WorldWideScience

Sample records for separation device development

  1. Development of on line automatic separation device for apple and sleeve

    Science.gov (United States)

    Xin, Dengke; Ning, Duo; Wang, Kangle; Han, Yuhang

    2018-04-01

    Based on STM32F407 single chip microcomputer as control core, automatic separation device of fruit sleeve is designed. This design consists of hardware and software. In hardware, it includes mechanical tooth separator and three degree of freedom manipulator, as well as industrial control computer, image data acquisition card, end effector and other structures. The software system is based on Visual C++ development environment, to achieve localization and recognition of fruit sleeve with the technology of image processing and machine vision, drive manipulator of foam net sets of capture, transfer, the designated position task. Test shows: The automatic separation device of the fruit sleeve has the advantages of quick response speed and high separation success rate, and can realize separation of the apple and plastic foam sleeve, and lays the foundation for further studying and realizing the application of the enterprise production line.

  2. A review on recent developments for biomolecule separation at analytical scale using microfluidic devices.

    Science.gov (United States)

    Tetala, Kishore K R; Vijayalakshmi, M A

    2016-02-04

    Microfluidic devices with their inherent advantages like the ability to handle 10(-9) to 10(-18) L volume, multiplexing of microchannels, rapid analysis and on-chip detection are proving to be efficient systems in various fields of life sciences. This review highlights articles published since 2010 that reports the use of microfluidic devices to separate biomolecules (DNA, RNA and proteins) using chromatography principles (size, charge, hydrophobicity and affinity) along with microchip capillary electrophoresis, isotachophoresis etc. A detailed overview of stationary phase materials and the approaches to incorporate them within the microchannels of microchips is provided as well as a brief overview of chemical methods to immobilize ligand(s). Furthermore, we review research articles that deal with microfluidic devices as analytical tools for biomolecule (DNA, RNA and protein) separation. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. Development of Multiscale Materials in Microfluidic Devices: Case Study for Viral Separation from Whole Blood

    Science.gov (United States)

    Surawathanawises, Krissada

    Separation and concentration of nanoscale species play an important role in various fields such as biotechnology, nanotechnology and environmental science. Inevitably, the separation efficiency strongly affects the quality of downstream detections or productions. Innovations in materials science that can separate bionanoparticles efficiently and do not require complex setups, reagents or external fields are highly demanded. This work focuses on developing new materials for the affinity separation of bio-nanoparticles such as viruses or macromolecules from a complex mixture, such as whole blood. To enhance the interaction between target nanoparticles and the capture bed, methods to produce porous matrices with a uniform pore size matching the dimension of targets are studied. Furthermore, regarding viral separation from whole blood, macroporous materials are further patterned into microarrays to allow multiscale separation. Considering the needs in resource-limited settings, these materials are integrated with microfluidic technologies to reduce the volume of samples and reagents, simplify operating processes, and enable the use of inexpensive and portable components. Beyond the application of viral separation as demonstrated in the work, the fundamental study of macroporous material formation and transport in these materials also shed light to the separation of many other nanospecies in multiscale materials. Specifically, two macroporous materials, based on template synthesis, are created in this work. The first type employs porous anodic aluminum oxide (AAO) films as the template to create hexagonal arrays of nanoposts. However, pore sizes and interpore distances (cell size) of ordered porous AAO films are limited by the conventional fabrication process. Moreover, the process usually yields defective pore morphologies and large pore and cell size distributions. To overcome these limitations, a patterning method using nanobead indentation on aluminum substrate

  4. Current Developments in Electrophoretic and Chromatographic Separation Methods on Microfabricated Devices

    DEFF Research Database (Denmark)

    Kutter, Jörg Peter

    2000-01-01

    Microchip-based separation techniques are essential elements in the development of fully integrated micro-total analysis systems, which are envisioned to become powerful instruments for obtaining and assessing analytical data in research, industry, and everyday life. This article's goal is to give...

  5. Photochemical separation and extraction device

    International Nuclear Information System (INIS)

    Wada, Yukio; Morimoto, Kyoichi.

    1998-01-01

    The present invention concerns a device for separating neptunium and plutonium from highly radioactive liquid wastes, in which valance control by irradiation of UV rays and extraction operation by using an organic solvent can be conducted simultaneously in the same reaction vessel. Namely, a step of irradiating UV rays to the liquid in the reaction vessel to control the valence of predetermined materials and a step of separating the materials by conducting solvent-extraction while stirring with a solvent are conducted simultaneously or successively. Then, facilities for the separation method can be reduced and the operation steps can be simplified. (N.H.)

  6. Waste classifying and separation device

    International Nuclear Information System (INIS)

    Kakiuchi, Hiroki.

    1997-01-01

    A flexible plastic bags containing solid wastes of indefinite shape is broken and the wastes are classified. The bag cutting-portion of the device has an ultrasonic-type or a heater-type cutting means, and the cutting means moves in parallel with the transferring direction of the plastic bags. A classification portion separates and discriminates the plastic bag from the contents and conducts classification while rotating a classification table. Accordingly, the plastic bag containing solids of indefinite shape can be broken and classification can be conducted efficiently and reliably. The device of the present invention has a simple structure which requires small installation space and enables easy maintenance. (T.M.)

  7. Optimization of the radio lanthanides separation device

    International Nuclear Information System (INIS)

    Vera T, A. L.

    2009-01-01

    At present, cancer is a major cause of mortality in our country, therefore, its prevention, diagnosis and treatment are vital to health systems. The cancer treatment and other diseases, from monoclonal antibodies, peptides, or amino macro aggregates marked with beta particle emitting radionuclides, is a highly promising field. The radioactive lanthanides: Pm, Tb, Ho, and Lu are beta emitters, which possess nuclear and chemical properties, which have shown their feasibility as radioisotopes of radiotherapeutic use. However, these radioisotopes are not available commercially in this connection, the Research Laboratory of Radioactive Materials of the National Institute of Nuclear Research, has developed the methodology of production of these radioisotopes and based on this work is designed, constructed and installed the radio lanthanides separation device for the radioisotopes production routinely. This device is part of the cell, , which has and auxiliary air service, an extraction system and is protected with a 10 cm of lead shielding. The radio lanthanides separation device is manual and easy to handle. The main function of this equipment is the radio lanthanides separation from extractive chromatography through packed columns with a commercial resin (Ln SPS) and coated on the top and bottom by fiberglass. The radio lanthanides separation device comprises a main carrousel where the separation columns and elution containers are mounted. It also has a system of open irradiation vials, carrier samples for columns and glassware. This paper presents a detailed description of the radio lanthanides separation device and its management, which allows the radioisotopes production Pm, Tb, Ho, and Lu from the separation of its parents Nd, Dy, Gd, and Yb respectively. (Author)

  8. Separation device of radio lanthanides (DISER)

    International Nuclear Information System (INIS)

    Vera T, A.L.; Monroy G, F.; Vazquez M, J.C.; Jimenez B, F.

    2008-01-01

    At the present time the cancer is one of the main causes of mortality in our country, therefore, its prevention, diagnostic and treatment is of vital importance for those health systems. The treatment of the cancer and other illnesses, starting from monoclonal antibodies, peptides, macro aggregates or marked aminoacids with beta particles emitting radioisotopes, it is an extremely promising field. The radioactive lanthanides: Promethium 149, Terbium 161, Holmium 166 and Lutetium 177 are beta emitting (β), which possess nuclear and chemical properties that have shown their feasibility like radioisotopes of radiotherapeutic use. However, these radioisotopes are not commercially available; to this respect, the Radioactive Materials Research Laboratory (LIMR) of the National Institute of Nuclear Research (ININ), it has developed the methodology of production of these radioisotopes and based on these works, there is designed, built and mounted the Radio lanthanides Separation Device (DISER) able to carry out the radioisotopes production in a routine way. This device is content in a cell that has an auxiliary air service, an extraction system and it is protected with a lead armor-plating of 10 cm. The DISER it is manual and easy of managing. The main function of this equipment is the radio lanthanides separation starting from the extractive chromatography by means of packed columns with a commercial resin (LnSPS) and recovered in the superior and inferior part by fiber glass. The DISER is composed by a main carrousel where the separation columns and the elution recipients are mounted. Also counts with an opening system of irradiation vials, port samples for columns and glass material. The present work presents a detailed description of the DISER, as well as its handling that allows to produce the radioisotopes Promethium-149, Terbium-161, Holmium-166 and Lutetium-177 starting from the separation of its parent elements Neodymium-149, Gadolinium-161, Dysprosium-166 and

  9. Energy storage device with large charge separation

    Science.gov (United States)

    Holme, Timothy P.; Prinz, Friedrich B.; Iancu, Andrei T.

    2018-04-03

    High density energy storage in semiconductor devices is provided. There are two main aspects of the present approach. The first aspect is to provide high density energy storage in semiconductor devices based on formation of a plasma in the semiconductor. The second aspect is to provide high density energy storage based on charge separation in a p-n junction.

  10. Method and device for ion mobility separations

    Science.gov (United States)

    Ibrahim, Yehia M.; Garimella, Sandilya V. B.; Smith, Richard D.

    2017-07-11

    Methods and devices for ion separations or manipulations in gas phase are disclosed. The device includes a single non-planar surface. Arrays of electrodes are coupled to the surface. A combination of RF and DC voltages are applied to the arrays of electrodes to create confining and driving fields that move ions through the device. The DC voltages are static DC voltages or time-dependent DC potentials or waveforms.

  11. Vibration-type particle separation device with piezoceramic vibrator

    Science.gov (United States)

    Ooe, Katsutoshi; Doi, Akihiro

    2008-12-01

    During hemanalysis, it is necessary to separate blood cells from whole blood. Many blood separation methods, for example, centrifugation and filtering, are in practical use. However, the use of these methods involves problems from the perspectives of processing speed and processing volume. We develop new types of blood separation devices that use piezo-ceramic vibrators. The first device uses a capillary. One end of the capillary is fixed to the device frame, and the other is fixed to a piezo-ceramic vibrator. The vibrator transmits bending waves to the capillary. This device can process only a small amount of solution; therefore, it is not suitable for hemanalysis. In order to solve this problem, we developed a second device; this device has a pair of thin glass plates with a small gap as a substitute for the capillary used in the first device. These devices are based on the fact that particles heavier than water move toward transverse velocity antinodes while those lighter than water move toward velocity nodes. In this report, we demonstrate the highspeed separation of silica microbeads and 50-vol% glycerol water by using these devices. The first device can separate the abovementioned solution within 3 min while the second can separate it within 1 min. Both devices are driven by a rectangular wave of 15 to 20 Vpp. Furthermore, it has been confirmed that red blood cells are separated from diluted whole blood using the first device within approximately 1 min. These devices have transparency, so they can compose as the analysis system with the chemical analyzer easily.

  12. Ruthenium separation device from radioactive waste

    International Nuclear Information System (INIS)

    Ayabe, Osao.

    1988-01-01

    Purpose: To efficiently oxidize ruthenium in radioactive wastes and evaporize ruthenium tetraoxide after oxidization thereof, thereby improve the separation and recovery rate. Constitution: The device comprises an oxidization vessel for supplying an oxidizing agent into radioactive wastes to oxidize ruthenium in the wastes into ruthenium tetraoxide, and a distillation vessel for introducing radioactive wastes after oxidization, distillating under heating ruthenium tetraoxide leached into the wastes and evaporizing ruthenium tetraoxide. By dividing the device into the oxidizing vessel and the distillation vessel, the oxidizing treatment and the distilling treatment can individually be operated optimally to improve the separation and recovery rate of ruthenium. (Takahashi, M.)

  13. [Development of an automatic vacuum liquid chromatographic device and its application in the separation of the components from Schisandra chinensis (Turz) Baill].

    Science.gov (United States)

    Zhu, Jingbo; Liu, Baoyue; Shan, Shibo; Ding, Yanl; Kou, Zinong; Xiao, Wei

    2015-08-01

    In order to meet the needs of efficient purification of products from natural resources, this paper developed an automatic vacuum liquid chromatographic device (AUTO-VLC) and applied it to the component separation of petroleum ether extracts of Schisandra chinensis (Turcz) Baill. The device was comprised of a solvent system, a 10-position distribution valve, a 3-position changes valve, dynamic axis compress chromatographic columns with three diameters, and a 10-position fraction valve. The programmable logic controller (PLC) S7- 200 was adopted to realize the automatic control and monitoring of the mobile phase changing, column selection, separation time setting and fraction collection. The separation results showed that six fractions (S1-S6) of different chemical components from 100 g Schisandra chinensis (Turcz) Baill. petroleum ether phase were obtained by the AUTO-VLC with 150 mm diameter dynamic axis compress chromatographic column. A new method used for the VLC separation parameters screened by using multiple development TLC was developed and confirmed. The initial mobile phase of AUTO-VLC was selected by taking Rf of all the target compounds ranging from 0 to 0.45 for fist development on the TLC; gradient elution ratio was selected according to k value (the slope of the linear function of Rf value and development times on the TLC) and the resolution of target compounds; elution times (n) were calculated by the formula n ≈ ΔRf/k. A total of four compounds with the purity more than 85% and 13 other components were separated from S5 under the selected conditions for only 17 h. Therefore, the development of the automatic VLC and its method are significant to the automatic and systematic separation of traditional Chinese medicines.

  14. Particles separation in a cyclone device cone

    Directory of Open Access Journals (Sweden)

    Vasilevsky Michail

    2015-01-01

    Full Text Available The improvement of the methods for calculating the efficiency for particles separation in these devices is the subject of article. Finding data show that the particles are discharged from the central zone to periphery by diffusive transport in the zone of high centripetal accelerations. It is found that the central zone is the ejection effect zone on the paraxial flow and intense discharge particle zone. The concentrations distribution and distribution of fractional efficiencies are presented.

  15. Isotope separator laoratory development

    International Nuclear Information System (INIS)

    Anderl, R.A.

    1977-01-01

    Significant improvements in the capability for collection of mass-separated ions are described. These improvements centered on the fabrication and installation of a more versatile collection-beam viewing system and the design, fabrication, installation and testing of a retardation lens. A summary description of this capability development is presented

  16. Separation membrane development

    Energy Technology Data Exchange (ETDEWEB)

    Lee, M.W. [Savannah River Technology Center, Aiken, SC (United States)

    1998-08-01

    A ceramic membrane has been developed to separate hydrogen from other gases. The method used is a sol-gel process. A thin layer of dense ceramic material is coated on a coarse ceramic filter substrate. The pore size distribution in the thin layer is controlled by a densification of the coating materials by heat treatment. The membrane has been tested by permeation measurement of the hydrogen and other gases. Selectivity of the membrane has been achieved to separate hydrogen from carbon monoxide. The permeation rate of hydrogen through the ceramic membrane was about 20 times larger than Pd-Ag membrane.

  17. Method and device for isotope separation

    International Nuclear Information System (INIS)

    Dawson, J.M.

    1976-01-01

    The method works with a converted Q machine. The plasma containing the isotopes to be separated is crossed by a magnetic field running in the direction of the plasma column. More energy is transfered to the chosen isotope by oscillating magnetic and/or electric fields or by sound waves by using the specific resonance frequency for the selected isotope. The isotopes thus heated to different extents can be separated according to various methods given in the patent claims. (GG) [de

  18. Reaction and separation opportunities with microfluidic devices

    NARCIS (Netherlands)

    Kolfschoten, R.C.

    2011-01-01

    Microfluidic devices make precisely controlled processing of substances possible on a microliter level. The advantage is that, due to the small sizes, the driving forces for mass and heat transfer are high. The surface to volume ratios are also high, which can benefit many surface oriented

  19. Magnet and device for magnetic density separation

    NARCIS (Netherlands)

    Polinder, H.; Rem, P.C.

    2014-01-01

    A planar magnet for magnetic density separation, comprising an array of pole pieces succeeding in longitudinal direction of a mounting plane, each pole piece having a body extending transversely along the mounting plane with a substantially constant cross section that includes a top segment that is

  20. Device for separating ruthenium ion from spent fuel material

    International Nuclear Information System (INIS)

    Izumida, Tatsuo; Sasahira, Akira; Ozawa, Yoshihiro; Kawamura, Fumio.

    1988-01-01

    Purpose: To separate plutonium ions efficiently and selectively from organic solvent containing tributyl phosphate used in the main step of reprocessing process. Constitution: The device comprises, as the main constituent factor, a liquid-liquid contact device for bringing not water soluble organic solvent into contact with a nitric acid solution of spent fuel substances and a liquid-liquid contact-separation device for bringing an organic solvent solution containing spent fuel substances separated with nitric acid into contact again with nitric acid. Then, a device is disposed between two liquid-liquid contact devices for staying ruthenium ions and organic solvent for a sufficient time. In this way, ruthenium ions in the organic solvent containing butyl phosphate are gradually converted into complex compounds combined with tributyl phosphate thereby enabling to separate ruthenium ions efficiently and remarkably reduce the corrosion of equipments. (Horiuchi, T.)

  1. Development of Radiochemical Separation Technology

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Eil Hee; Kim, K. W.; Yang, H. B. (and others)

    2007-06-15

    This project of the second phase was aimed at the development of basic unit technologies for advanced partitioning, and the application tests of pre-developed partitioning technologies for separation of actinides by using a simulated multi-component radioactive waste containing Am, Np, Tc, U and so on. The goals for recovery yield of TRU, and for purity of Tc are high than 99% and about 99%, respectively. The work scopes and contents were as follows. 1). For the development of basic unit technologies for advanced partitioning. 1. Development of technologies for co-removal of TRU and for mutual separation of U and TRU with a reduction-complexation reaction. 2. Development of extraction system for high-acidity co-separation of An(+3) and Ln(+3) and its radiolytic evaluation. 3. Synthesis of extractants for the selective separation of An(+3) and its relevant extraction system development. 4. Development of a hybrid system for the recovery of noble metals and its continuous separation tests. 5. Development of electrolytic system for the decompositions of N-NO3 and N-NH3 compounds to nitrogen gas. 2). For the application test of pre-developed partitioning technologies for the separation of actinide elements in a simulated multi-component solution equivalent to HLW level. 1. Co-separation of Tc, Np and U by a (TBP-TOA)/NDD system. 2. Mutual-separation of Am, Cm and RE elements by a (Zr-DEHPA)/NDD system. All results will be used as the fundamental data for the development of advanced partitioning process in the future.

  2. Medical device development.

    Science.gov (United States)

    Panescu, Dorin

    2009-01-01

    The development of a successful medical product requires not only engineering design efforts, but also clinical, regulatory, marketing and business expertise. This paper reviews items related to the process of designing medical devices. It discusses the steps required to take a medical product idea from concept, through development, verification and validation, regulatory approvals and market release.

  3. Development of Separator for Soybeans

    NARCIS (Netherlands)

    Vries, de H.C.P.; Rijpma, P.J.; Owaa, J.S.E.

    1997-01-01

    A simple and effective separator for soybeans was developed for small-scale farmers in Uganda, to clean the seeds from foreign material, chaff, broken beans etc. as demanded by local and world markets. It will help to avoid losses during post-harvest time and to reduce human drudgery of cleaning the

  4. Development of Separation Materials Containing Palladium for Hydrogen Isotopes Separation

    International Nuclear Information System (INIS)

    Deng Xiaojun; Luo Deli; Qian Xiaojing

    2010-01-01

    Displacement chromatography (DC) is a ascendant technique for hydrogen isotopes separation. The performance of separation materials is a key factor to determine the separation effect of DC. At present,kinds of materials are researched, including palladium materials and non-palladium materials. It is hardly replaceable because of its excellent separation performance, although palladium is expensive. The theory of hydrogen isotopes separation using DC was introduced at a brief manner, while several palladium separation materials were expatiated in detail(Pd/K, Pd-Al 2 O 3 , Pd-Pt alloy). Development direction of separation materials for DC was forecasted elementarily. (authors)

  5. Dynamical phase separation using a microfluidic device: experiments and modeling

    Science.gov (United States)

    Aymard, Benjamin; Vaes, Urbain; Radhakrishnan, Anand; Pradas, Marc; Gavriilidis, Asterios; Kalliadasis, Serafim; Complex Multiscale Systems Team

    2017-11-01

    We study the dynamical phase separation of a binary fluid by a microfluidic device both from the experimental and from the modeling points of view. The experimental device consists of a main channel (600 μm wide) leading into an array of 276 trapezoidal capillaries of 5 μm width arranged on both sides and separating the lateral channels from the main channel. Due to geometrical effects as well as wetting properties of the substrate, and under well chosen pressure boundary conditions, a multiphase flow introduced into the main channel gets separated at the capillaries. Understanding this dynamics via modeling and numerical simulation is a crucial step in designing future efficient micro-separators. We propose a diffuse-interface model, based on the classical Cahn-Hilliard-Navier-Stokes system, with a new nonlinear mobility and new wetting boundary conditions. We also propose a novel numerical method using a finite-element approach, together with an adaptive mesh refinement strategy. The complex geometry is captured using the same computer-aided design files as the ones adopted in the fabrication of the actual device. Numerical simulations reveal a very good qualitative agreement between model and experiments, demonstrating also a clear separation of phases.

  6. A Student-Made Microfluidic Device for Electrophoretic Separation of Food Dyes

    Science.gov (United States)

    Teerasong, Saowapak; McClain, Robert L.

    2011-01-01

    We have developed an undergraduate laboratory activity to introduce students to microfluidics. In the activity, each student constructs their own microfluidic device using simple photolithographic techniques and then uses the device to separate a food dye mixture by electrophoresis. Dyes are used so that students are able to visually observe the…

  7. Device for separating and concentrating rare gases containing krypton gas

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, S; Sugimoto, K

    1975-06-11

    In orer to highly concentrate krypton by means of adsorption and desorption of activated carbon, in a device for continuously separating and concentrating rare gases containing krypton gas by means of adsorbing and desorbing operation of activated carbon, the device includes adsorbers arranged in parallel and more than two stages of adsorbers arranged in series with the first mentioned adsorbers with the amount of activated carbon filled successively reduced, and a cooling mechanism for cooling the adsorbers when adsorbed and a heating mechanism for heating the adsorbers when desorbed.

  8. Device to enrich uranium using the separation nozzle method

    International Nuclear Information System (INIS)

    Wenzel, W.

    1984-01-01

    Separation nozzle units, coolers and the radial-flow compressor are integrated in such manner that the volume of the device is reduced and the efficiency is increased. The radial-flow compressor that is placed in a central and axial position in the cylindrical casing of the tank is concentrically surrounded by the other elements, which are arranged in a way that regular maintenance becomes possible without difficulties. The detailed description is supplemented by drawings. (ori./PW)

  9. Devices for separation of particle emissions from biofuel plants smaller than 10 MW - Today's technology and potential for development; Stoftreningsteknik foer biobraensleanlaeggningar mindre aen 10 MW - tekniklaege och utvecklingspotential

    Energy Technology Data Exchange (ETDEWEB)

    Roennbaeck, Marie; Gustavsson, Lennart; Martinsson, Lars; Tullin, Claes; Johansson, Linda

    2002-09-01

    The objective of this report is to compile a survey of available technologies for separation of particles and to present research and development in the area of particle separation for biofuel plants smaller than 10 MW. Technical and economical opportunities to transfer the technologies used today in larger plants to smaller ones are discussed. As the health effects of aerosols are under investigation, the issue of separation of particle less than 1 {mu}m is especially scrutinised. Current research concerning the particle size distribution at different load is presented. The project has been realised partly as a literature survey, partly through contacts with scientists in the area and manufacturers of devices for flue gas cleaning and particle separation. The target group is owners of plants, manufacturers of devices and authorities with responsibility for air quality and energy planning. Fabric filters is an established technology that can perform low particle emissions (less than a few mg/m{sup 3}) at a low cost also at smaller plants. Also electrostatic precipitators can perform the same low emissions, but the cost for installation at smaller plants has to be reduced. Both these technologies can, properly designed, separate submicron particles. Cyclones can today as its best perform a little less than 100 mg/m{sup 3} at 13 % CO{sub 2}. Cyclones are used together with other technologies to achieve high separation at a low cost. Cyclones are attractive because of their simplicity and low price, but because they use inertia forces as separation mechanism, they can never separate submicron particles. Conventional scrubbers and flue gas condensers are capable of separation of submicron particles but the efficiency is lower compared with fabric filters and electrostatic precipitators. The emission level after a scrubber/flue gas condenser is about 70 - 80 mg/m{sup 3} at 13 % CO{sub 2}. New technologies for separation of particles oriented towards smaller plants and

  10. Separation and extraction device for mixed radioactive waste water

    International Nuclear Information System (INIS)

    Tamachi, Kimio; Takebe, Tsukasa.

    1989-01-01

    The separation device for radioactive sludges comprises cyclone separators each made of conical vessel and arranged in a plurality of stages in series, in which only oils of low density are extracted at the initial stage and heavy sludges are separated from a mixture of water and sludges in the succeeding stage. When sludges are injected at high velocity to the conical vessel in the tangential direction at the edge thereof. The heavy components in the sewage sludges move from the central portion to the outer circumference of the voltex flow and impinge against the inner wall of the vessel. If the vessel is a cylindrical shape or such a shape having a small slope spproximate to that of a cylinder and has short length, the entire portion is swirled and the heavy components are deposited to the inner circumference of the cylinder of the centrifugal force making it difficult for discharge. However, in a vessel of conical shape, since the inner wall of the vessel is inclined, the stream is directed downward by the vertical component thereof and only the heavy components move selectively downward. Thus the size of the device is reduced as a whole and the consumption of filter is reduced. (N.H.)

  11. A new gap separation mechanism for APS insertion devices

    International Nuclear Information System (INIS)

    Trakhtenberg, E. M.; Tcheskidov, V.; Den Hartog, P. K.; Deriy, B.; Erdmann, M.; Makarov, O.; Moog, E. R.

    1999-01-01

    A new gap separation mechanism for use with the standard Advanced Photon Source (APS) 3.3-cm-period undulator magnetic structures has been designed and built and the first system has been installed in the APS storage ring. The system allows a minimum magnetic gap of 10 mm for use with the APS 8-mm insertion device vacuum chambers. The mechanism is a bolted steel frame structure with a simple 4-motor mechanical drive train. The control system uses servomotors with incremental rotary encoders and virtual absolute linear encoders

  12. Cooling process in separation devices of krypton gas

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, S; Sugimoto, K

    1975-06-11

    To prevent entry of impurities into purified gases and to detect leaks of heat exchanger in a separation and recovering device of krypton gas by means of liquefaction and distillation, an intermediate refrigerant having the same or slightly higher boiling point than that of gas to be cooled is used between the gas to be cooled (process gas) and refrigerant (nitrogen), and the pressure of the gas to be cooled is controlled to have a pressure higher than the intermediate refrigerant to cool the gas to be cooled.

  13. A Pressure Controlled Pinched Flow Fractionation Device for Continuous Particle Separation

    DEFF Research Database (Denmark)

    Christiansen, Thomas Lehrmann; Trosborg, Jacqueline; Tanzi, Simone

    2012-01-01

    In this work the problem of separating small particles of di↵erent sizes is solved by developing a simple microfluidic device using pinched flow fractionation (PFF), a technique originally presented by Yamada et al. in 2004 [1]. The present work takes the concept of PFF to the next level by makin...... Polymers GmbH) using a micro machined silicon master. The functionality of the device was confirmed using polymer beads, and by adjusting the pressure accordingly a complete separation of 2 μm and 4.5 μm beads was demonstrated....

  14. An investigation of paper based microfluidic devices for size based separation and extraction applications.

    Science.gov (United States)

    Zhong, Z W; Wu, R G; Wang, Z P; Tan, H L

    2015-09-01

    Conventional microfluidic devices are typically complex and expensive. The devices require the use of pneumatic control systems or highly precise pumps to control the flow in the devices. This work investigates an alternative method using paper based microfluidic devices to replace conventional microfluidic devices. Size based separation and extraction experiments conducted were able to separate free dye from a mixed protein and dye solution. Experimental results showed that pure fluorescein isothiocyanate could be separated from a solution of mixed fluorescein isothiocyanate and fluorescein isothiocyanate labeled bovine serum albumin. The analysis readings obtained from a spectrophotometer clearly show that the extracted tartrazine sample did not contain any amount of Blue-BSA, because its absorbance value was 0.000 measured at a wavelength of 590nm, which correlated to Blue-BSA. These demonstrate that paper based microfluidic devices, which are inexpensive and easy to implement, can potentially replace their conventional counterparts by the use of simple geometry designs and the capillary action. These findings will potentially help in future developments of paper based microfluidic devices. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Space Network Devices Developed

    Science.gov (United States)

    Jones, Robert E.

    2004-01-01

    The NASA Glenn Research Center through a contract with Spectrum Astro, Inc., has been developing space network hardware as an enabling technology using open systems interconnect (OSI) standards for space-based communications applications. The OSI standard is a well-recognized layered reference model that specifies how data should be sent node to node in a communications network. Because of this research and technology development, a space-qualifiable Ethernet-based network interface card (similar to the type found in a networked personal computer) and the associated four-port hub were designed and developed to flight specifications. During this research and development, there also have been many lessons learned for determining approaches for migrating existing spacecraft architectures to an OSI-network-based platform. Industry has recognized the benefits of targeting hardware developed around OSI standards such as Transmission Control Protocol/Internet Protocol (TCP/IP) or similar protocols for use in future generations of space communication systems. Some of these tangible benefits include overall reductions in mission schedule and cost and in system complexity. This development also brings us a step closer to the realization of a principal investigator on a terrestrial Internet site being able to interact with space platform assets in near real time. To develop this hardware, Spectrum Astro first conducted a technology analysis of alternatives study. For this analysis, they looked at the features of three protocol specifications: Ethernet (IEEE 802.3), Firewire (IEEE 1394), and Spacewire (IEEE 1355). A thorough analysis was performed on the basis of criteria such as current protocol performance and suitability for future space applications. Spectrum Astro also projected future influences such as cost, hardware and software availability, throughput performance, and integration procedures for current and transitive space architectures. After a thorough analysis

  16. Optimization of the radio lanthanides separation device; Optimizacion de dispositivo para separacion de radiolantanidos

    Energy Technology Data Exchange (ETDEWEB)

    Vera T, A. L.

    2009-07-01

    At present, cancer is a major cause of mortality in our country, therefore, its prevention, diagnosis and treatment are vital to health systems. The cancer treatment and other diseases, from monoclonal antibodies, peptides, or amino macro aggregates marked with beta particle emitting radionuclides, is a highly promising field. The radioactive lanthanides: Pm, Tb, Ho, and Lu are beta emitters, which possess nuclear and chemical properties, which have shown their feasibility as radioisotopes of radiotherapeutic use. However, these radioisotopes are not available commercially in this connection, the Research Laboratory of Radioactive Materials of the National Institute of Nuclear Research, has developed the methodology of production of these radioisotopes and based on this work is designed, constructed and installed the radio lanthanides separation device for the radioisotopes production routinely. This device is part of the cell, , which has and auxiliary air service, an extraction system and is protected with a 10 cm of lead shielding. The radio lanthanides separation device is manual and easy to handle. The main function of this equipment is the radio lanthanides separation from extractive chromatography through packed columns with a commercial resin (Ln SPS) and coated on the top and bottom by fiberglass. The radio lanthanides separation device comprises a main carrousel where the separation columns and elution containers are mounted. It also has a system of open irradiation vials, carrier samples for columns and glassware. This paper presents a detailed description of the radio lanthanides separation device and its management, which allows the radioisotopes production Pm, Tb, Ho, and Lu from the separation of its parents Nd, Dy, Gd, and Yb respectively. (Author)

  17. A microfluidic device for separation of amniotic fluid mesenchymal stem cells utilizing louver-array structures.

    Science.gov (United States)

    Wu, Huei-Wen; Lin, Xi-Zhang; Hwang, Shiaw-Min; Lee, Gwo-Bin

    2009-12-01

    Human mesenchymal stem cells can differentiate into multiple lineages for cell therapy and, therefore, have attracted considerable research interest recently. This study presents a new microfluidic device for bead and cell separation utilizing a combination of T-junction focusing and tilted louver-like structures. For the first time, a microfluidic device is used for continuous separation of amniotic stem cells from amniotic fluids. An experimental separation efficiency as high as 82.8% for amniotic fluid mesenchymal stem cells is achieved. Furthermore, a two-step separation process is performed to improve the separation efficiency to 97.1%. These results are based on characterization experiments that show that this microfluidic chip is capable of separating beads with diameters of 5, 10, 20, and 40 microm by adjusting the volume-flow-rate ratio between the flows in the main and side channels of the T-junction focusing structure. An optimal volume-flow-rate ratio of 0.5 can lead to high separation efficiencies of 87.8% and 85.7% for 5-microm and 10-microm beads, respectively, in a one-step separation process. The development of this microfluidic chip may be promising for future research into stem cells and for cell therapy.

  18. Reliability analysis for thermal cutting method based non-explosive separation device

    International Nuclear Information System (INIS)

    Choi, Jun Woo; Hwang, Kuk Ha; Kim, Byung Kyu

    2016-01-01

    In order to increase the reliability of a separation device for a small satellite, a new non-explosive separation device is invented. This device is activated using a thermal cutting method with a Ni-Cr wire. A reliability analysis is carried out for the proposed non-explosive separation device by applying the Fault tree analysis (FTA) method. In the FTA results for the separation device, only ten single-point failure modes are found. The reliability modeling and analysis for the device are performed considering failure of the power supply, the Ni-Cr wire burns failure and unwinds, the holder separation failure, the balls separation failure, and the pin release failure. Ultimately, the reliability of the proposed device is calculated as 0.999989 with five Ni-Cr wire coils

  19. Reliability analysis for thermal cutting method based non-explosive separation device

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Jun Woo; Hwang, Kuk Ha; Kim, Byung Kyu [Korea Aerospace University, Goyang (Korea, Republic of)

    2016-12-15

    In order to increase the reliability of a separation device for a small satellite, a new non-explosive separation device is invented. This device is activated using a thermal cutting method with a Ni-Cr wire. A reliability analysis is carried out for the proposed non-explosive separation device by applying the Fault tree analysis (FTA) method. In the FTA results for the separation device, only ten single-point failure modes are found. The reliability modeling and analysis for the device are performed considering failure of the power supply, the Ni-Cr wire burns failure and unwinds, the holder separation failure, the balls separation failure, and the pin release failure. Ultimately, the reliability of the proposed device is calculated as 0.999989 with five Ni-Cr wire coils.

  20. Paper-based device for separation and cultivation of single microalga.

    Science.gov (United States)

    Chen, Chih-Chung; Liu, Yi-Ju; Yao, Da-Jeng

    2015-12-01

    Single-cell separation is among the most useful techniques in biochemical research, diagnosis and various industrial applications. Microalgae species have great economic importance as industrial raw materials. Microalgae species collected from environment are typically a mixed and heterogeneous population of species that must be isolated and purified for examination and further application. Conventional methods, such as serial dilution and a streaking-plate method, are intensive of labor and inefficient. We developed a paper-based device for separation and cultivation of single microalga. The fabrication was simply conducted with a common laser printer and required only a few minutes without lithographic instruments and clean-room. The driving force of the paper device was simple capillarity without a complicated pump connection that is part of most devices for microfluidics. The open-structure design of the paper device makes it operable with a common laboratory micropipette for sample transfer and manipulation with a naked eye or adaptable to a robotic system with functionality of high-throughput retrieval and analysis. The efficiency of isolating a single cell from mixed microalgae species is seven times as great as with a conventional method involving serial dilution. The paper device can serve also as an incubator for microalgae growth on simply rinsing the paper with a growth medium. Many applications such as highly expressed cell selection and various single-cell analysis would be applicable. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. The development of zirconia membrane oxygen separation technology

    International Nuclear Information System (INIS)

    Chiacchi, F.T.; Badwal, S.P.S.; Velizko, V.

    2000-01-01

    The oxygen separation technology based on ceramic membranes constructed from stabilised zirconia is currently under development for applications ranging from oxygen generation or air enrichment for medical use to control of oxygen concentration or oxygen removal from gas streams and enclosures for semiconductor, food packaging and process control instrumentation industries. The technology is based on a rugged tubular design with extensive thermal cycling capability. Several single and three tube devices have been operated for periods up to 5000h. An eight tube module, as a building block for larger scale oxygen production or removal devices, has been constructed and is being evaluated. In this paper, the construction of the device, oxygen generating capacity, life time tests and performance of the ceramic membrane device under development at CSIRO will be discussed. Copyright (2000) The Australian Ceramic Society

  2. Designing and modeling a centrifugal microfluidic device to separate target blood cells

    International Nuclear Information System (INIS)

    Shamloo, Amir; Selahi, AmirAli; Madadelahi, Masoud

    2016-01-01

    The objective of this study is to design a novel and efficient portable lab-on-a-CD (LOCD) microfluidic device for separation of specific cells (target cells) using magnetic beads. In this study the results are shown for neutrophils as target cells. However, other kinds of target cells can be separated in a similar approach. The designed microfluidics can be utilized as a point of care system for neutrophil detection. This microfluidic system employs centrifugal and magnetic forces for separation. After model validation by the experimental data in the literature (that may be used as a design tool for developing centrifugo-magnetophoretic devices), two models are presented for separation of target cells using magnetic beads. The first model consists of one container in the inlet section and two containers in the outlets. Initially, the inlet container is filled with diluted blood sample which is a mixture of red blood cells (RBCs) plus neutrophils which are attached to Magnetic beads. It is shown that by using centrifugal and magnetic forces, this model can separate all neutrophils with recovery factor of ∼100%. In the second model, due to excess of magnetic beads in usual experimental analysis (to ensure that all target cells are attached to them) the geometry is improved by adding a third outlet for these free magnetic beads. It is shown that at angular velocity of 45 rad s −1 , recovery factor of 100% is achievable for RBCs, free magnetic beads and neutrophils as target cells. (paper)

  3. Designing and modeling a centrifugal microfluidic device to separate target blood cells

    Science.gov (United States)

    Shamloo, Amir; Selahi, AmirAli; Madadelahi, Masoud

    2016-03-01

    The objective of this study is to design a novel and efficient portable lab-on-a-CD (LOCD) microfluidic device for separation of specific cells (target cells) using magnetic beads. In this study the results are shown for neutrophils as target cells. However, other kinds of target cells can be separated in a similar approach. The designed microfluidics can be utilized as a point of care system for neutrophil detection. This microfluidic system employs centrifugal and magnetic forces for separation. After model validation by the experimental data in the literature (that may be used as a design tool for developing centrifugo-magnetophoretic devices), two models are presented for separation of target cells using magnetic beads. The first model consists of one container in the inlet section and two containers in the outlets. Initially, the inlet container is filled with diluted blood sample which is a mixture of red blood cells (RBCs) plus neutrophils which are attached to Magnetic beads. It is shown that by using centrifugal and magnetic forces, this model can separate all neutrophils with recovery factor of ~100%. In the second model, due to excess of magnetic beads in usual experimental analysis (to ensure that all target cells are attached to them) the geometry is improved by adding a third outlet for these free magnetic beads. It is shown that at angular velocity of 45 rad s-1, recovery factor of 100% is achievable for RBCs, free magnetic beads and neutrophils as target cells.

  4. Development and evaluation of separation elements

    International Nuclear Information System (INIS)

    Guimaraes, R.R.R.; Rocha, Z.

    1990-01-01

    For industrial testing of the uranium enrichment technology by the jet nozzle process, it is being erected in Resende the 'First Cascade' (FC) and it was built the Separation Element Plant (FES). For the development, optimization and quality control of the separation elements produced by FES, it was set up in CDTN a laboratorial infrastructure. As part of it, it was designed, built and assembled the Separation Slit Testing Equipment (ITRS), with several components developed and constructed in CDTN. The tests are being carried out in ITRS with the objective of adjusting the machine tools of FES used in the line production of the separation elements. From the satisfactory results obtained with these tests, FES will start the production of separation tubes to be installed in FC. The objective of this paper is to describe the operation and evaluation tests in ITRS, as well as to present their contribution to the development and quality control of the separation elements produced in FES. (author) [pt

  5. Method and device for the separation of particles

    NARCIS (Netherlands)

    Rem, P.C.; Van Kooy, L.A.

    2004-01-01

    The invention relates to a method of in a liquid separating a mixture of particles that within chosen limits have different physical property values, wherein the particles to be separated are supplied via a feeder to a screen upon which a layer of facilitating particles is disposed, the size of the

  6. Steam/water separation device for drying a wet vapour

    International Nuclear Information System (INIS)

    Sundheimer, P.

    1986-01-01

    The aim of the present invention is to dry a wet vapour which flows up to the device. The device has at least a group of steam dryer elements in a zone in which there is a vertical apertured panel; this vertical apertured panel is a metal grille with baffles the inlet steam flow to make it horizontal or slightly inclined to the bottom. The invention applies more particularly, to PWR steam generators [fr

  7. Procedure and device for separating isotopes of high mass

    International Nuclear Information System (INIS)

    Eerkens, J.W.

    1977-01-01

    The invention refers to isotope separation and to selectively photon-induced energy transfer from an isotope molecule containing the isotope to be separated as well as to a chemical reaction with a reactive agent in order to produce a chemical compound containing atoms of the desired isotope. For example, in the most preferable form of the invention, gaseous UF 6 is contained in a mixture of U 235 F 6 and U 238 F 6 molecules in a reaction chamber. A chemically reactive substance, which for U 235 separation may be gaseous HCl according to the invention, is also introduced into the reaction chamber. (HK) [de

  8. On recent developments in marginal separation theory.

    Science.gov (United States)

    Braun, S; Scheichl, S

    2014-07-28

    Thin aerofoils are prone to localized flow separation at their leading edge if subjected to moderate angles of attack α. Although 'laminar separation bubbles' at first do not significantly alter the aerofoil performance, they tend to 'burst' if α is increased further or if perturbations acting upon the flow reach a certain intensity. This then either leads to global flow separation (stall) or triggers the laminar-turbulent transition process within the boundary layer flow. This paper addresses the asymptotic analysis of the early stages of the latter phenomenon in the limit as the characteristic Reynolds number [Formula: see text], commonly referred to as marginal separation theory. A new approach based on the adjoint operator method is presented that enables the fundamental similarity laws of marginal separation theory to be derived and the analysis to be extended to higher order. Special emphasis is placed on the breakdown of the flow description, i.e. the formation of finite-time singularities (a manifestation of the bursting process), and on its resolution being based on asymptotic arguments. The passage to the subsequent triple-deck stage is described in detail, which is a prerequisite for carrying out a future numerical treatment of this stage in a proper way. Moreover, a composite asymptotic model is developed in order for the inherent ill-posedness of the Cauchy problems associated with the current flow description to be resolved.

