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Sample records for sert density decreased

  1. Ontogeny of SERT Expression and Antidepressant-like Response to Escitalopram in Wild-Type and SERT Mutant Mice.

    Science.gov (United States)

    Mitchell, Nathan C; Gould, Georgianna G; Koek, Wouter; Daws, Lynette C

    2016-08-01

    Depression is a disabling affective disorder for which the majority of patients are not effectively treated. This problem is exacerbated in children and adolescents for whom only two antidepressants are approved, both of which are selective serotonin reuptake inhibitor (SSRIs). Unfortunately SSRIs are often less effective in juveniles than in adults; however, the mechanism(s) underlying age-dependent responses to SSRIs is unknown. To this end, we compared the antidepressant-like response to the SSRI escitalopram using the tail suspension test and saturation binding of [(3)H]citalopram to the serotonin transporter (SERT), the primary target of SSRIs, in juvenile [postnatal day (P)21], adolescent (P28), and adult (P90) wild-type (SERT+/+) mice. In addition, to model individuals carrying low-expressing SERT variants, we studied mice with reduced SERT expression (SERT+/-) or lacking SERT (SERT-/-). Maximal antidepressant-like effects were less in P21 mice relative to P90 mice. This was especially apparent in SERT+/- mice. However, the potency for escitalopram to produce antidepressant-like effects in SERT+/+ and SERT+/- mice was greater in P21 and P28 mice than in adults. SERT expression increased with age in terminal regions and decreased with age in cell body regions. Binding affinity values did not change as a function of age or genotype. As expected, in SERT-/- mice escitalopram produced no behavioral effects, and there was no specific [(3)H]citalopram binding. These data reveal age- and genotype-dependent shifts in the dose-response for escitalopram to produce antidepressant-like effects, which vary with SERT expression, and may contribute to the limited therapeutic response to SSRIs in juveniles and adolescents. Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics.

  2. Neonatal citalopram exposure decreases serotonergic fiber density in the olfactory bulb of male but not female adult rats

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    Junlin eZhang

    2013-05-01

    Full Text Available Manipulation of serotonin (5HT during early development has been shown to induce long-lasting morphological changes within the raphe nuclear complex and serotonergic circuitry throughout the brain. Recent studies have demonstrated altered raphe-derived 5HT transporter (SERT immunoreactive axonal expression in several cortical target sites after brief perinatal exposure to selective 5HT reuptake inhibitors such as citalopram (CTM. Since the serotonergic raphe nuclear complex projects to the olfactory bulb (OB and perinatal 5HT disruption has been shown to disrupt olfactory behaviors, the goal of this study was to further investigate such developmental effects in the OB of CTM exposed animals. Male and female rat pups were exposed to CTM from postnatal day 8-21. After animals reach adulthood (>90 days, OB tissue sections were processed immunohistochemically for SERT antiserum. Our data revealed that the density of the SERT immunoreactive fibers decreased ~40% in the OB of CTM exposed male rats, but not female rats. Our findings support a broad and long-lasting change throughout most of the 5HT system, including the OB, after early manipulation of 5HT. Because dysfunction of the early 5HT system has been implicated in the etiology of neurodevelopmental disorders such as autism spectrum disorders (ASDs, these new findings may offer insight into the abnormal olfactory perception often noted in patients with ASD.

  3. Mechanisms of Intestinal Serotonin Transporter (SERT Upregulation by TGF-β1 Induced Non-Smad Pathways.

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    Saad Nazir

    Full Text Available TGF-β1 is an important multifunctional cytokine with numerous protective effects on intestinal mucosa. The influence of TGF-β1 on serotonin transporter (SERT activity, the critical mechanism regulating the extracellular availability of serotonin (5-HT, is not known. Current studies were designed to examine acute effects of TGF-β1 on SERT. Model human intestinal Caco-2 cells grown as monolayer's or as cysts in 3D culture and ex vivo mouse model were utilized. Treatment of Caco-2 cells with TGF-β1 (10 ng/ml, 60 min stimulated SERT activity (~2 fold, P<0.005. This stimulation of SERT function was dependent upon activation of TGF-β1 receptor (TGFRI as SB-431542, a specific TGF-βRI inhibitor blocked the SERT stimulation. SERT activation in response to TGF-β1 was attenuated by inhibition of PI3K and occurred via enhanced recruitment of SERT-GFP to apical surface in a PI3K dependent manner. The exocytosis inhibitor brefeldin A (2.5 μM attenuated the TGF-β1-mediated increase in SERT function. TGF-β1 increased the association of SERT with the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE syntaxin 3 (STX3 and promoted exocytosis of SERT. Caco-2 cells grown as cysts in 3D culture recapitulated the effects of TGF-β1 showing increased luminal staining of SERT. Ussing chamber studies revealed increase in 3H-5-HT uptake in mouse ileum treated ex vivo with TGF-β1 (10 ng/ml, 1h. These data demonstrate a novel mechanism rapidly regulating intestinal SERT via PI3K and STX3. Since decreased SERT is implicated in various gastro-intestinal disorders e.g IBD, IBS and diarrhea, understanding mechanisms stimulating SERT function by TGF-β1 offers a novel therapeutic strategy to treat GI disorders.

  4. The Influence of Decreased Levels of High Density Lipoprotein ...

    African Journals Online (AJOL)

    Background: Changes in lipoproteins levels in sickle cell disease (SCD) patients are well.known, but the physiological ramifications of the low levels observed have not been entirely resolved. Aim: The aim of this study is to evaluate the impact of decreased levels of high density lipoprotein cholesterol (HDL.c) on ...

  5. Vacuum heating evaluation for plasmas of exponentially decreasing density profile

    International Nuclear Information System (INIS)

    Pestehe, S.J.; Mohammadnejad, M.

    2008-01-01

    Ultra-short pulse lasers have opened a regime of laser-plasma interaction where plasmas have scale lengths shorter than the laser wavelength and allow the possibility of generating near-solid density plasmas. The interaction of high-intensity laser beams with sharply bounded high-density and small scale length plasmas is considered. Absorption of the laser energy associated with the mechanism of dragging electrons out of the plasma into the vacuum and sending them back into the plasma with the electric field component along the density gradient, so called vacuum heating, is studied. An exponentially decreasing electron density profile is assumed. The vector potential of the electromagnetic field propagating through the plasma is calculated and the behaviour of the electric and magnetic components of the electromagnetic field is studied. The fraction of laser power absorbed in this process is calculated and plotted versus the laser beam incidence angle, illumination energy, and the plasma scale length

  6. Evaluation of brain SERT occupancy by resveratrol against MDMA-induced neurobiological and behavioral changes in rats: A 4-[¹⁸F]-ADAM/small-animal PET study.

    Science.gov (United States)

    Shih, Jui-Hu; Ma, Kuo-Hsing; Chen, Chien-Fu F; Cheng, Cheng-Yi; Pao, Li-Heng; Weng, Shao-Ju; Huang, Yuahn-Sieh; Shiue, Chyng-Yann; Yeh, Ming-Kung; Li, I-Hsun

    2016-01-01

    The misuse of 3,4-methylenedioxymethamphetamine (MDMA) has drawn a growing concern worldwide for its psychophysiological impacts on humans. MDMA abusers are often accompanied by long-term serotonergic neurotoxicity, which is associated with reduced density of cerebral serotonin transporters (SERT) and depressive disorders. Resveratrol (RSV) is a natural polyphenolic phytoalexin that has been known for its antidepressant and neuroprotective effects. However, biological targets of RSV as well as its neuroprotective effects against MDMA remained largely unknown. In this study, we examined binding potency of RSV and MDMA to SERT using small-animal positron emission tomography (PET) with the SERT radioligand, N,N-dimethyl-2-(2-amino-4-[(18)F]fluorophenylthio)benzylamine (4-[(18)F]-ADAM) and investigated the protection of RSV against the acute and long-term adverse effects of MDMA. We found that RSV exhibit binding potentials to SERT in vivo in a dose-dependent manner with variation among brain regions. When the MDMA-treated rats (10mg/kg, s.c.) were co-injected with RSV (20mg/kg, i.p.) twice daily for 4 consecutive days, MDMA-induced acute elevation in plasma corticosterone was significantly reduced. Further, 4-[(18)F]-ADAM PET imaging revealed that RSV protected against the MDMA-induced decrease in SERT availability in the midbrain and the thalamus 2 weeks following the co-treatment. The PET data were comparable to the observation from the forced swim test that RSV sufficiently ameliorated the depressive-like behaviors of the MDMA-treated rats. Together, these findings suggest that RSV is a potential antidepressant and may confer protection against neurobiological and behavioral changes induced by MDMA. Copyright © 2015 Elsevier B.V. and ECNP. All rights reserved.

  7. The Influence of Decreased Levels of High Density Lipoprotein ...

    African Journals Online (AJOL)

    very low density lipoprotein cholesterol, and triglyceride were assayed. ... Abiodun and Gwarzo: Association of high density lipoprotein cholesterol with haemolysis in sickle cell disease ... analyses were carried out to determine the correlation.

  8. Nonuniform Internal Structure of Fibrin Fibers: Protein Density and Bond Density Strongly Decrease with Increasing Diameter

    Directory of Open Access Journals (Sweden)

    Wei Li

    2017-01-01

    Full Text Available The major structural component of a blood clot is a meshwork of fibrin fibers. It has long been thought that the internal structure of fibrin fibers is homogeneous; that is, the protein density and the bond density between protofibrils are uniform and do not depend on fiber diameter. We performed experiments to investigate the internal structure of fibrin fibers. We formed fibrin fibers with fluorescently labeled fibrinogen and determined the light intensity of a fiber, I, as a function of fiber diameter, D. The intensity and, thus, the total number of fibrin molecules in a cross-section scaled as D1.4. This means that the protein density (fibrin per cross-sectional area, ρp, is not homogeneous but instead strongly decreases with fiber diameter as D-0.6. Thinner fibers are denser than thicker fibers. We also determined Young’s modulus, Y, as a function of fiber diameter. Y decreased strongly with increasing D; Y scaled as D-1.5. This implies that the bond density, ρb, also scales as D-1.5. Thinner fibers are stiffer than thicker fibers. Our data suggest that fibrin fibers have a dense, well-connected core and a sparse, loosely connected periphery. In contrast, electrospun fibrinogen fibers, used as a control, have a homogeneous cross-section.

  9. Brain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitution

    Directory of Open Access Journals (Sweden)

    José Jaime Herrera-Pérez

    2013-01-01

    Full Text Available In preclinical and clinical studies aging has been associated with a deteriorated response to antidepressant treatment. We hypothesize that such impairment is explained by an age-related decrease in brain serotonin transporter (SERT expression associated with low testosterone (T levels. The objectives of this study were to establish (1 if brain SERT expression is reduced by aging and (2 if the SERT expression in middle-aged rats is increased by T-restitution. Intact young rats (3–5 months and gonad-intact middle-aged rats with or without T-restitution were used. The identification of the brain SERT expression was done by immunofluorescence in prefrontal cortex, lateral septum, hippocampus, and raphe nuclei. An age-dependent reduction of SERT expression was observed in all brain regions examined, while T-restitution recovered the SERT expression only in the dorsal raphe of middle-aged rats. This last action seems relevant since dorsal raphe plays an important role in the antidepressant action of selective serotonin reuptake inhibitors. All data suggest that this mechanism accounts for the T-replacement usefulness to improve the response to antidepressants in the aged population.

  10. Mechanical design of SERT 2 thruster system

    Science.gov (United States)

    Zavesky, R. J.; Hurst, E. B.

    1972-01-01

    The mechanical design of the mercury bombardment thruster that was tested on SERT is described. The report shows how the structural, thermal, electrical, material compatibility, and neutral mercury coating considerations affected the design and integration of the subsystems and components. The SERT 2 spacecraft with two thrusters was launched on February 3, 1970. One thruster operated for 3782 hours and the other for 2011 hours. A high voltage short resulting from buildup of loose eroded material was believed to be the cause of failure.

  11. SERT Transformation Study. Technical Report No. 70.

    Science.gov (United States)

    Day, Richard; And Others

    This research report deals with the transformations of stimulus sentences that primary grade speakers of Hawaii Creole English (HCE) made when they were asked to repeat sentences said to them in Standard English. The test used was the Kamehameha Early Education Program (KEEP) Standard English Repetition Test (SERT) which was administered to the 21…

  12. A ontologia discursiva de Os sertões The discursive ontology of Os sertões

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    Leopoldo M. Bernucci

    1998-07-01

    Full Text Available Este artigo discute atributos de Os sertões, analisando sua ontologia discursiva, em particular os aspectos ligados às narrativas imaginárias e literárias. Mostra que a principal obra de Euclides conjuga pelo menos dois modos discursivos: o das ciências e um outro que caracteriza as narrativas sobre realidades imaginárias e literárias. Trechos são destacados com o objetivo de demonstrar que na sua construção híbrida participam elementos que poderiam pertencer tanto à ficção como à historiografia. Apoiando-se em Hayden White, o autor contempla três modos interpretativos da história de Canudos em Os sertões: o argumentativo, o explicativo e o ideológico. Finalmente, realiza breve comparação com A guerra do fim do mundo, de Vargas Llosa, quanto ao modo e a seqüência como são narrados os fatos.This analysis of the discursive ontology of Os sertões is particularly concerned with the book’s imaginary and literary narratives. Cunha’s main work combines at least two discursive styles: the discourse of the sciences and the discourse that characterizes narratives dealing with imaginary and literary realities. Selected excerpts show how the hybrid construction of Os sertões relies on elements which may belong to the realm of either fiction or historiography. Based on the ideas of Hayden White, the article detects three ways in which Os sertões interprets the history of Canudos: argumentative, explanatory, and ideological. The text ends with a brief comparison of the narration and sequencing of facts in Vargas Llosa’s La guerra del fin del mundo and Cunha’s Os sertões.

  13. Space Solar Power Exploratory Research and Technology (SERT) Technical Interchange Meeting 2 (SERT TIM 2)

    Science.gov (United States)

    Howell, Joe; Sanders, Clark W.

    2000-01-01

    The University of Alabama in Huntsville's (UAH) Propulsion Research Center hosted the Space Solar Power Exploratory Research & Technology (SERT) Technical Interchange Meeting TIM) 2 in Huntsville, Alabama December 7-10. 1999 with 126 people in attendance. The SERT program includes both competitively procured activities. which are being implemented through a portfolio of focused R&D investments--with the maximum leveraging of existing resources inside and outside NASA. and guided by these system studies. Axel Roth. Director of the Flight Projects Directorate NASA MSFC, welcomed the SERT TIM 2 participants and challenged them to develop the necessary technologies and demonstrations that will lead to Space Solar Power (SSP) International implementation. Joe Howell, NASA MSFC, reiterated the SERT TIM 2 objectives: 1) Refining and modeling systems approaches for the utilization of SSP concepts and technologies, ranging, from the near-term e.g. for space science, exploration and commercial space applications to the far-term (e. g. SSP for terrestrial markets), including systems concepts, technology, infrastructure (i.g., transportation), and economics. 2) Conducting technology research, development and demonstration activities to produce "proof- of-concept" validation of critical SSP elements for both the nearer and farther-term applications. 3) Initiating partnerships Nationality and Internationally that could be expanded, as appropriate, to pursue later SSP technology and applications (e.g., space science. colonization, etc.). Day one began with the NASA Centers presenting their SERT activities summary since SERT TIM 1 and wound up with a presentation by Masahiro Mori, NASDA titled "NASDA In-house Study for SSP". Demonstration for the Near-Term. Day two began with the SERT Systems Studies and Analysis reports resulting from NRA 8-23 followed by presentations of SERT Technology Demonstrations reports resulting from NRA 8-23. Day two closed with John Mankins presentation

  14. High follicle density does not decrease sweat gland density in Huacaya alpacas.

    Science.gov (United States)

    Moore, K E; Maloney, S K; Blache, D

    2015-01-01

    When exposed to high ambient temperatures, mammals lose heat evaporatively by either sweating from glands in the skin or by respiratory panting. Like other camelids, alpacas are thought to evaporate more water by sweating than panting, despite a thick fleece, unlike sheep which mostly pant in response to heat stress. Alpacas were brought to Australia to develop an alternative fibre industry to sheep wool. In Australia, alpacas can be exposed to ambient temperatures higher than in their native South America. As a young industry there is a great deal of variation in the quality and quantity of the fleece produced in the national flock. There is selection pressure towards animals with finer and denser fleeces. Because the fibre from secondary follicles is finer than that from primary follicles, selecting for finer fibres might alter the ratio of primary and secondary follicles. In turn the selection might alter sweat gland density because the sweat glands are associated with the primary follicle. Skin biopsy and fibre samples were obtained from the mid-section of 33 Huacaya alpacas and the skin sections were processed into horizontal sections at the sebaceous gland level. Total, primary, and secondary follicles and the number of sweat gland ducts were quantified. Fibre samples from each alpaca were further analysed for mean fibre diameter. The finer-fibred animals had a higher total follicle density (Palpacas with high follicle density should not be limited for potential sweating ability. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. Host density increases parasite recruitment but decreases host risk in a snail-trematode system.

    Science.gov (United States)

    Buck, J C; Hechinger, R F; Wood, A C; Stewart, T E; Kuris, A M; Lafferty, K D

    2017-08-01

    Most species aggregate in local patches. High host density in patches increases contact rate between hosts and parasites, increasing parasite transmission success. At the same time, for environmentally transmitted parasites, high host density can decrease infection risk to individual hosts, because infective stages are divided among all hosts in a patch, leading to safety in numbers. We tested these predictions using the California horn snail, Cerithideopsis californica (=Cerithidea californica), which is the first intermediate host for at least 19 digenean trematode species in California estuaries. Snails become infected by ingesting trematode eggs or through penetration by free-swimming miracidia that hatch from trematode eggs deposited with final-host (bird or mammal) feces. This complex life cycle decouples infective-stage production from transmission, raising the possibility of an inverse relationship between host density and infection risk at local scales. In a field survey, higher snail density was associated with increased trematode (infected snail) density, but decreased trematode prevalence, consistent with either safety in numbers, parasitic castration, or both. To determine the extent to which safety in numbers drove the negative snail-density-trematode-prevalence association, we manipulated uninfected snail density in 83 cages at eight sites within Carpinteria Salt Marsh (California, USA). At each site, we quantified snail density and used data on final-host (bird and raccoon) distributions to control for between-site variation in infective-stage supply. After three months, overall trematode infections per cage increased with snail biomass density. For egg-transmitted trematodes, per-snail infection risk decreased with snail biomass density in the cage and surrounding area, whereas per-snail infection risk did not decrease for miracidium-transmitted trematodes. Furthermore, both trematode recruitment and infection risk increased with infective

  16. The influence of plasma density decreasement by pre-pulse on the laser wakefield acceleration

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    Ke-Gong Dong

    2011-12-01

    Full Text Available In the laser wakefield acceleration, the generation of electron beam is very sensitive to the plasma density. Not only the laser-wakefield interaction, but also the electron trapping and acceleration would be effected by the plasma density. However, the plasma density could be changed in the experiment by different reasons, which will result in the mismatch of parameters arranged initially. Forward Raman scattering spectrum demonstrated that the interaction density was decreased obviously in the experiment, which was verified by the pre-pulse conditions and two-dimensional particle-in-cell simulations. It was demonstrated that the plasma density was very important on the self-evolutions and energy coupling of laser pulse and wakefield, and eventually the energy spectrum of electron beam.

  17. Electron density profiles in the background of LF absorption during Forbush-decrease and PSE

    International Nuclear Information System (INIS)

    Satori, G.

    1989-01-01

    Based on the simulation of different Forbush decrease and particle precipitation effects in the D region, electron density profiles in the mid-latitudes the ionospheric absorption of low frequency (LF) radio waves was determined. The absorption variations at different frequenceis are strongly affected by the shape of the electron density profile. A structure appears which sometimes resembles the letter S (in a sloping form). Both the height (around 70 to 72 km) and the depth of the local minimum in the electron density contribute to the computed absorption changes of various degree at different frequencies. In this way several observed special absorption events can be interpreted

  18. Serotonin transporter (SERT and translocator protein (TSPO expression in the obese ob/ob mouse

    Directory of Open Access Journals (Sweden)

    Santini Ferruccio

    2011-02-01

    Full Text Available Abstract Background An ever growing body of evidences is emerging concerning metabolism hormones, neurotransmitters or stress-related biomarkers as effective modulators of eating behavior and body weight in mammals. The present study sought at examining the density and affinity of two proteins related to neurotransmission and cell metabolism, the serotonin transporter SERT and the cholesterol import-benzodiazepine site TSPO (translocator protein, in a rodent leptin-lacking mutant, the obese ob/ob mouse. Binding studies were thus carried out in brain or peripheral tissues, blood platelets (SERT and kidneys (TSPO, of ob/ob and WT mice supplied with a standard diet, using the selective radiochemical ligands [3H]-paroxetine and [3H]-PK11195. Results We observed comparable SERT number or affinity in brain and platelets of ob/ob and WT mice, whilst a significantly higher [3H]-PK11195 density was reported in the brain of ob/ob animals. TSPO binding parameters were similar in the kidneys of all tested mice. By [3H]-PK11195 autoradiography of coronal hypothalamic-hippocampal sections, an increased TSPO signal was detected in the dentate gyrus (hippocampus and choroids plexus of ob/ob mice, without appreciable changes in the cortex or hypothalamic-thalamic regions. Conclusions These findings show that TSPO expression is up-regulated in cerebral regions of ob/ob leptin-deficient mice, suggesting a role of the translocator protein in leptin-dependent CNS trophism and metabolism. Unchanged SERT in mutant mice is discussed herein in the context of previous literature as the forerunner to a deeper biochemical investigation.

  19. Functional Capillary Density Decreases after the First Week of Life in Term Neonates

    NARCIS (Netherlands)

    Top, A. P. C.; van Dijk, M.; van Velzen, J. E.; Ince, C.; Tibboel, D.

    2010-01-01

    Background: Changes in the microcirculation have been recognized to play a crucial role in many disease processes. In premature neonates, functional capillary density (FCD) decreases during the first months of life. Objectives: The aims of this study were to obtain microcirculatory parameters in

  20. Functional capillary density decreases after the first week of life in term neonates

    NARCIS (Netherlands)

    A.P.C. Top (Anke); M. van Dijk (Monique); J.E. van Velzen; C. Ince (Can); D. Tibboel (Dick)

    2010-01-01

    textabstractBackground: Changes in the microcirculation have been recognized to play a crucial role in many disease processes. In premature neonates, functional capillary density (FCD) decreases during the first months of life. Objectives: The aims of this study were to obtain microcirculatory

  1. [Sertürner and morphine--a historical vignette].

    Science.gov (United States)

    Jurna, I

    2003-08-01

    Friedrich Wilhelm Sertürner was born near Paderborn in 1783. At the age of twenty he passed examinations as a pharmacist's assistant in Paderborn. In a letter to the editor of Trommsdorffs Journal der Pharmacie Vol 13 (1805) he reported on the isolation of a substance from opium which showed alkaline character and was later called by him "morphine". In 1806, Sertürner moved to Einbeck where he first worked as assistant to the tenant of the magistrate's pharmacy. In 1809, he became pharmacist and, since the tenant was already 75 years old, he intended to take charge of the pharmacy. However,he was not successful. During the invasion of Napoleon Bonaparte's troops into Europe, French legislation became valid in those parts which fell under French government. According to French law, Sertürner was allowed to open a second pharmacy. In Einbeck, Sertürner continued research work on morphine and published the results in two papers. In one of these (1817), he introduced observations made with the drug in humans and for the first time called it "morphine". The French chemist Gay-Lussac showed interest in that publication and ordered a translation into French which earned Sertürner the scientific break-through. His was the first achievement in alkaloid research, and for that he received a doctor degree from the university of Jena in 1817.When Napoleon was finally defeated, Sertürner had to close his pharmacy in Einbeck and found another one in Hameln. When asiatic cholera spread in Germany in 1831, he postulated that cholera is caused by a poisonous,animated reproducing organism and made suggestions to avoid infection which are still valid today.Sertürner was honoured by many institutions but still felt not properly esteemed. His behavior become odd and he debilitated. He died in 1841 and was buried in Einbeck.

  2. Density increment and decreased survival of rat red blood cells induced by cadmium

    International Nuclear Information System (INIS)

    Kunimoto, M.; Miura, T.

    1986-01-01

    Male Wistar rats were injected with CdCl 2 subcutaneously to examine in vivo effects of Cd on density and survival of red blood cells. During the 7 days after administration of 1.0 mg Cd/kg, the following sequence of events occurred: (1) a progressive increase in the amount of more dense red blood cells concomitant with a decrease in that of light red blood cells from the first to the third day; (2) an increase in the spleen weight at the third day; (3) a decrease in the hematocrit value and an increase in the amount of light red blood cells at the fifth day; and (4) a recovery of the hematocrit value at the seventh day. Five days after administration, the hematocrit value decreased in a dose-dependent mode and the decrease was significant at the 1% level at 1.0 and 1.5 mg Cd/kg. A highly significant splenomegaly was also observed at 0.5 to 1.5 mg Cd/kg. In order to label red blood cells in vivo, [ 3 H] diisopropylfluorophosphate ([ 3 H]DFP) was injected into rats. At Day 11, Cd at either 0.5 or 1.0 mg/kg was administered to [ 3 H]DFP-prelabeled animals. Cd administration accelerated 3 H-labeled red cell clearance from the blood. Six days after Cd administration, the radioactivity of red blood cells was 76 and 68% of the control at 0.5 and 1.0 mg Cd/kg, respectively. In vitro treatment of rat red density and accelerated in vivo clearance of red blood cells from the recipient circulation. These results show that Cd at low dose can cause anemia by increasing red cell density and by accelerating red cell sequestration, presumably in the spleen

  3. Neuron density is decreased in the prefrontal cortex in Williams syndrome.

    Science.gov (United States)

    Lew, Caroline Horton; Brown, Chelsea; Bellugi, Ursula; Semendeferi, Katerina

    2017-01-01

    Williams Syndrome (WS) is a rare neurodevelopmental disorder associated with a hemideletion in chromosome 7, which manifests a distinct behavioral phenotype characterized by a hyperaffiliative social drive, in striking contrast to the social avoidance behaviors that are common in Autism Spectrum Disorder (ASD). MRI studies have observed structural and functional abnormalities in WS cortex, including the prefrontal cortex (PFC), a region implicated in social cognition. This study utilizes the Bellugi Williams Syndrome Brain Collection, a unique resource that comprises the largest WS postmortem brain collection in existence, and is the first to quantitatively examine WS PFC cytoarchitecture. We measured neuron density in layers II/III and V/VI of five cortical areas: PFC areas BA 10 and BA 11, primary motor BA 4, primary somatosensory BA 3, and visual area BA 18 in six matched pairs of WS and typically developing (TD) controls. Neuron density in PFC was lower in WS relative to TD, with layers V/VI demonstrating the largest decrease in density, reaching statistical significance in BA 10. In contrast, BA 3 and BA 18 demonstrated a higher density in WS compared to TD, although this difference was not statistically significant. Neuron density in BA 4 was similar in WS and TD. While other cortical areas were altered in WS, prefrontal areas appeared to be most affected. Neuron density is also altered in the PFC of individuals with ASD. Together these findings suggest that the PFC is targeted in neurodevelopmental disorders associated with sociobehavioral alterations. Autism Res 2017, 10: 99-112. © 2016 International Society for Autism Research, Wiley Periodicals, Inc. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

  4. Parietal Fast Sleep Spindle Density Decrease in Alzheimer's Disease and Amnesic Mild Cognitive Impairment

    Science.gov (United States)

    Gorgoni, Maurizio; Lauri, Giulia; Truglia, Ilaria; Cordone, Susanna; Sarasso, Simone; Scarpelli, Serena; Mangiaruga, Anastasia; D'Atri, Aurora; Tempesta, Daniela; Ferrara, Michele; Marra, Camillo; Rossini, Paolo Maria; De Gennaro, Luigi

    2016-01-01

    Several studies have identified two types of sleep spindles: fast (13–15 Hz) centroparietal and slow (11–13 Hz) frontal spindles. Alterations in spindle activity have been observed in Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). Only few studies have separately assessed fast and slow spindles in these patients showing a reduction of fast spindle count, but the possible local specificity of this phenomenon and its relation to cognitive decline severity are not clear. Moreover, fast and slow spindle density have never been assessed in AD/MCI. We have assessed fast and slow spindles in 15 AD patients, 15 amnesic MCI patients, and 15 healthy elderly controls (HC). Participants underwent baseline polysomnographic recording (19 cortical derivations). Spindles during nonrapid eye movements sleep were automatically detected, and spindle densities of the three groups were compared in the derivations where fast and slow spindles exhibited their maximum expression (parietal and frontal, resp.). AD and MCI patients showed a significant parietal fast spindle density decrease, positively correlated with Minimental State Examination scores. Our results suggest that AD-related changes in spindle density are specific for frequency and location, are related to cognitive decline severity, and may have an early onset in the pathology development. PMID:27066274

  5. Inhibition of fatty acid synthesis decreases very low density lipoprotein secretion in the hamster.

    Science.gov (United States)

    Arbeeny, C M; Meyers, D S; Bergquist, K E; Gregg, R E

    1992-06-01

    The hamster was developed as a model to study very low density lipoprotein (VLDL) metabolism, since, as is the case in humans, the hamster liver was found to synthesize apoB-100 and not apoB-48. The effect of inhibiting fatty acid synthesis on the hepatic secretion of VLDL triglyceride (TG) and apolipoprotein (apo) B-100 in this model was then investigated. In an in vivo study, hamsters were fed a chow diet containing 0.15% TOFA (5-tetradecyloxy-2-furancarboxylic acid), an inhibitor of acetyl-CoA carboxylase. After 6 days of treatment, plasma triglyceride and cholesterol levels were decreased by 30.2% and 11.6%, respectively. When the secretion of VLDL-TG by the liver was measured in vivo after injection of Triton WR 1339, TOFA treatment was found to decrease VLDL-TG secretion by 40%. In subsequent in vitro studies utilizing cultured primary hamster hepatocytes, incubation with 20 microM TOFA for 4 h resulted in 98% and 76% inhibition in fatty acid and triglyceride synthesis, respectively; VLDL-TG secretion was decreased by 90%. When hepatocytes were pulsed with [3H]leucine, incubation with TOFA resulted in a 50% decrease in the incorporation of radiolabel into secreted VLDL apoB-100. The results of this study indicate that inhibition of intracellular triglyceride synthesis decreases the secretion of VLDL-TG and apoB-100, and does not result in the secretion of a dense, triglyceride-depleted lipoprotein.

  6. Exposure to long wavelength ultraviolet radiation decreases processing of low density lipoprotein by cultured human fibroblasts

    International Nuclear Information System (INIS)

    Djavaheri-Mergny, M.; Santus, R.; Mora, L.; Maziere, J.C.; Faculte de Medecine Saint-Antoine, 75 -Paris; Maziere, C.; Auclair, M.; Dubertret, L.

    1993-01-01

    Exposure of MRC5 human fibroblasts to UVA radiation (365 nm) resulted in a dose-dependent decrease in low density lipoprotein (LDL) uptake and degradation by cells. Following a 25 J/cm 2 irradiation dose, about 45% and 70% reduction in 125 I-LDL uptake and degradation were observed, respectively. Under the same conditions, the 14 C-sucrose uptake was also decreased to about the same extent as LDL uptake. Cell pretreatment with the antioxidants vitamin E and vitamin C did not prevent the UVA-induced fall in LDL degradation. These results point to the possible effects of UVA radiation on receptor-mediated and nonspecific uptake of exogenous molecules. With special regard to the alterations in receptor-mediated processing of exogenous ligands, such a phenomenon could be of importance in UVA-induced skin degenerative processes. (Author)

  7. Decreased trabecular bone biomechanical competence, apparent density, IGF-II and IGFBP-5 content in acromegaly

    DEFF Research Database (Denmark)

    Ueland, Thor; Ebbesen, Ebbe Nils; Thomsen, Jesper Skovhus

    2002-01-01

    of these growth factors in relation to biomechanical properties in acromegaly. MATERIALS AND METHODS: Trabecular bone biomechanical competence (compression test), apparent density (peripheral quantitative computed tomography, pQCT), and bone matrix contents of calcium (HCl hydrolysis) and IGFs (guanidinium......-HCl extraction) were measured in iliac crest biopsies from 13 patients with active acromegaly (two women and 11 men, aged 21-61 years) and 21 age- and sex-matched controls (four women and 17 men, aged 23-64 years). RESULTS: Trabecular bone pQCT was reduced in acromegalic patients compared with controls (P = 0...... bone content of IGF-I, IGFBP-3, or osteocalcin. However, IGF-II and IGFBP-5 content was decreased (P acromegaly, supporting previous observations...

  8. Decreased bone mineral density in experimental myasthenia gravis in C57BL/6 mice.

    Science.gov (United States)

    Oshima, Minako; Iida-Klein, Akiko; Maruta, Takahiro; Deitiker, Philip R; Atassi, M Zouhair

    2017-09-01

    Experimental autoimmune myasthenia gravis (EAMG), an animal model of myasthenia gravis (MG), can be induced in C57BL/6 (B6, H-2  b ) mice by 2-3 injections with Torpedo californica AChR (tAChR) in complete Freund's adjuvant. Some EAMG mice exhibit weight loss with muscle weakness. The loss in body weight, which is closely associated with bone structure, is particularly evident in EAMG mice with severe muscle weakness. However, the relationship between muscle weakness and bone loss in EAMG has not been studied before. Recent investigations on bone have shed light on association of bone health and immunological states. It is possible that muscle weakness in EAMG developed by anti-tAChR immune responses might accompany bone loss. We determined whether reduced muscle strength associates with decreased bone mineral density (BMD) in EAMG mice. EAMG was induced by two injections at 4-week interval of tAChR and adjuvants in two different age groups. The first tAChR injection was either at age 8 weeks or at 15 weeks. We measured BMD at three skeletal sites, including femur, tibia, and lumbar vertebrae, using dual energy X-ray absorptiometry. Among these bone areas, femur of EAMG mice in both age groups showed a significant decrease in BMD compared to control adjuvant-injected and to non-immunized mice. Reduction in BMD in induced EAMG at a later-age appears to parallel the severity of the disease. The results indicate that anti-tAChR autoimmune response alone can reduce bone density in EAMG mice. BMD reduction was also observed in adjuvant-injected mice in comparison to normal un-injected mice, suggesting that BMD decrease can occur even when muscle activity is normal. Decreased BMD observed in both tAChR-injected and adjuvant-injected mice groups were discussed in relation to innate immunity and bone-related immunology involving activated T cells and tumour necrosis factor-related cytokines that trigger osteoclastogenesis and bone loss.

  9. Charge Energy Transport in Hopping Systems with Rapidly Decreasing Density of States

    Science.gov (United States)

    Mendels, Dan; Organic Electronics Group Technion Team

    2014-03-01

    An accurate description of the carrier hopping topology in the energy domain of hopping systems incorporating a rapidly decreasing density of states and the subsequent energetic position of these systems' so called effective conduction band is crucial for rationalizing and quantifying these systems' thermo-electric properties, doping related phenomena and carrier gradient effects such as the emergence of the General Einstein Relation under degenerate conditions. Additionally, as will be shown, the 'mobile' carriers propagating through the system can have excess energies reaching 0.3eV above the system quasi-Fermi energy. Hence, since these mobile carriers are most prone to reach systems interfaces and interact with oppositely charged carriers, their excess energy should be considered in determining the efficiencies of energy dependent processes such as carrier recombination and exciton dissociation. In light of the stated motivations, a comprehensive numerical and analytical study of the topology of hopping in the energetic density of such systems (i.e. the statistics regarding which energy values carriers visit most and in what manner) was implemented and the main statistical features of the hopping process that determine the position in energy of the system's effective conduction band were distilled. The obtained results also help shed light on yet to be elucidated discrepancies between predictions given by the widely employed transport energy concept and Monte Carlo simulations.

  10. Serotonin transporter (SERT gene polymorphism in Parkinson’s disease

    Directory of Open Access Journals (Sweden)

    Mahmut Özkaya

    2004-06-01

    Full Text Available Background: Parkinson disease (PD is the second most common neurodegenerative disorder with a prevalence of about 2% in persons older than 65 years of age. Neurodegenerative process in PD is not restricted to the dopaminergic neurons of the substantia nigra but also affects serotoninergic neurons. It has been shown that PD brains with Lewy bodies in the substantia nigra also had Lewy bodies in the raphe nuclei. The re-uptake of 5HT released into the synaptic cleft is mediated by the 5HT transporter (SERT. The SERT gene has been mapped to the chromosome of 17q11.1-q12 and has two main polymorphisms: intron two VNTR polymorphism and promoter region 44 bp insertion/deletion polymorphism. Objective: In this study we investigated whether two polymorphic regions in the serotonin transporter gene are associated with PD. Material and Method: After obtaining informed consent, blood samples were collected from 76 patients and 54 healthy volunteers. Genomic DNA was extracted from peripheral leucocytes using standard methods. The SERT gene genotypes were determined using polymerase chain reaction (PCR method. Results: Based on the intron 2 VNTR polymorphism of SERT gene, the distribution of 12/12, 12/10 and 10/10 genotypes were found as, 56.6 %, 35.5 %, 7.9 % in patients whereas this genotype distribution in control group was 40.7 %, 46.3 % and 13 %, respectively. According to 5-HTTLPR polymorphism, the distribution of L/L, L/S and S/S genotypes were found as 27.6 % 51.3 % and 21.1 % in patients whereas this genotype distribution in control group was 33.4 %, 50.0 % and 16.6 %, respectively. Despite the fact that the genotype distribution of SERT gene polymorphism in patients and control group seemed to be different from each other, this difference was not found to be statistically significant. Conclusion: This finding suggests that polymorphisms within the SERT gene do not play a major role in PD susceptibility in the Turkish population.

  11. Prenatal hypoxia induces increased cardiac contractility on a background of decreased capillary density

    Directory of Open Access Journals (Sweden)

    Ousley Victoria

    2009-01-01

    Full Text Available Abstract Background Chronic hypoxia in utero (CHU is one of the most common insults to fetal development and may be associated with poor cardiac recovery from ischaemia-reperfusion injury, yet the effects on normal cardiac mechanical performance are poorly understood. Methods Pregnant female wistar rats were exposed to hypoxia (12% oxygen, balance nitrogen for days 10–20 of pregnancy. Pups were born into normal room air and weaned normally. At 10 weeks of age, hearts were excised under anaesthesia and underwent retrograde 'Langendorff' perfusion. Mechanical performance was measured at constant filling pressure (100 cm H2O with intraventricular balloon. Left ventricular free wall was dissected away and capillary density estimated following alkaline phosphatase staining. Expression of SERCA2a and Nitric Oxide Synthases (NOS proteins were estimated by immunoblotting. Results CHU significantly increased body mass (P in utero. Conclusion These data offer potential mechanisms for poor recovery following ischaemia, including decreased coronary flow reserve and impaired angiogenesis with subsequent detrimental effects of post-natal cardiac performance.

  12. Os Sertões: un retrato de la locura colectiva

    Directory of Open Access Journals (Sweden)

    Juan Manuel Fernández

    2013-12-01

    Full Text Available En torno a Os Sertões (1902, podemos explorar una sensibilidad sobre un resto social, la comunidad de Canudos, que está signada principalmente por una criminalización y patologización que abreva en teorías psiquiátricas contemporáneas. La disposición de diversos fragmentos de este ensayo interpretativo junto a los de otros textos de la teoría psiquiátrica o de la literatura nos permitirán sondear la particularidad de las lecturas de Euclides da Cunha sobre la modernidad y su resto, sobre el crimen y la locura entre el sertón y el litoral brasileño, así como también rastrear el devenir de esta sensibilidad más allá del acontecimiento.

  13. Normal Parathyroid Function with Decreased Bone Mineral Density in Treated Celiac Disease

    Directory of Open Access Journals (Sweden)

    Bernard Lemieux

    2001-01-01

    Full Text Available Decreased bone mineral density (BMD has been reported in patients with celiac disease in association with secondary hyperparathyroidism. The present study investigated whether basal parathyroid hormone (PTH remained elevated and whether abnormalities of parathyroid function were still present in celiac disease patients treated with a gluten-free diet. Basal seric measurements of calcium and phosphate homeostasis and BMD were obtained in 17 biopsy-proven patients under treatment for a mean period of 5.7±3.7 years (range 1.1 to 15.9. In addition, parathyroid function was studied with calcium chloride and sodium citrate infusions in seven patients. Basal measurements of patients were compared with those of 26 normal individuals, while parathyroid function results were compared with those of seven sex- and age-matched controls. Basal results were similar in patients and controls except for intact PTH (I-PTH (3.77±0.88 pmol/L versus 2.28±0.63 pmol/L, P<0.001, which was higher in the former group but still within normal limits. Mean 25-hydroxy vitamin D and 1,25-dihydroxy vitamin D values were normal in patients. Parathyroid function results were also found to be similar in both groups. Compared with a reference population of the same age (Z score, patients had significantly lower BMDs of the hip (-0.60±0.96 SDs, P<0.05 and lumbar spine (-0.76±1.15 SDs, P<0.05. T scores were also decreased for the hip (-1.3±0.9 SDs, P<0.0001 and lumbar spine (-1.4±1.35 SDs, P<0.0001, with two to three patients being osteoporotic (T score less than -2.5 SDs and seven to eight osteopenic (T score less than -1 SDs but greater than or equal to -2.5 SDs in at least one site. Height and weight were the only important determinants of BMD values by multivariate or logistical regression analysis in these patients. The results show higher basal I-PTH values with normal parathyroid function in treated celiac disease. Height and weight values are, but I-PTH values are not

  14. Cone photopigment in older subjects: decreased optical density in early age-related macular degeneration

    Science.gov (United States)

    Elsner, Ann E.; Burns, Stephen A.; Weiter, John J.

    2002-01-01

    We measured changes to cone photoreceptors in patients with early age-related macular degeneration. The data of 53 patients were compared with normative data for color matching measurements of long- and middle-wavelength-sensitive cones in the central macula. A four-parameter model quantified cone photopigment optical density and kinetics. Cone photopigment optical density was on average less for the patients than for normal subjects and was uncorrelated with visual acuity. More light was needed to reduce the photopigment density by 50% in the steady state for patients. These results imply that cone photopigment optical density is reduced by factors other than slowed kinetics.

  15. Alterations in grooming activity and syntax in heterozygous SERT and BDNF knockout mice: the utility of behavior-recognition tools to characterize mutant mouse phenotypes.

    Science.gov (United States)

    Kyzar, Evan J; Pham, Mimi; Roth, Andrew; Cachat, Jonathan; Green, Jeremy; Gaikwad, Siddharth; Kalueff, Allan V

    2012-12-01

    Serotonin transporter (SERT) and brain-derived neurotrophic factor (BDNF) are key modulators of molecular signaling, cognition and behavior. Although SERT and BDNF mutant mouse phenotypes have been extensively characterized, little is known about their self-grooming behavior. Grooming represents an important behavioral domain sensitive to environmental stimuli and is increasingly used as a model for repetitive behavioral syndromes, such as autism and attention deficit/hyperactivity disorder. The present study used heterozygous ((+/-)) SERT and BDNF male mutant mice on a C57BL/6J background and assessed their spontaneous self-grooming behavior applying both manual and automated techniques. Overall, SERT(+/-) mice displayed a general increase in grooming behavior, as indicated by more grooming bouts and more transitions between specific grooming stages. SERT(+/-) mice also aborted more grooming bouts, but showed generally unaltered activity levels in the observation chamber. In contrast, BDNF(+/-) mice displayed a global reduction in grooming activity, with fewer bouts and transitions between specific grooming stages, altered grooming syntax, as well as hypolocomotion and increased turning behavior. Finally, grooming data collected by manual and automated methods (HomeCageScan) significantly correlated in our experiments, confirming the utility of automated high-throughput quantification of grooming behaviors in various genetic mouse models with increased or decreased grooming phenotypes. Taken together, these findings indicate that mouse self-grooming behavior is a reliable behavioral biomarker of genetic deficits in SERT and BDNF pathways, and can be reliably measured using automated behavior-recognition technology. Copyright © 2012 Elsevier Inc. All rights reserved.

  16. Decrease in lower level density due to cooling of gas temperature by thermal dissociation of hydrogen in copper vapor laser

    International Nuclear Information System (INIS)

    Watanabe, Ikuo; Hayashi, Kazuo; Iseki, Yasushi; Suzuki, Setsuo; Noda, Etsuo; Morimiya, Osamu

    1995-01-01

    A gas temperature calculation is carried out in the copper vapor laser (CVL) with a beam diameter of 80 mm in the case of H 2 addition into the Ne buffer gas. The on-axis gas temperature decreases to 2800K with 1% concentration of H 2 , whereas the gas temperature is 3400K without H 2 . The on-axis lower level density decreases due to the cooling of the gas temperature. This decrease in the lower level density is thought to bring about a non annular beam profile in the case of H 2 addition. (author)

  17. Quasilinear dynamics of a cloud of hot electrons propagating through a plasma with decreasing density and temperature

    International Nuclear Information System (INIS)

    Foroutan, G.; Khalilpour, H.; Moslehi-Fard, M.; Li, B.; Robinson, P. A.

    2008-01-01

    The effects of plasma inhomogeneities on the propagation of a cloud of hot electrons through a cold background plasma and generation of Langmuir waves are investigated using numerical simulations of the quasilinear equations. It is found that in a plasma with decreasing density the quasilinear relaxation of the electron distribution in velocity space is accelerated and the levels of the generated Langmuir waves are enhanced. The magnitude of the induced emission rate is increased and its maximum value moves to lower velocities. Due to density gradient the height of plateau shows an increase at small distances and a corresponding decrease at large distances. It is also found that in a plasma with decreasing temperature, the relaxation of the beam is retarded, the spectral density of Langmuir waves is broadened, and the height of the plateau decreases below its value in a uniform plasma. In the presence of both density and temperature gradients, at given position, the height and upper boundary of the plateau and the level of Langmuir waves are all increased at small velocities. The spatial expansion of the beam is increased by the plasma inhomogeneities, but its average velocity of propagation decreases. Initially, at a given position, the velocity at the upper boundary of the plateau is smaller in the presence of the density gradient than in the uniform plasma but the reverse is true at longer times. Due to temperature gradient, at large times and small distances, the upper boundary of the plateau is increased above its value in the uniform plasma. Because of fast relaxation, the value of the lower boundary of the plateau in the plasma with decreasing density is always less than its value in the uniform plasma. It is found that the local velocity of the beam decreases when the density gradient is present. The local velocity spread of the beam remains unchanged during the propagation of the beam in the uniform plasma, but increases in the presence of inhomogeneities.

  18. A 90 minute soccer match decreases triglyceride and low density lipoprotein but not high-density lipoprotein and cholesterol levels

    Directory of Open Access Journals (Sweden)

    Nader - Rahnama

    2009-11-01

    Full Text Available

    • BACKGROUND: The association between the lipid profiles level and the incidence and severity of coronary heart disease (CHD is very pronounced in epidemiological studies, and an inverse relation between physical fitness and the incidence of coronary heart disease has been observed in many studies. The aim of this study was to investigate the impact of a soccer match on lipid parameters of professional soccer players.
    • METHODS: Twenty two professional soccer players participated in the study. Blood (10ml for determination of lipid profiles was obtained at rest and immediately after a 90 minute soccer match. Lipid parameters were measured using Boehringer Mannheim kits and Clinilab and BioMerieux analyser.
    • RESULTS: The results of this study showed that the triglyceride was significantly higher before the match than afterwards (159.09 ± 58.2 vs. 88.63 ± 34.1 mg/dl, p < 0.001, whereas the low-density lipoprotein (LDL was lower before the match than after it (98.04 ± 28.9 vs. 112.31 ± 30.5 mg/dl. Moreover, there were no significant differences in cholesterol concentration (171.4 ± 30.28 mg/dl vs. 173.18 ± 32.75 mg/dl and high-density lipoprotein (HDL concentration (34.04 ± 5.58 mg/dl vs. 34.4 ± 4.6 mg/dl between before and after the match.
    • CONCLUSIONS: Although the soccer competitive match has no favourable acute effect on lipid

    • Problems of the decrease in periventricular density due to hypoxia in computer tomograms of new-born infants

      Energy Technology Data Exchange (ETDEWEB)

      Kotlarek, F.; Bruell, D.; Sturm, K.W.; Zeumer, H.

      200 premature and mature neonates with clinical evidence of hypoxia or traumatic encephalopathy were examined by cranial computerized tomography (CT) during the first two weeks postnatally. The findings were compared with those in a control-group consisting of 14 neonates with extraneural malformations. Cerebral hemorrhages were easily identified by their high density, in CT images. Bilateral areas of lowered density within the periventricular white matter, however, could not always be attributed to irreversible tissue damage prior to about 14 days after the hypoxic event in term newborns, and in preterm infants even later. During this early period of life an apparent decrease of periventricular density was regularily observed that must not be mistaken for a pathological change. In two cases persistent periventricular areas of decreased density were caused by neuropathologically verified foci of incomplete leucomalacia.

    • The problems of the decrease in periventricular density due to hypoxia in computer tomograms of new-born infants

      International Nuclear Information System (INIS)

      Kotlarek, F.; Bruell, D.; Sturm, K.W.; Zeumer, H.

      1982-01-01

      200 premature and mature neonates with clinical evidence of hypoxia or traumatic encephalopathy were examined by cranial computerized tomography (CT) during the first two weeks postnatally. The findings were compared with those in a ''control-group'' consisting of 14 neonates with extraneural malformations. Cerebral hemorrhages were easily identified by their high density, in CT images. Bilateral areas of lowered density within the periventricular white matter, however, could not always be attributed to irreversible tissue damage prior to about 14 days after the hypoxic event in term newborns, and in preterm infants even later. During this early period of life an apparent decrease of periventricular density was regularily observed that must not be mistaken for a pathological change. In two cases persistent periventricular areas of decreased density were caused by neuropathologically verified foci of incomplete leucomalacia. (orig.) [de

  1. Improvement of the environmental and operational characteristics of vehicles through decreasing the motor fuel density.

    Science.gov (United States)

    Magaril, Elena

    2016-04-01

    The environmental and operational characteristics of motor transport, one of the main consumers of motor fuel and source of toxic emissions, soot, and greenhouse gases, are determined to a large extent by the fuel quality which is characterized by many parameters. Fuel density is one of these parameters and it can serve as an indicator of fuel quality. It has been theoretically substantiated that an increased density of motor fuel has a negative impact both on the environmental and operational characteristics of motor transport. The use of fuels with a high density leads to an increase in carbonization within the engine, adversely affecting the vehicle performance and increasing environmental pollution. A program of technological measures targeted at reducing the density of the fuel used was offered. It includes a solution to the problem posed by changes in the refining capacities ratio and the temperature range of gasoline and diesel fuel boiling, by introducing fuel additives and adding butanes to the gasoline. An environmental tax has been developed which allows oil refineries to have a direct impact on the production of fuels with improved environmental performance, taking into account the need to minimize the density of the fuel within a given category of quality.

  2. Canopy gaps decrease microbial densities and disease risk for a shade-intolerant tree species

    Science.gov (United States)

    Kurt O. Reinhart; Alejandro A. Royo; Stacie A. Kageyama; Keith. Clay

    2010-01-01

    Canopy disturbances such as windthrowevents have obvious impacts on forest structure and composition aboveground, but changes in soil microbial communities and the consequences of these changes are less understood.We characterized the densities of a soil-borne pathogenic oomycete (Pythium) and a common saprotrophic zygomycete (Mortierella...

  3. Short-term hyperglycemia increases endothelial glycocalyx permeability and acutely decreases lineal density of capillaries with flowing red blood cells

    NARCIS (Netherlands)

    Zuurbier, Coert J.; Demirci, Cihan; Koeman, Anneke; Vink, Hans; Ince, Can

    2005-01-01

    Hyperglycemia is becoming recognized as an important risk factor for microvascular dysfunction. We hypothesized that short-term hyperglycemia, either on the scale of hours or weeks, alters the barrier function and the volume of the endothelial glycocalyx and decreases functional capillary density

  4. Effectiveness and feasibility of lowering playground density during recess to promote physical activity and decrease sedentary time at primary school.

    Science.gov (United States)

    D'Haese, Sara; Van Dyck, Delfien; De Bourdeaudhuij, Ilse; Cardon, Greet

    2013-12-10

    This pilot study aimed at investigating the effectiveness of lowering playground density on increasing children's physical activity and decreasing sedentary time. Also the feasibility of this intervention was tested. Data were collected in September and October 2012 in three Belgian schools in 187, 9-12 year old children. During the intervention, playground density was decreased by splitting up recesses and decreasing the number of children sharing the playground. A within-subject design was used. Children wore accelerometers during the study week. Three-level (class - participant - measurement (baseline or intervention)) linear regression models were used to determine intervention effects. After the intervention week the school principals filled out a questionnaire concerning the feasibility of the intervention. The available play space was 12.18 ± 4.19 m²/child at baseline and increased to 24.24 ± 8.51 m²/child during intervention. During the intervention sedentary time decreased (-0.58 min/recess; -3.21%/recess) and moderate-to-vigorous physical activity (+1.04 min/recess; +5.9%/recess) increased during recess and during the entire school day (sedentary time: -3.29%/school day; moderate-to-vigorous physical activity +1.16%/school day). All principals agreed that children enjoyed the intervention; but some difficulties were reported. Lowering playground density can be an effective intervention for decreasing children's sedentary time and increasing their physical activity levels during recess; especially in least active children.

  5. Hyponatremia and decreased bone density in adolescent inpatients diagnosed with anorexia nervosa.

    Science.gov (United States)

    Levy-Shraga, Yael; David, Dana; Vered, Iris; Kochavi, Brigitte; Stein, Daniel; Modan-Moses, Dalit

    2016-10-01

    Recent studies demonstrated an association between low serum sodium levels and reduced bone density. Patients with anorexia nervosa (AN) are at greater risk for osteoporosis as well as for hyponatremia. The aim of the present study was to assess the association between hyponatremia and bone mineral density (BMD) in a large cohort of adolescent inpatients with AN. A historic cohort study of 174 adolescent females (mean age 15.7 ± 1.8 y) hospitalized because of AN between 2003 and 2013. Demographic and clinical data, including age, psychiatric comorbidity, anthropometric measurements, laboratory tests, and BMD scores were obtained from the patients' medical charts. Mean lumbar spine BMD z-score of the patients was lower than expected in the normal population (mean -1.5 ± 1.2) and positively correlated with body mass index standard deviation score (r = 0.42, P adolescent females with AN. Additional studies are required to evaluate whether the correction of hyponatremia will improve BMD. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. Evidence for top-heavy stellar initial mass functions with increasing density and decreasing metallicity

    Science.gov (United States)

    Marks, Michael; Kroupa, Pavel; Dabringhausen, Jörg; Pawlowski, Marcel S.

    2012-05-01

    Residual-gas expulsion after cluster formation has recently been shown to leave an imprint in the low-mass present-day stellar mass function (PDMF) which allowed the estimation of birth conditions of some Galactic globular clusters (GCs) such as mass, radius and star formation efficiency. We show that in order to explain their characteristics (masses, radii, metallicity and PDMF) their stellar initial mass function (IMF) must have been top heavy. It is found that the IMF is required to become more top heavy the lower the cluster metallicity and the larger the pre-GC cloud-core density are. The deduced trends are in qualitative agreement with theoretical expectation. The results are consistent with estimates of the shape of the high-mass end of the IMF in the Arches cluster, Westerlund 1, R136 and NGC 3603, as well as with the IMF independently constrained for ultra-compact dwarf galaxies (UCDs). The latter suggests that GCs and UCDs might have formed along the same channel or that UCDs formed via mergers of GCs. A Fundamental Plane is found which describes the variation of the IMF with density and metallicity of the pre-GC cloud cores. The implications for the evolution of galaxies and chemical enrichment over cosmological times are expected to be major.

  7. Assessment of risk factors bone mineral density decrease in adolescents with dentoalveolar anomalies

    Directory of Open Access Journals (Sweden)

    Yu. A. Kalinichenko

    2016-01-01

    Full Text Available The aim of the study was to investigate the prevalence of osteopenia and its relationship with combined orthodontic and somatic disorders in adolescents to build a working model of the formation of osteopenia, identifying the most significant risk factors.Materials and methods. 525 grade 5–10 schoolchildren from Lugansk’ secondary schools and orphans school aged 12–17 years were examined. We assessed the state of dental hard tissues and periodontal tissues, the state of oral health, the prevalence of different types of dentoalveolar anomalies (DAA and chronic diseases of the gastrointestinal tract (CDGIT. Bone mineral density was assessed by ultrasound osteodensitometry (SONOST-2000. The level of mineralization of the skeleton was assessed by speed of sound (SOS, m/s, it depends on the degree of elasticity and density of the bone tissue. We analyzed the performance – Broadband Ultrasound Attenuation (BUA – broadband absorption, dB/MHz, it’s characterized by loss of the intensity of the ultrasound in the absorption medium, as well as the number, size and spatial orientation of the trabecular bone. The statistical processing of the obtained results was carried out with application program package Statistic 6.0.Results. During study the combined pathology as the dentoalveolar anomalies and chronic diseases of the gastrointestinal tract were identified in 68,4% of adolescents. Light form of osteopenia met in every third patient with combined pathology. Certain combinations of factors that have a negative effect to bone mineral density were discovered, and we have created the model of osteopenia in adolescents. Underweight is one of the leading factors in the osteopenia development, the highest incidence of osteopenia were in children who had weight deficit (69,5%, and children with a harmonic age loss of the weight and growth parameters (70,7%.Conclusion. Adolescents with DAA and chronic diseases of the gastrointestinal

  8. Perinatal phencyclidine administration decreases the density of cortical interneurons and increases the expression of neuregulin-1.

    Science.gov (United States)

    Radonjić, Nevena V; Jakovcevski, Igor; Bumbaširević, Vladimir; Petronijević, Nataša D

    2013-06-01

    Perinatal phencyclidine (PCP) administration in rat blocks the N-methyl D-aspartate receptor (NMDAR) and causes symptoms reminiscent of schizophrenia in human. A growing body of evidence suggests that alterations in γ-aminobutyric acid (GABA) interneuron neurotransmission may be associated with schizophrenia. Neuregulin-1 (NRG-1) is a trophic factor important for neurodevelopment, synaptic plasticity, and wiring of GABA circuits. The aim of this study was to determine the long-term effects of perinatal PCP administration on the projection and local circuit neurons and NRG-1 expression in the cortex and hippocampus. Rats were treated on postnatal day 2 (P2), P6, P9, and P12 with either PCP (10 mg/kg) or saline. Morphological studies and determination of NRG-1 expression were performed at P70. We demonstrate reduced densities of principal neurons in the CA3 and dentate gyrus (DG) subregions of the hippocampus and a reduction of major interneuronal populations in all cortical and hippocampal regions studied in PCP-treated rats compared with controls. For the first time, we show the reduced density of reelin- and somatostatin-positive cells in the cortex and hippocampus of animals perinatally treated with PCP. Furthermore, an increase in the numbers of perisomatic inhibitory terminals around the principal cells was observed in the motor cortex and DG. We also show that perinatal PCP administration leads to an increased NRG-1 expression in the cortex and hippocampus. Taken together, our findings demonstrate that perinatal PCP administration increases NRG-1 expression and reduces the number of projecting and local circuit neurons, revealing complex consequences of NMDAR blockade.

  9. Decreased striatal D2 receptor density associated with severe behavioral abnormality in Alzheimer's disease

    International Nuclear Information System (INIS)

    Tanaka, Yasuhiro; Meguro, Kenichi; Yamaguchi, Satoshi

    2003-01-01

    Since patients manifesting behavioral and psychological symptoms of dementia (BPSD) are a burden for their families and caregivers, the underlying neurobiological mechanism of this condition should be clarified. Using positron emission tomography (PET), we previously reported that wandering behavior in dementia was associated with a disturbed dopaminergic neuron system. We herein investigated the relationship between the severity of BPSD and the striatal D 2 receptor density in Alzheimer's disease (AD). Ten patients with probable AD as per the National Institute of Neurological and Communicative Disorders and Stroke (NINCDS) and the AD and Related Disorders Association (ADRDA) criteria and five normal subjects were examined with PET. The tracer used was [ 11 C]raclopride (D 2 antagonist). The uptake of [ 11 C]raclopride was calculated as the estimation of binding potential (BP) of the striatum to the cerebellum. The AD patients were institutionalized in multiple nursing homes, and their BPSD were evaluated by the Behavioral Pathology in AD Frequency Weighted Severity Scale (BEHAVE-AD-FW) scale (Reisberg). There was a significant inverse Spearman's correlation between BEHAVE-AD-FW score and the BP, especially between the score of the behavioral domain and the BP values. The BP was found to be lower in severer BPSD patients. Patients with AD who manifest severe BPSD may have some dysfunction of striatal dopamine metabolism compared with those without BPSD. (author)

  10. Self-Explanation and Reading Strategy Training (SERT) Improves Low-Knowledge Students' Science Course Performance

    Science.gov (United States)

    McNamara, Danielle S.

    2017-01-01

    This study demonstrates the generalization of previous laboratory results showing the benefits of Self-Explanation Reading Training (SERT) to college students' course exam performance. The participants were 265 students enrolled in an Introductory Biology course, 59 of whom were provided with SERT. The results showed that SERT benefited students…

  11. Increased extracellular matrix density decreases MCF10A breast cell acinus formation in 3D culture conditions.

    Science.gov (United States)

    Lance, Amanda; Yang, Chih-Chao; Swamydas, Muthulekha; Dean, Delphine; Deitch, Sandy; Burg, Karen J L; Dréau, Didier

    2016-01-01

    The extracellular matrix (ECM) contributes to the generation and dynamic of normal breast tissue, in particular to the generation of polarized acinar and ductal structures. In vitro 3D culture conditions, including variations in the composition of the ECM, have been shown to directly influence the formation and organization of acinus-like and duct-like structures. Furthermore, the density of the ECM appears to also play a role in the normal mammary tissue and tumour formation. Here we show that the density of the ECM directly influences the number, organization and function of breast acini. Briefly, non-malignant human breast MCF10A cells were incubated in increasing densities of a Matrigel®-collagen I matrix. Elastic moduli near and distant to the acinus structures were measured by atomic force microscopy, and the number of acinus structures was determined. Immunochemistry was used to investigate the expression levels of E-cadherin, laminin, matrix metalloproteinase-14 and ß-casein in MCF10A cells. The modulus of the ECM was significantly increased near the acinus structures and the number of acinus structures decreased with the increase in Matrigel-collagen I density. As evaluated by the expression of laminin, the organization of the acinus structures present was altered as the density of the ECM increased. Increases in both E-cadherin and MMP14 expression by MCF10A cells as ECM density increased were also observed. In contrast, MCF10A cells expressed lower ß-casein levels as the ECM density increased. Taken together, these observations highlight the key role of ECM density in modulating the number, organization and function of breast acini. Copyright © 2013 John Wiley & Sons, Ltd.

  12. Histone deacetylase 3 depletion in osteo/chondroprogenitor cells decreases bone density and increases marrow fat.

    Directory of Open Access Journals (Sweden)

    David F Razidlo

    2010-07-01

    Full Text Available Histone deacetylase (Hdac3 is a nuclear enzyme that contributes to epigenetic programming and is required for embryonic development. To determine the role of Hdac3 in bone formation, we crossed mice harboring loxP sites around exon 7 of Hdac3 with mice expressing Cre recombinase under the control of the osterix promoter. The resulting Hdac3 conditional knockout (CKO mice were runted and had severe deficits in intramembranous and endochondral bone formation. Calvarial bones were significantly thinner and trabecular bone volume in the distal femur was decreased 75% in the Hdac3 CKO mice due to a substantial reduction in trabecular number. Hdac3-CKO mice had fewer osteoblasts and more bone marrow adipocytes as a proportion of tissue area than their wildtype or heterozygous littermates. Bone formation rates were depressed in both the cortical and trabecular regions of Hdac3 CKO femurs. Microarray analyses revealed that numerous developmental signaling pathways were affected by Hdac3-deficiency. Thus, Hdac3 depletion in osterix-expressing progenitor cells interferes with bone formation and promotes bone marrow adipocyte differentiation. These results demonstrate that Hdac3 inhibition is detrimental to skeletal health.

  13. Heart valve cardiomyocytes of mouse embryos express the serotonin transporter SERT

    International Nuclear Information System (INIS)

    Pavone, Luigi Michele; Spina, Anna; Lo Muto, Roberta; Santoro, Dionea; Mastellone, Vincenzo; Avallone, Luigi

    2008-01-01

    Multiple evidence demonstrate a role for serotonin and its transporter SERT in heart valve development and disease. By utilizing a Cre/loxP system driven by SERT gene expression, we recently demonstrated a regionally restricted distribution of SERT-expressing cells in developing mouse heart. In order to characterize the cell types exhibiting SERT expression within the mouse heart valves at early developmental stages, in this study we performed immunohistochemistry for Islet1 (Isl1) and connexin-43 (Cx-43) on heart sections from SERT Cre/+ ;ROSA26R embryos previously stained with X-gal. We observed the co-localization of LacZ staining with Isl1 labelling in the outflow tract, the right ventricle and the conal region of E11.5 mouse heart. Cx-43 labelled cells co-localized with LacZ stained cells in the forming atrioventricular valves. These results demonstrate the cardiomyocyte phenotype of SERT-expressing cells in heart valves of the developing mouse heart, thus suggesting an active role of SERT in early heart valve development.

  14. Placed in a steady magnetic field, the flux density inside a permalloy-shielded volume decreases over hours and days

    Science.gov (United States)

    Feinberg, Benedict; Gould, Harvey

    2018-03-01

    Following the application of an external magnetic field to a thin-walled demagnetized Permalloy cylinder, the magnetic flux density at the center of the shielded volume decreases by roughly 20% over periods of hours to days. We measured this effect for applied magnetic fields from 0.48 A/m to 16 A/m, the latter being comparable to the Earths magnetic field at its weakest point. Delayed changes in magnetic flux density are also observed following alternating current demagnetization. We attribute these effects to delayed changes in magnetization, which have previously been observed in thin Permalloy films and small bulk samples of ferromagnetic materials. Phenomenological models of thermal activation are discussed. Some possible effects on experiments that rely on static shielding are noted.

  15. Thinning of young Douglas-fir forests decreases density of northern flying squirrels in the Oregon Cascades

    Science.gov (United States)

    Manning, Tom; Hagar, Joan C.; McComb, Brenda C.

    2012-01-01

    Large-scale commercial thinning of young forests in the Pacific Northwest is currently promoted on public lands to accelerate the development of late-seral forest structure for the benefit of wildlife species such as northern spotted owls (Strix occidentalis caurina) and their prey, including the northern flying squirrel (Glaucomys sabrinus). Attempts to measure the impact of commercial thinning on northern flying squirrels have mostly addressed short-term effects (2–5 years post-thinning) and the few published studies of longer-term results have been contradictory. We measured densities of northern flying squirrels 11–13 years after thinning of young (55–65 years) Douglas-fir forest stands in the Cascade Range of Oregon, as part of the Young Stand Thinning & Diversity Study. The study includes four replicate blocks, each consisting of an unthinned control stand and one stand each of the following thinning treatments: Heavy Thin; Light Thin; and Light Thin with Gaps. Thinning decreased density of northern flying squirrels, and squirrel densities were significantly lower in heavily thinned stands than in more lightly thinned stands. Regression analysis revealed a strong positive relationship of flying squirrel density with density of large (>30 cm diameter) standing dead trees and a negative relationship with percent cover of low understory shrubs. Maintaining sufficient area and connectivity of dense, closed canopy forest is recommended as a strategy to assure that long-term goals of promoting late-seral structure do not conflict with short-term habitat requirements of this important species.

  16. Sudden post-midnight decrease in equatorial F-region electron densities associated with severe magnetic storms

    Directory of Open Access Journals (Sweden)

    D. R. Lakshmi

    1997-03-01

    Full Text Available A detailed analysis of the responses of the equatorial ionosphere to a large number of severe magnetic storms shows the rapid and remarkable collapse of F-region ionisation during post-midnight hours; this is at variance with the presently accepted general behaviour of the low-latitude ionosphere during magnetic storms. This paper discusses such responses as seen in the ionosonde data at Kodaikanal (Geomagn. Lat. 0.6 N. It is also observed that during magnetic storm periods the usual increase seen in the h'F at Kodaikanal during sunset hours is considerably suppressed and these periods are also characterised by increased foF2 values. It is suggested that the primary process responsible for these dramatic pre- and post-midnight changes in foF2 during magnetic storms could be due to changes in the magnitude as well as in the direction of usual equatorial electric fields. During the post-midnight periods the change in electric-field direction from westward to eastward for a short period causes an upward E × B plasma drift resulting in increased h'F and decreased electron densities in the equatorial region. In addition, it is also suggested that the enhanced storm-induced meridional winds in the thermosphere, from the poles towards the equator, may also cause the decreases in electron density seen during post-midnight hours by spatially transporting the F-region ionisation southwards away from Kodaikanal. The paper also includes a discussion on the effects of such decreases in ionisation on low-latitude HF communications.

  17. Serotonin receptor, SERT mRNA and correlations with symptoms in males with alcohol dependence and suicide.

    Science.gov (United States)

    Thompson, P M; Cruz, D A; Olukotun, D Y; Delgado, P L

    2012-09-01

    This study tested the hypothesis that abnormalities in components of the serotonin (5HT) system in the prefrontal cortex are associated with suicide in alcohol-dependent subjects. Second, we assessed the relationship of lifetime impulsivity and mood symptoms with prefrontal cortex 5-HT measures. Tissue was obtained from Brodmann's areas (BA) 9 and 24 in postmortem samples of individuals who were alcohol dependent with suicide (n = 5), alcohol dependent without suicide (n = 9) and normal controls (n = 5). Serotonin receptor (5HT) and serotonin reuptake transporter (SERT) mRNA were measured. Interviews with next of kin estimated lifetime impulsivity and mood symptoms in the last week of life. Serotonin receptor 1A (5HT1A) mRNA in BA 9 was elevated in the alcohol dependence without suicide group compared with controls. In the alcohol dependence with suicide group, anxiety symptoms were associated with decreased BA 24 SERT mRNA and depressive symptoms with BA 9 5HT1A mRNA expression. In the alcohol dependent only group impulsivity is correlated with increased BA 9, and BA 24 serotonin receptor 2A mRNA. Our data suggest region-specific change, rather than global serotonin blunting is involved in alcohol dependence and suicide. It also suggests that symptoms are differentially influenced by prefrontal cortex serotonin receptor mRNA levels. © 2011 John Wiley & Sons A/S.

