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Sample records for serum replacement sr

  1. The replacement of serum by hormones in cell culture media.

    Science.gov (United States)

    Sato, G; Hayashi, I

    1976-12-01

    The replacement of serum by hormones in cell culture media. (Reemplazo del suero por hormonas en el medio de cultivo de células). Arch. Biol. Med. Exper. 10: 120-121, 1976. The serum used in cell culture media can be replaced by a mixture of hormones and some accesory blood factors. The pituitary cell line GH3 can be grown in a medium in which serum is replaced by triiodothyronine, transferrin, parathormone, tyrotrophin releasing hormone and somatomedins. Hela and BHK cell strains can also be grown in serum free medium supplemented with hormones. Each cell type appears to have different hormonal requirements yet it may found that some hormones are required for most cell types.

  2. A low percentage of autologous serum can replace bovine serum to engineer human nasal cartilage

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    F Wolf

    2008-02-01

    Full Text Available For the generation of cell-based therapeutic products, it would be preferable to avoid the use of animal-derived components. Our study thus aimed at investigating the possibility to replace foetal bovine serum (FBS with autologous serum (AS for the engineering of cartilage grafts using expanded human nasal chondrocytes (HNC. HNC isolated from 7 donors were expanded in medium containing 10% FBS or AS at different concentrations (2%, 5% and 10% and cultured in pellets using serum-free medium or in Hyaff®-11 meshes using medium containing FBS or AS. Tissue forming capacity was assessed histologically (Safranin O, immunohistochemically (type II collagen and biochemically (glycosaminoglycans -GAG- and DNA. Differences among experimental groups were assessed by Mann Whitney tests. HNC expanded under the different serum conditions proliferated at comparable rates and generated cartilaginous pellets with similar histological appearance and amounts of GAG. Tissues generated by HNC from different donors cultured in Hyaff®-11 had variable quality, but the accumulated GAG amounts were comparable among the different serum conditions. Staining intensity for collagen type II was consistent with GAG deposition. Among the different serum conditions tested, the use of 2% AS resulted in the lowest variability in the GAG contents of generated tissues. In conclusion, a low percentage of AS can replace FBS both during the expansion and differentiation of HNC and reduce the variability in the quality of the resulting engineered cartilage tissues.

  3. Generation of hematopoietic stem cells from human embryonic stem cells using a defined, stepwise, serum-free, and serum replacement-free monolayer culture method.

    Science.gov (United States)

    Kim, So-Jung; Jung, Ji-Won; Ha, Hye-Yeong; Koo, Soo Kyung; Kim, Eung-Gook; Kim, Jung-Hyun

    2017-03-01

    Embryonic stem cells (ESCs) can be expanded infinitely in vitro and have the potential to differentiate into hematopoietic stem cells (HSCs); thus, they are considered a useful source of cells for HSC production. Although several technical in vitro methods for engineering HSCs from pluripotent stem cells have been developed, clinical application of HSCs engineered from pluripotent stem cells is restricted because of the possibility of xenogeneic contamination resulting from the use of murine materials. Human ESCs (CHA-hES15) were cultured on growth factor-reduced Matrigel-coated dishes in the mTeSR1 serum-free medium. When the cells were 70% confluent, we initiated HSC differentiation by three methods involving (1) knockout serum replacement (KSR), cytokines, TGFb1, EPO, and FLT3L; (2) KSR, cytokines, and bFGF; or (3) cytokines and bFGF. Among the three differentiation methods, the minimal number of cytokines without KSR resulted in the greatest production of HSCs. The optimized method resulted in a higher proportion of CD34 + CD43 + hematopoietic progenitor cells (HPCs) and CD34 + CD45 + HPCs compared to the other methods. In addition, the HSCs showed the potential to differentiate into multiple lineages of hematopoietic cells in vitro . In this study, we optimized a two-step, serum-free, animal protein-free, KSR-free, feeder-free, chemically defined monolayer culture method for generation of HSCs and hematopoietic stem and progenitor cells (HSPCs) from human ESCs.

  4. Platelet-rich plasma can replace fetal bovine serum in human meniscus cell cultures

    NARCIS (Netherlands)

    Gonzales, V.K.; Mulder, E.L.W. de; Boer, T. den; Hannink, G.; Tienen, T.G. van; Heerde, W.L. van; Buma, P.

    2013-01-01

    Concerns over fetal bovine serum (FBS) limit the clinical application of cultured tissue-engineered constructs. Therefore, we investigated if platelet-rich plasma (PRP) can fully replace FBS for meniscus tissue engineering purposes. Human PRP and platelet-poor plasma (PPP) were isolated from three

  5. The effect of hormone replacement therapy on serum homocysteine levels in perimenopausal women : a randomized controlled trial

    NARCIS (Netherlands)

    Hak, AE; Bak, AAA; Lindemans, J; Planellas, J; Bennink, HJTC; Hofman, A; Grobbee, DE; Witteman, JCM

    2001-01-01

    Serum homocysteine levels may be lowered by hormone replacement therapy, but randomized controlled trial data are scarce. We performed a single center randomized placebo-controlled trial to assess the 6 months effect of hormone replacement therapy compared with placebo on fasting serum homocysteine

  6. Serum beta-2 microglobulin levels for predicting acute kidney injury complicating aortic valve replacement.

    Science.gov (United States)

    Zaleska-Kociecka, Marta; Skrobisz, Anna; Wojtkowska, Izabela; Grabowski, Maciej; Dabrowski, Maciej; Kusmierski, Krzysztof; Piotrowska, Katarzyna; Imiela, Jacek; Stepinska, Janina

    2017-10-01

    Acute kidney injury complicating both transcatheter and surgical aortic valve replacement is associated with high rates of morbidity and mortality. The aim of this study was to investigate the role of serum beta 2 (β2) microglobulin, cystatin C and neutrophil gelatinase-associated lipocalin levels in detecting periprocedural acute kidney injury. Eighty consecutive patients who were 70 years of age or older and who were having surgical (n = 40) or transcatheter (n = 40) aortic valve replacement were recruited in a prospective study. The biomarkers were tested before the procedure, 6 times afterwards, at discharge and at a 6-month follow-up visit. The baseline β2-microglobulin level was the strongest predictor of acute kidney injury as a complication of transcatheter aortic valve replacement [odds ratio (OR) 5.277, P = 0.009]. Its level 24 h after the procedure reached the largest area under the curve (AUC) of 0.880 (P regression analysis, the levels of β2-microglobulin and cystatin C 24 h after the procedure were significantly associated with acute kidney injury after transcatheter valve replacement (OR 38.15, P = 0.044; OR 1782, P = 0.019, respectively). In the surgical aortic valve replacement group, the highest AUCs belonged to β2-microglobulin and cystatin C at 24 h (AUC = 0.808, P = 0.003 and AUC = 0.854, P = 0.001, respectively). Their higher values were also associated with acute kidney injury (OR 17.2, P = 0.018; OR 965.6, P = 0.02, respectively). A persistent increase in the postoperative levels of β2-microglobulin following acute kidney injury was associated with the progression of chronic kidney disease for 6 months after both transcatheter (OR 6.56, P = 0.030) and surgical (OR 7.67, P = 0.03) aortic valve replacements. Serum β2-microglobulin had the potential to predict acute kidney injury complicating transcatheter valve replacement and to diagnose it as early as 24 h after both the

  7. Knockout Serum Replacement Promotes Cell Survival by Preventing BIM from Inducing Mitochondrial Cytochrome C Release.

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    Yuki Ishii

    Full Text Available Knockout serum replacement (KOSR is a nutrient supplement commonly used to replace serum for culturing stem cells. We show here that KOSR has pro-survival activity in chronic myelogenous leukemia (CML cells transformed by the BCR-ABL oncogene. Inhibitors of BCR-ABL tyrosine kinase kill CML cells by stimulating pro-apoptotic BIM and inhibiting anti-apoptotic BCL2, BCLxL and MCL1. We found that KOSR protects CML cells from killing by BCR-ABL inhibitors--imatinib, dasatinib and nilotinib. The protective effect of KOSR is reversible and not due to the selective outgrowth of drug-resistant clones. In KOSR-protected CML cells, imatinib still inhibited the BCR-ABL tyrosine kinase, reduced the phosphorylation of STAT, ERK and AKT, down-regulated BCL2, BCLxL, MCL1 and up-regulated BIM. However, these pro-apoptotic alterations failed to cause cytochrome c release from the mitochondria. With mitochondria isolated from KOSR-cultured CML cells, we showed that addition of recombinant BIM protein also failed to cause cytochrome c release. Besides the kinase inhibitors, KOSR could protect cells from menadione, an inducer of oxidative stress, but it did not protect cells from DNA damaging agents. Switching from serum to KOSR caused a transient increase in reactive oxygen species and AKT phosphorylation in CML cells that were protected by KOSR but not in those that were not protected by this nutrient supplement. Treatment of KOSR-cultured cells with the PH-domain inhibitor MK2206 blocked AKT phosphorylation, abrogated the formation of BIM-resistant mitochondria and stimulated cell death. These results show that KOSR has cell-context dependent pro-survival activity that is linked to AKT activation and the inhibition of BIM-induced cytochrome c release from the mitochondria.

  8. Human platelet lysate: Replacing fetal bovine serum as a gold standard for human cell propagation?

    Science.gov (United States)

    Burnouf, Thierry; Strunk, Dirk; Koh, Mickey B C; Schallmoser, Katharina

    2016-01-01

    The essential physiological role of platelets in wound healing and tissue repair builds the rationale for the use of human platelet derivatives in regenerative medicine. Abundant growth factors and cytokines stored in platelet granules can be naturally released by thrombin activation and clotting or artificially by freeze/thaw-mediated platelet lysis, sonication or chemical treatment. Human platelet lysate prepared by the various release strategies has been established as a suitable alternative to fetal bovine serum as culture medium supplement, enabling efficient propagation of human cells under animal serum-free conditions for a multiplicity of applications in advanced somatic cell therapy and tissue engineering. The rapidly increasing number of studies using platelet derived products for inducing human cell proliferation and differentiation has also uncovered a considerable variability of human platelet lysate preparations which limits comparability of results. The main variations discussed herein encompass aspects of donor selection, preparation of the starting material, the possibility for pooling in plasma or additive solution, the implementation of pathogen inactivation and consideration of ABO blood groups, all of which can influence applicability. This review outlines the current knowledge about human platelet lysate as a powerful additive for human cell propagation and highlights its role as a prevailing supplement for human cell culture capable to replace animal serum in a growing spectrum of applications. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. Replacement of serum with ocular fluid for cryopreservation of immature testes.

    Science.gov (United States)

    Pothana, Lavanya; Devi, Lalitha; Venna, Naresh Kumar; Pentakota, Niharika; Varma, Vivek Phani; Jose, Jedy; Goel, Sandeep

    2016-12-01

    Cryopreservation of immature testis is a feasible approach for germplasm preservation of male animals. Combinations of dimethyl sulfoxide (DMSO) and foetal bovine serum (FBS) are used for testis cryopreservation. However, an alternative to FBS is needed, because FBS is expensive. Buffalo ocular fluid (BuOF), a slaughter house by-product, could be an economical option. The objective of the present study was to assess whether BuOF can replace FBS for cryopreservation of immature mouse (Mus musculus), rat (Rattus norvegicus), and buffalo (Bubalus bubalis) testes. Results showed that rodent and buffalo testes frozen in DMSO (10% for rodents and 20% for buffalo) with 20% FBS or BuOF had similar numbers of viable and DNA-damaged cells (P > 0.05). The expression of cell proliferation- (PCNA) and apoptosis-specific proteins (Annexin V and BAX/BCL2 ratio) were also comparable in mouse and buffalo testes frozen in DMSO with FBS or BuOF (P > 0.05). Interestingly, rat testis frozen in DMSO with BuOF had lower expression of Annexin V protein than testis frozen in DMSO with FBS (P  0.05). These findings provide evidence that BuOF has potential to replace FBS for cryopreservation of immature rodent and buffalo testis. Further investigation is needed to explore whether BuOF can replace FBS for testis cryopreservation of other species. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Circadian variation in serum cortisol during hydrocortisone replacement is not attributable to changes in cortisol-binding globulin concentrations.

    Science.gov (United States)

    Chung, T T; Gunganah, K; Monson, J P; Drake, W M

    2016-04-01

    Patients taking hydrocortisone (HC) replacement for primary or secondary adrenal failure require individual adjustment of their dose. In addition to modifying the administered doses of HC for each patient, physicians are increasingly interested in variations in the bioavailability of glucocorticoid replacement. One potential determinant of the bioavailability of replaced HC is a variation in serum cortisol-binding globulin (CBG) concentration, which may, in turn, affect interpretation of cortisol profiles and individual dose selection for patients on hydrocortisone replacement therapy. To investigate the hypothesis that there is a circadian variation in CBG levels. A total of 34 male patients divided into 3 groups (10 patients with non-somatotroph structural pituitary disease on HC replacement, 11 patients with treated acromegaly on HC replacement and 13 patients with treated acromegaly not on HC replacement) and 10 healthy volunteers were included. Cortisol and CBG levels were measured at 6 time points (0800, 1100, 1300, 1500, 1700 and 1900). No significant circadian variation in CBG concentration was found in any of the 4 groups. Circadian variation in serum cortisol during hydrocortisone replacement is not attributable to changes in cortisol-binding globulin concentration. Changes in serum cortisol levels may thus be explained by other factors including 11 β-hydroxysteroid dehydrogenase type 1 activity or circadian changes in the binding properties of CBG. © 2015 John Wiley & Sons Ltd.

  11. Replacement

    Directory of Open Access Journals (Sweden)

    S. Radhakrishnan

    2014-03-01

    Full Text Available The fishmeal replaced with Spirulina platensis, Chlorella vulgaris and Azolla pinnata and the formulated diet fed to Macrobrachium rosenbergii postlarvae to assess the enhancement ability of non-enzymatic antioxidants (vitamin C and E, enzymatic antioxidants (superoxide dismutase (SOD and catalase (CAT and lipid peroxidation (LPx were analysed. In the present study, the S. platensis, C. vulgaris and A. pinnata inclusion diet fed groups had significant (P < 0.05 improvement in the levels of vitamins C and E in the hepatopancreas and muscle tissue. Among all the diets, the replacement materials in 50% incorporated feed fed groups showed better performance when compared with the control group in non-enzymatic antioxidant activity. The 50% fishmeal replacement (best performance diet fed groups taken for enzymatic antioxidant study, in SOD, CAT and LPx showed no significant increases when compared with the control group. Hence, the present results revealed that the formulated feed enhanced the vitamins C and E, the result of decreased level of enzymatic antioxidants (SOD, CAT and LPx revealed that these feeds are non-toxic and do not produce any stress to postlarvae. These ingredients can be used as an alternative protein source for sustainable Macrobrachium culture.

  12. Platelet lysate as a serum replacement for skin cell culture on biomimetic PCL nanofibers.

    Science.gov (United States)

    Sovkova, Vera; Vocetkova, Karolina; Rampichova, Michala; Mickova, Andrea; Buzgo, Matej; Lukasova, Vera; Dankova, Jana; Filova, Eva; Necas, Alois; Amler, Evzen

    2018-06-01

    Platelets are a popular source of native growth factors for tissue engineering applications. The aim of the study was to verify the use of platelet lysate as a fetal bovine serum (FBS) replacement for skin cell culture. The cytokine content of the platelet lysate was characterized using the Bio-Plex system. The cells (fibroblasts, melanocytes, and keratinocytes) were cultured on PCL nanofibrous scaffolds to mimic their natural microenvironment. The cytokine content of the platelet lysate was determined, and to the cells, a medium containing platelet lysate or platelet lysate in combination with FBS was added. The results showed that 7% (v/v) platelet lysate was sufficient to supplement 10% (v/v) FBS in the culture of fibroblasts and keratinocytes. The combination of platelet lysate and FBS had a rather inhibitory effect on fibroblasts, in contrary to keratinocytes, where the effect was synergic. Platelet lysate did not sufficiently promote proliferation in melanocytes; however, the combination of FBS and platelet lysate yielded a better outcome and resulted in bipolar morphology of the cultured melanocytes. The data indicated that platelet lysate improved cell proliferation and metabolic activity and may be used as an additive to the cell culture media.

  13. Testosterone replacement elevates the serum uric acid levels in patients with female to male gender identity disorder.

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    Kurahashi, Hiroaki; Watanabe, Masami; Sugimoto, Morito; Ariyoshi, Yuichi; Mahmood, Sabina; Araki, Motoo; Ishii, Kazushi; Nasu, Yasutomo; Nagai, Atsushi; Kumon, Hiromi

    2013-01-01

    Gender identity disorder (GID) results from a disagreement between a person's biological sex and the gender to which he or she identifies. With respect to the treatment of female to male GID, testosterone replacement therapy (TRT) is available. The uric acid (UA) level can be influenced by testosterone; however, the early effects and dose-dependency of TRT on the serum UA concentration have not been evaluated in this population. We herein conducted a dose-response analysis of TRT in 160 patients with female to male GID. The TRT consisted of three treatment groups who received intramuscular injections of testosterone enanthate: 125 mg every two weeks, 250 mg every three weeks and 250 mg every two weeks. Consequently, serum UA elevation was observed after three months of TRT and there was a tendency toward testosterone dose-dependency. The onset of hyperuricemia was more prevalent in the group who received the higher dose. We also demonstrated a positive correlation between increased levels of serum UA and serum creatinine. Since the level of serum creatinine represents an individual's muscle volume and the muscle is a major source of purine, which induces UA upregulation, the serum UA elevation observed during TRT is at least partially attributed to an increase in muscle mass. This is the first study showing an association between serum UA elevation and a TRT-induced increase in muscle mass. The current study provides important information regarding TRT for the follow-up and management of the serum UA levels in GID patients.

  14. Ocular Fluid As a Replacement for Serum in Cell Cryopreservation Media.

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    Vivek Phani Varma

    Full Text Available Cryostorage is of immense interest in biomedical research, especially for stem cell-based therapies and fertility preservation. Several protocols have been developed for efficient cryopreservation of cells and tissues, and a combination of dimethyl sulfoxide (DMSO and fetal bovine serum (FBS is commonly used. However, there is a need for an alternative to FBS because of ethical reasons, high cost, and risk of contamination with blood-borne diseases. The objective of the present study was to examine the possibility of using buffalo (Bubalus bubalis ocular fluid (BuOF to replace FBS in cryomedia. Frozen-thawed cells, which were cryopreserved in a cryomedia with BuOF, were assessed for viability, early and late apoptosis, and proliferation. Three cell lines (CHO, HEK, and C18-4, mouse embryonic stem (mES cells, and primary cells, such as mouse embryonic fibroblast (MEF cells, human peripheral blood mononuclear cells (hPBMCs, and mouse bone marrow cells (mBMCs, were cryopreserved in cryomedia containing 10% DMSO (D10 with 20% FBS (D10S20 or D10 with 20% BuOF (D10O20. For all three cell lines and mES cells cryopreserved in either D10S20 or D10O20, thawed cells showed no difference in cell viability or cell recovery. Western blot analysis of frozen-thawed-cultured cells revealed that the expression of Annexin V and proliferating cell nuclear antigen (PCNA proteins, and the ratio of BAX/BCL2 proteins were similar in all three cell lines, mES cells, and hPBMCs cryopreserved in D10S20 and D10O20. However, initial cell viability, cell recovery after culture, and PCNA expression were significantly lower in MEF cells, and the BAX/BCL2 protein ratio was elevated in mBMCs cryopreserved in D10O20. Biochemical and proteomic analysis of BuOF showed the presence of several components that may have roles in imparting the cryoprotective property of BuOF. These results encourage further research to develop an efficient serum-free cryomedia for several cell types

  15. Can serums be replaced by Mueller‑Hinton agar in germ tube test ...

    African Journals Online (AJOL)

    Background: The germ tube test (GTT) is inexpensive, easy, and well‑defined test that differentiates Candida albicans (excluding Candida dubliniensis and Candida africana) from other species. The aim of this study was to evaluate various serums (i.e., human, rabbit, horse, and fetal bovine serum) used in the GTT and ...

  16. Can serums be replaced by Mueller‑Hinton agar in germ tube test?

    African Journals Online (AJOL)

    2016-03-03

    Mar 3, 2016 ... various serums (i.e., human, rabbit, horse, and fetal bovine serum) used in the GTT and Mueller‑Hinton agar (MHA). Materials and Methods: Fifty species isolated from various clinical samples that were defined as C. albicans by both conventional and DNA sequence analysis methods were included in the ...

  17. Effects of Replacing Soybean Meal with Fermented Rapeseed Meal on Performance, Serum Biochemical Variables and Intestinal Morphology of Broilers

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    F. Z. Xu

    2012-12-01

    Full Text Available This trial was performed to study the effects of replacing soybean meal (SBM with fermented rapeseed meal (RSM on growth performance, serum biochemistry variable and intestinal morphology of broilers. A total of 640 d-old Arbor Acres broiler chicks were randomly allocated to 4 dietary treatments, 4 pens per treatment and 40 birds per pen for a 6-wk feeding trial. In the four treatment groups, fermented RSM replaced soybean meal at 0, 5, 10, and 15%, respectively. On 21 d and 42 d, two birds from each pen were randomly selected and slaughtered. Blood samples and sections of duodenum, jejunum, and ileum were collected for measurement of serum biochemical variables and intestinal morphology, respectively. Results showed that body weight gain (BWG and feed conversion (FC were significantly (p<0.01 poorer for birds fed the 15% fermented RSM diet than those fed with 0, 5 and 10% fermented RSM diets during all periods. Compared with 0 and 5% fermented RSM groups, IgG content in the serum of birds in 10 and 15% fermented RSM groups was improved (p<0.01 urea nitrogen content of serum was reduced (p<0.01 during both growing and finishing periods. However, IgM, phosphorus and calcium levels increased (p<0.05 only during the growing period. Increased (p<0.05 villus height was observed in the duodenum and jejunum of broilers fed the diet with 10% fermented RSM. In addition, villus height to crypt depth ratio in the jejunum was significantly higher (p<0.01 for birds fed the diet with 10% fermented RSM than for those fed diets with 0, 5 and 15% fermented RSM. The present results suggest that RSM fermented with Lactobacillus fermentum and Bacillus subtilis is a promising alternative protein source and that it could be safely used replace up to 10% SBM in broiler diets.

  18. Human bones obtained from routine joint replacement surgery as a tool for studies of plutonium, americium and {sup 90}Sr body-burden in general public

    Energy Technology Data Exchange (ETDEWEB)

    Mietelski, Jerzy W., E-mail: jerzy.mietelski@ifj.edu.pl [Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, 31-342 Cracow (Poland); Golec, Edward B. [Traumatology and Orthopaedic Clinic, 5th Military Clinical Hospital and Polyclinic, Independent Public Healthcare Facility, Wroclawska 1-3, 30-901 Cracow (Poland); Orthopaedic Rehabilitation Department, Chair of Clinical Rehabilitation, Faculty of Motor of the Bronislaw Czech' s Academy of Physical Education, Cracow (Poland); Department of Physical Therapy Basics, Faculty of Physical Therapy, Administration College, Bielsko-Biala (Poland); Tomankiewicz, Ewa [Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, 31-342 Cracow (Poland); Golec, Joanna [Orthopaedic Rehabilitation Department, Chair of Clinical Rehabilitation, Faculty of Motor of the Bronislaw Czech' s Academy of Physical Education, Cracow (Poland); Physical Therapy Department, Institute of Physical Therapy, Faculty of Heath Science, Jagiellonian University, Medical College, Cracow (Poland); Nowak, Sebastian [Traumatology and Orthopaedic Clinic, 5th Military Clinical Hospital and Polyclinic, Independent Public Healthcare Facility, Wroclawska 1-3, 30-901 Cracow (Poland); Orthopaedic Rehabilitation Department, Chair of Clinical Rehabilitation, Faculty of Motor of the Bronislaw Czech' s Academy of Physical Education, Cracow (Poland); Szczygiel, Elzbieta [Physical Therapy Department, Institute of Physical Therapy, Faculty of Heath Science, Jagiellonian University, Medical College, Cracow (Poland); Brudecki, Kamil [Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, 31-342 Cracow (Poland)

    2011-06-15

    The paper presents a new sampling method for studying in-body radioactive contamination by bone-seeking radionuclides such as {sup 90}Sr, {sup 239+240}Pu, {sup 238}Pu, {sup 241}Am and selected gamma-emitters, in human bones. The presented results were obtained for samples retrieved from routine surgeries, namely knee or hip joints replacements with implants, performed on individuals from Southern Poland. This allowed to collect representative sets of general public samples. The applied analytical radiochemical procedure for bone matrix is described in details. Due to low concentrations of {sup 238}Pu the ratio of Pu isotopes which might be used for Pu source identification is obtained only as upper limits other then global fallout (for example Chernobyl) origin of Pu. Calculated concentrations of radioisotopes are comparable to the existing data from post-mortem studies on human bones retrieved from autopsy or exhumations. Human bones removed during knee or hip joint surgery provide a simple and ethical way for obtaining samples for plutonium, americium and {sup 90}Sr in-body contamination studies in general public. - Highlights: > Surgery for joint replacement as novel sampling method for studying in-body radioactive contamination. > Proposed way of sampling is not causing ethic doubts. > It is a convenient way of collecting human bone samples from global population. > The applied analytical radiochemical procedure for bone matrix is described in details. > The opposite patient age correlations trends were found for 90Sr (negative) and Pu, Am (positive).

  19. Salivary Cortisol Can Replace Free Serum Cortisol Measurements in Patients With Septic Shock

    Science.gov (United States)

    Orlander, Philip R.

    2011-01-01

    Background: There is a renewed interest in adrenal function during severe sepsis. Most studies have used total serum cortisol levels; however, only free serum cortisol is biologically active. The aim of this study was to determine the validity of salivary cortisol levels as a surrogate for free serum cortisol levels during septic shock. Methods: Fifty-seven patients with septic shock were studied to determine the correlation between total serum cortisol and salivary cortisol to free serum cortisol levels. Thirty-eight patients were included in the salivary to free serum cortisol correlation. Salivary cortisol level was tested by enzyme immunoassay. Serum total cortisol, free cortisol, and cortisol-binding globulin (CBG) levels were determined by liquid chromatography-mass spectrometry, equilibrium analysis, and radioimmunoassay, respectively. Results: The mean ± SD age was 56.6 ± 18.5 years. Fifty-seven percent were women. APACHE (Acute Physiology and Chronic Health Evaluation) II score median was 26, Simplified Acute Physiology Score II median was 61, and Sequential Organ Failure Assessment median was 13. The correlation between salivary and free serum cortisol levels was 0.79 (95% CI, 0.63-0.89; P cortisol and total serum cortisol levels was 0.86 (95% CI, 0.78-0.92; P cortisol level was 2.27 ± 1.64 μg/dL. The mean ± SD salivary cortisol level was 2.60 ± 2.69 μg/dL. The mean ± SD total serum cortisol level was 21.56 ± 8.71 μg/dL. The mean ± SD CBG level was 23.54 ± 8.33 mg/dL. Conclusions: Salivary cortisol level can be used as a surrogate of free serum cortisol level in patients with septic shock with very good correlation. Salivary cortisol testing is noninvasive, easy to perform, and can be conducted daily. Trial registry: ClinicalTrials.gov; No.: NCT00523198; URL: www.clinicaltrials.gov PMID:21816912

  20. Study on changes of serum lipid profile after withdrawl of levo-thyroxine replacement therapy in patients with radical thyroidectomy for cancer

    International Nuclear Information System (INIS)

    Yang Shumin; Yu Lili; Dong Lin; Zhu Gaohong; Zhang Jijian

    2010-01-01

    Objective: To study the changes of serum lipid profile after withdrawl of levo-thyroxine replacement for 4 weeks in patient with radical thyroidectomy for cancer. Methods: Serum thyroid hormones (FT 3 , FT 4 , sTSH, with RIA) levels and lipid profile (Total cholesterol, triglycerides, LDL, HDL, apolipoprotein A-I, apolipoprotein B and Lp (a), with biochemistry) were determined in 46 patients with thyroid carcinoma after operation both during and after 4 weeks' withdrawl of levo-thyroxine replacement treatment. Results: Serum FT 3 , FT 4 levels decreased significantly and serum sTSH, TC, TG, LDL, apo-B, Lp (a) levels increased significantly after 4 weeks' withdrawl of levo-thyroxine replacement (vs during treatment, P 0.05). Conclusion: Hyperlipidaemia did develop in the hypothyroid patients after withdrawl of levo-thyroxine replacement but the degree of which did not not necessarily correlate with the increment of sTSH levels. (authors)

  1. A role for the high-density lipoprotein receptor SR-B1 in synovial inflammation via serum amyloid-A.

    LENUS (Irish Health Repository)

    Mullan, Ronan Hugh

    2012-02-01

    Acute phase apoprotein Serum Amyloid A (A-SAA), which is strongly expressed in rheumatoid arthritis synovial membrane (RA SM), induces angiogenesis, adhesion molecule expression, and matrix metalloproteinase production through the G-coupled receptor FPRL-1. Here we report alternative signaling through the high-density lipoprotein receptor scavenger receptor-class B type 1 (SR-B1). Quantitative expression\\/localization of SR-B1 in RA SM, RA fibroblast-like cells (FLCs), and microvascular endothelial cells (ECs) was assessed by Western blotting and immunohistology\\/fluorescence. A-SAA-mediated effects were examined using a specific antibody against SR-B1 or amphipathic alpha-Helical Peptides (the SR-B1 antagonists L-37pA and D-37pA), in RA FLCs and ECs. Adhesion molecule expression and cytokine production were quantified using flow cytometry and ELISA. SR-B1 was strongly expressed in the RA SM lining layer and endothelial\\/perivascular regions compared with osteoarthritis SM or normal control synovium. Differential SR-B1 expression in RA FLC lines (n = 5) and ECs correlated closely with A-SAA, but not tumor necrosis factor alpha-induced intercellular adhesion molecule-1 upregulation. A-SAA-induced interleukin-6 and -8 production was inhibited in the presence of anti-SR-B1 in human microvascular endothelial cells and RA FLCs. Moreover, D-37pA and L-37pA inhibited A-SAA-induced vascular cell adhesion molecule-1 and intercellular adhesion molecule expression from ECs in a dose-dependent manner. As SR-B1 is expressed in RA synovial tissue and mediates A-SAA-induced pro-inflammatory pathways, a better understanding of A-SAA-mediated inflammatory pathways may lead to novel treatment strategies for RA.

  2. Deconvolution analysis of 24-h serum cortisol profiles informs the amount and distribution of hydrocortisone replacement therapy.

    Science.gov (United States)

    Peters, Catherine J; Hill, Nathan; Dattani, Mehul T; Charmandari, Evangelia; Matthews, David R; Hindmarsh, Peter C

    2013-03-01

    Hydrocortisone therapy is based on a dosing regimen derived from estimates of cortisol secretion, but little is known of how the dose should be distributed throughout the 24 h. We have used deconvolution analysis of 24-h serum cortisol profiles to determine 24-h cortisol secretion and distribution to inform hydrocortisone dosing schedules in young children and older adults. Twenty four hour serum cortisol profiles from 80 adults (41 men, aged 60-74 years) and 29 children (24 boys, aged 5-9 years) were subject to deconvolution analysis using an 80-min half-life to ascertain total cortisol secretion and distribution throughout the 24-h period. Mean daily cortisol secretion was similar between adults (6.3 mg/m(2) body surface area/day, range 5.1-9.3) and children (8.0 mg/m(2) body surface area/day, range 5.3-12.0). Peak serum cortisol concentration was higher in children compared with adults, whereas nadir serum cortisol concentrations were similar. Timing of the peak serum cortisol concentration was similar (07.05-07.25), whereas that of the nadir concentration occurred later in adults (midnight) compared with children (22.48) (P = 0.003). Children had the highest percentage of cortisol secretion between 06.00 and 12.00 (38.4%), whereas in adults this took place between midnight and 06.00 (45.2%). These observations suggest that the daily hydrocortisone replacement dose should be equivalent on average to 6.3 mg/m(2) body surface area/day in adults and 8.0 mg/m(2) body surface area/day in children. Differences in distribution of the total daily dose between older adults and young children need to be taken into account when using a three or four times per day dosing regimen. © 2012 Blackwell Publishing Ltd.

  3. Effects of the Replacement of Soybean Meal with Pea as Dietary Protein Source on the Serum Protein Fractions of Broilers

    Directory of Open Access Journals (Sweden)

    NT Bingol

    Full Text Available ABSTRACT The aim of this study was to determine the effects of the replacement of different levels of protein derived from soybean meal with that from peas in broiler diets on serum protein fractions. A corn-soybean meal basal diet was formulated as the control diet (Control=C (NRC, 1994, and then pea was added to the control diet to replace 20% (P20 or 40% (P40 of the crude protein of the control diet. The diets were randomly fed to 12 pens per treatment, each housing five birds, for 42 days. Blood samples were collected from 36 birds (3 birds x 4 pens x3 treatments and the serum protein fractions were separated. Gamma-globulin percentage was higher in group P20 compared with C and P40 groups. Total protein, beta-globulin, and gamma-globulin concentrations were significantly higher in group P20 compared with those of both control and P40 group (p<0.05.

  4. Platelet lysate: a replacement for fetal bovine serum in animal cell culture?

    OpenAIRE

    Johansson, Liselott; Klinth, Jeanna; Holmqvist, Olov; Ohlson, Sten

    2003-01-01

    A new cell culture supplement, platelet lysate, was evaluated with reference to fetal bovine serum (FBS), an established industrial medium for animal cell culture. Chemical and bacteriological profiles were conducted including the presence of platelet-derived growth factor (PDGF). PDGF was detected in the platelet lysate but it was not present in FBS. The platelet lysate medium demonstrated lack of microorganisms, mycoplasma and endotoxins. The platelet lysate was investigated in culture stud...

  5. Seasonal variations in TSH serum levels in athyreotic patients under L-thyroxine replacement monotherapy.

    Science.gov (United States)

    Gullo, Damiano; Latina, Adele; Frasca, Francesco; Squatrito, Sebastiano; Belfiore, Antonino; Vigneri, Riccardo

    2017-08-01

    Whether serum TSH undergoes seasonal fluctuations in euthyroid and hypothyroid residents of temperate climates is controversial. Monthly TSH and thyroid hormone levels were cross-sectionally analysed in a large cohort of euthyroid subjects (n=11 806) and L-thyroxine (L-T4)-treated athyreotic patients (n=3 934). Moreover, in a small group (n=119) of athyreotic patients treated with an unchanged dosage of L-T4 monotherapy, hormones were measured both in the coldest and in the hottest seasons of the same year (longitudinal study). No seasonal hormone change was observed in the euthyroid subjects except for a small FT3 increase in winter (+2.9%, P<.001). In contrast, the L-T4-treated athyreotic patients had significantly higher serum TSH values in the cold season when the FT4 values were significantly lower. The differences were more notable in the longitudinal series (TSH, 0.80 vs. 0.20 mU/L and FT4, 16.3 vs. 17.8 pmol/L in December-March vs. June-September, respectively). In these patients also serum FT3 values significantly decreased in winter (in the longitudinal series, 3.80 in winter vs 4.07 pmol/L in summer). Regression analysis showed that in athyreotic subjects, a greater FT4 change is required to obtain a TSH change similar to that of euthyroid controls and that this effect is more pronounced in the summer. Athyreotic patients undergoing L-T4 monotherapy have abnormal seasonal variations in TSH. These changes are secondary to the FT4 and FT3 serum decreases in winter, which occur in spite of the constant treatment. The underlying mechanisms are unclear, but in some cases, these changes may be clinically relevant. © 2017 John Wiley & Sons Ltd.

  6. Platelet lysate as replacement for fetal bovine serum in mesenchymal stromal cell cultures.

    Science.gov (United States)

    Bieback, Karen

    2013-10-01

    Mesenchymal stromal cells (MSC) emerged as highly attractive in cell-based regenerative medicine. Initially thought to provide cells capable of differentiation towards mesenchymal cell types (osteoblasts, chondrocytes, adipocytes etc.), by and by potent immunoregulatory and pro-regenerative activities have been discovered, broadening the field of potential applications from bone and cartilage regeneration to wound healing and treatment of autoimmune diseases. Due to the limited frequency in most tissue sources, ex vivo expansion of MSC is required compliant with good manufacturing practice (GMP) guidelines to yield clinically relevant cell doses. Though, still most manufacturing protocols use fetal bovine serum (FBS) as cell culture supplement to isolate and to expand MSC. However, the high lot-to-lot variability as well as risk of contamination and immunization call for xenogenic-free culture conditions. In terms of standardization, chemically defined media appear as the ultimate achievement. Since these media need to maintain all key cellular and therapy-relevant features of MSC, the development of chemically defined media is still - albeit highly investigated - only in its beginning. The current alternatives to FBS rely on human blood-derived components: plasma, serum, umbilical cord blood serum, and platelet derivatives like platelet lysate. Focusing on quality aspects, the latter will be addressed within this review.

  7. Human Platelet Lysate as a Replacement for Fetal Bovine Serum in Limbal Stem Cell Therapy.

    Science.gov (United States)

    Suri, Kunal; Gong, Hwee K; Yuan, Ching; Kaufman, Stephen C

    2016-10-01

    To evaluate the use of human platelet lysate (HPL) as an alternative supplement for limbal explant culture. Culture media were prepared using either 10% pooled HPL (PHPL), single donor HPL, or fetal bovine serum (FBS). Limbal tissues, obtained from the Minnesota Lions Eye Bank, were cultured in each medium on plastic plates or on denuded amniotic membrane (AM). Immunofluorescence staining was performed for ABCG2, tumor protein p63α, and cytokeratin 3 (K3). Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) was used to evaluate the expression of ABCG2 and p63. Limbal explants grown in each medium were labeled with bromodeoxyuridine (BrdU) to assess the proliferative capacity in each medium. Concentration of growth factors including epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), and platelet derived growth factor (PDGF) in HPL and PHPL was compared to that in human serum (HS). Immunofluorescence staining on AM showed prominent expression of ABCG2, p63α but sparse expression of K3 in HPL and PHPL supplemented medium. Real time-PCR showed 1.7 fold higher expression of ABCG2 in PHPL supplemented medium (p = 0.03), and similar expression of p63 in HPL and PHPL supplemented medium compared to FBS medium. The proliferation assay showed that LSCs retained their proliferative potential in HPL supplemented medium. Higher concentration of growth factors were found in HPL, compared to HS. Human platelet lysate has higher concentration of grown factors and is effective in maintaining growth and stem cell phenotype of corneal limbal explant cultures.

  8. The effects of GH and hormone replacement therapy on serum concentrations of mannan-binding lectin, surfactant protein D and vitamin D binding protein in Turner syndrome

    DEFF Research Database (Denmark)

    Gravholt, Claus Højbjerg; Leth-Larsen, Rikke; Lauridsen, Anna Lis

    2004-01-01

    function. In the present study we examined whether GH or hormone replacement therapy (HRT) in Turner syndrome (TS) influence the serum concentrations of MBL and two other proteins partaking in the innate immune defence, surfactant protein D (SP-D) and vitamin D binding protein (DBP). DESIGN: Study 1...

  9. Cytokines and Bone Loss in a 5-Year Longitudinal Study—Hormone Replacement Therapy Suppresses Serum Soluble Interleukin-6 Receptor and Increases Interleukin-1-Receptor Antagonist

    DEFF Research Database (Denmark)

    Abrahamsen, B.; Bonnevie-Nielsen, V.; Ebbesen, E.N.

    2000-01-01

    ) and the soluble IL-6 receptor (sIL-6R) potentially modify cytokine bioactivity. We therefore assessed the impact of menopause and hormone replacement therapy (HRT) on cytokines and activity modifiers in serum within a 5-year longitudinal study. One hundred sixty perimenopausal women (age 50.1 +/- 2.8 years) were.......16; p = 0.17). In conclusion, serum IL-1ra and sIL-6R are influenced by HRT and are associated with the rate of bone loss in perimenopausal women....

  10. (99m) Tc-labelled human serum albumin cannot replace (125) I-labelled human serum albumin to determine plasma volume in patients with liver disease

    DEFF Research Database (Denmark)

    Henriksen, Ulrik Lütken; Henriksen, Jens H; Bendtsen, Flemming

    2013-01-01

    Summary Background and aims Determination of plasma volume (PV) is important in several clinical situations. Thus, patients with liver disease often have augmented PV as part of their sodium–water retention. This study was undertaken to compare PV determination by two indicators: technetium......-labelled human serum albumin (99mTc-HSA) and iodine-labelled human serum albumin (125I-HSA), as the former may have advantages at repeated measurements and the latter is the classical gold standard. Study population and methods In 88 patients, (64 with liver disease, mainly cirrhosis, and 24 patients without...... In all patients, a close correlation was present between PV determined by the two indicators (r = 0·89, Pdetermined with 99mTc-HSA exceeded PV determined with 125I-HSA by 367 ml (5·2 ml kg...

  11. Optimization of chemically defined cell culture media--replacing fetal bovine serum in mammalian in vitro methods

    DEFF Research Database (Denmark)

    van der Valk, J; Brunner, D; De Smet, K

    2010-01-01

    with an undefined and variable composition. Defined media supplements are commercially available for some cell types. However, information on the formulation by the companies is often limited and such supplements can therefore not be regarded as completely defined. The development of defined media is difficult......, reproducible and reduce the use of experimental animals. Good cell culture practice (GCCP) is an attempt to develop a common standard for in vitro methods. The implementation of the use of chemically defined media is part of the GCCP. This will decrease the dependence on animal serum, a supplement...... and often takes place in isolation. A workshop was organised in 2009 in Copenhagen to discuss strategies to improve the development and use of serum-free defined media. In this report, the results from the meeting are discussed and the formulation of a basic serum-free medium is suggested. Furthermore...

  12. Serum hepcidin-25 may replace the ferritin index in the Thomas plot in assessing iron status in anemic patients.

    Science.gov (United States)

    Thomas, C; Kobold, U; Balan, S; Roeddiger, R; Thomas, L

    2011-04-01

    Biochemical markers of iron deficiency do not distinguish iron-deficient anemia (IDA) from the anemia of chronic disease (ACD) and the combined state of ACD/IDA. Serum hepcidin-25 might be a marker resolving this problem. We investigated the extent to which serum hepcidin-25 enables the differentiation of the states above in comparison with the ferritin index plot, the so-called Thomas plot [soluble transferrin receptor (sTfR)/log ferritin and the reticulocyte hemoglobin content (CHr)]. Serum hepcidin-25 was determined in 155 anemic patients who were classified as having latent iron deficiency (latent ID), IDA, ACD, or ACD/IDA using the ferritin index plot (Thomas plot). Hepcidin-25 was determined using an isotope-dilution micro-HPLC-tandem mass spectrometry method. The ability to discriminate among these states based on serum hepcidin-25 alone or in combination with the CHr was evaluated in a receiver operating characteristic curve analysis and a comparison with the recently established ferritin index plot. Serum hepcidin-25 correlated with ferritin and the ferritin index. Use of a hepcidin-25 cutoff level of ≤4 nmol/l allowed the differentiation of IDA from ACD and ACD/IDA. Furthermore, the discrimination of ACD/IDA from ACD required combination with CHr in a new plot (hepcidin-25 and the CHr). The hepcidin-25 plot and the ferritin index plot showed a good correspondence in the differentiation of iron states in patients with anemia. Patients with IDA can be differentiated from ACD and ACD/IDA but not ACD from ACD/IDA based on hepcidin-25 alone. The combination of hepcidin-25 with CHr in the hepcidin-25 plot was useful for the differentiation of the states above. © 2010 Blackwell Publishing Ltd.

  13. Usefulness of Time-Point Serum Cortisol and ACTH Measurements for the Adjustment of Glucocorticoid Replacement in Adrenal Insufficiency.

    Science.gov (United States)

    Rousseau, Elise; Joubert, Michael; Trzepla, Géraldine; Parienti, Jean Jacques; Freret, Thomas; Vanthygem, Marie Christine; Desailloud, Rachel; Lefebvre, Hervé; Coquerel, Antoine; Reznik, Yves

    2015-01-01

    Adjustment of daily hydrocortisone dose on clinical criteria lacks sensitivity for fine tuning. Long term hydrocortisone (HC) over-replacement may lead to increased morbidity and mortality in patients with adrenal insufficiency (AI). Biochemical criteria may help detecting over- or under-replacement but have been poorly evaluated. Multicenter, institutional, pharmacokinetic study on ACTH and cortisol plasma profiles during HC replacement in 27 AI patients compared to 29 matched controls. All AI patients were administered HC thrice daily at doses of 6, 10 and 14 mg/m2/d. Blood samples were drawn hourly from 0800h to 1900h. The main outcome measures were: i) plasma peak cortisol and cortisol area under the curve (AUC) in AI patients compared to controls, ii) correlations between cortisol AUC vs single-point cortisol or ACTH decrease from baseline (ΔACTH) and iii) the predictive value of the two latters for obtaining AI patients' cortisol AUC in the control range. Cortisol peaks were observed 1h after each HC intake and a dose response was demonstrated for cortisol peak and cortisol AUC. The comparison of AI patients' cortisol AUC to controls showed that 81.5% AI patients receiving 6mg/m2/d were adequately replaced, whereas most patients receiving higher doses were over-replaced. The correlation coefficient between 1000h/1400h cortisol concentrations and 0800-1900h cortisol AUC were 0.93/0.88 respectively, whereas the 0800-1200h ΔACTH fairly correlated with 0800-1900h cortisol AUC (R = 0.57). ROC curve analysis indicated that the 1000h and 1400h cortisol concentrations best predicted over-replacement. Patients receiving a 6mg/m2 hydrocortisone daily dose exhibited the most physiological daytime cortisol profile. Single point plasma cortisol correlated with daytime cortisol AUC in AI patients. Although hydrocortisone dose should be currently determined on clinical grounds, our data suggest that single point plasma cortisol may be an adjunct for further hydrocortisone

  14. Serum estrogen and SHBG levels and breast cancer incidence among users and never users of hormone replacement therapy

    DEFF Research Database (Denmark)

    Würtz, Anne Mette Lund; Tjønneland, Anne; Christensen, Jane

    2012-01-01

    OBJECTIVE: Levels of endogenous estrogen and SHBG are associated with risk of breast cancer among women who have never used hormone replacement therapy (HRT). We investigated these associations in both never and baseline users of HRT. METHODS: A nested case-control study was conducted within the ...... and baseline HRT users. More studies are needed to support the findings for HRT users and to further investigate estrogen levels in relation to estrogen receptor-specific breast cancer and other histological and molecular subtypes.......OBJECTIVE: Levels of endogenous estrogen and SHBG are associated with risk of breast cancer among women who have never used hormone replacement therapy (HRT). We investigated these associations in both never and baseline users of HRT. METHODS: A nested case-control study was conducted within...... logistic regression yielded incidence rate ratios and 95 % confidence intervals for exposures analyzed continuously and categorically in models adjusted for potential confounders. RESULTS: Modest direct associations were identified between estrogen levels and breast cancer incidence among both never...

  15. Serum lactate level and mortality in metformin-associated lactic acidosis requiring renal replacement therapy: a systematic review of case reports and case series.

    Science.gov (United States)

    Yeh, Hung-Chieh; Ting, I-Wen; Tsai, Ching-Wei; Wu, Jenn-Yu; Kuo, Chin-Chi

    2017-07-10

    The current practice concerning timing, mode, and dose of renal replacement therapy (RRT) in patients with metformin-associated lactic acidosis (MALA) with renal failure remains unknown. To investigate whether serum lactate level and prescription pattern of RRT are associated with mortality in patients with MALA requiring RRT. We searched PubMed/Medline and EMBASE from inception to Sep 2014 and applied predetermined exclusion criteria. Case-level data including case's demographics and clinical information related to MALA were abstracted. Multiple logistic regression modeling was used to examine the predictors of mortality. A total of 253 unique cases were identified with cumulative mortality of 17.2%. Eighty-seven percent of patients had acute kidney injury. Serum lactate level was significantly higher in non-survivors (median 22.5 mmol/L) than in survivors (17.0 mmol/L, p-value optimal prescription of RRT in MALA, we recommend fostering an international consortium to support prospective research and large-scale standardized case collection.

  16. Gene-gene combination effect and interactions among ABCA1, APOA1, SR-B1, and CETP polymorphisms for serum high-density lipoprotein-cholesterol in the Japanese population.

    Directory of Open Access Journals (Sweden)

    Akihiko Nakamura

    Full Text Available BACKGROUND/OBJECTIVE: Gene-gene interactions in the reverse cholesterol transport system for high-density lipoprotein-cholesterol (HDL-C are poorly understood. The present study observed gene-gene combination effect and interactions between single nucleotide polymorphisms (SNPs in ABCA1, APOA1, SR-B1, and CETP in serum HDL-C from a cross-sectional study in the Japanese population. METHODS: The study population comprised 1,535 men and 1,515 women aged 35-69 years who were enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC Study. We selected 13 SNPs in the ABCA1, APOA1, CETP, and SR-B1 genes in the reverse cholesterol transport system. The effects of genetic and environmental factors were assessed using general linear and logistic regression models after adjusting for age, sex, and region. PRINCIPAL FINDINGS: Alcohol consumption and daily activity were positively associated with HDL-C levels, whereas smoking had a negative relationship. The T allele of CETP, rs3764261, was correlated with higher HDL-C levels and had the highest coefficient (2.93 mg/dL/allele among the 13 SNPs, which was statistically significant after applying the Bonferroni correction (p<0.001. Gene-gene combination analysis revealed that CETP rs3764261 was associated with high HDL-C levels with any combination of SNPs from ABCA1, APOA1, and SR-B1, although no gene-gene interaction was apparent. An increasing trend for serum HDL-C was also observed with an increasing number of alleles (p<0.001. CONCLUSIONS: The present study identified a multiplier effect from a polymorphism in CETP with ABCA1, APOA1, and SR-B1, as well as a dose-dependence according to the number of alleles present.

  17. Replacement of serum with sericin in in vitro maturation and culture media: Effects on embryonic developmental competence of Sanjabi sheep embryo during breeding season.

    Science.gov (United States)

    Hajarian, H; Aghaz, F; Karami Shabankareh, H

    2017-04-01

    Sericin is a water-soluble component of silk and has been used as a biomaterial due to its antibacterial and ultraviolet radiation-resistant properties. This study was designed to evaluate the effect of sericin supplementation, as a serum replacement, in maturation and culture media on the meiotic competence of oocytes or in vitro culture of ovine embryos. In experiment 1, oocytes were matured in the presence of 10% fetal ovine serum (FOS), 0.1% polyvinyl alcohol (PVA) and different concentrations of sericin (0.1, 0.5, 1 and 2.5%), for 24 h. The addition of 0.5% sericin to maturation medium increased the rates of maturation to metaphase II of oocytes compared with those in cultures with 0.1% PVA. Following fertilization, blastocyst development was higher for oocytes matured with 0.5% of sericin compared with 0.1% PVA. However, the rates of nuclear maturation of oocytes and blastocyst development under FOS and 0.5% sericin were not significantly different. In experiment 2, presumptive zygotes were cultured in the presence of 10% FOS, 0.1% PVA and different concentrations of sericin (0.1, 0.5, 1 and 2.5%), for 7-8 days. The addition of 0.5% sericin to culture medium increased the blastocyst rate compared with those in cultures without sericin or addition of 0.1% PVA and 10% FOS. These results indicate the feasibility of sericin as an alternative protein supplement for IVM and IVC in ovine oocytes and zygotes. Copyright © 2016. Published by Elsevier Inc.

  18. Human platelet lysate is a feasible candidate to replace fetal calf serum as medium supplement for blood vascular and lymphatic endothelial cells.

    Science.gov (United States)

    Hofbauer, Pablo; Riedl, Sabrina; Witzeneder, Karin; Hildner, Florian; Wolbank, Susanne; Groeger, Marion; Gabriel, Christian; Redl, Heinz; Holnthoner, Wolfgang

    2014-09-01

    As angiogenic and lymphangiogenic key players, endothelial cells (ECs) are promising candidates for vascular regenerative therapies. To culture ECs in vitro, fetal calf serum (FCS) is most often used. However, some critical aspects of FCS usage, such as possible internalization of xenogeneic proteins and prions, must be considered. Therefore, the aim of this project was to determine if human platelet lysate (hPL) is a suitable alternative to FCS as medium supplement for the culture of blood vascular and lymphatic endothelial cells. The usability of hPL was tested by analysis of endothelial surface marker expression, metabolic activity and vasculogenic potential of outgrowth ECs (OECs), human umbilical vein ECs (HUVECs), and lymphatic ECs (LECs). Expression of EC markers CD31, VEGFR2, VE-cadherin and CD146 did not differ significantly between the EC types cultured in FCS or hPL. In addition, OECs, HUVECs and LECs formed tube-like structures on Matrigel when cultured in hPL and FCS. With the use of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromid assays, we found that the metabolic activity of OECs and LECs was slightly decreased when hPL was used. However, HUVECs and LECs did not show a significant decrease in metabolic activity, and HUVECs showed a slightly higher activity at low seeding densities. The use of hPL on different EC types did not reveal any substantial negative effects on EC behavior. Thus, hPL appears to be a favorable candidate to replace FCS as a medium supplement in the culture of ECs. Copyright © 2014 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

  19. Ankle replacement

    Science.gov (United States)

    Ankle arthroplasty - total; Total ankle arthroplasty; Endoprosthetic ankle replacement; Ankle surgery ... Ankle replacement surgery is most often done while you are under general anesthesia. This means you will ...

  20. Thyroid hormone replacement therapy

    NARCIS (Netherlands)

    Wiersinga, W. M.

    2001-01-01

    Thyroid hormone replacement has been used for more than 100 years in the treatment of hypothyroidism, and there is no doubt about its overall efficacy. Desiccated thyroid contains both thyroxine (T(4)) and triiodothyronine (T(3)); serum T(3) frequently rises to supranormal values in the absorption

  1. Can serum hyaluronic acid replace simple non-invasive indexes to predict liver fibrosis in HIV/Hepatitis C coinfected patients?

    Directory of Open Access Journals (Sweden)

    Resino Salvador

    2010-08-01

    Full Text Available Abstract Background Hyaluronic acid (HA serum levels correlate with the histological stages of liver fibrosis in hepatitis C virus (HCV monoinfected patients, and HA alone has shown very good diagnostic accuracy as a non-invasive assessment of fibrosis and cirrhosis. The aim of this study was to evaluate serum HA levels as a simple non-invasive diagnostic test to predict hepatic fibrosis in HIV/HCV-coinfected patients and to compare its diagnostic performance with other previously published simple non-invasive indexes consisting of routine parameters (HGM-1, HGM-2, Forns, APRI, and FIB-4. Methods We carried out a cross-sectional study on 201 patients who all underwent liver biopsies and had not previously received interferon therapy. Liver fibrosis was determined via METAVIR score. The diagnostic accuracy of HA was assessed by area under the receiver operating characteristic curves (AUROCs. Results The distribution of liver fibrosis in our cohort was 58.2% with significant fibrosis (F≥2, 31.8% with advanced fibrosis (F≥3, and 11.4% with cirrhosis (F4. Values for the AUROC of HA levels corresponding to significant fibrosis (F≥2, advanced fibrosis (F≥3 and cirrhosis (F4 were 0.676, 0.772, and 0.863, respectively. The AUROC values for HA were similar to those for HGM-1, HGM-2, FIB-4, APRI, and Forns indexes. The best diagnostic accuracy of HA was found for the diagnosis of cirrhosis (F4: the value of HA at the low cut-off (1182 ng/mL excluded cirrhosis (F4 with a negative predictive value of 99% and at the high cut-off (2400 ng/mL confirmed cirrhosis (F4 with a positive predictive value of 55%. By utilizing these low and high cut-off points for cirrhosis, biopsies could have theoretically been avoided in 52.2% (111/201 of the patients. Conclusions The diagnostic accuracy of serum HA levels increases gradually with the hepatic fibrosis stage. However, HA is better than other simple non-invasive indexes using parameters easily available in

  2. Knee Replacement

    Science.gov (United States)

    Knee replacement is surgery for people with severe knee damage. Knee replacement can relieve pain and allow you to ... Your doctor may recommend it if you have knee pain and medicine and other treatments are not ...

  3. Report on Three IAEA Intercomparisons: 1) Determination of Potassium and Cs-137 in Animal Blood Serum (A-1); 2) Determination of Sr-90 and Ra-226 in Animal Bone Ash (A-3); 3) Determination of Sr-90, Cs-137, Na, K, Cs, Ca, Sr and Ba in Milk Powder (A-7)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1973-12-01

    The samples were made from fresh animal blood by separating the blood particles from the serum, stirring and subsequent spray drying. No spiking with active or inactive materials was made. Each participating laboratory received a 500 g sub-sample of the material. In the case of {sup 137}Cs-analysis, two of the laboratories submitted two different sets of results which were obtained by different analytical methods. Results were presented in separate tables for both elements.

  4. Optimization of 90Sr/89Sr measurements

    Directory of Open Access Journals (Sweden)

    Legarda F.

    2012-04-01

    Full Text Available One of the key points in the double measurement method for the measurement of both, 89Sr and 90Sr, by using a proportional counter is the choice of the times at which the measurements should be done. In this paper, the formulae to calculate the 89Sr and 90Sr detection limits in conditions of radioactive equilibrium between 90Y and 90Sr are derived, and an analysis of them as a function of the time between the two measurements is done. The choice for the time of the second measurement is going to depend on the desired quality of the results to be obtained.

  5. Replacing penalties

    Directory of Open Access Journals (Sweden)

    Vitaly Stepashin

    2017-01-01

    Full Text Available УДК 343.24The subject. The article deals with the problem of the use of "substitute" penalties.The purpose of the article is to identify criminal and legal criteria for: selecting the replacement punishment; proportionality replacement leave punishment to others (the formalization of replacement; actually increasing the punishment (worsening of legal situation of the convicted.Methodology.The author uses the method of analysis and synthesis, formal legal method.Results. Replacing the punishment more severe as a result of malicious evasion from serving accused designated penalty requires the optimization of the following areas: 1 the selection of a substitute punishment; 2 replacement of proportionality is serving a sentence other (formalization of replacement; 3 ensuring the actual toughening penalties (deterioration of the legal status of the convict. It is important that the first two requirements pro-vide savings of repression in the implementation of the replacement of one form of punishment to others.Replacement of punishment on their own do not have any specifics. However, it is necessary to compare them with the contents of the punishment, which the convict from serving maliciously evaded. First, substitute the punishment should assume a more significant range of restrictions and deprivation of certain rights of the convict. Second, the perfor-mance characteristics of order substitute the punishment should assume guarantee imple-mentation of the new measures.With regard to replacing all forms of punishment are set significant limitations in the application that, in some cases, eliminates the possibility of replacement of the sentence, from serving where there has been willful evasion, a stricter measure of state coercion. It is important in the context of the topic and the possibility of a sentence of imprisonment as a substitute punishment in cases where the original purpose of the strict measures excluded. It is noteworthy that the

  6. Knee Replacement

    Science.gov (United States)

    ... days. Medications prescribed by your doctor should help control pain. During the hospital stay, you'll be encouraged to move your ... exercise your new knee. After you leave the hospital, you'll continue physical ... mobility and a better quality of life. And most knee replacements can be ...

  7. Replacement rod

    International Nuclear Information System (INIS)

    Hatfield, S.C.

    1989-01-01

    This patent describes in an elongated replacement rod for use with fuel assemblies of the type having two end fittings connected by guide tubes with a plurality of rod and guide tube cell defining spacer grids containing rod support features and mixing vanes. The grids secured to the guide tubes in register between the end fittings at spaced intervals. The fuel rod comprising: an asymmetrically beveled tip; a shank portion having a straight centerline; and a permanently diverging portion between the tip and the shank portion

  8. Environmental 90Sr measurements

    Science.gov (United States)

    Paul, M.; Berkovits, D.; Cecil, L.D.; Feldstein, H.; Hershkowitz, A.; Kashiv, Y.; Vogt, S.

    1997-01-01

    90Sr (T1/2 = 28.5 years) is a long-lived radionuclide produced in nuclear fission. Fast radiochemical detection of 90Sr in environmental samples is not feasible using current analytical methods. Accelerator Mass Spectrometry (AMS) measurements of 90Sr were made with the Rehovot 14UD Pelletron accelerator at a terminal voltage of 11 or 12 MV using our standard detection system. Injection of hydride ions (SrH3-) was chosen owing to high beam intensity and low Coulomb explosion effects. 90Sr ions were identified and discriminated from isobaric 90Zr by measuring time of flight, total energy and three independent energy-loss signals in an ionization chamber. A reference sample and a ground-water sample were successfully measured. The detection limit determined for a laboratory blank by the residual counts in the 90Sr region is 90Sr/Sr = 3 ?? 10-13, corresponding in practice to (2-4) ?? 10790Sr atoms or about 0.5-1 pCi/L in environmental water samples.

  9. Shoulder replacement - discharge

    Science.gov (United States)

    Total shoulder arthroplasty - discharge; Endoprosthetic shoulder replacement - discharge; Partial shoulder replacement - discharge; Partial shoulder arthroplasty - discharge; Replacement - shoulder - discharge; Arthroplasty - shoulder - discharge

  10. Hip joint replacement

    Science.gov (United States)

    Hip arthroplasty; Total hip replacement; Hip hemiarthroplasty; Arthritis - hip replacement; Osteoarthritis - hip replacement ... Your hip joint is made up of 2 major parts. One or both parts may be replaced during surgery: ...

  11. Migration and distribution of 90Sr in soil

    International Nuclear Information System (INIS)

    Yang Juncheng; Zhu Yongyi; Chen Jingjian

    1993-01-01

    The migration and distribution of radionuclide 90 Sr were conducted by the analysis of 97 soil longitudinal sections under natural conditions and by pot experiments with fallout and 90 Sr solution, respectively. Spring wheat and rice were employed in the pot experiments. The result showed that the radionuclide 90 Sr was mainly accumulated in the topsoil 0-10 cm under both of the natural and laboratory conditions. The vertical distribution of 90 Sr in soil agreed with the power function, which obtained was Y = 75.78 X -0.527 ; r = -0.986; n = 97. The existing forms of 90 Sr from fallout in soil, only 0.02-0.03% was in a soluble form and 0.06-0.07% in non-replaceable form

  12. Transcatheter aortic valve replacement

    Science.gov (United States)

    ... gov/ency/article/007684.htm Transcatheter aortic valve replacement To use the sharing features on this page, please enable JavaScript. Transcatheter aortic valve replacement (TAVR) is surgery to replace the aortic valve. ...