  9. Tube leak detection device and acoustic sensor support device for moisture separating heater

    International Nuclear Information System (INIS)

    Miyabe, Keisuke; Kobayashi, Takefumi.

    1995-01-01

    The device of the present invention comprises an acoustic sensor which detects leak sounds when leak occurs in a heating tube of a moisture separating heater incorporated into a plant, a threshold value memory and switching mechanism containing each of threshold values on every power of a plant, and a leak judging mechanism for judging presence or absence of leaks by comparing a selected threshold value and signals given from the acoustic sensor. Background noises changing currently during operation of a steam turbine plant are compared with a threshold value greater than the background noises in the leak judging mechanism, and they are judged as 'no leak' so as not to recognize them as 'presence of tube leak'. Output values from the acoustic sensor are obtained on every frequency component, and standard frequency spectra are selected by turbine load corresponding signals using a standard spectra memory and switching mechanism. They are sent to a leak judging mechanism to analyze the acoustic signals using a frequency analyzer and compare them with the frequency spectral thereby judging leaks. (N.H.)

  10. Gas separation device based on electrical swing adsorption

    Science.gov (United States)

    Judkins, Roddie R.; Burchell, Timothy D.

    1999-10-26

    A method and apparatus for separating one constituent, especially carbon dioxide, from a fluid mixture, such as natural gas. The fluid mixture flows through an adsorbent member having an affinity for molecules of the one constituent, the molecules being adsorbed on the adsorbent member. A voltage is applied to the adsorbent member, the voltage imparting a current flow which causes the molecules of the one constituent to be desorbed from the adsorbent member.

  11. Separation of magnetic beads in a hybrid continuous flow microfluidic device

    Energy Technology Data Exchange (ETDEWEB)

    Samanta, Abhishek [Haldia Institute of Technology, Production Engineering Department, Haldia (India); Ganguly, Ranjan; Datta, Amitava [Jadavpur University, Power Engineering Department (India); Modak, Nipu, E-mail: nmechju@gmail.com [Jadavpur University, Mechanical Engineering Department (India)

    2017-04-01

    Magnetic separation of biological entities in microfluidic environment is a key task for a large number of bio-analytical protocols. In magnetophoretic separation, biochemically functionalized magnetic beads are allowed to bind selectively to target analytes, which are then separated from the background stream using a suitably imposed magnetic field. Here we present a numerical study, characterizing the performance of a magnetophoretic hybrid microfluidic device having two inlets and three outlets for immunomagnetic isolation of three different species from a continuous flow. The hybrid device works on the principle of split-flow thin (SPLITT) fractionation and field flow fractionation (FFF) mechanisms. Transport of the magnetic particles in the microchannel has been predicted following an Eulerian-Lagrangian model and using an in-house numerical code. Influence of the salient geometrical parameters on the performance of the separator is studied by characterizing the particle trajectories and their capture and separation indices. Finally, optimum channel geometry is identified that yields the maximum capture efficiency and separation index. - Highlights: • Immunomagnetic separation in a hybrid microchannel design is investigated numerically. • Influence of salient geometric parameters on the device performance is analysed. • Optimum device dimension for best separation parameters are identified. • Optimized design of hybrid separator performs better than FFF or SPLITT devices.

  12. The promise of nanotechnology for separation devices - from a top-down approach to nature-inspired separation devices

    NARCIS (Netherlands)

    Eijkel, Jan C.T.; van den Berg, Albert

    An overview is given of the possible applications of nanotechnology to optimise existing separation methods and to enable new methods. Attention is paid to nanotechnological contributions in the fields of HPLC, CEC, sieves, Brownian ratchets and preconcentration units. A brief description is also

  13. The testing of a steam-water separating device used for vertical steam generators

    International Nuclear Information System (INIS)

    Ding Xunshen; Cui Baoyuan; Xue Yunkui; Liu Shixun

    1989-01-01

    The air-water screening tests of a steam-water separating device used for vertical steam generators at low pressure are introduced. The article puts emphasis on the qualification test of the steam-water separating device at hot conditions in a high temperature and pressure water test rig. The performance of the comprehensive test of the steam-water separating device indicates that the humidity of the steam at the drier exit is much less than the specified amount of 0.25%

  14. A scalable, micropore, platelet rich plasma separation device.

    Science.gov (United States)

    Dickson, Mary Nora; Amar, Levy; Hill, Michael; Schwartz, Joseph; Leonard, Edward F

    2012-12-01

    We have designed a novel, low energy platelet-rich-plasma (PRP) separator capable of producing 50 mL of PRP in 30 min, intended for military and emergency applications. Blood flows over a 3 mm length of sieve at high rates of shear. A plasma-platelet filtrate passes through the sieve's pores while erythrocytes remain. The filtrate is flowed over a second 3 mm length of smaller-pored sieve that withdraws plasma. Bulk blood volume is maintained by returning platelet-free plasma to the erythrocyte pool, enabling a nearly complete multi-pass platelet extraction. The total percentage of platelets extracted is:θ(T)=1-exp (-V(f)(T)Φ(P)/V) where V is the original plasma volume, V ( f )(T) is the total filtered volume, and ϕ ( P ) is platelet passage ratio (filtrate concentration/bulk average concentration) taken to be constant. Maximum θ(T) occurs at maximum V ( f )(T)× ϕ ( P ) Test microsieves, 3 mm long × 3 mm wide, were used. ϕ ( P ) values measured at various filtrate flow rates (20-100 uL/min) and utilizing various filter pore sizes (1.2-3.5 μm), was as high as 150 %. Maximum V ( f )(T)× ϕ ( P ) was achieved utilizing the 3.5 um filters at the highest flow rate, 100 uL/min. Erythrocyte leakages were always below 2,000/uL, far below the allowable limit stipulated by the American Association of Blood Banking. These data imply that a 13.7 cm(2) filter area is sufficient to achieve the target separation of 50 mL of platelet concentrate in 30 min. The filtration cartridge would consist of multiple microporous strips of 3 mm width arranged in parallel so that each element would see the conditions used in the prototype experiments presented here. Other microfiltration schemes suggest no method of scaling to practical levels.

  15. Separation of density and viscosity influence on liquid-loaded surface acoustic wave devices

    Science.gov (United States)

    Herrmann, F.; Hahn, D.; Büttgenbach, S.

    1999-05-01

    Love-mode sensors are reported for separate measurement of liquid density and viscosity. They combine the general merits of Love-mode devices, e.g., ease of sensitivity adjustment and robustness, with a highly effective procedure of separate determination of liquid density and viscosity. A model is proposed to describe the frequency response of the devices to liquid loading. Moreover, design rules are given for further optimization and sensitivity enhancement.

  16. Separation device of radio lanthanides (DISER); Dispositivo de separacion de radiolantanidos (DISER)

    Energy Technology Data Exchange (ETDEWEB)

    Vera T, A.L. [FES-Zaragoza, UNAM, 09000 Mexico D.F. (Mexico); Monroy G, F.; Vazquez M, J.C.; Jimenez B, F. [ININ, 52750 La Marquesa, Estado de Mexico (Mexico)]. e-mail: veratrevino@hotmail.com

    2008-07-01

    At the present time the cancer is one of the main causes of mortality in our country, therefore, its prevention, diagnostic and treatment is of vital importance for those health systems. The treatment of the cancer and other illnesses, starting from monoclonal antibodies, peptides, macro aggregates or marked aminoacids with beta particles emitting radioisotopes, it is an extremely promising field. The radioactive lanthanides: Promethium 149, Terbium 161, Holmium 166 and Lutetium 177 are beta emitting ({beta}), which possess nuclear and chemical properties that have shown their feasibility like radioisotopes of radiotherapeutic use. However, these radioisotopes are not commercially available; to this respect, the Radioactive Materials Research Laboratory (LIMR) of the National Institute of Nuclear Research (ININ), it has developed the methodology of production of these radioisotopes and based on these works, there is designed, built and mounted the Radio lanthanides Separation Device (DISER) able to carry out the radioisotopes production in a routine way. This device is content in a cell that has an auxiliary air service, an extraction system and it is protected with a lead armor-plating of 10 cm. The DISER it is manual and easy of managing. The main function of this equipment is the radio lanthanides separation starting from the extractive chromatography by means of packed columns with a commercial resin (LnSPS) and recovered in the superior and inferior part by fiber glass. The DISER is composed by a main carrousel where the separation columns and the elution recipients are mounted. Also counts with an opening system of irradiation vials, port samples for columns and glass material. The present work presents a detailed description of the DISER, as well as its handling that allows to produce the radioisotopes Promethium-149, Terbium-161, Holmium-166 and Lutetium-177 starting from the separation of its parent elements Neodymium-149, Gadolinium-161, Dysprosium-166

  17. Effect of swirling device on flow behavior in a supersonic separator for natural gas dehydration

    DEFF Research Database (Denmark)

    Wen, Chuang; Li, Anqi; Walther, Jens Honore

    2016-01-01

    is designed for an annular supersonic separator. The supersonic swirling separation flow of natural gas is calculated using the Reynolds Stress model. The results show that the viscous heating and strong swirling flow cause the adverse pressure in the annular channel, which may negatively affect......The supersonic separator is a revolutionary device to remove the condensable components from gas mixtures. One of the key issues for this novel technology is the complex supersonic swirling flow that is not well understood. A swirling device composed of an ellipsoid and several helical blades...

  18. Integrated Lateral Flow Device for Flow Control with Blood Separation and Biosensing

    Directory of Open Access Journals (Sweden)

    Veronica Betancur

    2017-12-01

    Full Text Available Lateral flow devices are versatile and serve a wide variety of purposes, including medical, agricultural, environmental, and military applications. Yet, the most promising opportunities of these devices for diagnosis might reside in point-of-care (POC applications. Disposable paper-based lateral flow strips have been of particular interest, because they utilize low-cost materials and do not require expensive fabrication instruments. However, there are constraints on tuning flow rates and immunoassays functionalization in papers, as well as technical challenges in sensors’ integration and concentration units for low-abundant molecular detection. In the present work, we demonstrated an integrated lateral flow device that applied the capillary forces with functionalized polymer-based microfluidics as a strategy to realize a portable, simplified, and self-powered lateral flow device (LFD. The polydimethylsiloxane (PDMS surface was rendered hydrophilic via functionalization with different concentrations of Pluronic F127. Controlled flow is a key variable for immunoassay-based applications for providing enough time for protein binding to antibodies. The flow rate of the integrated LFD was regulated by the combination of multiple factors, including Pluronic F127 functionalized surface properties and surface treatments of microchannels, resistance of the integrated flow resistor, the dimensions of the microstructures and the spacing between them in the capillary pump, the contact angles, and viscosity of the fluids. Various plasma flow rates were regulated and achieved in the whole device. The LFD combined the ability to separate high quality plasma from human whole blood by using a highly asymmetric plasma separation membrane, and created controlled and steady fluid flow using capillary forces produced by the interfacial tensions. Biomarker immunoglobulin G (IgG detection from plasma was demonstrated with a graphene nanoelectronic sensor integrated

  19. Using an Elastic Band Device After a Severe Obstetric Pubic Symphyseal Separation: Clinical and Imaging Evaluation.

    Science.gov (United States)

    Lasbleiz, Jeremy; Sevestre, François-Xavier; Moquet, Pierre-Yves

    2017-09-01

    Severe separation of the pubic symphysis is a rare delivery complication. Facing this pathology, we decided to study a new elastic band device. To evaluate the elastic band device, clinical (pain-rated) and imaging (magnetic resonance imaging and radiography) evaluations with and without the device were performed. The elastic band device is a European Conformity-certified medical device, which is made of neoprene straps, that reduces the mobility of the pelvis and the use of the internal rotator muscles. Once the elastic band device was in place, on postpartum day 1, radiography showed a decrease of the pubic width from 41 to 12 mm. Furthermore, pain decreased from 10 of 10 to 2 of 10 in 2 days, allowing the patient to ambulate and avoid surgery. After 1 month, the pubic width (6 mm) and anatomy were recovered but minor pain was still present with hip rotatory movements. The elastic band device was worn 24 hours a day from postpartum days 1-90 and 12 hours a day from postpartum days 90 to 150; afterward, the patient returned to normal life without the elastic band device. Use of an elastic band device was associated with a reduction of the pubic width and pain associated after obstetric pubic symphysis separation.

  20. Recent developments in optical detection methods for microchip separations

    NARCIS (Netherlands)

    Götz, S.; Karst, U.

    2007-01-01

    This paper summarizes the features and performances of optical detection systems currently applied in order to monitor separations on microchip devices. Fluorescence detection, which delivers very high sensitivity and selectivity, is still the most widely applied method of detection. Instruments

  1. Computational Flow Dynamic Simulation of Micro Flow Field Characteristics Drainage Device Used in the Process of Oil-Water Separation

    Directory of Open Access Journals (Sweden)

    Guangya Jin

    2017-01-01

    Full Text Available Aqueous crude oil often contains large amounts of produced water and heavy sediment, which seriously threats the safety of crude oil storage and transportation. Therefore, the proper design of crude oil tank drainage device is prerequisite for efficient purification of aqueous crude oil. In this work, the composition and physicochemical properties of crude oil samples were tested under the actual conditions encountered. Based on these data, an appropriate crude oil tank drainage device was developed using the principle of floating ball and multiphase flow. In addition, the flow field characteristics in the device were simulated and the contours and streamtraces of velocity magnitude at different nine moments were obtained. Meanwhile, the improvement of flow field characteristics after the addition of grids in crude oil tank drainage device was validated. These findings provide insights into the development of effective selection methods and serve as important references for oil-water separation process.

  2. Thixotropic gel-like composition and sterile blood-collecting and separating device

    International Nuclear Information System (INIS)

    Semersky, F.E.

    1980-01-01

    A thixotropic gel-like composition comprising liquid polybutadiene and an inorganic inert filler dispersed therein is adapted for use as a sealing barrier between separated phases of differing densities of a fluid in which said composition has at rest a density intermediate said differing densities, said gel-like composition being substantially resistant to sterilizing radiation. There is also disclosed a pre-packaged blood collecting and separating device which contains a mixture of liquid polybutadiene and an inorganic, inert filler, such as silica, as a thixotropic gel adapted at rest to form a sealing barrier between separated blood phases. The device and gel are subjected to sterilizing radiation to form a substantially sterile device, substantially free of backflow contamination without degradation of the physical properties of the gel. (author)

  3. A reactor/separator device for use in automated solid phase immunoassay

    International Nuclear Information System (INIS)

    Farina, P.R.; Ordonez, K.P.; Siewers, I.J.

    1979-01-01

    A reactor/separator device is described for use in automated solid phase immunoassay, including radioimmunoassays. The device is a column fitted at the bottom portion with a water impermeable disc which can hold, for example, immunoabsorbents, immobilized antisera or ion exchange resins. When the contents of the column supported by the disc are brought into contact with an aqueous phase containing reagents or reactants, a chemical reaction is initiated. After the reaction, centrifugally applied pressure forces the aqueous phase through the filter disc making it water permeable and separating a desired component for subsequent analysis. The reactor/separator device of the present invention permits kinetic solid phase assays (non-equilibrium conditions) to be carried out which would be difficult to perform by other conventional methods. (author)

  4. Output channel design for collecting closely-spaced particle streams from spiral inertial separation devices

    Directory of Open Access Journals (Sweden)

    Caffiyar Mohamed Yousuff

    2017-08-01

    Full Text Available Recent advances in inertial microfluidics designs have enabled high throughput, label-free separation of cells for a variety of bioanalytical applications. Various device configurations have been proposed for binary separation with a focus on enhancing the separation distance between particle streams to improve the efficiency of separate particle collection. These configurations have not demonstrated scaling beyond 3 particle streams either because the channel width is a constraint at the collection outlets or particle streams would be too closely spaced to be collected separately. We propose a method to design collection outlets for inertial focusing and separation devices which can collect closely-spaced particle streams and easily scale to an arbitrary number of collection channels without constraining the outlet channel width, which is the usual cause of clogging or cell damage. According to our approach, collection outlets are a series of side-branching channels perpendicular to the main channel of egress. The width and length of the outlets can be chosen subject to constraints from the position of the particle streams and fluidic resistance ratio computed from fluid dynamics simulations. We show the efficacy of this approach by demonstrating a successful collection of upto 3 particle streams of 7μm, 10μm and 15μm fluorescent beads which have been focused and separated by a spiral inertial device with a separation distance of only 10μm -15μm. With a throughput of 1.8mL/min, we achieved collection efficiency exceeding 90% for each particle at the respective collection outlet. The flexibility to use wide collection channels also enabled us to fabricate the microfluidic device with an epoxy mold that was created using xurography, a low cost, and imprecise fabrication technique.

  5. Design and simulation of a microfluidic device for acoustic cell separation.

    Science.gov (United States)

    Shamloo, Amir; Boodaghi, Miad

    2018-03-01

    Experimental acoustic cell separation methods have been widely used to perform separation for different types of blood cells. However, numerical simulation of acoustic cell separation has not gained enough attention and needs further investigation since by using numerical methods, it is possible to optimize different parameters involved in the design of an acoustic device and calculate particle trajectories in a simple and low cost manner before spending time and effort for fabricating these devices. In this study, we present a comprehensive finite element-based simulation of acoustic separation of platelets, red blood cells and white blood cells, using standing surface acoustic waves (SSAWs). A microfluidic channel with three inlets, including the middle inlet for sheath flow and two symmetrical tilted angle inlets for the cells were used to drive the cells through the channel. Two interdigital transducers were also considered in this device and by implementing an alternating voltage to the transducers, an acoustic field was created which can exert the acoustic radiation force to the cells. Since this force is dependent to the size of the cells, the cells are pushed towards the midline of the channel with different path lines. Particle trajectories for different cells were obtained and compared with a theoretical equation. Two types of separations were observed as a result of varying the amplitude of the acoustic field. In the first mode of separation, white blood cells were sorted out through the middle outlet and in the second mode of separation, platelets were sorted out through the side outlets. Depending on the clinical needs and by using the studied microfluidic device, each of these modes can be applied to separate the desired cells. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Recent developments in optical detection methods for microchip separations.

    Science.gov (United States)

    Götz, Sebastian; Karst, Uwe

    2007-01-01

    This paper summarizes the features and performances of optical detection systems currently applied in order to monitor separations on microchip devices. Fluorescence detection, which delivers very high sensitivity and selectivity, is still the most widely applied method of detection. Instruments utilizing laser-induced fluorescence (LIF) and lamp-based fluorescence along with recent applications of light-emitting diodes (LED) as excitation sources are also covered in this paper. Since chemiluminescence detection can be achieved using extremely simple devices which no longer require light sources and optical components for focusing and collimation, interesting approaches based on this technique are presented, too. Although UV/vis absorbance is a detection method that is commonly used in standard desktop electrophoresis and liquid chromatography instruments, it has not yet reached the same level of popularity for microchip applications. Current applications of UV/vis absorbance detection to microchip separations and innovative approaches that increase sensitivity are described. This article, which contains 85 references, focuses on developments and applications published within the last three years, points out exciting new approaches, and provides future perspectives on this field.

  7. Trends in Supersonic Separator design development

    Directory of Open Access Journals (Sweden)

    Altam Rami Ali

    2017-01-01

    Full Text Available Supersonic separator is a new technology with applications in hydrocarbon dew pointing and gas dehydration which can be used to condensate and separate water and heavy hydrocarbons from natural gas. Many researchers have studied the design, performance and efficiency, economic viability, and industrial applications of these separators. The purpose of this paper is to succinctly review recent progress in the design and application of supersonic separators and their limitations. This review has found that while several aspects of this study are well studied, considerable gaps within the published literature still exists in the areas such as turndown flexibility which is a critical requirement to cater for variation of mass flow and since almost all the available designs have a fixed geometry and therefore cannot be considered suitable for variable mass flow rate, which is a common situation in actual site. Hence, the focus needs to be more on designing a flexible geometry that can maintain a high separation efficiency regardless of inlet conditions and mass flow variations. This review is focusing only on the design and application of the supersonic separators without going through the experimental facilities, industrial platform, pilot plants as well as theoretical, analytical, and numerical modelling.

  8. Development on the automatic separator of separation of residual powders from SF hulls

    International Nuclear Information System (INIS)

    Jung, Jae Hoo; Kim, Young Hwang; Kim, Ki Ho; Park, Byung Buk; Lee, Hyo Jik; Kim, Sung Hyun; Park, Hee Sung; Lee, Jong Kwang; Kim, Ho Dong

    2009-12-01

    At the previous process of auto hull separator, vol-oxidizer convert UO 2 pellets to U 3 O 8 powder, and in the next step, hulls and powders is collected into each part of two vessels. In order to enhance the recover rate, fine powders on the surface of hulls should be removed from hulls. Auto hulls separator for fine powders is a device which can separate fine powders from hulls. In order to design and manufacture this device, we analyzed fine powders which are remained on the surface of hulls for separation properties, and selected separation and operation methods. Also, the main mechanism is devised by using the design considerations. These main mechanism consists of rotation drum, parts feeder, hull conveyer, powders separator, air shower, and vessels. Design considerations for auto hulls separator as follows ; capacity : 100 kg HM/batch, rod-cut length : 50 mm, recovery rate for fine powders : 95 % and operation condition : over 12 hrs/batch. We considered connection methods of the vessel and high vacuum module which can join with the outlet of auto hulls separator. Also, by using the above results, we have manufactured auto hulls separator for fine powders, and conducted blank tests for operation condition. Here, hulls of 50 mm length for test are used with 20 kg HM/batch. We have conducted separation tests of 2 batches to collect fine powders with hulls of 10 kg HM/batch. Our goal of recovery rate was 95%, but in the test result, the recovery rate of fine powders on the surface of hulls was over 96 %

  9. Numerical simulation of a cyclone used as an inlet device of a gravitational separator

    Energy Technology Data Exchange (ETDEWEB)

    Moraes, Carlos Alberto Capela [Centro de Pesquisas da PETROBRAS (CENPES), Rio de Janeiro, RJ (Brazil). Gerencia de Tecnologia de Processamento Primario], E-mail: capela@petrobras.com.br; Oliveira Junior, Joao Americo Aguirre; Almeida, Lucilla Coelho de [Engineering Simulation and Scientific Software (ESSS), Florianopolis, SC (Brazil)], E-mails: joao.aguirre@esss.com.br, lucilla@esss.com.br

    2011-04-15

    This study presents the numerical simulation of the flow inside a gravitational separator to evaluate the influence of each internal device in the separation efficiency. In this first stage, the cyclone - located at the vessel entrance, known as the primary separation - internal flow is investigated. The flow inside cyclones presents rather complex and challenging characteristics, such as: streamlines with high curvature, intense force fields, interaction between primary and secondary flows and anisotropic turbulence. A three-dimensional fluid dynamics study is presented of a gas-liquid two-phase flow in a cyclone. The two-phase flow was modeled using an Eulerian, isothermal approach. The main conclusion of these simulations is the phase separation inside the proposed initial design does not occur by centrifugal effect, as an internal rotating flow is not established, due to an ineffective inlet design. Based on the lack of this expected centrifugal field for a cyclone, it can be concluded that the device does not behave as such. As a result, the device efficiency is limited and possibly small droplets will be carried by the gas stream. Therefore, changes to the cyclone inlet geometry were proposed to better achieve the cyclone effect to increase the separation efficiency. (author)

  10. Environmental Development Plan for advanced isotope separation

    International Nuclear Information System (INIS)

    1979-05-01

    This EDP identifies the planning and management requirements and schedules needed to evaluate and assess the environmental, health, and safety aspects of the Advanced Isotope Separation (AIS) program. Current AIS processes include the molecular and atomic vapor laser processes and the plasma process. This document covers the technology program, environmental concerns and requirements, and environmental strategy

  11. Innovative developments in uranium separation and concentration technology abroad

    International Nuclear Information System (INIS)

    Liang Jinlong; Zhou Mingsheng; Fang Wei; Sun Yuxiang

    2014-01-01

    Significance of deeply study the innovative developments in Uranium separation and concentration technology abroad was discussed. Development history and innovativeness of eight species of key equipments for separation and concentration were summarized for the first time. Principle and application of seven Uranium separation and concentration technology were analyzed systematically. It is expounded in the paper that high parameter, intelligent and low carbon were three development trends of Uranium separation and concentration technology. (authors)

  12. Sequencing of real-world samples using a microfabricated hybrid device having unconstrained straight separation channels.

    Science.gov (United States)

    Liu, Shaorong; Elkin, Christopher; Kapur, Hitesh

    2003-11-01

    We describe a microfabricated hybrid device that consists of a microfabricated chip containing multiple twin-T injectors attached to an array of capillaries that serve as the separation channels. A new fabrication process was employed to create two differently sized round channels in a chip. Twin-T injectors were formed by the smaller round channels that match the bore of the separation capillaries and separation capillaries were incorporated to the injectors through the larger round channels that match the outer diameter of the capillaries. This allows for a minimum dead volume and provides a robust chip/capillary interface. This hybrid design takes full advantage, such as sample stacking and purification and uniform signal intensity profile, of the unique chip injection scheme for DNA sequencing while employing long straight capillaries for the separations. In essence, the separation channel length is optimized for both speed and resolution since it is unconstrained by chip size. To demonstrate the reliability and practicality of this hybrid device, we sequenced over 1000 real-world samples from Human Chromosome 5 and Ciona intestinalis, prepared at Joint Genome Institute. We achieved average Phred20 read of 675 bases in about 70 min with a success rate of 91%. For the similar type of samples on MegaBACE 1000, the average Phred20 read is about 550-600 bases in 120 min separation time with a success rate of about 80-90%.

  13. Sustainable development of gree solvent separation process

    OpenAIRE

    Lisickov, Kiril; Fidancevska, Emilija; Grujic, Radoslav; Srebrenkoska, Vineta; Kuvendziev, Stefan

    2011-01-01

    Solvents defi ne a major part of the environmental performance of processes in the chemical industry and impact on cost, safety and health issues. The idea of green solvents expresses the goal to minimize the environmental impact resulting from the use of solvents in chemical production. In spite of conventional separation methods, precise process green technologies are based on the application of modern processes and process equipment as well as control and management...

  14. Separation of red blood cells in deep deterministic lateral displacement devices

    Science.gov (United States)

    Kabacaoglu, Gokberk; Biros, George

    2017-11-01

    Microfluidic cell separation techniques are of great interest since they help rapid medical diagnoses and tests. Deterministic lateral displacement (DLD) is one of them. A DLD device consists of arrays of pillars. Main flow and alignment of the pillars define two different directions. Size-based separation of rigid spherical particles is possible as they follow one of these directions depending on their sizes. However, the separation of non-spherical deformable particles such as red blood cells (RBCs) is more complicated than that due to their intricate dynamics. We study the separation of RBCs in DLD using an in-house integral equation solver. We systematically investigate the effects of the interior fluid viscosity and the membrane elasticity of an RBC on its behavior. These mechanical properties of a cell determine its deformability, which can be altered by several diseases. We particularly consider deep devices in which an RBC can show rich dynamics such as tank-treading and tumbling. It turns out that strong hydrodynamic lift force moves the tank-treading cells along the pillars and downward force leads the tumbling ones to move with the flow. Thereby, deformability-based separation of RBCs is possible.

  15. Development of immobilized ligands for actinide separations

    International Nuclear Information System (INIS)

    Paine, R.T.

    1994-01-01

    Primary goals during this grant period were to (1) synthesize new bifunctional chelating ligands, (2) characterize the structural features of the Ln and An coordination complexes formed by these ligands, (3) use structural data to iteratively design new classes of multifunctional ligands, and (4) explore additional routes for attachment of key ligands to solid supports that could be useful for chromatographic separations. Some highlights of recently published work as well as a summary of submitted, unpublished and/or still in progress research are outlined

  16. Analysis of the role of elution buffers on the separation capabilities of dielectrophoretic devices

    Directory of Open Access Journals (Sweden)

    Rossana Di Martino

    2016-03-01

    Full Text Available Field flow fractionation dielectrophoretic (FFF-DEP devices are currently used, among the others, for the separation of tumor cells from healthy blood cells. To this end specific suspension/elution buffers (EBs, with reduced conductivity (with respect to that of the cell cytoplasm are generally used. In this paper we investigate the long-term alterations of the cells and elution buffers. We find that the EB conductivity is critically modified within few minutes after cells suspension. In turn, this modification results in a change the ideal separation frequency of the FFF-DEP device. On the other hand we prove that DEP manipulation is preserved for more than three hours for cells suspended in the considered EBs. Keywords: Dielectrophoresis, Elution buffer, Circulating tumor cells, Cell motility

  17. Development of a novel heavy element chemistry apparatus using the RIKEN gas-field recoil separator as a pre-separator

    International Nuclear Information System (INIS)

    Haba, H.; Morita, K.; Enomoto, S.; Morimoto, K.; Kaji, D.; Nagame, Yuichiro

    2004-01-01

    A new system was developed, that supplied the super-heavy element separated physically as the former steps to the chemical analysis devices such as a gas or liquid chromatographs. The gas jet transportation device was newly set up on the edge of existing accelerator research facilities in the Institute of Physical and Chemical Research linac building (GARIS). To conduct the chemical separation experiment of a super-heavy element of 112 in future a radioactive isotope of mercury of light homology elements was manufactured with a gas jet uniting type online multi-tracer manufacturing device. The adsorption chromatograph experiment to the gold was performed using this system. (H. Katsuta)

  18. Development of superconducting equipment for fusion device

    International Nuclear Information System (INIS)

    Konno, Masayuki; Ueda, Toshio; Hiue, Hisaaki; Ohgushi, Kouzou

    1993-01-01

    At Fuji Electric Co., Ltd., the development of superconductivity was started from 1960, and superconducting equipment for fusion device has been developed for ten years. The superconducting equipment, which is developed for fusion by Fuji Electric Co., Ltd., are able to be grouped in three categories which are current lead, superconducting coil and superconducting bus-line. The current lead is an electrical feeder between a superconducting coil and an electrical power supply. The rated current of developed current lead is 30kA at continuous use and 100kA at short time use respectively. The advanced disk type coil is developed for the toroidal field coil and some coils are developed for critical current measurement. Superconductor is applied to the superconducting bus-line between the superconducting coils and the current leads, and the bus-line is being developed for the Large Helical Device. This report describes an abstract of these equipment. (author)

  19. Microfluidic device having an immobilized pH gradient and PAGE gels for protein separation and analysis

    Science.gov (United States)

    Sommer, Gregory J.; Hatch, Anson V.; Singh, Anup K.; Wang, Ying-Chih

    2012-12-11

    Disclosed is a novel microfluidic device enabling on-chip implementation of a two-dimensional separation methodology. Previously disclosed microscale immobilized pH gradients (IPG) are combined with perpendicular polyacrylamide gel electrophoresis (PAGE) microchannels to achieve orthogonal separations of biological samples. Device modifications enable inclusion of sodium dodecyl sulfate (SDS) in the second dimension. The device can be fabricated to use either continuous IPG gels, or the microscale isoelectric fractionation membranes we have also previously disclosed, for the first dimension. The invention represents the first all-gel two-dimensional separation microdevice, with significantly higher resolution power over existing devices.

  20. A Chip-Capillary Hybrid Device for Automated Transfer of Sample Pre-Separated by Capillary Isoelectric Focusing to Parallel Capillary Gel Electrophoresis for Two-Dimensional Protein Separation

    Science.gov (United States)

    Lu, Joann J.; Wang, Shili; Li, Guanbin; Wang, Wei; Pu, Qiaosheng; Liu, Shaorong

    2012-01-01

    In this report, we introduce a chip-capillary hybrid device to integrate capillary isoelectric focusing (CIEF) with parallel capillary sodium dodecyl sulfate – polyacrylamide gel electrophoresis (SDS-PAGE) or capillary gel electrophoresis (CGE) toward automating two-dimensional (2D) protein separations. The hybrid device consists of three chips that are butted together. The middle chip can be moved between two positions to re-route the fluidic paths, which enables the performance of CIEF and injection of proteins partially resolved by CIEF to CGE capillaries for parallel CGE separations in a continuous and automated fashion. Capillaries are attached to the other two chips to facilitate CIEF and CGE separations and to extend the effective lengths of CGE columns. Specifically, we illustrate the working principle of the hybrid device, develop protocols for producing and preparing the hybrid device, and demonstrate the feasibility of using this hybrid device for automated injection of CIEF-separated sample to parallel CGE for 2D protein separations. Potentials and problems associated with the hybrid device are also discussed. PMID:22830584

  1. Developing and validating a sham cupping device.

    Science.gov (United States)

    Lee, Myeong Soo; Kim, Jong-In; Kong, Jae Cheol; Lee, Dong-Hyo; Shin, Byung-Cheul

    2010-12-01

    The aims of this study were to develop a sham cupping device and to validate its use as a placebo control for healthy volunteers. A sham cupping device was developed by establishing a small hole to reduce the negative pressure after suction such that inner pressure could not be maintained in the cup. We enrolled 34 healthy participants to evaluate the validity of the sham cupping device as a placebo control. The participants were informed that they would receive either real or sham cupping and were asked which treatment they thought they had received. Other sensations and adverse events related to cupping therapy were investigated. 17 patients received real cupping therapy and 17 received sham cupping. The two groups felt similar sensations. There was a tendency for subjects to feel that real cupping created a stronger sensation than sham cupping (48.9±21.4 vs 33.3±20.3 on a 100mm visual analogue scale). There were only mild to moderate adverse events observed in both groups. We developed a new sham cupping device that seems to provide a credible control for real cupping therapy by producing little or no negative pressure. This conclusion was supported by a pilot study, but more rigorous research is warranted regarding the use of this device.

  2. Ion age transport: developing devices beyond electronics

    Science.gov (United States)

    Demming, Anna

    2014-03-01

    There is more to current devices than conventional electronics. Increasingly research into the controlled movement of ions and molecules is enabling a range of new technologies. For example, as Weihua Guan, Sylvia Xin Li and Mark Reed at Yale University explain, 'It offers a unique opportunity to integrate wet ionics with dry electronics seamlessly'. In this issue they provide an overview of voltage-gated ion and molecule transport in engineered nanochannels. They cover the theory governing these systems and fabrication techniques, as well as applications, including biological and chemical analysis, and energy conversion [1]. Studying the movement of particles in nanochannels is not new. The transport of materials in rock pores led Klinkenberg to describe an analogy between diffusion and electrical conductivity in porous rocks back in 1951 [2]. And already in 1940, Harold Abramson and Manuel Gorin noted that 'When an electric current is applied across the living human skin, the skin may be considered to act like a system of pores through which transfer of substances like ragweed pollen extract may be achieved both by electrophoretic and by diffusion phenomena' [3]. Transport in living systems through pore structures on a much smaller scale has attracted a great deal of research in recent years as well. The selective transport of ions and small organic molecules across the cell membrane facilitates a number of functions including communication between cells, nerve conduction and signal transmission. Understanding these processes may benefit a wide range of potential applications such as selective separation, biochemical sensing, and controlled release and drug delivery processes. In Germany researchers have successfully demonstrated controlled ionic transport through nanopores functionalized with amine-terminated polymer brushes [4]. The polymer nanobrushes swell and shrink in response to changes in temperature, thus opening and closing the nanopore passage to ionic

  3. Study of mechanism of hydrogen diffusion in separation devices. Progress report for 1980-1983

    International Nuclear Information System (INIS)

    Lee, M.H.

    1983-01-01

    For the purpose of studying the mechanisms of hydrogen diffusion in separation devices e.g. transition-metal membranes, we have developed a microscopic dynamic model appropriate for describing the nonequilibrium statistical mechanics of hydrogen-in-a-metal. Using this model we have carried out a detailed analysis to obtain the autocorrelation function of density fluctuations in the model. Our model is built on the physical idea that, at low temperatures, spin clusters are the basic units or aggregates of transport. Our work can explain the reversed isotope effect in diffusion. We have also obtained an expression for the relative diffusivity, verifiable by experiments with tritium in metals. Our notion of spin clusters is novel. There is some evidence of their existence. The interstitial spin clusters are comparable to atomic and nuclear spin clusters, the only other natural spin clusters. Our demonstration of a long-time tail in the autocorrelation function is also novel. Diffusion can be anomalous if long time tails exist, a current topic in nonlinear behavior of fluids and solids. Our progress has been made possible by our development in the mathematical method of solving the generalized Langevin equation. This method is applicable to any time-dependent quantum many-body model. The underlying basis of this method is our discovery of a new orthogonalization process in Hilbert space, first since Gram and Schmidt over 100 years ago. Our process is simpler if Hilbert space is realized as is for all physical problems. To demonstrate the power and utility of our method we considered a well established model of metals, thereby discovering the existence of a low-frequency electronic mobility. This kind of intrinsic conductivity should exist in ensembles of all light particles, hence also relevant to hydrogen and its isotopes in metals

  4. Development and evaluation of vision rehabilitation devices.

    Science.gov (United States)

    Luo, Gang; Peli, Eli

    2011-01-01

    We have developed a range of vision rehabilitation devices and techniques for people with impaired vision due to either central vision loss or severely restricted peripheral visual field. We have conducted evaluation studies with patients to test the utilities of these techniques in an effort to document their advantages as well as their limitations. Here we describe our work on a visual field expander based on a head mounted display (HMD) for tunnel vision, a vision enhancement device for central vision loss, and a frequency domain JPEG/MPEG based image enhancement technique. All the evaluation studies included visual search paradigms that are suitable for conducting indoor controllable experiments.

  5. Latest development on the membrane formation for gas separation

    Directory of Open Access Journals (Sweden)

    Ahmad Fausi Ismail

    2002-11-01

    Full Text Available The first scientific observation related to gas separation was encountered by J.K Mitchell in 1831. However, the most remarkable and influential contribution to membrane gas separation technology was the systematic study by Thomas Graham in 1860. However only in 1979, membrane based gas separation technology was available and recognized as one of the most recent and advanced unit operations for gas separation processes. Membrane is fabricated by various methods and the parameters involved to a certain extent are very complicated. The phase inversion technique that is normally employed to produce membranes are dry/wet, wet, dry and thermal induced phase separation. Other techniques used to produce membrane are also reviewed. This paper reports the latest development in membrane formation for gas separation. The route to produce defect-free and ultrathin-skinned asymmetric membrane is also presented that represents the cutting edge technology in membrane gas separation process

  6. Sperm quality assessment via separation and sedimentation in a microfluidic device.

    Science.gov (United States)

    Chen, Chang-Yu; Chiang, Tsun-Chao; Lin, Cheng-Ming; Lin, Shu-Sheng; Jong, De-Shien; Tsai, Vincent F-S; Hsieh, Ju-Ton; Wo, Andrew M

    2013-09-07

    A major reason for infertility is due to male factors, including the quality of spermatozoa, which is a primary factor and often difficult to assess, particularly the total sperm concentration and its motile percentage. This work presents a simple microfluidic device to assess sperm quality by quantifying both total and motile sperm counts. The key design feature of the microfluidic device is two channels separated by a permeative phase-guide structure, where one channel is filled with raw semen and the other with pure buffer. The semen sample was allowed to reach equilibrium in both chambers, whereas non-motile sperms remained in the original channel, and roughly half of the motile sperms would swim across the phase-guide barrier into the buffer channel. Sperms in each channel agglomerated into pellets after centrifugation, with the corresponding area representing total and motile sperm concentrations. Total sperm concentration up to 10(8) sperms per ml and motile percentage in the range of 10-70% were tested, encompassing the cutoff value of 40% stated by World Health Organization standards. Results from patient samples show compact and robust pellets after centrifugation. Comparison of total sperm concentration between the microfluidic device and the Makler chamber reveal they agree within 5% and show strong correlation, with a coefficient of determination of R(2) = 0.97. Motile sperm count between the microfluidic device and the Makler chamber agrees within 5%, with a coefficient of determination of R(2) = 0.84. Comparison of results from the Makler Chamber, sperm quality analyzer, and the microfluidic device revealed that results from the microfluidic device agree well with the Makler chamber. The sperm microfluidic chip analyzes both total and motile sperm concentrations in one spin, is accurate and easy to use, and should enable sperm quality analysis with ease.

  7. Microporous polyethylene separators — today and tomorrow. Separator development trends for modern automotive batteries

    Science.gov (United States)

    Böhnstedt, Werner

    During the past decade, the design of modern automotive batteries has undergone a fundamental change. The introduction of microporous polyethylene pocket separators has resulted in an approximately 8% better volume utilization. Besides increasing the energy density, the polyethylene envelope has enalbed an improvement in cold-cranking performance and has raised the production efficiency. A first failure-mode analysis of pocket-separated automotive batteries in Europe with respect to leaf separation is presented. For comparable service life, a shift in failure mode has been found. Although corrosion of the positive electrode still dominates, a significant increase in positive active-material shedding is noted. This is certainly a consequence of the general trend towards lower antimony contents. Shorting through the separator is only found in cases of severe battery mistreatment. This positive, intermediary result is supplemented by an outlook on emerging development trends. Future automotive batteries will experience elevated operating temperatures, higher cycling loads, and maintenance freedom. Battery tests at temperatures up to 75 °C with various alloy combinations show that the hybrid design is best suited to meet the expected requirements. Microporous polyethylene pocket separation is not expected to be a limiting factor; the trend to lower antimony alloy content and increased cycling load will demonstrate the advantage of this separation even more clearly than in the past. Optimization of the already achieved, balanced separator characteristics profile with the reference parameters of electrical performance, water loss, durability and machinability will stimulate further development work.