  18. Progressive Decrease of Peripapillary Angioflow Vessel Density During Structural and Visual Field Progression in Early Primary Open-angle Glaucoma.

    Science.gov (United States)

    Holló, Gábor

    2017-07-01

    To present a case of early primary open-angle glaucoma in which retinal nerve fiber layer thickness (RNFLT), ganglion cell complex (GCC), and visual field progression were accompanied with significant progression of peripapillary angioflow vessel density (PAFD) measured with optical coherence tomographic angiography. A 68-year-old female patient who was under topical intraocular pressure (IOP) lowering medication for 20 years for ocular hypertension of the right and preperimetric primary open-angle glaucoma of the left eye (with reproducible inferotemporal and superotemporal neuroretinal rim and RNFL loss) was prospectively imaged with the AngioVue OCT for RNFLT, GCC thickness, and PAFD, and investigated with the Octopus Normal G2 visual field test on the same days at 6-month intervals for 18 months, while the IOP of the left eye escaped from control. IOP of the left eye fluctuated between 14 and 30 mm Hg in the study period. RNFLT, GCC thickness, and peripapillary PAFD all decreased significantly (linear regression analysis, P=0.030, 0.040, and 0.020, respectively), and a significant 2.1 dB/y progression was seen for a superior visual field cluster. The RNFLT, peripapillary PAFD, and visual field of the right eye remained normal and unchanged. In our case IOP elevation, glaucomatous visual field conversion, and structural progression were accompanied with significant progressive decrease of peripapillary PAFD. The simultaneous thinning of RNFLT and GCC and decrease of peripapillary PAFD suggest that PAFD may potentially be an additional indicator of early progression in primary open-angle glaucoma.

  19. SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder.

    Science.gov (United States)

    Wendland, Jens R; DeGuzman, Theresa B; McMahon, Francis; Rudnick, Gary; Detera-Wadleigh, Sevilla D; Murphy, Dennis L

    2008-02-01

    SERT I425V, an uncommon missense single nucleotide polymorphism producing a gain-of-function of the serotonin transporter (SERT), was originally found to segregate with a primarily obsessive-compulsive disorder (OCD) but complexly comorbid phenotype in two unrelated families. As two individuals with SERT I425V and OCD also had Asperger syndrome (AS), an autism spectrum disorder, and as other rare SERT variants have recently shown significant associations with autism, we set out to extend our original OCD study by genotyping additional autism/AS and OCD samples. Case-control association study of SERT I425V in 210 AS/autism probands and 215 controls, plus 335 OCD probands and their family members. SERT I425V was not found in any of the individuals with AS/autism, OCD alone or OCD comorbid with AS and other disorders, or in controls. This results in new estimates of SERT I425V having a 1.5% prevalence in 530 individuals with OCD from five unrelated families genotyped by us and by one other group and a 0.23% frequency in four control populations totaling 1300 individuals, yielding a continuing significant OCD-control difference (Fisher's exact test corrected for family coefficient of identity P=0.004, odds ratio=6.54). As several other uncommon, less well quantitated genetic variations occur with an OCD phenotype, including chromosomal anomalies and some other rare gene variants (SGCE, GCH1 and SLITRK1), a tentative conclusion is that OCD resembles other complex disorders in being etiologically heterogeneous and in having both highly penetrant familial subtypes associated with rare alleles or chromosomal anomalies, as well as having a more common, polygenetic form that may involve polymorphisms in such genes as BDNF, COMT, GRIN2beta, TPH2, HTR2A and SLC1A1.

  20. Distal femoral bone mineral density decreases following patellofemoral arthroplasty: 1-year follow-up study of 14 patients

    Directory of Open Access Journals (Sweden)

    Innocenti Bernardo

    2010-04-01

    Full Text Available Abstract Background The bone mineral density (BMD of the distal femur decreases by 16-36% within one year after total knee arthroplasty (TKA because of the femoral component's stress-shielding effect. The aim of this prospective study was to determine the quantitative change from the baseline BMD in the distal femur 1 year after patellofemoral arthroplasty using dual-energy X-ray absorptiometry (DXA. Methods Between December 2007 and December 2008, 14 patients had patellofemoral arthroplasty for isolated patellofemoral osteoarthritis. Distal femoral BMD was assessed using DXA in 2 regions of interest (ROI on the lateral view 2 weeks before and 12 months after patellofemoral arthroplasty. The contra-lateral knee was used as a control, with BMD measurements performed in identical ROIs. Results The mean change from baseline BMD in the operated knees after 1 year was -0.169 g/cm2 (95% CI: -0.293 to -0.046 g/cm2 behind the anterior flange (-15%, and -0.076 g/cm2 (95% CI: -0.177 to 0.024 g/cm2 in the supracondylar area 1 cm above the prosthesis (-8% (p = 0.01 and p = 0.13, respectively. The mean change from baseline BMD in the non-operated knees after 1 year was 0.016 g/cm2 (95% CI: -0.152 to 0.185 g/cm2 behind the anterior flange (2%, and 0.023 g/cm2 (95% CI: -0.135 to 0.180 g/cm2 in the supracondylar area 1 cm above the prosthesis (2% (p = 0.83, and p = 0.76, respectively. Conclusions Our findings suggest that patellofemoral arthroplasty results in a statistically significant decrease in BMD behind the anterior flange.

  1. MiR-33a Decreases High-Density Lipoprotein-Induced Radiation Sensitivity in Breast Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Wolfe, Adam R.; Bambhroliya, Arvind [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Reddy, Jay P. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Debeb, Bisrat G. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Huo, Lei [Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Larson, Richard; Li, Li [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Ueno, Naoto T. [Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Woodward, Wendy A., E-mail: wwoodward@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2016-06-01

    Purpose: We previously showed that high-density lipoprotein (HDL) radiosensitizes inflammatory breast cancer (IBC) cells in vitro and is associated with better local control after radiation therapy in IBC patients. The microRNA miR-33 family negatively regulates the adenosine triphosphate binding cassette transporter subfamily A member 1. We hypothesized that variations in miR-33a expression in IBC cancer cells versus non-IBC cells would correlate with radiation sensitivity following exposure to HDL in vitro. Methods and Materials: MiR-33a expression was analyzed by reverse transcriptase–polymerase chain reaction in 4 cell lines representing common clinical breast cancer subtypes. Overexpression and knockdown of miR-33a was demonstrated via transfection of an miR-33a mimic or an anti-miR-33a construct in high- and low-expressing miR-33a cell lines. Clonogenic survival in vitro in these cells was quantified at baseline and following HDL treatment. MiR-33a expression on distant relapse-free survival (DRFS) of 210 cases downloaded from the Oxford breast cancer dataset was determined. Results: Expression levels of miR-33a were lower in IBC cell lines and IBC tumor samples than in non-IBC cell lines and normal breast tissue. Cholesterol concentrations in the cell membranes were higher in IBC cells than in non-IBC cells. Clonogenic survival following 24 hours of HDL treatment was decreased in response to irradiation in the low-miR-33a–expressing cell lines SUM149 and KPL4, but survival following HDL treatment decreased in the high-miR-33a–expressing cell lines MDA-MB-231 and SUM159. In the high-miR-33a–expressing cell lines, anti-miR-33a transfection decreased radiation resistance in clonogenic assays. Conversely, in the low-miR-33a–expressing cell lines, the miR-33a mimic reversed the HDL-induced radiation sensitization. Breast cancer patients in the top quartile based on miR-33a expression had markedly lower rates of DRFS than the bottom quartile (P

  2. MiR-33a Decreases High-Density Lipoprotein-Induced Radiation Sensitivity in Breast Cancer

    International Nuclear Information System (INIS)

    Wolfe, Adam R.; Bambhroliya, Arvind; Reddy, Jay P.; Debeb, Bisrat G.; Huo, Lei; Larson, Richard; Li, Li; Ueno, Naoto T.; Woodward, Wendy A.

    2016-01-01

    Purpose: We previously showed that high-density lipoprotein (HDL) radiosensitizes inflammatory breast cancer (IBC) cells in vitro and is associated with better local control after radiation therapy in IBC patients. The microRNA miR-33 family negatively regulates the adenosine triphosphate binding cassette transporter subfamily A member 1. We hypothesized that variations in miR-33a expression in IBC cancer cells versus non-IBC cells would correlate with radiation sensitivity following exposure to HDL in vitro. Methods and Materials: MiR-33a expression was analyzed by reverse transcriptase–polymerase chain reaction in 4 cell lines representing common clinical breast cancer subtypes. Overexpression and knockdown of miR-33a was demonstrated via transfection of an miR-33a mimic or an anti-miR-33a construct in high- and low-expressing miR-33a cell lines. Clonogenic survival in vitro in these cells was quantified at baseline and following HDL treatment. MiR-33a expression on distant relapse-free survival (DRFS) of 210 cases downloaded from the Oxford breast cancer dataset was determined. Results: Expression levels of miR-33a were lower in IBC cell lines and IBC tumor samples than in non-IBC cell lines and normal breast tissue. Cholesterol concentrations in the cell membranes were higher in IBC cells than in non-IBC cells. Clonogenic survival following 24 hours of HDL treatment was decreased in response to irradiation in the low-miR-33a–expressing cell lines SUM149 and KPL4, but survival following HDL treatment decreased in the high-miR-33a–expressing cell lines MDA-MB-231 and SUM159. In the high-miR-33a–expressing cell lines, anti-miR-33a transfection decreased radiation resistance in clonogenic assays. Conversely, in the low-miR-33a–expressing cell lines, the miR-33a mimic reversed the HDL-induced radiation sensitization. Breast cancer patients in the top quartile based on miR-33a expression had markedly lower rates of DRFS than the bottom quartile (P

  3. On the secular decrease of radio emission flux densities of the supernova remnants of Cassiopeia A and Taurus A at frequency 927 MHz

    International Nuclear Information System (INIS)

    Vinyajkin, E.N.; Razin, V.A.

    1979-01-01

    Relative measurements of the radio emission flux densities of the supernova remnants of Cassiopeia A and Taurus A were made at the frequency 927 MHz to investigate the secular decrease of their intensity. Experiments were fulfilled in October-December 1977 at the 10-meter radio telescope of the radioastronomical station Staraya Pustyn' (NIRFI). The radio galaxied of Cygnus A, Virgo A and Orion Nebula were taken as the comparison sources. The comparison of the data obtained with the results of absolute measurements carried out in October 1962 permits to state that during 15 years the radio emission flux density of Cassiopeia A decreased by (14.2+-0.6)% (the average annual decrease amounts to (0.95+-O.04)%) and the radio emission flux density of Taurus A decreased by (2.7+-0.1)% (the annual decrease is (0.18+-0.01)%)

  4. Geologia e metáforas geológicas em Os sertões Geology and geological metaphor in Os sertões

    Directory of Open Access Journals (Sweden)

    José Carlos Barreto de Santana

    1998-07-01

    Full Text Available Neste artigo é feita uma interpretação da construção do conhecimento geológico do principal livro de Euclides da Cunha. Visando caracterizar este conhecimento, são buscadas em cadernetas de anotações, reportagens e artigos de e sobre Euclides da Cunha e no próprio livro, as evidências que possam nortear o entendimento de por que o conteúdo geológico ganha tão forte significação em Os sertões, a ponto de se constituir em elemento para construções metafóricas em momentos importantes da sua narrativa. Partindo dos escritos de Euclides da Cunha, relacionados à guerra de Canudos, mas anteriores ao livro, busco uma interpretação sobre a maneira como se processava o conhecimento do engenheiro nas suas mediações com autores e trabalhos das ciências naturais e mais especificamente geológicas, o que significa, em certos momentos, uma comparação textual de Os sertões com livros e artigos, cujas evidências apontem a possibilidade de terem servido de fonte para o escritor.The article interprets the construction of geological knowledge in Euclides da Cunha’s major work. Notebooks, news reports, and articles by and about Cunha and his book offer up clues as to why geological content gains such import in Os sertões - even constituting an element for metaphorical constructions at key points in the narrative. Based on Cunha’s writings on the battle of Canudos dated prior to publication of Os sertões, the article offers an interpretation of how this engineer’s knowledge was processed in his contact with authors and works from the natural sciences, especially geology. Textual comparisons are made between Os sertões and books and articles which appear to have served as sources for Cunha.

  5. Grande Sertão: Veredas – literatura e memória

    Directory of Open Access Journals (Sweden)

    Márcio Henrique Muraca

    2012-04-01

    Full Text Available Muito já se escreveu sobre Grande Sertão: Veredas, sobretudo a respeito do conceito de sertão como microcosmo, bem como, em termos de linguagem, da técnica narrativa do monólogo-diálogo. Neste artigo, pretende-se investigar os elementos de memória presentes na obra. O produto da tentativa do narrador-protagonista Riobaldo de entender o sentido de sua vida ao rememorar eventos tem como resultado um tipo de relato memorialístico. Ainda que tais eventos sejam ficção, Guimarães Rosa os situa em um plano temporal e espacial concretos, o que permite revelar um enquadramento social a partir dessa “memória individual” de Riobaldo enlaçada à memória coletiva do sertão. O diálogo teórico abarca dois textos básicos, o de Eduardo F. Coutinho, sobre Grande Sertão: Veredas, e os estudos de Marina Maluf sobre memória.

  6. Decreased sleep spindle density in patients with idiopathic REM sleep behavior disorder and patients with Parkinson's disease.

    Science.gov (United States)

    Christensen, Julie A E; Kempfner, Jacob; Zoetmulder, Marielle; Leonthin, Helle L; Arvastson, Lars; Christensen, Søren R; Sorensen, Helge B D; Jennum, Poul

    2014-03-01

    To determine whether sleep spindles (SS) are potentially a biomarker for Parkinson's disease (PD). Fifteen PD patients with REM sleep behavior disorder (PD+RBD), 15 PD patients without RBD (PD-RBD), 15 idiopathic RBD (iRBD) patients and 15 age-matched controls underwent polysomnography (PSG). SS were scored in an extract of data from control subjects. An automatic SS detector using a Matching Pursuit (MP) algorithm and a Support Vector Machine (SVM) was developed and applied to the PSG recordings. The SS densities in N1, N2, N3, all NREM combined and REM sleep were obtained and evaluated across the groups. The SS detector achieved a sensitivity of 84.7% and a specificity of 84.5%. At a significance level of α=1%, the iRBD and PD+RBD patients had a significantly lower SS density than the control group in N2, N3 and all NREM stages combined. At a significance level of α=5%, PD-RBD had a significantly lower SS density in N2 and all NREM stages combined. The lower SS density suggests involvement in pre-thalamic fibers involved in SS generation. SS density is a potential early PD biomarker. It is likely that an automatic SS detector could be a supportive diagnostic tool in the evaluation of iRBD and PD patients. Copyright © 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  7. Do non-gaussian effects decrease tunneling probabilities? Three-loop instanton density for the double-well potential

    International Nuclear Information System (INIS)

    Olejnik, S.

    1989-01-01

    It is shown that the leading and next-to-leading non-gaussian effects have a minor inlfuence on the instanton density for the double-well potential: it is slightly increased, contrary to the claims of other authors. We point out a connection to recent quantitative studies of topological effects in gauge theories. (orig.)

  8. A lack of crowding? Body size does not decrease with density for two behavior-manipulating parasites

    Science.gov (United States)

    Weinersmith, KL; Warinner, Chloe B.; Tan, Virgina; Harris, David J.; Mora, Adrienne B.; Kuris, Armand M.; Lafferty, Kevin D.; Hechinger, Ryan F.

    2014-01-01

    For trophically transmitted parasites that manipulate the phenotype of their hosts, whether the parasites do or do not experience resource competition depends on such factors as the size of the parasites relative to their hosts, the intensity of infection, the extent to which parasites share the cost of defending against the host’s immune system or manipulating their host, and the extent to which parasites share transmission goals. Despite theoretical expectations for situations in which either no, or positive, or negative density-dependence should be observed, most studies document only negative density-dependence for trophically transmitted parasites. However, this trend may be an artifact of most studies having focused on systems in which parasites are large relative to their hosts. Yet, systems are common where parasites are small relative to their hosts, and these trophically transmitted parasites may be less likely to experience resource limitation. We looked for signs of density-dependence in Euhaplorchis californiensis (EUHA) and Renicola buchanani (RENB), two manipulative trematode parasites infecting wild-caught California killifish (Fundulus parvipinnis). These parasites are small relative to killifish (suggesting resources are not limiting), and are associated with changes in killifish behavior that are dependent on parasite-intensity and that increase predation rates by the parasites’ shared final host (indicating the possibility for cost sharing). We did not observe negative density-dependence in either species, indicating that resources are not limiting. In fact, observed patterns indicate possible mild positive density-dependence for EUHA. Although experimental confirmation is required, our findings suggest that some behavior-manipulating parasites suffer no reduction in size, and may even benefit when "crowded" by conspecifics.

  9. Association of pioglitazone treatment with decreased bone mineral density in obese premenopausal patients with polycystic ovary syndrome: a randomized, placebo-controlled trial

    DEFF Research Database (Denmark)

    Glintborg, D.; Andersen, Mikael; Hagen, C.

    2008-01-01

    OBJECTIVE: Our objective was to investigate the effect of pioglitazone on bone mineral density (BMD) and bone turnover markers in polycystic ovary syndrome (PCOS). DESIGN AND SETTING: We conducted a randomized, placebo-controlled study at an outpatient clinic at a university hospital. PATIENTS......, sex hormones, and body composition. CONCLUSION: Pioglitazone treatment was followed by decreased lumbar and hip BMD and decreased measures of bone turnover in a premenopausal study population relatively protected from bone mineral loss Udgivelsesdato: 2008/5...

  10. Fluoxetine protects against methamphetamine‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats.

    Science.gov (United States)

    Wang, Yun; Gu, Yu-Han; Liu, Ming; Bai, Yang; Wang, Huai-Liang

    2017-02-01

    Methamphetamine (MA) abuse is a major public health and safety concern throughout the world and a growing burden on healthcare costs. The purpose of the present study was to investigate the protective effect of fluoxetine against MA‑induced chronic pulmonary inflammation and to evaluate the potential role of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidative stress. Wistar rats were divided into control, MA and two fluoxetine‑treated groups. Rats in the MA and the two fluoxetine‑treated groups were treated daily with intraperitoneal injection of 10 mg/kg MA twice daily. Rats in the two fluoxetine‑treated groups were injected intragastrically with fluoxetine (2 and 10 mg/kg) once daily, respectively. After 5 weeks, the rats were euthanized and hematoxylin and eosin staining, immunohistochemistry, western blot analysis and redox assay were performed. It was demonstrated that chronic exposure to MA can induce pulmonary inflammation in rats, with the symptoms of inflammatory cell infiltration, crowded lung parenchyma, thickened septum and a reduced number of alveolar sacs. Fluoxetine attenuated pulmonary inflammation and the expression of interleukin‑6 and tumor necrosis factor‑α in rat lungs. Fluoxetine inhibited MA‑induced increases in the expression levels of serotonin transporter (SERT) and p‑p38 mitogen‑activated protein kinase (MAPK), and reversed the MA‑induced decrease in nuclear Nrf2 and human heme oxygenase‑1 in lungs. Fluoxetine at 10 mg/kg significantly reversed the reduced glutathione (GSH) level, the ratio of GSH/oxidized glutathione, and the reactive oxygen species level in rat lungs from the MA group. These findings suggested that fluoxetine, a SERT inhibitor, has a protective effect against MA‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats.

  11. Increased population density of neurosurgeons associated with decreased risk of death from motor vehicle accidents in the United States.

    Science.gov (United States)

    Desai, Atman; Bekelis, Kimon; Zhao, Wenyan; Ball, Perry A

    2012-09-01

    Motor vehicle accidents (MVAs) are a leading cause of death and disability in young people. Given that a major cause of death from MVAs is traumatic brain injury, and neurosurgeons hold special expertise in this area relative to other members of a trauma team, the authors hypothesized that neurosurgeon population density would be related to reduced mortality from MVAs across US counties. The Area Resource File (2009-2010), a national health resource information database, was retrospectively analyzed. The primary outcome variable was the 3-year (2004-2006) average in MVA deaths per million population for each county. The primary independent variable was the density of neurosurgeons per million population in the year 2006. Multiple regression analysis was performed, adjusting for population density of general practitioners, urbanicity of the county, and socioeconomic status of the county. The median number of annual MVA deaths per million population, in the 3141 counties analyzed, was 226 (interquartile range [IQR] 151-323). The median number of neurosurgeons per million population was 0 (IQR 0-0), while the median number of general practitioners per million population was 274 (IQR 175-410). Using an unadjusted analysis, each increase of 1 neurosurgeon per million population was associated with 1.90 fewer MVA deaths per million population (p neurosurgeon per million population was associated with 1.01 fewer MVA deaths per million population (p neurosurgeons is associated with a significant reduction in deaths from MVAs, a major cause of death nationally. This suggests that the availability of local neurosurgeons is an important factor in the overall likelihood of survival from an MVA, and therefore indicates the importance of promoting neurosurgical education and practice throughout the country.

  12. Decreased sleep spindle density in patients with idiopathic REM sleep behavior disorder and patients with Parkinson’s disease

    DEFF Research Database (Denmark)

    Christensen, Julie Anja Engelhard; Kempfner, Jacob; Zoetmulder, Marielle

    2014-01-01

    ObjectiveTo determine whether sleep spindles (SS) are potentially a biomarker for Parkinson’s disease (PD). MethodsFifteen PD patients with REM sleep behavior disorder (PD+RBD), 15 PD patients without RBD (PD−RBD), 15 idiopathic RBD (iRBD) patients and 15 age-matched controls underwent...... polysomnography (PSG). SS were scored in an extract of data from control subjects. An automatic SS detector using a Matching Pursuit (MP) algorithm and a Support Vector Machine (SVM) was developed and applied to the PSG recordings. The SS densities in N1, N2, N3, all NREM combined and REM sleep were obtained...

  13. Reduced energy density of close-up diets decrease ruminal pH and increase concentration of volatile fatty acids postpartum in Holstein cows.

    Science.gov (United States)

    Huang, Wenming; Tian, Yujia; Li, Shengli; Wu, Zhaohai; Cao, Zhijun

    2017-11-01

    The objective of this study was to determine the effect of reduced energy density of close-up diets on ruminal fermentation parameters in transition cows. Fourteen Holstein dry cows were blocked and assigned randomly to three groups fed a high energy density diet (HD, 1.62 Mcal of net energy for lactation (NE L )/kg dry matter (DM)), or a middle energy density diet (MD, 1.47 Mcal NE L /kg DM), or a low energy density diet (LD, 1.30 Mcal NE L /kg DM) prepartum, and were fed the same diet postpartum. The reduced energy density diets decreased the average dry matter intake (DMI) prepartum and tended to increase the DMI postpartum. The ruminal pH of the LD group was significantly higher prepartum and lower during the first week of lactation compared with the other two groups. The reduced energy density diet depressed the average ruminal concentration of propionate and butyrate prepartum, and increased the average concentration of total volatile fatty acids (VFA) postpartum. The LD group had higher populations of Butyrivibrio fibrisolvens and Ruminococcus flavefaciens relative to HD and MD groups on 7 days in milk. In conclusion, the cows fed reduced energy density diet prepartum had higher VFA concentration, but were more susceptible to subacute ruminal acidosis postpartum. © 2017 Japanese Society of Animal Science.

  14. Increased serum cartilage oligomeric matrix protein levels and decreased patellar bone mineral density in patients with chondromalacia patellae.

    Science.gov (United States)

    Murphy, E; FitzGerald, O; Saxne, T; Bresnihan, B

    2002-11-01

    Chondromalacia patellae is a potentially disabling disorder characterised by features of patellar cartilage degradation. To evaluate markers of cartilage and bone turnover in patients with chondromalacia patellae. 18 patients with chondromalacia patellae were studied. Serum cartilage oligomeric matrix protein (s-COMP) and bone sialoprotein (s-BSP) levels were measured by enzyme linked immunosorbent assay (ELISA) and compared with those of age and sex matched healthy control subjects. Periarticular bone mineral density (BMD) of both knee joints was assessed by dual energy x ray absorptiometry (DXA). s-COMP levels were significantly raised in all patients with chondromalacia patellae compared with healthy control subjects (p=0.0001). s-BSP levels did not differ significantly between the groups (p=0.41). BMD of the patella was significantly reduced in patients with chondromalacia patellae compared with the control subjects (p=0.016). In patients with bilateral chondromalacia patellae, BMD of the patella was lower in the more symptomatic knee joint (p=0.005). Changes in periarticular BMD were localised to the patella and were not present in femoral regions. Neither s-COMP (p=0.18) nor s-BSP (p=0.40) levels correlated with patellar BMD. Increased s-COMP levels, reflecting cartilage degradation, and reduced BMD localised to the patella may represent clinically useful markers in the diagnosis and monitoring of patients with chondromalacia patellae. Measures of cartilage degradation did not correlate with loss of patellar bone density, suggesting dissociated pathophysiological mechanisms.

  15. Computational approaches for the study of serotonin and its membrane transporter SERT: implications for drug design in neurological sciences.

    Science.gov (United States)

    Pratuangdejkul, J; Schneider, B; Launay, J-M; Kellermann, O; Manivet, P

    2008-01-01

    Serotonin (5-hydroxytryptamine, 5-HT), a monoamine neurotransmitter of the central nervous and peripheral systems (CNS), plays a critical role in a wide variety of physiological and behavioral processes. In the serotonergic system, deregulation of the tightly controlled extracellular concentration of 5-HT appears to be at the origin of a host of metabolic and psychiatric disorders. A key step that regulates 5-HT external level is the re-uptake of 5-HT into cells by the 5-HT transporter (SERT), which is besides the target of numerous drugs interacting with the serotonergic system. Therapeutic strategies have mainly focused on the development of compounds that block the activity of SERT, for instance reuptake inhibitors (e.g. tricyclics, "selective" serotonin reuptake inhibitors) and in the past, specific substrate-type releasers (e.g. amphetamine and cocaine derivatives). Today, generation of new drugs targetting SERT with enhanced selectivity and reduced toxicity is one of the most challenging tasks in drug design. In this context, studies aiming at characterizing the physicochemical properties of 5-HT as well as the biological active conformation of SERT are a prerequisite to the design of new leads. However, the absence of a high-resolution 3D-structure for SERT has hampered the design of new transporter inhibitors. Using computational approaches, numerous efforts were made to shed light on the structure of 5-HT and its transporter. In this review, we compared several in silico methods dedicated to the modeling of 5-HT and SERT with an emphasis on i) quantum chemistry for study of 5-HT conformation and ii) ligand-based (QSAR and pharmacophore models) and transporter-based (homology models) approaches for studying SERT molecule. In addition, we discuss some methodological aspects of the computational work in connection with the construction of putative but reliable 3D structural models of SERT that may help to predict the mechanisms of neurotransmitter transport.

  16. One-step preparation of [18F]FPBM for PET imaging of serotonin transporter (SERT) in the brain

    International Nuclear Information System (INIS)

    Qiao, Hongwen; Zhang, Yan; Wu, Zehui; Zhu, Lin; Choi, Seok Rye; Ploessl, Karl; Kung, Hank F.

    2016-01-01

    Serotonin transporters (SERT) in the brain play an important role in normal brain function. Selective serotonin reuptake inhibitors such as fluoxetine, sertraline, paroxetine, escitalopram, etc., specifically target SERT binding in the brain. Development of SERT imaging agents may be useful for studying the function of SERT by in vivo imaging. A one-step preparation of [ 18 F]FPBM, 2-(2′-(dimethylamino)methyl)-4′-(3-([ 18 F]fluoropropoxy)phenylthio) benzenamine, for positron emission tomography (PET) imaging of SERT binding in the brain was achieved. An active OTs intermediate, 9, was reacted with [ 18 F]F − /K 222 to produce [ 18 F]FPBM in one step and in high radiochemical yield. This labeling reaction was evaluated and optimized under different temperatures, bases, solvents, and varying amounts of precursor 9. The radiolabeling reaction led to the desired [ 18 F]FPBM in one step and the crude product was purified by HPLC purification to give no-carrier-added [ 18 F]FPBM (radiochemical yield, 24–33%, decay corrected; radiochemical purity > 99%). PET imaging studies in normal monkeys (n = 4) showed fast, pronounced uptakes in the midbrain and thalamus, regions known to be rich in SERT binding sites. A displacement experiment with escitalopram (5 mg/kg iv injection at 30 min after [ 18 F]FPBM injection) showed a rapid and complete reversal of SERT binding, suggesting that binding by [ 18 F]FPBM was highly specific and reversible. A one-step radiolabeling method coupled with HPLC purification for preparation of [ 18 F]FPBM was developed. Imaging studies suggest that it is feasible to use this method to prepare [ 18 F]FPBM for in vivo PET imaging of SERT binding in the brain.

  17. Density control of electrodeposited Ni nanoparticles/nanowires inside porous anodic alumina templates by an exponential anodization voltage decrease.

    Science.gov (United States)

    Marquardt, B; Eude, L; Gowtham, M; Cho, G; Jeong, H J; Châtelet, M; Cojocaru, C S; Kim, B S; Pribat, D

    2008-10-08

    Porous alumina templates have been fabricated by applying an exponential voltage decrease at the end of the anodization process. The time constant η of the exponential voltage function has been used to control the average thickness and the thickness distribution of the barrier layer at the bottom of the pores of the alumina structure. Depending on the η value, the thickness distribution of the barrier layer can be made very uniform or highly scattered, which allows us to subsequently fine tune the electrodeposition yield of nickel nanoparticles/nanowires at low voltage. As an illustration, the pore filling percentage with Ni has been varied, in a totally reproducible manner, between ∼3 and 100%. Combined with the ability to vary the pore diameter and repetition step over ∼2 orders of magnitude (by varying the anodization voltage and electrolyte type), the control of the pore filling percentage with metal particles/nanowires could bring novel approaches for the organization of nano-objects.

  18. Decreased Staphylococcus aureus and increased osteoblast density on nanostructured electrophoretic-deposited hydroxyapatite on titanium without the use of pharmaceuticals.

    Science.gov (United States)

    Mathew, Dennis; Bhardwaj, Garima; Wang, Qi; Sun, Linlin; Ercan, Batur; Geetha, Manisavagam; Webster, Thomas J

    2014-01-01

    Plasma-spray deposition of hydroxyapatite on titanium (Ti) has proven to be a suboptimal solution to improve orthopedic-implant success rates, as demonstrated by the increasing number of orthopedic revision surgeries due to infection, implant loosening, and a myriad of other reasons. This could be in part due to the high heat involved during plasma-spray deposition, which significantly increases hydroxyapatite crystal growth into the nonbiologically inspired micron regime. There has been a push to create nanotopographies on implant surfaces to mimic the physiological nanostructure of native bone and, thus, improve osteoblast (bone-forming cell) functions and inhibit bacteria functions. Among the several techniques that have been adopted to develop nanocoatings, electrophoretic deposition (EPD) is an attractive, versatile, and effective material-processing technique. The in vitro study reported here aimed to determine for the first time bacteria responses to hydroxyapatite coated on Ti via EPD. There were six and three times more osteoblasts on the electrophoretic-deposited hydroxyapatite on Ti compared with Ti (control) and plasma-spray-deposited hydroxyapatite on Ti after 5 days of culture, respectively. Impressively, there were 2.9 and 31.7 times less Staphylococcus aureus on electrophoretic-deposited hydroxyapatite on Ti compared with Ti (control) and plasma-spray-deposited hydroxyapatite on Ti after 18 hours of culture, respectively. Compared with uncoated Ti and plasma-sprayed hydroxyapatite coated on Ti, the results provided significant promise for the use of EPD to improve bone-cell density and be used as an antibacterial coating without resorting to the use of antibiotics.

  19. Early increase and late decrease of purkinje cell dendritic spine density in prion-infected organotypic mouse cerebellar cultures.

    Science.gov (United States)

    Campeau, Jody L; Wu, Gengshu; Bell, John R; Rasmussen, Jay; Sim, Valerie L

    2013-01-01

    Prion diseases are infectious neurodegenerative diseases associated with the accumulation of protease-resistant prion protein, neuronal loss, spongiform change and astrogliosis. In the mouse model, the loss of dendritic spines is one of the earliest pathological changes observed in vivo, occurring 4-5 weeks after the first detection of protease-resistant prion protein in the brain. While there are cell culture models of prion infection, most do not recapitulate the neuropathology seen in vivo. Only the recently developed prion organotypic slice culture assay has been reported to undergo neuronal loss and the development of some aspects of prion pathology, namely small vacuolar degeneration and tubulovesicular bodies. Given the rapid replication of prions in this system, with protease-resistant prion protein detectable by 21 days, we investigated whether the dendritic spine loss and altered dendritic morphology seen in prion disease might also develop within the lifetime of this culture system. Indeed, six weeks after first detection of protease-resistant prion protein in tga20 mouse cerebellar slice cultures infected with RML prion strain, we found a statistically significant loss of Purkinje cell dendritic spines and altered dendritic morphology in infected cultures, analogous to that seen in vivo. In addition, we found a transient but statistically significant increase in Purkinje cell dendritic spine density during infection, at the time when protease-resistant prion protein was first detectable in culture. Our findings support the use of this slice culture system as one which recapitulates prion disease pathology and one which may facilitate study of the earliest stages of prion disease pathogenesis.

  20. Prevalence and risk factors associated with goat gastrointestinal helminthiasis in the Sertão region of Paraíba State, Brazil.

    Science.gov (United States)

    Vieira, Vanessa Diniz; Feitosa, Thais Ferreira; Vilela, Vinícius Longo Ribeiro; Azevedo, Sérgio Santos; de Almeida Neto, João Leite; de Morais, Dayana Firmino; Ribeiro, Ana Raquel Carneiro; Athayde, Ana Célia Rodrigues

    2014-02-01

    Gastrointestinal helminthiasis represents an obstacle to goat raising, causing severe damage to herds such as growth retardation, weight loss, and even death. In this study, we aimed to determine the prevalence and risk factors associated to goat gastrointestinal helminthiasis in the Sertão region of Paraíba State, Brazil. A total of 256 goats from 54 farms were systematically sampled. Blood and fecal samples were collected from each animal for egg per gram (EPG), larval culture, and packed cell volume (PCV) analyses. We found that 79.3% of the goats investigated were parasitized with gastrointestinal helminths. Significant correlation (p = 0.004) was observed between the EPG and PCV of the animals studied, and it was observed that the EPG increases as the PCV decreases. In the larval culture, the most prevalent helminth was Haemonchus sp. (83.2%). Age and sex were significant variables (p ≤ 0.20) for the development of gastrointestinal helminths: 86.8% of animals over 36 months of age and 81.7% of females were infected. The variable type of animal exploitation was also significant, with 90.3% (p ≤ 0.20) of the animals presenting double suitability (milk and meat). The Sertão region of Paraíba State presents high prevalence of gastrointestinal helminthiasis in goats, and age and type of animal exploitation are the most relevant risk factors to the development of these parasites.

  1. Sevelamer does not decrease lipopolysaccharide or soluble CD14 levels but decreases soluble tissue factor, low-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol levels in individuals with untreated HIV infection.

    Science.gov (United States)

    Sandler, Netanya G; Zhang, Xinyan; Bosch, Ronald J; Funderburg, Nicholas T; Choi, Andrew I; Robinson, Janet K; Fine, Derek M; Coombs, Robert W; Jacobson, Jeffrey M; Landay, Alan L; Douek, Daniel C; Tressler, Randall; Read, Sarah W; Wilson, Cara C; Deeks, Steven G; Lederman, Michael M; Gandhi, Rajesh T

    2014-11-15

    Abnormal levels of inflammation are associated with cardiovascular disease and mortality in human immunodeficiency virus (HIV)-infected patients. Microbial translocation, which may cause inflammation, is decreased by sevelamer in patients undergoing hemodialysis. In this single-arm study, we evaluated the effects of 8 weeks of sevelamer therapy on 36 HIV-infected subjects who were not receiving antiretroviral therapy. Sevelamer did not significantly change markers of microbial translocation, inflammation, or T-cell activation. During sevelamer treatment, however, levels of soluble tissue factor, low-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol decreased significantly, whereas D-dimer levels increased. Thus, in this study population, sevelamer did not reduce microbial translocation but may have yielded cardiovascular benefits. NCT 01543958. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  2. Histórico genético e populacional do rebanho Nelore Puro de Origem no Sertão Nordestino Genetic and populational background of Pure Nelore cattle breed in Brazilian Northeastern Sertão

    Directory of Open Access Journals (Sweden)

    Carlos Henrique Mendes Malhado

    2009-07-01

    Full Text Available O objetivo deste trabalho foi avaliar o histórico do rebanho Nelore Puro de Origem no Sertão Nordestino por meio da determinação de sua estrutura populacional e da quantificação do progresso genético, fenotípico e ambiental ocorrido em características de desenvolvimento ponderal. Foram utilizadas informações de pedigree de animais nascidos no período de 1964 a 2006 e dados das massas corporais ajustadas aos 205 e 365 dias de idade de bovinos nascidos de 1978 a 2006. O pequeno número de ancestrais explicou a baixa variabilidade genética e os reduzidos valores dos coeficientes de herdabilidade observados para as características de crescimento. O coeficiente de endogamia média e a percentagem de animais endogâmicos na população aumentaram no decorrer das gerações. Contudo, o coeficiente de endogamia médio dos animais endogâmicos diminuiu, o que é indicativo de que os acasalamentos entre parentes próximos estão sendo evitados. O tamanho efetivo da população oscilou de 100 a 200 animais em quase todo o período estudado. Não se constatou ganho genético no período. Contudo, a raça obteve um considerável ganho fenotípico ocasionado por melhorias ambientais.The objective of this study was to evaluate the Pure Nelore cattle breed background in the Brazilian Northeastern Sertão region by determining its population structure and quantifying genetic, phenotypic and environmental progress based on ponderal development traits. Pedigree data of animals born between 1964 and 2006 and weight values, adjusted to 205 and 365 days of age, of bovines born between 1978 and 2006 were used. The small number of ancestors explained the population's low genetic variability and the reduced heritability coefficient values observed for growth traits. The mean inbreeding coefficient and the percentage of endogamic animals within the population increased over the generations. However, the mean inbreeding coefficient of endogamic animals

  3. O sertão amazônico: o inferno de Alberto Rangel The amazonian sertão: the hell of Alberto Rangel

    Directory of Open Access Journals (Sweden)

    Marco Aurélio Coelho de Paiva

    2011-01-01

    Full Text Available A partir da análise do livro de estreia de Alberto Rangel, Inferno verde, publicado em 1908, o artigo busca identificar as motivações e os constrangimentos presentes no processo criativo do autor quanto à formulação de uma representação da Amazônia como sertão. A sua filiação ao estilo de Euclides da Cunha e a sua vinculação ao aparato administrativo estatal quando da sua presença na região confluíram para uma ideia de região então assentada em seu aspecto infernista. O entendimento da realidade nacional a partir dos sertões fez com que a Amazônia fosse tomada pelo autor como um mundo relegado ao esquecimento. Uma interpretação dos diferentes contos do livro e a identificação de uma representação infernista da Amazônia só poderão ser logradas caso leve-se em consideração os aspectos vinculados aos anseios e angústias de Alberto Rangel em tornar-se um escritor e ser reconhecido como tal.Based on the book debut of Alberto Rangel, Inferno Verde (Green Hell, published in 1908, this article investigates the motivations and constraints present in the author's creative process, regarding the representation of the Amazon as sertão (backlands. His adherence to the style of Euclides da Cunha, and his relationship with the state administrative apparatus when he was in the region, contributed to the idea of what seemed to be a hellish aspect of the Amazon. In his understanding of the national reality, in relation to the backlands, the author saw the Amazon as a forgotten world. For a different interpretation of the stories in the book, and the recognition of this hellish representation of the Amazon, it is necessary to take into consideration the aspects related to the aspirations and anxieties of Alberto Rangel on becoming a writer and to be recognized as such.

  4. Decrease in local volumetric bone mineral density (vBMD) in osteoarthritic joints is associated with the increase in cartilage damage: a pQCT study

    Science.gov (United States)

    Tamaddon, Maryam; Chen, Shen Mao; Vanaclocha, Leyre; Hart, Alister; El-Husseiny, Moataz; Henckel, Johann; Liu, Chaozong

    2017-11-01

    Osteoarthritis (OA) is the most common type of arthritis and a major cause of disability in the adult population. It affects both cartilage and subchondral bone in the joints. There has been some progress in understanding the changes in subchondral bone with progression of osteoarthritis. However, local changes in subchondral bone such as microstructure or volumetric bone mineral density in connection with the defect in cartilage are relatively unexplored. To develop an effective treatment for progression of OA, it is important to understand how the physical environment provided by the subchondral bone affects the overlying cartilage. In this study we examined the volumetric bone mineral density (vBMD) distribution in the osteoarthritic joint tissues obtained from total hip replacement surgeries due to osteoarthritis, using peripheral quantitative CT (pQCT). It was found that there is a significant decrease in volumetric bone mineral density, which co-localises with the damage in the overlying cartilage. This was not limited to the subchondral bone immediately adjacent to the cartilage defect but continued in the layers below. Bone resorption and cyst formation in the OA tissues were also detected. We observed that the bone surrounding subchondral bone cysts exhibited much higher volumetric bone mineral density than that of the surrounding bones. PQCT was able to detect significant changes in vBMD between OA and non-OA samples, as well as between areas of different cartilage degeneration, which points to its potential as a technique for detection of early OA.

  5. DAT/SERT Selectivity of Flexible GBR 12909 Analogs Modeled Using 3D-QSAR Methods

    Science.gov (United States)

    Gilbert, Kathleen M.; Boos, Terrence L.; Dersch, Christina M.; Greiner, Elisabeth; Jacobson, Arthur E.; Lewis, David; Matecka, Dorota; Prisinzano, Thomas E.; Zhang, Ying; Rothman, Richard B.; Rice, Kenner C.; Venanzi, Carol A.

    2007-01-01

    The dopamine reuptake inhibitor GBR 12909 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine, 1) and its analogs have been developed as tools to test the hypothesis that selective dopamine transporter (DAT) inhibitors will be useful therapeutics for cocaine addiction. This 3D-QSAR study focuses on the effect of substitutions in the phenylpropyl region of 1. CoMFA and CoMSIA techniques were used to determine a predictive and stable model for the DAT/serotonin transporter (SERT) selectivity (represented by pKi (DAT/SERT)) of a set of flexible analogs of 1, most of which have eight rotatable bonds. In the absence of a rigid analog to use as a 3D-QSAR template, six conformational families of analogs were constructed from six pairs of piperazine and piperidine template conformers identified by hierarchical clustering as representative molecular conformations. Three models stable to y-value scrambling were identified after a comprehensive CoMFA and CoMSIA survey with Region Focusing. Test set correlation validation led to an acceptable model, with q2 = 0.508, standard error of prediction = 0.601, two components, r2 = 0.685, standard error of estimate = 0.481, F value = 39, percent steric contribution = 65, and percent electrostatic contribution = 35. A CoMFA contour map identified areas of the molecule that affect pKi (DAT/SERT). This work outlines a protocol for deriving a stable and predictive model of the biological activity of a set of very flexible molecules. PMID:17127069

  6. Os antigos germanos em Os Sertões: Canudos e Teutoburgo

    Directory of Open Access Journals (Sweden)

    Rafael Vicente Kunst

    2016-06-01

    Full Text Available Para explicar a aparente contradição entre barbárie e civilização que envolvia a descrição do sertanejo ao longo de Os Sertões, Euclides da Cunha recorre a diversos elementos da Antiguidade clássica como, por exemplo, a narrativa da batalha de Teutoburgo. Minha pesquisa consiste em analisar como e com quais motivações a escrita euclidiana utiliza as descrições clássicas dos antigos povos germânicos e seus conflitos contra os romanos.

  7. Decrease in plasma high-density lipoprotein cholesterol levels at puberty in boys with delayed adolescence: correlation with plasma testosterone levels

    International Nuclear Information System (INIS)

    Kirkland, R.T.; Keenan, B.S.; Probstfield, J.L.; Patsch, W.; Lin, T.L.; Clayton, G.W.; Insull, W. Jr.

    1987-01-01

    A three-phase study tested the hypothesis that the decrease in the high-density lipoprotein cholesterol (HDL-C) level observed in boys at puberty is related to an increase in the plasma testosterone concentration. In phase I, 57 boys aged 10 to 17 years were categorized into four pubertal stages based on clinical parameters and plasma testosterone levels. These four groups showed increasing plasma testosterone values and decreasing HDL-C levels. In phase II, 14 boys with delayed adolescence were treated with testosterone enanthate. Plasma testosterone levels during therapy were in the adult male range. Levels of HDL-C decreased by a mean of 7.4 mg/dL (0.20 mmol/L) and 13.7 mg/dL (0.35 mmol/L), respectively, after the first two doses. In phase III, 13 boys with delayed adolescence demonstrated increasing plasma testosterone levels and decreasing HDL-C levels during spontaneous puberty. Levels of HDL-C and apolipoprotein A-1 were correlated during induced and spontaneous puberty. Testosterone should be considered a significant determinant of plasma HDL-C levels during pubertal development

  8. Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose-Derived Multipotent Mesenchymal Stem Cells In Vitro, and Increases Bone Density In Vivo

    Directory of Open Access Journals (Sweden)

    Krzysztof Marycz

    2016-01-01

    Full Text Available Due to its pleiotropic effects, the commonly used drug metformin has gained renewed interest among medical researchers. While metformin is mainly used for the treatment of diabetes, recent studies suggest that it may have further application in anticancer and antiaging therapies. In this study, we investigated the proliferative potential, accumulation of oxidative stress factors, and osteogenic and adipogenic differentiation potential of mouse adipose-derived stem cells (MuASCs isolated from mice treated with metformin for 8 weeks. Moreover, we investigated the influence of metformin supplementation on mice bone density and bone element composition. The ASCs isolated from mice who were treated with metformin for 8 weeks showed highest proliferative potential, generated a robust net of cytoskeletal projections, had reduced expression of markers associated with cellular senescence, and decreased amount of reactive oxygen species in comparison to control group. Furthermore, we demonstrated that these cells possessed greatest osteogenic differentiation potential, while their adipogenic differentiation ability was reduced. We also demonstrated that metformin supplementation increases bone density in vivo. Our result stands as a valuable source of data regarding the in vivo influence of metformin on ASCs and bone density and supports a role for metformin in regenerative medicine.

  9. Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: a study in SERT knockout rats.

    NARCIS (Netherlands)

    Olivier, J.; Cools, A.R.; Olivier, B.; Homberg, J.R.; Cuppen, E.; Ellenbroek, B.A.

    2008-01-01

    Disturbances in the serotonergic system are implicated in many central nervous system disorders. The serotonin transporter (SERT) regulates the serotonin homeostasis in the synapse. We recently developed a rat which lacks the serotonin transporter (SERT(-/-)). It is likely that adaptive changes take

  10. Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations : a study in SERT knockout rats

    NARCIS (Netherlands)

    Olivier, Jocelien D A; Cools, Alexander R; Olivier, Berend; Homberg, Judith R; Cuppen, Edwin; Ellenbroek, Bart A

    2008-01-01

    Disturbances in the serotonergic system are implicated in many central nervous system disorders. The serotonin transporter (SERT) regulates the serotonin homeostasis in the synapse. We recently developed a rat which lacks the serotonin transporter (SERT(-/-)). It is likely that adaptive changes take

  11. Small high-density lipoprotein (HDL) subclasses are increased with decreased activity of HDL-associated phospholipase A₂ in subjects with prediabetes.

    Science.gov (United States)

    Filippatos, Theodosios D; Rizos, Evangelos C; Tsimihodimos, Vasilios; Gazi, Irene F; Tselepis, Alexandros D; Elisaf, Moses S

    2013-06-01

    Alterations in high-density lipoprotein (HDL) subclass distribution, as well as in the activities of HDL-associated enzymes, have been associated with increased cardiovascular disease (CVD) risk. HDL subclass distribution and the activities of HDL-associated enzymes remain unknown in prediabetic patients, a condition also associated with increased CVD risk. The aim of the present study was to assess any differences in HDL subclass distribution (using polyacrylamide gel electrophoresis) and in activities of HDL-associated enzymes between prediabetic (impaired fasting glucose, IFG, n = 80) and non-prediabetic subjects (n = 105). Subjects with prediabetes had significantly increased waist circumference, blood pressure and triacylglycerol (TAG) levels compared with subjects with fasting glucose levels prediabetic subjects compared with their controls (p prediabetes (p prediabetes. In a stepwise linear regression analysis, the proportion of small HDL3 over HDL-C concentration was independently associated with the presence of prediabetes and with total cholesterol and TAG concentration (positively), as well as with HDL-C levels (negatively). We also observed a trend of increased small dense low-density lipoprotein cholesterol levels in prediabetic subjects compared with their controls. Subjects with IFG exhibit increased proportion of small HDL3 particles combined with decreased activity of the anti-atherogenic HDL-LpPLA₂.

  12. Os sertões: atualidade e arcaísmo na representação cultural de um conflito brasileiro Os sertões: present time and archaism in the cultural representation of a Brazilian conflict

    Directory of Open Access Journals (Sweden)

    Paulo Venancio Filho

    1998-07-01

    Full Text Available Este texto busca contrapor os aspectos antagônicos da revolta de Canudos tal como percebido por Euclides da Cunha em Os sertões. A revolta revelava tragicamente a permanência de um arcaísmo irresolvido. O horror da guerra, o confronto entre a ‘civilização’ e a ‘barbárie’ ainda se manifestam cem anos depois do conflito. O mesmo confronto que a literatura já pressentia e descrevia. Aquele que, no plano não menos verdadeiro da ficção, também se revela no romance O coração das trevas, de Joseph Conrad, publicado em 1902, o mesmo ano da publicação de Os sertões.The article examines antagonistic aspects of the battle of Canudos as portrayed by Euclides da Cunha in Os sertões. In tragic fashion, the rebellion made it apparent that an archaism had not been resolved. The horror of war, the conflict between civilization and barbarism, is still with us one hundred years later - the same conflict that literature foresaw and described. In the realm of fiction (yet no less truthful, this conflict was also portrayed in Joseph Conrad’s Heart of Darkness, published in 1902, the same year as Os sertões.

  13. Índios e negros nos sertões das minas: Contatos e identidades

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    Marcel Mano

    2015-08-01

    Full Text Available O artigo busca resgatar parte da ocupação indígena e quilombola dos sertões das minas no segundo e terceiro quartos do século XVIII, com vistas a um mapeamento dos encontros e intersecções culturais entre esses dois coletivos. Com base na perspectiva antropológica da alteridade é realizada a análise de uma documentação histórica disponível para os atuais oeste de Minas Gerais, Triângulo Mineiro e sul de Goiás, que permite propor que as culturas e identidades coletivas de “gentios” e “calhambolas” estivessem se reelaborando num contexto de negociações e conflitos entre diferentes sujeitos históricos.

  14. Tristeza parasitária bovina no Sertão da Paraíba

    Directory of Open Access Journals (Sweden)

    V.M.M. Costa

    2011-03-01

    Full Text Available Descrevem-se 24 surtos de tristeza parasitária bovina no sertão paraibano, sendo 18 de anaplasmose por Anaplasma margimale, dois de babesiose por Babesia bigemina, dois por Babesia não identificada e dois por infecção mista de A. marginale e Babesia sp. Os surtos ocorreram entre agosto de 2007 a outubro de 2009, porém, com uma concentração dos surtos no final do período chuvoso e início do período seco de cada ano, sendo 22 em animais adultos e dois em bezerros de aproximadamente 11 meses. Dois surtos ocorreram em bovinos da raça Nelore, um em animais da raça Gir e os 21 restantes ocorreram em animais das raças Holandês, Pardo Suiço e mestiços das mesmas com zebuínos. Conclui-se que no sertão da Paraíba há áreas de instabilidade enzoótica, ocorrendo surtos de tristeza no final da época de chuvas, principalmente nas áreas de planaltos e serras da região da Borborema e em áreas úmidas como a Bacia do Rio do Peixe, Rio Piranhas e Rio Espinharas em que há a formação de microclimas favoráveis à sobrevivência do carrapato.

  15. Classificação de solos planossólicos do Sertão do Araripe (PE Classification of planossolic soils from the Sertão do Araripe region, of State Pernambuco, Brazil

    Directory of Open Access Journals (Sweden)

    L. B. Oliveira

    2003-08-01

    , desde que apresente transição abrupta que configure um fraturamento muito nítido com o horizonte que o antecede (A, E ou Bt.Soils with a planic B horizon underlying a textural B horizon and, therefore, not regarded as Planosols in the Brazilian System of Soil Classification (SIBCS were characterized and classified. Three representative soil profiles were selected in the county of Ouricuri, Araripina micro-region, within the Sertão Zone of Pernambuco State, an area with a high density of planossolic soils. Soil profiles were morphologically described and disturbed samples taken from each horizon for physical and chemical analyses. Undisturbed samples were collected to determine bulk density. Results showed that the soils, formed by the contribution of two parent materials (sediments and crystalline rocks, demonstrate this double origin with two distinct sections. The top on is formed by A, BA, Bt, and/or Btf horizons, and the bottom one by 2Btbn and 2BCn horizons. The topsoil horizons have colors of higher chromas, lower clay contents, smaller bulk density, higher hydraulic conductivity, and a lower clay activity compared to the subsoil horizons, characterized by high bulk density, low chromas and very low hydraulic conductivity, limiting the downward movement of water. The soils were classified in the SIBCS as: Sodic Planossolic Eutric Argiluvic Plinthosol (profile 1; Solodic Planossolic Eutric Yellow Argisol (profile 2 and Sodic Planossolic Plinthic Eutric Yellow Argisol (profile 3. Changes in the definition of the planic B horizon were suggested to allow the inclusion of the studied soils as follows: a planic B horizon must not obligatorily underlie an A or E horizon nor present an abrupt particle size alteration as long as it presents abrupt transition that is a very clear rupture with the previous A, E or Bt horizon.

  16. Iluminista e romântico: o tempo passado em Os sertões de Euclides da Cunha Enlightened and romantic: the past in Euclides da Cunha’s Os sertões

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    Glaucia Villas Bôas

    1998-07-01

    Full Text Available O artigo discute a questão da construção da nação em Os sertões de Euclides da Cunha, mostrando como se fundamenta em uma visão ambígua do tempo passado, que o autor considera fundante da sociedade brasileira. Confrontando com a formação do Estado republicano, a instauração de uma sociedade moderna e a tradição singularíssima da cultura sertaneja, Euclides descreve na guerra de Canudos o conflito entre duas lógicas dificilmente reconciliáveis - a lógica da origem e do destino de pertencimento a uma cultura e a lógica legal, igualitária e racional própria dos tempos modernos.The question of nation building as expressed in Os sertões is based on the ambiguous views of the past held by its author. Witnessing the formation of a Republican state, the inauguration of a modern society, and the singular traditions of sertão culture, Cunha describes a conflict between two kinds of logic that are hard to reconcile: the logic of the origin of a culture and the destiny of belonging to it, on the one hand, and the legalistic, egalitarian, rational logic of modern times.

  17. Reference tissue modeling with parameter coupling: application to a study of SERT binding in HIV

    Energy Technology Data Exchange (ETDEWEB)

    Endres, Christopher J; Pomper, Martin G [Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD 21231 (United States); Hammoud, Dima A, E-mail: endres@jhmi.edu [Radiology and Imaging Sciences, National Institutes of Health/Clinical Center, Bethesda, MD (United States)

    2011-04-21

    When applicable, it is generally preferred to evaluate positron emission tomography (PET) studies using a reference tissue-based approach as that avoids the need for invasive arterial blood sampling. However, most reference tissue methods have been shown to have a bias that is dependent on the level of tracer binding, and the variability of parameter estimates may be substantially affected by noise level. In a study of serotonin transporter (SERT) binding in HIV dementia, it was determined that applying parameter coupling to the simplified reference tissue model (SRTM) reduced the variability of parameter estimates and yielded the strongest between-group significant differences in SERT binding. The use of parameter coupling makes the application of SRTM more consistent with conventional blood input models and reduces the total number of fitted parameters, thus should yield more robust parameter estimates. Here, we provide a detailed evaluation of the application of parameter constraint and parameter coupling to [{sup 11}C]DASB PET studies. Five quantitative methods, including three methods that constrain the reference tissue clearance (k{sup r}{sub 2}) to a common value across regions were applied to the clinical and simulated data to compare measurement of the tracer binding potential (BP{sub ND}). Compared with standard SRTM, either coupling of k{sup r}{sub 2} across regions or constraining k{sup r}{sub 2} to a first-pass estimate improved the sensitivity of SRTM to measuring a significant difference in BP{sub ND} between patients and controls. Parameter coupling was particularly effective in reducing the variance of parameter estimates, which was less than 50% of the variance obtained with standard SRTM. A linear approach was also improved when constraining k{sup r}{sub 2} to a first-pass estimate, although the SRTM-based methods yielded stronger significant differences when applied to the clinical study. This work shows that parameter coupling reduces the

  18. A phase I feasibility study of multi-modality imaging assessing rapid expansion of marrow fat and decreased bone mineral density in cancer patients.

    Science.gov (United States)

    Hui, Susanta K; Arentsen, Luke; Sueblinvong, Thanasak; Brown, Keenan; Bolan, Pat; Ghebre, Rahel G; Downs, Levi; Shanley, Ryan; Hansen, Karen E; Minenko, Anne G; Takhashi, Yutaka; Yagi, Masashi; Zhang, Yan; Geller, Melissa; Reynolds, Margaret; Lee, Chung K; Blaes, Anne H; Allen, Sharon; Zobel, Bruno Beomonte; Le, Chap; Froelich, Jerry; Rosen, Clifford; Yee, Douglas

    2015-04-01

    Cancer survivors are at an increased risk for fractures, but lack of effective and economical biomarkers limits quantitative assessments of marrow fat (MF), bone mineral density (BMD) and their relation in response to cytotoxic cancer treatment. We report dual energy CT (DECT) imaging, commonly used for cancer diagnosis, treatment and surveillance, as a novel biomarker of MF and BMD. We validated DECT in pre-clinical and phase I clinical trials and verified with water-fat MRI (WF-MRI), quantitative CT (QCT) and dual-energy X-ray absorptiometry (DXA). Basis material composition framework was validated using water and small-chain alcohols simulating different components of bone marrow. Histologic validation was achieved by measuring percent adipocyte in the cadaver vertebrae and compared with DECT and WF-MRI. For a phase I trial, sixteen patients with gynecologic malignancies (treated with oophorectomy, radiotherapy or chemotherapy) underwent DECT, QCT, WF-MRI and DXA before and 12months after treatment. BMD and MF percent and distribution were quantified in the lumbar vertebrae and the right femoral neck. Measured precision (3mg/cm(3)) was sufficient to distinguish test solutions. Adiposity in cadaver bone histology was highly correlated with MF measured using DECT and WF-MRI (r=0.80 and 0.77, respectively). In the clinical trial, DECT showed high overall correlation (r=0.77, 95% CI: 0.69, 0.83) with WF-MRI. MF increased significantly after treatment (p<0.002). Chemotherapy and radiation caused greater increases in MF than oophorectomy (p<0.032). L4 BMD decreased 14% by DECT, 20% by QCT, but only 5% by DXA (p<0.002 for all). At baseline, we observed a statistically significant inverse association between MF and BMD which was dramatically attenuated after treatment. Our study demonstrated that DECT, similar to WF-MRI, can accurately measure marrow adiposity. Both imaging modalities show rapid increase in MF following cancer treatment. Our results suggest that MF and

  19. Field and city: Grande Sertão and Tristes Trópicos

    Directory of Open Access Journals (Sweden)

    Abel da Silveira Viana

    2008-07-01

    Full Text Available Until what point the intellectual improvement made possible the improvement in the social relations between field and city in Brazil of 20th century middle? The articulated and displayed images by important intellectuals were many times entailed to a supposed necessity of governmental public politics directed to the field inhabitant. The constatation takes us to at least two questions: the disguise of a superficial human being construction, which is, the idea of democratic State, based in a false politics unit, social and cultural, when not racial; and, as a consequence, the subjugation of social groups kept out of society, which the field inhabitant is one example. For the evaluation of this problem, we have two basic texts, for joining a important dimension to think about the problem of the representation and state homogenization: for being central in the debate on the relation field-city, and to establish dialogue with the academic thought of its time. These workmanships, which the article talks about, are Tristes trópicos, by Claude Lévi-Strauss, and Grande sertão: veredas by João Guimarães Rosa.

  20. Grande sertão: veredas - as artimanhas da enunciação

    Directory of Open Access Journals (Sweden)

    Jeane Mari Sant'Ana Spera

    2005-10-01

    Full Text Available Responsável pela arquitetura narrativa de Grande sertão: veredas, o narrador Riobaldo conduz o  jogo dialógico de modo a criar  um vai­vém discursivo que  possibilita a detecção pontual de segmentos pertencentes à ordem do discurso e à ordem da história (respectivamente, mundo comentado e mundo narrado, segundo Harald Weinrich. Permeando um e outro mundo, estão as obsessões fundamentais do narrador, das quais destacamos aquela relativa à existência ou não do diabo. As ambiguidades derivadas desse  movimento oscilante entre o ser e o não-ser provocam ainda  o deslizamento entre o real e o irreal, o dito e o não-dito, o aparente e o oculto, o dado  e o suposto. A coerência, no entanto, é reconstituída no alinhavado constante de vários recursos argumentativos que busca m a adesão do  interlocutor, cuja voz só é entre ou vida pela voz do narrador. Nesses casos,  verificamos a presença do recurso ao argumento de autoridade, seja pela competência,  seja  pela  experiência,  seja, ainda,  pelo  testemunho. É, pois, nesses momentos de interlocução semiexplícita, na instância  da enunciação, que se apresentam, com  maior  nitidez, elementos linguísticos denunciadores das estratégias argumentativas que  provocam e incitam o interlocutor/leitor a acompanhar esse "narrar dificultoso” e a finalmente concordar que “O diabo não há!... Existe é homem  humano”.

  1. Entre Clio e Calíope: a construção da narrativa histórica em Os sertões Between Clio and Calliope: construction of the historical narrative in Os sertões

    Directory of Open Access Journals (Sweden)

    Luiz Fernando Valente

    1998-07-01

    Full Text Available Este artigo focaliza a complexa aliança entre a história e a ficção em Os sertões a partir de novas teorias sobre a textualidade da história e de novas metodologias de abordagem do texto literário, como o ‘novo historicismo’. Após uma sinopse dessas teorias e metodologias, examina os processos de construção da narrativa de Os sertões, demonstrando como o texto é marcado pela interpenetração do sistema que informa o cientista com o que rege o artista. À medida que o arcabouço intelectual e científico importado da Europa se mostra insuficiente para registrar a realidade brasileira, o texto euclidiano começa a deslizar entre a história e a ficção. A conclusão: apenas interstícios entre história e ficção Euclides consegue localizar aquela verdade que, desde a ‘Nota preliminar’, afirmava ser seu objetivo principal.The complex alliance between history and fiction found in Os sertões is examined from the perspective of new theories on the textuality of history and new methodologies in the study of literary texts, such as the so-called new historicism. After presenting a synthesis of these tools, the essay examines the construction of the narrative in Os sertões and shows how Cunha’s text is characterized by an inter-penetration of the system that informed the scientist with the system that governed the artist. As the intellectual and scientific framework imported from Europe proves inadequate in recording the Brazilian reality, Cunhas’ text begins slipping back and forth between history and fiction. In conclusion, it is argued that only in the interstices between history and fiction does Cunha manage to situate that truth which, starting right in his ‘Preliminary note’, he claimed as his prime objective.

  2. Astrocytosis measured by {sup 11}C-deprenyl PET correlates with decrease in gray matter density in the parahippocampus of prodromal Alzheimer's patients

    Energy Technology Data Exchange (ETDEWEB)

    Choo, IL Han [Karolinska Institutet, Department NVS, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Stockholm (Sweden); Chosun University, Department of Neuropsychiatry, School of Medicine, Gwangju (Korea, Republic of); Carter, Stephen F. [Karolinska Institutet, Department NVS, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Stockholm (Sweden); Manchester University, Wolfson Imaging Center, Manchester (United Kingdom); Schoell, Michael L. [Karolinska Institutet, Department NVS, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Stockholm (Sweden); Gothenburg University, Med Tech West, Department of Neuroscience and Rehabilitation, Gothenburg (Sweden); Nordberg, Agneta [Karolinska Institutet, Department NVS, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Stockholm (Sweden); Karolinska University Hospital Huddinge, Department of Geriatric Medicine, Stockholm (Sweden); Karolinska Institutet, Department NVS, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Huddinge (Sweden)

    2014-11-15

    The Alzheimer's disease (AD) pathology is characterized by fibrillar amyloid deposits and neurofibrillary tangles, as well as the activation of astrocytosis, microglia activation, atrophy, dysfunctional synapse, and cognitive impairments. The aim of this study was to test the hypothesis that astrocytosis is correlated with reduced gray matter density in prodromal AD. Twenty patients with AD or mild cognitive impairment (MCI) underwent multi-tracer positron emission tomography (PET) studies with {sup 11}C-Pittsburgh compound B ({sup 11}C-PIB), {sup 18}F-Fluorodeoxyglucose ({sup 18}F-FDG), and {sup 11}C-deuterium-L-deprenyl ({sup 11}C-DED) PET imaging, as well as magnetic resonance imaging (MRI) scanning, cerebrospinal fluid (CSF) biomarker analysis, and neuropsychological assessments. The parahippocampus was selected as a region of interest, and each value was calculated for four different imaging modalities. Correlation analysis was applied between DED slope values and gray matter (GM) densities by MRI. To further explore possible relationships, correlation analyses were performed between the different variables, including the CSF biomarker. A significant negative correlation was obtained between DED slope values and GM density in the parahippocampus in PIB-positive (PIB + ve) MCI patients (p = 0.025) (prodromal AD). Furthermore, in exploratory analyses, a positive correlation was observed between PIB-PET retention and DED binding in AD patients (p = 0.014), and a negative correlation was observed between PIB retention and CSF Aβ42 levels in MCI patients (p = 0.021), while the GM density and CSF total tau levels were negatively correlated in both PIB + ve MCI (p = 0.002) and MCI patients (p = 0.001). No significant correlation was observed with FDG-PET and with any of the other PET, MRI, or CSF biomarkers. High astrocytosis levels in the parahippocampus of PIB + ve MCI (prodromal AD) patients suggest an early preclinical influence on cellular tissue loss. The

  3. Astrocytosis measured by 11C-deprenyl PET correlates with decrease in gray matter density in the parahippocampus of prodromal Alzheimer's patients

    International Nuclear Information System (INIS)

    Choo, IL Han; Carter, Stephen F.; Schoell, Michael L.; Nordberg, Agneta

    2014-01-01

    The Alzheimer's disease (AD) pathology is characterized by fibrillar amyloid deposits and neurofibrillary tangles, as well as the activation of astrocytosis, microglia activation, atrophy, dysfunctional synapse, and cognitive impairments. The aim of this study was to test the hypothesis that astrocytosis is correlated with reduced gray matter density in prodromal AD. Twenty patients with AD or mild cognitive impairment (MCI) underwent multi-tracer positron emission tomography (PET) studies with 11 C-Pittsburgh compound B ( 11 C-PIB), 18 F-Fluorodeoxyglucose ( 18 F-FDG), and 11 C-deuterium-L-deprenyl ( 11 C-DED) PET imaging, as well as magnetic resonance imaging (MRI) scanning, cerebrospinal fluid (CSF) biomarker analysis, and neuropsychological assessments. The parahippocampus was selected as a region of interest, and each value was calculated for four different imaging modalities. Correlation analysis was applied between DED slope values and gray matter (GM) densities by MRI. To further explore possible relationships, correlation analyses were performed between the different variables, including the CSF biomarker. A significant negative correlation was obtained between DED slope values and GM density in the parahippocampus in PIB-positive (PIB + ve) MCI patients (p = 0.025) (prodromal AD). Furthermore, in exploratory analyses, a positive correlation was observed between PIB-PET retention and DED binding in AD patients (p = 0.014), and a negative correlation was observed between PIB retention and CSF Aβ42 levels in MCI patients (p = 0.021), while the GM density and CSF total tau levels were negatively correlated in both PIB + ve MCI (p = 0.002) and MCI patients (p = 0.001). No significant correlation was observed with FDG-PET and with any of the other PET, MRI, or CSF biomarkers. High astrocytosis levels in the parahippocampus of PIB + ve MCI (prodromal AD) patients suggest an early preclinical influence on cellular tissue loss. The lack of correlation between

  4. Metabolic and production profiles of dairy cows in response to decreased nutrient density to increase physiological imbalance at different stages of lactation

    DEFF Research Database (Denmark)

    Bjerre-Harpøth, Vibeke; Friggens, N C; Thorup, Vivi Mørkøre

    2012-01-01

    . Blood was collected daily and analyzed for metabolites: nonesterified fatty acids (NEFA), BHBA, glucose, plasma urea nitrogen, and insulin. The revised quantitative insulin sensitivity check index (RQUICKI) was calculated for each cow. Liver biopsies collected before and during restriction were analyzed...... for triglycerides, glycogen, phospholipids, glucose, and total lipid content. A generalized linear mixed model was used to determine the effect of stage of lactation on responses during restriction. Regression analyses were used to examine the effect of pre-restriction levels on changes during restriction. Similar...... decreases in milk yield among groups indicate that the capacity of individual responses is dependent on milk yield but the coping strategies used are dependent on stage of lactation. Milk yield was a better predictor of feed intake than DIM. Plasma glucose decreased for all cows, and cows in early lactation...

  5. A personagem dostoievskiana e a relação autor/herói em Grande sertão: veredas / The Dostoevskian character and the relationship author/hero in Grande sertão: veredas

    Directory of Open Access Journals (Sweden)

    Sandra Mara Moraes Lima

    2011-11-01

    Full Text Available RESUMO: O trabalho tece considerações sobre o enfoque da personagem pelo autor no romance de Dostoiévski a partir da obra Problemas da poética de Dostoiévski de Bakhtin, estabelecendo uma analogia entre a relação autor/herói na obra de Dostoiévski e a relação autor/herói no romance Grande sertão: veredas, de Guimarães Rosa. Segundo Bakhtin, Dostoiévski inaugura o romance polifônico, dialógico, apresentando um herói cuja voz está equiparada à voz do autor. É nesse mesmo contexto que se analisa, no romance rosiano, o narrador Riobaldo. ABSTRACT: This work makes considerations about the focus of the character by the author on Dostoevsky romance from the work Problems of Dostoevsky’s Poetics of Bakhtin, establishing an analogy between author/hero in Dostoevsky work and the relationship author/hero in the romance Grande sertão: veredas from Guimarães Rosa. According toBakhtin Dostoevsky inaugurates the polyphonic, dialogical, presenting a hero whose voice is equalized to the author voice. In this context we presented the narrator Riobaldo.

