    Amano, Hoichi; Fukuda, Yoshiharu; Yokoo, Takashi; Yamaoka, Kazue

    2018-03-27

    Shift workers have a high risk of cardiovascular disease (CVD). Systemic inflammation measured has been associated with the risk of CVD onset, in addition to classical risk factors. However, the association between work schedule and inflammatory cytokine levels remains unclear. The purpose of this study was to examine the association between work schedule and interleukin-6 (IL-6)/high-sensitivity C-reactive protein (hs-CRP) levels among Japanese workers. The present cross-sectional study was a part of the Japanese Study of Health, Occupation and Psychosocial Factors Related Equity (J-HOPE). A total of 5259 persons who measured inflammatory cytokine were analyzed in this study. One-way analysis of variance was used to test log-transformed IL-6/hs-CRP differences by work schedule. Multiple regression analysis was used to examine the difference adjusted for other possible CVD risk factors. There were 3660 participants who had a regular work schedule; the remaining schedules were shift work without night work for 181 participants, shift work with night work for 1276 participants, and only night work for 142 participants. The unadjusted model showed that only night workers were significantly related to high levels of IL-6 compared with regular workers. Even in the multiple regression analysis, the higher level of IL-6 among only night workers remained significant (β=0.058, P=0.01). On the contrary, hs-CRP was not. The present study revealed that only night shift work is significantly associated with high levels of IL-6 in Japanese workers. These observations help us understand the mechanism for the association between work schedule and CVD onset.

  14. Time allocation shifts and pollutant exposure due to traffic congestion: an analysis using the national human activity pattern survey.

    Zhang, Kai; Batterman, Stuart A

    2009-10-15

    Traffic congestion increases air pollutant exposures of commuters and urban populations due to the increased time spent in traffic and the increased vehicular emissions that occur in congestion, especially "stop-and-go" traffic. Increased time in traffic also decreases time in other microenvironments, a trade-off that has not been considered in previous time activity pattern (TAP) analyses conducted for exposure assessment purposes. This research investigates changes in time allocations and exposures that result from traffic congestion. Time shifts were derived using data from the National Human Activity Pattern Survey (NHAPS), which was aggregated to nine microenvironments (six indoor locations, two outdoor locations and one transport location). After imputing missing values, handling outliers, and conducting other quality checks, these data were stratified by respondent age, employment status and period (weekday/weekend). Trade-offs or time-shift coefficients between time spent in vehicles and the eight other microenvironments were then estimated using robust regression. For children and retirees, congestion primarily reduced the time spent at home; for older children and working adults, congestion shifted the time spent at home as well as time in schools, public buildings, and other indoor environments. Changes in benzene and PM(2.5) exposure were estimated for the current average travel delay in the U.S. (9 min day(-1)) and other scenarios using the estimated time shifts coefficients, concentrations in key microenvironments derived from the literature, and a probabilistic analysis. Changes in exposures depended on the duration of the congestion and the pollutant. For example, a 30 min day(-1) travel delay was determined to account for 21+/-12% of current exposure to benzene and 14+/-8% of PM(2.5) exposure. The time allocation shifts and the dynamic approach to TAPs improve estimates of exposure impacts from congestion and other recurring events.

  15. Effects of Napping During Shift Work on Sleepiness and Performance in Emergency Medical Services Personnel and Similar Shift Workers: A Systematic Review and Meta-Analysis

    2018-01-11

    Background: Scheduled napping during work shifts may be an effective way to mitigate fatigue-related risk. This study aimed to critically review and synthesize existing literature on the impact of scheduled naps on fatigue-related outcomes for EMS pe...

  16. Reduced Tolerance to Night Shift in Chronic Shift Workers: Insight From Fractal Regulation.

    Li, Peng; Morris, Christopher J; Patxot, Melissa; Yugay, Tatiana; Mistretta, Joseph; Purvis, Taylor E; Scheer, Frank A J L; Hu, Kun

    2017-07-01

    Healthy physiology is characterized by fractal regulation (FR) that generates similar structures in the fluctuations of physiological outputs at different time scales. Perturbed FR is associated with aging and age-related pathological conditions. Shift work, involving repeated and chronic exposure to misaligned environmental and behavioral cycles, disrupts circadian coordination. We tested whether night shifts perturb FR in motor activity and whether night shifts affect FR in chronic shift workers and non-shift workers differently. We studied 13 chronic shift workers and 14 non-shift workers as controls using both field and in-laboratory experiments. In the in-laboratory study, simulated night shifts were used to induce a misalignment between the endogenous circadian pacemaker and the sleep-wake cycles (ie, circadian misalignment) while environmental conditions and food intake were controlled. In the field study, we found that FR was robust in controls but broke down in shift workers during night shifts, leading to more random activity fluctuations as observed in patients with dementia. The night shift effect was present even 2 days after ending night shifts. The in-laboratory study confirmed that night shifts perturbed FR in chronic shift workers and showed that FR in controls was more resilience to the circadian misalignment. Moreover, FR during real and simulated night shifts was more perturbed in those who started shift work at older ages. Chronic shift work causes night shift intolerance, which is probably linked to the degraded plasticity of the circadian control system. © Sleep Research Society 2017. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.

  17. Shift work, night work, and the risk of prostate cancer: A meta-analysis based on 9 cohort studies.

    Du, Hong-Bing; Bin, Kai-Yun; Liu, Wen-Hong; Yang, Feng-Sheng

    2017-11-01

    Epidemiology studies suggested that shift work or night work may be linked to prostate cancer (PCa); the relationship, however, remains controversy. PubMed, ScienceDirect, and Embase (Ovid) databases were searched before (started from the building of the databases) February 4, 2017 for eligible cohort studies. We pooled the evidence included by a random- or fixed-effect model, according to the heterogeneity. A predefined subgroup analysis was conducted to see the potential discrepancy between groups. Sensitivity analysis was used to test whether our results were stale. Nine cohort studies were eligible for meta-analysis with 2,570,790 male subjects. Our meta-analysis showed that, under the fixed-effect model, the pooled relevant risk (RR) of PCa was 1.05 (95% confidence interval [CI]: 1.00, 1.11; P = .06; I = 24.00%) for men who had ever engaged in night shift work; and under the random-effect model, the pooled RR was 1.08 (0.99, 1.17; P = .08; I = 24.00%). Subgroup analysis showed the RR of PCa among males in western countries was 1.05 (95% CI: 0.99, 1.11; P = .09; I = 0.00%), while among Asian countries it was 2.45 (95% CI: 1.19, 5.04; P = .02; I = 0.00%); and the RR was 1.04 (95% CI: 0.95, 1.14; P = .40; I = 29.20%) for the high-quality group compared with 1.21 (95% CI: 1.03, 1.41; P = .02; I = 0.00%) for the moderate/low-quality group. Sensitivity analysis showed robust results. Based on the current evidence of cohort studies, we found no obvious association between night shift work and PCa. However, our subgroup analysis suggests that night shift work may increase the risk of PCa in Asian men. Some evidence of a small study effect was observed in this meta-analysis.

  18. Lamb shift in muonic hydrogen-II. Analysis of the discrepancy of theory and experiment

    Jentschura, U.D.

    2011-01-01

    Research highlights: → Various theoretical explanation for the recently observed experimental-theoretical discrepancy in the muonic hydrogen Lamb shift are explored. → These include a dip in the proton form factor slope, nonperturbative vacuum polarization and millicharged virtual particles, as well as process-dependent screening corrections. → Screening corrections may need to be explored further. → The need for an alternative determination of the Rydberg constant is highlighted. - Abstract: Currently, both the g factor measurement of the muon as well as the Lamb shift 2S-2P measurement in muonic hydrogen are in disagreement with theory. Here, we investigate possible theoretical explanations, including proton structure effects and small modifications of the vacuum polarization potential. In particular, we investigate a conceivable small modification of the spectral function of vacuum polarization in between the electron and muon energy scales due to a virtual millicharged particle and due to an unstable vector boson originating from a hidden sector of an extended standard model. We find that a virtual millicharged particle which could explain the muonic Lamb shift discrepancy alters theoretical predictions for the muon anomalous magnetic moment by many standard deviations and therefore is in conflict with experiment. Also, we find no parameterizations of an unstable virtual vector boson which could simultaneously explain both 'muonic' discrepancies without significantly altering theoretical predictions for electronic hydrogen, where theory and experiment currently are in excellent agreement. A process-dependent correction involving electron screening is evaluated to have the right sign and order-of-magnitude to explain the observed effect in muonic hydrogen. Additional experimental evidence from light muonic atoms and ions is needed in order to reach further clarification.

  19. Phase-shift analysis of neutron-209Bi scattering and its comparison to neutron-208Pb scattering

    Chen, Z.P.; Tornow, W.; Walter, R.L.

    1995-01-01

    Published n- 209 Bi elastic differential cross-section, analyzing power, and total cross-section data in the energy range from 1.5 to 14 MeV were analyzed via a phase-shift analysis in order to find out whether these data show similar, unexplained resonance structures as observed recently for n- 208 Pb scattering. Although the n- 209 Bi and n- 208 Pb data are very similar, some of the phase shifts are quite different for the two systems. Only one resonancelike structure was observed for n- 209 Bi scattering in the excitation energy range from 9 to 18 MeV compared to eleven in the n- 208 Pb system, implying that n- 209 Bi data are probably more suitable than the classical n- 208 Pb system for detailed mean-field analyses approached through dispersion-relation optical models

  20. Non-adiabatic perturbations in multi-component perfect fluids

    Koshelev, N.A., E-mail: koshna71@inbox.ru [Ulyanovsk State University, Leo Tolstoy str 42, 432970 (Russian Federation)

    2011-04-01

    The evolution of non-adiabatic perturbations in models with multiple coupled perfect fluids with non-adiabatic sound speed is considered. Instead of splitting the entropy perturbation into relative and intrinsic parts, we introduce a set of symmetric quantities, which also govern the non-adiabatic pressure perturbation in models with energy transfer. We write the gauge invariant equations for the variables that determine on a large scale the non-adiabatic pressure perturbation and the rate of changes of the comoving curvature perturbation. The analysis of evolution of the non-adiabatic pressure perturbation has been made for several particular models.

  1. Non-adiabatic perturbations in multi-component perfect fluids

    Koshelev, N.A.

    2011-01-01

    The evolution of non-adiabatic perturbations in models with multiple coupled perfect fluids with non-adiabatic sound speed is considered. Instead of splitting the entropy perturbation into relative and intrinsic parts, we introduce a set of symmetric quantities, which also govern the non-adiabatic pressure perturbation in models with energy transfer. We write the gauge invariant equations for the variables that determine on a large scale the non-adiabatic pressure perturbation and the rate of changes of the comoving curvature perturbation. The analysis of evolution of the non-adiabatic pressure perturbation has been made for several particular models

  2. Stability of vertical posture explored with unexpected mechanical perturbations: synergy indices and motor equivalence.

    Yamagata, Momoko; Falaki, Ali; Latash, Mark L

    2018-03-21

    We explored the relations between indices of mechanical stability of vertical posture and synergy indices under unexpected perturbations. The main hypotheses predicted higher posture-stabilizing synergy indices and higher mechanical indices of center of pressure stability during perturbations perceived by subjects as less challenging. Healthy subjects stood on a force platform and held in fully extended arms a bar attached to two loads acting downward and upward. One of the loads was unexpectedly released by the experimenter causing a postural perturbations. In different series, subjects either knew or did not know which of the two loads would be released. Forward perturbations were perceived as more challenging and accompanied by co-activation patterns among the main agonist-antagonist pairs. Backward perturbation led to reciprocal muscle activation patterns and was accompanied by indices of mechanical stability and of posture-stabilizing synergy which indicated higher stability. Changes in synergy indices were observed as early as 50-100 ms following the perturbation reflecting involuntary mechanisms. In contrast, predictability of perturbation direction had weak or no effect on mechanical and synergy indices of stability. These observations are interpreted within a hierarchical scheme of synergic control of motor tasks and a hypothesis on the control of movements with shifts of referent coordinates. The findings show direct correspondence between stability indices based on mechanics and on the analysis of multi-muscle synergies. They suggest that involuntary posture-stabilizing mechanisms show synergic organization. They also show that predictability of perturbation direction has strong effects on anticipatory postural adjustment but not corrective adjustments. We offer an interpretation of co-activation patterns that questions their contribution to postural stability.

  3. A multi-model analysis of risk of ecosystem shifts under climate change

    Warszawski, Lila; Ostberg, Sebastian; Frieler, Katja; Lucht, Wolfgang; Schaphoff, Sibyll; Buechner, Matthias; Piontek, Franziska; Friend, Andrew; Keribin, Rozenn; Rademacher, Tim Tito; Beerling, David; Lomas, Mark; Cadule, Patricia; Ciais, Philippe; Clark, Douglas B; Kahana, Ron; Ito, Akihiko; Nishina, Kazuya; Kleidon, Axel; Pavlick, Ryan

    2013-01-01

    Climate change may pose a high risk of change to Earth’s ecosystems: shifting climatic boundaries may induce changes in the biogeochemical functioning and structures of ecosystems that render it difficult for endemic plant and animal species to survive in their current habitats. Here we aggregate changes in the biogeochemical ecosystem state as a proxy for the risk of these shifts at different levels of global warming. Estimates are based on simulations from seven global vegetation models (GVMs) driven by future climate scenarios, allowing for a quantification of the related uncertainties. 5–19% of the naturally vegetated land surface is projected to be at risk of severe ecosystem change at 2 ° C of global warming (ΔGMT) above 1980–2010 levels. However, there is limited agreement across the models about which geographical regions face the highest risk of change. The extent of regions at risk of severe ecosystem change is projected to rise with ΔGMT, approximately doubling between ΔGMT = 2 and 3 ° C, and reaching a median value of 35% of the naturally vegetated land surface for ΔGMT = 4 °C. The regions projected to face the highest risk of severe ecosystem changes above ΔGMT = 4 °C or earlier include the tundra and shrublands of the Tibetan Plateau, grasslands of eastern India, the boreal forests of northern Canada and Russia, the savanna region in the Horn of Africa, and the Amazon rainforest. (letter)

  4. Perturbative QCD and jets

    Mueller, A.H.

    1986-03-01

    A brief review of some of the recent progress in perturbative QCD is given (heavy quark production, small-x physics, minijets and related topics, classical simulations in high energy reactions, coherence and the string effect)

  5. Generalized chiral perturbation theory

    Knecht, M.; Stern, J.

    1994-01-01

    The Generalized Chiral Perturbation Theory enlarges the framework of the standard χPT (Chiral Perturbation Theory), relaxing certain assumptions which do not necessarily follow from QCD or from experiment, and which are crucial for the usual formulation of the low energy expansion. In this way, experimental tests of the foundations of the standard χPT become possible. Emphasis is put on physical aspects rather than on formal developments of GχPT. (author). 31 refs

  6. Shifting Attention

    Ingram, Jenni

    2014-01-01

    This article examines the shifts in attention and focus as one teacher introduces and explains an image that represents the processes involved in a numeric problem that his students have been working on. This paper takes a micro-analytic approach to examine how the focus of attention shifts through what the teacher and students do and say in the…

  7. Perturbation analysis of magnetohydrodynamics oscillatory flow on convective-radiative heat and mass transfer of micropolar fluid in a porous medium with chemical reaction

    Dulal Pal

    2016-03-01

    Full Text Available This paper deals with the perturbation analysis of mixed convection heat and mass transfer of an oscillatory viscous electrically conducting micropolar fluid over an infinite moving permeable plate embedded in a saturated porous medium in the presence of transverse magnetic field. Analytical solutions are obtained for the governing basic equations. The effects of permeability, chemical reaction, viscous dissipation, magnetic field parameter and thermal radiation on the velocity distribution, micro-rotation, skin friction and wall couple stress coefficients are analyzed in detail. The results indicate that the effect of increasing the chemical reaction has a tendency to decrease the skin friction coefficient at the wall, while opposite trend is seen by increasing the permeability parameter of the porous medium. Also micro-rotational velocity distribution increases with an increase in the magnetic field parameter.

  8. The applicability of shift-share analysis in considering employment impacts as applied to investments in nuclear power

    McGuire, A.

    1982-01-01

    An unresolved issue in the continuing debate between the proponents of nuclear power and alternative energy supplies concerns the employment impacts associated with the capital investments required by these different energy sources. Such employment impacts are properly defined as the impact of capital projects upon the local labour market and should not be confined merely to the direct employment associated with new investments. This paper attempts to highlight the local employment impacts associated with the investment in nuclear power stations by examining the effect past investments in such stations have had upon employment and unemployment trends in certain localities. Our analysis is based upon the nuclear power station developments at Hunterston in Ayrshire and Dounreay in Caithness. This allows us to consider and compare the employment impacts of nuclear power stations on a relatively underdeveloped area and an industrialized area. The employment analysis carried out below was based upon employment and unemployment trends and shift-share analysis. Shift-share analysis is not definitive, as we shall suggest below, but it is held to adequately describe local labour market conditions. (author)

  9. Applicability of shift-share analysis in considering employment impacts as applied to investments in nuclear power

    McGuire, A

    1982-01-01

    An unresolved issue in the continuing debate between the proponents of nuclear power and alternative energy supplies concerns the employment impacts associated with the capital investments required by these different energy sources. Such employment impacts are properly defined as the impact of capital projects upon the local labour market and should not be confined merely to the direct employment associated with new investments. This paper attempts to highlight the local employment impacts associated with the investment in nuclear power stations by examining the effect past investments in such stations have had upon employment and unemployment trends in certain localities. Our analysis is based upon the nuclear power station developments at Hunterston in Ayrshire and Dounreay in Caithness. This allows us to consider and compare the employment impacts of nuclear power stations on a relatively underdeveloped area and an industrialized area. The employment analysis carried out below was based upon employment and unemployment trends and shift-share analysis. Shift-share analysis is not definitive, as we shall suggest below, but it is held to adequately describe local labour market conditions.

  10. Perturbation measurement of waveguides for acoustic thermometry

    Lin, H.; Feng, X. J.; Zhang, J. T.

    2013-09-01

    Acoustic thermometers normally embed small acoustic transducers in the wall bounding a gas-filled cavity resonator. At high temperature, insulators of transducers loss electrical insulation and degrade the signal-to-noise ratio. One essential solution to this technical trouble is to couple sound by acoustic waveguides between resonator and transducers. But waveguide will break the ideal acoustic surface and bring perturbations(Δf+ig) to the ideal resonance frequency. The perturbation model for waveguides was developed based on the first-order acoustic theory in this paper. The frequency shift Δf and half-width change g caused by the position, length and radius of waveguides were analyzed using this model. Six different length of waveguides (52˜1763 mm) were settled on the cylinder resonator and the perturbation (Δf+ig) were measured at T=332 K and p=250˜500 kPa. The experiment results agreed with the theoretical prediction very well.

  11. Sector-based political analysis of energy transition: Green shift in the forest policy regime in France

    Sergent, Arnaud

    2014-01-01

    This article examines energy transition political process from a sector-based approach, through the analysis of recent shift in the French forest policy regime. We demonstrate that, since 2007, energy transition policies have led to a harvesting turn within the French forest policy framework, meaning that priority is given to wood mobilisation, mainly for biomass uses. In addition, our findings suggest that the political authority wielded by the state over forest policy has shifted from forest administrative services to energy agencies and local authorities. Finally, we show that, although implementation of the harvesting turn is a cause of sectoral and inter-sectoral tensions, energy transition challenge also contributes to a process of (re)institutionalisation of mediation relationships among forestry stakeholders and wood-based industries representatives. The article concludes by arguing that sectors should retain relevant institutional frameworks for actors when choosing political arrangements required for implementing energy transition policy. - Highlights: • Implementing energy transition policy potentially challenges sector-based politics. • We propose a policy regime framework and socio-political investigations. • We analyse the political impact of energy transition policy on French forest sector. • Shifts occur in sectoral policy framework, authority, and mediation relationships

  12. Protein energetic conformational analysis from NMR chemical shifts (PECAN) and its use in determining secondary structural elements

    Eghbalnia, Hamid R.; Wang Liya; Bahrami, Arash [National Magnetic Resonance Facility at Madison, Biochemistry Department (United States); Assadi, Amir [University of Wisconsin-Madison, Mathematics Department (United States); Markley, John L. [National Magnetic Resonance Facility at Madison, Biochemistry Department (United States)], E-mail: eghbalni@nmrfam.wisc.edu

    2005-05-15

    We present an energy model that combines information from the amino acid sequence of a protein and available NMR chemical shifts for the purposes of identifying low energy conformations and determining elements of secondary structure. The model ('PECAN', Protein Energetic Conformational Analysis from NMR chemical shifts) optimizes a combination of sequence information and residue-specific statistical energy function to yield energetic descriptions most favorable to predicting secondary structure. Compared to prior methods for secondary structure determination, PECAN provides increased accuracy and range, particularly in regions of extended structure. Moreover, PECAN uses the energetics to identify residues located at the boundaries between regions of predicted secondary structure that may not fit the stringent secondary structure class definitions. The energy model offers insights into the local energetic patterns that underlie conformational preferences. For example, it shows that the information content for defining secondary structure is localized about a residue and reaches a maximum when two residues on either side are considered. The current release of the PECAN software determines the well-defined regions of secondary structure in novel proteins with assigned chemical shifts with an overall accuracy of 90%, which is close to the practical limit of achievable accuracy in classifying the states.

  13. Protein energetic conformational analysis from NMR chemical shifts (PECAN) and its use in determining secondary structural elements

    Eghbalnia, Hamid R.; Wang Liya; Bahrami, Arash; Assadi, Amir; Markley, John L.

    2005-01-01

    We present an energy model that combines information from the amino acid sequence of a protein and available NMR chemical shifts for the purposes of identifying low energy conformations and determining elements of secondary structure. The model ('PECAN', Protein Energetic Conformational Analysis from NMR chemical shifts) optimizes a combination of sequence information and residue-specific statistical energy function to yield energetic descriptions most favorable to predicting secondary structure. Compared to prior methods for secondary structure determination, PECAN provides increased accuracy and range, particularly in regions of extended structure. Moreover, PECAN uses the energetics to identify residues located at the boundaries between regions of predicted secondary structure that may not fit the stringent secondary structure class definitions. The energy model offers insights into the local energetic patterns that underlie conformational preferences. For example, it shows that the information content for defining secondary structure is localized about a residue and reaches a maximum when two residues on either side are considered. The current release of the PECAN software determines the well-defined regions of secondary structure in novel proteins with assigned chemical shifts with an overall accuracy of 90%, which is close to the practical limit of achievable accuracy in classifying the states

  14. Analysis of protein stability and ligand interactions by thermal shift assay.

    Huynh, Kathy; Partch, Carrie L

    2015-02-02

    Purification of recombinant proteins for biochemical assays and structural studies is time-consuming and presents inherent difficulties that depend on the optimization of protein stability. The use of dyes to monitor thermal denaturation of proteins with sensitive fluorescence detection enables rapid and inexpensive determination of protein stability using real-time PCR instruments. By screening a wide range of solution conditions and additives in a 96-well format, the thermal shift assay easily identifies conditions that significantly enhance the stability of recombinant proteins. The same approach can be used as an initial low-cost screen to discover new protein-ligand interactions by capitalizing on increases in protein stability that typically occur upon ligand binding. This unit presents a methodological workflow for small-scale, high-throughput thermal denaturation of recombinant proteins in the presence of SYPRO Orange dye. Copyright © 2015 John Wiley & Sons, Inc.

  15. The application of a shift theorem analysis technique to multipoint measurements

    M. E. Dieckmann

    Full Text Available A Fourier domain technique has been proposed previously which, in principle, quantifies the extent to which multipoint in-situ measurements can identify whether or not an observed structure is time stationary in its rest frame. Once a structure, sampled for example by four spacecraft, is shown to be quasi-stationary in its rest frame, the structure's velocity vector can be determined with respect to the sampling spacecraft. We investigate the properties of this technique, which we will refer to as a stationarity test, by applying it to two point measurements of a simulated boundary layer. The boundary layer was evolved using a PIC (particle in cell electromagnetic code. Initial and boundary conditions were chosen such, that two cases could be considered, i.e. a spacecraft pair moving through (1 a time stationary boundary structure and (2 a boundary structure which is evolving (expanding in time. The code also introduces noise in the simulated data time series which is uncorrelated between the two spacecraft. We demonstrate that, provided that the time series is Hanning windowed, the test is effective in determining the relative velocity between the boundary layer and spacecraft and in determining the range of frequencies over which the data can be treated as time stationary or time evolving. This work presents a first step towards understanding the effectiveness of this technique, as required in order for it to be applied to multispacecraft data.

    Key words. Electromagnetics (wave propagation · Radio science (waves in plasma · Space plasma physics (active perturbation experiments.

  16. The application of a shift theorem analysis technique to multipoint measurements

    M. E. Dieckmann

    1999-03-01

    Full Text Available A Fourier domain technique has been proposed previously which, in principle, quantifies the extent to which multipoint in-situ measurements can identify whether or not an observed structure is time stationary in its rest frame. Once a structure, sampled for example by four spacecraft, is shown to be quasi-stationary in its rest frame, the structure's velocity vector can be determined with respect to the sampling spacecraft. We investigate the properties of this technique, which we will refer to as a stationarity test, by applying it to two point measurements of a simulated boundary layer. The boundary layer was evolved using a PIC (particle in cell electromagnetic code. Initial and boundary conditions were chosen such, that two cases could be considered, i.e. a spacecraft pair moving through (1 a time stationary boundary structure and (2 a boundary structure which is evolving (expanding in time. The code also introduces noise in the simulated data time series which is uncorrelated between the two spacecraft. We demonstrate that, provided that the time series is Hanning windowed, the test is effective in determining the relative velocity between the boundary layer and spacecraft and in determining the range of frequencies over which the data can be treated as time stationary or time evolving. This work presents a first step towards understanding the effectiveness of this technique, as required in order for it to be applied to multispacecraft data.Key words. Electromagnetics (wave propagation · Radio science (waves in plasma · Space plasma physics (active perturbation experiments.

  17. Formulation of nonlinear chromaticity in circular accelerators by canonical perturbation method

    Takao, Masaru

    2005-01-01

    The formulation of nonlinear chromaticity in circular accelerators based on the canonical perturbation method is presented. Since the canonical perturbation method directly relates the tune shift to the perturbation Hamiltonian, it greatly simplifies the calculation of the nonlinear chromaticity. The obtained integral representation for nonlinear chromaticity can be systematically extended to higher orders

  18. Perturbative studies of toroidal momentum transport using neutral beam injection modulation in the Joint European Torus: Experimental results, analysis methodology, and first principles modeling

    Mantica, P.; Tala, T.; Ferreira, J.S.

    2010-01-01

    Perturbative experiments have been carried out in the Joint European Torus [Fusion Sci. Technol. 53(4) (2008)] in order to identify the diffusive and convective components of toroidal momentum transport. The torque source was modulated either by modulating tangential neutral beam power...... or by modulating in antiphase tangential and normal beams to produce a torque perturbation in the absence of a power perturbation. The resulting periodic perturbation in the toroidal rotation velocity was modeled using time-dependent transport simulations in order to extract empirical profiles of momentum...