  13. Hip Replacement Surgery

    Science.gov (United States)

    ... Outreach Initiative Breadcrumb Home Health Topics English Español Hip Replacement Surgery Basics In-Depth Download Download EPUB ... PDF What is it? Points To Remember About Hip Replacement Surgery Hip replacement surgery removes damaged or ...

  14. Nicotine replacement therapy

    Science.gov (United States)

    Smoking cessation - nicotine replacement; Tobacco - nicotine replacement therapy ... Before you start using a nicotine replacement product, here are some things to know: The more cigarettes you smoke, the higher the dose you may need to ...

  15. Defining line replaceable units

    NARCIS (Netherlands)

    Parada Puig, J. E.; Basten, R. J I

    2015-01-01

    Defective capital assets may be quickly restored to their operational condition by replacing the item that has failed. The item that is replaced is called the Line Replaceable Unit (LRU), and the so-called LRU definition problem is the problem of deciding on which item to replace upon each type of

  16. Physiological studies in heterozygous calcium sensing receptor (CaSR gene-ablated mice confirm that the CaSR regulates calcitonin release in vivo

    Directory of Open Access Journals (Sweden)

    Kovacs Christopher S

    2004-04-01

    Full Text Available Abstract Background The calcium sensing receptor (CaSR regulates serum calcium by suppressing secretion of parathyroid hormone; it also regulates renal tubular calcium excretion. Inactivating mutations of CaSR raise serum calcium and reduce urine calcium excretion. Thyroid C-cells (which make calcitonin express CaSR and may, therefore, be regulated by it. Since calcium stimulates release of calcitonin, the higher blood calcium caused by inactivation of CaSR should increase serum calcitonin, unless CaSR mutations alter the responsiveness of calcitonin to calcium. To demonstrate regulatory effects of CaSR on calcitonin release, we studied calcitonin responsiveness to calcium in normal and CaSR heterozygous-ablated (Casr+/- mice. Casr+/- mice have hypercalcemia and hypocalciuria, and live normal life spans. Each mouse received either 500 μl of normal saline or one of two doses of elemental calcium (500 μmol/kg or 5 mmol/kg by intraperitoneal injection. Ionized calcium was measured at baseline and 10 minutes, and serum calcitonin was measured on the 10 minute sample. Results At baseline, Casr+/- mice had a higher blood calcium, and in response to the two doses of elemental calcium, had greater increments and peak levels of ionized calcium than their wild type littermates. Despite significantly higher ionized calcium levels, the calcitonin levels of Casr+/- mice were consistently lower than wild type at any ionized calcium level, indicating that the dose-response curve of calcitonin to increases in ionized calcium had been significantly blunted or shifted to the right in Casr+/- mice. Conclusions These results confirm that the CaSR is a physiological regulator of calcitonin; therefore, in response to increases in ionized calcium, the CaSR inhibits parathyroid hormone secretion and stimulates calcitonin secretion.

  17. Serum sickness

    Science.gov (United States)

    ... the problem should be stopped. Avoid using that medicine or antiserum in the future. ... Call your provider if you received medicine or antiserum in the last 4 weeks and have symptoms of serum sickness.

  18. Review of SR 97

    International Nuclear Information System (INIS)

    Voss, C.I.

    2000-01-01

    The safety analysis conducted by SKB for SR 97 is impressive in terms of both scale and content. In addition to an eventual solution to Sweden's nuclear waste isolation question, much general scientific knowledge of real value in other applications will be created as a by-product of SKB's efforts. This review focuses on those geoscience aspects of SR 97 that have the most important effects on radionuclide release from each barrier. Indeed, SR 97 elucidates the most important geoscience parameters that control releases from the near field and the far field; these comprise mainly the transport resistance parameter, and the sorption coefficients for each nuclide, the matrix diffusion coefficient, and the Darcy flux. The Main Report is the most important document in SR 97 inasmuch as it is the only one that brings together all of the supporting work to answer the question of safety. Unfortunately pervading the good supporting work done is the impression that the Main Report is not balanced, that it emphasizes optimistic aspects and downplays the negative. SKB specifies 3 main requirements to guarantee proper repository function: a non-oxidizing subsurface environment, temperatures less than 100 C, and a mechanically stable low-permeability buffer surrounding the canisters. The first and third requirements are not thoroughly proven by SKB. One source of near-field doubt stems from the consequences of combinations of scenarios in which several negative events are linked, while the effect of each scenario is mainly evaluated only independently in SR 97. More pertinently, disastrous breakdown of complex systems may occur due to a chain of linked failures. For example, in the glacial scenario: high ground-water flow (possible ablation of buffer and high fluid transport), change in ground-water chemistry (even the possibility of oxidizing conditions), new flow paths, significant changes in mechanical stress and possible motion along faults (which may also generate new flow

  19. Ankle replacement - discharge

    Science.gov (United States)

    ... total - discharge; Total ankle arthroplasty - discharge; Endoprosthetic ankle replacement - discharge; Osteoarthritis - ankle ... You had an ankle replacement. Your surgeon removed and reshaped ... an artificial ankle joint. You received pain medicine and were ...

  20. Artificial Disc Replacement

    Science.gov (United States)

    ... Spondylolisthesis BLOG FIND A SPECIALIST Treatments Artificial Disc Replacement (ADR) Patient Education Committee Jamie Baisden The disc ... Disc An artificial disc (also called a disc replacement, disc prosthesis or spine arthroplasty device) is a ...

  1. Partial knee replacement - slideshow

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/presentations/100225.htm Partial knee replacement - series—Normal anatomy To use the sharing ... A.M. Editorial team. Related MedlinePlus Health Topics Knee Replacement A.D.A.M., Inc. is accredited ...

  2. Flued head replacement alternatives

    International Nuclear Information System (INIS)

    Smetters, J.L.

    1987-01-01

    This paper discusses flued head replacement options. Section 2 discusses complete flued head replacement with a design that eliminates the inaccessible welds. Section 3 discusses alternate flued head support designs that can drastically reduce flued head installation costs. Section 4 describes partial flued head replacement designs. Finally, Section 5 discusses flued head analysis methods. (orig./GL)

  3. Capital Equipment Replacement Decisions

    OpenAIRE

    Batterham, Robert L.; Fraser, K.I.

    1995-01-01

    This paper reviews the literature on the optimal replacement of capital equipment, especially farm machinery. It also considers the influence of taxation and capital rationing on replacement decisions. It concludes that special taxation provisions such as accelerated depreciation and investment allowances are unlikely to greatly influence farmers' capital equipment replacement decisions in Australia.

  4. Implementing Replacement Cost Accounting

    Science.gov (United States)

    1976-12-01

    cost accounting Clickener, John Ross Monterey, California. Naval Postgraduate School http://hdl.handle.net/10945/17810 Downloaded from NPS Archive...Calhoun IMPLEMENTING REPLACEMENT COST ACCOUNTING John Ross CHckener NAVAL POSTGRADUATE SCHOOL Monterey, California THESIS IMPLEMENTING REPLACEMENT COST ...Implementing Replacement Cost Accounting 7. AUTHORS John Ross Clickener READ INSTRUCTIONS BEFORE COMPLETING FORM 3. RECIPIENT’S CATALOG NUMBER 9. TYRE OF

  5. Decay of 83Sr

    International Nuclear Information System (INIS)

    Yu Xiaohan; Shi Shuanghui; Gu Jiahui

    1997-01-01

    The decay of 83 Sr was reinvestigated using γ singles and γ-γ-t coincidence measurement. A new level scheme of Rb, which contains 41 excited levels and about 180 transitions, is constructed. 19 new levels were added to the old level scheme and 8 formerly adopted levels were denied. A new data set of branching ratio, log(ft) value and spin parity was obtained

  6. Aeronautical Information System Replacement -

    Data.gov (United States)

    Department of Transportation — Aeronautical Information System Replacement is a web-enabled, automation means for the collection and distribution of Service B messages, weather information, flight...

  7. Web Page Content and Quality Assessed for Shoulder Replacement.

    Science.gov (United States)

    Matthews, John R; Harrison, Caitlyn M; Hughes, Travis M; Dezfuli, Bobby; Sheppard, Joseph

    2016-01-01

    The Internet has become a major source for obtaining health-related information. This study assesses and compares the quality of information available online for shoulder replacement using medical (total shoulder arthroplasty [TSA]) and nontechnical (shoulder replacement [SR]) terminology. Three evaluators reviewed 90 websites for each search term across 3 search engines (Google, Yahoo, and Bing). Websites were grouped into categories, identified as commercial or noncommercial, and evaluated with the DISCERN questionnaire. Total shoulder arthroplasty provided 53 unique sites compared to 38 websites for SR. Of the 53 TSA websites, 30% were health professional-oriented websites versus 18% of SR websites. Shoulder replacement websites provided more patient-oriented information at 48%, versus 45% of TSA websites. In total, SR websites provided 47% (42/90) noncommercial websites, with the highest number seen in Yahoo, compared with TSA at 37% (33/90), with Google providing 13 of the 33 websites (39%). Using the nonmedical terminology with Yahoo's search engine returned the most noncommercial and patient-oriented websites. However, the quality of information found online was highly variable, with most websites being unreliable and incomplete, regardless of search term.

  8. Consideration of the band-gap tunability of BaSi2 by alloying with Ca or Sr based on the electronic structure calculations

    International Nuclear Information System (INIS)

    Imai, Yoji; Watanabe, Akio

    2007-01-01

    The electronic structures and total energies of BaSi 2 -SrSi 2 and BaSi 2 -CaSi 2 systems have been calculated using the first-principle pseudopotential method to clarify the band gap tunability of BaSi 2 by alloying with Sr or Ca. From an energetic consideration of the compounds where all the Ba I sites or all the Ba II sites of the BaSi 2 lattice are preferentially replaced by Sr or Ca, it is expected that the Ba I site will be preferentially replaced by Sr rather than the Ba II sites. Compounds where all the Ba II sites are replaced by Sr or all the Ba II or all the Ba I sites are replaced by Ca are energetically unfavorable compared to the undissolved system of BaSi 2 and SrSi 2 or CaSi 2 . The effect of the addition of Sr or Ca into the BaSi 2 lattice on the gap value is different depending on the replaced sites of Ba. The replacement of Ba I site by Sr will broaden the band gap of BaSi 2 , which is consistent with the observed results

  9. Is the Modern Marine 87Sr/86Sr Cycle Balanced?

    Science.gov (United States)

    Peucker-Ehrenbrink, B.

    2017-12-01

    The marine 87Sr/86Sr record is one of the best-reconstructed isotope records with thousands of high quality measurements spanning the past 800 million years. It records a global signal of tectonic, biotic and climatic processes on Earth. Yet despite decades of research we still do not know whether the current marine Sr budget is in steady state. Studies of the marine 88Sr/86Sr record indicate that sources and sinks do not balance. The magnitude and isotope composition of the terrestrial inputs are being debated, and the magnitude and temporal variability of unradiogenic contributions are not well constrained. Here I provide a revised assessment of all continental sources of Sr to the ocean, including river runoff, submarine groundwater discharge (Beck et al., 2013), dissolution of riverine suspended matter in seawater and dissolution of volcanic ash deposited on the ocean (Jones et al., 2012). I contrast continental sources of Sr with estimates of marine sources of Sr to seawater, specifically high- and low-temperature submarine hydrothermal fluids, as well as diffusive diagenetic fluxes. Best current data imply that unradiogenic submarine hydrothermal inputs to seawater are insufficient to balance the flux of radiogenic continental Sr. The revised assessment of riverine contributions is based on Sr data for almost 230 rivers, an increasing amount of time-series data for such rivers, as well as river discharge and sediment flux data for more than 2000 rivers. Regional sampling biases have been corrected with the aid of digital bedrock maps, specifically along the western margin of North America, East Africa and the large drainage region of Arabia, India and SE Asia. Significant uncertainty in the chemical and isotopic compositions of runoff from Greenland and East Africa remains. The main uncertainty in the budget, however, is related to the possibility that modern rivers do not represent the pre-anthropogenic (natural) state of continental runoff (e.g. Ganges

  10. Radiation Source Replacement Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Griffin, Jeffrey W.; Moran, Traci L.; Bond, Leonard J.

    2010-12-01

    This report summarizes a Radiation Source Replacement Workshop in Houston Texas on October 27-28, 2010, which provided a forum for industry and researchers to exchange information and to discuss the issues relating to replacement of AmBe, and potentially other isotope sources used in well logging.

  11. Hypoparathyroidism: Replacement Therapy with Parathyroid Hormone

    Directory of Open Access Journals (Sweden)

    Lars Rejnmark

    2015-12-01

    Full Text Available Hypoparathyroidism (HypoPT is characterized by low serum calcium levels caused by an insufficient secretion of parathyroid hormone (PTH. Despite normalization of serum calcium levels by treatment with activated vitamin D analogues and calcium supplementation, patients are suffering from impaired quality of life (QoL and are at increased risk of a number of comorbidities. Thus, despite normalization of calcium levels in response to conventional therapy, this should only be considered as an apparent normalization, as patients are suffering from a number of complications and calcium-phosphate homeostasis is not normalized in a physiological manner. In a number of recent studies, replacement therapy with recombinant human PTH (rhPTH(1-84 as well as therapy with the N-terminal PTH fragment (rhPTH(1-34 have been investigated. Both drugs have been shown to normalize serum calcium while reducing needs for activated vitamin D and calcium supplements. However, once a day injections cause large fluctuations in serum calcium. Twice a day injections diminish fluctuations, but don't restore the normal physiology of calcium homeostasis. Recent studies using pump-delivery have shown promising results on maintaining normocalcemia with minimal fluctuations in calcium levels. Further studies are needed to determine whether this may improve QoL and lower risk of complications. Such data are needed before replacement with the missing hormone can be recommended as standard therapy.

  12. Could wind replace nuclear?

    International Nuclear Information System (INIS)

    2017-01-01

    This article aims at assessing the situation produced by a total replacement of nuclear energy by wind energy, while facing consumption demand at any moment, notably in December. The authors indicate the evolution of the French energy mix during December 2016, and the evolution of the rate between wind energy production and the sum of nuclear and wind energy production during the same month, and then give briefly some elements regarding necessary investments in wind energy to wholly replace nuclear energy. According to them, such a replacement would be ruinous

  13. Slab replacement maturity guidelines.

    Science.gov (United States)

    2014-04-01

    This study investigated the use of maturity method to determine early age strength of concrete in slab : replacement application. Specific objectives were (1) to evaluate effects of various factors on the compressive : maturity-strength relationship ...

  14. Partial knee replacement

    Science.gov (United States)

    ... good range of motion in your knee. The ligaments in your knee are stable. However, most people with knee arthritis have a surgery called a total knee arthroplasty (TKA). Knee replacement is most often done in people age 60 ...

  15. Carbohydrates as Fat Replacers.

    Science.gov (United States)

    Peng, Xingyun; Yao, Yuan

    2017-02-28

    The overconsumption of dietary fat contributes to various chronic diseases, which encourages attempts to develop and consume low-fat foods. Simple fat reduction causes quality losses that impede the acceptance of foods. Fat replacers are utilized to minimize the quality deterioration after fat reduction or removal to achieve low-calorie, low-fat claims. In this review, the forms of fats and their functions in contributing to food textural and sensory qualities are discussed in various food systems. The connections between fat reduction and quality loss are described in order to clarify the rationales of fat replacement. Carbohydrate fat replacers usually have low calorie density and provide gelling, thickening, stabilizing, and other texture-modifying properties. In this review, carbohydrates, including starches, maltodextrins, polydextrose, gums, and fibers, are discussed with regard to their interactions with other components in foods as well as their performances as fat replacers in various systems.

  16. Hip joint replacement - slideshow

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/presentations/100006.htm Hip joint replacement - series—Normal anatomy To use the ... to slide 5 out of 5 Overview The hip joint is made up of two major parts: ...

  17. Tool Inventory and Replacement

    Science.gov (United States)

    Bear, W. Forrest

    1976-01-01

    Vocational agriculture teachers are encouraged to evaluate curriculum offerings, the new trends in business and industry, and develop a master tool purchase and replacement plan over a 3- to 5-year period. (HD)

  18. Knee joint replacement

    Science.gov (United States)

    ... to make everyday tasks easier. Practice using a cane, walker , crutches , or a wheelchair correctly. On the ... ask your doctor Knee joint replacement - discharge Preventing falls Preventing falls - what to ask your doctor Surgical ...

  19. Product Platform Replacements

    DEFF Research Database (Denmark)

    Sköld, Martin; Karlsson, Christer

    2012-01-01

    . To shed light on this unexplored and growing managerial concern, the purpose of this explorative study is to identify operational challenges to management when product platforms are replaced. Design/methodology/approach – The study uses a longitudinal field-study approach. Two companies, Gamma and Omega...... replacement was chosen in each company. Findings – The study shows that platform replacements primarily challenge managers' existing knowledge about platform architectures. A distinction can be made between “width” and “height” in platform replacements, and it is crucial that managers observe this in order...... to challenge their existing knowledge about platform architectures. Issues on technologies, architectures, components and processes as well as on segments, applications and functions are identified. Practical implications – Practical implications are summarized and discussed in relation to a framework...

  20. The replacement research reactor

    International Nuclear Information System (INIS)

    Cameron, R.

    1999-01-01

    As a consequences of the government decision in September 1997. ANSTO established a replacement research reactor project to manage the procurement of the replacement reactor through the necessary approval, tendering and contract management stages This paper provides an update of the status of the project including the completion of the Environmental Impact Statement. Prequalification and Public Works Committee processes. The aims of the project, management organisation, reactor type and expected capabilities are also described

  1. Serum ferritin

    International Nuclear Information System (INIS)

    Rochna Viola, E.M.; Diaz de Domingo, N.B.; Lazarowski, A.

    1981-01-01

    Serum ferritin (SF) concentration as determined by the immunoradiometric method allows the direct measurement of a fraction of the body ferritin pool. In normal subjects, SF is an excellent index of body iron stores. In certain conditions associated with increased ferritin synthesis (such as liver disease, inflammation, malignancy, chronic disorders, ineffective erythropoiesis, or during ferrotherapy), SF may not accurately reflect body iron stores. In hyposideremic anemias SF concentration permits to differentiate those due to iron deficiency from those due to chronic disorders. With a good assay quality, subnormal SF levels are incontrovertible in the diagnosis of iron deficiency. SF determination has been investigated as possible tumor marker. When performed in combination with the alpha-fetoprotein assay, SF enhances the specificity of serodiagnosis of hepatoma. SF results must be interpreted bearing in mind the possible participation of circumstances that i) modify the body iron stores and ii) lead to increased ferritin synthesis. (author) [es

  2. Study on the mechanisms of solidification for Cs+ and Sr2+ in alkali-activated slag cement waste forms

    International Nuclear Information System (INIS)

    Yan Sheng; Shen Xiaodong; Lu Linchao; Wu Xuequan; Wen Yinghui

    1994-09-01

    The mechanisms of adsorption and chemical immobilization in Alkali-Activated Slag Cement (AASC) waste forms were quantitatively studied for Cs + and Sr 2+ . Experimental results show that, hardened AASC paste with zeolite and silica fume possesses strong adsorption ability and anti-desorption ability for Cs + and Sr 2+ . The results and analyzed by XRD show that CS + and SR 2+ could be incorporated into the lattice of C-S-H by replacing Ca 2+ in C-S-H. The d 111 values of C-S-H increase with increasing CsNO 3 and Sr(NO 3 ) 2 dosages in a limited and regular step. After washed out by deionized water in a ultrasonic washer, samples were analyzed by SEM-EDS and a lot of Cs + and Sr 2+ were detected. This means that the hydration products of AASC have a high retaining ability for Cs + and Sr 2+ . (3 tabs., 8 figs.)

  3. Coral Sr-U Thermometry

    Science.gov (United States)

    DeCarlo, T. M.; Gaetani, G. A.; Cohen, A. L.; Foster, G. L.; Alpert, A.; Stewart, J.

    2016-12-01

    Coral skeletons archive the past two millennia of climate variability in the oceans with unrivaled temporal resolution. However, extracting accurate temperature information from coral skeletons is confounded by "vital effects", which often override the temperature dependence of geochemical proxies. Here, we present a new approach to coral paleothermometry based on results of abiogenic precipitation experiments interpreted within a framework provided by a quantitative model of the coral biomineralization process. We conducted laboratory experiments to test the temperature and carbonate chemistry controls on abiogenic partitioning of Sr/Ca and U/Ca between aragonite and seawater, and we modeled the sensitivity of skeletal composition to processes occurring at the site of calcification. The model predicts that temperature can be accurately reconstructed from coral skeleton by combining Sr/Ca and U/Ca ratios into a new proxy, Sr-U. We tested the model predictions with measured Sr/Ca and U/Ca ratios of fourteen Porites sp. corals collected from the tropical Pacific Ocean and the Red Sea, with a subset also analyzed using the boron isotope (δ11B) pH proxy. Observed relationships among Sr/Ca, U/Ca, and δ11B agree with model predictions, indicating that the model accounts for the key features of the coral biomineralization process. We calibrated Sr-U to instrumental temperature records and found that it captures 93% of mean annual variability (26-30 °C) and predicts temperature within 0.5 °C (1 σ). Conversely, Sr/Ca alone has an error of prediction of 1 °C and often diverges from observed temperature by 3 °C or more. Many of the problems afflicting Sr/Ca - including offsets among neighboring corals and decouplings from temperature during coral stress events - are reconciled by Sr-U. By accounting for the influence of the coral biomineralization process, the Sr-U thermometer may offer significantly improved reliability for reconstructing ocean temperatures from coral

  4. Clinical study on postoperative steroid hormon replacement for preclinical Cushing's syndrome

    International Nuclear Information System (INIS)

    Furuta, Nozomu; Koide, Haruhisa; Sasaki, Hiroshi; Miki, Jun; Kimura, Takahiro; Egawa, Shin

    2009-01-01

    Diagnostic criteria for preclinical Cushing's syndrome (PCS) were reported in 1996. However, requirement of postoperative steroid hormone replacement is still controversial issue. In this study, we observed recent surgical cases retrospectively and evaluate the use of postoperative steroid hormone replacement. Eighteen patients with PCS underwent surgery from 1997 to 2007 in Jikei University Hospital. Thirteen of them received postoperative steroid hormone replacement. We investigated preoperative hormone activity by 131 I-adosterol scintigraphy and suppression of adrenocorticotropic hormone (ACTH) and evaluated the requirement of postoperative steroid hormone replacement. Preoperative serum cortisol was normal range in all patients. Serum ACTH was suppressed in 10 of them (56%). In 131 I-adosterol scintigraphy, accumulation in ipsilateral side was observed in all patients. Accumulation in contralateral side was observed in 13 patients whose serum ACTH had tendency to be suppressed. Mean period of steroid hormone replacement was 19.8 weeks. Patients with lower preoperative ACTH tended to require longer period until withdrawal of steroid hormone replacement. In addition, patients received steroid hormone replacement with higher starting dose significantly required longer period. Three of them had complications during tapering of steroid hormone. Postoperative adrenal insufficiency is important issue as postoperative management of PCS patients whose function of contralateral adrenal or pituitary gland is suppressed. 131 I-adosterol scintigraphy and preoperative serum ACTH were important factors to evaluate the requirement of postoperative steroid hormone replacement. Especially, patients with low preoperative serum ACTH tended to require long duration of postoperative steroid hormone replacement. On the other hand, patients with accumulation of contralateral side in 131 I-adosterol scintigraphy and without suppression of serum ACTH may not require steroid hormone

  5. Prioritizing equipment for replacement.

    Science.gov (United States)

    Capuano, Mike

    2010-01-01

    It is suggested that clinical engineers take the lead in formulating evaluation processes to recommend equipment replacement. Their skill, knowledge, and experience, combined with access to equipment databases, make them a logical choice. Based on ideas from Fennigkoh's scheme, elements such as age, vendor support, accumulated maintenance cost, and function/risk were used.6 Other more subjective criteria such as cost benefits and efficacy of newer technology were not used. The element of downtime was also omitted due to the data element not being available. The resulting Periop Master Equipment List and its rationale was presented to the Perioperative Services Program Council. They deemed the criteria to be robust and provided overwhelming acceptance of the list. It was quickly put to use to estimate required capital funding, justify items already thought to need replacement, and identify high-priority ranked items for replacement. Incorporating prioritization criteria into an existing equipment database would be ideal. Some commercially available systems do have the basic elements of this. Maintaining replacement data can be labor-intensive regardless of the method used. There is usually little time to perform the tasks necessary for prioritizing equipment. However, where appropriate, a clinical engineering department might be able to conduct such an exercise as shown in the following case study.

  6. Can photovoltaic replace nuclear?

    International Nuclear Information System (INIS)

    2017-01-01

    As the French law on energy transition for a green growth predicts that one third of nuclear energy production is to be replaced by renewable energies (wind and solar) by 2025, and while the ADEME proposes a 100 per cent renewable scenario for 2050, this paper proposes a brief analysis of the replacement of nuclear energy by solar photovoltaic energy. It presents and discusses some characteristics of photovoltaic production: production level during a typical day for each month (a noticeable lower production in December), evolution of monthly production during a year, evolution of the rate between nuclear and photovoltaic production. A cost assessment is then proposed for energy storage and for energy production, and a minimum cost of replacement of nuclear by photovoltaic is assessed. The seasonal effect is outlined, as well as the latitude effect. Finally, the authors outline the huge cost of such a replacement, and consider that public support to new photovoltaic installations without an at least daily storage mean should be cancelled

  7. Fluorescent Lamp Replacement Study

    Science.gov (United States)

    2017-07-01

    not be cited for purposes of advertisement. DISPOSITION INSTRUCTIONS: Destroy this document when no longer needed. Do not return to the... recycling , and can be disposed safely in a landfill. (2) LEDs offer reduced maintenance costs and fewer bulb replacements, significantly reducing... recycling . Several fixtures, ballasts and energy efficient fluorescent bulbs that were determined to be in pristine condition were returned to ATC

  8. Replacing Recipe Realism

    OpenAIRE

    Saatsi, J

    2017-01-01

    Many realist writings exemplify the spirit of ‘recipe realism’. Here I characterise recipe realism, challenge it, and propose replacing it with ‘exemplar realism’. This alternative understanding of realism is more piecemeal, robust, and better in tune with scientists’ own attitude towards their best theories, and thus to be preferred.

  9. Radioimmunoassay of thyrotropin concentrated from serum

    International Nuclear Information System (INIS)

    Nisula, B.C.; Louvet, J.P.

    1978-01-01

    A method for concentrating human TSH (hTSH) from serum for use in RIAs is described. The method takes advantage of the affinity of the plant lectin, concanavalin A, for the carbohydrate portion of the hTSH molecule. The hTSH from 2.5 ml serum was adsorbed to concanavalin A covalently linked to sepharose and then radioimmunoassayed using the hTSH antiserum and hTSH for iodination distributed by the National Pituitary Agency. For the RIA standard curve, the hTSH reference preparation was concentrated from a serum wwith undetectable hTSH in order to correct for recovery and to control for nonspecific effects. The percentage of serum hTSH extracted from 2.5 ml serum with the concentration procedure was 76.6 +- 3.4% (mean +- SD). The coefficient of correlation between serum hTSH, determined with the concentration procedure, and serum hTSH determined without was 0.979 (P < 0.001). Over 95% of normal adult men and women had detectable levels of serum hTSH, ranging from < 0.56 to 4.0 μU/ml. The mean of detectable serum hTSH levels in normal adult women (n = 11) was 1.54 +- 1.03 μU/ml (mean +- SD) and in normal men (n = 9) was 2.02 +- 1.15 μU/ml (mean +- SD). Clinically hyperthyroid patients with diffuse and nodular toxic goiters (n = 8) and patients with hypothyroidism secondary to pituitary disease (n = 6), four of whom were taking replacement doses of thyroid hormone, had undetectable serum hTSH levels. Serum hTSH in patients with primary hypothyroidism uniformly exceeded the normal range. This hTSH concentrating procedure enhances the effective sensitivity and, therefore, the clinical utility of the RIA for hTSH in serum

  10. Complexation studies with 90Y from a novel 90Sr-90Y generator

    International Nuclear Information System (INIS)

    Venkatesh, M.; Pandey, U.; Banerjee, S.; Samuel, G.; Pillai, M.R.A.; Dhami, P.S.; Kannan, R.; Achuthan, P.V.; Chitnis, R.R.; Gopalakrishnan, V.; Ramanujam, A.

    2001-01-01

    Some features of a novel 90 Sr- 90 Y generator which employs supported liquid membrane (SLM) to separate carrier-free 90 Y from 90 Sr present in the high level waste of the spent fuel of reactor are described. After ascertaining the purity of 90 Y particularly with respect to 90 Sr breakthrough, its complexation was studied with a few oxo/aza donor ligands, such as DTPA, EDTMP, DOTA, TETA and a cyclic phosphonate, CTMP. These studies were primarily carried out to adjudge the quality of the 90 Y obtained from a novel 90 Sr- 90 Y generator and ascertain its usability for labelling biomolecules such as antibodies and peptides. The DOTA complexes are most stable at 37 C in human serum; they appear to be ideal bifunctional chelating agent for use in radioimmunotherapy with 90 Y. (orig.)

  11. Renal replacement therapy in healthy adult horses.

    Science.gov (United States)

    Wong, D M; Witty, D; Alcott, C J; Sponseller, B A; Wang, C; Hepworth, K

    2013-01-01

    Renal replacement therapy (RRT) has been implemented extensively in people to facilitate recovery from acute renal failure (ARF). RRT has not been explored in horses, but might provide a further treatment option in horses with ARF. To investigate efficacy and safety of RRT in horses. Five healthy adult horses. A prospective study was performed on horses restrained in stocks and intravenously connected to a commercial RRT machine to allow continuous venovenous hemodiafiltration to be performed for 6 hours. The RRT machine was set at the following flow rates: blood flow rate 250 mL/min; dialysate rate 3,000 mL/h; prefilter replacement pump 3,000 mL/h; and postfilter replacement pump rate 2,000 mL/h. Balanced electrolyte solution was used as dialysate and replacement fluid. Heart rate, respiratory rate, body temperature, direct arterial blood pressure, urine output, and various clinicopathologic parameters were measured over the study period. Renal replacement therapy was successfully performed in horses, resulting in a mean creatinine clearance of 0.127 mL/kg/min (68.9 mL/min) and urea reduction ratio of 24%. No adverse effects were detected although a significant decrease in rectal temperature was observed (P ≤ .007). A significant increase in serum phosphorus (P ≤ .001) and decrease in BUN (P replacement therapy can safely and effectively be used in adult horses. Copyright © 2013 by the American College of Veterinary Internal Medicine.

  12. Synthetic clay excels in 90Sr removal

    International Nuclear Information System (INIS)

    Komarneni, Sridhar; Kodama, Tatsuya; Paulus, William J.; Carlson, C.

    2000-01-01

    Tests with actual ground water from Hanford site, and fundamental studies of 2Na + →Sr 2+ exchange equilibria revealed that a synthetic clay is extremely selective for 90 Sr with a high capacity for uptake. Comparative studies with existing Sr selective ion exchangers clearly revealed that the present synthetic clay exhibited the best performance for 90 Sr removal from actual ground water collected from three different locations at Hanford. This novel Sr ion sieve is expected to be useful for the decontamination of the environment after accidental release and contamination with 90 Sr. (c) 2000 Materials Research Society

  13. Effect of dietary citric acid supplementation and partial replacement ...

    African Journals Online (AJOL)

    Beluga is one of the most important fishes in Caspian Sea. The purpose of this experiment were to evaluate the effect of soybean meal (SBM) as a fishmeal (FM) partial replacement and citric acid (CA) supplement on the calcium (Ca) and phosphorus (P) of muscle, scute and serum of Beluga diets. Three isonitrogenous and ...

  14. EFFECT OF REPLACING COCOA HUSK FOR WHEAT BRAN ON ...

    African Journals Online (AJOL)

    Carcass yield, serum metabolites and economy of production of cockerels were studied for 12 weeks to determine the effect of replacing wheat bran with cocoa husk at 0, 25, 50, 75 and 100% levels. Results of eviscerated yield were statistically different (P<0.05). Highest eviscerated yield of 70.52% was obtained from 25% ...

  15. Glaucoma after corneal replacement.

    Science.gov (United States)

    Baltaziak, Monika; Chew, Hall F; Podbielski, Dominik W; Ahmed, Iqbal Ike K

    Glaucoma is a well-known complication after corneal transplantation surgery. Traditional corneal transplantation surgery, specifically penetrating keratoplasty, has been slowly replaced by the advent of new corneal transplantation procedures: primarily lamellar keratoplasties. There has also been an emergence of keratoprosthesis implants for eyes that are high risk of failure with penetrating keratoplasty. Consequently, there are different rates of glaucoma, pathogenesis, and potential treatment in the form of medical, laser, or surgical therapy. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. The replacement research reactor

    International Nuclear Information System (INIS)

    Cameron, R.; Horlock, K.

    2001-01-01

    The contract for the design, construction and commissioning of the Replacement Research Reactor was signed in July 2000. This was followed by the completion of the detailed design and an application for a construction licence was made in May 2001. This paper will describe the main elements of the design and their relation to the proposed applications of the reactor. The future stages in the project leading to full operation are also described

  17. Apparatus for fuel replacement

    International Nuclear Information System (INIS)

    Imada, Takahiko.

    1974-01-01

    Object: To support a telescope mast such that no deforming load is applied to it even during massive vibration, it is held fixed at the time of fuel replacement to permit satisfactory remote control operation by automatic operation. Structure: The body of the fuel replacement apparatus is provided with telescope mast fixing means comprising a slide base supported for reciprocal movement with respect to a telescope mast, an operating arm pivoted at the slide base, a wrist member mounted on the free end of the operating arm and an engagement member for restricting the slide base and operating arm at the time of loading and unloading the fuel. When loading and unloading the fuel, the slide base and operating arm are restrained by the engagement member to reliably restrict the vibration of the telescope mast. When the fuel replacement apparatus is moved, the means provided on the operating arm is smoothly displaced to follow the swing (vibration) of the telescope mast to prevent the deforming load from being applied to the support portion or other areas. The wrist member supports the telescope mast such that it can be rotated while restraining movement in the axial direction, and it is provided with revolution drive means for rotating the telescope mast under remote control. (Kamimura, M.)

  18. Internal bremsstrahlung from 89Sr and 90Sr

    International Nuclear Information System (INIS)

    Sayibaba, T.; Narasimha Murity, K.; Rao, C.R.; Satyaprakash; Gubbi, G.K.

    1987-01-01

    The internal bremsstrahlung (IB) spectra emitted in the beta-decays of 89 Sr and 90 Sr were measured with a HPGe detector and a multichannel analyser along with a standard geometrical set-up. Sufficient care has been taken to avoid spurious effects. After making all the necessary corrections, the experimental results were compared with the corresponding theoretical distributions due to Knipp and Uhlenbeck and Bloch (KUB), Lewis and Ford, Nilsson, and also due to Ford and Martin (detour theory). The total IB yields of intensity and energy from each of the isotopes in the investigated energy regions are also determined and compared with the corresponding theoretical values. The present results of IB from 89 Sr are satisfactorily accounted for by the KUB theory. In the case of 90 Sr the experimental results of IB coincide with the Coulomb-corrected theoretical distibution due to Nilsson in the energy range from 60 keV to 110 keV and Beyond 110 keV, they are found to be in excess over Nilsson's theory as well as the detour theory due to Ford and Martin up to the maximum photon energy studied, namely 350 keV

  19. Surfactant replacement therapy--economic impact.

    Science.gov (United States)

    Pejaver, R K; al Hifzi, I; Aldussari, S

    2001-06-01

    Surfactant replacement is an effective treatment for neonatal respiratory distress syndrome. (RDS). As widespread use of surfactant is becoming a reality, it is important to assess the economic implications of this new form of therapy. A comparison study was carried out at the Neonatal Intensive Care Unit (NICU) of Northwest Armed Forces Hospital, Saudi Arabia. Among 75 infants who received surfactant for RDS and similar number who were managed during time period just before the surfactant was available, but by set criteria would have made them eligible for surfactant. All other management modalities except surfactant were the same for all these babies. Based on the intensity of monitoring and nursing care required by the baby, the level of care was divided as: Level IIIA, IIIB, Level II, Level I. The cost per day per bed for each level was calculated, taking into account the use of hospital immovable equipment, personal salaries of nursing, medical, ancillary staff, overheads and maintenance, depreciation and replacement costs. Medications used, procedures done, TPN, oxygen, were all added to individual patient's total expenditure. 75 infants in the Surfactant group had 62 survivors. They spent a total of 4300 days in hospital. (av 69.35) Out of which 970 d (av 15.65 per patient) were ventilated days. There were 56 survivors in the non-surfactant group of 75. They had spent a total of 5023 days in the hospital (av 89.69/patient) out of which 1490 were ventilated days (av 26.60 d). Including the cost of surfactant (two doses), cost of hospital stay for each infant taking the average figures of stay would be SR 118, 009.75 per surfactant treated baby and SR 164, 070.70 per non-surfactant treated baby. The difference of 46,061 SR is 39.03% more in non-surfactant group. One Saudi rial = 8 Rs (approx at the time study was carried out.) Medical care cost varies from place to place. However, it is definitely cost-effective where surfactant is concerned. Quality adjusted

  20. Serum levels of nerve growth factor (NGF) in patients with major depression disorder and suicide risk.

    Science.gov (United States)

    Wiener, Carolina David; de Mello Ferreira, Sharon; Pedrotti Moreira, Fernanda; Bittencourt, Guilherme; de Oliveira, Jacqueline Flores; Lopez Molina, Mariane; Jansen, Karen; de Mattos Souza, Luciano Dias; Rizzato Lara, Diogo; Portela, Luiz Valmor; da Silva, Ricardo Azevedo; Oses, Jean Pierre

    2015-09-15

    Nerve growth factor (NGF) is an important member of the neurotrophins group and their involvement in the pathophysiology of major depression disorder (MDD) and suicide risk (SR) has been recently suggested. The aim of this study is to evaluate the changes in NGF serum levels in individuals with MDD and with or without risk of suicide, in subjects from a young population-based sample. This is a paired cross-sectional study nested in a population-based study. Individuals were rated for MDD and SR by a diagnostic interview--Mini International Neuropsychiatric Interview (M.I.N.I). The total population of the sample was comprised of 141 subjects distributed in three groups: 47 healthy controls, 47 subjects with current depressive episode without SR (MDD) and 47 subjects with current depressive episode and with SR (MDD + SR). NGF serum levels were significantly reduced in the MDD and MDD + SR groups when compared with controls (p ≤ 0.001). However, there were no differences in NGF levels between the MDD and MDD + SR groups (p = 1.000). These results suggest that reduced NGF serum levels can be a possible biomarker of MDD. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. The Rb-Sr system

    International Nuclear Information System (INIS)

    Graham, I.J.

    1983-11-01

    This manual is intended to serve as a guide to the chemical procedures involved in Rb-Sr isotopic analysis as conducted at the Institute of Nuclear Sciences. Included are notes on the experimental developments made over the last 2.5 years, especially those involving rock dissolution and cation exchange chromatography

  2. 90Sr in animal bones

    International Nuclear Information System (INIS)

    Kostadinov, K.

    1994-01-01

    90 Sr content in deer from Finland and Bulgaria, as well as cows and domestic pigs from Bulgaria has been investigated. The results obtained support an evaluation of the radioactive contamination of the biosphere in Bulgaria after the Chernobyl accident. (author)

  3. Toleration, Synthesis or Replacement?

    DEFF Research Database (Denmark)

    Holtermann, Jakob v. H.; Madsen, Mikael Rask

    2016-01-01

    , in order to answer is not yet another partisan suggestion, but rather an attempt at making intelligible both the oppositions and the possibilities of synthesis between normative and empirical approaches to law. Based on our assessment and rational reconstruction of current arguments and positions, we...... therefore outline a taxonomy consisting of the following three basic, ideal-types in terms of the epistemological understanding of the interface of law and empirical studies: toleration, synthesis and replacement. This tripartite model proves useful with a view to teasing out and better articulating...

  4. Upgrade, rebuild or replace?

    International Nuclear Information System (INIS)

    Forbes, C.A.

    1990-01-01

    Ageing reactor simulators present some tough decisions for utility managers. Although most utilities have chosen the cheaper, upgrading solution as the best compromise between costs and outage length, some US utilities have found that for them, replacement represents the best option. Simulators may be less than ten years old, but they have limited instructor systems, older low fidelity models that cannot reproduce important training scenarios, and out of date, difficult to maintain computers that do not permit much expansion of the models anyway. Perhaps worse than this is the possibility that the simulator may no longer be a faithful reproduction of the referenced plant, or have poor (or non-existent) documentation. (author)

  5. Electronic properties and surface reactivity of SrO-terminated SrTiO3 and SrO-terminated iron-doped SrTiO3.

    Science.gov (United States)

    Staykov, Aleksandar; Tellez, Helena; Druce, John; Wu, Ji; Ishihara, Tatsumi; Kilner, John

    2018-01-01

    Surface reactivity and near-surface electronic properties of SrO-terminated SrTiO 3 and iron doped SrTiO 3 were studied with first principle methods. We have investigated the density of states (DOS) of bulk SrTiO 3 and compared it to DOS of iron-doped SrTiO 3 with different oxidation states of iron corresponding to varying oxygen vacancy content within the bulk material. The obtained bulk DOS was compared to near-surface DOS, i.e. surface states, for both SrO-terminated surface of SrTiO 3 and iron-doped SrTiO 3 . Electron density plots and electron density distribution through the entire slab models were investigated in order to understand the origin of surface electrons that can participate in oxygen reduction reaction. Furthermore, we have compared oxygen reduction reactions at elevated temperatures for SrO surfaces with and without oxygen vacancies. Our calculations demonstrate that the conduction band, which is formed mainly by the d-states of Ti, and Fe-induced states within the band gap of SrTiO 3 , are accessible only on TiO 2 terminated SrTiO 3 surface while the SrO-terminated surface introduces a tunneling barrier for the electrons populating the conductance band. First principle molecular dynamics demonstrated that at elevated temperatures the surface oxygen vacancies are essential for the oxygen reduction reaction.

  6. Power Plant Replacement Study

    Energy Technology Data Exchange (ETDEWEB)

    Reed, Gary

    2010-09-30

    This report represents the final report for the Eastern Illinois University power plant replacement study. It contains all related documentation from consideration of possible solutions to the final recommended option. Included are the economic justifications associated with the chosen solution along with application for environmental permitting for the selected project for construction. This final report will summarize the results of execution of an EPC (energy performance contract) investment grade audit (IGA) which lead to an energy services agreement (ESA). The project includes scope of work to design and install energy conservation measures which are guaranteed by the contractor to be self-funding over its twenty year contract duration. The cost recovery is derived from systems performance improvements leading to energy savings. The prime focus of this EPC effort is to provide a replacement solution for Eastern Illinois University's aging and failing circa 1925 central steam production plant. Twenty-three ECMs were considered viable whose net impact will provide sufficient savings to successfully support the overall project objectives.

  7. Cadmium plating replacements

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, M.J.; Groshart, E.C.

    1995-03-01

    The Boeing Company has been searching for replacements to cadmium plate. Two alloy plating systems seem close to meeting the needs of a cadmium replacement. The two alloys, zinc-nickel and tin-zinc are from alloy plating baths; both baths are neutral pH. The alloys meet the requirements for salt fog corrosion resistance, and both alloys excel as a paint base. Currently, tests are being performed on standard fasteners to compare zinc-nickel and tin-zinc on threaded hardware where cadmium is heavily used. The Hydrogen embrittlement propensity of the zinc-nickel bath has been tested, and just beginning for the tin-zinc bath. Another area of interest is the electrical properties on aluminum for tin-zinc and will be discussed. The zinc-nickel alloy plating bath is in production in Boeing Commercial Airplane Group for non-critical low strength steels. The outlook is promising that these two coatings will help The Boeing Company significantly reduce its dependence on cadmium plating.

  8. REPLACEMENT OF FRENCH CARDS

    CERN Multimedia

    Human Resources Division

    2001-01-01

    The French Ministry of Foreign Affairs has informed the Organization that it is shortly to replace all diplomatic cards, special cards and employment permits ('attestations de fonctions') now held by members of the personnel and their families. Between 2 July and 31 December 2001, these cards are to be replaced by secure, computerized equivalents. A 'personnel office' stamped photocopy of the old cards may continue to be used until 31 December 2001. For the purposes of the handover, members of the personnel must go personally to the cards office (33/1-015), between 8:30 and 12:30, in order to fill a 'fiche individuelle' form (in black ink only), which has to be personally signed by themselves and another separately signed by members of their family, taking the following documents for themselves and members of their families already in possession of a French card : A recent identity photograph in 4.5 cm x 3.5 cm format (signed on the back) The French card in their possession an A4 photocopy of the same Fre...

  9. Power Plant Replacement Study

    Energy Technology Data Exchange (ETDEWEB)

    Reed, Gary

    2010-09-30

    This report represents the final report for the Eastern Illinois University power plant replacement study. It contains all related documentation from consideration of possible solutions to the final recommended option. Included are the economic justifications associated with the chosen solution along with application for environmental permitting for the selected project for construction. This final report will summarize the results of execution of an EPC (energy performance contract) investment grade audit (IGA) which lead to an energy services agreement (ESA). The project includes scope of work to design and install energy conservation measures which are guaranteed by the contractor to be self-funding over its twenty year contract duration. The cost recovery is derived from systems performance improvements leading to energy savings. The prime focus of this EPC effort is to provide a replacement solution for Eastern Illinois University’s aging and failing circa 1925 central steam production plant. Twenty-three ECMs were considered viable whose net impact will provide sufficient savings to successfully support the overall project objectives.

  10. Rapid method for determining Sr-89 and Sr-90 using Cherenkov and proportional counting; Schnellmethode zur Bestimmung von SR-89 und SR-90 durch Cerenkov- und Proportionalzaehlermessungen

    Energy Technology Data Exchange (ETDEWEB)

    Lange, S.; Wende, C.; Schwokowski, R.; Alisch-Mark, M.; Abraham, A.; Heinrich, T. [Staatliche Betriebsgesellschaft fuer Umwelt und Landwirtschaft, Radebeul (Germany)

    2016-07-01

    A rapid method for determining Sr-89 and Sr-90 in water, milk and biological samples has been developed and tested. After sample preparation strontium is separated by extraction chromatography using Sr resin. Eluate is divided and transfered to LSC vial and filter paper by SrCO{sub 3} precipitation. A Hidex 300 SL TDCR liquid scintillation counter and Thermo Fisher low level proportional counter have been used. Chemical yield of Sr-85 tracer is determined by Gamma spectroscopy. Uncertainty budget, decision threshold and detection limit are calculated in accordance with GUM and ISO 11929.

  11. Transdermal testosterone replacement therapy in men

    Directory of Open Access Journals (Sweden)

    Ullah MI

    2014-01-01

    Full Text Available M Iftekhar Ullah,1 Daniel M Riche,1,2 Christian A Koch1,31Department of Medicine, University of Mississippi Medical Center, 2Department of Pharmacy Practice, The University of Mississippi, 3GV (Sonny Montgomery VA Medical Center, Jackson, MS, USAAbstract: Androgen deficiency syndrome in men is a frequently diagnosed condition associated with clinical symptoms including fatigue, decreased libido, erectile dysfunction, and metabolic syndrome. Serum testosterone concentrations decline steadily with age. The prevalence of androgen deficiency syndrome in men varies depending on the age group, known and unknown comorbidities, and the respective study group. Reported prevalence rates may be underestimated, as not every man with symptoms of androgen deficiency seeks treatment. Additionally, men reporting symptoms of androgen deficiency may not be correctly diagnosed due to the vagueness of the symptom quality. The treatment of androgen deficiency syndrome or male hypogonadism may sometimes be difficult due to various reasons. There is no consensus as to when to start treating a respective man or with regards to the best treatment option for an individual patient. There is also lack of familiarity with treatment options among general practitioners. The formulations currently available on the market are generally expensive and dose adjustment protocols for each differ. All these factors add to the complexity of testosterone replacement therapy. In this article we will discuss the general indications of transdermal testosterone replacement therapy, available formulations, dosage, application sites, and recommended titration schedule.Keywords: hypogonadism, transdermal, testosterone, sexual function, testosterone replacement therapy, estradiol

  12. Replace with abstract title

    Science.gov (United States)

    Coho, Aleksander; Kioussis, Nicholas

    2003-03-01

    We use the semidiscrete variational generelized Peierls-Nabarro model to study the effect of Cu alloying on the dislocation properties of Al. First-principles density functional theory (DFT) is used to calculate the generalized-stacking-fault (GSF) energy surface when a plane, on which one in four Al atoms has been replaced with a Cu atom, slips over a pure Al plane. Various dislocation core properties (core width, energy, Peierls stress, dissociation tendency) are investigated and compared with the pure Al case. Cu alloying lowers the intrinsic stacking fault (ISF) energy, which makes dislocations more likely to dissociate into partials. We also try to understand the lowering of ISF energy in terms of Al-Cu and Al-Al bond formation and braking during shearing along the direction. From the above we draw conclusions about the effects of Cu alloying on the mechanical properties of Al.

  13. Iron replacement therapy

    DEFF Research Database (Denmark)

    Nielsen, Ole Haagen; Coskun, Mehmet; Weiss, Günter

    2016-01-01

    PURPOSE OF REVIEW: Approximately, one-third of the world's population suffers from anemia, and at least half of these cases are because of iron deficiency. With the introduction of new intravenous iron preparations over the last decade, uncertainty has arisen when these compounds should...... be administered and under which circumstances oral therapy is still an appropriate and effective treatment. RECENT FINDINGS: Numerous guidelines are available, but none go into detail about therapeutic start and end points or how iron-deficiency anemia should be best treated depending on the underlying cause...... of iron deficiency or in regard to concomitant underlying or additional diseases. SUMMARY: The study points to major issues to be considered in revisions of future guidelines for the true optimal iron replacement therapy, including how to assess the need for treatment, when to start and when to stop...

  14. Total ankle joint replacement.

    Science.gov (United States)

    2016-02-01

    Ankle arthritis results in a stiff and painful ankle and can be a major cause of disability. For people with end-stage ankle arthritis, arthrodesis (ankle fusion) is effective at reducing pain in the shorter term, but results in a fixed joint, and over time the loss of mobility places stress on other joints in the foot that may lead to arthritis, pain and dysfunction. Another option is to perform a total ankle joint replacement, with the aim of giving the patient a mobile and pain-free ankle. In this article we review the efficacy of this procedure, including how it compares to ankle arthrodesis, and consider the indications and complications. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  15. Protein electrophoresis - serum

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/003540.htm Protein electrophoresis - serum To use the sharing features on ... JavaScript. This lab test measures the types of protein in the fluid (serum) part of a blood ...

  16. Function modification of SR-PSOX by point mutations of basic amino acids

    Directory of Open Access Journals (Sweden)

    Chen Chunxia

    2011-04-01

    Full Text Available Abstract Background Atherosclerosis (AS is a common cardiovascular disease. Transformation of macrophages to form foam cells by internalizing modified low density-lipoprotein (LDL via scavenger receptor (SR is a key pathogenic process in the onset of AS. It has been demonstrated that SR-PSOX functions as either a scavenger receptor for uptake of atherogenic lipoproteins and bacteria or a membrane-anchored chemokine for adhesion of macrophages and T-cells to the endothelium. Therefore, SR-PSOX plays an important role in the development of AS. In this study the key basic amino acids in the chemokine domain of SR-PSOX have been identified for its functions. Results A cell model to study the functions of SR-PSOX was successfully established. Based on the cell model, a series of mutants of human SR-PSOX were constructed by replacing the single basic amino acid residue in the non-conservative region of the chemokine domain (arginine 62, arginine 78, histidine 80, arginine 82, histidine 85, lysine 105, lysine 119, histidine 123 with alanine (designated as R62A, R78A, H80A, R82A, H85A, K105A, K119A and H123A, respectively. Functional studies showed that the mutants with H80A, H85A, and K105A significantly increased the activities of oxLDL uptake and bacterial phagocytosis compared with the wild-type SR-PSOX. In addition, we have also found that mutagenesis of either of those amino acids strongly reduced the adhesive activity of SR-PSOX by using a highly non-overlapping set of basic amino acid residues. Conclusion Our study demonstrates that basic amino acid residues in the non-conservative region of the chemokine domain of SR-PSOX are critical for its functions. Mutation of H80, H85, and K105 is responsible for increasing SR-PSOX binding with oxLDL and bacteria. All the basic amino acids in this region are important in the cells adhesion via SR-PSOX. These findings suggest that mutagenesis of the basic amino acids in the chemokine domain of SR-PSOX may

  17. Serum iron test

    Science.gov (United States)

    Fe+2; Ferric ion; Fe++; Ferrous ion; Iron - serum; Anemia - serum iron; Hemochromatosis - serum iron ... A blood sample is needed. Iron levels are highest in the morning. Your health care provider will likely have you do this test in the morning.

  18. Antenna Controller Replacement Software

    Science.gov (United States)

    Chao, Roger Y.; Morgan, Scott C.; Strain, Martha M.; Rockwell, Stephen T.; Shimizu, Kenneth J.; Tehrani, Barzia J.; Kwok, Jaclyn H.; Tuazon-Wong, Michelle; Valtier, Henry; Nalbandi, Reza; hide

    2010-01-01

    The Antenna Controller Replacement (ACR) software accurately points and monitors the Deep Space Network (DSN) 70-m and 34-m high-efficiency (HEF) ground-based antennas that are used to track primarily spacecraft and, periodically, celestial targets. To track a spacecraft, or other targets, the antenna must be accurately pointed at the spacecraft, which can be very far away with very weak signals. ACR s conical scanning capability collects the signal in a circular pattern around the target, calculates the location of the strongest signal, and adjusts the antenna pointing to point directly at the spacecraft. A real-time, closed-loop servo control algorithm performed every 0.02 second allows accurate positioning of the antenna in order to track these distant spacecraft. Additionally, this advanced servo control algorithm provides better antenna pointing performance in windy conditions. The ACR software provides high-level commands that provide a very easy user interface for the DSN operator. The operator only needs to enter two commands to start the antenna and subreflector, and Master Equatorial tracking. The most accurate antenna pointing is accomplished by aligning the antenna to the Master Equatorial, which because of its small size and sheltered location, has the most stable pointing. The antenna has hundreds of digital and analog monitor points. The ACR software provides compact displays to summarize the status of the antenna, subreflector, and the Master Equatorial. The ACR software has two major functions. First, it performs all of the steps required to accurately point the antenna (and subreflector and Master Equatorial) at the spacecraft (or celestial target). This involves controlling the antenna/ subreflector/Master-Equatorial hardware, initiating and monitoring the correct sequence of operations, calculating the position of the spacecraft relative to the antenna, executing the real-time servo control algorithm to maintain the correct position, and

  19. Rapid determination of 90Sr in seawater

    International Nuclear Information System (INIS)

    Pavlotskaya, F.I.; Moskin, A.I.

    1994-01-01

    A method for determining 90 Sr in seawater that is based on direct isolation and radiochemical purification of daughter 90 Y is proposed. The analysis time is 6-8 h. The chemical yield of the Y-carrier during the 90 Sr determination from 35 liters of seawater varies in the range 37-69%. The analysis uncertainty is 90 Sr from seawater and subsequent isolation of 90 Y

  20. Risk factors for renal dysfunction after total hip joint replacement

    DEFF Research Database (Denmark)

    Hassan, Basim Kamil; Sahlström, Arne; Dessau, Ram Benny Christian

    2015-01-01

    BACKGROUND AND PURPOSE OF THE STUDY: Renal injury and dysfunction are serious complications after major surgery, which may lead to increased morbidity and mortality. The objective of our study was to identify the possible risk factors for renal dysfunction after total hip joint replacement surger...... creatinine. Smoking, diabetes mellitus, high BMI, gender, and duration of surgery were not identified as significant risk factors........ METHODS: A retrospective study was conducted among 599 consecutive primary hip joint replacements performed between January 2011 and December 2013. According to the RIFLE criteria, increased postoperative serum creatinine was considered indicative of postoperative renal injury. The Welch two-sample test......, hypertension, general anesthesia, high ASA scores, low intra-operative systolic BP, and prophylactic dicloxacillin as significant risk factors. Low baseline systolic BP, low baseline diastolic blood pressure, and hip fracture diagnosis were independent risk factors for postoperative increase in serum...

  1. Measurement of resonance integral of the 90Sr(n,γ)91Sr reaction

    International Nuclear Information System (INIS)

    Nakamura, Shoji; Furutaka, Kazuyoshi; Wada, Hiroaki; Katoh, Toshio; Harada, Hideo; Fujii, Toshiyuki; Yamana, Hajimu

    2001-01-01

    To obtain fundamental data for research on nuclear transmutation method of radioactive wastes, the resonance integral (I 0 ) of the 90 Sr(n,γ) 91 Sr reaction was measured with an activation method. (author)

  2. Isotope ratio 87Sr/86Sr in limestones from Bambui group, Brazil (MG)

    International Nuclear Information System (INIS)

    Kawashita, K.; Mizusaki, A.M.P.; Kiang, C.H.

    1987-01-01

    The Sr composition of ancient seawater can be estimated from the analysis of carbonate rocks and, in some cases, used to estimate the age of the analyzed carbonate. The normalized 87Sr/86Sr ratios in calcium carbonate fractions from 14 core samples in the Bambui Group near Montalvania, MG, were found to range between .7077 and .7280. The higher values are attributable to Sr isotopic exchange between silicate and carbonate phases during diagenesis. The ratio of .7077 obtained in two pure calcium carbonate samples is here suggested as the best aproximation for the 87Sr/86Sr value for the Bambui sea. This ratio is compatible with an age of about 700 Ma., estimated from the published 87Sr/86Sr curve of Veizer and others, an age in accordance with Quadros recent (1987, in preparation) identification of marine acritarchs from the latest Precambrian (Vendian). (author) [pt

  3. Separation of 90Y from 90Sr by solvent extraction with ionizable crown ethers

    International Nuclear Information System (INIS)

    Wood, D.J.; Elshani, S.; Du, H.S.; Natale, N.R.; Wai, C.M.

    1993-01-01

    Sym-Dibenzo-16-crown-5-oxyacetic acid and its analogues are selective for the extraction of Y 3+ over Sr 2+ from aqueous solutions into chloroform. The selectivity and the pH range of extraction are influenced by the structure of the ligand. The size of the macrocyclic cavity, the tether length of the lariat, the attachment of alkyl functional groups to the lariat, and the identity of the ionizable group can affect selectivity and extraction efficiency. When the carboxylic acid at the terminal end of the lariat is replaced by a hydroxamic acid, the selectivity for Y 3+ over Sr 2+ is significantly increased. Using these ionizable crown ethers as extractants, 90 Y fractions of greater than 99.9% purity can be obtained in a single solvent extraction step from solutions of 90 Sr. 11 refs., 5 figs., 2 tabs

  4. Preparation of 90Sr-90Y generator

    International Nuclear Information System (INIS)

    Jin Xiaohai; Yu Haibin; Zhang Jinming; Zhang Peixin; Lin Qiongfang

    1990-01-01

    In recent years, 90 Y has been considered as one of the best radionuclides for tumor radioimmunotherapy when chelated to tumor-associated antibodies. This evaluation is based on the superior properties of this radionuclide (suitable half-life, pure β-ray emitter of intermediate energy, stable daughters, and suitable chemical properties) and because it is available as a radionuclide generator product by decay of its 28a parent 90 Sr. The experimental conditions of 90 Sr- 90 Y generator are described. The elution efficiency of 90 Sr- 90 Y generator reaches 98%. One of the most important problems is the 90 Sr contamination breakthrough from the generator. The level of 90 Sr contamination must be controlled to the clinical standard. The cation exchange resin 732 (100-150 mesh) was successfully used for the separation of 90 Y from 90 Sr. The method used by the authors provides a 90 Y-HAc solution which is very simple and safe for administration to the patients. 90 Y was separated from 90 Sr almost completely, the level of the 90 Sr contamination per 740 MBq 90 Y product was only 0.74 kBq. However the toxicity of 90 Sr is extremely high, the human life-time permissible dose is 74 kBq, then 740 MBq of 90 Y is allowed to be administrated to a patient for 50-100 times

  5. Chernobyl 90Sr in bilberries from Poland

    International Nuclear Information System (INIS)

    Mietelski, J.W.; Vajda, N.

    1997-01-01

    As part of a detailed survey on the contamination of Polish forests 90 Sr activity concentrations were determined in bilberries. Elevated 90 Sr levels were found in several samples from north-eastern Poland. The calculated maximum 90 Sr surface contamination was 2 kBq*m -2 . The correlation between 90 Sr and 137 Cs concentrations in bilberries was good for two sets of samples originating from two geographical areas of Poland indicating the local differences in radionuclide depositions from Chernobyl fallout. (author)

  6. Experiences with the determination of Sr-89 and Sr-90 using fast methods; Erfahrungen bei der Bestimmung von {sup 89}Sr und {sup 90}Sr mittels Schnellmethoden

    Energy Technology Data Exchange (ETDEWEB)

    Kowalik, C.; Fueger, J. [Thueringer Landesanstalt fuer Umwelt und Geologie, Jena (Germany). Landesmessstelle fuer Umweltradioaktivaet

    2014-01-20

    Quick methods of the measurement of {sup 89}Sr and {sup 90}Sr have a great importance in the supervision of the environmental radioactivity. It is necessary to receive in short time dependable analytical data to be able to carry out suitable assessments or to give recommendations. The aim of the investigations was to be guaranteed the demands for these methods (test preparation, measurement and evaluation). The use of the solid phase extraction by means of commercial Sr Resin trademark columns (4.4' (5')-Di-tert-butylcyclohexanol-18-kronen-6-aether) (Triskem) to the radiochemical separation of the Sr isotopes was suitable. The measurements occurred to the FHT 770 T12 - Multi Low Level Alpha/Beta Sample Counter (Thermo Scientific). The results contain the summary activities of all available Sr isotopes, as for example {sup 89}Sr and {sup 90}Sr. The calculations of the single activities occur about the mathematical algorithm of the linear development on the basis of the works of G. Kanisch. The first results show, this method is suitable for the analysis of {sup 89}Sr and {sup 90}Sr and is used therefore in future in Thuringia.