  6. Association of pioglitazone treatment with decreased bone mineral density in obese premenopausal patients with polycystic ovary syndrome: a randomized, placebo-controlled trial

    DEFF Research Database (Denmark)

    Glintborg, D.; Andersen, Mikael; Hagen, C.

    2008-01-01

    OBJECTIVE: Our objective was to investigate the effect of pioglitazone on bone mineral density (BMD) and bone turnover markers in polycystic ovary syndrome (PCOS). DESIGN AND SETTING: We conducted a randomized, placebo-controlled study at an outpatient clinic at a university hospital. PATIENTS......: Thirty premenopausal patients with PCOS and 14 age- and weight-matched healthy females participated. INTERVENTIONS: Pioglitazone (30 mg/d) or placebo was given for 16 wk. MAIN OUTCOME MEASURES: Measurements of BMD [hip (neck and total) and lumbar spine (L2-L4)], bone metabolic parameters [alkaline...... phosphatase (ALP), 25-hydroxyvitamin D, C-telopeptide of type I collagen (ICTP), osteocalcin, and PTH], endocrine profiles (testosterone, estradiol, and insulin), and body composition (waist to hip ratio, body mass index, and whole-body dual-energy x-ray absorptiometry scans) were performed. RESULTS: Patients...

  7. A qualidade de vida na população idosa do concelho da Sertã : estudo exploratório

    OpenAIRE

    Santos, Susana Isabel Antunes Chamusca da Cunha e

    2011-01-01

    O presente estudo debruçou-se sobre a Qualidade de Vida na População Idosa do Concelho da Sertã, em diferentes contextos habitacionais: em regime de instituição (lar ou centro de dia) e em regime de residência própria sem estarem associados a qualquer instituição. Trata-se de um estudo exploratório, com dois objectivos principais: 1) conhecer e comparar a qualidade de vida dos idosos do concelho da Sertã em diferentes regimes habitacionais; 2) construir um questionário de avaliação da qual...

  8. Mg IX emission lines in an active region spectrum obtained with the Solar EUV Rocket Telescope and Spectrograph (SERTS)

    Science.gov (United States)

    Keenan, F. P.; Thomas, R. J.; Neupert, W. M.; Conlon, E. S.

    1994-01-01

    Theoretical electron-temperature-sensitive Mg IX emission line ratios are presented for R(sub 1) = I(443.96 A)/I(368.06 A), R(sub 2) = I(439.17 A)/I(368.06 A), R(sub 3) = I(443.37 A)/I(368.06 A), R(sub 4) = I(441.22 A)/I(368.06 A), and R(sub 5) = I(448.28 A)/I(368.06 A). A comparison of these with observational data for a solar active region, obtained during a rocket flight by the Solar EUV Rocket Telescope and Spectrograph (SERTS), reveals excellent agreement between theory and observation for R(sub 1) through R(sub 4), with discrepancies that average only 9%. This provides experimental support for the accuracy of the atomic data adopted in the line ratio calculations, and also resolves discrepancies found previously when the theoretical results were compared with solar data from the S082A instrument on board Skylab. However in the case of R(sub 5), the theoretical and observed ratios differ by almost a factor of 2. This may be due to the measured intensity of the 448.28 A line being seriously affected by instrumental effects, as it lies very close to the long wavelength edge of the SERTS spectral coverage (235.46-448.76 A).

  9. Population differentiation and behavioural association of the two 'personality' genes DRD4 and SERT in dunnocks (Prunella modularis).

    Science.gov (United States)

    Holtmann, B; Grosser, S; Lagisz, M; Johnson, S L; Santos, E S A; Lara, C E; Robertson, B C; Nakagawa, S

    2016-02-01

    Quantifying the variation in behaviour-related genes within and between populations provides insight into how evolutionary processes shape consistent behavioural traits (i.e. personality). Deliberate introductions of non-native species offer opportunities to investigate how such genes differ between native and introduced populations and how polymorphisms in the genes are related to variation in behaviour. Here, we compared the genetic variation of the two 'personality' genes, DRD4 and SERT, between a native (United Kingdom, UK) and an introduced (New Zealand, NZ) population of dunnocks, Prunella modularis. The NZ population showed a significantly lower number of single nucleotide polymorphisms (SNPs) compared to the UK population. Standardized F'st estimates of the personality genes and neutral microsatellites indicate that selection (anthropogenic and natural) probably occurred during and post the introduction event. Notably, the largest genetic differentiation was found in the intronic regions of the genes. In the NZ population, we also examined the association between polymorphisms in DRD4 and SERT and two highly repeatable behavioural traits: flight-initiation distance and mating status (promiscuous females and cobreeding males). We found 38 significant associations (for different allele effect models) between the two behavioural traits and the studied genes. Further, 22 of the tested associations showed antagonistic allele effects for males and females. Our findings illustrate how introduction events and accompanying ecological changes could influence the genetic diversity of behaviour-related genes. © 2015 John Wiley & Sons Ltd.

  10. Consumption of a liquid high-fat meal increases triglycerides but decreases high-density lipoprotein cholesterol in abdominally obese subjects with high postprandial insulin resistance.

    Science.gov (United States)

    Wang, Feng; Lu, Huixia; Liu, Fukang; Cai, Huizhen; Xia, Hui; Guo, Fei; Xie, Yulan; Huang, Guiling; Miao, Miao; Shu, Guofang; Sun, Guiju

    2017-07-01

    Abdominal obesity is associated with an increased risk of insulin resistance, which may be a potential contributor to dyslipidemia. However, the relationship between postprandial insulin resistance and lipid metabolism in abdominally obese subjects remains unknown. We hypothesized that postprandial dyslipidemia would be exaggerated in abdominally obese subjects with high postprandial insulin resistance. To test this hypothesis, serum glucose, insulin, triglycerides, total cholesterol, high-density lipoprotein cholesterol, and apolipoprotein B were measured at baseline and postprandial state at 0.5, 1, 2, 4, 6, and 8 hours after a liquid high-fat meal in non-abdominally obese controls (n=44) and abdominally obese subjects with low (AO-LPIR, n=40), middle (n=40), and high postprandial insulin resistance (AO-HPIR, n=40) based on the tertiles ratio of the insulin to glucose areas under the curve (AUC). Their serum adipokines were tested at baseline only. Fasting serum leptin was higher (Pinsulin resistance and controls. The present study indicated that the higher degree of postprandial insulin resistance, the more adverse lipid profiles in abdominally obese subjects, which provides insight into opportunity for screening in health. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Metabolic and production profiles of dairy cows in response to decreased nutrient density to increase physiological imbalance at different stages of lactation.

    Science.gov (United States)

    Bjerre-Harpøth, V; Friggens, N C; Thorup, V M; Larsen, T; Damgaard, B M; Ingvartsen, K L; Moyes, K M

    2012-05-01

    Physiological imbalance (PI) is a situation in which physiological parameters deviate from the normal, and cows consequently have an increased risk of developing production diseases and reduced production or reproduction. Our objectives were to (1) determine the effect of stage of lactation and milk yield on metabolic and production responses of cows during a nutrient restriction period to experimentally increase PI; (2) identify major metabolites that relate to degree of PI; and (3) identify potential biomarkers in milk for on-farm detection of PI throughout lactation. Forty-seven Holstein cows in early [n=14; 49±22 d in milk (DIM); parity=1.6±0.5], mid (n=15; 159±39 DIM; parity=1.5±0.5), and late (n=18; 273±3 DIM; parity=1.3±0.5) lactation were used. Prior to restriction, all cows were fed the same total mixed ration ad libitum. All cows were then nutrient restricted for 4 d by supplementing the ration with 60% wheat straw to induce PI. After restriction, cows returned to full feed. Daily milk yield was recorded and composite milk samples were analyzed for fat, protein, lactose, citrate, somatic cells, uric acid, alkaline phosphatase, β-hydroxybutyrate (BHBA), and milk urea nitrogen. Blood was collected daily and analyzed for metabolites: nonesterified fatty acids (NEFA), BHBA, glucose, plasma urea nitrogen, and insulin. The revised quantitative insulin sensitivity check index (RQUICKI) was calculated for each cow. Liver biopsies collected before and during restriction were analyzed for triglycerides, glycogen, phospholipids, glucose, and total lipid content. A generalized linear mixed model was used to determine the effect of stage of lactation on responses during restriction. Regression analyses were used to examine the effect of pre-restriction levels on changes during restriction. Similar decreases in milk yield among groups indicate that the capacity of individual responses is dependent on milk yield but the coping strategies used are dependent on

  12. Lipoprotein Lipase and PPAR Alpha Gene Polymorphisms, Increased Very-Low-Density Lipoprotein Levels, and Decreased High-Density Lipoprotein Levels as Risk Markers for the Development of Visceral Leishmaniasis by Leishmania infantum

    Directory of Open Access Journals (Sweden)

    Márcia Dias Teixeira Carvalho

    2014-01-01

    Full Text Available In visceral leishmaniasis (VL endemic areas, a minority of infected individuals progress to disease since most of them develop protective immunity. Therefore, we investigated the risk markers of VL within nonimmune sector. Analyzing infected symptomatic and, asymptomatic, and noninfected individuals, VL patients presented with reduced high-density lipoprotein cholesterol (HDL-C, elevated triacylglycerol (TAG, and elevated very-low-density lipoprotein cholesterol (VLDL-C levels. A polymorphism analysis of the lipoprotein lipase (LPL gene using HindIII restriction digestion (N = 156 samples (H+ = the presence and H− = the absence of mutation revealed an increased adjusted odds ratio (OR of VL versus noninfected individuals when the H+/H+ was compared with the H−/H− genotype (OR = 21.3; 95% CI = 2.32–3335.3; P = 0.003. The H+/H+ genotype and the H+ allele were associated with elevated VLDL-C and TAG levels (P < 0.05 and reduced HDL-C levels (P < 0.05. An analysis of the L162V polymorphism in the peroxisome proliferator-activated receptor alpha (PPARα gene (n = 248 revealed an increased adjusted OR when the Leu/Val was compared with the Leu/Leu genotype (OR = 8.77; 95% CI = 1.41–78.70; P = 0.014. High TAG (P = 0.021 and VLDL-C (P = 0.023 levels were associated with susceptibility to VL, whereas low HDL (P = 0.006 levels with resistance to infection. The mutated LPL and the PPARα Leu/Val genotypes may be considered risk markers for the development of VL.

  13. Armando Magalhães Corrêa: gente e natureza de um sertão quase metropolitano Armando Magalhães Corrêa: people and nature in an almost metropolitan sertão

    Directory of Open Access Journals (Sweden)

    José Luiz de Andrade Franco

    2005-12-01

    Full Text Available O texto examina o pensamento social e ambiental de Armando Magalhães Corrêa (1889-1944, conforme expresso no livro O sertão carioca (1936. Mostra-se que ele fez parte de uma geração de conservacionistas pioneiros do Brasil, a qual, ao contrário do que geralmente se pensa, soube integrar as dimensões social e natural, aproximando a necessidade de defender a natureza do imperativo de melhorar as condições de vida dos habitantes do interior brasileiro. Ao focalizar as populações do entorno rural da cidade do Rio de Janeiro por volta de 1930, o autor capta num microcosmo as distâncias sociais e culturais entre urbanos e sertanejos brasileiros. Descreve com acuidade o meio natural de uma área em grande parte urbanizada que vai da baixada de Jacarepaguá à Pedra de Guaratiba. Trata das atividades produtivas dos seus habitantes e faz sugestões políticas conservacionistas que vieram a influenciar as políticas governamentais.The article examines the social and environmental thought of Armando Magalhães Corrêa (1889-1944 as expressed in his book O sertão carioca (1936. He was part of a generation of pioneer conservationists in Brazil who-contrary to what is generally believed-were able to bring the social and natural dimensions together, blending the need to defend nature with the imperative of improving the living conditions for people in Brazil's interior. Focusing on people residing in the rural outskirts of Rio de Janeiro city around 1930, Corrêa captures a microcosm that illustrates the social and cultural distances separating Brazilian urbanites and sertão dwellers. He provides clear descriptions of the natural world within a largely urbanized area that stretches from the Jacarepaguá lowlands to Pedra de Guaratiba. He explores the productive activities of the region's inhabitants and makes conservationist suggestions that were to influence governmental policy.

  14. A guerra como painel e espetáculo: a história encenada em Os sertões War as a picture and a spectacle: history staged in Os sertões

    Directory of Open Access Journals (Sweden)

    Berthold Zilly

    1998-07-01

    Full Text Available O artigo considera os motivos do sucesso de Os sertões como relato consagrado sobre a guerra de Canudos e os destinos da nação brasileira. Sua originalidade não consiste nos fatos referidos nem nas reflexões científicas e antropológicas sobre eles, mas no modo plástico, sugestivo e emocionante pelo qual os eventos são evocados e presentificados. A história é descrita mediante o uso da retórica e imagens de caráter bíblico e mitológico. O livro configura-se como encenação pictórica e teatral. A solidariedade do espectador-narrador vacila entre a inevitável civilização e a utópica comunidade de Canudos, entre a condenação e a apoteose do sertanejo insubmisso, entre a aceitação da sua morte e sua imortalização no plano simbólico, resultando numa visão trágica da história.The paper inquires upon the reasons for the continual success of Os sertões as a hallowed narrative about the Canudos War and the destiny of Brazil as a nation. The work owes its originality not to the facts it narrates nor to the scientific and anthropological views expressed about such facts, but rather to the pictorial, suggestive, moving way in which they are remembered and made present. The story is described and narrated with the use of imagery and rhetoric. Os sertões constitutes itself as a vividly pictorial and dramatic tour de force, both from the perspective of its composition and of its syntactical structure. Empathy felt by the spectator-narrator sways between unavoidable civilization and Utopian Canudos community, between disapproval, and glorification of the rebellious backlanders, between the acceptance of their elimination and the wish for their becoming immortals at the symbolic level-the work as a whole leading to the formation of a tragic view of history.

  15. Correction to: Dapagliflozin decreases small dense low-density lipoprotein-cholesterol and increases high-density lipoprotein 2-cholesterol in patients with type 2 diabetes: comparison with sitagliptin.

    Science.gov (United States)

    Hayashi, Toshiyuki; Fukui, Tomoyasu; Nakanishi, Noriko; Yamamoto, Saki; Tomoyasu, Masako; Osamura, Anna; Ohara, Makoto; Yamamoto, Takeshi; Ito, Yasuki; Hirano, Tsutomu

    2017-11-13

    Following publication of the original article [1], the authors identified a number of errors. In Result (P.3), Table 1 (P.4), Table 5 (P.9) and Supplementary Table 1, the correct unit for adiponectin was μg/mL. In Table 1 (P.4), the correct value for the post treatment body weight in dapagliflozin was 76.2±14.8. In Table 6 (P.10), the correct value for the pre treatment sd LDL/LDL-C in decreased LDL-C group was 0.38±0.10.

  16. Visões do deserto: selva e sertão em Euclides da Cunha Visions of the desert: jungle and backlands in Euclides da Cunha

    Directory of Open Access Journals (Sweden)

    Roberto Ventura

    1998-07-01

    Full Text Available Euclides da Cunha abordou duas regiões tidas como pouco propícias ao homem: o sertão baiano e a selva amazônica. Escreveu, em 1897, reportagens sobre a guerra de Canudos para O Estado de S. Paulo e publicou, em 1902, Os sertões. Fez, em 1905, expedição de reconhecimento do Alto Purus e redigiu os ensaios sobre a Amazônia, reunidos em Contrastes e confrontos (1907 e em À margem da história (1909. Recorreu, em seus escritos sobre Canudos e a Amazônia, à imagem do deserto para caracterizar a selva e sertão como territórios ainda não explorados pela ciência.Euclides da Cunha addressed himself to two regions considered inhospitable to man: the backlands of Bahia and the Amazon jungle. In 1897, he wrote articles about the battle of Canudos for the O Estado de S. Paulo, publishing Os sertões in 1902. After exploring the Purus River in 1905, he composed the essays on the Amazon collected in Contrastes e confrontos (1907 and À margem da história (1909. In his writings on these regions, Cunha uses images of the desert to characterize both jungle and backlands as territories not yet explored by science.

  17. Vida de agricultoras e histórias de documentos no Sertão Central de Pernambuco Lives of peasant and worker women and stories of documents in the South Central Sertão of Pernambuco

    Directory of Open Access Journals (Sweden)

    Rosineide de L. Meira Cordeiro

    2007-08-01

    Full Text Available O artigo enfoca como as mulheres agricultoras, ao terem acesso a direitos sociais, especialmente à Previdência Social, lidam com a normatização e a regulamentação dos processos de nascimento, envelhecimento e morte. O objetivo é analisar as dificuldades e as estratégias que as mulheres utilizam para cumprirem as exigências legais de comprovação do trabalho na agricultura familiar através de documentos civis e profissionais. A pesquisa foi realizada nos municípios de Santa Cruz da Baixa Verde e Triunfo, situados no Sertão de Pernambuco, Nordeste do Brasil. A ausência de documentos é reveladora dos parâmetros de modernidade instaurados no país e deve ser entendida à luz das intersecções de gênero, classe, raça, etnia e critérios geopolíticos.The article focuses on how peasant and worker women deal with norms and rules about birth, ageing and death, in the process of getting access to social rights, especially to Social Security. The aim is to analyze difficulties and strategies used by women in order to comply with the legal demands of proof of work experience in family farming by way of civil and professional documents. Research was undertaken in the municipalities of Santa Cruz da Baixa Verde and Triunfo, in the Pernambuco Sertão in Northeast Brazil. The absence of documents reveals how parameters of modernity are installed in the nation, understanding them as necessarily related to gender, class, race, ethnicity and geopolitical criteria.

  18. Appetite - decreased

    Science.gov (United States)

    Loss of appetite; Decreased appetite; Anorexia ... Any illness can reduce appetite. If the illness is treatable, the appetite should return when the condition is cured. Loss of appetite can cause weight ...

  19. The SERTS-97 Rocket Experiment on Study Activity on the Sun: Flight 36.167-GS on 1997 November 18

    Science.gov (United States)

    Swartz, Marvin; Condor, Charles E.; Davila, Joseph M.; Haas, J. Patrick; Jordan, Stuart D.; Linard, David L.; Miko, Joseph J.; Nash, I. Carol; Novello, Joseph; Payne, Leslie J.; hide

    1999-01-01

    This paper describes mainly the 1997 version of the Solar EUV Rocket Telescope and Spectrograph (SERTS-97), a scientific experiment that operated on NASA's suborbital rocket flight 36.167-GS. Its function was to study activity on the Sun and to provide a cross calibration for the CDS instrument on the SOHO satellite. The experiment was designed, built, and tested by the Solar Physics Branch of the Laboratory for Astronomy and Solar Physics at the Goddard Space Flight Center (GSFC). Other essential sections of the rocket were built under the management of the Sounding Rockets Program Office. These sections include the electronics, timers, IGN despin, the SPARCS pointing controls, the S-19 flight course correction section, the rocket motors, the telemetry, ORSA, and OGIVE.

  20. Imaging of the brain serotonin transporters (SERT) with {sup 18}F-labelled fluoromethyl-McN5652 and PET in humans

    Energy Technology Data Exchange (ETDEWEB)

    Hesse, Swen [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Leipzig University Medical Center, AdiposityDiseases, Leipzig (Germany); Brust, Peter [Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmacy, Research Site Leipzig, Leipzig (Germany); Maeding, Peter; Zessin, Joerg; Fuechtner, Frank [Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmacy, Dresden (Germany); Becker, Georg-Alexander; Patt, Marianne; Seese, Anita; Sorger, Dietlind; Meyer, Philipp M.; Habermann, Bernd; Luthardt, Julia; Bresch, Anke; Sabri, Osama [University of Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Lobsien, Donald [University of Leipzig, Department of Neuroradiology, Leipzig (Germany); Laudi, Sven [University of Leipzig, Department of Anaesthesiology and Intensive Care, Leipzig (Germany); Steinbach, Joerg [Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmacy, Dresden (Germany); Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmacy, Research Site Leipzig, Leipzig (Germany)

    2012-06-15

    [{sup 11}C]DASB is currently the most frequently used highly selective radiotracer for visualization and quantification of central SERT. Its use, however, is hampered by the short half-life of {sup 11}C, the moderate cortical test-retest reliability, and the lack of quantifying endogenous serotonin. Labelling with {sup 18}F allows in principle longer acquisition times for kinetic analysis in brain tissue and may provide higher sensitivity. The aim of our study was to firstly use the new highly SERT-selective {sup 18}F-labelled fluoromethyl analogue of (+)-McN5652 ((+)-[{sup 18}F]FMe-McN5652) in humans and to evaluate its potential for SERT quantification. The PET data from five healthy volunteers (three men, two women, age 39 {+-} 10 years) coregistered with individual MRI scans were semiquantitatively assessed by volume-of-interest analysis using the software package PMOD. Rate constants and total distribution volumes (V{sub T}) were calculated using a two-tissue compartment model and arterial input function measurements were corrected for metabolite/plasma data. Standardized uptake region-to-cerebellum ratios as a measure of specific radiotracer accumulation were compared with those of a [{sup 11}C]DASB PET dataset from 21 healthy subjects (10 men, 11 women, age 38 {+-} 8 years). The two-tissue compartment model provided adequate fits to the data. Estimates of total distribution volume (V{sub T}) demonstrated good identifiability based on the coefficients of variation (COV) for the volumes of interest in SERT-rich and cortical areas (COV V{sub T} <10%). Compared with [{sup 11}C]DASB PET, there was a tendency to lower mean uptake values in (+)-[{sup 18}F]FMe-McN5652 PET; however, the standard deviation was also somewhat lower. Altogether, cerebral (+)-[{sup 18}F]FMe-McN5652 uptake corresponded well with the known SERT distribution in humans. The results showed that (+)-[{sup 18}F]FMe-McN5652 is also suitable for in vivo quantification of SERT with PET. Because of

  1. Streptozocin-induced type-1 diabetes mellitus results in decreased density of CGRP sensory and TH sympathetic nerve fibers that are positively correlated with bone loss at the mouse femoral neck.

    Science.gov (United States)

    Enríquez-Pérez, Iris A; Galindo-Ordoñez, Karla E; Pantoja-Ortíz, Christian E; Martínez-Martínez, Arisaí; Acosta-González, Rosa I; Muñoz-Islas, Enriqueta; Jiménez-Andrade, Juan M

    2017-08-10

    Type-1 diabetes mellitus (T1DM) results in loss of innervation in some tissues including epidermis and retina; however, the effect on bone innervation is unknown. Likewise, T1DM results in pathological bone loss and increased risk of fracture. Thus, we quantified the density of calcitonin gene-related peptide (CGRP + ) sensory and tyrosine hydroxylase (TH + ) sympathetic nerve fibers and determined the association between the innervation density and microarchitecture of trabecular bone at the mouse femoral neck. Ten weeks-old female mice received 5 daily administrations of streptozocin (i.p. 50mg/kg) or citrate (control group). Twenty weeks later, femurs were analyzed by microCT and processed for immunohistochemistry. Confocal microscopy analysis revealed that mice with T1DM had a significant loss of both CGRP + and TH + nerve fibers in the bone marrow at the femoral neck. Likewise, microCT analysis revealed a significant decrease in the trabecular bone mineral density (tBMD), bone volume/total volume ratio (BV/TB), trabecular thickness (Tb.Th), trabecular number (Tb.N) and trabecular separation (Tb.Sp) in mice with T1DM as compared to control mice. Analysis of correlation revealed a positive and significant association between density of CGRP + or TH + nerve fibers with tBMD, BV/TV, Tb.Th and Tb.Sp, but not with trabecular number (there was a positive association only for CGRP + ) and degree of anisotropy (DA). This study suggests an interaction between sensory and sympathetic nervous system and T1DM-induced bone loss. Identification of the factors involved in the loss of CGRP + sensory and TH + sympathetic fibers and how they regulate bone loss may result in new avenues to treat T1DM-related osteoporosis. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Intoxicações por plantas em ruminantes e equídeos no Sertão Paraibano Plant poisonings in ruminants and equidae in the Sertão of Paraiba, Brazil

    Directory of Open Access Journals (Sweden)

    Tales S. Assis

    2009-11-01

    Full Text Available Foi realizado um levantamento das intoxicações por plantas em 20 municípios do Sertão Paraibano, onde foram entrevistados 50 produtores e 11 médicos veterinários. De acordo com o levantamento realizado, Ipomoea asarifolia e Mascagnia rigida são as intoxicações mais importantes. Indigofera suffruticosa, as plantas cianogênicas (Sorghum vulgare, Piptadenia macrocarpa e Manihot spp., Mimosa tenuiflora, Aspidosperma pyrifolium e Crotalaria retusa são plantas importantes como causa de intoxicações na região. Os entrevistados relataram casos esporádicos de intoxicação por Ricinus communis, Enterolobium contortisiliquum, Prosopis juliflorae Brachiaria decumbens. Ziziphus joazeiro, Passiflora sp., Caesalpina ferrea e Crescentia cujete foram mencionadas como causa de abortos em ruminantes. Frutos de Crescentia cujete foram administrados a duas cabras prenhes causando mortalidade perinatal e abortos. As cascas de feijão (Phaseolus vulgaris e Vigna unguiculata e as folhas de Licania rigida (oiticica são associadas à sobrecarga ruminal em bovinos. As frutas de Mangifera indica (mangae Anacardium occidentale (cajú são responsabilizadas por causarem intoxicação etílica. Dalechampia sp. e Croton sp. foram citadas pelos entrevistados como possíveis plantas tóxicas, que ainda não tiveram sua toxicidade comprovada.A survey of plant poisoning in ruminants and equidae was conducted in 20 municipalities of the semiarid region of the Sertão Paraibano. Fifty farmers and 11 veterinary practitioners were interviewed. Ipomoea asarifolia and Mascagnia rigida are the most important poisonous plants in the region. Indigofera suffruticosa, the cianogenic plants (Sorghum vulgare, Piptadenia macrocarpa, and Manihot spp., Mimosa tenuiflora, Aspidosperma pyrifolium and Crotalaria retusa cause also important intoxications in the area. Sporadic outbreaks of poisonings by Ricinus communis, Enterolobium contortisiliquum, Prosopis juliflora and Brachiaria

  3. serts alimentaires à Winnipeg (Canada : une nouvelle méthodologie de mesure d'un concept complexe et controversé

    Directory of Open Access Journals (Sweden)

    Joyce Slater

    2017-01-01

    Full Text Available Introduction : Les « déserts alimentaires » ont vu le jour dans les 20 dernières années et forment des secteurs préoccupants pour les collectivités, les autorités en santé publique et les chercheurs en raison de leur effet négatif possible sur la qualité de l’alimentation et en raison de leurs conséquences sur la santé. Ce sont des espaces résidentiels, habituellement en milieu urbain, où les résidents à faible revenu n’ont que peu ou pas accès à des établissements de vente au détail d'aliments qui offrent suffisamment de variété à un prix abordable. La recherche sur les déserts alimentaires présente des défis méthodologiques, notamment la façon de repérer et de classer les magasins d’alimentation au détail, la définition de la population à faible revenu ainsi que les paramètres concernant le transport et la proximité. De plus, les méthodes complexes qui sont souvent employées dans la recherche sur les déserts alimentaires peuvent être difficiles à reproduire et à communiquer aux principaux intervenants. Pour surmonter ces difficultés, nous avons voulu montrer qu’on pouvait concevoir une méthode simple et reproductible pour repérer les déserts alimentaires, à l’aide de données facilement accessibles en contexte canadien. Méthodologie : Cette étude a été menée à Winnipeg (Canada en 2014. Les établissements de vente au détail des aliments ont été trouvés à l’aide des Pages Jaunes et vérifiés par des diététistes en santé publique. Nous avons créé deux scénarios sur les déserts alimentaires en fonction de l’emplacement de la population à quintile de revenu le plus faible : a celle qui habitait à 500 m ou plus d’une épicerie appartenant à une chaîne nationale et b celle qui habitait à 500 m ou plus d’une épicerie appartenant à une chaîne nationale ou d’une épicerie à service complet. Résultats : En fonction du scénario utilisé, 64 574 ou 104 335 r

  4. Measuring SSRI occupancy of SERT using the novel tracer [{sup 123}I]ADAM: a SPECT validation study

    Energy Technology Data Exchange (ETDEWEB)

    Erlandsson, Kjell; Lui, Dominic; Townsend, Caroline E.; Ell, Peter J. [Middlesex Hospital, Institute of Nuclear Medicine, University College London, London (United Kingdom); Sivananthan, Tharani; Mu, Song; Lucas, Richard [Lilly Research Centre, Eli Lilly and Company, Windlesham, Surrey (United Kingdom); Spezzi, Andrea; Warrington, Steven [Central Middlesex Hospital, Hammersmith Medicines Research, London (United Kingdom)

    2005-11-01

    Serotonergic brain regions play a crucial role in the modulation of emotion, and serotonergic dysfunction may contribute to several neurological disorders. [{sup 123}I]ADAM is a novel SPECT tracer which binds with high affinity to serotonin transporters (SERT). The objective of this study was to compare different methods for the quantification of tracer binding and to develop a simplified single-scan protocol for this tracer, as well as to investigate its potential for characterisation of the transporter occupancy versus plasma concentration curve of a selective serotonin re-uptake inhibitor (SSRI). Dynamic SPECT scans were performed on 16 healthy volunteers after administration of {proportional_to}150 MBq [{sup 123}I]ADAM. Data were acquired from the time of injection until {proportional_to}5.5 h after injection in 30- or 45-min sessions. Each subject was scanned twice: with and without pre-treatment with the SSRI citalopram in various dosage regimens. The plasma concentration of citalopram (C{sub p}) was determined from venous samples. Images were reconstructed by filtered back-projection with scatter and attenuation correction. Tracer binding was quantified for midbrain, striatum and thalamus using cerebellum as a reference region. Quantification was done by kinetic modelling, graphical analysis and multi-linear regression, as well as by the ratio method, with binding potential (BP{sub 2}) as the outcome measure. The SERT occupancy by citalopram was determined relative to the baseline scan for each subject, and the occupancy versus C{sub p} curve was fitted with the E{sub max} model. The highest binding of [{sup 123}I]ADAM was in midbrain (mean baseline BP{sub 2}{+-}SD=1.31{+-}0.29), with lower binding in thalamus (0.79{+-}0.16) and striatum (0.66{+-}0.13). There was good agreement between BP{sub 2} values obtained by different quantification methods. Using the ratio method, the best agreement with kinetic modelling was obtained with data from the time interval

  5. Measuring SSRI occupancy of SERT using the novel tracer [123I]ADAM: a SPECT validation study

    International Nuclear Information System (INIS)

    Erlandsson, Kjell; Lui, Dominic; Townsend, Caroline E.; Ell, Peter J.; Sivananthan, Tharani; Mu, Song; Lucas, Richard; Spezzi, Andrea; Warrington, Steven

    2005-01-01

    Serotonergic brain regions play a crucial role in the modulation of emotion, and serotonergic dysfunction may contribute to several neurological disorders. [ 123 I]ADAM is a novel SPECT tracer which binds with high affinity to serotonin transporters (SERT). The objective of this study was to compare different methods for the quantification of tracer binding and to develop a simplified single-scan protocol for this tracer, as well as to investigate its potential for characterisation of the transporter occupancy versus plasma concentration curve of a selective serotonin re-uptake inhibitor (SSRI). Dynamic SPECT scans were performed on 16 healthy volunteers after administration of ∝150 MBq [ 123 I]ADAM. Data were acquired from the time of injection until ∝5.5 h after injection in 30- or 45-min sessions. Each subject was scanned twice: with and without pre-treatment with the SSRI citalopram in various dosage regimens. The plasma concentration of citalopram (C p ) was determined from venous samples. Images were reconstructed by filtered back-projection with scatter and attenuation correction. Tracer binding was quantified for midbrain, striatum and thalamus using cerebellum as a reference region. Quantification was done by kinetic modelling, graphical analysis and multi-linear regression, as well as by the ratio method, with binding potential (BP 2 ) as the outcome measure. The SERT occupancy by citalopram was determined relative to the baseline scan for each subject, and the occupancy versus C p curve was fitted with the E max model. The highest binding of [ 123 I]ADAM was in midbrain (mean baseline BP 2 ±SD=1.31±0.29), with lower binding in thalamus (0.79±0.16) and striatum (0.66±0.13). There was good agreement between BP 2 values obtained by different quantification methods. Using the ratio method, the best agreement with kinetic modelling was obtained with data from the time interval [200,260] min after injection. The fitting of the midbrain occupancy curve

  6. Characterization of 4-[18F]-ADAM as an imaging agent for SERT in non-human primate brain using PET: a dynamic study

    International Nuclear Information System (INIS)

    Chen, Yu-An; Huang, Wen-Sheng; Lin, Yaoh-Shiang; Cheng, Cheng-Yi; Liu, Ren-Shyan; Wang, Shyh-Jen; Li, I-Hsun; Huang, San-Yuan; Shiue, Chyng-Yann; Chen, Cheng-Yu; Ma, Kuo-Hsing

    2012-01-01

    Introduction: Serotonin transporter (SERT) has been associated with many psychiatric diseases. This study investigated the biodistribution of a serotonin transporter imaging agent, N,N-dimethyl-2-(2-amino-4- 18 F-fluorophenylthio)benzylamine (4-[ 18 F]-ADAM), in nonhuman primate brain using positron emission tomography (PET). Methods: Six and four Macaca cyclopis monkeys were used to determine the transit time (i.e., time necessary to reach biodistribution equilibrium) and the reproducibility of 4-[ 18 F]-ADAM biodistribution in the brain, respectively. The sensitivity and specificity of 4-[ 18 F]-ADAM binding to SERT were evaluated in one monkey challenged with different doses of fluoxetine and one monkey treated with 3,4-methylendioxymethamphetamine (MDMA). Dynamic PET imaging was performed for 3 h after 4-[ 18 F]-ADAM intravenous bolus injection. The specific uptake ratios (SURs) in the midbrain (MB), thalamus (TH), striatum (ST) and frontal cortex (FC) were calculated. Results: The distribution of 4-[ 18 F]-ADAM reached equilibrium 120–150 min after injection. The mean SURs were 2.49±0.13 in MB, 1.59±0.17 in TH, 1.35±0.06 in ST and 0.34±0.03 in FC, and the minimum variability was shown 120–150 min after 4-[ 18 F]-ADAM injection. Using SURs and intraclass coefficient of correlation, the test/retest variability was under 8% and above 0.8, respectively, in SERT-rich areas. Challenge with fluoxetin (0.75–2 mg) dose-dependently inhibited the SURs in various brain regions. 4-[ 18 F]-ADAM binding was markedly reduced in the brain of an MDMA-treated monkey compared to that in brains of normal controls. Conclusion: 4-[ 18 F]-ADAM appears to be a highly selective radioligand for imaging SERT in monkey brain.

  7. Hypervariable region 1 deletion and required adaptive envelope mutations confer decreased dependency on scavenger receptor class B type I and low-density lipoprotein receptor for hepatitis C virus

    DEFF Research Database (Denmark)

    Prentoe, Jannick; Serre, Stéphanie B N; Ramirez, Santseharay

    2014-01-01

    -deleted viruses. Apolipoprotein E (ApoE)-specific HCV neutralization was similar for H77, J6, and S52 viruses with and without HVR1. In conclusion, HVR1 and HVR1-related adaptive envelope mutations appeared to be involved in LDLr and SR-BI dependency, respectively. Also, LDLr served Apo....../S733F), S52(ΔHVR1/A369V), and S52(A369V), but not for J6(ΔHVR1). Low-density lipoprotein receptor (LDLr) dependency was decreased for HVR1-deleted viruses, but not for H77(N476D/S733F) and S52(A369V). Soluble LDLr neutralization revealed strong inhibition of parental HCV but limited effect against HVR1...

  8. Drought in the sertão as a natural or social phenomenon: establishing the Inspetoria Federal de Obras Contra as Secas, 1909-1923

    Directory of Open Access Journals (Sweden)

    Eve Elizabeth Buckley

    2010-01-01

    Full Text Available This paper examines interpretations of the drought problem in Brazil's northeast sertão during the First Republic. It compares analysis of drought as primarily a natural or climatic phenomenon – embraced by civil engineers working for the Inspetoria [Federal] de Obras Contra as Secas (IFOCS – with analyses emphasizing social and political conditions that made drought a crisis for the sertanejo poor. The latter are evident in the report of doctors Belisário Penna and Artur Neiva describing their expedition through the sertão sponsored by IFOCS in 1912. This comparison allows for consideration of the intersection between natural (geographic, climatic and social (political, cultural factors that produced the region's periodic crisis. The analysis is informed by the work of social scientists who highlight the multi-dimensional causes underlying natural disasters in politically marginal communities. Technocrats' faith in the context-independent utility of their expertise lay at the heart of IFOCS's ultimate failure to rescue sertanejos from famine, migration and poverty. Because the drought agency's technical personnel never had the political will or muscle to confront the social organization underlying the sertão's recurrent calamity, their ability to alleviate the human suffering that droughts precipitated was severely limited.

  9. Fitossociologia de plantas espontâneas sob cultivo agroecológico na bananeira no Sertão Paraibano

    Directory of Open Access Journals (Sweden)

    Marilia Hortência Batista Silva Rodrigues

    2017-02-01

    Full Text Available Plantas são organismos sésseis e, portanto, refletem as condições locais. Elas apresentam geralmente maiores níveis de plasticidade fenotípica comparado aos animais, o que significa que efeitos de diversos estressores podem ser mais aparentes e, potencialmente, mais fáceis de serem medidos e quantificados. Este trabalho objetivou realizar um levantamento fitossociológico das espécies de plantas espontâneas presentes no cultivo de diferentes genótipos de banana sob manejo agroecológico no Alto Sertão Paraibano. Foi realizado em uma área experimental de 1.512m2. O espaçamento entre plantas foi de 3x3 m. Para a identificação e quantificação de plantas espontâneas, foi utilizado o método do quadrado inventário. Foram calculados: frequência, frequência relativa, densidade, densidade relativa, abundância, abundância relativa e o índice de importância relativa. Foram identificadas um total de 93 indivíduos correspondentes a 21 espécies, distribuídas em 11 famílias. A área em estudo apresentou uma grande diversidade de plantas espontâneas no cultivo da banana, sendo a mais frequente (18,18% e com maior densidade relativa (38,70% a espécie Cyperus rotundus, seguido da Alternanthera tenella com frequência relativa de 13,63% e densidade relativa de 15,05%.Phytosociology of spontaneous plants under agroecological cultivation in the banana tree in backlands of Paraiba Abstract: Plants are sessile organisms and therefore reflect local conditions. They generally have higher levels of phenotypic plasticity compared to animals, which means that the effects of various stressors may be more apparent and potentially easier to measure and quantify. This work aimed to perform a phytosociological survey of the species of spontaneous plants present in the cultivation of different banana genotypes under agroecological management in Hinterland Paraibano. It was carried out in an experimental area of 1,512m2. The spacing between plants

  10. Leptin Intake at Physiological Doses Throughout Lactation in Male Wistar Rats Normalizes the Decreased Density of Tyrosine Hydroxylase-Immunoreactive Fibers in the Stomach Caused by Mild Gestational Calorie Restriction

    Directory of Open Access Journals (Sweden)

    Nara Szostaczuk

    2018-03-01

    Full Text Available Introduction: Gestational under nutrition in rats has been shown to decrease expression of sympathetic innervation markers in peripheral tissues of offspring, including the stomach. This has been linked to lower gastric secretion and decreased circulating levels of ghrelin. Considering the critical role of leptin intake during lactation in preventing obesity and reversing adverse developmental programming effects, we aimed to find out whether leptin supplementation may reverse the above mentioned alterations caused by mild gestational calorie restriction.Methods: Three groups of male rats were studied at a juvenile age (25 days old and during adulthood (3 and 6 months old: the offspring of ad libitum fed dams (controls, the offspring of dams that were diet restricted (20% from days 1 to 12 of gestation (CR, and CR rats supplemented with a daily oral dose of leptin (equivalent to 5 times the average amount they could receive each day from maternal milk throughout lactation (CR-Leptin. The density of TyrOH-immunoreactive (TyrOH+ fibers and the levels of Tyrosine hydroxylase (TyrOH—used as potential markers of functional sympathetic innervation—were measured in stomach. Plasma leptin and ghrelin levels were also determined.Results: Twenty five-day-old CR rats, but not CR-Leptin rats, displayed lower density of TyrOH+ fibers (−46% and TyrOH levels (−47% in stomach compared to controls. Alterations in CR animals were mitigated at 6 months of age, and differences were not significant. Adult CR-Leptin animals showed higher plasma ghrelin levels than CR animals, particularly at 3 months (+16%, and a lower leptin/ghrelin ratio (−28 and −37% at 3 and 6 months, respectively.Conclusion: Leptin intake during lactation is able to reverse the alterations in the density of TyrOH+ fibers in the stomach and normalize the increased leptin/ghrelin ratio linked to a mild gestational calorie restriction in rats, supporting the relevance of leptin as an

  11. [Study of genetic variants in the BDNF, COMT, DAT1 and SERT genes in Colombian children with attention deficit disorder].

    Science.gov (United States)

    Ortega-Rojas, Jenny; Arboleda-Bustos, Carlos E; Morales, Luis; Benítez, Bruno A; Beltrán, Diana; Izquierdo, Álvaro; Arboleda, Humberto; Vásquez, Rafael

    Attention deficit and hyperactive disorder (ADHD) is highly prevalent among children in Bogota City. Both genetic and environmental factors play a very important role in the etiology of ADHD. However, to date few studies have addressed the association of genetic variants and ADHD in the Colombian population. To test the genetic association between polymorphisms in the DAT1, HTTLPR, COMT and BDNF genes and ADHD in a sample from Bogota City. We genotyped the most common polymorphisms in DAT1, SERT, COMT and BDNF genes associated with ADHD using conventional PCR followed by restriction fragment length polymorphism (RFLP) in 97 trios recruited in a medical center in Bogota. The transmission disequilibrium test (TDT) was used to determine the association between such genetic variants and ADHD. The TDT analysis showed that no individual allele of any variant studied has a preferential transmission. Our results suggest that the etiology of the ADHD may be complex and involves several genetic factors. Further studies in other candidate polymorphisms in a larger sample size will improve our knowledge of the ADHD in Colombian population. Copyright © 2016 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

  12. PET imaging of the brain serotonin transporters (SERT) with N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM) in humans: a preliminary study

    International Nuclear Information System (INIS)

    Huang, Wen-Sheng; Huang, San-Yuan; Ho, Pei-Shen; Yeh, Chin-Bin; Ma, Kuo-Hsing; Huang, Ya-Yao; Shiue, Chyng-Yann; Liu, Ren-Syuan; Cheng, Cheng-Yi

    2013-01-01

    The aim of this study was to assess the feasibility of using 4-[ 18 F]-ADAM as a brain SERT imaging agent in humans. Enrolled in the study were 19 healthy Taiwanese subjects (11 men, 8 women; age 33 ± 9 years). The PET data were semiquantitatively analyzed and expressed as specific uptake ratios (SUR) and distribution volume ratios (DVR) using the software package PMOD. The SUR and DVR of 4-[ 18 F]-ADAM in the raphe nucleus (RN), midbrain (MB), thalamus (TH), striatum (STR) and prefrontal cortex (PFC) were determined using the cerebellum (CB) as the reference region. 4-[ 18 F]-ADAM bound to known SERT-rich regions in human brain. The order of the regional brain uptake was MB (RN) > TH > STR > PFC > CB. The DVR (n = 4, t* = 60 min) in the RN, TH, STR and PFC were 3.00 ± 0.50, 2.25 ± 0.45, 2.05 ± 0.31 and 1.40 ± 0.13, respectively. The optimal time for imaging brain SERT with 4-[ 18 F]-ADAM was 120-140 min after injection. At the optimal imaging time, the SURs (n = 15) in the MB, TH, STR, and PFC were 2.25 ± 0.20, 2.28 ± 0.20, 2.12 ± 0.18 and 1.47 ± 0.14, respectively. There were no significant differences in SERT availability between men and women (p 18 F]-ADAM was safe for human studies and its distribution in human brain appeared to correlate well with the known distribution of SERT in the human brain. In addition, it had high specific binding and a reasonable optimal time for imaging brain SERT in humans. Thus, 4-[ 18 F]-ADAM may be feasible for assessing the status of brain SERT in humans. (orig.)

  13. PET imaging of the brain serotonin transporters (SERT) with N,N-dimethyl-2-(2-amino-4-[{sup 18}F]fluorophenylthio)benzylamine (4-[{sup 18}F]-ADAM) in humans: a preliminary study

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Wen-Sheng [PET Center, Tri-Service General Hospital, Department of Nuclear Medicine, Neihu, Taipei (China); Changhua Christian Hospital, Department of Nuclear Medicine, Changhua (China); Huang, San-Yuan; Ho, Pei-Shen; Yeh, Chin-Bin [Tri-Service General Hospital, Department of Psychiatry, Taipei (China); Ma, Kuo-Hsing [National Defense Medical Center, Department of Biology and Anatomy, Taipei (China); Huang, Ya-Yao; Shiue, Chyng-Yann [PET Center, Tri-Service General Hospital, Department of Nuclear Medicine, Neihu, Taipei (China); PET Center, National Taiwan University Hospital, Department of Nuclear Medicine, Taipei (China); Liu, Ren-Syuan [Taipei Veterans General Hospital, Department of Nuclear Medicine, Taipei (China); Cheng, Cheng-Yi [PET Center, Tri-Service General Hospital, Department of Nuclear Medicine, Neihu, Taipei (China)

    2013-01-15

    The aim of this study was to assess the feasibility of using 4-[{sup 18}F]-ADAM as a brain SERT imaging agent in humans. Enrolled in the study were 19 healthy Taiwanese subjects (11 men, 8 women; age 33 {+-} 9 years). The PET data were semiquantitatively analyzed and expressed as specific uptake ratios (SUR) and distribution volume ratios (DVR) using the software package PMOD. The SUR and DVR of 4-[{sup 18}F]-ADAM in the raphe nucleus (RN), midbrain (MB), thalamus (TH), striatum (STR) and prefrontal cortex (PFC) were determined using the cerebellum (CB) as the reference region. 4-[{sup 18}F]-ADAM bound to known SERT-rich regions in human brain. The order of the regional brain uptake was MB (RN) > TH > STR > PFC > CB. The DVR (n = 4, t* = 60 min) in the RN, TH, STR and PFC were 3.00 {+-} 0.50, 2.25 {+-} 0.45, 2.05 {+-} 0.31 and 1.40 {+-} 0.13, respectively. The optimal time for imaging brain SERT with 4-[{sup 18}F]-ADAM was 120-140 min after injection. At the optimal imaging time, the SURs (n = 15) in the MB, TH, STR, and PFC were 2.25 {+-} 0.20, 2.28 {+-} 0.20, 2.12 {+-} 0.18 and 1.47 {+-} 0.14, respectively. There were no significant differences in SERT availability between men and women (p < 0.05). The results of this study showed that 4-[{sup 18}F]-ADAM was safe for human studies and its distribution in human brain appeared to correlate well with the known distribution of SERT in the human brain. In addition, it had high specific binding and a reasonable optimal time for imaging brain SERT in humans. Thus, 4-[{sup 18}F]-ADAM may be feasible for assessing the status of brain SERT in humans. (orig.)

  14. Uso e conhecimento tradicional de plantas medicinais no Sertão do Ribeirão, Florianópolis, SC, Brasil Use and traditional knowledge of medicinal plants at Sertão do Ribeirão, Florianópolis, Santa Catarina State, Brazil

    Directory of Open Access Journals (Sweden)

    Mariana Giraldi

    2010-06-01

    Full Text Available O objetivo desta pesquisa foi realizar um estudo etnobotânico sobre o uso e o conhecimento tradicional de plantas medicinais no Sertão do Ribeirão, uma comunidade de origem açoriana, inserida no domínio da Mata Atlântica e localizada dentro dos limites do Parque Municipal da Lagoa do Peri. Foram realizadas 13 entrevistas com moradores do Sertão do Ribeirão, sendo identificadas 114 espécies de plantas medicinais, distribuídas em 48 famílias botânicas. A diversidade de plantas medicinais conhecida no Sertão do Ribeirão é bastante elevada e a obtenção das plantas na própria comunidade sugere uma forte correlação entre uso e conhecimento tradicional de plantas medicinais e a possibilidade de obtê-las no local. O conhecimento etnobotânico sobre plantas medicinais não difere entre homens e mulheres e o uso de medicamentos industrializados e de plantas medicinais indica uma complementaridade entre a medicina moderna e a medicina popular. A transmissão do conhecimento feita na própria comunidade, com pais/avós e vizinhos, demonstra uma rica herança cultural local sobre plantas medicinais.The aim of this research was to do an ethnobotanical study on the use and traditional knowledge of medicinal plants at Sertão do Ribeirão, an Azorean community, inserted in the Atlantic Forest domain and located within the boundaries of Lagoa do Peri Municipal Park. A total of 13 interviews were made with residents of Sertão do Ribeirão, identifying 114 species of medicinal plants, distributed in 48 botanical families. The diversity of medicinal plants known at Sertão do Ribeirão is quite high and the collection of plants by the community suggests a strong correlation between use and traditional knowledge of medicinal plants and the possibility of local gathering. Ethnobotanical knowledge of medicinal plants does not differ between women and men and the use of industrialized medicine and medicinal plants indicates a complementarity

  15. O SABER CAMPONÊS: apropriação dos Recursos no Sertão dos Inhamuns - CE

    Directory of Open Access Journals (Sweden)

    José Levi Furtado Sampaio

    2007-01-01

    Full Text Available Aunque posee orígenes remotos, la cuestión agraria se materializa como un debate persistente en el inicio del siglo XXI. Aun delante de considerables transformaciones económicas, sociales y políticas, lo que se percibe en Brasil y en el mundo es la vitalidad de la lucha por tierra y de la demanda por reforma agraria, vía resistencia y superación de las adversidades puestas a los campesinos. Luego, resultantes tanto de la historia de vida, como de las costumbres, los campesinos expresan sus formas de apropiación por medio de las tradiciones culturales o costumbres campesinas. Ellos lanzan una mirada orientada por las necesidades, sus conocimientos y su saber hacer, para conseguir la soberanía alimentar, superación de los problemas campesinos y resistencia al sistema capitalista. La discusión sobre ese tema en el presente artículo envuelve la comprensión del contexto histórico en el que el campesino está inserido, bien como sus prácticas culturales. Esas reflexiones fueron poco a poco instigando la discusión sobre cómo las costumbres campesinas se reflejan en la apropiación de los recursos en el espacio agrario del asentamiento Ingá/Facundo, ubicado en el municipio de Parambu, Microrregión del Sertón de los Inhamuns, a 371 km de la ciudad de Fortaleza, en Ceará, puesto que tal hecho es elemento fundamental para comprender como se da la resistencia y superación de la cultura campesina delante de las condiciones, por veces, adversas del semiárido cearense.

  16. Presence of sarcopenia in asthma–COPD overlap syndrome may be a risk factor for decreased bone-mineral density, unlike asthma: Korean National Health and Nutrition Examination Survey (KNHANES IV and V (2008–2011

    Directory of Open Access Journals (Sweden)

    Lee DW

    2017-08-01

    Full Text Available Dong-Won Lee,1 Hyun-Jung Jin,2 Kyeong-Cheol Shin,2 Jin-Hong Chung,2 Hyoung-Woo Lee,3 Kwan-Ho Lee2 1Division of Pulmonology, Department of Internal Medicine, Andong Sungso Hospital, Andong, 2Division of Pulmonology and Allergy, 3Division of Endocrinology, Department of Internal Medicine, Yeungnam University Hospital, Daegu, South Korea Background: Sarcopenia and decreased bone-mineral density (BMD are common in elderly people, and are major comorbidities of obstructive airway disease (OAD. However, the relationship between sarcopenia and BMD in each OAD phenotype, especially asthma–COPD overlap syndrome (ACOS, is not yet clear. We aimed to evaluate differences in BMD according to the presence of sarcopenia in each OAD phenotype. Materials and methods: Among the research subjects in KNHANES IV and V (2008–2011, 5,562 were ≥50 years old and underwent qualified spirometry and dual-energy X-ray absorptiometry. A total of 947 subjects were included in the study: 89 had asthma, 748 COPD, and 110 ACOS. Results: In the COPD and ACOS phenotypes, T-scores were lower in the sarcopenia group than the nonsarcopenia group. Prevalence rates of osteopenia and osteoporosis were higher in the sarcopenia group than the nonsarcopenia group. (P<0.001 and P=0.017, respectively. The sarcopenia group had higher risks of developing osteopenia, osteoporosis, and low BMD than the nonsarcopenia group in the ACOS phenotype (OR 6.620, 95% CI 1.129–38.828 [P=0.036], OR 9.611, 95% CI 1.133–81.544 [P=0.038], and OR 6.935, 95% CI 1.194–40.272 [P=0.031], respectively. However, in the asthma phenotype, the sarcopenia group showed no increased risk compared with the nonsarcopenia group. Conclusion: In the ACOS phenotype, individuals with sarcopenia had a higher prevalence rate and higher risks of osteopenia and osteoporosis than those without sarcopenia among all OAD phenotypes. Keywords: asthma, chronic obstructive pulmonary disease, asthma–COPD overlap syndrome

  17. Características clínico-comportamentais de professores . universitários no sertão paraibano

    OpenAIRE

    Coêlho, Raimunda de Fátima Neves

    2013-01-01

    p. 1-153 comprometer a saúde física e mental dos indivíduos é necessária, para respaldar programas de suporte ao docente. O estudo objetivou descrever características clínico-comportamentais de professores universitários no sertão paraibano, tendo como objetivos secundários: avaliar correlação entre Resiliência, História de Trauma, Transtorno do Estresse Pós-traumático - TEPT, Impulsividade, Religiosidade, e Qualidade de Vida na população estudada; determinar a frequência de...

  18. Farklı Canlı Ağırlıklardaki Keçilerden Elde Edilen Çiğ Sütlerin Sert, Yarı Sert ve Yumuşak Peynir Üretim Standartlarına Uygunluklarının Belirlenmesi

    OpenAIRE

    Çimen, Murat; Topçu, Hakan; Ölcal, Mehmet Cengiz

    2013-01-01

    Bu araştırmanın amacı farklı canlı ağırlıklara sahip keçilerden elde edilen çiğ sütlerin sert, yarı sert ve sert peynir standartlarına göre uygunluğunu araştırmaktır. Veriler Tunceli ilinin İsmailli köyünde yetiştirilen bir Saanen keçi sürüsünden elde edilmiştir. Ağır ve hafif keçiler için sütteki toplam yağ seviyeleri yumuşak peynir üretimi için bildirilen standartlara uygun bulunmuştur. Her iki gruptaki (ağır ve hafif) toplam kurumadde ve protein oranları üç peynir çeşidi (yumuşak, yarı ser...

  19. Presence of sarcopenia in asthma-COPD overlap syndrome may be a risk factor for decreased bone-mineral density, unlike asthma: Korean National Health and Nutrition Examination Survey (KNHANES) IV and V (2008-2011).

    Science.gov (United States)

    Lee, Dong-Won; Jin, Hyun-Jung; Shin, Kyeong-Cheol; Chung, Jin-Hong; Lee, Hyoung-Woo; Lee, Kwan-Ho

    2017-01-01

    Sarcopenia and decreased bone-mineral density (BMD) are common in elderly people, and are major comorbidities of obstructive airway disease (OAD). However, the relationship between sarcopenia and BMD in each OAD phenotype, especially asthma-COPD overlap syndrome (ACOS), is not yet clear. We aimed to evaluate differences in BMD according to the presence of sarcopenia in each OAD phenotype. Among the research subjects in KNHANES IV and V (2008-2011), 5,562 were ≥50 years old and underwent qualified spirometry and dual-energy X-ray absorptiometry. A total of 947 subjects were included in the study: 89 had asthma, 748 COPD, and 110 ACOS. In the COPD and ACOS phenotypes, T-scores were lower in the sarcopenia group than the nonsarcopenia group. Prevalence rates of osteopenia and osteoporosis were higher in the sarcopenia group than the nonsarcopenia group. ( P sarcopenia group had higher risks of developing osteopenia, osteoporosis, and low BMD than the nonsarcopenia group in the ACOS phenotype (OR 6.620, 95% CI 1.129-38.828 [ P =0.036], OR 9.611, 95% CI 1.133-81.544 [ P =0.038], and OR 6.935, 95% CI 1.194-40.272 [ P =0.031], respectively). However, in the asthma phenotype, the sarcopenia group showed no increased risk compared with the nonsarcopenia group. In the ACOS phenotype, individuals with sarcopenia had a higher prevalence rate and higher risks of osteopenia and osteoporosis than those without sarcopenia among all OAD phenotypes.

  20. Dieta de Leptodactylus macrosternum (Amphibia; Anura; Leptodactylidae no Sertão da Paraíba, Brasil

    Directory of Open Access Journals (Sweden)

    Dyego Francisco Silva da Costa

    2016-11-01

    Full Text Available Entender a ecologia alimentar de anuros é essencial para compreender a biologia de vida destes animais. Essas informações fornecem dados necessários sobre seu habitat, morfologia, fisiologia e comportamento. Nesse sentido objetivou-se analisar a dieta de uma população Leptodactylus macrosternum, da fazenda Cajueiro, município de Catolé do Rocha, Sertão paraibano. As coletas ocorreram mensalmente entre os meses de outubro de 2013 e junho de 2014, realizadas por meio de busca ativa auditiva/visual. Em laboratório, verificou- se os conteúdos alimentares até o nível taxonômico de Ordem. Foram identificadas 10 categorias alimentares, sendo sete pertencentes à classe Insecta, duas Arachinida e uma Gasthropoda, além de vegetais e terra/pedra. Os principais itens alimentares na dieta, segundo o Índice de Importância Alimentar, foram Coleoptera e Hymenoptera, seguidos de Odonata, Hemiptera e Orthoptera, não ocorrendo de modo geral modificações significativas no consumo dos itens alimentares. As alterações no consumo dos itens na dieta de L. macrosternum, possivelmente resultam da disponibilidade, associada a variações pluviométricas da região. Diet of Leptodactylus macrosternum (Amphibia Anura: Leptodactylidae in the backlands of Paraiba, BrazilAbstract: Understanding the frogs food ecology is essential to understand the biology of life of these animals. This information provides necessary data on their habitat, morphology, physiology and behavior. In the study we analyzed the diet of a Leptodactylus macrosternum population, of the farm Cajueiro, city of Catolé do Rocha, wilderness region of Paraíba. The gatherings were executed between October of 2013 and June of 2014, by hearing/visual active search. In the laboratory, the food contents were analyzed in the taxonomic categories of Order. Were identified 10 feeding categories, being 7 belonging to the class Insecta, 2 Arachinida, 1 Gasthropoda, in addition to vegetables and

  1. O livro que abalou o Brasil: a consagração de Os sertões na virada do século The book that shook Brazil: the acclaim of Os sertões at the turn of the century

    Directory of Open Access Journals (Sweden)

    Regina Abreu

    1998-07-01

    Full Text Available Como e por que Os sertões de Euclides da Cunha transformaram-se no maior best-seller da virada do século? De que modo esse livro abalou o Brasil, modificando valores e pontos de vista sobre o próprio país. Para responder a essas indagações, a autora analisa as críticas consagradoras de José Veríssimo, Araripe Júnior e Sílvio Romero, responsáveis pela transformação de um anônimo engenheiro no mais festejado escritor da capital federal. Quem eram e o que diziam esses críticos? Que valores foram afirmados com a consagração de Os sertões? Em que direção foi reiterado um ponto de vista singular sobre o Brasil? Que ponto de vista era esse? Tomando as críticas como referência, a autora procura desvendar o significado social da novidade advinda com a publicação de Os sertões, chamando a atenção para o que havia de promissor no olhar do escritor sobre a tragédia de Canudos.How and why did Euclides da Cunha’s Os sertões become the number one best-seller in Brazil at the dawn of the 20th century? How did this book shake Brazil at that time, altering values and viewpoints about the country itself? To answer these questions, the article analyzes reviews by José Veríssimo, Araripe Júnior, and Sílvio Romero, responsible for turning an anonymous engineer into the most celebrated author in the nation’s capital. Who were these critics? What did they have to say? What values were affirmed through this acclamation of Os sertões? What view of Brazil was defended? Using these acclamatory reviews as a central reference point, the article seeks to uncover the social significance of the new ideas found in Cunha’s book and call attention to the fertile and promising aspects found in this writer’s interpretation of the Canudos tragedy.

  2. Sheep gastrointestinal helminthiasis in the Sertão region of Paraíba State, Northeastern Brazil: prevalence and risk factors.

    Science.gov (United States)

    Vieira, Vanessa Diniz; Vilela, Vinícius Longo Ribeiro; Feitosa, Thais Ferreira; Athayde, Ana Célia Rodrigues; Azevedo, Sérgio Santos; Souto, Diego Vagner de Oliveira; Silveira, Gian Libânio da; Melo, Lídio Ricardo Bezerra de

    2014-01-01

    In this study, we aimed to establish the prevalence and risk factors relating to gastrointestinal helminthiasis, and to characterize the sanitary management practiced among sheep herds in the Sertão region of the state of Paraíba, northeastern Brazil, based on factors that condition the ways of controlling these parasites in these herds. The research was carried out between April and July 2012. We visited 54 farms, where fecal and blood samples were individually collected from 465 animals. On each farm, a questionnaire was applied to gather information on variables relating to potential risk factors. The prevalence of sheep gastrointestinal helminthiasis in the region was 75.9%. At least one animal tested positive for this helminthiasis on 53 (98.1%) of the 54 farms evaluated. The eggs per gram of feces (EPG) analysis showed the following infection burdens: 51.8% with mild infection, 27.1% moderate infection, 9.9% heavy infection and 11.2% fatal infection. Among the sheep farms visited, anthelmintics were used on 81.5% (p helminthiasis, because the animals are more prone to reinfection. The Sertão region of Paraíba presents high prevalence of gastrointestinal helminthiasis among sheep, and the farm area is the most relevant risk factor for the development of these parasites.

  3. SERT and TPH-1 mRNA expression are reduced in irritable bowel syndrome patients regardless of visceral sensitivity state in large intestine.

    Science.gov (United States)

    Kerckhoffs, Angèle P M; ter Linde, José J M; Akkermans, Louis M A; Samsom, Melvin

    2012-05-01

    Colorectal visceral hypersensitivity has been demonstrated in a subset of irritable bowel syndrome (IBS) patients. Serine protease and serotonergic signaling modulate gastrointestinal visceral sensitivity. We evaluated whether altered mucosal serine protease and serotonergic pathway components are related to rectal visceral hypersensitivity in IBS patients. Colorectal mucosal biopsies of 23 IBS patients and 15 controls were collected. Gene transcripts of protease-activated receptor (PAR)-2, trypsinogen IV, tryptophan hydroxylase (TPH)-1, and serotonin reuptake transporter (SERT) were quantified using real-time polymerase chain reaction. Substance P and 5-HT contents were measured by ELISA. The number of enterochromaffin cells, mast cells, and intraepithelial lymphocytes was determined using immunohistochemistry. Rectal visceral sensitivity was determined in IBS patients using barostat programmed for phasic ascending distension. Rectal hypersensitivity (+) and (-) IBS patients showed lower TPH-1 and SERT mRNA levels in the rectum compared with controls (P ≤ 0.05). Rectal hypersensitivity (+) IBS patients (n = 12) showed lower TPH-1 mRNA level in the sigmoid compared with controls (P = 0.015). No significant differences were observed in PAR-2 and trypsinogen IV expression between controls and IBS patients. Rectal substance P content was increased in IBS patients compared with controls (P = 0.045). No significant differences were found in transcript levels, cell counts, and substance P and 5-HT contents between rectal hypersensitivity (+) and (-) IBS patients. In conclusion, regardless of visceral hypersensitivity state, several serotonergic signaling components are altered in IBS patients.

  4. Beneficiamento do cultivo do Meloeiro pela apicultura no sertão do Moxotó representado por Modelo Digital do Terreno | Processing of Melon crops for beekeeping in the backwoods of Moxotó represented by Digital Terrain Model

    Directory of Open Access Journals (Sweden)

    Raphael Miller de Souza Caldas

    2016-04-01

    Full Text Available A região Nordeste é a principal produtora de melão do Brasil. O Semiárido brasileiro é uma região caracterizada por apresentar fatores climáticos favoráveis ao desenvolvimento da cultura do meloeiro. No presente estudo foi realizada a modelagem digital do terreno (MDT da microrregião Sertão do Moxotó para os parâmetros de precipitação, temperatura, PIB e IDH, afim de verificar a relação entre a cultura do meloeiro e a apicultura. Os municípios analisados foram Arcoverde, Betânia, Custódia, Ibimirim, Inajá, Sertânia e Manari. O cultivo do meloeiro tem potencial para ser implantado nos municípios do Sertão do Moxotó e está diretamente ligado a apicultura, pois a Apis mellifera é seu principal polinizador. Seu cultivo pode desempenhar papel vital no aumento ou manutenção da produção apícola. The Northeast region is the main melon producer of Brazil. The Brazilian semiarid region is characterized by climatic conditions favorable to the development of melon crop. In the present study, the digital terrain modeling (DTM of Sertão do Moxotó was performed to precipitation parameters, temperature, GDP, HDI and population in order to verifythe relationship between melon crop and apiculture. The districts analyzed were Arcoverde, Betânia, Custódia, Ibimirim, Inajá, Sertânia and Manari. Apis mellifera is the main pollinator of melon crop. Melon crop can support the bees during the shortage of bee flora and increase in bee production.

  5. A universalidade em grande sertão: veredas e a noção de gramatica universaL

    Directory of Open Access Journals (Sweden)

    Lorenzo VITRAL

    2009-07-01

    Full Text Available Este artigo propõe uma reflexão sobre a sintaxe criada por Guimarães Rosa na sua obra-prima Grande sertão: veredas, Admite-se normalmente que sua linguagem utiliza volteios e estruturas provenientes de línguas estrangeiras, de certos dialetos falados do português do Brasil e de estágios históricos do português, Propomos que esses recursos são tão-somente elementos que incitam mecanismos da Gramática Universal, isto é, a entidade teórica proposta na teoria da Gramática Gerativa.

  6. A universalidade em grande sertão: veredas e a noção de gramatica universaL

    Directory of Open Access Journals (Sweden)

    Lorenzo VITRAL

    2013-11-01

    Full Text Available Este artigo propõe uma reflexão sobre a sintaxe criada por Guimarães Rosa na sua obra-prima Grande sertão: veredas, Admite-se normalmente que sua linguagem utiliza volteios e estruturas provenientes de línguas estrangeiras, de certos dialetos falados do português do Brasil e de estágios históricos do português, Propomos que esses recursos são tão-somente elementos que incitam mecanismos da Gramática Universal, isto é, a entidade teórica proposta na teoria da Gramática Gerativa.

  7. Guimarães Rosa, colecionador de palavras – uma leitura da poética das listas, em Grande sertão: veredas

    Directory of Open Access Journals (Sweden)

    Ivana Ferrante Rebello

    2017-05-01

    Full Text Available A escrita de Grande sertão: veredas, de Guimarães Rosa, apresenta uma série de listas, superpostas, que contribuem para conferir ao romance movimento e musicalidade. A partir das reflexões de Umberto Eco, em A vertigem das listas (2010, este artigo analisa o efeito poético das listas que compõem a escrita do romance. Enumerações de palavras, ditos populares, nomes de plantas e animais compõem as listas que estão presentes nas cadernetas do autor. Essas listas, que serviram de suporte à escrita inventiva do autor, também aparecem de forma abundante em sua ficção. Propomos, no presente estudo, uma reflexão acerca das imagens, da musicalidade e do ritmo que as listas superpostas conferem ao romance.

  8. Rosa em policromia: cores, eros e íris (um arco de sexualidade entre Magma e Grande sertão: veredas

    Directory of Open Access Journals (Sweden)

    Wilberth Clayton Ferreira Salgueiro

    2005-10-01

    Full Text Available Numa  passagem de Grande sertão: veredas,  Riobaldo fala de uma "sonhice" que teve: "Diadorim  passando por debaixo do a rco-íris". Vinte anos antes,  em Magma,  Rosa esc reveu  um con junto de sete poemas, cujos  títu los  denunciam  a presen ça do arco-íris  e ativam sentidos que tal fenômeno carrega. Entender alguns destes sentidos, mostrando como as cores funcionam  na vida e na lite ratura, é o que quer o prese nte artigo. Para isso, analisam-se o poema "Ve rmelho" e a referida passagem-sonho como indicadores de um pensamento sobre a sexualidade.