  19. Perturbation analysis of cyclotron resonance in the electromagnetic field of a TE{sub 011} mode; Analyse par perturbation de la resonance cyclotronique dans le champ electromagnetique en mode TE{sub 011} mode

    Dreicer, H [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1968-07-01

    The motion of an electron orbiting under the combined action of a static magnetic field and the AC azimuthal electric field of a cylindrical TE{sub 011} mode is analyzed with help of a perturbation technique. The first and second order perturbation results indicate that at cyclotron resonance the electron's center of gyration oscillates slowly at right angles to the magnetic field between two turning points. We find that superimposed upon this nearly static Exb drift the electron cyclically undergoes the process of cyclotron absorption and induced emission. Our results indicate that it is possible to insure maser action (i.e. induced emission rather than absorption) without special preparation of the electron's velocity provided that the electron is introduced into the field in certain special regions of space pervaded by the TE mode. This is a case where over-population of the upper state is accomplished through 'pumping' in real space. The relation between an electron cyclotron resonance maser based upon this principle and one based upon the principle of velocity space pumping, due to Twiss, is examined. This treatment provides physical interpretations and verifies the numerical results found earlier by Le Gardeur. (author) [French] Le mouvement d'un electron soumis a l'action combinee d'un champ magnetique statique et d'un champ electrique haute frequence azimutal engendre dans une cavite cylindrique en mode TE{sub 011} est analyse a partir d'une methode de perturbation. Les resultats des perturbations au premier et deuxieme ordre indiquent qu'a la resonance cyclotronique, le centre de giration de l'electron oscille lentement dans le plan perpendiculaire au champ magnetique entre deux points de rebroussement. En plus de la derivee quasi-statique ExB, l'electron passe par des etats d'absorption et emission cyclotronique. Les resultats du calcul confirment la possibilite d'avoir une action maser (c'est-a-dire: emission au lieu d'absorption) sans que la vitesse des

  20. Analysis on shift and rotation of intraocular lens after phakic collamer lens implantation

    Yuan-Yuan Lu

    2016-05-01

    Full Text Available Recently, the incidence of myopia increases year by year. The effectiveness of refractive surgery for the correction of ametropia is widely recognized with rapid development of ophthalmic microsurgery. The laser in situ keratomileusis(LASIKhas been accepted as a regular refractive surgery technique to correct mild and moderate myopia. However, it shows inadequacy in ability to correct high refractive errors, and in patients with thin cornea and keratoconus. In 1993, Staar Surgical(A.G. Nidauintroduced a modified intraocular collamer lens(ICLfor the correction of high myopia, which emerged as a safe and effective operation for moderate or high myopia gradually. Although it has already been proved that ICL has safety and efficacy for the correction of high myopia, several studies reported dislocation and rotation of ICL after implantation, which led decreased vision and poor satisfaction. In severe cases, secondary glaucoma, anterior subcapsular cataract happened consequentially. These potential complications have drawn more and more attention by the majority of physicians and scholars. This paper aims to discuss the potential cause of shift and rotation of ICLs after implantation.

  1. Resolution of ambiguities in perturbative QCD

    Nakkagawa, Hisao; Niegawa, Akira.

    1984-01-01

    In the perturbative QCD analyses of the deeply inelastic processes, the coupling constant depends on at least two mass-scales, the renormalization scale and the factorization scale. By integrating the coupled renormalization group equations with respect to these two mass-scales, the running coupling constant is defined. A perturbative approximation then introduces a new ambiguity, the integration-path dependence, into the theory. We show that the problem of this new ambiguity is resolved by imposing Stevenson's principle of minimal sensitivity. Together with the analogous analysis of the operator matrix element or the cut vertex, we can completely solve the problem of getting an unambiguous perturbative QCD prediction. (author)

  2. Mass generation in perturbed massless integrable models

    Controzzi, D.; Mussardo, G.

    2005-01-01

    We extend form-factor perturbation theory to non-integrable deformations of massless integrable models, in order to address the problem of mass generation in such systems. With respect to the standard renormalisation group analysis this approach is more suitable for studying the particle content of the perturbed theory. Analogously to the massive case, interesting information can be obtained already at first order, such as the identification of the operators which create a mass gap and those which induce the confinement of the massless particles in the perturbed theory

  3. Shifting from region of interest (ROI) to voxel-based analysis in human brain mapping

    Astrakas, Loukas G.; Argyropoulou, Maria I.

    2010-01-01

    Current clinical studies involve multidimensional high-resolution images containing an overwhelming amount of structural and functional information. The analysis of such a wealth of information is becoming increasingly difficult yet necessary in order to improve diagnosis, treatment and healthcare. Voxel-wise analysis is a class of modern methods of image processing in the medical field with increased popularity. It has replaced manual region of interest (ROI) analysis and has provided tools to make statistical inferences at voxel level. The introduction of voxel-based analysis software in all modern commercial scanners allows clinical use of these techniques. This review will explain the main principles, advantages and disadvantages behind these methods of image analysis. (orig.)

  4. Selecting the optimal anti-aliasing filter for multichannel biosignal acquisition intended for inter-signal phase shift analysis

    Keresnyei, Róbert; Hejjel, László; Megyeri, Péter; Zidarics, Zoltán

    2015-01-01

    The availability of microcomputer-based portable devices facilitates the high-volume multichannel biosignal acquisition and the analysis of their instantaneous oscillations and inter-signal temporal correlations. These new, non-invasively obtained parameters can have considerable prognostic or diagnostic roles. The present study investigates the inherent signal delay of the obligatory anti-aliasing filters. One cycle of each of the 8 electrocardiogram (ECG) and 4 photoplethysmogram signals from healthy volunteers or artificially synthesised series were passed through 100–80–60–40–20 Hz 2–4–6–8th order Bessel and Butterworth filters digitally synthesized by bilinear transformation, that resulted in a negligible error in signal delay compared to the mathematical model of the impulse- and step responses of the filters. The investigated filters have as diverse a signal delay as 2–46 ms depending on the filter parameters and the signal slew rate, which is difficult to predict in biological systems and thus difficult to compensate for. Its magnitude can be comparable to the examined phase shifts, deteriorating the accuracy of the measurement. As a conclusion, identical or very similar anti-aliasing filters with lower orders and higher corner frequencies, oversampling, and digital low pass filtering are recommended for biosignal acquisition intended for inter-signal phase shift analysis. (note)

  5. Dynamic metabolic flux analysis using B-splines to study the effects of temperature shift on CHO cell metabolism

    Verónica S. Martínez

    2015-12-01

    Full Text Available Metabolic flux analysis (MFA is widely used to estimate intracellular fluxes. Conventional MFA, however, is limited to continuous cultures and the mid-exponential growth phase of batch cultures. Dynamic MFA (DMFA has emerged to characterize time-resolved metabolic fluxes for the entire culture period. Here, the linear DMFA approach was extended using B-spline fitting (B-DMFA to estimate mass balanced fluxes. Smoother fits were achieved using reduced number of knots and parameters. Additionally, computation time was greatly reduced using a new heuristic algorithm for knot placement. B-DMFA revealed that Chinese hamster ovary cells shifted from 37 °C to 32 °C maintained a constant IgG volume-specific productivity, whereas the productivity for the controls peaked during mid-exponential growth phase and declined afterward. The observed 42% increase in product titer at 32 °C was explained by a prolonged cell growth with high cell viability, a larger cell volume and a more stable volume-specific productivity. Keywords: Dynamic, Metabolism, Flux analysis, CHO cells, Temperature shift, B-spline curve fitting

  6. Numerical analysis of the shifting slabs applied in a wireless power transfer system to enhance magnetic coupling

    Yayun Dong

    2017-05-01

    Full Text Available Shifting medium is a kind of metamaterial, which can optically shift a space or an object a certain distance away from its original position. Based on the shifting medium, we propose a concise pair of shifting slabs covering the transmitting or receiving coil in a two-coil wireless power transfer system to decrease the equivalent distance between the coils. The electromagnetic parameters of the shifting slabs are calculated by transformation optics. Numerical simulations validate that the shifting slabs can approximately shift the electromagnetic fields generated by the covered coil; thus, the magnetic coupling and the efficiency of the system are enhanced while remaining the physical transmission distance unchanged. We also verify the advantages of the shifting slabs over the magnetic superlens. Finally, we provide two methods to fabricate shifting slabs based on split-ring resonators.

  7. Numerical analysis of the shifting slabs applied in a wireless power transfer system to enhance magnetic coupling

    Dong, Yayun; Yang, Xijun; Jin, Nan; Li, Wenwen; Yao, Chen; Tang, Houjun

    2017-05-01

    Shifting medium is a kind of metamaterial, which can optically shift a space or an object a certain distance away from its original position. Based on the shifting medium, we propose a concise pair of shifting slabs covering the transmitting or receiving coil in a two-coil wireless power transfer system to decrease the equivalent distance between the coils. The electromagnetic parameters of the shifting slabs are calculated by transformation optics. Numerical simulations validate that the shifting slabs can approximately shift the electromagnetic fields generated by the covered coil; thus, the magnetic coupling and the efficiency of the system are enhanced while remaining the physical transmission distance unchanged. We also verify the advantages of the shifting slabs over the magnetic superlens. Finally, we provide two methods to fabricate shifting slabs based on split-ring resonators.

  8. Chiral perturbation theory

    Ecker, G.

    1996-06-01

    After a general introduction to the structure of effective field theories, the main ingredients of chiral perturbation theory are reviewed. Applications include the light quark mass ratios and pion-pion scattering to two-loop accuracy. In the pion-nucleon system, the linear σ model is contrasted with chiral perturbation theory. The heavy-nucleon expansion is used to construct the effective pion-nucleon Lagrangian to third order in the low-energy expansion, with applications to nucleon Compton scattering. (author)

  9. Testing peat humification analysis in an Australian context: identifying wet shifts in regional climate over the past 4000 years

    M.A. Burrows

    2014-08-01

    Full Text Available Peat humification analysis is presented as a robust palaeoclimatic proxy, suitable for use on mid–late Holocene peat sequences situated in the Southern Hemisphere. The proxy is shown to permit the identification of wet and dry shifts in a peat sequence from the humid tropics of north-eastern Australia. A significant correlation is found between the humification record and other proxies indicative of past climate conditions such as pollen, δ13C, C/N and macrocharcoal. Sixteen wet shifts detected in the humification record for Bromfield Swamp occur at the following dates (with 2σ range: 3830 (3920–3740, 3560 (3640–3480, 3490 (3560–3420, 3380 (3450–3300, 3120 (3250–2970, 2950 (3100–2790, 2560 (2710–2450, 2430 (2600–2260, 2120 (2330–1910, 1750 (1980–1520, 1430 (1660–1200, 1170 (1390–960, 1010 (1220–820, 620 (770–500, 300 (400–200 and 100 (200–10 cal. yr BP. Eleven dry shifts are also identified in the record at 4220 (4330–4110, 3670 (3750–3590, 3330 (3420–3220, 3020 (3170–2870, 2350 (2530–2160, 2020 (2230–1800, 1730 (1980–1510, 1290 (1510–1070, 700 (870–560, 400 (470–300 and 260 (360–150 cal yr BP. Blechnum and Poaceae are identified by pollen analysis to be the dominant plants of the swamp surface over the past 4000 years. The ratio of these two plant taxa in the pollen record correlates well with identified wet and dry shifts. It is suggested that a ratio ≤1 possibly indicates dry conditions, a ratio of >1–3 indicates wet or dry conditions, and a ratio >3 implies wet conditions. Large macrocharcoal peaks are recorded during the initiation phase of the peat sequence at approximately 4090 cal. yr BP, and at 3700–3620 cal. yr BP, both of these time periods being coincident with dry phases. Isolated minor macrocharcoal peaks at ca. 2860, 2820, 2620, 2560, 2130, 1930, 1740 and 200 cal. yr BP are found to coincide with periods of average effective precipitation (based on the humification

  10. Multi-source analysis reveals latitudinal and altitudinal shifts in range of Ixodes ricinus at its northern distribution limit

    Kristoffersen Anja B

    2011-05-01

    Full Text Available Abstract Background There is increasing evidence for a latitudinal and altitudinal shift in the distribution range of Ixodes ricinus. The reported incidence of tick-borne disease in humans is on the rise in many European countries and has raised political concern and attracted media attention. It is disputed which factors are responsible for these trends, though many ascribe shifts in distribution range to climate changes. Any possible climate effect would be most easily noticeable close to the tick's geographical distribution limits. In Norway- being the northern limit of this species in Europe- no documentation of changes in range has been published. The objectives of this study were to describe the distribution of I. ricinus in Norway and to evaluate if any range shifts have occurred relative to historical descriptions. Methods Multiple data sources - such as tick-sighting reports from veterinarians, hunters, and the general public - and surveillance of human and animal tick-borne diseases were compared to describe the present distribution of I. ricinus in Norway. Correlation between data sources and visual comparison of maps revealed spatial consistency. In order to identify the main spatial pattern of tick abundance, a principal component analysis (PCA was used to obtain a weighted mean of four data sources. The weighted mean explained 67% of the variation of the data sources covering Norway's 430 municipalities and was used to depict the present distribution of I. ricinus. To evaluate if any geographical range shift has occurred in recent decades, the present distribution was compared to historical data from 1943 and 1983. Results Tick-borne disease and/or observations of I. ricinus was reported in municipalities up to an altitude of 583 metres above sea level (MASL and is now present in coastal municipalities north to approximately 69°N. Conclusion I. ricinus is currently found further north and at higher altitudes than described in

  11. Thermoelastic analysis of non-uniform pressurized functionally graded cylinder with variable thickness using first order shear deformation theory(FSDT) and perturbation method

    Khoshgoftar, M. J.; Mirzaali, M. J.; Rahimi, G. H.

    2015-11-01

    Recently application of functionally graded materials(FGMs) have attracted a great deal of interest. These materials are composed of various materials with different micro-structures which can vary spatially in FGMs. Such composites with varying thickness and non-uniform pressure can be used in the aerospace engineering. Therefore, analysis of such composite is of high importance in engineering problems. Thermoelastic analysis of functionally graded cylinder with variable thickness under non-uniform pressure is considered. First order shear deformation theory and total potential energy approach is applied to obtain the governing equations of non-homogeneous cylinder. Considering the inner and outer solutions, perturbation series are applied to solve the governing equations. Outer solution for out of boundaries and more sensitive variable in inner solution at the boundaries are considered. Combining of inner and outer solution for near and far points from boundaries leads to high accurate displacement field distribution. The main aim of this paper is to show the capability of matched asymptotic solution for different non-homogeneous cylinders with different shapes and different non-uniform pressures. The results can be used to design the optimum thickness of the cylinder and also some properties such as high temperature residence by applying non-homogeneous material.

  12. Parameter Identification with the Random Perturbation Particle Swarm Optimization Method and Sensitivity Analysis of an Advanced Pressurized Water Reactor Nuclear Power Plant Model for Power Systems

    Li Wang

    2017-02-01

    Full Text Available The ability to obtain appropriate parameters for an advanced pressurized water reactor (PWR unit model is of great significance for power system analysis. The attributes of that ability include the following: nonlinear relationships, long transition time, intercoupled parameters and difficult obtainment from practical test, posed complexity and difficult parameter identification. In this paper, a model and a parameter identification method for the PWR primary loop system were investigated. A parameter identification process was proposed, using a particle swarm optimization (PSO algorithm that is based on random perturbation (RP-PSO. The identification process included model variable initialization based on the differential equations of each sub-module and program setting method, parameter obtainment through sub-module identification in the Matlab/Simulink Software (Math Works Inc., Natick, MA, USA as well as adaptation analysis for an integrated model. A lot of parameter identification work was carried out, the results of which verified the effectiveness of the method. It was found that the change of some parameters, like the fuel temperature and coolant temperature feedback coefficients, changed the model gain, of which the trajectory sensitivities were not zero. Thus, obtaining their appropriate values had significant effects on the simulation results. The trajectory sensitivities of some parameters in the core neutron dynamic module were interrelated, causing the parameters to be difficult to identify. The model parameter sensitivity could be different, which would be influenced by the model input conditions, reflecting the parameter identifiability difficulty degree for various input conditions.

  13. Resummation of divergent perturbation series: Application to the vibrational states of H2CO molecule.

    Duchko, A N; Bykov, A D

    2015-10-21

    Large-order Rayleigh-Schrödinger perturbation theory (RSPT) is applied to the calculation of anharmonic vibrational energy levels of H2CO molecule. We use the model of harmonic oscillators perturbed by anharmonic terms of potential energy. Since the perturbation series typically diverge due to strong couplings, we apply the algebraic approximation technique because of its effectiveness shown earlier by Goodson and Sergeev [J. Chem. Phys. 110, 8205 (1999); ibid. 124, 094111 (2006)] and in our previous articles [A. D. Bykov et al. Opt. Spectrosc. 114, 396 (2013); ibid. 116, 598 (2014)]. To facilitate the resummation of terms contributing to perturbed states, when resonance mixing between states is especially strong and perturbation series diverge very quick, we used repartition of the Hamiltonian by shifting the normal mode frequencies. Energy levels obtained by algebraic approximants were compared with the results of variational calculation. It was found that for low energy states (up to ∼5000 cm(-1)), algebraic approximants gave accurate values of energy levels, which were in excellent agreement with the variational method. For highly excited states, strong and multiple resonances complicate series resummation, but a suitable change of normal mode frequencies allows one to reduce the resonance mixing and to get accurate energy levels. The theoretical background of the problem of RSPT series divergence is discussed along with its numerical analysis. For these purposes, the vibrational energy is considered as a function of a complex perturbation parameter. Layout and classification of its singularities allow us to model the asymptotic behavior of the perturbation series and prove the robustness of the algorithm.

  14. Resummation of divergent perturbation series: Application to the vibrational states of H2CO molecule

    Duchko, A. N.; Bykov, A. D.

    2015-01-01

    Large-order Rayleigh–Schrödinger perturbation theory (RSPT) is applied to the calculation of anharmonic vibrational energy levels of H 2 CO molecule. We use the model of harmonic oscillators perturbed by anharmonic terms of potential energy. Since the perturbation series typically diverge due to strong couplings, we apply the algebraic approximation technique because of its effectiveness shown earlier by Goodson and Sergeev [J. Chem. Phys. 110, 8205 (1999); ibid. 124, 094111 (2006)] and in our previous articles [A. D. Bykov et al. Opt. Spectrosc. 114, 396 (2013); ibid. 116, 598 (2014)]. To facilitate the resummation of terms contributing to perturbed states, when resonance mixing between states is especially strong and perturbation series diverge very quick, we used repartition of the Hamiltonian by shifting the normal mode frequencies. Energy levels obtained by algebraic approximants were compared with the results of variational calculation. It was found that for low energy states (up to ∼5000 cm −1 ), algebraic approximants gave accurate values of energy levels, which were in excellent agreement with the variational method. For highly excited states, strong and multiple resonances complicate series resummation, but a suitable change of normal mode frequencies allows one to reduce the resonance mixing and to get accurate energy levels. The theoretical background of the problem of RSPT series divergence is discussed along with its numerical analysis. For these purposes, the vibrational energy is considered as a function of a complex perturbation parameter. Layout and classification of its singularities allow us to model the asymptotic behavior of the perturbation series and prove the robustness of the algorithm

  15. Digital tomosynthesis parallel imaging computational analysis with shift and add and back projection reconstruction algorithms.

    Chen, Ying; Balla, Apuroop; Rayford II, Cleveland E; Zhou, Weihua; Fang, Jian; Cong, Linlin

    2010-01-01

    Digital tomosynthesis is a novel technology that has been developed for various clinical applications. Parallel imaging configuration is utilised in a few tomosynthesis imaging areas such as digital chest tomosynthesis. Recently, parallel imaging configuration for breast tomosynthesis began to appear too. In this paper, we present the investigation on computational analysis of impulse response characterisation as the start point of our important research efforts to optimise the parallel imaging configurations. Results suggest that impulse response computational analysis is an effective method to compare and optimise imaging configurations.

  16. Preheating curvaton perturbations

    Bastero-Gil, M.; Di Clemente, V.; King, S.F.

    2005-01-01

    We discuss the potentially important role played by preheating in certain variants of the curvaton mechanism in which isocurvature perturbations of a D-flat (and F-flat) direction become converted to curvature perturbations during reheating. We discover that parametric resonance of the isocurvature components amplifies the superhorizon fluctuations by a significant amount. As an example of these effects we develop a particle physics motivated model which involves hybrid inflation with the waterfall field N being responsible for generating the μ term, the right-handed neutrino mass scale, and the Peccei-Quinn symmetry breaking scale. The role of the curvaton field can be played either by usual Higgs field, or the lightest right-handed sneutrino. Our new results show that it is possible to achieve the correct curvature perturbations for initial values of the curvaton fields of order the weak scale. In this model we show that the prediction for the spectral index of the final curvature perturbation only depends on the mass of the curvaton during inflation, where consistency with current observational data requires the ratio of this mass to the Hubble constant to be 0.3

  17. String perturbation theory diverges

    Gross, D.J.; Periwal, V.

    1988-01-01

    We prove that perturbation theory for the bosonic string diverges for arbitrary values of the coupling constant and is not Borel summable. This divergence is independent of the existence of the infinities that occur in the theory due to the presence of tachyons and dilaton tadpoles. We discuss the physical implications of such a divergence

  18. Divergent Perturbation Series

    Suslov, I.M.

    2005-01-01

    Various perturbation series are factorially divergent. The behavior of their high-order terms can be determined by Lipatov's method, which involves the use of instanton configurations of appropriate functional integrals. When the Lipatov asymptotic form is known and several lowest order terms of the perturbation series are found by direct calculation of diagrams, one can gain insight into the behavior of the remaining terms of the series, which can be resummed to solve various strong-coupling problems in a certain approximation. This approach is demonstrated by determining the Gell-Mann-Low functions in φ 4 theory, QED, and QCD with arbitrary coupling constants. An overview of the mathematical theory of divergent series is presented, and interpretation of perturbation series is discussed. Explicit derivations of the Lipatov asymptotic form are presented for some basic problems in theoretical physics. A solution is proposed to the problem of renormalon contributions, which hampered progress in this field in the late 1970s. Practical perturbation-series summation schemes are described both for a coupling constant of order unity and in the strong-coupling limit. An interpretation of the Borel integral is given for 'non-Borel-summable' series. Higher order corrections to the Lipatov asymptotic form are discussed

  19. Instantaneous stochastic perturbation theory

    Lüscher, Martin

    2015-01-01

    A form of stochastic perturbation theory is described, where the representative stochastic fields are generated instantaneously rather than through a Markov process. The correctness of the procedure is established to all orders of the expansion and for a wide class of field theories that includes all common formulations of lattice QCD.

  20. Scalar cosmological perturbations

    Uggla, Claes; Wainwright, John

    2012-01-01

    Scalar perturbations of Friedmann-Lemaitre cosmologies can be analyzed in a variety of ways using Einstein's field equations, the Ricci and Bianchi identities, or the conservation equations for the stress-energy tensor, and possibly introducing a timelike reference congruence. The common ground is the use of gauge invariants derived from the metric tensor, the stress-energy tensor, or from vectors associated with a reference congruence, as basic variables. Although there is a complication in that there is no unique choice of gauge invariants, we will show that this can be used to advantage. With this in mind our first goal is to present an efficient way of constructing dimensionless gauge invariants associated with the tensors that are involved, and of determining their inter-relationships. Our second goal is to give a unified treatment of the various ways of writing the governing equations in dimensionless form using gauge-invariant variables, showing how simplicity can be achieved by a suitable choice of variables and normalization factors. Our third goal is to elucidate the connection between the metric-based approach and the so-called 1 + 3 gauge-invariant approach to cosmological perturbations. We restrict our considerations to linear perturbations, but our intent is to set the stage for the extension to second-order perturbations. (paper)

  1. Generalized perturbation series

    Baird, L.C.; Stinchcomb, G.

    1973-01-01

    An approximate solution of the Green's function equation may be used to generate an exact solution of the Schroedinger equation. This is accomplished through an iterative procedure. The procedure is equivalent to a perturbation expansion if the approximate Green's function is exact with respect to some reference potential

  2. Perturbed S3 neutrinos

    jora, Renata; Schechter, Joseph; Naeem Shahid, M.

    2009-01-01

    We study the effects of the perturbation which violates the permutation symmetry of three Majorana neutrinos but preserves the well known (23) interchange symmetry. This is done in the presenceof an arbitrary Majorana phase which serves to insure the degeneracy of the three neutrinos at the unper...... at the unperturbed level....

  3. Shifting the Focus: Children's Image-Making Practices and Their Implications for Analysis

    Lomax, Helen Jayne

    2012-01-01

    This paper provides analytic focus on the productive and editorial contexts of children and young people's image-making, making visible its implications for the analysis of photographs. Drawing on participatory research in which children and young people worked alongside researchers to create a visual narrative of their lived experiences of…

  4. Structural-change localization and monitoring through a perturbation-based inverse problem.

    Roux, Philippe; Guéguen, Philippe; Baillet, Laurent; Hamze, Alaa

    2014-11-01

    Structural-change detection and characterization, or structural-health monitoring, is generally based on modal analysis, for detection, localization, and quantification of changes in structure. Classical methods combine both variations in frequencies and mode shapes, which require accurate and spatially distributed measurements. In this study, the detection and localization of a local perturbation are assessed by analysis of frequency changes (in the fundamental mode and overtones) that are combined with a perturbation-based linear inverse method and a deconvolution process. This perturbation method is applied first to a bending beam with the change considered as a local perturbation of the Young's modulus, using a one-dimensional finite-element model for modal analysis. Localization is successful, even for extended and multiple changes. In a second step, the method is numerically tested under ambient-noise vibration from the beam support with local changes that are shifted step by step along the beam. The frequency values are revealed using the random decrement technique that is applied to the time-evolving vibrations recorded by one sensor at the free extremity of the beam. Finally, the inversion method is experimentally demonstrated at the laboratory scale with data recorded at the free end of a Plexiglas beam attached to a metallic support.

  5. Modelling and analysis of a novel compressed air energy storage system for trigeneration based on electrical energy peak load shifting

    Lv, Song; He, Wei; Zhang, Aifeng; Li, Guiqiang; Luo, Bingqing; Liu, Xianghua

    2017-01-01

    Highlights: • A new CAES system for trigeneration based on electrical peak load shifting is proposed. • The theoretical models and the thermodynamics process are established and analyzed. • The relevant parameters influencing its performance have been discussed and optimized. • A novel energy and economic evaluation methods is proposed to evaluate the performance of the system. - Abstract: The compressed air energy storage (CAES) has made great contribution to both electricity and renewable energy. In the pursuit of reduced energy consumption and relieving power utility pressure effectively, a novel trigeneration system based on CAES for cooling, heating and electricity generation by electrical energy peak load shifting is proposed in this paper. The cooling power is generated by the direct expansion of compressed air, and the heating power is recovered in the process of compression and storage. Based on the working principle of the typical CAES, the theoretical analysis of the thermodynamic system models are established and the characteristics of the system are analyzed. A novel method used to evaluate energy and economic performance is proposed. A case study is conducted, and the economic-social and technical feasibility of the proposed system are discussed. The results show that the trigeneration system works efficiently at relatively low pressure, and the efficiency is expected to reach about 76.3% when air is compressed and released by 15 bar. The annual monetary cost saving annually is about 53.9%. Moreover, general considerations about the proposed system are also presented.

  6. Phase shift analysis of pion-nucleon elastic scattering from the threshold to 2.5 GeV

    Ayed, Rachid.

    1976-10-01

    An energy-independent phase-shift analysis of pion-nucleon elastic scattering is performed from threshold to 2.5 GeV/c 2 masses. It uses a coherent set of data (cross sections and polarizations for the 3 final states: π + p, π - p and π 0 n) constructed from a considerable number (approximately 30000) of experimental points. Empirical criteria of smoothness behavior with energy of the partial waves allowed to obtain a unique solution, i.e. one set of phases shifts (up to I waves) at each energy. The consistency of the solution has been checked by a dispersion relation on the B invariant amplitude. The partial amplitudes obtained have been fitted separately, as a function of energy, in order to extract resonance from background. New resonances of small elasticity have been identified. Parameters (mass, width and elasticity) of all resonant states are given. A dynamical interpretation of the resonance is discussed and their recurrence in the Chew-Frautschi plot are shown [fr

  7. Shifting chronic disease management from hospitals to primary care in Estonian health system: analysis of national panel data.