  7. Hip Replacement: MedlinePlus Health Topic

    Science.gov (United States)

    ... invasive hip replacement (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Hip Replacement updates ... replacement - precautions Minimally invasive hip replacement Related Health Topics Hip Injuries and Disorders National Institutes of Health ...

  8. Educating My Replacement

    Science.gov (United States)

    Tarter, Jill

    , in partnership with the dedicated teachers out there, I think I can help promote the critical thinking skills and scientific literacy of the next generation of voters. Hopefully, I can also help train my replacement to be a better scientist, capable of seizing all the opportunities generated by advances in technology and our improved understanding of the universe to craft search strategies with greater probability of success than those I have initiated.

  9. Effect of Wood Aging on Wine Mineral Composition and 87Sr/86Sr Isotopic Ratio.

    Science.gov (United States)

    Kaya, Ayse D; Bruno de Sousa, Raúl; Curvelo-Garcia, António S; Ricardo-da-Silva, Jorge M; Catarino, Sofia

    2017-06-14

    The evolution of mineral composition and wine strontium isotopic ratio 87 Sr/ 86 Sr (Sr IR) during wood aging were investigated. A red wine was aged in stainless steel tanks with French oak staves (Quercus sessiliflora Salisb.), with three industrial scale replicates. Sampling was carried out after 30, 60, and 90 days of aging, and the wines were evaluated in terms of general analysis, phenolic composition, total polysaccharides, multielement composition, and Sr IR. Li, Be, Mg, Al, Sc, Ti, V, Mn, Co, Ni, Cu, Zn, Ga, Ge, As, Rb, Sr, Y, Zr, Mo, Sb, Cs, Ba, Pr, Nd, Sm, Eu, Dy, Ho, Er, Yb, Lu, Tl, and Pb elements and 87 Sr/ 86 Sr were determined by quadrupole inductively coupled plasma mass spectrometry (Q-ICP-MS) and Na, K, Ca, and Fe by flame atomic absorption spectrometry (FAAS). Two-way ANOVA was applied to assess wood aging and time effect on Sr IR and mineral composition. Wood aging resulted in significantly higher concentrations of Mg, V, Co, Ni, and Sr. At the end of the aging period, wine exhibited statistically identical Sr IR compared to control. Study suggests that wood aging does not affect 87 Sr/ 86 Sr, not precluding the use of this parameter for wine traceability purposes.

  10. Potassium toxicity at low serum potassium levels with refeeding syndrome.

    Science.gov (United States)

    Vemula, Praveen; Abela, Oliver G; Narisetty, Keerthy; Rhine, David; Abela, George S

    2015-01-01

    Refeeding syndrome is a life-threatening condition occurring in severely malnourished patients after initiating feeding. Severe hypophosphatemia with reduced adenosine triphosphate production has been implicated, but little data are available regarding electrolyte abnormalities. In this case, we report electrocardiographic changes consistent with hyperkalemia during potassium replacement after a serum level increase from 1.9 to 2.9 mEq/L. This was reversed by lowering serum potassium back to 2.0 mEq/L. In conclusion, the patient with prolonged malnutrition became adapted to low potassium levels and developed potassium toxicity with replacement. Copyright © 2015 Elsevier Inc. All rights reserved.

  11. Joint effect of 90Sr, alcohol and smoking on some immunological indices

    International Nuclear Information System (INIS)

    Shubik, V.M.; Mashneva, N.I.; Kupriyanova, V.M.

    1986-01-01

    The experiments with white non-inbred mice showed that combined chronic exposure of the animals, preexposed to 90 Sr to ethanol and caused more manifested changes in non-specific humoral immunity (bactericidal properties of blood serum) and in immunologic indices (autoantibodies, immune complexes) than chronic administration of the radionuclide alone. The obtained data proved the possibility of summation and potentiation of the effects of internal irradiation, alcohol and smoking

  12. Transforming Normal Programs by Replacement

    NARCIS (Netherlands)

    Bossi, Annalisa; Pettorossi, A.; Cocco, Nicoletta; Etalle, Sandro

    1992-01-01

    The replacement transformation operation, already defined in [28], is studied wrt normal programs. We give applicability conditions able to ensure the correctness of the operation wrt Fitting's and Kunen's semantics. We show how replacement can mimic other transformation operations such as thinning,

  13. Minimally invasive aortic valve replacement

    DEFF Research Database (Denmark)

    Foghsgaard, Signe; Schmidt, Thomas Andersen; Kjaergard, Henrik K

    2009-01-01

    In this descriptive prospective study, we evaluate the outcomes of surgery in 98 patients who were scheduled to undergo minimally invasive aortic valve replacement. These patients were compared with a group of 50 patients who underwent scheduled aortic valve replacement through a full sternotomy...... operations were completed as mini-sternotomies, 4 died later of noncardiac causes. The aortic cross-clamp and perfusion times were significantly different across all groups (P replacement...... is an excellent operation in selected patients, but its true advantages over conventional aortic valve replacement (other than a smaller scar) await evaluation by means of randomized clinical trial. The "extended mini-aortic valve replacement" operation, on the other hand, is a risky procedure that should...

  14. Transdermal testosterone replacement therapy in men

    Science.gov (United States)

    Ullah, M Iftekhar; Riche, Daniel M; Koch, Christian A

    2014-01-01

    Androgen deficiency syndrome in men is a frequently diagnosed condition associated with clinical symptoms including fatigue, decreased libido, erectile dysfunction, and metabolic syndrome. Serum testosterone concentrations decline steadily with age. The prevalence of androgen deficiency syndrome in men varies depending on the age group, known and unknown comorbidities, and the respective study group. Reported prevalence rates may be underestimated, as not every man with symptoms of androgen deficiency seeks treatment. Additionally, men reporting symptoms of androgen deficiency may not be correctly diagnosed due to the vagueness of the symptom quality. The treatment of androgen deficiency syndrome or male hypogonadism may sometimes be difficult due to various reasons. There is no consensus as to when to start treating a respective man or with regards to the best treatment option for an individual patient. There is also lack of familiarity with treatment options among general practitioners. The formulations currently available on the market are generally expensive and dose adjustment protocols for each differ. All these factors add to the complexity of testosterone replacement therapy. In this article we will discuss the general indications of transdermal testosterone replacement therapy, available formulations, dosage, application sites, and recommended titration schedule. PMID:24470750

  15. Review of SR 97 performance assessment

    International Nuclear Information System (INIS)

    Glynn, P.D.

    2000-01-01

    This review has identified many technical problems in the SR 97 performance assessment. The general impression of this reviewer is that SKB has been disingenuous in its performance assessment effort. It has not cited important differences of opinion with its own views. Furthermore, there are many inconsistencies in the SR 97 report that all together leave the impression that there are many more uncertainties in the SR 97 performance assessment than SKB would perhaps care to admit. Additionally, despite SKB's statements to the contrary, many of the analyses conducted for the SR 97 performance assessment can be clearly shown not to have been based on 'conservative' assumptions. Finally, SKB has made little effort to consider possible coupling effects between their different scenarios in SR 97. This is a serious flaw in the SR 97 performance assessment. The comments in this review should not be taken to imply that the KBS-3 nuclear waste disposal method will not be able to meet the safety and radiation protection requirements which SKI and SSI have specified in recent years. Instead, my conclusion is simply that the SR 97 performance assessment of the KBS-3 method would have been more believable had it been based on a forthright and comprehensive discussion of facts, uncertainties and opinions, and on a more conservative choice of assumptions. As it stands, the SR 97 performance assessment is not very credible

  16. Patients Unicondylar Knee Replacement vs. Total Knee Replacement

    OpenAIRE

    Hedra Eskander

    2017-01-01

    The aim of this review article is to analyse the clinical effectiveness of total knee replacement (TKR) compared to unicondylar knee replacement (UKR) on patients. In terms of survival rates, revision rates and postoperative complications. The keywords used were: knee arthroplasty. Nearly three thousand articles were found on 25 August 2016. Of those, only twenty-five were selected and reviewed because they were strictly focused on the topic of this article. Compared with those who have TKR, ...

  17. Thermodynamic Modeling of Sr/TRU Removal

    International Nuclear Information System (INIS)

    Felmy, A.R.

    2000-01-01

    This report summarizes the development and application of a thermodynamic modeling capability designed to treat the Envelope C wastes containing organic complexants. A complete description of the model development is presented. In addition, the model was utilized to help gain insight into the chemical processes responsible for the observed levels of Sr, TRU, Fe, and Cr removal from the diluted feed from tank 241-AN-107 which had been treated with Sr and permanganate. Modeling results are presented for Sr, Nd(III)/Eu(III), Fe, Cr, Mn, and the major electrolyte components of the waste (i.e. NO 3 , NO 2 , F,...). On an overall basis the added Sr is predicted to precipitate as SrCO 3 (c) and the MnO 4 - reduced by the NO 2 - and precipitated as a Mn oxide. These effects result in only minor changes to the bulk electrolyte chemistry, specifically, decreases in NO 2 - and CO 3 2- , and increases in NO 3 - and OH - . All of these predictions are in agreement with the experimental observations. The modeling also indicates that the majority of the Sr, TRU's (or Nd(III)/Eu(III)) analogs, and Fe are tied up with the organic complexants. The Sr and permanganate additions are not predicted to effect these chelate complexes significantly owing to the precipitation of insoluble Mn oxides or SrCO 3 . These insoluble phases maintain low dissolved concentrations of Mn and Sr which do not affect any of the other components tied up with the complexants. It appears that the removal of the Fe and TRU'S during the treatment process is most likely as a result of adsorption or occlusion on/into the Mn oxides or SrCO 3 , not as direct displacement from the complexants into precipitates. Recommendations are made for further studies that are needed to help resolve these issues

  18. Mirror decay of $^{75}$Sr

    CERN Document Server

    Huikari, J; Algora, A; Cederkäll, J; Courtin, S; Dessagne, P; Fraile-Prieto, L M; Franchoo, S; Fynbo, H O U; Huang Wan Xia; Jokinen, A; Knipper, A; Maréchal, F; Miehé, C; Nácher, E; Peräjärvi, K; Poirier, E; Weissman, L; Äystö, J

    2003-01-01

    The beta -decay of /sup 75/Sr to its mirror nucleus /sup 75/Rb was studied at the ISOLDE PSB facility at CERN by means of beta -delayed gamma and proton spectroscopy. The decay Q-value and beta -delayed gamma intensity were measured for the first time. These results, 10.60+or-0.22 MeV and 4.5/sub -0.7//sup +1.9/%, together with accurate measurements of the beta -decay half-life and beta -delayed proton branching ratio yielded the Gamow-Teller strength 0.35+or-0.05 for the mirror transition. Implications of the results on studies of deformation effects and on the path of the rapid proton capture process are discussed. (24 refs).

  19. Neodymium-doped Sr5(PO4)3F and Sr5(VO4)3F

    International Nuclear Information System (INIS)

    Corker, D.L.; Nicholls, J.; Loutts, G.B.

    1995-01-01

    Neodymium-doped Sr 5 (PO 4 ) 3 F [neodymium strontium fluoride phosphate, (Nd,Sr) 5 (PO 4 ) 3 F] and neodymium-doped Sr 5 (VO 4 ) 3 F [neodymium strontium fluoride vanadate, (Nd,Sr) 5 (VO 4 ) 3 F] crystallize in space group P6 3 /m and are isostructural with calcium fluorophosphate, Ca 5 (PO 4 ) 3 F. There are two different Sr sites in Sr 5 (XO 4 ) 3 F, denoted Sr(1) and Sr(2). Using single-crystal X-ray diffraction the two structures were refined to R factors of 2.3 and 2.2%, respectively, showing that Nd is present at both Sr sites in (Sr,Nd) 5 (VO 4 ) 3 F but only at the Sr(2) site in (Sr,Nd) 5 (PO 4 ) 3 F. (orig.)

  20. Zinc in human serum

    International Nuclear Information System (INIS)

    Kiilerich, S.

    1987-01-01

    The zinc ion is essential for the living organism. Many pathological conditions have been described as a consequence of zinc deficiency. As zinc constitutes less than 0.01 per cent of the body weight, it conventionally belongs to the group of trace elements. The method of atomic absorption spectrophotometry is used to measure the concentration of zinc in serum and urine from healthy persons. The assumptions of the method is discussed. The importance of proteinbinding, diet and the diurnal variation of serum zinc concentration is presented. Serum versus plasma zinc concentration is discussed. Reference serum zinc values from 104 normal subjects are given. Zinc in serum is almost entirely bound to proteins. A preliminary model for the estimation of the distribution of zinc between serum albumin and α 2 -macroglobulin is set up. This estimate has been examined by an ultracentrufugation method. The binding of zinc to a α 2 -macroglobulin in normal persons is appoximately 7 per cent, in patients with cirrhosis of the liver of alcoholic origin approximately 6 per cent, in patients with insulin dependent diabetes mellitus approximately 5 per cent, and in patients with chronic renal failure approximately 2 per cent. It is concluded, therefore, that for clinical purposes it is sufficient to use the concentration of total serum zinc corrected for the concentration of serum albumin. (author)

  1. Nuclear reactor fuel replacement system

    International Nuclear Information System (INIS)

    Kayano, Hiroyuki; Joge, Toshio.

    1976-01-01

    Object: To permit the direction in which a fuel replacement unit is moving to be monitored by the operator. Structure: When a fuel replacement unit approaches an intermediate goal position preset in the path of movement, renewal of data display on a goal position indicator is made every time the goal position is changed. With this renewal, the prevailing direction of movement of the fuel replacement unit can be monitored by the operator. When the control of movement is initiated, the co-ordinates of the intermediate goal point A are displayed on a goal position indicator. When the replacement unit reaches point A, the co-ordinates of the next intermediate point B are displayed, and upon reaching point B the co-ordinates of the (last) goal point C are displayed. (Nakamura, S.)

  2. Slab replacement maturity guidelines : [summary].

    Science.gov (United States)

    2014-04-01

    Concrete sets in hours at moderate temperatures, : but the bonds that make concrete strong continue : to mature over days to years. However, for : replacement concrete slabs on highways, it is : crucial that concrete develop enough strength : within ...

  3. Prolonged Intermittent Renal Replacement Therapy.

    Science.gov (United States)

    Edrees, Fahad; Li, Tingting; Vijayan, Anitha

    2016-05-01

    Prolonged intermittent renal replacement therapy (PIRRT) is becoming an increasingly popular alternative to continuous renal replacement therapy in critically ill patients with acute kidney injury. There are significant practice variations in the provision of PIRRT across institutions, with respect to prescription, technology, and delivery of therapy. Clinical trials have generally demonstrated that PIRRT is non-inferior to continuous renal replacement therapy regarding patient outcomes. PIRRT offers cost-effective renal replacement therapy along with other advantages such as early patient mobilization and decreased nursing time. However, due to lack of standardization of the procedure, PIRRT still poses significant challenges, especially pertaining to appropriate drug dosing. Future guidelines and clinical trials should work toward developing consensus definitions for PIRRT and ensure optimal delivery of therapy. Copyright © 2016 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

  4. Replacement of sub-systems

    International Nuclear Information System (INIS)

    Rosen, S.E.

    1992-01-01

    This paper describes a number of quality aspects related to replacement of important systems or components in a nuclear power station. Reference is given to the steam generator replacement and power uprating performed at Ringhals 2 in Sweden in 1989. Since quality is a wide concept there has been put special emphasis in this paper to the important aspects that traditionally are not connected to quality. (author) 1 fig

  5. Feeder replacement tooling and processes

    International Nuclear Information System (INIS)

    Mallozzi, R.; Goslin, R.; Pink, D.; Askari, A.

    2008-01-01

    Primary heat transport system feeder integrity has become a concern at some CANDU nuclear plants as a result of thinning caused by flow accelerated corrosion (FAC). Feeder inspections are indicating that life-limiting wall thinning can occur in the region between the Grayloc hub weld and second elbow of some outlet feeders. In some cases it has become necessary to replace thinned sections of affected feeders to restore feeder integrity to planned end of life. Atomic Energy of Canada Limited (AECL) and Babcock and Wilcox Canada Ltd. (B and W) have developed a new capability for replacement of single feeders at any location on the reactor face without impacting or interrupting operation of neighbouring feeders. This new capability consists of deploying trained crews with specialized tools and procedures for feeder replacements during planned outages. As may be expected, performing single feeder replacement in the congested working environment of an operational CANDU reactor face involves overcoming many challenges with respect to access to feeders, available clearances for tooling, and tooling operation and performance. This paper describes some of the challenges encountered during single feeder replacements and actions being taken by AECL and B and W to promote continuous improvement of feeder replacement tooling and processes and ensure well-executed outages. (author)

  6. Autoradiography of 90Sr in developing rats

    International Nuclear Information System (INIS)

    Olsen, I.; Jonsen, J.

    1979-01-01

    The distribution patterns of 90 Sr in five littermate, 8-day-old Wistar rats were studied by whole body autoradiography. Rats were killed 15 min, 1, 4, 24, and 72 h after a single intraperitoneal injection of the isotope. Immediately after administration, 90 Sr was distributed throughout most of the soft tissues of the body. The soft tissue deposits had practically disappeared after 4 h. In the hard tissues of the body 90 Sr accumulated up to 24-72 h. Fifteen minutes after injection the uptake of 90 Sr in the enamel of the teeth was highest in the occlusal and incisal regions. 90 Sr gradually accumulated throughout the enamel and after 72 h its distribution in this layer was fairly uniform. Immediately after injection a narrow zone of radioactivity appeared in the dentin near the pulp. This zone broadened with time towards the dentinoenamel junction and included the intire dentin layer 72 h after injection. Initially, the uptake of 90 Sr was higher in the dentin than in the enamel, particularly in the cervical areas of the crown. This difference became less apparent with time. There was good correlation between the uptake in the teeth and bones, supporting the use of teeth as indicators of the 90 Sr body burden. (author)

  7. PREGNANCY LOSS IN THE F344 RAT CAUSED BY BROMODICHLOROMETHANE: EFFECTS ON SERUM LUTEINIZING HORMONE LEVELS

    Science.gov (United States)

    PREGNANCY LOSS IN THE F344 RAT CAUSED BY BROMODICHLOROMETHANE: EFFECTS ON SERUM LUTEINIZING HORMONE LEVELS Bielmeier1, S.R., D.S. Best2, and M.G. Narotsky2; 1University of North Carolina at Chapel Hill, Curriculum in Toxicology, 2Reproductive Toxicology Division, U.S. Enviro...

  8. Maxdose-SR and popdose-SR routine release atmospheric dose models used at SRS

    Energy Technology Data Exchange (ETDEWEB)

    Jannik, G. T. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Trimor, P. P. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2017-07-28

    MAXDOSE-SR and POPDOSE-SR are used to calculate dose to the offsite Reference Person and to the surrounding Savannah River Site (SRS) population respectively following routine releases of atmospheric radioactivity. These models are currently accessed through the Dose Model Version 2014 graphical user interface (GUI). MAXDOSE-SR and POPDOSE-SR are personal computer (PC) versions of MAXIGASP and POPGASP, which both resided on the SRS IBM Mainframe. These two codes follow U.S. Nuclear Regulatory Commission (USNRC) Regulatory Guides 1.109 and 1.111 (1977a, 1977b). The basis for MAXDOSE-SR and POPDOSE-SR are USNRC developed codes XOQDOQ (Sagendorf et. al 1982) and GASPAR (Eckerman et. al 1980). Both of these codes have previously been verified for use at SRS (Simpkins 1999 and 2000). The revisions incorporated into MAXDOSE-SR and POPDOSE-SR Version 2014 (hereafter referred to as MAXDOSE-SR and POPDOSE-SR unless otherwise noted) were made per Computer Program Modification Tracker (CPMT) number Q-CMT-A-00016 (Appendix D). Version 2014 was verified for use at SRS in Dixon (2014).

  9. Casca de algodão em substituição parcial à silagem de capim-elefante para novilhos. 2. Parâmetros ruminais e séricos, produção microbiana e excreção urinária de compostos nitrogenados Partial replacement of elephantgrass silage with cottonseed hulls. 2. Ruminal and serum metabolites, microbial protein synthesis, and urinary excretion of nitrogenous compounds in steers

    Directory of Open Access Journals (Sweden)

    Mario Luiz Chizzotti

    2005-12-01

    Full Text Available Quatro novilhos holandeses fistulados no rúmen, com peso médio de 259 kg, foram distribuídos em um quadrado latino 4 x 4 para se avaliar o efeito dos níveis de casca de algodão na dieta de novilhos sobre a concentração de nitrogênio uréico no soro (NUS e de amônia no rúmen, o pH ruminal, a excreção urinária de uréia e derivados de purinas e a produção de proteína microbiana estimada pelo método das bases purinas omasais e da excreção de derivados de purinas na urina. As dietas experimentais continham na base da matéria seca: 0, 10, 20 e 30% de casca de algodão peletizada, em substituição à silagem de capim-elefante, sendo a dieta total constituída de 60% de volumoso. Não houve efeito dos diferentes tratamentos sobre o pH e as concentrações de amônia no rúmen. A concentração de NUS e a excreção de uréia (em mg/kgPV diminuíram, enquanto a excreção de derivados de purinas na urina e a síntese de proteína microbiana no rúmen aumentaram linearmente com a inclusão da casca de algodão nas dietas. A estimativa da síntese de proteína microbiana não diferiu entre as metodologias das bases purínicas omasais e dos derivados de purina na urina. A casca de algodão mostrou-se um bom volumoso alternativo, podendo ser fornecida até o nível de 30% na MS total na dieta de novilhos de origem leiteira.Four ruminally cannulated Holstein steers averaging 259 kg of body weight were assigned to a 4x4 Latin square to study the effects of replacing elephantgrass silage with cottonseed hulls on serum urea nitrogen (SUN, ruminal metabolism, urinary excretion of nitrogenous compounds, and microbial protein synthesis measured by omasal purine bases or by urinary excretion of purine derivatives. Treatments (60% of forage contained on DM basis: 0, 10, 20 or 30% of cottonseed hulls that partially replaced elephantgrass silage in the diet. No significant differences in ruminal pH and concentration of ruminal ammonia were

  10. Erythrocyte indices and serum biochemical constituents of broiler ...

    African Journals Online (AJOL)

    One hundred and twenty (120) four weeks old Ross breed broiler finisher birds were used to study the effect of feeding maggot meal as a replacement for fish meal on erythrocyte indices and serum biochemical constituents. The birds were divided into 5 treatment groups identified as T1, T2, T3 , T4 and T5 with 24 birds per ...

  11. Report on nuclear energy in SR Slovenia

    International Nuclear Information System (INIS)

    1987-01-01

    Currently Yugoslavia has one 632 MWe nuclear power plant (NPP) of PWR design, located at Krsko in the Socialist Republic (SR) of Slovenia. Krsko NPP, which is a two-loop plant, started power operation in 1981. In general, reactor safety activities in the SR of Slovenia are mostly related to upgrading the safety of our Krsko NPP and to developing capabilities for use in future units. This report presents the nuclear safety related legislation and organization of the corresponding regulatory body, and the activities related to nuclear safety of the participating organizations in the SR of Slovenia in 1987.

  12. Prioritization methodology for chemical replacement

    Science.gov (United States)

    Cruit, Wendy; Goldberg, Ben; Schutzenhofer, Scott

    1995-01-01

    Since United States of America federal legislation has required ozone depleting chemicals (class 1 & 2) to be banned from production, The National Aeronautics and Space Administration (NASA) and industry have been required to find other chemicals and methods to replace these target chemicals. This project was initiated as a development of a prioritization methodology suitable for assessing and ranking existing processes for replacement 'urgency.' The methodology was produced in the form of a workbook (NASA Technical Paper 3421). The final workbook contains two tools, one for evaluation and one for prioritization. The two tools are interconnected in that they were developed from one central theme - chemical replacement due to imposed laws and regulations. This workbook provides matrices, detailed explanations of how to use them, and a detailed methodology for prioritization of replacement technology. The main objective is to provide a GUIDELINE to help direct the research for replacement technology. The approach for prioritization called for a system which would result in a numerical rating for the chemicals and processes being assessed. A Quality Function Deployment (QFD) technique was used in order to determine numerical values which would correspond to the concerns raised and their respective importance to the process. This workbook defines the approach and the application of the QFD matrix. This technique: (1) provides a standard database for technology that can be easily reviewed, and (2) provides a standard format for information when requesting resources for further research for chemical replacement technology. Originally, this workbook was to be used for Class 1 and Class 2 chemicals, but it was specifically designed to be flexible enough to be used for any chemical used in a process (if the chemical and/or process needs to be replaced). The methodology consists of comparison matrices (and the smaller comparison components) which allow replacement technology

  13. Optimization of station battery replacement

    International Nuclear Information System (INIS)

    Jancauskas, J.R.; Shook, D.A.

    1994-01-01

    During a loss of ac power at a nuclear generating station (including diesel generators), batteries provide the source of power which is required to operate safety-related components. Because traditional lead-acid batteries have a qualified life of 20 years, the batteries must be replaced a minimum of once during a station's lifetime, twice if license extension is pursued, and more often depending on actual in-service dates and the results of surveillance tests. Replacement of batteries often occurs prior to 20 years as a result of systems changes caused by factors such as Station Blackout Regulations, control system upgrades, incremental load growth, and changes in the operating times of existing equipment. Many of these replacement decisions are based on the predictive capabilities of manual design basis calculations. The inherent conservatism of manual calculations may result in battery replacements occurring before actually required. Computerized analysis of batteries can aid in optimizing the timing of replacements as well as in interpreting service test data. Computerized analysis also provides large benefits in maintaining the as-configured load profile and corresponding design margins, while also providing the capability of quickly analyze proposed modifications and response to internal and external audits

  14. 89Sr and 90Sr in atmospheric precipitations in May 1986 in Bucharest-Magurele area

    International Nuclear Information System (INIS)

    Paunescu, N.; Vata, I.

    1987-08-01

    Sr-89 and Sr-90 were determined in the fallout of May 1986. The maximum values of 335 Bq/(m 2 * 6 hours) and 110 Bq/(m 2 * 6 hours) were observed at May 2 and 5. Throughout May 1986 a quantity of 860 Bq/m 2 of Sr-90 deposited from the fallout in the Bucharest -Magurele area was determined. (authors)

  15. Results of field studies on 90SR and stable SR soil-to-plant transfer

    International Nuclear Information System (INIS)

    Gerzabek, M.H.; Artner, C.; Horak, O.; Mueck, K.

    1992-01-01

    In 1987 and 1988 at 35 sites plants ready to harvest and the corresponding soils (0 - 20 cm) were collected for 90 Sr and stable strontium analyses. Sample preparation and measurement led to a detection limit of 0.008 Bq 90 Sr kg -1 . The 90 Sr-contamination of Austrian soils ranged from 396 to 1998 Bq m -2 . Known from literature the contribution of the Chernobyl fallout amounted to app. 25 % of the total contamination. Stable strontium contents of the soils were between 6 and 62.5 mg kg -1 . Bariumtriethanolamine extracted 17.7 to 62.3 % of the total stable Sr in soil. 90 Sr-concentrations in cereal grains ranged from 0.03 to 0.67 Bq kg -1 (fresh wight) for maize and barley, respectively. The values for other foodstuff were between 0.15 (white cabbage) and 0.91 Bq kg -1 (spinach). Stable strontium contents were between 0.079 mg kg -1 (maize) and 72.5 mg kg -1 (celery shoot). The following mean 90 Sr soil-to-plant transfer factors for cereal grains were obtained: 0.010 (maize), 0.097 (rye), 0.049 (wheat), 0.095 (barley). Transfer factors for straw were up to 50 times higher (maize). The transfer of 90 Sr into vegetables and potatoes reached the same order of magnitude compared to the cereals. In all cases soil-to-plant transfer of stable Sr was clearly lower up to 60 % of the respective values for 90 Sr. Thus natural stable strontium is less plant available than 90 Sr. The influence of soil parameters on the 90 Sr transfer into plants was examinated by correlation analyses. Increasing exchangeable calcium contents of the soils resulted in a significant reduction of Sr soil-to-barley straw transfer. (authors)

  16. Addition to the analysis of the Sr VI and Sr VII spectra

    International Nuclear Information System (INIS)

    Wyart, J.F.

    1989-01-01

    Fifty-six lines of multicharged strontium are measured with an improved wavelength accuracy, or interpreted for the first time. They are 4p-4s, 4p-5s and 4p-4d transitions in Sr VII and 4p-5s transitions in Sr VI. The revision of the singlet-triplet connection in Sr VII is supported by theoretical survey of the ground configuration in Ge-like ions. (orig.)

  17. 82Sr--82Rb radioisotope generator

    International Nuclear Information System (INIS)

    Grant, P.M.; Erdal, B.R.; O'Brien, H.A.

    1976-01-01

    An improved 82 Sr- 82 Rb radioisotope generator system, based upon the complexing ion exchange resin Chelex-100, has been developed. Columns of this material can be easily and rapidly milked, and the Rb-Sr separation factor for a fresh generator was found to be greater than 10 7 . Approximately 80 percent of the 82 Rb present was delivered in a 15-ml volume of aqueous 0.2 M NH 4 Cl solution. After more than 6 liters of eluant had been put through the generator, the Rb-Sr separation factor was still observed to be greater than 10 5 , and no unusual strontium breakthrough behavior was seen in the system over nearly three 82 Sr half lives. 2 claims, no drawings

  18. Large room-temperature tunneling anisotropic magnetoresistance and electroresistance in single ferromagnet/Nb:SrTiO3 Schottky devices.

    Science.gov (United States)

    Kamerbeek, Alexander M; Ruiter, Roald; Banerjee, Tamalika

    2018-01-22

    There is a large effort in research and development to realize electronic devices capable of storing information in new ways - for instance devices which simultaneously exhibit electro and magnetoresistance. However it remains a challenge to create devices in which both effects coexist. In this work we show that the well-known electroresistance in noble metal-Nb:SrTiO 3 Schottky junctions can be augmented by a magnetoresistance effect in the same junction. This is realized by replacing the noble metal electrode with ferromagnetic Co. This magnetoresistance manifests as a room temperature tunneling anisotropic magnetoresistance (TAMR). The maximum room temperature TAMR (1.6%) is significantly larger and robuster with bias than observed earlier, not using Nb:SrTiO 3 . In a different set of devices, a thin amorphous AlO x interlayer inserted between Co and Nb:SrTiO 3 , reduces the TAMR by more than 2 orders of magnitude. This points to the importance of intimate contact between the Co and Nb:SrTiO 3 for the TAMR effect. This is explained by electric field enhanced spin-orbit coupling of the interfacial Co layer in contact with Nb:SrTiO 3 . We propose that the large TAMR likely has its origin in the 3d orbital derived conduction band and large relative permittivity of Nb:SrTiO 3 and discuss ways to further enhance the TAMR.

  19. CHARACTERIZATION OF THE PARTIALLY PURIFIED PLANTARCIN SR18 PRODUCED BY LACTOBACILLUS PLANTARUM SR18

    Directory of Open Access Journals (Sweden)

    Wagih El-Shouny

    2013-04-01

    Full Text Available The bacteriocin bound to the cells and that secreted into the culture filtrate of Lactobacillus plantarum SR18 were precipitated by 75% ammomium sulphate, dialysed and further purified by Gel filtration on Sephadex G-100. Bacteriocins were purified from proteins bound to the cell of L. plantarum SR18 (plantarcin SR18 a and culture filtrate proteins (plantarcin SR18 b, respectively. The SDS-PAGE of partially purified Plantarcin SR18a showed a molecular weight of 3.5 KDa. While, plantarcin SR18 b had a molecular weight of 10.3 KDa. The antibacterial activity of the tested plantarcin SR18 preparations suffered no measurable loss after 45 min at 80ºC. Whereas, At 100ºC, significant decrease in the activity of bacteriocin preparations (60- 80 % took place by the end of 45 min. At pH ranged from 5-8, the activity of the plantarcin SR18 preparations suffered no measurable loss. Dissociating agents significantly affected the bacteriocin activity. Thus, tween 80 and mercaptoethanol increased the activity of bacteriocin preparations to 1.2-1.4 fold. Sodium dodecyl sulphate (SDS increased the activity of the tested bacteriocin preparations by about 20%.The lowest residual activity (60% was recorded after treatment with Triton X100 for 45 min. Protease completely inhibited the activities of all forms of plantarcin SR18 after 45 min at 37ºC.

  20. Metastable honeycomb SrTiO_3/SrIrO_3 heterostructures

    International Nuclear Information System (INIS)

    Anderson, T. J.; Ryu, S.; Podkaminer, J. P.; Ma, Y.; Eom, C. B.; Zhou, H.; Xie, L.; Irwin, J.; Rzchowski, M. S.; Pan, X. Q.

    2016-01-01

    Recent theory predictions of exotic band topologies in (111) honeycomb perovskite SrIrO_3 layers sandwiched between SrTiO_3 have garnered much attention in the condensed matter physics and materials communities. However, perovskite SrIrO_3 film growth in the (111) direction remains unreported, as efforts to synthesize pure SrIrO_3 on (111) perovskite substrates have yielded films with monoclinic symmetry rather than the perovskite structure required by theory predictions. In this study, we report the synthesis of ultra-thin metastable perovskite SrIrO_3 films capped with SrTiO_3 grown on (111) SrTiO_3 substrates by pulsed laser deposition. The atomic structure of the ultra-thin films was examined with scanning transmission electron microscopy (STEM), which suggests a perovskite layering distinct from the bulk SrIrO_3 monoclinic phase. In-plane 3-fold symmetry for the entire heterostructure was confirmed using synchrotron surface X-ray diffraction to measure symmetry equivalent crystal truncation rods. Our findings demonstrate the ability to stabilize (111) honeycomb perovskite SrIrO_3, which provides an experimental avenue to probe the phenomena predicted for this material system.

  1. Replacement research reactor for Australia

    International Nuclear Information System (INIS)

    Miller, Ross

    1998-01-01

    In 1992, the Australian Government commissioned a review into the need for a replacement research reactor. That review concluded that in about years, if certain conditions were met, the Government could make a decision in favour of a replacement reactor. A major milestone was achieved when, on 3 September 1997, the Australian Government announced the construction of a replacement research reactor at the site of Australia's existing research reactor HIFAR, subject to the satisfactory outcome of an environmental assessment process. The reactor will be have the dual purpose of providing a first class facility for neutron beam research as well as providing irradiation facilities for both medical isotope production and commercial irradiations. The project is scheduled for completion before the end of 2005. (author)

  2. BiCaSrCuO superconductors

    International Nuclear Information System (INIS)

    Polvi, V.M.; Niemi, K.J.

    1989-01-01

    BiCaSrCuO and BiPbCaSrCuO powders have been synthesized. Different research methods (SEM,EDS,XRF,SRD,DTA) have been used to characterize the bulk specimen and wires. Resistance and current density measured as a function of temperature are reported. The ceramic products contained several phases. Lead containing specimen gave the best results and the synthesis was easily reproducible

  3. Joint replacement in Zambia: A review of Hip & Knee Replacement ...

    African Journals Online (AJOL)

    Methods: Data captured by the different variables entered into the Joint Register covering the pre-op, intra-op and post-op period of all total hip and knee replacement surgery done at the ZIOH from 1998 to 2010 was entered into a spreadsheet after verification with individual patient medical records. This was then imported ...

  4. HST Replacement Battery Initial Performance

    Science.gov (United States)

    Krol, Stan; Waldo, Greg; Hollandsworth, Roger

    2009-01-01

    The Hubble Space Telescope (HST) original Nickel-Hydrogen (NiH2) batteries were replaced during the Servicing Mission 4 (SM4) after 19 years and one month on orbit.The purpose of this presentation is to highlight the findings from the assessment of the initial sm4 replacement battery performance. The batteries are described, the 0 C capacity is reviewed, descriptions, charts and tables reviewing the State Of Charge (SOC) Performance, the Battery Voltage Performance, the battery impedance, the minimum voltage performance, the thermal performance, the battery current, and the battery system recharge ratio,

  5. Insurance for replacement power costs

    International Nuclear Information System (INIS)

    Cleaver, A.

    1980-01-01

    Although careful consideration is given to insurance against physical damage to plant and equipment, little thought is given to the costs that will be incurred in replacing the power that is lost while a relatively efficient system is out of action. The results of an investigation carried out for a generating authority with an installed capacity of about 3000 MW is given. Replacement power costs for different cases of severity of damage range from Pound1.17m per month for damage to central services taking out all four units. (author)

  6. Replacing fuel alignment in Germany

    International Nuclear Information System (INIS)

    Poetz, F.; Kalthoff, W.

    1991-01-01

    Up to the end of 1989 varying numbers of broken fuel alignment pins were detected in several German PWRs (80 broken pins in all). The distribution of these broken pins over the core cross-section was more or less random. The problem was due to the stress corrosion cracking of the pin material and was restricted to individual pins. It was concluded that all fuel alignment pins made of Inconel X-750 should be replaced. The development of a new pin, more resistant to intergranular stress corrosion, and the replacement technique are outlined. (author)

  7. Modification of Sr on 4004 Aluminum Alloy

    Science.gov (United States)

    Guo, Erjun; Cao, Guojian; Feng, Yicheng; Wang, Liping; Wang, Guojun; Lv, Xinyu

    2013-05-01

    As a brazing foil, 4004 Al alloy has good welding performance. However, the high Si content decreases the plasticity of the alloy. To improve the plasticity of 4004 Al alloy and subsequently improve the productivity of 4004 Al foil or 434 composite foil, 4004 Al alloy was modified by Al-10%Sr master alloy. Modification effects of an additional amount of Sr, modification temperature, and holding time on 4004 aluminum alloy were studied by orthogonal design. The results showed that the greatest impact parameter of 4004 aluminum alloy modification was the additional amount of Sr, followed by holding time and modification temperature. The optimum modification parameters obtained by orthogonal design were as follows: Sr addition of 0.04%, holding time of 60 min, and modification temperature of 760°C. The effect of Sr addition on modification was analyzed in detail based on orthogonal results. With increasing of Sr addition, elongation of 4004 alloy increased at first, and decreased after reaching the maximum value.

  8. Effect of renal replacement therapy on retinol-binding protein 4 isoforms

    DEFF Research Database (Denmark)

    Frey, Simone K; Henze, Andrea; Nagl, Britta

    2009-01-01

    Retinol-binding protein 4 (RBP4) levels are elevated in the serum of patients with kidney dysfunction. We recently showed that RBP4 isoforms including apo-RBP4 (RBP4 not bound to retinol) and RBP4 truncated at the C-terminus (RBP4-L, RBP4-LL) are increased in the serum of patients with kidney dis...... diseases but not in serum of patients with various liver diseases. The aim of this study was to investigate the effect of renal replacement therapy on RBP4 isoforms....

  9. Absolute measurement of 85Sr

    International Nuclear Information System (INIS)

    Miyahara, Hiroshi; Watanabe, Tamaki

    1978-01-01

    An extension of 4πe.x-γ coincidence technique is described to measure the absolute disintegration rate of 85 Sr. This nuclide shows electron capture-gamma decay, and 514keV level of 85 Rb is a meta-stable state with half life of 0.958 μsec. Therefore, the conventional 4 πe.x-γ coincidence technique with about 1 μsec of resolution time can not be applied to this nuclide. To measure the absolute disintegration rate of this, the delayed 4 πe.x-γ coincidence technique with two different resolution time has been used. The disintegration rate was determined from four counting rates of electron-x ray, gamma ray and two coincidences, and the true disintegration rate could be obtained by extraporation of the electron-x ray detection efficiency to 1. Two resolution time appearing in the calculation formulas were determined from the chance coincidence between electron-x ray and delayed gamma ray signals. When the coincidence countings with three different resolution time were carried out by one coincidence circuit, the results calculated from all combinations did not agree each other. However, when the two coincidence circuits of the same type were used to fix the resolution time, a good coincidence absorption function was obtained and the disintegration rate was determined with accuracy of +- 0.5%. To evaluate the validity of the results the disintegration rates were measured by two NaI (Tl) scintillation detectors whose gamma-ray detection efficiency was previously determined and both results were agreed within accuracy of +- 0.5%. This method can be applied with nearly same accuracy for the beta-gamma decay nuclide possessing a meta-stable state of the half life below about 10 μsec. (auth.)

  10. Real-time {sup 90}Sr Counter

    Energy Technology Data Exchange (ETDEWEB)

    Kaneko, Naomi; Kawai, Hideyuki; Kodama, Satoshi; Kobayashi, Atsushi; Tabata, Makoto; Ito, Hiroshi [Graduate School of Science, Chiba University, Chiba, (Japan); Han, Soorim [Graduate School of Science, Chiba University, Chiba, (Japan); National Institute of Radiological Science, Chiba, (Japan)

    2015-07-01

    Radioisotopes have been emitted around Japan due to a nuclear accident at the Fukushima Daiichi nuclear power station in March 2011. A problem is the contaminated water including the atomic nucleus which relatively has a long half- life time and soluble such as {sup 90}Sr, {sup 137}Cs. Internal exposures by {sup 90}Sr are more dangerous than {sup 137}Cs's because Sr has effective half-life time of 18 years and property of accumulation in a born. We have developed real-time {sup 90}Sr counter which is sensitive beta-ray of maximum kinematic energy of 2.28 MeV from {sup 90}Sr and insensitive of beta-ray of maximum kinematic energy of 1.17 MeV and gamma-ray from {sup 90}Sr by Cherenkov detection. This counter composes of Cerenkov counter, trigger scintillation counter and veto counter. Silica aerogel for Cherenkov counter can obtain refractive index between 1.017 and 1.049 easily. And wavelength shifting fiber (WLSF) is used as a light guide for extending effective area and producing lower cost. A mechanism of the identification of {sup 90}Sr is explained in following. In case of {sup 90}Sr, when the trigger counter reacts on the beta-ray from {sup 90}Sr, aerogel emits the Cherenkov light and WLSF reacts and read the Cherenkov light. On the other hand, in case of {sup 137}Cs, the trigger counter reacts on the beta-ray, aerogel stops the beta- ray and Cherenkov light is not emitted. Therefore, aerogel has a function as a radiator and shielding material. the gamma-ray is not reacted on the lower density detector. Cosmic rays would be also reacted by the veto counter. A prototype counter whose the effective area is 30 cm x 10 cm was obtained (2.0±1.2){sup 3} of mis-identification as {sup 137}Cs/{sup 90}Sr. Detection limit in the surface contamination inspection depends on measurement time and effective area mainly. The sensitivity of wide range, 10{sup -2} - 10{sup 4} Bq/cm{sup 2}, is obtained by adjustment of detection level in circuit of this counter. A lower

  11. Testing of Replacement Bag Material

    International Nuclear Information System (INIS)

    Laurinat, J.E.

    1998-01-01

    Recently, the FB-Line bagout material was changed to simplify the processing of sand, slag, and crucible.The results of the strength tests and the outgassing measurements and calculations demonstrate that the proposed replacement nylon bag materials (HRMP and orange anti-static material) are acceptable substitutes for LDPE and the original nylon with respect to mechanical properties

  12. Electrocatalysts Prepared by Galvanic Replacement

    Directory of Open Access Journals (Sweden)

    Athanasios Papaderakis

    2017-03-01

    Full Text Available Galvanic replacement is the spontaneous replacement of surface layers of a metal, M, by a more noble metal, Mnoble, when the former is treated with a solution containing the latter in ionic form, according to the general replacement reaction: nM + mMnoblen+ → nMm+ + mMnoble. The reaction is driven by the difference in the equilibrium potential of the two metal/metal ion redox couples and, to avoid parasitic cathodic processes such as oxygen reduction and (in some cases hydrogen evolution too, both oxygen levels and the pH must be optimized. The resulting bimetallic material can in principle have a Mnoble-rich shell and M-rich core (denoted as Mnoble(M leading to a possible decrease in noble metal loading and the modification of its properties by the underlying metal M. This paper reviews a number of bimetallic or ternary electrocatalytic materials prepared by galvanic replacement for fuel cell, electrolysis and electrosynthesis reactions. These include oxygen reduction, methanol, formic acid and ethanol oxidation, hydrogen evolution and oxidation, oxygen evolution, borohydride oxidation, and halide reduction. Methods for depositing the precursor metal M on the support material (electrodeposition, electroless deposition, photodeposition as well as the various options for the support are also reviewed.

  13. Testosterone replacement in male hypogonadism

    OpenAIRE

    Kalra, Sanjay; Agrawal, Navneet; Kumar, Satish; Sharma, Amit

    2010-01-01

    Sanjay Kalra1, Navneet Agrawal2, Satish Kumar3, Amit Sharma11Department of Endocrinology, Bharti Hospital, Karnal, India; 2Dept of Medicine, GR Medical College, Gwalior, India; 3Clinical Research, EXCEL Life Sciences, NOIDA, IndiaAbstract: This article contains a review of the clinical aspects of testosterone replacement in androgen deficiency of the aging male.Keywords: testosterone, supplementation, hypogonadism, ADAM

  14. Electronic parameters of Sr2M2O7 (M = V, Nb, Ta) and Sr-O chemical bonding

    DEFF Research Database (Denmark)

    Atuchin, Victor V.; Grivel, Jean-Claude; Zhang, Zhaoming

    2010-01-01

    XPS measurements were carried out on Sr2Nb2O7 and Sr2Ta2O7 powder samples, which were synthesized using standard solid state method. The binding energy differences between the O 1s and cation core level, Δ(O-Sr) = BE(O 1s) - BE(Sr 3d5/2), was used to characterize the valence electron transfer...... on the formation of the Sr-O bonds. The chemical bonding effects were considered on the basis of our XPS results for Sr2Nb2O7 and Sr2Ta2O7 and the previously published structural and XPS data for other Sr-oxide compounds. A new empirical relationship between Δ(O-Sr) and L(Sr-O) was obtained. Possible applications...

  15. Development of 90Sr-90Y generators

    International Nuclear Information System (INIS)

    Barrio, Graciela

    2007-01-01

    Yttrium-90 is a radioisotope of great interest in the field of Nuclear Medicine. It is considered one of the most important and most used radionuclides for radioimmunotherapeutical applications, especially promising for the treatment of certain types of cancer. Another important application of 90 Y is radio synovectomy. This radionuclide has a half-life of 64 hours, emits long range beta particles (maximum energy of 2.3 MeV) and decays, without intermediate nuclides, to a stable daughter. 90 Y may be obtained carrier-free, generated by the decay of its parent 90 Sr (half-life=28 years). 90 Sr is a product from uranium fission, and due to its long half-life, can be indefinitely used, which is certainly advantageous. It is present in great amounts, and needs to be processed and purified in order to be used as raw material for the generators. Generators of 90 Sr- 90 Y may thus be used during various months, due to 90 Sr long half-life. Several methods for the separation of 90 Y from 90 Sr by solvent extraction and ion exchange have been reported in literature. Thanks to its simplicity, ion exchange techniques have been more commonly used for this generator system. The main objective of this work was to develop a methodology for the preparation of 90 Sr- 90 Y generators, using cationic exchange resins. In such method, 90 Sr is strongly adsorbed in the resin and 90 Y is eluted by a 0.003 M EDTA solution. According to the quality control carried out, results showed that elution yields are greater than 65%, thus confirming the efficiency of the separation method used.

  16. Short communication: Absorption of protein and immunoglobulin g in calves fed a colostrum replacer.

    Science.gov (United States)

    Smith, G W; Foster, D M

    2007-06-01

    A well-managed colostrum program on farms is the most important step in reducing disease in neonatal calves. In the last few years, colostrum replacers have increased in popularity and are designed to be an alternative to colostrum on farms that have poor colostrum quality, limited colostrum reserves, or to break the cycle of transmission for certain infectious diseases. However, it is important to make sure these products are effective and are capable of providing adequate serum immunoglobulin concentrations. The objective of this study was to evaluate the efficacy of a commercially available colostrum replacer product in dairy calves. Holstein calves from a single dairy were randomly assigned to 1 of 3 groups at birth. Group 1 (n = 21) calves were given 4 quarts of colostrum via esophageal feeder within 3 h of birth and served as the control group for this study. Group 2 (n = 21) received 2 packages of a colostrum replacer product, and group 3 (n = 21) received 3 packages of the colostrum replacer product within 3 h of birth. Blood samples from all calves were collected 24 h after colostrum administration and analyzed for serum total protein and IgG concentrations. Calves fed fresh colostrum had significantly higher serum total protein levels and IgG concentrations compared with calves fed the colostrum replacer product. Calves fed the colostrum replacer also had a significantly higher percentage of calves with failure of passive transfer (serum IgG <1,000 mg/dL). The colostrum replacer product evaluated in this study failed to routinely provide adequate IgG concentrations when fed according to label directions.

  17. Construction of the seawater 87Sr/86Sr curve for the Cenozoic and Cretaceous: supporting data

    International Nuclear Information System (INIS)

    Koepnick, R.B.; Burke, W.H.; Denison, R.E.; Hetherington, E.A.; Nelson, H.F.; Otto, J.B.; Waite, L.E.

    1985-01-01

    We present the data used to construct the Cenozoic and Cretaceous portion of the Phanerozoic curve of seawater 87 Sr/ 86 Sr that had been given in summary form by W.H. Burke and coworkers. All Cenozoic samples (128) and 22 Cretaceous samples are foram-nannofossil oozes and limestones from DSDP cores distributed among 13 sites in the Atlantic, Pacific and Indian Oceans, and the Caribbean Sea. Non-DSDP Cretaceous samples (126) include limestone, anhydrite and phosphate samples from North America, Europe and Asia. Determination of the 87 Sr/ 86 Sr value of seawater at particular times in the past is based on comparison of ratios derived from coeval marine samples from widely separated geographic areas. The general configuration of the Cenozoic and Cretaceous curve appears to be strongly influenced by the history of plate interactions and sea-floor spreading. Specific rises and falls in the 87 Sr/ 86 Sr of seawater, however, may be caused by a variety of factors such as variation in lithologic composition of the crust exposed to weathering, configuration and topographic relief of continents, volcanic activity, rate of sea-floor spreading, extent of continental inundation by epeiric seas, and variations in both climate and paleo-oceanographic conditions. Many or all of these factors are probably related to global tectonic processes, yet their combined effect on the temporal variation of seawater 87 Sr/ 86 Sr can complicate a direct plate-tectonic interpretation for portions of the seawater curve. (Auth.)

  18. 25 CFR 700.53 - Dwelling, replacement.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Dwelling, replacement. 700.53 Section 700.53 Indians THE... Policies and Instructions Definitions § 700.53 Dwelling, replacement. The term replacement dwelling means a dwelling selected by the head of a household as a replacement dwelling that meets the criteria of this...

  19. 24 CFR 880.602 - Replacement reserve.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserve. 880.602... Replacement reserve. (a) A replacement reserve must be established and maintained in an interest-bearing account to aid in funding extraordinary maintenance and repair and replacement of capital items. (1) Part...

  20. 24 CFR 891.405 - Replacement reserve.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserve. 891.405....405 Replacement reserve. (a) Establishment of reserve. The Owner shall establish and maintain a replacement reserve to aid in funding extraordinary maintenance and repair and replacement of capital items...

  1. 24 CFR 891.855 - Replacement reserves.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserves. 891.855... § 891.855 Replacement reserves. (a) The mixed-finance owner shall establish and maintain a replacement... the funds will be used to pay for capital replacement costs for the Section 202 or 811 supportive...

  2. A Bayesian perspective on some replacement strategies

    International Nuclear Information System (INIS)

    Mazzuchi, Thomas A.; Soyer, Refik

    1996-01-01

    In this paper we present a Bayesian decision theoretic approach for determining optimal replacement strategies. This approach enables us to formally incorporate, express, and update our uncertainty when determining optimal replacement strategies. We develop relevant expressions for both the block replacement protocol with minimal repair and the age replacement protocol and illustrate the use of our approach with real data

  3. [The National Serum Bank].

    Science.gov (United States)

    Magos-López, C; Sánchez-Villarreal, F; Gutiérrez, G; Tapia-Conyer, R

    1992-01-01

    A National Serum Bank was established to store sera obtained during the National Seroepidemiological Survey performed in Mexico in 1987. More than 70,000 serum samples were obtained from subjects of either sex 1-99 years of age in each of the 32 states of the country. The current collection of sera includes 28,704 male samples and 40,629 female samples. This paper describes the procedures for handling serum samples, including reception registry, storage and distribution to several laboratories for detection of measles, rubella, poliomyelitis, AIDS, diphtheria, pertussis, tetanus, brucella, salmonella, amoeba, toxoplasma, American trypanosomiasis and cysticercus. Determinations of total cholesterol were also made in order to describe its distribution and to identify the prevalence of hypercholesterolemia.

  4. Effect of Sr/Ti Ratio on the Photocatalytic Properties of SrTiO3

    International Nuclear Information System (INIS)

    Sulaeman, U; Yin, S; Sato, T

    2011-01-01

    Since strontium titanate is a wide gap semiconductor, it requires UV light to generate the photocatalytic activities. Modification of strontium titanate to show photocatalytic activity under visible light irradiation is the essential work to efficiently utilize the sun light energy for environmental application. It is expected that the synthesis of SrTiO 3 with variation of Sr/Ti atomic ratio could induce the defect crystals having unique photocatalytic properties. The SrTiO 3 with various Sr/Ti atomic ratios were synthesized by microwave-assisted solvothermal reaction of SrCl 2 .6H 2 O and Ti(OC 3 H 7 ) 4 in KOH aqueous solutions with different atomic ratios of Sr/Ti. The products were characterized by TG-DTA, XRD and DRS. The photocatalytic activity was determined by DeNO x ability using LED lamps with the wavelengths of 627 nm (red), 530 nm (green), 445 nm (blue) and 390 nm (UV). The nanoparticles of perovskite type SrTiO 3 with the particle size of 30-40 nm were successfully synthesized. The visible light responsive photocatalytic activity was generated by adding excess amount of Sr. The photocatalytic activity in visible light could be enhanced by an increase in the Sr/Ti atomic ratio up to 1.25, indicating that the visible light responsive photocatalytic activity is due to the generation of new band gap between the conduction band and valence band of SrTiO 3 by the formation of oxygen vacancy.

  5. Acute renal insufficiency and renal replacement therapy after pediatric cardiopulmonary bypass surgery

    NARCIS (Netherlands)

    Kist-van Holthe tot Echten, J. E.; Goedvolk, C. A.; Doornaar, M. B.; van der Vorst, M. M.; Bosman-Vermeeren, J. M.; Brand, R.; van der Heijden, A. J.; Schoof, P. H.; Hazekamp, M. G.

    2001-01-01

    The aim of the study was to investigate renal function and renal replacement therapy after cardiopulmonary bypass surgery in children. Patient characteristics (sex, age, diagnosis), operation type, and death were listed. The study was performed retrospectively using serum creatinine level before,

  6. Modifications to Replacement Costs System

    International Nuclear Information System (INIS)

    Godec, M.

    1989-01-01

    The purpose of this memorandum is to document the improvements and modifications made to the Replacement Costs of Crude Oil (REPCO) Supply Analysis System. While some of this work was performed under our previous support contract to DOE/ASFE, we are presenting all modifications and improvements are presented here for completeness. The memo primarily documents revisions made to the Lower-48 Onshore Model. Revisions and modifications made to other components and models in the REPCO system which are documented elsewhere are only highlighted in this memo. Generally, the modifications made to the Lower-48 Onshore Model reflect changes that have occurred in domestic drilling, oil field costs, and reserves since 1982, the date of the most recent available data used for the original Replacement Costs report, published in 1985

  7. Results of Austin Moore replacement.

    Directory of Open Access Journals (Sweden)

    Jadhav A

    1996-04-01

    Full Text Available Forty cases of Austin Moore Replacement done for transcervical fractures of the femur in patients were reviewed after a period of 12 to 48 months postoperatively (mean 26 mth. 30 cases (75% had mild to severe pain of non-infective origin, starting as early as 6 months postoperatively. This was irrespective of the make, size or position (varus/valgus of the prosthesis. Though the Aufranc and Sweet clinical scoring was satisfactory in 65% cases, radiological evidence of complications like sinking, protrusion, etc. were seen in majority of the cases. Calcar resorption was seen in 34 cases (85% as early as 4 months postoperatively. Results of THR and bipolar replacement done for transcervical fractures in recent literature show 85% pain-free cases at 5 years. We feel that Austin Moore Replacement should be reserved for patients more than 65 years of age and those who are less active or debilitated because of other factors, because of increased acetabular wear with time in the younger individual. This is corroborated by unsatisfactory results in patients less than 65 years of age (p < 0.05.

  8. The caudal septum replacement graft.

    Science.gov (United States)

    Foda, Hossam M T

    2008-01-01

    To describe a technique for reconstructing the lost tip support in cases involving caudal septal and premaxillary deficiencies. The study included 120 patients with aesthetic and functional nasal problems resulting from the loss of caudal septal and premaxillary support. An external rhinoplasty approach was performed to reconstruct the lost support using a cartilaginous caudal septum replacement graft and premaxillary augmentation with Mersilene mesh. The majority of cases (75%) involved revisions in patients who had previously undergone 1 or more nasal surgical procedures. A caudal septum replacement graft was combined with premaxillary augmentation in 93 patients (77.5%). The mean follow-up period was 3 years (range, 1-12 years). The technique succeeded in correcting the external nasal deformities in all patients and resulted in a significant improvement in breathing in 74 patients (86%) with preoperative nasal obstruction. There were no cases of infection, displacement, or extrusion. The caudal septum replacement graft proved to be very effective in restoring the lost tip support in patients with caudal septal deficiency. Combining the graft with premaxillary augmentation using Mersilene mesh helped increase support and stability over long-term follow-up.

  9. BWR control blade replacement strategies

    Energy Technology Data Exchange (ETDEWEB)

    Kennard, M W [Stoller Nuclear Fuel, NAC International, Pleasantville, NY (United States); Harbottle, J E [Stoller Nuclear Fuel, NAC International, Thornbury, Bristol (United Kingdom)

    2000-02-01

    The reactivity control elements in a BWR, the control blades, perform three significant functions: provide shutdown margin during normal and accident operating conditions; provide overall core reactivity control; and provide axial power shaping control. As such, the blades are exposed to the core's neutron flux, resulting in irradiation of blade structural and absorber materials. Since the absorber depletes with time (if B{sub 4}C is used, it also swells) and the structural components undergo various degradation mechanisms (e.g., embrittlement, corrosion), the blades have limits on their operational lifetimes. Consequently, BWR utilities have implemented strategies that aim to maximize blade lifetimes while balancing operational costs, such as extending a refuelling outage to shuffle high exposure blades. This paper examines the blade replacement strategies used by BWR utilities operating in US, Europe and Asia by assembling information related to: the utility's specific blade replacement strategy; the impact the newer blade designs and changes in core operating mode were having on those strategies; the mechanical and nuclear limits that determined those strategies; the methods employed to ensure that lifetime limits were not exceeded during operation; and blade designs used (current and replacement blades). (author)

  10. BWR control blade replacement strategies

    International Nuclear Information System (INIS)

    Kennard, M.W.; Harbottle, J.E.

    2000-01-01

    The reactivity control elements in a BWR, the control blades, perform three significant functions: provide shutdown margin during normal and accident operating conditions; provide overall core reactivity control; and provide axial power shaping control. As such, the blades are exposed to the core's neutron flux, resulting in irradiation of blade structural and absorber materials. Since the absorber depletes with time (if B 4 C is used, it also swells) and the structural components undergo various degradation mechanisms (e.g., embrittlement, corrosion), the blades have limits on their operational lifetimes. Consequently, BWR utilities have implemented strategies that aim to maximize blade lifetimes while balancing operational costs, such as extending a refuelling outage to shuffle high exposure blades. This paper examines the blade replacement strategies used by BWR utilities operating in US, Europe and Asia by assembling information related to: the utility's specific blade replacement strategy; the impact the newer blade designs and changes in core operating mode were having on those strategies; the mechanical and nuclear limits that determined those strategies; the methods employed to ensure that lifetime limits were not exceeded during operation; and blade designs used (current and replacement blades). (author)

  11. Radioimmunoassay of haloperidol in human serum: correlation of serum haloperidol with serum prolactin

    International Nuclear Information System (INIS)

    Poland, R.E.; Rubin, R.T.

    1981-01-01

    A radioimmunoassay (RIA) for measurement of serum haloperidol is described. Compared to gaschromatography (GC), RIA vaues average 40% higher. However, a simple organic extraction of serum yields statistically equivalent RIA and GC haloperidol determinations. For both men and women combined, there was a positive correlation between dose (mg/kg/day) and steady-state serum haloperidol level (r = +0.86) and between steady-state serum haloperidol and serum prolactin (PRL) concentration

  12. RADIOISOTOPE INVENTORY FOR TSPA-SR

    International Nuclear Information System (INIS)

    Leigh, C.; Rechard, R.

    2001-01-01

    The total system performance assessment for site recommendation (TSPA-SR), on Yucca Mountain, as a site (if suitable) for disposal of radioactive waste, consists of several models. The Waste Form Degradation Model (i.e, source term) of the TSPA-SR, in turn, consists of several components. The Inventory Component, discussed here, defines the inventory of 26 radioisotopes for three representative waste categories: (1) commercial spent nuclear fuel (CSNF), (2) US Department of Energy (DOE) spent nuclear fuel (DSNF), and (3) high-level waste (HLW). These three categories are contained and disposed of in two types of waste packages (WPs)--CSNF WPs and co-disposal WPs, with the latter containing both DSNF and HLW. Three topics are summarized in this paper: first, the transport of radioisotopes evaluated in the past; second, the development of the inventory for the two WP types; and third, the selection of the most important radioisotopes to track in TSPA-SR

  13. Facile Synthesis of SrCO3-Sr(OH2/PPy Nanocomposite with Enhanced Photocatalytic Activity under Visible Light

    Directory of Open Access Journals (Sweden)

    Alfredo Márquez-Herrera

    2016-01-01

    Full Text Available Pyrrole monomer was chemically polymerized onto SrCO3-Sr(OH2 powders to obtain SrCO3-Sr(OH2/polypyrrole nanocomposite to be used as a candidate for photocatalytic degradation of methylene blue dye (MB. The material was characterized by Fourier transform infrared (FTIR spectroscopy, UV/Vis spectroscopy, and X-ray diffraction (XRD. It was observed from transmission electronic microscopy (TEM analysis that the reported synthesis route allows the production of SrCO3-Sr(OH2 nanoparticles with particle size below 100 nm which were embedded within a semiconducting polypyrrole matrix (PPy. The SrCO3-Sr(OH2 and SrCO3-Sr(OH2/PPy nanocomposites were tested in the photodegradation of MB dye under visible light irradiation. Also, the effects of MB dye initial concentration and the catalyst load on photodegradation efficiency were studied and discussed. Under the same conditions, the efficiency of photodegradation of MB employing the SrCO3-Sr(OH2/PPy nanocomposite increases as compared with that obtained employing the SrCO3-Sr(OH2 nanocomposite.