  9. Deletion of the Intestinal Plasma Membrane Calcium Pump, Isoform 1, Atp2b1, in Mice is Associated with Decreased Bone Mineral Density and Impaired Responsiveness to 1, 25-Dihydroxyvitamin D3

    Science.gov (United States)

    Ryan, Zachary C.; Craig, Theodore A.; Filoteo, Adelaida G.; Westendorf, Jennifer J.; Cartwright, Elizabeth J.; Neyses, Ludwig; Strehler, Emanuel E.; Kumar, Rajiv

    2016-01-01

    The physiological importance of the intestinal plasma membrane calcium pump, isoform 1, (Pmca1, Atp2b1), in calcium absorption and homeostasis has not been previously demonstrated in vivo. Since global germ-line deletion of the Pmca1 in mice is associated with embryonic lethality, we selectively deleted the Pmca1 in intestinal absorptive cells. Mice with loxP sites flanking exon 2 of the Pmca1 gene (Pmca1fl/fl) were crossed with mice expressing Cre recombinase in the intestine under control of the villin promoter to give mice in which the Pmca1 had been deleted in the intestine (Pmca1EKO mice). Pmca1EKO mice were born at a reduced frequency and were small at the time of birth when compared to wild-type (Wt) litter mates. At two months of age, Pmca1EKO mice fed a 0.81% calcium, 0.34% phosphorus, normal vitamin D diet had reduced whole body bone mineral density (P <0.037), and reduced femoral bone mineral density (P <0.015). There was a trend towards lower serum calcium and higher serum parathyroid hormone (PTH) and 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) concentrations in Pmca1EKO mice compared to Wt mice but the changes were not statistically significant. The urinary phosphorus/creatinine ratio was increased in Pmca1EKO mice (P <0.004). Following the administration of 200 ng of 1α,25(OH)2D3 intraperitoneally to Wt mice, active intestinal calcium transport increased ∼2-fold, whereas Pmca1EKO mice administered an equal amount of 1α,25(OH)2D3 failed to show an increase in active calcium transport. Deletion of the Pmca1 in the intestine is associated with reduced growth and bone mineralization, and a failure to up-regulate calcium absorption in response to 1α,25(OH)2D3. PMID:26392310

  10. Serotonin transporter density in binge eating disorder and pathological gambling: A PET study with [11C]MADAM.

    Science.gov (United States)

    Majuri, Joonas; Joutsa, Juho; Johansson, Jarkko; Voon, Valerie; Parkkola, Riitta; Alho, Hannu; Arponen, Eveliina; Kaasinen, Valtteri

    2017-12-01

    Behavioral addictions, such as pathological gambling (PG) and binge eating disorder (BED), appear to be associated with specific changes in brain dopamine and opioid function, but the role of other neurotransmitter systems is less clear. Given the crucial role of serotonin in a number of psychiatric disorders, we aimed to compare brain serotonergic function among individuals with BED, PG and healthy controls. Seven BED patients, 13 PG patients and 16 healthy controls were scanned with high-resolution positron emission tomography (PET) using the serotonin transporter (SERT) tracer [ 11 C]MADAM. Both region-of-interest and voxel-wise whole brain analyses were performed. Patients with BED showed increased SERT binding in the parieto-occipital cortical regions compared to both PG and healthy controls, with parallel decreases in binding in the nucleus accumbens, inferior temporal gyrus and lateral orbitofrontal cortex. No differences between PG patients and controls were observed. None of the subjects were on SSRI medications at the time of imaging, and there were no differences in the level of depression between PG and BED patients. The results highlight differences in brain SERT binding between individuals with BED and PG and provide further evidence of different neurobiological underpinnings in behavioral addictions that are unrelated to the co-existing mood disorder. The results aid in the conceptualization of behavioral addictions by characterizing the underlying serotonin changes and provide a framework for additional studies to examine syndrome-specific pharmaceutical treatments. Copyright © 2017 Elsevier B.V. and ECNP. All rights reserved.

  11. Soroprevalência e fatores de risco para a língua azul em carneiros das mesorregiões do Sertão e da Borborema, semi-árido do Estado da Paraíba, Brasil Seroprevalence and risk factors for Bluetongue in rams of the Sertão and Borborema mesoregions, semi-arid of Paraíba state, Northeastern Brazil

    Directory of Open Access Journals (Sweden)

    Francisco de Assis Leandro Alves

    2009-04-01

    Full Text Available Neste estudo foi determinada a prevalência de anticorpos contra o vírus da língua azul em carneiros das mesorregiões do Sertão e da Borborema, semi-árido do Estado da Paraíba, bem como foram identificados os fatores de risco associados à infecção. A amostragem foi delineada para a determinação da prevalência de propriedades positivas (focos e de animais soropositivos por mesorregião. Foi realizada uma seleção aleatória de unidades primárias, composta por 189 propriedades no Sertão e 100 propriedades na Borborema. Dentro das unidades primárias, foram amostrados todos os carneiros (unidades secundárias, resultando em 321 animais no Sertão e 185 na Borborema. Na ocasião da coleta, foi aplicado um questionário epidemiológico por propriedade. Para o diagnóstico sorológico, foi utilizada a prova de imunodifusão em gel de ágar (IDGA, com antígeno produzido na Escola de Veterinária da Universidade Federal de Minas Gerais. Uma propriedade foi considerada foco quando apresentou pelo menos um animal soropositivo. Na mesorregião do Sertão, as prevalências de focos e de animais soropositivos foram de 11,6% [7,8% - 17,1%] e 8,4% [5,7% - 12,3%], respectivamente. Na mesorregião da Borborema, a prevalência de focos foi de 0,0% [0,0% - 3,6%] e a prevalência de animais soropositivos foi de 0,0% [0,0% - 2,0%]. Os fatores de risco associados à língua azul foram a não realização de higiene das instalações (OR = 5,51 e a vermifugação dos animais duas a quatro vezes ao ano (OR = 4,44.The prevalence of antibodies against Bluetongue virus in rams of the Sertão and Borborema mesoregions, semi-arid of the Paraíba state, Northeastern Brazil, was determined, and risk factors for the infection were identified. The sampling was delineated for the determination of the prevalence of positive herds and seropositive animals for each mesoregion. Herds (primary units were randomly selected in the Sertão mesoregion (n = 189 and in the

  12. O Judiciário e a aplicação da função social da propriedade na preservação da caatinga no sertão do Pajeú

    Directory of Open Access Journals (Sweden)

    Fernando Joaquim Ferreira Maia

    2013-02-01

    Full Text Available Neste trabalho será sustentado que as decisões judiciais, acerca da desapropriação para fins de reforma agrária, devem levar em consideração a preservação ambiental da caatinga no Sertão do Pajeú e partir de um entendimento efetivo da aplicação da função social da propriedade. Utiliza-se, como parâmetros, as sentenças judiciais proferidas nos autos dos processos de desapropriação para fins de reforma agrária das Fazendas FAGUSA e Socorro, a primeira localizada no Município de Serra Talhada e a segunda no Município de Afogados da Ingazeira, ambos situados no Estado de Pernambuco. Distingue-se a degradação da caatinga no Sertão do Pajeú e a relação com a função social da propriedade e o bem ambiental. Defende-se a reforma agrária como instrumento de realização da função social da propriedade na proteção do meio ambiente e como base retórica para dar efetividade e pertinência ao discurso judicial de preservação da caatinga no Sertão do Pajeú pernambucano.

  13. Topofobia e topofilia em “A Terra”, de “Os Sertões”: uma análise ecocrítica do espaço sertanejo euclidiano / Topophobia and topophilia in”The Land” of “Os Sertões”: Analysis ecocriticism of space Sertanejo Euclideano

    Directory of Open Access Journals (Sweden)

    Edilane Ferreira da Silva

    2014-08-01

    Full Text Available In 1902, the journalist Euclides da Cunha published the work Os Sertões which, starting Pre-Brazilian Modernism and enhance Bahia´s backlands from the Canudos War. We analyze the chapter “The Earth” of the Euclidean book, in order to examine the discourse method analysis and the ecocriticism perspective - which concerns the interactions between literature and ecology - the author approaches between the backwoods and wilderness, and his own feelings regarding this space, considering topophobia concepts - aversion to physical environment and topophilia - familiarity or attachment, proposed by the chinese geographer Yi-Fu Tuan and related humanistic geography. Thus, the present discourse in the narrative demonstrate predominance of dislikes and horror feelings for the caatinga, regarding the subjectivity of the writer and oikos referenced by him.

  14. “I seek to shock and surprise the reader” Grande Sertão: Veredas – the poetics of creation and translation

    Directory of Open Access Journals (Sweden)

    Berthold Zilly

    2017-12-01

    Full Text Available This article, motivated by my project of a new German translation of Grande Sertão: Veredas, by João Guimarães Rosa, examines the source text in view of real and possible strategies in foreign language translations, which  are part of the critical fortune and, at the same time, an interpretation tool, since translating allows a privileged hermeneutic approach, by tracking, revealing and trying to reconfigure the "manner of meaning" (Benjamin of a text, its "logic of being-produced" (Adorno, and its "shaping operations" (Haroldo de Campos. For Rosa, the poetics of creation must guide the poetics of translation, aiming at systematic deviation of the standard language, regarding musicality, elliptical composition, effects of shock, defamiliarization, mystery and suggestiveness. A comparative microanalysis of six phrases from the beginning of the novel in nine translations allows us to make the hypothesis that for the last 50 years there has been a certain reorientation from assimilation and domestication strategies towards defamiliarization and foreignization strategies, some which are closer to the intentions of the author and the text itself.

  15. A afirmação da cultura brasileira: dos sertões da Bahia às metamorfoses de casasgrandes e de senzalas

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    Afrânio Garcia Jr

    2009-12-01

    Full Text Available This article investigates the contributions of intellectuals to the valorization of the Brazilian community during the years 1930-1940; substituting the objectivation of the heavy historical legacy inherited from the slavery system of large colonial plantations to the study of a miscigenated population. First, this article reviews the book Os Sertões by Euclides da Cunha, where the signification of the war against the Canudos village is deciphered in terms of elimination of an emerging race resulting from the cross-breeding of the Whites and the Indians. Then the study of three of the main works of the years 30-40, Casa Grande e Senzala (Masters and Slaves by Gilberto Freyre, Raízes do Brasil (Brazil’ Roots by Sérgio Buarque de Hollanda and Formação do Brasil Contemporâneo (The making of contemporary Brazil by Caio Prado Jr. intends to explain how the social matrix of miscegenation in Brazil and the strong legacy of the slavery system having imprinted the ways of functioning of the political space, the economic field and the rebuilding of social hierarchies have been objectified. The author thus explicits the challenges the nation has to face in order to preserve itself and to build the future.

  16. Gestão interfederativa do SUS: a experiência gerencial do Consórcio Intermunicipal do Sertão do Araripe de Pernambuco

    Directory of Open Access Journals (Sweden)

    Jadson Mendonça Galindo

    2014-12-01

    Full Text Available O objetivo deste artigo foi analisar a experiência gerencial do Consórcio Intermunicipal de Saúde do Sertão do Araripe de Pernambuco (Cisape. Para isso, utilizou-se uma pesquisa qualitativa do tipo análise documental. Os documentos analisados foram relatórios produzidos por consultoria especializada, envolvida na implantação da gestão regionalizada e consorciada do Sistema Único de Saúde (SUS em Pernambuco, no período de 2009 e 2010. Os resultados apontam que o Cisape adotou o modelo de gestão gerencialista, ou seja, orientado pela gestão pública pós-burocrática. A estrutura organizacional do Cisape foi definida como de direito público de natureza autárquica. A pesquisa identificou que em Pernambuco o Cisape se configurou como uma ferramenta importante para estimular a regionalização do SUS, porém com incipiente participação social.

  17. Analysis of social and environmental practices related to conscious consumption of students from public education of Sertão Pernambucano, Brazil

    Directory of Open Access Journals (Sweden)

    Anna Fernanda Beatriz Amorim Cavalcante

    2017-11-01

    Full Text Available This research aimed to analyze socio-environmental practices related to the conscious consumption of students of Sertão Pernambucano. A total of 174 high school students from two public schools were interviewed through a 29-item Likert-type measurement scale with five response levels. Among the students, 62.4% were female and 37.6% were male, aged between 15 and 20 years. It was found that 5.8% of the students were careful to take into account if the product residues were recyclable, 40.0% showed indifference or little commitment to use as few shopping bags as possible and the minority (8.3% of the students used to separate the waste by categories. 47.9% of the students affirmed to reuse draft paper and 55.9% save gift paper for future packaging. Few have the habit of watching (24.8%, talking to friends (12.9% or alerting people (23.2% about environmental problems or news. Therefore, Environmental Education, particularly, habits related to conscious consumption, needs to be inserted in the school context so that socio-educational actions become a daily practice, improving the expectations of future generations.

  18. Rocket flight of a multilayer coated high-density EUV toroidal grating

    Science.gov (United States)

    Keski-Kuha, Ritva A. M.; Thomas, Roger J.; Davila, Joseph M.

    1992-01-01

    A multilayer coated high density toroidal grating was flown on a sounding rocket experiment in the Solar EUV Rocket Telescope and Spectrograph (SERTS) instrument. To our knowledge this is the first space flight of a multilayer coated grating. Pre-flight performance evaluation showed that the application of a 10-layer Ir/Si multilayer coating to the 3600 l/mm blazed toroidal replica grating produced a factor of 9 enhancement in peak efficiency near the design wavelength around 30 nm in first order over the standard gold coating, with a measured EUV efficiency that peaked at 3.3 percent. In addition, the grating's spectral resolution of better than 5000 was maintained. The region of enhanced grating efficiency due to the multilayer coating is clearly evident in the flight data. Within the bandpass of the multilayer coating, the recorded film densities were roughly equivalent to those obtained with a factor of six longer exposure on the previous flight of the SERTS instrument.

  19. The Influence of Decreased Levels of High Density Lipoprotein ...

    African Journals Online (AJOL)

    intervention, management, and follow-up of patients. Studies have shown .... for about 4 months prior to blood sample collection. A total of. 56 subjects who ... and types of crisis, presence or absence of Pneumococcal infection, major organs ...

  20. Antes das Minas Gerais: conquista e ocupação dos sertões mineiros Before Minas Gerais: conquest and occupation of the captaincy's hinterland

    Directory of Open Access Journals (Sweden)

    Angelo Alves Carrara

    2007-12-01

    Full Text Available Neste artigo passa-se em revista a história da conquista e ocupação das terras do vale do São Francisco, cuja trama há quase um século adquiriu sua versão definitiva na historiografia tradicional, em vários capítulos a respeito a da "expansão geográfica", como em Basílio de Magalhães; ou b da "história territorial", por Felisbelo Freire; ou c dos "caminhos antigos e povoamento do Brasil", como em Capistrano de Abreu, autor que, se não o primeiro, sem dúvida foi o que mais influiu na tessitura do enredo. Aqui, contudo, os objetivos são distintos, apesar de suas fontes arquivísticas permanecerem inescapavelmente as mesmas. Parte-se do pressuposto de que, na segunda metade do século XVII, encerrou-se o processo de conquista do território às tribos indígenas estabelecidas na margem direita do alto-médio São Francisco. Sob esta perspectiva, ao invés de repetir, mais uma vez, a história das expedições ao interior do Brasil, o que aqui se busca é encontrar o lugar que estas expedições ocuparam nesse processo de conquista e ocupação territorial, que logo em seguida tornaram possível a articulação, tanto da costa com os sertões, quanto dos diferentes sertões entre si.This article aims at reviewing the history of the conquest and occupation of the San Francisco river valley, in Minas Gerais. The definite version of which was established more than a century ago, in several chapters concerning a the geographical expansion, as named by Basílio de Magalhaes; or b the territorial history, by Felisbelo Freire; or c the ancient routes and settlement of Brazil, as in Capistrano de Abreu. Here, meanwhile, the objectives are quite different, despite their archival sources be inescapably the same. It is assumed that in the second half of the sixteenth century the process of conquest of the territories occupied by indian tribes settled in the right bank of the San Francisco river had come to an end. Under this prospect, in spite

  1. Comportamento higiênico em colmeias de Apis mellifera L. africanizadas no Sertão da Paraíba

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    F. A. Olinto

    2015-12-01

    Full Text Available A apicultura é uma das poucas atividades agropecuárias que atende aos três requisitos da sustentabilidade: o econômico, o social e o ecológico. Sendo assim, fornece renda para o apicultor, ocupa mão de obra familiar ou contratada e contribui para a preservação da flora nativa. A sanidade pode afetar o desenvolvimento da apicultura, pois a Apis mellifera como qualquer outro organismo vivo, é susceptível a doenças causadas por bactérias, vírus, fungos e outros parasitas e as desordens metabólicas, nutricionais e hormonais, além de intoxicações diversas. Assim, em virtude da necessidade de estudos a respeito da sanidade apícola, objetiva-se estudar o comportamento higiênico em colônias de abelhas Apis mellifera em apiários localizados no Sertão do Estado da Paraíba. A pesquisa foi realizada no período de março, abril e maio de 2014, em cinco apiários localizados nos municípios de Condado, Pombal, Jericó, São Bentinho e São Domingos, ambos situados na Mesorregião do Sertão do Estado da Paraíba, com um total de 25 colmeias avaliadas. O teste de comportamento higiênico foi realizado com base no método de perfuração das células de crias. O percentual de comportamento higiênico foi semelhante em ambos os apiários, principalmente em Condado (93,96%, Pombal (94,30%, Jericó (87,63% e São Domingos (95,20%, ocorrendo apenas uma ligeira diferença no apiário de São Bentinho com uma média de 76,31%. O apiário localizado no município de Pombal obteve o melhor resultado, apresentando índice elevado de comportamento higiênico. Hygienic behavior in Apis mellifera L. africanized hives in the Backlands of ParaibaAbstract: Beekeeping is one of the few agricultural activities that meets the three requirements of sustainability: economic, social and ecological. Therefore, provides income for the beekeeper, occupies family labor or hired and contributes to the preservation of native flora. Sanity may affect the

  2. Road density

    Data.gov (United States)

    U.S. Environmental Protection Agency — Road density is generally highly correlated with amount of developed land cover. High road densities usually indicate high levels of ecological disturbance. More...

  3. High Spatial Resolution Visual Band Imagery Outperforms Medium Resolution Spectral Imagery for Ecosystem Assessment in the Semi-Arid Brazilian Sertão

    Directory of Open Access Journals (Sweden)

    Ran Goldblatt

    2017-12-01

    Full Text Available Semi-arid ecosystems play a key role in global agricultural production, seasonal carbon cycle dynamics, and longer-run climate change. Because semi-arid landscapes are heterogeneous and often sparsely vegetated, repeated and large-scale ecosystem assessments of these regions have to date been impossible. Here, we assess the potential of high-spatial resolution visible band imagery for semi-arid ecosystem mapping. We use WorldView satellite imagery at 0.3–0.5 m resolution to develop a reference data set of nearly 10,000 labeled examples of three classes—trees, shrubs/grasses, and bare land—across 1000 km 2 of the semi-arid Sertão region of northeast Brazil. Using Google Earth Engine, we show that classification with low-spectral but high-spatial resolution input (WorldView outperforms classification with the full spectral information available from Landsat 30 m resolution imagery as input. Classification with high spatial resolution input improves detection of sparse vegetation and distinction between trees and seasonal shrubs and grasses, two features which are lost at coarser spatial (but higher spectral resolution input. Our total tree cover estimates for the study area disagree with recent estimates using other methods that may underestimate treecover because they confuse trees with seasonal vegetation (shrubs and grasses. This distinction is important for monitoring seasonal and long-run carbon cycle and ecosystem health. Our results suggest that newer remote sensing products that promise high frequency global coverage at high spatial but lower spectral resolution may offer new possibilities for direct monitoring of the world’s semi-arid ecosystems, and we provide methods that could be scaled to do so.

  4. Ocorrência de patógenos em cultivos de melancia e abóbora no sertão da Paraíba

    Directory of Open Access Journals (Sweden)

    M. G. F. O. Soares

    2016-01-01

    Full Text Available Por constituírem uma importante fonte de alimento, plantações de melancia e abóbora são comumente cultivadas no sertão paraibano, porém pouco se sabe sobre a ocorrência de patógenos causadores de doenças, os quais limitam a sua produtividade e renda aos produtores. Visando obter informações sobre a ocorrência dos patógenos virais e fúngicos em cultivos de abóbora e melancia situados em municípios produtores no sertão da Paraíba, amostras coletadas com sintomas de mosaico e deformação foliar, típicos de doenças virais foram analisadas pela técnica sorológica “enzime linked immuno sorbentassay” (Elisa indireto para Papaya ring spot virus, type watermelon (PRSV-W, Watermelon mosaic virus (WMV, Zucchini yellow mosaic virus (ZYMV e Cucumber mosaic virus (CMV. O teste de dupla difusão em Agar foi utilizado para verificar a presença de Squash mosaic virus (SqMV. Em contrapartida, amostras coletadas com sintomas de doenças fúngicas foram analisadas pelo isolamento do patógeno e visualização de suas características morfológicas em microscópio óptico. Em abóbora, houve prevalência dos vírus ZYMV e PRSV-W em infecções simples e mistas, e maior incidência dos fungos Cladosporium spp., e Alternaria spp. Em melancia detectou-se infecção simples e mistas das espécies PRSV-W, WMV e ZYMV, e maior freqüência de Fusarium spp. e Alternaria spp.. Não foram detectados os vírus CMV e SqMV. Os resultados obtidos revelam a ocorrência de vários patógenos fúngicos e viróticos em cultivos de abóbora e melancia situados no sertão da Paraíba e ressaltam a importância da utilização de estratégias de manejo que reduzem os danos ocasionados por esses patógenos.Occurrence of pathogens in watermelon and pumpkin crops in the State of ParaibaAbstract: By constitute an important food source, watermelon and pumpkin plantations are commonly grown on Paraíba backlands, but little is known about the occurrence of disease

  5. Decreasing Relative Risk Premium

    DEFF Research Database (Denmark)

    Hansen, Frank

    relative risk premium in the small implies decreasing relative risk premium in the large, and decreasing relative risk premium everywhere implies risk aversion. We finally show that preferences with decreasing relative risk premium may be equivalently expressed in terms of certain preferences on risky......We consider the risk premium demanded by a decision maker with wealth x in order to be indifferent between obtaining a new level of wealth y1 with certainty, or to participate in a lottery which either results in unchanged present wealth or a level of wealth y2 > y1. We define the relative risk...... premium as the quotient between the risk premium and the increase in wealth y1–x which the decision maker puts on the line by choosing the lottery in place of receiving y1 with certainty. We study preferences such that the relative risk premium is a decreasing function of present wealth, and we determine...

  6. Decreasing Serial Cost Sharing

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Østerdal, Lars Peter

    The increasing serial cost sharing rule of Moulin and Shenker [Econometrica 60 (1992) 1009] and the decreasing serial rule of de Frutos [Journal of Economic Theory 79 (1998) 245] have attracted attention due to their intuitive appeal and striking incentive properties. An axiomatic characterization...... of the increasing serial rule was provided by Moulin and Shenker [Journal of Economic Theory 64 (1994) 178]. This paper gives an axiomatic characterization of the decreasing serial rule...

  7. Decreasing serial cost sharing

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Østerdal, Lars Peter Raahave

    2009-01-01

    The increasing serial cost sharing rule of Moulin and Shenker (Econometrica 60:1009-1037, 1992) and the decreasing serial rule of de Frutos (J Econ Theory 79:245-275, 1998) are known by their intuitive appeal and striking incentive properties. An axiomatic characterization of the increasing serial...... rule was provided by Moulin and Shenker (J Econ Theory 64:178-201, 1994). This paper gives an axiomatic characterization of the decreasing serial rule....

  8. Lung density

    DEFF Research Database (Denmark)

    Garnett, E S; Webber, C E; Coates, G

    1977-01-01

    The density of a defined volume of the human lung can be measured in vivo by a new noninvasive technique. A beam of gamma-rays is directed at the lung and, by measuring the scattered gamma-rays, lung density is calculated. The density in the lower lobe of the right lung in normal man during quiet...... breathing in the sitting position ranged from 0.25 to 0.37 g.cm-3. Subnormal values were found in patients with emphsema. In patients with pulmonary congestion and edema, lung density values ranged from 0.33 to 0.93 g.cm-3. The lung density measurement correlated well with the findings in chest radiographs...... but the lung density values were more sensitive indices. This was particularly evident in serial observations of individual patients....

  9. Subúrbios e veredas - apontamentos para uma leitura comparada dos narradores em Dom Casmurro e Grande sertão: veredas

    Directory of Open Access Journals (Sweden)

    Wilson Madeira Filho

    2000-03-01

    Full Text Available Dois grandes autores, verdadeira unanimidade da crítica literária nacional, Machado de Assis e Guimarães Rosa representam a elaboração de uma escrita repleta de sutilezas, cuja metalinguagem permite desdobramentos na própria interação entre as esferas do autor e a do leitor. A questão da autoria, apresentada com picardia na abertura do Dom Casmurro, refrata-se em jogos interpretativos. No capítulo inicial, o narrador sugere uma bifurcação: de um lado, a biografia possível, de outro lado, a crônica histórico-social com a redação de uma Históriados subúrbios. No fundo, trata-se de um mesmo projeto, posto que ambos, o cidadão e a cidade, projetam-se em suas face tas ocultas; no centro urbano, as vias de acesso via trem da Central do Brasil, articulandoas a rtérias da polis; no homem, os recônditos da alma, a irromper no fluxo de uma memória que se quer centralizadora. Por sua vez, herdandoa perplexidade e tentativa de "atar as pontas da vida", a ascese de Riobaldo confunde-se com a de um grande sertão cujas trilhas compõema trajetória hermética de desvendamento dos contrários, da revelação do Tudo no Nada. A obra de Machado é permeada pelo pessimismode Schopenhauer, narrando-se o desespero de uma vida onde tudo tornou-se vão. A de Rosa, enlaça a admiração inicial de Nietzsche por Schopenhauer para, contudo, reverter esse pessimismo através da teoria do eterno retorno e dos aforismos de Zarathustra, com a alternânciada alegria e do desespero, da criação e da destru ição, do bem e do mal.

  10. Conhecimento e uso da carnaúba e da algaroba em comunidades do Sertão do Rio Grande do Norte, Nordeste do Brasil

    Directory of Open Access Journals (Sweden)

    Laís Costa Rodrigues

    2013-06-01

    Full Text Available Em comunidades rurais do Vale do Açu, sertão do Rio Grande do Norte, investigaram-se o conhecimento e uso de Copernicia prunifera (carnaúba, palmeira nativa do Nordeste do Brasil; e de Prosopis juliflora (algaroba, leguminosa originária do Peru, intencionalmente introduzida na mesma região na década de 1940. Foram entrevistados 74 moradores de quatro comunidades estabelecidas no Município de Carnaubais, que citaram o uso de 142 espécies vegetais, nativas e introduzidas. Os dados foram analisados considerando-se a faixa etária dos entrevistados e as categorias de uso das plantas por eles citadas. Avaliou-se o índice de significado cultural de cada espécie que apontou seu valor para a sobrevivência biológica e cultural dos membros da comunidade. Os usos da carnaúba citados por 59% dos informantes se enquadravam nas categorias artesanato, combustível e medicinal. A categoria que mais contribuía para o uso da carnaúba era a categoria construção (UDs Coper 0,72. A algaroba tem uso como combustível e forragem, citados por 61% dos entrevistados. Calculou-se o valor da diversidade de uso mostrando que a categoria combustível (UDs Pros 0,37 era a que mais contribuía para o uso da algaroba nas comunidades rurais. Apesar do desequilíbrio ambiental ocasionado por sua introdução, a algaroba ajuda na subsistência das comunidades estudadas e aumentou o repertório de espécies fornecedoras de madeira para lenha, carvão e construção. A carnaúba, antes bastante utilizada pela população, vem sendo substituída por outras espécies, sendo estas atualmente as novas fontes de renda para a população local.

  11. Análise sensorial da água de coco anão verde processada e comercializada no sertão paraibano e cearense

    Directory of Open Access Journals (Sweden)

    Suziane Alves Josino Lima

    2015-06-01

    Full Text Available O Brasil, atualmente, possui uma grande tendência de crescimento do cultivo do coqueiro anão verde, onde o principal objetivo deste se da para a produção da água de coco, sua cultura esta distribuída em todo o território nacional, destacadamente na região Nordeste onde se concentram os maiores plantios do país. A água de coco é um produto natural que vem ganhando espaço no mercado como uma bebida de vasto potencial comercial, pois além de ser um produto natural é praticamente livre de contaminações, possui baixo teor calórico, considerável valor nutricional e apresenta aroma e sabor suaves e agradáveis. Neste contexto se faz necessário a avaliação da qualidade sensorial da água de coco industrializada e comercializada de forma a garantir a qualidade do produto para o consumidor. Com isso este trabalho objetivou avaliar sensorialmente á água de coco anão verde, produzidas comercialmente e envasadas, por indústrias do Sertão Paraibano e do Ceará. As amostras de água de coco proveniente das indústrias, foram analisadas sensorialmente no laboratório de microbiologia do CVT – UFCG - Pombal, utilizando o teste de comparação múltiplas utilizando uma escala hedônica de 9 pontos (9 = gostei extremamente, até 1 desgostei, também foi aplicado o teste de intenção de compra utilizando-se uma escala estruturada de 5 pontos (1 = certamente compraria, até 5 = Certamente compraria, conforme metodologia do Instituto Adolfo Lutz. Os resultados dos testes somente se deram até o 15 dias de armazenamento, onde 70% dos copos de água de coco armazenados, apresentaram-se turvos e com produção de gás, demonstrando apartir deste ponto impróprios para o consumo. Com 30 dias de armazenamento todas as amostras apresentaram insatisfatórios para consumo, demonstrando resultados preocupantes quanto a estabilidade da qualidade do produto durante sua validade comercial. Sugere-se como forma de garantia e manutenção da qualidade

  12. Decreasing relative risk premium

    DEFF Research Database (Denmark)

    Hansen, Frank

    2007-01-01

    such that the corresponding relative risk premium is a decreasing function of present wealth, and we determine the set of associated utility functions. We find a new characterization of risk vulnerability and determine a large set of utility functions, closed under summation and composition, which are both risk vulnerable...

  13. Decreasing asthma morbidity

    African Journals Online (AJOL)

    1994-12-12

    Dec 12, 1994 ... Apart from the optimal use of drugs, various supplementary methods have been tested to decrease asthma morbidity, usually in patients from reiatively affluent socio-economic backgrounds. A study of additional measures taken in a group of moderate to severe adult asthmatics from very poor socio- ...

  14. Photography as anthropological record of leader females in inland central CearáA fotografia como registro antropológico das mulheres líderes no Sertão Central do Ceará

    Directory of Open Access Journals (Sweden)

    Cristiana Parente

    2007-01-01

    Full Text Available In the last few years, in the inland of Ceará state, changes have occurred in gender relations. Women who find themselves leaders are producing modifications in the history of their communities and contributing to the development of a new culture. Recording the lives of these women through photography as anthropological resource is the objective of this work. It covers the experiences of leader women in the landless settlements of PDHC – Projeto Dom Helder Câmara in the city of Quixeramobim, in central inland Ceará.Nos últimos anos, no sertão do estado do Ceará, tem ocorrido mudanças nas relações de gênero. Mulheres que se descobrem líderes têm transformado a história de suas comunidades e contribuído para o despertar de uma nova cultura. Documentar a realidade destas mulheres, usando a fotografia como registro antropológico, é o objetivo deste trabalho. Ele documenta experiências de mulheres líderes nos assentamentos do PDHC – Projeto Dom Hélder Câmara na cidade de Quixeramobim, no Sertão Central do Ceará.

  15. The equipment supply industry to sugar mills, ethanol and energy in Brazil: an analysis based in leading companies and key-organizations of sector and of LPA of Sertãozinho

    Directory of Open Access Journals (Sweden)

    Michelle Castro Carrijo

    2015-12-01

    Full Text Available This study aims to analyze the profile, organization, efficiency and innovation in the supply industry equipment for sugar mills, ethanol and energy in Brazil, contributing to an important discussion on the competitiveness of this industry. Therefore, the study was based on analysis of information obtained from two surveys: the first held with representative organizations and two industry-leading companies located in the cities of Sertãozinho and Piracicaba; and the second, through interviews with companies in the Local Productive Arrangement (LPA of Sertãozinho, known as the Silicon Valley Ethanol. The results suggest that the increasing modernization of the sector will require greater efforts from equipment industry to provide plants with the necessary technological innovations and potential efficiency gains and that the constituent companies of this industry, few invest in technology and professional training, in other words, are lacking in management training, which leads to loss of valuable opportunities, international market share is tiny, most companies turn to private sources of financing, and companies seem unaware of the real benefits of cooperation, although they appear in most companies in this industry.

  16. Low Bone Density

    Science.gov (United States)

    ... Density Exam/Testing › Low Bone Density Low Bone Density Low bone density is when your bone density ... people with normal bone density. Detecting Low Bone Density A bone density test will determine whether you ...

  17. Água de Coco comercializadas no Sertão do Ceará e Paraíba: Imprópria ao consumo

    Directory of Open Access Journals (Sweden)

    Suziane Alves Josino Lima

    2014-10-01

    Full Text Available A água de coco é considerada um isotônico natural, rica em nutrientes e altamente atrativa devido a seu valor nutricional e sabor, com a busca por alimentos saudáveis nos tempos atuais seu consumo tem aumentado consideravelmente principalmente na forma industrializada no Nordeste do Brasil onde se concentram os maiores plantios do coqueiro anão verde, tornando assim indispensável a avaliação da qualidade da água de coco comercializada nesta região. Neste sentido, este trabalho objetivou avaliar a qualidade microbiológica de amostras de água de coco, industrializada e comercializada por duas empresas no sertão paraibano e cearense. Como parâmetros da qualidade microbiológica foram realizadas as seguintes análises: Coliformes Termotolerantes,Salmonella spp/25g, Bolores e Leveduras e contagem de Microrganismos Aeróbios Psicrotróficos nas amostras. A água de coco anão verde comercializada pela indústria A, apresentou resultados de coliformes totais variando de 7 NMP/mL a 1,5 x 102 NMP/mL e < 3 NMP/mL a 7 NMP/mL para coliformes termotolerantes, estes valores oscilaram durante os trintas dias de armazenamento tempo este de validade do produto industrializado. Também foram detectados nas amostras analisadas uma alta contagem de bactérias, nas amostras da água de coco da indústria A armazenada sob-refrigeração, indicando assim possivelmente o uso de matéria prima contaminada, falhas no processamento distribuição e ou armazenamento, estas diretamente relacionadas ao binômio tempo/temperatura insatisfatórios. Os valores encontrados para Bolores e Leveduras variaram de 5,05x102 UFC/mL a 7,6x105 UFC/mL, valores estes considerados elevados, caracterizando a água de coco como imprópria para o consumo quando comparadas á legislação vigente. De acordo com os resultados sugere-se que esta contaminação tenha ocorrido durante a manipulação e ou processamento, uma vez que esta apresenta-se estéril dentro do seu próprio inv

  18. Level densities

    International Nuclear Information System (INIS)

    Ignatyuk, A.V.

    1998-01-01

    For any applications of the statistical theory of nuclear reactions it is very important to obtain the parameters of the level density description from the reliable experimental data. The cumulative numbers of low-lying levels and the average spacings between neutron resonances are usually used as such data. The level density parameters fitted to such data are compiled in the RIPL Starter File for the tree models most frequently used in practical calculations: i) For the Gilber-Cameron model the parameters of the Beijing group, based on a rather recent compilations of the neutron resonance and low-lying level densities and included into the beijing-gc.dat file, are chosen as recommended. As alternative versions the parameters provided by other groups are given into the files: jaeri-gc.dat, bombay-gc.dat, obninsk-gc.dat. Additionally the iljinov-gc.dat, and mengoni-gc.dat files include sets of the level density parameters that take into account the damping of shell effects at high energies. ii) For the backed-shifted Fermi gas model the beijing-bs.dat file is selected as the recommended one. Alternative parameters of the Obninsk group are given in the obninsk-bs.dat file and those of Bombay in bombay-bs.dat. iii) For the generalized superfluid model the Obninsk group parameters included into the obninsk-bcs.dat file are chosen as recommended ones and the beijing-bcs.dat file is included as an alternative set of parameters. iv) For the microscopic approach to the level densities the files are: obninsk-micro.for -FORTRAN 77 source for the microscopical statistical level density code developed in Obninsk by Ignatyuk and coworkers, moller-levels.gz - Moeller single-particle level and ground state deformation data base, moller-levels.for -retrieval code for Moeller single-particle level scheme. (author)

  19. In vivo studies of the SERT-selective [{sup 18}F]FPBM and VMAT2-selective [{sup 18}F]AV-133 radiotracers in a rat model of Parkinson's disease

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Julie L. [Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 (United States); Oya, Shunichi; Parhi, Ajit K.; Lieberman, Brian P.; Ploessl, Karl; Hou, Catherine [Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 (United States); Kung, Hank F. [Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 (United States); Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 (United States)], E-mail: kunghf@sunmac.spect.upenn.edu

    2010-05-15

    Introduction: The utility of [{sup 18}F]FPBM [2-(2'-((dimethylamino)methyl)-4'-(3-[{sup 18}F] -fluoropropoxy)phenylthio)benzenamine], a selective serotonin transporter (SERT) tracer, and [{sup 18}F]AV-133 [(+)-2-Hydroxy-3-isobutyl-9-(3-fluoropropoxy)-10-methoxy-1,2,3,4,6, 7-hexahydro-11bH-benzo[a]quinolizine], a selective vesicular monoamine transporter 2 (VMAT2) tracer, were tested in the 6-hydroxydopamine (6-OHDA) unilateral lesioned rat model. Methods: Positron emission tomography (PET) imaging of three 6-OHDA unilateral lesioned male Sprague Dawley rats (Rats 1-3) were performed with [{sup 18}F]FPBM and [{sup 18}F]AV-133 to examine whether changes in SERT and VMAT2 binding, respectively, could be detected in the brain. The brains of the three rats were then removed and examined by in vitro autoradiography with [{sup 18}F]FPBM and the dopamine transporter ligand, [{sup 125}I]IPT [N-(3'-[{sup 125}I]-iodopropen-2'-yl)-2-beta-carbomethoxy-3-beta-(4-chloro phenyl) tropane, for confirmation. Biodistribution of [{sup 18}F]FPBM in a separate group of p-chloroamphetamine (PCA) treated rats were also performed. Results: PET image analysis showed varying levels of SERT binding reduction (Rat 1=-11%, Rat 2=-4%, Rat 3=-43%; n=2) and a clear and definitive loss of VMAT2 binding (Rat 1=-87%, Rat 2=-72%, and Rat 3=-91%; n=1) in the left striatum when compared to the right (non-lesioned side) striatum. The results from PET imaging were corroborated with quantitative in vitro autoradiography. Rats treated with a selective serotonin toxin (p-chloroamphetamine) showed a significant reduction of [{sup 18}F]FPBM uptake in the cortex and hypothalamus regions of the brain. Conclusion: The preliminary data suggest that [{sup 18}F]FPBM and [{sup 18}F]AV-133 may be useful for the examination of serotonergic and dopaminergic neuron integrity, respectively, in the living brain.

  20. Efeitos da seleção para peso pós-desmame sobre medidas corporais e perímetro escrotal de machos Nelore de Sertãozinho (SP Effects of post-weaning weight selection on body measurements and scrotal perimeter in Nellore males of Sertãozinho (SP

    Directory of Open Access Journals (Sweden)

    Joslaine Noely dos Santos Gonçalves Cyrillo

    2000-04-01

    Full Text Available O objetivo deste estudo foi avaliar o efeito indireto da seleção para peso pós-desmame sobre medidas corporais e perímetro escrotal de 809 machos Nelore, pertencentes às populações selecionadas (NeS e NeT e controle (NeC, da Estação Experimental de Zootecnia de Sertãozinho. As análises estatísticas foram executadas usando-se modelos de touros, sendo que a fonte de variação aleatória, touro, foi aninhada dentro de rebanho. Os efeitos fixos considerados foram: rebanho, ano de realização da Prova de Ganho de Peso (PGP, idade de vaca em anos e idade do animal em dias como covariável. A mudança genética, obtida como a diferença dos rebanhos selecionados em relação ao rebanho controle, foi 40,2 e 44,3 kg, para peso aos 378 dias (P378, para os rebanhos NeS e NeT, respectivamente. As mudanças para as demais características, na mesma ordem, foram 4,5 e 4,5 cm para altura na garupa (ATPF; 6,2 e 7,0 cm para perímetro torácico (PTOR; 5,8 e 6,3 cm para comprimento do corpo (COM; 2,9 e 2,0 cm para comprimento do dorso (DOR; 1,7 e 2,4 cm para comprimento da garupa, (GAR; 1,0 e 1,3 cm para distância de ísquios (ISQ; 1,8 e 2,6 cm para distância de íleos (ILEO; e 1,3 e 2,2 cm para perímetro escrotal (PE. Os resultados deste estudo mostraram que a seleção direta para peso pós-desmame promoveu respostas positivas correlacionadas nas dimensões de regiões do corpo de machos Nelore.The objective of this study was to evaluate the indirect effects of selection for post-weaning weight on body measures and scrotal perimeter of 809 Nellore males from selected herds (NeS and NeT and control herd (NeC, of the Estação Experimental de Zootecnia de Sertãozinho. The statistical analyses were performed by using a sire mixed model where the random source of variation, sires, was nested within herds. The fixed effects were herds, year of performance test (PGP, age of cow and age of the animal as a covariate. The average genetic change for

  1. Mineralogia, micromorfologia e gênese de solos planossólicos do Sertão do Araripe, estado de Pernambuco Mineralogy, micromorphology and genesis of soils with stagnic properties from Sertão of Araripe, Pernambuco State, Brazil

    Directory of Open Access Journals (Sweden)

    L. B. Oliveira

    2004-08-01

    Full Text Available Neste trabalho, objetivou-se realizar a caracterização mineralógica e micromorfológica de solos planossólicos do Sertão do Araripe, estado de Pernambuco, visando proporcionar melhor entendimento de suas propriedades e dos processos envolvidos em sua gênese. Tais solos foram, até então, pouco estudados e se caracterizam pela ocorrência de um horizonte B plânico subjacente a um horizonte B textural, plíntico ou não. No município de Ouricuri, foram selecionados três perfis representativos destes solos, classificados como: Plintossolo Argilúvico eutrófico planossólico sódico (perfil 1; Argissolo Amarelo eutrófico planossólico solódico (perfil 2 e Argissolo Amarelo eutrófico plíntico planossólico sódico (perfil 3. A mineralogia das frações calhau e cascalho foi determinada macroscopicamente, enquanto a da areia, por lupa binocular. As frações silte e argila foram analisadas por difratometria de raios X. As descrições micromorfológicas foram realizadas em seções delgadas de amostras de horizontes selecionados. A fração areia destes solos é essencialmente composta por quartzo, mas feldspatos e mica também ocorrem a partir do horizonte 2Btbn. O silte é basicamente constituído por quartzo, feldspatos e mica. A argila é composta por caulinita, mica, interestratificados irregulares, esmectita e quartzo, ocorrendo as maiores quantidades de esmectita e interestratificados nos horizontes 2Btbn e 2BCn. O horizonte B plânico (2Btbn apresenta microestrutura em blocos angulares e expressivos argilãs (de iluviação e intemperização, enquanto o horizonte Bt sobrejacente apresenta microestrutura granular e ausência de qualquer tipo de argilã. A disparidade observada na mineralogia da fração argila e as distintas feições micromorfológicas corroboram a identificação de uma mudança de material de origem entre os horizontes Bt e B plânico dos solos estudados. A posição do horizonte B plânico, que apresenta

  2. Estimativas de tendências e parâmetros genéticos do peso padronizado aos 378 dias de idade, medidas corporais e perímetro escrotal de machos Nelore de Sertãozinho, SP Estimates of genetic parameters and trends for body weight at 378 days, body measurements and scrotal circumference of Sertãozinho Nellore males

    Directory of Open Access Journals (Sweden)

    Joslaine Noely dos Santos Gonçalves Cyrillo

    2001-02-01

    Full Text Available Os objetivos deste estudo foram estimar as tendências e os parâmetros genéticos e fenotípicos do peso padronizado aos 378 dias de idade (P378, medidas corporais e perímetro escrotal de machos Nelore, pertencentes às populações selecionadas e controle da Estação Experimental de Zootecnia de Sertãozinho. As herdabilidades, estimadas considerando-se modelo de touro e modelo animal, foram, respectivamente, 0,53±0,12 e 0,36 para P378; 0,38±0,11 e 0,58 para altura na garupa; 0,31±0,10 e 0,10 para perímetro torácico; 0,40± 0,11 e 0,13 para comprimento do corpo; 0,39±0,11 e 0,30 para comprimento do dorso; 0,33±0,10 e 0,12 para comprimento da garupa; 0,08± 0,07 e 0,14 para distância de ísquios; 0,23±0,09 e 0,08 para distância de íleos e 0,57±0,13 e 0,44 para perímetro escrotal. A correlação genética mais alta entre P378 e medidas corporais foi encontrada para perímetro torácico (0,86 ± 0,08; as demais variaram de 0,46 a 0,72. Os resultados deste estudo mostraram que, em função dos valores médios a altos das herdabilidades estimadas para P378 e da maioria das características de medidas do corpo dos animais, houve considerável variação genética aditiva nesses atributos. Além disso, devido às altas correlações genéticas de P378 com a maioria das características, pode-se concluir ser bastante provável que grande parte dos genes que controlam o peso pós-desmame também seja responsável pelo desenvolvimento das diferentes regiões do corpo de machos Nelore. A magnitude desses parâmetros justifica a tendência genética positiva nas características de seleção direta e nas secundárias.The objectives of this study were to estimate the genetic trends and also the genetic and phenotypic parameters for body weight at 378 days (W378, body measurements and scrotal circumferences of Nellore males from selected and control populations of the Estação Experimental de Zootecnia de Sertãozinho (SP, Brazil. The

  3. Morbidade da doença de Chagas em áreas do Sertão da Paraíba e da Caatinga do Piauí

    Directory of Open Access Journals (Sweden)

    José Rodrigues Coura

    1996-04-01

    Full Text Available Foram estudados 186 pares de indivíduos sorologicamente positivos e negativos para infecção chagásica, da mesma idade e sexo, do Sertão da Paraíba e 200 indivíduos também sorologicamente positivos nos municípios de Oeiras e Colônia do Piauí. Depois de confirmados por pelo menos dois outros testes sorológicos: imunofluorescência indireta quantitativa, ELISA, hemaglutinação ou fixação do complemento,foi feito o exame clínico, eletrocardiográfico e radiológico nos indivíduos selecionados para o estudo exenodiagnóstico, hemocultura e PCR em amostras representativas dos casos soropositivos. As manifestações clínicas predominantes entre os soropositivos em ambas as áreas foram palpitações, dispnéia aos esforços, disfagia, odinofagia, pirose e obstipação. As freqüências das alterações eletrocardiográficas sugestivas da doença de Chagas foram, respectivamente, na Paraíba e no Piauí: BAV = 3,8 % e 2 %, BRD III = 6,4 % e 7 %, BRD III + HBAE = 10,7 % e 10,5 % e extra-sístoles ventriculares complexas = 2,7 % e 3,% . O xenodiagnóstico foi positivo em 13 % dos casos soropositivos da Paraíba e em 34 % dos casos do Piauí, enquanto que o PCR foi positivo, respectivamente, em 44,6 e 59,5 %. A hemocultura realizada apenas no Piauí foi positiva em 25,7 % dos casos estudados. Foram realizados inquéritos triatomínicos em 132 domicílios e peridomicílios no Sertão da Paraíba e em 159 na Caatinga do Piauí, sendo capturados 16 exemplares de T. brasiliensis não infectados no peridomicílio na Paraíba e 750 exemplares no Piauí, dos quais 625 foram examinados: 49 de T. pseudomaculata não infectados com T. cruzi (19 no intradomicílio e 30 no peridomicílio e 576 de T. brasiliensis (371 no intradomicílio e 205 no peridomicílio entre os quais 32 (5,5% estavam infectados com T. cruzi (31 no intradomicílio e um no peridomicílio.A clinical and electrocardiographic case control study was carried out with 186 pairs of

  4. Incidência de lesões nos jogadores de futebol masculino sub-21 durante os Jogos Regionais de Sertãozinho-SP de 2006 Injury incidence in sub-21 male soccer players during Regional Games of Sertãozinho-SP 2006

    Directory of Open Access Journals (Sweden)

    Luiz Fernando Approbato Selistre

    2009-10-01

    Full Text Available INTRODUÇÃO: O futebol, o esporte mais popular e praticado pelo mundo, é também uma das modalidades esportivas onde o atleta é submetido a diversos tipos e intensidades de esforços. Atualmente essa modalidade sofreu modificações, deixando de dar ênfase à técnica e passando a privilegiar os componentes físicos, aumentando assim a probabilidade da ocorrência de lesões. OBJETIVO: Realizar um levantamento epidemiológico das lesões no Futebol de Campo Sub-21 durante os 50°s Jogos Regionais de Sertãozinho de 2006. METODOLOGIA: Este é um trabalho do tipo epidemiológico descritivo e analítico, com desenho transversal. Realizou-se o acompanhamento de todas as partidas da modalidade, registrando as lesões ocorridas, seguido de um levantamento e caracterização das lesões. As mesmas foram classificadas de acordo com seu perfil e segmento anatômico, posteriormente divididas por posição dos atletas. RESULTADOS: Houve maior incidência das lesões nos membros inferiores, com 127 (74,7%; quanto ao perfil, as lesões musculares foram mais prevalentes, com 64 (37,6% lesões. Os atletas do meio-campo foram os mais acometidos, com 72 (42,4% lesões. Dentro da classe de goleiros e defensores a maior prevalência de contusões foi de sete (63,6% e 11 (50%, respectivamente. Já os atacantes, laterais e meio-campistas apresentaram como predomínio as lesões musculares, sendo os primeiros com 11 (36,7%, seguidos de 12 (34,3% dos laterais e 33 (45,8% dos meio-campistas. CONCLUSÃO: Constatou-se que ocorreu maior índice de lesões em membros inferiores, sendo estas caracterizadas como as musculares de maior prevalência. Demonstrou-se ainda que as lesões apresentadas estão diretamente relacionadas com as características de cada posição.Soccer is one of the most popular and practiced sports in the world. It is a sport in which athletes are submitted to many types and effort intensities. This sport has changed over the years, and instead of

  5. Morbidade da doença de Chagas em áreas do Sertão da Paraíba e da Caatinga do Piauí

    Directory of Open Access Journals (Sweden)

    José Rodrigues Coura

    1996-04-01

    Full Text Available Foram estudados 186 pares de indivíduos sorologicamente positivos e negativos para infecção chagásica, da mesma idade e sexo, do Sertão da Paraíba e 200 indivíduos também sorologicamente positivos nos municípios de Oeiras e Colônia do Piauí. Depois de confirmados por pelo menos dois outros testes sorológicos: imunofluorescência indireta quantitativa, ELISA, hemaglutinação ou fixação do complemento,foi feito o exame clínico, eletrocardiográfico e radiológico nos indivíduos selecionados para o estudo exenodiagnóstico, hemocultura e PCR em amostras representativas dos casos soropositivos. As manifestações clínicas predominantes entre os soropositivos em ambas as áreas foram palpitações, dispnéia aos esforços, disfagia, odinofagia, pirose e obstipação. As freqüências das alterações eletrocardiográficas sugestivas da doença de Chagas foram, respectivamente, na Paraíba e no Piauí: BAV = 3,8 % e 2 %, BRD III = 6,4 % e 7 %, BRD III + HBAE = 10,7 % e 10,5 % e extra-sístoles ventriculares complexas = 2,7 % e 3,% . O xenodiagnóstico foi positivo em 13 % dos casos soropositivos da Paraíba e em 34 % dos casos do Piauí, enquanto que o PCR foi positivo, respectivamente, em 44,6 e 59,5 %. A hemocultura realizada apenas no Piauí foi positiva em 25,7 % dos casos estudados. Foram realizados inquéritos triatomínicos em 132 domicílios e peridomicílios no Sertão da Paraíba e em 159 na Caatinga do Piauí, sendo capturados 16 exemplares de T. brasiliensis não infectados no peridomicílio na Paraíba e 750 exemplares no Piauí, dos quais 625 foram examinados: 49 de T. pseudomaculata não infectados com T. cruzi (19 no intradomicílio e 30 no peridomicílio e 576 de T. brasiliensis (371 no intradomicílio e 205 no peridomicílio entre os quais 32 (5,5% estavam infectados com T. cruzi (31 no intradomicílio e um no peridomicílio.

  6. Discrete density of states

    International Nuclear Information System (INIS)

    Aydin, Alhun; Sisman, Altug

    2016-01-01

    By considering the quantum-mechanically minimum allowable energy interval, we exactly count number of states (NOS) and introduce discrete density of states (DOS) concept for a particle in a box for various dimensions. Expressions for bounded and unbounded continua are analytically recovered from discrete ones. Even though substantial fluctuations prevail in discrete DOS, they're almost completely flattened out after summation or integration operation. It's seen that relative errors of analytical expressions of bounded/unbounded continua rapidly decrease for high NOS values (weak confinement or high energy conditions), while the proposed analytical expressions based on Weyl's conjecture always preserve their lower error characteristic. - Highlights: • Discrete density of states considering minimum energy difference is proposed. • Analytical DOS and NOS formulas based on Weyl conjecture are given. • Discrete DOS and NOS functions are examined for various dimensions. • Relative errors of analytical formulas are much better than the conventional ones.

  7. Discrete density of states

    Energy Technology Data Exchange (ETDEWEB)

    Aydin, Alhun; Sisman, Altug, E-mail: sismanal@itu.edu.tr

    2016-03-22

    By considering the quantum-mechanically minimum allowable energy interval, we exactly count number of states (NOS) and introduce discrete density of states (DOS) concept for a particle in a box for various dimensions. Expressions for bounded and unbounded continua are analytically recovered from discrete ones. Even though substantial fluctuations prevail in discrete DOS, they're almost completely flattened out after summation or integration operation. It's seen that relative errors of analytical expressions of bounded/unbounded continua rapidly decrease for high NOS values (weak confinement or high energy conditions), while the proposed analytical expressions based on Weyl's conjecture always preserve their lower error characteristic. - Highlights: • Discrete density of states considering minimum energy difference is proposed. • Analytical DOS and NOS formulas based on Weyl conjecture are given. • Discrete DOS and NOS functions are examined for various dimensions. • Relative errors of analytical formulas are much better than the conventional ones.

  8. Quando morre a flor do sertão: figuração da morte em “Buriti” de João Guimarães Rosa

    Directory of Open Access Journals (Sweden)

    Sarah Maria Forte Diogo

    2008-12-01

    Full Text Available Este artigo tem por objetivo estudar de que modo é figurada a morte da personagem Maria Behú, de “Buriti”, Noites do sertão (1956, de João Guimarães Rosa e os símbolos que a ela se agregam. Para tanto, investigamos as focalizações narrativas que incidem sobre Behú, construindo sua imagem como beata, assexuada, atuante na esfera da metafísica, sendo a sua morte o início da intensa vivência da sexualidade pelos demais personagens. “Buriti” narra a estória dos habitantes da fazenda Buriti Bom e daqueles que por lá transitam e as mudanças que ocasionam na vida uns dos outros. Behú é a personagem que mais contrasta com o ambiente, pois dele difere por não apresentar marcas de erotismo ou vida plena. Behú funciona na novela como guardiã da tradição e da cultura, seus usos e seus costumes, estilizados pela linguagem roseana.Palavras-chave: João Guimarães Rosa; Cultura; Linguagem; Morte; Tradição.

  9. Airplane radiation dose decrease during a strong Forbush decrease

    Czech Academy of Sciences Publication Activity Database

    Spurný, František; Kudela, K.; Dachev, T.

    2004-01-01

    Roč. 2, S05001 (2004), s. 1-4 ISSN 1542-7390 Grant - others:EC project(XE) FIGM-CT2000-00068 Institutional research plan: CEZ:AV0Z1048901 Keywords : airplane dose * Forbush decrease * cosmic rays Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders

  10. Novidades (Novelty na Agricultura Familiar e sua associação com a agroecologia na produção de hortifrutigranjeiros no Território Sertão do Apodi (RN

    Directory of Open Access Journals (Sweden)

    Emanoel Márcio Nunes

    2018-01-01

    Full Text Available O objetivo do artigo é destacar práticas e manejos na produção de hortifrutigranjeiros do território Sertão do Apodi em experiências que associam a agricultura familiar com a agroecologia. E uma das iniciativas é trazer a abordagem das novidades e das inovações como contraponto aos modelos exógenos da agricultura moderna, sendo alternativa para o desenvolvimento rural e regional ancorado na agricultura familiar. Como procedimentos metodológicos, foram aplicados questionários com agricultores familiares que associam a sua produção agroecológica com a venda direta dos seus produtos, objetivando informações sobre a produção agroecológica e segurança alimentar. Diante disso, a pesquisa revelou a necessidade da agricultura familiar se adequar às exigências da legislação para a inserção em mercados, em que as novidades e a inovação na produção agroecológica devem acontecer no sentido de respeitar o ambiente e possibilitar a segurança alimentar e nutricional construindo a relação de confiança entre agricultores e consumidores. Por fim, apesar das limitações, os agricultores familiares têm potencial significativo para o desenvolvimento regional, com a conversão da agricultura moderna e produtivista para sistemas agroecológicos.

  11. Neuroprotective Properties of a Standardized Extract from Myracrodruon urundeuva Fr. All. (Aroeira-Do-Sertão, as Evaluated by a Parkinson’s Disease Model in Rats

    Directory of Open Access Journals (Sweden)

    Iana Calou

    2014-01-01

    Full Text Available Myracrodruon urundeuva Fr. All. (Anacardiaceae is a Brazilian medicinal species, which is common to the Northeastern Brazilian semiarid region, whose stem-bark is widely used in folk medicine. It is an endangered species, presenting as main bioactive components tannins and chalcones. In this work, we studied the neuroprotective effects of a standardized extract from cultivated M. urundeuva (SEMU, in a model of Parkinson’s disease. Thus, a unilateral injection of 6-OHDA was done into the rat right stratum. The animals were submitted to stereotaxic surgery, then treated with SEMU (5, 10, 20, or 40 mg/kg, p.o. for 2 weeks, subjected to behavioral tests, and euthanized for striata dissections and neurochemical, histological, and immunohistochemical analyses. We showed, for the first time, that SEMU reverted behavioral alterations seen in the 6-OHDA-lesioned group and partially blocked the decrease in DA and DOPAC contents. The numbers of viable neurons and TH immunopositive cells were increased by SEMU. In addition, the SEMU-treated 6-OHDA groups showed lower numbers of GFAP and OX-42 immunopositive cells. The neuroprotective action of SEMU is possibly related to the antioxidant and anti-inflammatory properties of M. urundeuva, pointing out to its potential use in the prevention or treatment of neurodegenerative conditions, such as Parkinson’s disease.

  12. In Vivo Investigation of Escitalopram’s Allosteric Site on the Serotonin Transporter

    Science.gov (United States)

    Murray, Karen E.; Ressler, Kerry J.; Owens, Michael J.

    2015-01-01

    Escitalopram is a commonly prescribed antidepressant of the selective serotonin reuptake inhibitor class. Clinical evidence and mapping of the serotonin transporter (SERT) identified that escitalopram, in addition to its binding to a primary uptake-blocking site, is capable of binding to the SERT via an allosteric site that is hypothesized to alter escitalopram’s kinetics at the SERT. The studies reported here examined the in vivo role of the SERT allosteric site in escitalopram action. A knockin mouse model that possesses an allosteric-null SERT was developed. Autoradiographic studies indicated that the knockin protein was expressed at a lower density than endogenous mouse SERT (approximately 10–30% of endogenous mouse SERT), but the knockin mice are a viable tool to study the allosteric site. Microdialysis studies in the ventral hippocampus found no measurable decrease in extracellular serotonin response after local escitalopram challenge in mice without the allosteric site compared to mice with the site (p = 0.297). In marble burying assays there was a modest effect of the absence of the allosteric site, with a larger systemic dose of escitalopram (10-fold) necessary for the same effect as in mice with intact SERT (p = 0.023). However, there was no effect of the allosteric site in the tail suspension test. Together these data suggest that there may be a regional specificity in the role of the allosteric site. The lack of a robust effect overall suggests that the role of the allosteric site for escitalopram on the SERT may not produce meaningful in vivo effects. PMID:26621784

  13. [Why is bread consumption decreasing?].

    Science.gov (United States)

    Rolland, M F; Chabert, C; Serville, Y

    1977-01-01

    In France bread plays a very special and ambivalent role among our foodstuffs because of the considerable drop in its consumption, its alleged harmful effects on our health and the respect in which it is traditionally held. More than half the 1 089 adults interviewed in this study say they have decreased their consumption of bread in the last 10 years. The reasons given vary according to age, body weight and urbanization level. The main reasons given for this restriction are the desire to prevent or reduce obesity, the decrease in physical activity, the general reduction in food consumption and the possibility of diversifying foods even further. Moreover, the decreasing appeal of bread in relation to other foods, as well as a modification in the structure of meals, in which bread becomes less useful to accompany other food, accentuate this loss of attraction. However, the respect for bread as part of the staple diet remains very acute as 95 p. 100 of those interviewed express a reluctance to throw bread away, more for cultural than economic reasons. Mechanization and urbanization having brought about a decrease in energy needs, the most common alimentary adaptation is general caloric restriction by which glucids, and especially bread, are curtailed.

  14. Análise tensional e morfológica da anastomose colônica na colite induzida por ácido acético a 10%, em ratos Wistar, tratados com extrato aquoso de aroeira-do-sertão a 10% (Myracrodruon urundeuva fr. all. Tensional and morphologic analysis of the colonic anastomosis on 10% acetic acid induced colitis, in Wistar rats, treated with 10% aroeira-do-sertão (Myracrodruon urundeuva fr. all. aqueous extract

    Directory of Open Access Journals (Sweden)

    Antonio Rubens Soares Martins Cavalcante

    2005-04-01

    Full Text Available OBJETIVO: Verificar, do ponto de vista tensional e morfológico, o efeito do extrato aquoso de aroeira-do-sertão a 10% na anastomose colônica, na vigência de colite induzida por ácido acético a 10%, em ratos Wistar. MÉTODOS: Foram utilizados 48 ratos da linhagem Wistar, distribuídos em dois grupos. Todos os animais foram submetidos à indução da colite por solução aquosa de ácido acético a 10%. Vinte e quatro horas após, os animais foram submetidos à laparotomia, colotomia transversa total e anastomose término-terminal com fio de polipropileno 5-0. Grupo A (veículo, animais tratados com veículo à base de carboximetilcelulose. Grupo B (aroeira, animais tratados com extrato aquoso de aroeira a 10%. Ambos tratamentos foram sob a forma de enema. Os grupos A e B foram distribuídos em subgrupos A3, A7, A14 e A21; B3, B7, B14 e B21, respectivamente, conforme a data prevista para a eutanásia (3, 7, 14 e 21 dias. Nas respectivas datas, os animais foram relaparotomizados, o segmento colônico contendo a anastomose foi ressecado, submetido ao teste de pressão e em seguida à análise histológica. Para o estudo morfológico, as lâminas foram coradas com hematoxilina-eosina e avaliou-se a condição de cicatrização baseado numa tabela de escores que variava de 0 a 16. Quanto maior o escore melhor o grau de cicatrização. RESULTADOS: Na avaliação do estudo morfológico, que quantifica a evolução e o grau de cicatrização, como resultado final do processo cicatricial, o grupo aroeira foi superior ao grupo veículo (pPURPOSE: Verify, from a morphologic and tensional view point, the effect of the 10% aqueous extract of aroeira-do-sertão on the colonic anastomosis, during the occurrence of 10% acetic acid induced colitis, in Wistar rats. METHODS: There were used 48 Wistar rats, distributed in two groups. All animals were subjected to induction of colitis by aqueous solution of 10% acetic acid. Twenty-four hours later, the animals

  15. Magical thinking decreases across adulthood.

    Science.gov (United States)

    Brashier, Nadia M; Multhaup, Kristi S

    2017-12-01

    Magical thinking, or illogical causal reasoning such as superstitions, decreases across childhood, but almost no data speak to whether this developmental trajectory continues across the life span. In four experiments, magical thinking decreased across adulthood. This pattern replicated across two judgment domains and could not be explained by age-related differences in tolerance of ambiguity, domain-specific knowledge, or search for meaning. These data complement and extend findings that experience, accumulated over decades, guides older adults' judgments so that they match, or even exceed, young adults' performance. They also counter participants' expectations, and cultural sayings (e.g., "old wives' tales"), that suggest that older adults are especially superstitious. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  16. Does fertility decrease household consumption?

    OpenAIRE

    Jungho Kim; Henriette Engelhardt; Alexia Fürnkranz-Prskawetz; Arnstein Aassve

    2009-01-01

    This paper presents an empirical analysis of the relationship between fertility and a direct measure of poverty for Indonesia, a country, which has experienced unprecedented economic growth and sharp fertility declines over recent decades. It focuses on illustrating the sensitivity of the effect of fertility on household consumption with respect to the equivalence scale by applying the propensity score matching method. The analysis suggests that a newborn child decreases household consumption...

  17. Valorisation du sable de concassage et du sable du désert dans la composition des bétons autoplaçants Valorization of the crushed sand and of the desert sand in the composition of the self compacting concrete

    Directory of Open Access Journals (Sweden)

    R’mili A.

    2012-09-01

    Full Text Available Les bétons autopla÷ants (BAP sont des bétons très fluides qui demandent des dosages élevés en sables et en éléments fins par rapport au béton ordinaire (BO. Le sable de concassage (SC, à granularité étalée, est un sous-produit de concassage des roches massives. Le sable du désert (SD est un sable extra-fin, caractérisé par une distribution serrée de grosseur des grains. Renfermant des teneurs importantes en fines, ces deux sables peuvent êtres des composants intéressants des BAP. Cette recherché consiste à incorporer le SC dans la composition des bétons et étudier l’effet de son remplacement progressif par le SD sur le comportement à l’état frais et durci des BAP. L’étude expérimentale montre que les paramètres d’ouvrabilité des BAP sont améliorés lorsque le SC est partiellement remplacé par le SD ( 30%, des quantités supplémentaires en eau et en superplastifiant sont nécessaires, pour répondre aux propriétés autopla÷antes. Les résistances mécaniques diminuent en ajoutant le SD au SC, mais elles atteignent des valeurs acceptables pour des dosages modérés en SD. Les performances des BAP sont nettement meilleures que celles des BO confectionnées avec les mêmes granulats. Les essais de spécification de la durabilité montrent que les coefficients d’absorption d’eau par capillarité et par immersion augmentent en ajoutant le SD au SC alors que le coefficient de perméabilité diminue. Self-compacting concretes (SCC are highly fluid concretes that require high proportions in sand and fine particles with respect to the ordinary concrete (OC. The crushed sand (CS, spread granulometry, is a by-product of crushing rock mass. The desert sand (DS is an extra fine sand, characterized by a tight distribution of grain size. Containing significant levels of fine sand, these two sands can be both interesting components of the SCC. This research is to incorporate the CS in the composition of concrete and

  18. Análise florística e estrutura fitossociológica de um fragmento de Floresta Ombrófila Mista no município de Sertão - RSFloristic analysis and phytosociological structure of a Mixed Ombrophylous Forest

    OpenAIRE

    Piroli, Edson Luis; Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP; Nascimento, André Rosalvo Terra; Universidade Federal de Uberlândia - UFU

    2009-01-01

    Neste trabalho foram estudadas a composição florística e estrutura fitossociológica de um fragmento de Floresta Ombrófila Mista no município de Sertão, RS, com área aproximada de 700 ha. A análise estrutural destaca Araucaria angustifolia (Bertol.) Kuntze, como espécie dominante, principalmente na periferia do fragmento apresentando um número relativamente menor de indivíduos no interior da floresta. Abstract This paper appraises the study of the floristic composition and phytosociological st...

  19. The presence of Helicobacter Pylori in postmenopausal women is not a factor to the decrease of bone mineral density A presença do Helicobacter pylori em mulheres na pós-menopausa não constitui fator de risco para a diminuição da densidade mineral óssea

    Directory of Open Access Journals (Sweden)

    Adriana M. Kakehasi

    2007-09-01

    Full Text Available BACKGROUND: Osteoporosis affects approximately 30% of postmenopausal women. Gastrectomy, pernicious anemia, and more recently Helicobacter pylori infection, have all been implicated in the pathogenesis of osteoporosis. A reduced parietal cell mass is a common feature in these conditions. AIM: To study a possible relationship between chronic gastritis, parietal cell density of the oxyntic mucosa and bone mineral density in postmenopausal women, as chronic gastritis, Helicobacter pylori infection and osteoporosis are frequently observed in the elderly. METHODS: Fifty postmenopausal women (61.7 ± 7 years were submitted to gastroduodenal endoscopy and bone densitometry by dual energy X-ray absorptiometry. Glandular atrophy was evaluated objectively by the determination of parietal cell density. Helicobacter pylori infection was evaluated by histology, urease test and breath test with 13C. RESULTS: Thirty-two patients (64% presented chronic multifocal gastritis, and 20 of them (40% showed signs of gastric mucosa atrophy. Lumbar spine osteoporosis was found in 18 patients (36%. The parietal cell density in patients with and without osteoporosis was 948 ± 188 and 804 ± 203 cells/mm², respectively. Ten osteoporotic patients (55% and 24 non-osteoporotic patients (75% were infected by Helicobacter pylori. CONCLUSION: Postmenopausal women with osteoporosis presented a well-preserved parietal cell density in comparison with their counterparts without osteoporosis. Helicobacter pylori infection was not different between the two groups. We concluded that neither atrophic chronic gastritis nor Helicobacter pylori seem to be a reliable risk factor to osteoporosis in postmenopausal women.RACIONAL: A osteoporose afeta aproximadamente 30% das mulheres na pós-menopausa. Gastrectomia, anemia perniciosa e mais recentemente, a infecção pelo H. pylori, têm sido implicados na patogênese da osteoporose. A diminuição da massa de células parietais constitui

  20. Laboratory Density Functionals

    OpenAIRE

    Giraud, B. G.

    2007-01-01

    We compare several definitions of the density of a self-bound system, such as a nucleus, in relation with its center-of-mass zero-point motion. A trivial deconvolution relates the internal density to the density defined in the laboratory frame. This result is useful for the practical definition of density functionals.

  1. Decreasing Fires in Mediterranean Europe.

    Directory of Open Access Journals (Sweden)

    Marco Turco

    Full Text Available Forest fires are a serious environmental hazard in southern Europe. Quantitative assessment of recent trends in fire statistics is important for assessing the possible shifts induced by climate and other environmental/socioeconomic changes in this area. Here we analyse recent fire trends in Portugal, Spain, southern France, Italy and Greece, building on a homogenized fire database integrating official fire statistics provided by several national/EU agencies. During the period 1985-2011, the total annual burned area (BA displayed a general decreasing trend, with the exception of Portugal, where a heterogeneous signal was found. Considering all countries globally, we found that BA decreased by about 3020 km2 over the 27-year-long study period (i.e. about -66% of the mean historical value. These results are consistent with those obtained on longer time scales when data were available, also yielding predominantly negative trends in Spain and France (1974-2011 and a mixed trend in Portugal (1980-2011. Similar overall results were found for the annual number of fires (NF, which globally decreased by about 12600 in the study period (about -59%, except for Spain where, excluding the provinces along the Mediterranean coast, an upward trend was found for the longer period. We argue that the negative trends can be explained, at least in part, by an increased effort in fire management and prevention after the big fires of the 1980's, while positive trends may be related to recent socioeconomic transformations leading to more hazardous landscape configurations, as well as to the observed warming of recent decades. We stress the importance of fire data homogenization prior to analysis, in order to alleviate spurious effects associated with non-stationarities in the data due to temporal variations in fire detection efforts.