  8. Development of Mobile Device for Oil Analysis

    Directory of Open Access Journals (Sweden)

    I. Macuzic

    2010-09-01

    Full Text Available This paper presents the results of project focused on development and practical application of mobile instrument for on-site analysis of industrial oils. For years, the implementation of the oil analysis was limited to a specialized laboratories, but the emergence of proactive maintenance concept, cause intensive development of devices and sensors that strive in direction of miniaturization, automation, performance enhancement and creation of multi-functional diagnostic systems. Proactive maintenance strategy involves continuous monitoring and control of the basic failure causes, among which oil contamination stands out as the most common, serious and generally widely accepted cause of failures in the industry. Using the sensor elements to determine the concentration of wear particles and water in oil, the prototype of mobile device for contamination control of mineral oil is developed. It meets the general and specific set of technical and technological requirements, has a favourable price and upgrade option.

  9. Proximity sensing of electrostatic induction electret nanoparticles device using separation electrode

    Directory of Open Access Journals (Sweden)

    Jianxiong Zhu

    2017-04-01

    Full Text Available We reported a two dimensional self-powered proximity sensor based on nanoparticles polytetrafluoroethylene (PTFE electrostatic induction electret using separation electrode. The structural pattern was carefully designed for identifying the specific position on the horizontal plane. When the separation electrode is motioned above the sensor, the induced charges on electrodes will change based on the coupling effect of the electret film. Experiment results showed that the proximity sensor works well with the velocity 0.05 m/s. We also found that the prototype have a good stability even with a huge uncontrolled perturbation on the Y direction. Our work could be a significant step forward in self-powered proximity sensing technology, with a wide range of potential applications in touchpad, robotics, and safety-monitoring device.

  10. Development of High Throughput Salt Separation System with Integrated Liquid Salt Separation - Salt Distillation Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Sangwoon; Park, K. M.; Kim, J. G.; Jeong, J. H.; Lee, S. J.; Park, S. B.; Kim, S. S.

    2013-01-15

    The capacity of a salt distiller should be sufficiently large to reach the throughput of uranium electro-refining process. In this study, an assembly composing a liquid separation sieve and a distillation crucible was developed for the sequential operation of a liquid salt separation and a vacuum distillation in the same tower. The feasibility of the sequential salt separation was examined by the rotation test of the sieve-crucible assembly and sequential operation of a liquid salt separation and a vacuum distillation. The adhered salt in the uranium deposits was removed successfully. The salt content in the deposits was below 0.1 wt% after the sequential operation of the liquid salt separation - salt distillation. From the results of this study, it could be concluded that efficient salt separation can be realized by the sequential operation of liquid salt separation and vacuum distillation in one distillation tower since the operation procedures are simplified and no extra operation of cooling and reheating is necessary.

  11. Membrane separation systems---A research and development needs assessment

    Energy Technology Data Exchange (ETDEWEB)

    Baker, R.W. (Membrane Technology and Research, Inc., Menlo Park, CA (USA)); Cussler, E.L. (Minnesota Univ., Minneapolis, MN (USA). Dept. of Chemical Engineering and Materials Science); Eykamp, W. (California Univ., Berkeley, CA (USA)); Koros, W.J. (Texas Univ., Austin, TX (USA)); Riley, R.L. (Separation Systems Technology, San Diego, CA (USA)); Strathmann, H. (Fraunhofer-Institut fuer Grenzflaech

    1990-03-01

    Membrane based separation technology, a relative newcomer on the separations scene, has demonstrated the potential of saving enormous amounts of energy in the processing industries if substituted for conventional separation systems. Over 1 quad annually, out of 2.6, can possibly be saved in liquid-to-gas separations, alone, if membrane separation systems gain wider acceptance, according to a recent DOE/OIP (DOE/NBM-80027730 (1986)) study. In recent years great strides have been made in the field and offer even greater energy savings in the future when substituted for other conventional separation techniques such as distillation, evaporation, filtration, sedimentation, and absorption. An assessment was conducted by a group of six internationally known membrane separations experts who examined the worldwide status of research in the seven major membrane areas. This encompassed four mature technology areas: reverse osmosis, micorfiltration, ultrafiltration, and electrodialysis; two developing areas: gas separation and and pervaporation; and one emerging technology: facilitated transport. Particular attention was paid to identifying the innovative processes currently emerging, and even further improvements which could gain wider acceptance for the more mature membrane technology. The topics that were pointed out as having the greatest research emphasis are pervaporation for organic-organic separations; gas separation; micorfiltration; an oxidant-resistant reverse osmosis membrane; and a fouling-resistant ultrafiltration membrane. 35 refs., 6 figs., 22 tabs.

  12. Development of superconducting power devices in Europe

    International Nuclear Information System (INIS)

    Tixador, Pascal

    2010-01-01

    Europe celebrated last year (2008) the 100-year anniversary of the first liquefaction of helium by H. Kammerling Onnes in Leiden. It led to the discovery of superconductivity in 1911. Europe is still active in the development of superconducting (SC) devices. The discovery of high critical temperature materials in 1986, again in Europe, has opened a lot of opportunities for SC devices by broking the 4 K cryogenic bottleneck. Electric networks experience deep changes due to the emergence of dispersed generation (renewable among other) and to the advances in ICT (Information Communication Technologies). The networks of the future will be 'smart grids'. Superconductivity will offer 'smart' devices for these grids like FCL (Fault Current Limiter) or VLI (Very Low Inductance) cable and would certainly play an important part. Superconductivity also will participate to the required sustainable development by lowering the losses and enhancing the mass specific powers. Different SC projects in Europe will be presented (Cable, FCL, SMES, Flywheel and Electrical Machine) but the description is not exhaustive. Nexans has commercialized the first two FCLs without public funds in the European grid (UK and Germany). The Amsterdam HTS cable is an exciting challenge in term of losses for long SC cables. European companies (Nexans, Air Liquide, Siemens, Converteam, ...) are also very active for projects outside Europe (LIPA, DOE FCL, ...).

  13. An innovative device for powders classification based on combined aerodynamic and electrostatic separation of particles

    Science.gov (United States)

    Piriou, Bruno; Mayer-Laigle, Claire; Maalel, Firas; Plissot, Jorys; Rouau, Xavier

    2017-06-01

    An innovative separator have been developed which aims at sorting out powders fractions according to aerodynamic and electrostatic properties of particles. The prototype is composed of a projection unit, a separation module and a classification/collection zone. The projection part is ensured by a pressurized gun. The separation module is conceived to disperse particles according to front and transverse directions. At the output of the gun, electrodes can be disposed to deviate the trajectory of charged particles. The classification part is made of a series of collecting bins. Starch, fine ash powders, and mixtures of these two materials were used to test the working of the separator. The efficiency of the separation was assessed by yields and particle sizes distribution of the collected fractions in the different bins. An aerodynamic classification was achieved along the main axis, with the finest particles crossing larger distances. With a blend of starch and ash, particles from both materials were unevenly distributed in the classifyier, opening the way to a possible separation based simply on aerodynamic properties. When an electric deviation was applied in addition to the projection of powders, the distribution of particles in the collecting part was modified.

  14. An innovative device for powders classification based on combined aerodynamic and electrostatic separation of particles

    Directory of Open Access Journals (Sweden)

    Piriou Bruno

    2017-01-01

    Full Text Available An innovative separator have been developed which aims at sorting out powders fractions according to aerodynamic and electrostatic properties of particles. The prototype is composed of a projection unit, a separation module and a classification/collection zone. The projection part is ensured by a pressurized gun. The separation module is conceived to disperse particles according to front and transverse directions. At the output of the gun, electrodes can be disposed to deviate the trajectory of charged particles. The classification part is made of a series of collecting bins. Starch, fine ash powders, and mixtures of these two materials were used to test the working of the separator. The efficiency of the separation was assessed by yields and particle sizes distribution of the collected fractions in the different bins. An aerodynamic classification was achieved along the main axis, with the finest particles crossing larger distances. With a blend of starch and ash, particles from both materials were unevenly distributed in the classifyier, opening the way to a possible separation based simply on aerodynamic properties. When an electric deviation was applied in addition to the projection of powders, the distribution of particles in the collecting part was modified.

  15. Recent developments in the theory of separately holomorphic mappings

    International Nuclear Information System (INIS)

    Viet-Anh Nguyen; vietanh 1974@yahoo.fr

    2007-07-01

    We describe a part of the recent developments in the theory of separately holomorphic mappings between complex analytic spaces. Our description focuses on works using the technique of holomorphic discs. (author)

  16. Separations chemistry for f elements: Recent developments and historical perspective

    International Nuclear Information System (INIS)

    Nash, K.L.; Choppin, G.R.

    1995-01-01

    With the end of the cold war, the principal mission in actinide separations has changed from production of plutonium to cleanup of the immense volume of moderately radioactive mixed wastes which resulted from fifty years of processing activities. In order to approach the cleanup task from a proper perspective, it is necessary to understand the nature of the problem and how the wastes were generated. In this report, the history of actinide separations, both the basic science and production aspects, is examined. Many of the separations techniques in use today were developed in the 40's and 50's for the identification and production of actinide elements. To respond to the modern world of actinide separations new techniques are being developed for separations ranging from analytical methods to detect ultra-trace concentrations (for bioassay and environmental monitoring) to large scale waste treatment procedures. Some of these new methods are ''improvements'' or adaptations of the historical techniques. Total actinide recovery, lanthanide/actinide separations, and selective partitioning of actinides from inert constituents are of primary concern. This report, offers a historical perspective, review the current status of f element separation processes, and suggest areas for continued research in both actinide separations and waste cleanup/environment remediation

  17. Fluidic separation in microstructured devices – concepts and their Integration into process flow networks

    NARCIS (Netherlands)

    Vural - Gürsel, I.; Kockmann, N.; Hessel, V.

    2017-01-01

    FDA and pharmaceutical industry turn the vision of integrated end-to-end manufacturing currently into reality. Accordingly, besides the efforts to develop reactions in continuous flow, it is also essential to consider separation of reaction mixtures and purification of the desired product - and how

  18. Development of formulation device for periodontal disease.

    Science.gov (United States)

    Sato, Yasuhiko; Oba, Takuma; Watanabe, Norio; Danjo, Kazumi

    2012-01-01

    In addition to providing standard surgical treatment that removes the plaque and infected tissues, medications that can regenerate periodontal tissue are also required in the treatment of periodontal disease. As a form of regenerative medication, various growth factors are expected to be used while treating periodontal disease. A protein-like growth factor is often developed as a lyophilized product with dissolution liquid, considering its instability in the solution state. We have clarified that the formulation for periodontal disease needs to be viscous. When the lyophilized product was dissolved using a sticky solution, various problems were encountered, difficulty in dissolving and air bubbles, for example, and some efforts were needed to prepare the formulation. In this research, to identify the problem of preparing a viscous formulation, a lyophilized product (placebo) and sticky liquid were prepared by using vial and ampoule as the conventional containers. Based on these problems, a prototype administration device was developed, and its functionality was confirmed. As a result, it was suggested that the device with a useful mixing system that could shorten the preparation time was developed.

  19. Simultaneous pre-concentration and separation on simple paper-based analytical device for protein analysis.

    Science.gov (United States)

    Niu, Ji-Cheng; Zhou, Ting; Niu, Li-Li; Xie, Zhen-Sheng; Fang, Fang; Yang, Fu-Quan; Wu, Zhi-Yong

    2018-02-01

    In this work, fast isoelectric focusing (IEF) was successfully implemented on an open paper fluidic channel for simultaneous concentration and separation of proteins from complex matrix. With this simple device, IEF can be finished in 10 min with a resolution of 0.03 pH units and concentration factor of 10, as estimated by color model proteins by smartphone-based colorimetric detection. Fast detection of albumin from human serum and glycated hemoglobin (HBA1c) from blood cell was demonstrated. In addition, off-line identification of the model proteins from the IEF fractions with matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) was also shown. This PAD IEF is potentially useful either for point of care test (POCT) or biomarker analysis as a cost-effective sample pretreatment method.

  20. Development of Smartphone based Optical Device

    Science.gov (United States)

    Jung, Youngkee

    Due to the economy of scale, smartphones are becoming more affordable while their computing powers are increasing dramatically every year. Here we propose a ubiquitous and portable instrument for analyte quantitation by utilizing the characteristics of typical smartphone imaging system and specific design of transducers for different applications. Three testbeds included in this work are: quantitative colorimetric analysis, ultra-low radiant flux detection, and portable spectrometer. As a proof-of-principle for each device, 3-D printed cradle and theoretical simulation with MATLAB have been implemented. First example utilizes the native CMOS camera with their respective RGB channel data and perform an analyte quantitation for typical lateral flow devices (LFD). Histogram analysis method has been employed to detect the analyte concentration and calibration results show good correlation between perceived color change and analyte concentration. The second example shows the possibility of using a conventional CMOS camera for pico Watt level photon flux detection. Since most of consumer grade CMOS cameras cannot detect this level of light intensity and their dark current are relatively higher, a new algorithm called NREA (Noise Reduction by Ensemble Averaging) algorithm was developed to effectively reduce the noise level and increase the SNR (signal to noise ratio). This technique is effective for bioanalytical assays that has lower flux intensity such as fluorescence and luminescence. As a proof-of-principle, we tested the device with Pseudomonas fluorescens M3A and achieved a limit of detection of high 10? CFU/ml. In addition to basic schematic of detection model, another experiment with a silicon photomultiplier (SiPM) has been studied for more sensitive light detectability. Based on both the laser experiment and tw bioluminescent experiments, named Pseudomonas fluorescens M3A and NanoLuc, we found that the miniSM based device has a superior ability than the

  1. Development and testing of a separator frame in a Norway lobster Nephrops norvegicus fishery

    DEFF Research Database (Denmark)

    Madsen, Niels; Holst, René

    2017-01-01

    Norway lobster Nephrops norvegicus fisheries are often characterized by high bycatch and discard rates. However, fisheries species exhibit differences in vertical behaviour that can be used to develop selective devices. We developed a separator frame that can be inserted into the forward part...... the separator frame and ending up in the bottom cod-end, the top cod-end, or penetrating the window. The majority of Norway lobster and flatfish entered the bottom cod-end, and most gadoids entered the top cod-end. A relatively high proportion of gadoids and flatfish that entered the top cod-end penetrated...

  2. Flexible Bistable Smectic-A Liquid Crystal Device Using Photolithography and Photoinduced Phase Separation

    Directory of Open Access Journals (Sweden)

    Yang Lu

    2012-01-01

    Full Text Available A flexible bistable smectic-A liquid crystal (SmA LC device using pixel-isolated mode was demonstrated, in which SmA LC molecules were isolated in pixels by vertical polymer wall and horizontal polymer layer. The above microstructure was achieved by using ultraviolet (UV photolithography and photoinduced phase separation. The polymer wall was fabricated by photolithography, and then the SmA LC was encapsulated in pixels between polymer wall through UV-induced phase separation, in which the polymer wall acts as supporting structure from mechanical pressure and maintains the cell gap from bending, and the polymer layer acts as adhesive for tight attachment of two substrates. The results demonstrated that all the intrinsic bistable properties of the SmA LC are preserved, and good electrooptical characteristics such as high contrast ratio and excellent stability of the bistable states were characterized. This kind of SmA bistable flexible display has high potential to be used as electronic paper, smart switchable reflective windows, and so forth.

  3. Separations chemistry for actinide elements: Recent developments and historical perspective

    International Nuclear Information System (INIS)

    Nash, K.L.; Choppin, G.R.

    1997-01-01

    With the end of the cold war, the principal mission in actinide separations has changed from production of plutonium to cleanup of the immense volume of moderately radioactive mixed wastes which resulted from fifty years of processing activities. In order to approach the cleanup task from a proper perspective, it is necessary to understand how the wastes were generated. Most of the key separations techniques central to actinide production were developed in the 40's and 50's for the identification and production of actinide elements. Total actinide recovery, lanthanide/actinide separations, and selective partitioning of actinides from inert constituents are currently of primary concern. To respond to the modern world of actinide separations, new techniques are being developed for separations ranging from analytical methods to detect ultra-trace concentrations (for bioassay and environmental monitoring) to large-scale waste treatment procedures. In this report, the history of actinide separations, both the basic science and production aspects, is examined and evaluated in terms of contemporary priorities

  4. Magnetic filtration of phase separating ferrofluids: From basic concepts to microfluidic device

    Science.gov (United States)

    Kuzhir, P.; Magnet, C.; Ezzaier, H.; Zubarev, A.; Bossis, G.

    2017-06-01

    In this work, we briefly review magnetic separation of ferrofluids composed of large magnetic particles (60 nm of the average size) possessing an induced dipole moment. Such ferrofluids exhibit field-induced phase separation at relatively low particle concentrations (∼0.8 vol%) and magnetic fields (∼10 kA/m). Particle aggregates appearing during the phase separation are extracted from the suspending fluid by magnetic field gradients much easier than individual nanoparticles in the absence of phase separation. Nanoparticle capture by a single magnetized microbead and by multi-collector systems (packed bed of spheres and micro-pillar array) has been studied both experimentally and theoretically. Under flow and magnetic fields, the particle capture efficiency Λ decreases with an increasing Mason number for all considered geometries. This decrease may become stronger for aggregated magnetic particles (Λ ∝Ma-1.7) than for individual ones (Λ ∝Ma-1) if the shear fields are strong enough to provoke aggregate rupture. These results can be useful for development of new magneto-microfluidic immunoassays based on magnetic nanoparticles offering a much better sensitivity as compared to presently used magnetic microbeads.

  5. Separations technology development to support accelerator-driven transmutation concepts

    International Nuclear Information System (INIS)

    Venneri, F.; Arthur, E.; Bowman, C.

    1996-01-01

    This is the final report of a one-year Laboratory-Directed Research and Development (LDRD) Project at the Los Alamos National Laboratory (LANL). This project investigated separations technology development needed for accelerator-driven transmutation technology (ADTT) concepts, particularly those associated with plutonium disposition (accelerator-based conversion, ABC) and high-level radioactive waste transmutation (accelerator transmutation of waste, ATW). Specific focus areas included separations needed for preparation of feeds to ABC and ATW systems, for example from spent reactor fuel sources, those required within an ABC/ATW system for material recycle and recovery of key long-lived radionuclides for further transmutation, and those required for reuse and cleanup of molten fluoride salts. The project also featured beginning experimental development in areas associated with a small molten-salt test loop and exploratory centrifugal separations systems

  6. Development of an integrated crucible for the salt separation

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, S. W.; Park, K. M.; Jeong, J. H.; Lee, H. S.; Kim, J. G. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2012-05-15

    Pyroprocessing has been developed for the recovery of actinide elements from spent fuel due to its advantages. Electrorefining is a key step in pyroprocessing. The electrorefining process is generally composed of two recovery steps. The deposit of uranium onto a solid cathode and the recovery of the remaining uranium and TRU elements simultaneously by a liquid cadmium cathode. The solid cathode processing is necessary to separate the salt from the cathode since the uranium deposit in a solid cathode contains electrolyte salt. A physical separation process, such as distillation separation, is more attractive than a chemical or dissolution process because physical processes generate much less secondary process. Distillation process was employed for the cathode process sing due to the advantages of minimal generation of secondary waste, compact unit process, simple and low cost equipment. The basis for vacuum distillation separation is the difference in vapor pressures between salt and uranium. A solid cathode deposit is heated in a heating region and salt vaporizes, while non volatile uranium remains behind. It is very important to increase the throughput of the salt separation system due to the high uranium content of spent nuclear fuel and high salt fraction of uranium dendrites. The evaporation rate of the LiCl-KCl eutectic salt in vacuum distiller is not so high to come up with the generation capacity of uranium dendrites in electro-refiner. Therefore, wide evaporation area or high distillation temperature is necessary for the successful salt separation. In this study, the integrated salt separation system was developed to increase the throughput of the salt removal process by the separation of the liquid salt prior to the distillation of the LiCl-KCl eutectic salt from the uranium deposits

  7. A multilayer concentric filter device to diminish clogging for separation of particles and microalgae based on size.

    Science.gov (United States)

    Chen, Chih-Chung; Chen, Yu-An; Liu, Yi-Ju; Yao, Da-Jeng

    2014-04-21

    Microalgae species have great economic importance; they are a source of medicines, health foods, animal feeds, industrial pigments, cosmetic additives and biodiesel. Specific microalgae species collected from the environment must be isolated for examination and further application, but their varied size and culture conditions make their isolation using conventional methods, such as filtration, streaking plate and flow cytometric sorting, labour-intensive and costly. A separation device based on size is one of the most rapid, simple and inexpensive methods to separate microalgae, but this approach encounters major disadvantages of clogging and multiple filtration steps when the size of microalgae varies over a wide range. In this work, we propose a multilayer concentric filter device with varied pore size and is driven by a centrifugation force. The device, which includes multiple filter layers, was employed to separate a heterogeneous population of microparticles into several subpopulations by filtration in one step. A cross-flow to attenuate prospective clogging was generated by altering the rate of rotation instantly through the relative motion between the fluid and the filter according to the structural design of the device. Mixed microparticles of varied size were tested to demonstrate that clogging was significantly suppressed due to a highly efficient separation. Microalgae in a heterogeneous population collected from an environmental soil collection were separated and enriched into four subpopulations according to size in a one step filtration process. A microalgae sample contaminated with bacteria and insect eggs was also tested to prove the decontamination capability of the device.

  8. CROSSCUTTING TECHNOLOGY DEVELOPMENT AT THE CENTER FOR ADVANCED SEPARATION TECHNOLOGIES

    Energy Technology Data Exchange (ETDEWEB)

    Christopher E. Hull

    2005-01-20

    The U.S. is the largest producer of mining products in the world. In 2003, U.S. mining operations produced $57 billion worth of raw materials that contributed a total of $564 billion to the nation's wealth. Despite these contributions, the mining industry has not been well supported with research and development funds as compared to mining industries in other countries. To overcome this problem, the Center for Advanced Separation Technologies (CAST) was established to develop technologies that can be used by the U.S. mining industry to create new products, reduce production costs, and meet environmental regulations. Much of the research to be conducted with Cooperative Agreement funds will be longer-term, high-risk, basic research and will be carried out in five broad areas: (1) Solid-solid separation; (2) Solid-liquid separation; (3) Chemical/Biological Extraction; (4) Modeling and Control; and (5) Environmental Control.

  9. Lab-on-fiber electrophoretic trace mixture separating and detecting an optofluidic device based on a microstructured optical fiber.

    Science.gov (United States)

    Yang, Xinghua; Guo, Xiaohui; Li, Song; Kong, Depeng; Liu, Zhihai; Yang, Jun; Yuan, Libo

    2016-04-15

    We report an in-fiber integrated electrophoretic trace mixture separating and detecting an optofluidic optical fiber sensor based on a specially designed optical fiber. In this design, rapid in situ separation and simultaneous detection of mixed analytes can be realized under electro-osmotic flow in the microstructured optical fiber. To visually display the in-fiber separating and detecting process, two common fluorescent indicators are adopted as the optofluidic analytes in the optical fiber. Results show that a trace amount of the mixture (0.15 μL) can be completely separated within 3.5 min under a high voltage of 5 kV. Simultaneously, the distributed information of the separated analytes in the optical fiber can be clearly obtained by scanning along the optical fiber using a 355 nm laser. The emission from the analytes can be efficiently coupled into the inner core and guides to the remote end of the optical fiber. In addition, the thin cladding around the inner core in the optical fiber can prevent the fluorescent cross talk between the analytes in this design. Compared to previous optical fiber optofluidic devices, this device first realizes simultaneously separating treatment and the detection of the mixed samples in an optical fiber. Significantly, such an in-fiber integrated separating and detecting optofluidic device can find wide applications in various analysis fields involves mixed samples, such as biology, chemistry, and environment.

  10. CROSSCUTTING TECHNOLOGY DEVELOPMENT AT THE CENTER FOR ADVANCED SEPARATION TECHNOLOGIES

    Energy Technology Data Exchange (ETDEWEB)

    Christopher E. Hull

    2005-11-04

    This Technical Progress Report describes progress made on the twenty nine subprojects awarded in the second year of Cooperative Agreement DE-FC26-02NT41607: Crosscutting Technology Development at the Center for Advanced Separation Technologies. This work is summarized in the body of the main report: the individual sub-project Technical Progress Reports are attached as Appendices.

  11. Crosscutting Technology Development at the Center for Advanced Separation Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Christopher E. Hull

    2006-09-30

    This Technical Progress Report describes progress made on the twenty nine subprojects awarded in the second year of Cooperative Agreement DE-FC26-02NT41607: Crosscutting Technology Development at the Center for Advanced Separation Technologies. This work is summarized in the body of the main report: the individual sub-project Technical Progress Reports are attached as Appendices.

  12. CROSSCUTTING TECHNOLOGY DEVELOPMENT AT THE CENTER FOR ADVANCED SEPARATION TECHNOLOGIES

    Energy Technology Data Exchange (ETDEWEB)

    Christopher E. Hull

    2006-05-15

    This Technical Progress Report describes progress made on the twenty nine subprojects awarded in the second year of Cooperative Agreement DE-FC26-02NT41607: Crosscutting Technology Development at the Center for Advanced Separation Technologies. This work is summarized in the body of the main report: the individual sub-project Technical Progress Reports are attached as Appendices.

  13. Development of a relatively cheap and simple automated separation system for a routine separation procedure based on extraction chromatography

    International Nuclear Information System (INIS)

    Petro Zoriy; Reinhold Flucht; Mechthild Burow; Peter Ostapczuk; Reinhard Lennartz; Myroslav Zoriy

    2010-01-01

    A robust analytical method has been developed in our laboratory for the separation of radionuclides by means of extraction chromatography using an automated separation system. The proposed method is both cheap and simple and provides the advantageous, rapid and accurate separation of the element of interest. The automated separation system enables a shorter separation time by maintaining a constant flow rate of solution and by avoiding clogging or bubbling in the chromatographic column. The present separation method was tested with two types of samples (water and urine) using UTEVA-, TRU- and Sr-specific resins for the separation of U, Th, Am, Pu and Sr. The total separation time for one radionuclide ranged from 60 to 100 min with the separation yield ranging from 68 to 98% depending on the elements separated. We used ICP-QMS, multi-low-level counter and alpha spectroscopy to measure the corresponding elements. (author)

  14. Studies on the effect of radio frequency field in a cusp-type charge separation device for direct energy conversion

    International Nuclear Information System (INIS)

    Hamabe, Masaki; Izawa, Hiroaki; Takeno, Hiromasa; Nakamoto, Satoshi; Ichimura, Kazuya; Nakashima, Yousuke

    2016-01-01

    In D- 3 He fusion power generation, an application of direct energy conversion is expected in which separation of charged particles is necessary. A cusp-type direct energy converter (CuspDEC) was proposed as a charge separation device, but its performance was degraded for a high density plasma. The goal of the present study is to establish an additional method to assist charge separation by using a nonlinear effect of a radio frequency (rf) electric field. Following to the previous study, we experimentally examine the effect of an rf field to electron motion in a CuspDEC device. Two ring electrodes were newly installed in a CuspDEC simulator and the current flowing into the electron collector located in the line cusp region was measured on an rf field application. The significant variation in the current was found, and an improvement of the charge separation can be expected by using the phenomenon appropriately. (author)

  15. [Development of new magnetic bead separation and purification instrument].

    Science.gov (United States)

    Xu, Yingyuan; Chen, Yi

    2014-05-01

    The article describes the development of new magnetic bead separation and purification instrument. The main application of the instrument is to capture tubercle bacillus from sputum. It is a pretreatment instrument and provides a new platform to help doctors to diagnose bacillary phthisis. Not only could it be used for tubercle bacillus capturing, but also for gene, protein and cell separating and purification. Because the controller of the instrument is 16-bit single chip microcomputer, the cost could be greatly reduced and it will be widely used in China.

  16. Development of O-18 stable isotope separation technology using membrane

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Woo; Kim, Taek Soo; Choi, Hwa Rim; Park, Sung Hee; Lee, Ki Tae; Chang, Dae Shik

    2006-06-15

    The ultimate goal of this investigation is to develop the separation technology for O-18 oxygen stable isotope used in a cyclotron as a target for production of radioisotope F-18. F-18 is a base material for synthesis of [F-18]FDG radio-pharmaceutical, which is one of the most important tumor diagnostic agent used in PET (Positron Emission Tomography). More specifically, this investigation is focused on three categories as follow, 1) development of the membrane distillation isotope separation process to re-enrich O-18 stable isotope whose isotopic concentration is reduced after used in a cyclotron, 2) development of organic impurity purification technology to remove acetone, methanol, ethanol, and acetonitrile contained in a used cyclotron O-18 enriched target water, and 3) development of a laser absorption spectroscopic system for analyzing oxygen isotopic concentration in water.

  17. An overview of copper-laser development for isotope separation

    International Nuclear Information System (INIS)

    Warner, B.E.

    1987-01-01

    We have developed a copper-laser pumped dye-laser system that addresses all of the requirements for atomic vapor laser isotope separation. The requirement for high average power for the laser system has led to the development of copper-laser chains with injection-locked oscillators and multihundred-watt amplifiers. By continuously operating the Laser Demonstration Facility, we gain valuable data for further upgrade and optimization

  18. Development of compact tritium confinement system using gas separation membrane

    International Nuclear Information System (INIS)

    Hayashi, Takumi; Okuno, Kenji

    1994-01-01

    In order to develop more compact and cost-effective tritium confinement system for fusion reactor, a new system using gas separation membranes has been studied at the Tritium Process Laboratory in the Japan Atomic Energy Research Institute. The preliminary result showed that the gas separation membrane system could reduce processing volume of tritium contaminated gas to more than one order of magnitude compared with the conventional system, and that most of tritiated water vapor (humidity) could be directly recovered by water condenser before passing through dryer such as molecular sieves. More detail investigations of gas separation characteristics of membrane were started to design ITER Atmospheric Detritiation System (ADS). Furthermore, a scaled polyimide membrane module (hollow-filament type) loop was just installed to investigate the actual tritium confinement performance under various ITER-ADS conditions. (author)

  19. Microfluidic devices for investigation of biomimetic membranes for sensor and separation applications

    DEFF Research Database (Denmark)

    Pszon-Bartosz, Kamila Justyna

    to microfluidic designs involving protein delivery to biomimetic membranes developed for sensor and separation applications. Finally, an OMP functionality modulation with β-cyclodextrin (β-CD) was shown and revealed the protein potential application as a sensor. Moreover, the β-CD blocker may be used to prevent...... for industrial applications. Among them are the inherent fragility of lipid membranes, the challenge of up-scaling the effective membrane area and the quantification of the protein delivery to the lipid membrane which may determined the biomimetic membrane application. This PhD thesis addresses the above...

  20. CROSSCUTTING TECHNOLOGY DEVELOPMENT AT THE CENTER FOR ADVANCED SEPARATION TECHNOLOGIES

    Energy Technology Data Exchange (ETDEWEB)

    Hugh W. Rimmer

    2004-05-12

    This Technical Progress Report describes progress made on the seventeen subprojects awarded in the first year of Cooperative Agreement DE-FC26-02NT41607: Crosscutting Technology Development at the Center for Advanced Separation Technologies. This work is summarized in the body of the main report: the individual sub-project Technical Progress Reports are attached as Appendices. Due to the time taken up by the solicitation/selection process, these cover the initial 6-month period of project activity only. The U.S. is the largest producer of mining products in the world. In 1999, U.S. mining operations produced $66.7 billion worth of raw materials that contributed a total of $533 billion to the nation's wealth. Despite these contributions, the mining industry has not been well supported with research and development funds as compared to mining industries in other countries. To overcome this problem, the Center for Advanced Separation Technologies (CAST) was established to develop technologies that can be used by the U.S. mining industry to create new products, reduce production costs, and meet environmental regulations. Originally set up by Virginia Tech and West Virginia University, this endeavor has been expanded into a seven-university consortium--Virginia Tech, West Virginia University, University of Kentucky, University of Utah, Montana Tech, New Mexico Tech and University of Nevada, Reno--that is supported through U.S. DOE Cooperative Agreement No. DE-FC26-02NT41607: Crosscutting Technology Development at the Center for Advanced Separation Technologies. Much of the research to be conducted with Cooperative Agreement funds will be longer-term, high-risk, basic research and will be carried out in five broad areas: (1) Solid-solid separation (2) Solid-liquid separation (3) Chemical/Biological Extraction (4) Modeling and Control, and (5) Environmental Control.

  1. Studies on the Effect of Radio Frequency Field in a Cusp-Type Charge Separation Device for Direct Energy Conversion

    OpenAIRE

    HAMABE, Masaki; IZAWA, Hiroaki; TAKENO, Hiromasa; NAKAMOTO, Satoshi; ICHIMURA, Kazuya; NAKASHIMA, Yousuke

    2016-01-01

    In D-3He fusion power generation, an application of direct energy conversion is expected in which separation of charged particles is necessary. A cusp-type direct energy converter (CuspDEC) was proposed as a charge separation device, but its performance was degraded for a high density plasma. The goal of the present study is to establish an additional method to assist charge separation by using a nonlinear effect of a radio frequency (rf) electric field. Following to the previous study, we ex...

  2. Development of new damping devices for piping

    International Nuclear Information System (INIS)

    Kobayashi, Hiroe

    1991-01-01

    An increase of the damping ratio is known to be very effective for the seismic design of a piping system. Increasing the damping ratio and reducing the seismic response of the piping system, the following three types of damping devices for piping systems are introduced: (1) visco-elastic damper, (2) elasto-plastic damper and (3) compact dynamic damper. The dynamic characteristics of these damping devices were investigated by the component test and the applicability of them to the piping system was confirmed by the vibration test using a three dimensional piping model. These damping devices are more effective than mechanical snubbers to reduce the vibration of the piping system. (author)

  3. Radiation Simulations and Development of Concepts for High Power Beam Dumps, Catchers and Pre-separator Area Layouts for the Fragment Separators for RIA

    CERN Document Server

    Ronningen, Reginald; Beene, James R; Blideanu, Valetin; Boles, Jason; Bollen, Georg; Burgess, Thomas; Carter, Ken; Conner, David L; Gabriel, Tony A; Geissel, Hans; Gomes, Itacil C; Heilbronn, Lawrence; Iwase, Hiroshi; Lawton, Don; Levand, Anthony; Mansur, Louis; Momozaki, Yoichi; Morrissey, David; Nolen, Jerry; Reed, Claude; Remec, Igor; Rennich, Mark; Reyes, Susana; Sherrill, Bradley; Stein, Werner; Stoyer, Mark; Stracener, Dan; Wendel, Mark; Zeller, Al

    2005-01-01

    The development of high-power beam dumps and catchers, and pre-separator layouts for proposed fragment separators of the Rare-Isotope Accelerator (RIA) facility are important in realizing how to handle the 400 kW in the primary beam. We will present examples of pre-conceptual designs of beam dumps, fragment catchers, and the pre-separator layout. We will also present examples of ongoing work on radiation simulations using the heavy-ion-transport code PHITS, characterizing the secondary radiation produced by the high-power ion beams interacting with these devices. Results on radiation heating of targets, magnet coils, associated hardware and shielding, component activation, and levels of radiation dose will be presented. These initial studies will yield insight into the impact of the high-power dissipation on fragment separator design, remote handling concepts, nuclear safety and potential facility hazard classification, shielding design, civil construction design, component design, and material choices. Furth...

  4. Recent developments in separation of low molecular weight heparin anticoagulants.

    Science.gov (United States)

    Sadowski, Radosław; Gadzała-Kopciuch, Renata; Buszewski, Bogusław

    2017-10-05

    The general function of anticoagulants is to prevent blood clotting and growing of the existing clots in blood vessels. In recent years, there has been a significant improvement in developing methods of prevention as well as pharmacologic and surgical treatment of thrombosis. For over the last two decades, low molecular weight heparins (LMWHs) have found their application in the antithrombotic diseases treatment. These types of drugs are widely used in clinical therapy. Despite the biological and medical importance of LMWHs, they have not been completely characterized in terms of their chemical structure. Due to both, the structural complexity of these anticoagulants and the presence of impurities, their structural characterization requires the employment of advanced analytical techniques. Since separation techniques play the key role in these endeavors, this review will focus on the presentation of recent developments in the separation of LMWH anticoagulants. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  5. Crosscutting Technology Development at the Center for Advanced Separation Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Christopher Hull

    2009-10-31

    The U.S. is the largest producer of mining products in the world. In 2003, U.S. mining operations produced $57 billion worth of raw materials that contributed a total of $564 billion to the nation's wealth. Despite these contributions, the mining industry has not been well supported with research and development funds as compared to mining industries in other countries. To overcome this problem, the Center for Advanced Separation Technologies (CAST) was established to develop technologies that can be used by the U.S. mining industry to create new products, reduce production costs, and meet environmental regulations. Originally set up by Virginia Tech and West Virginia University, this endeavor has been expanded into a seven-university consortium -- Virginia Tech, West Virginia University, University of Kentucky, University of Utah, Montana Tech, New Mexico Tech and University of Nevada, Reno - that is supported through U.S. DOE Cooperative Agreement No. DE-FC26-02NT41607: Crosscutting Technology Development at the Center for Advanced Separation Technologies. Much of the research to be conducted with Cooperative Agreement funds will be longer-term, high-risk, basic research and will be carried out in five broad areas: (1) Solid-solid separation; (2) Solid-liquid separation; (3) Chemical/biological extraction; (4) Modeling and control; and (5) Environmental control. Distribution of funds is handled via competitive solicitation of research proposals through Site Coordinators at the seven member universities. These were first reviewed and ranked by a group of technical reviewers (selected primarily from industry). Based on these reviews, and an assessment of overall program requirements, the CAST Technical Committee made an initial selection/ranking of proposals and forwarded these to the DOE/NETL Project Officer for final review and approval. The successful projects are listed by category, along with brief abstracts of their aims and objectives.

  6. Process and device for uranium isotope separation and application for the manufacture of chemical compounds or for the separation of gaseous mixtures otherwise difficult to separate

    International Nuclear Information System (INIS)

    Gregorius, K.; Janner, K.; Kersting, A.; Schuster, E.; Niemann, H.J.

    1987-01-01

    The U235/U238 isotope separation is done by laser excitation with Ur 6 as the initial gaseous material. This has HBr added as the partner for a chemical reaction, preferably in the ratio of 1:10. In order to increase the selectivity and yield, the two partners in the reaction are cooled by adiabatic expansion to below 100 K before irradiation. This makes the absorption bands narrower. The excitation occurs in the Q branch of the rotation vibration spectrum. (DG) [de

  7. Characteristics of isotope-selective chemical reactor with gas-separating device

    International Nuclear Information System (INIS)

    Gorshunov, N.M.; Kalitin, S.A.; Laguntsov, N.I.; Neshchimenko, Yu.P.; Sulaberidze, G.A.

    1988-01-01

    A study was made on characteristics of separating stage, composed of isotope-selective chemical (or photochemical) reactor and membrane separating cascade (MSC), designated for separation of isotope-enriched products from lean reagents. MSC represents the counterflow cascade for separation of two-component mixtures. Calculations show that for the process of carton isotope separation the electric power expences for MSC operation are equal to 20 kWxh/g of CO 2 final product at 13 C isotope content in it equal to 75%. Application of the membrane gas-separating cascade at rather small electric power expenses enables to perform cascading of isotope separation in the course of nonequilibrium chemical reactions

  8. Development of a Virtual Guitar using Haptic Device

    OpenAIRE

    田村,真晴; 山下,英生

    2009-01-01

    In recent years, a haptic device that output power as one of the computer output devices has been developed. We can get the feeling that we really touch the material through a sensor of haptic device when we touch a material simulated in a computer. In this research, a virtual guitar in which the feeling playing guitar and the sound volume are changed by adjusting power to input with a haptic device was developed. With the haptic device we feel as if we play a genuine guitar. Moreover, it see...

  9. Development of a wireless blood pressure measuring device with smart mobile device.

    Science.gov (United States)

    İlhan, İlhan; Yıldız, İbrahim; Kayrak, Mehmet

    2016-03-01

    Today, smart mobile devices (telephones and tablets) are very commonly used due to their powerful hardware and useful features. According to an eMarketer report, in 2014 there were 1.76 billion smartphone users (excluding users of tablets) in the world; it is predicted that this number will rise by 15.9% to 2.04 billion in 2015. It is thought that these devices can be used successfully in biomedical applications. A wireless blood pressure measuring device used together with a smart mobile device was developed in this study. By means of an interface developed for smart mobile devices with Android and iOS operating systems, a smart mobile device was used both as an indicator and as a control device. The cuff communicating with this device through Bluetooth was designed to measure blood pressure via the arm. A digital filter was used on the cuff instead of the traditional analog signal processing and filtering circuit. The newly developed blood pressure measuring device was tested on 18 patients and 20 healthy individuals of different ages under a physician's supervision. When the test results were compared with the measurements made using a sphygmomanometer, it was shown that an average 93.52% accuracy in sick individuals and 94.53% accuracy in healthy individuals could be achieved with the new device. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  10. Developing biomedical devices design, innovation and protection

    CERN Document Server

    Andreoni, Giuseppe; Colombo, Barbara

    2013-01-01

    During the past two decades incredible progress has been achieved in the instruments and devices used in the biomedical field. This progress stems from continuous scientific research that has taken advantage of many findings and advances in technology made available by universities and industry. Innovation is the key word, and in this context legal protection and intellectual property rights (IPR) are of crucial importance. This book provides students and practitioners with the fundamentals for designing biomedical devices and explains basic design principles. Furthermore, as an aid to the dev

  11. New Developments in Membrane-Based Chemical Separations

    National Research Council Canada - National Science Library

    Jirage, Kshama

    1998-01-01

    Membrane based chemical separations is an emerging field of research. This is because membrane-based separations are potentially less energy intensive and more cost effective than competing separation methods...

  12. Development and application of charcoal sorbents for cryopumping fusion devices

    Energy Technology Data Exchange (ETDEWEB)

    Sedgley, D.W. (Grumman Corp., Bethpage, NY (USA). Space Systems Div.)