  14. Serum YKL-40

    DEFF Research Database (Denmark)

    Mylin, Anne K; Abildgaard, Niels; Johansen, Julia S

    2015-01-01

    to clinical progression, i.e. skeletal-related events (SREs), in 230 newly diagnosed patients with multiple myeloma receiving intravenous bisphosphonates. Serum concentrations of YKL-40 and biochemical bone markers (CTX-MMP, CTX-I, PINP) were measured at diagnosis. Patients were evaluated every third month...

  15. 79 - 81_Wali - Serum

    African Journals Online (AJOL)

    DR. AMINU

    2013-06-01

    Jun 1, 2013 ... SERUM ANTIOXIDANT VITAMINS LEVELS IN CHILDREN WITH SICKLE. CELL ANAEMIA IN ... play a role in the development of sickle cell anaemic complications. In the current study, ... vaso-occlusive episodes, acute chest syndrome and impaired ... frequency of sickling crises accompanied by tissue or.

  16. C, Sr and Sr isotopic composition on probable vendian- tommotian carbonate sequences in Nw Argentina

    International Nuclear Information System (INIS)

    Sial, A. N.; Ferreira, V.P; Toselli, A.J.; Acenolaza, F.G; Pimentel, M.M; Parada, M.A; Alonso, R.N

    2001-01-01

    C-isotope stratigraphy is one of the most powerfool tools in Precambrian chronostratigraphy, especially when sediments lack recognizable animal fossils. The δ 13 C secular variation curves for marine carbonates in the Neoproterozoic-Cambrian interval show strong positive-negative excursions, several of them interpreted as the stratigraphic position of ancient ice ages (Hoffman et al. 1998). The Sr isotope composition of the seawater for this age interval is characterized by a continuous increase of 87 Sr/ 86 Sr that is interrupted, several times, by sharp rises, which represent important changes in the Earth history (Montanez et al. 2000). Only limited data on the behavior of C and Sr isotopes in carbonates are available in South America. We examine here carbonate sequences from the Argentine Precordillera, San Juan province, and from other carbonate sequences in NW Argentina that could be, potentially, proxies for the Precambrian-Cambrian transition. We have studied their δ 13 C and 87 Sr/ 86 Sr chemostratigraphy and compare it to global C and Sr isotope secular variation curves for this time span. This study aims to improve the relatively coarse stratigraphic resolution provided only by the study of the fossil record in some of the carbonate successions under consideration (au)

  17. The structure of 83Sr excited states

    International Nuclear Information System (INIS)

    Liptak, J.; Kristiak, J.; Kristiakova, K.

    1976-01-01

    The β-decay of 83 Y isomers (7.06 min and 2.85 min) have been studied by means of Ge(Li) detectors. The proposed level scheme of the 83 Sr nucleus is based on the coincidence measurement and the analysis of energy sums. The intensity balance requirement leads to αsub(T)(35.5keV)=3.2 which is consistent with M1 multipolarity of this transition. A probable structure of some of the excited states in the 83 Sr nucleus is discussed in the frame work of Alaga's model and Kuriyama's model

  18. Principles of μSR technics

    International Nuclear Information System (INIS)

    Chappert, J.

    1983-05-01

    Principles of muon spin rotation spectroscopy (μSR) are presented. Muons plus are only take into account because physical and chemical results obtained presently are obtained by them. Muon plus has two main characteristics when implanted in a sample: just, it can be considered as a interstitial site probe; then the muon plus can diffuse. Accordingly the quantities measured by μSR are a combination of static and dynamic properties of the muon plus and of the sample. A fluid characteristics is the possibility of munomium formation (μ + e - bound state) [fr

  19. SR 97 - Identification and structuring of process

    International Nuclear Information System (INIS)

    Pers, K.; Skagius, K.; Soedergren, S.; Wiborgh, M.; Hedin, A.; Moren, L.; Sellin, P.; Stroem, A.; Pusch, R.; Bruno, J.

    1999-12-01

    This report documents work conducted in recent years to identify processes and interactions of importance to the evaluation of long-term safety of a KBS 3 type deep repository for spent nuclear fuel. Previous, partly undocumented work regarding interaction matrices is described as well as the THMC diagrams that have been used in the safety assessment SR 97. The coupling between the two sources of information is documented in a database. In the same database, the interaction matrices are briefly documented, while the processes in the THMC diagrams are more thoroughly documented in a special so called Process Report, which forms an important supporting document for SR 97

  20. SR-71 Pilot Stephen (Steve) D. Ishmael

    Science.gov (United States)

    1992-01-01

    NASA research pilot Stephen D. Ishmael is pictured here in front of an SR-71 Blackbird on the ramp at the Dryden Flight Research Center, Edwards, California. Ishmael was one of two NASA research pilots assigned to the SR-71 high speed research program in the early 1990s at NASA's Dryden Flight Research Facility (redesignated the Dryden Flight Research Center in 1994), Edwards, California. Ishmael became a NASA research pilot in 1977. Data from the SR-71 program will be used to aid designers of future supersonic aircraft and propulsion systems. Two SR-71 aircraft have been used by NASA as testbeds for high-speed and high-altitude aeronautical research. The aircraft, an SR-71A and an SR-71B pilot trainer aircraft, have been based here at NASA's Dryden Flight Research Center, Edwards, California. They were transferred to NASA after the U.S. Air Force program was cancelled. As research platforms, the aircraft can cruise at Mach 3 for more than one hour. For thermal experiments, this can produce heat soak temperatures of over 600 degrees Fahrenheit (F). This operating environment makes these aircraft excellent platforms to carry out research and experiments in a variety of areas -- aerodynamics, propulsion, structures, thermal protection materials, high-speed and high-temperature instrumentation, atmospheric studies, and sonic boom characterization. The SR-71 was used in a program to study ways of reducing sonic booms or over pressures that are heard on the ground, much like sharp thunderclaps, when an aircraft exceeds the speed of sound. Data from this Sonic Boom Mitigation Study could eventually lead to aircraft designs that would reduce the 'peak' overpressures of sonic booms and minimize the startling affect they produce on the ground. One of the first major experiments to be flown in the NASA SR-71 program was a laser air data collection system. It used laser light instead of air pressure to produce airspeed and attitude reference data, such as angle of attack and

  1. SR 97 - Identification and structuring of process

    Energy Technology Data Exchange (ETDEWEB)

    Pers, K.; Skagius, K.; Soedergren, S.; Wiborgh, M. [Kemakta Konsult AB, Stockholm (Sweden); Hedin, A.; Moren, L.; Sellin, P.; Stroem, A. [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Pusch, R. [Geodevelopment AB, Lund (Sweden); Bruno, J. [QuantiSci SL, Barcelona (Spain)

    1999-12-01

    This report documents work conducted in recent years to identify processes and interactions of importance to the evaluation of long-term safety of a KBS 3 type deep repository for spent nuclear fuel. Previous, partly undocumented work regarding interaction matrices is described as well as the THMC diagrams that have been used in the safety assessment SR 97. The coupling between the two sources of information is documented in a database. In the same database, the interaction matrices are briefly documented, while the processes in the THMC diagrams are more thoroughly documented in a special so called Process Report, which forms an important supporting document for SR 97.

  2. Relationship between serum calcium and CA 19-9 levels in colorectal cancer

    Science.gov (United States)

    Fuszek, Peter; Lakatos, Peter; Tabak, Adam; Papp, Janos; Nagy, Zsolt; Takacs, Istvan; Horvath, Henrik Csaba; Lakatos, Peter Laszlo; Speer, Gabor

    2004-01-01

    AIM: To examine the calcium metabolism of colorectal cancer (CRC) in patients with colorectal cancer and control patients. METHODS: Seventy newly diagnosed CRC patients were included. The healthy control group was age and gender matched (n = 32). Particular attention was devoted to the relationship between serum calcium of patients, and levels of AFP, CEA, carbohydrate antigen 19-9 (CA 19-9) (that could be considered as prognostic factors). Furthermore, the Ca-sensing receptor (CaSR) gene A986S polymorphism was investigated in these patients, as well as the relationship between different CaSR genotypes and the data stated above. RESULTS: A lower level of ionized calcium (also corrected for albumin) was found in the serum of CRC patients with normal 25 (OH) vitamin D levels. The ionized calcium concentration was inversely correlated with the serum level of CA 19-9. There was no difference in the distribution of CaSR genotypes, between CRC patients and general population. The genotypes did not correlate with other data examined. CONCLUSION: Based on these results, lower levels of serum calcium might be a pathogenic and prognostic factor in colorectal cancer. PMID:15222030

  3. Thermal conductivity of M-Si-N (M = Mg, Ca, Sr, Ba) compounds with varying M/Si ratio

    NARCIS (Netherlands)

    Hintzen, H.T.J.M.; Bruls, R.J.; Delsing, A.C.A.; Itatani, K.; Tanaka, S.; With, de G.; Metselaar, R.

    2002-01-01

    The thermal cond. of M-Si-N (M = Mg, Ca, Sr, Ba) compds. was examd. The emphasis is on MgSiN2 (a material which can be derived from AlN by replacing systematically 2Al3+ by Mg2+/Si4+), and Si3N4 (the well known b-modification as well as the recently discovered cubic modification with the spinel

  4. Serum Lipid Profile: Fasting or Non-fasting?

    OpenAIRE

    Nigam, P. K.

    2010-01-01

    Serum lipid profile has now become almost a routine test. It is usually done in fasting state due to certain limitations in non-fasting serum sample. In the recent past efforts have been made to simplify blood sampling by replacing fasting lipid profile with non-fasting lipid profile. However, fasting specimen is preferred if cardiovascular risk assessment is based on total cholesterol, LDL cholesterol or non-HDL cholesterol. A lot has yet to be done in this area. Till then we have to believe...

  5. Geochronological synthesis of Bahia state and the crustal evolution, based in evolution diagram of Sr and initial rate of Sr87/Sr86

    International Nuclear Information System (INIS)

    Sato, K.

    1986-01-01

    The crustal evolution of the ancient terrains of the State of Bahia, Brazil, is attempted with the aid of Sr isotopic results as natural tracers. Some Nd and Pb isotopic data are also available, and support the main conclusions based on Sr evolution diagrams. The analysis of the Sr evolution diagrams shows that the Archean Terrains are mainly formed by accretion from mantle-derived material, but crustal reworking is indicated by the high initial 87 Sr/ 86 Sr value of the Jequie Complex. The Transamazonian mobile belt include both types of materials, but the 87 Sr/ 86 Sr value, generally lower than those of the Jequie Complex, markes improbable a direct derivation. During Middle and Late Proterozoic, the continental crust was already well consolidated, and reworking of crustal material predominated within the Espinhaco and Brasiliano folded systems [pt

  6. Structural and compositional characterization of synthetic (Ca,Sr)-tremolite and (Ca,Sr)-diopside solid solutions

    Science.gov (United States)

    Gottschalk, M.; Najorka, J.; Andrut, M.

    Tremolite (CaxSr1-x)2Mg5[Si8O22/(OH)2] and diopside (CaxSr1-x)Mg[Si2O6] solid solutions have been synthesized hydrothermally in equilibrium with a 1 molar (Ca,Sr)Cl2 aqueous solution at 750°C and 200 MPa. The solid run products have been investigated by optical, electron scanning and high resolution transmission electron microscopy, electron microprobe, X-ray-powder diffraction and Fourier-transform infrared spectroscopy. The synthesized (Ca,Sr)-tremolites are up to 2000 µm long and 30 µm wide, the (Ca,Sr)-diopsides are up to 150 µm long and 20 µm wide. In most runs the tremolites and diopsides are well ordered and chain multiplicity faults are rare. Nearly pure Sr-tremolite (tr0.02Sr-tr0.98) and Sr-diopside (di0.01Sr-di0.99) have been synthesized. A continuous solid solution series, i.e. complete substitution of Sr2+ for Ca2+ on M4-sites exists for (Ca,Sr)-tremolite. Total substitution of Sr2+ for Ca2+ on M2-sites can be assumed for (Ca,Sr)-diopsides. For (Ca,Sr)-tremolites the lattice parameters a, b and β are linear functions of composition and increase with Sr-content whereas c is constant. For the diopside series all 4 lattice parameters are a linear function of composition; a, b, c increase and β decreases with rising Sr-content. The unit cell volume for tremolite increases 3.47% from 906.68 Å3 for tremolite to 938.21 Å3 for Sr-tremolite. For diopside the unit cell volume increases 4.87 % from 439.91 Å3 for diopside to 461.30 Å3 for Sr-diopside. The observed splitting of the OH stretching band in tremolite is caused by different configurations of the next nearest neighbors (multi mode behavior). Resolved single bands can be attributed to the following configurations on the M4-sites: SrSr, SrCa, CaCa and CaMg. The peak positions of these 4 absorption bands are a linear function of composition. They are shifted to lower wavenumbers with increasing Sr-content. No absorption band due to the SrMg configuration on the M4-site is observed. This indicates

  7. Report on nuclear energy in SR Slovenia; Porocilo o uporabi jedrske energije v SR Sloveniji

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1987-07-01

    Currently Yugoslavia has one 632 MWe nuclear power plant (NPP) of PWR design, located at Krsko in the Socialist Republic (SR) of Slovenia. Krsko NPP, which is a two-loop plant, started power operation in 1981. In general, reactor safety activities in the SR of Slovenia are mostly related to upgrading the safety of our Krsko NPP and to developing capabilities for use in future units. This report presents the nuclear safety related legislation and organization of the corresponding regulatory body, and the activities related to nuclear safety of the participating organizations in the SR of Slovenia in 1987.

  8. A high 87Sr 86Sr mantle source for low alkali tholeiite, northern Great Basin

    Science.gov (United States)

    Mark, R.K.; Lee, Hu C.; Bowman, H.R.; Asaro, F.; McKee, E.H.; Coats, R.R.

    1975-01-01

    Olivine tholeiites, the youngest Tertiary units (about 8-11 m.y. old) at five widely spaced localities in northeastern Nevada, are geologically related to the basalts of the Snake River Plain, Idaho, to the north and are similar in major element and alkali chemistry to mid-ocean ridge basalts (MORB) and island arc tholeiites. The measured K (1250-3350 ppm), Rb (1??9-6??2 ppm) and Sr (140-240 ppm) concentrations overlap the range reported for MORB. Three of the five samples have low, unfractionated rare earth element (REE) patterns, the other two show moderate light-REE enrichment. Barium concentration is high and variable (100-780 ppm) and does not correlate with the other LIL elements. The rocks have 87Sr/86Sr = 0??7052-0??7076, considerably higher than MORB (~0??702-0??703). These samples are chemically distinct (i.e. less alkalic) from the olivine tholeiites from the adjacent Snake River Plain, but their Sr isotopic compositions are similar. They contain Sr that is distinctly more radiogenic than the basalts from the adjacent Great Basin. About 10 b.y. would be required for the mean measured Rb/Sr (~ 0??02) of these samples to generate, in a closed system, the radiogenic Sr they contain. The low alkali content of these basalts makes crustal contamination an unlikely mechanism. If the magma is uncontaminated, the time-averaged Rb/Sr of the source material must have been ~0??04. A significant decrease in Rb/Sr of the source material (a factor 2??) thus most probably occurred in the relatively recent (1??09 yr) past. Such a decrease of Rb/Sr in the mantle could accompany alkali depletion produced by an episode of partial melting and magma extraction. In contrast, low 87Sr 86Sr ratios indicate that the source material of the mid-ocean ridge basalts may have been depleted early in the Earth's history. ?? 1975.

  9. FEP report for the safety assessment SR-Site

    Energy Technology Data Exchange (ETDEWEB)

    2010-12-15

    This report documents the analysis and processing of features, events and processes, FEPs, that has been carried out within the safety assessment SR-Site, and forms an important part of the reporting of the project. The main part of the work was conducted within the earlier safety assessment SR-Can, which was a preparatory stage for the SR-Site assessment. The overall objective of the FEP analysis and processing in both SR-Can and SR-Site included development of a database of features, events and processes, an SKB FEP database, in a format that facilitates both a systematic analysis of FEPs and documentation of that FEP analysis, as well as facilitating revisions and updates to be made in connection with new safety assessments. The primary objective in SR-Site was to establish an SR-Site FEP catalogue within the framework of the SKB FEP database. This FEP catalogue was required to contain all FEPs that needed to be handled in SR-Site and is an update of the corresponding SR-Can FEP catalogue that was established for the SR-Can assessment. The starting point for the handling of FEPs in SR-Site was the SR-Can version of the SKB FEP database and associated SR-Can reports. The SR-Can version of the SKB FEP database includes the SR-Can FEP catalogue, as well as the sources for the identification of FEPs in SR-Can, namely the SR 97 processes and variables, Project FEPs in the NEA International FEP database version 1.2 and matrix interactions in the Interaction matrices developed for a deep repository of the KBS-3 type. Since the completion of the FEP work within SR-Can, an updated electronic version, version 2.1, of the NEA FEP database has become available. Compared with version 1.2 of the NEA FEP database, version 2.1 contains FEPs from two more projects. As part of SR-Site, all new Project FEPs in version 2.1 of the NEA FEP database have been mapped according to the methodology adopted in SR-Can resulting in an SR-Site version of the SKB FEP database. The SKB FEP

  10. FEP report for the safety assessment SR-Site

    International Nuclear Information System (INIS)

    2010-12-01

    This report documents the analysis and processing of features, events and processes, FEPs, that has been carried out within the safety assessment SR-Site, and forms an important part of the reporting of the project. The main part of the work was conducted within the earlier safety assessment SR-Can, which was a preparatory stage for the SR-Site assessment. The overall objective of the FEP analysis and processing in both SR-Can and SR-Site included development of a database of features, events and processes, an SKB FEP database, in a format that facilitates both a systematic analysis of FEPs and documentation of that FEP analysis, as well as facilitating revisions and updates to be made in connection with new safety assessments. The primary objective in SR-Site was to establish an SR-Site FEP catalogue within the framework of the SKB FEP database. This FEP catalogue was required to contain all FEPs that needed to be handled in SR-Site and is an update of the corresponding SR-Can FEP catalogue that was established for the SR-Can assessment. The starting point for the handling of FEPs in SR-Site was the SR-Can version of the SKB FEP database and associated SR-Can reports. The SR-Can version of the SKB FEP database includes the SR-Can FEP catalogue, as well as the sources for the identification of FEPs in SR-Can, namely the SR 97 processes and variables, Project FEPs in the NEA International FEP database version 1.2 and matrix interactions in the Interaction matrices developed for a deep repository of the KBS-3 type. Since the completion of the FEP work within SR-Can, an updated electronic version, version 2.1, of the NEA FEP database has become available. Compared with version 1.2 of the NEA FEP database, version 2.1 contains FEPs from two more projects. As part of SR-Site, all new Project FEPs in version 2.1 of the NEA FEP database have been mapped according to the methodology adopted in SR-Can resulting in an SR-Site version of the SKB FEP database. The SKB FEP

  11. Monitoring of glycolytic activity secondary to ischaemia in knee replacement surgery.

    Science.gov (United States)

    León-Muñoz, V J; Lisón-Almagro, A J; Hernández-García, C H; López-López, M

    2018-04-17

    To non-invasively assess tissue lesion secondary to ischaemia applied during knee replacement surgery. Secondary objectives: to assess whether this lesion correlates with the duration of ischaemia and whether instrumental and gender variables influence it. Prospective cohort study. Pre and postoperative serum lactate levels have been determined as an indicator of glycolytic activity secondary to ischaemia in 88 patients. Serum lactate determination was performed by reactive strips of enzymatic-amperometric detection on capillary blood. Preoperative serum lactate levels (mean and SD): 2.467±1.036 mmol/L. Postoperative serum lactate levels: 3.938±2.018 mmol/L. Ischaemia time 102.98±18.25minutes. Postoperative serum lactate levels were significantly higher than preoperative lactate levels. There are no statistical differences according to the time that the ischaemia was prolonged, gender or type of instrumentation used. In our study, postoperative serum lactate values were significantly higher than preoperative lactate values, with no correlation to the duration of ischaemia during knee replacement surgery. Copyright © 2018 SECOT. Publicado por Elsevier España, S.L.U. All rights reserved.

  12. Mg- and/or Sr-doped tricalcium phosphate/bioactive glass composites: Synthesis, microstructure and biological responsiveness

    Energy Technology Data Exchange (ETDEWEB)

    Bellucci, Devis, E-mail: devis.bellucci@unimore.it [Department of Engineering “E. Ferrari”, University of Modena and Reggio Emilia, Via Vignolese 905, 41125 Modena (Italy); Sola, Antonella [Department of Engineering “E. Ferrari”, University of Modena and Reggio Emilia, Via Vignolese 905, 41125 Modena (Italy); Cacciotti, Ilaria [University of Rome " Niccolò Cusano" , UdR INSTM, Via Don Carlo Gnocchi 3, 00166, Rome (Italy); Bartoli, Cristina; Gazzarri, Matteo [Department of Chemistry and Industrial Chemistry, University of Pisa, UdR INSTM — Pisa, Via Risorgimento 35, 56127 Pisa (Italy); Bianco, Alessandra [Department of Enterprise Engineering, INSTM RU “Rome-Tor Vergata”, Via del Politecnico 1, 00133 Roma (Italy); Chiellini, Federica [Department of Chemistry and Industrial Chemistry, University of Pisa, UdR INSTM — Pisa, Via Risorgimento 35, 56127 Pisa (Italy); Cannillo, Valeria [Department of Engineering “E. Ferrari”, University of Modena and Reggio Emilia, Via Vignolese 905, 41125 Modena (Italy)

    2014-09-01

    Presently, there is an increasing interest towards the composites of calcium phosphates, especially β-tricalcium phosphate (TCP), and bioactive glasses. In the present contribution, the recently developed BG{sub C}a/Mix glass has been used because its low tendency to crystallize allows to sinter the composites at relatively low temperature (i.e. 850 °C), thus minimizing the glass devitrification and the interaction with TCP. A further improvement is the introduction of lab-produced TCP powders doped with specific ions instead of non-doped commercial powders, since the biological properties of materials for bone replacement can be modulated by doping them with certain metallic ions, such as Mg and Sr. Therefore, novel binary composites have been produced by sintering the BG{sub C}a/Mix glass with the addition of pure, Mg-substituted, Sr-substituted or Mg/Sr bisubstituted TCP powders. After an accurate characterization of the starting TCP powders and of the obtained samples, the composites have been used as three-dimensional supports for the culture of mouse calvaria-derived pre-osteoblastic cells. The samples supported cell adhesion and proliferation and induced promising mechanisms of differentiation towards an osteoblastic phenotype. In particular, the Mg/Sr bi-doped samples seemed to better promote the differentiation process thus suggesting a combined stimulatory effect of Mg{sup 2+} and Sr{sup 2+} ions.

  13. Mg- and/or Sr-doped tricalcium phosphate/bioactive glass composites: Synthesis, microstructure and biological responsiveness

    International Nuclear Information System (INIS)

    Bellucci, Devis; Sola, Antonella; Niccolò Cusano, UdR INSTM, Via Don Carlo Gnocchi 3, 00166, Rome (Italy))" data-affiliation=" (University of Rome Niccolò Cusano, UdR INSTM, Via Don Carlo Gnocchi 3, 00166, Rome (Italy))" >Cacciotti, Ilaria; Bartoli, Cristina; Gazzarri, Matteo; Bianco, Alessandra; Chiellini, Federica; Cannillo, Valeria

    2014-01-01

    Presently, there is an increasing interest towards the composites of calcium phosphates, especially β-tricalcium phosphate (TCP), and bioactive glasses. In the present contribution, the recently developed BG C a/Mix glass has been used because its low tendency to crystallize allows to sinter the composites at relatively low temperature (i.e. 850 °C), thus minimizing the glass devitrification and the interaction with TCP. A further improvement is the introduction of lab-produced TCP powders doped with specific ions instead of non-doped commercial powders, since the biological properties of materials for bone replacement can be modulated by doping them with certain metallic ions, such as Mg and Sr. Therefore, novel binary composites have been produced by sintering the BG C a/Mix glass with the addition of pure, Mg-substituted, Sr-substituted or Mg/Sr bisubstituted TCP powders. After an accurate characterization of the starting TCP powders and of the obtained samples, the composites have been used as three-dimensional supports for the culture of mouse calvaria-derived pre-osteoblastic cells. The samples supported cell adhesion and proliferation and induced promising mechanisms of differentiation towards an osteoblastic phenotype. In particular, the Mg/Sr bi-doped samples seemed to better promote the differentiation process thus suggesting a combined stimulatory effect of Mg 2+ and Sr 2+ ions

  14. Electron magnetic resonance of diluted solid solutions of Gd{sup 3+} in SrTiO{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Biasi, R.S. de, E-mail: rsbiasi@ime.eb.br [Secao de Engenharia Mecanica e de Materiais, Instituto Militar de Engenharia, 22290-270 Rio de Janeiro, RJ (Brazil); Grillo, M.L.N., E-mail: mluciag@uerj.br [Instituto de Fisica, Universidade do Estado do Rio de Janeiro, 20550-013 Rio de Janeiro, RJ (Brazil)

    2011-10-17

    Highlights: {yields} EMR is an effective method to study the range of the exchange interaction in solid solutions. {yields} The range of the exchange interaction between Gd{sup 3+} ions in SrTiO{sub 3} is about 0.96 nm. {yields} The linewidth increases faster with Gd concentration in SrTiO{sub 3} than in other host lattices, such as CeO{sub 2}, SrO, CaO and ZrSiO{sub 4}. - Abstract: Electron magnetic resonance (EMR) spectra of gadolinium-doped strontium titanate (SrTiO{sub 3}) have been studied at room temperature for gadolinium concentrations between 0.20 and 1.20 mol%. The results suggest that the Gd{sup 3+} ions occupy substitutional sites, replacing the Sr{sup 2+} ion, that the electron magnetic resonance linewidth increases with increasing gadolinium concentration and that the range of the exchange interaction between Gd{sup 3+} ions is about 0.96 nm, of the same order as that of the same ion in other host lattices, such as ceria (CeO{sub 2}), quicklime (CaO), strontia (SrO) and zircon (ZrSiO{sub 4}). The fact that the electron magnetic resonance linewidth of the Gd{sup 3+} ion increases, regularly and predictably, with Gd concentration, shows that the Gd{sup 3+} ion can be used as a probe to study, rapidly and non-destructively, the crystallinity and degradation of SrTiO{sub 3}.

  15. Gentilly 2 divider plate replacement

    International Nuclear Information System (INIS)

    Forest, J.; Klisel, E.; McClellan, G.; Schnelder, W.

    1995-01-01

    The steam generators at the Gentilly 2 Nuclear Plant in operation since 1983 were built with primary divider plates of a bolted panel configuration. During a routine outage inspection, it was noted that two bolts had dislodged from the divider and were located lying in the primary head. Subsequent inspections revealed erosion damage to a substantial number of divider plate bolts and to a lesser extent, to the divider plate itself. After further inspection and repair the units were returned to operation, however, it was determined that a permanent replacement of the primary divider plates was going to be necessary. After evaluation of various options, it was decided that the panel type dividers would be replaced with a single piece floating design. The divider itself was to be of a one piece all-welded arrangement to be constructed from individual panels to be brought in through the manways. In view of the strength limitations of the bolted attachment of the upper seat bar to the tubesheet, a new welded seat bar was provided. To counteract erosion concerns, the new divider is fitted with erosion resistant inserts or weld buildup and with improved sealing features in order to minimize leakage and erosion. At an advanced stage in the design and manufacture of the components, the issue of divider strength during LOCA conditions came into focus. Analysis was performed to determine the strength and/or failure characteristics of the divider to a variety of small and large LOCA conditions. The paper describes the diagnosis of the original divider plates and the design, manufacture, field mobilization, installation and subsequent operation of the replacement divider plates. (author)

  16. In Defense of Artificial Replacement.

    Science.gov (United States)

    Shiller, Derek

    2017-06-01

    If it is within our power to provide a significantly better world for future generations at a comparatively small cost to ourselves, we have a strong moral reason to do so. One way of providing a significantly better world may involve replacing our species with something better. It is plausible that in the not-too-distant future, we will be able to create artificially intelligent creatures with whatever physical and psychological traits we choose. Granted this assumption, it is argued that we should engineer our extinction so that our planet's resources can be devoted to making artificial creatures with better lives. © 2017 John Wiley & Sons Ltd.

  17. Characterization of proton in Y-doped SrZrO3 polycrystal by IR spectroscopy

    International Nuclear Information System (INIS)

    Hibino, T.; Mizutani, K.; Yajima, T.; Iwahara, H.

    1992-01-01

    To characterize proton in Y-doped SrZrO 3 polycrystal, protonic conductivities and infrared spectra were measured. IR spectra exhibited 2 OH bands in 3500-2800 and 2650-2300 cm -1 regions, indicating that proton was bound to lattice oxide ion and that its strength of bonding was rather weak. The decrease in conductivity by replacing H + with D + suggested that the conducting ion was not hydroxide but proton and that it migrated via the dissociation of O-H bond. (author). 15 refs., 5 figs

  18. The accumulation and elimination of 89Sr in tea leaves

    International Nuclear Information System (INIS)

    Zhang Yongxi; Wang Shouxiang; Chen Chuanqun; Sun Zhiming; Hu Bingmin; Huang Dan

    1995-01-01

    The 89 Sr was added to the tea tree-soil system by different ways. The 89 Sr in the system through the over-ground part of tea tree, was much more than that through soil. The 89 Sr concentration in older leaves was higher than in shoot for a definite treatment. The accumulation elimination law of 89 Sr in leaves varied with the treatments. For the treatment through the over-ground part, the 89 Sr concentration in older leaves and shoot was monotonously decreased with time increasing. But for the treatment through soil the 89 Sr concentration in shoot was increased to reach a peak value, and then decreased slowly; while the 89 Sr concentration in older leaves increased quickly in a period, then increased slowly to attain a saturated value. In addition, the concentration factor of 89 Sr in older leaves and shoot were determined

  19. Radionuclide transport report for the safety assessment SR-Site

    Energy Technology Data Exchange (ETDEWEB)

    2010-12-15

    This document compiles radionuclide transport calculations of a KBS-3 repository for the safety assessment SR-Site. The SR-Site assessment supports the licence application for a final repository at Forsmark, Sweden

  20. Human SR-BII mediates SAA uptake and contributes to SAA pro-inflammatory signaling in vitro and in vivo.

    Directory of Open Access Journals (Sweden)

    Irina N Baranova

    Full Text Available Serum amyloid A (SAA is an acute phase protein with cytokine-like and chemotactic properties, that is markedly up-regulated during various inflammatory conditions. Several receptors, including FPRL-1, TLR2, TLR4, RAGE, class B scavenger receptors, SR-BI and CD36, have been identified as SAA receptors. This study provides new evidence that SR-BII, splice variant of SR-BI, could function as an SAA receptor mediating its uptake and pro-inflammatory signaling. The uptake of Alexa Fluor488 SAA was markedly (~3 fold increased in hSR-BII-expressing HeLa cells when compared with mock-transfected cells. The levels of SAA-induced interleukin-8 secretion by hSR-BII-expressing HEK293 cells were also significantly (~3-3.5 fold higher than those detected in control cells. Moderately enhanced levels of phosphorylation of all three mitogen-activated protein kinases, ERK1/2, and p38 and JNK, were observed in hSR-BII-expressing cells following SAA stimulation when compared with control wild type cells. Transgenic mice with pLiv-11-directed liver/kidney overexpression of hSR-BI or hSR-BII were used to assess the in vivo role of each receptor in SAA-induced pro-inflammatory response in these organs. Six hours after intraperitoneal SAA injection both groups of transgenic mice demonstrated markedly higher (~2-5-fold expression levels of inflammatory mediators in the liver and kidney compared to wild type mice. Histological examinations of hepatic and renal tissue from SAA-treated mice revealed moderate level of damage in the liver of both transgenic but not in the wild type mice. Activities of plasma transaminases, biomarkers of liver injury, were also moderately higher in hSR-B transgenic mice when compared to wild type mice. Our findings identify hSR-BII as a functional SAA receptor that mediates SAA uptake and contributes to its pro-inflammatory signaling via the MAPKs-mediated signaling pathways.

  1. Determination of Sr-90 in the air

    International Nuclear Information System (INIS)

    Marovic, G.; Bajlo, M.; Bauman, A.

    1983-01-01

    Sr-90 concentrations were determined in high-volume air samples (up to 10000 m 3 ) during 12 months. In 1981 radioactivity varied around a value of 2.7 x 10 - 5 Bq m 3 . The results are in agreement with the activities recorded in the same year in New York, USA and in France. (author)

  2. Factors affecting 90Sr uptake from the ration

    International Nuclear Information System (INIS)

    Knizhnikov, V.A.; Marej, A.N.; Borisov, B.K.; Petukhova, Eh.V.

    1980-01-01

    The dependence of 90 Sr uptake in the human organism on nutrition peculiarities is shown. Strontium-90 polluting vegetable products due to particle sorption from the air is less available for the uptake than 90 Sr resorbed from the soil with vegetation. Therefore, this nuclide is uptaken more completely from milk which containes 90 Sr in a soluble form than from grain and bakery products which are polluted by 90 Sr largely by air

  3. Development of 87Sr/86Sr maps as targeted strategy to support wine quality.

    Science.gov (United States)

    Durante, Caterina; Bertacchini, Lucia; Cocchi, Marina; Manzini, Daniela; Marchetti, Andrea; Rossi, Maria Cecilia; Sighinolfi, Simona; Tassi, Lorenzo

    2018-07-30

    This study summarizes the results obtained from a systematic and long-term project aimed at the development of tools to assess the provenance of food in the oenological sector. In particular, 87 Sr/ 86 Sr isotope ratios were measured on statistically representative set of soils, vine branches and wines sampled in the production district of Modena, worldwide known for the Lambrusco wines production. The obtained data were used to build strontium isotopic maps able to objectively support the Lambrusco PDO wines origin as well as other products of the Modena district. Finally, a strong relationship was found between the 87 Sr/ 86 Sr isotope ratios of soils and vine branches on a large scale, highlighting and confirming once more the idea that plants can also represent an optimal sampling device to support geographical traceability. Copyright © 2018 Elsevier Ltd. All rights reserved.

  4. Hormone Replacement Therapy and Your Heart

    Science.gov (United States)

    Hormone replacement therapy and your heart Are you taking — or considering — hormone therapy to treat bothersome menopausal symptoms? Understand ... you. By Mayo Clinic Staff Long-term hormone replacement therapy used to be routinely prescribed for postmenopausal ...

  5. Skilled nursing facilities after joint replacement

    Science.gov (United States)

    ... care providers in the weeks before your joint replacement. They can advise you about whether going directly ... of many people who have had a joint replacement? Can they tell you how many? A good ...

  6. Risks of hip and knee replacement

    Science.gov (United States)

    ... is normal to lose blood during and after hip or knee replacement surgery. Some people need a ... clot form are higher during and soon after hip or knee replacement surgery. Sitting or lying down ...

  7. Fleet replacement modeling : final report, July 2009.

    Science.gov (United States)

    2009-07-01

    This project focused on two interrelated areas in equipment replacement modeling for fleets. The first area was research-oriented and addressed a fundamental assumption in engineering economic replacement modeling that all assets providing a similar ...

  8. Long-life slab replacement concrete : [summary].

    Science.gov (United States)

    2015-04-01

    Concrete slab replacement projects in Florida have demonstrated a high incidence of : replacement slab cracking. Causes of cracking have not been reliably determined. University of South Florida researchers : sought to identify the factors or : param...

  9. Long-life slab replacement concrete.

    Science.gov (United States)

    2015-03-01

    This research was initiated following reports of high incidence of cracking on FDOT concrete pavement replacement : slab projects. Field slabs were instrumented for data acquisition from high-early-strength concrete pavement : replacement slabs place...

  10. Serum Creatinine: Not So Simple!

    OpenAIRE

    DELANAYE, Pierre; Cavalier, Etienne; Pottel, Hans

    2017-01-01

    Measuring serum creatinine is cheap and commonly done in daily practice. However, interpretation of serum creatinine results is not always easy. In this review, we will briefly remind the physiological limitations of serum creatinine due notably to its tubular secretion and the influence of muscular mass or protein intake on its concentration. We mainly focus on the analytical limitations of serum creatinine, insisting on important concept such as reference intervals, standardization (and IDM...

  11. Defect engineering of SrTiO3 thin films for resistive switching applications

    International Nuclear Information System (INIS)

    Wicklein, Sebastian

    2013-01-01

    As a matter of fact, the importance of (transition) metal oxides for modern applications in the field of energy and information technology (IT) for e.g. novel energy storage systems and solid state electronic devices is increasing. Previous studies discovered the importance of defects in an oxide for their functionality and emphasized the impact of stoichiometry on the oxide performance. A new field of interest of the memory technology sector is the so-called resistive switching phenomena where a voltage stimulus causes a thin oxide (≤10 nm) to change its resistance state from a high resistance state to a low resistance state and back. So called resistive RAM (ReRAM or RRAM) are deemed to be the future replacement (2015) for contemporary FLASH memory technology due to its extremely low energy consumption, its very fast read/write time (ns) and its possible node size 3 was used as an oxide model material and was deposited by pulsed laser deposition (PLD) onto doped and undoped SrTiO 3 single crystals to investigate the formation of defects as a function of the process parameters. By combining structural and chemical thin film analysis with detailed PLD plume diagnostics and modeling of the laser plume dynamics, it was possible to elucidate the different physical mechanisms determining the stoichiometry of SrTiO 3 during PLD. Deviations between thin film and target stoichiometry are basically a result of two effects, namely, incongruent ablation and preferential scattering of lighter ablated species during their motion towards the substrate in the O 2 background gas. It is shown that the SrTiO 3 system reacts to a non-stoichiometry with the systematic incorporation of titanium and strontium vacancies which could be detected by positron annihilation lifetime spectroscopy. The role of extrinsic dopands such as Fe is shown to have more complicated effects on the SrTiO 3 system than portrayed by theoretical considerations. The effect of defects on the resistive

  12. The Human Serum Metabolome

    Science.gov (United States)

    Psychogios, Nikolaos; Hau, David D.; Peng, Jun; Guo, An Chi; Mandal, Rupasri; Bouatra, Souhaila; Sinelnikov, Igor; Krishnamurthy, Ramanarayan; Eisner, Roman; Gautam, Bijaya; Young, Nelson; Xia, Jianguo; Knox, Craig; Dong, Edison; Huang, Paul; Hollander, Zsuzsanna; Pedersen, Theresa L.; Smith, Steven R.; Bamforth, Fiona; Greiner, Russ; McManus, Bruce; Newman, John W.; Goodfriend, Theodore; Wishart, David S.

    2011-01-01

    Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite reference resources for certain clinically important biofluids, such as cerebrospinal fluid, urine and blood. As part of an ongoing effort to systematically characterize the human metabolome through the Human Metabolome Project, we have undertaken the task of characterizing the human serum metabolome. In doing so, we have combined targeted and non-targeted NMR, GC-MS and LC-MS methods with computer-aided literature mining to identify and quantify a comprehensive, if not absolutely complete, set of metabolites commonly detected and quantified (with today's technology) in the human serum metabolome. Our use of multiple metabolomics platforms and technologies allowed us to substantially enhance the level of metabolome coverage while critically assessing the relative strengths and weaknesses of these platforms or technologies. Tables containing the complete set of 4229 confirmed and highly probable human serum compounds, their concentrations, related literature references and links to their known disease associations are freely available at http://www.serummetabolome.ca. PMID:21359215

  13. B Plant process piping replacement feasibility study

    International Nuclear Information System (INIS)

    Howden, G.F.

    1996-01-01

    Reports on the feasibility of replacing existing embedded process piping with new more corrosion resistant piping between cells and between cells and a hot pipe trench of a Hanford Site style canyon facility. Provides concepts for replacement piping installation, and use of robotics to replace the use of the canyon crane as the primary means of performing/supporting facility modifications (eg, cell lining, pipe replacement, equipment reinstallation) and operational maintenenace

  14. Permanent Quadriplegia Following Replacement of Voice Prosthesis.

    Science.gov (United States)

    Ozturk, Kayhan; Erdur, Omer; Kibar, Ertugrul

    2016-11-01

    The authors presented a patient with quadriplegia caused by cervical spine abscess following voice prosthesis replacement. The authors present the first reported permanent quadriplegia patient caused by voice prosthesis replacement. The authors wanted to emphasize that life-threatening complications may be faced during the replacement of voice prosthesis. Care should be taken during the replacement of voice prosthesis and if some problems have been faced during the procedure patients must be followed closely.

  15. Strontium adsorption and penetration in kaolinite at low Sr

    NARCIS (Netherlands)

    Ning, Zigong; Ishiguro, Munehide; Koopal, Luuk K.; Sato, Tsutomu; Kashiwagi, Junichi

    2017-01-01

    Behavior of radioactive strontium (Sr2+) in contaminated soils is an important issue in relation to nuclear power plant accidents. The Sr2+ adsorption on kaolinite and its migration in a kaolinite soil were investigated because toxic effects of radioactive Sr2+ have been found to be very severe for

  16. Abscisic Acid (ABA) Regulation of Arabidopsis SR Protein Gene Expression

    Science.gov (United States)

    Cruz, Tiago M. D.; Carvalho, Raquel F.; Richardson, Dale N.; Duque, Paula

    2014-01-01

    Serine/arginine-rich (SR) proteins are major modulators of alternative splicing, a key generator of proteomic diversity and flexible means of regulating gene expression likely to be crucial in plant environmental responses. Indeed, mounting evidence implicates splicing factors in signal transduction of the abscisic acid (ABA) phytohormone, which plays pivotal roles in the response to various abiotic stresses. Using real-time RT-qPCR, we analyzed total steady-state transcript levels of the 18 SR and two SR-like genes from Arabidopsis thaliana in seedlings treated with ABA and in genetic backgrounds with altered expression of the ABA-biosynthesis ABA2 and the ABA-signaling ABI1 and ABI4 genes. We also searched for ABA-responsive cis elements in the upstream regions of the 20 genes. We found that members of the plant-specific SC35-Like (SCL) Arabidopsis SR protein subfamily are distinctively responsive to exogenous ABA, while the expression of seven SR and SR-related genes is affected by alterations in key components of the ABA pathway. Finally, despite pervasiveness of established ABA-responsive promoter elements in Arabidopsis SR and SR-like genes, their expression is likely governed by additional, yet unidentified cis-acting elements. Overall, this study pinpoints SR34, SR34b, SCL30a, SCL28, SCL33, RS40, SR45 and SR45a as promising candidates for involvement in ABA-mediated stress responses. PMID:25268622

  17. Electronic structure of Ca, Sr, and Ba under pressure.

    Science.gov (United States)

    Animalu, A. O. E.; Heine, V.; Vasvari, B.

    1967-01-01

    Electronic band structure calculations phase of Ca, Sr and Ba over wide range of atomic volumes under pressure electronic band structure calculations for fcc phase of Ca, Sr and Ba over wide range of atomic volumes under pressure electronic band structure calculations for fcc phase of Ca, Sr and Ba over wide range of atomic volumes under pressure

  18. Determination of Cs-137, Sr-89 and Sr-90 and gamma spectroscopy of water samples from the Danube River

    International Nuclear Information System (INIS)

    Tschurlovits, M.

    1980-01-01

    Radioactivity concentration of Cs-137, Sr-90, Sr-89, Co-60 and K-40 from the Danube water in the period of 1977-1979. A few systematic changes in the radioactivity concentrations were observed and presented. (author)

  19. 24 CFR 970.31 - Replacement units.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement units. 970.31 Section... PUBLIC HOUSING PROGRAM-DEMOLITION OR DISPOSITION OF PUBLIC HOUSING PROJECTS § 970.31 Replacement units. Notwithstanding any other provision of law, replacement public housing units may be built on the original public...

  20. Diagenetic replacement of Micas by Carbonates

    NARCIS (Netherlands)

    Oele, E.

    1961-01-01

    In the Ordovician sandstones of the Cantabrian Mountains a replacement of the micas by carbonate minerals could be observed. The absence of metamorphic minerals suggests a diagenetic replacement. This is supported by the finding of the same type of replacement in some undisturbed Pliocene sediments

  1. 47 CFR 13.17 - Replacement license.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Replacement license. 13.17 Section 13.17 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL RADIO OPERATORS General § 13.17 Replacement... request a replacement. The application must be accompanied by the required fee and submitted to the...

  2. 24 CFR 891.605 - Replacement reserve.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserve. 891.605... 8 Assistance § 891.605 Replacement reserve. (a) Establishment of reserve. The Borrower shall establish and maintain a replacement reserve to aid in funding extraordinary maintenance, and repair and...

  3. 24 CFR 891.745 - Replacement reserve.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserve. 891.745... and Individuals-Section 162 Assistance § 891.745 Replacement reserve. The general requirements for the replacement reserve are provided in § 891.605. For projects funded under §§ 891.655 through 891.790, the...

  4. 24 CFR 572.125 - Replacement reserves.

    Science.gov (United States)

    2010-04-01

    ...) Homeownership Program Requirements-Implementation Grants § 572.125 Replacement reserves. (a) Purpose. A single replacement reserve may be established for the homeownership program only if HUD determines it is necessary to... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Replacement reserves. 572.125...

  5. Effect of vitamin D replacement on immunological biomarkers in patients with multiple sclerosis.

    Science.gov (United States)

    Mrad, May F; El Ayoubi, Nabil K; Esmerian, Maria O; Kazan, Jalal M; Khoury, Samia J

    2017-08-01

    We aimed to investigate the immunologic effects of vitamin D replacement in RRMS patients. In a controlled single center study, patients deficient in 25-hydroxyvitamin D (serum levelvitamin D patients (serum level>35ng/ml) were followed for the same period. Assessments were performed at baseline and at 3months. 25-hydroxyvitamin D levels increased significantly from baseline to month-3 in the deficient group after treatment and remained stable in the sufficient group. We observed a decreased interferon-γ (IFNγ) secretion by CD4 + T cells in vitamin D deficient group but not in the sufficient group, and a negative correlation between baseline serum vitamin D and IFNγ production. There was no change in the frequency of T helper or regulatory T cell subsets in either group. Increasing serum levels of 25-hydroxyvitamin D are associated with decreased production of IFNγ by CD4 + T cells. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. System of Sr(NO2)2-Sr(OH)2-H2O at 25 deg C

    International Nuclear Information System (INIS)

    Popova, T.B.; Berdyukova, V.A.; Khutsistova, F.M.

    1990-01-01

    Sr(NO 2 ) 2 -Sr(OH) 2 -H 2 O system was investigated by the methods of solubility, density, viscosity, electric conductivity and refractometry. It was established that its compoments form the compound 4Sr(NO 2 ) 2 xSr(OH) 2 x8H 2 O. The compound was separated from solution; its density, decomposition temperature were determined; IR spectra and X-ray patterns of prepared and initial compounds were obtained

  7. Molecular replacement then and now

    International Nuclear Information System (INIS)

    Scapin, Giovanna

    2013-01-01

    A brief overview, with examples, of the evolution of molecular-replacement methods and models over the past few years is presented. The ‘phase problem’ in crystallography results from the inability to directly measure the phases of individual diffracted X-ray waves. While intensities are directly measured during data collection, phases must be obtained by other means. Several phasing methods are available (MIR, SAR, MAD, SAD and MR) and they all rely on the premise that phase information can be obtained if the positions of marker atoms in the unknown crystal structure are known. This paper is dedicated to the most popular phasing method, molecular replacement (MR), and represents a personal overview of the development, use and requirements of the methodology. The first description of noncrystallographic symmetry as a tool for structure determination was explained by Rossmann and Blow [Rossmann & Blow (1962 ▶), Acta Cryst.15, 24–31]. The term ‘molecular replacement’ was introduced as the name of a book in which the early papers were collected and briefly reviewed [Rossmann (1972 ▶), The Molecular Replacement Method. New York: Gordon & Breach]. Several programs have evolved from the original concept to allow faster and more sophisticated searches, including six-dimensional searches and brute-force approaches. While careful selection of the resolution range for the search and the quality of the data will greatly influence the outcome, the correct choice of the search model is probably still the main criterion to guarantee success in solving a structure using MR. Two of the main parameters used to define the ‘best’ search model are sequence identity (25% or more) and structural similarity. Another parameter that may often be undervalued is the quality of the probe: there is clearly a relationship between the quality and the correctness of the chosen probe and its usefulness as a search model. Efforts should be made by all structural biologists to

  8. Using 87Sr/86Sr ratios to investigate changes in stream chemistry during snowmelt in the Provo River, Utah, USA

    Science.gov (United States)

    Hale, C. A.; Carling, G. T.; Fernandez, D. P.; Nelson, S.; Aanderud, Z.; Tingey, D. G.; Dastrup, D.

    2017-12-01

    Water chemistry in mountain streams is variable during spring snowmelt as shallow groundwater flow paths are activated in the watershed, introducing solutes derived from soil water. Sr isotopes and other tracers can be used to differentiate waters that have interacted with soils and dust (shallow groundwater) and bedrock (deep groundwater). To investigate processes controlling water chemistry during snowmelt, we analyzed 87Sr/86Sr ratios, Sr and other trace element concentrations in bulk snowpack, dust, soil, soil water, ephemeral channels, and river water during snowmelt runoff in the upper Provo River watershed in northern Utah, USA, over four years (2014-2017). Strontium concentrations in the river averaged 20 ppb during base flow and decreased to 10 ppb during snowmelt runoff. 87Sr/86Sr ratios were around 0.717 during base flow and decreased to 0.715 in 2014 and 0.713 in 2015 and 2016 during snowmelt, trending towards less radiogenic values of mineral dust inputs in the Uinta Mountain soils. Ephemeral channels, representing shallow flow paths with soil water inputs, had Sr concentrations between 7-20 ppb and 87Sr/86Sr ratios between 0.713-0.716. Snowpack Sr concentrations were generally soils that contain accumulated dust deposits with a less radiogenic 87Sr/86Sr ratio. These results suggest that flow paths and atmospheric dust are important to consider when investigating variable solute loads in mountain streams.

  9. The epidemiology of serum sex hormones in postmenopausal women

    International Nuclear Information System (INIS)

    Cauley, J.A.; Kuller, L.H.; LeDonne, D.; Gutai, J.P.; Powell, J.G.

    1989-01-01

    Serum sex hormones may be related to the risk of several diseases including osteoporosis, heart disease, and breast and endometrial cancer in postmenopausal women. In the current report, the authors examined the epidemiology of serum sex hormones in 176 healthy, white postmenopausal women (mean age 58 years) recruited from the metropolitan Pittsburgh, Pennsylvania, area. The data were collected during 1982-1983; none of the women were on estrogen replacement therapy. Serum concentrations of estrone, estradiol, testosterone, and androstenedione were measured by a combination of extraction, column chromatography, and radioimmunoassay. Neither age nor time since menopause was a significant predictor of sex hormones. The degree of obesity was a major determinant of estrone and estradiol. The estrone levels of obese women were about 40% higher than the levels of nonobese women. There was a weak relation between obesity and the androgens. Cigarette smokers had significantly higher levels of androstenedione than nonsmokers, with little difference in serum estrogens between smokers and nonsmokers. Both estrone and estradiol levels tended to decline with increasing alcohol consumption. Physical activity was an independent predictor of serum estrone. More active women had lower levels of estrone. There was a positive relation of muscle strength with estrogen levels. The data suggest interesting relations between environmental and lifestyle factors and serum sex hormones. These environmental and lifestyle factors are potentially modifiable and, hence, if associations between sex hormones and disease exist, modification of these factors could affect disease risks

  10. The epidemiology of serum sex hormones in postmenopausal women

    Energy Technology Data Exchange (ETDEWEB)

    Cauley, J.A.; Kuller, L.H.; LeDonne, D. (Univ. of Pittsburgh, PA (USA)); Gutai, J.P. (Wayne State Univ., Detroit, MI (USA)); Powell, J.G. (East Carolina School of Medicine, Greenville, NC (USA))

    1989-06-01

    Serum sex hormones may be related to the risk of several diseases including osteoporosis, heart disease, and breast and endometrial cancer in postmenopausal women. In the current report, the authors examined the epidemiology of serum sex hormones in 176 healthy, white postmenopausal women (mean age 58 years) recruited from the metropolitan Pittsburgh, Pennsylvania, area. The data were collected during 1982-1983; none of the women were on estrogen replacement therapy. Serum concentrations of estrone, estradiol, testosterone, and androstenedione were measured by a combination of extraction, column chromatography, and radioimmunoassay. Neither age nor time since menopause was a significant predictor of sex hormones. The degree of obesity was a major determinant of estrone and estradiol. The estrone levels of obese women were about 40% higher than the levels of nonobese women. There was a weak relation between obesity and the androgens. Cigarette smokers had significantly higher levels of androstenedione than nonsmokers, with little difference in serum estrogens between smokers and nonsmokers. Both estrone and estradiol levels tended to decline with increasing alcohol consumption. Physical activity was an independent predictor of serum estrone. More active women had lower levels of estrone. There was a positive relation of muscle strength with estrogen levels. The data suggest interesting relations between environmental and lifestyle factors and serum sex hormones. These environmental and lifestyle factors are potentially modifiable and, hence, if associations between sex hormones and disease exist, modification of these factors could affect disease risks.

  11. Half metallic ferromagnetism in tri-layered perovskites Sr{sub 4}T{sub 3}O{sub 10}(T = Co, Rh)

    Energy Technology Data Exchange (ETDEWEB)

    Ghimire, Madhav Prasad, E-mail: ghimire.mpg@gmail.com [Faculty of Science, Nepal Academy of Science and Technology, P. O. Box 3323, Khumaltar, Lalitpur (Nepal); International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science, Tsukuba 305-0044 (Japan); Thapa, R. K.; Sandeep [Department of Physics, Mizoram University, Aizawl 796-004 (India); Rai, D. P. [Department of Physics, Pachhunga University College, Aizawl 796-001 (India); Sinha, T. P. [Department of Physics, Bose Institute, Kolkata 700-009 (India); Hu, Xiao [International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science, Tsukuba 305-0044 (Japan)

    2015-02-14

    First-principles density functional theory (DFT) is used to investigate the electronic and magnetic properties of Sr{sub 4}Rh{sub 3}O{sub 10}, a member of the Ruddlesden-Popper series. Based on the DFT calculations taking into account the co-operative effect of Coulomb interaction (U) and spin-orbit couplings (SOC), Sr{sub 4}Rh{sub 3}O{sub 10} is found to be a half metallic ferromagnet (HMF) with total magnetic moment μ{sub tot} = 12 μ{sub B} per unit cell. The material has almost 100% spin-polarization at the Fermi level despite of sizable SOC. Replacement of Rh atom by the isovalent Co atom is considered. Upon full-replacement of Co, a low-spin to intermediate spin transition happens resulting in a HMF state with the total magnetic moment three-time larger (i.e., μ{sub tot} = 36 μ{sub B} per unit cell), compared to Sr{sub 4}Rh{sub 3}O{sub 10}. We propose Sr{sub 4}Rh{sub 3}O{sub 10} and Sr{sub 4}Co{sub 3}O{sub 10} as candidates of half metals.

  12. Controversies in hormone replacement therapy

    Directory of Open Access Journals (Sweden)

    A. Baziad

    2001-09-01

    Full Text Available Deficiency of estrogen hormone will result in either long-term or short-term health problems which may reduce the quality of life. There are numerous methods by which the quality of female life can be achieved. Since the problems occuring are due to the deficiency of estrogen hormone, the appropriate method to tackle the problem is by administration of estrogen hormone. The administration of hormone replacement therapy (HRT with estrogen may eliminate climacteric complaints, prevent osteoporosis, coronary heart disease, dementia, and colon cancer. Although HRT has a great deal of advantage, its use is still low and may result in controversies. These controversies are due to fact that both doctor and patient still hold on to the old, outmoded views which are not supported by numerous studies. Currently, the use of HRT is not only based on experience, or temporary observation, but more on evidence based medicine. (Med J Indones 2001; 10: 182-6Keywords: controversies, HRT

  13. Tracheal replacement by autogenous aorta

    Directory of Open Access Journals (Sweden)

    Anoosh Farhad

    2009-06-01

    Full Text Available Abstract Background Tracheal defects may occur after trauma or prolonged intubation. Resection of tracheal tumors also poses a major challenge for substitution. In an effort to solve this problem, different techniques have been tried with little success. We report on a new animal model which showed acceptable results with fewer complications. Methods We replaced 5 cm of cervical trachea in 10 dogs with harvested infra-renal aorta and repaired the aortic defect with Dacron graft. Results Necropsy of the grafted aorta and anastomotic site revealed well healed anastomosis in all animals together with ciliated columnar epithelium coverage of grafted aorta and neovascularization of aortic wall. Conclusion Aortic graft is preferable to other substitutes because of less antigenicity, less vascularity, and no mucous secretions or peristalsis

  14. Tracheal replacement by autogenous aorta.

    Science.gov (United States)

    Anoosh, Farhad; Hodjati, Hossain; Dehghani, Seifollah; Tanideh, Nader; Kumar, Perikala V

    2009-06-09

    Tracheal defects may occur after trauma or prolonged intubation. Resection of tracheal tumors also poses a major challenge for substitution. In an effort to solve this problem, different techniques have been tried with little success. We report on a new animal model which showed acceptable results with fewer complications. We replaced 5 cm of cervical trachea in 10 dogs with harvested infra-renal aorta and repaired the aortic defect with Dacron graft. Necropsy of the grafted aorta and anastomotic site revealed well healed anastomosis in all animals together with ciliated columnar epithelium coverage of grafted aorta and neovascularization of aortic wall. Aortic graft is preferable to other substitutes because of less antigenicity, less vascularity, and no mucous secretions or peristalsis.

  15. Renal replacement therapy in Europe

    DEFF Research Database (Denmark)

    Pippias, Maria; Stel, Vianda S; Abad Diez, José Maria

    2015-01-01

    BACKGROUND: This article summarizes the 2012 European Renal Association-European Dialysis and Transplant Association Registry Annual Report (available at www.era-edta-reg.org) with a specific focus on older patients (defined as ≥65 years). METHODS: Data provided by 45 national or regional renal...... disease (ESRD) receiving renal replacement therapy (RRT) and renal transplantation rates for 2012 are presented. RESULTS: In 2012, the overall unadjusted incidence rate of patients with ESRD receiving RRT was 109.6 per million population (pmp) (n = 69 035), ranging from 219.9 pmp in Portugal to 24.2 pmp...... to 32% between countries. The overall renal transplantation rate in 2012 was 28.3 pmp (n = 15 673), with the highest rate seen in the Spanish region of Catalonia. The proportion of patients ≥65 years receiving a transplant ranged from 0 to 35%. Five-year adjusted survival for all RRT patients was 59...

  16. Computer simulation of replacement sequences in copper

    International Nuclear Information System (INIS)

    Schiffgens, J.O.; Schwartz, D.W.; Ariyasu, R.G.; Cascadden, S.E.

    1978-01-01

    Results of computer simulations of , , and replacement sequences in copper are presented, including displacement thresholds, focusing energies, energy losses per replacement, and replacement sequence lengths. These parameters are tabulated for six interatomic potentials and shown to vary in a systematic way with potential stiffness and range. Comparisons of results from calculations made with ADDES, a quasi-dynamical code, and COMENT, a dynamical code, show excellent agreement, demonstrating that the former can be calibrated and used satisfactorily in the analysis of low energy displacement cascades. Upper limits on , , and replacement sequences were found to be approximately 10, approximately 30, and approximately 14 replacements, respectively. (author)

  17. Transport of Sr 2+ and SrEDTA 2- in partially-saturated and heterogeneous sediments

    Science.gov (United States)

    Pace, M. N.; Mayes, M. A.; Jardine, P. M.; McKay, L. D.; Yin, X. L.; Mehlhorn, T. L.; Liu, Q.; Gürleyük, H.

    2007-05-01

    Strontium-90 has migrated deep into the unsaturated subsurface beneath leaking storage tanks in the Waste Management Areas (WMA) at the U.S. Department of Energy's (DOE) Hanford Reservation. Faster than expected transport of contaminants in the vadose zone is typically attributed to either physical hydrologic processes such as development of preferential flow pathways, or to geochemical processes such as the formation of stable, anionic complexes with organic chelates, e.g., ethylenediaminetetraacetic acid (EDTA). The goal of this paper is to determine whether hydrological processes in the Hanford sediments can influence the geochemistry of the system and hence control transport of Sr 2+ and SrEDTA 2-. The study used batch isotherms, saturated packed column experiments, and an unsaturated transport experiment in an undisturbed core. Isotherms and repacked column experiments suggested that the SrEDTA 2- complex was unstable in the presence of Hanford sediments, resulting in dissociation and transport of Sr 2+ as a divalent cation. A decrease in sorption with increasing solid:solution ratio for Sr 2+ and SrEDTA 2- suggested mineral dissolution resulted in competition for sorption sites and the formation of stable aqueous complexes. This was confirmed by detection of MgEDTA 2-, MnEDTA 2-, PbEDTA 2-, and unidentified Sr and Ca complexes. Displacement of Sr 2+ through a partially-saturated undisturbed core resulted in less retardation and more irreversible sorption than was observed in the saturated repacked columns, and model results suggested a significant reservoir (49%) of immobile water was present during transport through the heterogeneous layered sediments. The undisturbed core was subsequently disassembled along distinct bedding planes and subjected to sequential extractions. Strontium was unequally distributed between carbonates (49%), ion exchange sites (37%), and the oxide (14%) fraction. An inverse relationship between mass wetness and Sr suggested that

  18. Cost justification of chiller replacement

    International Nuclear Information System (INIS)

    Baker, T.J.; Baumer, R.A.