  2. Decreasing Fires in Mediterranean Europe.

    Science.gov (United States)

    Turco, Marco; Bedia, Joaquín; Di Liberto, Fabrizio; Fiorucci, Paolo; von Hardenberg, Jost; Koutsias, Nikos; Llasat, Maria-Carmen; Xystrakis, Fotios; Provenzale, Antonello

    2016-01-01

    Forest fires are a serious environmental hazard in southern Europe. Quantitative assessment of recent trends in fire statistics is important for assessing the possible shifts induced by climate and other environmental/socioeconomic changes in this area. Here we analyse recent fire trends in Portugal, Spain, southern France, Italy and Greece, building on a homogenized fire database integrating official fire statistics provided by several national/EU agencies. During the period 1985-2011, the total annual burned area (BA) displayed a general decreasing trend, with the exception of Portugal, where a heterogeneous signal was found. Considering all countries globally, we found that BA decreased by about 3020 km2 over the 27-year-long study period (i.e. about -66% of the mean historical value). These results are consistent with those obtained on longer time scales when data were available, also yielding predominantly negative trends in Spain and France (1974-2011) and a mixed trend in Portugal (1980-2011). Similar overall results were found for the annual number of fires (NF), which globally decreased by about 12600 in the study period (about -59%), except for Spain where, excluding the provinces along the Mediterranean coast, an upward trend was found for the longer period. We argue that the negative trends can be explained, at least in part, by an increased effort in fire management and prevention after the big fires of the 1980's, while positive trends may be related to recent socioeconomic transformations leading to more hazardous landscape configurations, as well as to the observed warming of recent decades. We stress the importance of fire data homogenization prior to analysis, in order to alleviate spurious effects associated with non-stationarities in the data due to temporal variations in fire detection efforts.

  3. Technologies for Decreasing Mining Losses

    Science.gov (United States)

    Valgma, Ingo; Väizene, Vivika; Kolats, Margit; Saarnak, Martin

    2013-12-01

    In case of stratified deposits like oil shale deposit in Estonia, mining losses depend on mining technologies. Current research focuses on extraction and separation possibilities of mineral resources. Selective mining, selective crushing and separation tests have been performed, showing possibilities of decreasing mining losses. Rock crushing and screening process simulations were used for optimizing rock fractions. In addition mine backfilling, fine separation, and optimized drilling and blasting have been analyzed. All tested methods show potential and depend on mineral usage. Usage in addition depends on the utilization technology. The questions like stability of the material flow and influences of the quality fluctuations to the final yield are raised.

  4. Decreasing incidence rates of bacteremia

    DEFF Research Database (Denmark)

    Nielsen, Stig Lønberg; Pedersen, C; Jensen, T G

    2014-01-01

    BACKGROUND: Numerous studies have shown that the incidence rate of bacteremia has been increasing over time. However, few studies have distinguished between community-acquired, healthcare-associated and nosocomial bacteremia. METHODS: We conducted a population-based study among adults with first......-time bacteremia in Funen County, Denmark, during 2000-2008 (N = 7786). We reported mean and annual incidence rates (per 100,000 person-years), overall and by place of acquisition. Trends were estimated using a Poisson regression model. RESULTS: The overall incidence rate was 215.7, including 99.0 for community......-acquired, 50.0 for healthcare-associated and 66.7 for nosocomial bacteremia. During 2000-2008, the overall incidence rate decreased by 23.3% from 254.1 to 198.8 (3.3% annually, p incidence rate of community-acquired bacteremia decreased by 25.6% from 119.0 to 93.8 (3.7% annually, p

  5. Price of forest chips decreasing

    International Nuclear Information System (INIS)

    Hakkila, P.

    2001-01-01

    Use of forest chips was studied in 1999 in the national Puuenergia (Wood Energy) research program. Wood combusting heating plants were questioned about are the main reasons restricting the increment of the use of forest chips. Heating plants, which did not use forest chips at all or which used less than 250 m 3 (625 bulk- m 3 ) in 1999 were excluded. The main restrictions for additional use of forest chips were: too high price of forest chips; lack of suppliers and/or uncertainty of deliveries; technical problems of reception and processing of forest chips; insufficiency of boiler output especially in winter; and unsatisfactory quality of chips. The price of forest chips becomes relatively high because wood biomass used for production of forest chips has to be collected from wide area. Heavy equipment has to be used even though small fragments of wood are processed, which increases the price of chips. It is essential for forest chips that the costs can be pressed down because competition with fossil fuels, peat and industrial wood residues is hard. Low market price leads to the situation in which forest owner gets no price of the raw material, the entrepreneurs operate at the limit of profitability and renovation of machinery is difficult, and forest chips suppliers have to sell the chips at prime costs. Price of forest chips has decreased significantly during the past decade. Nominal price of forest chips is now lower than two decades ago. The real price of chips has decreased even more than the nominal price, 35% during the past decade and 20% during the last five years. Chips, made of small diameter wood, are expensive because the price includes the felling costs and harvesting is carried out at thinning lots. Price is especially high if chips are made of delimbed small diameter wood due to increased the work and reduced amount of chips. The price of logging residue chips is most profitable because cutting does not cause additional costs. Recovery of chips is

  6. Densities of carbon foils

    International Nuclear Information System (INIS)

    Stoner, J.O. Jr.

    1991-01-01

    The densities of arc-evaporated carbon target foils have been measured by several methods. The density depends upon the method used to measure it; for the same surface density, values obtained by different measurement techniques may differ by fifty percent or more. The most reliable density measurements are by flotation, yielding a density of 2.01±0.03 g cm -3 , and interferometric step height with the surface density known from auxiliary measurements, yielding a density of 2.61±0.4 g cm -3 . The difference between these density values mayy be due in part to the compressive stresses that carbon films have while still on their substrates, uncertainties in the optical calibration of surface densities of carbon foils, and systematic errors in step-height measurements. Mechanical thickness measurements by micrometer caliper are unreliable due to nonplanarity of these foils. (orig.)

  7. Rigidity spectrum of Forbush decrease

    International Nuclear Information System (INIS)

    Sakakibara, S.; Munakata, K.; Nagashima, K.

    1985-01-01

    Using data from neutron monitors and muon telescopes at surface and underground stations, the average rigidity spectrum of Forbush decreases (Fds) during the period of 1978-1982 were obtained. Thirty eight Ed-events are classified into two groups, Hard Fd and Soft FD according to size of Fd at the Sakashita station. It is found that a spectral form of a fractional-power type (P to the-gamma sub 1 (P+P sub c) to the -gamma sub2) is more suitable than that of a power-exponential type or of a power type with an upper limiting rigidity. The best fitted spectrum of the fractional-power type is expressed by gamma sub1 = 0.37, gamma sub2 = 0.89 and P subc = 10 GV for Hard Fd and gamma sub1 = 0.77, gamma sub2 = 1.02 and P sub c - 14GV for Soft Fd

  8. Method of decreasing nuclear power

    International Nuclear Information System (INIS)

    Masuda, Hiromi

    1987-01-01

    Purpose: To easily attain the power decreasing in a HWLWR type reactor and improve the reactor safety. Method: The method is applied to a nuclear reactor in which the reactor reactivity is controlled by control rods and liquid posions dissolved in moderators. Means for forecasting the control rod operation amount required for the reactor power down and means for removing liquid poisons in the moderators are provided. The control rod operation amount required for the power down is forecast before the power down and the liquid poisons in the moderators are removed. Then, the control rods are inserted into a deep insertion position to reduce the reactor power. This invention can facilitate easy power down, as well as provide effects of improving the controllability in the usual operation and of avoiding abrupt power down which leads to an improved availability. (Kamimura, M.)

  9. Sertão translated into Danish

    Directory of Open Access Journals (Sweden)

    Peter Poulsen

    2012-09-01

    Full Text Available This text is a transcription of a lecture given by Peter Poulsen, Danish writer and translator, during the event Discovering Brazilian Northeast with the Music by Luiz Gonzaga, which took place at Aarhus University on 26th and 27th of April, 2012. The aim of this event , promoted by the Brazilian Studies at Aarhus University, was to introduce Luiz Gonzaga and his music, showing how this singer-songwriter has shaped a vision of the people and landscape of northeast Brazil.

  10. Future Road Density

    Data.gov (United States)

    U.S. Environmental Protection Agency — Road density is generally highly correlated with amount of developed land cover. High road densities usually indicate high levels of ecological disturbance. More...

  11. Simulation of decreasing reactor power level with BWR simulator

    International Nuclear Information System (INIS)

    Suwoto; Zuhair; Rivai, Abu Khalid

    2002-01-01

    Study on characteristic of BWR using Desktop PC Based Simulator Program was analysed. This simulator is more efficient and cheaper for analyzing of characteristic and dynamic respond than full scope simulator for decreasing power level of BW. Dynamic responses of BWR reactor was investigated during the power level reduction from 100% FP (Full Power) which is 3926 MWth to 0% FP with 25% steps and 1 % FP/sec rate. The overall results for core flow rate, reactor steam flow, feed-water flow and turbine-generator power show tendency proportional to reduction of reactor power. This results show that reactor power control in BWR could be done by control of re-circulation flow that alter the density of water used as coolant and moderator. Decreasing the re-circulation flow rate will decrease void density which has negative reactivity and also affect the position of control rods

  12. Achieving maximum baryon densities

    International Nuclear Information System (INIS)

    Gyulassy, M.

    1984-01-01

    In continuing work on nuclear stopping power in the energy range E/sub lab/ approx. 10 GeV/nucleon, calculations were made of the energy and baryon densities that could be achieved in uranium-uranium collisions. Results are shown. The energy density reached could exceed 2 GeV/fm 3 and baryon densities could reach as high as ten times normal nuclear densities

  13. Crowding and Density

    Science.gov (United States)

    Design and Environment, 1972

    1972-01-01

    Three-part report pinpointing problems and uncovering solutions for the dual concepts of density (ratio of people to space) and crowding (psychological response to density). Section one, A Primer on Crowding,'' reviews new psychological and social findings; section two, Density in the Suburbs,'' shows conflict between status quo and increased…

  14. Device for measuring fission product density

    International Nuclear Information System (INIS)

    Kaneda, Mitsunori.

    1980-01-01

    Purpose: To determine the fission product density of xenon or the like and enable measurement of real time of fission product density in a reactor by calculating the disintegration and annihilation of the fission product on the basis of neutron detected output. Constitution: The neutron flux in a reactor is detected by a detector, and applied to first and second density calculators. Second fission product density signal of xenon or the like outputted from first device is again inputted to the device to form an annihilation signal due to disintegration to determine the present density of the second fission product of xenon or the like corresponding to the decrease of the neutron due to the poison of xeron or the like. Similarly, second device determines the first fission product density of iodine or the like. (Sekiya, K.)

  15. Estimativas da composição física das carcaças e do corpo vazio de amostras da 15ª progênie dos rebanhos Zebu e Caracu de Sertãozinho(SP Physical composition estimates of carcass and empty body weight on samples of the 15th progeny of Sertãozinho (SP-Brazil Zebu and Caracu herds

    Directory of Open Access Journals (Sweden)

    Alexander George Razook

    2001-06-01

    Full Text Available Foram estimadas as composições corporais físicas em termos de porcentagens de músculo, gordura e osso na meia carcaça esquerda e no peso vazio estimado (PVz, de 44 machos inteiros, nascidos em 1995 e terminados em confinamento, dos rebanhos selecionados para peso aos 378 dias (P378, da Estação Experimental de Zootecnia de Sertãozinho (SP. A amostra, representando a média de cada rebanho em P378, foi de 9 animais Gir (Gi; Nelore (NeS; Nelore Controle (NeC; Caracu (Ca e 8 Guzerá (GuS. O abate ocorreu aos 580 dias de idade e condição corporal 8 (escala 1-9. As estimativas foram obtidas por meio de equações estimadoras de quantidades (estimativa 1 de músculo, gordura e osso e porcentagens diretamente (estimativa 2 utilizando informações do corte entre a 9ª e 11ª costelas e outras características de abate. Os valores médios das duas estimativas para percentagens de músculo, gordura e osso na meia carcaça foram: Gi (65,9, 18,2 e 15,8; GuS (64,1, 21,3 e 14,6; NeC (63,0, 21,2 e 15,7; NeS (62,6, 21,3 e 16,0 e Ca (64,2, 17,1 e 18,6. Valores respectivos para % em PVz foram: Gi (41,5, 11,5 e 10,0; GuS (39,1, 13,0 e 8,9; NeC (40,0, 13,5 e 10,0 ; NeS (39,4, 13,4 e 10,1 e Ca (39,4, 10,5 e 11,4. A seleção para peso pós-desmame, visualizada na comparação entre os grupos Nelore, não promoveu alterações indiretas na composição corporal desses animais. As proporções de músculo nos outros grupos genéticos foram semelhantes aos Nelore. As porcentagens de gordura renal e pélvica, em relação ao PVz, também não foram diferentes entre animais dos vários rebanhos, contrariamente à proporção de gordura na carcaça e em PVz, que foi menor em animais Gi e Ca. As estimativas de composição corporal, resultantes dos dois tipos de equações, foram razoavelmente concordantes, diferindo somente para porcentagem de ossos em animais Ca.The body composition, in terms of percentages of muscle, fat and bone of carcass or empty body

  16. Probability densities and Lévy densities

    DEFF Research Database (Denmark)

    Barndorff-Nielsen, Ole Eiler

    For positive Lévy processes (i.e. subordinators) formulae are derived that express the probability density or the distribution function in terms of power series in time t. The applicability of the results to finance and to turbulence is briefly indicated.......For positive Lévy processes (i.e. subordinators) formulae are derived that express the probability density or the distribution function in terms of power series in time t. The applicability of the results to finance and to turbulence is briefly indicated....

  17. Desempenho em Pastagens e Características de Carcaça da 16a Progênie dos Rebanhos Nelore, Guzerá e Caracu de Sertãozinho (SP

    Directory of Open Access Journals (Sweden)

    Razook Alexander George

    2002-01-01

    Full Text Available Quarenta e um machos inteiros dos rebanhos selecionados para peso aos 378 dias (P378, nascidos em 1996, foram terminados em pastagens de Panicum Maximum (Jacq., Panicum Maximum (Jaq cv. Tanzania 1 e Brachiaria brizantha (Hoschst Stapf cv. Marandu na Estação Experimental de Zootecnia de Sertãozinho (SP. As amostras, representando a média de P378 em cada rebanho, foram: 11 animais Nelore Seleção (NeS e 10 para cada um dos grupos Nelore Controle (NeC, Guzerá Seleção (GuS e Caracu (Ca. O abate ocorreu aos 824 dias de idade e condição corporal 7,6, em uma escala de 1 a 9. As médias mínimas e máximas ajustadas, para as principais características, considerando-se todos os grupos, foram: ganho de peso médio diário, 406 (NeC e 501 g (NeS; peso de abate (PAB, 446,8 (NeC e 544,3 kg (NeS ; peso de carcaça (PCAR, 249,8 (NeC e 309,7 kg (NeS; rendimento de carcaça (REND, 54,0 (GuS e 56,3% (NeC e NeS. No corte entre a 9feminine e 11feminine costelas : músculo 59,6 (NeC e 65,2% (Ca; gordura, 15,6 (Ca e 21,4% (NeC; osso, 18,9 (NeC e 20,2% (GuS; espessura de gordura (ESPGOR, 2,0 (Ca e 4,2 mm (NeC; área de olho de lombo (AOL, 65,6 (NeC e 71,1 cmsuperscript two (NeS e Ca; força de cisalhamento (FC, 4,5 (Ca e 6,6 kg (GuS e perdas totais no cozimento (PERDAS, 22,5 (NeC e 24,9% (GuS. A seleção para peso provocou, em NeS, maiores PAB e PCAR, sem interferir no REND, na composição da costela, FC e PERDAS na carne. Houve, porém, menor ESPGOR em relação à NeC. Os animais GuS apresentaram PAB e PCAR intermediários, entre NeS e Ca, e menor REND e os Ca maior proporção de músculo na costela e carne com maior maciez em relação ao Zebu.

  18. Caracterização epidemiológica e fatores de risco associados às lentiviroses em pequenos ruminantes comercializados em feira de animais no Sertão de Pernambuco, semiárido brasileiro

    Directory of Open Access Journals (Sweden)

    José Romero Alexandre Alves

    2017-08-01

    Full Text Available Aglomerações de animais em eventos comerciais do tipo feiras de negócios representam um importante elo na transmissão de doenças infecciosas, resultando na importância do conhecimento acerca da epidemiologia das doenças de pequenos ruminantes. Desta forma, o objetivo desse estudo foi determinar a presença das lentiviroses em caprinos e ovinos comercializados na feira de animais da cidade de Tabira, Sertão de Pernambuco, bem como a identificação de possíveis fatores de risco associados à enfermidade. Foram coletadas amostras de soro de 233 caprinos e 119 ovinos, sem raça definida, pertencentes a doze proprietários, na feira de animais vivos do município no período de novembro de 2014 a junho de 2015. Foi aplicado questionário epidemiológico para análise dos fatores de risco. O diagnóstico da infecção por Lentivirus de Pequenos Ruminantes (LVPR nas espécies foi realizado pela Imunodifusão em ágar-gel (IDGA e Western Blotting (WB. Na IDGA foram utilizados antígenos de Vírus Maedi-visna (MVV para ovinos e de vírus da Artrite-Encefalite Caprina (CAEV, cepa CAEV- Cork para caprinos, e no WB foi utilizado a cepa CAEV- Cork como antígeno para ambas espécies. As variáveis obtidas no questionário foram submetidas a análises estatísticas univariada e multivariada. Pela técnica de IDGA foi possível identificar um caprino soropositivo. Não foi detectada positividade nos ovinos. No WB 15/233 (6,44%; IC95% = 3,94 - 10,35% caprinos e 8/119 (6,72%; IC95% = 3,45 - 12,71% ovinos foram soropositivos, totalizando 23/352 (6,53%; IC95% = 4,39 - 9,61% animais reagentes. Os doze rebanhos estudados apresentaram animais soropositivos. Vermifugar os animais anualmente (odds ratio = 5,9; IC 95% = 1,7 - 19,8; p = 0,04 foi identificado como fator de risco para enfermidade em caprinos. Não foram identificadas variáveis associadas ao risco de infecção em ovinos. Concluiu-se que os LVPR estão presentes em caprinos e ovinos

  19. Why Density Dependent Propulsion?

    Science.gov (United States)

    Robertson, Glen A.

    2011-01-01

    In 2004 Khoury and Weltman produced a density dependent cosmology theory they call the Chameleon, as at its nature, it is hidden within known physics. The Chameleon theory has implications to dark matter/energy with universe acceleration properties, which implies a new force mechanism with ties to the far and local density environment. In this paper, the Chameleon Density Model is discussed in terms of propulsion toward new propellant-less engineering methods.

  20. Density limits in Tokamaks

    International Nuclear Information System (INIS)

    Tendler, M.

    1984-06-01

    The energy loss from a tokamak plasma due to neutral hydrogen radiation and recycling is of great importance for the energy balance at the periphery. It is shown that the requirement for thermal equilibrium implies a constraint on the maximum attainable edge density. The relation to other density limits is discussed. The average plasma density is shown to be a strong function of the refuelling deposition profile. (author)

  1. Nuclear Level Densities

    International Nuclear Information System (INIS)

    Grimes, S.M.

    2005-01-01

    Recent research in the area of nuclear level densities is reviewed. The current interest in nuclear astrophysics and in structure of nuclei off of the line of stability has led to the development of radioactive beam facilities with larger machines currently being planned. Nuclear level densities for the systems used to produce the radioactive beams influence substantially the production rates of these beams. The modification of level-density parameters near the drip lines would also affect nucleosynthesis rates and abundances

  2. Growth limitation of Lemna minor due to high plant density

    NARCIS (Netherlands)

    Driever, S.M.; Nes, van E.H.; Roijackers, R.M.M.

    2005-01-01

    The effect of high population densities on the growth rate of Lemna minor (L.) was studied under laboratory conditions at 23°C in a medium with sufficient nutrients. At high population densities, we found a non-linear decreasing growth rate with increasing L. minor density. Above a L. minor biomass

  3. Density-dependent electron scattering in photoexcited GaAs

    DEFF Research Database (Denmark)

    Mics, Zoltán; D'’Angio, Andrea; Jensen, Søren A.

    2013-01-01

    —In a series of systematic optical pump - terahertz probe experiments we study the density-dependent electron scattering rate in photoexcited GaAs in a large range of carrier densities. The electron scattering time decreases by as much as a factor of 4, from 320 to 60 fs, as the electron density...

  4. Increased VLDL in nephrotic patients results from a decreased catabolism while increased LDL results from increased synthesis

    NARCIS (Netherlands)

    de Sain-van der Velden, M; Kaysen, GA; Barrett, HA; Stellaard, F; Gadellaa, MM; Voorbij, HA; Reijngoud, DJ; Rabelink, TJ

    Increased very low density lipoprotein (VLDL) in nephrotic patients results from a decreased catabolism while increased low density lipoprotein (LDL) results from increased synthesis. Hyperlipidemias a hallmark of nephrotic syndrome that has been associated with increased risk for ischemic heart

  5. Measurement of true density

    International Nuclear Information System (INIS)

    Carr-Brion, K.G.; Keen, E.F.

    1982-01-01

    System for determining the true density of a fluent mixture such as a liquid slurry, containing entrained gas, such as air comprises a restriction in pipe through which at least a part of the mixture is passed. Density measuring means such as gamma-ray detectors and source measure the apparent density of the mixture before and after its passage through the restriction. Solid-state pressure measuring devices are arranged to measure the pressure in the mixture before and after its passage through the restriction. Calculating means, such as a programmed microprocessor, determine the true density from these measurements using relationships given in the description. (author)

  6. Density of Liquid Ni-Cr Alloy

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The density of liquid Ni-Cr alloy was measured by a modified sessile drop method. The density of liquid Ni-Cr alloywas found to decrease with increasing temperature and Cr concentration in the alloy. The molar volume of liquidNi-Cr alloy increases with increasing the Cr concentration in the alloy. The molar volume of Ni-Cr alloy determinedin the present work shows a positive deviation from the linear molar volume.

  7. Leptin and bone mineral density

    DEFF Research Database (Denmark)

    Morberg, Cathrine M.; Tetens, Inge; Black, Eva

    2003-01-01

    Leptin has been suggested to decrease bone mineral density (BMD). This observational analysis explored the relationship between serum leptin and BMD in 327 nonobese men (controls) (body mass index 26.1 +/- 3.7 kg/m(2), age 49.9 +/- 6.0 yr) and 285 juvenile obese men (body mass index 35.9 +/- 5.9 kg...... males, but it also stresses the fact that the strong covariation between the examined variables is a shortcoming of the cross-sectional design....

  8. Age-related decrease in rod bipolar cell density of the human retina ...

    Indian Academy of Sciences (India)

    PRAKASH

    Retinal bipolar cells situated in the inner nuclear layer are predominantly involved in mediating the transfer of signals from the photoreceptors to the ganglion cells. Their synapses are located both at the level of the outer and inner plexiform layers. In the former, their dendritic processes synapse with photoreceptors in the ...

  9. Spatial mapping of humeral head bone density.

    Science.gov (United States)

    Alidousti, Hamidreza; Giles, Joshua W; Emery, Roger J H; Jeffers, Jonathan

    2017-09-01

    Short-stem humeral replacements achieve fixation by anchoring to the metaphyseal trabecular bone. Fixing the implant in high-density bone can provide strong fixation and reduce the risk of loosening. However, there is a lack of data mapping the bone density distribution in the proximal humerus. The aim of the study was to investigate the bone density in proximal humerus. Eight computed tomography scans of healthy cadaveric humeri were used to map bone density distribution in the humeral head. The proximal humeral head was divided into 12 slices parallel to the humeral anatomic neck. Each slice was then divided into 4 concentric circles. The slices below the anatomic neck, where short-stem implants have their fixation features, were further divided into radial sectors. The average bone density for each of these regions was calculated, and regions of interest were compared using a repeated-measures analysis of variance with significance set at P density was found to decrease from proximal to distal regions, with the majority of higher bone density proximal to the anatomic neck of the humerus (P density increases from central to peripheral regions, where cortical bone eventually occupies the space (P density distribution in the medial calcar region was also observed. This study indicates that it is advantageous with respect to implant fixation to preserve some bone above the anatomic neck and epiphyseal plate and to use the denser bone at the periphery. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  10. Magnetosheath density fluctuations and magnetopause motion

    Energy Technology Data Exchange (ETDEWEB)

    Sibeck, D.G. [Johns Hopkins Univ. Applied Physics Lab., Laurel, MD (United States); Gosling, J.T. [Los Alamos National Lab., NM (United States)

    1996-01-01

    The interplanetary magnetic field (IMF) orientation controls foreshock densities and modulates the fraction of the solar wind dynamic pressure applied to the magnetosphere. Such pressure variations produce bow shock and magnetopause motion and cause the radial profiles for various magnetosheath parameters to sweep inward and outward past nearly stationary satellites. The authors report ISEE 2 observations of correlated density and speed fluctuations, and anticorrelated density and temperature fluctuations, on an outbound pass through the northern dawnside magnetosheath. Densities decreased when the magnetic field rotated southward and draped about the magnetopause. In the absence of any significant solar wind density or dynamic pressure variations, they interpret the magnetosheath fluctuations as evidence for radial magnetosheath motion induced by variations in the IMF orientation. 41 refs., 8 figs.

  11. On density forecast evaluation

    NARCIS (Netherlands)

    Diks, C.

    2008-01-01

    Traditionally, probability integral transforms (PITs) have been popular means for evaluating density forecasts. For an ideal density forecast, the PITs should be uniformly distributed on the unit interval and independent. However, this is only a necessary condition, and not a sufficient one, as

  12. Learning Grasp Affordance Densities

    DEFF Research Database (Denmark)

    Detry, Renaud; Kraft, Dirk; Kroemer, Oliver

    2011-01-01

    and relies on kernel density estimation to provide a continuous model. Grasp densities are learned and refined from exploration, by letting a robot “play” with an object in a sequence of graspand-drop actions: The robot uses visual cues to generate a set of grasp hypotheses; it then executes......We address the issue of learning and representing object grasp affordance models. We model grasp affordances with continuous probability density functions (grasp densities) which link object-relative grasp poses to their success probability. The underlying function representation is nonparametric...... these and records their outcomes. When a satisfactory number of grasp data is available, an importance-sampling algorithm turns these into a grasp density. We evaluate our method in a largely autonomous learning experiment run on three objects of distinct shapes. The experiment shows how learning increases success...

  13. Jabuticaba [Pliniajaboticaba (Vell.) Berg] skins decrease lipid ...

    African Journals Online (AJOL)

    SAM

    2014-03-12

    density lipoprotein cholesterol; MDA, malondialdehyde ... rats, and quantification and characterization of its .... Moisture and lipid content were determined using the methods ... acids and flavonoids were identified, presenting the.

  14. Current density tensors

    Science.gov (United States)

    Lazzeretti, Paolo

    2018-04-01

    It is shown that nonsymmetric second-rank current density tensors, related to the current densities induced by magnetic fields and nuclear magnetic dipole moments, are fundamental properties of a molecule. Together with magnetizability, nuclear magnetic shielding, and nuclear spin-spin coupling, they completely characterize its response to magnetic perturbations. Gauge invariance, resolution into isotropic, deviatoric, and antisymmetric parts, and contributions of current density tensors to magnetic properties are discussed. The components of the second-rank tensor properties are rationalized via relationships explicitly connecting them to the direction of the induced current density vectors and to the components of the current density tensors. The contribution of the deviatoric part to the average value of magnetizability, nuclear shielding, and nuclear spin-spin coupling, uniquely determined by the antisymmetric part of current density tensors, vanishes identically. The physical meaning of isotropic and anisotropic invariants of current density tensors has been investigated, and the connection between anisotropy magnitude and electron delocalization has been discussed.

  15. Estruturação de um programa de qualificação em gestão da qualidade, segurança e saúde ocupacional: apresentação dos resultados de uma aplicação piloto realizada no aglomerado metal-mecânico de Sertãozinho - São Paulo Structuring a qualification program on quality, occupational health and safety management: presenting the results of a pilot application in the metal-mechanic cluster in Sertõzinho, São Paulo state, Brazil

    Directory of Open Access Journals (Sweden)

    Gislaine Aparecida Vitoreli

    2012-12-01

    Full Text Available Este artigo apresenta e discute a estruturação de um programa de qualificação para pequenas e médias empresas em gestão de qualidade, segurança e saúde ocupacional. O programa de qualificação proposto inclui a estruturação de um modelo de sistema de gestão integrado bem como a estruturação dos processos de implementação e auditoria deste sistema. O método de pesquisa-ação foi adotado para a condução da aplicação piloto desta proposta que foi realizada no aglomerado metal-mecânico de Sertãozinho, São Paulo. Os resultados preliminares da aplicação piloto apontam para possibilidade de operacionalização da proposta que pode contribuir em dois aspectos importantes: maior competitividade para as empresas do aglomerado e melhoria na competência da governança local em coordenar ações conjuntas. Ressalta-se ainda a existência de desafios para a continuidade do programa de qualificação, sendo a sua manutenção pela agência de coordenação local um dos mais críticos.This article aims to present and discuss the framework of a qualification program on quality, occupational health and safety management for small and medium sized enterprises. The proposed qualification program includes an integrated management system model, as well as a process for conducting periodic audits. Action research was the methodological approach chosen to conduct the pilot application of the proposed qualification program. The pilot application was performed with a group of small and medium enterprises of the Sertãozinho's metal-mechanic cluster, located in the state of São Paulo Preliminary results indicate the possibility of operationalization of the proposal as well as its contributions to two key aspects: increase competitiveness of the companies in the cluster and increase competence of the cluster governance team to coordinate joint actions. Nevertheless, there are great challenges to maintain the qualification program, and its

  16. Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans.

    NARCIS (Netherlands)

    Molteni, R.; Cattaneo, A.; Calabrese, F.; Macchi, F.; Olivier, J.D.A.; Racagni, G.; Ellenbroek, A.A.; Gennarelli, M.; Riva, M.A.

    2010-01-01

    In order to identify the molecular mechanisms that may contribute to the enhanced susceptibility to depression under serotonin transporter (SERT) dysfunction, we analyzed the expression of brain-derived neurotrophic factor (BDNF), a key player in neuronal plasticity, which is implicated in the

  17. Intrinsic-density functionals

    International Nuclear Information System (INIS)

    Engel, J.

    2007-01-01

    The Hohenberg-Kohn theorem and Kohn-Sham procedure are extended to functionals of the localized intrinsic density of a self-bound system such as a nucleus. After defining the intrinsic-density functional, we modify the usual Kohn-Sham procedure slightly to evaluate the mean-field approximation to the functional, and carefully describe the construction of the leading corrections for a system of fermions in one dimension with a spin-degeneracy equal to the number of particles N. Despite the fact that the corrections are complicated and nonlocal, we are able to construct a local Skyrme-like intrinsic-density functional that, while different from the exact functional, shares with it a minimum value equal to the exact ground-state energy at the exact ground-state intrinsic density, to next-to-leading order in 1/N. We briefly discuss implications for real Skyrme functionals

  18. Density functional theory

    International Nuclear Information System (INIS)

    Das, M.P.

    1984-07-01

    The state of the art of the density functional formalism (DFT) is reviewed. The theory is quantum statistical in nature; its simplest version is the well-known Thomas-Fermi theory. The DFT is a powerful formalism in which one can treat the effect of interactions in inhomogeneous systems. After some introductory material, the DFT is outlined from the two basic theorems, and various generalizations of the theorems appropriate to several physical situations are pointed out. Next, various approximations to the density functionals are presented and some practical schemes, discussed; the approximations include an electron gas of almost constant density and an electron gas of slowly varying density. Then applications of DFT in various diverse areas of physics (atomic systems, plasmas, liquids, nuclear matter) are mentioned, and its strengths and weaknesses are pointed out. In conclusion, more recent developments of DFT are indicated

  19. Low Density Supersonic Decelerators

    Data.gov (United States)

    National Aeronautics and Space Administration — The Low-Density Supersonic Decelerator project will demonstrate the use of inflatable structures and advanced parachutes that operate at supersonic speeds to more...

  20. density functional theory approach

    Indian Academy of Sciences (India)

    YOGESH ERANDE

    2017-07-27

    Jul 27, 2017 ... a key role in all optical switching devices, since their optical properties can be .... optimized in the gas phase using Density Functional Theory. (DFT).39 The ...... The Mediation of Electrostatic Effects by Sol- vents J. Am. Chem.

  1. Bone mineral density test

    Science.gov (United States)

    BMD test; Bone density test; Bone densitometry; DEXA scan; DXA; Dual-energy x-ray absorptiometry; p-DEXA; Osteoporosis - BMD ... need to undress. This scan is the best test to predict your risk of fractures, especially of ...

  2. Density scaling for multiplets

    International Nuclear Information System (INIS)

    Nagy, A

    2011-01-01

    Generalized Kohn-Sham equations are presented for lowest-lying multiplets. The way of treating non-integer particle numbers is coupled with an earlier method of the author. The fundamental quantity of the theory is the subspace density. The Kohn-Sham equations are similar to the conventional Kohn-Sham equations. The difference is that the subspace density is used instead of the density and the Kohn-Sham potential is different for different subspaces. The exchange-correlation functional is studied using density scaling. It is shown that there exists a value of the scaling factor ζ for which the correlation energy disappears. Generalized OPM and Krieger-Li-Iafrate (KLI) methods incorporating correlation are presented. The ζKLI method, being as simple as the original KLI method, is proposed for multiplets.

  3. Fission level densities

    International Nuclear Information System (INIS)

    Maslov, V.M.

    1998-01-01

    Fission level densities (or fissioning nucleus level densities at fission saddle deformations) are required for statistical model calculations of actinide fission cross sections. Back-shifted Fermi-Gas Model, Constant Temperature Model and Generalized Superfluid Model (GSM) are widely used for the description of level densities at stable deformations. These models provide approximately identical level density description at excitations close to the neutron binding energy. It is at low excitation energies that they are discrepant, while this energy region is crucial for fission cross section calculations. A drawback of back-shifted Fermi gas model and traditional constant temperature model approaches is that it is difficult to include in a consistent way pair correlations, collective effects and shell effects. Pair, shell and collective properties of nucleus do not reduce just to the renormalization of level density parameter a, but influence the energy dependence of level densities. These effects turn out to be important because they seem to depend upon deformation of either equilibrium or saddle-point. These effects are easily introduced within GSM approach. Fission barriers are another key ingredients involved in the fission cross section calculations. Fission level density and barrier parameters are strongly interdependent. This is the reason for including fission barrier parameters along with the fission level densities in the Starter File. The recommended file is maslov.dat - fission barrier parameters. Recent version of actinide fission barrier data obtained in Obninsk (obninsk.dat) should only be considered as a guide for selection of initial parameters. These data are included in the Starter File, together with the fission barrier parameters recommended by CNDC (beijing.dat), for completeness. (author)

  4. Density-wave oscillations

    International Nuclear Information System (INIS)

    Belblidia, L.A.; Bratianu, C.

    1979-01-01

    Boiling flow in a steam generator, a water-cooled reactor, and other multiphase processes can be subject to instabilities. It appears that the most predominant instabilities are the so-called density-wave oscillations. They can cause difficulties for three main reasons; they may induce burnout; they may cause mechanical vibrations of components; and they create system control problems. A comprehensive review is presented of experimental and theoretical studies concerning density-wave oscillations. (author)

  5. Density of liquid Ytterbium

    International Nuclear Information System (INIS)

    Stankus, S.V.; Basin, A.S.

    1983-01-01

    Results are presented for measurements of the density of metallic ytterbium in the liquid state and at the liquid-solid phase transition. Based on the numerical data obtained, the coefficient of thermal expansion βZ of the liquid and the density discontinuity on melting deltarho/sub m/ are calculated. The magnitudes of βZ and deltarho/sub m/ for the heavy lanthanides are compared

  6. Clustering phenomena in nuclear matter below the saturation density

    International Nuclear Information System (INIS)

    Takemoto, Hiroki; Fukushima, Masahiro; Chiba, Satoshi; Horiuchi, Hisashi; Akaishi, Yoshinori; Tohsaki, Akihiro

    2004-01-01

    We investigate density-fluctuated states of nuclear matter as a result of clustering below the saturation density ρ 0 by description in terms of the Bloch function. The Bloch description has the advantage of a unified representation for a density-fluctuated state from an aggregate of uncorrelated clusters in extremely low-density regions to the plane-wave state of uniform matter in relatively high-density regions. We treat the density-fluctuated states due to α and 16 O clustering in symmetric nuclear matter and due to 10 He clustering in asymmetric nuclear matter. The density-fluctuated states develop as the density of matter decreases below each critical density around 0.2-0.4 ρ 0 which depends on what kind of effective force we use

  7. Disruption of mammalian target of rapamycin complex 1 in macrophages decreases chemokine gene expression and atherosclerosis

    NARCIS (Netherlands)

    Ai, Ding; Jiang, Hongfeng; Westerterp, Marit; Murphy, Andrew J.; Wang, Mi; Ganda, Anjali; Abramowicz, Sandra; Welch, Carrie; Almazan, Felicidad; Zhu, Yi; Miller, Yury I.; Tall, Alan R.

    2014-01-01

    The mammalian target of rapamycin complex 1 inhibitor, rapamycin, has been shown to decrease atherosclerosis, even while increasing plasma low-density lipoprotein levels. This suggests an antiatherogenic effect possibly mediated by the modulation of inflammatory responses in atherosclerotic plaques.

  8. Negative Ion Density Fronts

    International Nuclear Information System (INIS)

    Igor Kaganovich

    2000-01-01

    Negative ions tend to stratify in electronegative plasmas with hot electrons (electron temperature Te much larger than ion temperature Ti, Te > Ti ). The boundary separating a plasma containing negative ions, and a plasma, without negative ions, is usually thin, so that the negative ion density falls rapidly to zero-forming a negative ion density front. We review theoretical, experimental and numerical results giving the spatio-temporal evolution of negative ion density fronts during plasma ignition, the steady state, and extinction (afterglow). During plasma ignition, negative ion fronts are the result of the break of smooth plasma density profiles during nonlinear convection. In a steady-state plasma, the fronts are boundary layers with steepening of ion density profiles due to nonlinear convection also. But during plasma extinction, the ion fronts are of a completely different nature. Negative ions diffuse freely in the plasma core (no convection), whereas the negative ion front propagates towards the chamber walls with a nearly constant velocity. The concept of fronts turns out to be very effective in analysis of plasma density profile evolution in strongly non-isothermal plasmas

  9. Density and surface tension of ionic liquids.

    Science.gov (United States)

    Kolbeck, C; Lehmann, J; Lovelock, K R J; Cremer, T; Paape, N; Wasserscheid, P; Fröba, A P; Maier, F; Steinrück, H-P

    2010-12-30

    We measured the density and surface tension of 9 bis[(trifluoromethyl)sulfonyl]imide ([Tf(2)N](-))-based and 12 1-methyl-3-octylimidazolium ([C(8)C(1)Im](+))-based ionic liquids (ILs) with the vibrating tube and the pendant drop method, respectively. This comprehensive set of ILs was chosen to probe the influence of the cations and anions on density and surface tension. When the alkyl chain length in the [C(n)C(1)Im][Tf(2)N] series (n = 1, 2, 4, 6, 8, 10, 12) is increased, a decrease in density is observed. The surface tension initially also decreases but reaches a plateau for alkyl chain lengths greater than n = 8. Functionalizing the alkyl chains with ethylene glycol groups results in a higher density as well as a higher surface tension. For the dependence of density and surface tension on the chemical nature of the anion, relations are only found for subgroups of the studied ILs. Density and surface tension values are discussed with respect to intermolecular interactions and surface composition as determined by angle-resolved X-ray photoelectron spectroscopy (ARXPS). The absence of nonvolatile surface-active contaminants was proven by ARXPS.

  10. Phalangeal bone mineral density predicts incident fractures

    DEFF Research Database (Denmark)

    Friis-Holmberg, Teresa; Brixen, Kim; Rubin, Katrine Hass

    2012-01-01

    This prospective study investigates the use of phalangeal bone mineral density (BMD) in predicting fractures in a cohort (15,542) who underwent a BMD scan. In both women and men, a decrease in BMD was associated with an increased risk of fracture when adjusted for age and prevalent fractures...

  11. ESTIMATION OF THE DECREASING OF 137 CS SEDIMENT IN THE SOIL DUE TO HORIZONTAL FLOWING

    Directory of Open Access Journals (Sweden)

    O. N. Prokof'ev

    2008-01-01

    Full Text Available The purpose of work is to estimate the possible decreasing of the density of  137 Cs sediment in the soil influenced by the horizontal flowing basing on the analysis of on location observations on the density of  137 Cs sediment in the soil after the Chernobyl accident.

  12. Condensation energy density in Bi-2212 superconductors

    International Nuclear Information System (INIS)

    Matsushita, Teruo; Kiuchi, Masaru; Haraguchi, Teruhisa; Imada, Takeki; Okamura, Kazunori; Okayasu, Satoru; Uchida, Satoshi; Shimoyama, Jun-ichi; Kishio, Kohji

    2006-01-01

    The relationship between the condensation energy density and the anisotropy parameter, γ a , has been derived for Bi-2212 superconductors in various anisotropic states by analysing the critical current density due to columnar defects introduced by heavy ion irradiation. The critical current density depended on the size of the defects, determined by the kind and irradiation energy of the ions. A significantly large critical current density of 17.0 MA cm -2 was obtained at 5 K and 0.1 T even for the defect density of a matching field of 1 T in a specimen irradiated with iodine ions. The dependence of the critical current density on the size of the defects agreed well with the prediction from the summation theory of pinning forces, and the condensation energy density could be obtained consistently from specimens irradiated with different ions. The condensation energy density obtained increased with decreasing γ a over the entire range of measurement temperature, and reached about 60% of the value for the most three-dimensional Y-123 observed by Civale et al at 5 K. This gives the reason for the very strong pinning in Bi-2212 superconductors at low temperatures. The thermodynamic critical field obtained decreased linearly with increasing temperature and extrapolated to zero at a certain characteristic temperature, T * , lower than the critical temperature, T c . T * , which seems to be associated with the superconductivity in the block layers, was highest for the optimally doped specimen. This shows that the superconductivity becomes more inhomogeneous as the doped state of a superconductor deviates from the optimum condition

  13. Density Variations in the Earth's Magnetospheric Cusps

    Science.gov (United States)

    Walsh, B. M.; Niehof, J.; Collier, M. R.; Welling, D. T.; Sibeck, D. G.; Mozer, F. S.; Fritz, T. A.; Kuntz, K. D.

    2016-01-01

    Seven years of measurements from the Polar spacecraft are surveyed to monitor the variations of plasma density within the magnetospheric cusps. The spacecraft's orbital precession from 1998 through 2005 allows for coverage of both the northern and southern cusps from low altitude out to the magnetopause. In the mid- and high- altitude cusps, plasma density scales well with the solar wind density (n(sub cusp)/n(sub sw) approximately 0.8). This trend is fairly steady for radial distances greater then 4 R(sub E). At low altitudes (r less than 4R(sub E)) the density increases with decreasing altitude and even exceeds the solar wind density due to contributions from the ionosphere. The density of high charge state oxygen (O(greater +2) also displays a positive trend with solar wind density within the cusp. A multifluid simulation with the Block-Adaptive-Tree Solar Wind Roe-Type Upwind Scheme MHD model was run to monitor the relative contributions of the ionosphere and solar wind plasma within the cusp. The simulation provides similar results to the statistical measurements from Polar and confirms the presence of ionospheric plasma at low altitudes.

  14. Tyrosine Phosphorylation of the Human Serotonin Transporter: A Role in the Transporter Stability and Function

    Science.gov (United States)

    Annamalai, Balasubramaniam; Mannangatti, Padmanabhan; Arapulisamy, Obulakshmi; Shippenberg, Toni S.; Jayanthi, Lankupalle D.

    2012-01-01

    The serotonin (5-HT) transporter (SERT) regulates serotoninergic neurotransmission by clearing 5-HT released into the synaptic space. Phosphorylation of SERT on serine and threonine mediates SERT regulation. Whether tyrosine phosphorylation regulates SERT is unknown. Here, we tested the hypothesis that tyrosine-phosphorylation of SERT regulates 5-HT transport. In support of this, alkali-resistant 32P-labeled SERT was found in rat platelets, and Src-tyrosine kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo [3,4,d]pyrimidine (PP2) decreased platelet SERT function and expression. In human placental trophoblast cells expressing SERT, PP2 reduced transporter function, expression, and stability. Although siRNA silencing of Src expression decreased SERT function and expression, coexpression of Src resulted in PP2-sensitive increases in SERT function and expression. PP2 treatment markedly decreased SERT protein stability. Compared with WT-SERT, SERT tyrosine mutants Y47F and Y142F exhibited reduced 5-HT transport despite their higher total and cell surface expression levels. Moreover, Src-coexpression increased total and cell surface expression of Y47F and Y142F SERT mutants without affecting their 5-HT transport capacity. It is noteworthy that Y47F and Y142F mutants exhibited higher protein stability compared with WT-SERT. However, similar to WT-SERT, PP2 treatment decreased the stability of Y47F and Y142F mutants. Furthermore, compared with WT-SERT, Y47F and Y142F mutants exhibited lower basal tyrosine phosphorylation and no further enhancement of tyrosine phosphorylation in response to Src coexpression. These results provide the first evidence that SERT tyrosine phosphorylation supports transporter protein stability and 5HT transport. PMID:21992875

  15. CRISS power spectral density

    International Nuclear Information System (INIS)

    Vaeth, W.

    1979-04-01

    The correlation of signal components at different frequencies like higher harmonics cannot be detected by a normal power spectral density measurement, since this technique correlates only components at the same frequency. This paper describes a special method for measuring the correlation of two signal components at different frequencies: the CRISS power spectral density. From this new function in frequency analysis, the correlation of two components can be determined quantitatively either they stem from one signal or from two diverse signals. The principle of the method, suitable for the higher harmonics of a signal as well as for any other frequency combinations is shown for the digital frequency analysis technique. Two examples of CRISS power spectral densities demonstrates the operation of the new method. (orig.) [de

  16. High density dispersion fuel

    International Nuclear Information System (INIS)

    Hofman, G.L.

    1996-01-01

    A fuel development campaign that results in an aluminum plate-type fuel of unlimited LEU burnup capability with an uranium loading of 9 grams per cm 3 of meat should be considered an unqualified success. The current worldwide approved and accepted highest loading is 4.8 g cm -3 with U 3 Si 2 as fuel. High-density uranium compounds offer no real density advantage over U 3 Si 2 and have less desirable fabrication and performance characteristics as well. Of the higher-density compounds, U 3 Si has approximately a 30% higher uranium density but the density of the U 6 X compounds would yield the factor 1.5 needed to achieve 9 g cm -3 uranium loading. Unfortunately, irradiation tests proved these peritectic compounds have poor swelling behavior. It is for this reason that the authors are turning to uranium alloys. The reason pure uranium was not seriously considered as a dispersion fuel is mainly due to its high rate of growth and swelling at low temperatures. This problem was solved at least for relatively low burnup application in non-dispersion fuel elements with small additions of Si, Fe, and Al. This so called adjusted uranium has nearly the same density as pure α-uranium and it seems prudent to reconsider this alloy as a dispersant. Further modifications of uranium metal to achieve higher burnup swelling stability involve stabilization of the cubic γ phase at low temperatures where normally α phase exists. Several low neutron capture cross section elements such as Zr, Nb, Ti and Mo accomplish this in various degrees. The challenge is to produce a suitable form of fuel powder and develop a plate fabrication procedure, as well as obtain high burnup capability through irradiation testing

  17. Gap and density theorems

    CERN Document Server

    Levinson, N

    1940-01-01

    A typical gap theorem of the type discussed in the book deals with a set of exponential functions { \\{e^{{{i\\lambda}_n} x}\\} } on an interval of the real line and explores the conditions under which this set generates the entire L_2 space on this interval. A typical gap theorem deals with functions f on the real line such that many Fourier coefficients of f vanish. The main goal of this book is to investigate relations between density and gap theorems and to study various cases where these theorems hold. The author also shows that density- and gap-type theorems are related to various propertie

  18. Nuclear level density

    International Nuclear Information System (INIS)

    Cardoso Junior, J.L.

    1982-10-01

    Experimental data show that the number of nuclear states increases rapidly with increasing excitation energy. The properties of highly excited nuclei are important for many nuclear reactions, mainly those that go via processes of the compound nucleus type. In this case, it is sufficient to know the statistical properties of the nuclear levels. First of them is the function of nuclear levels density. Several theoretical models which describe the level density are presented. The statistical mechanics and a quantum mechanics formalisms as well as semi-empirical results are analysed and discussed. (Author) [pt

  19. Polarizable Density Embedding

    DEFF Research Database (Denmark)

    Olsen, Jógvan Magnus Haugaard; Steinmann, Casper; Ruud, Kenneth

    2015-01-01

    We present a new QM/QM/MM-based model for calculating molecular properties and excited states of solute-solvent systems. We denote this new approach the polarizable density embedding (PDE) model and it represents an extension of our previously developed polarizable embedding (PE) strategy. The PDE...... model is a focused computational approach in which a core region of the system studied is represented by a quantum-chemical method, whereas the environment is divided into two other regions: an inner and an outer region. Molecules belonging to the inner region are described by their exact densities...

  20. Holographic magnetisation density waves

    Energy Technology Data Exchange (ETDEWEB)

    Donos, Aristomenis [Centre for Particle Theory and Department of Mathematical Sciences, Durham University,Stockton Road, Durham, DH1 3LE (United Kingdom); Pantelidou, Christiana [Departament de Fisica Quantica i Astrofisica & Institut de Ciencies del Cosmos (ICC),Universitat de Barcelona,Marti i Franques 1, 08028 Barcelona (Spain)

    2016-10-10

    We numerically construct asymptotically AdS black brane solutions of D=4 Einstein theory coupled to a scalar and two U(1) gauge fields. The solutions are holographically dual to d=3 CFTs in a constant external magnetic field along one of the U(1)’s. Below a critical temperature the system’s magnetisation density becomes inhomogeneous, leading to spontaneous formation of current density waves. We find that the transition can be of second order and that the solutions which minimise the free energy locally in the parameter space of solutions have averaged stressed tensor of a perfect fluid.

  1. Grazing disturbance increases transient but decreases persistent soil seed bank.

    Science.gov (United States)

    Ma, Miaojun; Walck, Jeffrey L; Ma, Zhen; Wang, Lipei; Du, Guozhen

    2018-04-30

    Very few studies have examined whether the impacts of grazing disturbance on soil seed banks occur directly or indirectly through aboveground vegetation and soil properties. The potential role of the seed bank in alpine wetland restoration is also unknown. We used SEM (structural equation modeling) to explore the direct effect of grazing disturbance on the seed bank and the indirect effect through aboveground vegetation and soil properties. We also studied the role of the seed bank on the restoration potential in wetlands with various grazing intensities: low (fenced, winter grazed only), medium (seasonally grazed), and high (whole-year grazed). For the seed bank, species richness and density per plot showed no difference among grazing intensities for each depth (0-5, 5-10, 10-15 cm) and for the whole depth (0-15 cm) in spring and summer. There was no direct effect of grazing disturbance on seed bank richness and density both in spring and summer, and also no indirect effect on the seed bank through its direct effect on vegetation richness and abundance. Grazing disturbance indirectly increased spring seed bank density but decreased summer seed bank density through its direct effect (negative correlation) on soil moisture and total nitrogen and its indirect effect on vegetation abundance. Species composition of the vegetation changed with grazing regime, but that of the seed bank did not. An increased trend of similarity between the seed bank and aboveground vegetation with increased grazing disturbance was found in the shallow depth and in the whole depth only in spring. Although there was almost no change in seed bank size with grazing intensities, grazing disturbance increased the quantity of transient seeds but decreased persistent seeds. Persistent seeds stored in the soil could play a crucial role in vegetation regeneration and in restoration of degraded wetland ecosystems. The seed bank should be an integral part of alpine wetland restoration programs.

  2. Spontaneous entropy decrease and its statistical formula

    OpenAIRE

    Xing, Xiu-San

    2007-01-01

    Why can the world resist the law of entropy increase and produce self-organizing structure? Does the entropy of an isolated system always only increase and never decrease? Can be thermodymamic degradation and self-organizing evolution united? How to unite? In this paper starting out from nonequilibrium entropy evolution equation we proved that a new entropy decrease could spontaneously emerge in nonequilibrium system with internal attractive interaction. This new entropy decrease coexists wit...

  3. A Tryst With Density

    Indian Academy of Sciences (India)

    best known for developing the density functional theory (DFT). This is an extremely ... lem that has become famous in popular culture is that of the planet. Tatooine. Fans of ... the Schrödinger equation (or, if relativistic effects are important, the Dirac .... it supplies a moral justification for one's subsequent endeav- ours along ...

  4. Density in Liquids.

    Science.gov (United States)

    Nesin, Gert; Barrow, Lloyd H.

    1984-01-01

    Describes a fourth-grade unit on density which introduces a concept useful in the study of chemistry and procedures appropriate to the chemistry laboratory. The hands-on activities, which use simple equipment and household substances, are at the level of thinking Piaget describes as concrete operational. (BC)

  5. Destiny from density

    OpenAIRE

    Seewaldt, Victoria L.

    2012-01-01

    The identification of a signalling protein that regulates the accumulation of fat and connective tissue in breasts may help to explain why high mammographic density is linked to breast-cancer risk and may provide a marker for predicting this risk.

  6. Polarizable Density Embedding

    DEFF Research Database (Denmark)

    Reinholdt, Peter; Kongsted, Jacob; Olsen, Jógvan Magnus Haugaard

    2017-01-01

    We analyze the performance of the polarizable density embedding (PDE) model-a new multiscale computational approach designed for prediction and rationalization of general molecular properties of large and complex systems. We showcase how the PDE model very effectively handles the use of large...

  7. Use of biofuels in road transport decreases

    International Nuclear Information System (INIS)

    Segers, R.

    2011-01-01

    The use of biofuels decreased from 3.5 percent, for all gasoline and diesel used by road transport in 2009, to 2 percent in 2010. Particularly the use of biodiesel decreased, dropping from 3.5 to 1.5 percent. The use of biogasoline remained stable, catering for 3 percent of all gasoline use. [nl

  8. Mastery Learning and the Decreasing Variability Hypothesis.

    Science.gov (United States)

    Livingston, Jennifer A.; Gentile, J. Ronald

    1996-01-01

    This report results from studies that tested two variations of Bloom's decreasing variability hypothesis using performance on successive units of achievement in four graduate classrooms that used mastery learning procedures. Data do not support the decreasing variability hypothesis; rather, they show no change over time. (SM)

  9. Evaluation of reference evapotranspiration by Penman-Monteith using minimum climatic data in the backcountry of Ceará = Avaliação da evapotranspiração de referência por Penman-Monteith usando dados climáticos mínimos no sertão do Ceará

    Directory of Open Access Journals (Sweden)

    Mairton Gomes da Silva

    2013-12-01

    Full Text Available In areas of semiarid climate, water resources are limited and seriously threatened by excessive exploitation. This study’s objective is to evaluate the performance of the method FAO 56 Penman-Monteith (PM-FAO 56 to estimate the reference evapotranspiration (ETo with minimum data (maximum and minimum air temperature in the backcountry of the state of Ceará. The work was developed based on maximum and minimum air temperatures, relative air humidity, wind speed, and insolation of the conventional stations of the backcountry of Ceará, obtained from the National Institute of Meteorology (INMET. To compare the values of ETo estimated by FAO PM-56 with complete data where the minimum was considered the ratio between the mean (ξ, the standard error of estimation (SEE, correlation coefficient (r, accuracy or concordance index (d and performance or confidence index (c. Maps of ETo by PM-FAO 56 were made with minimum data for the mesoregion of the backcountry of Ceara, by means of the inverse distance weighted (IDW. The following of estimates of ETo by PM-FAO 56 with maximum and minimum air temperatures worked satisfactorily and by means of spatialisation and generation of thematic maps, it was possible to visualize the ETo in the most remote areas of the region of the study. = Nas regiões de clima semiárido os recursos hídricos são limitados e seriamente ameaçados pela excessiva exploração. Objetivou-se com este estudo avaliar o desempenho do método Penman-Monteith FAO 56 (PM-FAO 56 para estimar a evapotranspiração de referência (ETo com dados mínimos (temperatura máxima e mínima do ar, no sertão do estado do Ceará. O trabalho foi desenvolvido a partir de dados de temperatura máxima e mínima do ar, umidade relativa do ar, velocidade do vento e insolação das estações convencionais da região do sertão cearense, obtidos com o Instituto Nacional de Meteorologia (INMET. Para comparar os valores de ETo estimados por PM-FAO 56 com

  10. Comparison of low density and high density pedicle screw instrumentation in Lenke 1 adolescent idiopathic scoliosis.

    Science.gov (United States)

    Shen, Mingkui; Jiang, Honghui; Luo, Ming; Wang, Wengang; Li, Ning; Wang, Lulu; Xia, Lei

    2017-08-02

    The correlation between implant density and deformity correction has not yet led to a precise conclusion in adolescent idiopathic scoliosis (AIS). The aim of this study was to evaluate the effects of low density (LD) and high density (HD) pedicle screw instrumentation in terms of the clinical, radiological and Scoliosis Research Society (SRS)-22 outcomes in Lenke 1 AIS. We retrospectively reviewed 62 consecutive Lenke 1 AIS patients who underwent posterior spinal arthrodesis using all-pedicle screw instrumentation with a minimum follow-up of 24 months. The implant density was defined as the number of screws per spinal level fused. Patients were then divided into two groups according to the average implant density for the entire study. The LD group (n = 28) had fewer than 1.61 screws per level, while the HD group (n = 34) had more than 1.61 screws per level. The radiographs were analysed preoperatively, postoperatively and at final follow-up. The perioperative and SRS-22 outcomes were also assessed. Independent sample t tests were used between the two groups. Comparisons between the two groups showed no significant differences in the correction of the main thoracic curve and thoracic kyphosis, blood transfusion, hospital stay, and SRS-22 scores. Compared with the HD group, there was a decreased operating time (278.4 vs. 331.0 min, p = 0.004) and decreased blood loss (823.6 vs. 1010.9 ml, p = 0.048), pedicle screws needed (15.1 vs. 19.6, p density and high density pedicle screw instrumentation achieved satisfactory deformity correction in Lenke 1 AIS patients. However, the operating time and blood loss were reduced, and the implant costs were decreased with the use of low screw density constructs.

  11. Weight loss and bone mineral density.

    Science.gov (United States)

    Hunter, Gary R; Plaisance, Eric P; Fisher, Gordon

    2014-10-01

    Despite evidence that energy deficit produces multiple physiological and metabolic benefits, clinicians are often reluctant to prescribe weight loss in older individuals or those with low bone mineral density (BMD), fearing BMD will be decreased. Confusion exists concerning the effects that weight loss has on bone health. Bone density is more closely associated with lean mass than total body mass and fat mass. Although rapid or large weight loss is often associated with loss of bone density, slower or smaller weight loss is much less apt to adversely affect BMD, especially when it is accompanied with high intensity resistance and/or impact loading training. Maintenance of calcium and vitamin D intake seems to positively affect BMD during weight loss. Although dual energy X-ray absorptiometry is normally used to evaluate bone density, it may overestimate BMD loss following massive weight loss. Volumetric quantitative computed tomography may be more accurate for tracking bone density changes following large weight loss. Moderate weight loss does not necessarily compromise bone health, especially when exercise training is involved. Training strategies that include heavy resistance training and high impact loading that occur with jump training may be especially productive in maintaining, or even increasing bone density with weight loss.

  12. On Improving Convergence Rates for Nonnegative Kernel Density Estimators

    OpenAIRE

    Terrell, George R.; Scott, David W.

    1980-01-01

    To improve the rate of decrease of integrated mean square error for nonparametric kernel density estimators beyond $0(n^{-\\frac{4}{5}}),$ we must relax the constraint that the density estimate be a bonafide density function, that is, be nonnegative and integrate to one. All current methods for kernel (and orthogonal series) estimators relax the nonnegativity constraint. In this paper we show how to achieve similar improvement by relaxing the integral constraint only. This is important in appl...

  13. Density and Structure Analysis of Molten Ni-W Alloys

    Institute of Scientific and Technical Information of China (English)

    Feng XIAO; Liang FANG

    2004-01-01

    Density of molten Ni and Ni-W alloys was measured in the temperature range of 1773~1873 K with a sessile drop method.The density of molten Ni and Ni-W alloys trends to decrease with increasing temperature. The density and molar volume of the alloys trend to increase with increasing W concentration in the alloys. The calculation result shows an ideal mixing of Ni-W alloys.

  14. Density and mechanical properties of calcium aluminate cement

    Science.gov (United States)

    Ahmed, Syed Taqi Uddin; Ahmmad, Shaik Kareem

    2018-04-01

    Calcium aluminate cements are a special type of cements which have their composition mainly dominated by the presence of Monocalcium Aluminates. In the present paper for the first time we have shown theoretical density and elastic constants for various calcium aluminate cements. The density of the present CAS decrease with aluminates presents in the cement. Using the density data, the elastic moduli namely Young's modulus, bulk and shear modulus show strong linear dependence as a function of compositional parameter.

  15. Quantal density functional theory

    CERN Document Server

    Sahni, Viraht

    2016-01-01

    This book deals with quantal density functional theory (QDFT) which is a time-dependent local effective potential theory of the electronic structure of matter. The treated time-independent QDFT constitutes a special case. In the 2nd edition, the theory is extended to include the presence of external magnetostatic fields. The theory is a description of matter based on the ‘quantal Newtonian’ first and second laws which is in terms of “classical” fields that pervade all space, and their quantal sources. The fields, which are explicitly defined, are separately representative of electron correlations due to the Pauli exclusion principle, Coulomb repulsion, correlation-kinetic, correlation-current-density, and correlation-magnetic effects. The book further describes Schrödinger theory from the new physical perspective of fields and quantal sources. It also describes traditional Hohenberg-Kohn-Sham DFT, and explains via QDFT the physics underlying the various energy functionals and functional derivatives o...

  16. Density dependent effective interactions

    International Nuclear Information System (INIS)

    Dortmans, P.J.; Amos, K.

    1994-01-01

    An effective nucleon-nucleon interaction is defined by an optimal fit to select on-and half-off-of-the-energy shell t-and g-matrices determined by solutions of the Lippmann-Schwinger and Brueckner-Bethe-Goldstone equations with the Paris nucleon-nucleon interaction as input. As such, it is seen to better reproduce the interaction on which it is based than other commonly used density dependent effective interactions. The new (medium modified) effective interaction when folded with appropriate density matrices, has been used to define proton- 12 C and proton- 16 O optical potentials. With them elastic scattering data are well fit and the medium effects identifiable. 23 refs., 8 figs

  17. Viscosity and density models for copper electrorefining electrolytes

    OpenAIRE

    Kalliomäki Taina; Aji Arif T.; Aromaa Jari; Lundström Mari

    2016-01-01

    Viscosity and density are highly important physicochemical properties of copper electrolyte since they affect the purity of cathode copper and energy consumption [1, 2] affecting the mass and heat transfer conditions in the cell [3]. Increasing viscosity and density decreases the rate in which the anode slime falls to the bottom of the cell [4, 5] and lowers the diffusion coefficient of cupric ion (DCu2+) [6]. Decreasing the falling rate of anode slime increases movement of the slime to other...

  18. Variable Kernel Density Estimation

    OpenAIRE

    Terrell, George R.; Scott, David W.

    1992-01-01

    We investigate some of the possibilities for improvement of univariate and multivariate kernel density estimates by varying the window over the domain of estimation, pointwise and globally. Two general approaches are to vary the window width by the point of estimation and by point of the sample observation. The first possibility is shown to be of little efficacy in one variable. In particular, nearest-neighbor estimators in all versions perform poorly in one and two dimensions, but begin to b...

  19. Density oscillations within hadrons

    International Nuclear Information System (INIS)

    Arnold, R.; Barshay, S.

    1976-01-01

    In models of extended hadrons, in which small bits of matter carrying charge and effective mass exist confined within a medium, oscillations in the matter density may occur. A way of investigating this possibility experimentally in high-energy hadron-hadron elastic diffraction scattering is suggested, and the effect is illustrated by examining some existing data which might be relevant to the question [fr

  20. Observed Decrease of North American Winter Temperature Variability

    Science.gov (United States)

    Rhines, A. N.; Tingley, M.; McKinnon, K. A.; Huybers, P. J.

    2015-12-01

    There is considerable interest in determining whether temperature variability has changed in recent decades. Model ensembles project that extratropical land temperature variance will detectably decrease by 2070. We use quantile regression of station observations to show that decreasing variability is already robustly detectable for North American winter during 1979--2014. Pointwise trends from GHCND stations are mapped into a continuous spatial field using thin-plate spline regression, resolving small-scales while providing uncertainties accounting for spatial covariance and varying station density. We find that variability of daily temperatures, as measured by the difference between the 95th and 5th percentiles, has decreased markedly in winter for both daily minima and maxima. Composites indicate that the reduced spread of winter temperatures primarily results from Arctic amplification decreasing the meridional temperature gradient. Greater observed warming in the 5th relative to the 95th percentile stems from asymmetric effects of advection during cold versus warm days; cold air advection is generally from northerly regions that have experienced greater warming than western or southwestern regions that are generally sourced during warm days.

  1. Toward a Redefinition of Density

    Science.gov (United States)

    Rapoport, Amos

    1975-01-01

    This paper suggests that in addition to the recent work indicating that crowding is a subjective phenomenon, an adequate definition of density must also include a subjective component since density is a complex phenomenon in itself. Included is a discussion of both physical density and perceived density. (Author/MA)

  2. Density measures and additive property

    OpenAIRE

    Kunisada, Ryoichi

    2015-01-01

    We deal with finitely additive measures defined on all subsets of natural numbers which extend the asymptotic density (density measures). We consider a class of density measures which are constructed from free ultrafilters on natural numbers and study a certain additivity property of such density measures.

  3. Can Diuretics Decrease Your Potassium Level?

    Science.gov (United States)

    ... of low potassium? Can diuretics decrease your potassium level? Answers from Sheldon G. Sheps, M.D. Yes, ... your urine. This can lead to low potassium levels in your blood (hypokalemia). Signs and symptoms of ...

  4. Using a Nonaversive Procedure to Decrease Refusals.

    Science.gov (United States)

    Spooner, Fred; And Others

    1990-01-01

    A nonaversive technique was used to teach a severely handicapped woman to decrease her refusals. The technique employed precision teaching via precise daily measurement strategies, environmental analysis, and a focus on building appropriate behavior. (JDD)

  5. Autoimmune Response Confers Decreased Cardiac Function in ...

    African Journals Online (AJOL)

    inflammatory response; rather, autoimmune response would keep affecting decreased heart function in. RHD patients who ... untreated children. Nearly 30 - 45 % of the affected children could ..... Technology Department of Anhui Province (PR.

  6. Guilt decreasing marketing communication: an unexplored appeal

    OpenAIRE

    B. BUSACCA; SOSCIA I; PITRELLI E

    2007-01-01

    The phenomenon of guilt is relevant to a variety of consumption situations and practitioners around the world have continued to use it as a communication appeal. Marketing literature demonstrated that guilt as a distinct emotion can be aroused by advertising. Nevertheless, the capacity of advertising to decrease guilt was neglected by marketing scholars and the aim of this research is to assess the role of the guilt decreasing appeal in reducing anticipated guilt. Findings demonstrate the eff...

  7. Decreased serum vitamin D in idiopathic benign paroxysmal positional vertigo.

    Science.gov (United States)

    Jeong, Seong-Hae; Kim, Ji-Soo; Shin, Jong Wook; Kim, Sungbo; Lee, Hajeong; Lee, Ae Young; Kim, Jae-Moon; Jo, Hyunjin; Song, Junghan; Ghim, Yuna

    2013-03-01

    Previous studies have demonstrated an association of osteopenia/osteoporosis with idiopathic benign paroxysmal positional vertigo (BPPV). Since vitamin D takes part in the regulation of calcium and phosphorus found in the body and plays an important role in maintaining proper bone structure, decreased bone mineral density in patients with BPPV may be related to decreased serum vitamin D. We measured the serum levels of 25-hydroxyvitamin D in 100 patients (63 women and 37 men, mean age ± SD = 61.8 ± 11.6) with idiopathic BPPV and compared the data with those of 192 controls (101 women and 91 men, mean age ± SD = 60.3 ± 11.3) who had lived in the same community without dizziness or imbalance during the preceding year. The selection of the controls and acquisition of clinical information were done using the data from the Fourth Korean National Health and Nutrition Examination Survey, 2008. The serum level of 25-hydroxyvitamin D was lower in the patients with BPPV than in the controls (mean ± SD = 14.4 ± 8.4 versus 19.1 ± 6.8 ng/ml, p = 0.001). Furthermore, patients with BPPV showed a higher prevalence of decreased serum vitamin D (diabetes, proteinuria, regular exercise and the existence of decreased bone mineral density demonstrated that vitamin D insufficiency (10-20 ng/ml) and deficiency (<10 ng/ml) were associated with BPPV with the odds ratios of 3.8 (95 % confidence interval = 1.51-9.38, p = 0.004) and 23.0 (95 % confidence interval = 6.88-77.05, p < 0.001). Our study demonstrated an association between idiopathic BPPV and decreased serum vitamin D. Decreased serum vitamin D may be a risk factor of BPPV.

  8. Obliquely propagating dust-density waves

    International Nuclear Information System (INIS)

    Piel, A.; Arp, O.; Klindworth, M.; Melzer, A.

    2008-01-01

    Self-excited dust-density waves are experimentally studied in a dusty plasma under microgravity. Two types of waves are observed: a mode inside the dust volume propagating in the direction of the ion flow and another mode propagating obliquely at the boundary between the dusty plasma and the space charge sheath. The dominance of oblique modes can be described in the frame of a fluid model. It is shown that the results fom the fluid model agree remarkably well with a kinetic electrostatic model of Rosenberg [J. Vac. Sci. Technol. A 14, 631 (1996)]. In the experiment, the instability is quenched by increasing the gas pressure or decreasing the dust density. The critical pressure and dust density are well described by the models

  9. Low-memory iterative density fitting.

    Science.gov (United States)

    Grajciar, Lukáš

    2015-07-30

    A new low-memory modification of the density fitting approximation based on a combination of a continuous fast multipole method (CFMM) and a preconditioned conjugate gradient solver is presented. Iterative conjugate gradient solver uses preconditioners formed from blocks of the Coulomb metric matrix that decrease the number of iterations needed for convergence by up to one order of magnitude. The matrix-vector products needed within the iterative algorithm are calculated using CFMM, which evaluates them with the linear scaling memory requirements only. Compared with the standard density fitting implementation, up to 15-fold reduction of the memory requirements is achieved for the most efficient preconditioner at a cost of only 25% increase in computational time. The potential of the method is demonstrated by performing density functional theory calculations for zeolite fragment with 2592 atoms and 121,248 auxiliary basis functions on a single 12-core CPU workstation. © 2015 Wiley Periodicals, Inc.