    1989-06-01

    Progress has been made in defining the capabilities of charcoal as the most promising absorbent to be used in cryopumps for fusion power application. The capabilities of alternative methods of cryopumping helium have been examined in a literature survey and by test, and the results are described here. Considerations include pumping speed, capacity to accumulate pumped gas, ease of reconditioning, use of alternative materials and tolerance to the fusion environment. Vacuum pumps for future fusion devices must handle large quantities of helium/hydrogen isotopes and other impurities. Cryopumps or turbomolecular pumps have demonstrated the capability on a small scale, and each has an important advantage: TMPs do not accumulate gases; cryopumps can separate helium from other effluents. This paper includes a review of a method for selecting charcoals for helium cryopumping, testing of a continuously operating cryopump system, and definition of a design that is based on the requirements of the Next European Torus. Tritium limits are satisfied. The pump design incorporates the charcoal sorbent system that has been recently developed and is based on a reasonable extrapolation of current state-of-the-art. Evaluation of alternative methods of separating helium and other gases led to selection of a movable barrier as the preferred solution. (orig.).

  13. New Development of Membrane Base Optoelectronic Devices

    Directory of Open Access Journals (Sweden)

    Leon Hamui

    2017-12-01

    Full Text Available It is known that one factor that affects the operation of optoelectronic devices is the effective protection of the semiconductor materials against environmental conditions. The permeation of atmospheric oxygen and water molecules into the device structure induces degradation of the electrodes and the semiconductor. As a result, in this communication we report the fabrication of semiconductor membranes consisting of Magnesium Phthalocyanine-allene (MgPc-allene particles dispersed in Nylon 11 films. These membranes combine polymer properties with organic semiconductors properties and also provide a barrier effect for the atmospheric gas molecules. They were prepared by high vacuum evaporation and followed by thermal relaxation technique. For the characterization of the obtained membranes, Fourier-transform infrared spectroscopy (FT-IR, scanning electron microscopy (SEM, and energy dispersive spectroscopy (EDS were used to determine the chemical and microstructural properties. UV-ViS, null ellipsometry, and visible photoluminescence (PL at room temperature were used to characterize the optoelectronic properties. These results were compared with those obtained for the organic semiconductors: MgPc-allene thin films. Additionally, semiconductor membranes devices have been prepared, and a study of the device electronic transport properties was conducted by measuring electrical current density-voltage (J-V characteristics by four point probes with different wavelengths. The resistance properties against different environmental molecules are enhanced, maintaining their semiconductor functionality that makes them candidates for optoelectronic applications.

  14. Development of a plutonium ceramic target for the MASHA separator

    Energy Technology Data Exchange (ETDEWEB)

    Shaughnessy, D.A.; Moody, K.J.; Kenneally, J.M.; Wild, J.F.; Stoyer, M.A.; Lougheed, R.W.; Yeremin, A.V.; Oganessian, Yu.Ts

    2004-04-05

    We are participating in the development of the target for the MASHA (Mass Analyzer of Super Heavy Atoms) on-line mass separator in Dubna. Along with recent upgrades of the U400 cyclotron, MASHA will provide for at least a ten-fold increase in the production- and-detection rate for element 114 atoms, and will allow us to measure their atomic masses precisely. The MASHA separator will employ a thick Pu ceramic target capable of tolerating temperatures in the vicinity of 2000 C without vaporizing the actinide compound. Reaction products will diffuse out of the target and will drift to an ECR ion source after which they will be transported through the separator and will impinge on a position-sensitive focal-plane detector array. Furthermore, operation of the MASHA hot target/ion source combination will provide chemical volatility information that will support our assignment of an atomic number of 114 to these nuclei. Taken together, these experiments on MASHA will allow us to make measurements that will cement our identification of element 114 and provide for future experiments in which the chemical properties of the heaviest elements are studied.

  15. Development of a Plutonium Ceramic Target for the MASHA Separator

    Science.gov (United States)

    Shaughnessy, D. A.; Moody, K. J.; Kenneally, J. M.; Wild, J. F.; Stoyer, M. A.; Lougheed, R. W.; Yeremin, A. V.; Oganessian, Yu. Ts.

    2004-04-01

    We are participating in the development of the target for the MASHA (Mass Analyzer of Super Heavy Atoms) on-line mass separator in Dubna. Along with recent upgrades of the U400 cyclotron, MASHA will provide for at least a ten-fold increase in the production- and-detection rate for element 114 atoms, and will allow us to measure their atomic masses precisely. The MASHA separator will employ a thick Pu ceramic target capa- ble of tolerating temperatures in the vicinity of 2000 C without vaporizing the actinide compound. Reaction products will diffuse out of the target and will drift to an ECR ion source after which they will be transported through the separator and will impinge on a position-sensitive focal-plane detector array. Furthermore, operation of the MASHA hot target/ion source combination will provide chemical volatility information that will support our assignment of an atomic number of 114 to these nuclei. Taken together, these experiments on MASHA will allow us to make measurements that will cement our identification of element 114 and provide for future experiments in which the chemical properties of the heaviest elements are studied.

  16. Development of a plutonium ceramic target for the MASHA separator

    International Nuclear Information System (INIS)

    Shaughnessy, D.A.; Moody, K.J.; Kenneally, J.M.; Wild, J.F.; Stoyer, M.A.; Lougheed, R.W.; Yeremin, A.V.; Oganessian, Yu.Ts.

    2004-01-01

    We are participating in the development of the target for the MASHA (Mass Analyzer of Super Heavy Atoms) on-line mass separator in Dubna. Along with recent upgrades of the U400 cyclotron, MASHA will provide for at least a ten-fold increase in the production- and-detection rate for element 114 atoms, and will allow us to measure their atomic masses precisely. The MASHA separator will employ a thick Pu ceramic target capable of tolerating temperatures in the vicinity of 2000 C without vaporizing the actinide compound. Reaction products will diffuse out of the target and will drift to an ECR ion source after which they will be transported through the separator and will impinge on a position-sensitive focal-plane detector array. Furthermore, operation of the MASHA hot target/ion source combination will provide chemical volatility information that will support our assignment of an atomic number of 114 to these nuclei. Taken together, these experiments on MASHA will allow us to make measurements that will cement our identification of element 114 and provide for future experiments in which the chemical properties of the heaviest elements are studied

  17. Fast blood plasma separation device for point-of-care applications

    Czech Academy of Sciences Publication Activity Database

    Ďurč, P.; Foret, František; Kubáň, Petr

    2018-01-01

    Roč. 183, JUN (2018), s. 55-60 ISSN 0039-9140 Institutional support: RVO:68081715 Keywords : blood plasma separation * capillary electrophoresis * point of care analysis * methanol * metabolites Subject RIV: CB - Analytical Chemistry, Separation OBOR OECD: Analytical chemistry Impact factor: 4.162, year: 2016

  18. Novel highly integrated biodiesel production technology in a centrifugal contactor separator device

    NARCIS (Netherlands)

    Kraai, G. N.; Schuur, B.; van Zwol, F.; van de Bovenkamp, H. H.; Heeres, H. J.

    2009-01-01

    The base catalyzed production of biodiesel (FAME) from sunflower oil and methanol in a continuous centrifugal contactor separator (CCS) with integrated reaction and phase separation was studied. The effect of catalyst loading (sodium methoxide), temperature, rotational frequency and flow rates of

  19. A device for pre-separating water-drops in a two-phase flow

    International Nuclear Information System (INIS)

    Andro, Jean; Peyrelongue, J.-P.

    1974-01-01

    The invention relates to the mechanical pre-separation of water-drops in suspension in a flow of saturated steam. To this end, the method comprises the steps of carrying out rough separations by directing the flow towards curved surfaces adapted to deflect that flow and to project the drops onto said surfaces, sucking the film formed by the water-drops displaced by centrifugal force on the outer periphery of said surfaces, directing the steam separated from the water-drops onto five separators so as to extract dry steam and discharging the water provided by the sucking of said surfaces and the five separators. The invention applies to the drying of steam issuing from the high-pressure bodies of nuclear steam-turbines [fr

  20. Centrifugal Separation Device Based on Two-Layer Laminar Flow in Microchannels for High-Throughput and Continuous Blood Cell/Plasma Separation

    Science.gov (United States)

    Taizo Kobayashi,; Taisuke Funamoto,; Makoto Hosaka,; Satoshi Konishi,

    2010-07-01

    This paper presents a novel type of centrifugation device that is based on the two-layer laminar flow in micro flow channels for continuous blood cell/plasma separation. We propose to rotate the flow channels which are arranged along the circumference around the rotational axis. Downsizing the channel width reduced both the cell sedimentation time and the required centrifugal force, because the channel width corresponds to the centrifugal sedimentation length. First, plasma and cells were continuously extracted from pig blood in each of the branch channels using a milled acrylic prototype device (channel width = 800 μm, volume = 150 μl). Next, the relationship between the channel width (125, 250, and 500 μm) and the sedimentation time taken for various centrifugal forces (2.3, 9, 36, and 145 G) was evaluated using the downsized microchannels fabricated by hot-embossing and thermal bonding technologies. Using downsized microchannels with a width of 125 μm successfully reduced the sedimentation time to 85 s as compared to the sedimentation time of 270 s for a channel of a width of 500 μm, when a centrifugal force of 2.3 G was applied. The use of the proposed device did not result in obvious hemolysis at the centrifugal forces lower than 335 G.

  1. Separation setup for the light water detritiation process in the water-hydrogen system based on the membrane contact devices

    International Nuclear Information System (INIS)

    Rozenkevich, M. B.; Rastunova, I. L.; Prokunin, S. V.

    2008-01-01

    Detritiation of light water wastes down to a level permissible to discharge into the environment while simultaneously concentrating tritium to decrease amount of waste being buried is a constant problem. The laboratory setup for the light water detritiation process is presented. The separation column consists of 10 horizontally arranged perfluorosulphonic acid Nafion-type membrane contact devises and platinum catalyst (RCTU-3SM). Each contact device has 42.3 cm 2 of the membrane and 10 cm 3 of the catalyst. The column is washed by tritium free light water (L H2O ) and the tritium-containing flow (F HTO ) feeds the electrolyser at λ = G H2 /L H2O = 2. A separation factor of 66 is noted with the device at 336 K and 0.145 MPa. (authors)

  2. Cybersecurity and the Medical Device Product Development Lifecycle.

    Science.gov (United States)

    Jones, Richard W; Katzis, Konstantinos

    2017-01-01

    Protecting connected medical devices from evolving cyber related threats, requires a continuous lifecycle approach whereby cybersecurity is integrated within the product development lifecycle and both complements and re-enforces the safety risk management processes therein. This contribution reviews the guidance relating to medical device cybersecurity within the product development lifecycle.

  3. Recent developments in drug eluting devices with tailored interfacial properties.

    Science.gov (United States)

    Sanchez-Rexach, Eva; Meaurio, Emilio; Sarasua, Jose-Ramon

    2017-11-01

    Drug eluting devices have greatly evolved during past years to become fundamental products of great marketing importance in the biomedical field. There is currently a large diversity of highly specialized devices for specific applications, making the development of these devices an exciting field of research. The replacement of the former bare metal devices by devices loaded with drugs allowed the sustained and controlled release of drugs, to achieve the desired local therapeutic concentration of drug. The newer devices have been "engineered" with surfaces containing micro- and nanoscale features in a well-controlled manner, that have shown to significantly affect cellular and subcellular function of various biological systems. For example, the topography can be structured to form an antifouling surface mimicking the defense mechanisms found in nature, like the skin of the shark. In the case of bone implants, well-controlled nanostructured interfaces can promote osteoblast differentiation and matrix production, and enhance short-term and long-term osteointegration. In any case, the goal of current research is to design implants that induce controlled, guided, and rapid healing. This article reviews recent trends in the development of drug eluting devices, as well as recent developments on the micro/nanotechnology scales, and their future challenges. For this purpose medical devices have been divided according to the different systems of the body they are focused to: orthopedic devices, breathing stents, gastrointestinal and urinary systems, devices for cardiovascular diseases, neuronal implants, and wound dressings. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Separations technologies supporting the development of a deployable ATW system

    International Nuclear Information System (INIS)

    Laidler, J. J.

    2000-01-01

    A program has been initiated for the purpose of developing the chemical separations technologies necessary to support a large Accelerator Transmutation of Waste (ATW) system capable of dealing with the projected inventory of spent fuel from the commercial nuclear power stations in the United States. The first several years of the program will be directed toward an elucidation of related technical issues and to the establishment, by means of comprehensive trade studies, of an optimum configuration of the elements of the chemical processing infrastructure required for support of the total ATW system. By adopting this sort of disciplined systems engineering approach, it is expected that development and demonstration costs can be minimized and that it will be possible to deploy an ATW system that is an environmentally sound and economically viable venture

  5. Wearable Device Control Platform Technology for Network Application Development

    Directory of Open Access Journals (Sweden)

    Heejung Kim

    2016-01-01

    Full Text Available Application development platform is the most important environment in IT industry. There are a variety of platforms. Although the native development enables application to optimize, various languages and software development kits need to be acquired according to the device. The coexistence of smart devices and platforms has rendered the native development approach time and cost consuming. Cross-platform development emerged as a response to these issues. These platforms generate applications for multiple devices based on web languages. Nevertheless, development requires additional implementation based on a native language because of the coverage and functions of supported application programming interfaces (APIs. Wearable devices have recently attracted considerable attention. These devices only support Bluetooth-based interdevice communication, thereby making communication and device control impossible beyond a certain range. We propose Network Application Agent (NetApp-Agent in order to overcome issues. NetApp-Agent based on the Cordova is a wearable device control platform for the development of network applications, controls input/output functions of smartphones and wearable/IoT through the Cordova and Native API, and enables device control and information exchange by external users by offering a self-defined API. We confirmed the efficiency of the proposed platform through experiments and a qualitative assessment of its implementation.

  6. Efficient separations and processing crosscutting program: Develop and test sorbents

    International Nuclear Information System (INIS)

    Bray, L.A.

    1995-09-01

    This report summarizes work performed during FY 1995 under the task open-quotes Develop and Test Sorbents,close quotes the purpose of which is to develop high-capacity, selective solid extractants to recover cesium, strontium, and technetium from nuclear wastes. This work is being done for the Efficient Separations and Processing Crosscutting Program (ESP), operated by the U.S. Department of Energy's Office of Environmental Management's Office of Technology Development. The task is under the direction of staff at Pacific Northwest Laboratory (PNL) with key participation from industrial and university staff at 3M, St. Paul, Minnesota; IBC Advanced Technologies, Inc., American Forks, Utah; AlliedSignal, Inc., Des Plaines, Illinois, and Texas A ampersand M University, College Station, Texas. 3M and IBC are responsible for ligand and membrane technology development; AlliedSignal and Texas A ampersand M are developing sodium titanate powders; and PNL is testing the materials developed by the industry/university team members. Major accomplishments for FY 1995 are summarized in this report

  7. Computational Study of Separation Control Using ZNMF Devices: Flow Physics and Scaling Laws

    National Research Council Canada - National Science Library

    Mittal, Rajat

    2008-01-01

    The primary objective of the proposed research was to gain a fundamental understanding of strategies, mechanisms, and scaling laws for successful control of separation using zern-net mass-flux (ZNMF) actuators...

  8. Printed energy storage devices by integration of electrodes and separators into single sheets of paper

    KAUST Repository

    Hu, Liangbing; Wu, Hui; Cui, Yi

    2010-01-01

    We report carbon nanotube thin film-based supercapacitors fabricated with printing methods, where electrodes and separators are integrated into single sheets of commercial paper. Carbon nanotube films are easily printed with Meyer rod coating or ink

  9. Separation nozzle: an aerodynamic device for large-scale enrichment of uranium-235

    International Nuclear Information System (INIS)

    Becker, E.W.; Bley, P.; Ehrfeld, U.; Ehrfeld, W.

    1977-01-01

    This paper gives a review of the flow and diffusion phenomena in the separation nozzle. It is shown that admixing of a light auxiliary gas offers inherent advantages for the separation of heavy isotopic molecules in a centrifugal flow. The UF 6 is accelerated to a high speed ratio by the light gas already at a low expansion of the mixture--i.e., favorable conditions for centrifugal separation are obtained while aerodynamic losses are kept low. In addition, isotope separation is enhanced because of the different diffusion velocities of the isotopes relative to the light gas. Typical rarefaction phenomena are observed in the curved jet; the molecular velocity distribution is bimodal in large regions of the flow, and a velocity slip between the heavy UF 6 and the light auxiliary gas occurs

  10. Legislative aspects of the development of medical devices.

    Science.gov (United States)

    Marešová, Petra; Klímová, Blanka; Krejcar, Ondřej; Kuča, Kamil

    2015-09-01

    European industry of medical device technologies represents 30% of all worlds sales. New health technologies bring effective treatment approaches, help shorten stays in hospital1),bring better treatment results and accelerate rehabilitation which leads to the earlier patients recovery.Legislative aspects are one of the key areas influencing the speed of development of medical devices and their launching. The aim of this article is to specify current state of legislation in the development of medical devices in the European Union in comparison with the market leaders such as China, Japan and USA.The best established market of medical devices is in the USA. Both Japan and China follow the USA model. However, a non-professional code of ethics in China in some respect contributes to the decrease of quality of medical devices, while Japan as well as the EU countries try really hard to conform to all the regulations imposed on the manufacturing of medical devices.

  11. Using a Microfluidic-Microelectric Device to Directly Separate Serum/Blood Cells from a Continuous Whole Bloodstream Flow

    Science.gov (United States)

    Wang, Ming-Wen; Jeng, Kuo-Shyang; Yu, Ming-Che; Su, Jui-Chih

    2012-03-01

    To make the rapid separation of serum/blood cells possible in a whole bloodstream flow without centrifugation and Pasteur pipette suction, the first step is to use a microchannel to transport the whole bloodstream into a microdevice. Subsequently, the resulting serum/blood cell is separated from the whole bloodstream by applying other technologies. Creating the serum makes this subsequent separation possible. To perform the actual separation, a microchannel with multiple symmetric curvilinear microelectrodes has been designed on a glass substrate and fabricated with micro-electromechanical system technology. The blood cells can be observed clearly by black-field microscopy imaging. A local dielectrophoretic (DEP) force, obtained from nonuniform electric fields, was used for manipulating and separating the blood cells from a continuous whole bloodstream. The experimental studies show that the blood cells incur a local dielectrophoretic field when they are suspended in a continuous flow (v = 0.02-0.1 cm/s) and exposed to AC fields at a frequency of 200 kHz. Using this device, the symmetric curvilinear microelectrodes provide a local dielectrophoretic field that is sufficiently strong for separating nearby blood cells and purifying the serum in a continuous whole bloodstream flow.

  12. A continuous flow micro filtration device for plasma/blood separation using submicron vertical pillar gap structures

    International Nuclear Information System (INIS)

    Kang, Tae Goo; Ji, Hongmiao; Lim, Pei Yi; Chen, Yu; Yoon, Yong-Jin

    2014-01-01

    This work demonstrates a continuous flow plasma/blood separator using a vertical submicron pillar gap structure. The working principle of the proposed separator is based on size exclusion of cells through cross-flow filtration, in which only plasma is allowed to pass through submicron vertical pillars located tangential to the main flow path of the blood sample. The maximum filtration efficiency of 99.9% was recorded with a plasma collection rate of 0.67 µl min −1 for an input blood flow rate of 12.5 µl min −1 . The hemolysis phenomenon was observed for an input blood flow rate above 30 µl min −1 . Based on the experimental results, we can conclude that the proposed device shows potential for the application of on-chip plasma/blood separation as a part of integrated point-of-care (POC) diagnostics systems. (technical note)

  13. Development of injection moulded, ultrasonically welded immiscible phase filtration devices

    DEFF Research Database (Denmark)

    Kistrup, Kasper

    for ultrasonic welding, suitable for microfluidic systems. A methodology has been established where energy directors can be quickly added to existing mould inserts, using laser micromachining. The produced device was performance tested by isolating methicillin-resistant Staphylococcus aureus from bovine whole....... The device appliesmagnetic bead-based solid-phase extraction for nucleic acid extraction from biological samples, using the immiscible phase filtration (IPF) approach. Device development has employed injection moulding for part fabrication and ultrasonic welding for bonding. Rapid prototyping...

  14. Application of a particle separation device to reduce inductively coupled plasma-enhanced elemental fractionation in laser ablation-inductively coupled plasma-mass spectrometry

    International Nuclear Information System (INIS)

    Guillong, Marcel; Kuhn, Hans-Rudolf; Guenther, Detlef

    2003-01-01

    The particle size distribution of laser ablation aerosols are a function of the wavelength, the energy density and the pulse duration of the laser, as well as the sample matrix and the gas environment. Further the size of the particles affects the vaporization and ionization efficiency in the inductively coupled plasma (ICP). Some matrices produce large particles, which are not completely vaporized and ionized in the ICP. The previous work has shown that analytical results such as matrix-independent calibration, accuracy and precision can be significantly influenced by the particle sizes of the particles. To minimize the particle size related incomplete conversion of the sample to ions in the ICP a particle separation device was developed, which allows effective particle separation using centrifugal forces in a thin coiled tube. In this device, the particle cut-off size is varied by changing the number of turns in the coil, as well as by changing the gas flow and the tube diameter. The interaction of the laser with the different samples leads to varying particle size distributions. When carrying out quantitative analysis with non-matrix matched calibration reference materials, it was shown that different particle cut-off sizes were required depending on the ICP conditions and the instrument used for analysis. Various sample materials were investigated in this study to demonstrate the applicability of the device. For silicate matrices, the capability of the ICP to produce ions was significantly reduced for particles larger than 0.5 μm, and was dependent on the element monitored. To reduce memory effects caused by the separated particles, a washout procedure was developed, which additionally allowed the analysis of the trapped particles. These results clearly demonstrate the very important particle size dependent ICP-MS signal response and the potential of the described particle size based separator for the reduction of ICP induced elemental fractionation

  15. Unmanned Aerial System Four-Dimensional Gunnery Training Device Development

    Science.gov (United States)

    2017-10-01

    Aerial System (UAS) Four-Dimensional Gunnery Training Device: Training Effectiveness Assessment (James & Miller, in press). 31 Technical ...Research Product 2018-05 Unmanned Aerial System Four-Dimensional Gunnery Training Device Development David R. James...for the Department of the Army by Northrop Grumman Corporation. Technical review by Thomas Rhett Graves, Ph.D., U.S. Army Research Institute

  16. Development of a Soundproof Device for 950 Watt rated Portable ...

    African Journals Online (AJOL)

    The noise emanating from generators has adverse effects on our health. In view of this, this paper reports the development of soundproof device for 950Watt rated generators which are widely used portable generators. Performance evaluation of the soundproof device was carried out, and the sound pressure level of the ...

  17. Process and device for separating a gaseous mixture from isotope compounds

    International Nuclear Information System (INIS)

    Gajewski, W.

    1980-01-01

    The UF 6 -gas mixture is adiabatically expanded through a nozzle and cooled to below 100 K. The emerging gas mixture beam is then totally taken up by radiation technology by a large number of sequentially ignited pulsed lasers of the same or different frequencies. The selective initiation and chemical or physical separation takes place along a path 2 cm long. (DG) [de

  18. Development of an integrated pointing device driver for the disabled.

    Science.gov (United States)

    Shih, Ching-Hsiang; Shih, Ching-Tien

    2010-01-01

    To help people with disabilities such as those with spinal cord injury (SCI) to effectively utilise commercial pointing devices to operate computers. This study proposes a novel method to integrate the functions of commercial pointing devices. Utilising software technology to develop an integrated pointing device driver (IPDD) for a computer operating system. The proposed IPDD has the following benefits: (1) it does not require additional hardware cost or circuit preservations, (2) it supports all standard interfaces of commercial pointing devices, including PS/2, USB and wireless interfaces and (3) it can integrate any number of devices. The IPDD can be selected and combined according to their physical restriction. The IPDD is a novel method of integrating commercial pointing devices. Through IPDD, people with disabilities can choose a suitable combination of commercial pointing devices to achieve full cursor control and optimise operational performance. In contrast with previous studies, the software-based solution does not require additional hardware or circuit preservations, and it can support unlimited devices. In summary, the IPDD has the benefits of flexibility, low cost and high-device compatibility.

  19. Filtration device for rapid separation of biological particles from complex matrices

    Science.gov (United States)

    Kim, Sangil; Naraghi-Arani, Pejman; Liou, Megan

    2018-01-09

    Methods and systems for filtering of biological particles are disclosed. Filtering membranes separate adjacent chambers. Through osmotic or electrokinetic processes, flow of particles is carried out through the filtering membranes. Cells, viruses and cell waste can be filtered depending on the size of the pores of the membrane. A polymer brush can be applied to a surface of the membrane to enhance filtering and prevent fouling.

  20. Uses of the Sonicguide as a Concept Development Device.

    Science.gov (United States)

    Vopata, Alvin E.

    1978-01-01

    The article discusses the Sonicguide, and electronic mobility device for the blind, and makes some suggestions for its introduction to young children and for its use as an aid in the development of spatial concepts. (Author/DLS)

  1. Cross-Platform Development Techniques for Mobile Devices

    Science.gov (United States)

    2013-09-01

    solutions. Mobile devices run on diverse platforms requiring differing constraints that the developer must adhere to. Thus, extra time and resources...and growing market for providing solutions. Mobile devices run on diverse platforms requiring differing constraints that the developer must adhere...testing are an iOS- based Apple iPhone 4 and an Android-based Samsung Galaxy S III. For user interface analysis this chapter also includes, from both

  2. Development and optimization of a device for diferencial pressure measurement

    International Nuclear Information System (INIS)

    Santarine, G.A.

    1980-01-01

    The measurements of reduced values of diferencial pressure, are studied. Several situations are described where the diferencial pressure accurate measurement is necessary in routine works in the Thermohydraulic Laboratory, as well as, the major pressure measurement devices and their respective range are studied. The development of a device for diferencial pressure measurement followed by the design development of the calibration bench covering the foreseen range, start up tests realization, optimization, calibration, performance analysis and conclusions, is showed. (Author) [pt

  3. Advanced-laser development for isotope separation. Final report

    International Nuclear Information System (INIS)

    1983-06-01

    To address a number of the issues associated with lasers appropriate for both atomic vapor and molecular laser enrichment schemes, MSNW developed pertinent technologies on two test devices. These were a high pulse rate, 100 watt excimer laser named Mistral, and a 20 watt copper-vapor laser (CVL). Mistral is a closed-loop, 100 W, kilohertz rare-gas halide laser system. The first half of the Mistral effort dealt with the study of gas flow and acoustic effects in high PRF rare-gas halide lasers. In burst-mode operation, 1250 Hz operation was demonstrated, the effects on flow quality of acoustic dampers were measured, and gas clearing factors of 2.5 at 1 kHz were demonstrated. The second half of the Mistral program dealt with extending the run time capability of the laser. This effort culminated with the continuous operation of Mistral for almost eight hours at 500 ppS, producing over 50 mJ/pulse at 308 nm on a single fill of XeCl gas mixture. At the end of the program, the effectiveness of using magnetic pulse compression in the modulator circuit of a copper-vapor laser (CVL) was also verified. The magnetic switching/pulse compression scheme as used on both the CVL and Mistral greatly extends thyratron lifetime

  4. Trends in remote handling device development

    International Nuclear Information System (INIS)

    Raimondi, T.

    1991-01-01

    A brief review is given of studies on layouts and methods for handling some major components requiring remote maintenance in future fusion reactors: Neutral sources and beam lines, the blanket, divertor plates, armour tiles and vacuum pumps. Comparison is made to problems encountered in JET, methods and equipment used and development work done there. Areas requiring development and research are outlined. These include topics which are the subject of papers presented here, such as dynamic studies and control of transporters, improvements to the man-machine interface and hot cell equipment. A variety of other topics where effort is needed are also mentioned: Environmental tolerance of components and equipment, TV viewing and compensation of viewing difficulties with aids such as computer graphics and image processing, safety assessment, computer aids for remote manipulation, remote cutting and welding techniques, routine in-vessel inspection methods and selection of connectors and flanges for remote handling. (orig.)

  5. Development of Implantable Medical Devices: From an Engineering Perspective

    Directory of Open Access Journals (Sweden)

    Yeun-Ho Joung

    2013-09-01

    Full Text Available From the first pacemaker implant in 1958, numerous engineering and medical activities for implantable medical device development have faced challenges in materials, battery power, functionality, electrical power consumption, size shrinkage, system delivery, and wireless communication. With explosive advances in scientific and engineering technology, many implantable medical devices such as the pacemaker, cochlear implant, and real-time blood pressure sensors have been developed and improved. This trend of progress in medical devices will continue because of the coming super-aged society, which will result in more consumers for the devices. The inner body is a special space filled with electrical, chemical, mechanical, and marine-salted reactions. Therefore, electrical connectivity and communication, corrosion, robustness, and hermeticity are key factors to be considered during the development stage. The main participants in the development stage are the user, the medical staff, and the engineer or technician. Thus, there are three different viewpoints in the development of implantable devices. In this review paper, considerations in the development of implantable medical devices will be presented from the viewpoint of an engineering mind.

  6. Component framework support for developing device drivers

    OpenAIRE

    Michiels, Sam; Kenens, Peter; Matthijs, Frank; Walravens, Dirk; Berbers, Yolande; Verbaeten, Pierre

    2000-01-01

    In this paper, we advocate the use of component framework technology for developing state-of-the-art system software. Relevant contributions of DiPS (Distrinet Protocol Stack), a component framework, include its anonymous interaction model, connectors for handling non-functional issues such as the concurrency model, and builder support. DiPS has effectively been used in industrial protocol stacks. This paper shows how we are using the DiPS component framework to build and support flexib...

  7. Practice of Regulatory Science (Development of Medical Devices).

    Science.gov (United States)

    Niimi, Shingo

    2017-01-01

    Prototypes of medical devices are made in accordance with the needs of clinical practice, and for systems required during the initial process of medical device development for new surgical practices. Verification of whether these prototypes produce the intended performance specifications is conducted using basic tests such as mechanical and animal tests. The prototypes are then improved and modified until satisfactory results are obtained. After a prototype passes through a clinical trial process similar to that for new drugs, application for approval is made. In the approval application process, medical devices are divided into new, improved, and generic types. Reviewers judge the validity of intended use, indications, operation procedures, and precautions, and in addition evaluate the balance between risk and benefit in terms of efficacy and safety. Other characteristics of medical devices are the need for the user to attain proficiency in usage techniques to ensure efficacy and safety, and the existence of a variety of medical devices for which assessment strategies differ, including differences in impact on the body in cases in which a physical burden to the body or failure of a medical device develops. Regulatory science of medical devices involves prediction, judgment, and evaluation of efficacy, safety, and quality, from which data result which can become indices in the development stages from design to application for approval. A reduction in the number of animals used for testing, improvement in efficiency, reduction of the necessity for clinical trials, etc. are expected through rational setting of evaluation items.

  8. Development of failure-detecting device for γ radioimmunoassay counter

    International Nuclear Information System (INIS)

    Shao Xianzhi; Zhang Bingfeng

    1997-01-01

    A failures-detecting device based on single chip microcomputer technique for detecting of failures of γ radioimmunoassay counter is developed. The device can output signals of variable amplitude and frequency similar to the pulse of γ particle for shooting problem parts of γ counter's detecting system. By automatically comparing the shapes and amplitudes of the two signals to and from an amplifier unit, the device can distinguish if the amplifier unit works normally. The differential-input amplifier circuit gives 0.1% accuracy for the measurement of the stability of high voltage. The pulse widen circuit of this device allows for middle speed A/D detecting of periodical low-frequency pulse waves of micro-second width. This device is used specifically for the maintaining and failure-detecting of γ radioimmunoassay counter

  9. A cost-effective device for the rapid transfer of gel-separated proteins onto membranes.

    Science.gov (United States)

    Tam, Hann W; Huang, Yu-Chen; Tam, Ming F

    2009-03-01

    We describe here the fabrication of a cost-effective semi-dry blotting apparatus for the transfer of proteins onto membranes. Graphite sheets were used as electrodes. Protein mixtures were separated on NuPAGE 4% to 12% polyacrylamide gradient gels. With a Tris-bicine buffer, we demonstrated that close to 80% of the proteins with apparent molecular mass of 80kDa or less were removed from the gels after 8min of blotting. The process is much faster than the techniques reported previously in the literature.

  10. Printed energy storage devices by integration of electrodes and separators into single sheets of paper

    Science.gov (United States)

    Hu, Liangbing; Wu, Hui; Cui, Yi

    2010-05-01

    We report carbon nanotube thin film-based supercapacitors fabricated with printing methods, where electrodes and separators are integrated into single sheets of commercial paper. Carbon nanotube films are easily printed with Meyer rod coating or ink-jet printing onto a paper substrate due to the excellent ink absorption of paper. A specific capacity of 33 F/g at a high specific power of 250 000 W/kg is achieved with an organic electrolyte. Such a lightweight paper-based supercapacitor could be used to power paper electronics such as transistors or displays.

  11. Printed energy storage devices by integration of electrodes and separators into single sheets of paper

    KAUST Repository

    Hu, Liangbing

    2010-01-01

    We report carbon nanotube thin film-based supercapacitors fabricated with printing methods, where electrodes and separators are integrated into single sheets of commercial paper. Carbon nanotube films are easily printed with Meyer rod coating or ink-jet printing onto a paper substrate due to the excellent ink absorption of paper. A specific capacity of 33 F/g at a high specific power of 250 000 W/kg is achieved with an organic electrolyte. Such a lightweight paper-based supercapacitor could be used to power paper electronics such as transistors or displays. © 2010 American Institute of Physics.

  12. Medical device development: managing conflicts of interest encountered by physicians.

    Science.gov (United States)

    Baim, Donald S; Donovan, Aine; Smith, John J; Briefs, Nancy; Geoffrion, Richard; Feigal, David; Kaplan, Aaron V

    2007-04-01

    New technologies introduced over the past three decades have transformed medical diagnosis and treatment, and significantly improved patient outcomes. These changes have been mediated by the introduction of new medical devices, particularly for the treatment of cardiovascular, orthopedic, and ophthalmic disorders. These devices, in turn, have created large markets and spawned a burgeoning medical device industry, including six Fortune 500 companies whose combined market capitalization now exceeds 400 billion dollars. This success story, which has unquestionably benefited patients and society alike, has been dependent upon an intense collaboration among industry, clinicians, and regulatory authorities. However, when physicians actively involved in patient care participate in such collaborations, they are increasingly vulnerable to creating potential conflicts between these two (clinical and device development) roles. Such conflicts, which may ultimately erode public trust, have important consequences not only for the individual physicians, but also for their parent institutions, their patients, sponsoring companies, and the entire clinical research enterprise that makes the development and introduction of new devices possible. The third Dartmouth Device Development Symposium held in October 2005 brought together thought leaders within the medical device community, including academicians, clinical investigators, regulators from the Food and Drug Administration and Centers for Medicare and Medicaid Services (CMS), large and small device manufacturers and the financial (venture capital and investment banks) community. The Symposium examined the conflicts of interest encountered during the early development and commercialization of a medical device. The goal of these discussions was to (1) identify and characterize the conflicts that arise and (2) provide strategies to address these conflicts. This manuscript was prepared by a writing committee to provide a summary

  13. Development of thin film inorganic membranes for oxygen separation

    Energy Technology Data Exchange (ETDEWEB)

    Moon, Hyo Jeong

    2012-08-22

    Membrane-based gas separation systems are noteworthy among technological options for carbon capture and storage (CCS), which is an important strategy to reduce CO{sub 2} emitted from point sources, e.g. mainly fossil power plants. In Oxyfuel-Combustion and Pre-Combustion of CCS power plant concepts oxygen separation from air is required. To meet this requirement oxygen transport membranes (OTM) consisting of gastight mixed ionic electronic conductors (MIEC) are proposed, which are associated with significantly lower efficiency losses compared with conventional air separation technologies. For cost effective application a maximum oxygen flux has to be achieved to reduce the membrane area. This can be met by reduction of membrane thickness. Therefore, the reduction of the membrane thickness to the micrometer range or even below is aimed in the present thesis. Ce{sub 0.8}Gd{sub 0.2}O{sub 2-{delta}} (CGO) with fluorite crystal structure and La{sub 0.58}Sr{sub 0.4}Co{sub 0.2}Fe{sub 0.8}O{sub 3-{delta}} (LSCF) with perovskite crystal structure were developed as thin film membrane. CGO is expected to be more stable than other potential MIEC membranes in reducing atmospheres and to achieve sufficient oxygen permeation, e.g. in syngas production or petrol chemistry. LSCF is expected to be highly permeable with an acceptable chemical stability in Oxyfuel-combustion. Various porous ceramic substrates were prepared by vacuum-slip-casting and warm-pressing, and then characterized for porosity, gas-permeability and surface roughness. Subsequently, two approaches to fabrication of thin film membranes were investigated, which are wetchemical deposition (WCD) and physical vapor deposition (PVD). For WCD, nano-dispersions and colloidal sols were prepared for membrane top-layer and/or interlayer. When CGO nano-dispersion (NDCGO) was spin-coated as thin film membrane, the gastightness of sintered membranes was increased with decrease in spinning time and increase in concentration of

  14. Membrane separation systems---A research and development needs assessment

    Energy Technology Data Exchange (ETDEWEB)

    Baker, R.W. (Membrane Technology and Research, Inc., Menlo Park, CA (USA)); Cussler, E.L. (Minnesota Univ., Minneapolis, MN (USA). Dept. of Chemical Engineering and Materials Science); Eykamp, W. (California Univ., Berkeley, CA (USA)); Koros, W.J. (Texas Univ., Austin, TX (USA)); Riley, R.L. (Separation Systems Technology, San Diego, CA (USA)); Strathmann, H. (Fraunhofer-Institut fuer Grenzflaech

    1990-04-01

    Industrial separation processes consume a significant portion of the energy used in the United States. A 1986 survey by the Office of Industrial Programs estimated that about 4.2 quads of energy are expended annually on distillation, drying and evaporation operations. This survey also concluded that over 0.8 quads of energy could be saved in the chemical, petroleum and food industries alone if these industries adopted membrane separation systems more widely. Membrane separation systems offer significant advantages over existing separation processes. In addition to consuming less energy than conventional processes, membrane systems are compact and modular, enabling easy retrofit to existing industrial processes. The present study was commissioned by the Department of Energy, Office of Program Analysis, to identify and prioritize membrane research needs in light of DOE's mission. Each report will be individually cataloged.

  15. Development of an innovative device for ultrasonic elliptical vibration cutting.

    Science.gov (United States)

    Zhou, Ming; Hu, Linhua

    2015-07-01

    An innovative ultrasonic elliptical vibration cutting (UEVC) device with 1st resonant mode of longitudinal vibration and 3rd resonant mode of bending vibration was proposed in this paper, which can deliver higher output power compared to previous UEVC devices. Using finite element method (FEM), resonance frequencies of the longitudinal and bending vibrations were tuned to be as close as possible in order to excite these two vibrations using two-phase driving voltages at a single frequency, while wave nodes of the longitudinal and bending vibrations were also adjusted to be as coincident as possible for mounting the device at a single fixed point. Based on the simulation analysis results a prototype device was fabricated, then its vibration characteristics were evaluated by an impedance analyzer and a laser displacement sensor. With two-phase sinusoidal driving voltages both of 480 V(p-p) at an ultrasonic frequency of 20.1 kHz, the developed prototype device achieved an elliptical vibration with a longitudinal amplitude of 8.9 μm and a bending amplitude of 11.3 μm. The performance of the developed UEVC device is assessed by the cutting tests of hardened steel using single crystal diamond tools. Experimental results indicate that compared to ordinary cutting process, the tool wear is reduced significantly by using the proposed device. Copyright © 2015 Elsevier B.V. All rights reserved.

  16. Development of mechanical circulatory support devices in China.

    Science.gov (United States)

    Wang, Wei; Zhu, De-Ming; Ding, Wen-Xiang

    2009-11-01

    Myocardial dysfunction leading to low cardiac output syndrome is a common clinical pathophysiological state. Currently, the use of mechanical circulatory support (MCS) is an essential aspect of the treatment of patients with cardiac failure. Several groups in China are engaged in the design and development of MCS devices. These devices can be classified as pulsatile, rotary, and total artificial heart (TAH). There are two types of pulsatile pump, which are driven by air (pneumatic). One of these pumps, the Luo-Ye pump, has been used clinically for short-term support since 1998. The other is a push-plate left ventricular device, which has a variable rate mode. Various rotary devices are classified into axial and centrifugal pumps, depending on the impeller geometry. Most rotary pumps are based on the maglev principle, and some types have been used clinically. Others are still being studied in the laboratory or in animal experiments. Furthermore, certain types of total implantable pump, such as the UJS-III axial pump and the UJS-IV aortic valvo-pump, have been developed. Only one type of TAH has been developed in China. The main constituents of this artificial heart are two axial pumps, two reservoir tanks mimicking the right and left atria, flow meters, two pressure gauges, and a resistance adaptor. Although the development of mechanical assist devices in China is still in a nascent stage, a number of different types of MCS devices are currently being studied.

  17. Process and device for the adsorptive separation of krypton from a krypton/nitrogen gas mixture

    International Nuclear Information System (INIS)

    Ringel, H.; Messler, M.

    1985-01-01

    The gas mixture flows through an adsorption column, which is filled with a means of adsorbing Krypton and nitrogen. The adsorption column is desorbed after adsorption of the gas components by a gaseous flushing material, which flows through the adsorption column in the same direction as the gas mixture. In order to achieve a high degree of separation, the adsorption material is loaded with nitrogen and Krypton from the gas inlet, where Krypton is only absorbed over part of the length of the whole column by the adsorption material. The part of the length is such that on desorption of the adsorption column with the flushing material at first only nitrogen and later only Krypton is obtained at the outlet of the adsorption column. (Waste gas system of a reprocession plant). (orig./HP) [de

  18. Numerically Simulated Impact of Gas Prandtl Number and Flow Model on Efficiency of the Machine-less Energetic Separation Device

    Directory of Open Access Journals (Sweden)

    K. S. Egorov

    2015-01-01

    Full Text Available The presented paper regards the influence of one of similarity criteria – the Prandtl number of gas (Pr - on the efficiency of the machine-less energetic separation device (Leontiev pipe, using numerical modeling in ANSYS software. This device, equally as Rank-Hilsch and Hartman-Schprenger pipes, is designed to separate one gas flow into two flows with different temperatures. One flow (supersonic streams out of the pipe with a temperature higher than initial and the other (subsonic flows out with a temperature lower than initial. This direction of energetic separation is true if the Prandtl number is less than 1 that corresponds to gases.The Prandtl number affects the efficiency of running Leontiev pipe indirectly both through a temperature difference on which a temperature recovery factor has an impact and through a thermal conductivity coefficient that shows the impact of heat transfer intensity between gas and solid wall.The Prandtl number range in the course of research was from 0.1 to 0.7. The Prandtl number value equal to 0.7 corresponds to the air or pure gases (for example, inert argon gas. The Prandtl number equal to 0.2 corresponds to the mixtures of inert gases such as helium-xenon.The numerical modeling completed for the supersonic flow with Mach number 2.0 shows that efficiency of the machine-less energetic separation device has been increased approximately 2 times with the Prandtl number decreasing from 0.7 to 0.2. Moreover, for the counter-flow scheme this effect is a little higher due to its larger heat efficiency in comparison with the straight-flow one.Also, the research shows that the main problem for the further increase of the Leontiev pipe efficiency is a small value of thermal conductivity coefficient, which requires an intensification of the heat exchange, especially in the supersonic flow. It can be obtained, for example, by using a system of oblique shock waves in the supersonic channel.