    1993-01-01

    We often hear of products with paybacks that are too good to be true. Just a few weeks ago,a client received a recommendation from a national service company's local office. In the letter the company recommended that open-quotes due to the age and condition of the boiler ... that the school consider replacing the boiler... The cost for the new boiler can usually be recovered by lower fuel bills in 2 to 3 yearsclose quotes. This was for an installation in Southeast Texas where the boiler is only used 4 to 5 months per year. Analysis show the above claims to be nonsense. A new boiler would cost about $47,000 installed. Current total gas bills for the facility are $15,630 per year. They would have to shutoff the gas to the facility to have a three year payback. In fact, only two-thirds of the gas is used to heat the facility so we have only $10, 000 to write off against the new boiler. How much will the greater efficiency save? A 30% savings due to greater efficiency produces $3,000 per year in gas savings to offset the $47,000 cost, a 16 year payback. And much of the efficiency savings can be realized by adjusting the existing boiler. In another care a client wanted to investigate replacement of a twenty year old chiller plant with more efficient equipment. We investigated the project and determined that the payback would be greater than ten years. They did not operate the equipment during the summer and at less than 50% of capacity the balance of the year

  19. Systematic variations of 87Sr/56Sr ratios, Sr compositions, selected major-oxide concentrations, and mineral abundances in piston cores from the Red Sea

    International Nuclear Information System (INIS)

    Boger, P.D.; Boger, J.L.; Faure, G.

    1980-01-01

    A mixing model is presented which relates the concentrations of Sr to the 87 Sr/ 86 Sr ratios and concentrations of other elements contained in a mixture of two components. The model is applied to the measured 87 Sr/ 86 Sr ratios, Sr, CaO, Fe 2 O 3 and SiO 2 concentrations of the detrital fractions of sediment from three piston cores representing different depositional environments in the Red Sea. The sediment is shown to be a mixture of two components derived from old sialic rocks and young volcanic rocks of the surrounding land masses. One of the cores contained a third component which is identified as authigenic Fe 2 O 3 . Removal of this contaminant is shown to return the system to its original detrital constituents. (Auth.)

  20. A method for determination of 90Sr in vegetation

    International Nuclear Information System (INIS)

    Nygren, U.

    1998-12-01

    This report describes a method for determination of 90 Sr in vegetation. The method consists of wet-ashing the samples and separating Sr from the sample matrix by oxalate precipitation and extraction chromatography. 90 Y ingrowth is awaited after which Y is separated from Sr and 90 Y measured in a proportional counter. The method has been applied on two reference materials and the 90 Sr results agree well with the recommended values. The method has also been used on 20 samples of blueberry twigs and the mean recovery of Sr was 74%

  1. Rb-Sr ages and initial 87Sr/86Sr ratios of late paleozoic granitic rocks from northern Chile

    International Nuclear Information System (INIS)

    Shibata, Ken; Ishihara, Shunso; Ulriksen, C.E.

    1984-01-01

    Rb-Sr whole-rock isochron ages were determined on three suites of so-called Paleozoic granitic rocks from northern coastal Chile. The granitic rocks from the Valparaiso and Ci Funcho areas are dated as 296.3 +- 5.4 Ma and 262.2 +- 4.6 Ma, respectively, which are in accord with geologically estimated age. The rocks from the Chanaral area is dated as 212.8 +- 8.6 Ma, which is correlated close to the Triassic-Jurassic boundary age. A K-Ar age of 196 +- 6 Ma was obtained on biotite in granite from Esmeralda between Ci Funcho and Chanaral. These age results demonstrate that no Precambrian plutonism occurred in the studied area, and that so-called Paleozoic granitic rocks in the Ci Funcho-Chanaral area are divided into Permian and early Mesozoic in age. Initial 87 Sr/ 86 Sr ratios of the ilmenite-series granitic rocks from the coastal region are 0.70641 (Valparaiso), 0.70635 (Ci Funcho) and 0.70455 (Chanaral). These relatively low ratios deny substantial crustal contribution to the granitoids. The initial ratios of magnetite-series granitoids from porphyry- and manto-type mineralized areas (Chiquicamata, El Salvador and Tocopilla) are as low as 0.70344 to 0.70464. (author)

  2. Optimization on replacement period of plant equipment

    International Nuclear Information System (INIS)

    Kasai, Masao; Asano, Hiromi

    2002-01-01

    Optimization of the replacement period of plant equipment is one of the main items to rationalize the activities on plant maintenance. There are several models to replace the equipment and the formulations for optimizing the replacement period are different among these models. In this study, we calculated the optimum replacement periods for some equipment parts based on the replacement models and found that the optimum solutions are not so largely differ from the replacement models as far as the replacement period is not so large. So we will be able to use the most usable model especially in the early phase of rationalization on plant maintenance, since there are large uncertainties in data for optimization. (author)

  3. Sr - an element shows the way - Applications of Sr isotopes for provenance, tracing and migration (Invited)

    Science.gov (United States)

    Prohaska, T.; Irrgeher, J.; Zitek, A.; Teschler Nicola, M.

    2010-12-01

    Strontium - named after the small Scottish town Strontian - as such is an element with little popularity. Firstly described by Martin Heinrich Klaproth in 1798, the metal is used in metallurgy to some extent whereas its compounds are interesting in glass industries, electronics and pyrotechnics. The element has chemical similarity to Ca and makes up 1/60 of the earth’s amount of the latter. Nonetheless, it is its isotopic composition which makes Sr so interesting for a large number of scientists. The natural composition of the four naturally occurring isotopes (84Sr, 86Sr 87Sr and 88Sr) varies in nature due to the radioactive decay of 87Rb to 87Sr. Thus, it was early recognized as geochronometer especially in Ca rich matrices. With increasing precision of applied methodology, the natural variation of the 87Sr/86Sr isotope ratio (analyzed at first mainly by thermal ionization mass spectrometry (TIMS)) became more and more popular in provenance studies. The natural variation of the ratio is mainly determined by the geological age and the original composition of the rock and can be used therefore as fingerprint of the local geology. The ratio is transferred with no significant fractionation via the water into plants and finally via the food chain into animal and human tissues (especially bones and teeth). As the element is chemically similar to Ca, it appears in most matrices. The use for provenance studies is supported by the fact that the long half life (4.8 x 1010 years) does not lead to an alteration during the time scales which are investigated (from recent samples to human or animal skeletal remains which date back up to 30.000 BC). The uniqueness of the system besides the natural variation is defined by the ubiquity in nature and the relatively high (and thus measurable) elemental concentration in most tissues. It was finally the advent of multiple collector inductively coupled plasma mass spectrometry (MC-ICP-MS) which augmented the number of applications

  4. Determination of /sup 90/Sr in milk by solvent extraction of /sup 90/Y

    Energy Technology Data Exchange (ETDEWEB)

    Mitsuhashi, T [National Inst. of Animal Industry, Chiba (Japan); Sakanoue, M

    1977-10-01

    In order to replace the conventional method using violent fuming nitric acid, a new method for the determination of /sup 90/Sr in milk has been developed by using the solvent extraction with bis (2-ethylhexyl) phosphoric acid (HDEHP). The daughter nuclide /sup 90/Y in a radiochemical equilibrium with its parent /sup 90/Sr was extracted with 2:1 HDEHP-toluene from the acid solution (1M HCl) of milk ash sample prepared by dry-ashing. After stripping with 8M HCl, /sup 90/Y, together with stable yttrium added as carrier, was precipitated as oxalate to prepare ..beta..-counting source. The radiochemical purity was confirmed by decay curve. The decontamination of strontium was checked by applying non-dispersive fluorescence x-ray analysis using /sup 133/Ba as irradiating source. Bone samples of cow were also analyzed by the same method and the results were compared with those obtained by other methods. The duplicate crosschecking analyses of finely ground bone samples were carried out to examine the effectiveness of this method. This simple new method was found to be very effective for the routine analysis of /sup 90/Sr in these samples.

  5. Determination of 90Sr in milk by solvent extraction of 90Y

    International Nuclear Information System (INIS)

    Mitsuhashi, Toshihiko; Sakanoue, Masanobu.

    1977-01-01

    In order to replace the conventional method using violent fuming nitric acid, a new method for the determination of 90 Sr in milk has been developed by using the solvent extraction with bis (2-ethylhexyl) phosphoric acid (HDEHP). The daughter nuclide 90 Y in a radiochemical equilibrium with its parent 90 Sr was extracted with 2:1 HDEHP-toluene from the acid solution (1M HCl) of milk ash sample prepared by dry-ashing. After stripping with 8M HCl, 90 Y, together with stable yttrium added as carrier, was precipitated as oxalate to prepare β-counting source. The radiochemical purity was confirmed by decay curve. The decontamination of strontium was checked by applying non-dispersive fluorescence x-ray analysis using 133 Ba as irradiating source. Bone samples of cow were also analyzed by the same method and the results were compared with those obtained by other methods. The duplicate crosschecking analyses of finely ground bone samples were carried out to examine the effectiveness of this method. This simple new method was found to be very effective for the routine analysis of 90 Sr in these samples. (auth.)

  6. Magnetoelastic coupling in Sr2(Fe1-xCrx)ReO6 double perovskites

    International Nuclear Information System (INIS)

    Serrate, D; Teresa, J M De; Algarabel, P A; Marquina, C; Blasco, J; Ibarra, M R; Galibert, J

    2007-01-01

    We have investigated magnetoelastic coupling in Sr 2 (Fe 1-x Cr x )ReO 6 polycrystalline double perovskites. The end compound, Sr 2 CrReO 6 , shows a high ferromagnetic transition temperature of 635 K and is thought to exhibit a nearly half-metallic conduction band. We probed the unexpected high orbital moment borne by the Re atom by means of volume and anisotropic magnetostriction measurements in magnetic fields up to 12 T. Our magnetostriction results can be explained by the existence of a large spin-orbit coupling which, in combination with crystal-field effects, produces a single-ion type magnetostrictive response. The Re orbital moment triggers a greatly enhanced magnetocrystalline anisotropy compared to other ferromagnetic double perovskites. From our magnetostriction data, the temperature dependence of the coercive field as a function of Cr-doping is obtained. We discovered that the coercive field increases as Fe is replaced with Cr, which is linked to a strong enhancement of the magnetic anisotropy. This suggests a close relationship between the Fe[Cr]-O-Re coupling and the magnetic anisotropy. We also analysed the impact of the Re orbital moment on the spin-dependent transport across Sr 2 CrReO 6 grain boundaries. The present work opens up the possible use of these compounds for magnetostrictive applications in a wide temperature and magnetic field range

  7. Sr isotopic tracer study of the Samail ophiolite, Oman

    International Nuclear Information System (INIS)

    Lanphere, M.A.; Coleman, R.G.; Hopson, C.A.

    1981-01-01

    We have measured Rb and Sr concentrations and Sr isotopic compositions in 41 whole-rock samples and 12 mineral separates from units of the Samail ophiolite, including peridotite, gabbro, plagiogranite diabase dikes, and gabbro and websterite dikes within the metamorphic peridotite. Ten samples of cummulate gabbro from the Wadir Kadir section and nine samples from the Wadi Khafifah section have mean 87 Sr/ 86 Sr ratios and standard deviations of 0.70314 +- 0.00030 and 0.70306 +- 0.00034, respectively. The dispersion in Sr isotopic composition may reflect real heterogeneities in the magma source region. The average Sr isotopic composition of cumulate gabbro falls in the range of isotopic compositions of modern midocean ridge basalt. The 87 Sr/ 86 Sr ratios of noncumulate gabbro, plagiogranite, and diabase dikes range from 0.7034 to 0.7047, 0.7038 to 0.7046, and 0.7037 to 0.7061, respectively. These higher 87 Sr/ 86 Sr ratios are due to alteration of initial magmatic compositions by hydrothermal exchange with seawater. Mineral separates from dikes that cut harzburgite tectonite have Sr isotopic compositions which agree with that of cumulate gabbro. These data indicate that the cumulate gabbro and the different dikes were derived from partial melting of source regions that had similar long-term histories and chemical compositions

  8. The influence of Sr content in calcium phosphate coatings

    International Nuclear Information System (INIS)

    Lindahl, Carl; Pujari-Palmer, Shiuli; Hoess, Andreas; Ott, Marjam; Engqvist, Håkan; Xia, Wei

    2015-01-01

    In this study calcium phosphate coatings with different amounts of strontium (Sr) were prepared using a biomineralization method. The incorporation of Sr changed the composition and morphology of coatings from plate-like to sphere-like morphology. Dissolution testing indicated that the solubility of the coatings increased with increased Sr concentration. Evaluation of extracts (with Sr concentrations ranging from 0 to 2.37 μg/mL) from the HA, 0.06Sr, 0.6Sr, and 1.2Sr coatings during in vitro cell cultures showed that Sr incorporation into coatings significantly enhanced the ALP activity in comparison to cells treated with control and HA eluted media. These findings show that calcium phosphate coatings could promote osteogenic differentiation even in a low amount of strontium. - Highlights: • Calcium phosphate coating doping with low Sr contents was prepared via a biomineralization process. • The solubility of the coatings increased with increased Sr concentration. • Present findings show the potential that Sr has on promoting osteogenic differentiation even in a low amount

  9. 87Sr/86Sr isotope fingerprinting of Scottish and Icelandic migratory shorebirds

    International Nuclear Information System (INIS)

    Evans, Jane; Bullman, Rhys

    2009-01-01

    Biosphere Sr isotope composition data from Iceland and Scotland suggest that terrestrially feeding birds from these two countries will have significantly different 87 Sr/ 86 Sr isotope composition in their tissues. The aim of this study is to test if these differences can be measured within the bone and feather of migratory wading birds, who feed terrestrially as juveniles, thus providing a provenance tool for these birds. The study shows that birds can be distinguished on the basis of the Sr isotope composition of their bone. The field for Icelandic birds is defined by data from juvenile common redshank (Tringa totanus) and whimbrel (Numenius phaeopus) which give 0.7056 ± 0.0012, (2σ, n = 7). The majority of Scottish birds in this study are from coastal regions and have a signature close to that of seawater of 0.7095 ± 0.0006 (2σ, n = 9). The Sr ratios in the body tissue of these two populations of all Icelandic and Scottish adult and juvenile birds analysed are significantly different (p 87 Sr/ 86 Sr values as high as 0.7194 which reflect their non-marine diet. Icelandic redshank (Tringa totanus robusta) that have flown to Scotland and returned to Iceland show the effect of the Scottish contribution to their diet with elevated values of 0.7086 ± 0.0004, (2σ, n = 6). Redshank found in Scotland that cannot be classified on the basis biometric analysis are shown to be of Icelandic origin and analysis of the primary feathers from two birds demonstrates that isotope variation between feathers could be used to track changes in diet related to the timing of individual feather growth.

  10. Experimental autoabsorption curve 90Sr in SrCO3. Efficiency calculation to detection of 90Sr, 90Y and 90Sr + 90Y in a beta gas proportional counter

    International Nuclear Information System (INIS)

    Gasco, C.; Alvarez, A.

    1987-01-01

    Strontium-90 has been determined by radiochemical separation techniques in environmental samples. These techniques, of course, cannot separate the two strontium radionuclides from each other of from stable strontium. Consequently the end product of the chemical separation contains all strontium isotopes in SrCO 3 . The beta particules emitted by 90 Sr are absorbed by the SrCO 3 precipitate. This is the main source of error in the activity measurement. It has been prepared sources of 90 Sr in SrCO 3 in order to determinate the counting efficiency and autoabsorption curve. Also detection efficiencies have been calibrated using known activities of 90 Y and equilibrium mixture of 90 Sr+ 90 Y in the same geometry than our samples. The activity of 90 Sr by ingrowth of 90 Y has been calculated by our computer program. (author). 2 figs., 3 refs

  11. Test for the determination of 90Sr in soil

    International Nuclear Information System (INIS)

    1980-01-01

    The standardized method is based on the chemical separation (extraction, precipitation, etc.) of 90 Sr from other fission products. After long-term storage for 90 Sr- 90 Y equilibrium the activity of the sample precipitated in the form of Y(COO) 2 is measured. The Sr yield coefficient is determined by 85 Sr tracer or by gravimetry. The test is applicable for the determination of 90 Sr contamination originating from fallout or from other sources in soil, when the concentration of 90 Sr is higher than 0.2-0.4 Bqg -1 (5-10 pCig -1 ). The error of the method is less than +-2% of the amount of the 90 Sr present. (Sz.J.)

  12. Free serum thyroxine

    International Nuclear Information System (INIS)

    Degrossi, O.J.; Altschuler, Noe; Cabrejas, M.L. de; Pinkas, Mirta; Garcia del Rio, Hernan

    1982-01-01

    The use of radiommunoassay (RIA) tehcniques has increased the diagnosis of thyroid functional alterations. A solid phase RIA method for free thyroxine (FT4) measurement was tested. Serum FT4, Total T4, T3 and TSH were determined by radioimmunoassay in 179 subjects. One hundred twenty two patients were normal (8 to 75 years old); FT4 was 1.42 +- 0.03 ng/100 ml (avg. value and std. error). In 27 cases of thyrotoxicosis the values were 4.66 +- 0.48 ng/100 ml and in 15 cases of hypothyroidism 0.50 +- 0.06 ng/100 ml (statistics probability [es

  13. Tuning electronic structure and optical properties of SrTiO{sub 3} by site-specific doping by Nb with N/B from hybrid functional calculations

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Yanyu; Zhou, Wei; Wu, Ping, E-mail: pingwu@tju.edu.cn

    2017-07-01

    In this study, the extensive density functional theory calculations are performed to modify the electronic structure of perovskite SrTiO{sub 3} by doping with Nb and N/B. The unoccupied states induced by the Nb monodoping at the Sr or Ti site, which were passivated in the codoped systems (the substitution of Nb at Ti site with the replacement of N at O site: Nb@Ti/N@O and the substitution of Nb at Sr site with the replacement of B at O site: Nb@Sr/B@O). The charge-compensated donor-acceptor pair codoping creates the new occupied states within the band gap, which yields the absorption edge extend to visible light. And the calculated defect formation energy implies that the codoped systems are energetically favorable under the O-rich condition. Moreover, the band-edge alignment confirmed that the Nb@Ti/N@O system is desirable for the spontaneous water splitting under visible light and the Nb@Sr/B@O system can split water into hydrogen in presence of sacrificial agent. - Highlights: • A systematical study has been employed on SrTiO{sub 3} with the donor-acceptor codoping. • The donor-acceptor pair codoping yields the absorption edge extend to visible light. • The formation energy implies that the codoped systems are favorable under the O-rich condition. • The Nb@Ti/N@O system is desirable for the spontaneous water splitting under visible light. • The Nb@Sr/B@O system can split water into hydrogen in presence of sacrificial agent.

  14. High-spin states in 82Sr

    International Nuclear Information System (INIS)

    Baktash, C.; Halper, M.L.; Garcia Bermudez, G.J.

    1989-01-01

    As recent theoretical calculations that predicted the onset of superdeformation in the A ≅ 80 region, the 52 Cr( 34 S,2p2n) reaction at 130 MeV beam energy was employed to populate the high-spin states in 82 Sr. The detection system consisted of the ORNL Compton-Suppression Spectrometer System (18 Ge detectors), the Spin Spectrometer, and the 4 φ CsI Dwarf Ball of Washington University. Off-line analysis of the proton-gated data resulted in nearly 170 million Ge-Ge pairs, which were mostly due to the 2p2n channel. A decay scheme extending to spin I=27h has been established. No strong evidence for the presence of superdeformed states in 82 Sr was found in a preliminary analysis of the data. (Author) [es

  15. Energy consumption in smelting reduction (SR) processes

    International Nuclear Information System (INIS)

    Assis, Paulo Santos; Salierno, Giovanni Felice; Fang, Jue; Mankhand, Tilak R.; Assis, Carlos Frederico Campos de

    2010-01-01

    In contrast, conventional processes use coke and hematite/sinter in the blast furnace, in SR processes, other alternative fuels and iron ore sources, like charcoal and fine iron ores, can be used to produce sponge iron. The use of these alternative sources, by SR processes, can reduce environmental impacts and lower production costs. At first, the concepts of the theoretical gas utilization ratio, the smelting heat of the iron ore and the effective calorific value of coal were introduced. Then, the reason for gas utilization ratio and its performance in the shaft as a reducer in the smelting process are discussed and calculated. The relationship between coal consumption and iron ore reduction in the fluidized bed are also discussed. Finally, the influence of post-combustion on coal consumption in an iron bath furnace are calculated and discussed. (author)

  16. Steroid replacement in primary adrenal failure does not appear to affect circulating adipokines.

    Science.gov (United States)

    Fichna, Marta; Fichna, Piotr; Gryczyńska, Maria; Czarnywojtek, Agata; Żurawek, Magdalena; Ruchała, Marek

    2015-03-01

    Despite continuous efforts for an optimal steroid replacement, recent observations suggest increased cardiometabolic risk and related mortality in primary adrenal insufficiency (PAI). Adipokines are peptides from the adipose tissue, markers of cardiometabolic dysfunction. This study was aimed to evaluate serum levels of adipokines: leptin, adiponectin, and resistin in PAI during conventional steroid substitution. The analysis comprised 63 patients (mean age 42.7 ± 14.1 years) and 63 healthy controls. Serum adipokines, lipid profile, and plasma glucose were assessed in both cohorts. ACTH, serum insulin, HOMA-IR, DHEA-S, cortisol and 24 h urinary free cortisol were determined in PAI. Body mass composition was analyzed by Dual-Energy X-ray Absorptiometry. Mean BMI in the control group was 24.1 ± 3.9 kg/m(2) and 23.7 ± 3.9 kg/m(2) in the PAI cohort. Serum leptin and adiponectin levels were similar in both groups, whereas resistin appeared significantly lower among affected subjects (p = 0.0002). Its levels were weakly correlated with HOMA-IR (p = 0.048). Leptin was independently correlated with fasting insulin, HOMA-IR, BMI, and body fat (p regression analysis only weight (p = 0.017), total and HDL cholesterol (p replacement. Serum adipokines in treated PAI follow similar correlations to those reported in healthy subjects. Further prospective studies are warranted to verify and explain plausible excess of cardiovascular mortality in PAI.

  17. Phenotypical and functional characteristics of mesenchymal stem cells from bone marrow: comparison of culture using different media supplemented with human platelet lysate or fetal bovine serum

    Science.gov (United States)

    2012-01-01

    Introduction Mesenchymal stem cells (MSCs) are multipotent cells able to differentiate into several mesenchymal lineages, classically derived from bone marrow (BM) but potentially from umbilical cord blood (UCB). Although they are becoming a good tool for regenerative medicine, they usually need to be expanded in fetal bovine serum (FBS)-supplemented media. Human platelet lysate (HPL) has recently been proposed as substitute for safety reasons, but it is not yet clear how this supplement influences the properties of expanded MSCs. Methods In the present study, we compared the effect of various media combining autologous HPL with or without FBS on phenotypic, proliferative and functional (differentiation, cytokine secretion profile) characteristics of human BM-derived MSCs. Results Despite less expression of adipogenic and osteogenic markers, MSCs cultured in HPL-supplemented media fully differentiated along osteoblastic, adipogenic, chondrogenic and vascular smooth muscle lineages. The analyses of particular specific proteins expressed during osteogenic differentiation (calcium-sensing receptor (CaSR) and parathormone receptor (PTHR)) showed their decrease at D0 before any induction for MSC cultured with HPL mostly at high percentage (10%HPL). The cytokine dosage showed a clear increase of proliferation capacity and interleukin (IL)-6 and IL-8 secretion. Conclusions This study shows that MSCs can be expanded in media supplemented with HPL that can totally replace FBS. HPL-supplemented media not only preserves their phenotype as well as their differentiation capacity, but also shortens culture time by increasing their growth rate. PMID:22333342

  18. 87Sr/86Sr ratios in permo-carboniferous sea water from the analyses of well-preserved brachiopod shells

    International Nuclear Information System (INIS)

    Popp, B.N.; Anderson, T.F.

    1986-01-01

    Sr isotopic analyses of well-preserved portions of Permo-Carboniferous brachiopods distributed globally confirm the general shape of the Sr isotope age curve established by previous workers for this time interval. There is little variation between the SR isotopic composition of unaltered portions of brachiopods and that of portions of the same shell interpreted to be diagenetically altered (based on cathodoluminescence, elemental, and stable isotopic data). However, the Sr isotopic composition in diagenetically altered micritic matrix adjacent to the shell is more radiogenic. The Sr isotopic composition in the unaltered portions of calcitic megafossils has potential as a stratigraphic tool. (author)

  19. Strontium (Sr) separation from seawater using titanate adsorbents: Effects of seawater matrix ions on Sr sorption behavior

    Science.gov (United States)

    Ryu, Jungho; Hong, Hye-jin; Ryu, Taegong; Park, In-Su

    2017-04-01

    Strontium (Sr) which has many industrial applications such as ferrite magnet, ceramic, and fire works exists in seawater with the concentration of approximately 7 mg/L. In previous report estimating economic potential on recovery of various elements from seawater in terms of their commercial values and concentrations in seawater, Sr locates upper than approximate break-even line, which implies Sr recovery from seawater can be potentially profitable. Recently, Sr separation from seawater has received great attention in the environmental aspect after Fukushima Nuclear Power Plant (NPP) accident which released much amount of radioactive Sr and Cs. Accordingly, the efficient separation of radioactive elements released to seawater has become critical as an important technological need as well as their removal from radioactive wastes. So far, it has been introduced to separate Sr from aqueous media by various methods including solvent extraction, adsorption by solid materials, and ion exchange. Among them, the adsorption technique using solid adsorbents is of great interest for selectively separating Sr from seawater with respect to low concentration level of Sr. In this study, we synthesized titanate nanotube (TiNT) by simple hydrothermal reaction, characterized its physicochemical properties, and systematically evaluated Sr sorption behavior under various reaction conditions corresponding to seawater environment. The synthesized TiNT exhibited the fibril-type nanotube structure with high specific surface area of 260 m2/g. The adsorption of Sr on TiNT rapidly occurred following pseudo-second-order kinetic model, and was in good agreement with Langmuir isotherm model, indicating maximum adsorption capacity of 97 mg/g. Based on Sr uptake and Na release with stoichiometric balance, sorption mechanism of Sr on TiNT was found to be ion-exchange between Na in TiNT lattice and Sr in solution phase, which was also confirmed by XRD and Raman analysis. Among competitive ions, Ca

  20. Regional and interspecific variation in Sr, Ca, and Sr/Ca ratios in avian eggshells from the USA.

    Science.gov (United States)

    Mora, Miguel A; Brattin, Bryan; Baxter, Catherine; Rivers, James W

    2011-08-01

    To examine regional variation in strontium (Sr), which at high concentrations may reduce eggshell quality, increase egg breakage and reproductive failure, we analyzed Sr, and calcium (Ca) concentrations and Sr/Ca ratios in eggshells from 20 avian species from California, Texas, Idaho, Kansas, and Michigan. In addition, we included data previously reported from Arizona to expand the regional comparisons and to better establish patterns of Sr, and Sr/Ca ratios in bird species across the United States. We found Sr concentrations varied significantly among regions, among species, and among foraging guilds; this variability is strongly influenced by the Sr/Ca ratios in surface water from locations close to the region where the eggshells were collected. Sr concentrations and Sr/Ca ratios were significantly higher in bird eggshells from the Volta wildlife region in the San Joaquin Valley, California and in various locales from Arizona. Sr concentrations and Sr/Ca ratios in bird eggshells from other locations in the USA were lower than those detected in these two regions. Among foraging guilds, invertivores had the highest Sr concentrations and Sr/Ca ratios and carnivores had the lowest. In general, the Sr/Ca ratio increased strongly with increasing Sr concentrations (R(2) = 0.99, P eggshells suggesting that these values could be determined from Sr/Ca ratios in water. Eggshell thickness was poorly correlated with Sr (R(2) = 0.03) but had a significant and positive correlation with Ca and was more properly correlated by a quadratic equation (R(2) = 0.50, Thickness = 2.13 - 0.02Ca - 3.07 * 10(-5)Ca(2)). Our study provides further evidence that Sr accumulates significantly in the avian eggshell, in some regions at concentrations which could be of concern for potential negative effects on reproduction. We suggest that when assessing the effects of metals on avian reproduction in regions with high Sr deposits in rock and soil, Sr concentrations in the eggshell also should be

  1. μSR data analysis with XYfit

    International Nuclear Information System (INIS)

    Tucakov, Ivan; Brewer, Jess H.; Froese, Aaron; Lau, Angus

    2006-01-01

    The CERN MINUIT library has recently been ported to C++, facilitating the incorporation of that familiar package into a general purpose fitting application called XYfit with a graphical user interface built with Qt3. Custom theory functions can easily be added as 'plugins' to XYfit, which reads in DataTables in XML format generated by the μView spreadsheet utility (which see), thus allowing more flexible fitting of μSR spectra

  2. The μSR facilities at PSI

    International Nuclear Information System (INIS)

    Abela, R.; Baines, C.; Donath, X.; Herlach, D.; Maden, D.; Reid, I.D.; Renker, D.; Solt, G.; Zimmermann, U.

    1994-01-01

    The μSR Facility Instruments presently available at PSI and the envisaged medium- and long-term developments are presented. The plans focus on further upgrades of the existing instruments and the development of new techniques using the very high fluxes becoming available at PSI, in particular the setup of a beamline with a fast kicker for 'muons on request' (MORE) and the development of very low energy muon beams. (orig.)

  3. Implicazioni cliniche ed economiche di tramadolo SR

    Directory of Open Access Journals (Sweden)

    Lorenzo Pradelli

    2004-12-01

    Full Text Available Tramadol is one of the preferred weak opioid agonists in the management of chronic pain, due to a good efficacy and safety profile, to a particularly low interference with cardiovascular and respiratory functions and a low dependence and abuse potential. The successful use of tramadol, nevertheless, is often limited by low patient compliance, a consequence of gastrointestinal side effects (mainly nausea and vomiting and frequent dosing regimens, among other reasons. In this paper, clinical studies conducted on slow-release formulations of tramadol and other strategies for compliance improvement in various pain conditions are reviewed. From the examined literature, it appears that the strategy with the best compliance is the use of slow release (SR formulations, which simplify dosing regimens and tend to have a somewhat better tolerability, and a slow dose escalation, which improves tolerability. The advantages of SR formulations have to be weighed against the superior acquisition cost and the slower onset of analgesia. A frame for the evaluation of the clinical and economical advantages and disadvantages of SR versus immediate release formulations of tramadol is also proposed.

  4. A study of CR-39 plastic charged-particle detector replacement by consumer imaging sensors

    Energy Technology Data Exchange (ETDEWEB)

    Plaud-Ramos, K. O.; Freeman, M. S.; Wei, W.; Guardincerri, E.; Bacon, J. D.; Cowan, J.; Durham, J. M.; Huang, D.; Gao, J.; Hoffbauer, M. A.; Morley, D. J.; Morris, C. L.; Poulson, D. C.; Wang, Zhehui, E-mail: zwang@lanl.gov [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States)

    2016-11-15

    Consumer imaging sensors (CIS) are examined for real-time charged-particle detection and CR-39 plastic detector replacement. Removing cover glass from CIS is hard if not impossible, in particular for the latest inexpensive webcam models. We show that $10-class CIS are sensitive to MeV and higher energy protons and α-particles by using a {sup 90}Sr β-source with its cover glass in place. Indirect, real-time, high-resolution detection is also feasible when combining CIS with a ZnS:Ag phosphor screen and optics. Noise reduction in CIS is nevertheless important for the indirect approach.

  5. Australia's replacement research reactor project

    International Nuclear Information System (INIS)

    Harris, K.J.

    1999-01-01

    HIFAR, a 10 MW tank type DIDO Class reactor has operated at the Lucas Heights Science and Technology Centre for 43 years. HIFAR and the 10 kW Argonaut reactor 'Moata' which is in the Care and Maintenance phase of decommissioning are Australia's only nuclear reactors. The initial purpose for HIFAR was for materials testing to support a nuclear power program. Changing community attitude through the 1970's and a Government decision not to proceed with a planned nuclear power reactor resulted in a reduction of materials testing activities and a greater emphasis being placed on neutron beam research and the production of radioisotopes, particularly for medical purposes. HIFAR is not fully capable of satisfying the expected increase in demand for medical radiopharmaceuticals beyond the next 5 years and the radial configuration of the beam tubes severely restricts the scope and efficiency of neutron beam research. In 1997 the Australian Government decided that a replacement research reactor should be built by the Australian Nuclear Science and Technology Organisation at Lucas Heights subject to favourable results of an Environmental Impact Study. The Ei identified no reasons on the grounds of safety, health, hazard or risk to prevent construction on the preferred site and it was decided in May 1999 that there were no environmental reasons why construction of the facility should not proceed. In recent years ANSTO has been reviewing the operation of HIFAR and observing international developments in reactor technology. Limitations in the flexibility and efficiency achievable in operation of a tank type reactor and the higher intrinsic safety sought in fundamental design resulted in an early decision that the replacement reactor must be a pool type having cleaner and higher intensity tangential neutron beams of wider energy range than those available from HIFAR. ANSTO has chosen to use it's own resources supported by specialised external knowledge and experience to identify

  6. Preparation of Sr adsorptive fiber by impregnating with crown ether derivative for 90Sr measurement

    International Nuclear Information System (INIS)

    Horita, Takuma; Asai, Shiho; Hanzawa, Yukiko; Kitatsuji, Yoshihiro; Konda, Miki; Saito, Kyoichi; Fujiwara, Kunio; Sugo, Takanobu

    2017-01-01

    A Sr adsorption fiber was prepared for rapid analysis of 90 Sr content in the fiber using radiation-induced emulsion graft polymerization and subsequent chemical modification. A polyethylene fiber with a diameter of 13 μm was first immersed in a methanol solution of an epoxy-group-containing vinyl monomer, glycidyl methacrylate (GMA), and polyoxyethylene sorbitol ester (Tween20) as a surfactant for the graft-polymerization of GMA. Octadecylamine was then bound to a polymer chain extending from the fiber surface, providing hydrophobicity to the polymer chain. Dicyclohexano-18-crown-6 (DCH18C6) was finally impregnated onto the polymer chain via a hydrophobic interaction between the octadecyl moiety of the polymer chain and the cyclohexyl moiety of DCH18C6. The fiber surface structure, characterized by DCH18C6 molecules loosely entangled with polymer chains, allowed for the rapid adsorption of Sr ions at an adsorption rate of approximately 100-times higher than that of a commercially available Sr-selective resin (Sr Resin ® ). (author)

  7. Input of 87Sr/86Sr ratios and Sr geochemical signatures to update knowledge on thermal and mineral waters flow paths in fractured rocks (N-Portugal)

    International Nuclear Information System (INIS)

    Marques, J.M.; Carreira, P.M.; Goff, F.; Eggenkamp, H.G.M.; Antunes da Silva, M.

    2012-01-01

    Strontium isotopes and other geochemical signatures are used to determine the relationships between CO 2 -rich thermal (Chaves: 76 °C) and mineral (Vilarelho da Raia, Vidago and Pedras Salgadas: 17 °C) waters discharging along one of the major NNE–SSW trending faults in the northern part of mainland Portugal. The regional geology consists of Hercynian granites (syn-tectonic-310 Ma and post-tectonic-290 Ma) intruding Silurian metasediments (quartzites, phyllites and carbonaceous slates). Thermal and mineral waters have 87 Sr/ 86 Sr isotopic ratios between 0.716713 and 0.728035. 87 Sr/ 86 Sr vs. 1/Sr define three end-members (Vilarelho da Raia/Chaves, Vidago and Pedras Salgadas thermal and mineral waters) trending from rainfall composition towards that of the CO 2 -rich thermal and mineral waters, indicating different underground flow paths. Local granitic rocks have 87 Sr/ 86 Sr ratios of 0.735697–0.789683. There is no indication that equilibrium was reached between the CO 2 -rich thermal and mineral waters and the granitic rocks. The mean 87 Sr/ 86 Sr ratio of the thermal and mineral waters (0.722419) is similar to the Sr isotopic ratios of the plagioclases of the granitic rocks (0.71261–0.72087). The spatial distribution of Sr isotope and geochemical signatures of waters and the host rocks suggests that the thermal and mineral waters circulate in similar but not the same hydrogeological system. Results from this study could be used to evaluate the applicability of this isotope approach in other hydrogeologic investigations.

  8. Visual Image Sensor Organ Replacement

    Science.gov (United States)

    Maluf, David A.

    2014-01-01

    This innovation is a system that augments human vision through a technique called "Sensing Super-position" using a Visual Instrument Sensory Organ Replacement (VISOR) device. The VISOR device translates visual and other sensors (i.e., thermal) into sounds to enable very difficult sensing tasks. Three-dimensional spatial brightness and multi-spectral maps of a sensed image are processed using real-time image processing techniques (e.g. histogram normalization) and transformed into a two-dimensional map of an audio signal as a function of frequency and time. Because the human hearing system is capable of learning to process and interpret extremely complicated and rapidly changing auditory patterns, the translation of images into sounds reduces the risk of accidentally filtering out important clues. The VISOR device was developed to augment the current state-of-the-art head-mounted (helmet) display systems. It provides the ability to sense beyond the human visible light range, to increase human sensing resolution, to use wider angle visual perception, and to improve the ability to sense distances. It also allows compensation for movement by the human or changes in the scene being viewed.

  9. Gene replacement in Penicillium roqueforti.

    Science.gov (United States)

    Goarin, Anne; Silar, Philippe; Malagnac, Fabienne

    2015-05-01

    Most cheese-making filamentous fungi lack suitable molecular tools to improve their biotechnology potential. Penicillium roqueforti, a species of high industrial importance, would benefit from functional data yielded by molecular genetic approaches. This work provides the first example of gene replacement by homologous recombination in P. roqueforti, demonstrating that knockout experiments can be performed in this fungus. To do so, we improved the existing transformation method to integrate transgenes into P. roqueforti genome. In the meantime, we cloned the PrNiaD gene, which encodes a NADPH-dependent nitrate reductase that reduces nitrate to nitrite. Then, we performed a deletion of the PrNiaD gene from P. roqueforti strain AGO. The ΔPrNiaD mutant strain is more resistant to chlorate-containing medium than the wild-type strain, but did not grow on nitrate-containing medium. Because genomic data are now available, we believe that generating selective deletions of candidate genes will be a key step to open the way for a comprehensive exploration of gene function in P. roqueforti.

  10. Serum Creatinine: Not So Simple!

    Science.gov (United States)

    Delanaye, Pierre; Cavalier, Etienne; Pottel, Hans

    2017-01-01

    Measuring serum creatinine is cheap and commonly done in daily practice. However, interpretation of serum creatinine results is not always easy. In this review, we will briefly remind the physiological limitations of serum creatinine due notably to its tubular secretion and the influence of muscular mass or protein intake on its concentration. We mainly focus on the analytical limitations of serum creatinine, insisting on important concept such as reference intervals, standardization (and IDMS traceability), analytical interferences, analytical coefficient of variation (CV), biological CV and critical difference. Because the relationship between serum creatinine and glomerular filtration rate is hyperbolic, all these CVs will impact not only the precision of serum creatinine but still more the precision of different creatinine-based equations, especially in low or normal-low creatinine levels (or high or normal-high glomerular filtration rate range). © 2017 S. Karger AG, Basel.

  11. Serum-free Erythroid Differentiation for Efficient Genetic Modification and High-Level Adult Hemoglobin Production.

    Science.gov (United States)

    Uchida, Naoya; Demirci, Selami; Haro-Mora, Juan J; Fujita, Atsushi; Raines, Lydia N; Hsieh, Matthew M; Tisdale, John F

    2018-06-15

    In vitro erythroid differentiation from primary human cells is valuable to develop genetic strategies for hemoglobin disorders. However, current erythroid differentiation methods are encumbered by modest transduction rates and high baseline fetal hemoglobin production. In this study, we sought to improve both genetic modification and hemoglobin production among human erythroid cells in vitro . To model therapeutic strategies, we transduced human CD34 + cells and peripheral blood mononuclear cells (PBMCs) with lentiviral vectors and compared erythropoietin-based erythroid differentiation using fetal-bovine-serum-containing media and serum-free media. We observed more efficient transduction (85%-93%) in serum-free media than serum-containing media (20%-69%), whereas the addition of knockout serum replacement (KSR) was required for serum-free media to promote efficient erythroid differentiation (96%). High-level adult hemoglobin production detectable by electrophoresis was achieved using serum-free media similar to serum-containing media. Importantly, low fetal hemoglobin production was observed in the optimized serum-free media. Using KSR-containing, serum-free erythroid differentiation media, therapeutic adult hemoglobin production was detected at protein levels with β-globin lentiviral transduction in both CD34 + cells and PBMCs from sickle cell disease subjects. Our in vitro erythroid differentiation system provides a practical evaluation platform for adult hemoglobin production among human erythroid cells following genetic manipulation.

  12. Thermodynamic assessment of the Pb-Sr system

    Directory of Open Access Journals (Sweden)

    Zhang H.

    2017-01-01

    Full Text Available The Pb-Sr system has been critically reviewed and modeled by means of the CALPHAD (CALculation of PHAse Diagrams approach. It contains seven stoichiometric compounds, i.e. SrPb3, Sr3Pb5, Sr2Pb3, SrPb, Sr5Pb4, Sr5Pb3 and Sr2Pb, in which the SrPb3 and Sr2Pb phases melt congruently, and the other five phases form via peritectic reactions. The enthalpies of formation for the intermetallic compounds at 0 K are provided by first-principles calculations. The liquid, fcc and bcc phases are modeled as substitutional solution phases. Both Redlich-Kister and exponential polynomials are used to describe the excess Gibbs energy of the liquid. Two sets of self-consistent thermodynamic parameters are obtained by considering reliable experimental data and the computed enthalpies of formation. Comprehensive comparisons between the calculated and measured phase diagram and thermodynamic data show that the experimental information is satisfactorily accounted for by the present thermodynamic description.

  13. Rb-Sr and Nd-Sr isotope geochemistry and petrogenesis of the Misho Mountains mafic dikes (NW Iran

    Directory of Open Access Journals (Sweden)

    Maryam Ahankoub

    2017-02-01

    Full Text Available Introduction There are some theories about the Paleotethys event during the Paleozoic that have been proposed by geologists (Metcalfe, 2006. Some scientist offered some pieces of evidence about the northern margin of Gondwana (Zhu et al., 2010. The Paleotethys Ocean and Hercynian orogenic report first in Iran, have been Offered from the Morrow and Misho Mountain (Eftekharnejad, 1981. Misho Mountains is located between the north and south Misho faults and cause the formation of a positive flower structure (Moayyed and Hossainzade, 2011. There is theory about Misho southern fault as the best candidate of the Paleotethys suture zone (Moayyed and Hossainzade, 2011. Geochemistry and Sr –Nd isotopic data of the A2 granitic and Synite rocks of the East Misho, indicate that the magmatism post collision has occurred in the active continental margin by extensional zones of the following the closure of the Paleotethys (Ahankoub, 2012. Granite and syenite rocks have been cut by mafic dikes. Mafic dikes are often formed in extensional tectonic settings related to mantle plume or continental break –up (Zhu et al., 2009. In this paper, we use the geochemistry and Nd-Sr isotope data to determined petrogenesis, tectono-magmatic setting and age of Misho mafic dikes. Materials and methods After petrography study of 30 thin sections of mafic dike rocks, 8 samples were selected for whole-rock chemical analyses using ICP-MS and ICP-AES instruments by ACME Company in Vancouver, Canada. We prepared 6 sample For Sm-Nd and Rb-Sr analysis. Sr and Nd isotope ratios were measured with a thermal ionization mass spectrometer, VG Sector 54–30 at the Nagoya University. The isotope abundances of Rb, Sr, Nd, and Sm were measured by the ID method with a Finnigan MAT Thermoquad THQ thermal ionization quadrupole mass spectrometer at the Nagoya University. NBS987 and JNdi-1 were measured as natural Sr and Nd isotope ratio standards (Tanaka et al., 2000. Averages and 2σ errors

  14. Radioimmunoassay of cholylglycine in serum

    International Nuclear Information System (INIS)

    Wakushima, Tadashi; Yamanishi, Yasuhito; Hirayama, Chisato

    1979-01-01

    Serum levels of cholylglycines (CG) were determined by radioimmunoassay and that of total bile acids (TBA) by enzymatic method. In normal subjects, serum levels of CG, TBA and CG/TBA ratio were 0.6 +- 0.4 μM, 7 +- 2 μM, and 0.08 +- 0.06, respectively. They were increased markedly in acute hepatitis and moderately in chronic hepatitis and cirrhosis. Thus, measurement of serum CG as compared with serum TBA appears to be a sensitive liver test. (author)

  15. Opportunistic replacement of fusion power system parts

    International Nuclear Information System (INIS)

    Day, J.A.; George, L.L.

    1981-01-01

    This paper describes a maintenance problem in a fusion power plant. The problem is to specify which life limited parts should be replaced when there is an opportunity. The objective is to minimize the cost rate of replacement parts and of maintenance actions while satisfying a power plant availability constraint. The maintenance policy is to look ahead and replace all parts that will reach their life limits within a time called a screen. Longer screens yield greater system availabilities because more parts are replaced prior to their life limits

  16. Rapid determination of {sup 90}Sr in urine samples using AnaLig Sr-01

    Energy Technology Data Exchange (ETDEWEB)

    Bilohuscin, J.; Dulanska, S.; Gardonova, V. [Univerzita Komenskeho, Prirodovedecka fakulta, Katedra jadrovej chemie, 84215 Bratislava (Slovakia)

    2013-04-16

    This work describes the use of IBC's AnaLig Sr-01 molecular recognition technology product to effectively and selectively pre-concentrate, separate and recover strontium from urine samples. This method uses two-stage columns separation consisting of two different commercial products Eichrom's Pre-filter Material and AnaLig Sr-01 column from IBC Advanced Technologies. This method does not involve co-precipitation of strontium as phosphates and oxalates from urine samples. The new rapid method separates strontium-90 with high chemical recovery (authors)

  17. Some analytical aspects about determination of Sr89 and Sr90 in environmental samples

    International Nuclear Information System (INIS)

    Gasco, C.; Alvarez Garcia, A.

    1988-01-01

    Some problems about determination of Sr 89 and Sr 90 in environmental samples have been studied. The main difficulties are due to the wide range in the concentration of their components and the contents of chemical and radiochemical interferent elements. The behaviour of strontium on ion exchange resin has been described by some experiments in various media: aqueous media, calcium concentration and matrix variable. The differences of alkaline-earth nitrate and carbonate solubilities have been analyzed in nitric acid. The chemical recovery in environmental samples has been determined. (Author)

  18. Aortic valve replacement in octogenarians

    Directory of Open Access Journals (Sweden)

    Dark John H

    2007-07-01

    Full Text Available Abstract Background and Aims As our population ages and life expectancy increases the number of people aged over 80 and more referred for cardiac surgery is growing. This study sought to identify the outcome of aortic valve replacement (AVR in octogenarians. Methods 68 patients aged 80 years or more underwent AVR at the Freeman Hospital, between April 2001 and April 2004. A retrospective review of the notes and outcomes from the patients' GP and the NHS strategic tracking service was performed. 54% (37 underwent isolated AVR whilst 46% (31 underwent combined AVR and CABG. Results Follow up was 100% complete. The mean age was 83.1 ± s.d. 2.9 years, a mean gradient of 83 ± s.d. 31 mmHg and mean AVA of 0.56 cm2. The mean additive EuroSCORE was 8.6 ± s.d. 1.2, the logistic EuroSCORE mean 12.0 ± s.d. 5.9. In hospital 30 day mortality was 13 %. Survival was 80% at 1 year and 78% at 2 years. Median follow up was for 712 days. Stepwise logistic regression identified chronic obstructive airways disease as an independent predictor of mortality (p Conclusion Our study demonstrates that the operative mortality for AVR in the over eighties is good, whilst the mid to long term outcome is excellent There is a very low attrition rate with those undergoing the procedure living as long than their age matched population. This study confirms AVR is a safe, acceptable treatment for octogenarians with excellent mid term outcomes.

  19. Menopause and hormone replacement therapy

    Directory of Open Access Journals (Sweden)

    Ali Baziad

    2001-12-01

    Full Text Available The global population in the 21st century has reached 6.2 billion people, by the year 2025 it is to be around 8.3-8.5 billion, and will increase further. Elderly people are expected to grow rapidly than other groups. The fastest increase in the elderly population will take place in Asia. Life expectancy is increasing steadily throughout developed and developing countries. For many  menopausal women, increased life expectancy will accompanied by many health problems. The consequences of estrogen deficiency are the menopausal symptoms. The treatment of menopause related complaints and diseases became an  important socioeconomic and medical issue. Long term symptoms, such as the increase in osteoporosis fractures, cardio and cerebrovascular disesses and dementia, created a large financial burden on individuals and society. All these health problems can be lreated or prevented by hormone replacement therapy (HRT. Natural HRT is usually prefened. Synthetic  estrogen in oral contraceptives (oc are not recommended for HRT. Many contra-indications for oc, but now it is widely usedfor HRT. The main reasons for discontinuing HRT are unwanted bleeding, fear of cancer, and negative side effects. Until now there are sill debates about the rebrtonship between HRT and the incidence of breast cancer. Many data showed that there were no clear relationship between the use of HRT and breast cancer. ThereÎore, nwny experts advocate the use of HRTfrom the first sign of climacteric complaints until death. (Med J Indones 2001;10: 242-51Keywords: estrogen deficiency, climacteric phases, tibolone.

  20. Replacing Fortran Namelists with JSON

    Science.gov (United States)

    Robinson, T. E., Jr.

    2017-12-01

    Maintaining a log of input parameters for a climate model is very important to understanding potential causes for answer changes during the development stages. Additionally, since modern Fortran is now interoperable with C, a more modern approach to software infrastructure to include code written in C is necessary. Merging these two separate facets of climate modeling requires a quality control for monitoring changes to input parameters and model defaults that can work with both Fortran and C. JSON will soon replace namelists as the preferred key/value pair input in the GFDL model. By adding a JSON parser written in C into the model, the input can be used by all functions and subroutines in the model, errors can be handled by the model instead of by the internal namelist parser, and the values can be output into a single file that is easily parsable by readily available tools. Input JSON files can handle all of the functionality of a namelist while being portable between C and Fortran. Fortran wrappers using unlimited polymorphism are crucial to allow for simple and compact code which avoids the need for many subroutines contained in an interface. Errors can be handled with more detail by providing information about location of syntax errors or typos. The output JSON provides a ground truth for values that the model actually uses by providing not only the values loaded through the input JSON, but also any default values that were not included. This kind of quality control on model input is crucial for maintaining reproducibility and understanding any answer changes resulting from changes in the input.

  1. Relationship between serum total magnesium and serum potassium ...

    African Journals Online (AJOL)

    Relationship between serum total magnesium and serum potassium in emergency surgical patients in a tertiary hospital in Ghana. Robert Djagbletey, Brenda Phillips, Frank Boni, Christian Owoo, Ebenezer Owusu-Darkwa, Papa Kobina Gyakye deGraft-Johnson, Alfred E. Yawson ...

  2. Development of humanized culture medium with plant-derived serum replacement for human pluripotent stem cells

    Czech Academy of Sciences Publication Activity Database

    Kunová, M.; Matulka, K.; Eiselleová, L.; Trčková, P.; Hampl, Aleš; Dvořák, Petr

    2010-01-01

    Roč. 21, - (2010), s. 676-686 ISSN 1472-6483 Grant - others:GA MŠk(CZ) LC06077; EC FP6(XE) LSHG-CT-2006-018739 Program:LC Institutional research plan: CEZ:AV0Z50390512; CEZ:AV0Z50390703 Keywords : animal protein-free culture * high-density culture * human embryonic stem cells Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.285, year: 2010

  3. Neurotensin type 1 receptor-mediated activation of krox24, c-fos and Elk-1: preventing effect of the neurotensin antagonists SR 48692 and SR 142948.

    Science.gov (United States)

    Portier, M; Combes, T; Gully, D; Maffrand, J P; Casellas, P

    1998-07-31

    Stimulation of neurotensin (NT) type 1 receptors (NT1-R) in transfected CHO cells is followed by the activation of mitogen-activated protein kinases and the expression of the early response gene krox24. By making point mutations and internal deletions in the krox24 promoter, we show that proximal serum responsive elements (SRE) are involved in transcriptional activation by NT. In addition, we show that the related early response gene c-fos and the Ets protein Elk-1 are also induced by NT. The involvement of NT1-R in NT-mediated activation of krox24, c-fos and Elk-1 was demonstrated by the preventing effect of the specific antagonists SR 48692 and SR 142948. Finally, we show that the activation of krox24 and Elk-1 on the one hand, and that of c-fos on the other hand, result from independent transduction pathways since the former are pertussis toxin-sensitive whereas the latter is insensitive to pertussis toxin.

  4. Serum prolidase activity and oxidative status in Helicobacter pylori infection.

    Science.gov (United States)

    Aslan, Mehmet; Nazligul, Yasar; Horoz, Mehmet; Bolukbas, Cengiz; Bolukbas, Fusun F; Aksoy, Nurten; Celik, Hakim; Erel, Ozcan

    2007-01-01

    During the course of Helicobacter pylori infection, increased oxidative stress plays an important role in the pathogenesis of gastroduodenal mucosal inflammation, which can cause gastric mucosal atrophy that characterized by the replacement of the gastric mucosal glands by collagen fibers. In the present study, we aimed to determine serum prolidase activity and oxidative status, and to find out if there is any association between serum prolidase activity and oxidative status in H. pylori infection. Forty H. pylori-positive and 32 H. pylori-negative subjects were enrolled. Serum prolidase activity was measured spectrophotometrically. Oxidative status was determined using total antioxidant capacity and total oxidant status measurement and calculation of oxidative stress index. Total antioxidant capacity level was lower in H. pylori-positive group than H. pylori-negative group (ptotal oxidant status, oxidative stress index and prolidase activity were higher (all ptotal antioxidant capacity, total oxidant status and oxidative stress index (p<0.01, r=-0.367; p<0.05, r=0.283; p<0.01, r=0.379; respectively) in H. pylori-positive subjects. H. pylori infection may be associated with increased oxidative stress and increased serum prolidase activity. Increased oxidative stress seems to be associated with increased serum prolidase activity and this association may help to provide a better understanding about the pathogenesis of H. pylori infection.

  5. Thermodynamic modeling of the Sr-Co-Fe-O system

    DEFF Research Database (Denmark)

    Zhang, Wei Wei; Povoden-Karadeniz, Erwin; Chen, Ming

    2016-01-01

    This paper reviews and assesses phase equilibria and thermodynamic properties of phases in the Sr-Co-Fe-O system, with a focus on oxides, especially the SrCo1 - xFexO3 - δ perovskite. In our work, the SrCo1 - xFexO3 - δ perovskite was modeled with a three-sublattice model, where the three...... sublattices correspond to the A, B and oxygen sites in an ABO3 perovskite, respectively. A number of other important ternary oxide phases in Sr-Co-O and Sr-Co-Fe-O were also considered. Available thermodynamic and phase diagram data were carefully assessed. A thermodynamic description of Sr-Co-O was derived...

  6. Steroid replacement in primary adrenal failure does not appear to affect circulating adipokines

    OpenAIRE

    Fichna, Marta; Fichna, Piotr; Gryczy?ska, Maria; Czarnywojtek, Agata; ?urawek, Magdalena; Rucha?a, Marek

    2014-01-01

    Despite continuous efforts for an optimal steroid replacement, recent observations suggest increased cardiometabolic risk and related mortality in primary adrenal insufficiency (PAI). Adipokines are peptides from the adipose tissue, markers of cardiometabolic dysfunction. This study was aimed to evaluate serum levels of adipokines: leptin, adiponectin, and resistin in PAI during conventional steroid substitution. The analysis comprised 63 patients (mean age 42.7???14.1?years) and 63 healthy c...

  7. Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene.

    Science.gov (United States)

    Bass, Jonathan Y; Caravella, Justin A; Chen, Lihong; Creech, Katrina L; Deaton, David N; Madauss, Kevin P; Marr, Harry B; McFadyen, Robert B; Miller, Aaron B; Mills, Wendy Y; Navas, Frank; Parks, Derek J; Smalley, Terrence L; Spearing, Paul K; Todd, Dan; Williams, Shawn P; Wisely, G Bruce

    2011-02-15

    To improve on the drug properties of GSK8062 1b, a series of heteroaryl bicyclic naphthalene replacements were prepared. The quinoline 1c was an equipotent FXR agonist with improved drug developability parameters relative to 1b. In addition, analog 1c lowered body weight gain and serum glucose in a DIO mouse model of diabetes. Copyright © 2010 Elsevier Ltd. All rights reserved.

  8. Colour relations for Mira and Semiregular (SR) type stars

    International Nuclear Information System (INIS)

    Guney, Yavuz; Yesilyaprak, Cahit

    2016-01-01

    In this study, the period-colour relations, the colour-colour relations and the effective temperature were examined for Semiregular (SR) and Mira type variable stars. SR variables show an obvious period-colour relations, especially in infrared (IR). There are differences between SR and Mira type variable stars with respect to their colour relations. It has been thought that these differencies are caused by their mass loss rates and their effective temperatures. (paper)

  9. Changes of Serum Total and Free Testosterone Concentrations in Male Chronic Hemodialysis Patients with Secondary Hyperparathyroidism in Response to Cinacalcet Treatment

    Directory of Open Access Journals (Sweden)

    Piotr Kuczera

    2016-01-01

    Full Text Available Background/Aims: Calcium sensing receptor (CaSR is expressed, among others also in testis. Cinacalcet binds to the CaSR, increases sensitivity of CaSR to serum calcium and is used in the treatment of secondary hyperparathyroidism (sHPT in chronic hemodialysis patients (HDP. In most of male HDP, serum testosterone concentration is lower than in healthy males. The aim of this study was to assess the influence of six-month treatment with cinacalcet on the serum total and free testosterone concentration in male HDP with sHPT. Methods: 38 male, hemodialysed CKD patients with sHPT (PTH>300 pg/ml were enrolled into the study. In each patient serum PTH, total testosterone (TT and free testosterone (FT concentrations were assessed before the first dose of cinacalcet and then after 3 and 6 months of treatment. The results are presented as means with 95% confidence interval. Results: In 33 patients who completed the study cinacalcet treatment caused significant decrease of serum PTH from 1143 pg/ml (828 - 1458 pg/ml at the baseline, to 809 pg/ml (487 - 1132pg/ml after 3 month of treatment (p = 0.002, and to 607 pg/ml (281 - 934pg/ml; p Conclusion: Treatment with cinacalcet decreases serum total and free testosterone concentration in male hemodialysed patients with chronic kidney disease and secondary hyperparathyroidism.

  10. Are brown trout replacing or displacing bull trout populations in a changing climate?

    Science.gov (United States)

    Al-Chokhachy, Robert K.; Schmetterling, David A.; Clancy, Chris; Saffel, Pat; Kovach, Ryan; Nyce, Leslie; Liermann, Brad; Fredenberg, Wade A.; Pierce, Ron

    2016-01-01

    Understanding how climate change may facilitate species turnover is an important step in identifying potential conservation strategies. We used data from 33 sites in western Montana to quantify climate associations with native bull trout (Salvelinus confluentus) and non-native brown trout (Salmo trutta) abundance and population growth rates (λ). We estimated λ using exponential growth state space models and delineated study sites based on bull trout use for either Spawning and Rearing (SR) or Foraging, Migrating, and Overwintering (FMO) habitat. Bull trout abundance was negatively associated with mean August stream temperatures within SR habitat (r = -0.75). Brown trout abundance was generally highest at temperatures between 12 and 14°C. We found bull trout λ were generally stable at sites with mean August temperature below 10°C but significantly decreasing, rare, or extirpated at 58% of the sites with temperatures exceeding 10°C. Brown trout λ were highest in SR and sites with temperatures exceeding 12°C. Declining bull trout λs at sites where brown trout were absent suggests brown trout are likely replacing bull trout in a warming climate.

  11. Effect of steroid replacement on thyroid function and thyroid autoimmunity in Addison's disease with primary hypothyroidism.

    Science.gov (United States)

    Sahoo, Jaya Prakash; Selviambigapathy, Jayakumar; Kamalanathan, Sadishkumar; Nagarajan, K; Vivekanandan, Muthupillai

    2016-01-01

    Steroid replacement without thyroxine supplementation normalizes thyroid function test (TFT) in some but not all Addison's disease patients with primary hypothyroidism. Both autoimmune and nonautoimmune mechanisms contribute to this improvement in TFT. However, the documentation of the change in thyroid autoimmunity after cortisol replacement is very limited in the literature. The aim of this study was to determine the effect of steroid replacement on TFT and anti-thyroid peroxidase antibody (anti-TPO-Ab) titer in Addison's disease with primary hypothyroidism. This observational study was conducted in a tertiary care center in South India. Six Addison's disease patients with primary hypothyroidism, who were only on steroid replacement, were included in the study. Low serum cortisol (22 pmol/L) and/or hyperpigmentation of skin/mucous membranes was considered as the diagnostic criteria for Addison's disease. Primary hypothyroidism (both overt and subclinical) was defined as high thyroid stimulating hormone (TSH) with/without low free thyroxine (fT4). TFT and anti-TPO-Ab were performed before and after steroid replacement in all of them. Poststeroid replacement, there was a normalization of TSH in all but one subjects. In overt hypothyroidism patients, fT4 also normalized. The improvement in TFT was not associated with decreasing titer of the anti-TPO-Ab in all six patients. However, there was a significant difference in TSH after steroid replacement compared to the baseline status. The concept of normalization of primary hypothyroidism with cortisol replacement in patients with Addison's disease should be recognized to avoid iatrogenic thyrotoxicosis caused by thyroxine replacement. Both autoimmune and nonautoimmune mechanisms contribute to these alterations.