  10. Effect of current density on the anodization of zircaloy-2

    International Nuclear Information System (INIS)

    Bhaskar Reddy, P.; Panasa Reddy, A.

    2005-01-01

    The effect of current density on the kinetics of anodization of Zircaloy-2 in 0.1 M potassium tartarate have been studied at various constant current densities ranging from 2 to 10 mA.cm -2 and at room temperature to investigate the exponential dependence of ionic current density on the field across the oxide. The rate of anodic film formation (dV/dt), the current efficiency the differential field of formation (F) and the ionic current density (i i ) were calculated. It was found that all these parameters were increased with increase of current density. The induction period was decreased with the increase of current density. It was also found that the plot of log (ionic current density) vs differential field gave fairly a linear relationship. The kinetic parameters, half jump distance (a) and height of the energy barrier (W) were calculated. (author)

  11. Improved GAMMA 10 tandem mirror confinement in high density plasma

    International Nuclear Information System (INIS)

    Yatsu, K.; Cho, T.; Higaki, H.; Hirata, M.; Hojo, H.; Ichimura, M.; Ishii, K.; Ishimoto, Y.; Itakura, A.; Katanuma, I.; Kohagura, J.; Minami, R.; Nakashima, Y.; Numakura, T.; Saito, T.; Saosaki, S.; Takemura, Y.; Tatematsu, Y.; Yoshida, M.; Yoshikawa, M.

    2003-01-01

    GAMMA 10 experiments have advanced in high density experiments after the last IAEA fusion energy conference in 2000 where we reported the production of the high density plasma through use of ion cyclotron range of frequency heating at a high harmonic frequency and neutral beam injection in the anchor cells. However, the diamagnetic signal of the plasma decreased when electron cyclotron resonance heating was applied for the potential formation. Recently a high density plasma has been obtained without degradation of the diamagnetic signal and with much improved reproducibility than before. The high density plasma was attained through adjustment of the spacing of the conducting plates installed in the anchor transition regions. The potential confinement of the plasma has been extensively studied. Dependences of the ion confinement time, ion-energy confinement time and plasma confining potential on plasma density were obtained for the first time in the high density region up to a density of 4x10 18 m -3 . (author)

  12. Density Distribution Sunflower Plots

    Directory of Open Access Journals (Sweden)

    William D. Dupont

    2003-01-01

    Full Text Available Density distribution sunflower plots are used to display high-density bivariate data. They are useful for data where a conventional scatter plot is difficult to read due to overstriking of the plot symbol. The x-y plane is subdivided into a lattice of regular hexagonal bins of width w specified by the user. The user also specifies the values of l, d, and k that affect the plot as follows. Individual observations are plotted when there are less than l observations per bin as in a conventional scatter plot. Each bin with from l to d observations contains a light sunflower. Other bins contain a dark sunflower. In a light sunflower each petal represents one observation. In a dark sunflower, each petal represents k observations. (A dark sunflower with p petals represents between /2-pk k and /2+pk k observations. The user can control the sizes and colors of the sunflowers. By selecting appropriate colors and sizes for the light and dark sunflowers, plots can be obtained that give both the overall sense of the data density distribution as well as the number of data points in any given region. The use of this graphic is illustrated with data from the Framingham Heart Study. A documented Stata program, called sunflower, is available to draw these graphs. It can be downloaded from the Statistical Software Components archive at http://ideas.repec.org/c/boc/bocode/s430201.html . (Journal of Statistical Software 2003; 8 (3: 1-5. Posted at http://www.jstatsoft.org/index.php?vol=8 .

  13. Air shower density spectrum

    International Nuclear Information System (INIS)

    Porter, M.R.; Foster, J.M.; Hodson, A.L.; Hazen, W.E.; Hendel, A.Z.; Bull, R.M.

    1982-01-01

    Measurements of the differential local density spectrum have been made using a 1 m 2 discharge chamber mounted in the Leeds discharge chamber array. The results are fitted to a power law of the form h(δ)dδ = kδsup(-ν)dδ, where ν=2.47+-0.04; k=0.21 s - 1 , for 7 m - 2 - 2 ; ν=2.90+-0.22; k=2.18 s - 1 , for δ > 200 m - 2 . Details of the measurement techniques are given with particular reference to the treatment of closely-spaced discharges. A comparison of these results with previous experiments using different techniques is made

  14. Measurement of loose powder density

    International Nuclear Information System (INIS)

    Akhtar, S.; Ali, A.; Haider, A.; Farooque, M.

    2011-01-01

    Powder metallurgy is a conventional technique for making engineering articles from powders. Main objective is to produce final products with the highest possible uniform density, which depends on the initial loose powder characteristics. Producing, handling, characterizing and compacting materials in loose powder form are part of the manufacturing processes. Density of loose metallic or ceramic powder is an important parameter for die design. Loose powder density is required for calculating the exact mass of powder to fill the die cavity for producing intended green density of the powder compact. To fulfill this requirement of powder metallurgical processing, a loose powder density meter as per ASTM standards is designed and fabricated for measurement of density. The density of free flowing metallic powders can be determined using Hall flow meter funnel and density cup of 25 cm/sup 3/ volume. Density of metal powders like cobalt, manganese, spherical bronze and pure iron is measured and results are obtained with 99.9% accuracy. (author)

  15. Distraction decreases prefrontal oxygenation: A NIRS study.

    Science.gov (United States)

    Ozawa, Sachiyo; Hiraki, Kazuo

    2017-04-01

    When near-infrared spectroscopy (NIRS) is used to measure emotion-related cerebral blood flow (CBF) changes in the prefrontal cortex regions, the functional distinction of CBF changes is often difficult because NIRS is unable to measure neural activity in deeper brain regions that play major roles in emotional processing. The CBF changes could represent cognitive control of emotion and emotional responses to emotional materials. Supposing that emotion-related CBF changes in the prefrontal cortex regions during distraction are emotional responses, we examined whether oxygenated hemoglobin (oxyHb) decreases. Attention-demanding tasks cause blood flow decreases, and we thus compared the effects of visually paced tapping with different tempos, on distraction. The results showed that the oxyHb level induced by emotional stimulation decreased with fast-tempo tapping significantly more than slow-tempo tapping in ventral medial prefrontal cortex regions. Moreover, a Global-Local task following tapping showed significantly greater local-minus-global response time (RT) difference scores in the fast- and mid-tempo condition compared with those in the slow-tempo, suggesting an increased attentional focus, and decreased negative emotion. The overall findings indicate that oxyHb changes in a relatively long distraction task, as measured by NIRS, are associated with emotional responses, and oxyHb can be decreased by successfully performing attention-demanding distraction tasks. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. Gluon density in nuclei

    International Nuclear Information System (INIS)

    Ayala, A.L.

    1996-01-01

    In this talk we present our detailed study (theory and numbers) on the shadowing corrections to the gluon structure functions for nuclei. Starting from rather controversial information on the nucleon structure function which is originated by the recent HERA data, we develop the Glauber approach for the gluon density in a nucleus based on Mueller formula and estimate the value of the shadowing corrections in this case. Then we calculate the first corrections to the Glauber approach and show that these corrections are big. Based on this practical observation we suggest the new evolution equation which takes into account the shadowing corrections and solve it. We hope to convince you that the new evolution equation gives a good theoretical tool to treat the shadowing corrections for the gluons density in a nucleus and, therefore, it is able to provide the theoretically reliable initial conditions for the time evolution of the nucleus-nucleus cascade. The initial conditions should be fixed both theoretically and phenomenologically before to attack such complicated problems as the mixture of hard and soft processes in nucleus-nucleus interactions at high energy or the theoretically reliable approach to hadron or/and parton cascades for high energy nucleus-nucleus interaction. 35 refs., 24 figs., 1 tab

  17. On radiative density limits in stellarators

    International Nuclear Information System (INIS)

    Wobig, H.

    2001-01-01

    Density limits in stellarators are caused mainly by enhanced impurity radiation leading to a collapse of the temperature. A simple model can be established, which computes the temperature in the plasma with a fixed heating profile and a temperature-dependent radiation profile. If the temperature-dependent radiation function has one or several extrema, multiple solutions of the transport equation exist and radiative collapse occurs when the high temperature branch merges with the unstable temperature branch. At this bifurcation point the temperature decreases to a stable low temperature solution. The bifurcation point is a function of the heating power and the plasma density. Thus a density limit can be defined as the point where bifurcation occurs. It is shown that bifurcation and sudden temperature collapse does not occur below a power threshold. Anomalous thermal conductivity and the details of the impurity radiation, which in the present model is assumed to be in corona equilibrium, determine the scaling of the density limit. A model of the anomalous transport is developed, which leads to Gyro-Bohm scaling of the confinement time. The density limit based on this transport model is close to experimental findings in Wendelstein 7-AS. (author)

  18. Bone density in apheresis donors and whole blood donors

    NARCIS (Netherlands)

    Boot, C.L.; Luken, J.S.; van den Burg, P.J.M.; de Kort, W.L.A.M.; Koopman, M.M.W.; Vrielink, H.; van Schoor, N.M.; den Heijer, M.; Lips, P.

    2015-01-01

    Apheresis donation using citrate causes acute decrease in serum calcium and increase in serum parathyroid hormone. Long-term consequences, such as decrease in bone mineral density (BMD), are not known. In this study, we compared the BMD of 20 postmenopausal apheresis donors (mean donation number 115

  19. Density of Ni-Cr Alloy in the Mushy State

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The density of Ni-Cr alloy in the mushy state has been measured using the modified sessile drop method. The density of Ni-Cr alloy in the mushy state was found to decrease with increasing temperature and Cr concentration in alloy.The molar volume of Ni-Cr alloy in the mushy state therefore increases with increasing the Cr concentration in alloy.The ratio of the difference of density divided by the temperature difference between liquidus and solidus temperatures decreases with increasing Cr concentration. The density of the alloy increased with the precipitation of a solid phase in alloy during the solidification process. The temperature dependence of the density of alloy in the mushy state was not linear but biquadratic.

  20. Cigarette smoke decreases mitochondrial porin expression and steroidogenesis

    International Nuclear Information System (INIS)

    Bose, Mahuya; Whittal, Randy M.; Gairola, C. Gary; Bose, Himangshu S.

    2008-01-01

    Steroidogenic acute regulatory protein (StAR) facilitates the movement of cholesterol from the outer to inner mitochondrial membrane for steroidogenesis. Here, we investigated the effect of cigarette smoke (CS) on steroidogenesis using adrenal mitochondria isolated from mice chronically exposed to CS. Steroidogenesis was decreased approximately 78% in CS-exposed mitochondria, as measured by synthesis of the steroid hormone precursor pregnenolone. This effect was accompanied by decreased mitochondrial import of 35 S-StAR. Further characterization of the imported 35 S-StAR by native gradient PAGE revealed the presence of a high molecular weight complex in both control and CS-exposed groups. Following density gradient fractionation of 35 S-StAR that had been extracted from control mitochondria, precursor StAR could be found in fractions 2-6 and smaller-sized StAR complexes in fractions 6-13. In the CS-exposed group, the appearance of precursor shifted from fraction 1-6 and the smaller complexes in fractions 6-9 disappeared. Mass spectrometric analysis revealed that the 35 S-StAR-associated protein complex was composed of several resident matrix proteins as well as the OMM resident, VDAC. VDAC expression was greatly reduced by CS, and blockage of VDAC with Koenig's polyanion decreased pregnenolone synthesis in isolated mitochondria. Taken together, these results suggest that VDAC may participate in steroidogenesis by promoting StAR interaction with the OMM and that CS may inhibit steroidogenesis by reducing VDAC-StAR interactions

  1. Anomalous evolution of Ar metastable density with electron density in high density Ar discharge

    International Nuclear Information System (INIS)

    Park, Min; Chang, Hong-Young; You, Shin-Jae; Kim, Jung-Hyung; Shin, Yong-Hyeon

    2011-01-01

    Recently, an anomalous evolution of argon metastable density with plasma discharge power (electron density) was reported [A. M. Daltrini, S. A. Moshkalev, T. J. Morgan, R. B. Piejak, and W. G. Graham, Appl. Phys. Lett. 92, 061504 (2008)]. Although the importance of the metastable atom and its density has been reported in a lot of literature, however, a basic physics behind the anomalous evolution of metastable density has not been clearly understood yet. In this study, we investigated a simple global model to elucidate the underlying physics of the anomalous evolution of argon metastable density with the electron density. On the basis of the proposed simple model, we reproduced the anomalous evolution of the metastable density and disclosed the detailed physics for the anomalous result. Drastic changes of dominant mechanisms for the population and depopulation processes of Ar metastable atoms with electron density, which take place even in relatively low electron density regime, is the clue to understand the result.

  2. Aggregate Unemployment Decreases Individual Returns to Education

    Science.gov (United States)

    Ammermueller, Andreas; Kuckulenz, Anja; Zwick, Thomas

    2009-01-01

    Aggregate unemployment may affect individual returns to education through qualification-specific responses in participation and wage bargaining. This paper shows that an increase in regional unemployment by 1% decreases returns to education by 0.005 percentage points. This implies that higher skilled employees are better sheltered from labour…

  3. Density-Functional formalism

    International Nuclear Information System (INIS)

    Szasz, L.; Berrios-Pagan, I.; McGinn, G.

    1975-01-01

    A new Density-Functional formula is constructed for atoms. The kinetic energy of the electron is divided into two parts: the kinetic self-energy and the orthogonalization energy. Calculations were made for the total energies of neutral atoms, positive ions and for the He isoelectronic series. For neutral atoms the results match the Hartree-Fock energies within 1% for atoms with N 36 the results generally match the HF energies within 0.1%. For positive ions the results are fair; for the molecular applications a simplified model is developed in which the kinetic energy consists of the Weizsaecker term plus the Fermi energy reduced by a continuous function. (orig.) [de

  4. Density functional theory

    International Nuclear Information System (INIS)

    Freyss, M.

    2015-01-01

    This chapter gives an introduction to first-principles electronic structure calculations based on the density functional theory (DFT). Electronic structure calculations have a crucial importance in the multi-scale modelling scheme of materials: not only do they enable one to accurately determine physical and chemical properties of materials, they also provide data for the adjustment of parameters (or potentials) in higher-scale methods such as classical molecular dynamics, kinetic Monte Carlo, cluster dynamics, etc. Most of the properties of a solid depend on the behaviour of its electrons, and in order to model or predict them it is necessary to have an accurate method to compute the electronic structure. DFT is based on quantum theory and does not make use of any adjustable or empirical parameter: the only input data are the atomic number of the constituent atoms and some initial structural information. The complicated many-body problem of interacting electrons is replaced by an equivalent single electron problem, in which each electron is moving in an effective potential. DFT has been successfully applied to the determination of structural or dynamical properties (lattice structure, charge density, magnetisation, phonon spectra, etc.) of a wide variety of solids. Its efficiency was acknowledged by the attribution of the Nobel Prize in Chemistry in 1998 to one of its authors, Walter Kohn. A particular attention is given in this chapter to the ability of DFT to model the physical properties of nuclear materials such as actinide compounds. The specificities of the 5f electrons of actinides will be presented, i.e., their more or less high degree of localisation around the nuclei and correlations. The limitations of the DFT to treat the strong 5f correlations are one of the main issues for the DFT modelling of nuclear fuels. Various methods that exist to better treat strongly correlated materials will finally be presented. (author)

  5. Hormonal Determinants of Mammographic Density

    National Research Council Canada - National Science Library

    Simpson, Jennifer K; Modugno, Francemary; Weissfeld, Joel L; Kuller, Lewis; Vogel, Victor; Constantino, Joseph P

    2005-01-01

    .... However, not all women on HRT will experience an increase in breast density. We propose a novel hypothesis to explain in part the individual variability in breast density seen among women on HRT...

  6. Characterising root density of peach trees in a semi-arid Chernozem to increase plant density

    Science.gov (United States)

    Paltineanu, Cristian; Septar, Leinar; Gavat, Corina; Chitu, Emil; Oprita, Alexandru; Moale, Cristina; Calciu, Irina; Vizitiu, Olga; Lamureanu, Gheorghe

    2016-01-01

    The available information on root system in fully mature peach orchards in semi-arid regions is insufficient. This paper presents a study on the root system density in an irrigated peach orchard from Dobrogea, Romania, using the trench technique. The old orchard has clean cultivation in inter-row and in-row. The objectives of the study were to: test the hypothesis that the roots of fully mature peach trees occupy the whole soil volume; find out if root repulsive effect of adjacent plants occurred for the rootstocks and soil conditions; find relationships between root system and soil properties and analyse soil state trend. Some soil physical properties were significantly deteriorated in inter-row versus in-row, mainly due to soil compaction induced by technological traffic. Density of total roots was higher in-row than inter-row, but the differences were not significant. Root density decreased more intensely with soil depth than with distance from tree trunks. Root density correlated with some soil properties. No repulsive effect of the roots of adjacent peach trees was noted. The decrease of root density with distance from trunk can be used in optimising tree arrangement. The conclusions could also be used in countries with similar growth conditions.

  7. On lower hybrid wave scattering by plasma density fluctuations

    International Nuclear Information System (INIS)

    Petrzilka, V.

    1988-01-01

    The scattering of lower hybrid waves on plasma density fluctuations in a thin turbulent layer at the plasma periphery is studied numerically. The lower hybrid waves are supposed to be radiated by a four-waveguide grill used on the CASTOR tokamak. A great number of calculated scattered wave spectra show that the scattered spectrum shifts to larger values of the parallel-to-magnetic-field component of the wave vector (to slower waves) with increasing central plasma density and with the decreasing safety factor at the boundary. As known, this shift of the wave spectra results in a decrease in current drive efficiency. The current drive efficiency will hence decrease with growing plasma density and with decreasing safety factor. (J.U.). 2 figs., 4 refs

  8. Density limit in ASDEX discharges with peaked density profiles

    International Nuclear Information System (INIS)

    Staebler, A.; Niedermeyer, H.; Loch, R.; Mertens, V.; Mueller, E.R.; Soeldner, F.X.; Wagner, F.

    1989-01-01

    Results concerning the density limit in OH and NI-heated ASDEX discharges with the usually observed broad density profiles have been reported earlier: In ohmic discharges with high q a (q-cylindrical is used throughout this paper) the Murakami parameter (n e R/B t ) is a good scaling parameter. At the high densities edge cooling is observed causing the plasma to shrink until an m=2-instability terminates the discharge. When approaching q a =2 the density limit is no longer proportional to I p ; a minimum exists in n e,max (q a ) at q a ∼2.15. With NI-heating the density limit increases less than proportional to the heating power; the behaviour during the pre-disruptive phase is rather similar to the one of OH discharges. There are specific operating regimes on ASDEX leading to discharges with strongly peaked density profiles: the improved ohmic confinement regime, counter neutral injection, and multipellet injection. These regimes are characterized by enhanced energy and particle confinement. The operational limit in density for these discharges is, therefore, of great interest having furthermore in mind that high central densities are favourable in achieving high fusion yields. In addition, further insight into the mechanisms of the density limit observed in tokamaks may be obtained by comparing plasmas with rather different density profiles at their maximum attainable densities. 7 refs., 2 figs

  9. Edge plasma density convection during ICRH on Tore Supra

    International Nuclear Information System (INIS)

    Becoulet, M.; Colas, L.; Gunn, J.; Ghendrih, Ph.; Becoulet, A.; Pecoul, S.; Heuraux, S.

    2001-11-01

    The 2D edge plasma density distribution around ion cyclotron resonance heating (ICRH) antennae is studied experimentally and numerically in the tokamak Tore Supra (TS). A local density decrease in front of the loaded ICRH antenna ('pump-out' effect) is demonstrated by Langmuir probe measurements in a low recycling regime. An up-down asymmetry in the heat-flux and in the antenna erosion is also observed, and is associated with poloidal variations of the local density. These density redistributions are ascribed to an ExB convection process linked with RF-sheaths. To assess this interpretation, the 2D transport code CELLS was developed for modeling the density distribution near an antenna. The code takes into account perpendicular diffusion, parallel transport and convection in RF-sheath-driven potentials given by the 3D-antenna code ICANT. The strong density differences obtained in simulations reproduce up-down asymmetries of the heat fluxes. (authors)

  10. Edge plasma density convection during ICRH on Tore Supra

    Energy Technology Data Exchange (ETDEWEB)

    Becoulet, M.; Colas, L.; Gunn, J.; Ghendrih, Ph.; Becoulet, A. [Association Euratom-CEA Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Recherches sur la Fusion Controlee; Pecoul, S.; Heuraux, S. [Nancy-1 Univ., 54 (France). Lab. de Physique des Milieux Ionises

    2001-11-01

    The 2D edge plasma density distribution around ion cyclotron resonance heating (ICRH) antennae is studied experimentally and numerically in the tokamak Tore Supra (TS). A local density decrease in front of the loaded ICRH antenna ('pump-out' effect) is demonstrated by Langmuir probe measurements in a low recycling regime. An up-down asymmetry in the heat-flux and in the antenna erosion is also observed, and is associated with poloidal variations of the local density. These density redistributions are ascribed to an ExB convection process linked with RF-sheaths. To assess this interpretation, the 2D transport code CELLS was developed for modeling the density distribution near an antenna. The code takes into account perpendicular diffusion, parallel transport and convection in RF-sheath-driven potentials given by the 3D-antenna code ICANT. The strong density differences obtained in simulations reproduce up-down asymmetries of the heat fluxes. (authors)

  11. Did liberalising bar hours decrease traffic accidents?

    Science.gov (United States)

    Green, Colin P; Heywood, John S; Navarro, Maria

    2014-05-01

    Legal bar closing times in England and Wales have historically been early and uniform. Recent legislation liberalised closing times with the object of reducing social problems thought associated with drinking to "beat the clock." Indeed, using both difference in difference and synthetic control approaches we show that one consequence of this liberalisation was a decrease in traffic accidents. This decrease is heavily concentrated among younger drivers. Moreover, we provide evidence that the effect was most pronounced in the hours of the week directly affected by the liberalisation: late nights and early mornings on weekends. This evidence survives a series of robustness checks and suggests at least one socially positive consequence of extending bar hours. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. Decreased decorin expression in the tumor microenvironment

    International Nuclear Information System (INIS)

    Bozoky, Benedek; Savchenko, Andrii; Guven, Hayrettin; Ponten, Fredrik; Klein, George; Szekely, Laszlo

    2014-01-01

    Decorin is a small leucine-rich proteoglycan, synthesized and deposited by fibroblasts in the stroma where it binds to collagen I. It sequesters several growth factors and antagonizes numerous members of the receptor tyrosine kinase family. In experimental murine systems, it acted as a potent tumor suppressor. Examining the Human Protein Atlas online database of immunostained tissue samples we have surveyed decorin expression in silico in several different tumor types, comparing them with corresponding normal tissues. We found that decorin is abundantly secreted and deposited in normal connective tissue but its expression is consistently decreased in the tumor microenvironment. We developed a software to quantitate the difference in expression. The presence of two closely related proteoglycans in the newly formed tumor stroma indicated that the decreased decorin expression was not caused by the delay in proteoglycan deposition in the newly formed connective tissue surrounding the tumor

  13. Calming Meditation Increases Altruism, Decreases Parochialism

    OpenAIRE

    Frost, Karl

    2017-01-01

    It has been proposed that cultivating calm will increase altruism and decrease parochialism, where altruism is defined as self-sacrifice in support of others, regardless of group affiliation or identity, and parochialism is defined as prosocial self-sacrifice restricted to fellow members of a group. Such could be the case with a calming meditation practice. An alternate hypothesis, coming from the study of ritual, proposes that shared practices lead to bonding, increasing parochialism, but no...

  14. INVENTORY DECISIONS WITH DECREASING PURCHASING COSTS

    OpenAIRE

    XIANGPEI HU; HUIMIN WANG; YUNZENG WANG

    2012-01-01

    Costs of many items drop systematically throughout their life-cycles, due to advances in technology and competition. Motivated by the management of service parts for some high-tech products, this paper studies inventory decisions for such items. In a periodic review setting with stochastic demand, we model the purchasing costs of successive periods as a stochastic and decreasing sequence. Unit selling price of the item is determined as some mark-up of the purchasing cost and, hence, will chan...

  15. Decreased prefrontal cortical dopamine transmission in alcoholism.

    Science.gov (United States)

    Narendran, Rajesh; Mason, Neale Scott; Paris, Jennifer; Himes, Michael L; Douaihy, Antoine B; Frankle, W Gordon

    2014-08-01

    Basic studies have demonstrated that optimal levels of prefrontal cortical dopamine are critical to various executive functions such as working memory, attention, inhibitory control, and risk/reward decisions, all of which are impaired in addictive disorders such as alcoholism. Based on this and imaging studies of alcoholism that have demonstrated less dopamine in the striatum, the authors hypothesized decreased dopamine transmission in the prefrontal cortex in persons with alcohol dependence. To test this hypothesis, amphetamine and [11C]FLB 457 positron emission tomography were used to measure cortical dopamine transmission in 21 recently abstinent persons with alcohol dependence and 21 matched healthy comparison subjects. [11C]FLB 457 binding potential, specific compared to nondisplaceable uptake (BPND), was measured in subjects with kinetic analysis using the arterial input function both before and after 0.5 mg kg-1 of d-amphetamine. Amphetamine-induced displacement of [11C]FLB 457 binding potential (ΔBPND) was significantly smaller in the cortical regions in the alcohol-dependent group compared with the healthy comparison group. Cortical regions that demonstrated lower dopamine transmission in the alcohol-dependent group included the dorsolateral prefrontal cortex, medial prefrontal cortex, orbital frontal cortex, temporal cortex, and medial temporal lobe. The results of this study, for the first time, unambiguously demonstrate decreased dopamine transmission in the cortex in alcoholism. Further research is necessary to understand the clinical relevance of decreased cortical dopamine as to whether it is related to impaired executive function, relapse, and outcome in alcoholism.

  16. Smoothing densities under shape constraints

    OpenAIRE

    Davies, Paul Laurie; Meise, Monika

    2009-01-01

    In Davies and Kovac (2004) the taut string method was proposed for calculating a density which is consistent with the data and has the minimum number of peaks. The main disadvantage of the taut string density is that it is piecewise constant. In this paper a procedure is presented which gives a smoother density by minimizing the total variation of a derivative of the density subject to the number, positions and heights of the local extreme values obtained from the taut string density. 2...

  17. High-Power-Density, High-Energy-Density Fluorinated Graphene for Primary Lithium Batteries

    Directory of Open Access Journals (Sweden)

    Guiming Zhong

    2018-03-01

    Full Text Available Li/CFx is one of the highest-energy-density primary batteries; however, poor rate capability hinders its practical applications in high-power devices. Here we report a preparation of fluorinated graphene (GFx with superior performance through a direct gas fluorination method. We find that the so-called “semi-ionic” C-F bond content in all C-F bonds presents a more critical impact on rate performance of the GFx in comparison with sp2 C content in the GFx, morphology, structure, and specific surface area of the materials. The rate capability remains excellent before the semi-ionic C-F bond proportion in the GFx decreases. Thus, by optimizing semi-ionic C-F content in our GFx, we obtain the optimal x of 0.8, with which the GF0.8 exhibits a very high energy density of 1,073 Wh kg−1 and an excellent power density of 21,460 W kg−1 at a high current density of 10 A g−1. More importantly, our approach opens a new avenue to obtain fluorinated carbon with high energy densities without compromising high power densities.

  18. Can complexity decrease in congestive heart failure?

    Science.gov (United States)

    Mukherjee, Sayan; Palit, Sanjay Kumar; Banerjee, Santo; Ariffin, M. R. K.; Rondoni, Lamberto; Bhattacharya, D. K.

    2015-12-01

    The complexity of a signal can be measured by the Recurrence period density entropy (RPDE) from the reconstructed phase space. We have chosen a window based RPDE method for the classification of signals, as RPDE is an average entropic measure of the whole phase space. We have observed the changes in the complexity in cardiac signals of normal healthy person (NHP) and congestive heart failure patients (CHFP). The results show that the cardiac dynamics of a healthy subject is more complex and random compare to the same for a heart failure patient, whose dynamics is more deterministic. We have constructed a general threshold to distinguish the border line between a healthy and a congestive heart failure dynamics. The results may be useful for wide range for physiological and biomedical analysis.

  19. High density hydrogen research

    International Nuclear Information System (INIS)

    Hawke, R.S.

    1977-01-01

    The interest in the properties of very dense hydrogen is prompted by its abundance in Saturn and Jupiter and its importance in laser fusion studies. Furthermore, it has been proposed that the metallic form of hydrogen may be a superconductor at relatively high temperatures and/or exist in a metastable phase at ambient pressure. For ten years or more, laboratories have been developing the techniques to study hydrogen in the megabar region (1 megabar = 100 GPa). Three major approaches to study dense hydrogen experimentally have been used, static presses, shockwave compression, and magnetic compression. Static tchniques have crossed the megabar threshold in stiff materials but have not yet been convincingly successful in very compressible hydrogen. Single and double shockwave techniques have improved the precision of the pressure, volume, temperature Equation of State (EOS) of molecular hydrogen (deuterium) up to near 1 Mbar. Multiple shockwave and magnetic techniques have compressed hydrogen to several megabars and densities in the range of the metallic phase. The net result is that hydrogen becomes conducting at a pressure between 2 and 4 megabars. Hence, the possibility of making a significant amount of hydrogen into a metal in a static press remains a formidable challenge. The success of such experiments will hopefully answer the questions about hydrogen's metallic vs. conducting molecular phase, superconductivity, and metastability. 4 figures, 15 references

  20. Influência da população de plantas sob o crescimento e produção orgânica de alface no Sertão paraibano

    Directory of Open Access Journals (Sweden)

    Ivando Comandante de Macedo Silva

    2016-04-01

    Full Text Available O grau de interferência entre plantas em função da densidade é um dos fatores que afeta a quantidade e qualidade das mesmas, pois quanto maior a densidade de plantas, mais elevada será a concorrência pelos recursos do ambiente. O presente trabalho objetiva avaliar o efeito da competição intraespecífica dos diferentes espaçamentos sobre o crescimento e produção da alface Cristina. O experimento foi conduzido em área experimental do Centro de Ciências e Tecnologia Agroalimentar da Universidade Federal de Campina Grande, em Pombal, PB. O trabalho foi realizado em blocos casualisados, compostos por quatro espaçamentos: 0,25 x 0,30; 0,25 x 0,25; 0,20 x 0,25 e 0,20 x 0,20 m, totalizando um número de: 100.000; 120.000; 150.000 e 187.000 plantas por hectare, respectivamente, com cinco repetições. Tendo como base a recomendação da adubação do estado do Pernambuco, foi aplicada a dose de 130 Kg ha-1 doN indicado para alface tendo como fonte o esterco caprino. A adubação orgânica foi incorporada 10 dias antes do transplantio na camada de 0-15 cm do canteiro. A irrigação foi realizada por microaspersão e a colheita efetuada 30 dias após o transplantio das mudas. Foram avaliados os seguintes parâmetros: altura da parte aérea, diâmetro da cabeça, número de folhas, volume de raiz, massa fresca da parte aérea e da raiz, massa fresca total, massa seca da parte aérea e da raiz, e massa seca total. Os dados foram submetidos a analise de Regressão Polinomial. Plantas de alface cv. Cristina quando cultivadas em maiores adensamentos mantiveram maior produção.Influence of plant population in the growth and production organic of lettuce in the backlands of ParaibaAbstract: The degree of interference between the plants versus density is a factor that affects the quantity and quality thereof, because the higher the plant density, greater competition for environmental resources. This study aims to evaluate the effect of intraspecific

  1. Dual effects of pedestrian density on emergency evacuation

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Yi, E-mail: yima23-c@my.cityu.edu.hk [School of Transportation and Logistics, Southwest Jiaotong University, Chengdu (China); Department of Architecture and Civil Engineering, City University of Hong Kong, Kowloon (Hong Kong); Lee, Eric Wai Ming; Yuen, Richard Kwok Kit [Department of Architecture and Civil Engineering, City University of Hong Kong, Kowloon (Hong Kong)

    2017-02-05

    This paper investigates the effect of the pedestrian density in building on the evacuation dynamic with simulation method. In the simulations, both the visibility in building and the exit limit of building are taken into account. The simulation results show that the effect of the pedestrian density in building on the evacuation dynamics is dual. On the one hand, when the visibility in building is very large, the increased pedestrian density plays a negative effect. On the other hand, when the visibility in building is very small, the increased pedestrian density can play a positive effect. The simulation results also show that when both the exit width and visibility are very small, the varying of evacuation time with regard to the pedestrian density is non-monotonous and presents a U-shaped tendency. That is, in this case, too large or too small pedestrian density in building is disadvantageous to the evacuation process. Our findings provide a new insight about the effect of the pedestrian density in building on the evacuation dynamic. - Highlights: • Pedestrian density inside buildings has dual effects on evacuation. • Increased pedestrian density has a negative effect in cases of increased visibility. • Increased pedestrian density has a positive effect in cases of decreased visibility.

  2. Dual effects of pedestrian density on emergency evacuation

    International Nuclear Information System (INIS)

    Ma, Yi; Lee, Eric Wai Ming; Yuen, Richard Kwok Kit

    2017-01-01

    This paper investigates the effect of the pedestrian density in building on the evacuation dynamic with simulation method. In the simulations, both the visibility in building and the exit limit of building are taken into account. The simulation results show that the effect of the pedestrian density in building on the evacuation dynamics is dual. On the one hand, when the visibility in building is very large, the increased pedestrian density plays a negative effect. On the other hand, when the visibility in building is very small, the increased pedestrian density can play a positive effect. The simulation results also show that when both the exit width and visibility are very small, the varying of evacuation time with regard to the pedestrian density is non-monotonous and presents a U-shaped tendency. That is, in this case, too large or too small pedestrian density in building is disadvantageous to the evacuation process. Our findings provide a new insight about the effect of the pedestrian density in building on the evacuation dynamic. - Highlights: • Pedestrian density inside buildings has dual effects on evacuation. • Increased pedestrian density has a negative effect in cases of increased visibility. • Increased pedestrian density has a positive effect in cases of decreased visibility.

  3. Music decreases aortic stiffness and wave reflections.

    Science.gov (United States)

    Vlachopoulos, Charalambos; Aggelakas, Angelos; Ioakeimidis, Nikolaos; Xaplanteris, Panagiotis; Terentes-Printzios, Dimitrios; Abdelrasoul, Mahmoud; Lazaros, George; Tousoulis, Dimitris

    2015-05-01

    Music has been related to cardiovascular health and used as adjunct therapy in patients with cardiovascular disease. Aortic stiffness and wave reflections are predictors of cardiovascular risk. We investigated the short-term effect of classical and rock music on arterial stiffness and wave reflections. Twenty healthy individuals (22.5±2.5 years) were studied on three different occasions and listened to a 30-min music track compilation (classical, rock, or no music for the sham procedure). Both classical and rock music resulted in a decrease of carotid-femoral pulse wave velocity (PWV) immediately after the end of music listening (all pclassical or rock music in a more sustained way (nadir by 6.0% and 5.8%, respectively, at time zero post-music listening, all pmusic preference was taken into consideration, both classical and rock music had a more potent effect on PWV in classical aficionados (by 0.20 m/s, p=0.003 and 0.13 m/s, p=0.015, respectively), whereas there was no effect in rock aficionados (all p=NS). Regarding wave reflections, classical music led to a more potent response in classical aficionados (AIx decrease by 9.45%), whereas rock led to a more potent response to rock aficionados (by 10.7%, all pMusic, both classical and rock, decreases aortic stiffness and wave reflections. Effect on aortic stiffness lasts for as long as music is listened to, while classical music has a sustained effect on wave reflections. These findings may have important implications, extending the spectrum of lifestyle modifications that can ameliorate arterial function. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  4. SPP will decrease price of transport

    International Nuclear Information System (INIS)

    Janoska, J.

    2003-01-01

    Starting next year gas utility Slovensky plynarensky priemysel, a.s., Bratislava (SPP) will decrease the fees for transport of gas to its client from third parties. This decision should have a positive effect mainly on large industrial customers. The fact that SPP decided not to apply the approved ruling to its full extent was the result of negotiations with the regulator and the Ministry of Economy. SPP is not afraid it might lose customers. This decision only gives them a competitive advantage. (Author)

  5. Decreasing Human Trafficking through Sex Work Decriminalization.

    Science.gov (United States)

    Albright, Erin; D'Adamo, Kate

    2017-01-01

    In order to decrease human trafficking, health care workers should support the full decriminalization of prostitution. Similar to trafficking in other forms of labor, preventing trafficking in the sex trade requires addressing the different forms of marginalization that create vulnerable communities. By removing punitive laws that prevent reporting of exploitation and abuse, decriminalization allows sex workers to work more safely, thereby reducing marginalization and vulnerability. Decriminalization can also help destigmatize sex work and help resist political, social, and cultural marginalization of sex workers. © 2017 American Medical Association. All Rights Reserved.

  6. Methodology of decreasing software complexity using ontology

    Science.gov (United States)

    DÄ browska-Kubik, Katarzyna

    2015-09-01

    In this paper a model of web application`s source code, based on the OSD ontology (Ontology for Software Development), is proposed. This model is applied to implementation and maintenance phase of software development process through the DevOntoCreator tool [5]. The aim of this solution is decreasing software complexity of that source code, using many different maintenance techniques, like creation of documentation, elimination dead code, cloned code or bugs, which were known before [1][2]. Due to this approach saving on software maintenance costs of web applications will be possible.

  7. Density limit experiments on FTU

    International Nuclear Information System (INIS)

    Pucella, G.; Tudisco, O.; Apicella, M.L.; Apruzzese, G.; Artaserse, G.; Belli, F.; Boncagni, L.; Botrugno, A.; Buratti, P.; Calabrò, G.; Castaldo, C.; Cianfarani, C.; Cocilovo, V.; Dimatteo, L.; Esposito, B.; Frigione, D.; Gabellieri, L.; Giovannozzi, E.; Bin, W.; Granucci, G.

    2013-01-01

    One of the main problems in tokamak fusion devices concerns the capability to operate at a high plasma density, which is observed to be limited by the appearance of catastrophic events causing loss of plasma confinement. The commonly used empirical scaling law for the density limit is the Greenwald limit, predicting that the maximum achievable line-averaged density along a central chord depends only on the average plasma current density. However, the Greenwald density limit has been exceeded in tokamak experiments in the case of peaked density profiles, indicating that the edge density is the real parameter responsible for the density limit. Recently, it has been shown on the Frascati Tokamak Upgrade (FTU) that the Greenwald density limit is exceeded in gas-fuelled discharges with a high value of the edge safety factor. In order to understand this behaviour, dedicated density limit experiments were performed on FTU, in which the high density domain was explored in a wide range of values of plasma current (I p = 500–900 kA) and toroidal magnetic field (B T = 4–8 T). These experiments confirm the edge nature of the density limit, as a Greenwald-like scaling holds for the maximum achievable line-averaged density along a peripheral chord passing at r/a ≃ 4/5. On the other hand, the maximum achievable line-averaged density along a central chord does not depend on the average plasma current density and essentially depends on the toroidal magnetic field only. This behaviour is explained in terms of density profile peaking in the high density domain, with a peaking factor at the disruption depending on the edge safety factor. The possibility that the MARFE (multifaced asymmetric radiation from the edge) phenomenon is the cause of the peaking has been considered, with the MARFE believed to form a channel for the penetration of the neutral particles into deeper layers of the plasma. Finally, the magnetohydrodynamic (MHD) analysis has shown that also the central line

  8. Resolvability of regional density structure

    Science.gov (United States)

    Plonka, A.; Fichtner, A.

    2016-12-01

    Lateral density variations are the source of mass transport in the Earth at all scales, acting as drivers of convectivemotion. However, the density structure of the Earth remains largely unknown since classic seismic observables and gravityprovide only weak constraints with strong trade-offs. Current density models are therefore often based on velocity scaling,making strong assumptions on the origin of structural heterogeneities, which may not necessarily be correct. Our goal is to assessif 3D density structure may be resolvable with emerging full-waveform inversion techniques. We have previously quantified the impact of regional-scale crustal density structure on seismic waveforms with the conclusion that reasonably sized density variations within thecrust can leave a strong imprint on both travel times and amplitudes, and, while this can produce significant biases in velocity and Q estimates, the seismic waveform inversion for density may become feasible. In this study we performprincipal component analyses of sensitivity kernels for P velocity, S velocity, and density. This is intended to establish theextent to which these kernels are linearly independent, i.e. the extent to which the different parameters may be constrainedindependently. Since the density imprint we observe is not exclusively linked to travel times and amplitudes of specific phases,we consider waveform differences between complete seismograms. We test the method using a known smooth model of the crust and seismograms with clear Love and Rayleigh waves, showing that - as expected - the first principal kernel maximizes sensitivity to SH and SV velocity structure, respectively, and that the leakage between S velocity, P velocity and density parameter spaces is minimal in the chosen setup. Next, we apply the method to data from 81 events around the Iberian Penninsula, registered in total by 492 stations. The objective is to find a principal kernel which would maximize the sensitivity to density

  9. Vida em Santidade: modos de ser santo em uma comunidade messiânico-milenarista do sertão baiano (Pau de Colher, 1934-1938 - DOI: 10.5752/P.2175-5841.2010v8n18p170

    Directory of Open Access Journals (Sweden)

    Filipe Pinto Monteiro

    2010-11-01

    Full Text Available A proposta do artigo é analisar o fenômeno peculiar da honraria santoral na comunidade messiânico-milenarista de Pau de Colher (Casa Nova, sertão da Bahia, 1934-1938. A partir de um recorte histórico-cultural e teológico, a investigação será encaminhada no sentido de esclarecer a atuação de uma liderança religiosa, popular e carismática atada a modelos de santidade gestados durante o período medieval no ocidente cristão e transmigrados para o Novo Mundo após os descobrimentos. O texto apresenta documentação inédita e estabelece uma discussão - a partir de obras clássicas e outras referências garimpadas ao longo da pesquisa - em torno da manifestação de santos católicos no interior baiano na década de 30 do século XX. O movimento de Pau de Colher, através da pregação de seus líderes, instituiu um diálogo com uma tradição que remonta às origens do cristianismo; fez crer na ressurreição de personagens como São José, o Carpinteiro e Santa Maria, a Imaculada -, figuras privilegiadas em nosso estudo -; e re-atualizou um conjunto de credos e valores transmitidos pelas mãos de missionários itinerantes e de beatos errantes durante a história do Brasil, revelando um intenso hibridismo entre catolicismo popular e eclesiástico. Palavras-chave: Pau de Colher; santos; sertão; catolicismo; religiosidade popular.   Abstract The aim of this paper is to analyze the peculiar phenomenon of the honor saints in the messianic-millenarian community of Pau de Colher (Casa Nova, interior of Bahia, 1934-1938. From a cultural-historical and theological approach, the research will be directed towards clarifying the role of religious, popular and charismatic leadership tied to models of holiness gestated during the medieval period in the Christian West and transmigrated to the New World after the discoveries. The paper presents unpublished documentation and provides a discussion - from classical works and other references panned

  10. Breastfeeding Is Associated with Decreased Childhood Maltreatment.

    Science.gov (United States)

    Kremer, Kristen P; Kremer, Theodore R

    Child maltreatment has serious implications for youth outcomes, yet its associations with early parenting practices are not fully understood. This study investigated whether breastfeeding practices are correlated with childhood maltreatment. Data were utilized from the National Longitudinal Study of Adolescent to Adult Health, a nationally representative and longitudinal study of adolescents. The analytic sample comprised 4,159 adolescents. The outcome variables included four subtypes of childhood maltreatment (neglect, inadequate supervision, physical abuse, and sexual abuse). The primary independent variable was breastfeeding duration. Covariates of the child, mother, and household were included in analyses. Logistic regression models were employed to predict odds of maltreatment subtypes from breastfeeding duration and covariates. Compared with adolescents never breastfed, adolescents breastfed 9 months or longer had a reduced odds of having experienced neglect (odds ratio [OR] = 0.54; 95% confidence interval [CI] = 0.35-0.83) and sexual abuse (OR = 0.47; 95% CI = 0.24-0.93) after controlling for covariates. Breastfeeding duration is significantly associated with decreased childhood neglect and sexual abuse. Breastfeeding practices should be explored as a consideration among clinicians when assessing maltreatment risk. Further research should examine whether a causal relationship exists between breastfeeding and decreased maltreatment.

  11. Statins Decrease Oxidative Stress and ICD Therapies

    Directory of Open Access Journals (Sweden)

    Heather L. Bloom

    2010-01-01

    Full Text Available Recent studies demonstrate that statins decrease ventricular arrhythmias in internal cardioverter defibrillator (ICD patients. The mechanism is unknown, but evidence links increased inflammatory and oxidative states with increased arrhythmias. We hypothesized that statin use decreases oxidation. Methods. 304 subjects with ICDs were surveyed for ventricular arrhythmia. Blood was analyzed for derivatives of reactive oxygen species (DROMs and interleukin-6 (IL-6. Results. Subjects included 252 (83% men, 58% on statins, 20% had ventricular arrhythmias. Average age was 63 years and ejection fraction (EF 20%. ICD implant duration was 29 ± 27 months. Use of statins correlated with lower ICD events (r=0.12, P=.02. Subjects on statins had lower hsCRP (5.2 versus 6.3; P=.05 and DROM levels (373 versus 397; P=.03. Other factors, including IL-6 and EF did not differ between statin and nonstatin use, nor did beta-blocker or antiarrhythmic use. Multivariate cross-correlation analysis demonstrated that DROMs, statins, IL-6 and EF were strongly associated with ICD events. Multivariate regression shows DROMs to be the dominant predictor. Conclusion. ICD event rate correlates with DROMs, a measure of lipid peroxides. Use of statins is associated with reduced DROMs and fewer ICD events, suggesting that statins exert their effect through reducing oxidation.

  12. Serum Soluble Corin is Decreased in Stroke.

    Science.gov (United States)

    Peng, Hao; Zhu, Fangfang; Shi, Jijun; Han, Xiujie; Zhou, Dan; Liu, Yan; Zhi, Zhongwen; Zhang, Fuding; Shen, Yun; Ma, Juanjuan; Song, Yulin; Hu, Weidong

    2015-07-01

    Soluble corin was decreased in coronary heart disease. Given the connections between cardiac dysfunction and stroke, circulating corin might be a candidate marker of stroke risk. However, the association between circulating corin and stroke has not yet been studied in humans. Here, we aimed to examine the association in patients wtith stroke and community-based healthy controls. Four hundred eighty-one patients with ischemic stroke, 116 patients with hemorrhagic stroke, and 2498 healthy controls were studied. Serum soluble corin and some conventional risk factors of stroke were examined. Because circulating corin was reported to be varied between men and women, the association between serum soluble corin and stroke was evaluated in men and women, respectively. Patients with ischemic and hemorrhagic stroke had a significantly lower level of serum soluble corin than healthy controls in men and women (all P values, stroke than men in the highest quartile. Women in the lowest quartile of serum soluble corin were also more likely to have ischemic (OR, 3.10; 95% confidence interval, 1.76-5.44) and hemorrhagic (OR, 8.54; 95% confidence interval, 2.35-31.02) stroke than women in the highest quartile. ORs of ischemic and hemorrhagic stroke were significantly increased with the decreasing levels of serum soluble corin in men and women (all P values for trend, stroke compared with healthy controls. Our findings raise the possibility that serum soluble corin may have a pathogenic role in stroke. © 2015 American Heart Association, Inc.

  13. Lifestyle Decreases Risk Factors for Cardiovascular Diseases

    Science.gov (United States)

    Slavíček, Jaroslav; Kittnar, Otomar; Fraser, Gary E.; Medová, Eva; Konečná, Jana; Žižka, Robert; Dohnalová, Alena; Novák, Vladimír

    2009-01-01

    Summary The morbidity and mortality of the cardiovascular diseases is high in the developed countries. The lifestyle changes are capable to decrease it by 50%. The aim of the present study was to measure the parameters of some risk factors before and after a one-week NEW START rehabilitative retreat. 1,349 volunteers, 320 men, 1,029 woman, mean age 51±14.5 (SD) years participated in 30 rehabilitative retreats from 1999–2006 in the Czech Republic, using a low-fat, low-energy, lacto-ovo-vegetarian diet and exercise, in a stress-free environment. Body weight, height, BMI, blood pressure, heart rate, serum cholesterol and blood glucose were measured. Body weight decreased in 1,223 measured persons from 71.2±14.38 (SD) to 70.6±14.02 kg (pSeventh-day Adventists than in controls who never observed the diet and avail the lifestyle programs. The parameters were nonsignificantly changed one year after finishing the retreat in the sample of 68 persons showing the positive effect of retreats. Our results showed, that the intake of a low-fat, low-energy diet, over the course of one week in a stress-free environment, had positive impact on the risk factors of cardiovascular diseases. PMID:19256282

  14. Effect of high density lipoproteins on permeability of rabbit aorta to low density lipoproteins

    International Nuclear Information System (INIS)

    Klimov, A.N.; Popov, V.A.; Nagornev, V.A.; Pleskov, V.M.

    1985-01-01

    A study was made on the effect of high density lipoproteins (HDL) on the permeability of rabbit aorta to low density lipoproteins (LDL) after intravenous administration of human HDL and human ( 125 I)LDL to normal and hypercholesterolemic rabbits. Evaluation of radioactivity in plasma and aorta has shown that the administration of a large dose of HDL decreased the aorta permeability rate for ( 125 I)LDL on an average by 19% in normal rabbits, and by 45% in rabbits with moderate hypercholesterolemia. A historadiographic study showed that HDL also decreased the vessel wall permeability to ( 125 I)LDL in normal and particularly in hypercholesterolemic animals. The suggestion was made that HDL at very high molar concentration can hamper LDL transportation through the intact endothelial layer into the intima due to the ability of HDL to compete with LDL in sites of low affinity on the surface of endothelial cells. (author)

  15. Tüketicilerin Sert Kabuklu Kuruyemiş Tüketim Alışkanlıkları ve Satın Alma Davranışlarının Belirlenmesi: Siirt İli Örneği

    Directory of Open Access Journals (Sweden)

    Merve Kardeş

    2018-03-01

    Full Text Available Çalışmanın amacı, Siirt ili kentsel alanda tüketicilerin sert kabuklu kuruyemiş tüketim alışkanlıkları ve satın alma davranışlarını belirlemektir. Çalışmanın ana materyalini Siirt ili kentsel alanda yaşayan 150 tüketiciden anket yoluyla toplanan veriler oluşturmaktadır. Verilerin analizinde, frekans tabloları ve tüketicilerin ailelerinde yeterli miktarda kuruyemiş tüketip tüketmedikleri düşüncesi logit model yardımıyla analiz edilmiştir. Araştırmada, ankete katılanların %62,7’si erkek, %63,3’ü 25-40 yaş grubunda, %64,0’ü evli, %62,0’si 2001-4000 TL gelir grubunda, %49,3’ü ailede yeterli miktarda kuruyemiş tüketildiği, %56,0’sı kuruyemiş tüketiminin faydaları hakkında bilgiye sahip olduğu ve %78,7’sinin kuruyemişi, kuruyemişçilerden satın aldığı belirlenmiştir. Çalışmada ayrıca ailede yeterli miktarda kuruyemiş tüketildiğini düşünme ile kuruyemiş tüketmenin faydalarını bilme arasında pozitif, cinsiyet arasında ise negatif bir ilişkini olduğu tespit edilmiştir.

  16. Super liquid density target designs

    International Nuclear Information System (INIS)

    Pan, Y.L.; Bailey, D.S.

    1976-01-01

    The success of laser fusion depends on obtaining near isentropic compression of fuel to very high densities and igniting this fuel. To date, the results of laser fusion experiments have been based mainly on the exploding pusher implosion of fusion capsules consisting of thin glass microballoons (wall thickness of less than 1 micron) filled with low density DT gas (initial density of a few mg/cc). Maximum DT densities of a few tenths of g/cc and temperatures of a few keV have been achieved in these experiments. We will discuss the results of LASNEX target design calculations for targets which: (a) can compress fuel to much higher densities using the capabilities of existing Nd-glass systems at LLL; (b) allow experimental measurement of the peak fuel density achieved

  17. A comprehensive tool for measuring mammographic density changes over time.

    Science.gov (United States)

    Eriksson, Mikael; Li, Jingmei; Leifland, Karin; Czene, Kamila; Hall, Per

    2018-06-01

    Mammographic density is a marker of breast cancer risk and diagnostics accuracy. Density change over time is a strong proxy for response to endocrine treatment and potentially a stronger predictor of breast cancer incidence. We developed STRATUS to analyse digital and analogue images and enable automated measurements of density changes over time. Raw and processed images from the same mammogram were randomly sampled from 41,353 healthy women. Measurements from raw images (using FDA approved software iCAD) were used as templates for STRATUS to measure density on processed images through machine learning. A similar two-step design was used to train density measures in analogue images. Relative risks of breast cancer were estimated in three unique datasets. An alignment protocol was developed using images from 11,409 women to reduce non-biological variability in density change. The protocol was evaluated in 55,073 women having two regular mammography screens. Differences and variances in densities were compared before and after image alignment. The average relative risk of breast cancer in the three datasets was 1.6 [95% confidence interval (CI) 1.3-1.8] per standard deviation of percent mammographic density. The discrimination was AUC 0.62 (CI 0.60-0.64). The type of image did not significantly influence the risk associations. Alignment decreased the non-biological variability in density change and re-estimated the yearly overall percent density decrease from 1.5 to 0.9%, p density measures was not influenced by mammogram type. The alignment protocol reduced the non-biological variability between images over time. STRATUS has the potential to become a useful tool for epidemiological studies and clinical follow-up.

  18. Decreased inducibility of TNF expression in lipid-loaded macrophages

    Directory of Open Access Journals (Sweden)

    Kallin Bengt

    2002-10-01

    Full Text Available Abstract Background Inflammation and immune responses are considered to be very important in the pathogenesis of atherosclerosis. Lipid accumulation in macrophages of the arterial intima is a characteristic feature of atherosclerosis which can influence the inflammatory potential of macrophages. We studied the effects of lipid loading on the regulation of TNF expression in human monocyte-derived macrophages. Results In macrophages incubated with acetylated low density lipoprotein (ac-LDL for 2 days, mRNA expression of TNF in cells stimulated with TNF decreased by 75%. In cell cultures stimulated over night with IL-1β, lipid loading decreased secretion of TNF into culture medium by 48%. These results suggest that lipid accumulation in macrophages makes them less responsive to inflammatory stimuli. Decreased basal activity and inducibility of transcription factor AP-1 was observed in lipid-loaded cells, suggesting a mechanism for the suppression of cytokine expression. NF-κB binding activity and inducibility were only marginally affected by ac-LDL. LDL and ac-LDL did not activate PPARγ. In contrast, oxidized LDL stimulated AP-1 and PPARγ but inhibited NF-κB, indicating that the effects of lipid loading with ac-LDL were not due to oxidation of lipids. Conclusions Accumulation of lipid, mainly cholesterol, results in down-regulation of TNF expression in macrophages. Since monocytes are known to be activated by cell adhesion, these results suggest that foam cells in atherosclerotic plaques may contribute less potently to an inflammatory reaction than newly arrived monocytes/macrophages.

  19. Influence of psychotherapist density and antidepressant sales on suicide rates.

    Science.gov (United States)

    Kapusta, N D; Niederkrotenthaler, T; Etzersdorfer, E; Voracek, M; Dervic, K; Jandl-Jager, E; Sonneck, G

    2009-03-01

    Antidepressant sales and suicide rates have been shown to be correlated in industrialized countries. The aim was to study the possible effects of psychotherapy utilization on suicide rates. We assessed the impact of antidepressant sales and psychotherapist density on suicide rates between 1991 and 2005. To adjust for serial correlation in time series, three first-order autoregressive models adjusted for per capita alcohol consumption and unemployment rates were employed. Antidepressant sales and the density of psychotherapists in the population were negatively associated with suicide rates. This study provides evidence that decreasing suicide rates were associated with both increasing antidepressant sales and an increasing density of psychotherapists. The decrease of suicide rates could reflect a general improvement in mental health care rather than being caused by antidepressant sales or psychotherapist density alone.

  20. High Power Density Motors

    Science.gov (United States)

    Kascak, Daniel J.

    2004-01-01

    With the growing concerns of global warming, the need for pollution-free vehicles is ever increasing. Pollution-free flight is one of NASA's goals for the 21" Century. , One method of approaching that goal is hydrogen-fueled aircraft that use fuel cells or turbo- generators to develop electric power that can drive electric motors that turn the aircraft's propulsive fans or propellers. Hydrogen fuel would likely be carried as a liquid, stored in tanks at its boiling point of 20.5 K (-422.5 F). Conventional electric motors, however, are far too heavy (for a given horsepower) to use on aircraft. Fortunately the liquid hydrogen fuel can provide essentially free refrigeration that can be used to cool the windings of motors before the hydrogen is used for fuel. Either High Temperature Superconductors (HTS) or high purity metals such as copper or aluminum may be used in the motor windings. Superconductors have essentially zero electrical resistance to steady current. The electrical resistance of high purity aluminum or copper near liquid hydrogen temperature can be l/lOO* or less of the room temperature resistance. These conductors could provide higher motor efficiency than normal room-temperature motors achieve. But much more importantly, these conductors can carry ten to a hundred times more current than copper conductors do in normal motors operating at room temperature. This is a consequence of the low electrical resistance and of good heat transfer coefficients in boiling LH2. Thus the conductors can produce higher magnetic field strengths and consequently higher motor torque and power. Designs, analysis and actual cryogenic motor tests show that such cryogenic motors could produce three or more times as much power per unit weight as turbine engines can, whereas conventional motors produce only 1/5 as much power per weight as turbine engines. This summer work has been done with Litz wire to maximize the current density. The current is limited by the amount of heat it

  1. Density functionals from deep learning

    OpenAIRE

    McMahon, Jeffrey M.

    2016-01-01

    Density-functional theory is a formally exact description of a many-body quantum system in terms of its density; in practice, however, approximations to the universal density functional are required. In this work, a model based on deep learning is developed to approximate this functional. Deep learning allows computational models that are capable of naturally discovering intricate structure in large and/or high-dimensional data sets, with multiple levels of abstraction. As no assumptions are ...

  2. Transition densities with electron scattering

    International Nuclear Information System (INIS)

    Heisenberg, J.

    1985-01-01

    This paper reviews the ground state and transition charge densities in nuclei via electron scattering. Using electrons as a spectroscopic tool in nuclear physics, these transition densities can be determined with high precision, also in the nuclear interior. These densities generally ask for a microscopic interpretation in terms of contributions from individual nucleons. The results for single particle transitions confirm the picture of particle-phonon coupling. (Auth.)

  3. Sets with Prescribed Arithmetic Densities

    Czech Academy of Sciences Publication Activity Database

    Luca, F.; Pomerance, C.; Porubský, Štefan

    2008-01-01

    Roč. 3, č. 2 (2008), s. 67-80 ISSN 1336-913X R&D Projects: GA ČR GA201/07/0191 Institutional research plan: CEZ:AV0Z10300504 Keywords : generalized arithmetic density * generalized asymptotic density * generalized logarithmic density * arithmetical semigroup * weighted arithmetic mean * ratio set * R-dense set * Axiom A * delta-regularly varying function Subject RIV: BA - General Mathematics

  4. Soil density and moisture content on two unused forest roads during first 30 months after construction

    Science.gov (United States)

    J.D. Helvey; J.N. Kochenderfer; J.N. Kochenderfer

    1990-01-01

    Reports results of soil density and soil moisture measurements on two roads in the central Appalachians over a 30-month period. Density increased slightly during the measurement period at most locations. Almost all of the density changes occurred during the first few months after construction. Moisture content decreased during the first few months after construction,...

  5. Density changes in amorphous Pd80Si20 during low temperature ion irradiation

    International Nuclear Information System (INIS)

    Schumacher, G.; Birtcher, R.C.; Rehn, L.E.

    1994-11-01

    Density changes in amorphous Pd 80 Si 20 during ion irradiation below 100K were detected by in situ HVEM measurements of the changes in specimen length as a function of ion fluence. A decrease in mass density as a function of the ion fluence was observed. The saturation value of the change in mass density was determined to be approximately -1.2%

  6. Histogram Estimators of Bivariate Densities

    National Research Council Canada - National Science Library

    Husemann, Joyce A

    1986-01-01

    One-dimensional fixed-interval histogram estimators of univariate probability density functions are less efficient than the analogous variable-interval estimators which are constructed from intervals...

  7. Decreasing barriers for nurse practitioner social entrepreneurship.

    Science.gov (United States)

    Sharp, Dayle B; Monsivais, Diane

    2014-10-01

    To describe difficulties associated with the business-related aspects of practice in role transition of rural nurse practitioners (NPs), and to give practice implications. This focused ethnographic study derived data from semi-structured interviews. Participants provided information about rural NP practice ownership and barriers. The sample consisted of 24 rural NPs living throughout the United States. The majority were 51-60 years of age (45%) and females (93%) who had been in rural practice for 1 to over 20 years. NP social entrepreneurs experience difficulties related to scope of practice, business skills, and role conflict. To decrease barriers for NP clinic ownership and management, NPs need to receive education related to financing a rural practice, legal/regulatory practices, strategic planning, leadership, and clinic management. ©2014 American Association of Nurse Practitioners.

  8. Decreasing Ambiguity of the Safety Culture Concept

    International Nuclear Information System (INIS)

    Inoue, Shiichiro; Hosoda, Satoshi; Suganuma, Takashi; Monta, Kazuo; Kameda, Akiyuki

    2001-01-01

    The status of the concept of ''safety culture'' is reviewed. It has not sufficiently taken root. One cause for this is the abstract nature of the concept. Organizations must become aware of the necessity of improving safety and have sufficient power to promote this. The culture of safety must be instilled in each employee, so that each of them will feel responsible for identifying weak points in plant safety. The authors devised a tool for a self-assessment of the safety culture. The tool will bring to light information divides, communication gaps, etc. Recognizing the vulnerabilities of the organization by themselves and discussing these weak points among them is the first step to decrease the ambiguity of the safety culture. The next step is to make these gaps known along with agreed-upon countermeasures. The concept of safety culture will be greatly clarified in this way and lead to safer nuclear power plants

  9. Importing low-density ideas to high-density revitalisation

    DEFF Research Database (Denmark)

    Arnholtz, Jens; Ibsen, Christian Lyhne; Ibsen, Flemming

    2016-01-01

    Why did union officials from a high-union-density country like Denmark choose to import an organising strategy from low-density countries such as the US and the UK? Drawing on in-depth interviews with key union officials and internal documents, the authors of this article argue two key points. Fi...

  10. On Improving Density Estimators which are not Bona Fide Functions

    OpenAIRE

    Gajek, Leslaw

    1986-01-01

    In order to improve the rate of decrease of the IMSE for nonparametric kernel density estimators with nonrandom bandwidth beyond $O(n^{-4/5})$ all current methods must relax the constraint that the density estimate be a bona fide function, that is, be nonnegative and integrate to one. In this paper we show how to achieve similar improvement without relaxing any of these constraints. The method can also be applied for orthogonal series, adaptive orthogonal series, spline, jackknife, and other ...

  11. Assessment of the toxicity of the Brazilian pepper trees Schinus terebinthifolius Raddi (Aroeira-da-praia) and Myracrodruon urundeuva Allemão (Aroeira-do-sertão).

    Science.gov (United States)

    Carlini, Elisaldo Araujo; Duarte-Almeida, Joaquim Maurício; Tabach, Ricardo

    2013-05-01

    The present study aimed to assess the preclinical toxicity of two plants commonly used to treat "stomach ailments" in Brazil: Schinus terebinthifolius Raddi (S) and Myracrodruon urundeuva Allemão (M). In male rats, chronic treatment (83 days) with both pepper trees (17.6 and 13.8 mg/kg, S and M, respectively) has been shown to decrease hematocrit. However, a reduction in the number of red blood cells and hemoglobin was only seen following administration of S. terebinthifolius. None of the plants caused anatomopathological alterations following chronic treatment, and mating ability and fertility were not affected. Both pepper trees showed moderate toxicity following acute and chronic treatment by gavage, particularly S. terebinthifolius. Moreover, bone malformations were induced in fetuses, and a slight delay in recovery time of the postural reflex was observed in pups from female animals treated (18 days) with S. terebinthifolius. Given these results, a better assessment of the risks and benefits of the internal use of these plants is necessary, especially when used by women of childbearing age. Copyright © 2012 John Wiley & Sons, Ltd.

  12. Contribuição da caatinga na sustentabilidade de projetos de assentamentos no sertão norte-rio-grandense Caatinga forest contribution to the sustainability of settlement projects on rio grande do norte backwoods

    Directory of Open Access Journals (Sweden)

    Márcio Rocha Francelino

    2003-02-01

    Full Text Available Os objetivos deste trabalho foram caracterizar os recursos florestais da caatinga e determinar a sua contribuição na sustentabilidade em projetos de reforma agrária localizados na região oeste do Estado do Rio Grande do Norte. Foi realizado um levantamento florístico, no qual se constatou que as espécies mais bem distribuídas pelas unidades amostrais foram as de caráter pioneiro, indicando que essas matas já foram exploradas anteriormente à ocupação dos assentados. O estrato florestal mais comum foi o arbustivo-arbóreo fechado, correspondendo a 75% da parcelas amostradas. Os assentamentos com presença de cobertura florestal do tipo arbustivo-arbórea aberta apresentaram baixa densidade, associada à baixa diversidade florística e à forte tendência à homogeneização, o que as enquadra como prioritárias em um processo de conservação e, ou, enriquecimento da flora. Devido à baixa rentabilidade da exploração dos recursos florestais da caatinga, essa atividade deveria servir apenas como complemento de renda dos assentados, já que outras atividades apresentam maiores retornos econômicos. Entretanto, ela possui grande importância no contexto social, sendo fundamental para a sustentabilidade dos assentamentos estudados.A floristic survey was conducted to characterize the caatinga forest resources as well as to determine its contribution to the sustainability agrarian reform projects in western Rio Grande do Norte. This survey showed that the pioneer species were better distributed in the sampling units, indicating that these forests had been explored prior to occupation by the settlers. The closed arboreal-shruby type was the most common forest stratum, and corresponded to 75% of the sampled plots. The settlements with forest cover of the open arboreal-shruby type presented low density associated with a low floristic diversity as well as a marked tendency to homogenization, making this forest cover a priority for conservation

  13. BONE MINERAL DENSITY AFTER LIVER TRANSPLANTATION

    Directory of Open Access Journals (Sweden)

    V. P. Buzulina

    2010-01-01

    Full Text Available Bone mineral density (BMD was estimated twice in 18 recipents of ortotopic liver transplantation. There was decreased BMD in axial so as in peripheral skeleton in early time and in vertebral or hip Ward triangle in late time following transplantation being lower in primary biliary cirrosis then in cirrosis following chronic virus hepatitis despite tacrolimus immunosupression without prednisolon. Tacrolimus immunosupression with prednisolon in primary biliary cirrosis patients in late postoperative time was associated with hard BMD lowering which correlated with glucocorticoid therapy duration and prednisolon cumulative dosis. 

  14. Mammography density estimation with automated volumetic breast density measurement

    International Nuclear Information System (INIS)

    Ko, Su Yeon; Kim, Eun Kyung; Kim, Min Jung; Moon, Hee Jung

    2014-01-01

    To compare automated volumetric breast density measurement (VBDM) with radiologists' evaluations based on the Breast Imaging Reporting and Data System (BI-RADS), and to identify the factors associated with technical failure of VBDM. In this study, 1129 women aged 19-82 years who underwent mammography from December 2011 to January 2012 were included. Breast density evaluations by radiologists based on BI-RADS and by VBDM (Volpara Version 1.5.1) were compared. The agreement in interpreting breast density between radiologists and VBDM was determined based on four density grades (D1, D2, D3, and D4) and a binary classification of fatty (D1-2) vs. dense (D3-4) breast using kappa statistics. The association between technical failure of VBDM and patient age, total breast volume, fibroglandular tissue volume, history of partial mastectomy, the frequency of mass > 3 cm, and breast density was analyzed. The agreement between breast density evaluations by radiologists and VBDM was fair (k value = 0.26) when the four density grades (D1/D2/D3/D4) were used and moderate (k value = 0.47) for the binary classification (D1-2/D3-4). Twenty-seven women (2.4%) showed failure of VBDM. Small total breast volume, history of partial mastectomy, and high breast density were significantly associated with technical failure of VBDM (p 0.001 to 0.015). There is fair or moderate agreement in breast density evaluation between radiologists and VBDM. Technical failure of VBDM may be related to small total breast volume, a history of partial mastectomy, and high breast density.

  15. Density Fluctuations in a Polar Coronal Hole

    Science.gov (United States)

    Hahn, Michael; D’Huys, Elke; Savin, Daniel Wolf

    2018-06-01

    We have measured the root-mean-square (rms) amplitude of intensity fluctuations, ΔI, in plume and interplume regions of a polar coronal hole. These intensity fluctuations correspond to density fluctuations. Using data from the Sun Watcher using the Active Pixel System detector and Image Processing on the Project for Onboard Autonomy (Proba2), our results extend up to a height of about 1.35 R ⊙. One advantage of the rms analysis is that it does not rely on a detailed evaluation of the power spectrum, which is limited by noise levels to low heights in the corona. The rms approach can be performed up to larger heights where the noise level is greater, provided that the noise itself can be quantified. At low heights, both the absolute ΔI, and the amplitude relative to the mean intensity, ΔI/I, decrease with height. However, starting at about 1.2 R ⊙, ΔI/I increases, reaching 20%–40% by 1.35 R ⊙. This corresponds to density fluctuations of Δn e/n e ≈ 10%–20%. The increasing relative amplitude implies that the density fluctuations are generated in the corona itself. One possibility is that the density fluctuations are generated by an instability of Alfvén waves. This generation mechanism is consistent with some theoretical models and with observations of Alfvén wave amplitudes in coronal holes. Although we find that the energy of the observed density fluctuations is small, these fluctuations are likely to play an important indirect role in coronal heating by promoting the reflection of Alfvén waves and driving turbulence.