    Atun, Rifat; Gurol-Urganci, Ipek; Hone, Thomas; Pell, Lisa; Stokes, Jonathan; Habicht, Triin; Lukka, Kaija; Raaper, Elin; Habicht, Jarno

    2016-12-01

    Following independence from the Soviet Union in 1991, Estonia introduced a national insurance system, consolidated the number of health care providers, and introduced family medicine centred primary health care (PHC) to strengthen the health system. Using routinely collected health billing records for 2005-2012, we examine health system utilisation for seven ambulatory care sensitive conditions (ACSCs) (asthma, chronic obstructive pulmonary disease [COPD], depression, Type 2 diabetes, heart failure, hypertension, and ischemic heart disease [IHD]), and by patient characteristics (gender, age, and number of co-morbidities). The data set contained 552 822 individuals. We use patient level data to test the significance of trends, and employ multivariate regression analysis to evaluate the probability of inpatient admission while controlling for patient characteristics, health system supply-side variables, and PHC use. Over the study period, utilisation of PHC increased, whilst inpatient admissions fell. Service mix in PHC changed with increases in phone, email, nurse, and follow-up (vs initial) consultations. Healthcare utilisation for diabetes, depression, IHD and hypertension shifted to PHC, whilst for COPD, heart failure and asthma utilisation in outpatient and inpatient settings increased. Multivariate regression indicates higher probability of inpatient admission for males, older patient and especially those with multimorbidity, but protective effect for PHC, with significantly lower hospital admission for those utilising PHC services. Our findings suggest health system reforms in Estonia have influenced the shift of ACSCs from secondary to primary care, with PHC having a protective effect in reducing hospital admissions.

  8. Analysis of Power System Low Frequency Oscillation Based on Energy Shift Theory

    Zhang, Junfeng; Zhang, Chunwang; Ma, Daqing

    2018-01-01

    In this paper, a new method for analyzing low-frequency oscillation between analytic areas based on energy coefficient is proposed. The concept of energy coefficient is proposed by constructing the energy function, and the low-frequency oscillation is analyzed according to the energy coefficient under the current operating conditions; meanwhile, the concept of model energy is proposed to analyze the energy exchange behavior between two generators. Not only does this method provide an explanation of low-frequency oscillation from the energy point of view, but also it helps further reveal the dynamic behavior of complex power systems. The case analysis of four-machine two-area and the power system of Jilin Power Grid proves the correctness and effectiveness of the proposed method in low-frequency oscillation analysis of power system.

  9. Output synchronization of chaotic systems under nonvanishing perturbations

    Lopez-Mancilla, Didier [Departamento de Ciencias Exactas y Tecnologicas, Centro Universitario de los Lagos, Universidad de Guadalajara (CULagos-UdeG), Enrique Diaz de Leon s/n, 47460 Lagos de Moreno, Jal. (Mexico)], E-mail: didier@uabc.mx; Cruz-Hernandez, Cesar [Electronics and Telecommunications Department, Scientific Research and Advanced Studies of Ensenada (CICESE), Km. 107, Carretera Tijuana-Ensenada, 22860 Ensenada, B.C. (Mexico)], E-mail: ccruz@cicese.mx

    2008-08-15

    In this paper, an analysis for chaos synchronization under nonvanishing perturbations is presented. In particular, we use model-matching approach from nonlinear control theory for output synchronization of identical and nonidentical chaotic systems under nonvanishing perturbations in a master-slave configuration. We show that the proposed approach is indeed suitable to synchronize a class of perturbed slaves with a chaotic master system; that is the synchronization error trajectories remain bounded if the perturbations satisfy some conditions. In order to illustrate this robustness synchronization property, we present two cases of study: (i) for identical systems, a pair of coupled Roessler systems, the first like a master and the other like a perturbed slave, and (ii) for nonidentical systems, a Chua's circuit driving a Roessler/slave system with a perturbed control law, in both cases a quantitative analysis on the perturbation is included.

  10. Output synchronization of chaotic systems under nonvanishing perturbations

    Lopez-Mancilla, Didier; Cruz-Hernandez, Cesar

    2008-01-01

    In this paper, an analysis for chaos synchronization under nonvanishing perturbations is presented. In particular, we use model-matching approach from nonlinear control theory for output synchronization of identical and nonidentical chaotic systems under nonvanishing perturbations in a master-slave configuration. We show that the proposed approach is indeed suitable to synchronize a class of perturbed slaves with a chaotic master system; that is the synchronization error trajectories remain bounded if the perturbations satisfy some conditions. In order to illustrate this robustness synchronization property, we present two cases of study: (i) for identical systems, a pair of coupled Roessler systems, the first like a master and the other like a perturbed slave, and (ii) for nonidentical systems, a Chua's circuit driving a Roessler/slave system with a perturbed control law, in both cases a quantitative analysis on the perturbation is included

  11. On the resolvents methods in quantum perturbation calculations

    Burzynski, A.

    1979-01-01

    This paper gives a systematic review of resolvent methods in quantum perturbation calculations. The case of discrete spectrum of hamiltonian is considered specially (in the literature this is the fewest considered case). The topics of calculations of quantum transitions by using of the resolvent formalism, quantum transitions between states from particular subspaces, the shifts of energy levels, are shown. The main ideas of stationary perturbation theory developed by Lippmann and Schwinger are considered too. (author)

  12. Market shifting

    Forst, Michael

    2013-11-01

    After years of oversupply and artificially low module pricing, market analysts believe that the solar industry will begin to stabilize by 2017. While the market activities are shifting from Europe to the Asia Pacific region and the United States, the solar shakeout continues to be in full swing including solar cell and module manufacturing. (orig.)

  13. Tough Shift

    Brewer, Robert S.; Verdezoto, Nervo; Holst, Thomas

    2015-01-01

    people to change their behavior at home. Leveraging prior research on encouraging reductions in residential energy use through game play, we introduce ShareBuddy: a casual mobile game intended to encourage players not only to reduce, but also to shift their electricity use. We conducted two field studies...... real-world resource use into a game....

  14. Phase shift analysis of K anti Kπ system in the D and E/IOTA regions

    Chung, S.U.; Fernow, R.; Kirk, H.

    1985-01-01

    We have performed a high-statistics experiment on the reaction π - p → K + anti K 0 π - n at 8.0 GeV/c. A partial-wave analysis of the K + anti K 0 π - system finds that the D(1285) is mostly a J/sup PG/ = 1 ++ state coupling predominantly to a deltaπ decay channel, while the E(1420) peak consists mostly of a J/sup PG/ = 0 -+ wave with a substantial deltaπ decay mode. There is little evidence of a 1 ++ resonance at the E mass. 10 refs., 3 figs

  15. Modified potentials in many-body perturbation theory

    Silver, D.M.; Bartlett, R.J.

    1976-01-01

    Many-body perturbation-theory calculations of the pair-correlation energy within the regime of various finite expansions in two-center Slater-type basis sets are performed using a wide variety of modified potentials for the determination of unoccupied orbitals. To achieve meaningful convergence, it appears that the perturbation series must be carried through third order, using shifted denominators to include contributions from various higher-order diagrams. Moreover, certain denominator shifts are found necessary to ensure that a negative-definite resolvent accompanies the perturbation scheme when an arbitrary modified potential is employed. Through third order with denominator shifts, well-behaved modified potentials are found to give results that are equivalent, within 1 kcal/mole, to those obtained for pair-correlation energies with the standard self-consistent-field-V/sup N/ potential

  16. Identification of squid species by melting temperature shifts on fluorescence melting curve analysis (FMCA) using single dual-labeled probe

    Koh, Eunjung; Song, Ha Jeong; Kwon, Na Young; Kim, Gi Won; Lee, Kwang Ho; Jo, Soyeon; Park, Sujin; Park, Jihyun; Park, Eun Kyeong; Hwang, Seung Yong

    2017-06-01

    Real time PCR is a standard method for identification of species. One of limitations of the qPCR is that there would be false-positive result due to mismatched hybridization between target sequence and probe depending on the annealing temperature in the PCR condition. As an alternative, fluorescence melting curve analysis (FMCA) could be applied for species identification. FMCA is based on a dual-labeled probe. Even with subtle difference of target sequence, there are visible melting temperature (Tm) shift. One of FMCA applications is distinguishing organisms distributed and consumed globally as popular food ingredients. Their prices are set by species or country of origin. However, counterfeiting or distributing them without any verification procedure are becoming social problems and threatening food safety. Besides distinguishing them in naked eye is very difficult and almost impossible in any processed form. Therefore, it is necessary to identify species in molecular level. In this research three species of squids which have 1-2 base pair differences each are selected as samples since they have the same issue. We designed a probe which perfectly matches with one species and the others mismatches 2 and 1 base pair respectively and labeled with fluorophore and quencher. In an experiment with a single probe, we successfully distinguished them by Tm shift depending on the difference of base pair. By combining FMCA and qPCR chip, smaller-scale assay with higher sensitivity and resolution could be possible, andc furthermore, enabling results analysis with smart phone would realize point-of-care testing (POCT).

  17. Dietary compositions and their seasonal shifts in Japanese resident birds, estimated from the analysis of volunteer monitoring data.

    Tetsuro Yoshikawa

    Full Text Available Determining the composition of a bird's diet and its seasonal shifts are fundamental for understanding the ecology and ecological functions of a species. Various methods have been used to estimate the dietary compositions of birds, which have their own advantages and disadvantages. In this study, we examined the possibility of using long-term volunteer monitoring data as the source of dietary information for 15 resident bird species in Kanagawa Prefecture, Japan. The data were collected from field observations reported by volunteers of regional naturalist groups. Based on these monitoring data, we calculated the monthly dietary composition of each bird species directly, and we also estimated unidentified items within the reported foraging episodes using Bayesian models that contained additional information regarding foraging locations. Next, to examine the validity of the estimated dietary compositions, we compared them with the dietary information for focal birds based on stomach analysis methods, collected from past literatures. The dietary trends estimated from the monitoring data were largely consistent with the general food habits determined from the previous studies of focal birds. Thus, the estimates based on the volunteer monitoring data successfully detected noticeable seasonal shifts in many of the birds from plant materials to animal diets during spring-summer. Comparisons with stomach analysis data supported the qualitative validity of the monitoring-based dietary information and the effectiveness of the Bayesian models for improving the estimates. This comparison suggests that one advantage of using monitoring data is its ability to detect dietary items such as fleshy fruits, flower nectar, and vertebrates. These results emphasize the potential importance of observation data collecting and mining by citizens, especially free descriptive observation data, for use in bird ecology studies.

  18. Studying the perturbative Reggeon

    Griffiths, S.; Ross, D.A.

    2000-01-01

    We consider the flavour non-singlet Reggeon within the context of perturbative QCD. This consists of ladders built out of ''reggeized'' quarks. We propose a method for the numerical solution of the integro-differential equation for the amplitude describing the exchange of such a Reggeon. The solution is known to have a sharp rise at low values of Bjorken-x when applied to non-singlet quantities in deep-inelastic scattering. We show that when the running of the coupling is taken into account this sharp rise is further enhanced, although the Q 2 dependence is suppressed by the introduction of the running coupling. We also investigate the effects of simulating non-perturbative physics by introducing a constituent mass for the soft quarks and an effective mass for the soft gluons exchanged in the t-channel. (orig.)

  19. Renormalized Lie perturbation theory

    Rosengaus, E.; Dewar, R.L.

    1981-07-01

    A Lie operator method for constructing action-angle transformations continuously connected to the identity is developed for area preserving mappings. By a simple change of variable from action to angular frequency a perturbation expansion is obtained in which the small denominators have been renormalized. The method is shown to lead to the same series as the Lagrangian perturbation method of Greene and Percival, which converges on KAM surfaces. The method is not superconvergent, but yields simple recursion relations which allow automatic algebraic manipulation techniques to be used to develop the series to high order. It is argued that the operator method can be justified by analytically continuing from the complex angular frequency plane onto the real line. The resulting picture is one where preserved primary KAM surfaces are continuously connected to one another

  20. Capital-Energy Substitution and Shifts in Factor Demand. A Meta-Analysis

    Koetse, M.J. [Department of Spatial Economics, Vrije Universiteit Amsterdam (Netherlands); De Groot, Henri L.F. [Tinbergen Institute, Amsterdam (Netherlands); Florax, R.J.G.M. [Department of Agricultural Economics, Purdue University, West Lafayette (United States)

    2006-07-01

    This paper presents results of a meta-regression analysis on empirical estimates of capital-energy substitution. Theoretically it is clear that a distinction should be made between Morishima substitution elasticities and cross-price elasticities. The former represent purely technical substitution possibilities while the latter include an income effect and therefore represent economic substitution potential. We estimate a meta-regression model with separate coefficients for the two elasticity samples. Our findings suggest that primary model assumptions on returns to scale, technological change and separability of input factors matter for the outcome of a primary study. Aggregation of variables and the type of data used in empirical research are also relevant sources of systematic effect-size variation. Taking these factors into consideration, we compute ideal-typical elasticities for the short, medium and long run. The resulting figures clearly show that substitution elasticities are substantially higher than cross price elasticities. Therefore, despite considerable technical opportunities for capital-energy substitution, they are almost entirely outweighed by the negative income effect brought about by energy price increases; the short and medium run cross price elasticities are not statistically different from zero. In the long run this pattern does not hold. Our findings therefore suggest that actual changes in the demand for capital due to energy price increases take time.

  1. Nonperturbative perturbation theory

    Bender, C.M.

    1989-01-01

    In this talk we describe a recently proposed graphical perturbative calculational scheme for quantum field theory. The basic idea is to expand in the power of the interaction term. For example, to solve a λφ 4 theory in d-dimensional space-time, we introduce a small parameter δ and consider a λ(φ 2 ) 1+δ field theory. We show how to expand such a theory as a series in powers of δ. The resulting perturbation series appears to have a finite radius of convergence and numerical results for low-dimensional models are good. We have computed the two-point and four-point Green's functions to second order in powers of δ and the 2n-point Green's functions (n>2) to order δ. We explain how to renormalize the theory and show that, to first order in powers of δ, when δ>0 and d≥4 the theory is free. This conclusion remains valid to second order in powers of δ, and we believe that it remains valid to all orders in powers of δ. The new perturbative scheme is consistent with global supersymmetry invariance. We examine a two-dimensional supersymmetric quantum field theory in which we do not know of any other means for doing analytical calculations. We illustrate the power of this new technique by computing the ground-state energy density E to second order in this new perturbation theory. We show that there is a beautiful and delicate cancellation between infinite classes of graphs which leads to the result that E=0. (orig.)

  2. Perturbed asymptotically linear problems

    Bartolo, R.; Candela, A. M.; Salvatore, A.

    2012-01-01

    The aim of this paper is investigating the existence of solutions of some semilinear elliptic problems on open bounded domains when the nonlinearity is subcritical and asymptotically linear at infinity and there is a perturbation term which is just continuous. Also in the case when the problem has not a variational structure, suitable procedures and estimates allow us to prove that the number of distinct crtitical levels of the functional associated to the unperturbed problem is "stable" unde...

  3. Twisting perturbed parafermions

    A.V. Belitsky

    2017-07-01

    Full Text Available The near-collinear expansion of scattering amplitudes in maximally supersymmetric Yang–Mills theory at strong coupling is governed by the dynamics of stings propagating on the five sphere. The pentagon transitions in the operator product expansion which systematize the series get reformulated in terms of matrix elements of branch-point twist operators in the two-dimensional O(6 nonlinear sigma model. The facts that the latter is an asymptotically free field theory and that there exists no local realization of twist fields prevents one from explicit calculation of their scaling dimensions and operator product expansion coefficients. This complication is bypassed making use of the equivalence of the sigma model to the infinite-level limit of WZNW models perturbed by current–current interactions, such that one can use conformal symmetry and conformal perturbation theory for systematic calculations. Presently, to set up the formalism, we consider the O(3 sigma model which is reformulated as perturbed parafermions.

  4. Electromagnetic couplings of the chiral perturbation theory Lagrangian from the perturbative chiral quark model

    Lyubovitskij, V.E.; Gutsche, Th.; Faessler, Amand; Mau, R. Vinh

    2002-01-01

    We apply the perturbative chiral quark model to the study of the low-energy πN interaction. Using an effective chiral Lagrangian we reproduce the Weinberg-Tomozawa result for the S-wave πN scattering lengths. After inclusion of the photon field we give predictions for the electromagnetic O(p 2 ) low-energy couplings of the chiral perturbation theory effective Lagrangian that define the electromagnetic mass shifts of nucleons and first-order (e 2 ) radiative corrections to the πN scattering amplitude. Finally, we estimate the leading isospin-breaking correction to the strong energy shift of the π - p atom in the 1s state, which is relevant for the experiment 'pionic hydrogen' at PSI

  5. Quantitative proteomics analysis reveals perturbation of lipid metabolic pathways in the liver of Atlantic cod (Gadus morhua) treated with PCB 153.

    Yadetie, Fekadu; Oveland, Eystein; Døskeland, Anne; Berven, Frode; Goksøyr, Anders; Karlsen, Odd André

    2017-04-01

    PCB 153 is one of the most abundant PCB congeners detected in biological samples. It is a persistent compound that is still present in the environment despite the ban on production and use of PCBs in the late 1970s. It has strong tendencies to bioaccumulate and biomagnify in biota, and studies have suggested that it is an endocrine and metabolic disruptor. In order to study mechanisms of toxicity, we exposed Atlantic cod (Gadus morhua) to various doses of PCB 153 (0, 0.5, 2 and 8mg/kg body weight) for two weeks and examined the effects on expression of liver proteins using label-free quantitative proteomics. Label-free liquid chromatography-mass spectrometry analysis of the liver proteome resulted in the quantification of 1272 proteins, of which 78 proteins were differentially regulated in the PCB 153-treated dose groups compared to the control group. Functional enrichment analysis showed that pathways significantly affected are related to lipid metabolism, cytoskeletal remodeling, cell cycle and cell adhesion. Importantly, the main effects appear to be on lipid metabolism, with up-regulation of enzymes in the de novo fatty acid synthesis pathway, consistent with previous transcriptomics results. Increased plasma triglyceride levels were also observed in the PCB 153 treated fish, in agreement with the induction of the lipogenic genes and proteins. The results suggest that PCB 153 perturbs lipid metabolism in the Atlantic cod liver. Elevated levels of lipogenic enzymes and plasma triglycerides further suggest increased synthesis of fatty acids and triglycerides. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Application of perturbation methods for sensitivity analysis for nuclear power plant steam generators; Aplicacao da teoria de perturbacao a analise de sensibilidade em geradores de vapor de usinas nucleares

    Gurjao, Emir Candeia

    1996-02-01

    The differential and GPT (Generalized Perturbation Theory) formalisms of the Perturbation Theory were applied in this work to a simplified U-tubes steam generator model to perform sensitivity analysis. The adjoint and importance equations, with the corresponding expressions for the sensitivity coefficients, were derived for this steam generator model. The system was numerically was numerically solved in a Fortran program, called GEVADJ, in order to calculate the sensitivity coefficients. A transient loss of forced primary coolant in the nuclear power plant Angra-1 was used as example case. The average and final values of functionals: secondary pressure and enthalpy were studied in relation to changes in the secondary feedwater flow, enthalpy and total volume in secondary circuit. Absolute variations in the above functionals were calculated using the perturbative methods, considering the variations in the feedwater flow and total secondary volume. Comparison with the same variations obtained via direct model showed in general good agreement, demonstrating the potentiality of perturbative methods for sensitivity analysis of nuclear systems. (author) 22 refs., 7 figs., 8 tabs.

  7. Analysis of positron annihilation lifetime data by numerical Laplace inversion: Corrections for source terms and zero-time shift errors

    Gregory, R.B.

    1991-01-01

    We have recently described modifications to the program CONTIN for the solution of Fredholm integral equations with convoluted kernels of the type that occur in the analysis of positron annihilation lifetime data. In this article, modifications to the program to correct for source terms in the sample and reference decay curves and for shifts in the position of the zero-time channel of the sample and reference data are described. Unwanted source components, expressed as a discrete sum of exponentials, may be removed from both the sample and reference data by modification of the sample data alone, without the need for direct knowledge of the instrument resolution function. Shifts in the position of the zero-time channel of up to half the channel width of the multichannel analyzer can be corrected. Analyses of computer-simulated test data indicate that the quality of the reconstructed annihilation rate probability density functions is improved by employing a refernce material with a short lifetime and indicate that reference materials which generate free positrons by quenching positronium formation (i.e. strong oxidizing agents) have lifetimes that are too long (400-450 ps) to provide reliable estimates of the lifetime parameters for the shortlived components with the methods described here. Well-annealed single crystals of metals with lifetimes less than 200 ps, such as molybdenum (123 ps) and aluminium (166 ps) do not introduce significant errors in estimates of the lifetime parameters and are to be preferred as reference materials. The performance of our modified version of CONTIN is illustrated by application to positron annihilation in polytetrafluoroethylene. (orig.)

  8. Retrospective characterization of ontogenetic shifts in killer whale diets via δ13C and δ15N analysis of teeth

    Newsome, Seth D.; Etnier, Michael A.; Monson, Daniel H.; Fogel, Marilyn L.

    2009-01-01

    Metabolically inert, accretionary structures such as the dentin growth layers in teeth provide a life history record of individual diet with near-annual resolution. We constructed ontogenetic δ13C and δ15N profiles by analyzing tooth dentin growth layers from 13 individual killer whales Orcinus orca collected in the eastern northeast Pacific Ocean between 1961 and 2003. The individuals sampled were 6 to 52 yr old, representing 2 ecotypes—resident and transient—collected across ~25° of latitude. The average isotopic values of transient individuals (n = 10) are consistent with a reliance on mammalian prey, while the average isotopic values of residents (n = 3) are consistent with piscivory. Regardless of ecotype, most individuals show a decrease in δ15N values of ~2.5‰ through the first 3 yr of life, roughly equivalent to a decrease of one trophic level. We interpret this as evidence of gradual weaning, after which, ontogenetic shifts in isotopic values are highly variable. A few individuals (n = 2) maintained relatively stable δ15N and δ13C values throughout the remainder of their lives, whereas δ15N values of most (n = 11) increased by ~1.5‰, suggestive of an ontogenetic increase in trophic level. Significant differences in mean δ13C and δ15N values among transients collected off California suggest that individuality in prey preferences may be prevalent within this ecotype. Our approach provides retrospective individual life history and dietary information that cannot be obtained through traditional field observations of free-ranging and elusive species such as killer whales, including unique historic ecological information that pre-dates modern studies. By providing insights into individual diet composition, stable isotope analysis of teeth and/or bones may be the only means of evaluating a number of hypothesized historical dietary shifts in killer whales of the northeast Pacific Ocean

  9. Night Shift Work and Breast Cancer Incidence: Three Prospective Studies and Meta-analysis of Published Studies

    Travis, Ruth C.; Balkwill, Angela; Fensom, Georgina K.; Appleby, Paul N.; Reeves, Gillian K.; Wang, Xiao-Si; Roddam, Andrew W.; Gathani, Toral; Peto, Richard; Green, Jane; Key, Timothy J.; Beral, Valerie

    2016-01-01

    Background: It has been proposed that night shift work could increase breast cancer incidence. A 2007 World Health Organization review concluded, mainly from animal evidence, that shift work involving circadian disruption is probably carcinogenic to humans. We therefore aimed to generate prospective epidemiological evidence on night shift work and breast cancer incidence. Methods: Overall, 522 246 Million Women Study, 22 559 EPIC-Oxford, and 251 045 UK Biobank participants answered questions ...

  10. Improved proton-deuteron phase-shift analysis above the deuteron breakup threshold and the three-nucleon analyzing-power puzzle

    Tornow, W; Witala, H

    2002-01-01

    Using the existing high-accuracy data for proton-deuteron and deuteron-proton elastic scattering, a phase-shift analysis has been performed in the laboratory proton energy range from E sub p = 4 to 10 MeV The AV 18-based proton-deuteron phase shifts were used as starting values in the phase-shift search procedure. The low-partial wave phase shifts, especially the sup 4 P sub j phase shifts have been determined very precisely, thus providing valuable guidance for theoretical approaches to tackle the quest for a successful description of three-nucleon bound-state and continuum observables in a more efficient and consistent way. Furthermore, it was found that the sup 4 P sub 1 sub / sub 2 phase shift and the mixing parameter epsilon sub 3 sub / sub 2 sub sup - determined in the present analysis cannot be generated by sup 3 P sub j nucleon-nucleon interactions which are consistent with two-nucleon analyzing power data. Therefore, three-nucleon forces must play an essential role in resolving the long-standing thre...

  11. Improved proton-deuteron phase-shift analysis above the deuteron breakup threshold and the three-nucleon analyzing-power puzzle

    Tornow, W.; Kievsky, A.; Witala, H.

    2002-01-01

    Using the existing high-accuracy data for proton-deuteron and deuteron-proton elastic scattering, a phase-shift analysis has been performed in the laboratory proton energy range from E p = 4 to 10 MeV The AV 18-based proton-deuteron phase shifts were used as starting values in the phase-shift search procedure. The low-partial wave phase shifts, especially the 4 P j phase shifts have been determined very precisely, thus providing valuable guidance for theoretical approaches to tackle the quest for a successful description of three-nucleon bound-state and continuum observables in a more efficient and consistent way. Furthermore, it was found that the 4 P 1/2 phase shift and the mixing parameter ε 3/2 - determined in the present analysis cannot be generated by 3 P j nucleon-nucleon interactions which are consistent with two-nucleon analyzing power data. Therefore, three-nucleon forces must play an essential role in resolving the long-standing three-nucleon analyzing-power puzzle. Refs. 44 (author)

  12. Fluid Shifts

    Stenger, M. B.; Hargens, A. R.; Dulchavsky, S. A.; Arbeille, P.; Danielson, R. W.; Ebert, D. J.; Garcia, K. M.; Johnston, S. L.; Laurie, S. S.; Lee, S. M. C.; hide

    2017-01-01

    Introduction. NASA's Human Research Program is focused on addressing health risks associated with long-duration missions on the International Space Station (ISS) and future exploration-class missions beyond low Earth orbit. Visual acuity changes observed after short-duration missions were largely transient, but now more than 50 percent of ISS astronauts have experienced more profound, chronic changes with objective structural findings such as optic disc edema, globe flattening and choroidal folds. These structural and functional changes are referred to as the visual impairment and intracranial pressure (VIIP) syndrome. Development of VIIP symptoms may be related to elevated intracranial pressure (ICP) secondary to spaceflight-induced cephalad fluid shifts, but this hypothesis has not been tested. The purpose of this study is to characterize fluid distribution and compartmentalization associated with long-duration spaceflight and to determine if a relation exists with vision changes and other elements of the VIIP syndrome. We also seek to determine whether the magnitude of fluid shifts during spaceflight, as well as any VIIP-related effects of those shifts, are predicted by the crewmember's pre-flight status and responses to acute hemodynamic manipulations, specifically posture changes and lower body negative pressure. Methods. We will examine a variety of physiologic variables in 10 long-duration ISS crewmembers using the test conditions and timeline presented in the figure below. Measures include: (1) fluid compartmentalization (total body water by D2O, extracellular fluid by NaBr, intracellular fluid by calculation, plasma volume by CO rebreathe, interstitial fluid by calculation); (2) forehead/eyelids, tibia, and calcaneus tissue thickness (by ultrasound); (3) vascular dimensions by ultrasound (jugular veins, cerebral and carotid arteries, vertebral arteries and veins, portal vein); (4) vascular dynamics by MRI (head/neck blood flow, cerebrospinal fluid

  13. Analysis of self-consistency effects in range-separated density-functional theory with Møller-Plesset perturbation theory

    Fromager, Emmanuel; Jensen, Hans Jørgen Aagaard

    2011-01-01

    Range-separated density-functional theory combines wave function theory for the long-range part of the two-electron interaction with density-functional theory for the short-range part. When describing the long-range interaction with non-variational methods, such as perturbation or coupled......-cluster theories, self-consistency effects are introduced in the density functional part, which for an exact solution requires iterations. They are generally assumed to be small but no detailed study has been performed so far. Here, the authors analyze self-consistency when using Møller-Plesset-type (MP......) perturbation theory for the long range interaction. The lowest-order self-consistency corrections to the wave function and the energy, that enter the perturbation expansions at the second and fourth order, respectively, are both expressed in terms of the one-electron reduced density matrix. The computational...

  14. GC/TOFMS analysis of metabolites in serum and urine reveals metabolic perturbation of TCA cycle in db/db mice involved in diabetic nephropathy.