  12. Effect of steroid replacement on thyroid function and thyroid autoimmunity in Addison's disease with primary hypothyroidism

    Science.gov (United States)

    Sahoo, Jaya Prakash; Selviambigapathy, Jayakumar; Kamalanathan, Sadishkumar; Nagarajan, K.; Vivekanandan, Muthupillai

    2016-01-01

    Background: Steroid replacement without thyroxine supplementation normalizes thyroid function test (TFT) in some but not all Addison's disease patients with primary hypothyroidism. Both autoimmune and nonautoimmune mechanisms contribute to this improvement in TFT. However, the documentation of the change in thyroid autoimmunity after cortisol replacement is very limited in the literature. The aim of this study was to determine the effect of steroid replacement on TFT and anti-thyroid peroxidase antibody (anti-TPO-Ab) titer in Addison's disease with primary hypothyroidism. Materials and Methods: This observational study was conducted in a tertiary care center in South India. Six Addison's disease patients with primary hypothyroidism, who were only on steroid replacement, were included in the study. Low serum cortisol (22 pmol/L) and/or hyperpigmentation of skin/mucous membranes was considered as the diagnostic criteria for Addison's disease. Primary hypothyroidism (both overt and subclinical) was defined as high thyroid stimulating hormone (TSH) with/without low free thyroxine (fT4). TFT and anti-TPO-Ab were performed before and after steroid replacement in all of them. Results: Poststeroid replacement, there was a normalization of TSH in all but one subjects. In overt hypothyroidism patients, fT4 also normalized. The improvement in TFT was not associated with decreasing titer of the anti-TPO-Ab in all six patients. However, there was a significant difference in TSH after steroid replacement compared to the baseline status. Conclusions: The concept of normalization of primary hypothyroidism with cortisol replacement in patients with Addison's disease should be recognized to avoid iatrogenic thyrotoxicosis caused by thyroxine replacement. Both autoimmune and nonautoimmune mechanisms contribute to these alterations. PMID:27042409

  13. DETERMINATION OF SERUM ALBUMIN WITH ...

    African Journals Online (AJOL)

    The reaction of tribromoarsenazo(TB-ASA) with serum albumin in the presence of emulgent OP was studied by spectrophotometry. In a Britton-Robinson buffer solution at pH 2.9, tribromoarsenazo and bovine serum albumin can immediately form a red compound in the presence of emulgent OP with a maximum absorption ...

  14. Aliens or the SR-71 Blackbird?

    Science.gov (United States)

    Ruiz, Michael J.

    2006-04-01

    Unidentified flying objects (UFOs) capture the interest of our students and the general public.1,2 Here is a UFO story I tell my students to illustrate the workings of science. Science, at its most fundamental level, is observation and an attempt to analyze what is observed. But what happens when an observation cannot be explained with the available knowledge at the time? What do we do? The UFO sighting of my story could not be explained until disclosure of a top-secret military aircraft, the SR-71, also known as the "Blackbird."

  15. Worldwide deposition of 90Sr through 1984

    International Nuclear Information System (INIS)

    Larsen, R.J.; Juzdan, Z.R.

    1986-10-01

    The deposition of 90 Sr in the Northern Hemisphere during 1984 was 0.3 PBq (0.008 MCi), while that of the Southern Hemisphere was 0.1 PBq (0.003 MCi). This resulted in a total deposition on the surface of the earth during 1984 of 0.4 PBq (0.011 MCi). This is the lowest total yearly deposit since the initiation of the Environmental Measurements Laboratory's global fallout program in the mid-1950's. The worldwide cumulative deposit decreased to 357 PBq (9.6 MCi)

  16. Comments on geochemical aspects of SR 97

    International Nuclear Information System (INIS)

    Arthur, R.C.; Wei Zhou

    2000-01-01

    The Swedish Government has asked SKB to carry out a safety assessment of the KBS-3 disposal concept for spent nuclear fuel 'to demonstrate that the KBS-3 method has good prospects of being able to meet the safety and radiation protection requirements which SKI and SSI have specified in recent years.' The results of that assessment, referred to as SR 97, have recently been published. The present report summarizes the results of a review of selected geochemical aspects of SR 97. These subjects include the hydrochemical evolution of a defective canister, thermodynamic data supporting estimates of radioelement solubilities, modeling of near-field chemistry and analyses of the effects of ice melting on propagation of an oxidizing front to repository depths. The primary focus of the review is on the canister-defect scenario, and, more specifically, on supporting analyses of the hydromechanical evolution of a defective canister. The results of these analyses figure prominently in the safety assessment because they suggest that even a defective canister will, in effect, remain dry for as long as 200,000 years. This is an important constraint because it is taken in SR 97 as the period of time required for a continuous water pathway to form in the near field. The transport of most radionuclides (i.e., those that do not exist as a gas) cannot occur until this pathway is formed. It is concluded that although SKBs hydromechanical models are sound, they may suffer from an over-simplification of the chemical processes involved. Analyses using the models do not acknowledge that the chemical system within the canister is open in all respects to the chemical system in the buffer. Instead, mass transfer across the defect at the canister-buffer interface is limited to liquid H 2 O and water vapor. Consideration of mass transfer of other gases [e.g., CO 2 and H 2 S] dissolved in buffer porewaters suggests that associated reactions involving the iron insert and inner surfaces of the

  17. μ+SR diffusion studies at LAMPF

    International Nuclear Information System (INIS)

    Heffner, R.H.; Parkin, D.M.; Huang, C.Y.; Hutson, R.L.; Leon, M.; Schillaci, M.E.; Simmons, M.L.; Gauster, W.B.; Triftshaeuser, W.

    1978-01-01

    μ + SR measurements are reported for Cu and Al over the temperature range from 19K to just below the melting points, together with measurements on V and Ta from 19K to 295K. Al had a much lower depolarisation rate than Cu suggesting that positive muons are not localised in Al at low temperature as in Cu. Depolarisation was absent in Al and Cu at high temperature. V shows a similar depolarisation magnitude as Cu, but with different temperature behaviour. Ta appears to behave like Al. (Auth.)

  18. 30 CFR 57.19122 - Replacement parts.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Replacement parts. 57.19122 Section 57.19122 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Inspection and Maintenance § 57.19122 Replacement parts. Parts used to repair hoists shall have properties...

  19. Transcatheter Aortic Valve Replacement in Europe

    DEFF Research Database (Denmark)

    Mylotte, Darren; Osnabrugge, Ruben L J; Windecker, Stephan

    2013-01-01

    The authors sought to examine the adoption of transcatheter aortic valve replacement (TAVR) in Western Europe and investigate factors that may influence the heterogeneous use of this therapy.......The authors sought to examine the adoption of transcatheter aortic valve replacement (TAVR) in Western Europe and investigate factors that may influence the heterogeneous use of this therapy....

  20. 30 CFR 56.19122 - Replacement parts.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Replacement parts. 56.19122 Section 56.19122 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Inspection and Maintenance § 56.19122 Replacement parts. Parts used to repair hoists shall have properties...

  1. An abstract machine for module replacement

    OpenAIRE

    Walton, Chris; Krl, Dilsun; Gilmore, Stephen

    1998-01-01

    In this paper we define an abstract machine model for the mλ typed intermediate language. This abstract machine is used to give a formal description of the operation of run-time module replacement from the programming language Dynamic ML. The essential technical device which we employ for module replacement is a modification of two-space copying garbage collection.

  2. Temelin NPP - IandC replacement

    International Nuclear Information System (INIS)

    Spalenka, I.

    1997-01-01

    The original instrumentation and control system of the Temelin nuclear power plant is being upgraded and replaced by a modern Westinghouse-supplied system which meets the requirements imposed on current nuclear power plant designs. The history and purpose of the IandC system replacement is given, and the design of the new system is described in some detail. (A.K.)

  3. Replacement Value of fermented millet ( Pennisetum americanum ...

    African Journals Online (AJOL)

    The replacement value of fermented millet for maize in the diets of Clarias gariepinus fingerlings reared in a recirculation system was determined. Five isonitrogenous diets were formulated to contain graded levels of fermented millet meal replacing 0, 20, 40, 60 and 80% of maize and fed to triplicate groups of fingerlings ...

  4. 30 CFR 823.14 - Soil replacement.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Soil replacement. 823.14 Section 823.14 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR PERMANENT PROGRAM PERFORMANCE STANDARDS SPECIAL PERMANENT PROGRAM PERFORMANCE STANDARDS-OPERATIONS ON PRIME FARMLAND § 823.14 Soil replacement. (a) Soil...

  5. A useful framework for optimal replacement models

    International Nuclear Information System (INIS)

    Aven, Terje; Dekker, Rommert

    1997-01-01

    In this note we present a general framework for optimization of replacement times. It covers a number of models, including various age and block replacement models, and allows a uniform analysis for all these models. A relation to the marginal cost concept is described

  6. 7 CFR 1944.659 - Replacement housing.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true Replacement housing. 1944.659 Section 1944.659 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS...) PROGRAM REGULATIONS (CONTINUED) HOUSING Housing Preservation Grants § 1944.659 Replacement housing...

  7. Peculiarities of Sr-90 migration in the environment

    International Nuclear Information System (INIS)

    Romanov, G.N.; Stukin, D.A.; Aleksakhin, R.M.

    1991-01-01

    The Eastern Urals radioactive track which formed as a result of the Kyshtym accident constituted a natural experimental base for studying the dynamics of Sr-90 behaviour and migration in the environment. Sr-90 behaviour in soil depends on the processes involved in its physical migration horizontally (water runoff, wind transport) and vertically (effective diffusion), on the intensity with which the physico-chemical forms of strontium change, and primarily on Sr-90 incorporation into the soil-absorptive complex. Over 30 years the effective diffusion processes led to downward displacement of Sr-90 in undisturbed soil to a depth of 30 to 50 cm. In 1988 84-94% of the Sr-90 was located in the 10 cm layer as against 90% in the 2 cm layer in the initial 1 or 2 years. The amount of Sr-90 in mobile forms in leached chernozem and grey forest soil hardly changed over time, amounting to between 76 and 90%. In the first 5-10 years Sr-90 surface water runoff was about 0.2% (and Sr-90 wind resuspension 0.1-1.0%) per year of the Sr-90 inventory per unit area. Due to Sr-90 loss from the top soil layer the water runoff and wind resuspension processes decreased exponentially, halving every 4 to 5 years. In most cases, Sr-90 transfer from soil to plants via the roots does not involve discrimination of Sr-90 with regard to calcium, and therefore the Sr-90 accumulation level in various species of natural and agricultural plants depends on their calcium requirements and the amount of exchangeable calcium in the soil. This made it possible to work out quantitative indices for forecasting Sr-90 accumulation in various species of plants for given types of soil. As Sr-90 moves through the trophic chains (including the agricultural one) we find - depending on whether two adjoining links discriminate against it or not as regards calcium - that some organisms reject it while others concentrate it. When restoring farming on the contaminated territory the fact that cattle discriminated against Sr

  8. [Exogenous Sr2+ sedimentation on otolith of chum salmon embryos].

    Science.gov (United States)

    Wang, Chen; Liu, Wei; Zhan, Pei-rong; Wang, Ji-long; Li, Pei-lun

    2015-10-01

    To explore the exogenous Sr2+ sedimentation on otolith of chum salmon embryos, chum salmon embryos were exposed to culture water contained Sr2+ at Sr2+ concentration of 50, 100, 200 or 400 mg . L-1 for 48 h to imitate Sr2+ sedimentation. After a culturing period of 12 d and 100 d, the otoliths of the chum salmon were taken to detect exogenous Sr2+ sedimentation with electro-probe microanalyzer (EPMA). The results showed that obvious deep red strontium signatures were produced in the otolith of chum salmon at different concentrations of Sr2+. The mean and extreme values of peak strontium area were not stable for the same Sr2+ dose, but the lowest of all the peak values was 35.1 times as much as that of control. Overall, the strontium value increased with the increase of Sr2+concentration. The strontium peak had no signs of abating after a culture period of 100 d. The results also showed that strontium was gradually deposited in the otolith, and had obvious hysteresis to immersion. Strontium sedimentation could also return to a normal level after the peak. These characteristics accorded exactly with the requirement of discharge tag technology, which indicated that exogenous Sr2+ was suitable in the marking of salmon otolith.

  9. Rb-Sr isochrone dating of granitoids from Tribec Mts

    International Nuclear Information System (INIS)

    Bagdasaryan, G.P.; Gukasyan, R.Kh.; Cambel, B.; Broska, I.

    1990-01-01

    The results of Rb-Sr isochrone dating of granitoids from the Tribec-Zobor crystalline complex region are presented. Whole-rock Rb-Sr isochrone indicates an age of 352±5 m.y., the initial ratio being ( 87 Sr/ 86 Sr) 0 =0.70582±0.00008, which approaches the hitherto published initial ratios from the Tatric-Veporide part of the crystalline complex. This indicates a common source of granitoid rocks over the entire region studied. (author). 2 figs., 1 tab., 15 refs

  10. Interplay between HIV Entry and Transportin-SR2 Dependency

    Directory of Open Access Journals (Sweden)

    Gijsbers Rik

    2011-01-01

    Full Text Available Abstract Background Transportin-SR2 (TRN-SR2, TNPO3, transportin 3 was previously identified as an interaction partner of human immunodeficiency virus type 1 (HIV-1 integrase and functions as a nuclear import factor of HIV-1. A possible role of capsid in transportin-SR2-mediated nuclear import was recently suggested by the findings that a chimeric HIV virus, carrying the murine leukemia virus (MLV capsid and matrix proteins, displayed a transportin-SR2 independent phenotype, and that the HIV-1 N74D capsid mutant proved insensitive to transportin-SR2 knockdown. Results Our present analysis of viral specificity reveals that TRN-SR2 is not used to the same extent by all lentiviruses. The DNA flap does not determine the TRN-SR2 requirement of HIV-1. We corroborate the TRN-SR2 independent phenotype of the chimeric HIV virus carrying the MLV capsid and matrix proteins. We reanalyzed the HIV-1 N74D capsid mutant in cells transiently or stably depleted of transportin-SR2 and confirm that the N74D capsid mutant is independent of TRN-SR2 when pseudotyped with the vesicular stomatitis virus glycoprotein (VSV-G. Remarkably, although somewhat less dependent on TRN-SR2 than wild type virus, the N74D capsid mutant carrying the wild type HIV-1 envelope required TRN-SR2 for efficient replication. By pseudotyping with envelopes that mediate pH-independent viral uptake including HIV-1, measles virus and amphotropic MLV envelopes, we demonstrate that HIV-1 N74D capsid mutant viruses retain partial dependency on TRN-SR2. However, this dependency on TRN-SR2 is lost when the HIV N74D capsid mutant is pseudotyped with envelopes mediating pH-dependent endocytosis, such as the VSV-G and Ebola virus envelopes. Conclusion Here we discover a link between the viral entry of HIV and its interaction with TRN-SR2. Our data confirm the importance of TRN-SR2 in HIV-1 replication and argue for careful interpretation of experiments performed with VSV-G pseudotyped viruses in

  11. Enzyme replacement and substrate reduction therapy for Gaucher disease.

    Science.gov (United States)

    Shemesh, Elad; Deroma, Laura; Bembi, Bruno; Deegan, Patrick; Hollak, Carla; Weinreb, Neal J; Cox, Timothy M

    2015-03-27

    Gaucher disease, a rare disorder, is caused by inherited deficiency of the enzyme glucocerebrosidase. It is unique among the ultra-orphan disorders in that four treatments are currently approved by various regulatory authorities for use in routine clinical practice. Hitherto, because of the relatively few people affected worldwide, many of whom started therapy during a prolonged period when there were essentially no alternatives to imiglucerase, these treatments have not been systematically evaluated in studies such as randomized controlled trials now considered necessary to generate the highest level of clinical evidence. To summarize all available randomized controlled study data on the efficacy and safety of enzyme replacement therapies and substrate reduction therapy for treating Gaucher disease. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Inborn Errors of Metabolism Trials Register. Additional searches were conducted on ClinicalTrials.gov for any ongoing studies with potential interim results, and through PubMed. We also searched the reference lists of relevant articles and reviews.Date of last search: 07 August 2014. All randomized and quasi-randomized controlled studies (including open-label studies and cross-over studies) assessing enzyme replacement therapy or substrate reduction therapy, or both, in all types of Gaucher disease were included. Two authors independently assessed the risk of bias in the included studies, and extracted relevant data. Of the 488 studies retrieved by the electronic searches, eight met the inclusion criteria and were analysed (300 participants). Response parameters were restricted to haemoglobin concentration, platelet count, spleen and liver volume and serum biomarkers (chitotriosidase and CCL18). Only one publication reported a 'low risk of bias' score in all parameters assessed, and all studies included were randomized.Four studies reported the responses to enzyme replacement therapy of previously

  12. Trace determination of 90Sr and 89Sr in environmental samples by collinear resonance ionization spectroscopy

    International Nuclear Information System (INIS)

    Lantzsch, J.; Bushaw, B. A.; Bystrow, V. A.; Herrmann, G.; Kluge, H.-J.; Niess, S.; Otten, E. W.; Passler, G.; Schwalbach, R.; Schwarz, M.; Stenner, J.; Trautmann, N.; Wendt, K.; Yushkevich, Y. V.; Zimmer, K.

    1995-01-01

    Collinear resonance ionization spectroscopy has been developed as a sensitive technique for fast trace detection of 90 Sr and 89 Sr in the environment. A detection limit for 90 Sr of 10 7 atoms in the presence of 10 17 atoms in the presence of 10 17 atoms of stable Strontium has been achieved, while the applicability of the method has been demonstrated on real world samples. After collection and chemical separation, strontium is surface ionized, accelerated to 33keV and mass separated. The ions are neutralized and the emerging fast atoms interact with an argon ion laser beam (γ=364 nm) in a quasi-collinear geometry. Optical excitation starts from the long-lived 5s4d 3 D2 state of strontium, which is populated in the charge exchange process, and the fast atoms are selectively excited into the high-lying 5s23f 3 F3 Rydberg state. The Rydberg-atoms are subsequently field-ionized and detected by a channeltron detector after energy selection. The described method was successfully used to determine the 90 Sr-content in air samples collected near Munich during the Chernobyl reactor accident in April 1986

  13. 878787Sr/868686Sr anomalies in Late Cretaceous-Early Tertiary ...

    Indian Academy of Sciences (India)

    paper documents the occurrences of two positive. 87. Sr/. 86 ... Analysis of trace elemental and stable isotopic profiles, sedimentation history ... et al (1980) and report of similar anomalies from ...... through the financial assistance of Alexander von. Humboldt ... and extinction events in earth history; Science 240. 996–1002.

  14. The occurrence and origin of celestite in the Abolfares region, Iran: Implications for Sr-mineralization in Zagros fold belt (ZFB)

    Science.gov (United States)

    Pourkaseb, Houshang; Zarasvandi, Alireza; Rezaei, Mohsen; Mahdavi, Reyhaneh; Ghanavati, Fatemeh

    2017-10-01

    The major celestite deposits in Zagros Fold belt are associated with coastal marine carbonate and evaporate sediments of Oligo-Miocene Asmari and Lower Miocene Ghachsaran Formations. In the Abolfares region, celestite mineralization is extended in the western limb of Bangestan anticline in the carbonates of Early Miocene (middle part of Asmari Formation), underlying by dolomitic carbonates of Burdigalian. From bottom to top three main types of mineralization can be distinguished in the study area: (1) layer texture resulting from replacement of algal limestone by celestite minerals with some parts showing idiomorphic crystals (geodes) along the walls of the cavities, (2) celestite occurrence as irregular massive shape interconnected small crystals and nodules, and (3) celestite mineralization associated with steeply dipping veins and open space fracture fillings, resulting from late-stage epigenetic processes. Highlightly, the ore-hosting carbonate rocks were deposited in an intertidal - supratidal protected setting with hypersaline conditions, in accordance with other celestite deposits of the Zagros Fold belt. The abundance of diagenetic crystallization rhythmites, carbonate and anhydrite inclusions as confirmed by Laser Raman spectroscopy analysis, high Sr/Ba values (average; 8726.1) and strong negative correlations between SO3 vs CaO (R2 = 0.98), SrO vs CaO (R2 = 0.96) with positive correlations between Ba vs SrO (R2 = 0.54) and SO3 vs SrO (R2 = 0.98) highlight the role of high Sr late-diagenetic brines in replacement of carbonates with celestite minerals. It seems that the inception of compressional folding during or soon after the deposition of the Asmari Formation in the carbonate platform at the margin of NW-trending basin in the foreland of the Zagros orogenic belt lead to the upward refluxing of penetrated high-Sr diagenetic brines and celestite mineralization.

  15. Electric field control of the γ-Al2O3/SrTiO3 interface conductivity at room temperature

    DEFF Research Database (Denmark)

    Christensen, Dennis Valbjørn; Trier, Felix; von Soosten, Merlin

    2016-01-01

    Controlling interfaces using electric fields is at the heart of modern electronics. The discovery of the conducting interface between the two insulating oxides LaAlO3 (LAO) and SrTiO3 (STO) has led to a number of interesting electric field-dependent phenomena. Recently, it was shown that replacing...

  16. Replacing lactose from calf milk replacers : effects on digestion and post-absorptive metabolism

    NARCIS (Netherlands)

    Gilbert, M.S.

    2015-01-01

    Summary PhD thesis Myrthe S. Gilbert

    Replacing lactose from calf milk replacers – Effects on digestion and post-absorptive metabolism

    Veal calves are fed milk replacer (MR) and solid feed. The largest part of the energy provided to veal calves

  17. Pipe replacement in a water supply network: coordinated versus uncoordinated replacement and budget effects

    NARCIS (Netherlands)

    Dijk, van D.; Hendrix, E.M.T.

    2016-01-01

    Operators of underground water supply networks are challenged with pipe replacement
    decisions, because pipes are subject to increased failure rates as they age and financial resources
    are often limited.We study the optimal replacement time and optimal number of pipe replacements
    such

  18. A case report: Giant cystic parathyroid adenoma presenting with parathyroid crisis after Vitamin D replacement.

    Science.gov (United States)

    Asghar, Ali; Ikram, Mubasher; Islam, Najmul

    2012-07-28

    Parathyroid adenoma with cystic degeneration is a rare cause of primary hyperparathyroidism. The clinical and biochemical presentation may mimic parathyroid carcinoma. We report the case of a 55 year old lady, who had longstanding history of depression and acid peptic disease. Serum calcium eight months prior to presentation was slightly high, but she was never worked up. She was found to be Vitamin D deficient while being investigated for generalized body aches. A month after she was replaced with Vitamin D, she presented to us with parathyroid crisis. Her corrected serum calcium was 23.0 mg/dL. She had severe gastrointestinal symptoms and acute kidney injury. She had unexplained consistent hypokalemia until surgery. Neck ultrasound and CT scan revealed giant parathyroid cyst extending into the mediastinum. After initial medical management for parathyroid crisis, parathyroid cystic adenoma was surgically excised. Her serum calcium, intact parathyroid hormone, creatinine and potassium levels normalized after surgery. This case of parathyroid crisis, with very high serum calcium and parathyroid hormone levels, is a rare presentation of parathyroid adenoma with cystic degeneration. This case also highlights that Vitamin D replacement may unmask subclinical hyperparathyroidism. Consistent hypokalemia until surgery merits research into its association with hypercalcemia.

  19. Nanostructured transdermal hormone replacement therapy for relieving menopausal symptoms: a confocal Raman spectroscopy study

    Directory of Open Access Journals (Sweden)

    Marco Antonio Botelho

    2014-02-01

    Full Text Available OBJECTIVE: To determine the safety and efficacy of a transdermal nanostructured formulation of progesterone (10% combined with estriol (0.1% + estradiol (0.25% for relieving postmenopausal symptoms. METHODS: A total of 66 postmenopausal Brazilian women with climacteric symptoms of natural menopause received transdermal nanostructured formulations of progesterone and estrogens in the forearm daily for 60 months to mimic the normal ovarian secretory pattern. Confocal Raman spectroscopy of hormones in skin layers was performed. Clinical parameters, serum concentrations of estradiol and follicle-stimulating hormone, blood pressure, BI-RADS classification from bilateral mammography, and symptomatic relief were compared between baseline and 60 months post-treatment. Clinicaltrials.gov: NCT02033512. RESULTS: An improvement in climacteric symptoms was reported in 92.5% of women evaluated before and after 60 months of treatment. The serum concentrations of estradiol and follicle-stimulating hormone changed significantly (p<0.05 after treatment; the values of serum follicle-stimulating hormone decreased after 60 months from 82.04±4.9 to 57.12±4.1 IU/mL. A bilateral mammography assessment of the breasts revealed normal results in all women. No adverse health-related events were attributed to this hormone replacement therapy protocol. CONCLUSION: The nanostructured formulation is safe and effective in re-establishing optimal serum levels of estradiol and follicle-stimulating hormone and relieving the symptoms of menopause. This transdermal hormone replacement therapy may alleviate climacteric symptoms in postmenopausal women.

  20. Nanostructured transdermal hormone replacement therapy for relieving menopausal symptoms: a confocal Raman spectroscopy study

    International Nuclear Information System (INIS)

    Botelho, Marco Antonio; Queiroz, Dinalva Brito; Barros, Gisele; Guerreiro, Stela; Umbelino, Sonia; Lyra, Arao; Borges, Boniek; Freitas, Allan; Almeida, Jackson Guedes; Quintans Junior, Lucindo

    2014-01-01

    Objective:to determine the safety and efficacy of a transdermal nanostructured formulation of progesterone (10%) combined with estriol (0.1%) + estradiol (0.25%) for relieving postmenopausal symptoms. Methods: a total of 66 postmenopausal Brazilian women with climacteric symptoms of natural menopause received transdermal nanostructured formulations of progesterone and estrogens in the forearm daily for 60 months to mimic the normal ovarian secretory pattern. Confocal Raman spectroscopy of hormones in skin layers was performed. Clinical parameters, serum concentrations of estradiol and follicle-stimulating hormone, blood pressure, BI-RADS classification from bilateral mammography, and symptomatic relief were compared between baseline and 60 months post-treatment. Clinicaltrials.gov: NCT02033512. Results: an improvement in climacteric symptoms was reported in 92.5% of women evaluated before and after 60 months of treatment. The serum concentrations of estradiol and follicle-stimulating hormone changed significantly (p<0.05) after treatment; the values of serum follicle-stimulating hormone decreased after 60 months from 82.04 ± 4.9 to 57.12 ± 4.1 IU/mL. A bilateral mammography assessment of the breasts revealed normal results in all women. No adverse health-related events were attributed to this hormone replacement therapy protocol. Conclusion: the nanostructured formulation is safe and effective in re-establishing optimal serum levels of estradiol and follicle-stimulating hormone and relieving the symptoms of menopause. This transdermal hormone replacement therapy may alleviate climacteric symptoms in postmenopausal women. (author)

  1. Nanostructured transdermal hormone replacement therapy for relieving menopausal symptoms: a confocal Raman spectroscopy study

    Energy Technology Data Exchange (ETDEWEB)

    Botelho, Marco Antonio; Queiroz, Dinalva Brito; Barros, Gisele; Guerreiro, Stela; Umbelino, Sonia; Lyra, Arao; Borges, Boniek; Freitas, Allan, E-mail: marcobotelho@pq.cnpq.br [Universidade Potiguar, Natal, RN (Brazil). Lab. de Nanotecnologia; Fechine, Pierre [Universidade Federal do Ceara (GQMAT/UFCE), Fortaleza, CE (Brazil). Dept. de Quimica Analitica. Grupo Avancado de Biomateriais em Quimica; Queiroz, Danilo Caldas de [Instituto Federal de Ciencia e Tecnologia (IFCT), Fortaleza, CE (Brazil). Lab. de Biotecnologia; Ruela, Ronaldo [Instituto de Biotecnologia Aplicada (INBIOS), Fortaleza, CE (Brazil); Almeida, Jackson Guedes [Universidade Federal do Vale de Sao Francisco (UNIVALE), Petrolina, PE (Brazil). Fac. de Ciencias Farmaceuticas; Quintans Junior, Lucindo [Universidade Federal de Sergipe (UFSE), Sao Cristovao, SE (Brazil). Dept. de Fisiologia

    2014-06-01

    Objective:to determine the safety and efficacy of a transdermal nanostructured formulation of progesterone (10%) combined with estriol (0.1%) + estradiol (0.25%) for relieving postmenopausal symptoms. Methods: a total of 66 postmenopausal Brazilian women with climacteric symptoms of natural menopause received transdermal nanostructured formulations of progesterone and estrogens in the forearm daily for 60 months to mimic the normal ovarian secretory pattern. Confocal Raman spectroscopy of hormones in skin layers was performed. Clinical parameters, serum concentrations of estradiol and follicle-stimulating hormone, blood pressure, BI-RADS classification from bilateral mammography, and symptomatic relief were compared between baseline and 60 months post-treatment. Clinicaltrials.gov: NCT02033512. Results: an improvement in climacteric symptoms was reported in 92.5% of women evaluated before and after 60 months of treatment. The serum concentrations of estradiol and follicle-stimulating hormone changed significantly (p<0.05) after treatment; the values of serum follicle-stimulating hormone decreased after 60 months from 82.04 ± 4.9 to 57.12 ± 4.1 IU/mL. A bilateral mammography assessment of the breasts revealed normal results in all women. No adverse health-related events were attributed to this hormone replacement therapy protocol. Conclusion: the nanostructured formulation is safe and effective in re-establishing optimal serum levels of estradiol and follicle-stimulating hormone and relieving the symptoms of menopause. This transdermal hormone replacement therapy may alleviate climacteric symptoms in postmenopausal women. (author)

  2. Shape coexistence and evolution in 98Sr

    Science.gov (United States)

    Park, J.; Garnsworthy, A. B.; Krücken, R.; Andreoiu, C.; Ball, G. C.; Bender, P. C.; Chester, A.; Close, A.; Finlay, P.; Garrett, P. E.; Glister, J.; Hackman, G.; Hadinia, B.; Leach, K. G.; Rand, E. T.; Sjue, S.; Starosta, K.; Svensson, C. E.; Tardiff, E.

    2016-01-01

    Shape coexistence between the strongly deformed ground state and the weakly deformed 02+ state in 98Sr has been a major topic of interest due to the energy difference of 215 keV, which is the smallest in all even-even nuclei. The electric monopole transition strength ρ2(E 0 ) is an important quantity that can relate the deformation difference and the shape mixing between the two 0+ states, which are admixtures of the vibrational (S) and the rotational (D) states in a simple mixing model. In a β -decay spectroscopy experiment, the experimental ρ2(E 0 ) was measured. A value of 0.053(5) is consistent with the previous measurement and was combined with known electric quadrupole transition strengths B (E 2 ) in calculations of a two-state mixing model. Based on a systematic study on neighboring Kr, Zr, and Mo isotopes, the mixing of the 0+ and 2+ states in 98Sr was determined to be 8.6% and 1.3%, respectively, corresponding to deformation parameters βD=0.38 (1 ) and βS=-0.23 (2 ) . These parameters reproduce experimental transition strengths well except for the 41+→21+ transition, which suggests a smaller D-band deformation for J ≥4 .

  3. [Application of continuous renal replacement therapy in the treatment of myonephropathic metabolic syndrome caused by acute lower extremity ischemia].

    Science.gov (United States)

    Sun, Jianping; Wang, Tengke; Zhang, Jinglan

    2014-09-16

    To summarize the experiences of using continuous renal replacement therapy in the treatment of myonephropathic metabolic syndrome caused by acute lower limb ischemia. Retrospective study of patients diagnosed acute lower limb ischemia with surgical treatment between January 2008 and December 2013, among which 22 patients with myonephropathic metabolic syndrome received continuous renal replacement therapy. Summarize the change tendency of myoglobin, urine volume and serum creatinine levels during treatment and analysis the condition changes and prognosis of the patients. Among them, 2 patients were amputated and two died after surgery. The major causes of death were acute renal failure, metabolic acidosis, circulation failure and liver failure, etc. Myoglobin was significantly higher at Day 1 after surgery than that was before surgery (P metabolic syndrome, early targeted continuous renal replacement therapy may decrease the serum concentrations of myoglobin and CK, improve urine volume, maintain homeostasis, prevent renal function deterioration and improve the prognosis of patients. And it is highly recommended.

  4. Size exclusion chromatography for semipreparative scale separation of Au38(SR)24 and Au40(SR)24 and larger clusters.

    Science.gov (United States)

    Knoppe, Stefan; Boudon, Julien; Dolamic, Igor; Dass, Amala; Bürgi, Thomas

    2011-07-01

    Size exclusion chromatography (SEC) on a semipreparative scale (10 mg and more) was used to size-select ultrasmall gold nanoclusters (<2 nm) from polydisperse mixtures. In particular, the ubiquitous byproducts of the etching process toward Au(38)(SR)(24) (SR, thiolate) clusters were separated and gained in high monodispersity (based on mass spectrometry). The isolated fractions were characterized by UV-vis spectroscopy, MALDI mass spectrometry, HPLC, and electron microscopy. Most notably, the separation of Au(38)(SR)(24) and Au(40)(SR)(24) clusters is demonstrated.

  5. Design verification for reactor head replacement

    International Nuclear Information System (INIS)

    Dwivedy, K.K.; Whitt, M.S.; Lee, R.

    2005-01-01

    This paper outlines the challenges of design verification for reactor head replacement for PWR plants and the program for qualification from the prospective of the utility design engineering group. This paper is based on the experience with the design confirmation of four reactor head replacements for two plants, and their interfacing components, parts, appurtenances, and support structures. The reactor head replacement falls under the jurisdiction of the applicable edition of the ASME Section XI code, with particular reference to repair/replacement activities. Under any repair/replacement activities, demands may be encountered in the development of program and plan for replacement due to the vintage of the original design/construction Code and the design reports governing the component qualifications. Because of the obvious importance of the reactor vessel, these challenges take on an added significance. Additional complexities are introduced to the project, when the replacement components are fabricated by vendors different from the original vendor. Specific attention is needed with respect to compatibility with the original design and construction of the part and interfacing components. The program for reactor head replacement requires evaluation of welding procedures, applicable examination, test, and acceptance criteria for material, welds, and the components. Also, the design needs to take into consideration the life of the replacement components with respect to the extended period of operation of the plant after license renewal and other plant improvements. Thus, the verification of acceptability of reactor head replacement provides challenges for development and maintenance of a program and plan, design specification, design report, manufacturer's data report and material certification, and a report of reconciliation. The technical need may also be compounded by other challenges such as widely scattered global activities and organizational barriers, which

  6. Delirium After Transcatheter Aortic Valve Replacement.

    Science.gov (United States)

    Giuseffi, Jennifer L; Borges, Nyal E; Boehm, Leanne M; Wang, Li; McPherson, John A; Fredi, Joseph L; Ahmad, Rashid M; Ely, E Wesley; Pandharipande, Pratik P

    2017-07-01

    Postoperative delirium is associated with increased mortality. Patients undergoing transcatheter aortic valve replacement are at risk for delirium because of comorbid conditions. To compare the incidence, odds, and mortality implications of delirium between patients undergoing transcatheter replacement and patients undergoing surgical replacement. The Richmond Agitation-Sedation Scale and the Confusion Assessment Method for the Intensive Care Unit were used to assess arousal level and delirium prospectively in all patients with severe aortic stenosis who had transcatheter or surgical aortic valve replacement at an academic medical center. Multivariable logistic regression was used to determine the relationship between procedure type and occurrence of delirium. Cox regression was used to assess the association between postoperative delirium and 6-month mortality. A total of 105 patients had transcatheter replacement and 121 had surgical replacement. Patients in the transcatheter group were older (median age, 81 vs 68 years; P replacement. Delirium is less likely to develop in the transcatheter group but is associated with higher mortality in both groups. ©2017 American Association of Critical-Care Nurses.

  7. Optimal composition of fluid-replacement beverages.

    Science.gov (United States)

    Baker, Lindsay B; Jeukendrup, Asker E

    2014-04-01

    The objective of this article is to provide a review of the fundamental aspects of body fluid balance and the physiological consequences of water imbalances, as well as discuss considerations for the optimal composition of a fluid replacement beverage across a broad range of applications. Early pioneering research involving fluid replacement in persons suffering from diarrheal disease and in military, occupational, and athlete populations incurring exercise- and/or heat-induced sweat losses has provided much of the insight regarding basic principles on beverage palatability, voluntary fluid intake, fluid absorption, and fluid retention. We review this work and also discuss more recent advances in the understanding of fluid replacement as it applies to various populations (military, athletes, occupational, men, women, children, and older adults) and situations (pathophysiological factors, spaceflight, bed rest, long plane flights, heat stress, altitude/cold exposure, and recreational exercise). We discuss how beverage carbohydrate and electrolytes impact fluid replacement. We also discuss nutrients and compounds that are often included in fluid-replacement beverages to augment physiological functions unrelated to hydration, such as the provision of energy. The optimal composition of a fluid-replacement beverage depends upon the source of the fluid loss, whether from sweat, urine, respiration, or diarrhea/vomiting. It is also apparent that the optimal fluid-replacement beverage is one that is customized according to specific physiological needs, environmental conditions, desired benefits, and individual characteristics and taste preferences.

  8. Optimum body size of Holstein replacement heifers.

    Science.gov (United States)

    Hoffman, P C

    1997-03-01

    Criteria that define optimum body size of replacement heifers are required by commercial dairy producers to evaluate replacement heifer management programs. Historically recommended body size criteria have been based on live BW measurements. Numerous research studies have observed a positive relationship between BW at first calving and first lactation milk yield, which has served as the impetus for using live BW to define body size of replacement heifers. Live BW is, however, not the only available measurement to define body size. Skeletal measurements such as wither height, length, and pelvic area have been demonstrated to be related to first lactation performance and (or) dystocia. Live BW measurements also do not define differences in body composition. Differences in body composition of replacement heifers at first calving are also related to key performance variables. An updated research data base is available for the modern Holstein genotype to incorporate measures of skeletal growth and body composition with BW when defining body size. These research projects also lend insight into the relative importance of measurements that define body size of replacement heifers. Incorporation of these measurements from current research into present BW recommendations should aid commercial dairy producers to better define replacement heifer growth and management practices. This article proposes enhancements in defining optimum body size and growth characteristics of Holstein replacement heifers.

  9. Defect engineering of SrTiO{sub 3} thin films for resistive switching applications

    Energy Technology Data Exchange (ETDEWEB)

    Wicklein, Sebastian

    2013-11-19

    As a matter of fact, the importance of (transition) metal oxides for modern applications in the field of energy and information technology (IT) for e.g. novel energy storage systems and solid state electronic devices is increasing. Previous studies discovered the importance of defects in an oxide for their functionality and emphasized the impact of stoichiometry on the oxide performance. A new field of interest of the memory technology sector is the so-called resistive switching phenomena where a voltage stimulus causes a thin oxide (≤10 nm) to change its resistance state from a high resistance state to a low resistance state and back. So called resistive RAM (ReRAM or RRAM) are deemed to be the future replacement (2015) for contemporary FLASH memory technology due to its extremely low energy consumption, its very fast read/write time (ns) and its possible node size <10 nm. A key challenge for the investigation of oxides and their electronic properties is the management and controlled incorporation of defects in the thin film oxide. Within this work, SrTiO{sub 3} was used as an oxide model material and was deposited by pulsed laser deposition (PLD) onto doped and undoped SrTiO{sub 3} single crystals to investigate the formation of defects as a function of the process parameters. By combining structural and chemical thin film analysis with detailed PLD plume diagnostics and modeling of the laser plume dynamics, it was possible to elucidate the different physical mechanisms determining the stoichiometry of SrTiO{sub 3} during PLD. Deviations between thin film and target stoichiometry are basically a result of two effects, namely, incongruent ablation and preferential scattering of lighter ablated species during their motion towards the substrate in the O{sub 2} background gas. It is shown that the SrTiO{sub 3} system reacts to a non-stoichiometry with the systematic incorporation of titanium and strontium vacancies which could be detected by positron annihilation

  10. The effect of growth hormone replacement on the thyroid axis in patients with hypopituitarism: in vivo and ex vivo studies.

    Science.gov (United States)

    Glynn, Nigel; Kenny, Helena; Quisenberry, Leah; Halsall, David J; Cook, Paul; Kyaw Tun, Tommy; McDermott, John H; Smith, Diarmuid; Thompson, Christopher J; O'Gorman, Donal J; Boelen, Anita; Lado-Abeal, Joaquin; Agha, Amar

    2017-05-01

    Alterations in the hypothalamic-pituitary-thyroid axis have been reported following growth hormone (GH) replacement. The aim was to examine the relationship between changes in serum concentration of thyroid hormones and deiodinase activity in subcutaneous adipose tissue, before and after GH replacement. A prospective, observational study of patients receiving GH replacement as part of routine clinical care. Twenty adult hypopituitary men. Serum TSH, thyroid hormones - free and total thyroxine (T4) and triiodothyronine (T3) and reverse T3, thyroglobulin and thyroid-binding globulin (TBG) levels were measured before and after GH substitution. Changes in serum hormone levels were compared to the activity of deiodinase isoenzymes (DIO1, DIO2 and DIO3) in subcutaneous adipose tissue. The mean daily dose of growth hormone (GH) was 0·34 ± 0·11 mg (range 0·15-0·5 mg). Following GH replacement, mean free T4 levels declined (-1·09 ± 1·99 pmol/l, P = 0·02). Reverse T3 levels also fell (-3·44 ± 1·42 ng/dl, P = 0·03) and free T3 levels increased significantly (+0·34 ± 0·15 pmol/l, P = 0·03). In subcutaneous fat, DIO2 enzyme activity declined; DIO1 and DIO3 activities remained unchanged following GH substitution. Serum TSH, thyroglobulin and TBG levels were unaltered by GH therapy. In vitro analysis of subcutaneous adipose tissue from hypopituitary human subjects demonstrates that GH replacement is associated with significant changes in deiodinase isoenzyme activity. However, the observed variation in enzyme activity does not explain the changes in the circulating concentration of thyroid hormones induced by GH replacement. It is possible that deiodinase isoenzymes are differentially regulated by GH in other tissues including liver and muscle. © 2016 John Wiley & Sons Ltd.

  11. Luminescence properties of Eu2+-doped MAl2-xSixO4-xNx (M = Ca, Sr, Ba) conversion phosphor for white LED applications

    NARCIS (Netherlands)

    Li, Y.Q.; With, de G.; Hintzen, H.T.J.M.

    2006-01-01

    Undoped and Eu-doped MAl2-xSixO4-2Nx (M = Ca, Sr, Ba) were synthesized by a solid-state reaction method at 1300 - 1400 ¿C under nitrogen-hydrogen atmosphere. The solubility of (SiN)+, in MAl2O4 was determined. Nitrogen can be incorporated into MAl2O4 by replacement of (AlO)+ by (SiN)+, whose amount

  12. Measurement Differences Between Two Immunoassay Systems for LH and FSH: A Comparison of Roche Cobas e601 vs. Abbott Architect i2000sr.

    Science.gov (United States)

    Yin, Lianli; Tang, Yinghua; Chen, Xiang; Sun, Yifan

    2018-03-01

    Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) regulate the growth and reproductive activity of gonadal tissue and determine the concentration of LH is essential for the prediction of ovulation. Collectively, FSH and LH are important measurements to ascertain the causes of infertility as well as diagnosing disorders such as polycystic ovary syndrome and pituitary and gonadal dysfunction. This study compares the correlation between LH and FSH measurements during examination with two different systems, Architect i2000sr (Abbott Laboratories; Lake Bluff, IL, USA) and Cobas e601 (Roche; Geneva, Switzerland), and assesses the differences between these systems. Serum analysis was performed for 95 patients using both the Cobas e601 and Architect i2000sr systems. The method used to compare the systems was Passing-Bablok regression analysis with a Bland-Altman agreement plot. Inter-rater agreement was analyzed using a concordance correlation coefficient. Architect i2000sr and Cobas e601 have strong correlations in their LH and FSH results. However, the Bland-Altman plot shows that LH and FSH measurements in Cobas e601 are about 1.31 times and 1.26 times higher than those in Architect i2000sr, respectively. Passing-Bablok regression analysis also shows significant proportional deviation between them. The difference between the test results for LH and FSH in Cobas e601 and Architect i2000sr indicate that the results from one system cannot be directly used to evaluate the other system.

  13. How to replace a reactor pressure vessel

    International Nuclear Information System (INIS)

    Huber, R.

    1996-01-01

    A potential life extending procedure for a nuclear reactor after, say, 40 years of service life, might in some circumstances be the replacement of the reactor pressure vessel. Neutron induced degradation of the vessel might make replacement by one of a different material composition desirable, for example. Although the replacement of heavy components, such as steam generators, has been possible for many years, the pressure vessel presents a much more demanding task if only because it is highly irradiated. Some preliminary feasibility studies by Siemens are reported for the two removal strategies that might be considered. These are removal of the entire pressure vessel in one piece and dismantling it into sections. (UK)

  14. Conceptual Design Plan SM-43 Replacement Project

    Energy Technology Data Exchange (ETDEWEB)

    University of California, Los Alamos National Laboratory, SCC Project Office

    2000-11-01

    The Los Alamos National Laboratory Conceptual Design Plan for the SM-43 Replacement Project outlines plans for replacing the SM-43 Administration Building. Topics include the reasons that replacement is considered a necessity; the roles of the various project sponsors; and descriptions of the proposed site and facilities. Also covered in this proposal is preliminary information on the project schedule, cost estimates, acquisition strategy, risk assessment, NEPA strategy, safety strategy, and safeguards and security. Spreadsheets provide further detail on space requirements, project schedules, and cost estimates.

  15. Self-propagating high-temperature synthesis of Sr-doped LaMnO3 perovskite as oxidation catalyst

    International Nuclear Information System (INIS)

    Hirano, T.; Purwanto, H.; Watanabe, T.; Akiyama, T.

    2007-01-01

    Sr-doped LaMnO 3 perovskite oxide has been focused on as one of the alternative catalysts to precious metals such as platinum that are used for cleaning automotive emission gas. The conventional Solid-state reaction method is a popular productive process for perovskite oxide, however, it is time and energy consuming process because it requires repeated prolonged heat treatment at high temperatures. Therefore, the purposes of this work are to produce Sr-doped LaMnO 3 perovskite by using Self-propagating high-temperature synthesis (SHS) and experimentally examine the oxidation catalytic activity of the product for cleaning automotive emission gas. In the SHS, powders of La 2 O 3 , SrCO 3 , Mn and NaClO 4 were well mixed at the desired ratio and poured in a graphite crucible, where at one end it was ignited by using an electrically heated carbon foil. The wave of exothermic reaction due to oxidation of manganese propagated to the other end in a short time. The obtained products were characterized by means of XRD, FE-SEM, BET and particle size distribution analysis and then evaluated via catalytic oxidation tests by using propane in a fixed bed reactor at several temperatures. From the XRD analysis, the products had the desired composition of La 1-x Sr x MnO 3 (x = 0, 0.1, 0.2 and 0.4) perovskite, in which the replacing ratio x of La and Sr in the products was easily controlled by changing the mixing ratio of raw materials. The catalytic activity test showed that the samples exhibited good catalytic activity for propane oxidation over 200 deg. C , although the products had a relatively small surface area. SHS showed the potential for the production of a relatively inexpensive catalytic converter

  16. Study of Serum Amylase and Serum Cholinesterase in Organophosphorus Poisoning

    Directory of Open Access Journals (Sweden)

    Sharan Badiger

    2016-04-01

    Full Text Available Background: Poisoning due to organophosphorus compounds is most commonly seen. Earlier plasma cholinesterase level was used to assess the severity of poisoning. Presently serum amylase is being recommended as a better indicator of severity. Aims and Objectives: To study plasma cholinesterase and serum amylase levels in acute organophosphorus and to correlate serum amylase levels with clinical severity and outcome. Material and Methods: A total of 80 patients in the study admitted to a tertiary care centre within 24 hours with a history of organophosphorus poisoning were included in study. Estimation of plasma cholinesterase and serum rd amylase was done at the time of admission, and on 3 th day and on 5 day. Results: Occurrence of organophosphorus poisoning was more common among age group 21-30 years and among males (57.5%. They were 25 (31.2% farmers, 23 (28.8% st u d e n ts, a n d 2 2 ( 2 7 . 5% h o u s ewi v e s. Monocrotophos (45.0% was commonly used compound. Mean value of plasma cholinesterase and serum amylase at admission are 3693 U/L, and 185.4 U/L. There was significant inhibition of plasma cholinesterase and elevation of serum amylase at th admission with return to normal values on 5 day. Conclusion: Plasma cholinesterase inhibition 200 U/L has been associated with poor prognosis and proneness to respiratory failure.

  17. Thermal infrared and microwave absorbing properties of SrTiO3/SrFe12O19/polyaniline nanocomposites

    International Nuclear Information System (INIS)

    Hosseini, Seyed Hossein; Zamani, Parisa; Mousavi, S.Y.

    2015-01-01

    Graphical abstract: We have developed a new perspective of applications and properties of conducting polymers. The combination of absorption ability prepared nanocomposites in the present of PANI display a great potential in organization of shielding structures into thermal IR and microwave. Further investigations using other conducting polymers to demonstrate their capability for advance thermal IR and microwave shielding devices is under way. The application of these samples may improve the IR thermographic detection, catalysis, sensors, magnetic data storage, electromagnetic resonance wave absorption, photonic crystals, and microelectronic devices and military aspects. - Highlights: • The SrTiO 3 /SrFe 12 O 19 /PANI exhibited electric and electromagnetic properties. • The SrTiO 3 /SrFe 12 O 19 /PANI has shielding structures into thermal IR and microwave. • Increasing weight ratios and thicknesses will increase thermal IR ability. • Increasing weight ratios and thicknesses will increase microwave absorption ability. - Abstract: Polyaniline (PANI) as a unique polymer that also has electromagnetic absorption used as the substrate. In this research, SrTiO 3 was synthesized as IR absorbent and core and then SrFe 12 O 19 as microwave absorbent was prepared on SrTiO 3 via co-precipitation method as the first shell. As the next step, PANI was coated on SrTiO 3 /SrFe 12 O 19 nanoparticles via in situ polymerization by multi core–shell structures (SrTiO 3 /SrFe 12 O 19 /PANI). Nanometer size and structures of samples were measured by TEM, XRD and FTIR. Morphology of nanocomposite was showed by SEM images. The magnetic and electric properties were also performed by VSM and four probe techniques. Thermal infrared (IR) absorption and microwave reflection loss of nanocomposites were investigated at 10–40 μm and 8–12 GHz, IR and microwave frequencies, respectively. The results showed that the SrTiO 3 /SrFe 12 O 19 /PANI nanocomposites have good compatible

  18. On the μSR activity at LNP JINR phasotron

    International Nuclear Information System (INIS)

    Gurevich, I.I.; Duginov, V.N.; Firsov, V.G.

    1992-01-01

    The current state of μSR activity at LNR JINR phasotron is presented, including short description of experimental facilities. The possible trends of μSR investigation for future work are outlined. The list of main publications (1987-1992) is included. 35 refs.; 1 fig

  19. OpenNebula KVM SR-IOV driver

    CSIR Research Space (South Africa)

    Macleod, D

    2013-05-01

    Full Text Available With the recent release of an OFED which supports SR-IOV on Infiniband HCAs it is now possible to use verbs from inside a VM. This VMM driver supports these Infiniband HCAs, and any other SR-IOV network device, in OpenNebula....

  20. Thermodynamic modeling of the Sr-Co-Fe-O system

    DEFF Research Database (Denmark)

    Zhang, Wei Wei; Povoden-Karadeniz, Erwin; Chen, Ming

    2016-01-01

    This paper reviews and assesses phase equilibria and thermodynamic properties of phases in the Sr-Co-Fe-O system, with a focus on oxides, especially the SrCo1 - xFexO3 - δ perovskite. In our work, the SrCo1 - xFexO3 - δ perovskite was modeled with a three-sublattice model, where the three...... sublattices correspond to the A, B and oxygen sites in an ABO3 perovskite, respectively. A number of other important ternary oxide phases in Sr-Co-O and Sr-Co-Fe-O were also considered. Available thermodynamic and phase diagram data were carefully assessed. A thermodynamic description of Sr-Co-O was derived...... using the CALPHAD approach and was further extrapolated to that of Sr-Co-Fe-O. The thermodynamic database of Sr-Co-Fe-O established in this work allows for calculating phase diagrams, thermodynamic properties, cation distribution and defect chemistry properties, and therefore enables material...

  1. ) m /SrVO3 ( m = 5, 6) Superlattices

    KAUST Repository

    Dai, Qingqing; Lü ders, Ulrike; Fré sard, Raymond; Eckern, Ulrich; Schwingenschlö gl, Udo

    2018-01-01

    The (LaV3+O3)m/SrV4+O3 (m = 5, 6) superlattices are investigated by first principles calculations. While bulk LaVO3 is a C‐type antiferromagnetic semiconductor and bulk SrVO3 is a paramagnetic metal, semiconducting A‐type antiferromagnetic states

  2. Determination of 90Sr from aqueous solutions using SPE extraction

    International Nuclear Information System (INIS)

    Dulanska, S.; Rajec, P.; Matel, L.

    2008-01-01

    Solid Phase Extraction (SPE) is widely used technique for the isolation and concentration of analytes from liquid samples to achieve increased sensitivity in the analytical process. Three commercial sorbents produced by three different manufacturers were tested. 3M Empore TM Strontium Rad Disks, Sr resin and AnaLig Sr-01 were used to efficiently isolate strontium from aqueous samples. (authors)

  3. Geosphere process report for the safety assessment SR-Site

    International Nuclear Information System (INIS)

    Skagius, Kristina

    2010-11-01

    This report documents geosphere processes identified as relevant to the long-term safety of a KBS-3 repository, and forms an important part of the reporting of the safety assessment SR-Site. The detailed assessment methodology, including the role of the process reports in the assessment, is described in the SR-Site Main report /SKB 2011/

  4. Geosphere process report for the safety assessment SR-Site

    Energy Technology Data Exchange (ETDEWEB)

    Skagius, Kristina (ed.) (Kemakta Konsult AB, Stockholm (Sweden))

    2010-11-15

    This report documents geosphere processes identified as relevant to the long-term safety of a KBS-3 repository, and forms an important part of the reporting of the safety assessment SR-Site. The detailed assessment methodology, including the role of the process reports in the assessment, is described in the SR-Site Main report /SKB 2011/

  5. The study of accumulation of Sr 90 by plant cells

    International Nuclear Information System (INIS)

    Matusov, G.D.; Kudryashova, N.N.

    2002-01-01

    In this work the absorption and desorption of ions Sr 90 by plant cells and influence of different physical and chemical factors of environment on that processes were investigated. The kinetics of strontium accumulation have been obtained and the factors of accumulation of Sr 90 have been determined for a plant cell itself and its separate compartments

  6. Sr-90 determination in aqueous and soils samples

    International Nuclear Information System (INIS)

    Gonzalez Sintas, Maria F.; Cerchietti, Maria L.; Arguelles, Maria G.

    2009-01-01

    The main objective of this paper is to evaluate the method for Sr-90 determination in aqueous sample and soils. Area and Personal Dosimetry laboratory (DPA) determines the presence of Sr-90 by Liquid Scintillation (LSC) by applying method of the double window and corresponding adjustments. Calibration is performed by standard solutions of 90 Sr/ 90 Y, where spectral 90 Sr and 90 Y zones are optimized. The initial treatment of the liquid samples includes the concentration for evaporation, while the solid ones dissolve for microwave and acidic digestion. The separation of the analyte involves a selective chromatographic extraction. An average efficiency for 90 Sr of 77 ± 1 % was obtained; the factor a/b was 0,85 ± 0,01 and recovery of 82 ± 8 %. The resultant MAD was 0,10 Bq/L in aqueous samples and 0,10 Bq/g in solid samples. (author)

  7. Effect of SrO content on Zeolite Structure

    Science.gov (United States)

    Widiarti, N.; Sari, U. S.; Mahatmanti, F. W.; Harjito; Kurniawan, C.; Prasetyoko, D.; Suprapto

    2018-04-01

    The aims of current studies is to investigate the effect of strontium oxide content (SrO) on synthesized zeolite. Zeolite was synthesized from Tetraethyl orthosilicate (TEOS) as precursors of SiO2 and aluminum isopropoxide (AIP) precursors. The mixture was aged for 3 days and hydrothermally treated for 6 days. The SrO content was added by impregnation method. The products were then characterized using X-Ray Diffraction (XRD), Fourier Transform Infrared (FTIR), and Surface Area Analyzer (SAA). The diffractogram confirmed the formation of Faujasite-like zeolite. However, after the addition of SrO, the crystallinity of zeolite was deformed. The diffractograms shows the amorphous phase of zeolite were decrease as the SrO content is increase. The structural changes was also observed from FTIR spectra which shows the shifting and peak formation. The surface area analysis showed that the increasing loading of SrO/Zeolites reduced the catalyst surface area.

  8. Geographical distribution of 90Sr contamination in Poland

    International Nuclear Information System (INIS)

    Gaca, P.; Mietelski, J.W.; Skwarzec, B.

    2006-01-01

    The paper presents results on determination of 90 Sr in bilberry and cowberry leaves (Vaccinium myrtillus and Vaccinium vitis-idaea) and the use of these plants as bio-monitors of radiostrontium contamination in Poland. Radiostrontium was determined by mean of liquid scintillation spectrometry preceded by radiochemical separation using Sr-resin and 85 Sr tracer. The approximate map of 90 Sr contamination of Poland is presented. The activity ratio between 90 Sr and obtained earlier data for 137 Cs in the same samples is discussed. The enhancement of radiostrontium content observed in northeastern Poland seems to be the trace of hot-particles fallout from initial Chernobyl cloud, which passed over Polish territory toward Scandinavia. (orig.)

  9. Targeting SR-BI for cancer diagnostics, imaging and therapy

    Directory of Open Access Journals (Sweden)

    Maneesha Amrita Rajora

    2016-09-01

    Full Text Available Scavenger receptor class B type I (SR-BI plays an important role in trafficking cholesteryl esters between the core of high density lipoprotein and the liver. Interestingly, this integral membrane protein receptor is also implicated in the metabolism of cholesterol by cancer cells, whereby overexpression of SR-BI has been observed in a number of tumours and cancer cell lines, including breast and prostate cancers. Consequently, SR-BI has recently gained attention as a cancer biomarker and exciting target for the direct cytosolic delivery of therapeutic agents. This brief review highlights these key developments in SR-BI-targeted cancer therapies and imaging probes. Special attention is given to the exploration of high density lipoprotein nanomimetic platforms that take advantage of upregulated SR-BI expression to facilitate targeted drug-delivery and cancer diagnostics, and promising future directions in the development of these agents.

  10. Resistance switching in epitaxial SrCoOx thin films

    Science.gov (United States)

    Tambunan, Octolia T.; Parwanta, Kadek J.; Acharya, Susant K.; Lee, Bo Wha; Jung, Chang Uk; Kim, Yeon Soo; Park, Bae Ho; Jeong, Huiseong; Park, Ji-Yong; Cho, Myung Rae; Park, Yun Daniel; Choi, Woo Seok; Kim, Dong-Wook; Jin, Hyunwoo; Lee, Suyoun; Song, Seul Ji; Kang, Sung-Jin; Kim, Miyoung; Hwang, Cheol Seong

    2014-08-01

    We observed bipolar switching behavior from an epitaxial strontium cobaltite film grown on a SrTiO3 (001) substrate. The crystal structure of strontium cobaltite has been known to undergo topotactic phase transformation between two distinct phases: insulating brownmillerite (SrCoO2.5) and conducting perovskite (SrCoO3-δ) depending on the oxygen content. The current-voltage characteristics of the strontium cobaltite film showed that it could have a reversible insulator-to-metal transition triggered by electrical bias voltage. We propose that the resistance switching in the SrCoOx thin film could be related to the topotactic phase transformation and the peculiar structure of SrCoO2.5.

  11. Resistance switching in epitaxial SrCoOx thin films

    International Nuclear Information System (INIS)

    Tambunan, Octolia T.; Parwanta, Kadek J.; Acharya, Susant K.; Lee, Bo Wha; Jung, Chang Uk; Kim, Yeon Soo; Park, Bae Ho; Jeong, Huiseong; Park, Ji-Yong; Cho, Myung Rae; Park, Yun Daniel; Choi, Woo Seok; Kim, Dong-Wook; Jin, Hyunwoo; Lee, Suyoun; Song, Seul Ji; Kang, Sung-Jin; Kim, Miyoung; Hwang, Cheol Seong

    2014-01-01

    We observed bipolar switching behavior from an epitaxial strontium cobaltite film grown on a SrTiO 3 (001) substrate. The crystal structure of strontium cobaltite has been known to undergo topotactic phase transformation between two distinct phases: insulating brownmillerite (SrCoO 2.5 ) and conducting perovskite (SrCoO 3−δ ) depending on the oxygen content. The current–voltage characteristics of the strontium cobaltite film showed that it could have a reversible insulator-to-metal transition triggered by electrical bias voltage. We propose that the resistance switching in the SrCoO x thin film could be related to the topotactic phase transformation and the peculiar structure of SrCoO 2.5

  12. Replacement Saltwell Pumping System Document Bibliography

    International Nuclear Information System (INIS)

    BELLOMY, J.R.

    2000-01-01

    This document bibliography is prepared to identify engineering documentation developed during the design of the Replacement Saltwell Pumping System. The bibliography includes all engineering supporting documents and correspondence prepared prior to the deployment of the system in the field. All documents referenced are available electronically through the Records Management Information System (RMIS). Major components of the Replacement Saltwell Pumping System include the Sundyne Canned Motor Pump, the Water Filter Skid, the Injection Water Skid and the Backflow Preventer Assembly. Drawing H-14-104498 provides an index of drawings (fabrication details, PandIDs, etc.) prepared to support development of the Replacement Saltwell Pumping System. Specific information pertaining to new equipment can be found in Certified Vendor Information (CVI) File 50124. This CVI file has been established specifically for new equipment associated with the Replacement Saltwell Pumping System

  13. The future of rapid bridge deck replacement.

    Science.gov (United States)

    2015-06-01

    Replacing aging, deteriorated infrastructure often requires road closures and traffic detours which impose : inconvenience and delay on commerce and members of the motoring public. Accelerated bridge construction : techniques often use precast member...

  14. Proper Installation of Replacement Windows | Efficient Windows

    Science.gov (United States)

    Collaborative Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring

  15. Assessing Window Replacement Options | Efficient Windows Collaborative

    Science.gov (United States)

    Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

  16. Logistic Vehicle System Replacement Cost Estimate

    National Research Council Canada - National Science Library

    Stinson, Margaret

    1998-01-01

    The Logistics Vehicle System (LVS) was originally fielded from 1985-1989. Most of the LVS fleet will reach end-of-service life in 2005, therefore the goal of the Logistics Vehicle System Replacement (LVSR...