  16. The effect of laterite density on radon diffusion behavior.

    Science.gov (United States)

    Li, Yongmei; Tan, Wanyu; Tan, Kaixuan; Liu, Zehua; Fang, Qi; Lv, Junwen; Duan, Xianzhe; Liu, Zhenzhong; Guo, Yueyue

    2018-02-01

    Radon generated in porous media such as soils and rocks migrates into indoor and outdoor air mainly by diffusion, possessing significant hazards to human health. In order to reduce these hazards of radon, it is of great importance to study the diffusion behavior of radon. In this study, we systematically measured the radon diffusion coefficient of laterite with the density ranging from 0.917gcm -3 to 2.238gcm -3 , and studied the effect of laterite density on the radon diffusion. The results show that the radon diffusion coefficient of the laterite generally decreases with the increasing laterite density. In addition, three possible relationships between the radon diffusion coefficient and the laterite density are found out as follows: (1) the linear correlation with a slope of -4.48 × 10 -6 for laterite with density ranging from 0.917 to 1.095gcm -3 , (2) the exponential correlation for laterite with density from 1.095 to 1.63gcm -3 , (3) linear correlation with a slope of -3.1 × 10 -7 for laterite with density from 1.63 to 2.238gcm -3 . The complex relationship between the radon diffusion coefficient and density is caused by the change of porosity and tortuosity of the laterite. Therefore, we suggest that a suitable density should be adopted while using the laterite to effectively cover uranium tailings or economically produce building materials that can curb the radon exhalation. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Sampling density for the quantitative evaluation of air trapping

    International Nuclear Information System (INIS)

    Goris, Michael L.; Robinson, Terry E.

    2009-01-01

    Concerns have been expressed recently about the radiation burden on patient populations, especially children, undergoing serial radiological testing. To reduce the dose one can change the CT acquisition settings or decrease the sampling density. In this study we determined the minimum desirable sampling density to ascertain the degree of air trapping in children with cystic fibrosis. Ten children with cystic fibrosis in stable condition underwent a volumetric spiral CT scan. The degree of air trapping was determined by an automated algorithm for all slices in the volume, and then for 1/2, 1/4, to 1/128 of all slices, or a sampling density ranging from 100% to 1% of the total volume. The variation around the true value derived from 100% sampling was determined for all other sampling densities. The precision of the measurement remained stable down to a 10% sampling density, but decreased markedly below 3.4%. For a disease marker with the regional variability of air trapping in cystic fibrosis, regardless of observer variability, a sampling density below 10% and even more so, below 3.4%, apparently decreases the precision of the evaluation. (orig.)

  18. Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis.

    Science.gov (United States)

    Maksud, F A N; Kakehasi, A M; Guimarães, M F B R; Machado, C J; Barbosa, A J A

    2017-05-18

    Generalized bone loss can be considered an extra-articular manifestation of rheumatoid arthritis (RA) that may lead to the occurrence of fractures, resulting in decreased quality of life and increased healthcare costs. The peptide ghrelin has demonstrated to positively affect osteoblasts in vitro and has anti-inflammatory actions, but the studies that correlate ghrelin plasma levels and RA have contradictory results. We aimed to evaluate the correlation between total ghrelin plasma levels, density of ghrelin-immunoreactive cells in the gastric mucosa, and bone mineral density (BMD) in twenty adult women with established RA with 6 months or more of symptoms (mean age of 52.70±11.40 years). Patients with RA presented higher ghrelin-immunoreactive cells density in gastric mucosa (P=0.008) compared with healthy females. There was a positive relationship between femoral neck BMD and gastric ghrelin cell density (P=0.007). However, these same patients presented a negative correlation between plasma ghrelin levels and total femoral BMD (P=0.03). The present results indicate that ghrelin may be involved in bone metabolism of patients with RA. However, the higher density of ghrelin-producing cells in the gastric mucosa of these patients does not seem to induce a corresponding elevation in the plasma levels of this peptide.

  19. Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    F.A.N. Maksud

    Full Text Available Generalized bone loss can be considered an extra-articular manifestation of rheumatoid arthritis (RA that may lead to the occurrence of fractures, resulting in decreased quality of life and increased healthcare costs. The peptide ghrelin has demonstrated to positively affect osteoblasts in vitro and has anti-inflammatory actions, but the studies that correlate ghrelin plasma levels and RA have contradictory results. We aimed to evaluate the correlation between total ghrelin plasma levels, density of ghrelin-immunoreactive cells in the gastric mucosa, and bone mineral density (BMD in twenty adult women with established RA with 6 months or more of symptoms (mean age of 52.70±11.40 years. Patients with RA presented higher ghrelin-immunoreactive cells density in gastric mucosa (P=0.008 compared with healthy females. There was a positive relationship between femoral neck BMD and gastric ghrelin cell density (P=0.007. However, these same patients presented a negative correlation between plasma ghrelin levels and total femoral BMD (P=0.03. The present results indicate that ghrelin may be involved in bone metabolism of patients with RA. However, the higher density of ghrelin-producing cells in the gastric mucosa of these patients does not seem to induce a corresponding elevation in the plasma levels of this peptide.

  20. Troubleshooting at Reverse Osmosis performance decrease

    Energy Technology Data Exchange (ETDEWEB)

    Soons, Jan [KEMA (Netherlands)

    2011-07-01

    There are several causes for a decrease in Reverse Osmosis (RO) membrane performance each of which requiring actions to tackle the possible cause. Two of the main factors affecting the performance of the system are the feed quality (poor feed quality can lead to fouling of the membranes) and the operational conditions (including the maximum allowed pressure, minimum cleaning frequencies and types, recovery rate etc, which should be according to the design conditions). If necessary, pre-treatment will be applied in order to remove the fouling agents from the influent, reduce scaling (through the addition of anti-scalants) and for the protection of the membranes (for example, sodium metabisulphite addition for the removal of residual chlorine which can harm the membranes). Fouling is not strictly limited to the use of surface water as feed water, also relatively clean water sources will, over time, lead to organic and inorganic fouling when cleaning is not optimum. When fouling occurs, the TransMembrane Pressure (TMP) increases and more energy will be needed to produce the same amount of product water. Also, the cleaning rate will increase, reducing the production rate and increasing the chemical consumption and the produced waste streams. Furthermore, the quality of the effluent will decrease (lower rejection rates at higher pressures) and the lifetime of the membranes will decrease. Depending on the type of fouling different cleaning regimes will have to be applied: acidic treatment for inorganic fouling, the addition of bases against organic fouling. Therefore, it is very important to have a clear view of the type of fouling that is occurring, in order to apply the correct treatment methods. Another important aspect to be kept in mind is that the chemistry of the water - in the first place ruled by the feed water composition - can change during passage of the modules, in particular in cases where the RO system consists of two or more RO trains, and where the

  1. Measurement and analyses of molten Ni-Co alloy density

    Institute of Scientific and Technical Information of China (English)

    XIAO Feng; K. MUKAI; FANG Liang; FU Ya; YANG Ren-hui

    2006-01-01

    With the advent of powerful mathematical modeling techniques for material phenomena, there is renewed interest in reliable data for the density of the Ni-based superalloys. Up to now, there has been few report on the density of molten Ni-Co alloy.In order to obtain more accurate density data for molten Ni-Co alloy, the density of molten Ni-Co alloy was measured with a modified sessile drop method, and the accommodation of different atoms in molten Ni-Co alloy was analyzed. The density of alloy is found to decrease with increasing temperature and Co concentration in the alloy. The molar volume of molten Ni-Co alloy increases with increasing Co concentration. The molar volume of Ni-Co alloy determined shows a positive deviation from the linear molar volume, and the deviation of molar volume from ideal mixing increases with increasing Co concentration over the experimental concentration range.

  2. Sled Towing Acutely Decreases Acceleration Sprint Time.

    Science.gov (United States)

    Wong, Megan A; Dobbs, Ian J; Watkins, Casey M; Barillas, Saldiam R; Lin, Anne; Archer, David C; Lockie, Robert G; Coburn, Jared W; Brown, Lee E

    2017-11-01

    Wong, MA, Dobbs, IJ, Watkins, C, Barillas, SR, Lin, A, Archer, DC, Lockie, RG, Coburn, JW, and Brown, LE. Sled towing acutely decreases acceleration sprint time. J Strength Cond Res 31(11): 3046-3051, 2017-Sled towing is a common form of overload training in sports to develop muscular strength for sprinting. This type of training leads to acute and chronic outcomes. Acute training potentially leads to postactivation potentiation (PAP), which is when subsequent muscle performance is enhanced after a preload stimulus. The purpose of this study was to determine differences between rest intervals after sled towing on acute sprint speed. Twenty healthy recreationally trained men (age = 22.3 ± 2.4 years, height = 176.95 ± 5.46 cm, mass = 83.19 ± 11.31 kg) who were currently active in a field sport twice a week for the last 6 months volunteered to participate. A maximal 30-meter (m) baseline (BL) body mass (BM) sprint was performed (with splits at 5, 10, 20, and 30 m) followed by 5 visits where participants sprinted 30 m towing a sled at 30% BM then rested for 2, 4, 6, 8, or 12 minutes. They were instructed to stand still during rest times. After the rest interval, they performed a maximal 30-m post-test BM sprint. Analysis of variance (ANOVA) revealed that post sled tow BM sprint times (4.47 ± 0.21 seconds) were less than BL times (4.55 ± 0.18 seconds) on an individualized rest interval basis. A follow-up 2 × 4 ANOVA showed that this decrease occurred only in the acceleration phase over the first 5 m (BL = 1.13 ± 0.08 seconds vs. Best = 1.08 ± 0.08 seconds), which may be the result of PAP and the complex relationship between fatigue and potentiation relative to the intensity of the sled tow and the rest interval. Therefore, coaches should test their athletes on an individual basis to determine optimal rest time after a 30-m 30% BM sled tow to enhance acute sprint speed.

  3. Low-frequency oscillations at high density in JFT-2

    International Nuclear Information System (INIS)

    Maeno, Masaki; Katagiri, Masaki; Suzuki, Norio; Fujisawa, Noboru

    1977-12-01

    Low-frequency oscillations in a plasma were measured with magnetic probes and Si surface-barrier detectors, and behaviour of the high density plasmas was studied. The plasma current profile in the phase of decreasing density after the interruption of gas input is more peaked than during gas input. The introduction of hydrogen during a discharge results in a reduction of the impurities flux. The increase of density by fast gas input is limited with a negative voltage spike. Immediately before a negative voltage spike, oscillations of m=1,2 grow, leading to the spike. (auth.)

  4. The Density of Sustainable Settlements

    DEFF Research Database (Denmark)

    Lauring, Michael; Silva, Victor; Jensen, Ole B.

    2010-01-01

    This paper is the initial result of a cross-disciplinary attempt to encircle an answer to the question of optimal densities of sustainable settlements. Urban density is an important component in the framework of sustainable development and influences not only the character and design of cities...

  5. Plant densities and modulation of symbiotic nitrogen fixation in soybean

    Directory of Open Access Journals (Sweden)

    Marcos Javier de Luca

    2014-06-01

    Full Text Available Soybean nitrogen (N demands can be supplied to a large extent via biological nitrogen fixation, but the mechanisms of source/sink regulating photosynthesis/nitrogen fixation in high yielding cultivars and current crop management arrangements need to be investigated. We investigated the modulation of symbiotic nitrogen fixation in soybean [Glycine max (L. Merrill] at different plant densities. A field trial was performed in southern Brazil with six treatments, including non-inoculated controls without and with N-fertilizer, both at a density of 320,000 plants ha−1, and plants inoculated with Bradyrhizobium elkanii at four densities, ranging from 40,000 to 320,000 plants ha−1. Differences in nodulation, biomass production, N accumulation and partition were observed at stage R5, but not at stage V4, indicating that quantitative and qualitative factors (such as sunlight infrared/red ratio assume increasing importance during the later stages of plant growth. Decreases in density in the inoculated treatments stimulated photosynthesis and nitrogen fixation per plant. Similar yields were obtained at the different plant densities, with decreases only at the very low density level of 40,000 plants ha−1, which was also the only treatment to show differences in seed protein and oil contents. Results confirm a fine tuning of the mechanisms of source/sink, photosynthesis/nitrogen fixation under lower plant densities. Higher photosynthesis and nitrogen fixation rates are capable of sustaining increased plant growth.

  6. Hyper-arousal decreases human visual thresholds.

    Directory of Open Access Journals (Sweden)

    Adam J Woods

    Full Text Available Arousal has long been known to influence behavior and serves as an underlying component of cognition and consciousness. However, the consequences of hyper-arousal for visual perception remain unclear. The present study evaluates the impact of hyper-arousal on two aspects of visual sensitivity: visual stereoacuity and contrast thresholds. Sixty-eight participants participated in two experiments. Thirty-four participants were randomly divided into two groups in each experiment: Arousal Stimulation or Sham Control. The Arousal Stimulation group underwent a 50-second cold pressor stimulation (immersing the foot in 0-2° C water, a technique known to increase arousal. In contrast, the Sham Control group immersed their foot in room temperature water. Stereoacuity thresholds (Experiment 1 and contrast thresholds (Experiment 2 were measured before and after stimulation. The Arousal Stimulation groups demonstrated significantly lower stereoacuity and contrast thresholds following cold pressor stimulation, whereas the Sham Control groups showed no difference in thresholds. These results provide the first evidence that hyper-arousal from sensory stimulation can lower visual thresholds. Hyper-arousal's ability to decrease visual thresholds has important implications for survival, sports, and everyday life.

  7. Decreased lymphocyte dopamine transporter in romantic lovers.

    Science.gov (United States)

    Marazziti, Donatella; Baroni, Stefano; Giannaccini, Gino; Piccinni, Armando; Mucci, Federico; Catena-Dell'Osso, Mario; Rutigliano, Grazia; Massimetti, Gabriele; Dell'Osso, Liliana

    2017-06-01

    The role of dopamine (DA) in romantic love is suggested by different evidence and is supported by the findings of some brain imaging studies. The DA transporter (DAT) is a key structure in regulating the concentration of the neurotransmitter in the synaptic cleft. Given the presence of DAT in blood cells, the present study aimed to explore it in resting lymphocytes of 30 healthy subjects of both sexes in the early stage of romantic love (no longer than 6 months), as compared with 30 subjects involved in a long-lasting relationship. All subjects had no physical or psychiatric illness. The DAT was measured by means of the [3H]-WIN 35,428 binding and the [3H]-DA reuptake to resting lymphocytes membranes. Romantic love was assessed by a specific questionnaire developed by us. The results showed that the subjects in the early phase of romantic love had a global alteration of the lymphocyte DAT involving both a decreased number of proteins (Bmax) and a reduced functionality (Vmax). Taken together, these findings would indicate the presence of increased levels of DA in romantic love that, if paralleled by similar concentrations in the brain, would explain some peculiar features of this human feeling.

  8. COGNITIVE THERAPY DECREASE THE LEVEL OF DEPRESSION

    Directory of Open Access Journals (Sweden)

    Ah. Yusuf

    2017-07-01

    Full Text Available Introduction: Aging is a natural process in individuals. Most of the elderly have problems in dealing with this natural process. Lost of occupation, friends and loneliness may result in depression in this age group. Cognitive therapy changes pessimistic idea, unrealistic hopes and excessive self evaluation may result and justify depression. Cognitive therapy may help elderly to recognize the problem in life, to develop positive objective of life and to create more positive personality. The aimed of this study was to analyze the effect of cognitive therapy to reduce the level of depression. Method: This study was used a pre experimental pre post test design. Sample were 10 elderly people who met to the inclusion criteria. The independent variable was cognitive therapy and dependent variable was the level of depression in elderly. Data were collected by using Geriatric Depression Scale (GDS 15, then analyzed by using Wilcoxon Signed Rank Test with significance levelα≤0.05. Result: The result showed that cognitive therapy has an effect on reducing depression with significance level p=0.005. Discussion: It can be concluded that cognitive therapy was effective in reducing depression level in elderly. Further studies are recommended to analyze the effect of cognitive therapy on decreasing anxiety in elderly by measuring cathecolamin.

  9. Level density of 57Co

    International Nuclear Information System (INIS)

    Mishra, V.; Boukharouba, N.; Brient, C.E.; Grimes, S.M.; Pedroni, R.S.

    1994-01-01

    Levels in 57 Co have been studied in the region of resolved levels (E 57 Fe(p,n) 57 Co neutron spectrum with resolution ΔE∼5 keV. Seventeen previously unknown levels are located. Level density parameters in the continuum region are deduced from thick target measurements of the same reaction and additional level density information is deduced from Ericson fluctuation studies of the reaction 56 Fe(p,n) 56 Co. A set of level density parameters is found which describes the level density of 57 Co at energies up to 14 MeV. Efforts to obtain level density information from the 56 Fe(d,n) 57 Co reaction were unsuccessful, but estimates of the fraction of the deuteron absorption cross section corresponding to compound nucleus formation are obtained

  10. The density of cement phases

    International Nuclear Information System (INIS)

    Balonis, M.; Glasser, F.P.

    2009-01-01

    The densities of principal crystalline phases occurring in Portland cement are critically assessed and tabulated, in some cases with addition of new data. A reliable and self-consistent density set for crystalline phases was obtained by calculating densities from crystallographic data and unit cell contents. Independent laboratory work was undertaken to synthesize major AFm and AFt cement phases, determine their unit cell parameters and compare the results with those recorded in the literature. Parameters were refined from powder diffraction patterns using CELREF 2 software. A density value is presented for each phase, showing literature sources, in some cases describing limitations on the data, and the weighting attached to numerical values where an averaging process was used for accepted data. A brief discussion is made of the consequences of the packing of water to density changes in AFm and AFt structures.

  11. Intralipid decreases apolipoprotein M levels and insulin sensitivity in rats.

    Directory of Open Access Journals (Sweden)

    Lu Zheng

    Full Text Available BACKGROUND: Apolipoprotein M (ApoM is a constituent of high-density lipoproteins (HDL. It plays a crucial role in HDL-mediated reverse cholesterol transport. Insulin resistance is associated with decreased ApoM levels. AIMS: To assess the effects of increased free fatty acids (FFAs levels after short-term Intralipid infusion on insulin sensitivity and hepatic ApoM gene expression. METHODS: Adult male Sprague-Dawley (SD rats infused with 20% Intralipid solution for 6 h. Glucose infusion rates (GIR were determined by hyperinsulinemic-euglycemic clamp during Intralipid infusion and plasma FFA levels were measured by colorimetry. Rats were sacrificed after Intralipid treatment and livers were sampled. Human embryonic kidney 293T cells were transfected with a lentivirus mediated human apoM overexpression system. Goto-Kakizaki (GK rats were injected with the lentiviral vector and insulin tolerance was assessed. Gene expression was assessed by real-time RT-PCR and PCR array. RESULTS: Intralipid increased FFAs by 17.6 folds and GIR was decreased by 27.1% compared to the control group. ApoM gene expression was decreased by 40.4% after Intralipid infusion. PPARβ/δ expression was not changed by Intralipid. Whereas the mRNA levels of Acaca, Acox1, Akt1, V-raf murine sarcoma 3611 viral oncogene homolog, G6pc, Irs2, Ldlr, Map2k1, pyruvate kinase and RBC were significantly increased in rat liver after Intralipid infusion. The Mitogen-activated protein kinase 8 (MAPK8 was significantly down-regulated in 293T cells overexpressing ApoM. Overexpression of human ApoM in GK rats could enhance the glucose-lowering effect of exogenous insulin. CONCLUSION: These results suggest that Intralipid could decrease hepatic ApoM levels. ApoM overexpression may have a potential role in improving insulin resistance in vivo and modulating apoM expression might be a future therapeutic strategy against insulin resistance in type 2 diabetes.

  12. Variable Bone Density of Scaphoid: Importance of Subchondral Screw Placement.

    Science.gov (United States)

    Swanstrom, Morgan M; Morse, Kyle W; Lipman, Joseph D; Hearns, Krystle A; Carlson, Michelle G

    2018-02-01

    Background  Ideal internal fixation of the scaphoid relies on adequate bone stock for screw purchase; so, knowledge of regional bone density of the scaphoid is crucial. Questions/Purpose  The purpose of this study was to evaluate regional variations in scaphoid bone density. Materials and Methods  Three-dimensional CT models of fractured scaphoids were created and sectioned into proximal/distal segments and then into quadrants (volar/dorsal/radial/ulnar). Concentric shells in the proximal and distal pole were constructed in 2-mm increments moving from exterior to interior. Bone density was measured in Hounsfield units (HU). Results  Bone density of the distal scaphoid (453.2 ± 70.8 HU) was less than the proximal scaphoid (619.8 ± 124.2 HU). There was no difference in bone density between the four quadrants in either pole. In both the poles, the first subchondral shell was the densest. In both the proximal and distal poles, bone density decreased significantly in all three deeper shells. Conclusion  The proximal scaphoid had a greater density than the distal scaphoid. Within the poles, there was no difference in bone density between the quadrants. The subchondral 2-mm shell had the greatest density. Bone density dropped off significantly between the first and second shell in both the proximal and distal scaphoids. Clinical Relevance  In scaphoid fracture ORIF, optimal screw placement engages the subchondral 2-mm shell, especially in the distal pole, which has an overall lower bone density, and the second shell has only two-third the density of the first shell.

  13. The Alpha value decrease when the annual individual effective dose decreases?

    International Nuclear Information System (INIS)

    Sordi, Gian M.; Marchiusi, Thiago; Sousa, Jefferson de J.

    2008-01-01

    A recent IAEA publication tells that a few entities took different alpha values for maxima individual doses. Beyond to disregard the international agencies, that recommend only one alpha value for each country, the alpha values decreases when the individual doses decreases and the practice happens exactly the conversely as we will show in this paper. We will prove that the alpha value increase when the maximum individual doses decreases in a four different manner. The first one we call the theoretical conception and it is linked to the emergent of the ALARA policy and to the purpose that led to the 3/10 of the annual limits, for to decrease the individual doses as a first resort and a 1/10 as a last resort. The second prove will be based in a small mine example used in the ICRP publication number 55 concerning to the optimization and the quantitative decision-aiding techniques in radiological protection where we will determine the alpha value ranges in which each radiological protection options becomes the analytical solution. The third prove will be based in the determination of the optimized thickness example of a plane shielding for a radiation source exposed in the ICRP publication number 37. We will use, also, the numerical example provided there. Eventually, as four prove we will show that the alpha value dos not only increases with the maximum individual dose decrease, but also, with the shielding geometry. (author)

  14. Obesity and Regional Immigrant Density.

    Science.gov (United States)

    Emerson, Scott D; Carbert, Nicole S

    2017-11-24

    Canada has an increasingly large immigrant population. Areas of higher immigrant density, may relate to immigrants' health through reduced acculturation to Western foods, greater access to cultural foods, and/or promotion of salubrious values/practices. It is unclear, however, whether an association exists between Canada-wide regional immigrant density and obesity among immigrants. Thus, we examined whether regional immigrant density was related to obesity, among immigrants. Adult immigrant respondents (n = 15,595) to a national population-level health survey were merged with region-level immigrant density data. Multi-level logistic regression was used to model the odds of obesity associated with increased immigrant density. The prevalence of obesity among the analytic sample was 16%. Increasing regional immigrant density was associated with lower odds of obesity among minority immigrants and long-term white immigrants. Immigrant density at the region-level in Canada may be an important contextual factor to consider when examining obesity among immigrants.

  15. Density dependent hadron field theory

    International Nuclear Information System (INIS)

    Fuchs, C.; Lenske, H.; Wolter, H.H.

    1995-01-01

    A fully covariant approach to a density dependent hadron field theory is presented. The relation between in-medium NN interactions and field-theoretical meson-nucleon vertices is discussed. The medium dependence of nuclear interactions is described by a functional dependence of the meson-nucleon vertices on the baryon field operators. As a consequence, the Euler-Lagrange equations lead to baryon rearrangement self-energies which are not obtained when only a parametric dependence of the vertices on the density is assumed. It is shown that the approach is energy-momentum conserving and thermodynamically consistent. Solutions of the field equations are studied in the mean-field approximation. Descriptions of the medium dependence in terms of the baryon scalar and vector density are investigated. Applications to infinite nuclear matter and finite nuclei are discussed. Density dependent coupling constants obtained from Dirac-Brueckner calculations with the Bonn NN potentials are used. Results from Hartree calculations for energy spectra, binding energies, and charge density distributions of 16 O, 40,48 Ca, and 208 Pb are presented. Comparisons to data strongly support the importance of rearrangement in a relativistic density dependent field theory. Most striking is the simultaneous improvement of charge radii, charge densities, and binding energies. The results indicate the appearance of a new ''Coester line'' in the nuclear matter equation of state

  16. Measuring single-cell density.

    Science.gov (United States)

    Grover, William H; Bryan, Andrea K; Diez-Silva, Monica; Suresh, Subra; Higgins, John M; Manalis, Scott R

    2011-07-05

    We have used a microfluidic mass sensor to measure the density of single living cells. By weighing each cell in two fluids of different densities, our technique measures the single-cell mass, volume, and density of approximately 500 cells per hour with a density precision of 0.001 g mL(-1). We observe that the intrinsic cell-to-cell variation in density is nearly 100-fold smaller than the mass or volume variation. As a result, we can measure changes in cell density indicative of cellular processes that would be otherwise undetectable by mass or volume measurements. Here, we demonstrate this with four examples: identifying Plasmodium falciparum malaria-infected erythrocytes in a culture, distinguishing transfused blood cells from a patient's own blood, identifying irreversibly sickled cells in a sickle cell patient, and identifying leukemia cells in the early stages of responding to a drug treatment. These demonstrations suggest that the ability to measure single-cell density will provide valuable insights into cell state for a wide range of biological processes.

  17. Attractor comparisons based on density

    International Nuclear Information System (INIS)

    Carroll, T. L.

    2015-01-01

    Recognizing a chaotic attractor can be seen as a problem in pattern recognition. Some feature vector must be extracted from the attractor and used to compare to other attractors. The field of machine learning has many methods for extracting feature vectors, including clustering methods, decision trees, support vector machines, and many others. In this work, feature vectors are created by representing the attractor as a density in phase space and creating polynomials based on this density. Density is useful in itself because it is a one dimensional function of phase space position, but representing an attractor as a density is also a way to reduce the size of a large data set before analyzing it with graph theory methods, which can be computationally intensive. The density computation in this paper is also fast to execute. In this paper, as a demonstration of the usefulness of density, the density is used directly to construct phase space polynomials for comparing attractors. Comparisons between attractors could be useful for tracking changes in an experiment when the underlying equations are too complicated for vector field modeling

  18. Energy vs. density on paths toward more exact density functionals.

    Science.gov (United States)

    Kepp, Kasper P

    2018-03-14

    Recently, the progression toward more exact density functional theory has been questioned, implying a need for more formal ways to systematically measure progress, i.e. a "path". Here I use the Hohenberg-Kohn theorems and the definition of normality by Burke et al. to define a path toward exactness and "straying" from the "path" by separating errors in ρ and E[ρ]. A consistent path toward exactness involves minimizing both errors. Second, a suitably diverse test set of trial densities ρ' can be used to estimate the significance of errors in ρ without knowing the exact densities which are often inaccessible. To illustrate this, the systems previously studied by Medvedev et al., the first ionization energies of atoms with Z = 1 to 10, the ionization energy of water, and the bond dissociation energies of five diatomic molecules were investigated using CCSD(T)/aug-cc-pV5Z as benchmark at chemical accuracy. Four functionals of distinct designs was used: B3LYP, PBE, M06, and S-VWN. For atomic cations regardless of charge and compactness up to Z = 10, the energy effects of the different ρ are energy-wise insignificant. An interesting oscillating behavior in the density sensitivity is observed vs. Z, explained by orbital occupation effects. Finally, it is shown that even large "normal" problems such as the Co-C bond energy of cobalamins can use simpler (e.g. PBE) trial densities to drastically speed up computation by loss of a few kJ mol -1 in accuracy. The proposed method of using a test set of trial densities to estimate the sensitivity and significance of density errors of functionals may be useful for testing and designing new balanced functionals with more systematic improvement of densities and energies.

  19. Decreased active vasodilator sensitivity in aged skin.

    Science.gov (United States)

    Kenney, W L; Morgan, A L; Farquhar, W B; Brooks, E M; Pierzga, J M; Derr, J A

    1997-04-01

    Older men and women respond to local and reflex-mediated heat stress with an attenuated increase in cutaneous vascular conductance (CVC). This study was performed to test the hypothesis that an augmented or sustained noradrenergic vasoconstriction (VC) may play a role in this age-related difference. Fifteen young (22 +/- 1 yr) and 15 older (66 +/- 1 yr) men exercised at 50% peak oxygen uptake in a 36 degrees C environment. Skin perfusion was monitored at two sites on the right forearm by laser-Doppler flowmetry: one site pretreated with bretylium tosylate (BT) to block the local release of norepinephrine and thus VC and an adjacent control site. Blockade of reflex VC was verified during whole body cooling using a water-perfused suit. CVC (perfusion divided by mean arterial pressure) at each site was reported as a percentage of the maximal CVC (%CVCmax) induced at the end of each experiment by prolonged local heating at 42 degrees C. Neither age nor BT affected the %CVCmax (75-86%) attained at high core temperatures. During the early rise phase of CVC, the %CVCmax-change in esophageal temperature (delta T(es)) curve was shifted to the right in the older men (effective delta T(es) associated with 50% CVC response for young, 0.22 +/- 0.04 and 0.39 +/- 0.04 degrees C and for older, 0.73 +/- 0.04 and 0.85 +/- 0.04 degrees C at control and BT sites, respectively). BT had no interactive effect on this age difference, suggesting a lack of involvement of the VC system in the attenuated CVC response of individuals over the age of 60 yr. Additionally, increases in skin vascular conductance were quantitatively compared by measuring increases in total forearm vascular conductance (FVC, restricted to the forearm skin under these conditions). After the initial approximately 0.2 degrees C increase in T(es), FVC was 40-50% lower in the older men (P < 0.01) for the remainder of the exercise. Decreased active vasodilator sensitivity to increasing core temperature, coupled with

  20. Density limit in JT-60

    International Nuclear Information System (INIS)

    Kamada, Yutaka; Hosogane, Nobuyuki; Hirayama, Toshio; Tsunematsu, Toshihide

    1990-05-01

    This report studies mainly the density limit for a series of gas- and pellet-fuelled limiter discharges in JT-60. With the pellet injection into high-current/low-q (q(a)=2.3∼2.5) discharges, the Murakami factor reaches up to 10∼13 x 10 19 m -2 T -1 . The values are about factors of 1.5∼2.0 higher than those for usual gas-fuelled discharges. The pellet injected discharges have high central density, whereas the electron density in the outer region (a/2 abs and n e 2 (r=50 cm) x Z eff (r=50 cm). (author)

  1. Charge density waves in solids

    CERN Document Server

    Gor'kov, LP

    2012-01-01

    The latest addition to this series covers a field which is commonly referred to as charge density wave dynamics.The most thoroughly investigated materials are inorganic linear chain compounds with highly anisotropic electronic properties. The volume opens with an examination of their structural properties and the essential features which allow charge density waves to develop.The behaviour of the charge density waves, where interesting phenomena are observed, is treated both from a theoretical and an experimental standpoint. The role of impurities in statics and dynamics is considered and an

  2. Magnetothermopower in unconventional density waves

    International Nuclear Information System (INIS)

    Dora, B.; Maki, K.; Vanyolos, A.; Virosztek, A.

    2003-10-01

    After a brief introduction on unconventional density waves (i.e. unconventional charge density wave (UCDW) and unconventional spin density wave (USDW)), we discuss the magnetotransport of the low temperature phase (LTP) of α-(BEDT-TTF) 2 KHg(SCN) 4 . Recently we have proposed that the low temperature phase in α-(BEDT-TTF) 2 KHg(SCN 4 should be UCDW. Here we show that UCDW describes very consistently the magnetothermopower of )α-(BEDT-TTF) 2 KHg(SCN) 4 observed by Choi et al. (author)

  3. The redshift number density evolution of Mg II absorption systems

    International Nuclear Information System (INIS)

    Chen Zhi-Fu

    2013-01-01

    We make use of the recent large sample of 17 042 Mg II absorption systems from Quider et al. to analyze the evolution of the redshift number density. Regardless of the strength of the absorption line, we find that the evolution of the redshift number density can be clearly distinguished into three different phases. In the intermediate redshift epoch (0.6 ≲ z ≲ 1.6), the evolution of the redshift number density is consistent with the non-evolution curve, however, the non-evolution curve over-predicts the values of the redshift number density in the early (z ≲ 0.6) and late (z ≳ 1.6) epochs. Based on the invariant cross-section of the absorber, the lack of evolution in the redshift number density compared to the non-evolution curve implies the galaxy number density does not evolve during the middle epoch. The flat evolution of the redshift number density tends to correspond to a shallow evolution in the galaxy merger rate during the late epoch, and the steep decrease of the redshift number density might be ascribed to the small mass of halos during the early epoch.

  4. FOREWORD: Special issue on density

    Science.gov (United States)

    Fujii, Kenichi

    2004-04-01

    This special issue on density was undertaken to provide readers with an overview of the present state of the density standards for solids, liquids and gases, as well as the technologies developed for measuring density. This issue also includes topics on the refractive index of gases and on techniques used for calibrating hydrometers so that almost all areas concerned with density standards are covered in four review articles and seven original articles, most of which describe current research being conducted at national metrology institutes (NMIs). A review article was invited from the Ruhr-Universität Bochum to highlight research on the magnetic suspension densimeters. In metrology, the determinations of the volume of a weight and the density of air are of primary importance in establishing a mass standard because the effect of the buoyancy force of air acting on the weight must be known accurately to determine the mass of the weight. A density standard has therefore been developed at many NMIs with a close relation to the mass standard. Hydrostatic weighing is widely used to measure the volume of a solid. The most conventional hydrostatic weighing method uses water as a primary density standard for measuring the volume of a solid. A brief history of the determination of the density of water is therefore given in a review article, as well as a recommended value for the density of water with a specified isotopic abundance. The most modern technique for hydrostatic weighing uses a solid density standard instead of water. For this purpose, optical interferometers for measuring the diameters of silicon spheres have been developed to convert the length standard into the volume standard with a small uncertainty. A review article is therefore dedicated to describing the state-of-the-art optical interferometers developed for silicon spheres. Relative combined standard uncertainties of several parts in 108 have been achieved today for measuring the volume and density of

  5. Decreased mitochondrial density and ultrastructural changes of mitochondria in cultivated skin fibroblasts of patients with Huntington´s disease

    Czech Academy of Sciences Publication Activity Database

    Rodinová, M.; Marková, M.; Kratochvílová, H.; Kučerová, I.; Tesařová, M.; Lišková, Irena; Klempíř, J.; Roth, J.; Zeman, J.; Hansíková, H.

    2015-01-01

    Roč. 78, Suppl 2 (2015), s. 20-21 ISSN 1210-7859. [Conference on Animal Models for neurodegenerative Diseases /3./. 08.11.2015-10.11.2015, Liblice] R&D Projects: GA MŠk ED2.1.00/03.0124; GA MŠk(CZ) 7F14308 Institutional support: RVO:67985904 Keywords : Huntington ´s disease * fibroblasts * mitochondrial ultrastructure Subject RIV: FH - Neurology

  6. Cholesteryl ester transfer protein decreases high-density lipoprotein and severely aggravates atherosclerosis in APOE*3-Leiden mice

    NARCIS (Netherlands)

    Westerterp, M.; Hoogt, C.C. van der; Haan, W. de; Offerman, E.H.; Dallinga-Thie, G.M.; Jukema, J.W.; Havekes, L.M.; Rensen, P.C.N.

    2006-01-01

    OBJECTIVE - The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is still undergoing debate. Therefore, we evaluated the effect of human CETP expression on atherosclerosis in APOE*3-Leiden (E3L) mice with a humanized lipoprotein profile. METHODS AND RESULTS -

  7. Monoamine oxidase A (MAO A) inhibitors decrease glioma progression

    Science.gov (United States)

    Vaikari, Vijaya Pooja; Kota, Rajesh; Chen, Kevin; Yeh, Tzu-Shao; Jhaveri, Niyati; Groshen, Susan L.; Olenyuk, Bogdan Z.; Chen, Thomas C.; Hofman, Florence M.; Shih, Jean C.

    2016-01-01

    Glioblastoma (GBM) is an aggressive brain tumor which is currently treated with temozolomide (TMZ). Tumors usually become resistant to TMZ and recur; no effective therapy is then available. Monoamine Oxidase A (MAO A) oxidizes monoamine neurotransmitters resulting in reactive oxygen species which cause cancer. This study shows that MAO A expression is increased in human glioma tissues and cell lines. MAO A inhibitors, clorgyline or the near-infrared-dye MHI-148 conjugated to clorgyline (NMI), were cytotoxic for glioma and decreased invasion in vitro. Using the intracranial TMZ-resistant glioma model, clorgyline or NMI alone or in combination with low-dose TMZ reduced tumor growth and increased animal survival. NMI was localized specifically to the tumor. Immunocytochemistry studies showed that the MAO A inhibitor reduced proliferation, microvessel density and invasion, and increased macrophage infiltration. In conclusion, we have identified MAO A inhibitors as potential novel stand-alone drugs or as combination therapy with low dose TMZ for drug-resistant gliomas. NMI can also be used as a non-invasive imaging tool. Thus has a dual function for both therapy and diagnosis. PMID:26871599

  8. Plasma surface modification of rigid contact lenses decreases bacterial adhesion.

    Science.gov (United States)

    Wang, Yingming; Qian, Xuefeng; Zhang, Xiaofeng; Xia, Wei; Zhong, Lei; Sun, Zhengtai; Xia, Jing

    2013-11-01

    Contact lens safety is an important topic in clinical studies. Corneal infections usually occur because of the use of bacteria-carrying contact lenses. The current study investigated the impact of plasma surface modification on bacterial adherence to rigid contact lenses made of fluorosilicone acrylate materials. Boston XO and XO2 contact lenses were modified using plasma technology (XO-P and XO2-P groups). Untreated lenses were used as controls. Plasma-treated and control lenses were incubated in solutions containing Staphylococcus aureus or Pseudomonas aeruginosa. MTT colorimetry, colony-forming unit counting method, and scanning electron microscopy were used to measure bacterial adhesion. MTT colorimetry measurements showed that the optical density (OD) values of XO-P and XO2-P were significantly lower than those of XO and XO2, respectively, after incubation with S. aureus (P lenses and to the XO2-P versus XO2 lenses incubated with S. aureus (P lenses incubated with P. aeruginosa (P lenses. Plasma surface modification can significantly decrease bacterial adhesion to fluorosilicone acrylate contact lenses. This study provides important evidence of a unique benefit of plasma technology in contact lens surface modification.

  9. Stop signals decrease choices for palatable foods through decreased food evaluation

    Science.gov (United States)

    Veling, Harm; Aarts, Henk; Stroebe, Wolfgang

    2013-01-01

    The present study explores whether presenting specific palatable foods in close temporal proximity of stop signals in a go/no-go task decreases subsequent evaluations of such foods among participants with a relatively high appetite. Furthermore, we tested whether any decreased evaluations could mediate subsequent food choice. Participants first received a go/no-go task in which palatable foods were consistently linked to go cues or no-go cues within participants. Next, evaluation of the palatable foods was measured as well as food choice. Replicating previous work, results show that among participants with a relatively high appetite palatable foods associated with no-go cues are less often chosen as snacks compared to when these foods are associated with go cues, whereas this manipulation did not affect participants with a relatively low appetite. Moreover, this effect was completely mediated by decreased evaluation of the palatable foods that had been associated with the no-go cues, whereas evaluation of the foods associated with go cues did not mediate this effect. Results further showed that the devaluation effect of foods associated with no-go cues was independent of the amount of pairings (4 vs. 12 vs. 24) with the no-go cues. The current findings suggest that decreased food evaluation is a mechanism that explains effects of stop signals on food choice. PMID:24324451

  10. Intercohort density dependence drives brown trout habitat selection

    Science.gov (United States)

    Ayllón, Daniel; Nicola, Graciela G.; Parra, Irene; Elvira, Benigno; Almodóvar, Ana

    2013-01-01

    Habitat selection can be viewed as an emergent property of the quality and availability of habitat but also of the number of individuals and the way they compete for its use. Consequently, habitat selection can change across years due to fluctuating resources or to changes in population numbers. However, habitat selection predictive models often do not account for ecological dynamics, especially density dependent processes. In stage-structured population, the strength of density dependent interactions between individuals of different age classes can exert a profound influence on population trajectories and evolutionary processes. In this study, we aimed to assess the effects of fluctuating densities of both older and younger competing life stages on the habitat selection patterns (described as univariate and multivariate resource selection functions) of young-of-the-year, juvenile and adult brown trout Salmo trutta. We observed all age classes were selective in habitat choice but changed their selection patterns across years consistently with variations in the densities of older but not of younger age classes. Trout of an age increased selectivity for positions highly selected by older individuals when their density decreased, but this pattern did not hold when the density of younger age classes varied. It suggests that younger individuals are dominated by older ones but can expand their range of selected habitats when density of competitors decreases, while older trout do not seem to consider the density of younger individuals when distributing themselves even though they can negatively affect their final performance. Since these results may entail critical implications for conservation and management practices based on habitat selection models, further research should involve a wider range of river typologies and/or longer time frames to fully understand the patterns of and the mechanisms underlying the operation of density dependence on brown trout habitat

  11. SYNTHESIS, CHARACTERIZATION AND DENSITY FUNCTIONAL ...

    African Journals Online (AJOL)

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    We synthesized a number of aniline derivatives containing acyl groups to compare their barriers of rotation around ... KEY WORDS: Monoacyl aniline, Synthesis, Density functional theory, Rotation barrier. INTRODUCTION. Developments in ...

  12. Vibronic coupling density and related concepts

    International Nuclear Information System (INIS)

    Sato, Tohru; Uejima, Motoyuki; Iwahara, Naoya; Haruta, Naoki; Shizu, Katsuyuki; Tanaka, Kazuyoshi

    2013-01-01

    Vibronic coupling density is derived from a general point of view as a one-electron property density. Related concepts as well as their applications are presented. Linear and nonlinear vibronic coupling density and related concepts, orbital vibronic coupling density, reduced vibronic coupling density, atomic vibronic coupling constant, and effective vibronic coupling density, illustrate the origin of vibronic couplings and enable us to design novel functional molecules or to elucidate chemical reactions. Transition dipole moment density is defined as an example of the one-electron property density. Vibronic coupling density and transition dipole moment density open a way to design light-emitting molecules with high efficiency.

  13. Cuticular antifungals in spiders: density- and condition dependence.

    Directory of Open Access Journals (Sweden)

    Daniel González-Tokman

    Full Text Available Animals living in groups face a high risk of disease contagion. In many arthropod species, cuticular antimicrobials constitute the first protective barrier that prevents infections. Here we report that group-living spiders produce cuticular chemicals which inhibit fungal growth. Given that cuticular antifungals may be costly to produce, we explored whether they can be modulated according to the risk of contagion (i.e. under high densities. For this purpose, we quantified cuticular antifungal activity in the subsocial crab spider Diaea ergandros in both natural nests and experimentally manipulated nests of varying density. We quantified the body-condition of spiders to test whether antifungal activity is condition dependent, as well as the effect of spider density on body-condition. We predicted cuticular antifungal activity to increase and body-condition to decrease with high spider densities, and that antifungal activity would be inversely related to body-condition. Contrary to our predictions, antifungal activity was neither density- nor condition-dependent. However, body-condition decreased with density in natural nests, but increased in experimental nests. We suggest that pathogen pressure is so important in nature that it maintains high levels of cuticular antifungal activity in spiders, impacting negatively on individual energetic condition. Future studies should identify the chemical structure of the isolated antifungal compounds in order to understand the physiological basis of a trade-off between disease prevention and energetic condition caused by group living, and its consequences in the evolution of sociality in spiders.

  14. Cuticular antifungals in spiders: density- and condition dependence.

    Science.gov (United States)

    González-Tokman, Daniel; Ruch, Jasmin; Pulpitel, Tamara; Ponton, Fleur

    2014-01-01

    Animals living in groups face a high risk of disease contagion. In many arthropod species, cuticular antimicrobials constitute the first protective barrier that prevents infections. Here we report that group-living spiders produce cuticular chemicals which inhibit fungal growth. Given that cuticular antifungals may be costly to produce, we explored whether they can be modulated according to the risk of contagion (i.e. under high densities). For this purpose, we quantified cuticular antifungal activity in the subsocial crab spider Diaea ergandros in both natural nests and experimentally manipulated nests of varying density. We quantified the body-condition of spiders to test whether antifungal activity is condition dependent, as well as the effect of spider density on body-condition. We predicted cuticular antifungal activity to increase and body-condition to decrease with high spider densities, and that antifungal activity would be inversely related to body-condition. Contrary to our predictions, antifungal activity was neither density- nor condition-dependent. However, body-condition decreased with density in natural nests, but increased in experimental nests. We suggest that pathogen pressure is so important in nature that it maintains high levels of cuticular antifungal activity in spiders, impacting negatively on individual energetic condition. Future studies should identify the chemical structure of the isolated antifungal compounds in order to understand the physiological basis of a trade-off between disease prevention and energetic condition caused by group living, and its consequences in the evolution of sociality in spiders.

  15. Density Distributions of Cyclotrimethylenetrinitramines (RDX)

    International Nuclear Information System (INIS)

    Hoffman, D M

    2002-01-01

    As part of the US Army Foreign Comparative Testing (FCT) program the density distributions of six samples of class 1 RDX were measured using the density gradient technique. This technique was used in an attempt to distinguish between RDX crystallized by a French manufacturer (designated insensitive or IRDX) from RDX manufactured at Holston Army Ammunition Plant (HAAP), the current source of RDX for Department of Defense (DoD). Two samples from different lots of French IRDX had an average density of 1.7958 ± 0.0008 g/cc. The theoretical density of a perfect RDX crystal is 1.806 g/cc. This yields 99.43% of the theoretical maximum density (TMD). For two HAAP RDX lots the average density was 1.786 ± 0.002 g/cc, only 98.89% TMD. Several other techniques were used for preliminary characterization of one lot of French IRDX and two lot of HAAP RDX. Light scattering, SEM and polarized optical microscopy (POM) showed that SNPE and Holston RDX had the appropriate particle size distribution for Class 1 RDX. High performance liquid chromatography showed quantities of HMX in HAAP RDX. French IRDX also showed a 1.1 C higher melting point compared to HAAP RDX in the differential scanning calorimetry (DSC) consistent with no melting point depression due to the HMX contaminant. A second part of the program involved characterization of Holston RDX recrystallized using the French process. After reprocessing the average density of the Holston RDX was increased to 1.7907 g/cc. Apparently HMX in RDX can act as a nucleating agent in the French RDX recrystallization process. The French IRDX contained no HMX, which is assumed to account for its higher density and narrower density distribution. Reprocessing of RDX from Holston improved the average density compared to the original Holston RDX, but the resulting HIRDX was not as dense as the original French IRDX. Recrystallized Holston IRDX crystals were much larger (3-500 (micro)m or more) then either the original class 1 HAAP RDX or French

  16. Density measurements in the boundary layer of the ASDEX RF heated plasma

    International Nuclear Information System (INIS)

    El Shaer, M.

    1986-11-01

    The boundary layer in the main chamber of ASDEX is diagnosed using a movable 2.2 mm microwave interferometer. The measured radial density profile decreases exponentially outside of the separatrix with three different e-folding lengths, the middle part of the profile is flatter with a larger e-folding length. The boundary density increases proportionally to the increase of the main plasmy density near the separatrix, far from the separatrix this increase is weaker. The boundary density increases with the increase of the main magnetic field in the discharge. With the application of the RF heating at the lower hybrid frequency the boundary density is submitted to a large modification. The behavior of this modification in the density profile depends on the rate of injection of the cold feeding gas. In the discharge with a constant or decreasing gas feeding rate the density profile flattens, and with an increasing rate it steepens when the RF pulse is applied. (orig.)

  17. Benazepril hydrochloride improves diabetic nephropathy and decreases proteinuria by decreasing ANGPTL-4 expression.

    Science.gov (United States)

    Xue, Lingyu; Feng, Xiaoqing; Wang, Chuanhai; Zhang, Xuebin; Sun, Wenqiang; Yu, Kebo

    2017-10-04

    This study aimed to investigate the effects of benazepril hydrochloride (BH) on proteinuria and ANGPTL-4 expression in a diabetic nephropathy (DN) rat model. A total of 72 Wistar male rats were randomly divided into three groups: normal control (NC), DN group and BH treatment (BH) groups. The DN model was induced by streptozotocin (STZ). Weight, glucose, proteinuria, biochemical indicators and the kidney weight index were examined at 8, 12 and 16 weeks. In addition, ANGPTL-4 protein and mRNA expressions were assessed by immunohistochemistry and qRT-PCR, respectively. Relationships between ANGPTL-4 and biochemical indicators were investigated using Spearman analysis. Weight was significantly lower but glucose levels were significantly higher in both the DN and BH groups than in the NC group (P Benazepril hydrochloride improves DN and decreases proteinuria by decreasing ANGPTL-4 expression.

  18. Imaginary time density-density correlations for two-dimensional electron gases at high density

    Energy Technology Data Exchange (ETDEWEB)

    Motta, M.; Galli, D. E. [Dipartimento di Fisica, Università degli Studi di Milano, Via Celoria 16, 20133 Milano (Italy); Moroni, S. [IOM-CNR DEMOCRITOS National Simulation Center and SISSA, Via Bonomea 265, 34136 Trieste (Italy); Vitali, E. [Department of Physics, College of William and Mary, Williamsburg, Virginia 23187-8795 (United States)

    2015-10-28

    We evaluate imaginary time density-density correlation functions for two-dimensional homogeneous electron gases of up to 42 particles in the continuum using the phaseless auxiliary field quantum Monte Carlo method. We use periodic boundary conditions and up to 300 plane waves as basis set elements. We show that such methodology, once equipped with suitable numerical stabilization techniques necessary to deal with exponentials, products, and inversions of large matrices, gives access to the calculation of imaginary time correlation functions for medium-sized systems. We discuss the numerical stabilization techniques and the computational complexity of the methodology and we present the limitations related to the size of the systems on a quantitative basis. We perform the inverse Laplace transform of the obtained density-density correlation functions, assessing the ability of the phaseless auxiliary field quantum Monte Carlo method to evaluate dynamical properties of medium-sized homogeneous fermion systems.

  19. Assessment of Corn Densities on Ecological Indices of Weed Species

    Directory of Open Access Journals (Sweden)

    G Mahmoodi

    2012-06-01

    Full Text Available Diversity, dominance, and stability of weeds are the most important ecological properties in agricultural systems, which influenced by management factors such as crop density, abundantly. This experiment was conducted in 2009 at Ferdowsi University of Mashhad Research Field. The experimental design was interval mapping with four levels of corn densities (5, 6, 7 and 9 plant.m-2 and four levels of weed control (full-control, without control, broad-leaves control and grasses control. Weed sampling was done at 3 stages included beginning and end of critical period weed control and harvesting time. The results showed that the effect of plant density on species diversity was significant; some how the amount of Shanon and Simpson Indices were lowest in the 9 plant.m-2 (0.39 and 0.45, respectively and greatest in 5 plant.m-2 (0.84. The results also showed that the maximum amount of dominance index was observed in 9 plant.m-2, that was seen in Echinochloa crus- galli and Convulvulus arvensis at the beginning of growing season, then in Solanum nigrum and Amaranthus retroflexus in the end of growing season. The amount of community dominance index in 9 plant.m-2 was higher than other densities, and it decreased with decline of densities. based on the results of present experiment the linear relationship between plant species and area was found. The calculated amount of Alpha and Beta diversities. in a θ and β scales based on coefficients of this relationship were 0.534 (four species per unit area and 0.29 (two species per unit area, respectively. In conclusion the result of this experiment pointed that the weeds diversity decreased with increasing of corn density, weed diversity decreased and therefore, having appropriate plant density is very efficient for sustainable weed management.

  20. Comparison of density estimators. [Estimation of probability density functions

    Energy Technology Data Exchange (ETDEWEB)

    Kao, S.; Monahan, J.F.

    1977-09-01

    Recent work in the field of probability density estimation has included the introduction of some new methods, such as the polynomial and spline methods and the nearest neighbor method, and the study of asymptotic properties in depth. This earlier work is summarized here. In addition, the computational complexity of the various algorithms is analyzed, as are some simulations. The object is to compare the performance of the various methods in small samples and their sensitivity to change in their parameters, and to attempt to discover at what point a sample is so small that density estimation can no longer be worthwhile. (RWR)

  1. Foveal cone spacing and cone photopigment density difference: objective measurements in the same subjects.

    Science.gov (United States)

    Marcos, S; Tornow, R P; Elsner, A E; Navarro, R

    1997-07-01

    Foveal cone spacing was measured in vivo using an objective technique: ocular speckle interferometry. Cone packing density was computed from cone spacing data. Foveal cone photopigment density difference was measured in the same subjects using retinal densitometry with a scanning laser ophthalmoscope. Both the cone packing density and cone photopigment density difference decreased sharply with increasing retinal eccentricity. From the comparison of both sets of measurements, the computed amounts of photopigment per cone increased slightly with increasing retinal eccentricity. Consistent with previous results, decreases in cone outer segment length are over-compensated by an increase in the outer segment area, at least in retinal eccentricities up to 1 deg.

  2. Density of biogas digestate depending on temperature and composition.

    Science.gov (United States)

    Gerber, Mandy; Schneider, Nico

    2015-09-01

    Density is one of the most important physical properties of biogas digestate to ensure an optimal dimensioning and a precise design of biogas plant components like stirring devices, pumps and heat exchangers. In this study the density of biogas digestates with different compositions was measured using pycnometers at ambient pressure in a temperature range from 293.15 to 313.15K. The biogas digestates were taken from semi-continuous experiments, in which the marine microalga Nannochloropsis salina, corn silage and a mixture of both were used as feedstocks. The results show an increase of density with increasing total solid content and a decrease with increasing temperature. Three equations to calculate the density of biogas digestate were set up depending on temperature as well as on the total solid content, organic composition and elemental composition, respectively. All correlations show a relative deviation below 1% compared to experimental data. Copyright © 2015. Published by Elsevier Ltd.

  3. Large-scale density structures in the outer heliosphere

    Science.gov (United States)

    Belcher, J. W.; Lazarus, A. J.; Mcnutt, R. L., Jr.; Gordon, G. S., Jr.

    1993-01-01

    The Plasma Science experiment on the Voyager 2 spacecraft has measured the solar wind density from 1 to 38 AU. Over this distance, the solar wind density decreases as the inverse square of the heliocentric distance. However, there are large variations in this density at a given radius. Such changes in density are the dominant cause of changes in the solar wind ram pressure in the outer heliosphere and can cause large perturbations in the location of the termination shock of the solar wind. Following a simple model suggested by Suess, we study the non-equilibrium, dynamic location of the termination shock as it responds to these pressure changes. The results of this study suggest that the termination shock is rarely if ever at its equilibrium distance and may depart from that distance by as much as 50 AU at times.

  4. Electron and current density measurements on tokamak plasmas

    International Nuclear Information System (INIS)

    Lammeren, A.C.A.P. van.

    1991-01-01

    The first part of this thesis describes the Thomson-scattering diagnostic as it was present at the TORTUR tokamak. For the first time with this diagnostic a complete tangential scattering spectrum was recorded during one single laser pulse. From this scattering spectrum the local current density was derived. Small deviations from the expected gaussian scattering spectrum were observed indicating the non-Maxwellian character of the electron-velocity distribution. The second part of this thesis describes the multi-channel interferometer/ polarimeter diagnostic which was constructed, build and operated on the Rijnhuizen Tokamak Project (RTP) tokamak. The diagnostic was operated routinely, yielding the development of the density profiles for every discharge. When ECRH (Electron Cyclotron Resonance Heating) is switched on the density profile broadens, the central density decreases and the total density increases, the opposite takes place when ECRH is switched off. The influence of MHD (magnetohydrodynamics) activity on the density was clearly observable. In the central region of the plasma it was measured that in hydrogen discharges the so-called sawtooth collapse is preceded by an m=1 instability which grows rapidly. An increase in radius of this m=1 mode of 1.5 cm just before the crash is observed. In hydrogen discharges the sawtooth induced density pulse shows an asymmetry for the high- and low-field side propagation. This asymmetry disappeared for helium discharges. From the location of the maximum density variations during an m=2 mode the position of the q=2 surface is derived. The density profiles are measured during the energy quench phase of a plasma disruption. A fast flattening and broadening of the density profile is observed. (author). 95 refs.; 66 figs.; 7 tabs

  5. Statistical theory of electron densities

    International Nuclear Information System (INIS)

    Pratt, L.R.; Hoffman, G.G.; Harris, R.A.

    1988-01-01

    An optimized Thomas--Fermi theory is proposed which retains the simplicity of the original theory and is a suitable reference theory for Monte Carlo density functional treatments of condensed materials. The key ingredient of the optimized theory is a neighborhood sampled potential which contains effects of the inhomogeneities in the one-electron potential. In contrast to the traditional Thomas--Fermi approach, the optimized theory predicts a finite electron density in the vicinity of a nucleus. Consideration of the example of an ideal electron gas subject to a central Coulomb field indicates that implementation of the approach is straightforward. The optimized theory is found to fail completely when a classically forbidden region is approached. However, these circumstances are not of primary interest for calculations of interatomic forces. It is shown how the energy functional of the density may be constructed by integration of a generalized Hellmann--Feynman relation. This generalized Hellmann--Feynman relation proves to be equivalent to the variational principle of density functional quantum mechanics, and, therefore, the present density theory can be viewed as a variational consequence of the constructed energy functional

  6. Revista USP em foco: Percorrendo o sertão

    Directory of Open Access Journals (Sweden)

    Lucia de Oliveira Almeida

    2008-10-01

    Full Text Available http://dx.doi.org/10.5007/1984-784x.2008v8n12p146 Em 1989, o reitor José Goldemberg assina o editorial de lançamento da Revista USP, no qual delineia um periódico cuja principal atribuição seria constituir-se em veículo para as pesquisas realizadas por professores e alunos da própria Universidade de São Paulo. No conjunto formado pelos quarenta primeiros fascículos, a tentativa de realização de uma leitura do presente se destaca na seção dossiê, apontada pelo próprio reitor como o espaço principal da revista. Nesses ensaios, em boa medida, o foco está concentrado na criação artística que emerge na década de oitenta e no início dos anos noventa. São textos de peculiar interesse, pois o periódico tenta olhar para o quadro enquanto a tinta ainda está fresca, visando promover um balanço no qual a música, o teatro e o cinema são analisados sem a rede de segurança que a longa distância dos anos oferece aos analistas.

  7. Dietary energy density: Applying behavioural science to weight management.

    Science.gov (United States)

    Rolls, B J

    2017-09-01

    Studies conducted by behavioural scientists show that energy density (kcal/g) provides effective guidance for healthy food choices to control intake and promote satiety. Energy density depends upon a number of dietary components, especially water (0 kcal/g) and fat (9 kcal/g). Increasing the proportion of water or water-rich ingredients, such as vegetables or fruit, lowers a food's energy density. A number of studies show that when the energy density of the diet is reduced, both adults and children spontaneously decrease their ad libitum energy intake. Other studies show that consuming a large volume of a low-energy-dense food such as soup, salad, or fruit as a first course preload can enhance satiety and reduce overall energy intake at a meal. Current evidence suggests that energy density influences intake through a complex interplay of cognitive, sensory, gastrointestinal, hormonal and neural influences. Other studies that focus on practical applications show how the strategic incorporation of foods lower in energy density into the diet allows people to eat satisfying portions while improving dietary patterns. This review discusses studies that have led to greater understanding of the importance of energy density for food intake regulation and weight management.

  8. Annual Screening Mammogram and its Relation to Breast Density

    Directory of Open Access Journals (Sweden)

    Sabek EAS

    2017-11-01

    Full Text Available Background: Current national screening programs totally depend on mammographic evaluation. After increased incidence of breast cancer in women under the age of 35, mammography sensitivity in now a question. Several factors added to decrease sensitivity of mammography, such as increased density in older age groups and increased aggressiveness of tumour biology. All these factors will change the reliability of the screening program. The study is a retrospective study conducted at Ain Shams University. Method: 138 patients diagnosed with cancer breast underwent both mammography and sonography to determine percentage of patient with more than one focus, age and density distribution breast cancer in the affected patient and accuracy of both mammography and US. Results: By studying this population, we found that around 61,44% have areas of density ranging from dense breast, heterogenous density or scattered density. These areas of density render the mammography a less sensitive tool as its sensitivity fall to 34.09%, while that of US was 77.27%. Conclusion: As breast cancer is prevalent in younger population, also with increased density in older population who are relatively insensitive to mammography, we recommended the use of Automated Breast Ultrasound (ABUS in the national screening program.

  9. VOYAGER 2 OBSERVES A LARGE DENSITY INCREASE IN THE HELIOSHEATH

    International Nuclear Information System (INIS)

    Richardson, J. D.; Wang, C.

    2012-01-01

    Voyager 2 (V2) entered the heliosheath in 2007 August at roughly the same time solar minimum conditions were reaching the outer heliosphere. Soon after crossing the termination shock the solar wind density at Voyager decreased by a factor of two and the temperature decreased by a factor of three. At the beginning of 2011 the plasma density in the heliosheath began to increase and in mid-2012 it was up by more than a factor of two. The temperature rose by about 50% and the speed remained constant, although the flow direction continues to turn tailward. These changes may signal the end of solar minimum conditions at V2 in the heliosheath, although we do not understand why the speed did not decrease. The increased dynamic pressure has lead to an outward movement of the termination shock from its very compressed state at solar minimum.

  10. Current interruption by density depression

    International Nuclear Information System (INIS)

    Wagner, J.S.; Tajima, T.; Akasofu, S.I.

    1985-04-01

    Using a one-dimensional electrostatic particle code, we examine processes associated with current interruption in a collisionless plasma when a density depression is present along the current channel. Current interruption due to double layers was suggested by Alfven and Carlqvist (1967) as a cause of solar flares. At a local density depression, plasma instabilities caused by an electron current flow are accentuated, leading to current disruption. Our simulation study encompasses a wide range of the parameters in such a way that under appropriate conditions, both the Alfven and Carlqvist (1967) regime and the Smith and Priest (1972) regime take place. In the latter regime the density depression decays into a stationary structure (''ion-acoustic layer'') which spawns a series of ion-acoustic ''solitons'' and ion phase space holes travelling upstream. A large inductance of the current circuit tends to enhance the plasma instabilities

  11. Sleep spindle density in narcolepsy

    DEFF Research Database (Denmark)

    Christensen, Julie Anja Engelhard; Nikolic, Miki; Hvidtfelt, Mathias

    2017-01-01

    BACKGROUND: Patients with narcolepsy type 1 (NT1) show alterations in sleep stage transitions, rapid-eye-movement (REM) and non-REM sleep due to the loss of hypocretinergic signaling. However, the sleep microstructure has not yet been evaluated in these patients. We aimed to evaluate whether...... the sleep spindle (SS) density is altered in patients with NT1 compared to controls and patients with narcolepsy type 2 (NT2). METHODS: All-night polysomnographic recordings from 28 NT1 patients, 19 NT2 patients, 20 controls (C) with narcolepsy-like symptoms, but with normal cerebrospinal fluid hypocretin...... levels and multiple sleep latency tests, and 18 healthy controls (HC) were included. Unspecified, slow, and fast SS were automatically detected, and SS densities were defined as number per minute and were computed across sleep stages and sleep cycles. The between-cycle trends of SS densities in N2...

  12. High Energy Density Laboratory Astrophysics

    CERN Document Server

    Lebedev, Sergey V

    2007-01-01

    During the past decade, research teams around the world have developed astrophysics-relevant research utilizing high energy-density facilities such as intense lasers and z-pinches. Every two years, at the International conference on High Energy Density Laboratory Astrophysics, scientists interested in this emerging field discuss the progress in topics covering: - Stellar evolution, stellar envelopes, opacities, radiation transport - Planetary Interiors, high-pressure EOS, dense plasma atomic physics - Supernovae, gamma-ray bursts, exploding systems, strong shocks, turbulent mixing - Supernova remnants, shock processing, radiative shocks - Astrophysical jets, high-Mach-number flows, magnetized radiative jets, magnetic reconnection - Compact object accretion disks, x-ray photoionized plasmas - Ultrastrong fields, particle acceleration, collisionless shocks. These proceedings cover many of the invited and contributed papers presented at the 6th International Conference on High Energy Density Laboratory Astrophys...

  13. Energy vs. density on paths toward exact density functionals

    DEFF Research Database (Denmark)

    Kepp, Kasper Planeta

    2018-01-01

    Recently, the progression toward more exact density functional theory has been questioned, implying a need for more formal ways to systematically measure progress, i.e. a “path”. Here I use the Hohenberg-Kohn theorems and the definition of normality by Burke et al. to define a path toward exactness...

  14. Density dependence of the nuclear energy-density functional

    Science.gov (United States)

    Papakonstantinou, Panagiota; Park, Tae-Sun; Lim, Yeunhwan; Hyun, Chang Ho

    2018-01-01

    Background: The explicit density dependence in the coupling coefficients entering the nonrelativistic nuclear energy-density functional (EDF) is understood to encode effects of three-nucleon forces and dynamical correlations. The necessity for the density-dependent coupling coefficients to assume the form of a preferably small fractional power of the density ρ is empirical and the power is often chosen arbitrarily. Consequently, precision-oriented parametrizations risk overfitting in the regime of saturation and extrapolations in dilute or dense matter may lose predictive power. Purpose: Beginning with the observation that the Fermi momentum kF, i.e., the cubic root of the density, is a key variable in the description of Fermi systems, we first wish to examine if a power hierarchy in a kF expansion can be inferred from the properties of homogeneous matter in a domain of densities, which is relevant for nuclear structure and neutron stars. For subsequent applications we want to determine a functional that is of good quality but not overtrained. Method: For the EDF, we fit systematically polynomial and other functions of ρ1 /3 to existing microscopic, variational calculations of the energy of symmetric and pure neutron matter (pseudodata) and analyze the behavior of the fits. We select a form and a set of parameters, which we found robust, and examine the parameters' naturalness and the quality of resulting extrapolations. Results: A statistical analysis confirms that low-order terms such as ρ1 /3 and ρ2 /3 are the most relevant ones in the nuclear EDF beyond lowest order. It also hints at a different power hierarchy for symmetric vs. pure neutron matter, supporting the need for more than one density-dependent term in nonrelativistic EDFs. The functional we propose easily accommodates known or adopted properties of nuclear matter near saturation. More importantly, upon extrapolation to dilute or asymmetric matter, it reproduces a range of existing microscopic

  15. Simulating QCD at finite density

    CERN Document Server

    de Forcrand, Philippe

    2009-01-01

    In this review, I recall the nature and the inevitability of the "sign problem" which plagues attempts to simulate lattice QCD at finite baryon density. I present the main approaches used to circumvent the sign problem at small chemical potential. I sketch how one can predict analytically the severity of the sign problem, as well as the numerically accessible range of baryon densities. I review progress towards the determination of the pseudo-critical temperature T_c(mu), and towards the identification of a possible QCD critical point. Some promising advances with non-standard approaches are reviewed.

  16. Momentum density maps for molecules

    International Nuclear Information System (INIS)

    Cook, J.P.D.; Brion, C.E.

    1982-01-01

    Momentum-space and position-space molecular orbital density functions computed from LCAO-MO-SCF wavefunctions are used to rationalize the shapes of some momentum distributions measured by binary (e,2e) spectroscopy. A set of simple rules is presented which enable one to sketch the momentum density function and the momentum distribution from a knowledge of the position-space wavefunction and the properties and effects of the Fourier Transform and the spherical average. Selected molecular orbitals of H 2 , N 2 and CO 2 are used to illustrate this work

  17. Photoionization and High Density Gas

    Science.gov (United States)

    Kallman, T.; Bautista, M.; White, Nicholas E. (Technical Monitor)

    2002-01-01

    We present results of calculations using the XSTAR version 2 computer code. This code is loosely based on the XSTAR v.1 code which has been available for public use for some time. However it represents an improvement and update in several major respects, including atomic data, code structure, user interface, and improved physical description of ionization/excitation. In particular, it now is applicable to high density situations in which significant excited atomic level populations are likely to occur. We describe the computational techniques and assumptions, and present sample runs with particular emphasis on high density situations.

  18. Flashing coupled density wave oscillation

    International Nuclear Information System (INIS)

    Jiang Shengyao; Wu Xinxin; Zhang Youjie

    1997-07-01

    The experiment was performed on the test loop (HRTL-5), which simulates the geometry and system design of the 5 MW reactor. The phenomenon and mechanism of different kinds of two-phase flow instabilities, namely geyser instability, flashing instability and flashing coupled density wave instability are described. The especially interpreted flashing coupled density wave instability has never been studied well, it is analyzed by using a one-dimensional non-thermo equilibrium two-phase flow drift model computer code. Calculations are in good agreement with the experiment results. (5 refs.,5 figs., 1 tab.)

  19. High-density multicore fibers

    DEFF Research Database (Denmark)

    Takenaga, K.; Matsuo, S.; Saitoh, K.

    2016-01-01

    High-density single-mode multicore fibers were designed and fabricated. A heterogeneous 30-core fiber realized a low crosstalk of −55 dB. A quasi-single-mode homogeneous 31-core fiber attained the highest core count as a single-mode multicore fiber.......High-density single-mode multicore fibers were designed and fabricated. A heterogeneous 30-core fiber realized a low crosstalk of −55 dB. A quasi-single-mode homogeneous 31-core fiber attained the highest core count as a single-mode multicore fiber....

  20. High density operation in pulsator

    International Nuclear Information System (INIS)

    Klueber, O.; Cannici, B.; Engelhardt, W.; Gernhardt, J.; Glock, E.; Karger, F.; Lisitano, G.; Mayer, H.M.; Meisel, D.; Morandi, P.