  19. Chromatographic Separation and Visual Detection on Wicking Microfluidic Devices: Quantitation of Cu2+ in Surface, Ground, and Drinking Water.

    Science.gov (United States)

    Bandara, Gayan C; Heist, Christopher A; Remcho, Vincent T

    2018-02-20

    Copper is widely applied in industrial and technological applications and is an essential micronutrient for humans and animals. However, exposure to high environmental levels of copper, especially through drinking water, can lead to copper toxicity, resulting in severe acute and chronic health effects. Therefore, regular monitoring of aqueous copper ions has become necessary as recent anthropogenic activities have led to elevated environmental concentrations of copper. On-site monitoring processes require an inexpensive, simple, and portable analytical approach capable of generating reliable qualitative and quantitative data efficiently. Membrane-based lateral flow microfluidic devices are ideal candidates as they facilitate rapid, inexpensive, and portable measurements. Here we present a simple, chromatographic separation approach in combination with a visual detection method for Cu 2+ quantitation, performed in a lateral flow microfluidic channel. This method appreciably minimizes interferences by incorporating a nonspecific polymer inclusion membrane (PIM) based assay with a "dot-counting" approach to quantification. In this study, hydrophobic polycaprolactone (PCL)-filled glass microfiber (GMF) membranes were used as the base substrate onto which the PIM was evenly dispensed as an array of dots. The devices thus prepared were then selectively exposed to oxygen radicals through a mask to generate a hydrophilic surface path along which the sample was wicked. Using this approach, copper concentrations from 1 to 20 ppm were quantified from 5 μL samples using only visual observation of the assay device.

  20. All-polymer bistable resistive memory device based on nanoscale phase-separated PCBM-ferroelectric blends

    KAUST Repository

    Khan, Yasser

    2012-11-21

    All polymer nonvolatile bistable memory devices are fabricated from blends of ferroelectric poly(vinylidenefluoride-trifluoroethylene (P(VDF-TrFE)) and n-type semiconducting [6,6]-phenyl-C61-butyric acid methyl ester (PCBM). The nanoscale phase separated films consist of PCBM domains that extend from bottom to top electrode, surrounded by a ferroelectric P(VDF-TrFE) matrix. Highly conducting poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) polymer electrodes are used to engineer band offsets at the interfaces. The devices display resistive switching behavior due to modulation of this injection barrier. With careful optimization of the solvent and processing conditions, it is possible to spin cast very smooth blend films (Rrms ≈ 7.94 nm) and with good reproducibility. The devices exhibit high Ion/I off ratios (≈3 × 103), low read voltages (≈5 V), excellent dielectric response at high frequencies (Ïμr ≈ 8.3 at 1 MHz), and excellent retention characteristics up to 10 000 s. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. DEVELOPMENT OF MESOPOROUS MEMBRANE MATERIALS FOR CO2 SEPARATION; SEMIANNUAL

    International Nuclear Information System (INIS)

    Wei-Heng Shih; Qiang Zhao; Tejas Patil

    2002-01-01

    The authors propose to use microporous silica as a suitable candidate for CO(sub 2)/N(sub 2) separation because the pore size is less than 10(angstrom). If a CO(sub 2)adsorbent is added to the microporous silica, the adsorption of CO(sub 2) can block the passage of N(sub 2) and an effective CO(sub 2)/N(sub 2) separator will be found. It was first demonstrated that microporous silica could be synthesized. The microporous silica was then impregnated with Ba(OH)(sub 2). The results of GC study showed that at temperatures between 50 C and 90 C, Ba-doped microporous silica can separate CO(sub 2) from N(sub 2) and the idea of a microporous membrane for CO(sub 2)/N(sub 2) separation is feasible. The new result gives strong support to the proposed research that was outlined in the Phase II proposal. They hope to be able to continue the research and build an effective CO(sub 2)/N(sub 2) membrane separator in the Phase II of this project

  2. Quality, Stability, and Safety Data of Packed Red Cells and Plasma Processed by Gravity Separation Using a New Fully Integrated Hollow-Fibre Filter Device

    Directory of Open Access Journals (Sweden)

    T. Brune

    2009-01-01

    Full Text Available Background. We developed a completely closed system based on gravity separation without centrifugation steps for separation of whole blood. With this new system we compared quality and stability of the processed blood components (PRC and plasma with respect to classical preparation. Furthermore the cost-effectiveness of this hollow fibre system was evaluated. Study Design and Methods. Whole blood collections of 15 regular blood donors were used for component preparation using the U shaped hollow fibre filter device. Results were compared to 15 whole blood preparations using centrifugation. The following parameters were evaluated: total hemoglobin, leukocyte counts, the serum concentration of total protein, lactate dehydrogenase (LDH and potassium. Furthermore ATIII, vWF and F VIII were analyzed at different timepoints. Results. packed red cells: the data directly after separation and after 42 days of storage are in line with the guidelines of the council of Europe. Plasma. all plasma quality data are in line with the guidelines of the council of Europe for quality assurance of plasma, except for a low protein amount (factor 0.75. Conclusion. Separation of whole blood on a clinical scale in this new closed system is feasible, however the plasma protein content must be optimized.

  3. Development and modification of glass membranes for aggressive gas separations

    Energy Technology Data Exchange (ETDEWEB)

    Lindbraaten, Arne

    2004-07-01

    Chlorine as a chemical is widespread in industry and found in a great variety of processes ranging from water purification to plastic production. In this thesis, a magnesium production factory was chosen as an example because it involved both chlorine - air separation and hydrogen -hydrogen chloride separation. Previously, various types of membrane materials have been tested out for their applicability in the chosen process. The materials previously tested either lacked sufficient membrane performance or sufficient membrane stability. As an attempt to improve both the membrane performance and stability, glass membranes are used in this thesis. Glass membranes are prepared from a borosilicate glass, via a phase separation followed by an acid leaching route. By choosing the appropriate phase separation temperature and acid to glass ratio, the membrane can be produced with an average pore diameter of 2 nm (or 4 nm). However, the 2 nm average pore size is still too large to separate gases with separation selectivities beyond the selectivities predicted from Knudsen diffusion theory. If the pores are narrowed, the selectivity may be raised while the flux hopefully is maintained. The narrowing of the pores was done by a silane coupling to the surface OH-groups on the glass. The silane coupling agent is of the dimethyl-acyl-chlorosilane type, where the length of the acyl chain varies from 1 carbon up to 18 carbons. Glass fibres are also tested in this work, which are produced without phase separation and their average pore size is smaller than the surface-modified glasses. To be able to compare the performance of the various membranes, performance measurements are performed and these measurements are evaluated by the separation power (product of the selectivity and the permeability of the fastest permeating compound). Because of the harsh chlorine or hydrogen chloride environment, to which the membranes are exposed in this work, the membrane stability is at least as

  4. Integrating the results of user research into medical device development: insights from a case study.

    Science.gov (United States)

    Martin, Jennifer L; Barnett, Julie

    2012-07-19

    It is well established that considering users is an important aspect of medical device development. However it is also well established that there are numerous barriers to successfully conducting user research and integrating the results into product development. It is not sufficient to simply conduct user research, it must also be effectively integrated into product development. A case study of the development of a new medical imaging device was conducted to examine in detail how users were involved in a medical device development project. Two user research studies were conducted: a requirements elicitation interview study and an early prototype evaluation using contextual inquiry. A descriptive in situ approach was taken to investigate how these studies contributed to the product development process and how the results of this work influenced the development of the technology. Data was collected qualitatively through interviews with the development team, participant observation at development meetings and document analysis. The focus was on investigating the barriers that exist to prevent user data from being integrated into product development. A number of individual, organisational and system barriers were identified that functioned to prevent the results of the user research being fully integrated into development. The user and technological aspects of development were seen as separate work streams during development. The expectations of the developers were that user research would collect requirements for the appearance of the device, rather than challenge its fundamental concept. The manner that the user data was communicated to the development team was not effective in conveying the significance or breadth of the findings. There are a range of informal and formal organisational processes that can affect the uptake of user data during medical device development. Adopting formal decision making processes may assist manufacturers to take a more integrated and

  5. Integrating the results of user research into medical device development: insights from a case study

    Directory of Open Access Journals (Sweden)

    Martin Jennifer L

    2012-07-01

    Full Text Available Abstract Background It is well established that considering users is an important aspect of medical device development. However it is also well established that there are numerous barriers to successfully conducting user research and integrating the results into product development. It is not sufficient to simply conduct user research, it must also be effectively integrated into product development. Methods A case study of the development of a new medical imaging device was conducted to examine in detail how users were involved in a medical device development project. Two user research studies were conducted: a requirements elicitation interview study and an early prototype evaluation using contextual inquiry. A descriptive in situ approach was taken to investigate how these studies contributed to the product development process and how the results of this work influenced the development of the technology. Data was collected qualitatively through interviews with the development team, participant observation at development meetings and document analysis. The focus was on investigating the barriers that exist to prevent user data from being integrated into product development. Results A number of individual, organisational and system barriers were identified that functioned to prevent the results of the user research being fully integrated into development. The user and technological aspects of development were seen as separate work streams during development. The expectations of the developers were that user research would collect requirements for the appearance of the device, rather than challenge its fundamental concept. The manner that the user data was communicated to the development team was not effective in conveying the significance or breadth of the findings. Conclusion There are a range of informal and formal organisational processes that can affect the uptake of user data during medical device development. Adopting formal decision

  6. Induction and separation of motion artifacts in EEG data using a mobile phantom head device.

    Science.gov (United States)

    Oliveira, Anderson S; Schlink, Bryan R; Hairston, W David; König, Peter; Ferris, Daniel P

    2016-06-01

    Electroencephalography (EEG) can assess brain activity during whole-body motion in humans but head motion can induce artifacts that obfuscate electrocortical signals. Definitive solutions for removing motion artifact from EEG have yet to be found, so creating methods to assess signal processing routines for removing motion artifact are needed. We present a novel method for investigating the influence of head motion on EEG recordings as well as for assessing the efficacy of signal processing approaches intended to remove motion artifact. We used a phantom head device to mimic electrical properties of the human head with three controlled dipolar sources of electrical activity embedded in the phantom. We induced sinusoidal vertical motions on the phantom head using a custom-built platform and recorded EEG signals with three different acquisition systems while the head was both stationary and in varied motion conditions. Recordings showed up to 80% reductions in signal-to-noise ratio (SNR) and up to 3600% increases in the power spectrum as a function of motion amplitude and frequency. Independent component analysis (ICA) successfully isolated the three dipolar sources across all conditions and systems. There was a high correlation (r > 0.85) and marginal increase in the independent components' (ICs) power spectrum (∼15%) when comparing stationary and motion parameters. The SNR of the IC activation was 400%-700% higher in comparison to the channel data SNR, attenuating the effects of motion on SNR. Our results suggest that the phantom head and motion platform can be used to assess motion artifact removal algorithms and compare different EEG systems for motion artifact sensitivity. In addition, ICA is effective in isolating target electrocortical events and marginally improving SNR in relation to stationary recordings.

  7. Novel Biomedical Device Utilizing Light-Emitting Nanostructures Developed

    Science.gov (United States)

    Scardelletti, Maximilian C.; Goldman, Rachel

    2004-01-01

    Sketches and chemical diagrams of state-of-the-art device and novel proposed device are presented. Current device uses a diode laser that emits into a fluorescent fluid only one wavelength and a photodetector diode that detects only one wavelength. Only one type of bacteria can be detected. The proposed device uses a quantum dot array that emits into a fluorescent fluid multiple wavelengths and an NIR 512 spectrometer that scans 0.8- to 1.7-mm wavelengths. Hundreds of different bacteria and viruses can be detected. A novel biomedical device is being developed at the NASA Glenn Research Center in cooperation with the University of Michigan. This device uses nano-structured quantum dots that emit light in the near-infrared (IR) region. The nanostructured quantum dots are used as a source and excite fluorochrome polymers coupled with antibodies that seek out and attach to specific bacteria and viruses. The fluorochrome polymers/antibodies fluoresce at specific wavelengths in the near-IR spectrum, but these wavelengths are offset from the excitation wavelength and can be detected with a tunable spectrometer. The device will be used to detect the presence of viruses and bacteria in simple fluids and eventually in more complex fluids, such as blood. Current state-of-the-art devices are limited to single bacteria or virus detection and a considerable amount of time and effort is required to prepare samples for analysis. Most importantly, the devices are quite large and cumbersome, which prohibits them from being used on the International Space Station and the space shuttles. This novel device uses nanostructured quantum dots which, through molecular beam epitaxy and highly selective annealing processes, can be developed into an illumination source that could potentially generate hundreds of specific wavelengths. As a result, this device will be able to excite hundreds of antibody/fluorochrome polymer combinations, which in turn could be used to detect hundreds of bacteria

  8. Development of Halide and Oxy-Halides for Isotopic Separations

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Leigh R. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Johnson, Aaron T. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Pfeiffer, Jana [Idaho National Lab. (INL), Idaho Falls, ID (United States); Finck, Martha R. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-10-01

    The goal of this project was to synthesize a volatile form of Np for introduction into mass spectrometers at INL. Volatile solids of the 5f elements are typically those of the halides (e.g. UF6), however fluorine is highly corrosive to the sensitive internal components of the mass separator, and the other volatile halides exist as several different stable isotopes in nature. However, iodide is both mono-isotopic and volatile, and as such presents an avenue for creation of a form of Np suitable for introduction into the mass separator. To accomplish this goal, the technical work in the project sought to establish a novel synthetic route for the conversion NpO2+ (dissolved in nitric acid) to NpI3 and NpI4.

  9. Development laser light facility for uranium isotope separation

    International Nuclear Information System (INIS)

    Dickinson, G.J.

    1992-01-01

    A laser light facility has been built and successfully commissioned as part of a programme to explore the economic potential of Laser Isotope Separation of Uranium. The laser systems are comprised of tunable dye lasers pumped by copper vapour lasers. The requirements for optical beam stability, alignment of lasers in chains, and protection of optical coatings have made challenging demands on the engineering design and operation of the facility. (Author)

  10. Developing medical device software in compliance with regulations.

    Science.gov (United States)

    Zema, M; Rosati, S; Gioia, V; Knaflitz, M; Balestra, G

    2015-08-01

    In the last decade, the use of information technology (IT) in healthcare has taken a growing role. In fact, the adoption of an increasing number of computer tools has led to several benefits related to the process of patient care and allowed easier access to social and health care resources. At the same time this trend gave rise to new challenges related to the implementation of these new technologies. Software used in healthcare can be classified as medical devices depending on the way they are used and on their functional characteristics. If they are classified as medical devices they must satisfy specific regulations. The aim of this work is to present a software development framework that can allow the production of safe and high quality medical device software and to highlight the correspondence between each software development phase and the appropriate standard and/or regulation.

  11. Main principles of developing exploitation models of semiconductor devices

    Science.gov (United States)

    Gradoboev, A. V.; Simonova, A. V.

    2018-05-01

    The paper represents primary tasks, solutions of which allow to develop the exploitation modes of semiconductor devices taking into account complex and combined influence of ionizing irradiation and operation factors. The structure of the exploitation model of the semiconductor device is presented, which is based on radiation and reliability models. Furthermore, it was shown that the exploitation model should take into account complex and combine influence of various ionizing irradiation types and operation factors. The algorithm of developing the exploitation model of the semiconductor devices is proposed. The possibility of creating the radiation model of Schottky barrier diode, Schottky field-effect transistor and Gunn diode is shown based on the available experimental data. The basic exploitation model of IR-LEDs based upon double AlGaAs heterostructures is represented. The practical application of the exploitation models will allow to output the electronic products with guaranteed operational properties.

  12. The Complexities of Developing Accessible Web Content for Mobile Devices

    Science.gov (United States)

    Hancock, Richard

    This paper is concerned with the development of accessible mobile content and the complexities that arise during this process. The paper gives an overview of the popularity and advantages of mobile devices before tackling the issues surrounding content development, particularly within an educational context. The paper concludes with an overview of an application that was developed for higher education students within a UK college that had a mobile counterpart, allowing the artefact to transcend the typical desktop environment.

  13. Rapid development of paper-based fluidic diagnostic devices

    CSIR Research Space (South Africa)

    Smith, S

    2014-11-01

    Full Text Available We present a method for rapid and low-cost development of microfluidic diagnostic devices using paper-based techniques. Specifically, the implementation of fluidic flow paths and electronics on paper are demonstrated, with the goal of producing...

  14. Development and Manufacture of Polymer-based Electrochromic Devices

    DEFF Research Database (Denmark)

    Jensen, Jacob; Hösel, Markus; Dyer, Aubrey L.

    2015-01-01

    -to-roll methods compatible with upscaling and manufacture. The successful approaches to operational devices are presented in detail, as well as areas where future research would have a high impact and accelerate the development such as highly conducting and transparent substrates, electrolytes adapted...

  15. Development of new microporous silica membranes for gas separation

    International Nuclear Information System (INIS)

    Camelia Barboiu; Alejandro Mourgues; Beatrice Sala; Serge de Perthuis; Camelia Barboiu; Alejandro Mourgues; Beatrice Sala; Anne Julbe; Jose Sanchez

    2006-01-01

    This paper presents the synthesis and the application of molecular sieving ceramic membranes to purify hydrogen or helium from various gas mixtures. The membranes prepared in this work consist of an ultra-microporous silica-based separative layer produced via a sol-gel process. Ultra microporous silica containing boron is synthesized by the acid catalyzed hydrolysis and condensation of tetra-ethyl-ortho-silicate in ethanol. The layer is deposited inside a tubular asymmetric alumina support with a meso-porous y alumina inner layer. The thickness of the silica layers after treatment is about 200 nm, estimated from their cross-section SEM micrographs. Ultra-microporous membranes (with pore sizes less than 0.7 nm) are thus required to get high selectivity. Such membranes enable to carry out gas separation up to 500 deg C under a transmembrane pressure lower than 8 bars. He and H 2 permeance values close to 10 -7 mol.m -2 s -1 Pa -1 are obtained, associated with ideal selectivities α(He/CO 2 ) and α(H 2 /CO 2 ) between 10 and 20 at 300 deg C. (authors)

  16. Development of cutting device for irradiated fuel rod

    International Nuclear Information System (INIS)

    Lee, E. P.; Jun, Y. B.; Hong, K. P.; Min, D. K.; Lee, H. K.; Su, H. S.; Kim, K. S.; Kwon, H. M.; Joo, Y. S.; Yoo, K. S.; Joo, J. S.; Kim, E. K.

    2004-01-01

    Post Irradiation Examination(PIE) on irradiated fuel rods is essential for the evaluation of integrity and irradiation performance of fuel rods of commercial reactor fuel. For PIE, fuel rods should be cut very precisely. The cutting positions selected from NDT data are very important for further destructive examination and analysis. A fuel rod cutting device was developed witch can cut fuel rods longitudinal very precisely and can also cut the fuels into the same length rod cuts repeatedly. It is also easy to remove the fuel cutting powder after cutting works and it can extend the life time of cutting device and lower the contamination level of hot cell

  17. Development of beam diagnostic devices for characterizing electron guns

    International Nuclear Information System (INIS)

    Bhattacharjee, D.; Tiwari, R.; Jayaprakash, D.; Mishra, R.L.; Sarukte, H.; Waghmare, A.; Thakur, N.; Dixit, K.P.

    2015-01-01

    The electron guns for the DC accelerators and RF Linacs are designed and developed at EBC/APPD/BARC, Kharghar. These electron guns need to be characterized for its design and performance. Two test benches were developed for characterizing the electron guns. Various beam diagnostic devices for measuring beam currents and beam sizes were developed. Conical faraday cup, segmented faraday cup, slit scanning bellows movement arrangement, multi-plate beam size measurement setup, multi- wire beam size measurement setup, Aluminum foil puncture assembly etc. were developed and used. The paper presents the in-house development of various beam diagnostics for characterizing electron guns and their use. (author)

  18. Development of an Erlang System Adaopted to Embedded Devices

    OpenAIRE

    Andersson, Fredrik; Bergström, Fabian

    2011-01-01

    Erlang is a powerful and robust language for writing massively parallel and distributed applications. With the introduction of multi-core ARM processors, the embedded market will be looking for ways of taking advantage of the newfound opportunities for parallelism. To support the development of embedded applications using Erlang we want to provide Erlang and Embedded developers with a run-time system suited for embedded devices. We have managed to shrink the disk size of the Erlang runtime sy...

  19. Development of signal acquisition device of rotating coil measurement system

    International Nuclear Information System (INIS)

    Zhou Jianxin; Li Li; Kang Wen; Deng Chengdong; Yin Baogui; Fu Shinian

    2013-01-01

    A new rotating coil magnetic measurement system using the technical solution of the combination of a dynamic signal acquisition card and software with specific functions was developed. The acquisition device of the system successfully implemented the function of the PDI-5025 integrator. The sampling rate, the range, the accuracy and the flexibility of the system were improved. The development program of signal acquisition equipment, the realization of the acquisition function and the reliability and stability of the system were introduced. (authors)

  20. Developing an Assessment (Tool) for Touch Screen Devices.

    Science.gov (United States)

    Danial-Saad, Alexandra; Chiari, Lorenzo

    2017-01-01

    Touch screen devices have become prevalent in our lives. Assistive technology experts working with people with disabilities face difficulty in understanding and assessing the problems experienced by individuals with disabilities in operating touch screen devices. This paper presents the processes of collecting and creating the required knowledge needed for assessing the user's skills for operating various touch screen devices, in order to develop an application for assessing the user's abilities and limitations. A six step procedure was used to collect and validate the required knowledge for the assessment from a multidisciplinary team. To determine the agreement levels between the experts, content validity was calculated. To test correlation between the experts from the different disciplines, a comparison was made between the discipline groups and their choice of specific skills/measurements. The final number of domains and skills/measurements was 15 domains and 50 skills/measurements. The result of Cronbach's α test for the final assessment questionnaire (50 skills/measurements) was 0.94, which indicates a high degree of reliability. The results of Kruskal-Wallis test showed the lack of any significant difference between agreements of the clinicians and the technicians groups, but significant differences were found between the educators and the clinicians groups. Each of the skills appearing in the final questionnaire was illustrated in a flowchart in preparation for developing the assessment (tool) for using touch screen devices.

  1. Development of an irradiation device for electron beam wastewater treatment

    International Nuclear Information System (INIS)

    Rela, Paulo Roberto

    2003-01-01

    When domestic or industrial effluents with synthetic compounds are disposed without an adequate treatment, they impact negatively the environment with damages to aquatic life and for the human being. Both population and use of goods and services that contribute for the hazardous waste are growing. Hazardous regulations are becoming more restrictive and technologies, which do not destroy these products, are becoming less acceptable. The electron beam radiation process is an advanced oxidation process, that produces highly reactive radicals resulting in mineralization of the contaminant. In this work was developed an irradiation system in order to optimize the interaction of electron beam delivered from the accelerator with the processed effluent. It is composed by an irradiation device where the effluent presents to the electron beam in an up flow stream and a process control unit that uses the calorimetric principle. The developed irradiation device has a different configuration from the devices used by others researchers that are working with this technology. It was studied the technical and economic feasibility, comparing with the literature the results of the irradiation device demonstrated that it has a superior performance, becoming an process for use in disinfection and degradation of hazardous organic compounds of wastewater from domestic and industrial origin, contributing as an alternative technology for Sanitary Engineering. (author)

  2. Development of Magnetorheological Resistive Exercise Device for Rowing Machine

    Directory of Open Access Journals (Sweden)

    Vytautas Grigas

    2016-01-01

    Full Text Available Training equipment used by professional sportsmen has a great impact on their sport performance. Most universal exercisers may help only to improve the general physical condition due to the specific kinematics and peculiar resistance generated by their loading units. Training of effective techniques and learning of psychomotor skills are possible only when exercisers conform to the movements and resistance typical for particular sports kinematically and dynamically. Methodology of developing a magnetorheological resistive exercise device for generating the desired law of passive resistance force and its application in a lever-type rowing machine are described in the paper. The structural parameters of a controllable hydraulic cylinder type device were found by means of the computational fluid dynamics simulation performed by ANSYS CFX software. Parameters describing the magnetorheological fluid as non-Newtonian were determined by combining numerical and experimental research of the resistance force generated by the original magnetorheological damper. A structural scheme of the device control system was developed and the variation of the strength of magnetic field that affects the magnetorheological fluid circulating in the device was determined, ensuring a variation of the resistance force on the oar handle adequate for the resistance that occurs during a real boat rowing stroke.

  3. The Development of 1Balance: A Connected Medical Device for Measuring Human Balance

    Directory of Open Access Journals (Sweden)

    Heikki Sjöman

    2018-05-01

    Full Text Available Prototyping (iterative loops of design–build–test is a proven method of efficiently developing new products. Developing products not only quickly, but that are also fit for purpose, implies engaging the end users and iterating the technology at hand. However, there is currently little research on how engineering design can approach developing connected devices. The purpose of this paper is to distinguish and discuss design approaches that are suitable for connected devices. Internet of Things devices consist of both the physical products themselves and the data that is coming out of the products, which we define as the external and internal data, respectively. They both can be prototyped separately, but since the data acquired can influence the design of the device and vice versa, we propose to link these two together in the product development process. This issue becomes more apparent when designing networks of sensors, e.g., for complex artificial intelligence (AI databases. We explain the principle by describing the development of 1Balance through six different prototypes for human balance measurement. Technologically quantifying balance is an underused approach for objectively evaluating the state of a human’s performance. The authors have developed a mobile application for monitoring balance as a physiological signal (amount of sway via a compact wireless inertial measurement unit (IMU sensor strapped to the body of the subject for the duration of the measurement. We describe the design process for developing this connected medical device, as well as how the acquired data was used to improve the design of the product. In conclusion, we propose conceptually connecting the external and internal data prototyping loops.

  4. Controller Development for a Separate Meter-In Separate Meter-Out Fluid Power Valve for Mobile Applications

    DEFF Research Database (Denmark)

    Nielsen, Brian

    machinery. For a rotary motion electrical motors controlled by using power electronics is a competing technology because of their high energy efficiency. Additionally, the energy density of electrical devices is still increasing. In fluid power systems where more consumers (cylinders or motors) are supplied...... relative stability due to design restrictions. Robust controllers for the valve using the remaining pilot control method are developed. The robustness is evaluated by simulations and afterwards the controllers are tested experimentally. A model of a hydraulic actuator system with a flexible load structure...

  5. A model of user engagement in medical device development.

    Science.gov (United States)

    Grocott, Patricia; Weir, Heather; Ram, Mala Bridgelal

    2007-01-01

    The purpose of this paper is to address three topical themes: user involvement in health services research; determining the value of new medical technologies in patient care pathways, furthering knowledge related to quality in health and social care; and knowledge exchange between manufacturers, health service supply chain networks and device users. The model is being validated in a case study in progress. The latter is a "proving ground" study for a translational research company. Medical devices play a pivotal role in the management of chronic diseases, across all care settings. Failure to engage users in device development inevitably affects the quality of clinical outcomes. A model of user engagement is presented, turning unmet needs for medical devices into viable commercial propositions. A case study investigating the perceptions of individuals with Epidermolysis Bullosa (EB), their lay and professional carers into unmet needs. EB is an inherited condition affecting the skin and mucosal linings that leads to blistering and wounds. Qualitative data are being collected to generate understanding of unmet needs and wound care products. These needs are being translated into new design concepts and prototypes. Prototypes will be evaluated in an n = 1 experimental design, generating quantitative outcomes data. There are generalisations from the case study, and the model outlined. New products for managing EB wounds can logically benefit other groups. The model is transferable to other clinical problems, which can benefit from research and technological advances that are integral to clinical needs and care.

  6. Development of a human body RMN imaging device

    International Nuclear Information System (INIS)

    Saint-Jalmes, H.

    1984-03-01

    Imaging device for human body is studied in this thesis. The section images presented are got by a projection-reconstruction method associated to a section plane selection by an oscillating gradient application. Different stages of the machine development are presented: - design and calculation of a resistive magnet for very homogeneous field imaging - design of gradient coils for imaging magnets - realization of control and acquisition interfaces - realization of imaging software in real time [fr

  7. Development of Nanoscale Graphitic Devices and The Transport Characterization

    International Nuclear Information System (INIS)

    Gunasekaran, Venugopal

    2011-02-01

    This dissertation describes the development of graphitic based nanoscale devices with its fabrication and transport characterization results. It covers graphite nano-scale stacked-junctions fabricated using focused ion beam (FIB) 3-D etching technique, a single layer graphite layer (graphene) preparation and its electrical transport characterization results and the synthesis and investigation of electrical transport behavior of graphene oxide based thin film devices. The first chapter describes the basic information about the carbon family in detail in which the electronic properties and structure of graphite, graphene and graphene oxide are discussed. In addition, the necessity of developing nanoscale graphitic devices is given. The second chapter explains the experimental techniques used in this research for fabricating nanoscale devices which includes focused ion beam 3-D fabrication procedures, mechanical exfoliation technique and photolithographic methods. In third chapter, we have reported the results on temperature dependence of graphite planar-type structures fabricated along ab-plane. In the fourth and fifth chapters, the fabrication and electrical transport characteristics of large in-plane area graphite planar-type structures (fabricated along ab-plane and c-axis) were discussed and their transport anisotropy properties were investigated briefly. In the sixth chapter, we focused the fabrication of the submicron sized graphite stacked junctions and their electrical transport characterization studies. In which, FIB was used to fabricated the submicron junctions with various in-plane area (with same stack height) are and their transport characteristics were compared. The seventh chapter reports investigation of electrical transport results of nanoscale graphite stacked-junctions in which the temperature dependent transport (R-T) studies, current-voltage measurements for the various in-plane areas and for various stack height samples were analyzed. The

  8. Development of a micro total analytic system based on isotachophoresis for the separation and characterization of lanthanides

    International Nuclear Information System (INIS)

    Vio, L.

    2010-01-01

    The accurate and reproducible characterization of radioactive solutions in isotope composition and concentration is an essential topic for analytical laboratories in the nuclear field. In order to reduce manipulation time in glove box and production of contaminated wastes, it is necessary to propose innovative and efficient solutions for these analyses. Since few years, microchips are a major field of development in analytical chemistry and those devices could provide a solution which fits the needs of nuclear industry. The aim of this work is to design a disposable analytical micro-device devoted to lanthanide separation from spent nuclear fuel before their analysis in mass spectrometry. Designed to be used in place of a separation process by liquid chromatography which is involved in a three step protocol, the new protocol based on isotachophoresis (ITP) keeps compatible with the other two steps. The complete separation of lanthanides by ITP was obtained by the use of only one chelating compound rigorously selected: the 2-hydroxy 2-methyl butyric acid (HMBA). The main parameters involved in solute resolution were defined from the theoretical models of ITP and experimental studies of the influence of these parameters allowed to optimize the geometry of the system and to improve its performances. To suppress cleaning of the system and, consequently, to strongly reduce both liquid waste volume and handling radioactive material, the ITP protocol was transferred in a polymeric (COC) disposable microchip especially developed for this purpose. (author) [fr

  9. Develop of omni-tritium sample preparation device

    International Nuclear Information System (INIS)

    Tian Junhua; Zheng Min; Zhang Dong

    2008-06-01

    The content of total tritium analysis is required in order to know the tritium contaminated degree of biological samples accurately. But the conversion and collection of organic tritium are difficult. A device to treat total tritium samples was developed. Plant samples were treated by combustion and catalysis. After expelling the free HTO in the samples when heated in abundant oxygen, the samples were ignited. Combustion gas passed the catalysts at 800 degree C and its oxidation was catalyzed, and then the combined tritium in tissues was converted into HTO. HTO was collected by water-cooling tube and condenser. For other samples, HTO was treated and collected by high temperature (The highest temperature is 1000 degree C)-catalysis-double condensation method. This device had solved the problem that organic tritium is difficult to gather. (authors)

  10. Developing E-learning Courses for Mobile Devices

    Directory of Open Access Journals (Sweden)

    R. Szabados

    2007-01-01

    Full Text Available The recent and rapid development of mobile devices and the increasing popularity of e learning have created a demand for mobile learning packages and environments. We have analyzed the possibilities of adapting the existing content for mobile devices, and have implemented two fundamentally different systems to satisfy the demand that has arisen. One of the systems creates e learning courses from existing materials and adapts them to the specified platform (this system realizes the functionalities of the Content Management System. The other system is a modified version of the Moodle Learning Management System, which can adapt existing courses right before displaying them. This paper discuses the fundamentals of e learning, the design considerations and investigates various methods of scalable video coding. Finally the realization details of the two systems are presented. 

  11. Optoelectronic stereoscopic device for diagnostics, treatment, and developing of binocular vision

    Science.gov (United States)

    Pautova, Larisa; Elkhov, Victor A.; Ovechkis, Yuri N.

    2003-08-01

    Operation of the device is based on alternative generation of pictures for left and right eyes on the monitor screen. Controller gives pulses on LCG so that shutter for left or right eye opens synchronously with pictures. The device provides frequency of switching more than 100 Hz, and that is why the flickering is absent. Thus, a separate demonstration of images to the left eye or to the right one in turn is obtained for patients being unaware and creates the conditions of binocular perception clsoe to natural ones without any additional separation of vision fields. LC-cell transfer characteristic coodination with time parameters of monitor screen has enabled to improve stereo image quality. Complicated problem of computer stereo images with LC-glasses is so called 'ghosts' - noise images that come to blocked eye. We reduced its influence by adapting stereo images to phosphor and LC-cells characteristics. The device is intended for diagnostics and treatment of stabismus, amblyopia and other binocular and stereoscopic vision impairments, for cultivating, training and developing of stereoscopic vision, for measurements of horizontal and vertical phoria, phusion reserves, the stereovision acuity and some else, for fixing central scotoma borders, as well as suppression scotoma in strabismus too.

  12. From Recombination Dynamics to Device Performance: Quantifying the Efficiency of Exciton Dissociation, Charge Separation, and Extraction in Bulk Heterojunction Solar Cells with Fluorine-Substituted Polymer Donors

    KAUST Repository

    Gorenflot, Julien

    2017-09-28

    An original set of experimental and modeling tools is used to quantify the yield of each of the physical processes leading to photocurrent generation in organic bulk heterojunction solar cells, enabling evaluation of materials and processing condition beyond the trivial comparison of device performances. Transient absorption spectroscopy, “the” technique to monitor all intermediate states over the entire relevant timescale, is combined with time-delayed collection field experiments, transfer matrix simulations, spectral deconvolution, and parametrization of the charge carrier recombination by a two-pool model, allowing quantification of densities of excitons and charges and extrapolation of their kinetics to device-relevant conditions. Photon absorption, charge transfer, charge separation, and charge extraction are all quantified for two recently developed wide-bandgap donor polymers: poly(4,8-bis((2-ethylhexyl)oxy)benzo[1,2-b:4,5-b′]dithiophene-3,4-difluorothiophene) (PBDT[2F]T) and its nonfluorinated counterpart poly(4,8-bis((2-ethylhexyl)oxy)benzo[1,2-b:4,5-b′]dithiophene-3,4-thiophene) (PBDT[2H]T) combined with PC71BM in bulk heterojunctions. The product of these yields is shown to agree well with the devices\\' external quantum efficiency. This methodology elucidates in the specific case studied here the origin of improved photocurrents obtained when using PBDT[2F]T instead of PBDT[2H]T as well as upon using solvent additives. Furthermore, a higher charge transfer (CT)-state energy is shown to lead to significantly lower energy losses (resulting in higher VOC) during charge generation compared to P3HT:PCBM.

  13. From Recombination Dynamics to Device Performance: Quantifying the Efficiency of Exciton Dissociation, Charge Separation, and Extraction in Bulk Heterojunction Solar Cells with Fluorine-Substituted Polymer Donors

    KAUST Repository

    Gorenflot, Julien; Paulke, Andreas; Piersimoni, Fortunato; Wolf, Jannic Sebastian; Kan, Zhipeng; Cruciani, Federico; El Labban, Abdulrahman; Neher, Dieter; Beaujuge, Pierre; Laquai, Fré dé ric

    2017-01-01

    An original set of experimental and modeling tools is used to quantify the yield of each of the physical processes leading to photocurrent generation in organic bulk heterojunction solar cells, enabling evaluation of materials and processing condition beyond the trivial comparison of device performances. Transient absorption spectroscopy, “the” technique to monitor all intermediate states over the entire relevant timescale, is combined with time-delayed collection field experiments, transfer matrix simulations, spectral deconvolution, and parametrization of the charge carrier recombination by a two-pool model, allowing quantification of densities of excitons and charges and extrapolation of their kinetics to device-relevant conditions. Photon absorption, charge transfer, charge separation, and charge extraction are all quantified for two recently developed wide-bandgap donor polymers: poly(4,8-bis((2-ethylhexyl)oxy)benzo[1,2-b:4,5-b′]dithiophene-3,4-difluorothiophene) (PBDT[2F]T) and its nonfluorinated counterpart poly(4,8-bis((2-ethylhexyl)oxy)benzo[1,2-b:4,5-b′]dithiophene-3,4-thiophene) (PBDT[2H]T) combined with PC71BM in bulk heterojunctions. The product of these yields is shown to agree well with the devices' external quantum efficiency. This methodology elucidates in the specific case studied here the origin of improved photocurrents obtained when using PBDT[2F]T instead of PBDT[2H]T as well as upon using solvent additives. Furthermore, a higher charge transfer (CT)-state energy is shown to lead to significantly lower energy losses (resulting in higher VOC) during charge generation compared to P3HT:PCBM.

  14. Multi-interface Level Sensors and New Development in Monitoring and Control of Oil Separators

    Directory of Open Access Journals (Sweden)

    Wuqiang Yang

    2006-04-01

    Full Text Available In the oil industry, huge saving may be made if suitable multi-interface levelmeasurement systems are employed for effectively monitoring crude oil separators andefficient control of their operation. A number of techniques, e.g. externally mounteddisplacers, differential pressure transmitters and capacitance rod devices, have beendeveloped to measure the separation process with gas, oil, water and other components.Because of the unavailability of suitable multi-interface level measurement systems, oilseparators are currently operated by the trial-and-error approach. In this paper someconventional techniques, which have been used for level measurement in industry, and newdevelopment are discussed.

  15. Devices development and techniques research for space life sciences

    Science.gov (United States)

    Zhang, A.; Liu, B.; Zheng, C.

    The development process and the status quo of the devices and techniques for space life science in China and the main research results in this field achieved by Shanghai Institute of Technical Physics SITP CAS are reviewed concisely in this paper On the base of analyzing the requirements of devices and techniques for supporting space life science experiments and researches one designment idea of developing different intelligent modules with professional function standard interface and easy to be integrated into system is put forward and the realization method of the experiment system with intelligent distributed control based on the field bus are discussed in three hierarchies Typical sensing or control function cells with certain self-determination control data management and communication abilities are designed and developed which are called Intelligent Agents Digital hardware network system which are consisted of the distributed Agents as the intelligent node is constructed with the normative opening field bus technology The multitask and real-time control application softwares are developed in the embedded RTOS circumstance which is implanted into the system hardware and space life science experiment system platform with characteristic of multitasks multi-courses professional and instant integration will be constructed

  16. Device development for radioecology monitoring in Azerbaijan Republic

    International Nuclear Information System (INIS)

    Bayramov, Z.T.