    Li, Mengjie; Wang, Xufang; Aa, Jiye; Qin, Weisong; Zha, Weibin; Ge, Yongchun; Liu, Linsheng; Zheng, Tian; Cao, Bei; Shi, Jian; Zhao, Chunyan; Wang, Xinwen; Yu, Xiaoyi; Wang, Guangji; Liu, Zhihong

    2013-06-01

    Early diagnosis of diabetic nephropathy (DN) is difficult although it is of crucial importance to prevent its development. To probe potential markers and the underlying mechanism of DN, an animal model of DN, the db/db mice, was used and serum and urine metabolites were profiled using gas chromatography/time-of-flight mass spectrometry. Metabolic patterns were evaluated based on serum and urine data. Principal component analysis of the data revealed an obvious metabonomic difference between db/db mice and controls, and db/db mice showed distinctly different metabolic patterns during the progression from diabetes to early, medium, and later DN. The identified metabolites discriminating between db/db mice and controls suggested that db/db mice have perturbations in the tricarboxylic acid cycle (TCA, citrate, malate, succinate, and aconitate), lipid metabolism, glycolysis, and amino acid turnover. The db/db mice were characterized by acidic urine, high TCA intermediates in serum at week 6 and a sharp decline thereafter, and gradual elevation of free fatty acids in the serum. The sharp drop of serum TCA intermediates from week 6 to 8 indicated the downregulated glycolysis and insulin resistance. However, urinary TCA intermediates did not decrease in parallel with those in the serum from week 6 to 10, and an increased portion of TCA intermediates in the serum was excreted into the urine at 8, 10, and 12 wk than at 6 wk, indicating kidney dysfunction occurred. The relative abundances of TCA intermediates in urine relative to those in serum were suggested as an index of renal damage.

  15. Differential Expression Analysis by RNA-Seq Reveals Perturbations in the Platelet mRNA Transcriptome Triggered by Pathogen Reduction Systems.

    Abdimajid Osman

    Full Text Available Platelet concentrates (PCs are prepared at blood banks for transfusion to patients in certain clinical conditions associated with a low platelet count. To prevent transfusion-transmitted infections via PCs, different pathogen reduction (PR systems have been developed that inactivate the nucleic acids of contaminating pathogens by chemical cross-linking, a mechanism that may also affect platelets' nucleic acids. We previously reported that treatment of stored platelets with the PR system Intercept significantly reduced the level of half of the microRNAs that were monitored, induced platelet activation and compromised the platelet response to physiological agonists. Using genome-wide differential expression (DE RNA sequencing (RNA-Seq, we now report that Intercept markedly perturbs the mRNA transcriptome of human platelets and alters the expression level of >800 mRNAs (P<0.05 compared to other PR systems and control platelets. Of these, 400 genes were deregulated with DE corresponding to fold changes (FC ≥ 2. At the p-value < 0.001, as many as 147 genes were deregulated by ≥ 2-fold in Intercept-treated platelets, compared to none in the other groups. Finally, integrated analysis combining expression data for microRNA (miRNA and mRNA, and involving prediction of miRNA-mRNA interactions, disclosed several positive and inverse correlations between miRNAs and mRNAs in stored platelets. In conclusion, this study demonstrates that Intercept markedly deregulates the platelet mRNA transcriptome, concomitant with reduced levels of mRNA-regulatory miRNAs. These findings should enlighten authorities worldwide when considering the implementation of PR systems, that target nucleic acids and are not specific to pathogens, for the management of blood products.

  16. Non-Abelian integrable hierarchies: matrix biorthogonal polynomials and perturbations

    Ariznabarreta, Gerardo; García-Ardila, Juan C.; Mañas, Manuel; Marcellán, Francisco

    2018-05-01

    In this paper, Geronimus–Uvarov perturbations for matrix orthogonal polynomials on the real line are studied and then applied to the analysis of non-Abelian integrable hierarchies. The orthogonality is understood in full generality, i.e. in terms of a nondegenerate continuous sesquilinear form, determined by a quasidefinite matrix of bivariate generalized functions with a well-defined support. We derive Christoffel-type formulas that give the perturbed matrix biorthogonal polynomials and their norms in terms of the original ones. The keystone for this finding is the Gauss–Borel factorization of the Gram matrix. Geronimus–Uvarov transformations are considered in the context of the 2D non-Abelian Toda lattice and noncommutative KP hierarchies. The interplay between transformations and integrable flows is discussed. Miwa shifts, τ-ratio matrix functions and Sato formulas are given. Bilinear identities, involving Geronimus–Uvarov transformations, first for the Baker functions, then secondly for the biorthogonal polynomials and its second kind functions, and finally for the τ-ratio matrix functions, are found.

  17. Non-Perturbative Renormalization

    Mastropietro, Vieri

    2008-01-01

    The notion of renormalization is at the core of several spectacular achievements of contemporary physics, and in the last years powerful techniques have been developed allowing to put renormalization on a firm mathematical basis. This book provides a self-consistent and accessible introduction to the sophisticated tools used in the modern theory of non-perturbative renormalization, allowing an unified and rigorous treatment of Quantum Field Theory, Statistical Physics and Condensed Matter models. In particular the first part of this book is devoted to Constructive Quantum Field Theory, providi

  18. Perturbative quantum chromodynamics

    1989-01-01

    This book will be of great interest to advanced students and researchers in the area of high energy theoretical physics. Being the most complete and updated review volume on Perturbative QCD, it serves as an extremely useful textbook or reference book. Some of the reviews in this volume are the best that have been written on the subject anywhere. Contents: Factorization of Hard Processes in QCD (J C Collins, D E Soper & G Sterman); Exclusive Processes in Quantum Chromodynamics (S J Brodsky & G P Lepage); Coherence and Physics of QCD Jets (Yu L Dokshitzer, V A Khoze & S I Troyan); Pomeron in Qu

  19. Perturbative quantum chromodynamics

    Radyushkin, A.V.

    1987-01-01

    The latest achievements in perturbative quantum chromodynamics (QCD) relating to the progress in factorization of small and large distances are presented. The following problems are concerned: Development of the theory of Sudakov effects on the basis of mean contour formalism. Development of nonlocal condensate formalism. Calculation of hadron wave functions and hadron distribution functions using QCD method of sum rules. Development of the theory of Regge behaviour in QCD, behaviour of structure functions at small x. Study of polarization effects in hadron processes with high momentum transfer

  20. Perturbed effects at radiation physics

    Külahcı, Fatih; Şen, Zekâi

    2013-01-01

    Perturbation methodology is applied in order to assess the linear attenuation coefficient, mass attenuation coefficient and cross-section behavior with random components in the basic variables such as the radiation amounts frequently used in the radiation physics and chemistry. Additionally, layer attenuation coefficient (LAC) and perturbed LAC (PLAC) are proposed for different contact materials. Perturbation methodology provides opportunity to obtain results with random deviations from the average behavior of each variable that enters the whole mathematical expression. The basic photon intensity variation expression as the inverse exponential power law (as Beer–Lambert's law) is adopted for perturbation method exposition. Perturbed results are presented not only in terms of the mean but additionally the standard deviation and the correlation coefficients. Such perturbation expressions provide one to assess small random variability in basic variables. - Highlights: • Perturbation methodology is applied to Radiation Physics. • Layer attenuation coefficient (LAC) and perturbed LAC are proposed for contact materials. • Perturbed linear attenuation coefficient is proposed. • Perturbed mass attenuation coefficient (PMAC) is proposed. • Perturbed cross-section is proposed

  1. Simplification and Shift in Cognition of Political Difference: Applying the Geometric Modeling to the Analysis of Semantic Similarity Judgment

    Kato, Junko; Okada, Kensuke

    2011-01-01

    Perceiving differences by means of spatial analogies is intrinsic to human cognition. Multi-dimensional scaling (MDS) analysis based on Minkowski geometry has been used primarily on data on sensory similarity judgments, leaving judgments on abstractive differences unanalyzed. Indeed, analysts have failed to find appropriate experimental or real-life data in this regard. Our MDS analysis used survey data on political scientists' judgments of the similarities and differences between political positions expressed in terms of distance. Both distance smoothing and majorization techniques were applied to a three-way dataset of similarity judgments provided by at least seven experts on at least five parties' positions on at least seven policies (i.e., originally yielding 245 dimensions) to substantially reduce the risk of local minima. The analysis found two dimensions, which were sufficient for mapping differences, and fit the city-block dimensions better than the Euclidean metric in all datasets obtained from 13 countries. Most city-block dimensions were highly correlated with the simplified criterion (i.e., the left–right ideology) for differences that are actually used in real politics. The isometry of the city-block and dominance metrics in two-dimensional space carries further implications. More specifically, individuals may pay attention to two dimensions (if represented in the city-block metric) or focus on a single dimension (if represented in the dominance metric) when judging differences between the same objects. Switching between metrics may be expected to occur during cognitive processing as frequently as the apparent discontinuities and shifts in human attention that may underlie changing judgments in real situations occur. Consequently, the result has extended strong support for the validity of the geometric models to represent an important social cognition, i.e., the one of political differences, which is deeply rooted in human nature. PMID:21673959

  2. Predicting phase shift of elastic waves in pipes due to fluid flow and imperfections

    Thomsen, Jon Juel; Dahl, Jonas; Fuglede, Niels

    2009-01-01

    . This is relevant for understanding wave propagation in elastic media in general, and for the design and trouble-shooting of phase-shift measuring devices such as Coriolis mass flowmeters in particular. A multiple time scaling perturbation analysis is employed for a simple model of a fluid-conveying pipe......Flexural vibrations of a fluid-conveying pipe is investigated, with special consideration to the spatial shift in phase caused by fluid flow and various imperfections, e.g., non-ideal supports, non-uniform stiffness or mass, non-proportional damping, weak nonlinearity, and flow pulsation...

  3. DEPTH-CHARGE static and time-dependent perturbation/sensitivity system for nuclear reactor core analysis. Revision I. [DEPTH-CHARGE code

    White, J.R.

    1985-04-01

    This report provides the background theory, user input, and sample problems required for the efficient application of the DEPTH-CHARGE system - a code black for both static and time-dependent perturbation theory and data sensitivity analyses. The DEPTH-CHARGE system is of modular construction and has been implemented within the VENTURE-BURNER computational system at Oak Ridge National Laboratory. The DEPTH module (coupled with VENTURE) solves for the three adjoint functions of Depletion Perturbation Theory and calculates the desired time-dependent derivatives of the response with respect to the nuclide concentrations and nuclear data utilized in the reference model. The CHARGE code is a collection of utility routines for general data manipulation and input preparation and considerably extends the usefulness of the system through the automatic generation of adjoint sources, estimated perturbed responses, and relative data sensitivity coefficients. Combined, the DEPTH-CHARGE system provides, for the first time, a complete generalized first-order perturbation/sensitivity theory capability for both static and time-dependent analyses of realistic multidimensional reactor models. This current documentation incorporates minor revisions to the original DEPTH-CHARGE documentation (ORNL/CSD-78) to reflect some new capabilities within the individual codes.

  4. Symbolic derivation of high-order Rayleigh-Schroedinger perturbation energies using computer algebra: Application to vibrational-rotational analysis of diatomic molecules

    Herbert, John M. [Kansas State Univ., Manhattan, KS (United States). Dept. of Chemistry

    1997-01-01

    Rayleigh-Schroedinger perturbation theory is an effective and popular tool for describing low-lying vibrational and rotational states of molecules. This method, in conjunction with ab initio techniques for computation of electronic potential energy surfaces, can be used to calculate first-principles molecular vibrational-rotational energies to successive orders of approximation. Because of mathematical complexities, however, such perturbation calculations are rarely extended beyond the second order of approximation, although recent work by Herbert has provided a formula for the nth-order energy correction. This report extends that work and furnishes the remaining theoretical details (including a general formula for the Rayleigh-Schroedinger expansion coefficients) necessary for calculation of energy corrections to arbitrary order. The commercial computer algebra software Mathematica is employed to perform the prohibitively tedious symbolic manipulations necessary for derivation of generalized energy formulae in terms of universal constants, molecular constants, and quantum numbers. As a pedagogical example, a Hamiltonian operator tailored specifically to diatomic molecules is derived, and the perturbation formulae obtained from this Hamiltonian are evaluated for a number of such molecules. This work provides a foundation for future analyses of polyatomic molecules, since it demonstrates that arbitrary-order perturbation theory can successfully be applied with the aid of commercially available computer algebra software.

  5. Ultra-short FBG based distributed sensing using shifted optical Gaussian filters and microwave-network analysis.

    Cheng, Rui; Xia, Li; Sima, Chaotan; Ran, Yanli; Rohollahnejad, Jalal; Zhou, Jiaao; Wen, Yongqiang; Yu, Can

    2016-02-08

    Ultrashort fiber Bragg gratings (US-FBGs) have significant potential as weak grating sensors for distributed sensing, but the exploitation have been limited by their inherent broad spectra that are undesirable for most traditional wavelength measurements. To address this, we have recently introduced a new interrogation concept using shifted optical Gaussian filters (SOGF) which is well suitable for US-FBG measurements. Here, we apply it to demonstrate, for the first time, an US-FBG-based self-referencing distributed optical sensing technique, with the advantages of adjustable sensitivity and range, high-speed and wide-range (potentially >14000 με) intensity-based detection, and resistance to disturbance by nonuniform parameter distribution. The entire system is essentially based on a microwave network, which incorporates the SOGF with a fiber delay-line between the two arms. Differential detections of the cascaded US-FBGs are performed individually in the network time-domain response which can be obtained by analyzing its complex frequency response. Experimental results are presented and discussed using eight cascaded US-FBGs. A comprehensive numerical analysis is also conducted to assess the system performance, which shows that the use of US-FBGs instead of conventional weak FBGs could significantly improve the power budget and capacity of the distributed sensing system while maintaining the crosstalk level and intensity decay rate, providing a promising route for future sensing applications.

  6. Physico-chemical properties of perturbed water: facts and enigmas

    Vittorio Elia

    2012-01-01

    Background The study of extremely diluted and agitated substances and solutions is strictly linked with the analysis of properties of water perturbed using different systems. This study is about the determination of the physical-chemical parameters of water, after the perturbations described. Methods The perturbed water was obtained using the three different protocols: · EDS (Extremely Diluted Solutions). Obtained through an iterative process of ...

  7. Non-perturbative versus perturbative renormalization of lattice operators

    Goeckeler, M.; Technische Hochschule Aachen; Horsley, R.; Ilgenfritz, E.M.; Oelrich, H.; Forschungszentrum Juelich GmbH; Schierholz, G.; Forschungszentrum Juelich GmbH; Perlt, H.; Schiller, A.; Rakow, P.

    1995-09-01

    Our objective is to compute the moments of the deep-inelastic structure functions of the nucleon on the lattice. A major source of uncertainty is the renormalization of the lattice operators that enter the calculation. In this talk we compare the renormalization constants of the most relevant twist-two bilinear quark operators which we have computed non-perturbatively and perturbatively to one loop order. Furthermore, we discuss the use of tadpole improved perturbation theory. (orig.)

  8. Operator Decomposition Framework for Perturbation Theory

    Abdel-Khalik, Hany S.; Wang, Congjian; Bang, Young Suk [North Carolina State University, Raleigh (United States)

    2012-05-15

    This summary describes a new framework for perturbation theory intended to improve its performance, in terms of the associated computational cost and the complexity of implementation, for routine reactor calculations in support of design, analysis, and regulation. Since its first introduction in reactor analysis by Winger, perturbation theory has assumed an aura of sophistication with regard to its implementation and its capabilities. Only few reactor physicists, typically mathematically proficient, have contributed to its development, with the general body of the nuclear engineering community remaining unaware of its current status, capabilities, and challenges. Given its perceived sophistication and the small body of community users, the application of perturbation theory has been limited to investigatory analyses only. It is safe to say that the nuclear community is split into two groups, a small one which understands the theory and, and a much bigger group with the perceived notion that perturbation theory is nothing but a fancy mathematical approach that has very little use in practice. Over the past three years, research has demonstrated two goals. First, reduce the computational cost of perturbation theory in order to enable its use for routine reactor calculations. Second, expose some of the myth about perturbation theory and present it in a form that is simple and relatable in order to stimulate the interest of nuclear practitioners, especially those who are currently working on the development of next generation reactor design and analysis tools. The operator decomposition approach has its roots in linear algebra and can be easily understood by code developers, especially those involved in the design of iterative numerical solution strategies

  9. Does the association of prostate cancer with night-shift work differ according to rotating vs. fixed schedule? A systematic review and meta-analysis.

    Mancio, Jennifer; Leal, Cátia; Ferreira, Marta; Norton, Pedro; Lunet, Nuno

    2018-04-27

    Recent studies suggested that the relation between night-shift work and prostate cancer may differ between rotating and fixed schedules. We aimed to quantify the independent association between night-shift work and prostate cancer, for rotating and fixed schedules. We searched MEDLINE for studies assessing the association of night-shift work, by rotating or fixed schedules, with prostate cancer. We computed summary relative risk (RR) estimates with 95% confidence intervals (95% CI) using the inverse variance method and quantified heterogeneity using the I 2 statistic. Meta-regression analysis was used to compare the summary RR estimates for rotating and fixed schedules, while reducing heterogeneity. A total of nine studies assessed the effect of rotating and, in addition, four of them provided the effect of fixed night-shift work, in relation to daytime workers. Rotating night-shift work was associated with a significantly increased risk of prostate cancer (RR = 1.06, 95% CI of 1.01 to 1.12; I 2  = 50%), but not fixed night-shift work (RR of 1.01, 95% CI of 0.81 to 1.26; I 2  = 33%). In meta-regression model including study design, type of population, and control of confounding, the summary RR was 20% higher for rotating vs. fixed schedule, with heterogeneity fully explained by these variables. This is the first meta-analysis suggesting that an increased risk of prostate cancer may be restricted to workers with rotating night shifts. However, the association was weak and additional studies are needed to further clarify this relation before it can be translated into measures for risk reduction in occupational settings.

  10. A Bottom-up Vulnerability Analysis of Water Systems with Decentralized Decision Making and Demographic Shifts- the Case of Jordan.

    Lachaut, T.; Yoon, J.; Klassert, C. J. A.; Talozi, S.; Mustafa, D.; Knox, S.; Selby, P. D.; Haddad, Y.; Gorelick, S.; Tilmant, A.

    2016-12-01

    Probabilistic approaches to uncertainty in water systems management can face challenges of several types: non stationary climate, sudden shocks such as conflict-driven migrations, or the internal complexity and dynamics of large systems. There has been a rising trend in the development of bottom-up methods that place focus on the decision side instead of probability distributions and climate scenarios. These approaches are based on defining acceptability thresholds for the decision makers and considering the entire range of possibilities over which such thresholds are crossed. We aim at improving the knowledge on the applicability and relevance of this approach by enlarging its scope beyond climate uncertainty and single decision makers; thus including demographic shifts, internal system dynamics, and multiple stakeholders at different scales. This vulnerability analysis is part of the Jordan Water Project and makes use of an ambitious multi-agent model developed by its teams with the extensive cooperation of the Ministry of Water and Irrigation of Jordan. The case of Jordan is a relevant example for migration spikes, rapid social changes, resource depletion and climate change impacts. The multi-agent modeling framework used provides a consistent structure to assess the vulnerability of complex water resources systems with distributed acceptability thresholds and stakeholder interaction. A proof of concept and preliminary results are presented for a non-probabilistic vulnerability analysis that involves different types of stakeholders, uncertainties other than climatic and the integration of threshold-based indicators. For each stakeholder (agent) a vulnerability matrix is constructed over a multi-dimensional domain, which includes various hydrologic and/or demographic variables.

  11. Molecular-level mechanisms of vibrational frequency shifts in a polar liquid.

    Morales, Christine M; Thompson, Ward H

    2011-06-16

    A molecular-level analysis of the origins of the vibrational frequency shifts of the CN stretching mode in neat liquid acetonitrile is presented. The frequency shifts and infrared spectrum are calculated using a perturbation theory approach within a molecular dynamics simulation and are in good agreement with measured values reported in the literature. The resulting instantaneous frequency of each nitrile group is decomposed into the contributions from each molecule in the liquid and by interaction type. This provides a detailed picture of the mechanisms of frequency shifts, including the number of surrounding molecules that contribute to the shift, the relationship between their position and relative contribution, and the roles of electrostatic and van der Waals interactions. These results provide insight into what information is contained in infrared (IR) and Raman spectra about the environment of the probed vibrational mode. © 2011 American Chemical Society

  12. Perturbation studies on KAHTER

    Rueckert, M.; Jonas, H.; Neef, R. D.

    1974-10-15

    The paper describes experimental and analytical results by both transport theory and diffusion theory calculations of perturbation tests in the KAHTER pebble bed critical experiment. The fission-weighted adjoint flux is measured from in-core detector responses by introducing a Cf-source into the core. Adjoint-weighted reactivities are calculated and compared to reactivity measurements for the introduction of a fuel and graphite pebble onto the top of the critical pile, the central rod worth, and the effect of replacing B4C with varying amounts of HfC in the central rod. In addition, analytical studies were made of the sensitivity of criticality to the fuel to graphite pebble ratio as measured in tests and of the effect of the upper void cavity as simulated in tests by placing cadmium layer across the top of the pebble pile to force a zero flux boundary condition.

  13. Introduction to perturbation methods

    Holmes, M

    1995-01-01

    This book is an introductory graduate text dealing with many of the perturbation methods currently used by applied mathematicians, scientists, and engineers. The author has based his book on a graduate course he has taught several times over the last ten years to students in applied mathematics, engineering sciences, and physics. The only prerequisite for the course is a background in differential equations. Each chapter begins with an introductory development involving ordinary differential equations. The book covers traditional topics, such as boundary layers and multiple scales. However, it also contains material arising from current research interest. This includes homogenization, slender body theory, symbolic computing, and discrete equations. One of the more important features of this book is contained in the exercises. Many are derived from problems of up- to-date research and are from a wide range of application areas.

  14. Perturbation theory with instantons

    Carruthers, P.; Pinsky, S.S.; Zachariasen, F.

    1977-05-01

    ''Perturbation theory'' rules are developed for calculating the effect of instantons in a pure Yang-Mills theory with no fermions, in the ''dilute gas'' approximation in which the N-instanton solution is assumed to be the sum of N widely separated one-instanton solutions. These rules are then used to compute the gluon propagator and proper vertex function including all orders of the instanton interaction but only to lowest order in the gluon coupling. It is to be expected that such an approximation is valid only for momenta q larger than the physical mass μ. The result is that in this regime instantons cause variations in the propagator and vertex of the form (μ 2 /q 2 )/sup -8π 2 b/ where b is the coefficient in the expansion of the β function: β = bg 3 +...

  15. Use of lanthanide shift reagents together with silver trifluoroacetate for quantitative analysis of mixtures of aromatic hydrocarbons

    Dambska, A.; Janowski, A.

    1980-01-01

    The shifts induced by equimolar mixture of typical lanthanide shift reagent such as 2,2-dimethyl-6,6,7,7,8,8,8-heptafluoro-3,5-octadionato europium with silver trifluoroacetate in 1 H NMR spectra of aromatic hydrocarbons have been used for analytical purposes; the NMR determination of m- and p-xylenes in mixtures has been chosen as an example. The use has been made of difference between induced shifts of methyl group signals in the 1 H NMR spectra of m- and p-xylenes. The magnitude of induced shifts of methyl groups signal in m-xylene is always larger than that of p-isomer, irrespective of contents of m- and p-xylenes in mixture. (author)

  16. Generating ekpyrotic curvature perturbations before the big bang

    Lehners, Jean-Luc; Turok, Neil; McFadden, Paul; Steinhardt, Paul J.

    2007-01-01

    We analyze a general mechanism for producing a nearly scale-invariant spectrum of cosmological curvature perturbations during a contracting phase preceding a big bang, which can be entirely described using 4D effective field theory. The mechanism, based on first producing entropic perturbations and then converting them to curvature perturbations, can be naturally incorporated in cyclic and ekpyrotic models in which the big bang is modeled as a brane collision, as well as other types of cosmological models with a pre-big bang phase. We show that the correct perturbation amplitude can be obtained and that the spectral tilt n s tends to range from slightly blue to red, with 0.97 s <1.02 for the simplest models, a range compatible with current observations but shifted by a few percent towards the blue compared to the prediction of the simplest, large-field inflationary models

  17. Redshift-space distortions from vector perturbations

    Bonvin, Camille; Durrer, Ruth; Khosravi, Nima; Kunz, Martin; Sawicki, Ignacy

    2018-02-01

    We compute a general expression for the contribution of vector perturbations to the redshift space distortion of galaxy surveys. We show that they contribute to the same multipoles of the correlation function as scalar perturbations and should thus in principle be taken into account in data analysis. We derive constraints for next-generation surveys on the amplitude of two sources of vector perturbations, namely non-linear clustering and topological defects. While topological defects leave a very small imprint on redshift space distortions, we show that the multipoles of the correlation function are sensitive to vorticity induced by non-linear clustering. Therefore future redshift surveys such as DESI or the SKA should be capable of measuring such vector modes, especially with the hexadecapole which appears to be the most sensitive to the presence of vorticity.

  18. Shifting Norms and Expectations for Medical School Leaders: A Textual Analysis of Career Advertisements 2000-2004 cf. 2010-2014

    Gorsky, Diane; MacLeod, Anna

    2016-01-01

    Leadership norms and expectations are continually evolving in higher education. Medical education is no exception to that trend, but shifts over time are intangible and difficult to measure. To explore emerging changes, the authors conducted a textual analysis of published career advertisements from 2000-2004 and 2010-2014. While a number of…

  19. Shifting Sugars and Shifting Paradigms

    Siegal, Mark L.

    2015-01-01

    No organism lives in a constant environment. Based on classical studies in molecular biology, many have viewed microbes as following strict rules for shifting their metabolic activities when prevailing conditions change. For example, students learn that the bacterium Escherichia coli makes proteins for digesting lactose only when lactose is available and glucose, a better sugar, is not. However, recent studies, including three PLOS Biology papers examining sugar utilization in the budding yeast Saccharomyces cerevisiae, show that considerable heterogeneity in response to complex environments exists within and between populations. These results join similar recent results in other organisms that suggest that microbial populations anticipate predictable environmental changes and hedge their bets against unpredictable ones. The classical view therefore represents but one special case in a range of evolutionary adaptations to environmental changes that all organisms face. PMID:25688600

  20. Shifting sugars and shifting paradigms.

    Mark L Siegal

    2015-02-01

    Full Text Available No organism lives in a constant environment. Based on classical studies in molecular biology, many have viewed microbes as following strict rules for shifting their metabolic activities when prevailing conditions change. For example, students learn that the bacterium Escherichia coli makes proteins for digesting lactose only when lactose is available and glucose, a better sugar, is not. However, recent studies, including three PLOS Biology papers examining sugar utilization in the budding yeast Saccharomyces cerevisiae, show that considerable heterogeneity in response to complex environments exists within and between populations. These results join similar recent results in other organisms that suggest that microbial populations anticipate predictable environmental changes and hedge their bets against unpredictable ones. The classical view therefore represents but one special case in a range of evolutionary adaptations to environmental changes that all organisms face.

  1. Nonlinear spherical perturbations in quintessence models of dark energy

    Pratap Rajvanshi, Manvendra; Bagla, J. S.

    2018-06-01

    Observations have confirmed the accelerated expansion of the universe. The accelerated expansion can be modelled by invoking a cosmological constant or a dynamical model of dark energy. A key difference between these models is that the equation of state parameter w for dark energy differs from ‑1 in dynamical dark energy (DDE) models. Further, the equation of state parameter is not constant for a general DDE model. Such differences can be probed using the variation of scale factor with time by measuring distances. Another significant difference between the cosmological constant and DDE models is that the latter must cluster. Linear perturbation analysis indicates that perturbations in quintessence models of dark energy do not grow to have a significant amplitude at small length scales. In this paper we study the response of quintessence dark energy to non-linear perturbations in dark matter. We use a fully relativistic model for spherically symmetric perturbations. In this study we focus on thawing models. We find that in response to non-linear perturbations in dark matter, dark energy perturbations grow at a faster rate than expected in linear perturbation theory. We find that dark energy perturbation remains localised and does not diffuse out to larger scales. The dominant drivers of the evolution of dark energy perturbations are the local Hubble flow and a supression of gradients of the scalar field. We also find that the equation of state parameter w changes in response to perturbations in dark matter such that it also becomes a function of position. The variation of w in space is correlated with density contrast for matter. Variation of w and perturbations in dark energy are more pronounced in response to large scale perturbations in matter while the dependence on the amplitude of matter perturbations is much weaker.