    1976-03-01

    This report summarizes the results of experiments at high electron densities (>10 14 cm -3 ) which have been achieved by pulsed gas inflow during the discharge. At these densities a regime is established which is characterized by βsub(p) > 1, nsub(i) approximately nsub(e), Tsub(i) approximately Tsub(e) and tausub(E) proportional to nsub(e). Thus the toroidal magnetic field contributes considerably to the plasma confinement and the ions constitute almost half of the plasma pressure. Furthermore, the confinement is appreciably improved and the plasma becomes impermeable to hot neutrals. (orig.) [de

  1. Intermittent pressure decreases human keratinocyte proliferation in vitro.

    Science.gov (United States)

    Nasca, Maria R; Shih, Alan T; West, Dennis P; Martinez, Wanda M; Micali, Giuseppe; Landsman, Adam S

    2007-01-01

    The aim of this study was to investigate the correlation between pressure changes and keratinocyte proliferation by determining whether keratinocytes exposed to altered mechanical pressures would proliferate at different rates compared to control cells not subjected to pressure changes. Tissue culture flasks of human keratinocytes plated at an approximate density of 15,000 cells/cm(2) undergoing an intermittent cyclic pressure of 362 mm Hg at a frequency of 2.28 or 5.16 cycles/min (0.038 or 0.086 Hz) for 8 h were compared to control flasks grown at ambient room pressure. An in-line pressure transducer was used to monitor and adjust pressure within the cell chambers, using a solenoid valve. A thymidine incorporation assay assessed the amount of cell proliferation in each set of experiments. Differences in proliferation between keratinocytes subjected to cyclic pressure changes and control cells were found to be statistically significant (p < 0.05) in 4 out of 5 proliferation assays. Also, a higher frequency of pressure changes consistently generated a reduced proliferation rate compared to that seen in cells exposed to a lower frequency of pressure changes. These data indicate that keratinocytes undergoing intermittent pressure changes exhibit decreased proliferation rates compared to controls. Furthermore, an increased frequency rate seems to have a greater effect on proliferation than low-frequency rate pressure changes, suggesting that the stress caused by frequently changed pressure may play a greater role in reducing keratinocyte proliferation than the actual magnitude of load applied to the cells. Our results support the current treatment protocol of reducing speed and duration of walking on the site of the wound to promote healing of foot ulcers. (c) 2007 S. Karger AG, Basel.

  2. Methylenedioxymethamphetamine (MDMA, 'Ecstasy': Neurodegeneration versus Neuromodulation

    Directory of Open Access Journals (Sweden)

    Elena Puerta

    2011-07-01

    Full Text Available The amphetamine analogue 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’ is widely abused as a recreational drug due to its unique psychological effects. Of interest, MDMA causes long-lasting deficits in neurochemical and histological markers of the serotonergic neurons in the brain of different animal species. Such deficits include the decline in the activity of tryptophan hydroxylase in parallel with the loss of 5-HT and its main metabolite 5-hydoxyindoleacetic acid (5-HIAA along with a lower binding of specific ligands to the 5-HT transporters (SERT. Of concern, reduced 5-HIAA levels in the CSF and SERT density have also been reported in human ecstasy users, what has been interpreted to reflect the loss of serotonergic fibers and terminals. The neurotoxic potential of MDMA has been questioned in recent years based on studies that failed to show the loss of the SERT protein by western blot or the lack of reactive astrogliosis after MDMA exposure. In addition, MDMA produces a long-lasting down-regulation of SERT gene expression; which, on the whole, has been used to invoke neuromodulatory mechanisms as an explanation to MDMA-induced 5-HT deficits. While decreased protein levels do not necessarily reflect neurodegeneration, the opposite is also true, that is, neuroregulatory mechanisms do not preclude the existence of 5-HT terminal degeneration.

  3. Decreasing child mortality, spatial clustering and decreasing disparity in North-Western Burkina Faso.

    Science.gov (United States)

    Becher, Heiko; Müller, Olaf; Dambach, Peter; Gabrysch, Sabine; Niamba, Louis; Sankoh, Osman; Simboro, Seraphin; Schoeps, Anja; Stieglbauer, Gabriele; Yé, Yazoume; Sié, Ali

    2016-04-01

    Within relatively small areas, there exist high spatial variations of mortality between villages. In rural Burkina Faso, with data from 1993 to 1998, clusters of particularly high child mortality were identified in the population of the Nouna Health and Demographic Surveillance System (HDSS), a member of the INDEPTH Network. In this paper, we report child mortality with respect to temporal trends, spatial clustering and disparity in this HDSS from 1993 to 2012. Poisson regression was used to describe village-specific child mortality rates and time trends in mortality. The spatial scan statistic was used to identify villages or village clusters with higher child mortality. Clustering of mortality in the area is still present, but not as strong as before. The disparity of child mortality between villages has decreased. The decrease occurred in the context of an overall halving of child mortality in the rural area of Nouna HDSS between 1993 and 2012. Extrapolated to the Millennium Development Goals target period 1990-2015, this yields an estimated reduction of 54%, which is not too far off the aim of a two-thirds reduction. © 2016 John Wiley & Sons Ltd.

  4. Kaon Condensation in Neutron Stars and High Density Behaviour of Nuclear Symmetry Energy

    International Nuclear Information System (INIS)

    Kubis, S.; Kutschera, M.

    1999-01-01

    We study the influence of a high density behaviour of the nuclear symmetry energy on a kaon condensation in neutron stars. We find that the symmetry energy typical for several realistic nuclear potentials, which decreases at high densities, inhibits kaon condensation for weaker kaon-nucleon couplings at any density. There exists a threshold coupling above which the kaon condensate forms at densities exceeding some critical value. This is in contrast to the case of rising symmetry energy, as e.g. for relativistic mean field models, when the kaon condensate can form for any coupling at a sufficiently high density. Properties of the condensate are also different in both cases. (author)

  5. Kaon Condensation in Neutron Stars and High Density Behaviour of Nuclear Symmetry Energy

    International Nuclear Information System (INIS)

    Kubis, S.; Kutschera, M.

    1999-04-01

    We study the influence of a high density behaviour of the nuclear symmetry energy on a kaon condensation in neutron stars. We find that the symmetry energy typical for several realistic nuclear potentials, which decreases at high densities, inhibits kaon condensation for weaker kaon-nucleon couplings at any density. There exists a threshold coupling above which the kaon condensate forms at densities exceeding some critical value. This is in contrast to the case of rising symmetry energy, as e.g. for relativistic mean field models, when the kaon condensate can form for any coupling at a sufficiently high density. Properties of the condensate are also different in both cases

  6. Transport simulations of a density limit in radiation-dominated tokamak discharges: II

    International Nuclear Information System (INIS)

    Stotler, D.P.

    1991-05-01

    The procedures developed previously to simulate the radiatively induced tokamak density limit are used to examine in more detail the scaling of the density limit. It is found that the maximum allowable density increases with auxiliary power and decreases with impurity concentration. However, it is demonstrated that there is little dependence of the density limit on plasma elongation. These trends are consistent with experimental results. Our previous work used coronal equilibrium impurities; the primary result of that paper was that the maximum density increases with current when peaked profiles are assumed. Here, this behavior is shown to occur with a coronal nonequilibrium impurity as well. 26 refs., 4 figs

  7. On radii of nuclear potential and density

    International Nuclear Information System (INIS)

    Bal'butsev, E.B.; Mikhajlov, I.N.

    1975-01-01

    The Saxon-Woods potential is widely used as an average field in different nuclear models: upsilon(r)=-upsilonsub(0)parameters: upsilonsub(0) is the well depth, Rsub(v) is the well width, a is the diffusivity of the potential edge. The potential parameters should be determined from the data on the nuclear matter distribution. The data available is in agreement with the formula for density: rho(r)=rhosub(0)same sense as Rsub(v), a. The experimental data show that Rsub(v) by 1 Fermi exceed Rsub(rho) approximately. There exist some suggestions that it caused by the finiteness of the radius of action of nuclear forces. It is noted that finiteness of radius of action of forces is a sufficient condition for the presence of this effect. A model is considered in which the matter is limited with a plane surface, so that the density depends only on a single spatial variable normal to the boundary of matter. As is shown by the results, the radius of nuclear potential exceeds that of the volume of the nuclear matter by 0.6 Fermi approximately. The mechanism of this phenomenon takes its origin from a quantum-mechanical effect of turning the wave functions into zero near the infinitely high wall and from their considerable decreasing near the wall of a finite height

  8. Creating Great Neighborhoods: Density in Your Community

    Science.gov (United States)

    This report highlights nine community-led efforts to create vibrant neighborhoods through density, discusses the connections between smart growth and density, and introduces design principles to ensure that density becomes a community asset.

  9. Level densities in nuclear physics

    International Nuclear Information System (INIS)

    Beckerman, M.

    1978-01-01

    In the independent-particle model nucleons move independently in a central potential. There is a well-defined set of single- particle orbitals, each nucleon occupies one of these orbitals subject to Fermi statistics, and the total energy of the nucleus is equal to the sum of the energies of the individual nucleons. The basic question is the range of validity of this Fermi gas description and, in particular, the roles of the residual interactions and collective modes. A detailed examination of experimental level densities in light-mass system is given to provide some insight into these questions. Level densities over the first 10 MeV or so in excitation energy as deduced from neutron and proton resonances data and from spectra of low-lying bound levels are discussed. To exhibit some of the salient features of these data comparisons to independent-particle (shell) model calculations are presented. Shell structure is predicted to manifest itself through discontinuities in the single-particle level density at the Fermi energy and through variatons in the occupancy of the valence orbitals. These predictions are examined through combinatorial calculations performed with the Grover [Phys. Rev., 157, 832(1967), 185 1303(1969)] odometer method. Before the discussion of the experimenta results, statistical mechanical level densities for spherical nuclei are reviewed. After consideration of deformed nuclei, the conclusions resulting from this work are drawn. 7 figures, 3 tables

  10. Solar corona electron density distribution

    International Nuclear Information System (INIS)

    Esposito, P.B.; Edenhofer, P.; Lueneburg, E.

    1980-01-01

    Three and one-half months of single-frequency (f= 0 2.2 x 10 9 Hz) time delay data (earth-to-spacecraft and return signal travel time) were acquired from the Helios 2 spacecraft around the time of its solar occupation (May 16, 1976). Following the determination of the spacecraft trajectory the excess time delay due to the integrated effect of free electrons along the signal's ray path could be separated and modeled. An average solar corona, equatorial, electron density profile, during solar minimum, was deduced from time delay measurements acquired within 5--60 solar radii (R/sub S/) of the sun. As a point of reference, at 10 R/sub S/ from the sun we find an average electron density of 4500 el cm -3 . However, there appears to be an asymmtry in the electron density as the ray path moved from the west (preoccultation) to east (post-occulation) solar limb. This may be related to the fact that during entry into occulation the heliographic latitude of the ray path (at closes approach to the sun) was about 6 0 , whereas during exit it became -7 0 . The Helios electron density model is compared with similar models deduced from a variety of different experimental techniques. Within 5--20 R/sub S/ of the sun the models separate according to solar minimum or maximum conditions; however, anomalies are evident

  11. Electron densities in planetary nebulae

    International Nuclear Information System (INIS)

    Stanghellini, L.; Kaler, J.B.

    1989-01-01

    Electron densities for 146 planetary nebulae have been obtained for analyzing a large sample of forbidden lines by interpolating theoretical curves obtained from solutions of the five-level atoms using up-to-date collision strengths and transition probabilities. Electron temperatures were derived from forbidden N II and/or forbidden O III lines or were estimated from the He II 4686 A line strengths. The forbidden O II densities are generally lower than those from forbidden Cl III by an average factor of 0.65. For data sets in which forbidden O II and forbidden S II were observed in common, the forbidden O II values drop to 0.84 that of the forbidden S II, implying that the outermost parts of the nebulae might have elevated densities. The forbidden Cl II and forbidden Ar IV densities show the best correlation, especially where they have been obtained from common data sets. The data give results within 30 percent of one another, assuming homogeneous nebulae. 106 refs

  12. High density matter at RHIC

    Indian Academy of Sciences (India)

    QCD predicts a phase transition between hadronic matter and a quark-gluon plasma at high energy density. The relativistic heavy ion collider (RHIC) at Brookhaven National Laboratory is a new facility dedicated to the experimental study of matter under extreme conditions. Already the first round of experimental results at ...

  13. density-dependent selection revisited

    Indian Academy of Sciences (India)

    Unknown

    is a more useful way of looking at density-dependent selection, and then go on ... these models was that the condition for maintenance of ... In a way, their formulation may be viewed as ... different than competition among species, and typical.

  14. Modern charge-density analysis

    CERN Document Server

    Gatti, Carlo

    2012-01-01

    Focusing on developments from the past 10-15 years, this volume presents an objective overview of the research in charge density analysis. The most promising methodologies are included, in addition to powerful interpretative tools and a survey of important areas of research.

  15. Optimization of Barron density estimates

    Czech Academy of Sciences Publication Activity Database

    Vajda, Igor; van der Meulen, E. C.

    2001-01-01

    Roč. 47, č. 5 (2001), s. 1867-1883 ISSN 0018-9448 R&D Projects: GA ČR GA102/99/1137 Grant - others:Copernicus(XE) 579 Institutional research plan: AV0Z1075907 Keywords : Barron estimator * chi-square criterion * density estimation Subject RIV: BD - Theory of Information Impact factor: 2.077, year: 2001

  16. High current density ion source

    International Nuclear Information System (INIS)

    King, H.J.

    1977-01-01

    A high-current-density ion source with high total current is achieved by individually directing the beamlets from an electron bombardment ion source through screen and accelerator electrodes. The openings in these screen and accelerator electrodes are oriented and positioned to direct the individual beamlets substantially toward a focus point. 3 figures, 1 table

  17. The density limit in Tokamaks

    International Nuclear Information System (INIS)

    Alladio, F.

    1985-01-01

    A short summary of the present status of experimental observations, theoretical ideas and understanding of the density limit in tokamaks is presented. It is the result of the discussion that was held on this topic at the 4th European Tokamak Workshop in Copenhagen (December 4th to 6th, 1985). 610 refs

  18. Density estimation from local structure

    CSIR Research Space (South Africa)

    Van der Walt, Christiaan M

    2009-11-01

    Full Text Available Mixture Model (GMM) density function of the data and the log-likelihood scores are compared to the scores of a GMM trained with the expectation maximization (EM) algorithm on 5 real-world classification datasets (from the UCI collection). They show...

  19. Dual model for parton densities

    International Nuclear Information System (INIS)

    El Hassouni, A.; Napoly, O.

    1981-01-01

    We derive power-counting rules for quark densities near x=1 and x=0 from parton interpretations of one-particle inclusive dual amplitudes. Using these rules, we give explicit expressions for quark distributions (including charm) inside hadrons. We can then show the compatibility between fragmentation and recombination descriptions of low-p/sub perpendicular/ processes

  20. Micro Coriolis Gas Density Sensor

    NARCIS (Netherlands)

    Sparreboom, Wouter; Ratering, Gijs; Kruijswijk, Wim; van der Wouden, E.J.; Groenesteijn, Jarno; Lötters, Joost Conrad

    2017-01-01

    In this paper we report on gas density measurements using a micro Coriolis sensor. The technology to fabricate the sensor is based on surface channel technology. The measurement tube is freely suspended and has a wall thickness of only 1 micron. This renders the sensor extremely sensitive to changes

  1. Method of measuring surface density

    International Nuclear Information System (INIS)

    Gregor, J.

    1982-01-01

    A method is described of measuring surface density or thickness, preferably of coating layers, using radiation emitted by a suitable radionuclide, e.g., 241 Am. The radiation impinges on the measured material, e.g., a copper foil and in dependence on its surface density or thickness part of the flux of impinging radiation is reflected and part penetrates through the material. The radiation which has penetrated through the material excites in a replaceable adjustable backing characteristic radiation of an energy close to that of the impinging radiation (within +-30 keV). Part of the flux of the characteristic radiation spreads back to the detector, penetrates through the material in which in dependence on surface density or thickness of the coating layer it is partly absorbed. The flux of the penetrated characteristic radiation impinging on the face of the detector is a function of surface density or thickness. Only that part of the energy is evaluated of the energy spectrum which corresponds to the energy of characteristic radiation. (B.S.)

  2. Information Density and Syntactic Repetition

    Science.gov (United States)

    Temperley, David; Gildea, Daniel

    2015-01-01

    In noun phrase (NP) coordinate constructions (e.g., NP and NP), there is a strong tendency for the syntactic structure of the second conjunct to match that of the first; the second conjunct in such constructions is therefore low in syntactic information. The theory of uniform information density predicts that low-information syntactic…

  3. Densities of molten Ni-(Cr, Co, W) superalloys

    Institute of Scientific and Technical Information of China (English)

    XIAO Feng; YANG Ren-hui; FANG Liang; LIU Lan-xiao; ZHAO Hong-kai

    2008-01-01

    In order to obtain more accurate density for molten Ni-(Cr, Co, W) binary alloy, the densities of molten pure Ni and Ni-Cr, Ni-Co, Ni-W alloys were measured with a sessile drop method. It is found that the measured densities of molten pure Ni and Ni-Cr, Ni-Co, Ni-W alloys decrease with increasing temperature in the experimental temperature range. The density of alloys increases with increasing W and Co concentrations while it decreases with increasing Cr concentration in the alloy at 1 773-1 873 K. The molar volume of Ni-based alloys increases with increasing W concentration while it decreases with increasing Co concentration. The effect of Cr concentration on the molar volume of the alloy is little in the studied concentration range. The accommodation among atomic species was analyzed. The deviation of molar volume from ideal mixing shows an ideal mixing of Ni-(Cr, Co, W) binary alloys.

  4. BMT decreases HFD-induced weight gain associated with decreased preadipocyte number and insulin secretion.

    Directory of Open Access Journals (Sweden)

    Saeed Katiraei

    Full Text Available Experimental bone marrow transplantation (BMT in mice is commonly used to assess the role of immune cell-specific genes in various pathophysiological settings. The application of BMT in obesity research is hampered by the significant reduction in high-fat diet (HFD-induced obesity. We set out to characterize metabolic tissues that may be affected by the BMT procedure and impair the HFD-induced response. Male C57BL/6 mice underwent syngeneic BMT using lethal irradiation. After a recovery period of 8 weeks they were fed a low-fat diet (LFD or HFD for 16 weeks. HFD-induced obesity was reduced in mice after BMT as compared to HFD-fed control mice, characterized by both a reduced fat (-33%; p<0.01 and lean (-11%; p<0.01 mass, while food intake and energy expenditure were unaffected. As compared to control mice, BMT-treated mice had a reduced mature adipocyte volume (approx. -45%; p<0.05 and reduced numbers of preadipocytes (-38%; p<0.05 and macrophages (-62%; p<0.05 in subcutaneous, gonadal and visceral white adipose tissue. In BMT-treated mice, pancreas weight (-46%; p<0.01 was disproportionally decreased. This was associated with reduced plasma insulin (-68%; p<0.05 and C-peptide (-37%; p<0.01 levels and a delayed glucose clearance in BMT-treated mice on HFD as compared to control mice. In conclusion, the reduction in HFD-induced obesity after BMT in mice is at least partly due to alterations in the adipose tissue cell pool composition as well as to a decreased pancreatic secretion of the anabolic hormone insulin. These effects should be considered when interpreting results of experimental BMT in metabolic studies.

  5. The topology of the Coulomb potential density. A comparison with the electron density, the virial energy density, and the Ehrenfest force density.

    Science.gov (United States)

    Ferreira, Lizé-Mari; Eaby, Alan; Dillen, Jan

    2017-12-15

    The topology of the Coulomb potential density has been studied within the context of the theory of Atoms in Molecules and has been compared with the topologies of the electron density, the virial energy density and the Ehrenfest force density. The Coulomb potential density is found to be mainly structurally homeomorphic with the electron density. The Coulomb potential density reproduces the non-nuclear attractor which is observed experimentally in the molecular graph of the electron density of a Mg dimer, thus, for the first time ever providing an alternative and energetic foundation for the existence of this critical point. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  6. Chain length dependence of the critical density of organic homologous series

    DEFF Research Database (Denmark)

    Kontogeorgis, Georgios M.; Fredenslund, Aage; Tassios, Dimitrios P.

    1995-01-01

    Whether the critical density of organic compounds belonging to a certain homologous series increases or decreases with (increasing) molecular weight has been a challenging question over the years. Two sets of experimental data have recently appeared in the literature for the critical density of n......-alkanes: Steele's data (up to n-decane) suggest that critical density increases with carbon number and reaches a limiting value. On the other hand, the data of Teja et al., 1990 which cover a broader range of n-alkanes (up to n-octadecane), reveal a decreasing trend of the critical density after a maximum at n......-heptane. Teja et al. have also presented critical density measurements for 1-alkenes (up to 1-decene) and 1-alkanols (up to 1-undecanol). These data follow the same decreasing trend with the molecular weight as n-alkanes. This trend is not in agreement with the predictions of most group-contribution methods...

  7. Corneal endothelial cell density and morphology in healthy Turkish eyes.

    Science.gov (United States)

    Arıcı, Ceyhun; Arslan, Osman Sevki; Dikkaya, Funda

    2014-01-01

    Purpose. To describe the normative values of corneal endothelial cell density, morphology, and central corneal thickness in healthy Turkish eyes. Methods. Specular microscopy was performed in 252 eyes of 126 healthy volunteers (M : F, 42 : 84). Parameters studied included mean endothelial cell density (MCD), mean cell area (MCA), coefficient of variation (CV) in cell size, percentage of hexagonal cells, and central corneal thickness (CCT). Results. The mean age of volunteers was 44.3 ± 13.5 (range, 20 to 70) years. There was a statistically significant decrease in MCD (P Filipino eyes and higher than that described in Indian, Thai, and Iranian eyes.

  8. The significance of HIV to bone mineral density

    DEFF Research Database (Denmark)

    Wessman, Maria; Weis, Nina; Katzenstein, Terese L

    2017-01-01

    The life expectancy in well-treated HIV-infected persons approaches that of the general population, but HIV-infected persons have a greater incidence of fractures and osteoporosis. A decrease in bone mineral density is observed primarily during the first 1-2 years of antiretroviral therapy. Dual X......-ray absorptiometry scan should be considered in HIV-infected men ≥ 50 years and postmenopausal women. In case of osteoporosis, bisphosphonate treatment should follow guidelines for the general population. Future research should focus on pathogenesis and prevention of bone density loss in HIV....

  9. Analysis of defect structure in silicon. Effect of grain boundary density on carrier mobility in UCP material

    Science.gov (United States)

    Dunn, J.; Stringfellow, G. B.; Natesh, R.

    1982-01-01

    The relationships between hole mobility and grain boundary density were studied. Mobility was measured using the van der Pauw technique, and grain boundary density was measured using a quantitative microscopy technique. Mobility was found to decrease with increasing grain boundary density.

  10. Effect of graphite target power density on tribological properties of graphite-like carbon films

    Science.gov (United States)

    Dong, Dan; Jiang, Bailing; Li, Hongtao; Du, Yuzhou; Yang, Chao

    2018-05-01

    In order to improve the tribological performance, a series of graphite-like carbon (GLC) films with different graphite target power densities were prepared by magnetron sputtering. The valence bond and microstructure of films were characterized by AFM, TEM, XPS and Raman spectra. The variation of mechanical and tribological properties with graphite target power density was analyzed. The results showed that with the increase of graphite target power density, the deposition rate and the ratio of sp2 bond increased obviously. The hardness firstly increased and then decreased with the increase of graphite target power density, whilst the friction coefficient and the specific wear rate increased slightly after a decrease with the increasing graphite target power density. The friction coefficient and the specific wear rate were the lowest when the graphite target power density was 23.3 W/cm2.

  11. Correlations between insulin sensitivity and bone mineral density in non-diabetic men

    DEFF Research Database (Denmark)

    Abrahamsen, B.; Rohold, A.; Henriksen, Jan Erik

    2000-01-01

    AIMS: To investigate relationships between bone mineral density (BMD), insulin secretion and insulin sensitivity, controlling for body composition, in view of data suggesting that hyperglycaemia [corrected] leads to decreased osteoblast proliferation and a negative calcium balance and that insulin...

  12. The decrease of mineralcorticoid receptor drives angiogenic pathways in colorectal cancer.

    Directory of Open Access Journals (Sweden)

    Laura Tiberio

    Full Text Available Angiogenesis plays a crucial role in tumor growth and progression. Low expression of mineralocorticoid receptor (MR in several malignant tumors correlates with disease recurrence and overall survival. Previous studies have shown that MR expression is decreased in colorectal cancer (CRC. Here we hypothesize that decreased MR expression can contribute to angiogenesis and poor patient survival in colorectal malignancies. In a cohort of CRC patients, we analyzed tumor MR expression, its correlation with tumor microvascular density and its impact on survival. Subsequently, we interrogated the role of MR in angiogenesis in an in vitro model, based on the colon cancer cell line HCT116, ingenierized to re-express a physiologically controlled MR. In CRC, decreased MR expression was associated with increased microvascular density and poor patient survival. In pchMR transfected HCT116, aldosterone or natural serum steroids largely inhibited mRNA expression levels of both VEGFA and its receptor 2/KDR. In CRC, MR activation may significantly decrease angiogenesis by directly inhibiting dysregulated VEGFA and hypoxia-induced VEGFA mRNA expression. In addition, MR activation attenuates the expression of the VEGF receptor 2/KDR, possibly dampening the activation of a VEGFA/KDR dependent signaling pathway important for the survival of tumor cells under hypoxic conditions.

  13. Decreasing transobturator sling groin pain without decreasing efficacy using TVT-Abbrevo.

    Science.gov (United States)

    Shaw, Jonathan S; Jeppson, Peter C; Rardin, Charles R

    2015-09-01

    Groin pain following a transobturator (TO) midurethral sling is not uncommon and can be difficult to manage. We sought to determine if decreasing the mesh burden in the groin would decrease pain. The primary objective was to compare the incidence of post-operative groin pain following placement of full-length TVT-Obturator versus the shorter TVT-Abbrevo. Secondarily, we aimed to compare the efficacy between both devices 6 months after surgery. This is a retrospective cohort study of all women who underwent a TO midurethral sling by the division of urogynecology at one institution between 1 January 2007 and 31 October 2013. Charts were reviewed and the incidence of post-operative groin pain in the two groups dichotomized as present or absent and compared using a Chi-squared test. Validated questionnaire scores of the groups were compared using t tests. There were 125 patients who received a TVT-Obturator and 100 patients who received a TVT-Abbrevo. No differences in demographic data were present between the groups. Twelve patients (9.6 %) in the TVT-Obturator group and 1 patient (1 %) in the TVT-Abbrevo group experienced bothersome groin pain (P value = 0.007). The complete pre- and 6-month post-operative ISI, UDI-6 and PFIQ-7 scores were available for 76 (61 %), 47 (38 %), and 45 (36 %) patients following TVT-Obturator and 57 (57 %), 30 (30 %), and 28 (28 %) following TVT-Abbrevo treatment. At 6 months the mean improvement in questionnaire scores for the TVT-Obturator and TVT-Abbrevo groups were as follows: 5.0 and 5.1 for ISI (P value = 0.9), 8.3 and 7.9 for UDI-6 (P value = 0.8), and 4.8 and 6.1 for PFIQ-7 (P value = 0.4). Use of TVT-Abbrevo reduces post-operative groin pain compared with the full-length TVT-Obturator, without any reduction in efficacy.

  14. Mammographic density changes following discontinuation of tamoxifen in premenopausal women with oestrogen receptor-positive breast cancer.

    Science.gov (United States)

    Kim, Won Hwa; Cho, Nariya; Kim, Young-Seon; Yi, Ann

    2018-04-06

    To evaluate the changes in mammographic density after tamoxifen discontinuation in premenopausal women with oestrogen receptor-positive breast cancers and the underlying factors METHODS: A total of 213 consecutive premenopausal women with breast cancer who received tamoxifen treatment after curative surgery and underwent three mammograms (baseline, after tamoxifen treatment, after tamoxifen discontinuation) were included. Changes in mammographic density after tamoxifen discontinuation were assessed qualitatively (decrease, no change, or increase) by two readers and measured quantitatively by semi-automated software. The association between % density change and clinicopathological factors was evaluated using univariate and multivariate regression analyses. After tamoxifen discontinuation, a mammographic density increase was observed in 31.9% (68/213, reader 1) to 22.1% (47/213, reader 2) by qualitative assessment, with a mean density increase of 1.8% by quantitative assessment compared to density before tamoxifen discontinuation. In multivariate analysis, younger age (≤ 39 years) and greater % density decline after tamoxifen treatment (≥ 17.0%) were independent factors associated with density change after tamoxifen discontinuation (p density change with a mean density increase of 1.8%, which was associated with younger age and greater density change after tamoxifen treatment. • Increased mammographic density after tamoxifen discontinuation can occur in premenopausal women. • Mean density increase after tamoxifen discontinuation was 1.8%. • Density increase is associated with age and density decrease after tamoxifen.

  15. Atmospheric density determination using high-accuracy satellite GPS data

    Science.gov (United States)

    Tingling, R.; Miao, J.; Liu, S.

    2017-12-01

    Atmospheric drag is the main error source in the orbit determination and prediction of low Earth orbit (LEO) satellites, however, empirical models which are used to account for atmosphere often exhibit density errors around 15 30%. Atmospheric density determination thus become an important topic for atmospheric researchers. Based on the relation between atmospheric drag force and the decay of orbit semi-major axis, we derived atmospheric density along the trajectory of CHAMP with its Rapid Science Orbit (RSO) data. Three primary parameters are calculated, including the ratio of cross sectional area to mass, drag coefficient, and the decay of semi-major axis caused by atmospheric drag. We also analyzed the source of error and made a comparison between GPS-derived and reference density. Result on 2 Dec 2008 shows that the mean error of GPS-derived density can decrease from 29.21% to 9.20% when time span adopted on the process of computation increase from 10min to 50min. Result for the whole December indicates that when the time span meet the condition that the amplitude of the decay of semi-major axis is much greater than its standard deviation, then density precision of 10% can be achieved.

  16. Roles of pinning strength and density in vortex melting

    International Nuclear Information System (INIS)

    Obaidat, I M; Khawaja, U Al; Benkraouda, M

    2008-01-01

    We have investigated the role of pinning strength and density on the equilibrium vortex-lattice to vortex-liquid phase transition under several applied magnetic fields. This study was conducted using a series of molecular dynamic simulations on several samples with different strengths and densities of pinning sites which are arranged in periodic square arrays. We have found a single solid-liquid vortex transition when the vortex filling factor n>1. We have found that, for fixed pinning densities and strengths, the melting temperature, T m , decreases almost linearly with increasing magnetic field. Our results provide direct numerical evidence for the significant role of both the strength and density of pinning centers on the position of the melting line. We have found that the vortex-lattice to vortex-liquid melting line shifts up as the pinning strength or the pinning density was increased. The effect on the melting line was found to be more pronounced at small values of strength and density of pinning sites

  17. Mineralogia de um argissolo vermelho-amarelo eutrófico e de um planossolo háplico eutrófico solódico numa toposseqüência de gnaisse no Sertão Central do Ceará

    Directory of Open Access Journals (Sweden)

    F. O. B. Mota

    2002-09-01

    Full Text Available Propriedades morfológicas, físicas e químicas, mineralogia e transformações mineralógicas foram investigadas num Argissolo Vermelho - Amarelo eutrófico (bem drenado e num Planossolo Háplico eutrófico solódico (imperfeitamente drenado, originados de gnaisse, numa toposseqüência no Sertão Central do Ceará. O trabalho teve o propósito de avaliar a influência da posição dos solos na paisagem (drenagem interna e na diversificação de suas propriedades, bem como estudar a ação de processos superficiais de transporte e deposição na homogeneidade do material originário. A areia e o silte grosso foram analisados por microscopia de polarização e contraste de fase, e o silte fino e a argila, por difração de raios-X. A microscopia eletrônica de varredura foi também utilizada com o objetivo de fornecer informações complementares sobre as alterações mineralógicas ocorridas. As frações areia e silte grosso apresentaram no Argissolo Vermelho-Amarelo eutrófico (PVAe grande teor de biotita e no Planossolo Háplico Eutrófico solódico (SXen, biotita e hornblenda com considerável redução dos horizontes inferiores em direção à superfície. Quartzo e plagioclásios foram também encontrados nessas frações em ambos os solos. Na fração argila do PVAe, dominam caulinita e vermiculita, ocorrendo também quartzo, e no silte fino, a caulinita é dominante com ocorrência de teores variáveis de biotita, plagioclásios e quartzo. No Sxen, a fração mais fina é dominada por caulinita e montmorilonita, ocorrendo ainda, em alguns horizontes, quartzo e um mineral interestratificado regular de 2,4 nm (vermiculita + mica. No silte fino, além da ocorrência dos minerais primários supracitados, verificou-se a presença de caulinita, ilita, vermiculita, montmorilonita e do mineral interestratificado, com teores variáveis de horizonte para horizonte. A drenagem interna de cada solo propiciou condições diferentes para as

  18. Experimental effects of herbivore density on above-ground plant biomass in an alpine grassland ecosystem

    OpenAIRE

    Austrheim, Gunnar; Speed, James David Mervyn; Martinsen, Vegard; Mulder, Jan; Mysterud, Atle

    2014-01-01

    Herbivores may increase or decrease aboveground plant productivity depending on factors such as herbivore density and habitat productivity. The grazing optimization hypothesis predicts a peak in plant production at intermediate herbivore densities, but has rarely been tested experimentally in an alpine field setting. In an experimental design with three densities of sheep (high, low, and no sheep), we harvested aboveground plant biomass in alpine grasslands prior to treatment and after five y...

  19. Density of Liquid Steel over Temperature Range of 1 803-1 873 K

    Institute of Scientific and Technical Information of China (English)

    XIAO Feng; FANG Liang

    2004-01-01

    The density of three kinds of liquid steel was measured by a modified sessile drop method over the temperature range of 1 803-1 873 K. It is found that the density of liquid steels decreases with increasing temperature and carbon content in steel. Both of the density and its absolute temperature coefficient of studied steels are smaller than the literature values of pure iron. The molar volume of the steels increases with increasing temperature.

  20. What causes the density effect in young forest plantations?; FINAL

    International Nuclear Information System (INIS)

    Barbara J. Bond; Gary A. Ritchie

    2002-01-01

    boundary layer conductance in young stands, it does not account for the ''density effect''. Our tests of the light quality hypothesis were slowed due to poor plantation establishment in the early phase of this study. In a variable density experiment we detected significant changes in R:FR related to density. Also in that study we measured a significant enhancement of tree height at high density. However, after three years of growth, the study trees did not show significant differences in stem diameter related to density. Experimenters at Weyerhaeuser therefore decided not to harvest the trees at the end of the 3rd growth year, as originally planned. In a 1-year study of seedlings planted in raised beds subjected to different light quality treatments using transparent plastic film, we found that tree height but not diameter increased in response to decreased R:FR. At this point, we conclude that R:FR remains a viable hypothesis for the ''density effect'', but evidence is not conclusive. We expect that continued measurements in the variable density test plot at Weyerhaeuser will add more evidence in the future

  1. Deforestation and rainfall recycling in Brazil: Is decreased forest cover connectivity associated with decreased rainfall connectivity?

    Science.gov (United States)

    Adera, S.; Larsen, L.; Levy, M. C.; Thompson, S. E.

    2017-12-01

    In the Brazilian rainforest-savanna transition zone, deforestation has the potential to significantly affect rainfall by disrupting rainfall recycling, the process by which regional evapotranspiration contributes to regional rainfall. Understanding rainfall recycling in this region is important not only for sustaining Amazon and Cerrado ecosystems, but also for cattle ranching, agriculture, hydropower generation, and drinking water management. Simulations in previous studies suggest complex, scale-dependent interactions between forest cover connectivity and rainfall. For example, the size and distribution of deforested patches has been found to affect rainfall quantity and spatial distribution. Here we take an empirical approach, using the spatial connectivity of rainfall as an indicator of rainfall recycling, to ask: as forest cover connectivity decreased from 1981 - 2015, how did the spatial connectivity of rainfall change in the Brazilian rainforest-savanna transition zone? We use satellite forest cover and rainfall data covering this period of intensive forest cover loss in the region (forest cover from the Hansen Global Forest Change dataset; rainfall from the Climate Hazards Infrared Precipitation with Stations dataset). Rainfall spatial connectivity is quantified using transfer entropy, a metric from information theory, and summarized using network statistics. Networks of connectivity are quantified for paired deforested and non-deforested regions before deforestation (1981-1995) and during/after deforestation (2001-2015). Analyses reveal a decline in spatial connectivity networks of rainfall following deforestation.

  2. Double trouble at high density:

    DEFF Research Database (Denmark)

    Gergs, André; Palmqvist, Annemette; Preuss, Thomas G

    2014-01-01

    Population size is often regulated by negative feedback between population density and individual fitness. At high population densities, animals run into double trouble: they might concurrently suffer from overexploitation of resources and also from negative interference among individuals...... regardless of resource availability, referred to as crowding. Animals are able to adapt to resource shortages by exhibiting a repertoire of life history and physiological plasticities. In addition to resource-related plasticity, crowding might lead to reduced fitness, with consequences for individual life...... history. We explored how different mechanisms behind resource-related plasticity and crowding-related fitness act independently or together, using the water flea Daphnia magna as a case study. For testing hypotheses related to mechanisms of plasticity and crowding stress across different biological levels...

  3. Generalized Expression for Polarization Density

    International Nuclear Information System (INIS)

    Wang, Lu; Hahm, T.S.

    2009-01-01

    A general polarization density which consists of classical and neoclassical parts is systematically derived via modern gyrokinetics and bounce-kinetics by employing a phase-space Lagrangian Lie-transform perturbation method. The origins of polarization density are further elucidated. Extending the work on neoclassical polarization for long wavelength compared to ion banana width [M. N. Rosenbluth and F. L. Hinton, Phys. Rev. Lett. 80, 724 (1998)], an analytical formula for the generalized neoclassical polarization including both finite-banana-width (FBW) and finite-Larmor-radius (FLR) effects for arbitrary radial wavelength in comparison to banana width and gyroradius is derived. In additional to the contribution from trapped particles, the contribution of passing particles to the neoclassical polarization is also explicitly calculated. Our analytic expression agrees very well with the previous numerical results for a wide range of radial wavelength.

  4. Asymptotic density and effective negligibility

    Science.gov (United States)

    Astor, Eric P.

    In this thesis, we join the study of asymptotic computability, a project attempting to capture the idea that an algorithm might work correctly in all but a vanishing fraction of cases. In collaboration with Hirschfeldt and Jockusch, broadening the original investigation of Jockusch and Schupp, we introduce dense computation, the weakest notion of asymptotic computability (requiring only that the correct answer is produced on a set of density 1), and effective dense computation, where every computation halts with either the correct answer or (on a set of density 0) a symbol denoting uncertainty. A few results make more precise the relationship between these notions and work already done with Jockusch and Schupp's original definitions of coarse and generic computability. For all four types of asymptotic computation, including generic computation, we demonstrate that non-trivial upper cones have measure 0, building on recent work of Hirschfeldt, Jockusch, Kuyper, and Schupp in which they establish this for coarse computation. Their result transfers to yield a minimal pair for relative coarse computation; we generalize their method and extract a similar result for relative dense computation (and thus for its corresponding reducibility). However, all of these notions of near-computation treat a set as negligible iff it has asymptotic density 0. Noting that this definition is not computably invariant, this produces some failures of intuition and a break with standard expectations in computability theory. For instance, as shown by Hamkins and Miasnikov, the halting problem is (in some formulations) effectively densely computable, even in polynomial time---yet this result appears fragile, as indicated by Rybalov. In independent work, we respond to this by strengthening the approach of Jockusch and Schupp to avoid such phenomena; specifically, we introduce a new notion of intrinsic asymptotic density, invariant under computable permutation, with rich relations to both

  5. High density energy storage capacitor

    International Nuclear Information System (INIS)

    Whitham, K.; Howland, M.M.; Hutzler, J.R.

    1979-01-01

    The Nova laser system will use 130 MJ of capacitive energy storage and have a peak power capability of 250,000 MW. This capacitor bank is a significant portion of the laser cost and requires a large portion of the physical facilities. In order to reduce the cost and volume required by the bank, the Laser Fusion Program funded contracts with three energy storage capacitor producers: Aerovox, G.E., and Maxwell Laboratories, to develop higher energy density, lower cost energy storage capacitors. This paper describes the designs which resulted from the Aerovox development contract, and specifically addresses the design and initial life testing of a 12.5 kJ, 22 kV capacitor with a density of 4.2 J/in 3 and a projected cost in the range of 5 cents per joule

  6. Density Gradient Stabilization of Electron Temperature Gradient Driven Turbulence in a Spherical Tokamak

    International Nuclear Information System (INIS)

    Ren, Y.; Kaye, S.M.; Mazzucato, E.; Guttenfelder, W.; Bell, R.E.; Domier, C.W.; LeBlanc, B.P.; Lee, K.C.; Luhmann, N.C. Jr.; Smith, D.R.; Yuh, H.

    2011-01-01

    In this letter we report the first clear experimental observation of density gradient stabilization of electron temperature gradient driven turbulence in a fusion plasma. It is observed that longer wavelength modes, k (perpendicular) ρ s ∼< 10, are most stabilized by density gradient, and the stabilization is accompanied by about a factor of two decrease in the plasma effective thermal diffusivity.

  7. Effect of root density on erosion and erodibility of a loamy soil under simulated rain

    DEFF Research Database (Denmark)

    Katuwal, Sheela; Vermang, J.; Cornelis, W. M.

    2013-01-01

    of complete plants and (2) after clipping off the shoots. Roots of ryegrass grew rapidly, attaining densities of 0.614 kg m−2 and 2.280 kg m−2 in 4 and 12 weeks respectively. There was no significant influence of root density alone in runoff whereas presence of shoots decreased runoff over control...

  8. Density operators in quantum mechanics

    International Nuclear Information System (INIS)

    Burzynski, A.

    1979-01-01

    A brief discussion and resume of density operator formalism in the way it occurs in modern physics (in quantum optics, quantum statistical physics, quantum theory of radiation) is presented. Particularly we emphasize the projection operator method, application of spectral theorems and superoperators formalism in operator Hilbert spaces (Hilbert-Schmidt type). The paper includes an appendix on direct sums and direct products of spaces and operators, and problems of reducibility for operator class by using the projection operators. (author)

  9. On the kinetic energy density

    International Nuclear Information System (INIS)

    Lombard, R.J.; Mas, D.; Moszkowski, S.A.

    1991-01-01

    We discuss two expressions for the density of kinetic energy which differ by an integration by parts. Using the Wigner transform we shown that the arithmetic mean of these two terms is closely analogous to the classical value. Harmonic oscillator wavefunctions are used to illustrate the radial dependence of these expressions. We study the differences they induce through effective mass terms when performing self-consistent calculations. (author)

  10. Neutronic density perturbation by probes

    International Nuclear Information System (INIS)

    Vigon, M. A.; Diez, L.

    1956-01-01

    The introduction of absorbent materials of neutrons in diffuser media, produces local disturbances of neutronic density. The disturbance depends especially on the nature and size of the absorbent. Approximated equations which relates te disturbance and the distance to the absorbent in the case of thin disks have been drawn. The experimental comprobation has been carried out in two especial cases. In both cases the experimental results are in agreement with the calculated values from these equations. (Author)

  11. Ion density in ionizing beams

    International Nuclear Information System (INIS)

    Knuyt, G.K.; Callebaut, D.K.

    1978-01-01

    The equations defining the ion density in a non-quasineutral plasma (chasma) are derived for a number of particular cases from the general results obtained in paper 1. Explicit calculations are made for a fairly general class of boundaries: all tri-axial ellipsoids, including cylinders with elliptic cross-section and the plane parallel case. The results are very simple. When the ion production and the beam intensity are constant then the steady state ion space charge is also constant in space, it varies over less than 10% for the various geometries, it may exceed the beam density largely for comparatively high pressures (usually still less than about 10 -3 Torr), it is tabulated for a number of interesting cases and moreover it can be calculated precisely and easily by some simple formulae for which also approximations are elaborated. The total potential is U =-ax 2 -by 2 -cz 2 , a, b and c constants which can be calculated immediately from the space charge density and the geometry; the largest coefficient varies at most over a factor four for various geometries; it is tabulated for a number of interesting cases. (author)

  12. Density functional theory of nuclei

    International Nuclear Information System (INIS)

    Terasaki, Jun

    2008-01-01

    The density functional theory of nuclei has come to draw attention of scientists in the field of nuclear structure because the theory is expected to provide reliable numerical data in wide range on the nuclear chart. This article is organized to present an overview of the theory to the people engaged in the theory of other fields as well as those people in the nuclear physics experiments. At first, the outline of the density functional theory widely used in the electronic systems (condensed matter, atoms, and molecules) was described starting from the Kohn-Sham equation derived on the variational principle. Then the theory used in the field of nuclear physics was presented. Hartree-Fock and Hartree-Fock-Bogolyubov approximation by using Skyrme interaction was explained. Comparison of the results of calculations and experiments of binding energies and ground state mean square charge radii of some magic number nuclei were shown. The similarity and dissimilarity between the two streams were summarized. Finally the activities of the international project of Universal Nuclear Energy Density Functional (UNEDF) which was started recently lead by US scientist was reported. This project is programmed for five years. One of the applications of the project is the calculation of the neutron capture cross section of nuclei on the r-process, which is absolutely necessary for the nucleosynthesis research. (S. Funahashi)

  13. Dual chiral density wave in quark matter

    International Nuclear Information System (INIS)

    Tatsumi, Toshitaka

    2002-01-01

    We prove that quark matter is unstable for forming a dual chiral density wave above a critical density, within the Nambu-Jona-Lasinio model. Presence of a dual chiral density wave leads to a uniform ferromagnetism in quark matter. A similarity with the spin density wave theory in electron gas and the pion condensation theory is also pointed out. (author)

  14. Density functionals in the laboratory frame

    International Nuclear Information System (INIS)

    Giraud, B. G.

    2008-01-01

    We compare several definitions of the density of a self-bound system, such as a nucleus, in relation with its center-of-mass zero-point motion. A trivial deconvolution relates the internal density to the density defined in the laboratory frame. This result is useful for the practical definition of density functionals

  15. On VC-density over indiscernible sequences

    OpenAIRE

    Guingona, Vincent; Hill, Cameron Donnay

    2011-01-01

    In this paper, we study VC-density over indiscernible sequences (denoted VC_ind-density). We answer an open question in [1], showing that VC_ind-density is always integer valued. We also show that VC_ind-density and dp-rank coincide in the natural way.

  16. Liver lipase and high-density lipoprotein. Lipoprotein changes after incubation of human serum with rat liver lipase.

    Science.gov (United States)

    Groot, P H; Scheek, L M; Jansen, H

    1983-05-16

    Human sera were incubated with rat liver lipase after inactivation of lecithin:cholesterol acyltransferase, and the changes in serum lipoprotein composition were measured. In the presence of liver lipase serum triacylglycerol and phosphatidylcholine were hydrolyzed. The main changes in the concentrations of these lipids were found in the high-density lipoprotein fraction. Subfractionation of high-density lipoprotein by rate-zonal ultracentrifugation showed a prominent decrease in all constituents of high-density lipoprotein2, a smaller decrease in the 'light' high-density lipoprotein3 and an increase in the 'heavy' high-density lipoprotein3. These data support a concept in which liver lipase is involved in high-density lipoprotein2 phospholipid and triacylglycerol catabolism and suggest that as a result of this action high-density lipoprotein2 is converted into high-density lipoprotein3.

  17. Research of mechanism of density lock

    International Nuclear Information System (INIS)

    Wang Shengfei; Yan Changqi; Gu Haifeng

    2010-01-01

    Mechanism of density lock was analyzed according to the work conditions of density lock. The results showed that: the stratification with no disturbance satisfied the work conditions of density lock; fluids between the stratification were not mixed at the condition of connected to each other; the density lock can be open automatically by controlled the pressure balance at the stratification. When disturbance existed, the stratification might be broken and mass would be transferred by convection. The stability of stratification can be enhanced by put the special structure in density lock to ensure the normal work of density lock. At last, the minimum of heat loss in density lock was also analyzed. (authors)

  18. Characterization of forced response of density stratified reacting wake

    Science.gov (United States)

    Pawar, Samadhan A.; Sujith, Raman I.; Emerson, Benjamin; Lieuwen, Tim

    2018-02-01

    The hydrodynamic stability of a reacting wake depends primarily on the density ratio [i.e., ratio of unburnt gas density (ρu) to burnt gas density (ρb)] of the flow across the wake. The variation of the density ratio from high to low value, keeping ρ u / ρ b > 1 , transitions dynamical characteristics of the reacting wake from a linearly globally stable (or convectively unstable) to a globally unstable mode. In this paper, we propose a framework to analyze the effect of harmonic forcing on the deterministic and synchronization characteristics of reacting wakes. Using the recurrence quantification analysis of the forced wake response, we show that the deterministic behaviour of the reacting wake increases as the amplitude of forcing is increased. Furthermore, for different density ratios, we found that the synchronization of the top and bottom branches of the wake with the forcing signal is dependent on whether the mean frequency of the natural oscillations of the wake (fn) is lesser or greater than the frequency of external forcing (ff). We notice that the response of both branches (top and bottom) of the reacting wake to the external forcing is asymmetric and symmetric for the low and high density ratios, respectively. Furthermore, we characterize the phase-locking behaviour between the top and bottom branches of the wake for different values of density ratios. We observe that an increase in the density ratio results in a gradual decrease in the relative phase angle between the top and bottom branches of the wake, which leads to a change in the vortex shedding pattern from a sinuous (anti-phase) to a varicose (in-phase) mode of the oscillations.

  19. Rapid fall in lung density following smoking cessation in COPD.

    Science.gov (United States)

    Shaker, Saher B; Stavngaard, Trine; Laursen, Lars Christian; Stoel, Berend C; Dirksen, Asger

    2011-02-01

    Whether smoking-induced lung inflammation subsides after smoking cessation is currently a matter of debate. We used computed tomography (CT) to evaluate the effect of smoking cessation on lung density in patients with COPD. Thirty-six patients quit smoking out of 254 current smokers with COPD who were followed with annual CT and lung function tests (LFT) for 2?4 years as part of a randomised placebo-controlled trial of the effect of inhaled budesonide on CT-lung density. Lung density was expressed as the 15th percentile density (PD15) and relative area of emphysema below -910 HU (RA-910). From the time-trends in the budesonide and placebo groups the expected CT-lung densities at the first visit after smoking cessation were calculated by linear regression and compared to the observed densities. Following smoking cessation RA-910 increased by 2.6% (p = 0.003) and PD15 decreased by -4.9 HU (p = 0.0002). Furthermore, changes were larger in the budesonide group than the placebo group (PD15: -7.1 vs -2.8 HU. RA-910 3.7% vs 1.7%). These differences were, however, not statistically significant. The LFT parameters (FEV(1) and diffusion capacity) were not significantly influenced by smoking cessation. Inflammation partly masks the presence of emphysema on CT and smoking cessation results in a paradoxical fall in lung density, which resembles rapid progression of emphysema. This fall in density is probably due to an anti-inflammatory effect of smoking cessation.

  20. Decrease in TSH Receptor Autoantibodies during Antithyroid Treatment

    DEFF Research Database (Denmark)

    Christensen, Niels Juel; Habekost, Gurli; Bratholm, Palle

    2011-01-01

    that TRAb decrease significantly during treatment with antithyroid drugs. This decrease during treatment cannot be explained by Heg RNA, which remains unchanged. Cdk1 mRNA decreased significantly during treatment to values below values obtained in normal subjects. Thus both Heg RNA and Cdk1 mRNA may...

  1. Plasma density profiles and finite bandwidth effects on electron heating

    International Nuclear Information System (INIS)

    Spielman, R.B.; Mizuno, K.; DeGroot, J.S.; Bollen, W.M.; Woo, W.

    1980-01-01

    Intense, p-polarized microwaves are incident on an inhomogeneous plasma in a cylindrical waveguide. Microwaves are mainly absorbed by resonant absorption near the critical surface (where the plasma frequency, ω/sub pe/, equals the microwave frequency, ω/sub o/). The localized plasma waves strongly modify the plasma density. Step-plateau density profiles or a cavity are created depending on the plasma flow speed. Hot electron production is strongly affected by the microwave bandwidth. The hot electron temperature varies as T/sub H/ is proportional to (Δ ω/ω) -0 25 . As the hot electron temperature decreases with increasing driver bandwidth, the hot electron density increases. This increase is such that the heat flux into the overdense region (Q is proportional to eta/sub H/T/sub H/ 3 2 ) is nearly constant

  2. X-ray electron density distribution of GaAs

    International Nuclear Information System (INIS)

    Pietsch, U.

    1986-01-01

    Using ten X-ray structure amplitudes of strong reflections and nine weak reflections both, the valence electron and the difference electron density distribution of GaAs, are calculated. The experimental data are corrected for anomalous dispersion using a bond charge model. The calculated plots are compared with up to now published band structure-based and semiempirically calculated density plots. Taking into account the experimental data of germanium, measured on the same absolute scale, the difference density between GaAs and Ge is calculated. This exhibits the charge transfer between both the f.c.c.-sublattices as well as both, the shift and the decrease of the bond charge, quite closely connected to the theoretical results published by Baur et al. (author)

  3. Stationary density profiles in the Alcator C-mod tokamak

    International Nuclear Information System (INIS)

    Kesner, J.; Ernst, D.; Hughes, J.; Mumgaard, R.; Shiraiwa, S.; Whyte, D.; Scott, S.

    2012-01-01

    In the absence of an internal particle source, plasma turbulence will impose an intrinsic relationship between an inwards pinch and an outwards diffusion resulting in a stationary density profile. The Alcator C-mod tokamak utilizes RF heating and current drive so that fueling only occurs in the vicinity of the separatrix. Discharges that transition from L-mode to I-mode are seen to maintain a self-similar stationary density profile as measured by Thomson scattering. For discharges with negative magnetic shear, an observed rise of the safety factor in the vicinity of the magnetic axis appears to be accompanied by a decrease of electron density, qualitatively consistent with the theoretical expectations.

  4. Bone mineral density and metabolic indices in hyperthyroidism.

    Science.gov (United States)

    Al-Nuaim, A; El-Desouki, M; Sulimani, R; Mohammadiah, M

    1991-09-01

    Hyperthyroidism can alter bone metabolism by increasing both bone resorption and formation. The increase in bone resorption predominates, leading to a decrease in bone mass. To assess the effect of hyperthyroidism on bone and mineral metabolism, we measured bone density using single photon absorptiometry in 30 untreated hyperthyroid patients. Patients were categorized into three groups based on sex and alkaline phosphatase levels: 44 sex- and age-matched subjects were used as controls. Bone densities were significanlty lower in all patient groups compared with controls. Alkaline phosphatase was found to be a useful marker for assessing severity of bone disease in hyperthyroid patients as there is significant bone density among patients with higher alkaline phosphatase value. Hyperthyroidism should be considered in the differential diagnosis of unexplained alkaline phophatase activity.

  5. Subacute stress and chronic stress interact to decrease intestinal barrier function in rats.

    Science.gov (United States)

    Lauffer, Adriana; Vanuytsel, Tim; Vanormelingen, Christophe; Vanheel, Hanne; Salim Rasoel, Shadea; Tóth, Joran; Tack, Jan; Fornari, Fernando; Farré, Ricard

    2016-01-01

    Psychological stress increases intestinal permeability, potentially leading to low-grade inflammation and symptoms in functional gastrointestinal disorders. We assessed the effect of subacute, chronic and combined stress on intestinal barrier function and mast cell density. Male Wistar rats were allocated to four experimental groups (n = 8/group): 1/sham; 2/subacute stress (isolation and limited movement for 24 h); 3/chronic crowding stress for 14 days and 4/combined subacute and chronic stress. Jejunum and colon were collected to measure: transepithelial electrical resistance (TEER; a measure of epithelial barrier function); gene expression of tight junction molecules; mast cell density. Plasma corticosterone concentration was increased in all three stress conditions versus sham, with highest concentrations in the combined stress condition. TEER in the jejunum was decreased in all stress conditions, but was significantly lower in the combined stress condition than in the other groups. TEER in the jejunum correlated negatively with corticosterone concentration. Increased expression of claudin 1, 5 and 8, occludin and zonula occludens 1 mRNAs was detected after subacute stress in the jejunum. In contrast, colonic TEER was decreased only after combined stress, and the expression of tight junction molecules was unaltered. Increased mast cell density was observed in the chronic and combined stress condition in the colon only. In conclusion, our data show that chronic stress sensitizes the gastrointestinal tract to the effects of subacute stress on intestinal barrier function; different underlying cellular and molecular alterations are indicated in the small intestine versus the colon.

  6. High-dose ascorbic acid decreases cholesterolemic factors of an atherogenic diet in guinea pigs.

    Science.gov (United States)

    Filis, Konstantinos; Anastassopoulou, Aikaterini; Sigala, Fragiska; Theodorou, Dimitrios; Manouras, Andreas; Leandros, Emanouel; Sigalas, Panagiotis; Hepp, Wolfgang; Bramis, John

    2007-03-01

    The study evaluates the effect of a high supplemental dose of ascorbic acid (AA) on plasma concentrations of total cholesterol (TC), triglycerides (TG), total lipids (TL), and lipoprotein fractions high-density, very-low-density-, and low-density lipoprotein (HDL, VLDL, LDL) in guinea pigs fed with atherogenic diet. Group I consisted of 5 normally fed guinea pigs plus a low dose of AA (1 mg/100 g/day), group II consisted of 7 guinea pigs fed with food enriched with 2% cholesterol plus a low dose of AA (1 mg/100 g/day), and group III consisted of 7 guinea pigs fed with food enriched with 2% cholesterol plus a high dose of AA (30 mg/100 g/day). Cholesterolemic factors concentrations were determined after nine weeks. Concentrations of TC, TG, TL, LDL, and VLDL were increased in group II compared to group I (p < 0.01 for all differences). Supplementation with a high dose of AA resulted in decreased concentrations of TC (p < 0.01), TG (p < 0.01), TL (p < 0.01), and LDL (p < 0.01) in group III compared to group II. Additionally, concentration of HDL was increased in group III compared to group II (p < 0.01). High-dose AA supplementation to an atherogenic diet decreases concentrations of TC, TG, TL, and LDL and increases concentration of HDL compared to low-dose AA.

  7. Analyzing the financial crisis using the entropy density function

    Science.gov (United States)

    Oh, Gabjin; Kim, Ho-yong; Ahn, Seok-Won; Kwak, Wooseop

    2015-02-01

    The risk that is created by nonlinear interactions among subjects in economic systems is assumed to increase during an abnormal state of a financial market. Nevertheless, investigating the systemic risk in financial markets following the global financial crisis is not sufficient. In this paper, we analyze the entropy density function in the return time series for several financial markets, such as the S&P500, KOSPI, and DAX indices, from October 2002 to December 2011 and analyze the variability in the entropy value over time. We find that the entropy density function of the S&P500 index during the subprime crisis exhibits a significant decrease compared to that in other periods, whereas the other markets, such as those in Germany and Korea, exhibit no significant decrease during the market crisis. These findings demonstrate that the S&P500 index generated a regular pattern in the return time series during the financial crisis.

  8. Feed intake as explanation for density related growth differences of common sole Solea solea

    DEFF Research Database (Denmark)

    Lund, Ivar; Steenfeldt, Svend Jørgen; Herrmann, Bent

    2013-01-01

    correlated to both fish size and individual SGR. Feed conversion ratio was likewise positively correlated to feed intake. The relative feed intake (g feed g fish−1) was not correlated to fish size at any density tested, but was significantly highest for the LD population. This explains a substantial part......Growth of common sole Solea solea is negatively correlated to density, which affects productivity in culture and hence commercial success. Studies of individual feed intake were performed to examine growth and population dynamics at different densities. Three initial stocking densities: 1.0, 2.......1 and 3.9 kg m−2 of individually tagged sole, referred to as low density (LD), medium density and high density HD), were examined during 145 days. Despite that tank productivity (g m−2 day−1), was highest for the HD group, the specific growth rate (SGR) decreased significantly with increase in stocking...

  9. Transversely driven charge density waves in NbSe3

    International Nuclear Information System (INIS)

    Markovic, N.; Dohmen, M.A.H.; Zant, H.S.J. van der

    1999-01-01

    We have studied the charge density wave (CDW) transport in the presence of a single-particle current flowing transversely to the sliding direction of the CDW. The depinning threshold field was found to decrease exponentially with the transverse current, allowing the CDWs to slide even at very low bias fields. The CDW transport is ohmic in this novel, nonequilibrium regime. The results from thin NbSe 3 crystals are in excellent agreement with recent theoretical predictions. (orig.)

  10. Prognostic Significance of Preterm Isolated Decreased Fetal Movement

    Directory of Open Access Journals (Sweden)

    Ertuğrul Karahanoğlu

    2017-12-01

    Full Text Available Objective: Our aim is to evaluate the prognostic significance of isolated, preterm decreased fetal movement following normal initial full diagnostic workup. Study design: A retrospective observational study was conducted at a tertiary centre. The applied protocol was approved by the Medical Research Ethics Department of the hospital where the research was conducted. Obstetrics outcomes of preterm- and term-decreased fetal movement were compared following an initial, normal diagnostic work up. Evaluated outcomes were birth weight, mode of delivery, stillbirth rate, induction of labour, development of gestational hypertension, small for gestational age and oligohydramnios, polyhydramnios during the follow up period. Result: Obstetric complications related to placental insufficiency develops more frequently for decreased fetal movement in preterm cases with respect to that of in term cases. Following the diagnosis of decreased fetal movement, pregnancy hypertension occurred in 17% of preterm decreased fetal movement cases and in 4.7% of term decreased fetal movement cases. Fetal growth restriction developed in 6.6% of preterm decreased fetal movement and in 2.3% of term decreased fetal movement. Amniotic fluid abnormalities more frequently developed in preterm decreased fetal movement. Conclusion: Following an initial normal diagnostic workup, preterm decreased fetal movement convey a higher risk for the development of pregnancy complications associated with placental insufficiency. The patient should be monitored closely and management protocols must be developed for initial normal diagnostic workups in cases of preterm decreased fetal movement.

  11. Mammographic Breast Density in Malaysian Women with Breast Cancer

    International Nuclear Information System (INIS)

    Noriah Jamal; Humairah Samad Cheung

    2016-01-01

    The objective of this study was to examine the mammographic breast density of women with breast cancer detected on voluntary mammographic screening at two selected screening centers in Malaysia. This was a retrospective study of Full-Field Digital Mammography (FFDM) images of 150 Malaysian women with biopsy-proven breast cancer. The study population comprised 73 Malays (37.7 %), 59 Chinese (39.3 %) and 18 Indians (12.0 %). The Tabar breast density Patterns (I - V) were used to evaluate mammographic breast density. Data were analyzed using descriptive statistics. The results were compared with findings from a similar study on a group of 668 women who did not have breast cancer. The results showed that 44.7 % of the study population had dense breasts (Patterns IV and V), 14.7 % had predominantly fatty breasts (Patterns II and III) while 40.7 % had Pattern I. The proportion of study population with dense breasts decreased with age. In conclusion, the proportion of women with dense breasts decreased with age. Majority of the women with cancer (44.7 %) had dense breasts of Tabar Patterns IV and V, which has been associated with increased risk of breast cancer detected by voluntary mammographic screening. The results support the notion that increased breast density is a risk factor of breast cancer. (author)

  12. How the climate limits the wood density of angiosperms

    Science.gov (United States)

    Choi, Jin Woo; Kim, Ho-Young

    2017-11-01

    Flowering trees have various types of wood structure to perform multiple functions under their environmental conditions. In addition to transporting water from the roots to the canopy and providing mechanical support, the structure should provide resistance to embolism to maintain soil-plant-atmosphere continuum. By investigating existing data of the resistivity to embolism and wood density of 165 angiosperm species, here we show that the climate can limit the intrinsic properties of trees. Trees living in the dry environments require a high wood density to slow down the pressure decrease as it loses water relatively fast by evaporation. However, building too much tissues will result in the decrease of hydraulic conductivity and moisture concentration around mesophyll cells. To rationalize the biologically observed lower bound of the wood density, we construct a mechanical model to predict the wood density as a function of the vulnerability to embolism and the time for the recovery. Also, we build an artificial system using hydrogel microchannels that can test the probability of embolism as a function of conduit distributions. Our theoretical prediction is shown to be consistent with the results obtained from the artificial system and the biological data.

  13. Minimal nuclear energy density functional

    Science.gov (United States)

    Bulgac, Aurel; Forbes, Michael McNeil; Jin, Shi; Perez, Rodrigo Navarro; Schunck, Nicolas

    2018-04-01

    We present a minimal nuclear energy density functional (NEDF) called "SeaLL1" that has the smallest number of possible phenomenological parameters to date. SeaLL1 is defined by seven significant phenomenological parameters, each related to a specific nuclear property. It describes the nuclear masses of even-even nuclei with a mean energy error of 0.97 MeV and a standard deviation of 1.46 MeV , two-neutron and two-proton separation energies with rms errors of 0.69 MeV and 0.59 MeV respectively, and the charge radii of 345 even-even nuclei with a mean error ɛr=0.022 fm and a standard deviation σr=0.025 fm . SeaLL1 incorporates constraints on the equation of state (EoS) of pure neutron matter from quantum Monte Carlo calculations with chiral effective field theory two-body (NN ) interactions at the next-to-next-to-next-to leading order (N3LO) level and three-body (NNN ) interactions at the next-to-next-to leading order (N2LO) level. Two of the seven parameters are related to the saturation density and the energy per particle of the homogeneous symmetric nuclear matter, one is related to the nuclear surface tension, two are related to the symmetry energy and its density dependence, one is related to the strength of the spin-orbit interaction, and one is the coupling constant of the pairing interaction. We identify additional phenomenological parameters that have little effect on ground-state properties but can be used to fine-tune features such as the Thomas-Reiche-Kuhn sum rule, the excitation energy of the giant dipole and Gamow-Teller resonances, the static dipole electric polarizability, and the neutron skin thickness.

  14. Estrogen induces rapid decrease in dendritic thorns of CA3 pyramidal neurons in adult male rat hippocampus

    International Nuclear Information System (INIS)

    Tsurugizawa, Tomokazu; Mukai, Hideo

    2005-01-01

    Modulation of hippocampal synaptic plasticity by estrogen has been attracting much attention. Thorns of thorny excrescences of CA3 hippocampal neurons are post-synaptic regions whose presynaptic partners are mossy fiber terminals. Here we demonstrated the rapid effect of estradiol on the density of thorns of thorny excrescences, by imaging Lucifer Yellow-injected CA3 neurons in adult male rat hippocampal slices. The application of 1 nM estradiol induced rapid decrease in the density of thorns on pyramidal neurons within 2 h. The estradiol-mediated decrease in the density of thorns was blocked by CNQX (AMPA receptor antagonist) and PD98059 (MAP kinase inhibitor), but not by MK-801 (NMDA receptor antagonist). ERα agonist PPT induced the same suppressive effect as that induced by estradiol on the density of thorns, but ERβ agonist DPN did not affect the density of thorns. Note that a 1 nM estradiol treatment did not affect the density of spines in the stratum radiatum and stratum oriens. A search for synaptic ERα was performed using purified RC-19 antibody. The localization of ERα (67 kDa) in the CA3 mossy fiber terminals and thorns was demonstrated using immunogold electron microscopy. These results imply that estradiol drives the signaling pathway including ERα and MAP kinase

  15. Bounded Densities and Their Derivatives

    DEFF Research Database (Denmark)

    Kozine, Igor; Krymsky, V.

    2009-01-01

    This paper describes how one can compute interval-valued statistical measures given limited information about the underlying distribution. The particular focus is on a bounded derivative of a probability density function and its combination with other available statistical evidence for computing ...... quantities of interest. To be able to utilise the evidence about the derivative it is suggested to adapt the ‘conventional’ problem statement to variational calculus and the way to do so is demonstrated. A number of examples are given throughout the paper....

  16. Equilibrium problems for Raney densities

    Science.gov (United States)

    Forrester, Peter J.; Liu, Dang-Zheng; Zinn-Justin, Paul

    2015-07-01

    The Raney numbers are a class of combinatorial numbers generalising the Fuss-Catalan numbers. They are indexed by a pair of positive real numbers (p, r) with p > 1 and 0 0 and similarly use both methods to identify the equilibrium problem for (p, r) = (θ/q + 1, 1/q), θ > 0 and q \\in Z+ . The Wiener-Hopf method is used to extend the latter to parameters (p, r) = (θ/q + 1, m + 1/q) for m a non-negative integer, and also to identify the equilibrium problem for a family of densities with moments given by certain binomial coefficients.

  17. High density fuel storage rack

    International Nuclear Information System (INIS)

    Zezza, L.J.

    1980-01-01

    High storage density for spent nuclear fuel assemblies in a pool achieved by positioning fuel storage cells of high thermal neutron absorption materials in an upright configuration in a rack. The rack holds the cells at required pitch. Each cell carries an internal fuel assembly support, and most cells are vertically movable in the rack so that they rest on the pool bottom. Pool water circulation through the cells and around the fuel assemblies is permitted by circulation openings at the top and bottom of the cells above and below the fuel assemblies

  18. Origin of cosmological density fluctuations

    International Nuclear Information System (INIS)

    Carr, B.J.

    1984-11-01

    The density fluctuations required to explain the large-scale cosmological structure may have arisen spontaneously as a result of a phase transition in the early Universe. There are several ways in which such fluctuations may have ben produced, and they could have a variety of spectra, so one should not necessarily expect all features of the large-scale structure to derive from a simple power law spectrum. Some features may even result from astrophysical amplification mechanisms rather than gravitational instability. 128 references

  19. Simvastatin decreases steroid production in the H295R cell line and decreases steroids and FSH in female rats

    DEFF Research Database (Denmark)

    Jensen, Anna Guldvang; Hansen, Cecilie Hurup; Weisser, Johan J

    2015-01-01

    .10-0.13μM for SV and from 0.019-0.055μM for SVA. In rats, SV decreased progestagens in ovaries, brain and plasma, and plasma FSH in the M (72.4% decrease) and H group (76.6% decrease). Because progestagens and gonadotropins are major players in fertility, administration of SV might exert negative effects...

  20. Comparison of three methods to reduce energy density: effects on daily energy intake

    OpenAIRE

    Williams, Rachel A.; Roe, Liane S.; Rolls, Barbara J.

    2013-01-01

    Reductions in food energy density can decrease energy intake, but it is not known if the effects depend on the way that energy density is reduced. We investigated whether three methods of reducing energy density (decreasing fat, increasing fruit and vegetables, and adding water) differed in their effects on energy intake across the day. In a crossover design, 59 adults ate breakfast, lunch, and dinner in the laboratory once a week for four weeks. Across conditions, the entrées were either sta...