  17. Steam-generator replacement sets new marks

    International Nuclear Information System (INIS)

    Beck, R.L.

    1995-01-01

    This article describes how, in one of the most successful steam-generator replacement experiences at PWRs worldwide, the V C Summer retrofit exceeded plant goals for critical-path duration, radiation, exposure, and radwaste generation. Intensive planning and teamwork, combined with the firm support of station management and the use of mockups to prepare the work crews for activity in a radiological environment, were key factors in the record performance achieved by South Carolina Electric and Gas Co (SCE and G) in replacing three steam generators at V C Summer nuclear station. The 97-day, two-hour breaker-to-breaker replacement outage -- including an eight-day delay for repair of leak in a small-bore seal-injection line of a reactor coolant pump (unrelated to the replacement activities) -- surpassed the project goal by over one day. Moreover, the outage was only 13 hours shy of the world record held by Virginia Power Co's North Anna Unit 1

  18. Nuclear facilities: repair and replacement technologies

    International Nuclear Information System (INIS)

    2005-01-01

    The oldest operating reactors are more than 35 years old and are now facing major maintenance operations. The first replacement of a pressurizer took place in autumn 2005 at the St-Lucie plant (Usa) while steam generators have been currently replaced since 1983. Nuclear industry has to adapt to this new market by proposing innovative technological solutions in the reactor maintenance field. This document gathers the 9 papers presented at the conference. The main improvements concern repair works on internal components of PWR-type reactors, the replacement of major components of the primary coolant circuit and surface treatments to limit the propagation of damages. The first paper shows that adequate design and feedback experience are good assets to manage the ageing of a nuclear unit. Another paper shows that a new repair method of a relief valve can avoid its replacement. (A.C.)

  19. Guide to optimized replacement of equipment seals

    International Nuclear Information System (INIS)

    Gleason, J.F.

    1990-03-01

    A reevaluation of current scheduled replacement intervals of polymeric seals in plant equipment can achieve significant benefits. Information is provided which has the potential for increasing replacement intervals based on better information on how seals have performed through unique nuclear industry tests to qualify equipment, improved elastomers and increased knowledge of the failure mechanisms and related performance. The research was performed by reviewing applications of elastomeric seals in nuclear plants and practice associated with defining seal replacement intervals in the nuclear power and other industries. Performance indicators and how they predict degradation of seals were evaluated. Guidelines and a flow chart for reevaluating seal replacement intervals are provided. 29 refs., 38 figs., 8 tabs

  20. Advances in bioanalytical techniques to measure steroid hormones in serum.

    Science.gov (United States)

    French, Deborah

    2016-06-01

    Steroid hormones are measured clinically to determine if a patient has a pathological process occurring in the adrenal gland, or other hormone responsive organs. They are very similar in structure making them analytically challenging to measure. Additionally, these hormones have vast concentration differences in human serum adding to the measurement complexity. GC-MS was the gold standard methodology used to measure steroid hormones clinically, followed by radioimmunoassay, but that was replaced by immunoassay due to ease of use. LC-MS/MS has now become a popular alternative owing to simplified sample preparation than for GC-MS and increased specificity and sensitivity over immunoassay. This review will discuss these methodologies and some new developments that could simplify and improve steroid hormone analysis in serum.

  1. Machine replacement, Network Externalities and Investment Cycles

    OpenAIRE

    Juan Ruiz

    2003-01-01

    This paper presents a model where agents decide on the timing of replacement of ageing machines. The optimal replacement policy for an agent is influenced by other agents' decisions because the productivity of a particular vintage displays network externalities that set in with a lag. In equilibrium, agents follow innovation cycles with a frequency that is lower than optimal, so there is too much delay. One extreme case is the possibility of inefficient collapse: for some parameters there is ...

  2. Equipment Replacement Decision Making: Opportunities and Challenges

    OpenAIRE

    Fan, Wei (David); Gemar, Mason D.; Machemehl, Randy

    2012-01-01

    The primary function of equipment managers is to replace the right equipment at the right time and at the lowest overall cost. In this paper, the opportunities and challenges associated with equipment replacement optimization (ERO) are discussed in detail. First, a comprehensive review of the state-of-the art and state-of-the practice literature for the ERO problem is conducted. Second, a dynamic programming (DP) based optimization solution methodology is presented to solve the ERO problem. T...

  3. Does Online Marketing Truly Replace Traditional Marketing?

    OpenAIRE

    Gunawan, Emilia Margareth

    2013-01-01

    This review explains the way how online marketing has been replacing traditional marketing in terms of marketing mix. This replacement might happen, because online marketing can give advantages, i.e., offering on-time delivery, increasing effectiveness of two way interactions between buyer and seller, and creating online communities (Szmigin, et al, 2005). The transition of atoms to bits format reflects that tangible products in traditional marketing is being digitalized. The marketing strate...

  4. Infective endocarditis following percutaneous pulmonary valve replacement

    DEFF Research Database (Denmark)

    Cheung, Gary; Vejlstrup, Niels; Ihlemann, Nikolaj

    2013-01-01

    Infective endocarditis (IE) following percutaneous pulmonary valve replacement (PPVR) with the Melody valve is rarely reported. Furthermore, there are challenges in this diagnosis; especially echocardiographic evidence of vegetation within the prosthesis may be difficult.......Infective endocarditis (IE) following percutaneous pulmonary valve replacement (PPVR) with the Melody valve is rarely reported. Furthermore, there are challenges in this diagnosis; especially echocardiographic evidence of vegetation within the prosthesis may be difficult....

  5. Effects of 18 months of L-T4 replacement in women with subclinical hypothyroidism.

    LENUS (Irish Health Repository)

    Adrees, M

    2012-02-01

    CONTEXT: Some of the cardiovascular and renal abnormalities seen in overt hypothyroidism have also been reported in subclinical hypothyroidism (SCH). Short-term L-T4 replacement in SCH improves cardiovascular risk markers and reduces carotid intima-media thickness (CIMT), a surrogate marker of atherosclerosis. The haemodynamic and renal effects of L-T4 replacement in SCH are poorly understood. OBJECTIVES: To compare cardiovascular risk factors and renal variables in women with SCH and normal women. To study the effects of L-T4 replacement in SCH subjects on these variables and on structural and functional changes in common carotid and brachial arteries. DESIGN: Fifty-six women with SCH before and after L-T4 replacement for 18 months and 56 normal women of similar age distribution were studied. Blood Pressure (BP), plasma lipids and homocysteine were measured and renal function evaluated [estimation of glomerular filtration rate (eGFR) using standard equations and measurement of serum Cystatin-C] in women with SCH before and after 18 months of l-T4, and in healthy women. CIMT and endothelial function (using brachial artery ultrasound) were studied before and after L-T4 in a subgroup of women with SCH. RESULTS: Systolic and diastolic BP, total cholesterol, triglyceride, LDL-cholesterol, lipoprotein(a) and homocysteine were greater in SCH (P < 0.05), and following L-T4 replacement decreased (P < 0.05) to levels that no longer differed from normal subjects. Estimated GFR was reduced and serum Cystatin-C increased (P < 0.05) in SCH. These variables also normalized following L-T4. Following L-T4 replacement the carotid artery baseline diameter increased by 7.1% and CIMT decreased by a mean value of 13%, while brachial artery diameter increased basally by 12.5% and following endothelium-dependent vasodilatation by 17.5% (P < 0.05). However, the increment following reactive hyperaemia did not differ before or following L-T4 replacement. CONCLUSION: Normalization of

  6. SrWO4 at high pressures

    International Nuclear Information System (INIS)

    Grzechnik, A.; Crichton, W.A.; Hanfland, M.

    2005-01-01

    Room-temperature high-pressure behaviour of SrWO 4 scheelite (I4 1 /a, Z=4) has been studied to 20.7 GPa in a diamond anvil cell using synchrotron angle-dispersive X-ray powder diffraction. Above 10 GPa, it transforms to the fergusonite structure (I2/a, Z=4). Both scheelite and fergusonite types are ordered superstructures of fluorite (Fm anti 3m, Z=4). There is no significant volume collapse at the scheelite-fergusonite phase transition. However, the compression data including both phases of strontium tungstate cannot be fitted by a common Birch-Murnaghan equation of state. An onset of decomposition into component oxides occurs at about 15 GPa. The pressure-induced transformations are irreversible. (copyright 2005 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  7. Chromatic bifocus alignment system for SR stepper

    International Nuclear Information System (INIS)

    Miyatake, Tsutomu

    1991-01-01

    A new alignment system developed for synchrotron radiation (SR) X-ray stepper is described. The alignment system has three key elements as follows. The first is a chromatic bifocus optics which observe high contrast bright images of alignment marks printed on a mask and a wafer. The second is broad band light illumination to observe the wafer alignment mark images which is unaffected by resist film coated on a wafer. The third is a new correlation function which is used in measuring of displacement between a mask and a wafer. The alignment system has achieved alignment accuracy on the order of 0.01 μm. The experimental results of this alignment system are discussed in this paper. (author)

  8. Dosimetry of Sr-90 ophthalmic applicators

    International Nuclear Information System (INIS)

    Reft, C.S.; Kuchnir, F.T.; Rosenberg, I.; Myrianthopoulos, L.C.

    1990-01-01

    Sr-90 ophthalmic applicators are commonly used for the treatment of superficial eye disorders. Although a variety of dosimetric devices such as film, thermoluminescent dosimeters (TLD's), ion chambers, and radiochromic foils have been used to measure the peak dose at the applicator surface, there is no internationally agreed upon calibration procedure. Recently, large discrepancies among calibrations of the same applicator at three institutions have been reported. Here we describe a technique to obtain the peak dose rate at the applicator surface using LiF TLD's. The technique can be used for the calibration of flat as well as curved surface applicators. Results for two flat and three concave applicators are presented. Our measurement of the surface dose rate for one of the flat applicators is compared with those obtained by four other institutions, each using different dosimetric devices

  9. Determination of 89Sr and 90Sr in highly radioactive water from a nuclear power plant

    International Nuclear Information System (INIS)

    Bojanowski, R.; Radecki, Z.; Duniec, S.

    1994-01-01

    The main criterion in assaying strontium radionuclides is to obtain radiochemically pure strontium sources for beta-particle counting. Nuclear power plant waters contain both 89 Sr and 90 Sr accompanied by many beta-particle and gamma-ray emitting fission and neutron-activation products. The latter activities can sometimes exceed those of strontium by a factor of 10 7 . Efficient purification procedures must be used to remove these products, preferably at an initial stage of analysis to reduce the radiation risk to personnel. A method has been developed in which a water sample is passed through a prefilter installed on top of an ion-exchange column filled with Dowex-50 resin in H + form. This prefilter is impregnated with ferrocyanides and manganese dioxide and retains most of the interfering radionuclides while the underlying cation-exchanger takes up strontium ions. A few additional purification steps result in a strontium salt that is free from other radioactivity. (orig.)

  10. Expert Opinion in SR 97 and the SKI/SSI Joint Review of SR 97

    Energy Technology Data Exchange (ETDEWEB)

    Hora, Stephen

    2002-09-01

    The role of sensitivity and uncertainty analyses for radioactive waste disposal assessments is reviewed. The report covers a description of the these concepts were applied in the authorities' review of the safety report SR 97. With regard to the use of expert knowledge, the most significant weakness of SR 97 is absence of any standards, procedures, and even definitions for expert judgment. This situation needs to be dealt with by SKB in the near future as it denigrates the portions of the study that are well done. In developing expert judgment processes, SSI should ensure that SKB creates procedures that guarantee traceability and transparency. This will become very important as the repository system matures and receives greater public scrutiny. Both in the area of scenario creation and expert judgement, there are processes that have gained international acceptance. It would be in the best interest of SKB, and the public, to adhere these accepted approaches.

  11. Expert Opinion in SR 97 and the SKI/SSI Joint Review of SR 97

    International Nuclear Information System (INIS)

    Hora, Stephen

    2002-09-01

    The role of sensitivity and uncertainty analyses for radioactive waste disposal assessments is reviewed. The report covers a description of the these concepts were applied in the authorities' review of the safety report SR 97. With regard to the use of expert knowledge, the most significant weakness of SR 97 is absence of any standards, procedures, and even definitions for expert judgment. This situation needs to be dealt with by SKB in the near future as it denigrates the portions of the study that are well done. In developing expert judgment processes, SSI should ensure that SKB creates procedures that guarantee traceability and transparency. This will become very important as the repository system matures and receives greater public scrutiny. Both in the area of scenario creation and expert judgement, there are processes that have gained international acceptance. It would be in the best interest of SKB, and the public, to adhere these accepted approaches

  12. 87Sr/86Sr ratios in hydrothermal waters and deposits from the east pacific rise at 210N

    International Nuclear Information System (INIS)

    Albarede, F.; Michard, A.; Minster, J.F.; Michard, G.

    1981-01-01

    87 Sr/ 86 Sr ratios of three hydrothermal waters collected on the East Pacific Rise at 21 0 N define a mixing line between seawater and a hydrothermal end-member at 0.7030 which is derived by seawater-basalt interaction at ca. 350 0 C and water/rock ratio of about 1.5. Sr concentrations are not affected in the process while Mg uptake from seawater is almost complete. Up to 2/3 of this hydrothermal component is involved in anhydrite precipitation while the Sr isotopic ratio in sulfides (chalcopyrite + sphalerite) cannot be distinguished from that of sulfate. It is estimated that ca. 1 x 10 10 moles of strontium are yearly cycled in the hydrothermal systems of mid-oceanic ridges, thereby affecting the 87 Sr/ 86 Sr budget of seawater. Mass balance between river runoff, limestone precipitation and ridge basalt alteration suggests that the 87 Sr/ 86 Sr ratios of the river runoff are in the range 0.7097-0.7113, and are largely dominated by limestone alteration. (orig.)

  13. In situ Sr/Sr investigation of igneous apatites and carbonates using laser-ablation MC-ICP-MS

    DEFF Research Database (Denmark)

    Bizzarro, Martin; Simonetti, A.; Stevenson, R.K.

    2003-01-01

    In situ Sr isotopic compositions of coexisting apatite and carbonate for carbonatites from the Sarfartoq alkaline complex, Greenland, have been determined by laser-ablation multicollector inductively coupled plasma mass spectrometry. This study is the first to examine the extent of Sr isotopic ho...

  14. 87Sr/86Sr isotopes in grapes of different cultivars: A geochemical tool for geographic traceability of agriculture products.

    Science.gov (United States)

    Tescione, Ines; Marchionni, Sara; Casalini, Martina; Vignozzi, Nadia; Mattei, Massimo; Conticelli, Sandro

    2018-08-30

    87 Sr/ 86 Sr was determined on fresh red and white grapes, soils and rocks from three selected vineyards to verify the isotopic relationships between the fruit of the vine and geologic substrata of vineyards. 87 Sr/ 86 Sr were determined on sampled grapes of four different harvest years and different grape varieties, on bioavailable fraction of soils, on whole soils, and on bedrocks from the geo-pedological substratum of the vineyards. The vineyards chosen for the experimental works belong to an organic farming winery and thus cultivation procedures were strictly controlled. Grapes were sampled during the harvests of four different but consecutive years with 87 Sr/ 86 Sr that does not change reflecting the values of the soil bioavailable fraction. No variations among grapes from different vine cultivars were observed. A strict isotope relationship with soil bio-available fraction was observed. These findings demonstrate the reliability of 87 Sr/ 86 Sr, even at a very small scale, for food products geographic origin assessment. Copyright © 2018 Elsevier Ltd. All rights reserved.

  15. Review of SKB's reporting of SR 97

    International Nuclear Information System (INIS)

    Tiren, S.A.

    2000-01-01

    The task of the safety assessment is to show 'that the repository has been designed with sufficient margins to be safe in spite of the incomplete knowledge available'. SKB mentions 'confidence in the results' as an important aspect. For the layman, confidence in the information presented is of the greatest importance. This means that the presentation of the safety assessment should be of a high visual standard with respect to descriptions of processes and events. SKB presented the purpose of SR 97 as four points. From a geological-structural geological viewpoint, the following can be mentioned: 1. Methodology for evaluating the geometry of the structural patterns of the bedrock at a depth of 500 m exists in general, but there are also certain deficiencies. Examples include determining the position of the individual structures and obtaining information. The importance of the bedrock is not completely clear. What is related to the rock type and what is related to the geological environment (including the geological evolution)? A clearer and more systematic compilation of data used in the safety assessment is required. 2. Work involving alternative models and evaluations of how well the models explain the collected data would be appropriate. The geological and structural models for a site are included as the base data in calculations and other modelling conducted in connection with the characterization of a site. 3. SR 97 does not provide any detailed information on site investigations. 4. The function of the bedrock as an external barrier is shown. However, to a certain extent, information on how this barrier can be affected by aseismic creep movements along fracture structures and the impact of selective erosion along such structures is lacking. Furthermore, criteria for properties of the rock volumes where deposition drifts are planned should be expanded, such as by determining a minimum width and suitable length-width relations

  16. Essential Specification Elements for Heat Exchanger Replacement

    Energy Technology Data Exchange (ETDEWEB)

    Bower, L.

    2015-07-01

    Performance upgrade and equipment degradation are the primary impetuses for a nuclear power plant to engage in the large capital cost project of heat exchanger replacement. Along with attention to these issues, consideration of heat exchanger Codes and Standards, material improvements, thermal redesign, and configuration are essential for developing User’s Design Specifications for successful replacement projects. The User’s Design Specification is the central document in procuring ASME heat exchangers. Properly stated objectives for the heat exchanger replacement are essential for obtaining the materials, configurations and thermal designs best suited for the nuclear power plant. Additionally, the code of construction required and the applied manufacturing standard (TEMA or HEI) affects how the heat exchanger may be designed or configured to meet the replacement goals. Knowledge of how Codes and Standards affect design and configuration details will aid in writing the User’s Design Specification. Joseph Oat Corporation has designed and fabricated many replacement heat exchangers for the nuclear power industry. These heat exchangers have been constructed per ASME Section III to various Code-Years or ASME Section VIII-1 to the current Code-Year also in accordance with TEMA and HEI. These heat exchangers have been a range of like-for-like replacement to complete thermal, material and configuration redesigns. Several examples of these heat exchangers with their Code, Standard and specification implications are presented. (Author.

  17. Strategic vehicle fleet management - the replacement problem

    Directory of Open Access Journals (Sweden)

    Adam Redmer

    2016-03-01

    Full Text Available Background: Fleets constitute the most important production means in transportation. Their appropriate management is crucial for all companies having transportation duties. The paper is the third one of a series of three papers that the author dedicates to the strategic vehicle fleet management topic. Material and methods: The paper discusses ways of building replacement strategies for companies' fleets of vehicles. It means deciding for how long to exploit particular vehicles in a fleet (the fleet replacement problem - FR. The essence of this problem lies in the minimization of vehicle / fleet exploitation costs by balancing ownership and utilization costs and taking into account budget limitations. In the paper an original mathematical model (an optimization method allowing for the FR analysis is proposed. Results: An application of the proposed optimization method in a real-life decision situation (the case study within the Polish environment and the obtained solution are presented. The solution shows that there exist optimal exploitation periods of particular vehicles in a fleet. However, combination of them gives a replacement plan for an entire fleet violating budget constraints. But it is possible to adjust individual age to replacement of particular vehicles to fulfill budget constraints without losing economical optimality of a developed replacement plan for an entire fleet. Conclusions: The paper is the last one of a series of three papers that the author dedicated to the strategic vehicle fleet management topic including the following managerial decision problems: MAKE-or-BUY, sizing / composition and replacement.

  18. International examples of steam generator replacement

    International Nuclear Information System (INIS)

    Wiechmann, K.

    1993-01-01

    Since 1979-1980 a total of twelve nuclear power plants world-wide have had their steam generators replaced. The replacement of the Combustion steam generators in the Millstone-2 plant in the United States was completed very recently. Steam generator replacement activities are going on at present in four plants. In North Anna, the steam generators have been under replacement since January 1990. In Japan, preparations have been started for Genkai-1. Since January 1992, the two projects in Beznau-1, Switzerland, and Doel-3, Belgium, have bee planned and executed in parallel. Why steam generator replacement? There are a number of defect mechanisms which give rise to the need for early steam generator replacement. One of the main reasons is the use of Inconel-600 as material for the heating tubes. Steam generator heating tubes made of Inconel-600 have been known to exhibit their first defects due to stress corrosion cracking after less than one year of operation. (orig.) [de

  19. A replaceable reflective film for solar concentrators

    Energy Technology Data Exchange (ETDEWEB)

    1991-09-01

    The 3M Company manufactures a silvered acrylic film called ECP-305 that is regarded as the preferred reflective film for use on stretched-membrane heliostats. However, ECP-305 will degrade in time, due to both corrosion of the silver layer and delamination at the film's silver-to-acrylic interface, and will eventually need to be replaced. 3M uses a very aggressive adhesive on this film, and once it is laminated, replacement is very difficult. The purpose of this investigation was the development of a replaceable reflector, a reflective film that can be easily removed and replaced. A replaceable reflector was successfully configured by laminating ECP-305 to the top surface of a smooth, dimensionally stable polymer film, with a removable adhesive applied to the underside of the polymer film. Several stages of screening and testing led to the selection of a 0.010-inch thick polycarbonate (GE 8030) as the best polymer film and a medium tack tape (3M Y-9425) was selected as the best removable adhesive. To demonstrate the feasibility of the replaceable reflector concept and to provide a real-time field test, the chosen construction was successfully applied to the 50-m{sup 2} SKI heliostat at the Central Receiver Test Facility at Sandia National Laboratories in Albuquerque. 4 refs., 13 figs., 7 tabs.

  20. Transgenerational isotopic marking of carp Cyprinus carpio, L. using a 86Sr /84Sr double spike

    Science.gov (United States)

    Zitek, Andreas; Cervicek, Magdalena; Irrgeher, Johanna; Horsky, Monika; Kletzl, Manfred; Weismann, Thomas; Prohaska, Thomas

    2013-04-01

    Transgenerational isotopic marking has been recognized recently as an effective tool for mass marking and tracking of individual fish to their original source. Compared to other conventional marking techniques, transgenerational marking offers several advantages. Most importantly, it is possible to mark all offspring of one individual female without the necessity of handling eggs or larval fish. Furthermore it is possible to vary the concentrations of individual isotopes to obtain specific marks for individual female fish. An enriched isotopic spike solution is usually applied to gravid female spawners by injection into the body cavity for transgenerational marking. The isotope is then incorporated into the central otolith region of the offspring which is known to be built up by maternally derived material. Within this study transgenerational marking of a typical cyprinid fish species, Cyprinus carpio, L., was tested using a 86Sr /84Sr double spike. Buffered solutions with different isotopic composition and concentrations were administered to 4 female individuals by intraperitoneal injection 5 days before spawning, while one female was injected a blank solution. After spawning, otoliths (Lapilli) from juvenile fish were sampled at the age of about 5 months at fish sizes between 3 and 4 cm and analyzed for their isotopic composition by LA-ICPMS applying cross sectional line scans. Central otolith regions of the progeny showed a shift in the natural isotope ratios for the administered isotopes. Deconvolution of the blank corrected measurement data of the Sr isotopes was done to trace back the original spike ratio. The different spike ratios could be well distinguished reflecting the original composition of the spike solution. This study proved that it is possible to create batch-specific unique transgenerational marks in otolith cores by varying the concentrations of two naturally occurring Sr isotopes. This method has high potential to reduce the marking effort for

  1. Fifteen years of GH replacement improves body composition and cardiovascular risk factors.

    Science.gov (United States)

    Elbornsson, Mariam; Götherström, Galina; Bosæus, Ingvar; Bengtsson, Bengt-Åke; Johannsson, Gudmundur; Svensson, Johan

    2013-05-01

    Few studies have determined the effects of more than 5-10 years of GH replacement in adults on body composition and cardiovascular risk factors. In this prospective, single-center, open-label study, the effects of 15 years of GH replacement on body composition and cardiovascular risk factors were determined in 156 hypopituitary adults (93 men) with adult-onset GH deficiency (GHD). Mean age was 50.5 (range 22-74) years at study start. Body composition was measured using dual-energy X-ray absorptiometry. The mean initial GH dose of 0.55 (S.E.M. 0.03) mg/day was gradually lowered to 0.40 (0.01) mg/day after 15 years. The mean serum IGF1 SDS increased from -1.53 (0.10) at baseline to 0.74 (0.13) at study end (Plevel at study end (Pbody fat (BF) started to increase and had returned to the baseline level after 15 years. Serum levels of total cholesterol and LDL-cholesterol decreased and serum HDL-cholesterol level increased. Fasting plasma glucose increased from 4.4 (0.1) at baseline to 4.8 (0.1) mmol/l at study end (P<0.001). However, blood HbA1c decreased from 5.0 (0.1) to 4.6 (0.1) % (P<0.001). Fifteen-year GH replacement in GHD adults induced a transient decrease in BF and sustained improvements of LST and serum lipid profile. Fasting plasma glucose increased whereas blood HbA1c was reduced.

  2. Applicability of 87Sr/86Sr in examining return flow of irrigation water in highly agricultural watersheds in Japan

    Science.gov (United States)

    Yoshida, T.; Nakano, T.; Shin, K. C.; Tsuchihara, T.; Miyazu, S.; Kubota, T.

    2017-12-01

    Water flows in watersheds containing extensive areas of irrigated paddies are complex because of the substantial volumes involved and the repeated cycles of water diversion from, and return to, streams. For better management of low-flow conditions, numerous studies have attempted to quantify the return flow using the stable isotopes of water; however, the temporal variation in these isotopic compositions due to fractionation during evaporation from water surfaces hinders their application to watersheds with extensive irrigated paddies. In this study, we tested the applicability of the strontium isotopes (87Sr/86Sr, hereafter Sr ratio) for studying hydrological processes in a typical agricultural watershed located on the alluvial fan of the Kinu River, namely the Gogyo River, in central Japan. The Sr ratio of water changes only because of interactions with the porous media it flows through, or because of mixing with water that has different Sr ratios. We sampled water both at a single rice paddy, and on the watershed scale in the irrigated and non-irrigated periods. The soil water under the paddy decreased as sampling depth increased, and the soil water at a depth of 1.5 m showed a similar Sr ratio to the spring. The water sampled in the drainage channel with a concrete lined bottom showed a similar Sr ratio to the irrigation water, whereas that with a soil bottom was plotted between the plots of the irrigation water and shallow aquifer. These results suggest the Sr ratio decreases as it mixes with the soil water through percolation; whereas the Sr ratio will be less likely to change when water drains from paddies via surface pathways. The streamflow samples were plotted linearly on the Sr ratio and 1/Sr plot, indicating that the streamflow was composed of two end-members; the irrigation water and the shallow aquifer. The continuous decline in the Sr ratio along the stream suggests an exfiltration of water from the shallow aquifers. The stream water during the non

  3. Existence of the uranyl ion at regular Sr site in U doped SrBPO5

    International Nuclear Information System (INIS)

    Mithlesh Kumar; Mohapatra, M.; Natarajan, V.

    2014-01-01

    Actinide doped alkaline earth borophosphates of the general formula MBPO 5 (M = Ca 2+ , Sr 2+ , Ba 2+ ) are of special interest due to array of defect centers that can be generated in these compounds by internal (α and γ) irradiation effects. Further, the crystalline alkaline earth borophosphates are also reported to be isostructural with stillwellite-LnBSiO 5 , which are built up by BO 4 and SiO 4 tetrahedra. This structure suggests that the host MBPO 5 should be a good matrix for luminescence investigations for suitable activator ions. The important advantages of MBPO 5 type systems are their high luminescence, moderate preparation temperature and low thermal degradation. XRD pattern of the prepared phosphor confirmed the formation of SrBPO 5 in a single phase. The presence of uranium in SrBPO 5 sample was ascertained from Energy Dispersive X-ray Fluorescence (EDXRF) measurements performed on a Jordan Valley instrument. The U content in the sample was found to be about 0.85%. An Inductively Coupled Plasma Atomic Emission Spectrometric (ICP-AES), Jobin Yvon, France was used for analysis of the sample, which showed all other metallic impurities except U to be present at concentrations below 5 :U, PL, TSL and ESR studies were conducted on the solid state route samples. PL and TSL techniques were used with a view to understand the species responsible for the luminescence and its site symmetry

  4. Interim FEP report for the safety assessment SR-Can

    Energy Technology Data Exchange (ETDEWEB)

    Skagius, Kristina (ed.) [Kemakta Konsult AB, Stockholm (Sweden)

    2004-08-01

    This report describes the work with identification and structuring of features, events and processes (FEPs) that has been carried out within the scope of the SR-Can safety assessment up to the time of the interim reporting of the project. The overall objective of the work is to develop a database of features, events and processes in a format that would facilitate both a systematic analysis of FEPs and documentation of the FEP analysis as well as facilitate revisions and updates to be made in connection with new safety assessments. This overall objective also includes the development of procedures for a systematic FEP analysis as well as to apply these procedures in order to arrive at an SR-Can version of the FEP database. The work started by implementing the content of the SR 97 Process report into a database format suitable for import and processing of FEP information from other sources. The SR 97 version of the database was systematically audited against the NEA database with Project FEPs, version 1.2. In addition, an earlier audit of the SR 97 process report against the interaction matrices developed for a deep repository of the KBS-3 type was revisited and updated. Relevant FEPs from the audit were sorted into three main categories in the SR-Can database i) FEPs related to the initial states of the repository system, ii) FEPs related to internal processes of the repository system, and iii) FEPs related to external impacts on the repository system. These groups of FEPs were further processed for making decisions on how to handle these FEPs in the assessment. Biosphere processes were not included in the SR 97 Process report and there is thus not the same basis for updating these descriptions as for the engineered barriers and the geosphere. All biosphere FEPs from the audit have therefore been compiled in a single category in the database, but remain to be further handled. FEPs were also categorised as irrelevant or as being related to methodology on a general

  5. Interim FEP report for the safety assessment SR-Can

    International Nuclear Information System (INIS)

    Skagius, Kristina

    2004-08-01

    This report describes the work with identification and structuring of features, events and processes (FEPs) that has been carried out within the scope of the SR-Can safety assessment up to the time of the interim reporting of the project. The overall objective of the work is to develop a database of features, events and processes in a format that would facilitate both a systematic analysis of FEPs and documentation of the FEP analysis as well as facilitate revisions and updates to be made in connection with new safety assessments. This overall objective also includes the development of procedures for a systematic FEP analysis as well as to apply these procedures in order to arrive at an SR-Can version of the FEP database. The work started by implementing the content of the SR 97 Process report into a database format suitable for import and processing of FEP information from other sources. The SR 97 version of the database was systematically audited against the NEA database with Project FEPs, version 1.2. In addition, an earlier audit of the SR 97 process report against the interaction matrices developed for a deep repository of the KBS-3 type was revisited and updated. Relevant FEPs from the audit were sorted into three main categories in the SR-Can database i) FEPs related to the initial states of the repository system, ii) FEPs related to internal processes of the repository system, and iii) FEPs related to external impacts on the repository system. These groups of FEPs were further processed for making decisions on how to handle these FEPs in the assessment. Biosphere processes were not included in the SR 97 Process report and there is thus not the same basis for updating these descriptions as for the engineered barriers and the geosphere. All biosphere FEPs from the audit have therefore been compiled in a single category in the database, but remain to be further handled. FEPs were also categorised as irrelevant or as being related to methodology on a general

  6. 90Sr- 90Y and 89Sr beta radioactivity measurement in milk samples using a proportional counter

    International Nuclear Information System (INIS)

    Mananes, A.; Perez Santos, C.; Martinez Churiaque, F.

    1987-01-01

    A thin window glas flow proportional counter is used to measure the 90 Sr- 90 Y and 89 Sr beta radioactivity in milk samples. A chemical procedure is used to separate strontium-yttrium from the other radionuclides present in milk. A calculation of the total efficiency of the system is performed which includes an empirical estimation of the backscattering factor. The calibration of the whole process allows the determination of the 90 Sr activity within 10% relative error in spite of uncertainties in the recovery yields of strontium and yttrium. No 89 Sr activity has been detected, and the mean value obtained for the 90 Sr activity in nine milk samples of Cantabria is 0.115 Bq/1 with a minimum detectable activity of 0.0105 Bq. (author) 18 refs

  7. Calcilytic Ameliorates Abnormalities of Mutant Calcium-Sensing Receptor (CaSR) Knock-In Mice Mimicking Autosomal Dominant Hypocalcemia (ADH).

    Science.gov (United States)

    Dong, Bingzi; Endo, Itsuro; Ohnishi, Yukiyo; Kondo, Takeshi; Hasegawa, Tomoka; Amizuka, Norio; Kiyonari, Hiroshi; Shioi, Go; Abe, Masahiro; Fukumoto, Seiji; Matsumoto, Toshio

    2015-11-01

    Activating mutations of calcium-sensing receptor (CaSR) cause autosomal dominant hypocalcemia (ADH). ADH patients develop hypocalcemia, hyperphosphatemia, and hypercalciuria, similar to the clinical features of hypoparathyroidism. The current treatment of ADH is similar to the other forms of hypoparathyroidism, using active vitamin D3 or parathyroid hormone (PTH). However, these treatments aggravate hypercalciuria and renal calcification. Thus, new therapeutic strategies for ADH are needed. Calcilytics are allosteric antagonists of CaSR, and may be effective for the treatment of ADH caused by activating mutations of CaSR. In order to examine the effect of calcilytic JTT-305/MK-5442 on CaSR harboring activating mutations in the extracellular and transmembrane domains in vitro, we first transfected a mutated CaSR gene into HEK cells. JTT-305/MK-5442 suppressed the hypersensitivity to extracellular Ca(2+) of HEK cells transfected with the CaSR gene with activating mutations in the extracellular and transmembrane domains. We then selected two activating mutations locating in the extracellular (C129S) and transmembrane (A843E) domains, and generated two strains of CaSR knock-in mice to build an ADH mouse model. Both mutant mice mimicked almost all the clinical features of human ADH. JTT-305/MK-5442 treatment in vivo increased urinary cAMP excretion, improved serum and urinary calcium and phosphate levels by stimulating endogenous PTH secretion, and prevented renal calcification. In contrast, PTH(1-34) treatment normalized serum calcium and phosphate but could not reduce hypercalciuria or renal calcification. CaSR knock-in mice exhibited low bone turnover due to the deficiency of PTH, and JTT-305/MK-5442 as well as PTH(1-34) increased bone turnover and bone mineral density (BMD) in these mice. These results demonstrate that calcilytics can reverse almost all the phenotypes of ADH including hypercalciuria and renal calcification, and suggest that calcilytics can become a

  8. Human autologous serum as a substitute for fetal bovine serum in human Schwann cell culture.

    Directory of Open Access Journals (Sweden)

    Parisa Goodarzi

    2014-04-01

    Full Text Available Nowadays, cell -based and tissue engineered products have opened new horizons in treatment of incurable nervous system disorders. The number of studies on the role of Schwann cells (SC in treating nervous disorders is higher than other cell types. Different protocols have been suggested for isolation and expansion of SC which most of them have used multiple growth factors, mitogens and fetal bovine sera (FBS in culture medium. Because of potential hazards of animal-derived reagents, this study was designed to evaluate the effect of replacing FBS with human autologous serum (HAS on SC's yield and culture parameters. Samples from 10 peripheral nerve biopsies were retrieved and processed under aseptic condition. The isolated cells cultured in FBS (1st group or autologous serum (2nd group. After primary culture the cells were seeded at 10000 cell/cm2 in a 12 wells cell culture plate for each group. At 100% confluency, the cell culture parameters (count, viability, purity and culture duration of 2 groups were compared using paired t-test. The average donors' age was 35.80 (SD=13.35 and except for 1 sample the others cultured successfully. In first group, the averages of cell purity, viability and culture duration were 97% (SD=1.32, 97/33% (SD=1.22 and 11.77 (SD=2.58 days respectively. This parameters were 97.33% (SD=1.00, 97.55% (SD=1.33 and 10.33 days (SD=1.65 in second group. The difference of cell count, purity and viability were not significant between 2 groups (P>0.05. The cells of second group reached to 100% confluency in shorter period of time (P=0.03. The results of this study showed that autologous serum can be a good substitute for FBS in human SC culture. This can reduce the costs and improve the safety of cell product for clinical application.

  9. Control of treatment of differentiated thyroid carcinoma by measurement of thyroglobulin in serum

    International Nuclear Information System (INIS)

    Hagemann, J.; Schneider, C.

    1978-01-01

    The presence of thyroglobulin in serum of patients with differentiated thyroid carcinoma was studied by a specific radioimmunoassay. Seventy-three patients with thyroid carcinomata were examined, 16 of whom had pulmonary or skeletal metastase, 11 local metastases, and the others no metastases. Patients with generalized metastases had very high serum thyroglobulin concentrations while those with local metastases had slightly elevated or normal concentrations. Those with remaining thyroid tissue had mainly normal thyroglobulin levels and patients with neither metastases nor remaining thyroid tissue had undetectable serum thyroglobulin. In seven patients with metastases it was possible to observe the development of serum thyroglobulin after 131 I treatment. In all cases the serum thyroglobulin concentration paralleled the development of the clinical status. Elevated serum thyroglobulin was also found in benign thyroid diseases such as hyperthyroidism and endemic goitre. Measurement of thyroglobulin in serum is therefore of little value in differentiating between benign and malignant thyroid diseases, but it is a good method for the follow-up control of patients with differentiated thyroid carcinomata. Because normal thyroglobulin levels do not exclude local metastases, additional examinations are necessary if normal thyroglobulin levels are found. When thyroglobulin is undetectable, metastases can be excluded and the measurement of thyroglobulin in serum can replace all other methods in the follow-up control. (author)

  10. Changes in local surface structure and Sr depletion in Fe-implanted SrTiO{sub 3} (001)

    Energy Technology Data Exchange (ETDEWEB)

    Lobacheva, O., E-mail: olobache@gmail.com [Department of Physics and Astronomy, Western University, London, ON N6A 5B7 (Canada); Yiu, Y.M. [Department of Chemistry, Western University, London, ON N6A 5B7 (Canada); Chen, N. [Canadian Light Source, Saskatoon, SK S7N 0X4 (Canada); Sham, T.K.; Goncharova, L.V. [Department of Physics and Astronomy, Western University, London, ON N6A 5B7 (Canada); Department of Chemistry, Western University, London, ON N6A 5B7 (Canada)

    2017-01-30

    Highlights: • Fe ion implantation of SrTiO{sub 3} and post-implantation results in formation of Sr{sub 1-y}Ti{sub 1-x}Fe{sub x+y}O{sub 3-δ} phase. • In Sr{sub 1-y}Ti{sub 1-x}Fe{sub x+y}O{sub 3-δ} phase, Fe assumes Fe{sup 3+} oxidation state in the bulk and Fe{sup 2+} oxidation state in the near surface area. • FEFF9 calculations indicate that Fe ions can substitute both Ti and Sr sites. • Formation of Sr{sub 1-y}Ti{sub 1-x}Fe{sub x+y}O{sub 3-δ} phase is accompanied by Sr depletion in the near surface region. - Abstract: Local surface structure of single crystal strontium titanate SrTiO{sub 3} (001) samples implanted with Fe in the range of concentrations between 2 × 10{sup 14} to 2 × 10{sup 16} Fe/cm{sup 2} at 30 keV has been investigated. In order to facilitate Fe substitution (doping), implanted samples were annealed in oxygen at 350 °C. Sr depletion was observed from the near-surface layers impacted by the ion-implantation process, as revealed by Rutherford Backscattering Spectrometry (RBS), X-ray photoelectron spectroscopy (XPS), X-ray Absorption Near Edge Spectroscopy (XANES), and Atomic Force Microscopy (AFM). Hydrocarbon contaminations on the surface may contribute to the mechanisms of Sr depletion, which have important implications for Sr(Ti{sub 1-x}Fe{sub x})O{sub 3-δ} materials in gas sensing applications.

  11. Serum N-terminal-pro-brain natriuretic peptide level and its clinical implications in patients with atrial fibrillation.

    Science.gov (United States)

    Bai, Mei; Yang, Jiefu; Li, Yingying

    2009-12-01

    Brain natriuretic peptide (BNP) is increasingly being used for screening and monitoring of congestive heart failure. However, the role of BNP in patients with atrial fibrillation (AF) and normal left ventricular function has not been determined. This study investigates serum N-terminal pro-brain natriuretic peptide (NT-proBNP) level and its clinical implications in patients with AF. Serum NT-proBNP levels were measured by enzyme-linked immunosorbent assay (ELISA) and transthoracic echocardiography was performed in 136 subjects (90 cases with AF and 46 cases with sinus rhythm [SR]). Subjects were excluded if they had a history of myocardial infarction, cardiomyopathy, rheumatic heart disease, or hyperthyroidism that preceded the onset of AF. Controls (n = 30) were from a healthy outpatient primary care population. Potential determinants of serum NT-proBNP levels were identified by univariate and multivariate analyses. Individuals with AF had higher serum NT-proBNP levels (689.56 +/- 251.87 fmol/ml) than those with SR (456.11 +/- 148.14 fmol/ml, P NT-proBNP levels (P > 0.05). The regression model of serum NT-proBNP levels and clinical predictors showed that presence of AF, older age, and larger right atrial diameter were independently predictive of higher serum NT-proBNP values. Patients with AF were associated with increased serum NT-proBNP levels. Examining the change of serum NT-proBNP levels is helpful to evaluate the cardiac function in patients with AF. Copyright 2009 Wiley Periodicals, Inc.

  12. Deposition of 90Sr in bone and the relevant dose

    International Nuclear Information System (INIS)

    Kawamura, Hisao

    1976-01-01

    The deposition of fallout 90 Sr in bone and radiation dose from the nuclide in Japan is reviewed with special reference to (i) the intraskeletal distribution of 90 Sr and reference bone, (ii) bone models for predicting 90 Sr level and (iii) possible problems in applying dose rate factors to Japanese, especially to infants and adolescents. An evidence is presented for the assumption that the ratio of the 90 Sr concentration in a particular bone to that in vertebra will reach the ratio observed for stable strontium under the virtually constant intake of 90 Sr. The importance of surveying 90 Sr levels in different bones is stressed. Observed Ratios (bone/diet) found for Japanese are noticeably lower than those reported for Europeans and Americans. The recently presented model for the retention of alkaline earth elements in man by ICRP will be useful if only adults are concerned. Dose rate factors for 90 Sr in bone should be given as a function of age for the purpose of better estimation of dose commitments. The cumulative absorbed doses to bone tissues calculated with the Palmley-Mays model and with the Spiers model show remarkably higher levels in school children and young adults than the mean level. (auth.)

  13. Sr and Nd isotope systematics in fish teeth

    International Nuclear Information System (INIS)

    Staudigel, H.; Zindler, A.

    1985-01-01

    High concentrations of Sr and Nd in fish teeth apatite (up to 2000 and 3800 ppm, respectively) make them relatively impervious to diagenetic overprints and allow high-precision analysis of 87 Sr/ 86 Sr and 143 Nd/ 144 Nd of very small amounts of material. 87 Sr/ 86 Sr ratios of 14 Cenozoic samples ( 87 Sr/ 86 Sr stratigraphic dating. A compilation of published 143 Nd/ 144 Nd data from recent Mn-nodules and marine Fe/Mn deposits shows that the North-Central Pacific Ocean and the major portion of the Atlantic Ocean display distinctly different, narrow ranges in isotopic compositions. Between these two areas, the 143 Nd/ 144 Nd of Mn-nodules vary systematically towards intermediate compositions in the Southern Oceans, reflecting the communication between the Atlantic and Pacific Oceans through the eastward moving Antarctic Circumpolar Current. The 143 Nd/ 144 Nd of the 2-55 Ma old fish teeth analyzed are typically close to the range of 143 Nd/ 144 Nd in Recent Mn-nodules and seawater for the respective ocean and, thus, indicate no significant change through this time period. The 143 Nd/ 144 Nd of fish teeth from the North Pacific Ocean are highest during periods of high aeolian sedimentation. (orig.)

  14. Determination of 90Sr by liquid scintillation counting

    International Nuclear Information System (INIS)

    Cerchetti, Maria L.; Aghazarian, V.P.

    2006-01-01

    99m Tc, the result of the radioactive decay of 99 Mo, is one of the most applied radioisotopes in nuclear medicine and is used in nuclear medicine as a radiopharmaceutical product. It is important to ensure 99 Mo quality in order to fit the 99m Tc quality specifications. The main objective was to obtain a technique for 90 Sr determination in 99 Mo and environmental samples. The purification of 90 Sr is performed by extraction chromatography where crown-ether resin (Sr-Spec, Eichrom) was used. The measurement of the 90 Sr activity is performed by Liquid Scintillation Counting (LSC) using the double windows method. This method permits the 90 Sr determination without waiting until radiochemical equilibrium 90 Sr / 90 Y has been reached. The recovery factor was determined by gamma spectrometry with 85 Sr, and by gravimetry with stable strontium carrier solution. The minimum detectable activity was 0,05 Bq. The recovery factor was the major contribution in the total uncertainty. (author)

  15. PRODUCTION OF PLANTARCIN BY LACTOBACILLUS PLANTARUM SR18

    Directory of Open Access Journals (Sweden)

    Wagih El-Shouny

    2012-06-01

    Full Text Available Out of 86 lactobacilli previously screened in our laboratory, Lactobacillus plantarum SR18 isolated from yoghurt revealed the largest detected inhibition zone against the selected indicator Streptococcus salivarius 5. The obtained electrophoretic patterns revealed that L. plantarum SR18 was free from plasmids. Exposure of 6 h growing L. plantarum culture to T-8M, 3B ultraviolet B lamp (8w, 220v & 312 nm for 2 h and subsequent growth for further 24 h resulted in an increase of cell-bound bacteriocin titer reached 2 fold at 12 h. Whereas bacteriocin secreted in the culture filtrate was not affected by UV irradiation. Plantarcin SR18 production was maximal (12800 AU/ml between 12 and 18 h by incubation of the culture at 37°C and pH 5-7 in candle jar (CO2. The bacteriocin bound to the cells and that secreted into the culture filtrate of L. plantarum SR18 were precipitated by 75% ammomium sulphate, dialysed and further purified by Gel filtration on Sephadex G-100. The specific activities (AU/mg protein were increased by a factor of about 5.3 and 2.35 for plantarcins purified from proteins bound to the cell of L. plantarum SR18 (plantarcin SR18 a and that secreted into the culture filtrate (plantarcin SR18 b, respectively. Gel filtration of plantarcin SR18a resulted in moderate antibacterial activity (3200 AU/ml and very high activity (25600 AU/ml of plantarcin SR18b.

  16. Glycaemic, uricaemic and blood pressure response to beverages with partial fructose replacement of sucrose.

    Science.gov (United States)

    Rodrigues, Natasha; Peng, Mei; Oey, Indrawati; Venn, Bernard Joseph

    2018-03-20

    The European Food Safety Authority approved a health claim (ID558) relating to lowered postprandial glycaemia when fructose replaces 30% of sucrose in foods and beverages. We assessed the effects of partial replacement of sucrose with fructose on serum glucose, uric acid and blood pressure. A randomised, crossover, double blind trial of 12 normoglycaemic participants consuming beverages containing 50 g blends of fructose and sucrose in proportions; 67% sucrose/33% fructose (67%S:33%F); 50% each (50%S:50%F) and 33%S:67%F; a 100% sucrose reference beverage was tested twice. Serum glucose and uric acid concentrations were measured at 0, 15, 30, 45, 60, 90 and 120 min and incremental area-under-the-curve (iAUC) calculated. The geometric mean (95% CI) glycaemic iAUC following the 100% sucrose, 67%S:33%F, 50%S:50%F and 33%S:67%F blended beverages were 96 (63,145), 71 (46,109), 60 (39, 93) and 39 (12, 86) mmol/L min, respectively. At 33% fructose replacement, the proportionally lower iAUC of -28.5% (95% CI: -62.1, 5.2) mmol/L min was not different to sucrose alone. The response was lowered by fructose replacement of 50 and 67% and overall there was an inverse association (p beverages were 1320 (393, 2248), 3062 (1553, 4570), 3646 (2446, 4847), 3623 (2020, 5226) µmol/L min. Uric acid concentration was raised by all fructose-containing beverages with 33% fructose replacement causing an increase of 1741 (95% CI: 655, 2829) µmol/L min compared with sucrose alone. Blood pressure was not different among beverages. Reduced postprandial glycaemia was achieved by the substitution of sucrose with fructose although elevated uricaemic responses should be cautioned.

  17. Effects of amount of colostrum replacer, amount of milk replacer, and housing cleanliness on health, growth, and intake of Holstein calves to 8 weeks of age.

    Science.gov (United States)

    Quigley, J D; Hill, T M; Deikun, L L; Schlotterbeck, R L

    2017-11-01

    Newborn Holstein bull calves (n = 96) were assigned randomly at birth to receive 150 g (C150) or 450 g (C450) of IgG in the first 24 h of life from a lacteal-based colostrum replacer in 2 trials. Mass of product fed was 500 and 1,500 g, respectively. Replacer was reconstituted with warm water and administered by esophageal feeder at approximately 1, 6, and 12 h of age. Thereafter, calves were fed 2 L of whole milk twice daily at approximately 0700 and 1700 h until transported to the experimental facility at 2 to 3 d of age. Calves fed C450 had greater serum total protein and IgG concentrations at 2 to 3 d of age. Failure of passive transfer of immunity (serum IgG calves fed C150 and C450, respectively. Calves (n = 48) in trial 1 were assigned randomly within colostrum group to receive 0.68 kg/d of milk replacer (MR) for 42 d, and then 0.34 kg/d for 7 d (moderate MR, MMR) or 1 kg/d of MR for 5 d, 1.36 kg/d for 37 d, and 0.68 kg/d for 7 d (high MR, HMR). Starter and water were available for ad libitum consumption. Calves fed HMR had greater average daily gain, higher average fecal scores, more days with abnormal fecal scores, and more medical days than calves fed MMR. Calves fed HMR also had lower starter intake and tended to have lower gain-to-feed ratio than calves fed MMR. Calves fed C450 and MMR began eating calf starter earlier and ate more starter than other groups from 3 wk. In trial 2, calves (n = 48) were assigned randomly within colostrum group to housing in nursery pens bedded with clean, dry straw (clean bedding) or soiled straw used in previous studies (dirty bedding). Milk replacer was fed at 0.68 kg/d for 39 d, and then 0.34 kg/d for 3 d along with free-choice texturized starter and water. Calves fed C450 had fewer days with abnormal fecal scores and days with medical treatments compared with calves fed C150. Calves housed in dirty bedding tended to grow more slowly and have lower gain-to-feed ratio than calves housed with clean bedding. Temporal

  18. Structural considerations in steam generator replacement

    International Nuclear Information System (INIS)

    Bertheau, S.R.; Gazda, P.A.

    1991-01-01

    Corrosion of the tubes and tube-support structures inside pressurized water reactor (PWR) steam generators has led many utilities to consider a replacement of the generators. Such a project is a major undertaking for a utility and must be well planned to ensure an efficient and cost-effective effort. This paper discusses various structural aspects of replacement options, such as total or partial generator replacement, along with their associated pipe cuts; major structural aspects associated with removal paths through the equipment hatch or through an opening in the containment wall, along with the related removal processes; onsite movement and storage of the generators; and the advantages and disadvantages of the removal alternatives. This paper addresses the major structural considerations associated with a steam generator replacement project. Other important considerations (e.g., licensing, radiological concerns, electrical requirements, facilities for management and onsite administrative activities, storage and fabrication activities, and offsite transportation) are not discussed in this paper, but should be carefully considered when undertaking a replacement project

  19. Nuclear safety activities in the SR of Slovenia in 1986

    International Nuclear Information System (INIS)

    Susnik, J.

    1987-06-01

    Currently Yugoslavia has one 632 MWe nuclear power plant (NPP) of PWR design, located at Krsko in the Socialist Republic (SR) of Slovenia. Krsko NPP, which is a two-loop plant, started power operation in 1981. In general, reactor safety activities in the SR of Slovenia are mostly related to upgrading the safety of our Krsko NPP and to developing capabilities for use in future units. This report presents the nuclear safety related legislation and organization of the corresponding regulatory body, and the activities related to nuclear safety of the participating organizations in the SR of Slovenia in 1986. (author)

  20. Optical properties of SrTiO3 films

    International Nuclear Information System (INIS)

    Agasiyev, A.A.; Magerramov, E.M.; Mammadov, M.Z.; Sarmasov, S.M.

    2010-01-01

    The spectrums of optical absorption of amorphous and single crystalline films SrTiO 3 at temperatures : 105 K, 300 K, 400 K are investigated. The temperature dependences of slope absorption edge, forbidden gap and characteristic constant of Urbah rule are obtained. The forbidden gap of single crystalline film SrTiO 3 and average shift shift of absorption edge degree are defined. It is established that edge of optical absorption of SrTiO 3 film is obeyed to Urbah rule and the absorption in the investigated region is caused by the transition of electron interacting with phonon

  1. Nuclear safety activities in the SR of Slovenia in 1986

    Energy Technology Data Exchange (ETDEWEB)

    Susnik, J [Inst. Jozef Stefan, Ljubljana (Slovenia)

    1987-06-15

    Currently Yugoslavia has one 632 MWe nuclear power plant (NPP) of PWR design, located at Krsko in the Socialist Republic (SR) of Slovenia. Krsko NPP, which is a two-loop plant, started power operation in 1981. In general, reactor safety activities in the SR of Slovenia are mostly related to upgrading the safety of our Krsko NPP and to developing capabilities for use in future units. This report presents the nuclear safety related legislation and organization of the corresponding regulatory body, and the activities related to nuclear safety of the participating organizations in the SR of Slovenia in 1986. (author)

  2. AB19. Testosterone replacement therapy: how safe is it?

    Science.gov (United States)

    Goldenberg, Larry

    2014-01-01

    controversies surrounding testosterone replacement therapy (TRT) have been addressed in the past few years. Although the androgenic effects of TRT on normal and malignant prostate cells have been studied for over 70 years, little clinical prospective research exists on the physiological responses of prostate tissues to a wide range of serum testosterone levels. The early, well-designed in vivo studies formed the basis of the concept that testosterone has a threshold or saturation level in all types of androgen-dependent prostate cells. That is, the stimulatory effects of androgens on the prostate reach a point within physiological serum levels above which they no longer have any proliferative effect and serum levels of testosterone and dihydrotestosterone can decrease substantially in both the eugonadal and hypogonadal states without affecting the amount of androgen within the nucleus of the cell. At a certain threshold level (possibly ‘castrate’ level), the intranuclear level of androgen will begin to decrease and the appropriate physiological changes will be triggered. Questions remain as to whether results from experimental studies in the rat can be extrapolated to the situation in humans. Is the human prostate subject to the same homeostatic constraints as has been so well defined in animal experiments, and if so, what is the threshold or saturation level for maximal intracellular androgens and physiological responses in man? The sensitivity of an individual to varying levels of testosterone is also influenced by his genetic makeup, particularly polymorphisms in the androgen receptor, and other upstream signaling and downstream metabolic events, including diabetes mellitus and obesity. Despite decades of research, no compelling evidence exists that increasing testosterone beyond this threshold level has a causative role in prostate cancer, or indeed changes the biology of the disease. Notwithstanding this, the reluctance to utilize testosterone replacement has been

  3. Hip or knee replacement - in the hospital after

    Science.gov (United States)

    Hip replacement surgery - after - self-care; Knee replacement surgery - after - self-care ... taking walks in the hallways with help. After knee replacement, some surgeons recommend using a continuous passive ...

  4. Study of photo-stimulated luminescence in Ba0.95M0.05FBr:Eu2+ (M = Sr, Ca) powder

    International Nuclear Information System (INIS)

    Zhou Yingxue; Wang Dongsheng; Zhang Xinyi

    2001-01-01

    The luminescence centered at about 390 nm due to 4f 6 5d→4f 7 transition of Eu 2+ can be observed without X-ray or UV-light pre-irradiation for BaFBr:Eu 2+ , Ba 0.95 Sr 0.05 FBr:Eu 2+ and Ba 0.95 Ca 0.05 FBr:Eu 2+ powder samples which can be excited by light with wave length longer than 400 nm. It could be attributed to F centers which are formed in the preparation of samples. There are two broad bands in the photo-stimulated spectra. One peaked at 535 nm results from the excitation of electrons at F(F - ) center, and the other at 708 nm might be originated from the electron excitation of F(Br - ) center or F(Br - ) accumulators. If the Ba 2+ (ion's radius equals to 0.135 nm) in the samples were replaced by about 50% mol. of Sr 2+ (ion's radius equals to 0.113 nm) or Ca 2+ (ion's radius equals to 0.099 nm), the intensities of 535 nm and 708 nm bands decrease with the decreasing of ion radius. On the other hand, the shoulders at 580 nm and 650 nm or 575 nm and 645 nm can appear. In absorption spectra of 50-400 nm range, one can observe the red-shift of 79 nm, 83 nm peaks and new absorption peaks. It means that the new color centers: F(F - , Sr 2+ ), F(br - , Sr 2+ ) or F(F - , Ca 2+ ), F(br - , Ca 2+ ) are formed, when Ba 2+ were replaced with Sr 2+ or Ca 2+ in samples. It corresponds to the shoulders in photo-stimulated spectra

  5. Magnetic transitions in double perovskite Sr2FeRe1-xSbxO6 (0≤x≤0.9)

    International Nuclear Information System (INIS)

    Jung, Alexandra; Ksenofontov, Vadim; Reiman, Sergey; Therese, Helen Annal; Felser, Claudia; Tremel, Wolfgang; Kolb, Ute

    2006-01-01

    The double perovskites Sr 2 FeMO 6 (M=Re,Mo) belong to the important class of half-metallic magnetic materials. In this study we explore the effect of replacing the electronic 5d buffer element Re with variable valency by the main group element Sb with fixed valency. X-ray diffraction reveals Sr 2 FeRe 1-x Sb x O 6 (0 2 FeReO 6 changes to antiferromagnetic upon Sb substitution as was determined by magnetic susceptibility measurements. Samples up to a doping level of 0.3 are ferrimagnetic, while Sb contents higher than 0.6 result in an overall antiferromagnetic behavior. 57 Fe and 121 Sb Moessbauer spectroscopy specifies the valence state of Sb to be +5 within the whole range of substitution whereas the Fe valence state changes from +2.7 for the parent compound to +2.9 for Sr 2 FeRe 0.1 Sb 0.9 O 6 . Accordingly, Fe adopts the role of an electronic buffer element from Re upon heavy Sb doping. Additionally, 57 Fe Moessbauer results show a coexistence of ferri- and antiferromagnetic clusters within the same perovskite-type crystal structure in the Sb substitution range 0.3 2 FeReO 6 and Sr 2 FeRe 0.9 Sb 0.1 O 6 are ''purely'' ferrimagnetic and Sr 2 FeRe 0.1 Sb 0.9 O 6 contains antiferromagnetically ordered Fe sites only. Consequently, a replacement of the Re atoms by a nonmagnetic main group element such as Sb blocks the superexchange pathways -Fe-O-Re(Sb)-O-Fe- along the crystallographic axis of the perovskite unit cell and destroys the itinerant magnetism of the parent compound

  6. Study on the serum prolactin (PRL) level in post-menopausal women

    International Nuclear Information System (INIS)

    Li Wenqi; Li Xin; Zhou Jiwen; Zhou Zhengli

    2004-01-01

    Objective: To explore the clinical value of determination of serum PRL levels inpost-menopausal women. Methods: Serum PRL levels were determined with RIA in 596 post-menopausal women (age 45-59, mean 55). Results: The normal range of serum PRL level in this laboratory was 0-30 ng/ml. Among the 596 women tested, 77(13%) had their PRL levels above 30 ng/ml. Further investigation with CT and/or MRI revealed presence of micro-pituitary-adenoma in 31 of the Symptoms of menopausal syndrome and osteoporosis were much more severe in women with hyperprolactinemia then in those without. Conclusion: As hyperprolactinemia might be a high risk factor for development of breast cancer, hormone replacement therapy (HRT) in menopausal women with hyperprolactinemia should be applied very cautiously, even withheld at all. Determination of serum prolactin levels in post-menopausal women is of practical clinical value. (authors)

  7. Humant serum-albumin som proteinkilde ved dyrkning af humane oocytter, spermatozoer og praeembryoer

    DEFF Research Database (Denmark)

    Andersen, C Y; Hay-Schmidt, Anders; Byskov, A G

    1991-01-01

    patient serum as source of protein in the culture of oocytes, spermatozoa and pre-embryos in IVF-ET treatment. The pregnancy rate per transplantation was increased from 30% in the serum group (21 pregnant out of 69 transplantations) to 39% in the albumin group (26 pregnant out of 66 transplantations...... takes place, also consists of a source of protein. In order to eliminate the variability of patient sera, a prospective, randomized investigation was performed to elucidate whether a well-defined source of protein such as human serum albumin (hSA-hSA 200 mg/ml, Statens Seruminstitute) can replace......SA is recommended as the source of protein, rather than the patient's own serum in the culture of oocytes, spermatozoa and pre-embryos in IVF-ET treatment....

  8. Surface modeling and chemical solution deposition of SrO(SrTiO3)n Ruddlesden-Popper phases

    International Nuclear Information System (INIS)

    Zschornak, M.; Gemming, S.; Gutmann, E.; Weissbach, T.; Stoecker, H.; Leisegang, T.; Riedl, T.; Traenkner, M.; Gemming, T.; Meyer, D.C.

    2010-01-01

    Strontium titanate (STO) is a preferred substrate material for functional oxide growth, whose surface properties can be adjusted through the presence of Ruddlesden-Popper (RP) phases. Here, density functional theory (DFT) is used to model the (1 0 0) and (0 0 1) surfaces of SrO(SrTiO 3 ) n RP phases. Relaxed surface structures, electronic properties and stability relations have been determined. In contrast to pure STO, the near-surface SrO-OSr stacking fault can be employed to control surface roughness by adjusting SrO and TiO 2 surface rumpling, to stabilize SrO termination in an SrO-rich surrounding or to increase the band gap in the case of TiO 2 termination. RP thin films have been epitaxially grown on (0 0 1) STO substrates by chemical solution deposition. In agreement with DFT results, the fraction of particular RP phases n = 1-3 changes with varying heating rate and molar ratio Sr:Ti. This is discussed in terms of bulk formation energy.