  2. Lanthanide shift reagents, binding, shift mechanisms and exchange

    Boer, J.W.M. de

    1977-01-01

    Paramagnetic lanthanide shift reagents, when added to a solution of a substrate, induce shifts in the nuclear magnetic resonance (NMR) spectrum of the substrate molecules. The induced shifts contain information about the structure of the shift reagent substrate complex. The structural information, however, may be difficult to extract because of the following effects: (1) different complexes between shift reagent and substrate may be present in solution, e.g. 1:1 and 1:2 complexes, and the shift observed is a weighed average of the shifts of the substrate nuclei in the different complexes; (2) the Fermi contact interaction, arising from the spin density at the nucleus, contributes to the induced shift; (3) chemical exchange effects may complicate the NMR spectrum. In this thesis, the results of an investigation into the influence of these effects on the NMR spectra of solutions containing a substrate and LSR are presented. The equations describing the pseudo contact and the Fermi contact shift are derived. In addition, it is shown how the modified Bloch equations describing the effect of the chemical exchange processes occurring in the systems studied can be reduced to the familiar equations for a two-site exchange case. The binding of mono- and bifunctional ethers to the shift reagent are reported. An analysis of the induced shifts is given. Finally, the results of the experiments performed to study the exchange behavior of dimethoxyethane and heptafluorodimethyloctanedionato ligands are presented

  3. Noise Reduction in High-Throughput Gene Perturbation Screens

    Motivation: Accurate interpretation of perturbation screens is essential for a successful functional investigation. However, the screened phenotypes are often distorted by noise, and their analysis requires specialized statistical analysis tools. The number and scope of statistical methods available...

  4. Resummation of divergent perturbation series: Application to the vibrational states of H{sub 2}CO molecule

    Duchko, A. N. [National Research Tomsk Polytechnic University, Tomsk (Russian Federation); V.E. Zuev Institute of Atmospheric Optics, Tomsk (Russian Federation); Bykov, A. D., E-mail: adbykov@rambler.ru [V.E. Zuev Institute of Atmospheric Optics, Tomsk (Russian Federation)

    2015-10-21

    Large-order Rayleigh–Schrödinger perturbation theory (RSPT) is applied to the calculation of anharmonic vibrational energy levels of H{sub 2}CO molecule. We use the model of harmonic oscillators perturbed by anharmonic terms of potential energy. Since the perturbation series typically diverge due to strong couplings, we apply the algebraic approximation technique because of its effectiveness shown earlier by Goodson and Sergeev [J. Chem. Phys. 110, 8205 (1999); ibid. 124, 094111 (2006)] and in our previous articles [A. D. Bykov et al. Opt. Spectrosc. 114, 396 (2013); ibid. 116, 598 (2014)]. To facilitate the resummation of terms contributing to perturbed states, when resonance mixing between states is especially strong and perturbation series diverge very quick, we used repartition of the Hamiltonian by shifting the normal mode frequencies. Energy levels obtained by algebraic approximants were compared with the results of variational calculation. It was found that for low energy states (up to ∼5000 cm{sup −1}), algebraic approximants gave accurate values of energy levels, which were in excellent agreement with the variational method. For highly excited states, strong and multiple resonances complicate series resummation, but a suitable change of normal mode frequencies allows one to reduce the resonance mixing and to get accurate energy levels. The theoretical background of the problem of RSPT series divergence is discussed along with its numerical analysis. For these purposes, the vibrational energy is considered as a function of a complex perturbation parameter. Layout and classification of its singularities allow us to model the asymptotic behavior of the perturbation series and prove the robustness of the algorithm.

  5. Fringe Analysis around an Inclined Crack Tip of Finite-Width Plate under Tensile Load by Photoelastic Phase-Shifting Method

    Li, Weizheng; Baek, Tae Hyun; Lee, Byung Hee; Seo, Jin; Hong, Dong Pyo

    2012-01-01

    Photoelasticity is a technique of experimental methods and has been widely used in various domains of engineering to determine the stress distribution of structures. Without complicated mathematical formulation, this technique can conveniently provide a fairly accurate whole-field stress analysis for a mechanical structure. Here, stress distribution around an inclined crack tip of finite-width plate is studied by 8-step phase-shifting method. This method is a kind of photoelastic phase-shifting techniques and can be used for the determination of the phase values of isochromatics and isoclinics. According to stress-optic law, the stress distribution could be obtained from fringe patterns. The results obtained by polariscope arrangement combined with 8-step method and ABAQUS FEM simulations are compared with each other. Good agreement between them shows that 8-step phase-shifting method is reliable and can be used for determination of stress by experiment

  6. Schroedinger operators with singular perturbation potentials

    Harrell, E.M. II.

    1976-01-01

    This is a perturbative analysis of the eigenvalues and eigenfunctions of Schroedinger operators of the form -Δ + A + lambda V, defined on the Hilbert space L 2 (R/sup n/). A is a potential function (a smooth, real multiplication operator), and V is a ''spikelike'' perturbation, i.e., a perturbative potential function which diverges at some finite point. Lambda is a small real or complex parameter. The emphasis is on one-dimensional problems, and in particular the typical example is the ''spiked harmonic oscillator'' Hamiltonian, -d 2 /dx 2 + x 2 + lambda x/sup -α/, where α is a positive constant. An earlier study by L. Detwiler and J. R. Klauder [Phys. Rev. D 11 (1975) 1436] indicated that the lowest-order corrections to the ground-state eigenvalue of the spiked harmonic oscillator with lambda greater than 0 were proportional to lambda ln lambda when α = 3, and to lambda/sup 1/(α-2) when α is greater than 3. These and analogous results for a large class of operators and arbitrary eigenvalues are proved. Explicit constants in a modified perturbation series with a complicated dependence on lambda are determined and exhibited. Higher-order corrections for real lambda and lowest-order corrections for complex lambda are also discussed. While the substance of the dissertation is mathematical, its main applications are to quantum physics. The immediate cause of interest in such problems was the use of their peculiar convergence properties by J. R. Klauder as models for the behavior of nonrenormalizable quantum field theories. However, the results of this study are likely to be of greater importance in chemical or nuclear physics, as positive spikelike perturbations represent repulsive core interactions for quantum mechanical particles. The modified perturbation series are a new calculation technique for this situation

  7. Chiral perturbation theory

    Harada, Masayasu

    2009-01-01

    Chiral perturbation theory has been used for great number of phenomenological analyses in low energy QCD as well as the lattice QCD analyses since the creation of the theory by Weinberg in 1979 followed by its consolidation by Gasser and Leutwyler in 1984 and 85. The theory is now the highly established one as the approach based on the effective field theory to search for Green function including quantum correlations in the frame of the systematic expansion technique using Lagrangian which includes all of the terms allowed by the symmetry. This review has been intended to describe how systematically physical quantities are calculated in the framework of the chiral symmetry. Consequently many of the various phenomenological analyses are not taken up here for which other reports are to be referred. Further views are foreseen to be developed based on the theory in addition to numbers of results reported up to the present. Finally π-π scattering is taken up to discuss to what energy scale the theory is available. (S. Funahashi)

  8. Perturbed angular correlation

    Fabris, J.D.

    1977-01-01

    The electric quadrupolar interaction in some hafnium complexes, measured at the metal nucleus level is studied. For that purpose, the technique of γ-γ perturbed angular correlation is used: the frequencies of quadrupolar interaction are compared with some hafnium α-hydroxicarboxilates, namely glycolate, lactate, mandelate and benzylate; the influence of the temperature on the quadrupolar coupling on the hafnium tetramandelate is studied; finally, the effects associated with the capture of thermal neutrons by hafnium tetramandelate are examined locally at the nuclear level. The first group of results shows significant differences in a series of complexes derived from glycolic acid. On the other hand, the substitution of the protons in hafnium tetramandelate structure by some alkaline cations permits to verify a correlation between the variations in the quadrupolar coupling and the electronegativities of the substituent elements. Measurements at high temperatures show that this complex is thermally stable at 100 and 150 0 C. It is possible to see the appearance of two distinct sites for the probe nucleus, after heating the sample at 100 0 C for prolonged time. This fact is attributed to a probable interconversion among the postulated structural isomers for the octacoordinated compounds. Finally, measurements of angular correlation on the irradiated complex show that there is an effective destruction of the target molecule by neutron capture [pt

  9. Perturbative quantum chromodynamics

    Brodsky, S.J.

    1979-12-01

    The application of QCD to hadron dynamics at short distances, where asymptotic freedom allows a systematic perturbative approach, is addressed. The main theme of the approach is to incorporate systematically the effects of the hadronic wave function in large momentum transfer exclusive and inclusive reactions. Although it is conventional to treat the hadron as a classical source of on-shell quarks, there are important dynamical effects due to hadronic constituent structure which lead to a broader testing ground for QCD. QCD predictions are discussed for exclusive processes and form factors at large momentum transfer in which the short-distance behavior and the finite compositeness of the hadronic wave functions play crucial roles. Many of the standard tests of QCD are reviewed including the predictions for R = sigma/sub e + e - →had//sigma/sub e + e - →μ + μ - /, the structure functions of hadrons and photons, jet phenomena, and the QCD corrections to deep inelastic processes. The exclusive-inclusive connection in QCD, the effects of power-law scale-breaking contributions, and the important role of the available energy in controlling logarithmic scale violations are also discussed. 150 references, 44 figures

  10. Lattice regularized chiral perturbation theory

    Borasoy, Bugra; Lewis, Randy; Ouimet, Pierre-Philippe A.

    2004-01-01

    Chiral perturbation theory can be defined and regularized on a spacetime lattice. A few motivations are discussed here, and an explicit lattice Lagrangian is reviewed. A particular aspect of the connection between lattice chiral perturbation theory and lattice QCD is explored through a study of the Wess-Zumino-Witten term

  11. Perturbative QCD (1/3)

    CERN. Geneva

    2013-01-01

    Perturbative QCD is the general theoretical framework for describing hard scattering processes yielding multiparticle production at hadron colliders. In these lectures, we shall introduce fundamental features of perturbative QCD and describe its application to several high energy collider processes, including jet production in electron-positron annihilation, deep inelastic scattering, Higgs boson and gauge boson production at the LHC.

  12. Propagation of Ion Acoustic Perturbations

    Pécseli, Hans

    1975-01-01

    Equations describing the propagation of ion acoustic perturbations are considered, using the assumption that the electrons are Boltzman distributed and isothermal at all times. Quasi-neutrality is also considered.......Equations describing the propagation of ion acoustic perturbations are considered, using the assumption that the electrons are Boltzman distributed and isothermal at all times. Quasi-neutrality is also considered....

  13. On summation of perturbation expansions

    Horzela, A.

    1985-04-01

    The problem of the restoration of physical quantities defined by divergent perturbation expansions is analysed. The Pad'e and Borel summability is proved for alternating perturbation expansions with factorially growing coefficients. The proof is based on the methods of the classical moments theory. 17 refs. (author)

  14. Continual integral in perturbation theory

    Slavnov, A.A.

    1975-01-01

    It is shown that all results obtained by means of continual integration within the framework of perturbation theory are completely equivalent to those obtained by the usual diagram technique and are therfore just as rigorous. A rigorous justification is given for the rules for operating with continual integrals in perturbation theory. (author)

  15. Stress analysis in the neighborhood around a hole in a tensile plate by photoelastic phase shifting method

    Lee, Chun Bae; Jung, Girl; Park, Tae Geun; Yang, Min Bok; Kim, Myung Soo; Baek, Tae Hyun [Kunsan National University, Kunsan (Korea, Republic of)

    2005-05-15

    This paper presents the experimental distributions of isochromatic fringes obtained in a quadrate plate which has a hole at its center. Isochromatic fringe are measured by the use of Tardy compensation method and phase shifting technique, and they are compared with those obtained from finite element method. Tardy compensation method is a conventional method and widely used but it is time-costing and inaccurate to obtain the movement of isoclinic fringe on a given point. Therefore, the 8-step phase shifting methodology is introduced and applied in this paper.

  16. Stress analysis in the neighborhood around a hole in a tensile plate by photoelastic phase shifting method

    Lee, Chun Bae; Jung, Girl; Park, Tae Geun; Yang, Min Bok; Kim, Myung Soo; Baek, Tae Hyun

    2005-01-01

    This paper presents the experimental distributions of isochromatic fringes obtained in a quadrate plate which has a hole at its center. Isochromatic fringe are measured by the use of Tardy compensation method and phase shifting technique, and they are compared with those obtained from finite element method. Tardy compensation method is a conventional method and widely used but it is time-costing and inaccurate to obtain the movement of isoclinic fringe on a given point. Therefore, the 8-step phase shifting methodology is introduced and applied in this paper.

  17. Night Shift Work Increases the Risks of Multiple Primary Cancers in Women: A Systematic Review and Meta-analysis of 61 Articles.

    Yuan, Xia; Zhu, Chenjing; Wang, Manni; Mo, Fei; Du, Wei; Ma, Xuelei

    2018-01-01

    A growing number of studies have examined associations between night shift work and the risks of common cancers among women, with varying conclusions. We did a meta-analysis to identify whether long-term night shift work increased the risks of common cancers in women. We enrolled 61 articles involving 114,628 cases and 3,909,152 participants from Europe, North America, Asia, and Australia. Risk estimates were performed with a random-effect model or a fixed-effect model. Subgroup analyses and meta-regression analyses about breast cancer were conducted to explore possible sources of heterogeneity. In addition, we carried out a dose-response analysis to quantitatively estimate the accumulative effect of night shift work on the risk of breast cancer. A positive relationship was revealed between long-term night shift work and the risks of breast [OR = 1.316; 95% confidence interval (CI), 1.196-1.448], digestive system (OR = 1.177; 95% CI, 1.065-1.301), and skin cancer (OR = 1.408; 95% CI, 1.024-1.934). For every 5 years of night shift work, the risk of breast cancer in women was increased by 3.3% (OR = 1.033; 95% CI, 1.012-1.056). Concerning the group of nurses, long-term night shift work presented potential carcinogenic effect in breast cancer (OR = 1.577; 95% CI, 1.235-2.014), digestive system cancer (OR = 1.350; 95% CI, 1.030-1.770), and lung cancer (OR = 1.280; 95% CI, 1.070-1.531). This systematic review confirmed the positive association between night shift work and the risks of several common cancers in women. We identified that cancer risk of women increased with accumulating years of night shift work, which might help establish and implement effective measures to protect female night shifters. Cancer Epidemiol Biomarkers Prev; 27(1); 25-40. ©2018 AACR . ©2018 American Association for Cancer Research.

  18. The Impact of Shift Work on Brazilian Train Drivers with Different Chronotypes: A Comparative Analysis through Objective and Subjective Criteria

    de Araújo Fernandes Jr., Silvio; Stetner Antonietti, Leandro; Saba, Amanda; Paulino de Faria, Alexandre; Maculano Esteves, Andrea; Tufik, Sergio; Túlio de Mello, Marco

    2013-01-01

    Objective The aim of this study was to compare sleep pattern, tiredness sensation and quality of life between different chronotypes in train drivers from a Brazilian transportation company. Subjects and Methods Ninety-one train drivers, working a rotary work schedule including night shift, were divided into three groups according to their chronotype (morning types, intermediate or evening types) and were assessed for their sleep and quality of life, as characterized by a subjective questionnaire and the Psychomotor Vigilance Task (PVT), applied before and immediately after the night shift. The pattern of activity and rest was measured for 10 days by actigraphy, and the chronotype was determined through the Morningness-Eveningness Questionnaire. Results Forty-one (45.1s%) individuals were classified as morning type, 44 (48.4s%) were classified as intermediate and 6 (6.6s%) as evening type. The evening types had a tendency to remain awake for a longer period of time before the night shift (p = 0.05) and scored worse overall for quality of life compared to morning types (p = 0.11). There was no significant difference between the groups regarding variability in the PVT performance, even when covaried by the period of waking time before the test. There was no significant difference either in feelings of fatigue before and after starting the shift. Conclusion Although the evening type number was small, evening type individuals scored worse relative to sleep and quality of life than morning type individuals. PMID:23328130

  19. A double perturbation method of postbuckling analysis in 2D curved beams for assembly of 3D ribbon-shaped structures

    Fan, Zhichao; Hwang, Keh-Chih; Rogers, John A.; Huang, Yonggang; Zhang, Yihui

    2018-02-01

    Mechanically-guided 3D assembly based on controlled, compressive buckling represents a promising, emerging approach for forming complex 3D mesostructures in advanced materials. Due to the versatile applicability to a broad set of material types (including device-grade single-crystal silicon) over length scales from nanometers to centimeters, a wide range of novel applications have been demonstrated in soft electronic systems, interactive bio-interfaces as well as tunable electromagnetic devices. Previously reported 3D designs relied mainly on finite element analyses (FEA) as a guide, but the massive numerical simulations and computational efforts necessary to obtain the assembly parameters for a targeted 3D geometry prevent rapid exploration of engineering options. A systematic understanding of the relationship between a 3D shape and the associated parameters for assembly requires the development of a general theory for the postbuckling process. In this paper, a double perturbation method is established for the postbuckling analyses of planar curved beams, of direct relevance to the assembly of ribbon-shaped 3D mesostructures. By introducing two perturbation parameters related to the initial configuration and the deformation, the highly nonlinear governing equations can be transformed into a series of solvable, linear equations that give analytic solutions to the displacements and curvatures during postbuckling. Systematic analyses of postbuckling in three representative ribbon shapes (sinusoidal, polynomial and arc configurations) illustrate the validity of theoretical method, through comparisons to the results of experiment and FEA. These results shed light on the relationship between the important deformation quantities (e.g., mode ratio and maximum strain) and the assembly parameters (e.g., initial configuration and the applied strain). This double perturbation method provides an attractive route to the inverse design of ribbon-shaped 3D geometries, as

  20. Task shifting of HIV/AIDS case management to Community Health Service Centers in urban China: a qualitative policy analysis.

    Ma, Fuchang; Lv, Fan; Xu, Peng; Zhang, Dapeng; Meng, Sining; Ju, Lahong; Jiang, Huihui; Ma, Liping; Sun, Jiangping; Wu, Zunyou

    2015-07-02

    The growing number of people living with HIV/AIDS (PLWHA) in China points to an increased need for case management services of HIV/AIDS. This study sought to explore the challenges and enablers in shifting the HIV/AIDS case management services from Centers for Disease Control and Prevention (CDCs) to Community Health Service Centers (CHSCs) in urban China. A qualitative method based on the Health Policy Triangle (HPT) framework was employed to gain in-depth insights into four elements of the task shifting strategy. This included a review on published literature and health policy documents, 15 focus group discussions (FGDs) and 30 in-depth interviews (IDIs) with four types of key actors from three cities in China. A total of 78 studies and 17 policy files at the national, municipal and local levels were obtained and reviewed comprehensively. Three semi-structured interview guides were used to explore key actors' views on shifting the HIV/AIDS case management services to CHSCs. It is necessary and feasible for CHSCs to engage in case management services for PLWHA in local communities. The increasing number of PLWHA and shortage of qualified health professionals in CDCs made shifting case management services downwards to CHSCs an urgent agenda. CHSCs' wide distribution, technical capacity, accessibility and current practice enabled them to carry out case management services for PLWHA. However our findings indicated several challenges in this task shifting process. Those challenges included lack of specific policy and stable financial support for CHSCs, inadequate manpower, relatively low capacity for health service delivery, lack of coordination among sectors, PLWHA's fear for discrimination and privacy disclosure in local communities, which may compromise the effectiveness and sustainability of those services. Shifting the HIV/AIDS case management services from CDCs to CHSCs is a new approach to cope with the rising number of PLWHA in China, but it should be

  1. Application of the perturbation theory-differential formalism-for sensitivity analysis in steam generators of PWR type nuclear power plants

    Sanders, R.M.G.; Andrade Lima, F.R. de; Alvim, A.C.M.

    1987-06-01

    An homogeneous model which simulates the stationary behavior of steam generators of PWR type reactors and uses the differential formalism of perturbation theory for analysing sensibility of linear and non-linear responses, is presented. The PERGEVAP computer code to calculate the temperature distribution in the steam generator and associated importance function, is developed. The code also evaluates effects of the thermohydraulic parameter variation on selected functionals. The obtained results are compared with results obtained by GEVAP computer code . (M.C.K.) [pt

  2. Simulation and analysis of an isolated full-bridge DC/DC boost converter operating with a modified perturb and observe maximum power point tracking algorithm

    Calebe A. Matias

    2017-07-01

    Full Text Available The purpose of the present study is to simulate and analyze an isolated full-bridge DC/DC boost converter, for photovoltaic panels, running a modified perturb and observe maximum power point tracking method. The zero voltage switching technique was used in order to minimize the losses of the converter for a wide range of solar operation. The efficiency of the power transfer is higher than 90% for large solar operating points. The panel enhancement due to the maximum power point tracking algorithm is 5.06%.

  3. Pion-nucleon scattering in covariant baryon chiral perturbation theory with explicit Delta resonances

    Yao, De-Liang [Institute for Advanced Simulation, Institut für Kernphysik and Jülich Center for Hadron Physics,Forschungszentrum Jülich, D-52425 Jülich (Germany); Siemens, D. [Institut für Theoretische Physik II, Ruhr-Universität Bochum, D-44780 Bochum (Germany); Bernard, V. [Groupe de Physique Théorique, Institut de Physique Nucléaire, UMR 8606,CNRS, University Paris-Sud, Université Paris-Saclay, 91405 Orsay Cedex (France); Epelbaum, E. [Institut für Theoretische Physik II, Ruhr-Universität Bochum, D-44780 Bochum (Germany); Gasparyan, A.M. [Institut für Theoretische Physik II, Ruhr-Universität Bochum, D-44780 Bochum (Germany); SSC RF ITEP, Bolshaya Cheremushkinskaya 25, 117218 Moscow (Russian Federation); Gegelia, J. [Institute for Advanced Simulation, Institut für Kernphysik and Jülich Center for Hadron Physics,Forschungszentrum Jülich, D-52425 Jülich (Germany); Tbilisi State University, 0186 Tbilisi (Georgia); Krebs, H. [Institut für Theoretische Physik II, Ruhr-Universität Bochum, D-44780 Bochum (Germany); Meißner, Ulf-G. [Helmholtz Institut für Strahlen- und Kernphysik andBethe Center for Theoretical Physics, Universität Bonn, D-53115 Bonn (Germany); Institute for Advanced Simulation, Institut für Kernphysik and Jülich Center for Hadron Physics,Forschungszentrum Jülich, D-52425 Jülich (Germany)

    2016-05-05

    We present the results of a third order calculation of the pion-nucleon scattering amplitude in a chiral effective field theory with pions, nucleons and delta resonances as explicit degrees of freedom. We work in a manifestly Lorentz invariant formulation of baryon chiral perturbation theory using dimensional regularization and the extended on-mass-shell renormalization scheme. In the delta resonance sector, the on mass-shell renormalization is realized as a complex-mass scheme. By fitting the low-energy constants of the effective Lagrangian to the S- and P-partial waves a satisfactory description of the phase shifts from the analysis of the Roy-Steiner equations is obtained. We predict the phase shifts for the D and F waves and compare them with the results of the analysis of the George Washington University group. The threshold parameters are calculated both in the delta-less and delta-full cases. Based on the determined low-energy constants, we discuss the pion-nucleon sigma term. Additionally, in order to determine the strangeness content of the nucleon, we calculate the octet baryon masses in the presence of decuplet resonances up to next-to-next-to-leading order in SU(3) baryon chiral perturbation theory. The octet baryon sigma terms are predicted as a byproduct of this calculation.

  4. Acute alcohol effects on set-shifting and its moderation by baseline individual differences: a latent variable analysis.

    Korucuoglu, Ozlem; Sher, Kenneth J; Wood, Phillip K; Saults, John Scott; Altamirano, Lee; Miyake, Akira; Bartholow, Bruce D

    2017-03-01

    To compare the acute effects of alcohol on set-shifting task performance (relative to sober baseline performance) during ascending and descending limb breath alcohol concentration (BrAC), as well as possible moderation of these effects by baseline individual differences. Shifting performance was tested during an initial baseline and a subsequent drinking session, during which participants were assigned randomly to one of three beverage conditions (alcohol, placebo or control) and one of two BrAC limb conditions [ascending and descending (A/D) or descending-only (D-only)]. A human experimental laboratory on the University of Missouri campus in Columbia, MO, USA. A total of 222 moderate-drinking adults (ages 21-30 years) recruited from Columbia, MO and tested between 2010 and 2013. The outcome measure was performance on set-shifting tasks under the different beverage and limb conditions. Shifting performance assessed at baseline was a key moderator. Although performance improved across sessions, this improvement was reduced in the alcohol compared with no-alcohol groups (post-drink latent mean comparison across groups, all Ps ≤ 0.05), and this effect was more pronounced in individuals with lower pre-drink performance (comparison of pre- to post-drink path coefficients across groups, all Ps ≤ 0.05). In the alcohol group, performance was better on descending compared with ascending limb (P ≤ 0.001), but descending limb performance did not differ across the A/D and D-only groups. Practising tasks before drinking moderates the acute effects of alcohol on the ability to switch between tasks. Greater impairment in shifting ability on descending compared with ascending breath alcohol concentration is not related to task practice. © 2016 Society for the Study of Addiction.

  5. Diagnostic shift in patients diagnosed with schizoaffective disorder: a systematic review and meta-analysis of rediagnosis studies.

    Santelmann, Hanno; Franklin, Jeremy; Bußhoff, Jana; Baethge, Christopher

    2016-05-01

    The diagnosis of schizoaffective disorder (SAD) is well established in clinical practice but is heavily disputed on theoretical grounds. We analyzed the extent and direction of diagnostic shift in SAD patients. We searched Medline, Embase, and PsycINFO systematically for all studies documenting two diagnostic assessments at different points in time (rediagnosis studies) and used meta-analytic methods to quantify diagnostic shift. Multiple prespecified and post-hoc subgroup analyses (e.g., rater blinding) and meta-regressions (e.g., year of publication) were carried out. We included 31 studies out of 4,415 articles screened: 27 studies on the shift from and 23 studies on the shift to SAD (median time span was two years). A total of 36% of patients with a diagnosis of SAD at first assessment switch, many to schizophrenia (19%), 14% to affective disorders, and 6% to other disorders. Among patients diagnosed with SAD at second assessment, 55% had received a different diagnosis at first assessment, a large portion of whom had been initially diagnosed with affective disorder (24%), schizophrenia (18%), and other disorders (12%). Diagnostic shift in SAD patients is substantial. Psychiatrists need to reassess the diagnosis during the course of the illness and to adjust treatment. Slightly more diagnoses of SAD are changed to schizophrenia than to affective disorders, and among patients rediagnosed with SAD, fewer have been diagnosed with schizophrenia than with affective disorders. Thus, at the diagnostic level, there seems to be a slight trend toward schizophrenia during the course of functional psychoses. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  6. Disformal transformation of cosmological perturbations

    Masato Minamitsuji

    2014-10-01

    Full Text Available We investigate the gauge-invariant cosmological perturbations in the gravity and matter frames in the general scalar–tensor theory where two frames are related by the disformal transformation. The gravity and matter frames are the extensions of the Einstein and Jordan frames in the scalar–tensor theory where two frames are related by the conformal transformation, respectively. First, it is shown that the curvature perturbation in the comoving gauge to the scalar field is disformally invariant as well as conformally invariant, which gives the predictions from the cosmological model where the scalar field is responsible both for inflation and cosmological perturbations. Second, in case that the disformally coupled matter sector also contributes to curvature perturbations, we derive the evolution equations of the curvature perturbation in the uniform matter energy density gauge from the energy (nonconservation in the matter sector, which are independent of the choice of the gravity sector. While in the matter frame the curvature perturbation in the uniform matter energy density gauge is conserved on superhorizon scales for the vanishing nonadiabatic pressure, in the gravity frame it is not conserved even if the nonadiabatic pressure vanishes. The formula relating two frames gives the amplitude of the curvature perturbation in the matter frame, once it is evaluated in the gravity frame.