    2002-01-01

    Last time in the territory of Azerbaijan Republic that's in the land and especially in Azerbaijan sector of Caspian Sea have observed the irreversible processes as result of anthropogenic influences to the environment. In the main these inclinations envelope following from signed oil contracts the boring works for prospecting and production, building works on the oil pipelines and increase of quantity of the wastes created by these kinds of an activity. But at the land these inclinations envelope the revealing of radioactive materials at not controlled sectors of military bases leave in inheritance by former Soviet Union. At the same time have observed sharp increase of the transit load transporting power on the 'Silk way' route restored within the frames of TRACEKA. And that, in its turn, demand the organization of corresponding control of these loads. For organization of above-mentioned works have proposed next devices and equipment: The device DRG-01Az designed for an exposure dose power measurements of gamma radiations. Air gamma spectrometer. Managed from scientific-research craft the gamma spectrometer for gamma removals of seabed. Stationary radiation post for continuous control of the transit trucks. Proposed devices have worked out by the group of Special Space Device Development Bureau of Azerbaijan National Aerospace Agency. It should be noted that this group had important achievements at the sphere of space device development still since 70-th years. So in 1981 within the frames of the Soviet-French combined experiment was make a multi-channel gamma spectrometer mounted on the aerostat flied on the large heights (30-40 km). In 1983 was work out an orbital device 'RS-17' located at the satellite 'Cosmos-1638'. In 1987 was make a gamma telescope 'Pulsar X-1' established on the orbital station 'Mir'. A telescope is working successfully till now. Above-mentioned devices establish on the basis of obtained achievements. For example, the constructional demands

  17. Counterfeit drugs and medical devices in developing countries

    Directory of Open Access Journals (Sweden)

    Glass BD

    2014-03-01

    Full Text Available Beverley D GlassSchool of Pharmacy and Molecular Sciences, James Cook University, Townsville, QLD, AustraliaAbstract: The World Health Organization has reported that counterfeit medicines potentially make up more than 50% of the global drug market, with a significant proportion of these fake products being encountered in developing countries. This occurrence is attributed to a lack of effective regulation and a weak enforcement capacity existing in these countries, with an increase in this trade resulting from the growing size and sophistication of drug counterfeiters. In addition, due to both cost and lack of availability of medicines, consumers in developing countries are more likely to seek out these inexpensive options. The World Health Organization is mindful of the impact of counterfeit drugs on consumer confidence in health care systems, health professionals, the supply chain, and genuine suppliers of medicines and medical devices. Antibiotics, antituberculosis drugs, and antimalarial and antiretroviral drugs are frequently targeted, with reports of 60% of the anti-infective drugs in Asia and Africa containing active pharmaceutical ingredients outside their pharmacopoeial limits. This has obvious public health implications of increasing drug resistance and negating all the efforts that have already gone into the provision of medicines to treat these life threatening conditions in the developing world. This review, while focusing on counterfeit medicines and medical devices in developing countries, will present information on their impact and how these issues can be addressed by regulation and control of the supply chain using technology appropriate to the developing world. The complexity of the problem will also be highlighted in terms of the definition of counterfeit and substandard medicines, including gray pharmaceuticals. Although this issue presents as a global public health problem, outcomes in developing countries where counterfeit

  18. Development of quantum device simulator NEMO-VN1

    Science.gov (United States)

    Hien, Dinh Sy; Thi Luong, Nguyen; Hoang Minh, Le; Tien Phuc, Tran; Thanh Trung, Pham; Dong, Bui An; Thu Thao, Huynh Lam; Van Le Thanh, Nguyen; Tuan, Thi Tran Anh; Hoang Trung, Huynh; Thi Thanh Nhan, Nguyen; Viet Nga, Dinh

    2009-09-01

    We have developed NEMO-VN1 (NanoElectronic MOdelling), a new modelling tool that simulates a wide variety of quantum devices including Quantum Dot (QD), Resonant Tunneling Diode (RTD), Resonant Tunneling Transistor (RTT), Single Electron Transistor (SET), Molecular FET (MFET), Carbon Nanotube FET (CNTFET), Spin FET (SPINFET). It has a collection of models that allow user to trade off between calculation speed and accuracy. NEMO-VN1 also includes a graphic user interface of Matlab that enables parameter entry, calculation control, intuitive display of calculation results, and in-situ data analysis methods.

  19. Development of quantum device simulator NEMO-VN1

    International Nuclear Information System (INIS)

    Dinh Sy Hien; Nguyen Thi Luong; Le Hoang Minh; Tran Tien Phuc; Pham Thanh Trung; Bui An Dong; Huynh Lam Thu Thao; Nguyen Van Le Thanh; Thi Tran Anh Tuan; Huynh Hoang Trung; Nguyen Thi Thanh Nhan; Dinh Viet Nga

    2009-01-01

    We have developed NEMO-VN1 (NanoElectronic MOdelling), a new modelling tool that simulates a wide variety of quantum devices including Quantum Dot (QD), Resonant Tunneling Diode (RTD), Resonant Tunneling Transistor (RTT), Single Electron Transistor (SET), Molecular FET (MFET), Carbon Nanotube FET (CNTFET), Spin FET (SPINFET). It has a collection of models that allow user to trade off between calculation speed and accuracy. NEMO-VN1 also includes a graphic user interface of Matlab that enables parameter entry, calculation control, intuitive display of calculation results, and in-situ data analysis methods.

  20. Development trends for insertion devices of future synchrotron light sources

    Directory of Open Access Journals (Sweden)

    C. S. Hwang

    2011-04-01

    Full Text Available The in-vacuum undulator with a permanent magnet at room temperature is a mature technology and is widely used; with a short period length in a medium-energy facility, it can enhance photon brilliance in the hard x-ray region. A cryogenic permanent magnet has been investigated as an in-vacuum undulator; this undulator will become the best prospective device to satisfy the requirements of a photon source with great brilliance in the hard x-ray region. For the further hard x-ray region, a superconducting wiggler can provide great flux with a continuous spectrum, whereas a superconducting undulator will provide great brilliance with a discrete spectrum. High-temperature superconducting wires are highly promising for use in the development of superconducting undulators; unique algorithms for their development with an extremely short period in a small-magnet gap have been devised. Some out-of-vacuum planar undulators with special functions must also be fabricated to enable diverse applications in various light-source facilities. This article describes current and future developments for insertion devices in storage-ring and free-electron-laser facilities and discusses their feasibility for use therein.

  1. Recent developments in the extraction separation method for treatment of high-level liquid waste

    International Nuclear Information System (INIS)

    Jiao Rongzhou; Song Chongli; Zhu Yongjun

    2000-01-01

    A description and review of the recent developments in the extraction separation method for partitioning transuranium elements from high-level liquid waste (HLLW) is presented. The extraction separation processes such as TRUEX process, DIAMEX process, DIDPA process, CTH process, TRPO process are briefly discussed

  2. Connectedness and Separation in Parent-Adolescent Relationships: Indicators of a Successful Identity Development?

    Science.gov (United States)

    Masche, J. Gowert; Barber, Brian K.

    On the basis of individuation approaches to the study of parent-adolescent relationships, this study hypothesized that connectedness and separation will be separately and jointly related to indicators of successful identity development. A sample of 968 students attending 7th and 10th grades was drawn to represent different German school tracks.…

  3. Development of the Two Phase Flow Separator Experiment for a Reduced Gravity Aircraft Flight

    Science.gov (United States)

    Golliher, Eric; Gotti, Daniel; Owens, Jay; Gilkey, Kelly; Pham, Nang; Stehno, Philip

    2016-01-01

    The recent hardware development and testing of a reduced gravity aircraft flight experiment has provided valuable insights for the future design of the Two Phase Flow Separator Experiment (TPFSE). The TPFSE is scheduled to fly within the Fluids Integration Rack (FIR) aboard the International Space Station (ISS) in 2020. The TPFSE studies the operational limits of gas and liquid separation of passive cyclonic separators. A passive cyclonic separator utilizes only the inertia of the incoming flow to accomplish the liquid-gas separation. Efficient phase separation is critical for environmental control and life support systems, such as recovery of clean water from bioreactors, for long duration human spaceflight missions. The final low gravity aircraft flight took place in December 2015 aboard NASA's C9 airplane.

  4. Development of regenerative peripheral nerve interfaces for motor control of neuroprosthetic devices

    Science.gov (United States)

    Kemp, Stephen W. P.; Urbanchek, Melanie G.; Irwin, Zachary T.; Chestek, Cynthia A.; Cederna, Paul S.

    2017-05-01

    Traumatic peripheral nerve injuries suffered during amputation commonly results in debilitating neuropathic pain in the affected limb. Modern prosthetic technologies allow for intuitive, simultaneous control of multiple degrees of freedom. However, these state-of-the-art devices require separate, independent control signals for each degree of freedom, which is currently not possible. As a result, amputees reject up to 75% of myoelectric devices preferring instead to use body-powered artificial limbs which offer subtle sensory feedback. Without meaningful and intuitive sensory feedback, even the most advanced myoelectric prostheses remain insensate, burdensome, and are associated with enormous cognitive demand and mental fatigue. The ideal prosthetic device is one which is capable of providing intuitive somatosensory feedback essential for interaction with the environment. Critical to the design of such a bioprosthetic device is the development of a reliable biologic interface between human and machine. This ideal patient-prosthetic interface allows for transmission of both afferent somatosensory information and efferent motor signals for a closed-loop feedback system of neural control. Our lab has developed the Regenerative Peripheral Nerve Interface (RPNI) as a biologic nerve interface designed for stable integration of a prosthetic device with transected peripheral nerves in a residual limb. The RPNI is constructed by surgically implanting the distal end of a transected peripheral nerve into an autogenous muscle graft. Animal experiments in our lab have shown recording of motor signals from RPNI's implanted into both rodents and monkeys. Here, we achieve high amplitude EMG signals with a high signal to noise (SNR) ratio.

  5. Development of Cloud Chamber by Using Peltier Device

    International Nuclear Information System (INIS)

    Woo, Jong Kwan; Kwon, Jin Young; Park, Sang Tae

    2011-01-01

    In this research, we developed the newly cloud chamber apparatus by using Peltier device to apply nuclear physics experiment in high school or university. We observed the cosmic rays track by using the developed apparatus and a camcorder. And we compared and analyzed the acquired data. From the results, we acquired the following conclusions and suggestions : First, it is very difficult to observe the cosmic rays track in the typical cloud chamber because of the low frequency of it. But in the newly developed cloud chamber we can observe easily the cosmic rays track owing to the high frequency of it. Second, when we do the experiment with the newly developed apparatus, we found that the cosmic rays track happens well under the condition that the temperature of the upper place of cooling plate must be below 5 degree Celsius with more than isopropanol 1.04X10 -5 ml.mm -3 . Third, the newly developed apparatus will be improved to have better precision by controlling the temperature of cooling plate in the cloud chamber by current intensity. Therefore we think that it is very useful to use the newly developed apparatus in the nuclear physics experiment in high school or university.

  6. Development of Cloud Chamber by Using Peltier Device

    Energy Technology Data Exchange (ETDEWEB)

    Woo, Jong Kwan [Jae Hyun High School, Seoul (Korea, Republic of); Kwon, Jin Young [Jeon Min High School, Daejeon (Korea, Republic of); Park, Sang Tae [Dept. of Physics Education, Kongju National University, Kongju (Korea, Republic of)

    2011-09-15

    In this research, we developed the newly cloud chamber apparatus by using Peltier device to apply nuclear physics experiment in high school or university. We observed the cosmic rays track by using the developed apparatus and a camcorder. And we compared and analyzed the acquired data. From the results, we acquired the following conclusions and suggestions : First, it is very difficult to observe the cosmic rays track in the typical cloud chamber because of the low frequency of it. But in the newly developed cloud chamber we can observe easily the cosmic rays track owing to the high frequency of it. Second, when we do the experiment with the newly developed apparatus, we found that the cosmic rays track happens well under the condition that the temperature of the upper place of cooling plate must be below 5 degree Celsius with more than isopropanol 1.04X10{sup -5}ml.mm{sup -3}. Third, the newly developed apparatus will be improved to have better precision by controlling the temperature of cooling plate in the cloud chamber by current intensity. Therefore we think that it is very useful to use the newly developed apparatus in the nuclear physics experiment in high school or university.

  7. Development of volume reduction method of cesium contaminated soil with magnetic separation

    International Nuclear Information System (INIS)

    Yukumatsu, Kazuki; Nomura, Naoki; Mishima, Fumihito; Akiyama, Yoko; Nishijima, Shigehiro

    2016-01-01

    In this study, we developed a new volume reduction technique for cesium contaminated soil by magnetic separation. Cs in soil is mainly adsorbed on clay which is the smallest particle constituent in the soil, especially on paramagnetic 2:1 type clay minerals which strongly adsorb and fix Cs. Thus selective separation of 2:1 type clay with a superconducting magnet could enable to reduce the volume of Cs contaminated soil. The 2:1 type clay particles exist in various particle sizes in the soil, which leads that magnetic force and Cs adsorption quantity depend on their particle size. Accordingly, we examined magnetic separation conditions for efficient separation of 2:1 type clay considering their particle size distribution. First, the separation rate of 2:1 type clay for each particle size was calculated by particle trajectory simulation, because magnetic separation rate largely depends on the objective size. According to the calculation, 73 and 89 % of 2:1 type clay could be separated at 2 and 7 T, respectively. Moreover we calculated dose reduction rate on the basis of the result of particle trajectory simulation. It was indicated that 17 and 51 % of dose reduction would be possible at 2 and 7 T, respectively. The difference of dose reduction rate at 2 T and 7 T was found to be separated a fine particle. It was shown that magnetic separation considering particle size distribution would contribute to the volume reduction of contaminated soil

  8. Feedback about Astronomical Application Developments for Mobile Devices

    Science.gov (United States)

    Schaaff, A.; Boch, T.; Fernique, P.; Houpin, R.; Kaestlé, V.; Royer, M.; Scheffmann, J.; Weiler, A.

    2013-10-01

    Within a few years, Smartphones have become the standard for mobile telephony, and we are now witnessing a rapid development of Internet tablets. These mobile devices have enough powerful hardware features to run more and more complex applications. In the field of astronomy it is not only possible to use these tools to access data via a simple browser, but also to develop native applications reusing libraries (Java for Android, Objective-C for iOS) developed for desktops. We have been working for two years on mobile application development and we now have the skills in native iOS and Android development, Web development (especially HTML5, JavaScript, CSS3) and conversion tools (PhoneGap) from Web development to native applications. The biggest change comes from human/computer interaction that is radically changed by the use of multitouch. This interaction requires a redesign of interfaces to take advantage of new features (simultaneous selections in different parts of the screen, etc.). In the case of native applications, the distribution is usually done through online stores (App Store, Google Play, etc.) which gives visibility to a wider audience. Our approach is not only to perform testing of materials and developing of prototypes, but also operational applications. The native application development is costly in development time, but the possibilities are broader because it is possible to use native hardware such as the gyroscope and the accelerometer, to point out an object in the sky. Development depends on the Web browser and the rendering and performance are often very different between different browsers. It is also possible to convert Web developments to native applications, but currently it is better to restrict this possibility to light applications in terms of functionality. Developments in HTML5 are promising but are far behind those available on desktops. HTML5 has the advantage of allowing development independent from the evolution of the mobile

  9. Development of new low activation aluminum alloys for fusion devices

    International Nuclear Information System (INIS)

    Kamada, Kohji; Kakihana, Hidetake.

    1985-01-01

    As the materials for the R facility (a tokamak nuclear fusion device in the R project intended for D-T burning) in the Institute of Plasma Physics, Nagoya University, Al-4 % Mg-0.2 % Bi (5083 improved type) and Al-4 % Mg-1 % Li, aimed at low radioactivability, high electric resistance and high strength, have been developed. The results of the nuclear properties evaluation with 14 MeV neutrons and of the measurements of electric resistance and mechanical properties were satisfactory. The possibility of producing large Al-4 % Mg-1 % Li plate (1 m x 2 m x 25 mm) in the existing factory was confirmed, with the properties retained. The electric resistances were higher than those in the conventional aluminum alloys, and still with feasibility for the further improvement. General properties of the fusion aluminum alloys and the 26 Al formation in (n, 2n) reaction were studied. (Mori, K.)

  10. Development of plastic media blasting device for stud bolt

    International Nuclear Information System (INIS)

    Yoshihisa, Y.; Miyashita, T.

    1999-01-01

    Plastic media blasting is a mechanical cleaning method for removing paint, rust and/or anti-galling material etc on the surface of metal without damaging the metal surface. The method is suitable for cleaning the surface of reusable elements and parts such as bolts and nuts. Anti-galling material such as molybdenum disulfide is applied to fastening stud bolts used for the steam turbine rotor casing. It is necessary to remove this material when new anti-galling material is to be applied. Genden Engineering Services and Construction Co., and Morikawa Industries Corp., have developed a plastic media blasting device to clean the surface of stud bolt screw threads installed in the facility such as lower casing of the turbine. This paper reports the outline of the results. (author)

  11. Development of Pointing Device Using DC-Coupled Electrooculogram

    Science.gov (United States)

    Uchitomi, Hirotaka; Hori, Junichi

    A purpose of this study is to support communication of developmentally disabled individuals with motor paralysis, such as Guillain-Barre Syndrome, brain-stem infarction, having difficulty in conveying their intention. In the present paper, a pointing device controlled by DC-coupled electrooculograms (EOGs) has been developed. The optic angle of the subject was estimated from the amplitude of vertical and horizontal EOGs for determining the two dimensional pointing position on the PC screen in real time. The eye blinking artifact was reduced using a median filter. The displacement of electrode position was compensated by considering the potential gradient. Moreover, the position error caused by drift phenomenon was adjusted by using head movement. The accuracy and operating speed of the proposed method were evaluated in human experiments.

  12. MEMS Device Being Developed for Active Cooling and Temperature Control

    Science.gov (United States)

    Moran, Matthew E.

    2001-01-01

    High-capacity cooling options remain limited for many small-scale applications such as microelectronic components, miniature sensors, and microsystems. A microelectromechanical system (MEMS) is currently under development at the NASA Glenn Research Center to meet this need. It uses a thermodynamic cycle to provide cooling or heating directly to a thermally loaded surface. The device can be used strictly in the cooling mode, or it can be switched between cooling and heating modes in milliseconds for precise temperature control. Fabrication and assembly are accomplished by wet etching and wafer bonding techniques routinely used in the semiconductor processing industry. Benefits of the MEMS cooler include scalability to fractions of a millimeter, modularity for increased capacity and staging to low temperatures, simple interfaces and limited failure modes, and minimal induced vibration.

  13. DEVELOPMENT OF AN ADHESIVE CANDLE FILTER SAFEGUARD DEVICE; F

    International Nuclear Information System (INIS)

    John P. Hurley; Ann K. Henderson; Jan W. Nowok; Michael L. Swanson

    2002-01-01

    In order to reach the highest possible efficiencies in a coal-fired turbine-based power system, the turbine should be directly fired with the products of coal conversion. Two main types of systems employ these turbines: those based on pressurized fluidized-bed combustors and those based on integrated gasification combined cycles. In both systems, suspended particulates must be cleaned from the gas stream before it enters the turbine so as to prevent fouling and erosion of the turbine blades. To produce the cleanest gas, barrier filters are being developed and are in use in several facilities. Barrier filters are composed of porous, high-temperature materials that allow the hot gas to pass but collect the particulates on the surface. The three main configurations of the barrier filters are candle, cross-flow, and tube filters. Both candle and tube filters have been tested extensively. They are composed of coarsely porous ceramic that serves as a structural support, overlain with a thin, microporous ceramic layer on the dirty gas side that serves as the primary filter surface. They are highly efficient at removing particulate matter from the gas stream and, because of their ceramic construction, are resistant to gas and ash corrosion. However, ceramics are brittle and individual elements can fail, allowing particulates to pass through the hole left by the filter element and erode the turbine. Preventing all failure of individual ceramic filter elements is not possible at the present state of development of the technology. Therefore, safeguard devices (SGDs) must be employed to prevent the particulates streaming through occasional broken filters from reaching the turbine. However, the SGD must allow for the free passage of gas when it is not activated. Upon breaking of a filter, the SGD must either mechanically close or quickly plug with filter dust to prevent additional dust from reaching the turbine. Production of a dependable rapidly closing autonomous mechanical

  14. Status of Safeguards and Separations Model Development at Plant and Molecular Levels

    Energy Technology Data Exchange (ETDEWEB)

    de Almeida, Valmor F [ORNL; Hay, Benjamin [ORNL; DePaoli, David W [ORNL

    2009-10-01

    A primary goal of the Safeguards and Separations IPSC effort is the development of process modeling tools that allow dynamic simulations of separations plant operations under various configurations and conditions, and integration of relevant safeguards analyses. A requirement of the effort is to develop codes on modern, expandable architectures, with flexibility to explore and evaluate a wide range of process options. During FY09, efforts at ORNL have been focused on two priority tasks toward achieving the IPSC goal: (1) a top-down exploration of architecture - Subtask 1: Explore framework for code development and integration for plant-level simulation; and (2) a bottom-up fundamental modeling effort - Subtask 2: Development of molecular-level agent design code. Subtask 1 is important because definition and development of architecture is a key issue for the overall effort, as selection of an overall approach and code/data requirements is a necessary first step in the organization, design and development of separations and safeguards codes that will be incorporated. The agent design effort of Subtask 2 is a molecular-level modeling effort that has a direct impact on a near-term issue of the Separations and Waste Forms Campaign. A current focus of experimental efforts is the development of robust agents and processes for separation of Am/Cm. Development of enhanced agent-design codes will greatly accelerate discovery and experimental testing.

  15. Status of Safeguards and Separations Model Development at Plant and Molecular Levels

    International Nuclear Information System (INIS)

    de Almeida, Valmor F.; Hay, Benjamin; DePaoli, David W.

    2009-01-01

    A primary goal of the Safeguards and Separations IPSC effort is the development of process modeling tools that allow dynamic simulations of separations plant operations under various configurations and conditions, and integration of relevant safeguards analyses. A requirement of the effort is to develop codes on modern, expandable architectures, with flexibility to explore and evaluate a wide range of process options. During FY09, efforts at ORNL have been focused on two priority tasks toward achieving the IPSC goal: (1) a top-down exploration of architecture - Subtask 1: Explore framework for code development and integration for plant-level simulation; and (2) a bottom-up fundamental modeling effort - Subtask 2: Development of molecular-level agent design code. Subtask 1 is important because definition and development of architecture is a key issue for the overall effort, as selection of an overall approach and code/data requirements is a necessary first step in the organization, design and development of separations and safeguards codes that will be incorporated. The agent design effort of Subtask 2 is a molecular-level modeling effort that has a direct impact on a near-term issue of the Separations and Waste Forms Campaign. A current focus of experimental efforts is the development of robust agents and processes for separation of Am/Cm. Development of enhanced agent-design codes will greatly accelerate discovery and experimental testing.

  16. Development of an Inclined Plate Extractor-Separator for Immiscible Liquids

    Directory of Open Access Journals (Sweden)

    Syed Zahoor ul Hassan Rizvi

    2009-10-01

    Full Text Available A new inclined plates extractor-separator is developed for operation with immiscible liquids in which extraction and separation is achieved in one unit contrary to mixer settlers. The inclined plates extractor-separator combines turbulent jets for contacting, and an inclined plate for separation of the two phases. The inclined plates extractor-separator does not have any moving part inside the vessel. This feature makes it free from the mechanical problems associated with conventional apparatus. The proposed inclined plates extractor-separator was operated in batch mode under various operating conditions to evaluate its performance on the basis of extraction efficiency. Water (light phase was used as solvent to extract ethyl acetate from a heavy phase pool of tetrachloroethylene and ethyl acetate. The ethyl acetate content was analysed using chromatography. A hydrodynamic study was carried out using high speed photography to understand the mechanisms occurring during mass transfer across the two phases. Furthermore, it was found that the proposed inclined plate extractor-separator reduces the overall operating time by 67% and consumes only 13% of the power in comparison to a mixer-settler. A hydraulic power consumption comparison with a mixer settler and a gullwing extractor-separator is also presented.

  17. Mobile Game Development for Multiple Devices in Education

    Directory of Open Access Journals (Sweden)

    Baltasar Fernández-Manjón

    2009-10-01

    Full Text Available Mobile learning and educational gaming are two trends that are rapidly having an increasing impact in Technology-Enhanced Learning. However, both approaches present significant technological challenges. Mobile technologies are very diverse and the market pressure pushes the continuous development of new technologies and features. On the other hand, game-based learning needs to deal with enormous development costs and the problem of allowing instructors and experts to actively participate in the game development process. Moreover, there are numerous situations where bringing both approaches together could be very useful, but this combination magnifies the technological barriers previously described. In this work we present , an authoring environment for educational adventure games that supports the production of both desktop and mobile games. This framework provides a graphical environment that allows instructors to create their own educational games with a low cost. Then, the games can be exported to multiple formats, including support for diverse types of mobile platforms. This is achieved through a modular semi-automated exportation process, which is based on mobile device profiles.

  18. Process and device to set a separated helicoid thread in a large diameter tapped hole and use of this process and device

    International Nuclear Information System (INIS)

    Dworaczek, J.P.; Grypczynski, D.

    1992-01-01

    In a PWR reactor the vessel head is fixed to the reactor vessel by the vessel flange and closure studs. If the thread machined in the vessel flange is damaged or worn out, a separate thread, rolled up on a tapped drum is screwed in the tapped opening and the thread is fixed by a pin

  19. Dynamic considerations in the development of centrifugal separators used for reprocessing nuclear fuel

    International Nuclear Information System (INIS)

    Strunk, W.D.; Singh, S.P.; Tuft, R.M.

    1988-01-01

    The development of centrifugal separators has been a key ingredient in improving the process used for reprocessing of spent nuclear fuel. The separators are used to segregate uranium and plutonium from the fission products produced by a controlled nuclear reaction. The separators are small variable speed centrifuges, designed to operate in a harsh environment. Dynamic problems were detected by vibration analysis and resolved using modal analysis and trending. Problems with critical speeds, resonances in the base, balancing, weak components, precision manufacturing, and short life have been solved

  20. Development of membrane moisture separator for BWR off-gas system

    International Nuclear Information System (INIS)

    Ogata, H.; Kawamura, S.; Kumasaka, M.; Nishikubo, M.

    2001-01-01

    In BWR plant off-gas treatment systems, dehumidifiers are used to maintain noble gas adsorption efficiency in the first half of the charcoal hold-up units. From the perspective of simplifying and reducing the cost of such a dehumidification system, Japanese BWR utilities and plant fabricators have been developing a dehumidification system employing moisture separation membrane of the type already proven in fields such as medical instrumentation and precision measuring apparatus. The first part of this development involved laboratory testing to simulate the conditions found in an actual off-gas system, the results of which demonstrated satisfactory results in terms of moisture separation capability and membrane durability, and suggested favorable prospects for application in actual off-gas systems. Further, in-plant testing to verify moisture separation capability and membrane durability in the presence of actual gases is currently underway, with results so far suggesting that the system is capable of obtaining good moisture separation capability. (author)

  1. Development and Application of Devices for Remote Monitoring of Gamma-Ray Contamination at RECOM Ltd

    International Nuclear Information System (INIS)

    Ivanov, O.P.; Stepanov, V.E.; Chesnokov, A.V.; Sudarkin, A.N.; Urutskoev, L.I.

    1999-01-01

    Devices for remote monitoring of gamma-ray contamination develop at RECOM Ltd. are described and typical examples of their application are show. The following devices are discussed: spectrum-sensitive collimated devices for mapping of radioactivity on contaminated surfaces- scanning collimated Gamma Locator, device for field Cs-137 contamination mapping-CORAD; devices for gamma-ray imaging computer-controlled High-Energy Radiation Visualizer (HERV) and Coded Mask Imager

  2. Plasma processing of soft materials for development of flexible devices

    International Nuclear Information System (INIS)

    Setsuhara, Yuichi; Cho, Ken; Takenaka, Kosuke; Shiratani, Masaharu; Sekine, Makoto; Hori, Masaru

    2011-01-01

    Plasma-polymer interactions have been studied as a basis for development of next-generation processing of flexible devices with soft materials by means of low-damage plasma technologies (soft materials processing technologies). In the present article, interactions between argon plasmas and polyethylene terephthalate (PET) films have been examined for investigations of physical damages induced by plasma exposures to the organic material via chemical bonding-structure analyses using hard X-ray photoelectron spectroscopy (HXPES) together with conventional X-ray photoelectron spectroscopy (XPS). The PET film has been selected as a test material for investigations in the present study not merely because of its specific applications, such as a substrate material, but because PET is one of the well defined organic materials containing major components in a variety of functional soft materials; C-C main chain, CH bond, oxygen functionalities (O=C-O bond and C-O bond) and phenyl group. Especially, variations of the phenyl group due to argon plasma exposures have been investigated in the present article in order to examine plasma interactions with π-conjugated system, which is in charge of electronic functions in many of the π-conjugated electronic organic materials to be utilized as functional layer for advanced flexible device formations. The PET films have been exposed to argon plasmas sustained via inductive coupling of RF power with low-inductance antenna modules. The HXPES analyses exhibited that the degradations of the oxygen functionalities and the phenyl group in the deeper regions up to 50 nm from the surface of the samples were insignificant indicating that the bond scission and/or the degradations of the chemical bonding structures due to photoirradiation from the plasma and/or surface heating via plasma exposure were relatively insignificant as compared with damages in the vicinity of the surface layers.

  3. ELGA and TOR installations control device to carry out experiments on-line with a mass-separator by the ASNAPP-2 code

    International Nuclear Information System (INIS)

    Arvai, Z.; Guyash, Ya.; Kuznetsov, V.V.; Fominykh, V.I.

    1984-01-01

    The control device of the tor beta-spectrometer with toroidal magnetic field and the ELGA spectrometer with semiconductor detectors for investigation of conversion electrons, positrons, γ- and α-radiations and lifetime of excited states and periods of isotopes half-decay are described. The block-diagram of the measurement processes, algorithm of the ELGA devce operation, control device circuit, and circuit for connection of analog-to-digital converter with the CAMAC dataway, block-diagram of step motor control, and step motor feeding scheme as well as mechanical and electrical characteristics of the step motor are given. The device is used for spectroscopic investigations of short-lived isotopes on the accelerator proton beam with mass separator

  4. Design and Development of Selective Extractants for Ln/An Separations

    International Nuclear Information System (INIS)

    Paine, Robert T.

    2009-01-01

    This study has succeeded in further developing phosphinoylmethyl pyridine compounds as selective recognition and separations agents for trivalent lanthanide and actinide ions present in nuclear materials. The parameters for efficient separations have been further elucidated and factors important to further development have been identified. Further development will lead to optimal extractant design for effective actinide ion partitioning under process practical conditions. The primary objective of the project involved the design, synthesis, and characterization of the extraction performance of 2,6-bis(phosphinomethyl)pyridine N,P,P'-trioxides (NOPOPO) as potential reagents for the separation of Am, Cm, and fission product lanthanides from other transuranics and fission products and for acting as a separations 'platform' for the mutual separation of Am/Cm from the lanthanides. The secondary but critical objective of the project focused on the characterization of aqueous acid and radiation stability of NOPOPO ligands. Further, the project served as a interdisciplinary training vehicle for new, young investigators in actinide separations chemistry.

  5. Development of irradiation support devices for production of brachytherapy seeds

    Energy Technology Data Exchange (ETDEWEB)

    Mattos, Fabio R.; Rostelato, Maria Elisa C.M.; Zeituni, Carlos A.; Souza, Carla D.; Moura, Joao A.; Peleias Junior, Fernando S.; Karan Junior, Dib; Feher, Anselmo; Oliveira, Tiago B.; Benega, Marcos A.G., E-mail: tiagooliveira298@gmail.com, E-mail: mattos.fr@gmail.com, E-mail: elisaros@ipen.br, E-mail: czeituni@ipen.br, E-mail: carladdsouza@yahoo.com.br, E-mail: jamoura@ipen.br, E-mail: ernandopeleias@gmail.com, E-mail: s, E-mail: dib.karan@usp.br, E-mail: afeher@ipen.br, E-mail: marcosagbenega@gmail.com [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    Ophthalmic tumors treatment with brachytherapy sources has been widely used as a primary or secondary therapy for non-malignant or malignant tumors, for example, choroid melanoma, and retinoblastoma. Ruthenium-106, Iodine-125, Palladium -103, Gold-198 and Iridium-192, are some radionuclides that can be applied for treatment of ocular tumors. These sources are in small sizes (a few millimeters) and different shapes (rods, wires, disks). To ensure high accuracy during treatment, they are positioned in eye applicators, specially designed to fit on the surface of tumor. The Nuclear and Energy Research Institute (IPEN/CNEN) in a partnership with Paulista Medicine School (UNIFESP) created a project that aims to develop a prototype of Iridium-192 seeds for treatment of eye cancer. This seed consists in a core of Ir -Pt alloy (20%-80%) with a length of 3 mm, to be activated in IPEN's IEA-R1 Reactor, and a titanium capsule sealing the core. It was imperative to develop a sustainer device for irradiation. This piece is used to avoid overlapping of one cores and, therefore, avoiding the 'shadow effect' that does not allow full activation of each core due to the high density. (author)

  6. Development of irradiation support devices for production of brachytherapy seeds

    International Nuclear Information System (INIS)

    Mattos, Fabio R.; Rostelato, Maria Elisa C.M.; Zeituni, Carlos A.; Souza, Carla D.; Moura, Joao A.; Peleias Junior, Fernando S.; Karan Junior, Dib; Feher, Anselmo; Oliveira, Tiago B.; Benega, Marcos A.G.

    2013-01-01

    Ophthalmic tumors treatment with brachytherapy sources has been widely used as a primary or secondary therapy for non-malignant or malignant tumors, for example, choroid melanoma, and retinoblastoma. Ruthenium-106, Iodine-125, Palladium -103, Gold-198 and Iridium-192, are some radionuclides that can be applied for treatment of ocular tumors. These sources are in small sizes (a few millimeters) and different shapes (rods, wires, disks). To ensure high accuracy during treatment, they are positioned in eye applicators, specially designed to fit on the surface of tumor. The Nuclear and Energy Research Institute (IPEN/CNEN) in a partnership with Paulista Medicine School (UNIFESP) created a project that aims to develop a prototype of Iridium-192 seeds for treatment of eye cancer. This seed consists in a core of Ir -Pt alloy (20%-80%) with a length of 3 mm, to be activated in IPEN's IEA-R1 Reactor, and a titanium capsule sealing the core. It was imperative to develop a sustainer device for irradiation. This piece is used to avoid overlapping of one cores and, therefore, avoiding the 'shadow effect' that does not allow full activation of each core due to the high density. (author)

  7. Underwater Shock Wave Research Applied to Therapeutic Device Developments

    Science.gov (United States)

    Takayama, K.; Yamamoto, H.; Shimokawa, H.

    2013-07-01

    The chronological development of underwater shock wave research performed at the Shock Wave Research Center of the Institute of Fluid Science at the Tohoku University is presented. Firstly, the generation of planar underwater shock waves in shock tubes and their visualization by using the conventional shadowgraph and schlieren methods are described. Secondly, the generation of spherical underwater shock waves by exploding lead azide pellets weighing from several tens of micrograms to 100 mg, that were ignited by irradiating with a Q-switched laser beam, and their visualization by using double exposure holographic interferometry are presented. The initiation, propagation, reflection, focusing of underwater shock waves, and their interaction with various interfaces, in particular, with air bubbles, are visualized quantitatively. Based on such a fundamental underwater shock wave research, collaboration with the School of Medicine at the Tohoku University was started for developing a shock wave assisted therapeutic device, which was named an extracorporeal shock wave lithotripter (ESWL). Miniature shock waves created by irradiation with Q-switched HO:YAG laser beams are studied, as applied to damaged dysfunctional nerve cells in the myocardium in a precisely controlled manner, and are effectively used to design a catheter for treating arrhythmia.

  8. Development and technical implementation of the separation nozzle process for enrichment of uranium 235

    International Nuclear Information System (INIS)

    Syllus Martins Pinto, C.; Voelcker, H.; Becker, E.W.

    1977-12-01

    The separation nozzle process for the enrichment of uranium-235 has been developed at the Karlsruhe Nuclear Research Center as an alternative to the gaseous diffusion and centrifuge process. The separation of uranium isotopes is achieved by the deflection of a jet of uranium hexafluoride mixed with hydrogen. Since 1970, the German company of STEAG, has been involved in the technological development and commercial implementation of the nozzle process. In 1975, the Brazilian company of NUCLEBRAS, and the German company of Interatom, joined the effort. The primary objective of the common activity is the construction of a separation nozzle demonstration plant with an annual capacity of about 200 000 SWU and the development of components of a commercial plant. The paper covers the most important steps in the development and the technical implementation of the process. (orig.) [de

  9. Development of Magnetic Nanomaterials and Devices for Biological Applications

    Science.gov (United States)

    2007-10-30

    analysis. Suitable crystals for the X-ray diffraction analysis were grown as dark red plates from a saturated hexane solution of [ Co3 (CO)9CCH3] at 4 ºC...Commercially available magnetic nanoparticles are suitable for cell separation where a large number of particles are used to separate a single cell...from a sample. The magnetic moment of these particles is not high enough to enable the separation of single antigen molecules using a single particle

  10. Development of a water separator for steam drying in nuclear power plants

    International Nuclear Information System (INIS)

    Kall, H.

    1979-01-01

    In the wet steam of nuclear power plants with light water cooling the content of liquid phase before entering the high- and low-pressure turbine or at the inlet of the reheater connected in between is limited to a few parts per thousand. For the mechanical drying necessary to maintain this moisture limit there is suited the socalled lamellar separator, in which the vertical laminae, arranged one beside the other, confine a great number of separating ducts, bended in periodically changing sequence, through which wet steam is flowing. In the development of such a lamellar separator with internal drain channels described in this paper the droplet motion in the carrier gas stream and the discharge of the separated liquid is treated independently from each other. The mathematical and experimental study of the first-mentioned partial process leads to its complete description in a dimensionless separation diagram. During the subsequent discharge of the primarily separated droplet fluid there may be torn off droplets by the steam flow and carried away from the separator.The limit for the draining capacity reached with the occurrence of this phenomenon was determined in preliminary experiments with air and water and in experiments with wet steam carried out close to operating conditions. (orig.) 891 GL/orig. 892 RRD [de

  11. Development of a Systems Engineering Model of the Chemical Separations Process

    International Nuclear Information System (INIS)

    Sun, Lijian; Li, Jianhong; Chen, Yitung; Clarksean, Randy; Ladler, Jim; Vandergrift, George

    2002-01-01

    Work is being performed to develop a general-purpose systems engineering model for the AAA separation process. The work centers on the development of a new user interface for the AMUSE code and on the specification of a systems engineering model. This paper presents background information and an overview of work completed to date. (authors)

  12. Development of a Novel Self-Enclosed Sample Preparation Device for DNA/RNA Isolation in Space

    Science.gov (United States)

    Zhang, Ye; Mehta, Satish K.; Pensinger, Stuart J.; Pickering, Karen D.

    2011-01-01

    Modern biology techniques present potentials for a wide range of molecular, cellular, and biochemistry applications in space, including detection of infectious pathogens and environmental contaminations, monitoring of drug-resistant microbial and dangerous mutations, identification of new phenotypes of microbial and new life species. However, one of the major technological blockades in enabling these technologies in space is a lack of devices for sample preparation in the space environment. To overcome such an obstacle, we constructed a prototype of a DNA/RNA isolation device based on our novel designs documented in the NASA New Technology Reporting System (MSC-24811-1/3-1). This device is self-enclosed and pipette free, purposely designed for use in the absence of gravity. Our design can also be modified easily for preparing samples in space for other applications, such as flowcytometry, immunostaining, cell separation, sample purification and separation according to its size and charges, sample chemical labeling, and sample purification. The prototype of our DNA/RNA isolation device was tested for efficiencies of DNA and RNA isolation from various cell types for PCR analysis. The purity and integrity of purified DNA and RNA were determined as well. Results showed that our developed DNA/RNA isolation device offers similar efficiency and quality in comparison to the samples prepared using the standard protocol in the laboratory.

  13. Long-term program for research and development of group separation and disintegration techniques

    International Nuclear Information System (INIS)

    1988-01-01

    In Japan, the basic guidelines state that high-level radioactive wastes released from reprocessing of spent fuel should be processed into stable solid material, followed by storage for cooling for 30-50 years and disposal in the ground at a depth of several hundreds of meters. The Long-Term Program for Research and Development of Group Separation and Disintegration Techniques is aimed at efficient disposal of high-level wastes, reutilization of useful substances contained, and improved safety. Important processes include separation of nuclides (group separation, individual nuclide separation) and conversion (disintegration) of long-lived nuclides into short-lived or non-radioactive one. These processes can reduce the volume of high-level wastes to be left for final disposal. Research and development projects have been under way to provide techniques to separate high-level waste substances into four groups (transuranic elements, strontium/cesium, technetium/platinum group elements, and others). These projects also cover recovery of useful metals and efficient utilization of separated substances. For disintegration, conceptual studies have been carried out for the application of fast neutron beams to conversion of long half-life transuranium elements into short half-life or non-radioactive elements. (N.K.)

  14. The contribution of photosynthetic pigments to the development of biochemical separation methods: 1900-1980.

    Science.gov (United States)

    Albertsson, Per-Ake

    2003-01-01

    The role of photosynthetic pigments in the development of separation methods in biochemistry during the period 1900-1980 is described beginning with M. Tswett who introduced separation of chlorophylls and carotenoids on columns and coined the term chromatography in 1906. In Uppsala, T. Svedberg developed the ultracentrifuge in the 1920s. A. Tiselius improved electrophoresis in the 1930s and developed chromatography of proteins in the 1940s and 1950s. Others of 'The Uppsala school in separation science' include J. Porath, P. Flodin and S. Hjertén who further developed various gel chromatographic methods. Hjertén introduced free zone electrophoresis in narrow tubes, a forerunner of capillary electrophoresis. Two proteins, phycoerythrin and phycocyanin, were used as test substances in all these methodological studies. Aqueous two-phase partitioning as a separation method was introduced in 1956 by the author. In this work, chloroplast particles were used, and the method was applied for the separation and purification of intact chloroplasts, inside-out thylakoid vesicles and plasma membranes. My research was carried out in cooperation with G. Blomquist, G. Johansson, C. Larsson, B. Andersson and H.-E. Akerlund during a 20-year period, 1960-1980.

  15. Development of Enhanced Window layers for CIGS Photovoltaic Devices

    Science.gov (United States)

    Alexander, J. Nicholas

    One of the most promising thin film devices right now is the Copper Indium Gallium Selenide (CIGS) solar cell with maximum reported power conversion efficiency of 22.3%. The Transparent Conducting Oxide (TCO) which is the top layer of the CIGS device also known as the window layer, is responsible for collecting the electrons generated in the CIGS device and conducting them to the circuit. Development of a very low resistivity film with a high optical transmission is crucial for optimal performance of devices as well as the ability to be deployed without changes to their properties for several decades. Current TCOs such as indium tin oxide (ITO) and aluminum doped zinc oxide (AZO) are met with limitations with either using large amounts of expensive materials such as indium, often requiring and anneal step to obtain good conductivity, or have shown poor long term reliability. This thesis is focused on development of InZnO and zirconium doped InZnO as a potential replacement TCO to obtain high conductivity and high transmission like the leading TCOs without needing heated depositions, post deposition annealing, and maintain a good film reliability. Zirconium doping was employed to farther enhance both the optical and electrical properties through enhancement of the films high frequency permittivity of InZnO while providing improved reliability to the film. The films were grown through a mix of DC and RF co-sputtering. InZnO films were deposited at varying indium concentration ( 10-30%) and samples were able to achieve low resistivity ( 7x10-4 O-cm), high mobility (>30 cm2/v.s), high carrier concentration (>10 20 cm-3), while maintaining high transmission (> 80%) in the visible and near-infrared region. After zirconium was incorporated into the InZnO films by replacement of the ZnO target with a ZrO2/ZnO (5:95) target, films of Zr:InZnO were deposit through the same method to achieve films that maintained very similar electrical and optical properties. The little

  16. 'Blue bubble' technique: an ab interno approach for Descemet separation in deep anterior lamellar keratoplasty using trypan blue stained viscoelastic device.