  9. Magnetism in the p-type Monolayer II-VI semiconductors SrS and SrSe

    Science.gov (United States)

    Lin, Heng-Fu; Lau, Woon-Ming; Zhao, Jijun

    2017-01-01

    Using density functional theory calculations, we study the electronic and magnetic properties of the p-type monolayer II-VI semiconductors SrX (X = S,Se). The pristine SrS and SrSe monolayers are large band gap semiconductor with a very flat band in the top valence band. Upon injecting hole uniformly, ferromagnetism emerges in those system in a large range of hole density. By varying hole density, the systems also show complicated phases transition among nonmagnetic semiconductor, half metal, magnetic semiconductor, and nonmagnetic metal. Furthermore, after introducing p-type dopants in SrS and SrSe via substitutionary inserting P (or As) dopants at the S (or Se) sites, local magnetic moments are formed around the substitutional sites. The local magnetic moments are stable with the ferromagnetic order with appreciable Curie temperature. The ferromagnetism originates from the instability of the electronic states in SrS and SrSe with the large density of states at the valence band edge, which demonstrates a useful strategy for realizing the ferromagnetism in the two dimensional semiconductors. PMID:28378761

  10. Hydrothermal preparation of zeolite Li-A and ion exchange properties of Cs and Sr in salt waste

    International Nuclear Information System (INIS)

    Lee, S. H.; Kim, J. G.; Lee, J. H.; Kim, J. H.

    2005-01-01

    An advanced spent fuel management process that were based on Li reduction of the oxide spent fuel to a metallic form will generate a LiCl waste. Zeolite A has been reported as a promising immobilization medium for waste salt with CsCl and SrCl 2 . However, Sodium is accumulated as an ionic form (Na + -ion) in molten salt during ion exchange step between Na + -ion in zeolite A and Li + -ion in the molten salt. Therefore, zeolite Na-A need to be replaced by the Li-type zeolite for recycling the salt waste by removing the Cs and Sr ions. In this study, the hydrothermal preparation of zeolite Li-A was performed in 350ml pressure vessel by P. Norby method. The preparation characteristics of zeolite Li-A was investigated. And the ion exchange properties of Cs and Sr in molten LiCl salt were investigated under the condition of 923K using zeolite 4A and prepared zeolite Li-A

  11. Analgesic effect of continuous femoral nerve block combined with infiltration anesthesia after total knee replacement

    Directory of Open Access Journals (Sweden)

    Jian-Guo Tan

    2016-06-01

    Full Text Available Objective: To study the analgesic effect of continuous femoral nerve block combined with infiltration anesthesia after total knee replacement. Methods: Patients who received unilateral total knee replacement in our hospital from May 2012 to August 2015 were included for study and randomly divided into experimental group who received continuous femoral nerve block combined with infiltration anesthesia and control group who received continuous femoral nerve block, and then the contents of postoperative serum pain-promoting-related mediators, painsuppressing-related mediators and pain-related signal molecules were detected. Results: Serum CGRP, PS, Hist, 5-HT, AM and BK contents of experimental group were significantly lower than those of control group, AEA, β-EP, RvE1, LXA4 and LXB4 contents were significantly higher than those of control group, and P2X2, P2X7, P2X3, P2X4, P2Y1, P2Y2, P2Y4, P2Y6, P2Y 13, P2Y14, p38MAPK and PI3K contents were significantly lower than those of control group. Conclusions: Continuous femoral nerve block combined with infiltration anesthesia after total knee replacement can increase the generation of pain-suppressing mediators, decrease the generation of pain-promoting mediators and achieve more exact analgesic effect.

  12. Three Steam Generator Replacement Projects in 1995

    International Nuclear Information System (INIS)

    Holz, R.; Clavier, G.

    1996-01-01

    Since the companies Siemens AG and Framatome S. A. joined their experience and efforts in the field of steam generator replacements and formed a consortium in 1991, the following projects were performed in 1995: Ringhals 3, Tihange 3 and Asco 1. Further projects will follow in 1996, i. e., Doel 4 and Asco 2. Currently, this European consortium is bidding for the contract to replace the steam generators at the Krsko NPP and hopes to be awarded in 1996. An overview of the way the Consortium Siemens and Framatome approaches SG replacement projects is given based on the projects performed in 1995. Various aspects of project planning, management, licensing, personnel qualification and techniques used on site will be discussed. (author)

  13. REPLACEMENT IN RABBIT HERDS: A REVIEW

    Directory of Open Access Journals (Sweden)

    Ibrahim F.M. Marai

    2010-08-01

    Full Text Available Doe rabbit's replacement constitutes the annual renewal rate of new breeders that must be incorporated into the production stock. Criterion for culling non-productive animals differs significantly among fryer production colonies, foundation stocks and a colony with continuous enzootic disease or continuous malnourishment. In commercial rabbit production, good management improves the health and productivity of the entire herd, by reducing the all-time high replacement rates and improving economic viability. In the present article, a comprehensive review of numerous experiences in the rabbit production field of different countries, was presented. Basic recommendations for professional breeders were highlighted, covering critical issues such as the need for continuously upgrading the health status of the colony, the positive effect of   genetic selection and the nutritional conditioning and special treatment of young does being groomed as future replacements.

  14. Optimal timing for intravascular administration set replacement.

    Science.gov (United States)

    Ullman, Amanda J; Cooke, Marie L; Gillies, Donna; Marsh, Nicole M; Daud, Azlina; McGrail, Matthew R; O'Riordan, Elizabeth; Rickard, Claire M

    2013-09-15

    The tubing (administration set) attached to both venous and arterial catheters may contribute to bacteraemia and other infections. The rate of infection may be increased or decreased by routine replacement of administration sets. This review was originally published in 2005 and was updated in 2012. The objective of this review was to identify any relationship between the frequency with which administration sets are replaced and rates of microbial colonization, infection and death. We searched The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 6), MEDLINE (1950 to June 2012), CINAHL (1982 to June 2012), EMBASE (1980 to June 2012), reference lists of identified trials and bibliographies of published reviews. The original search was performed in February 2004. We also contacted researchers in the field. We applied no language restriction. We included all randomized or controlled clinical trials on the frequency of venous or arterial catheter administration set replacement in hospitalized participants. Two review authors assessed all potentially relevant studies. We resolved disagreements between the two review authors by discussion with a third review author. We collected data for seven outcomes: catheter-related infection; infusate-related infection; infusate microbial colonization; catheter microbial colonization; all-cause bloodstream infection; mortality; and cost. We pooled results from studies that compared different frequencies of administration set replacement, for instance, we pooled studies that compared replacement ≥ every 96 hours versus every 72 hours with studies that compared replacement ≥ every 48 hours versus every 24 hours. We identified 26 studies for this updated review, 10 of which we excluded; six did not fulfil the inclusion criteria and four did not report usable data. We extracted data from the remaining 18 references (16 studies) with 5001 participants: study designs included neonate and adult

  15. Replacement of the JRR-3 computer system

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Tomoaki; Kobayashi, Kenichi; Suwa, Masayuki; Mineshima, Hiromi; Sato, Mitsugu [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2000-10-01

    The JRR-3 computer system contributes to stable operation of JRR-3 since 1990. But now about 10 years have passed since it was designed and some problems have occurred. Under these situations, we should replace the old computer system for safe and stable operation. In this replacement, the system is improved as regards man-machine interface and efficiency about maintenance. The new system consists of three functions, which are 'the function of management for operation information' (renewal function), 'the function of management for facility information' (new function) and the function of management for information publication' (new function). By this replacement, New JRR-3 computer system can contribute to safe and stable operation. (author)

  16. Testosterone Replacement, Muscle Strength, and Physical Function

    Directory of Open Access Journals (Sweden)

    You-Seon Nam

    2018-05-01

    Full Text Available Muscle strength and physical function decrease in older men, as do testosterone levels. Nonetheless, the effects of testosterone replacement therapy on muscle strength and physical function remain inconclusive and equivocal. We conducted a rapid systematic review, the results of which showed that testosterone replacement does not affect muscle strength (measured by hand grip strength and leg muscle strength, although it may increase physical function (measured by the 6-minute walk test, Physical Activity Scale for the Elderly score, and other physical performance tests. However, most of the studies were conducted in the United States or Europe and did not include participants from Asian or other ethnic backgrounds; therefore, further studies are needed to evaluate the effects of testosterone replacement in a broader population.

  17. Dead pixel replacement in LWIR microgrid polarimeters.

    Science.gov (United States)

    Ratliff, Bradley M; Tyo, J Scott; Boger, James K; Black, Wiley T; Bowers, David L; Fetrow, Matthew P

    2007-06-11

    LWIR imaging arrays are often affected by nonresponsive pixels, or "dead pixels." These dead pixels can severely degrade the quality of imagery and often have to be replaced before subsequent image processing and display of the imagery data. For LWIR arrays that are integrated with arrays of micropolarizers, the problem of dead pixels is amplified. Conventional dead pixel replacement (DPR) strategies cannot be employed since neighboring pixels are of different polarizations. In this paper we present two DPR schemes. The first is a modified nearest-neighbor replacement method. The second is a method based on redundancy in the polarization measurements.We find that the redundancy-based DPR scheme provides an order-of-magnitude better performance for typical LWIR polarimetric data.

  18. Replacement of the JRR-3 computer system

    International Nuclear Information System (INIS)

    Kato, Tomoaki; Kobayashi, Kenichi; Suwa, Masayuki; Mineshima, Hiromi; Sato, Mitsugu

    2000-01-01

    The JRR-3 computer system contributes to stable operation of JRR-3 since 1990. But now about 10 years have passed since it was designed and some problems have occurred. Under these situations, we should replace the old computer system for safe and stable operation. In this replacement, the system is improved as regards man-machine interface and efficiency about maintenance. The new system consists of three functions, which are 'the function of management for operation information' (renewal function), 'the function of management for facility information' (new function) and the function of management for information publication' (new function). By this replacement, New JRR-3 computer system can contribute to safe and stable operation. (author)

  19. Postmenopausal hormone replacement therapy--clinical implications

    DEFF Research Database (Denmark)

    Ravn, S H; Rosenberg, J; Bostofte, E

    1994-01-01

    The menopause is defined as cessation of menstruation, ending the fertile period. The hormonal changes are a decrease in progesterone level, followed by a marked decrease in estrogen production. Symptoms associated with these hormonal changes may advocate for hormonal replacement therapy....... This review is based on the English-language literature on the effect of estrogen therapy and estrogen plus progestin therapy on postmenopausal women. The advantages of hormone replacement therapy are regulation of dysfunctional uterine bleeding, relief of hot flushes, and prevention of atrophic changes...... in the urogenital tract. Women at risk of osteoporosis will benefit from hormone replacement therapy. The treatment should start as soon after menopause as possible and it is possible that it should be maintained for life. The treatment may be supplemented with extra calcium intake, vitamin D, and maybe calcitonin...

  20. Severe Heterotopic Ossification following Total Knee Replacement

    Directory of Open Access Journals (Sweden)

    Alexander L. Dodds

    2014-01-01

    Full Text Available Although the incidence of minor heterotopic ossification is probably higher than what is usually expected, severe heterotopic ossification (HO is an extremely rare event following total knee replacement surgery. We present the case of a 66-year-old woman who initially had achieved an excellent range of motion following bilateral uncemented rotating platform total knee replacement, before presenting with pain and loss of range of motion at 2 months after surgery. Severe HO was diagnosed on X-rays. Treatment consisted of nonoperative measures only, including physiotherapy with hydrotherapy and anti-inflammatories. She eventually regained her range of motion when seen at 8 months after operation. This case illustrates that nonoperative treatment without the use of radiotherapy or surgery can be used to safely resolve stiffness caused by HO after total knee replacement.

  1. Imaging techniques in transcatheter aortic valve replacement

    Directory of Open Access Journals (Sweden)

    Quaife RA

    2013-11-01

    Full Text Available Robert A Quaife, Jennifer Dorosz, John C Messenger, Ernesto E Salcedo Division of Cardiology, University of Colorado, Aurora, CO, USA Abstract: Calcific aortic stenosis is now understood as a complex valvular degenerative process sharing many risk factors with atherosclerosis. Once patients develop symptomatic calcific aortic stenosis, the only effective treatment is aortic valve replacement. In the past decade, transcatheter aortic valve replacement (TAVR has been developed as an alternative to surgery to treat severe calcific aortic stenosis. Cardiac imaging plays a pivotal role in the contemporary management of patients with calcific aortic stenosis, and particularly in patients being considered for TAVR, who demand detailed imaging of the aortic valve apparatus. In this review, we highlight the role of cardiac imaging for patient selection, procedural guidance, and evaluation of results of TAVR. Keywords: aortic stenosis, cardiovascular imaging, transcutaneous aortic valve replacement

  2. Solar Thermochemical Energy Storage Through Carbonation Cycles of SrCO3/SrO Supported on SrZrO3.

    Science.gov (United States)

    Rhodes, Nathan R; Barde, Amey; Randhir, Kelvin; Li, Like; Hahn, David W; Mei, Renwei; Klausner, James F; AuYeung, Nick

    2015-11-01

    Solar thermochemical energy storage has enormous potential for enabling cost-effective concentrated solar power (CSP). A thermochemical storage system based on a SrO/SrCO3 carbonation cycle offers the ability to store and release high temperature (≈1200 °C) heat. The energy density of SrCO3/SrO systems supported by zirconia-based sintering inhibitors was investigated for 15 cycles of exothermic carbonation at 1150 °C followed by decomposition at 1235 °C. A sample with 40 wt % of SrO supported by yttria-stabilized zirconia (YSZ) shows good energy storage stability at 1450 MJ m(-3) over fifteen cycles at the same cycling temperatures. After further testing over 45 cycles, a decrease in energy storage capacity to 1260 MJ m(-3) is observed during the final cycle. The decrease is due to slowing carbonation kinetics, and the original value of energy density may be obtained by lengthening the carbonation steps. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells.

    Directory of Open Access Journals (Sweden)

    Yue Ma

    Full Text Available The inverse F-BAR (IF-BAR domain proteins srGAP1, srGAP2 and srGAP3 are implicated in neuronal development and may be linked to mental retardation, schizophrenia and seizure. A partially overlapping expression pattern and highly similar protein structures indicate a functional redundancy of srGAPs in neuronal development. Our previous study suggests that srGAP3 negatively regulates neuronal differentiation in a Rac1-dependent manner in mouse Neuro2a cells. Here we show that exogenously expressed srGAP1 and srGAP2 are sufficient to inhibit valporic acid (VPA-induced neurite initiation and growth in the mouse Neuro2a cells. While ectopic- or over-expression of RhoGAP-defective mutants, srGAP1(R542A and srGAP2(R527A exert a visible inhibitory effect on neuronal differentiation. Unexpectedly, knockdown of endogenous srGAP2 fails to facilitate the neuronal differentiation induced by VPA, but promotes neurite outgrowth of differentiated cells. All three IF-BAR domains from srGAP1-3 can induce filopodia formation in Neuro2a, but the isolated IF-BAR domain from srGAP2, not from srGAP1 and srGAP3, can promote VPA-induced neurite initiation and neuronal differentiation. We identify biochemical and functional interactions of the three srGAPs family members. We propose that srGAP3-Rac1 signaling may be required for the effect of srGAP1 and srGAP2 on attenuating neuronal differentiation. Furthermore, inhibition of Slit-Robo interaction can phenocopy a loss-of-function of srGAP3, indicating that srGAP3 may be dedicated to the Slit-Robo pathway. Our results demonstrate the interplay between srGAP1, srGAP2 and srGAP3 regulates neuronal differentiation and neurite outgrowth. These findings may provide us new insights into the possible roles of srGAPs in neuronal development and a potential mechanism for neurodevelopmental diseases.

  4. Radiological evaluation of failed total hip replacement

    International Nuclear Information System (INIS)

    Raspa, V.; Aldrovandi, S.; Pompei, G.

    1988-01-01

    The retrospective study of 50 operated cases of cemented total hip replacement and a review of the literature enabled the authors to define the radiological features of the above-mentioned condition. These features include one or more of the following signs: calcar reabsorption, lacunar erosions, modified relatioships between the prosthesis components, sepsis and loosening, periarticular calcifications dislocation and fracture of prosthesis components. Careful evaluation of these radiological features is extremely important for both an early diagnosis of failed total hip replacement and the choice of an adequate surgical treatment

  5. Criteria for the replacement of restorations

    DEFF Research Database (Denmark)

    Wilson, Nairn; Lynch, Christopher; Brunton, Paul Brunton

    2016-01-01

    The replacement of a restoration is one of the most common procedures in dentistry. However, the criteria for such intervention, excluding catastrophic failure and persistent discomfort and pain, continue to be the subject of considerable debate. The decision-making process remains subjective...... on the part of the treating clinician, while the evidence base for refurbishment and repair rather than replacement for the management of defective and failing restorations continues to grow and strengthen. This article, prepared as an Academy of Operative Dentistry European Section consensus publication...

  6. Fuzzy logic application for extruders replacement problem

    Directory of Open Access Journals (Sweden)

    Edison Conde Perez dos Santos

    2017-03-01

    Full Text Available In a scenario of uncertainty and imprecision, before taking the replacement analysis, a manager needs to consider the uncertain reality of a problem. In this scenario, the fuzzy logic makes an excellent option. Therefore, it is necessary to make a decision based on the fuzzy model. This study is based on the comparison of two methodologies used in the problem of asset replacement. The study, thus, was based on a comparison between two extruders for polypropylene yarn bibliopegy, comparing mainly the costs involved in maintaining the equipment.

  7. Valve assembly having remotely replaceable bearings

    International Nuclear Information System (INIS)

    Johnson, E.R.; Tanner, D.E.

    1980-01-01

    A valve assembly having remotely replaceable bearings is disclosed wherein a valve disc is supported within a flow duct for rotation about a pair of axially aligned bearings, one of which is carried by a spindle received within a diametral bore in the valve disc, and the other of which is carried by a bearing support block releasably mounted on the duct circumferentially of an annular collar on the valve disc coaxial with its diametrical bore. The spindle and bearing support block are adapted for remote removal to facilitate servicing or replacement of the valve disc support bearings

  8. 87Sr/86Sr variations in basalts of Late Eocene-Early Miocene series in Eastern Sikhoteh-Alin

    International Nuclear Information System (INIS)

    Esin, S.V.; Ponomarchuk, V.A.; Shipitsyn, Yu.G.; Palesskij, Yu.G.

    1993-01-01

    Late Eocene high-alumina and Oligocene high-alumina and magnesian basalts of the Neogene calc-alkaline series from the Eastern Sikhoteh-Alin are shown to have the following 87 Sr/ 86 Sr ratios: 0.70390-0.70465; 0.70347-0.70401, and the 0.70330-0.70347. Analysis of variations of Sr ratios, REE, HFSE, and LILE suggests that they are the products of successive melting of a multicomponent source containing the peridotite material of OIB- and MORB-types altered by fluids to a different degree and the pelagic sediments

  9. ACTH Regulation of Adrenal SR-B1

    Directory of Open Access Journals (Sweden)

    Wen-Jun eShen

    2016-05-01

    Full Text Available The adrenal gland is one of the prominent sites for steroid hormone synthesis. Lipoprotein-derived cholesterol esters delivered via scavenger receptor, class B type 1 (SR-B1 constitute the dominant source of cholesterol for steroidogenesis, particularly in rodents. ACTH stimulates steroidogenesis through downstream actions on multiple components involved in steroidogenesis. Both acute and chronic ACTH treatment can modulate SR-B1 function including its transcription, its post transcriptional stability, its phosphorylation and dimerization status, as well as its interaction with other protein partners; all of which result in changes in the ability of SR-B1 to mediate HDL-cholesterol ester uptake and the supply of cholesterol for conversion to steroids. Here we provide a review of the recent findings on the regulation of adrenal SR-B1 function by ACTH.

  10. Gibbs energy formation of Sr5Nb4O15

    International Nuclear Information System (INIS)

    Samui, Pradeep; Padhi, Anyuna; Agarwal, Renu; Kulkarni, S.G.

    2012-01-01

    Ternary oxides of strontium and niobium may form as fission product compounds in an operating nuclear reactor with oxide fuels under certain oxygen potential. Evaluations of thermodynamic stability of these ternary oxides are therefore important for assessment of fission product interactions. Furthermore, thermodynamic data of these oxides are also of relevance because of computation of phase diagram and phase stability of pseudo-ternary systems BaO-SrO-Nb 2 O 5 , SrO-Nb 2 O 5 -TaO 5 etc. in which some of the compounds are potential candidate materials for microwave ceramics with high dielectric constant, electro-optic, pyroelectric and piezoelectric devices. The system Sr-Nb-O contains many ternary oxides out of which we have investigated the thermodynamic parameters for the compound Sr 5 Nb 4 O 15 in the present study

  11. Precessional control of Sr ratios in marginal basins during the Messinian Salinity Crisis?

    NARCIS (Netherlands)

    Topper, R.P.M.; Lugli, S.; Manzi, V.; Roveri, M.; Meijer, P.Th.

    Based on 87Sr/86Sr data of the Primary Lower Gypsum (PLG) deposits in the Vena del Gesso basin—a marginal basin of the Mediterranean during the Messinian Salinity Crisis—a correlation between 87Sr/86Sr values and precessional forcing has recently been proposed but not yet confirmed. In this study, a

  12. The impact of Mg contents on Sr partitioning in benthic foraminifers

    NARCIS (Netherlands)

    Mewes, Antje; Langer, Gerald; Reichart, Gert Jan; de Nooijer, L.J.; Nehrke, Gernot; Bijma, Jelle

    2015-01-01

    Foraminiferal calcite Mg/Ca (Mg/CaCC) is used in paleoceanographic studies to reconstruct temperature. Furthermore, the Mg/CaCC is influenced by different seawater Mg/Ca (Mg/CaSW). Foraminiferal calcite Sr/Ca (Sr/CaCC) can potentially be used to reconstruct Sr/Ca ratios of seawater (Sr/CaSW). As

  13. Alginate prevention of internal irradiation with 90Sr

    International Nuclear Information System (INIS)

    Korzun, V.N.; Voronova, Yu.G.; Parats, A.N.; Podkorytova, A.V.; Rogal'skaya, L.A.; Saglo, V.I.; Skorikova, A.I.

    1992-01-01

    Recipes of foodstaffs (meat and vegetable preserves, bread, pastry, dairy products, etc.) containing sodium or calcium alginates in doses 0.5-3.0 g have been developed. Experiments with white rats have demonstrated that addition of such products to daily radions of these animals reduced 2-4-fold the accumulation of radioactive Sr taken daily with food for 30 days. Alginates and Crambe added to food preserve their ability to reduce the accumulation of radioactive Sr

  14. Interim process report for the safety assessment SR-Can

    International Nuclear Information System (INIS)

    Sellin, Patrick

    2004-08-01

    This report is a documentation of buffer processes identified as relevant to the long-term safety of a KBS-3 repository. The report is part of the interim reporting of the safety assessment SR-Can, see further the Interim main report. The final SR-Can reporting will support SKB's application to build an Encapsulation plant for spent nuclear fuel and is to be produced in 2006. The purpose of this report is to document the scientific knowledge of the processes to a level required for an adequate treatment in the safety assessment. The documentation is thus from a scientific point of not exhaustive since such a treatment is neither necessary for the purposes of the safety assessment nor possible within the scope of an assessment. The purpose is further to determine the handling of each process in the safety assessment and to demonstrate how uncertainties are taken care of, given the suggested handling. The process documentation in the SR 97 version of the Process report is a starting point for this SR-Can interim version. As further described in the Interim main report, the list of relevant processes has been reviewed and slightly extended by comparison to other databases. Furthermore, the backfill has been included as a system part of its own, rather than being described together with the buffer as in SR 97. Apart from giving an interim account of the documentation and handling of buffer processes in SR-Can, this report is meant to serve as a template for the forthcoming documentation of processes occurring in other parts of the repository system. A complete list of processes can be found in the Interim FEP report for the safety assessment SR-Can. All material presented in this document is preliminary in nature and will possibly be updated as the SR-Can project progresses

  15. Determination of {sup 90}Sr in uranium fission products

    Energy Technology Data Exchange (ETDEWEB)

    Bajo, S; Tobler, L [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1996-02-01

    A previously published radiochemical procedure for the determination of {sup 90}Sr in grass and soil has been successfully employed - with minor modifications - for the determination of this nuclide in a solution of uranium fission products. It is suitable for the determination of {sup 90}Sr in environmental materials following a nuclear accident. The procedure is based on tributylphosphate extraction of {sup 90}Y, precipitation of Y-oxalate, and counting in a proportional counter. (author) figs., tabs., 10 refs.

  16. Nuclear safety activities in SR Slovenia in 1985

    International Nuclear Information System (INIS)

    1986-09-01

    Currently Yugoslavia has one 632 MWe nuclear power plant of PWR design, located at Krsko in the Socialist Republic of Slovenia. NPP Krsko, which is a two-loop plant, started power operation in 1981. In general, reactor safety activities in SR Slovenia are mostly related to upgrading the safety of our NPP Krsko and to develop capabilities to be used for the future units. This report presents safety related organizations in SR Slovenia and their activities performed in 1985. (author)

  17. Rb-Sr geochronology of some Miocene West Australian lamproites

    International Nuclear Information System (INIS)

    Allsopp, H.L.; Scott Smith, B.H.; Danchin, R.V.

    1985-01-01

    Rb-Sr ages are presented for four lamproite intrusions (Mount North, Old Leopold Hill, Mount Rose and Seltrust Pipe 2) located in the west Kimberley region of West Australia. The data are in agreement with the early Miocene ages previously obtained for the lamproites of this area. The lamproites are characterized by high initial-Sr ratios, indicative of derivation from an enriched source. Localized and regional mantle heterogeneity is indicated by new and existing data

  18. Interim process report for the safety assessment SR-Can

    Energy Technology Data Exchange (ETDEWEB)

    Sellin, Patrick (ed.)

    2004-08-01

    This report is a documentation of buffer processes identified as relevant to the long-term safety of a KBS-3 repository. The report is part of the interim reporting of the safety assessment SR-Can, see further the Interim main report. The final SR-Can reporting will support SKB's application to build an Encapsulation plant for spent nuclear fuel and is to be produced in 2006. The purpose of this report is to document the scientific knowledge of the processes to a level required for an adequate treatment in the safety assessment. The documentation is thus from a scientific point of not exhaustive since such a treatment is neither necessary for the purposes of the safety assessment nor possible within the scope of an assessment. The purpose is further to determine the handling of each process in the safety assessment and to demonstrate how uncertainties are taken care of, given the suggested handling. The process documentation in the SR 97 version of the Process report is a starting point for this SR-Can interim version. As further described in the Interim main report, the list of relevant processes has been reviewed and slightly extended by comparison to other databases. Furthermore, the backfill has been included as a system part of its own, rather than being described together with the buffer as in SR 97. Apart from giving an interim account of the documentation and handling of buffer processes in SR-Can, this report is meant to serve as a template for the forthcoming documentation of processes occurring in other parts of the repository system. A complete list of processes can be found in the Interim FEP report for the safety assessment SR-Can. All material presented in this document is preliminary in nature and will possibly be updated as the SR-Can project progresses.

  19. The cellular cancer resistance of the SR/CR mouse

    DEFF Research Database (Denmark)

    Koch, Janne; Hau, Jann; Jensen, Henrik Elvang

    2012-01-01

    The SR/CR mouse phenotype, first described in 1999 in BALB/c and later bred into C57BL/6 mice, is resistant to cancer formation following high doses of cancer cells administered intraperitoneally. The tumor cell targeting and destruction mechanisms have not been identified. By fluorescence-activa...... controls. Importantly, this differentially regulated immune response of SR/CR mice could not be found in response to challenge with the lymphoma cell line EL-4....

  20. Nuclear safety activities in SR Slovenia in 1985

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-09-15

    Currently Yugoslavia has one 632 MWe nuclear power plant of PWR design, located at Krsko in the Socialist Republic of Slovenia. NPP Krsko, which is a two-loop plant, started power operation in 1981. In general, reactor safety activities in SR Slovenia are mostly related to upgrading the safety of our NPP Krsko and to develop capabilities to be used for the future units. This report presents safety related organizations in SR Slovenia and their activities performed in 1985. (author)

  1. MANAGEMENT OF FAILED MITRAL VALVE REPLACEMENT. THE DURBAN EXPERIENCE.

    Science.gov (United States)

    Kistan, D; Booysen, M; Alexander, G; Madiba, T E

    2017-06-01

    Mitral valve replacement is the procedure of choice in patients with severe mitral valve disease. However, these patients are surviving longer and are thus at an increased risk of prosthesis failure or valve-related complications. Study setting: Inkosi Albert Luthuli Central Hospital, a tertiary referral Hospital in Durban. Study population: All patients undergoing redo mechanical mitral valve replacement surgery between January 2005 and December 2014. Study design: Retrospective analysis of patients undergoing redo mitral valve replacement. Patients were identified from theatre record books, their files were electronically accessed and pertinent information extracted onto a data capture sheet. Information documented included demographics, duration to failure, INR, Albumin, HIV status, clinical findings and outcome. The data was stored on an Excel datasheet. Fifty-eight patients were documented (mean age 32 ± 15.81 years; M:F 1:3). Ten patients (17%) were HIV positive (median CD4 count 478). Mean duration between first surgery and redo was 8.8 years. Thirty-five patients (60%) had no co-morbidities. Presenting features at redo surgery were congestive cardiac failure (27), chest pain (11) and palpitations (17). Mean preoperative Ejection Fraction was 51.65 %. Twenty-nine patients (55%) had emergency redo surgery. Twenty-two patients (75%) had acute prosthetic valve thrombosis. Thirty-two patients had tricuspid regurgitation. Original pathology was documented in 23 patients (40%) as Rheumatic valve disease. Prosthetic valve thrombosis was documented in 31 patients (54%). The most commonly used valve was the On-X. Mean presenting INR was 1.96 + 1.2 and mean presenting serum albumin was 36.7 + 7.8 g/l. Forty-one patients (71%) were found to be compliant to Warfarin therapy prior to redo surgery. Mean ICU stay was 6 +9 days. Two patients died postoperatively. Mean followup was 32 + 26.6 months. Twelve patients (20.7%) developed postoperative complications. Patients

  2. Determining the Cost-Savings Threshold and Alignment Accuracy of Patient-Specific Instrumentation in Total Ankle Replacements.

    Science.gov (United States)

    Hamid, Kamran S; Matson, Andrew P; Nwachukwu, Benedict U; Scott, Daniel J; Mather, Richard C; DeOrio, James K

    2017-01-01

    Traditional intraoperative referencing for total ankle replacements (TARs) involves multiple steps and fluoroscopic guidance to determine mechanical alignment. Recent adoption of patient-specific instrumentation (PSI) allows for referencing to be determined preoperatively, resulting in less steps and potentially decreased operative time. We hypothesized that usage of PSI would result in decreased operating room time that would offset the additional cost of PSI compared with standard referencing (SR). In addition, we aimed to compare postoperative radiographic alignment between PSI and SR. Between August 2014 and September 2015, 87 patients undergoing TAR were enrolled in a prospectively collected TAR database. Patients were divided into cohorts based on PSI vs SR, and operative times were reviewed. Radiographic alignment parameters were retrospectively measured at 6 weeks postoperatively. Time-driven activity-based costing (TDABC) was used to derive direct costs. Cost vs operative time-savings were examined via 2-way sensitivity analysis to determine cost-saving thresholds for PSI applicable to a range of institution types. Cost-saving thresholds defined the price of PSI below which PSI would be cost-saving. A total of 35 PSI and 52 SR cases were evaluated with no significant differences identified in patient characteristics. Operative time from incision to completion of casting in cases without adjunct procedures was 127 minutes with PSI and 161 minutes with SR ( P cost-savings threshold range at our institution of $863 below which PSI pricing would provide net cost-savings. Two-way sensitivity analysis generated a globally applicable cost-savings threshold model based on institution-specific costs and surgeon-specific time-savings. This study demonstrated equivalent postoperative TAR alignment with PSI and SR referencing systems but with a significant decrease in operative time with PSI. Based on TDABC and associated sensitivity analysis, a cost-savings threshold

  3. Use of Renal Replacement Therapy May Influence Graft Outcomes following Liver Transplantation for Acute Liver Failure: A Propensity-Score Matched Population-Based Retrospective Cohort Study.

    Science.gov (United States)

    Knight, Stephen R; Oniscu, Gabriel C; Devey, Luke; Simpson, Kenneth J; Wigmore, Stephen J; Harrison, Ewen M

    2016-01-01

    Acute kidney injury is associated with a poor prognosis in acute liver failure but little is known of outcomes in patients undergoing transplantation for acute liver failure who require renal replacement therapy. A retrospective analysis of the United Kingdom Transplant Registry was performed (1 January 2001-31 December 2011) with patient and graft survival determined using Kaplan-Meier methods. Cox proportional hazards models were used together with propensity-score based full matching on renal replacement therapy use. Three-year patient and graft survival for patients receiving renal replacement therapy were 77.7% and 72.6% compared with 85.1% and 79.4% for those not requiring renal replacement therapy (Prenal replacement therapy was a predictor of both patient death (hazard ratio (HR) 1.59, 95% CI 1.01-2.50, P = 0.044) but not graft loss (HR 1.39, 95% CI 0.92-2.10, P = 0.114). In groups fully matched on baseline covariates, those not receiving renal replacement therapy with a serum creatinine greater than 175 μmol/L had a significantly worse risk of graft failure than those receiving renal replacement therapy. In patients being transplanted for acute liver failure, use of renal replacement therapy is a strong predictor of patient death and graft loss. Those not receiving renal replacement therapy with an elevated serum creatinine may be at greater risk of early graft failure than those receiving renal replacement therapy. A low threshold for instituting renal replacement therapy may therefore be beneficial.

  4. Decoupling of unpolluted temperate forests from rock nutrient sources revealed by natural 87Sr/86Sr and 84Sr tracer addition

    Science.gov (United States)

    Kennedy, Martin J.; Hedin, Lars O.; Derry, Louis A.

    2002-01-01

    An experimental tracer addition of 84Sr to an unpolluted temperate forest site in southern Chile, as well as the natural variation of 87Sr/86Sr within plants and soils, indicates that mechanisms in shallow soil organic horizons are of key importance for retaining and recycling atmospheric cation inputs at scales of decades or less. The dominant tree species Nothofagus nitida feeds nearly exclusively (>90%) on cations of atmospheric origin, despite strong variations in tree size and location in the forest landscape. Our results illustrate that (i) unpolluted temperate forests can become nutritionally decoupled from deeper weathering processes, virtually functioning as atmospherically fed ecosystems, and (ii) base cation turnover times are considerably more rapid than previously recognized in the plant available pool of soil. These results challenge the prevalent paradigm that plants largely feed on rock-derived cations and have important implications for understanding sensitivity of forests to air pollution. PMID:12119394

  5. Novel approaches for 90Sr analyses in contaminated environmental samples

    International Nuclear Information System (INIS)

    Kavasi, N.; Sahoot, S.K.; Area, H.; Aono, T.

    2016-01-01

    Radioactive strontium isotopes are generated with high cumulative fission yield (5-6 %) during thermal neutron fission in a nuclear reactor. The physical half-life of 89 Sr (50.52 d) is short but that of 90 Sr (28.8 y) is long enough to generate radioecological repercussions. 90 Sr has a long-lasting biological half-life (∼18 y) in the human body, due to its chemical similarity to calcium the importance of 90 Sr analysis is emphasized in case of a nuclear disaster. The world-wide spread of 90 Sr, as a background, is derived from the global atmospheric fallout contributed by large-scale atmospheric nuclear weapons tests conducted from 1945. In case of local contamination, nuclear accidents are not the only source of 90 Sr isotope, misconducted underground nuclear weapon tests; improper handling of by-products of nuclear weapon production or normal operation of nuclear facilities (e.g. reprocessing plants) can be taken into account

  6. FEP report for the safety assessment SR-Can

    Energy Technology Data Exchange (ETDEWEB)

    Skagius, Kristina [Kemakta Konsult AB, Stockholm (Sweden)

    2006-11-15

    This report documents the analysis and processing of features, events and processes, FEPs, that has been carried out within the safety assessment SR-Can, and forms an important part of the reporting of the project. The SR-Can project is a preparatory stage for the SR-Site assessment, and the report from that project will be used in support of SKB's application to build a final repository. The overall objective of the FEP analysis and processing included development of a database of features, events and processes, an SKB FEP database, in a format that facilitates both a systematic analysis of FEPs and documentation of that FEP analysis, as well as facilitating revisions and updates to be made in connection with new safety assessments. The overall objective also extended to the development of procedures for such a systematic FEP analysis as well as the application of those procedures in order to establish an SR-Can FEP catalogue within the framework of the SKB FEP database. The work started by implementing the content of the SR 97 Process Report into a database format suitable for import and processing of FEP information from other sources. The SR 97 version of the database was systematically audited against the NEA database with Project FEPs, version 1.2. In addition, an earlier audit of the SR 97 process report against the interaction matrices developed for a deep repository of the KBS-3 type was revisited and updated. Relevant FEPs identified through the audit process were sorted into three main categories i) FEPs related to the initial states of the repository system, ii) FEPs related to internal processes of the repository system, and iii) FEPs related to external impacts on the repository system. This resulted in additions to the SR 97 list of processes and to the lists of initial state FEPs and external factors to be addressed in further processing. The further processing of the initial state FEPs revealed that those FEPs that are not covered by the

  7. FEP report for the safety assessment SR-Can

    International Nuclear Information System (INIS)

    Skagius, Kristina

    2006-11-01

    This report documents the analysis and processing of features, events and processes, FEPs, that has been carried out within the safety assessment SR-Can, and forms an important part of the reporting of the project. The SR-Can project is a preparatory stage for the SR-Site assessment, and the report from that project will be used in support of SKB's application to build a final repository. The overall objective of the FEP analysis and processing included development of a database of features, events and processes, an SKB FEP database, in a format that facilitates both a systematic analysis of FEPs and documentation of that FEP analysis, as well as facilitating revisions and updates to be made in connection with new safety assessments. The overall objective also extended to the development of procedures for such a systematic FEP analysis as well as the application of those procedures in order to establish an SR-Can FEP catalogue within the framework of the SKB FEP database. The work started by implementing the content of the SR 97 Process Report into a database format suitable for import and processing of FEP information from other sources. The SR 97 version of the database was systematically audited against the NEA database with Project FEPs, version 1.2. In addition, an earlier audit of the SR 97 process report against the interaction matrices developed for a deep repository of the KBS-3 type was revisited and updated. Relevant FEPs identified through the audit process were sorted into three main categories i) FEPs related to the initial states of the repository system, ii) FEPs related to internal processes of the repository system, and iii) FEPs related to external impacts on the repository system. This resulted in additions to the SR 97 list of processes and to the lists of initial state FEPs and external factors to be addressed in further processing. The further processing of the initial state FEPs revealed that those FEPs that are not covered by the

  8. Nature and Significance of the High-Sr Aleutian Lavas

    Science.gov (United States)

    Yogodzinski, G. M.; Arndt, S.; Turka, J. R.; Kelemen, P. B.; Vervoort, J. D.; Portnyagin, M.; Hoernle, K.

    2011-12-01

    Results of the Western Aleutian Volcano Expedition and German-Russian KALMAR cruises include the discovery of seafloor volcanism at the Ingenstrem Depression and at unnamed seamounts 300 km west of Buldir, the westernmost emergent volcano in the Aleutian arc. These discoveries indicate that the surface expression of active Aleutian volcanism goes below sea level just west of Buldir, but is otherwise continuous along the full length of the arc. Many lavas dredged from western Aleutian seamounts are basalts, geochemically similar to basalts from elsewhere in Aleutians and other arcs (La/Yb 4-8, Sr/Y700 ppm Sr), which are mostly plagioclase-hornblende andesites and dacites with low Y and middle-heavy rare-earth elements, fractionated trace element patterns (Sr/Y=50-200, La/Yb=9-25) and MORB-like isotopes (87Sr/86Sr 0.65) with 1250-1700 ppm Sr, 4-7 ppm Y, low abundances of all rare-earth elements (LaMexico. [1] Zimmer et al., 2010, J. Petrology, v. 51, p. 2411

  9. Cs-137 and Sr-90 level in diary products

    International Nuclear Information System (INIS)

    Petukhov, V.L.; Dukhanov, Y.A.; Sevryuk, I.Z.; Patrashkov, S.A.; Korotkevich, O.S.; Gorb, T.S.; Petukhov, I.V.

    2003-01-01

    About 70% of radioactive substances fell on the territory of the Byelorussian Republic after the Chernobyl Atom Power Station Disaster. Cs-137 and Sr-90 accumulation dynamics was studied in milk of the cows from the highest polluted Braginsky area. 408 milk samples of Black and White cows were investigated. In 1995 average Cs-137 and Sr-90 levels were 61.00 and 3.73 Bk/dm 3 respectively. Cs-137 and Sr-90 levels exceeded Byelorussian Republic upper limits RDU - 96 in 10 and 50% of milk samples respectively. After 5 years (by 2000) Cs-137 and Sr-90 levels had become almost 3 and 2 times less (21.70 Bk/dm 3 and 1.72 Bk/dm 3 respectively). Cs-137 and Sr-90 levels exceeded RDU - 96 in 1.5 and 5.5% of milk samples respectively. In the same periods Cs-137 and Sr-90 levels were 7 and 2 times higher than the similar indexes in the relatively clean Novosibirsk area. Thus, radioactive element levels in milk of Black and White cows of the Byelorussian Republic decreased significantly for the past years. (authors)

  10. The Replacement Operation for CCP Programs

    NARCIS (Netherlands)

    Bertolino, Marco; Etalle, Sandro; Palamidessi, Catuscia

    1999-01-01

    The Replacement is a very powerful transformation operation which - both within the functional paradigm as well as within the logic programming one - can micic the most common transformation operations such as unfold, fold, switching, distribution. Because of this flexibility , it can be incorrect

  11. Rapid replacement/construction of bridges.

    Science.gov (United States)

    2012-11-01

    Bridges are a key element of the transportation system because they control system capacity and are normally built at : the highest cost to the system. Once a bridge reaches its useful design service life, it needs to be replaced or : reconstructed i...

  12. The Replacement Operation for CCP Programs

    NARCIS (Netherlands)

    Bertolino, Marco; Bossi, Annalisa; Etalle, Sandro; Palamidessi, Catuscia

    2000-01-01

    The Replacement is a very powerful transformation operation which - both within the functional paradigm as well as within the logic programming one - can micic the most common transformation operations such as unfold, fold, switching, distribution. Because of this flexibility , it can be incorrect

  13. Prosthesis infections after orthopedic joint replacement

    DEFF Research Database (Denmark)

    Song, Zhijun; Borgwardt, Lotte; Høiby, Niels

    2013-01-01

    Prosthesis-related infection is a serious complication for patients after orthopedic joint replacement, which is currently difficult to treat with antibiotic therapy. Consequently, in most cases, removal of the infected prosthesis is the only solution to cure the infection. It is, therefore...

  14. Strategic Capital Budgeting : Asset Replacement Under Uncertainty

    NARCIS (Netherlands)

    Pawlina, G.; Kort, P.M.

    2001-01-01

    We consider a firm's decision to replace an existing production technology with a new, more cost-efficient one.Kulatilaka and Perotti [1998, Management Science] nd that, in a two-period model, increased product market uncertainty could encourage the firm to invest strategically in the new

  15. Central alarm system replacement in NPP Krsko

    International Nuclear Information System (INIS)

    Cicvaric, D.; Susnic, M.; Djetelic, N.

    2004-01-01

    Current NPP Krsko central alarm system consists of three main segments. Main Control Board alarm system (BETA 1000), Ventilation Control Board alarm system (BETA 1000) and Electrical Control Board alarm system (BETA 1100). All sections are equipped with specific BetaTone audible alarms and silence, acknowledge as well as test push buttons. The main reason for central alarm system replacement is system obsolescence and problems with maintenance, due to lack of spare parts. Other issue is lack of system redundancy, which could lead to loss of several Alarm Light Boxes in the event of particular power supply failure. Current central alarm system does not provide means of alarm optimization, grouping or prioritization. There are three main options for central alarm system replacement: Conventional annunciator system, hybrid annunciator system and advanced alarm system. Advanced alarm system implementation requires Main Control Board upgrade, integration of process instrumentation and plant process computer as well as long time for replacement. NPP Krsko has decided to implement hybrid alarm system with patchwork approach. The new central alarm system will be stand alone, digital, with advanced filtering and alarm grouping options. Sequence of event recorder will be linked with plant process computer and time synchronized with redundant GPS signal. Advanced functions such as link to plant procedures will be implemented with plant process computer upgrade in outage 2006. Central alarm system replacement is due in outage 2004.(author)

  16. of surfactant replacement therapy at Johannesburg Hospital ...

    African Journals Online (AJOL)

    To assess the impact of surfactant replacement therapy (SRl) on the outcome of ... oxygen requirements) was compared with that of a historical control group of ... The use of SRT added to the total cost of treating a patient ventilated for HMD.

  17. vein thrombosis in elective hip replacement

    African Journals Online (AJOL)

    A consensus forum was convened to evaluate the economic considerations associated with prophylaxis against thrombo-embolic disease in patients undergoing hip replacement therapy in South Africa. This forum consists of orthopaedic surgeons, vascular surgeons and a statistician. Methods. The forum was instructed to ...

  18. Mechanical Aortic Valve Replacement in Octogenarian

    Directory of Open Access Journals (Sweden)

    Irfan Tasoglu

    2013-10-01

    Full Text Available Aim: This study analyzes the long-term outcomes of mechanical aortic valve replacement in octogenarian patients. Material and Method: A retrospective review was performed on 23 octogenarian patients who underwent mechanical aortic valve replacement. Hospital mortality, postoperative intensive care unit stay, hospital stay and long-term results was examined. Estimates of the cumulative event mortality rate were calculated by the Kaplan-Meier method. Results: The mean age of all patients was 82.9±2.3 years and most were men (65.22%. The median ejection fraction was 45%. 73.91% of patients were in New York Heart Association class III-IV. Thirteen patients (56.52% in this study underwent combined procedure, the remaining 10 (43.48% patients underwent isolated aortic valve replacement. The most common valve size was 23 mm. The mean intensive care unit stay was 1.76±1.14 days. The mean hospital stay was 9.33±5.06 days. No complications were observed in 56.52% patients during their hospital stay. The overall hospital mortality was 8.7%. Follow-up was completed for all 23 patients. Median follow-up time was 33 months (1-108 months. Actuarial survival among discharged from hospital was 59% at 5 years. Discussion: Mechanical aortic valve replacement is a safe procedure in octogenarian patients and can be performed safely even in combined procedure.

  19. 5/8'' baffle bolt replacement

    International Nuclear Information System (INIS)

    Pinaud, T.; Grypczynski, D.

    1999-01-01

    Both Framatome Nuclear Services in France and its U.S. arm, FT1, are now equipped with baffle bolt inspection and replacement packages. These packages allow them to tackle baffle bold degradation on both two- and three-loop nuclear power plants. Framatome and FT1 together are world leaders in addressing reactor vessel internal bolting concerns

  20. Optimal strategies for a replacement model

    NARCIS (Netherlands)

    Bruns, P.B.

    2000-01-01

    We examine a replacement system with discrete-time Markovian deterioration and finite state space $\\{0,\\ldots,N\\}$. State 0 stands for a new system, and the higher the state the worse the system; a system in state $N$ is considered to be in a {\\it bad state}. We impose the condition that the

  1. Who Will Replace Those Vanishing Execs?

    Science.gov (United States)

    Geber, Beverly

    2000-01-01

    Many top-level managers are retiring early. Programs to prepare their replacements have been scaled back. Many companies are offering phased retirement plans, redesigning jobs, and paying for spouses to go along on business trips to keep their managers a little longer. (JOW)

  2. Probability Issues in without Replacement Sampling

    Science.gov (United States)

    Joarder, A. H.; Al-Sabah, W. S.

    2007-01-01

    Sampling without replacement is an important aspect in teaching conditional probabilities in elementary statistics courses. Different methods proposed in different texts for calculating probabilities of events in this context are reviewed and their relative merits and limitations in applications are pinpointed. An alternative representation of…

  3. Solid-State Thyratron Replacement. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Roth, Ian [Diversified Technologies, Inc., Bedford, MA

    2017-12-12

    Under this SBIR, DTI developed a solid-state switch as an alternative to legacy thyratron equipment. Our Phase II objective was to make a solid-state thyratron replacement that would provide equivalent or better performance, much higher reliability (at least a 20 year lifetime, compared to a thyratron’s two-year lifetime) and would sell for ~3x the cost of a thyratron, or less than $40k. We were successful in building a solid-state switch which could reliably function as a thyratron replacement. The unit was designed to directly replace the thyratrons currently being used at SLAC’s Linac Coherent Light Source (LCLS), and was built in a tank that was small enough to fit into the existing thyratron cabinet, providing a true form-fit-function replacement path. We tested the switch at the full operating specifications: 48 kV, 6.3 kA, and 1 µs risetime. We also demonstrated a peak-to-peak pulse jitter of 1.5 ns, which is five times shorter than is typical for thyratrons. This lower jitter would improve the performance of the LCLS beam. The predicted reliability is more than 80 years, which is 40 times greater than a thyratron.

  4. Measure Guideline: Window Repair, Rehabilitation, and Replacement

    Energy Technology Data Exchange (ETDEWEB)

    Baker, P.

    2012-12-01

    This measure guideline provides information and guidance on rehabilitating, retrofitting, and replacing existing window assemblies in residential construction. The intent is to provide information regarding means and methods to improve the energy and comfort performance of existing wood window assemblies in a way that takes into consideration component durability, in-service operation, and long term performance of the strategies.

  5. Heart valve replacements with regenerative capacity

    NARCIS (Netherlands)

    Dijkman, P.E.; Fioretta, E.S.; Frese, L.; Pasqualini, F.S.; Hoerstrup, S.P.

    2016-01-01

    The incidence of severe valvular dysfunctions (e.g., stenosis and insufficiency) is increasing, leading to over 300,000 valves implanted worldwide yearly. Clinically used heart valve replacements lack the capacity to grow, inherently requiring repetitive and high-risk surgical interventions during

  6. Older Person's Guide to Joint Replacement

    Science.gov (United States)

    ... who prep for surgery and follow through with physical therapy afterward can further boost their odds of a good outcome. If you’re considering joint replacement surgery, here’s what the experts with the American Geriatrics Society’s Foundation for Health in Aging (FHA) suggest: Ask ...

  7. Continuous vasopressin replacement in diabetes insipidus.

    OpenAIRE

    Ralston, C; Butt, W

    1990-01-01

    Five children who developed diabetes insipidus as a manifestation of severe brain injury received continuous intravenous treatment with a solution containing both aqueous vasopressin and appropriate crystalloid replacement. Polyuria, hypernatraemia, and decreased urine osmolalities were safely corrected in all patients within eight to 28 hours.

  8. Aggression Replacement Training and Childhood Trauma

    Science.gov (United States)

    Amendola, A. Mark; Oliver, Robert W.

    2013-01-01

    Aggression Replacement Training (ART) was developed by the late Arnold Goldstein of Syracuse University to teach positive alternatives to children and youth with emotional and behavioral problems (Glick & Gibbs, 2011; Goldstein, Glick, & Gibbs, 1998). ART provides cognitive, affective, and behavioral interventions to build competence in…

  9. CANDU-PHW fuel channel replacement experience

    International Nuclear Information System (INIS)

    Dunn, J.T.; Kakaria, B.K.

    1982-09-01

    One of the main characteristics of the CANDU pressurized heavy water reactor is the use of pressure tubes rather than one large pressure vessel to contain the fuel and coolant. This provides an inherent design capability to permit their replacement in an expeditious manner, without seriously affecting the high capacity factors of the reactor units. Of th eight Ontario Hydro commercial nuclear generating units, the lifetime performance places seven of them (including two that have had some of their fuel channels replaced), in the top ten positions in the world's large nuclear-electric unit performance ranking. Pressure tube cracks in the rolled joint region have resulted in 70 fuel channels being replaced in three reactor units, the latest being at the Bruce Nuclear Generating Station 'A', Unit 2 in February 1982. The rolled joint design and rolling procedures have been modified to eliminate this problem on CANDU units subsequent to Bruce 'A'. This paper describes the CANDU pressure tube performance history and expectations, and the tooling and procedures used to carry out the fuel channel replacement

  10. Telerehabilitation Feasibility in Total Joint Replacement

    Directory of Open Access Journals (Sweden)

    Mark J. Nelson

    2017-11-01

    Full Text Available Despite documented benefits, many Total Joint Replacement (TJR patients find it difficult to access rehabilitation following discharge from hospital. One solution to improve access for TJR patients is telerehabilitation. This study aimed to assess the feasibility of introducing a telerehabilitation program for TJR patients.   TJR patients at QEII Jubilee Hospital were invited to complete a questionnaire regarding their access, feelings towards and preferences in using technology. Seventy-five patients were recruited. Most patients had computer access (72% and internet (69% at home. Sixty-five percent of participants were willing to participate in telerehabilitation. A significant difference was found between older and younger patients. Watching videos on an electronic device was the preferred method for a technology-based home exercise program and phone call the preferred method of communication.  Results indicate telerehabilitation in the TJR population is feasible from the perspective of access to, feelings toward, and preferences for technology. Keywords: Hip replacement, Knee replacement, Telerehabilitation, Telemedicine, Total joint replacement

  11. Hormone replacement therapy and risk of glioma

    DEFF Research Database (Denmark)

    Andersen, Lene; Friis, Søren; Hallas, Jesper

    2013-01-01

    Aim: Several studies indicate that use of hormone replacement therapy (HRT) is associated with an increased risk of intracranial meningioma, while associations between HRT use and risk of other brain tumors have been less explored. We investigated the influence of HRT use on the risk of glioma...

  12. Antibiotic Dosing in Continuous Renal Replacement Therapy.

    Science.gov (United States)

    Shaw, Alexander R; Mueller, Bruce A

    2017-07-01

    Appropriate antibiotic dosing is critical to improve outcomes in critically ill patients with sepsis. The addition of continuous renal replacement therapy makes achieving appropriate antibiotic dosing more difficult. The lack of continuous renal replacement therapy standardization results in treatment variability between patients and may influence whether appropriate antibiotic exposure is achieved. The aim of this study was to determine if continuous renal replacement therapy effluent flow rate impacts attaining appropriate antibiotic concentrations when conventional continuous renal replacement therapy antibiotic doses were used. This study used Monte Carlo simulations to evaluate the effect of effluent flow rate variance on pharmacodynamic target attainment for cefepime, ceftazidime, levofloxacin, meropenem, piperacillin, and tazobactam. Published demographic and pharmacokinetic parameters for each antibiotic were used to develop a pharmacokinetic model. Monte Carlo simulations of 5000 patients were evaluated for each antibiotic dosing regimen at the extremes of Kidney Disease: Improving Global Outcomes guidelines recommended effluent flow rates (20 and 35 mL/kg/h). The probability of target attainment was calculated using antibiotic-specific pharmacodynamic targets assessed over the first 72 hours of therapy. Most conventional published antibiotic dosing recommendations, except for levofloxacin, reach acceptable probability of target attainment rates when effluent rates of 20 or 35 mL/kg/h are used. Copyright © 2017 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

  13. Joint Replacement (Finger and Wrist Joints)

    Science.gov (United States)

    ... All Topics A-Z Videos Infographics Symptom Picker Anatomy Bones Joints Muscles Nerves Vessels Tendons About Hand Surgery What is a Hand Surgeon? What is a Hand Therapist? Media Find a Hand Surgeon Home Anatomy Joint Replacement Email to a friend * required fields ...

  14. Phase equilibria in the system As2-O5 - SrO

    International Nuclear Information System (INIS)

    Kasenov, B.K.; Ashlyaeva, I.V.

    1993-01-01

    T-x phase state diagram of As 2 O 5 -SrO system was investigated by the methods of physicochemical analysis. It was established that incongruently melting Sr(AsO 3 ) 2 (t mel 900 deg C), Sr 2 As 2 O 4 (t mel = 1140 deg C), Sr 4 As 2 O 9 (t mel = 1390 deg C) and congruently melting at 1635 deg C Sr 3 (AsO 4 ) 2 formed in the system. Eutectic points were revealed in the system: As 2 O 5 -Sr(AsO 3 ) 2 (15.0 mol % SrO, 700 deg C) and Sr 3 (AsO 4 ) 2 -Sr 4 As 2 O 9 (78 mol % SrO, 1370 deg C)

  15. Lecithin intake and serum cholesterol.

    NARCIS (Netherlands)

    Knuiman, J.T.; Beynen, A.C.; Katan, M.B.

    1989-01-01

    To find out whether the consumption of lecithin has a more beneficial effect on serum cholesterol than does the consumption of equivalent amounts of polyunsaturated oils, we scrutinized 24 studies on the effect of supplementary lecithin intakes ranging from 1 to 54 mg/d. Most of the studies lacked

  16. Serum transferrin receptor in polycythemia.

    Science.gov (United States)

    Manteiga, R; Remacha, A F; Sardà, M P; Ubeda, J

    1998-10-01

    We measured serum transferrin receptor (sTfR) levels in 22 patients with polycythemia vera and in 26 cases of secondary polycythemia. In our study, raised sTfR levels in both polycythemia groups were related to iron deficiency.

  17. Serum zinc level in thalassemia

    International Nuclear Information System (INIS)

    Keikhaei, B.; Badavi, M.; Pedram, M.; Zandian, K.

    2010-01-01

    To compare serum zinc level between Thalassemia Major (TM) patients and normal population at Shafa Hospital in South West of Iran. A total of 25 male and 36 female of TM patients were enrolled in this study. Out of 61 patients thirty were treated by deferroxamine (DFO) and 31 were on the combination of DFO and deferiprone (DEF) protocol therapy. Sixty normal subjects of the matching age and gender were recruited as controls. From each patient and control group 2 ml of blood was taken in fasting condition. Cell blood count and serum zinc were carried out for both thalassemia patients and normal subjects. The mean age of patients and control group was 15+- 5 years. Mean serum zinc level was 68.97+- 21.12 mu g/dl, 78.10-28.50 mu g/dl, and 80.16+- 26.54 mu g/dl in the TM with DFO, TM with DFO + DEF combination protocol and control group respectively. There was no significant correlation between patients and control group. However 50 percent of TM with DFO, 38.7 percent of TM with DFO + DEF and 32.8 percent of control group had hypozincemia. Nearly 40 to 50 percent of TM patients and one third of normal subjects are suffering from hypozincemia. This study shows that low level of serum zinc is a health problem in both thalassemia patients and normal population in South West of Iran. (author)

  18. Contrasting pressure effects in Sr2VFeAsO3 and Sr2ScFePO3

    International Nuclear Information System (INIS)

    Kotegawa, Hisashi; Kawazoe, Takayuki; Tou, Hideki; Murata, Keizo; Ogino, Hiraku; Kishio, Kohji; Shimoyama, Jun-ichi

    2009-01-01

    We report the resistivity measurements under pressure of two Fe-based superconductors with a thick perovskite oxide layer, Sr 2 VFeAsO 3 and Sr 2 ScFePO 3 . The superconducting transition temperature T c of Sr 2 VFeAsO 3 markedly increases with increasing pressure. Its onset value, which was T c onset =36.4 K at ambient pressure, increases to T c onset =46.0 K at ∼4 GPa, ensuring the potential of the '21113' system as a high-T c material. However, the superconductivity of Sr 2 ScFePO 3 is strongly suppressed under pressure. The T c onset of ∼16 K decreases to ∼5 K at ∼4 GPa, and the zero-resistance state is almost lost. We discuss the factor that induces this contrasting pressure effect. (author)

  19. Steam generator replacement from ALARA aspects

    International Nuclear Information System (INIS)

    Terry, I.; Breznik, B.

    2003-01-01

    This paper is going to consider radiological related parameters important for steam generator replacement (SGR) implementation. These parameters are identified as ALARA related parameters, owner-contractor relationship, planning, health physics with logistic services, and time required for the replacement. ALARA related parameters such as source or initial dose rate and plant system configuration define the initial conditions for the planning. There is room to optimise work planning. managerial procedures and also the staff during the implementation phase. The overview of these general considerations is based on the following background: using internationally available data and the experience of one of the vendors, i.e. Siemens-Framatome, and management experience of SG replacement which took place at Krsko NPP in the spring of 2000. Generally plant decisions on maintenance or repair procedures under radiation conditions take into account ALARA considerations. But in the main it is difficult to adjudge the results of an ALARA study, usually in the form of a collective dose estimate, because a comparison standard is missing. That is, very often the planned work is of a one-off nature so comparisons are not possible or the scopes are not the same. In such a case the collective doses for other types of work are looked at and a qualitative evaluation is made. In the case of steam generator replacement this is not the case. Over years of steam generator replacements world-wide a standard has been developed gradually. The first part of the following displays an overview of SGR and sets the Krsko SGR in perspective by applying dose analysis. The second part concentrates on the Krsko SGR itself and its ALARA aspects. (authors)

  20. Shape coexistence in neutron-rich Sr isotopes : Coulomb excitation of $^{96}$Sr

    CERN Multimedia

    Clement, E; Siem, S; Czosnyka, T

    2007-01-01

    The nuclei in the mass region A $\\cong$ 100 around Sr and Zr show a dramatic change of the nuclear ground-state shape from near spherical for N $\\leq$ 58 to strongly deformed for N $\\geq$ 60. Theoretical calculations predict the coexistence of slightly oblate and strongly prolate deformed configurations in the transitional region. However, excited rotational structures based on the highly deformed configuration, which becomes the ground state at N = 60, are not firmly established in the lighter isotopes, and the earlier interpretation of a very abrupt change of shape has been challenged by recent experimental results in favor of a rather gradual change. We propose to study the electromagnetic properties of the neutron-rich nucleus $_{38}^{96}$Sr$_{58}$ by low-energy Coulomb excitation using the REX-ISOLDE facility and the MINIBALL detector array. Both transitional and diagonal matrix elements will be extracted, resulting in a complete description of the transition strengths and quadrupole moments of the low-l...