  7. Disformal transformation of cosmological perturbations

    Minamitsuji, Masato

    2014-01-01

    We investigate the gauge-invariant cosmological perturbations in the gravity and matter frames in the general scalar–tensor theory where two frames are related by the disformal transformation. The gravity and matter frames are the extensions of the Einstein and Jordan frames in the scalar–tensor theory where two frames are related by the conformal transformation, respectively. First, it is shown that the curvature perturbation in the comoving gauge to the scalar field is disformally invariant as well as conformally invariant, which gives the predictions from the cosmological model where the scalar field is responsible both for inflation and cosmological perturbations. Second, in case that the disformally coupled matter sector also contributes to curvature perturbations, we derive the evolution equations of the curvature perturbation in the uniform matter energy density gauge from the energy (non)conservation in the matter sector, which are independent of the choice of the gravity sector. While in the matter frame the curvature perturbation in the uniform matter energy density gauge is conserved on superhorizon scales for the vanishing nonadiabatic pressure, in the gravity frame it is not conserved even if the nonadiabatic pressure vanishes. The formula relating two frames gives the amplitude of the curvature perturbation in the matter frame, once it is evaluated in the gravity frame

  8. CIRCUMSTELLAR DEBRIS DISKS: DIAGNOSING THE UNSEEN PERTURBER

    Nesvold, Erika R. [Department of Terrestrial Magnetism, Carnegie Institution for Science, 5241 Broad Branch Rd., Washington, DC 20015 (United States); Naoz, Smadar; Vican, Laura [Department of Physics and Astronomy, UCLA, 475 Portola Plaza, Los Angeles, CA 90095 (United States); Farr, Will M. [School of Physics and Astronomy, University of Birmingham, Birmingham, B15 2TT (United Kingdom)

    2016-07-20

    The first indication of the presence of a circumstellar debris disk is usually the detection of excess infrared emission from the population of small dust grains orbiting the star. This dust is short-lived, requiring continual replenishment, and indicating that the disk must be excited by an unseen perturber. Previous theoretical studies have demonstrated that an eccentric planet orbiting interior to the disk will stir the larger bodies in the belt and produce dust via interparticle collisions. However, motivated by recent observations, we explore another possible mechanism for heating a debris disk: a stellar-mass perturber orbiting exterior to and inclined to the disk and exciting the disk particles’ eccentricities and inclinations via the Kozai–Lidov mechanism. We explore the consequences of an exterior perturber on the evolution of a debris disk using secular analysis and collisional N -body simulations. We demonstrate that a Kozai–Lidov excited disk can generate a dust disk via collisions and we compare the results of the Kozai–Lidov excited disk with a simulated disk perturbed by an interior eccentric planet. Finally, we propose two observational tests of a dust disk that can distinguish whether the dust was produced by an exterior brown dwarf or stellar companion or an interior eccentric planet.

  9. Effective field theory of cosmological perturbations

    Piazza, Federico; Vernizzi, Filippo

    2013-01-01

    The effective field theory of cosmological perturbations stems from considering a cosmological background solution as a state displaying spontaneous breaking of time translations and (adiabatic) perturbations as the related Nambu–Goldstone modes. With this insight, one can systematically develop a theory for the cosmological perturbations during inflation and, with minor modifications, also describe in full generality the gravitational interactions of dark energy, which are relevant for late-time cosmology. The formalism displays a unique set of Lagrangian operators containing an increasing number of cosmological perturbations and derivatives. We give an introductory description of the unitary gauge formalism for theories with broken gauge symmetry—that allows us to write down the most general Lagrangian—and of the Stückelberg ‘trick’—that allows to recover gauge invariance and to make the scalar field explicit. We show how to apply this formalism to gravity and cosmology and we reproduce the detailed analysis of the action in the ADM variables. We also review some basic applications to inflation and dark energy. (paper)

  10. Privacy Is Become with, Data Perturbation

    Singh, Er. Niranjan; Singhai, Niky

    2011-06-01

    Privacy is becoming an increasingly important issue in many data mining applications that deal with health care, security, finance, behavior and other types of sensitive data. Is particularly becoming important in counterterrorism and homeland security-related applications. We touch upon several techniques of masking the data, namely random distortion, including the uniform and Gaussian noise, applied to the data in order to protect it. These perturbation schemes are equivalent to additive perturbation after the logarithmic Transformation. Due to the large volume of research in deriving private information from the additive noise perturbed data, the security of these perturbation schemes is questionable Many artificial intelligence and statistical methods exist for data analysis interpretation, Identifying and measuring the interestingness of patterns and rules discovered, or to be discovered is essential for the evaluation of the mined knowledge and the KDD process as a whole. While some concrete measurements exist, assessing the interestingness of discovered knowledge is still an important research issue. As the tool for the algorithm implementations we chose the language of choice in industrial world MATLAB.

  11. Mechanical perturbation control of cardiac alternans

    Hazim, Azzam; Belhamadia, Youssef; Dubljevic, Stevan

    2018-05-01

    Cardiac alternans is a disturbance in heart rhythm that is linked to the onset of lethal cardiac arrhythmias. Mechanical perturbation control has been recently used to suppress alternans in cardiac tissue of relevant size. In this control strategy, cardiac tissue mechanics are perturbed via active tension generated by the heart's electrical activity, which alters the tissue's electric wave profile through mechanoelectric coupling. We analyze the effects of mechanical perturbation on the dynamics of a map model that couples the membrane voltage and active tension systems at the cellular level. Therefore, a two-dimensional iterative map of the heart beat-to-beat dynamics is introduced, and a stability analysis of the system of coupled maps is performed in the presence of a mechanical perturbation algorithm. To this end, a bidirectional coupling between the membrane voltage and active tension systems in a single cardiac cell is provided, and a discrete form of the proposed control algorithm, that can be incorporated in the coupled maps, is derived. In addition, a realistic electromechanical model of cardiac tissue is employed to explore the feasibility of suppressing alternans at cellular and tissue levels. Electrical activity is represented in two detailed ionic models, the Luo-Rudy 1 and the Fox models, while two active contractile tension models, namely a smooth variant of the Nash-Panfilov model and the Niederer-Hunter-Smith model, are used to represent mechanical activity in the heart. The Mooney-Rivlin passive elasticity model is employed to describe passive mechanical behavior of the myocardium.

  12. Effective field theory of cosmological perturbations

    Piazza, Federico; Vernizzi, Filippo

    2013-11-01

    The effective field theory of cosmological perturbations stems from considering a cosmological background solution as a state displaying spontaneous breaking of time translations and (adiabatic) perturbations as the related Nambu-Goldstone modes. With this insight, one can systematically develop a theory for the cosmological perturbations during inflation and, with minor modifications, also describe in full generality the gravitational interactions of dark energy, which are relevant for late-time cosmology. The formalism displays a unique set of Lagrangian operators containing an increasing number of cosmological perturbations and derivatives. We give an introductory description of the unitary gauge formalism for theories with broken gauge symmetry—that allows us to write down the most general Lagrangian—and of the Stückelberg ‘trick’—that allows to recover gauge invariance and to make the scalar field explicit. We show how to apply this formalism to gravity and cosmology and we reproduce the detailed analysis of the action in the ADM variables. We also review some basic applications to inflation and dark energy.

  13. Exergy analysis of a hydrogen fired combined cycle with natural gas reforming and membrane assisted shift reactors for CO2 capture

    Atsonios, K.; Panopoulos, K.D.; Doukelis, A.; Koumanakos, A.; Kakaras, Em.

    2012-01-01

    Highlights: ► Exergy analysis of NGCC with CCS. ► WGS-MR: exergetically efficient technology for CCS, less than 2% total exergy losses. ► 10% of total exergy dissipation in the ATR. ► Optimization of ATR operation and CO 2 stream treatment. - Abstract: Hydrogen production from fossil fuels together with carbon capture has been suggested as a means of providing a carbon free power. The paper presents a comparative exergetic analysis performed on the hydrogen production from natural gas with several combinations of reactor systems: (a) oxy or air fired autothermal reforming with subsequent water gas shift reactor and (b) membrane reactor assisted with shift catalysts. The influence of reactor temperature and pressure as well as operating parameter steam-to-carbon ratio, is also studied exergetically. The results indicate optimal power plant configurations with CO 2 capture, or hydrogen delivery for industrial applications.

  14. Nonperturbative Quantum Physics from Low-Order Perturbation Theory.

    Mera, Héctor; Pedersen, Thomas G; Nikolić, Branislav K

    2015-10-02

    The Stark effect in hydrogen and the cubic anharmonic oscillator furnish examples of quantum systems where the perturbation results in a certain ionization probability by tunneling processes. Accordingly, the perturbed ground-state energy is shifted and broadened, thus acquiring an imaginary part which is considered to be a paradigm of nonperturbative behavior. Here we demonstrate how the low order coefficients of a divergent perturbation series can be used to obtain excellent approximations to both real and imaginary parts of the perturbed ground state eigenenergy. The key is to use analytic continuation functions with a built-in singularity structure within the complex plane of the coupling constant, which is tailored by means of Bender-Wu dispersion relations. In the examples discussed the analytic continuation functions are Gauss hypergeometric functions, which take as input fourth order perturbation theory and return excellent approximations to the complex perturbed eigenvalue. These functions are Borel consistent and dramatically outperform widely used Padé and Borel-Padé approaches, even for rather large values of the coupling constant.

  15. Cosmological perturbations beyond linear order

    CERN. Geneva

    2013-01-01

    Cosmological perturbation theory is the standard tool to understand the formation of the large scale structure in the Universe. However, its degree of applicability is limited by the growth of the amplitude of the matter perturbations with time. This problem can be tackled with by using N-body simulations or analytical techniques that go beyond the linear calculation. In my talk, I'll summarise some recent efforts in the latter that ameliorate the bad convergence of the standard perturbative expansion. The new techniques allow better analytical control on observables (as the matter power spectrum) over scales very relevant to understand the expansion history and formation of structure in the Universe.

  16. Perturbation theory of effective Hamiltonians

    Brandow, B.H.

    1975-01-01

    This paper constitutes a review of the many papers which have used perturbation theory to derive ''effective'' or ''model'' Hamiltonians. It begins with a brief review of nondegenerate and non-many-body perturbation theory, and then considers the degenerate but non-many-body problem in some detail. It turns out that the degenerate perturbation problem is not uniquely defined, but there are some practical criteria for choosing among the various possibilities. Finally, the literature dealing with the linked-cluster aspects of open-shell many-body systems is reviewed. (U.S.)

  17. The theory of singular perturbations

    De Jager, E M

    1996-01-01

    The subject of this textbook is the mathematical theory of singular perturbations, which despite its respectable history is still in a state of vigorous development. Singular perturbations of cumulative and of boundary layer type are presented. Attention has been given to composite expansions of solutions of initial and boundary value problems for ordinary and partial differential equations, linear as well as quasilinear; also turning points are discussed. The main emphasis lies on several methods of approximation for solutions of singularly perturbed differential equations and on the mathemat

  18. The power of perturbation theory

    Serone, Marco [SISSA International School for Advanced Studies and INFN Trieste, Via Bonomea 265, 34136, Trieste (Italy); Abdus Salam International Centre for Theoretical Physics, Strada Costiera 11, 34151, Trieste (Italy); Spada, Gabriele [SISSA International School for Advanced Studies and INFN Trieste, Via Bonomea 265, 34136, Trieste (Italy); Villadoro, Giovanni [Abdus Salam International Centre for Theoretical Physics, Strada Costiera 11, 34151, Trieste (Italy)

    2017-05-10

    We study quantum mechanical systems with a discrete spectrum. We show that the asymptotic series associated to certain paths of steepest-descent (Lefschetz thimbles) are Borel resummable to the full result. Using a geometrical approach based on the Picard-Lefschetz theory we characterize the conditions under which perturbative expansions lead to exact results. Even when such conditions are not met, we explain how to define a different perturbative expansion that reproduces the full answer without the need of transseries, i.e. non-perturbative effects, such as real (or complex) instantons. Applications to several quantum mechanical systems are presented.

  19. Application of the Fenske-Hall molecular orbital method to the calculation of 11B NMR chemical shifts. Antipodal substituent effects in deltahedral clusters

    Fehlner, T.P.; Czech, P.T.; Fenske, R.F.

    1990-01-01

    Utilizing Fenske-Hall wave functions and eigenvalues combined with the Ramsey sum over states (SOS) approximation, it is demonstrated that the sign and magnitude of the paramagnetic contribution to the shielding correlates well with the observed 11 B chemical shifts of a substantial variety of boron- and metal-containing compounds. Analysis of the molecular orbital (MO) contributions in the SOS approximation leads to an explanation of the large downfield shifts associated with metal-rich metallaboranes. A similar analysis demonstrates the importance of selected cluster occupied and unoccupied MO's in explaining both exo-cage substituent effects in which the antipodal boron resonance is shifted upfield and endo-cage substituent effects (interchange of isolobal fragments within the cage framework) in which the antipodal boron resonance is shifted downfield. Exo- and endo-cage substitution perturbs these MO's in an understandable fashion, leading to an internally consistent explanation of the observed chemical shift changes. 36 refs., 8 figs., 4 tabs

  20. Tunnelling instability via perturbation theory

    Graffi, S. (Bologna Univ. (Italy). Dip. di Matematica); Grecchi, V. (Moderna Univ. (Italy). Dip. di Matematica); Jona-Lasinio, G. (Paris-11 Univ., 91 - Orsay (France). Lab. de Physique Theorique et Hautes Energies)

    1984-10-21

    The semiclassical limit of low lying states in a multiwell potential is studied by rigorous perturbative techniques. In particular tunnelling instability and localisation of wave functions is obtained in a simple way under small deformations of symmetric potentials.

  1. Perturbation theory of quantum resonances

    Durand, P.; Paidarová, Ivana

    2016-01-01

    Roč. 135, č. 7 (2016), s. 159 ISSN 1432-2234 Institutional support: RVO:61388955 Keywords : Partitioning technique * Analytic continuation * Perturbative expansion Subject RIV: CF - Physical ; Theoretical Chemistry

  2. Perturbation Theory of Embedded Eigenvalues

    Engelmann, Matthias

    project gives a general and systematic approach to analytic perturbation theory of embedded eigenvalues. The spectral deformation technique originally developed in the theory of dilation analytic potentials in the context of Schrödinger operators is systematized by the use of Mourre theory. The group...... of dilations is thereby replaced by the unitary group generated y the conjugate operator. This then allows to treat the perturbation problem with the usual Kato theory.......We study problems connected to perturbation theory of embedded eigenvalues in two different setups. The first part deals with second order perturbation theory of mass shells in massive translation invariant Nelson type models. To this end an expansion of the eigenvalues w.r.t. fiber parameter up...

  3. Perturbative tests of quantum chromodynamics

    Michael, C.

    1978-01-01

    A review is given of perturbation theory results for quantum chromodynamics and of tests in deep inelastic lepton scattering, electron-positron annihilation, hadronic production of massive dileptons and hadronic large-momentum-transfer processes. (author)

  4. Review of chiral perturbation theory

    Abstract. A review of chiral perturbation theory and recent developments on the comparison of its predictions with experiment is presented. Some interesting topics with scope for further elaboration are touched upon.

  5. Comparison of second-order impact line shifts

    Griem, H.R.; Iglesias, C.A.; Boercker, D.B.

    1991-01-01

    The second-order impact shifts in hydrogen obtained from the Baranger formalism are compared with those from a kinetic theory approach. The resulting Δn=0 contributions to the shift from the two theories are shown to be identical, except for the neglect of electron-electron correlations in the Baranger formalism. It is also shown that some care is required in taking the classical limit for the perturbing electrons, or else the shift from Δn=0 interactions vanishes

  6. A perturbation-based model for rectifier circuits

    Vipin B. Vats

    2006-01-01

    Full Text Available A perturbation-theoretic analysis of rectifier circuits is presented. The governing differential equation of the half-wave rectifier with capacitor filter is analyzed by expanding the output voltage as a Taylor series with respect to an artificially introduced parameter in the nonlinearity of the diode characteristic as is done in quantum theory. The perturbation parameter introduced in the analysis is independent of the circuit components as compared to the method presented by multiple scales. The various terms appearing in the perturbation series are then modeled in the form of an equivalent circuit. This model is subsequently used in the analysis of full-wave rectifier. Matlab simulation results are included which confirm the validity of the theoretical formulations. Perturbation analysis acts a helpful tool in analyzing time-varying systems and chaotic systems.

  7. Perturbation theory in light-cone gauge

    Vianello, Eliana

    2000-01-01

    Perturbation calculations are presented for the light-cone gauge Schwinger model. Eigenstates can be calculated perturbatively but the perturbation theory is nonstandard. We hope to extend the work to QCD 2 to resolve some outstanding issues in those theories

  8. Capillary and viscous perturbations to Helmholtz flows

    Moore, M. R.; Ockendon, H.; Ockendon, J. R.; Oliver, J. M.

    2014-01-01

    Inspired by recent calculations by Thoraval et al. (Phys. Rev. Lett., vol. 108, 2012, p. 264506) relating to droplet impact, this paper presents an analysis of the perturbations to the free surface caused by small surface tension and viscosity in steady Helmholtz flows. In particular, we identify the regimes in which appreciable vorticity can be shed from the boundary layer to the bulk flow. © 2014 Cambridge University Press.

  9. Capillary and viscous perturbations to Helmholtz flows

    Moore, M. R.

    2014-02-21

    Inspired by recent calculations by Thoraval et al. (Phys. Rev. Lett., vol. 108, 2012, p. 264506) relating to droplet impact, this paper presents an analysis of the perturbations to the free surface caused by small surface tension and viscosity in steady Helmholtz flows. In particular, we identify the regimes in which appreciable vorticity can be shed from the boundary layer to the bulk flow. © 2014 Cambridge University Press.

  10. Dynamical Analysis of a Class of Prey-Predator Model with Beddington-DeAngelis Functional Response, Stochastic Perturbation, and Impulsive Toxicant Input

    Feifei Bian

    2017-01-01

    Full Text Available A stochastic prey-predator system in a polluted environment with Beddington-DeAngelis functional response is proposed and analyzed. Firstly, for the system with white noise perturbation, by analyzing the limit system, the existence of boundary periodic solutions and positive periodic solutions is proved and the sufficient conditions for the existence of boundary periodic solutions and positive periodic solutions are derived. And then for the stochastic system, by introducing Markov regime switching, the sufficient conditions for extinction or persistence of such system are obtained. Furthermore, we proved that the system is ergodic and has a stationary distribution when the concentration of toxicant is a positive constant. Finally, two examples with numerical simulations are carried out in order to illustrate the theoretical results.

  11. Effect of a Perturbation on the Chemical Equilibrium: Comparison with Le Chatelier's Principle

    Torres, Emilio Martinez

    2007-01-01

    This article develops a general thermodynamic treatment to predict the direction of shift in a chemical equilibrium when it is subjected to a stress. This treatment gives an inequality that relates the change in the perturbed variable and the change that the equilibrium shift produces in the conjugated variable. To illustrate the generality of…

  12. Isotopic perturbation of degeneracy. Carbon-13 nuclear magnetic resonance spectra of dimethylcyclopentyl and dimethylnorbornyl cations

    Saunders, M.; Telkowski, L.; Kates, M.R.

    1977-01-01

    The large chemical shifts in 13 C NMR were used to measure the deuterium induced splittings and shifts in the 1 H NMR spectra of dimethylcyclopentyl and dimethylnorbornyl cations, where the deuterium perturbs the degenerate equilibrium. The isotope splitting obtained are tabulated

  13. Non-Perturbative Asymptotic Improvement of Perturbation Theory and Mellin-Barnes Representation

    Samuel Friot

    2010-10-01

    Full Text Available Using a method mixing Mellin-Barnes representation and Borel resummation we show how to obtain hyperasymptotic expansions from the (divergent formal power series which follow from the perturbative evaluation of arbitrary ''N-point'' functions for the simple case of zero-dimensional φ4 field theory. This hyperasymptotic improvement appears from an iterative procedure, based on inverse factorial expansions, and gives birth to interwoven non-perturbative partial sums whose coefficients are related to the perturbative ones by an interesting resurgence phenomenon. It is a non-perturbative improvement in the sense that, for some optimal truncations of the partial sums, the remainder at a given hyperasymptotic level is exponentially suppressed compared to the remainder at the preceding hyperasymptotic level. The Mellin-Barnes representation allows our results to be automatically valid for a wide range of the phase of the complex coupling constant, including Stokes lines. A numerical analysis is performed to emphasize the improved accuracy that this method allows to reach compared to the usual perturbative approach, and the importance of hyperasymptotic optimal truncation schemes.

  14. Reactivity effect breakdown calculations with deterministic and stochastic perturbations analysis – JEFF-3.1.1 to JEFF3.2T1 (BRC-2009 actinides application

    Morillon B.

    2013-03-01

    Full Text Available JEFF-3.1.1 is the reference nuclear data library in CEA for the design calculations of the next nuclear power plants. The validation of the new neutronics code systems is based on this library and changes in nuclear data should be looked at closely. Some new actinides evaluation files at high energies have been proposed by CEA/Bruyères-le-Chatel in 2009 and have been integrated in JEFF3.2T1 test release. For the new release JEFF-3.2, CEA will build new evaluation files for the actinides, which should be a combination of the new evaluated data coming from BRC-2009 in the high energy range and improvements or new evaluations in the resolved and unresolved resonance range from CEA-Cadarache. To prepare the building of these new files, benchmarking the BRC-2009 library in comparison with the JEFF-3.1.1 library was very important. The crucial points to evaluate were the improvements in the continuum range and the discrepancies in the resonance range. The present work presents for a selected set of benchmarks the discrepancies in the effective multiplication factor obtained while using the JEFF-3.1.1 or JEFF-3.2T1 library with the deterministic code package ERANOS/PARIS and the stochastic code TRIPOLI-4. They have both been used to calculate cross section perturbations or other nuclear data perturbations when possible. This has permittted to identify the origin of the discrepancies in reactivity calculations. In addition, this work also shows the importance of cross section processing validation. Actually, some fast neutron spectrum calculations have led to opposite tendancies between the deterministic code package and the stochastic code. Some particular nuclear data (MT=5 in ENDF terminology seem to be incompatible with the current MERGE or GECCO processing codes.

  15. Geometry of perturbed Gaussian states and quantum estimation

    Genoni, Marco G; Giorda, Paolo; Paris, Matteo G A

    2011-01-01

    We address the non-Gaussianity (nG) of states obtained by weakly perturbing a Gaussian state and investigate the relationships with quantum estimation. For classical perturbations, i.e. perturbations to eigenvalues, we found that the nG of the perturbed state may be written as the quantum Fisher information (QFI) distance minus a term depending on the infinitesimal energy change, i.e. it provides a lower bound to statistical distinguishability. Upon moving on isoenergetic surfaces in a neighbourhood of a Gaussian state, nG thus coincides with a proper distance in the Hilbert space and exactly quantifies the statistical distinguishability of the perturbations. On the other hand, for perturbations leaving the covariance matrix unperturbed, we show that nG provides an upper bound to the QFI. Our results show that the geometry of non-Gaussian states in the neighbourhood of a Gaussian state is definitely not trivial and cannot be subsumed by a differential structure. Nevertheless, the analysis of perturbations to a Gaussian state reveals that nG may be a resource for quantum estimation. The nG of specific families of perturbed Gaussian states is analysed in some detail with the aim of finding the maximally non-Gaussian state obtainable from a given Gaussian one. (fast track communication)

  16. Delineating social network data anonymization via random edge perturbation

    Xue, Mingqiang

    2012-01-01

    Social network data analysis raises concerns about the privacy of related entities or individuals. To address this issue, organizations can publish data after simply replacing the identities of individuals with pseudonyms, leaving the overall structure of the social network unchanged. However, it has been shown that attacks based on structural identification (e.g., a walk-based attack) enable an adversary to re-identify selected individuals in an anonymized network. In this paper we explore the capacity of techniques based on random edge perturbation to thwart such attacks. We theoretically establish that any kind of structural identification attack can effectively be prevented using random edge perturbation and show that, surprisingly, important properties of the whole network, as well as of subgraphs thereof, can be accurately calculated and hence data analysis tasks performed on the perturbed data, given that the legitimate data recipient knows the perturbation probability as well. Yet we also examine ways to enhance the walk-based attack, proposing a variant we call probabilistic attack. Nevertheless, we demonstrate that such probabilistic attacks can also be prevented under sufficient perturbation. Eventually, we conduct a thorough theoretical study of the probability of success of any}structural attack as a function of the perturbation probability. Our analysis provides a powerful tool for delineating the identification risk of perturbed social network data; our extensive experiments with synthetic and real datasets confirm our expectations. © 2012 ACM.

  17. Assessment of the effects of the Japanese shift to lead-free solders and its impact on material substitution and environmental emissions by a dynamic material flow analysis

    Fuse, Masaaki; Tsunemi, Kiyotaka

    2012-01-01

    Lead-free electronics has been extensively studied, whereas their adoption by society and their impact on material substitution and environmental emissions are not well understood. Through a material flow analysis (MFA), this paper explores the life cycle flows for solder-containing metals in Japan, which leads the world in the shift to lead-free solders in electronics. The results indicate that the shift has been progressing rapidly for a decade, and that substitutes for lead in solders, which include silver and copper, are still in the early life cycle stages. The results also show, however, that such substitution slows down during the late life cycle stages owing to long electronic product lifespans. This deceleration of material substitution in the solder life cycle may not only preclude a reduction in lead emissions to air but also accelerate an increase in silver emissions to air and water. As an effective measure against ongoing lead emissions, our scenario analysis suggests an aggressive recycling program for printed circuit boards that utilizes an existing recycling scheme. -- Highlights: ► We model the life cycle flows for solder-containing metals in Japan. ► The Japanese shift to lead-free solders progresses rapidly for a decade. ► Substitution for lead in solders slows down during the late life cycle stages. ► The deceleration of substitution precludes a reduction in lead emissions to air.

  18. Numerical analysis for trajectory controllability of a coupled multi-order fractional delay differential system via the shifted Jacobi method

    Priya, B. Ganesh; Muthukumar, P.

    2018-02-01

    This paper deals with the trajectory controllability for a class of multi-order fractional linear systems subject to a constant delay in state vector. The solution for the coupled fractional delay differential equation is established by the Mittag-Leffler function. The necessary and sufficient condition for the trajectory controllability is formulated and proved by the generalized Gronwall's inequality. The approximate trajectory for the proposed system is obtained through the shifted Jacobi operational matrix method. The numerical simulation of the approximate solution shows the theoretical results. Finally, some remarks and comments on the existing results of constrained controllability for the fractional dynamical system are also presented.

  19. All-optical Hilbert transformer based on a single phase-shifted fiber Bragg grating: design and analysis.

    Asghari, Mohammad H; Azaña, José

    2009-02-01

    A simple all-fiber design for implementing an all-optical temporal Hilbert transformer is proposed and numerically demonstrated. We show that an all-optical Hilbert transformer can be implemented using a uniform-period fiber Bragg grating (FBG) with a properly designed amplitude-only grating apodization profile incorporating a single pi phase shift in the middle of the grating length. All-optical Hilbert transformers capable of processing arbitrary optical waveforms with bandwidths up to a few hundreds of gigahertz can be implemented using feasible FBGs.

  20. Small-Signal Analysis of Single-Phase and Three-phase DC/AC and AC/DC PWM Converters with the Frequency-Shift Technique

    Blaabjerg, Frede; Aquila, A. Dell’; Liserre, Marco

    2004-01-01

    of dc/dc converters via a 50 Hz frequency-shift. The input admittance is calculated and measured for two study examples (a three-phase active rectifier and a single-phase photovoltaic inverter). These examples show that the purpose of a well designed controller for grid-connected converters......A systematic approach to study dc/ac and ac/dc converters without the use of synchronous transformation is proposed. The use of a frequency-shift technique allows a straightforward analysis of single-phase and three-phase systems. The study of dc/ac and of ac/dc converters is reported to the study...... is to minimize the input admittance in order to make the grid converter more robust to grid disturbance....