    Science.gov (United States)

    Livny, Eitan; Bahar, Irit; Hammel, Naama; Nahum, Yoav

    2018-04-01

    In this study, we examined a novel variant of 'big-bubble' deep anterior lamellar keratoplasty using trypan-blue-stained viscoelastic device for the creation of a pre-descemetic bubble. Ten corneoscleral rims were mounted on an artificial anterior chamber (AC). The AC was filled with air through a limbal paracentesis. A Melles' triangulated spatula was inserted through the paracentesis, with its tip penetrating the AC, was then slightly retracted and pushed into the deep stroma above the roof of the paracentesis. A mixture of trypan blue and viscoelastic device (Healon, Abbott Medical Optics, Abbott Park, Illinois) was injected into this intra-stromal pocket using a 27-G cannula to create a pre-descemetic separation bubble. Bubble type and visualization of dyed viscoelastic device were noted. The method was later employed in three cases. In all 10 corneoscleral rims, the technique successfully created a visible pre-descemetic (type 1) bubble that could be expanded up to the predicted diameter of trephination. Subsequent trephination and the removal of corneal stroma were uneventful. In two out of four clinical cases, a type 1 bubble was created, while in two others, visco-dissection failed and dyed viscoelastic was seen in the AC. The presented technique holds promise of being a relatively easy to perform, predictable and well-controlled alternative for achieving a type 1 bubble during deep anterior lamellar keratoplasty surgery. The trypan-blue-stained viscoelastic device facilitates proper visualization and control of the separation bubble and assists in identifying the penetrance to the separation bubble prior to removal of the stromal cap. © 2017 Royal Australian and New Zealand College of Ophthalmologists.

  17. Sb(III) and Sb(V) separation and analytical speciation by a continuous tandem on-line separation device in connection with inductively coupled plasma atomic emission spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Menendez Garcia, A. [Oviedo Univ. (Spain). Dept. of Phys. and Anal. Chem.; Perez Rodriguez, M.C. [Oviedo Univ. (Spain). Dept. of Phys. and Anal. Chem.; Sanchez Uria, J.F. [Oviedo Univ. (Spain). Dept. of Phys. and Anal. Chem.; Sanz-Medel, A. [Oviedo Univ. (Spain). Dept. of Phys. and Anal. Chem.

    1995-09-01

    A sensitive, precise and automated non-chromatographic method for Sb(III) and Sb(V) analytical speciation based on a continuous tandem on-line separation device in connection with inductively coupled plasma-atomic emission (ICP-AES) detection is proposed. Two on-line successive separation steps are included into this method: a continuous liquid-liquid extraction of Sb(III) with ammonium pyrrolidine dithiocarbamate (APDC) into methylisobuthylketone (MIBK), followed by direct stibine generation from the organic phase. Both separation steps are carried out in a continuous mode and on-line with the ICP-AES detector. Optimization of experimental conditions for the tandem separation and ICP-AES detection are investigated in detail. Detection limits for Sb(III) were 3 ng.mL{sup -1} and for Sb(V) 8 ng.mL{sup -1}. Precisions observed are in the range {+-} 5%. The proposed methodology has been applied to Sb(III) and Sb(V) speciation in sea-water samples. (orig.)

  18. All-polymer bistable resistive memory device based on nanoscale phase-separated PCBM-ferroelectric blends

    KAUST Repository

    Khan, Yasser; Bhansali, Unnat Sampatraj; Cha, Dong Kyu; Alshareef, Husam N.

    2012-01-01

    All polymer nonvolatile bistable memory devices are fabricated from blends of ferroelectric poly(vinylidenefluoride-trifluoroethylene (P(VDF-TrFE)) and n-type semiconducting [6,6]-phenyl-C61-butyric acid methyl ester (PCBM). The nanoscale phase

  19. Design principle for efficient charge separation at the donor-acceptor interface for high performance organic solar cell device

    Science.gov (United States)

    Nie, Wanyi; Gupta, Gautam; Crone, Brian; Wang, Hsing-Lin; Mohite, Aditya; MPA-11 Material synthesis and integrated device Team; MPA-chemistry Team

    2014-03-01

    The performance of donor (D) /acceptor (A) structure based organic electronic devices, such as solar cell, light emitting devices etc., relays on the charge transfer process at the interface dramatically. In organic solar cell, the photo-induced electron-hole pair is tightly bonded and will form a charge transfer (CT) state at the D/A interface after dissociation. There is a large chance for them to recombine through CT state and thus is a major loss that limit the overall performance. Here, we report three different strategies that allow us to completely suppress the exciplex (or charge transfer state) recombination between any D/A system. We observe that the photocurrent increases by 300% and the power conversion efficiency increases by 4-5 times simply by inserting a spacer layer in the form of an a) insulator b) Oliogomer or using a c) heavy atom at the donor-acceptor interface in a P3HT/C60 bilayer device. By using those different functional mono layers, we successfully suppressed the exciplex recombination in evidence of increased photocurrent and open circuit voltage. Moreover, these strategies are applicable universally to any donor-acceptor interface. And we demonstrated such strategies in a bulk-heterojunction device which improved the power conversion efficiency from 3.5% up to 4.6%.

  20. Development of sensitive holographic devices for physiological metal ion detection

    Science.gov (United States)

    Sabad-e.-Gul; Martin, Suzanne; Cassidy, John; Naydenova, Izabela

    2017-08-01

    The development of selective alkali metal ions sensors in particular is a subject of significant interest. In this respect, the level of blood electrolytes, particularly H+, Na+, K+ and Cl- , is widely used to monitor aberrant physiologies associated with pulmonary emphysema, acute and chronic renal failure, heart failure, diabetes. The sensors reported in this paper are created by holographic recording of surface relief structures in a self-processing photopolymer material. The structures are functionalized by ionophores dibenzo-18-crown-6 (DC) and tetraethyl 4-tert-butylcalix[4]arene (TBC) in plasticised polyvinyl chloride (PVC) matrix. Interrogation of these structures by light allows indirect measurements of chemical analytes' concentration in real time. We present results on the optimisation and testing of the holographic sensor. A self-processing acrylamide-based photopolymer was used to fabricate the required photonic structures. The performance of the sensors for detection of K+ and Na+ was investigated. It was observed that the functionalisation with DC provides a selective response of the devices to K+ over Na+ and TBC coated surface structures are selectively sensitive to Na+. The sensor responds to Na+ within the physiological ranges. Normal levels of Na+ and K+ in human serum lie within the ranges 135-148mM and 3.5-5.3 mM respectively.

  1. Using of dimensional analysis to determine the parameters of gravity separator table device to minimize impurities in bulk lentils

    Directory of Open Access Journals (Sweden)

    H Bagheri

    2017-05-01

    Full Text Available Introduction Lentil (Lens culinaris medic is an important and highly nutritious crop belonging to the family of legumes. Lentil is cultivated worldwide but competition with weeds is a problem affecting production and can reduce yield by more than 80%. The study on the separation of impurities in bulk lentils (Euphorbia helioscopia weed, Wild oat weed and etc. by a gravity separator has an extreme importance. Since no study has been done to date, in this study, the effects of different parameters of a gravity separator (longitudinal and latitudinal slopes, oscillation frequency and amplitude on the separation of foreign matters in lentil seeds were evaluated. A dimensionless number (v/aω which shows ration of air current velocity blown to lentil to the maximum velocity of table oscillation, was considered in ratio of separation. Materials and Methods In this research, lentil samples were taken from farms in Ardebil Province (Bileh-Savar cultivar. A gravity separator apparatus was also used for separating impurities from lentil seeds. A Laboratory Gravity Separator Type LA-K (Westrup A/S Denmark was used to separate impurities from bulk lentils. In this machine, table settings were as follows; longitudinal slope parameters (1°,1.5°, 1.75°, 2° and 2.5°, latitudinal slope (0.5°, 1°, and 1.5°, frequency of oscillation (380, 400, 420 and 450 cycles min-1, and amplitude of oscillation (5 and 7 mm, these settings were all adjustable. Similarly, the instrument had 5 boxes whereby, through proper adjustment, the heavier material was transferred toward the right side of the table and lighter material moved toward the left side. Through proper adjustment of the main parameters of the instrument, the impurities were separated from bulk lentils. Then using an electronic seed counter, five groups of seed which each group containing 100 seeds were counted and selected. Results and Discussion The results of variance analysis of the factorial design with

  2. Chalcogenide Glass Radiation Sensor; Materials Development, Design and Device Testing

    Energy Technology Data Exchange (ETDEWEB)

    Mitkova, Maria; Butt, Darryl; Kozicki, Michael; Barnaby, Hugo

    2013-04-30

    studied the effect of x-rays and γ-rays, on thin film chalcogenide glasses and applied them in conjunction with film incorporating a silver source in a new type of radiation sensor for which we have an US patent application [3]. In this report, we give data about our studies regarding our designed radiation sensor along with the testing and performance at various radiation doses. These studies have been preceded by materials characterization research related to the compositional and structural characteristics of the active materials used in the radiation sensor design. During the work on the project, we collected a large volume of material since every experiment was repeated many times to verify the results. We conducted a comprehensive material research, analysis and discussion with the aim to understand the nature of the occurring effects, design different structures to harness these effects, generated models to aid in the understanding the effects, built different device structures and collected data to quantify device performance. These various aspects of our investigation have been detailed in previous quarterly reports. In this report, we present our main results and emphasize on the results pertaining to the core project goals materials development, sensor design and testing and with an emphasis on classifying the appropriate material and design for the optimal application. The report has three main parts: (i) Presentation of the main data; (ii) Bulleted summary of the most important results; (iii) List of the patent, journal publications, conference proceedings and conferences participation, occurring as a result of working on the project.

  3. WORKSHOP ON NEW DEVELOPMENTS IN CHEMICAL SEPARATIONS FROM COMBINATORIAL CHEMISTRY AND RELATED SYNTHETIC STRATEGIES

    Energy Technology Data Exchange (ETDEWEB)

    Weber, Stephen G. [University of Pittsburgh, Pittsburgh, Pennsylvania

    1998-08-22

    The power of combinatorial chemistry and related high throughput synthetic strategies is currently being pursued as a fruitful way to develop molecules and materials with new properties. The strategy is motivated, for example in the pharmaceutical industry, by the difficulty of designing molecules to bind to specific sites on target biomolecules. By synthesizing a variety of similar structures, and then finding the one that has the most potent activity, new so-called lead structures will be found rapidly. Existing lead structures can be optimized. This relatively new approach has many implications for separation science. The most obvious is the call for more separations power: higher resolution, lower concentrations, higher speed. This pressure butresses the traditional directions of research into the development of more useful separations. The advent of chip-based, electroosmotically pumped systems1 will certainly accelerate progress in this traditional direction. The progress in combinatorial chemistry and related synthetic strategies gives rise to two other, broadly significant possibilities for large changes in separation science. One possibility results from the unique requirements of the synthesis of a huge number of products simultaneously. Can syntheses and separations be designed to work together to create strategies that lead to mixtures containing only desired products but without side products? The other possibility results from the need for molecular selectivity in separations. Can combinatorial syntheses and related strategies be used in the development of better separations media? A workshop in two parts was held. In one half-day session, pedagogical presentations educated across the barriers of discipline and scale. In the second half-day session, the participants broke into small groups to flesh out new ideas. A panel summarized the breakout discussions.

  4. Development of a portable, automated system for the separation of radionuclides by column chromatography

    International Nuclear Information System (INIS)

    Schumacher, C.; Burow, M.; Flucht, R.; Hill, P.; Zoriy, M.V.

    2012-01-01

    The determination of the chemical recovery is one of the most important challenges in the radiochemical analysis. Small changes at the pH-value and temperature changes lead to uncontrollable conditions in process. To improve the reproducibility of the chemical determination a separate separating column system (TSM) was developed at the analytic laboratory at JUeLICH. Using the TSM it is possible to separate nuclides by applying variable eluents and ion exchangers also in samples with a very high salt content like urine. Up to now the methods are developed for the elements U, Am and Pu. The automation provides a bigger number of analysed samples per working day and a remarkable economy of time. Due to the increasing of the sample volume it is possible to improve the detection limit of overall analytical procedure (time needed for separation increases). Experimental parameters like rate of flow and chemical recovery were tested. In this progress it was tried to develop a dense portable system which is easy to use. This new TSM allows a realisation of various separating processes by the easy handling via laptop. (orig.)

  5. A newly developed oval-shaped port device (E•Z ACCESS Oval type) for use in reduced port surgery: initial clinical experiences with cholecystectomy.

    Science.gov (United States)

    Shibao, Kazunori; Takagi, Tsuyoshi; Higure, Aiichiro; Yamaguchi, Koji

    2013-09-01

    We recently developed an oval-shaped E•Z Access device designed exclusively for use with the LAP PROTECTOR™ Oval type device (Hakko Co. Ltd., Tokyo, Japan). The transverse abdominal opening diameter made by round-shaped (Alexis® Wound Retractor, Applied Medical, Rancho Santa Margarita, CA; and LAP PROTECTOR™ Round type) and oval-shaped (LAP PROTECTOR™ Oval type) wound retractors was measured and compared in 5 patients with cholecystolithiasis. Each device was placed through a single 25-mm longitudinal umbilical incision, and the length of trocar separation was compared. LESS cholecystectomy was then performed using the oval-shaped E•Z ACCESS/LAP PROTECTOR™. The transverse abdominal opening diameter was maximized with the LAP PROTECTOR™ Oval type device. The average distance between the working-ports for the glove method, round-shaped, and oval-shaped E•Z ACCESS/LAP PROTECTOR™ devices in the 25-mm umbilical incisions were 20 ± 0.8 mm, 24 ± 1.5 mm, and 35 ± 0.8 mm, respectively. Wider trocar separation was achieved using the oval-shaped device, making the surgical procedures easier to perform. No perioperative port-related or surgical complications were observed. LESS cholecystectomy using the E•Z ACCESS Oval type device was found to be technically feasible. The Oval type device appears to allow for wider trocar separation, thereby reducing stress on the surgeon, ensuring patient safety, and providing cosmetic benefits.

  6. Development of a Soundproof Device for 950 Watt rated Portable ...

    African Journals Online (AJOL)

    Dr. N.A Musa

    ABSTRACT: The noise emanating from generators has adverse effects on ... soundproof device was carried out, and the sound pressure level of the ... Heat resistance rubber pipe and. 8. ... attached to the exhaust of the generator, respectively.

  7. [Development of Biliary Contrast Agents Remote Pushing Device].

    Science.gov (United States)

    Zhu, Haoyang; Dong, Dinghui; Luo, Yu; Ren, Fenggang; Zhang, Jing; Tan, Wenjun; Shi, Aihua; Hu, Liangshuo; Wu, Rongqian; Lyu, Yi

    2018-01-30

    A biliary contrast agents pushing device, including a syringe pushing system and a remote controller is introduced. The syringe pushing system comprises an injector card slot, a support platform and an injection bolus fader. A 20 mL syringe can be fitted on the syringe pushing system and kept with the ground about 30 degree. This system can perform air bubble pumping back and contrast agents bolus injection as well as speed adjustment. Remote controller is an infrared remote control which can start and stop the syringe pushing system. With this device, the remote controlled cholangiography technology can be achieved, which can not only protect doctors from X-ray radiation but also improve the traditional T-tube cholangiography and the contrast effect, reduce postoperative complications in patients as well. The application of this device will improve the current diagnosis and treatment system, the device will benefit the majority of doctors and patients.

  8. Energy sustainable development through energy efficient heating devices and buildings

    International Nuclear Information System (INIS)

    Bojic, M.

    2006-01-01

    Energy devices and buildings are sustainable if, when they operate, they use sustainable (renewable and refuse) energy and generate nega-energy. This paper covers three research examples of this type of sustainability: (1) use of air-to-earth heat exchangers, (2) computer control of heating and cooling of the building (via heat pumps and heat-recovery devices), and (3) design control of energy consumption in a house. (author)

  9. Development of induction current acquisition device based on ARM

    Science.gov (United States)

    Ji, Yanju; Liu, Xiyang; Huang, Wanyu; Yao, Jiang; Yuan, Guiyang; Hui, Luan; Guan, Shanshan

    2018-03-01

    We design an induction current acquisition device based on ARM in order to realize high resolution and high sampling rate of acquisition for the induction current in wire-loop. Considering its characteristics of fast attenuation and small signal amplitude, we use the method of multi-path fusion for noise suppression. In the paper, the design is carried out from three aspects of analog circuit and device selection, independent power supply structure and the electromagnetic interference suppression of high frequency. DMA and ping-pong buffer, as a new data transmission technology, solves real time storage problem of massive data. The performance parameters of ARM acquisition device are tested. The comparison test of ARM acquisition device and cRIO acquisition device is performed at different time constants. The results show that it has 120dB dynamic range, 47kHz bandwidth, 96kHz sampling rate, 5μV the smallest resolution, and its average error value is not more than 4%, which proves the high accuracy and stability of the device.

  10. Evaluation, engineering and development of advanced cyclone processes. Final separating media evaluation and test report (FSMER)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-05-19

    {open_quotes}Evaluation Engineering and Development of Advanced Cyclone Processes{close_quotes} is one of the DOE-PETC sponsored advanced coal cleaning projects, which share a number of specific goals. These goals are to produce a 6% ash product, reject 85% of the parent coal`s pyritic sulfur, recover 85% of the parent coal`s Btu value, and provide products that are less than 30% moisture. The process in this project, as the name implies, relies on a cyclone or cyclonic separator to achieve physical beneficiation based on the gravimetric differences between clean coal and its impurities. Just as important as the cyclonic separator, if not more so, is the selection of a parting liquid or medium for use in the separator. Selection of a separating medium is regarded as a significant portion of the project because it has a profound impact on the required unit operations, the performance of the separator, and economics of the process. The choice of medium especially influences selection of media recovery system(s), and the characteristics of clean coal and refuse products. Since medium selection is such an important aspect of the project, portions of the project are dedicated to the study, evaluation, and selection of the most desirable medium. Though separators are an important component, this project initially focused on media study, rather than the separators themselves. In coal processing, discussion of media requires description of the handling and recovery system(s), separation performance, interaction with coal, cost, and health, environmental and safety issues. In order to be effective, a candidate must perform well in all of these categories.

  11. Recent developments in membrane-based separations in biotechnology processes: review.

    Science.gov (United States)

    Rathore, A S; Shirke, A

    2011-01-01

    Membrane-based separations are the most ubiquitous unit operations in biotech processes. There are several key reasons for this. First, they can be used with a large variety of applications including clarification, concentration, buffer exchange, purification, and sterilization. Second, they are available in a variety of formats, such as depth filtration, ultrafiltration, diafiltration, nanofiltration, reverse osmosis, and microfiltration. Third, they are simple to operate and are generally robust toward normal variations in feed material and operating parameters. Fourth, membrane-based separations typically require lower capital cost when compared to other processing options. As a result of these advantages, a typical biotech process has anywhere from 10 to 20 membrane-based separation steps. In this article we review the major developments that have occurred on this topic with a focus on developments in the last 5 years.

  12. Separation Anxiety in Parents of Adolescents: Theoretical Significance and Scale Development.

    Science.gov (United States)

    Hock, Ellen; Eberly, Mary; Bartle-Haring, Suzanne; Ellwanger, Pamela; Widaman, Keith F.

    2001-01-01

    Developed and validated Parents of Adolescents Separation Anxiety Scale with parents of sixth, eighth, tenth, and twelfth graders, and college freshmen and seniors. Factor analyses supported two subscales: Anxiety about Adolescent Distancing (AAD) and Comfort with Secure Base Role (CSBR); both showed distinctive change patterns with child age.…

  13. Separations and Waste Forms Research and Development FY 2013 Accomplishments Report

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2013-12-01

    The Separations and Waste Form Campaign (SWFC) under the U.S. Department of Energy (DOE) Fuel Cycle Research and Development Program (FCRD) is responsible for developing advanced separation and waste form technologies to support the various fuel cycle options defined in the DOE Nuclear Energy Research and Development Roadmap, Report to Congress, April 2010. The fiscal year (FY) 2013 accomplishments report provides a highlight of the results of the research and development (R&D) efforts performed within SWFC in FY 2013. Each section contains a high-level overview of the activities, results, technical point of contact, applicable references, and documents produced during the fiscal year. This report briefly outlines campaign management and integration activities, but the intent of the report is to highlight the many technical accomplishments made during FY 2013.

  14. Development of radiochemical separation method for determination of toxic elements in biological samples

    International Nuclear Information System (INIS)

    Maihara, V.A.; Vasconcellos, M.B.A.; Favaro, D.I.T.; Armelin, M.J.A.

    1990-01-01

    In order to determine Hg, Sb, As and Se in biological materials by neutron activation analysis, a radiochemical separation was developed. The chemical separation procedure used was based on the digestion of the irradiated sample in a mixture of H NO 3 and H 2 SO 4 in a teflon bomb, at 130 0 C for 1 to 4 hours. After the dissolution of organic matter, Hg and Sb were retained by a Dowex 2-X8 resin column in 6 M HCl. The effluent was passed through a TDO, tin dioxide column which retains As and Se in 3 M HCl medium. Radioactive tracers of these elements were used to determine the yields of the separation process. Certified reference materials were analyzed to check the precision and accuracy of the method. (author)

  15. Development of a radiochemical separation method for toxic elements determination from biologic samples

    International Nuclear Information System (INIS)

    Malhara, V.A.; Vasconcellos, M.B.A.; Favaro, D.I.T.; Armelin, M.J.A.

    1990-01-01

    In order to determine Hg, Sb, As and Se in biological materials by neutron activation analysis, a radiochemical separation was developed. The chemical separation procedure used was based on the digestion of the irradiated sample in a mixture of HNO 3 and H 2 SO 4 in a teflon bomb, at 130 0 C for 1 to 4 hours. After the dissolution of organic matter, Hg and Sb were retained by a Dowex 2-XB resin column in 6M HCI. The efluent was passed through a TDO, tin dioxide column which retains As and Se in 3M HCI medium. Radioactive tracers of these elements were used to determine the yields of the separation process. Certified reference materials were analyzed to check the precision and accuracy of the method. (author)

  16. Development of a Process for Separation of Mogroside V from Siraitia grosvenorii by Macroporous Resins

    Directory of Open Access Journals (Sweden)

    Ping Hu

    2011-08-01

    Full Text Available A separation method was developed for the preparative separation and enrichment of the non-caloric sweetener mogroside V from Siraitia grosvenorii. The adsorption properties of six macroporous resins were evaluated. Results showed that HZ 806 resin offered the best adsorption and desorption capacities. Based on the adsorption experiments on HZ 806, the adsorption data were found to fit the Freundlich model well. The pseudo-second-order kinetic model showed the highest correlation with the experimental results. Separation was performed with deionized water and 40% aqueous ethanol solution as mobile phases. In a typical run, 100 g of herb was processed and 3.38 g of mogroside V with a purity of 10.7% was harvested. This separation method provided a 15.1-fold increase in the purification factor from 0.5% to 10.7%. The present study showed that HZ 806 resins were effective for the separation and enrichment of mogroside V from S. grosvenorii.

  17. Development and Testing of an Americium/Lanthanide Separation Flowsheet Using Sodium Bismuthate

    Energy Technology Data Exchange (ETDEWEB)

    Jack Law; Bruce Mincher; Troy Garn; Mitchell Greenhalgh; Nicholas Schmitt; Veronica Rutledge

    2014-04-01

    The separation of Am from the lanthanides and curium is a key step in proposed advanced fuel cycle scenarios. The partitioning and transmutation of Am is desirable to minimize the long-term heat load of material interred in a future high-level waste repository. A separation process amenable to process scale-up remains elusive. Given only subtle chemistry differences within and between the ions of the trivalent actinide and lanthanide series this separation is challenging ; however, higher oxidation states of americium can be prepared using sodium bismuthate and separated via solvent extraction using diamylamylphosphonate (DAAP) extraction. Among the other trivalent metals only Ce is also oxidized and extracted. Due to the long-term instability of Am(VI) , the loaded organic phase is readily selectively stripped to partition the actinide to a new acidic aqueous phase. Batch extraction distribution ratio measurements were used to design a flowsheet to accomplish this separation. Additionally, crossflow filtration was investigated as a method to filter the bismuthate solids from the feed solution prior to extraction. Results of the filtration studies, flowsheet development work and flowsheet performance testing using a centrifugal contactor are detailed.

  18. CT and MRI slice separation evaluation by LabView developed software.

    Science.gov (United States)

    Acri, Giuseppe; Testagrossa, Barbara; Sestito, Angela; Bonanno, Lilla; Vermiglio, Giuseppe

    2018-02-01

    The efficient use of Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) equipment necessitates establishing adequate quality-control (QC) procedures. In particular, the accuracy of slice separation, during multislices acquisition, requires scan exploration of phantoms containing test objects. To simplify such procedures, a novel phantom and a computerised LabView-based procedure have been devised, enabling determination the midpoint of full width at half maximum (FWHM) in real time while the distance from the profile midpoint of two progressive images is evaluated and measured. The results were compared with those obtained by processing the same phantom images with commercial software. To validate the proposed methodology the Fisher test was conducted on the resulting data sets. In all cases, there was no statistically significant variation between the commercial procedure and the LabView one, which can be used on any CT and MRI diagnostic devices. Copyright © 2017. Published by Elsevier GmbH.

  19. Development of natural rubber membranes for separation of methyl tert-butyl ether and methanol

    International Nuclear Information System (INIS)

    Nur Azrini Ramlee; Ghazali Mohd Nawawi; Khairul Zaman Dahlan

    2010-01-01

    As a new commercial process, membrane separation raises significant expectations in the process plant of the future and therefore this research was being initiated to develop and characterize pervaporation membrane based on natural rubber (NR). Natural Rubber SMR-L grade which was supplied by Malaysia Rubber Research Institute (MRRI) was used for the development of the membranes via interpenetrating polymer network (IPN) techniques. Polystyrene (PS) was used to modify the natural rubber to further improve their mechanical and chemical properties. The membranes were prepared with various blend ratios of natural rubber, polystyrene and divinyl benzene as cross linker with constant 1 % of dicumyl peroxide as the initiator. The developed membranes were then characterized to study the functional group presence, membranes morphology, crosslink density, tear strength, adsorption of the membranes and pervaporation separation of Methyl-Tert-Butyl-Ether (MTBE) and Methanol. Pervaporation process was conducted by using varies of MTBE concentration 10, 30, 50 and 70 wt % and at differ operation temperature, 25 degree Celsius and 55 degree Celsius. Separation performance of IPN NR/ PS membranes were based on the presented permeation flux and separation factor. Examination through Fourier Transform Infrared Spectroscopy (FTIR), determined crosslink density and tear strength, 6 series of IPN NR/ PS membranes were successfully developed using natural rubber. Observation from Scanning Electron Microscopy (SEM) showed that the membranes were dense and appropriated for the pervaporation process application. From the pervaporation of MTBE and Methanol, IPN NR/ PS membranes of series D4N30 shown low permeation flux of MTBE but high separation factor while D2N70 membranes was vice versa for both temperature of 25 degree Celsius and 55 degree Celsius. (author)

  20. Development of a flat membrane based device for electromembrane extraction

    DEFF Research Database (Denmark)

    Huang, Chuixiu; Eibak, Lars Erik Eng; Gjelstad, Astrid

    2014-01-01

    this EME device, exhaustive extraction of the basic drugs quetiapine, citalopram, amitriptyline, methadone and sertraline was investigated from both acidified water samples and human plasma. The volume of acceptor solution, extraction time, and extraction voltage were found to be important factors...

  1. Development of a Modular Research Platform to Create Medical Observational Studies for Mobile Devices.

    Science.gov (United States)

    Zens, Martin; Grotejohann, Birgit; Tassoni, Adrian; Duttenhoefer, Fabian; Südkamp, Norbert P; Niemeyer, Philipp

    2017-05-23

    Observational studies have proven to be a valuable resource in medical research, especially when performed on a large scale. Recently, mobile device-based observational studies have been discovered by an increasing number of researchers as a promising new source of information. However, the development and deployment of app-based studies is not trivial and requires profound programming skills. The aim of this project was to develop a modular online research platform that allows researchers to create medical studies for mobile devices without extensive programming skills. The platform approach for a modular research platform consists of three major components. A Web-based platform forms the researchers' main workplace. This platform communicates via a shared database with a platform independent mobile app. Furthermore, a separate Web-based login platform for physicians and other health care professionals is outlined and completes the concept. A prototype of the research platform has been developed and is currently in beta testing. Simple questionnaire studies can be created within minutes and published for testing purposes. Screenshots of an example study are provided, and the general working principle is displayed. In this project, we have created a basis for a novel research platform. The necessity and implications of a modular approach were displayed and an outline for future development given. International researchers are invited and encouraged to participate in this ongoing project. ©Martin Zens, Birgit Grotejohann, Adrian Tassoni, Fabian Duttenhoefer, Norbert P Südkamp, Philipp Niemeyer. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 23.05.2017.

  2. Aerodynamic Analyses and Database Development for Ares I Vehicle First Stage Separation

    Science.gov (United States)

    Pamadi, Bandu N.; Pei, Jing; Pinier, Jeremy T.; Holland, Scott D.; Covell, Peter F.; Klopfer, Goetz, H.

    2012-01-01

    This paper presents the aerodynamic analysis and database development for the first stage separation of the Ares I A106 Crew Launch Vehicle configuration. Separate databases were created for the first stage and upper stage. Each database consists of three components: isolated or free-stream coefficients, power-off proximity increments, and power-on proximity increments. The power-on database consists of three parts, all plumes firing at nominal conditions, the one booster deceleration motor out condition, and the one ullage settling motor out condition. The isolated and power-off incremental databases were developed using wind tunnel test data. The power-on proximity increments were developed using CFD solutions.

  3. Design and development of a device management platform for EAST cryogenic system

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Zhiwei, E-mail: zzw@ipp.ac.cn; Lu, Xiaofei, E-mail: xiaofeilu@ipp.ac.cn; Zhuang, Ming, E-mail: zhm@ipp.ac.cn; Hu, Liangbing, E-mail: huliangbing@ipp.ac.cn; Xia, Genhai, E-mail: xgh@ipp.ac.cn

    2014-05-15

    Highlights: • A device management platform for EAST cryogenic system based on DCS is designed. • This platform enhances the integrity and continuity of system device information. • It can help predictive maintenance and device management decision. - Abstract: EAST cryogenic system is one of the critical sub-systems of the EAST tokamak device. It is a large scale helium cryoplant, which adopts distributed control system to realize monitoring and control of the cryogenic process and devices. However, the maintenance and management of most field devices are still in the corrective maintenance or traditional preventive maintenance stage. Under maintained or over maintained problems widely exist, which could cause devices fault and increase operation costs. Therefore, a device management platform is proposed for a safe and steady operation as well as fault diagnosis and predictive maintenance of EAST cryogenic system. This paper presents the function design and architecture design of the cryogenic device management platform. This platform is developed based on DeltaV DCS and acquires monitoring data through OPC protocol. It consists of three pillars, namely device information management, device condition management, and device performance monitoring. The development and implementation of every pillar are illustrated in detail in this paper. Test results and discussions are presented in the end.

  4. In-depth study of in-trap high-resolution mass separation by transversal ion ejection from a multi-reflection time-of-flight device.

    Science.gov (United States)

    Fischer, Paul; Knauer, Stefan; Marx, Gerrit; Schweikhard, Lutz

    2018-01-01

    The recently introduced method of ion separation by transversal ejection of unwanted species in electrostatic ion-beam traps and multi-reflection time-of-flight devices has been further studied in detail. As this separation is performed during the ion storage itself, there is no need for additional external devices such as ion gates or traps for either pre- or postselection of the ions of interest. The ejection of unwanted contaminant ions is performed by appropriate pulses of the potentials of deflector electrodes. These segmented ring electrodes are located off-center in the trap, i.e., between one of the two ion mirrors and the central drift tube, which also serves as a potential lift for capturing incoming ions and axially ejecting ions of interest after their selection. The various parameters affecting the selection effectivity and resolving power are illustrated with tin-cluster measurements, where isotopologue ion species provide mass differences down to a single atomic mass unit at ion masses of several hundred. Symmetric deflection voltages of only 10 V were found sufficient for the transversal ejection of ion species with as few as three deflection pulses. The duty cycle, i.e., the pulse duration with respect to the period of ion revolution, has been varied, resulting in resolving powers of up to several tens of thousands for this selection technique.

  5. Progress of research and development of nuclear fusion and development of large nuclear fusion device technology

    International Nuclear Information System (INIS)

    1994-01-01

    In the last several years, the results of tokamak experiments were conspicuous, and the progress of plasma confinement performance, transport mechanism, divertors and impurities, helium transport and exhaust, electric current drive, magnetic field ripple effect and high speed particle transport and DT experiment are reported. The other confinement methods than tokamak, the related theories and reactor technology are described. The conceptual design of ITER was carried out by the cooperation of Japan, USA, EC and the former USSR. The projects of developing nuclear fusion in various countries, the design and the required research and development of ITER, the reconstruction and the required research and development of JT-60, JET and TFTR, the design and the required research and development of large helical device, the state of research and development of laser nuclear fusion and inversion magnetic field pinch nuclear fusion, the activities and roles of industrial circles in large nuclear fusion device technology, and the long term perspective of the technical development of nuclear fusion are described. (K.I.)

  6. Copper Antimony Chalcogenide Thin Film PV Device Development

    Energy Technology Data Exchange (ETDEWEB)

    Welch, Adam W.; Baranowski, Lauryn L.; de Souza Lucas, Francisco Willian; Toberer, Eric S.; Wolden, Colin A.; Zakutayev, Andriy

    2015-06-14

    Emerging ternary chalcogenide thin film solar cell technologies, such as CuSbS2 and CuSbSe2, have recently attracted attention as simpler alternatives to quaternary Cu2ZnSnS4 (CZTS). Despite suitable photovoltaic properties, the initial energy conversion efficiency of CuSbS2 is rather low (0.3%). Here, we report on our progress towards improving the efficiency of CuSbS2 solar cells using a high throughput approach. The combinatorial methodology quickly results in baseline solar cell prototypes with 0.6% efficiency, and then modification of the back contact architecture leads to 1% PV devices. We then translate the optimal CuSbS2 synthesis parameters to CuSbSe2 devices, which show 3% efficiencies.

  7. Development of a magnetic measurement device for thin ribbon samples

    International Nuclear Information System (INIS)

    Sato, Yuta; Todaka, Takashi; Enokizono, Masato

    2008-01-01

    This paper presents a magnetic measurement device for thin ribbon samples, which are produced by rapid cooling technique. This device enables us to measure magnetic properties easily by only inserting a ribbon sample into a sample holder. The sample holder was made by bakelite to fix any width sample. A long solenoid coil was used to generate a uniform magnetic field and the sample holder was placed at the mid part of the solenoid. The magnetic field strength was measured using a shunt resistor and the magnetic flux density and magnetization in sample ribbons were evaluated by using search coils. The accuracy of measurement was verified with an amorphous metal ribbon sample. Next, we have measured magnetic properties of some magnetic shape memory alloys, which have different compositions. The measured results are compared and we clarified the effect of Sm contents on the magnetic properties

  8. The development of an enhanced strain measurement device to support testing of radioactive material packages

    International Nuclear Information System (INIS)

    Uncapkher, W.L.; Arviso, M.

    1995-01-01

    Radioactive material package designers use structural testing to verify and demonstrate package performance. A major part of evaluating structural response is the collection of reliable instrumentation measurement data. Over the last four decades, Sandia National Laboratories (SNL) has been actively involved in the development, testing, and evaluation of measurement devices for a broad range of applications, resulting in the commercialization of several measurement devices commonly used today. SNL maintains an ongoing program sponsored by the US Department of Energy (DOE) to develop and evaluate measurement devices to support testing of packages used to transport radioactive or hazardous materials. The development of the enhanced strain measurement device is part of this program

  9. Development of Hand Grip Assistive Device Control System for Old People through Electromyography (EMG) Signal Acquisitions

    OpenAIRE

    Khamis Herman; Mohamaddan Shahrol; Komeda Takashi; Alias Aidil Azli; Tanjong Shirley Jonathan; Julai Norhuzaimin; Hashim Nurul ‘Izzati

    2017-01-01

    The hand grip assistive device is a glove to assist old people who suffer from hand weakness in their daily life activities. The device earlier control system only use simple on and off switch. This required old people to use both hand to activate the device. The new control system of the hand grip assistive device was developed to allow single hand operation for old people. New control system take advantages of electromyography (EMG) and flex sensor which was implemented to the device. It wa...

  10. Feature Selection and Classifier Development for Radio Frequency Device Identification

    Science.gov (United States)

    2015-12-01

    248 Table C-5: p-values vs Test Statistic for Wine Quality. ................................................. 248 Table C-6...p-values vs Test Statistic for Wisconsin Breast Cancer. .............................. 249 Table C-7: p-values vs Test Statistic for Wine ...electronic devices, such as RF-DNA. A brief review of the various approaches is considered to illustrate the benefits of the RF-DNA approach. 40

  11. Prenatal parental separation and body weight, including development of overweight and obesity later in childhood.

    Directory of Open Access Journals (Sweden)

    Lena Hohwü

    Full Text Available Early parental separation may be a stress factor causing a long-term alteration in the hypothalamic-pituitary-adrenal-axis activity possibly impacting on the susceptibility to develop overweight and obesity in offspring. We aimed to examine the body mass index (BMI and the risk of overweight and obesity in children whose parents lived separately before the child was born.A follow-up study was conducted using data from the Aarhus Birth Cohort in Denmark and included 2876 children with measurements of height and weight at 9-11-years-of-age, and self-reported information on parental cohabitation status at child birth and at 9-11-years-of-age. Quantile regression was used to estimate the difference in median BMI between children whose parents lived separately (n = 124 or together (n = 2752 before the birth. We used multiple logistic regression to calculate odds ratio (OR for overweight and obesity, adjusted for gender, parity, breast feeding status, and maternal pre-pregnancy BMI, weight gain during pregnancy, age and educational level at child birth; with and without possible intermediate factors birth weight and maternal smoking during pregnancy. Due to a limited number of obese children, OR for obesity was adjusted for the a priori confounder maternal pre-pregnancy BMI only.The difference in median BMI was 0.54 kg/m2 (95% confidence intervals (CI: 0.10; 0.98 between children whose parents lived separately before birth and children whose parents lived together. The risk of overweight and obesity was statistically significantly increased in children whose parents lived separately before the birth of the child; OR 2.29 (95% CI: 1.18; 4.45 and OR 2.81 (95% CI: 1.05; 7.51, respectively. Additional, adjustment for possible intermediate factors did not substantially change the estimates.Parental separation before child birth was associated with higher BMI, and increased risk of overweight and obesity in 9-11-year-old children; this may suggest a fetal

  12. The current situation and development of medical device testing institutes in China.

    Science.gov (United States)

    Yang, Xiaofang; Mu, Ruihong; Fan, Yubo; Wang, Chunren; Li, Deyu

    2017-04-01

    This article analyses the current situation and development of Chinese medical device testing institutes from the perspectives of the two most important functions - testing functions and medical device standardization functions. Areas Covered: The objective of the Chinese government regulations for medical device industry is to ensure the safety and effectiveness of medical devices for Chinese patients. To support the regulation system, the Chinese government has established medical device testing institutes at different levels for example, the national, provincial, and municipal levels. These testing institutes also play an important role in technical support during medical device premarket registration and post market surveillance, they are also the vital practitioners of Chinese medical device standardization. Expert Commentary: Chinese medical device testing institutes are technical departments established by government, and serve the regulatory functions of government agency. In recent years, with the rapid development of medical device industry as well as constantly increasing international and domestic medical device market, the importance of medical device testing institute is more prominent, However, there are still some problems unsolved, such as their overall capacity remains to be improved, construction of standardization is to be strengthened, etc.

  13. Development of Separation Process for Minor Actinides Using TDdDGA and New Extractants

    International Nuclear Information System (INIS)

    Matsumura, T.; Tsubata, Y.

    2015-01-01

    Full text of publication follows: Separation process for minor actinides (MA = Am, Cm and Np) has been developed at Japan Atomic Energy Agency using new innovative extractants to improve the partitioning process from the viewpoints of the economy and the reduction of secondary wastes. Phosphorus-free compounds consisting of carbon, hydrogen, oxygen and nitrogen (CHON principle) were applied to the separation steps for MA. At the first step, MA and lanthanide elements (Ln) are recovered from high-level liquid waste by solvent extraction with N,N,N',N'-tetra-dodecyl-diglycolamide (TDdDGA). Trivalent actinides Am and Cm, are separated from RE at the next step by solvent extraction using podand type soft-donor extractant such as N,N,N',N'- tetrakis(pyridin-2-ylmethyl)- decane-1,2-diamine (TPDN) or hybrid type extractant such as N-octyl-N-(ptolyl)- 1,10-phenanthroline-2-carboxamide (OctTolPTA). This paper presents the current status of the research and development programme. This study is carried out under the Innovative Nuclear Research and Development Programme by the Ministry of Education, Culture, Sports, Science and Technology of Japan. (authors)

  14. THE SEPARATION BETWEEN ACCOUNTING PROFESSION AND TAX PROFESSION IN THE CONTEXT OF SUSTAINABLE DEVELOPMENT IN ROMANIA

    Directory of Open Access Journals (Sweden)

    MIHAELA-NICOLETA BĂCANU

    2016-06-01

    Full Text Available The relation between accounting and taxation is a complex issue. The development of this relation is still in progress in Romania. The purpose of this paper is to analyze the evolution of the accounting and tax profession in Romania for the last twenty-five years and to establish the moment of the separation between the two professions and the impact of this separation on the application of the accounting and taxation treatments, in the context of the sustainable development. This evolution is important to the three dimensions of sustainable development. In this paper it will be taken into consideration a theoretical and qualitative research using as methodology the analysis of the social documents: the regulations regarding the profession of chartered accountant and the profession of tax advisory. The starting point in this research is the fall of the communism when Romania is in research of a new identity. There can be identified three major stages of evolution: between 1990-2000 when the accountant was really important for accounting and fiscal issues, between 2001-2006 when the accountant professionals and tax professionals had different activities and after 2007 when there appeared the Chamber of Tax Consultants and the two professions have been separated through two professional bodies.