  1. Theoretical analysis of geometry and NMR isotope shift in hydrogen-bonding center of photoactive yellow protein by combination of multicomponent quantum mechanics and ONIOM scheme

    Kanematsu, Yusuke; Tachikawa, Masanori [Quantum Chemistry Division, Yokohama City University, Seto 22-2, Kanazawa-ku, Yokohama 236-0027 (Japan)

    2014-11-14

    Multicomponent quantum mechanical (MC-QM) calculation has been extended with ONIOM (our own N-layered integrated molecular orbital + molecular mechanics) scheme [ONIOM(MC-QM:MM)] to take account of both the nuclear quantum effect and the surrounding environment effect. The authors have demonstrated the first implementation and application of ONIOM(MC-QM:MM) method for the analysis of the geometry and the isotope shift in hydrogen-bonding center of photoactive yellow protein. ONIOM(MC-QM:MM) calculation for a model with deprotonated Arg52 reproduced the elongation of O–H bond of Glu46 observed by neutron diffraction crystallography. Among the unique isotope shifts in different conditions, the model with protonated Arg52 with solvent effect reasonably provided the best agreement with the corresponding experimental values from liquid NMR measurement. Our results implied the availability of ONIOM(MC-QM:MM) to distinguish the local environment around hydrogen bonds in a biomolecule.

  2. Flow cytometric analysis of mitotic cycle perturbation by chemical carcinogens in cultured epithelial cells. [Effects of benzo(a)pyrene-diol-epoxide on mitotic cycle of cultural mouse liver epithelial cells

    Pearlman, Andrew Leonard [Univ. of California, Berkeley, CA (United States)

    1978-08-01

    A system for kinetic analysis of mitotic cycle perturbation by various agents was developed and applied to the study of the mitotic cycle effects and dependency of the chemical carcinogen benzo(a)pyrene-diolepoxide, DE, upon a mouse lever epithelial cell line, NMuLi. The study suggests that the targets of DE action are not confined to DNA alone but may include cytoplasmic structures as well. DE was found to affect cells located in virtually every phase of the mitotic cycle, with cells that were actively synthesizing DNA showing the strongest response. However, the resulting perturbations were not confined to S-phase alone. DE slowed traversal through S-phase by about 40% regardless of the cycle phase of the cells exposed to it, and slowed traversal through G2M by about 50%. When added to G1 cells, DE delayed recruitment of apparently quiescent (G0) cells by 2 hours, and reduced the synchrony of the cohort of cells recruited into active proliferation. The kinetic analysis system consists of four elements: tissue culture methods for propagating and harvesting cell populations; an elutriation centrifugation system for bulk synchronization of cells in various phases of the mitotic cycle; a flow cytometer (FCM), coupled with appropriate staining protocols, to enable rapid analysis of the DNA distribution of any given cell population; and data reduction and analysis methods for extracting information from the DNA histograms produced by the FCM. The elements of the system are discussed. A mathematical analysis of DNA histograms obtained by FCM is presented. The analysis leads to the detailed implementation of a new modeling approach. The new modeling approach is applied to the estimation of cell cycle kinetic parameters from time series of DNA histograms, and methods for the reduction and interpretation of such series are suggested.

  3. Bound-state perturbation theory and annihilation effects in positronium

    Abbasabadi, A.; Repko, W.W.

    1987-01-01

    Working in Coulomb gauge and using the lowest-order equation proposed by Barbieri and Remiddi it is calculated, in the one-loop order of perturbation theory, the decay rate and the energy shift of the ground states of parapositronium and orthopositronium, respectively. Our result for the decay rate agrees with that of Harris and Brown. For contribution of one-photon-annihilation channel to the energy shift, it is confirmed the result of Karplus and Klein. These results are derived completely within the bound-state formalism and avoid the necessity of performing on-mass-shell wave function and vertex renormalization subtractions

  4. Computational analysis of perturbations in the post-fusion Dengue virus envelope protein highlights known epitopes and conserved residues in the Zika virus [version 2; referees: 3 approved

    Sandeep Chakraborty

    2016-09-01

    Full Text Available The dramatic transformation of the Zika virus (ZIKV from a relatively unknown virus to a pathogen generating global-wide panic has exposed the dearth of detailed knowledge about this virus. Decades of research in the related Dengue virus (DENV, finally culminating in a vaccine registered for use in endemic regions (CYD-TDV in three countries, provides key insights in developing strategies for tackling ZIKV, which has caused global panic to microcephaly and Guillain-Barre Syndrome. Dengue virus (DENV, a member of the family Flaviviridae, the causal agent of the self-limiting Dengue fever and the potentially fatal hemorrhagic fever/dengue shock syndrome, has been a scourge in tropical countries for many centuries. The recently solved structure of mature ZIKV (PDB ID:5IRE has provided key insights into the structure of the envelope (E and membrane (M proteins, the primary target of neutralizing antibodies. The previously established MEPP methodology compares two conformations of the same protein and identifies residues with significant spatial and electrostatic perturbations. In the current work, MEPP analyzed the pre-and post-fusion DENV type 2 envelope (E protein, and identified several known epitopes (His317, Tyr299, Glu26, Arg188, etc. (MEPPitope. These residues are overwhelmingly conserved in ZIKV and all DENV serotypes, and also enumerates residue pairs that undergo significant polarity reversal. Characterization of α-helices in E-proteins show that α1 is not conserved in the sequence space of ZIKV and DENV. Furthermore, perturbation of α1 in the post-fusion DENV structure includes a known epitope Asp215, a residue absent in the pre-fusion α1. A cationic β-sheet in the GAG-binding domain that is stereochemically equivalent in ZIKV and all DENV serotypes is also highlighted due to a residue pair (Arg286-Arg288 that has a significant electrostatic polarity reversal upon fusion. Finally, two highly conserved residues (Thr32 and Thr40, with

  5. Base case and perturbation scenarios

    Edmunds, T

    1998-10-01

    This report describes fourteen energy factors that could affect electricity markets in the future (demand, process, source mix, etc.). These fourteen factors are believed to have the most influence on the State's energy environment. A base case, or most probable, characterization is given for each of these fourteen factors over a twenty year time horizon. The base case characterization is derived from quantitative and qualitative information provided by State of California government agencies, where possible. Federal government databases are nsed where needed to supplement the California data. It is envisioned that a initial selection of issue areas will be based upon an evaluation of them under base case conditions. For most of the fourteen factors, the report identities possible perturbations from base case values or assumptions that may be used to construct additional scenarios. Only those perturbations that are plausible and would have a significant effect on energy markets are included in the table. The fourteen factors and potential perturbations of the factors are listed in Table 1.1. These perturbations can be combined to generate internally consist.ent. combinations of perturbations relative to the base case. For example, a low natural gas price perturbation should be combined with a high natural gas demand perturbation. The factor perturbations are based upon alternative quantitative forecasts provided by other institutions (the Department of Energy - Energy Information Administration in some cases), changes in assumptions that drive the quantitative forecasts, or changes in assumptions about the structure of the California energy markets. The perturbations are intended to be used for a qualitative reexamination of issue areas after an initial evaluation under the base case. The perturbation information would be used as a "tiebreaker;" to make decisions regarding those issue areas that were marginally accepted or rejected under the base case. Hf a

  6. Perturbation theory in large order

    Bender, C.M.

    1978-01-01

    For many quantum mechanical models, the behavior of perturbation theory in large order is strikingly simple. For example, in the quantum anharmonic oscillator, which is defined by -y'' + (x 2 /4 + ex 4 /4 - E) y = 0, y ( +- infinity) = 0, the perturbation coefficients, A/sub n/, in the expansion for the ground-state energy, E(ground state) approx. EPSILON/sub n = 0//sup infinity/ A/sub n/epsilon/sup n/, simplify dramatically as n → infinity: A/sub n/ approx. (6/π 3 )/sup 1/2/(-3)/sup n/GAMMA(n + 1/2). Methods of applied mathematics are used to investigate the nature of perturbation theory in quantum mechanics and show that its large-order behavior is determined by the semiclassical content of the theory. In quantum field theory the perturbation coefficients are computed by summing Feynman graphs. A statistical procedure in a simple lambda phi 4 model for summing the set of all graphs as the number of vertices → infinity is presented. Finally, the connection between the large-order behavior of perturbation theory in quantum electrodynamics and the value of α, the charge on the electron, is discussed. 7 figures

  7. Performance analysis and optimization of radiating fins with a step change in thickness and variable thermal conductivity by homotopy perturbation method

    Arslanturk, Cihat

    2011-02-01

    Although tapered fins transfer more rate of heat per unit volume, they are not found in every practical application because of the difficulty in manufacturing and fabrications. Therefore, there is a scope to modify the geometry of a constant thickness fin in view of the less difficulty in manufacturing and fabrication as well as betterment of heat transfer rate per unit volume of the fin material. For the better utilization of fin material, it is proposed a modified geometry of new fin with a step change in thickness (SF) in the literature. In the present paper, the homotopy perturbation method has been used to evaluate the temperature distribution within the straight radiating fins with a step change in thickness and variable thermal conductivity. The temperature profile has an abrupt change in the temperature gradient where the step change in thickness occurs and thermal conductivity parameter describing the variation of thermal conductivity has an important role on the temperature profile and the heat transfer rate. The optimum geometry which maximizes the heat transfer rate for a given fin volume has been found. The derived condition of optimality gives an open choice to the designer.

  8. Perturbation of longitudinal relaxation rate in rotating frame (PLRF) analysis for quantification of chemical exchange saturation transfer signal in a transient state.

    Wang, Yi; Zhang, Yaoyu; Zhao, Xuna; Wu, Bing; Gao, Jia-Hong

    2017-11-01

    To develop a novel analytical method for quantification of chemical exchange saturation transfer (CEST) in the transient state. The proposed method aims to reduce the effects of non-chemical-exchange (non-CE) parameters on the CEST signal, emphasizing the effect of chemical exchange. The difference in the longitudinal relaxation rate in the rotating frame ( ΔR1ρ) was calculated based on perturbation of the Z-value by R1ρ, and a saturation-pulse-amplitude-compensated exchange-dependent relaxation rate (SPACER) was determined with a high-exchange-rate approximation. In both phantom and human subject experiments, MTRasym (representative of the traditional CEST index), ΔR1ρ, and SPACER were measured, evaluated, and compared by altering the non-CE parameters in a transient-state continuous-wave CEST sequence. In line with the theoretical expectation, our experimental data demonstrate that the effects of the non-CE parameters can be more effectively reduced using the proposed indices (  ΔR1ρ and SPACER) than using the traditional CEST index ( MTRasym). The proposed method allows for the chemical exchange weight to be better emphasized in the transient-state CEST signal, which is beneficial, in practice, for quantifying the CEST signal. Magn Reson Med 78:1711-1723, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  9. Does cortisol influence core executive functions? A meta-analysis of acute cortisol administration effects on working memory, inhibition, and set-shifting.

    Shields, Grant S; Bonner, Joseph C; Moons, Wesley G

    2015-08-01

    The hormone cortisol is often believed to play a pivotal role in the effects of stress on human cognition. This meta-analysis is an attempt to determine the effects of acute cortisol administration on core executive functions. Drawing on both rodent and stress literatures, we hypothesized that acute cortisol administration would impair working memory and set-shifting but enhance inhibition. Additionally, because cortisol is thought to exert different nongenomic (rapid) and genomic (slow) effects, we further hypothesized that the effects of cortisol would differ as a function of the delay between cortisol administration and cognitive testing. Although the overall analyses were nonsignificant, after separating the rapid, nongenomic effects of cortisol from the slower, genomic effects of cortisol, the rapid effects of cortisol enhanced response inhibition, g+ = 0.113, p=.016, but impaired working memory, g+ = -0.315, p=.008, although these effects reversed over time. Contrary to our hypotheses, there was no effect of cortisol administration on set-shifting. Thus, although we did not find support for the idea that increases in cortisol influence set-shifting, we found that acute increases in cortisol exert differential effects on working memory and inhibition over time. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. Spectral fitting for signal assignment and structural analysis of uniformly {sup 13}C-labeled solid proteins by simulated annealing based on chemical shifts and spin dynamics

    Matsuki, Yoh; Akutsu, Hideo; Fujiwara, Toshimichi [Osaka University, Institute for Protein Research (Japan)], E-mail: tfjwr@protein.osaka-u.ac.jp

    2007-08-15

    We describe an approach for the signal assignment and structural analysis with a suite of two-dimensional {sup 13}C-{sup 13}C magic-angle-spinning solid-state NMR spectra of uniformly {sup 13}C-labeled peptides and proteins. We directly fit the calculated spectra to experimental ones by simulated annealing in restrained molecular dynamics program CNS as a function of atomic coordinates. The spectra are calculated from the conformation dependent chemical shift obtained with SHIFTX and the cross-peak intensities computed for recoupled dipolar interactions. This method was applied to a membrane-bound 14-residue peptide, mastoparan-X. The obtained C', C{sup {alpha}} and C{sup {beta}} chemical shifts agreed with those reported previously at the precisions of 0.2, 0.7 and 0.4 ppm, respectively. This spectral fitting program also provides backbone dihedral angles with a precision of about 50 deg. from the spectra even with resonance overlaps. The restraints on the angles were improved by applying protein database program TALOS to the obtained chemical shifts. The peptide structure provided by these restraints was consistent with the reported structure at the backbone RMSD of about 1 A.

  11. ANALYSIS ON THE TRANSLATION OF WORDPLAYS IN “THE GOD OF SMALL THINGS” BY ARUNDHATI ROY (Studies on the Wordplay Shifts and the Translation Quality

    Nur Saptaningsih

    2017-04-01

    Full Text Available Wordplay commonly appears in literary works to enrich the works themselves with certain effect and nuance, either to make a joke or to conceal anything taboo. However, problems frequently occur in translation of wordplay and this becomes an obstacle for a translator to find proper equivalent. Moreover, the translation of wordplay is closely related to different language systems (source and target languages. Novel of ―The God of Small Things‖ by Arundhati Roy is rich in the use of wordplays, but there are a number of shifts found in the translated version of the wordplays. This paper deals with descriptivequalitative research aiming at investigating the shifts of wordplays in the novel of ―The God of Small Things‖ by Arundhati Roy and in the translated version. This study also highlights the contribution of the shifts on the translation quality, in terms of accuracy and acceptability. This product-oriented study applies embedded-case method. The first data for this research are documents, consisting of source text and the translated text. The other data are obtained from informants (raters and respondents, consisting of information dealing with accuracy and acceptability. The data are collected using document analyses, questionnaire, and interview. Purposive sampling and content analysis are applied.

  12. Analysis of user equilibrium for staggered shifts in a single-entry traffic corridor with no late arrivals

    Li, Chuan-Yao; Huang, Hai-Jun; Tang, Tie-Qiao

    2017-05-01

    In this paper, we investigate the effects of staggered shifts on the user equilibrium (UE) state in a single-entry traffic corridor with no late arrivals from the analytical and numerical perspective. The LWR (Lighthill-Whitham-Richards) model and the Greenshields' velocity-density function are used to describe the dynamic properties of traffic flow. Propositions for the properties of flow patterns in UE, and the quasi-analytic solutions for three possible situations in UE are deduced. Numerical tests are carried out to testify the analytical results, where the three-dimensional evolution diagram of traffic flow illustrates that shock and rarefaction wave exist in UE and the space-time diagram indicates that UE solutions satisfy the propagation properties of traffic flow. In addition, the cost curves show that the UE solutions satisfy the UE trip-timing condition.

  13. Structural analysis of flavonoids in solution through DFT 1H NMR chemical shift calculations: Epigallocatechin, Kaempferol and Quercetin

    De Souza, Leonardo A.; Tavares, Wagner M. G.; Lopes, Ana Paula M.; Soeiro, Malucia M.; De Almeida, Wagner B.

    2017-05-01

    In this work, we showed that comparison between experimental and theoretical 1H NMR chemical shift patterns, calculated using Density Functional Theory (DFT), can be used for the prediction of molecular structure of flavonoids in solution, what is experimentally accessible for gas phase (electron diffraction methods) and solid samples (X-ray diffraction). The best match between B3LYP/6-31G(d,p)-PCM 1H NMR calculations for B ring rotated structures and experimental spectra can provide information on the conformation adopted by polyphenols in solution (usually DMSO-d6, acetone-d6 as solvents), which may differ from solid state and gas phase observed structures, and also DFT optimized geometry in the vacuum.

  14. Perturbations of the Friedmann universe

    Novello, M.; Salim, J.M.; Heintzmann, H.

    1982-01-01

    Correcting and extending previous work by Hawking (1966) and Olson (1976) the complete set of perturbation equations of a Friedmann Universe in the quasi-Maxwellian form is derived and analized. The formalism is then applied to scalar, vector and tensor perturbations of a phenomenological fluid, which is modelled such as to comprise shear and heat flux. Depending on the equation of state of the background it is found that there exist unstable (growing) modes of purely rotational character. It is further found that (to linear order at least) any vortex perturbation is equivalent to a certain heat flux vector. The equation for the gravitational waves are derived in a completely equivalent method as in case of the propagation, in a curved space-time, of electromagnetic waves in a plasma endowed with some definite constitutive relations. (Author) [pt

  15. Analytic continuation in perturbative QCD

    Caprini, Irinel

    2002-01-01

    We discuss some attempts to improve standard perturbative expansion in QCD by using the analytic continuation in the momentum and the Borel complex planes. We first analyse the momentum-plane analyticity properties of the Borel-summed Green functions in perturbative QCD and the connection between the Landau singularities and the infrared renormalons. By using the analytic continuation in the Borel complex plane, we propose a new perturbative series replacing the standard expansion in powers of the normalized coupling constant a. The new expansion functions have branch point and essential singularities at the origin of the complex a-plane and divergent Taylor expansions in powers of a. On the other hand the modified expansion of the QCD correlators is convergent under rather conservative conditions. (author)

  16. Energy dependence phase shift analysis of PI4He elastic scattering and the possibility of the (PI4He) excited states existence

    Nichitiu, F.; Falomkin, I.V.; Sapozhnikov, M.G.; Shcherbakov, Yu.A.; Piragino, G.

    1981-06-01

    In the 24 MeV-260 MeV kinetic energy interval, the energy dependent phase shift analysis of π 4 He elastic scattering is done. The eneray dependence is given by the rational fraction approximants of the partial S matrix. The search for the stable S matrix zero-pole pairs in the k and √s complex plane give some proofs for the existence of the (π 4 He) excited states in the S, P and probably D partial waves. (authors)

  17. Perturbative coherence in field theory

    Aldrovandi, R.; Kraenkel, R.A.

    1987-01-01

    A general condition for coherent quantization by perturbative methods is given, because the basic field equations of a fild theory are not always derivable from a Lagrangian. It's seen that non-lagrangian models way have well defined vertices, provided they satisfy what they call the 'coherence condition', which is less stringent than the condition for the existence of a Lagrangian. They note that Lagrangian theories are perturbatively coherent, in the sense that they have well defined vertices, and that they satisfy automatically that condition. (G.D.F.) [pt

  18. Experimental assessment of the speed of light perturbation in free-fall absolute gravimeters

    Baumann, H; Blas, D.; Sibiryakov, S.; Eichenberger, A.; Klingelé, E.E.

    2015-01-01

    Precision absolute gravity measurements are growing in importance, especially in the context of the new definition of the kilogram. For the case of free-fall absolute gravimeters with a Michelson-type interferometer tracking the position of a free falling body, one of the effects that needs to be taken into account is the speed of light perturbation due to the finite speed of propagation of light. This effect has been extensively discussed in the past, and there is at present a disagreement between different studies. In this work, we present the analysis of new data and confirm the result expected from the theoretical analysis applied nowadays in free-fall gravimeters. We also review the standard derivations of this effect (by using phase shift or Doppler effect arguments) and show their equivalence.

  19. Theoretical analysis of a biogas-fed PEMFC system with different hydrogen purifications: Conventional and membrane-based water gas shift processes

    Authayanun, Suthida; Aunsup, Pounyaporn; Patcharavorachot, Yaneeporn; Arpornwichanop, Amornchai

    2014-01-01

    Highlights: • Thermodynamic analysis of the biogas-fed PEMFC system is performed. • Conventional and membrane-based WGS processes for H 2 purification are studied. • A flowsheet model of the PEMFC system is developed. • Effect of key parameters on yields of H 2 and carbon in the biogas reformer is shown. • Performance of PEMFC systems with different H 2 purification processes is analyzed. - Abstract: This study presents a thermodynamic analysis of biogas reforming and proton electrolyte membrane fuel cell (PEMFC) integrated process with different hydrogen purifications: conventional and membrane-based water gas shift processes. The aim is to determine the optimal reforming process for hydrogen production from biogas in the PEMFC system. The formation of carbon is concerned in the hydrogen production. The simulation results show that increases in the steam-to-methane ratio and reformer temperature can improve the hydrogen yield and reduce the carbon formation. From the performance analysis, it is found that when the PEMFC is operated at high temperature and fuel utilization, the overall system efficiency enhances. The performance of the PEMFC system with the installation of a water gas shift membrane unit in the hydrogen purification step is slightly increased, compared with a conventional process

  20. Analysis of South Atlantic Anomaly perturbations on Sentinel-3A Ultra Stable Oscillator. Impact on DORIS phase measurement and DORIS station positioning

    Jalabert, Eva; Mercier, Flavien

    2018-07-01

    DORIS measurements rely on the precise knowledge of the embedded oscillator which is called the Ultra Stable Oscillator (DORIS USO). The important radiations in the South Atlantic Anomaly (SAA) perturb the USO behavior by causing rapid frequency variations when the satellite is flying through the SAA. These variations are not taken into account in standard DORIS processing, since the USO is modelled as a third degree polynomial over 7-10 days. Therefore, there are systematic measurements errors when the satellite passes through SAA. In standard GNSS processing, the clock is directly estimated at each epoch. On Sentinel-3A, the GPS receiver and the DORIS receiver use the same USO. It is thus possible to estimate the behavior of the USO using GPS measurements. This estimated USO behavior can be used in the DORIS processing, instead of the third degree polynomial, hence allowing an estimation of the orbit sensitivity to these USO anomalies. This study shows two main results. First, the SAA effect on the DORIS USO is observed well using GPS measurements. Second, the USO behavior observed with GPS can be used to mitigate the SAA effect. Indeed, when used in Sentinel-3A processing, the resulting DORIS orbit shows improved phase measurements and station positioning for stations inside the SAA (Arequipa and Cachoeira). The phase measurements residuals are improved by up to 10 cm, and station vertical positioning (i.e. on the estimated Up component in the North-East-Up station frame) is improved by up to a few centimeters. However, the orbit itself is not sensitive to the correction because only two stations (out of almost 60) are SAA-sensitive on Sentinel-3A.

  1. Determination of metal balance shift induced in small fresh water fish by X-ray irradiation using PIXE analysis

    Yukawa, M.; Aoki, K.; Iso, H.; Kodama, K.; Imaseki, H.; Ishikawa, Y.

    2005-01-01

    In the environmental pollution studies, it is very important to detect not only pollutants but also changes induced in organisms in the environment with various environmental stresses such as heavy metal toxicity radiation and agricultural chemicals. In the latter, monitoring is carried out using biological indicators to find out the changes, which have wide spectra from visible like deformity of the body to invisible such as changes in some enzyme activities. Changes of the balance of essential elements could occur in organisms to deal with the stresses. If we detect an elemental balance shift, we may see the environmental pollution in its early stages. Moreover, in the actual environment, combined effects, additive or reductive with coexistent elements or other stresses, is an important subject for investigation. Therefore, measurement of many elements in the biological indicator's simultaneously and determination of the distribution in the organisms are useful in clarifying the action of pollutants at sublethal levels. A small fresh water fish, Medaka can be used as one of the biological-indicators for determination of water quality. In the National Institute of Radiological Sciences (NIRS), an inbred strain of Medaka Orizias laptipes was established and has been maintained for the research purposes. Since the genetic background of inbred animals is almost uniform, the individual deviation among animals is very small. This characteristic is very useful to investigate the physiological effects of environmental stresses. We have continued to investigate the balance shift of essential elements induced in the bodies of Medaka by several stresses. In this paper, elemental content in various organs of the X-ray irradiated fish determined by PIXE method are reported in comparison with that of the control fish to observe the effect of the X-rays. Body size of Medaka is about 3 cm long, and the internal organs are very small (about l mm on average). PIXE is the most

  2. Methods and applications of analytical perturbation theory

    Kirchgraber, U.; Stiefel, E.

    1978-01-01

    This monograph on perturbation theory is based on various courses and lectures held by the authors at the ETH, Zurich and at the University of Texas, Austin. Its principal intention is to inform application-minded mathematicians, physicists and engineers about recent developments in this field. The reader is not assumed to have mathematical knowledge beyond what is presented in standard courses on analysis and linear algebra. Chapter I treats the transformations of systems of differential equations and the integration of perturbed systems in a formal way. These tools are applied in Chapter II to celestial mechanics and to the theory of tops and gyroscopic motion. Chapter III is devoted to the discussion of Hamiltonian systems of differential equations and exposes the algebraic aspects of perturbation theory showing also the necessary modifications of the theory in case of singularities. The last chapter gives the mathematical justification for the methods developed in the previous chapters and investigates important questions such as error estimations for the solutions and asymptotic stability. Each chapter ends with useful comments and an extensive reference to the original literature. (HJ) [de

  3. On relevant boundary perturbations of unitary minimal models

    Recknagel, A.; Roggenkamp, D.; Schomerus, V.

    2000-01-01

    We consider unitary Virasoro minimal models on the disk with Cardy boundary conditions and discuss deformations by certain relevant boundary operators, analogous to tachyon condensation in string theory. Concentrating on the least relevant boundary field, we can perform a perturbative analysis of renormalization group fixed points. We find that the systems always flow towards stable fixed points which admit no further (non-trivial) relevant perturbations. The new conformal boundary conditions are in general given by superpositions of 'pure' Cardy boundary conditions

  4. Perturbations from cosmic strings in cold dark matter

    Albrecht, Andreas; Stebbins, Albert

    1991-01-01

    A systematic linear analysis of the perturbations induced by cosmic strings in cold dark matter is presented. The power spectrum is calculated and it is found that the strings produce a great deal of power on small scales. It is shown that the perturbations on interesting scales are the result of many uncorrelated string motions, which indicates a much more Gaussian distribution than was previously supposed.

  5. Stark shift and g-factor tuning in nanowires with Rashba effect

    Alhaddad, Iman; Habanjar, Khulud [Department of Physics, Faculty of Science, Beirut Arab University, P.O. Box 11, 5020 Riad El Solh, 11072809 - Beirut (Lebanon); Sakr, M.R., E-mail: msakr@alexu.edu.eg [Department of Physics, Faculty of Science, Beirut Arab University, P.O. Box 11, 5020 Riad El Solh, 11072809 - Beirut (Lebanon); Department of Physics, Faculty of Science, Alexandria University, Moharram Bek, Alexandria 21511 (Egypt)

    2015-10-15

    We report on the Stark shift of the energy subbands and the possibility of tuning the g-factor of electrons in nanowires subjected to external magnetic field. The electric field is applied along the direction of quantum confinement. Our analysis is based on numerical and perturbation calculations in the weak Rashba regime. For in-plane magnetic fields, the Stark shift is rigid and depends on the square of the electric field. Such rigid shift results in a field independent g-factor. Perpendicular magnetic fields induce a similar Stark shift accompanied by a lateral displacement of the energy spectra that is linear in the electric field. In this case, the g-factor shows square dependence on weak electric fields that varies with the subband index. However, in strong electric fields, the g-factor becomes subband independent and varies linearly with the field. - Highlights: • Energy spectra of electrons in nanowires are calculated in the weak Rashba regime. • For in-plane magnetic field, the Stark shift is rigid and the g-factor cannot be tuned. • Perpendicular magnetic fields add lateral displacement to the Stark shift. • The g-factor can be tuned by external electric field in this case. • The tuning of the g-factor is linear and unique for all subbands at high fields.

  6. Stark shift and g-factor tuning in nanowires with Rashba effect

    Alhaddad, Iman; Habanjar, Khulud; Sakr, M.R.

    2015-01-01

    We report on the Stark shift of the energy subbands and the possibility of tuning the g-factor of electrons in nanowires subjected to external magnetic field. The electric field is applied along the direction of quantum confinement. Our analysis is based on numerical and perturbation calculations in the weak Rashba regime. For in-plane magnetic fields, the Stark shift is rigid and depends on the square of the electric field. Such rigid shift results in a field independent g-factor. Perpendicular magnetic fields induce a similar Stark shift accompanied by a lateral displacement of the energy spectra that is linear in the electric field. In this case, the g-factor shows square dependence on weak electric fields that varies with the subband index. However, in strong electric fields, the g-factor becomes subband independent and varies linearly with the field. - Highlights: • Energy spectra of electrons in nanowires are calculated in the weak Rashba regime. • For in-plane magnetic field, the Stark shift is rigid and the g-factor cannot be tuned. • Perpendicular magnetic fields add lateral displacement to the Stark shift. • The g-factor can be tuned by external electric field in this case. • The tuning of the g-factor is linear and unique for all subbands at high fields

  7. Cosmological perturbation theory and quantum gravity

    Brunetti, Romeo [Dipartimento di Matematica, Università di Trento,Via Sommarive 14, 38123 Povo TN (Italy); Fredenhagen, Klaus [II Institute für Theoretische Physik, Universität Hamburg,Luruper Chaussee 149, 22761 Hamburg (Germany); Hack, Thomas-Paul [Institute für Theoretische Physik, Universität Leipzig,Brüderstr. 16, 04103 Leipzig (Germany); Pinamonti, Nicola [Dipartimento di Matematica, Università di Genova,Via Dodecaneso 35, 16146 Genova (Italy); INFN, Sezione di Genova,Via Dodecaneso 33, 16146 Genova (Italy); Rejzner, Katarzyna [Department of Mathematics, University of York,Heslington, York YO10 5DD (United Kingdom)

    2016-08-04

    It is shown how cosmological perturbation theory arises from a fully quantized perturbative theory of quantum gravity. Central for the derivation is a non-perturbative concept of gauge-invariant local observables by means of which perturbative invariant expressions of arbitrary order are generated. In particular, in the linearised theory, first order gauge-invariant observables familiar from cosmological perturbation theory are recovered. Explicit expressions of second order quantities are presented as well.

  8. Chaotic inflation with metric and matter perturbations

    Feldman, H.A.; Brandenberger, R.H.

    1989-01-01

    A perturbative scheme to analyze the evolution of both metric and scalar field perturbations in an expanding universe is developed. The scheme is applied to study chaotic inflation with initial metric and scalar field perturbations present. It is shown that initial gravitational perturbations with wavelength smaller than the Hubble radius rapidly decay. The metric simultaneously picks up small perturbations determined by the matter inhomogeneities. Both are frozen in once the wavelength exceeds the Hubble radius. (orig.)

  9. Design considerations in projection phase-shift moiré topography based on theoretical analysis of fringe formation.

    Buytaert, Jan A N; Dirckx, Joris J J

    2007-07-01

    Moiré topography is a well-established optical technique to measure the shape of three-dimensional surfaces, based on the geometric interference between an optical grid and its image deformed by an object surface. The technique produces fringes that represent contours of equal height, and from the recordings of several phase-shifted topograms surface height coordinates can be calculated. To perform these calculations, it is assumed that object height variation is small in comparison with the measurement setup dimensions, and this approximation leads to systematic errors in measurement accuracy. We present the mathematical description of the fringe formation process in projection moiré topography, and on the basis of these equations we establish the relation between setup geometry and upper limits of the systematic measurement errors. We derive the equations that determine design specifications needed to reduce the effects of approximations to be below the measurement resolution of the setup. It is shown that setup geometry should be adapted to the gray-scale measurement resolution of the imaging system. We show that, using an iterative correction from one fringe order to the next, measurement accuracy can be maintained over the entire object depth.

  10. Lateral femoral notch depth is not associated with increased rotatory instability in ACL-injured knees: a quantitative pivot shift analysis.

    Kanakamedala, Ajay C; Burnham, Jeremy M; Pfeiffer, Thomas R; Herbst, Elmar; Kowalczuk, Marcin; Popchak, Adam; Irrgang, James; Fu, Freddie H; Musahl, Volker

    2018-05-01

    A deep lateral femoral notch (LFN) on lateral radiographs is indicative of ACL injury. Prior studies have suggested that a deep LFN may also be a sign of persistent rotatory instability and a concomitant lateral meniscus tear. Therefore, the purpose of this study was to evaluate the relationship between LFN depth and both quantitative measures of rotatory knee instability and the incidence of lateral meniscus tears. It was hypothesized that greater LFN depth would be correlated with increased rotatory instability, quantified by lateral compartment translation and tibial acceleration during a quantitative pivot shift test, and incidence of lateral meniscus tears. ACL-injured patients enrolled in a prospective ACL registry from 2014 to 2016 were analyzed. To limit confounders, patients were only included if they had primary ACL tears, no concurrent ligamentous or bony injuries requiring operative treatment, and no previous knee injuries or surgeries to either knee. Eighty-four patients were included in the final analysis. A standardized quantitative pivot shift test was performed pre-operatively under anesthesia in both knees, and rotatory instability, specifically lateral compartment translation and tibial acceleration, was quantified using tablet image analysis software and accelerometer sensors. Standard lateral radiographs and sagittal magnetic resonance images (MRI) of the injured knee were evaluated for LFN depth. There were no significant correlations between LFN depth on either imaging modality and ipsilateral lateral compartment translation or tibial acceleration during a quantitative pivot shift test or side-to-side differences in these measurements. Patients with lateral meniscus tears were found to have significantly greater LFN depths than those without on conventional radiograph and MRI (1.0 vs. 0.6 mm, p quantitative measures of rotatory instability. Concomitant lateral meniscus injury was associated with significantly greater LFN depth. Based on

  11. Steady State Shift Damage Localization

    Sekjær, Claus; Bull, Thomas; Markvart, Morten Kusk

    2017-01-01

    The steady state shift damage localization (S3DL) method localizes structural deterioration, manifested as either a mass or stiffness perturbation, by interrogating the damage-induced change in the steady state vibration response with damage patterns cast from a theoretical model. Damage is, thus...... the required accuracy when examining complex structures, an extensive amount of degrees of freedom (DOF) must often be utilized. Since the interrogation matrix for each damage pattern depends on the size of the system matrices constituting the FE-model, the computational time quickly becomes of first......-order importance. The present paper investigates two sub-structuring approaches, in which the idea is to employ Craig-Bampton super-elements to reduce the amount of interrogation distributions while still providing an acceptable localization resolution. The first approach operates on a strict super-element level...

  12. Basics of QCD perturbation theory

    Soper, D.E.

    1997-01-01

    This is an introduction to the use of QCD perturbation theory, emphasizing generic features of the theory that enable one to separate short-time and long-time effects. The author also covers some important classes of applications: electron-positron annihilation to hadrons, deeply inelastic scattering, and hard processes in hadron-hadron collisions. 31 refs., 38 figs

  13. Current issues in perturbative QCD

    Hinchliffe, I.

    1994-12-01

    This review talk discusses some issues of active research in perturbative QCD. The following topics are discussed: (1) current value of αs; (2) heavy quark production in hadron collisions; (3) production of Ψ and Υ in p anti p collisions; (4) prompt photon production; (5) small-x and related phenomena; and (6) particle multiplicity in heavy quark jets

  14. New results in perturbative QCD

    Ellis, R.K.

    1986-01-01

    Three topics in perturbative QCD important for Super-collider physics are reviewed. The topics are: 1. (2 → 2) jet phenomena calculated in O(αs 3 ). 2. New techniques for the calculation of tree graphs. 3. Color coherence in jet phenomena. 31 references, 6 figures

  15. Perturbation theory from stochastic quantization

    Hueffel, H.

    1984-01-01

    By using a diagrammatical method it is shown that in scalar theories the stochastic quantization method of Parisi and Wu gives the usual perturbation series in Feynman diagrams. It is further explained how to apply the diagrammatical method to gauge theories, discussing the origin of ghost effects. (Author)

  16. Seven topics in perturbative QCD

    Buras, A.J.

    1980-09-01

    The following topics of perturbative QCD are discussed: (1) deep inelastic scattering; (2) higher order corrections to e + e - annihilation, to photon structure functions and to quarkonia decays; (3) higher order corrections to fragmentation functions and to various semi-inclusive processes; (4) higher twist contributions; (5) exclusive processes; (6) transverse momentum effects; (7) jet and photon physics

  17. Reggeon interactions in perturbative QCD

    Kirschner, R.

    1994-08-01

    We study the pairwise interaction of reggeized gluons and quarks in the Regge limit of perturbative QCD. The interactions are represented as integral kernels in the transverse momentum space and as operators in the impact parameter space. We observe conformal symmetry and holomorphic factorization in all cases. (orig.)

  18. Basics of QCD perturbation theory

    Soper, D.E. [Univ. of Oregon, Eugene, OR (United States). Inst. of Theoretical Science

    1997-06-01

    This is an introduction to the use of QCD perturbation theory, emphasizing generic features of the theory that enable one to separate short-time and long-time effects. The author also covers some important classes of applications: electron-positron annihilation to hadrons, deeply inelastic scattering, and hard processes in hadron-hadron collisions. 31 refs., 38 figs.

  19. Status of chiral perturbation theory

    Ecker, G.

    1996-10-01

    A survey is made of semileptonic and nonleptonic kaon decays in the framework of chiral perturbation theory. The emphasis is on what has been done rather than how it was done. The theoretical predictions are compared with available experimental results. (author)

  20. Principles of chiral perturbation theory

    Leutwyler, H.

    1995-01-01

    An elementary discussion of the main concepts used in chiral perturbation theory is given in textbooks and a more detailed picture of the applications may be obtained from the reviews. Concerning the foundations of the method, the literature is comparatively scarce. So, I will concentrate on the basic concepts and explain why the method works. (author)

  1. Superfield perturbation theory and renormalization

    Delbourgo, R.

    1975-01-01

    The perturbation theory graphs and divergences in super-symmetric Lagrangian models are studied by using superfield techniques. In super PHI 3 -theory very little effort is needed to arrive at the single infinite (wave function) renormalization counterterm, while in PHI 4 -theory the method indicates the counter-Lagrangians needed at the one-loop level and possibly beyond

  2. Chiral symmetry in perturbative QCD

    Trueman, T.L.

    1979-04-01

    The chiral symmetry of quantum chromodynamics with massless quarks is unbroken in perturbation theory. Dimensional regularization is used. The ratio of the vector and axial vector renormalization constante is shown to be independent of the renormalization mass. The general results are explicitly verified to fourth order in g, the QCD coupling constant

  3. Perturbative QCD and exclusive processes

    Bennett, J.; Hawes, F.; Zhao, M.; Zyla, P.

    1991-01-01

    The authors discuss perturbation theory as applied to particle physics calculations. In particle physics one is generally interested in the scattering amplitude for a system going from some initial state to a final state. The intermediate state or states are unknown. To get the scattering amplitude it is necessary to sum the contributions from processes which pass through all possible intermediate states. Intermediate states involve the exchange of intermediate vector bosons between the particles, and with this interaction is associated a coupling constant α. Each additional boson exchange involves an additional contribution of α to the coupling. If α is less than 1, one can see that the relative contribution of higher order processes is less and less important as α falls. In QCD the gluons serve as the intermediate vector bosons exchanged by quarks and gluons, and the interaction constant is not really a constant, but depends upon the distance between the particles. At short distances the coupling is small, and one can assume perturbative expansions may converge rapidly. Exclusive scattering processes, as opposed to inclusive, are those in which all of the final state products are detected. The authors then discuss the application of perturbative QCD to the deuteron. The issues of chiral conservation and color transparancy are also discussed, in the scheme of large Q 2 interations, where perturbative QCD should be applicable

  4. Perturbative treatment of nuclear rotations

    Civitarese, O.

    1980-01-01

    In this work, it is described the case corresponding to perturbative quantum treatment of a fermion system in free rotation and the divergences which resulted from the 'break' in symmetry, associated by the adoption of a deformed basis as a non pertubed solution. (A.C.A.S.) [pt

  5. Blue and red shifted temperature dependence of implicit phonon shifts in graphene

    Mann, Sarita; Jindal, V. K.

    2017-07-01

    We have calculated the implicit shift for various modes of frequency in a pure graphene sheet. Thermal expansion and Grüneisen parameter which are required for implicit shift calculation have already been studied and reported. For this calculation, phonon frequencies are obtained using force constants derived from dynamical matrix calculated using VASP code where the density functional perturbation theory (DFPT) is used in interface with phonopy software. The implicit phonon shift shows an unusual behavior as compared to the bulk materials. The frequency shift is large negative (red shift) for ZA and ZO modes and the value of negative shift increases with increase in temperature. On the other hand, blue shift arises for all other longitudinal and transverse modes with a similar trend of increase with increase in temperature. The q dependence of phonon shifts has also been studied. Such simultaneous red and blue shifts in transverse or out plane modes and surface modes, respectively leads to speculation of surface softening in out of plane direction in preference to surface melting.

  6. Combined chemical shift changes and amino acid specific chemical shift mapping of protein-protein interactions

    Schumann, Frank H.; Riepl, Hubert [University of Regensburg, Institute of Biophysics and Physical Biochemistry (Germany); Maurer, Till [Boehringer Ingelheim Pharma GmbH and Co. KG, Analytical Sciences Department (Germany); Gronwald, Wolfram [University of Regensburg, Institute of Biophysics and Physical Biochemistry (Germany); Neidig, Klaus-Peter [Bruker BioSpin GmbH, Software Department (Germany); Kalbitzer, Hans Robert [University of Regensburg, Institute of Biophysics and Physical Biochemistry (Germany)], E-mail: hans-robert.kalbitzer@biologie.uni-regensburg.de

    2007-12-15

    Protein-protein interactions are often studied by chemical shift mapping using solution NMR spectroscopy. When heteronuclear data are available the interaction interface is usually predicted by combining the chemical shift changes of different nuclei to a single quantity, the combined chemical shift perturbation {delta}{delta}{sub comb}. In this paper different procedures (published and non-published) to calculate {delta}{delta}{sub comb} are examined that include a variety of different functional forms and weighting factors for each nucleus. The predictive power of all shift mapping methods depends on the magnitude of the overlap of the chemical shift distributions of interacting and non-interacting residues and the cut-off criterion used. In general, the quality of the prediction on the basis of chemical shift changes alone is rather unsatisfactory but the combination of chemical shift changes on the basis of the Hamming or the Euclidian distance can improve the result. The corrected standard deviation to zero of the combined chemical shift changes can provide a reasonable cut-off criterion. As we show combined chemical shifts can also be applied for a more reliable quantitative evaluation of titration data.

  7. Development of advanced BWR fuel bundle with spectral shift rod (3) -transient analysis of ABWR core with SSR

    Ikegawa, T.; Chaki, M.; Ohga, Y.; Abe, M.

    2010-01-01

    The spectral shift rod (SSR) is a new type of water rod, utilized instead of the conventional water rod, in which a water level develops during core operation. The water level can be changed according to the fuel channel flow rate. In this study, ABWR plant performance with SSR fuel bundles under transient conditions has been evaluated using the TRACG code. The TRACG code, which can treat three-dimensional hydrodynamic calculations in a reactor pressure vessel, is well suited for evaluating the reactor transient performance with the SSR fuel bundles because it can calculate the water levels in the SSR at each channel grouping and therefore evaluate the core reactivity according to the water level changes in the SSR. 'Generator load rejection with total turbine bypass failure' and 'Recirculation flow control failure with increasing flow' were selected as cases which may increase the reactivity with the increasing water level in the SSR. It was found that the absolute value of the void reactivity coefficient in the SSR core was larger than that in the conventional water rod core because the core averaged void fraction in the SSR core, which has the vapor region above the water level in the SSR, was larger than that in the conventional water rod core. Therefore, AMCPR for the SSR core was a little larger than that for the conventional water rod core; however, the difference was smaller than 0.02 because the inlet of the SSR ascending path was designed to be small enough to prevent the rapid water level increase in the SSR. (authors)

  8. Item response theory and factor analysis as a mean to characterize occurrence of response shift in a longitudinal quality of life study in breast cancer patients

    2014-01-01

    Background The occurrence of response shift (RS) in longitudinal health-related quality of life (HRQoL) studies, reflecting patient adaptation to disease, has already been demonstrated. Several methods have been developed to detect the three different types of response shift (RS), i.e. recalibration RS, 2) reprioritization RS, and 3) reconceptualization RS. We investigated two complementary methods that characterize the occurrence of RS: factor analysis, comprising Principal Component Analysis (PCA) and Multiple Correspondence Analysis (MCA), and a method of Item Response Theory (IRT). Methods Breast cancer patients (n = 381) completed the EORTC QLQ-C30 and EORTC QLQ-BR23 questionnaires at baseline, immediately following surgery, and three and six months after surgery, according to the “then-test/post-test” design. Recalibration was explored using MCA and a model of IRT, called the Linear Logistic Model with Relaxed Assumptions (LLRA) using the then-test method. Principal Component Analysis (PCA) was used to explore reconceptualization and reprioritization. Results MCA highlighted the main profiles of recalibration: patients with high HRQoL level report a slightly worse HRQoL level retrospectively and vice versa. The LLRA model indicated a downward or upward recalibration for each dimension. At six months, the recalibration effect was statistically significant for 11/22 dimensions of the QLQ-C30 and BR23 according to the LLRA model (p ≤ 0.001). Regarding the QLQ-C30, PCA indicated a reprioritization of symptom scales and reconceptualization via an increased correlation between functional scales. Conclusions Our findings demonstrate the usefulness of these analyses in characterizing the occurrence of RS. MCA and IRT model had convergent results with then-test method to characterize recalibration component of RS. PCA is an indirect method in investigating the reprioritization and reconceptualization components of RS. PMID:24606836

  9. Proton range shift analysis on brain pseudo-CT generated from T1 and T2 MR.

    Pileggi, Giampaolo; Speier, Christoph; Sharp, Gregory C; Izquierdo Garcia, David; Catana, Ciprian; Pursley, Jennifer; Amato, Francesco; Seco, Joao; Spadea, Maria Francesca

    2018-05-29

    In radiotherapy, MR imaging is only used because it has significantly better soft tissue contrast than CT, but it lacks electron density information needed for dose calculation. This work assesses the feasibility of using pseudo-CT (pCT) generated from T1w/T2w MR for proton treatment planning, where proton range comparisons are performed between standard CT and pCT. MR and CT data from 14 glioblastoma patients were used in this study. The pCT was generated by using conversion libraries obtained from tissue segmentation and anatomical regioning of the T1w/T2w MR. For each patient, a plan consisting of three 18 Gy beams was designed on the pCT, for a total of 42 analyzed beams. The plan was then transferred onto the CT that represented the ground truth. Range shift (RS) between pCT and CT was computed at R 80 over 10 slices. The acceptance threshold for RS was according to clinical guidelines of two institutions. A γ-index test was also performed on the total dose for each patient. Mean absolute error and bias for the pCT were 124 ± 10 and -16 ± 26 Hounsfield Units (HU), respectively. The median and interquartile range of RS was 0.5 and 1.4 mm, with highest absolute value being 4.4 mm. Of the 42 beams, 40 showed RS less than the clinical range margin. The two beams with larger RS were both in the cranio-caudal direction and had segmentation errors due to the partial volume effect, leading to misassignment of the HU. This study showed the feasibility of using T1w and T2w MRI to generate a pCT for proton therapy treatment, thus avoiding the use of a planning CT and allowing better target definition and possibilities for online adaptive therapies. Further improvements of the methodology are still required to improve the conversion from MRI intensities to HUs.

  10. Molecular and Silica-Supported Molybdenum Alkyne Metathesis Catalysts: Influence of Electronics and Dynamics on Activity Revealed by Kinetics, Solid-State NMR, and Chemical Shift Analysis.

    Estes, Deven P; Gordon, Christopher P; Fedorov, Alexey; Liao, Wei-Chih; Ehrhorn, Henrike; Bittner, Celine; Zier, Manuel Luca; Bockfeld, Dirk; Chan, Ka Wing; Eisenstein, Odile; Raynaud, Christophe; Tamm, Matthias; Copéret, Christophe

    2017-12-06

    Molybdenum-based molecular alkylidyne complexes of the type [MesC≡Mo{OC(CH 3 ) 3-x (CF 3 ) x } 3 ] (MoF 0 , x = 0; MoF 3 , x = 1; MoF 6 , x = 2; MoF 9 , x = 3; Mes = 2,4,6-trimethylphenyl) and their silica-supported analogues are prepared and characterized at the molecular level, in particular by solid-state NMR, and their alkyne metathesis catalytic activity is evaluated. The 13 C NMR chemical shift of the alkylidyne carbon increases with increasing number of fluorine atoms on the alkoxide ligands for both molecular and supported catalysts but with more shielded values for the supported complexes. The activity of these catalysts increases in the order MoF 0 molecular and supported species. Detailed solid-state NMR analysis of molecular and silica-supported metal alkylidyne catalysts coupled with DFT/ZORA calculations rationalize the NMR spectroscopic signatures and discernible activity trends at the frontier orbital level: (1) increasing the number of fluorine atoms lowers the energy of the π*(M≡C) orbital, explaining the more deshielded chemical shift values; it also leads to an increased electrophilicity and higher reactivity for catalysts up to MoF 6 , prior to a sharp decrease in reactivity for MoF 9 due to the formation of stable metallacyclobutadiene intermediates; (2) the silica-supported catalysts are less active than their molecular analogues because they are less electrophilic and dynamic, as revealed by their 13 C NMR chemical shift tensors.

  11. Time for a real shift to relations: appraisal of Social Network Analysis applications in the UK construction industry

    Ximing Ruan

    2013-03-01

    Full Text Available The Social Network Analysis (SNA has been adopted in the UK construction management research and generated meaningful insights in analysing project management organisations from network perspectives. As an effective tool, social network analysis has been used to analyse information and knowledge flow between construction project teams which is considered as foundation for collaborative working and subsequently improving overall performance. Social network analysis is based on an assumption of the importance of relationships among interacting units. The social network perspective encompasses theories, models and applications that are expressed in terms of relational concepts or processes. Many believe, moreover, that the success or failure of organisations often depends on the patterning of their internal structure. This paper reviewed existing literatures on SNA applications in construction industry from three leading construction management journals.  From the review, the research proposed some advance in the application of SNA in the construction industry. 

  12. Time for a real shift to relations: appraisal of Social Network Analysis applications in the UK construction industry

    Ximing Ruan

    2013-03-01

    Full Text Available The Social Network Analysis (SNA has been adopted in the UK construction management research and generated meaningful insights in analysing project management organisations from network perspectives. As an effective tool, social network analysis has been used to analyse information and knowledge flow between construction project teams which is considered as foundation for collaborative working and subsequently improving overall performance. Social network analysis is based on an assumption of the importance of relationships among interacting units. The social network perspective encompasses theories, models and applications that are expressed in terms of relational concepts or processes. Many believe, moreover, that the success or failure of organisations often depends on the patterning of their internal structure. This paper reviewed existing literatures on SNA applications in construction industry from three leading construction management journals.  From the review, the research proposed some advance in the application of SNA in the construction industry.

  13. A Comparative Analysis of New Governance Instruments in the Transnational Educational Space: A Shift to Knowledge-Based Instruments?

    Ioannidou, Alexandra

    2007-01-01

    In recent years, the ongoing development towards a knowledge-based society--associated with globalization, an aging population, new technologies and organizational changes--has led to a more intensive analysis of education and learning throughout life with regard to quantitative, qualitative and financial aspects. In this framework, education…

  14. Shifting Identity Positions in the Development of Language Education for Immigrants: An Analysis of Discourses Associated with "Swedish for Immigrants"

    Rosen, Jenny Karin; Bagga-Gupta, Sangeeta

    2013-01-01

    The study presented in this paper focuses upon conceptualisations of language and identity in the institutionalised arena that emerged in the post-Second World War period with the specific intention of teaching Swedish to adult immigrants in the nation-state of Sweden. Our analysis focuses upon the development of the educational programme…

  15. Systematic Review and Meta-analysis of the Effects of Caffeine in Fatigued Shift Workers: Implications for Emergency Medical Services Personnel

    2018-01-11

    Background: Emergency Medical Services (EMS) workers may experience fatigue as a consequence of shift work. We reviewed the literature to determine the impact of caffeine as a countermeasure to fatigue in EMS personnel and related shift workers. Meth...

  16. Micropatch Antenna Phase Shifting

    Thursby, Michael

    2000-01-01

    .... We have been looking at the ability of embedded element to adjust the phase shift seen by the element with the goal of being able to remove the phase shifting devices from the antenna and replace...

  17. Micropatch Antenna Phase Shifting

    Thursby, Michael

    1999-01-01

    .... We have been looking at the ability of embedded element to adjust the phase shift seen by the element wit the goal of being able to remove the phase shifting devices from the antenna and replace...

  18. Perturbations in electromagnetic dark energy

    Jiménez, Jose Beltrán; Maroto, Antonio L.; Koivisto, Tomi S.; Mota, David F.

    2009-01-01

    It has been recently proposed that the presence of a temporal electromagnetic field on cosmological scales could explain the phase of accelerated expansion that the universe is currently undergoing. The field contributes as a cosmological constant and therefore, the homogeneous cosmology produced by such a model is exactly the same as that of ΛCDM. However, unlike a cosmological constant term, electromagnetic fields can acquire perturbations which in principle could affect CMB anisotropies and structure formation. In this work, we study the evolution of inhomogeneous scalar perturbations in this model. We show that provided the initial electromagnetic fluctuations generated during inflation are small, the model is perfectly compatible with both CMB and large scale structure observations at the same level of accuracy as ΛCDM

  19. Perturbative instabilities in Horava gravity

    Bogdanos, Charalampos; Saridakis, Emmanuel N

    2010-01-01

    We investigate the scalar and tensor perturbations in Horava gravity, with and without detailed balance, around a flat background. Once both types of perturbations are taken into account, it is revealed that the theory is plagued by ghost-like scalar instabilities in the range of parameters which would render it power-counting renormalizable, that cannot be overcome by simple tricks such as analytic continuation. Implementing a consistent flow between the UV and IR limits seems thus more challenging than initially presumed, regardless of whether the theory approaches general relativity at low energies or not. Even in the phenomenologically viable parameter space, the tensor sector leads to additional potential problems, such as fine-tunings and super-luminal propagation.

  20. A thermalization energy analysis of the threshold voltage shift in amorphous indium gallium zinc oxide thin film transistors under simultaneous negative gate bias and illumination

    Flewitt, A. J., E-mail: ajf@eng.cam.ac.uk [Electrical Engineering Division, Cambridge University, J J Thomson Avenue, Cambridge CB3 0FA (United Kingdom); Powell, M. J. [252, Valley Drive, Kendal LA9 7SL (United Kingdom)

    2014-04-07

    It has been previously observed that thin film transistors (TFTs) utilizing an amorphous indium gallium zinc oxide (a-IGZO) semiconducting channel suffer from a threshold voltage shift when subjected to a negative gate bias and light illumination simultaneously. In this work, a thermalization energy analysis has been applied to previously published data on negative bias under illumination stress (NBIS) in a-IGZO TFTs. A barrier to defect conversion of 0.65–0.75 eV is extracted, which is consistent with reported energies of oxygen vacancy migration. The attempt-to-escape frequency is extracted to be 10{sup 6}−10{sup 7} s{sup −1}, which suggests a weak localization of carriers in band tail states over a 20–40 nm distance. Models for the NBIS mechanism based on charge trapping are reviewed and a defect pool model is proposed in which two distinct distributions of defect states exist in the a-IGZO band gap: these are associated with states that are formed as neutrally charged and 2+ charged oxygen vacancies at the time of film formation. In this model, threshold voltage shift is not due to a defect creation process, but to a change in the energy distribution of states in the band gap upon defect migration as this allows a state formed as a neutrally charged vacancy to be converted into one formed as a 2+ charged vacancy and vice versa. Carrier localization close to the defect migration site is necessary for the conversion process to take place, and such defect migration sites are associated with conduction and valence band tail states. Under negative gate bias stressing, the conduction band tail is depleted of carriers, but the bias is insufficient to accumulate holes in the valence band tail states, and so no threshold voltage shift results. It is only under illumination that the quasi Fermi level for holes is sufficiently lowered to allow occupation of valence band tail states. The resulting charge localization then allows a negative threshold voltage