  15. NREL- and Sandia-Developed HyStEP Device Receives Far West FLC Award | News

    Science.gov (United States)

    | NREL NREL- and Sandia-Developed HyStEP Device Receives Far West FLC Award NREL- and Sandia -Developed HyStEP Device Receives Far West FLC Award September 1, 2016 The National Renewable Energy technologies and boost the regional economy. As FLC awards are granted for outstanding achievements in

  16. Development of a Math Input Interface with Flick Operation for Mobile Devices

    Science.gov (United States)

    Nakamura, Yasuyuki; Nakahara, Takahiro

    2016-01-01

    Developing online test environments for e-learning for mobile devices will be useful to increase drill practice opportunities. In order to provide a drill practice environment for calculus using an online math test system, such as STACK, we develop a flickable math input interface that can be easily used on mobile devices. The number of taps…

  17. An Energy-Saving Concept of the Smart Building Power Grid with Separated Lines for Standby Devices

    Directory of Open Access Journals (Sweden)

    Dmytro Zubov

    2016-09-01

    Full Text Available Standby power takes 5-10 % of the residential electricity around the world. Some countries lose more than 14 % of the total electricity used in the residential sector. Hence, a new energysaving concept that could help to decrease the power losses is discussed in this paper. Firstly, the two power lines of infrastructure for continuously connected equipment and for standby devices is proposed for new smart buildings. Secondly, the segmented infrastructure with unified hardwareunits is proposed for existing smart buildings (the new one can apply this principle as well. The contactors (i.e. unified hardware units consist of the NodeMcu Lua ESP8266 WiFi IoTdevelopment board, ACS712T ELC-30A current sensor, and the Songle relay. The automatic mode is based on three steps: measurement of the current using ACS712T ELC-30A sensor in all segments except the root; switching off the relays with the current less than or equal to any number in the historical data; switching off the root contactor if all the descendent relays (i.e. contactors are switched off. Second step represents the linear classification with sliding window in machine learning. The software consists of two parts, low-level Arduino sketches and high-level C# Windows form app. They are connected by MQTT broker Mosquitto. The proposed concept was successfully tested using a prototype with three segments, one of which includes smart lighting. The payback period is of approximately one month and a half for the whole-building switch concept.

  18. Development of grazing incidence devices for space-borne time of flight mass spectrometry

    Science.gov (United States)

    Cadu, A.; Devoto, P.; Louarn, P.; Sauvaud, J.-A.

    2012-04-01

    Time of flight mass spectrometer is widely used to study space plasmas in planetary and solar missions. This space-borne instrument selects ions in function of their energy through an electrostatic analyzer. Particles are then post-accelerated to energies in the range of 20 keV to cross a carbon foil. At the foil exit, electrons are emitted and separated from ion beam in the time of flight section. A first detector (a Micro-Channel Plate or MCP) emits a start signal at electron arrival and a second one emits a stop signal at incident ion end of path. The time difference gives the speed of the particle and its mass can be calculated, knowing its initial energy. However, current instruments suffer from strong limitations. The post acceleration needs very high voltage power supplies which are heavy, have a high power consumption and imply technical constraints for the development. A typical instrument weighs from 5 to 6 kg, includes a 20 kV power supply, consumes a least 5 W and encounters corona effect and electrical breakdown problems. Moreover, despite the particle high energy range, scattering and straggling phenomena in the carbon foil significantly reduce the instrument overall resolution. Some methods, such as electrostatic focus lenses or reflectrons, really improve mass separation but global system efficiency remains very low because of the charge state dependence of such devices. The main purpose of our work is to replace carbon foil by grazing incidence MCP's - also known as MPO's, for Micro Pore Optics - for electron emission. Thus, incident particles would back-scatter onto the channel inner surface with an angle of a few degrees. With this solution, we can decrease dispersion sources and lower the power supplies to post accelerate ions. The result would be a lighter and simpler instrument with a substantial resolution improvement. We have first simulated MPO's behavior with TRIM and MARLOWE Monte-Carlo codes. Energy scattering and output angle computed

  19. A prototype for communitising technology: Development of a smart salt water desalination device

    Science.gov (United States)

    Fakharuddin, F. M.; Fatchurrohman, N.; Puteh, S.; Puteri, H. M. A. R.

    2018-04-01

    Desalination is defined as the process that removes minerals from saline water or commonly known as salt water. Seawater desalination is becoming an attractive source of drinking water in coastal states as the costs for desalination declines. The purpose of this study is to develop a small scale desalination device and able to do an analysis of the process flow by using suitable sensors. Thermal technology was used to aid the desalination process. A graphical user interface (GUI) for the interface was made to enable the real time data analysis of the desalination device. ArduinoTM microcontroller was used in this device in order to develop an automatic device.

  20. Progesterone-releasing devices for cattle estrus induction and synchronization: Device optimization to anticipate shorter treatment durations and new device developments.

    Science.gov (United States)

    de Graaff, W; Grimard, B

    2018-05-01

    Synchronization programs using progesterone-releasing intravaginal devices that allow for fixed time artificial insemination are still finding increasing application in bovine reproduction. This practice is useful for rationalizing livestock management because an increased number of cows can be inseminated in one session without the need for estrus detection. Although much of the innovation related to the design and development of intravaginal devices for use in cattle took place in the previous century, progress in understanding the physiology of the bovine estrous cycle resulted in shorter treatment durations, a trend which is still continuing. In this competitive market, with little functional differentiation between the existing devices, the shorter treatment duration prompted for optimization of the progesterone content in the device, as the cost of the drug significantly contributes to the price per unit. For CIDR ® a reduction of the progesterone content of about 30 per cent was realized. Price reduction remained an important target for further device development. Next to reduction of progesterone content, cheaper and easier to process materials like polyethylene vinyl acetate (EVA) copolymers have been explored to replace the commonly used silicone elastomers. The reengineering effort of CIDR ® demonstrated that knowledge of release kinetics and insight into gradual depletion patterns in the device is critical for optimization of drug content without compromising performance (blood levels). More recent publications related to the use of alternative polymers like EVA and polyisoprene (IP) indicated encouraging results regarding further reduction of progesterone content. The use of EVA seems most promising, because it is in principle a low-cost polymer available in many grades and this thermoplastic polymer can be processed easily by means of commonly used techniques like injection molding and extrusion. The use of thermoplastic polymers, however, requires

  1. HIDRA: A new device for PFC and PMI development

    Science.gov (United States)

    Andruczyk, Daniel; Ruzic, David N.; Allain, Jean Paul; Curreli, Davide; HIDRA Team

    2014-10-01

    A toroidal plasma device is being constructed at the University of Illinois dedicated in part as a toroidal liquid-metal PFC technology test bench. The Hybrid Illinois stellarator/tokamak Device for Research and Applications (HIDRA) is a medium sized classical stellarator (previously WEGA, IPP Greifswald) with, R = 0.72 m, a = 0.19 m, B < 0.5 T and will be able to reach Te = 10-50 eV, ne = 1017--1018 m-3 with plasmas running up to several minutes. A critical knowledge gap for liquid-metal PFCs is their integration and performance in asymmetric confinement fusion environments. HIDRA will be used to evaluate technologies such as TEMHD driven flows for the first wall, help address key questions including whether a full toroidal liquid-metal loop can operate in a toroidal machine, test low recycling regimes and whether D can be removed and recycled easily. Also, UIUC's experience with in-situ diagnostics will open up new opportunities for innovative Material Application Testing (HIDRA-MAT).

  2. Development of analytical methods for the separation of plutonium, americium, curium and neptunium from environmental samples

    Energy Technology Data Exchange (ETDEWEB)

    Salminen, S.

    2009-07-01

    In this work, separation methods have been developed for the analysis of anthropogenic transuranium elements plutonium, americium, curium and neptunium from environmental samples contaminated by global nuclear weapons testing and the Chernobyl accident. The analytical methods utilized in this study are based on extraction chromatography. Highly varying atmospheric plutonium isotope concentrations and activity ratios were found at both Kurchatov (Kazakhstan), near the former Semipalatinsk test site, and Sodankylae (Finland). The origin of plutonium is almost impossible to identify at Kurchatov, since hundreds of nuclear tests were performed at the Semipalatinsk test site. In Sodankylae, plutonium in the surface air originated from nuclear weapons testing, conducted mostly by USSR and USA before the sampling year 1963. The variation in americium, curium and neptunium concentrations was great as well in peat samples collected in southern and central Finland in 1986 immediately after the Chernobyl accident. The main source of transuranium contamination in peats was from global nuclear test fallout, although there are wide regional differences in the fraction of Chernobyl-originated activity (of the total activity) for americium, curium and neptunium. The separation methods developed in this study yielded good chemical recovery for the elements investigated and adequately pure fractions for radiometric activity determination. The extraction chromatographic methods were faster compared to older methods based on ion exchange chromatography. In addition, extraction chromatography is a more environmentally friendly separation method than ion exchange, because less acidic waste solutions are produced during the analytical procedures. (orig.)

  3. Development of methodology for separation and recovery of uranium from nuclear wastewater

    International Nuclear Information System (INIS)

    Satpati, S.K.; Roy, S.B.; Pal, Sangita; Tewari, P.K.

    2015-01-01

    Uranium plays a key role in nuclear power supply, demand of which is growing up with time because of its prospective features. Persistent increase in different nuclear activities leads to increase generation of nuclear wastewater containing uranium. Separation and recovery of the uranium from its unconventional source like nuclear wastewater is worth to explore for addressing the reutilisation of the uranium source. It is also necessary to improve remediation technology of nuclear industries for environmental protection. Development of a suitable process methodology is essential for the purpose to supersede the conventional methodology. In the article, recent developments in several possible methodologies for separation of uranium from dilute solution have been discussed with their merits and demerits. Sorption technique as solid phase extraction methodology has been chosen with suitable polymer matrix and functional moiety based on wastewater characteristics. Polyhydroxamic Acid, PHOA sorbent synthesized following eco-friendly procedure is a promising polymeric chelating sorbents for remediation of nuclear wastewaters and recovery of uranium. Sorption and elution characteristics of the PHOA have been evaluated and illustrated for separation and recovery of uranium from a sample nuclear wastewater. For the remediation of nuclear wastewater SPE technique applying the PHOA, a polymeric sorbent is found to be a potentially suitable methodology. (author)

  4. Development of Electrically Switched Ion Exchange Process for Selective Ion Separations

    International Nuclear Information System (INIS)

    Rassat, Scot D.; Sukamto, Johanes H.; Orth, Rick J.; Lilga, Michael A.; Hallen, Richard T.

    1999-01-01

    The electrically switched ion exchange (ESIX) process, being developed at Pacific Northwest National Laboratory, provides an alternative separation method to selectively remove ions from process and waste streams. In the ESIX process, in which an electroactive ion exchange film is deposited onto a high surface area electrode, uptake and elution are controlled directly by modulating the electrochemical potential of the film. This paper addresses engineering issues necessary to fully develop ESIX for specific industrial alkali cation separation challenges. The cycling and chemical stability and alkali cation selectivity of nickel hexacyanoferrate (NiHCF) electroactive films were investigated. The selectivity of NiHCF was determined using cyclic voltammetry and a quartz crystal microbalance to quantify ion uptake in the film. Separation factors indicated a high selectivity for cesium and a moderate selectivity for potassium in high sodium content solutions. A NiHCF film with improved redox cycling and chemical stability in a simulated pulp mill process stream, a targeted application for ESIX, was also prepared and tested

  5. Xafs studies on actinide-pyridine-diamide complexes for development of an innovative separation process

    International Nuclear Information System (INIS)

    Hideaki, Shiwaku; Tsuyoshi, Yaita; Tohru, Kobayashi; Masahiko, Numakura; Tsuyoshi, Yaita; Shinichi, Suzuki; Yoshihiro, Okamoto

    2007-01-01

    We have been studying the bond properties and the structures of actinide (An) and lanthanide (Ln) complexes in detail using several kinds of X-ray analyses by synchrotron radiation in order to elucidate the ionic recognition mechanism of organic ligands. Generally, an oxygen donor type ligand separates both An and Ln from solutions of spent fuel or high level radioactive waste. Separation ability of this type of ligand for An and Ln follows the order of the surface charge density of an ion, i.e., An 4+ > AnO 2 2+ > An 3+ = Ln 3+ > AnO 2+ and/or a few structural factors. Therefore, this type of ligand is ineffective for the separation of An 3+ and Ln 3+ due to their similar chemical properties. Recently, new extractants like aromatic N-donor ligands have been developed using the preference of soft-donors to achieve the An 3+ /Ln 3+ separation. However, aromatic N-donor ligands often show a few problems such as protonation. In this developing process, we synthesized a new type of ligand, N,N'-dimethyl-N,N'-diphenyl-pyridine-2,6-carboxy-amide (DMDPh-PDA). The PDA is hybrid type ligand having oxygen and nitrogen as donor atoms and follows a unique separation order, i.e., An 4+ > An 3+ > AnO 2 2+ > Ln 3+ > AnO 2 + , probably arising from the combined effects of covalent bonding and steric hindrance. Hence, clarification of any ionic recognition mechanism of the PDA is very interesting from the view point of structural analysis. In this presentation, we will show XAFS results of An and Ln complexes with PDA in solution and discuss separation mechanism of An and Ln by PDA. Various kinds of complexes between Ln/An and PDA were prepared for XAFS analysis. The Ln complexes were measured in transmission mode at the K absorption edge on the BL11XU at SPring-8. On the other hand, the U complexes were measured in fluorescence mode at the L III absorption edge on the BL-27B at Photon Factory, High-energy Accelerator Research Organization (KEK). (authors)

  6. Development of a low-energy radioactive ion beam facility for the MARA separator

    Energy Technology Data Exchange (ETDEWEB)

    Papadakis, Philippos, E-mail: philippos.papadakis@jyu.fi; Moore, Iain; Pohjalainen, Ilkka; Sarén, Jan; Uusitalo, Juha [University of Jyväskylä, Department of Physics (Finland)

    2016-12-15

    A low-energy radioactive ion beam facility for the production and study of nuclei produced close to the proton drip line is under development at the Accelerator Laboratory of the University of Jyväskylä, Finland. The facility will take advantage of the mass selectivity of the recently commissioned MARA vacuum-mode mass separator. The ions selected by MARA will be stopped and thermalised in a small-volume gas cell prior to extraction and further mass separation. The gas cell design allows for resonance laser ionisation/spectroscopy both in-gas-cell and in-gas-jet. The facility will include experimental setups allowing ion counting, mass measurement and decay spectroscopy.

  7. The development of MEMS device packaging technology using proton beam

    International Nuclear Information System (INIS)

    Hyeon, J. W.; Kong, Y. J.; Kim, E. H.; Kim, H. S.; No, S. J.

    2006-05-01

    Wafer-bonding techniques are key issues for the commercialization of MEMS(MicroElectroMechanical Systems) devices. The anodic bonding method and the wafer direct-bonding method are well-known major techniques for wafer bonding. Due to the anodic bonding method includes high voltage processes above 1.5 kV, the MEMS devices can be damaged during the bonding process or malfunctioned while long-term operation. On the other hand, since the wafer direct-bonding method includes a high temperature processes above 1000 .deg. C, temperature-sensitive materials and integrated circuits will be damaged or degraded during the bonding processes. Therefore, high-temperature bonding processes are not applicable for fabricating or packaging devices where temperature-sensitive materials exist. During the past few years, much effort has been undertaken to find a reliable bonding process that can be conducted at a low temperature. Unfortunately, these new bonding processes depend highly on the bonding material, surface treatment and surface flatness. In this research, a new packaging method using proton beam irradiation is proposed. While the energy loss caused in an irradiated material by X-rays or electron beams decreases with the surface distance, the energy loss caused by proton beams has a maximum value at the Bragg peak. Thus, the localized energy produced at the Bragg peak of the proton beams can be used to bond pyrex glass on a silicon wafer, so the MEMS damage is expected to be minimized. The localized heating caused by as well as the penetration depth, or the proton beam has been investigated. The energy absorbed in a stack of pyrex glass/silicon wafers due to proton-beam irradiation was numerically calculated for various proton energies by using the SRIM program. The energy loss was shown to be sufficiently localized at the interface between the pyrex glass and the silicon wafer. Proton beam irradiation was performed in the common environment of room temperature and

  8. Role of thermo-physical properties on design and development of thermal plasma devices

    International Nuclear Information System (INIS)

    Ghorui, S.

    2014-01-01

    Thermal plasma devices find wide application in variety of technological areas like cutting, welding, spray coating, waste management, material processing, chemical reduction, nano-synthesis, novel material synthesis etc. Highly non-linear behavior of the plasma properties coupled with inherent instabilities, extremely high temperature, high gradients in thermal, and flow field, presence of thermal and chemical non-equilibrium make design and development of the plasma generating devices a challenging task as power levels of the devices increase

  9. Development of bacterially resistant polyurethane for coating medical devices

    International Nuclear Information System (INIS)

    Roohpour, Nima; Moshaverinia, Alireza; Wasikiewicz, Jaroslaw M; Paul, Deepen; Vadgama, Pankaj; Wilks, Mark; Millar, Michael

    2012-01-01

    Polyurethanes have been widely used in medicine for coating and packaging implantable and other medical devices. Polyether-urethanes, in particular, have superior mechanical properties and are biocompatible, but in common with other medical materials they are susceptible to microbial film formation. In this study, polyether-urethane was end-capped with silver lactate and silver sulfadiazine functional groups to produce a bacterially resistant polymer without sacrificing the useful mechanical properties of the polyether-polyurethane. The silver ions were covalently incorporated into the polymer during chain extension of the prepolymer. The functionalized polymers were structurally characterized by light scattering, electron microscopy, NMR, FTIR and Raman spectroscopy. Mechanical properties, hydrophilicity, in vitro stability and antibacterial action of polymers were also investigated. Results indicate that both silver salts were successfully incorporated into the polymer structure without significant effect on mechanical properties, whilst conferring acceptable bacterial resistance.

  10. Development of a Contingency Capillary Wastewater Management Device

    Science.gov (United States)

    Thomas, Evan A.

    2010-01-01

    The Personal Body .Attached Liquid Liquidator (PBALL) is conceived as a passive, capillary driven contingency wastewater disposal device. In this contingency scenario, the airflow system on the NASA Crew Exploration Vehicle (CEV) is assumed to have failed, leaving only passive hardware and vacuum vent to dispose of the wastewater. To meet these needs, the PBALL was conceived to rely on capillary action and urine wetting design considerations. The PBALL is designed to accommodate a range of wetting conditions, from 0deg < (theta)adv approx. 90deg, be adaptable for both male and female use, collect and retain up to a liter of urine, minimize splash-back, and allow continuous drain of the wastewater to vacuum while minimizing cabin air loss. A sub-scale PBALL test article was demonstrated on NASA's reduced gravity aircraft in April, 2010.

  11. Improving Device Efficiencies in Organic Photovoltaics through the Manipulation of Device Architectures and the Development of Low-Bandgap Materials

    Science.gov (United States)

    Rice, Andrew Hideo

    mixed separately; exposure to the nanowire during self-assembly may allow the fullerene to coat nanowire surfaces and influence the photocurrent within the device. Furthermore, because we are able to carefully control the regioregularity of our P3HT, we are able to produce a series of nanowires with regioregularities ranging between 93% and 99%. X-ray diffraction (XRD) shows that as the regioregularity of the polymer increases, the coherent domain size along the long-axis of the nanowires also becomes larger. When organic field effect transistors (OFETs) are made from these materials, the hole mobility of the nanowire films also has a positive correlation with regioregularity. As the domains within the nanowires grow larger, the frequency of domain boundaries decreases, allowing charges to percolate more efficiently along the nanowire. Additionally, we show that by introducing C60 into the active layer of P3HT:PCBM devices, we can modulate the crystal habit of the PCBM domains. Using optical microscopy and UV-vis absorption spectroscopy, we demonstrate that C60 additions alter the crystal morphology and greatly reduce the size of fullerene crystallites that are observed after extended annealing times and under aggressive aging conditions. We also show by fabricating organic field-effect transistors (OFETs) from PCBM:C60 blends that the incorporation of C60 does not adversely affect the electron mobility in these films. Finally, we show that as C60 is incorporated into P3HT:PCBM OPVs, devices become more thermally stable and do not degrade in performance as rapidly as traditional P3HT:PCBM blends. Lastly, the synthesis of four alternating copolymers using benzo[2,1- b;3,4-b']dithiophene (BDP) as the common donor unit is presented. Incorporating BDP, which consists of fused dithiophene units with a benzene ring, into these polymers should produce a low-lying highest occupied molecular orbital (HOMO) energy level. Low-lying HOMO levels are desirable to produce high open

  12. Isotopic separation

    International Nuclear Information System (INIS)

    Chen, C.L.

    1979-01-01

    Isotopic species in an isotopic mixture including a first species having a first isotope and a second species having a second isotope are separated by selectively exciting the first species in preference to the second species and then reacting the selectively excited first species with an additional preselected radiation, an electron or another chemical species so as to form a product having a mass different from the original species and separating the product from the balance of the mixture in a centrifugal separating device such as centrifuge or aerodynamic nozzle. In the centrifuge the isotopic mixture is passed into a rotor where it is irradiated through a window. Heavier and lighter components can be withdrawn. The irradiated mixture experiences a large centrifugal force and is separated in a deflection area into lighter and heavier components. (UK)

  13. An Advanced TALSPEAK Concept for Separating Minor Actinides. Part 1. Process Optimization and Flowsheet Development

    Energy Technology Data Exchange (ETDEWEB)

    Lumetta, Gregg J. [Pacific Northwest National Laboratory, Nuclear Science and Engineering Group, Richland, WA, USA; Levitskaia, Tatiana G. [Pacific Northwest National Laboratory, Nuclear Science and Engineering Group, Richland, WA, USA; Wilden, Andreas [Forschungszentrum Jülich GmbH, Institut für Energie- und Klimaforschung – Nukleare Entsorgung und Reaktorsicherheit (IEK-6), Jülich, Germany; Casella, Amanda J. [Pacific Northwest National Laboratory, Nuclear Science and Engineering Group, Richland, WA, USA; Hall, Gabriel B. [Pacific Northwest National Laboratory, Nuclear Science and Engineering Group, Richland, WA, USA; Lin, Leigh [Pacific Northwest National Laboratory, Nuclear Science and Engineering Group, Richland, WA, USA; Sinkov, Sergey I. [Pacific Northwest National Laboratory, Nuclear Science and Engineering Group, Richland, WA, USA; Law, Jack D. [Idaho National Laboratory, Aqueous Separations and Radiochemistry Department, Idaho Falls, ID, USA; Modolo, Giuseppe [Forschungszentrum Jülich GmbH, Institut für Energie- und Klimaforschung – Nukleare Entsorgung und Reaktorsicherheit (IEK-6), Jülich, Germany

    2017-08-18

    A system is being developed to separate trivalent actinides from lanthanide fission product elements that uses 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester to extract the lanthanide ions into an organic phase, while the actinide ions are held in the citrate-buffered aqueous phase by complexation to N-(2-hydroxyethyl)ethylenediamine-N,N',N'-triacetic acid (HEDTA). Earlier investigations of this system using a 2-cm centrifugal contactor revealed that the relatively slow extraction of Sm3+, Eu3+, and Gd3+ resulted in low separation factors from Am3+. In the work reported here, adjustments to the aqueous phase chemistry were made to improve the extraction rates. The results suggest that increasing the concentration of the citric acid buffer from 0.2 to 0.6 mol/L, and lowering the pH from 3.1 to 2.6, significantly improved lanthanide extraction rates resulting in an actinide/lanthanide separation system suitable for deployment in centrifugal contactors. Experiments performed to evaluate whether the lanthanide extraction rates can be improved by replacing aqueous HEDTA with nitrilotriacetic acid (NTA) exhibited promising results. However, NTA exhibited an unsatisfactorily high distribution value for Am3+ under the extraction conditions examined.

  14. Indigenous development and performance evaluation of BARC aerodynamic size separator (BASS)

    CERN Document Server

    Singh, S; Khan, A; Mayya, Y S; Narayanan, K P; Purwar, R C; Sapra, B K; Sunny, F

    2002-01-01

    Commercially available cascade impactors, commonly used for aerodynamic size separation of aerosol particles, are based on the principle of inertial impaction. As of now, these instruments are imported at a cost of several lakhs of rupees; hence an effort has been made to develop an aerodynamic particle sizer indigenously in BARC. This unit, referred to as BARC Aerodynamic Size Separator (BASS), separates aerosols into seven size classes ranging from 0.53 mu m to 10 mu m and operates at a flow rate of 45 Ipm. Intercomparison studies between the standard Andersen Mark-II (Grasbey Andersen Inc.) impactor and BASS using nebulizer generated aerosols have consistently shown excellent performance by BASS in all respects. In particular, BASS yielded the parameters of polydisperse aerosols quite accurately. Experiments to evaluate the individual stage cut-off diameters show that these are within 8% of their designed value for all stages except the higher two stages which indicate about 30% lower values than the desig...

  15. Development of Lectin-Linked Immunomagnetic Separation for the Detection of Hepatitis A Virus

    Science.gov (United States)

    Ko, Sang-Mu; Kwon, Joseph; Vaidya, Bipin; Choi, Jong Soon; Lee, Hee-Min; Oh, Myung-Joo; Bae, Hyeun-Jong; Cho, Se-Young; Oh, Kyung-Seo; Kim, Duwoon

    2014-01-01

    The accuracy and sensitivity of PCR-based methods for detection of hepatitis A virus (HAV) are dependent on the methods used to separate and concentrate the HAV from the infected cells. The pH and ionic strength affect the binding affinity of the virus to cells. In this study, we initially investigated the effects of pH (4.0–10.0) and metal ions (Fe2+, Co2+, Cu2+, Mg2+, K+, and Ca2+) on the binding of HAV to oyster digestive cells. The lowest relative binding (RB) of HAV to the cells was found at pH 4.0 and in FeSO4 solution (64.6% and 68.1%, respectively). To develop an alternative to antibody-dependent immunomagnetic separation prior to detection of HAV using RT-PCR, the binding of HAV to five lectins, peanut agglutinin (PNA), Dolichos biflorus agglutinin (DBA), Helix pomatia agglutinin (HPA), Ulex europaeus agglutinin (UEA-1) and soybean agglutinin (SBA), was evaluated using ELISAs. SBA showed significantly higher RB to HAV than the other lectins tested. In addition, HAV could be concentrated within 30 min using SBA-linked magnetic bead separation (SMS) prior to the RT-PCR assay. Our findings demonstrate the feasibility of using SMS combined with RT-PCR to detect HAV at dilutions ranging from 10−1–10−4 of a HAV stock (titer: 104 TCID50/mL). PMID:24599279

  16. Development of Lectin-Linked Immunomagnetic Separation for the Detection of Hepatitis A Virus

    Directory of Open Access Journals (Sweden)

    Sang-Mu Ko

    2014-03-01

    Full Text Available The accuracy and sensitivity of PCR-based methods for detection of hepatitis A virus (HAV are dependent on the methods used to separate and concentrate the HAV from the infected cells. The pH and ionic strength affect the binding affinity of the virus to cells. In this study, we initially investigated the effects of pH (4.0–10.0 and metal ions (Fe2+, Co2+, Cu2+, Mg2+, K+, and Ca2+ on the binding of HAV to oyster digestive cells. The lowest relative binding (RB of HAV to the cells was found at pH 4.0 and in FeSO4 solution (64.6% and 68.1%, respectively. To develop an alternative to antibody-dependent immunomagnetic separation prior to detection of HAV using RT-PCR, the binding of HAV to five lectins, peanut agglutinin (PNA, Dolichos biflorus agglutinin (DBA, Helix pomatia agglutinin (HPA, Ulex europaeus agglutinin (UEA-1 and soybean agglutinin (SBA, was evaluated using ELISAs. SBA showed significantly higher RB to HAV than the other lectins tested. In addition, HAV could be concentrated within 30 min using SBA-linked magnetic bead separation (SMS prior to the RT-PCR assay. Our findings demonstrate the feasibility of using SMS combined with RT-PCR to detect HAV at dilutions ranging from 10−1–10−4 of a HAV stock (titer: 104 TCID50/mL.

  17. Growth, characterization, and device development in monocrystalline diamond films

    Science.gov (United States)

    Davis, Robert F.

    1991-12-01

    The nucleation of diamond grains on an unscratched silicon wafer is enhanced by four order of magnitude relative to scratched substrates by using negative bias enhanced microwave plasma CVD in a 2 percent methane/hydrogen plasma for an initial period. In vacuo surface analysis has revealed that the actual nucleation occurs on the amorphous C coating present on the thin SiC layer which forms as the product of the initial reaction with the Si surface. It is believed that the C forms critical clusters which are favorable for diamond nucleation. Similar enhancement was observed together with the occurrence of textured diamond films in the use of bias pretreatment of cubic Beta SiC substrates. Approximately 50 percent of the initial diamond nuclei were aligned with the SiC substrate. In contrast, the use of the biasing pretreatment for one hour on polycrystalline substrates resulted in only about 7 percent coverage with diamond particles. Numerous techniques have been used to analyze the nucleation and growth phenomena, especially micro Raman and scanning tunneling microscopy. The latter technique has shown that the morphology of doped and undoped diamond nuclei are similar, as well as the fact that significant concentrations of vacancy related defects are present. In device related-studies, UV-photoemission studies have shown that TiC occurs at the Ti-diamond (100) interface after a 400 C anneal. The Schottky barrier height from this metal on p-type diamond was determined to be 1.0 eV. Indications of negative electron affinity (NEA) was observed and attributed to emission of electrons that are quasi-thermalized to the bottom of the conduction band. A disordered surface removes the NEA. The microwave performance of p-type (beta-doped) diamond MESFET's at 10 GHz has been further investigated. Elevated temperatures may be necessary to obtain sufficient free charge densities in the conducting channel but this will result in degraded device performance. Each of these

  18. The development and application of solid polymer electrolysis enrichment device of tritium in water

    International Nuclear Information System (INIS)

    Wen Xuelian; Yang Hailan Wu Bin; Yang Huaiyuan

    2003-01-01

    This paper briefly describes the working principle of solid polymer electrolysis enrichment device of tritium in water, presents experiments and works in development of SPE tritium automatic electrolysis enrichment device by CIRP, with which the water samples had been processed for TRIC2000, and the measurement results are satisfied

  19. Development of an ergonomics device for maintenance of hydraulic generators of Tucuruí hydropower plant.

    Science.gov (United States)

    Batista, I C; Gomes, G J C; Teles, C S; Oliveira, P F; Santos, R M; Sassi, A C; Sá, B; V, B; Pardauil, A A

    2012-01-01

    This paper aims to present an ergonomic device to assist in the maintenance of the units of Tucuruí Hydropower Plant. The development of this ergonomic device made possible to reduce maintenance time, reduce losses caused by billing, improve performance and reduce the physical strain for labors during the execution of services.

  20. Development of a Smart Release Algorithm for Mid-Air Separation of Parachute Test Articles

    Science.gov (United States)

    Moore, James W.

    2011-01-01

    The Crew Exploration Vehicle Parachute Assembly System (CPAS) project is currently developing an autonomous method to separate a capsule-shaped parachute test vehicle from an air-drop platform for use in the test program to develop and validate the parachute system for the Orion spacecraft. The CPAS project seeks to perform air-drop tests of an Orion-like boilerplate capsule. Delivery of the boilerplate capsule to the test condition has proven to be a critical and complicated task. In the current concept, the boilerplate vehicle is extracted from an aircraft on top of a Type V pallet and then separated from the pallet in mid-air. The attitude of the vehicles at separation is critical to avoiding re-contact and successfully deploying the boilerplate into a heatshield-down orientation. Neither the pallet nor the boilerplate has an active control system. However, the attitude of the mated vehicle as a function of time is somewhat predictable. CPAS engineers have designed an avionics system to monitor the attitude of the mated vehicle as it is extracted from the aircraft and command a release when the desired conditions are met. The algorithm includes contingency capabilities designed to release the test vehicle before undesirable orientations occur. The algorithm was verified with simulation and ground testing. The pre-flight development and testing is discussed and limitations of ground testing are noted. The CPAS project performed a series of three drop tests as a proof-of-concept of the release technique. These tests helped to refine the attitude instrumentation and software algorithm to be used on future tests. The drop tests are described in detail and the evolution of the release system with each test is described.

  1. Development of device producing electrolyzed water for home care

    International Nuclear Information System (INIS)

    Umimoto, K; Nagata, S; Yanagida, J

    2013-01-01

    When water containing ionic substances is electrolyzed, electrolyzed water with strong bactericidal ability due to the available chlorine(AC) is generated on the anode side. Slightly acidic to neutral electrolyzed water (pH 6.5 to 7.5) is physiological pH and is suitable for biological applications. For producing slightly acidic to neutral electrolyzed water simply, a vertical-type electrolytic tank with an asymmetric structure was made. As a result, a small amount of strongly alkaline water was generated in the upper cathodic small chamber, and a large amount of weakly acidic water generated in the lower anodic large chamber. The pH and AC concentration in solutin mixed with both electrolyzed water were 6.3 and 39.5 ppm, respectively, This solution was slightly acidic to neutral electrolyzed water and had strong bactericidal activity. This device is useful for producing slightly acidic to neutral electrolyzed water as a disinfectant to employ at home care, when considering economic and environmental factors, since it returns to ordinary water after use.

  2. Development of a three-microneedle device for hypodermic drug delivery and clinical application.

    Science.gov (United States)

    Fukamizu, Hidekazu; Fujiwara, Masao; Kim, Taishi; Matsushita, Yuki; Tokura, Yoshiki

    2012-08-01

    There is a potential use for intradermic or hypodermic drug delivery in skin surgery or aesthetic surgery. Hypodermic delivery with the use of a noninvasive device can be a more useful, reliable, and effective administration route to obtain higher compliance. The authors developed a microneedle device composed of three fine needles (three-microneedle device). The tip of each needle was fabricated with a bevel angle to release a drug broadly into the tissue in a horizontal fashion. In this study, the authors investigated the usefulness of this newly developed three-microneedle device for hypodermic liquid injection, focusing on the optimum insertion depth and the diffusion of injected materials to the tissue. The authors also assessed the efficacy of and patient satisfaction with three-microneedle device injections of botulinum toxin type A for wrinkle reduction in patients with glabellar rhytides. The three-microneedle device yielded consistent results in hypodermal diffusion. On India ink diffusion test and ultrasonographic imaging, three-microneedle device injection showed a broad diffusion in horizontal extension, as compared with usual 31-gauge needle injection. The efficiency and satisfaction of the patients receiving botulinum toxin type A with the three-microneedle device were highly rated. Three-microneedle device delivery enables accurate and broad diffusion of injected substances, thus reducing the total dose and/or injection number of drugs. Therapeutic, IV.

  3. Development of an Immunomagnetic Separation Method for Viable Salmonella Typhimurium Detected by Flow Cytometry

    DEFF Research Database (Denmark)

    Ahmed, Shakil; Rubahn, Horst-Günter; Erdmann, Helmut

    2016-01-01

    for detection of food-related bacteria. In this study, a flow cytometry based immunomagnetic separation (IMS) method for the isolation and enrichment of Salmonella Typhimurium from liquid samples was developed and optimized. Both polyclonal and monoclonal antibodies have been used to couple with 1 micron sized...... and bacteria, immunocapture time, staining and buffering conditions for the viability assays were optimized. The capture efficiency of IMS was>98% for a range of Salmonella Typhimurium cell concentrations from 103 to 105/mL using 108/mL bead concentration. The method proved to have high (98%) specificity...

  4. Development of Magnetic Nanomaterials and Devices for Biological Applications

    National Research Council Canada - National Science Library

    O'Connor, Charles J; Hormes, Josef; Bazan, Nicolas

    2007-01-01

    .... Novel bio-compatible ferrofluids of functionalized magnetic nanoparticles suitable for bioconjugation of antibodies or other active biomolecules are developed, prepared, and tested for use in bio...

  5. De novo development of eosinophilic myocarditis with left ventricular assist device support as bridge to transplant.

    Science.gov (United States)

    Pereira, Naveen L; Park, Soon J; Daly, Richard C; Kushwaha, Sudhir S; Edwards, William D

    2010-10-01

    The de novo development of myocarditis during left ventricular assist device support for dilated cardiomyopathy has not been previously described. We report a case of severe eosinophilic myocarditis associated with the use of leukotriene-receptor antagonist montelukast that developed during left ventricular assist device support accompanied by intra-device thrombus formation that was hemodynamically tolerated and subsequently discovered in the explanted heart. There may be no visible change in cardiac function as assessed by echocardiography, but the diagnosis should be entertained with the development of peripheral eosinophilia. Copyright © 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  6. Trend of Energy Saving in Electronic Devices for Research and Development

    Directory of Open Access Journals (Sweden)

    Rahmayanti R.

    2016-01-01

    Full Text Available In electronic industry, energy saving is one of the performance indicators of competitiveness beside price, speed, bandwidth and reliability. This affects research and development (R&D activity in mechatronic systems which uses electronic components and electronic systems. A review of trend of electronic devices technology development has been conducted with focus on energy saving. This review includes electronic devices, semiconductor, and nanotechnology. It can be concluded that the trend in electronic devices is mainly dictated by semiconductor technology development. The trend can be concluded as smaller size, lower voltage leading to energy saving, less heat, higher speed, more reliable, and cheaper. In accordance to such technology development, R&D activities in mechatronics especially in Indonesia is being pushed to make proper alignment.Some of such alignment actions are surface mount technology (SMT for installing surface mount devices components (SMD, design layout and SMD troubleshooting tools as well as human resources training and development.

  7. Integration of human factors and ergonomics during medical device design and development: it's all about communication.

    Science.gov (United States)

    Vincent, Christopher James; Li, Yunqiu; Blandford, Ann

    2014-05-01

    Manufacturers of interactive medical devices, such as infusion pumps, need to ensure that devices minimise the risk of unintended harm during use. However, development teams face challenges in incorporating Human Factors. The aim of the research reported here was to better understand the constraints under which medical device design and development take place. We report the results of a qualitative study based on 19 semi-structured interviews with professionals involved in the design, development and deployment of interactive medical devices. A thematic analysis was conducted. Multiple barriers to designing for safety and usability were identified. In particular, we identified barriers to communication both between the development organisation and the intended users and between different teams within the development organisation. We propose the use of mediating representations. Artefacts such as personas and scenarios, known to provide integration across multiple perspectives, are an essential component of designing for safety and usability. Copyright © 2013 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  8. Development of measuring device for inner surfaces of embedded piping (Contract research)

    Energy Technology Data Exchange (ETDEWEB)

    Itoh, Hirokuni [Ohyo Koken Kogyo Co., Ltd., Tokyo (Japan); Hatakeyama, Mutsuo [Radioactive Waste Management and Nuclear Facility Decommissioning Technology Center, Tokyo (Japan); Tachibana, Mitsuo; Yanagihara, Satoshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2003-03-01

    The measuring device for inner surfaces of embedded piping (MISE) was developed to evaluate low-level radiological contaminations of inner surfaces of piping. The MISE consists of a cylindrically-formed double layered type detector and a piping crawling robot, which were designed and manufactured separately. In measurements of the contaminations, an outer cylindrical detector close to the surface of piping measures {beta}-rays and {gamma}-rays and an inner cylindrical detector set after a shielding plate for shield of {beta}-rays measures {gamma}-rays. The {beta}-ray counting rates are derived by subtracting {gamma}-ray counts measured by the inner detector from {gamma}- and {beta}-ray counts measured by the outer detector. The piping crawling robot transports the cylindrically-formed double layered type detector with observing inner surfaces of piping. The detection limit for the contamination of {sup 60}Co was found to be about 0.17 Bq/cm{sup 2} with measurement time of 30 seconds. It is expected that 0.2 Bq/cm{sup 2} corresponding to clearance level of {sup 60}Co (0.4 Bq/g) can be evaluated with measurement time of 2 seconds, which is equal to measurement speed of 54 m/h. (author)

  9. Development of measuring device for inner surfaces of embedded piping (Contract research)

    CERN Document Server

    Itoh, H; Tachibana, M; Yanagihara, S

    2003-01-01

    The measuring device for inner surfaces of embedded piping (MISE) was developed to evaluate low-level radiological contaminations of inner surfaces of piping. The MISE consists of a cylindrically-formed double layered type detector and a piping crawling robot, which were designed and manufactured separately. In measurements of the contaminations, an outer cylindrical detector close to the surface of piping measures beta-rays and gamma-rays and an inner cylindrical detector set after a shielding plate for shield of beta-rays measures gamma-rays. The beta-ray counting rates are derived by subtracting gamma-ray counts measured by the inner detector from gamma- and beta-ray counts measured by the outer detector. The piping crawling robot transports the cylindrically-formed double layered type detector with observing inner surfaces of piping. The detection limit for the contamination of sup 6 sup 0 Co was found to be about 0.17 Bq/cm sup 2 with measurement time of 30 seconds. It is expected that 0.2 Bq/cm sup 2 co...

  10. Diagnostics Development towards Steady State Operation in Fusion Devices

    Energy Technology Data Exchange (ETDEWEB)

    Burhenn, R.; Baldzuhn, J.; Dreier, H.; Endler, M.; Hartfuss, H.J.; Hildebrandt, D.; Hirsch, M.; Koenig, R.; Kornejev, P.; Krychowiak, M.; Laqua, H.P.; Laux, M.; Oosterbeek, J.W.; Pasch, E.; Schneider, W.; Thomsen, H.; Weller, A.; Werner, A.; Wolf, R.; Zhang, D. [Max-Planck-Institute fuer Plasmaphysik, EURATOM Association, D-17491 Greifswald (Germany); Biel, W. [Institut fuer Energieforschung - Plasmaphysik, Forschungszentrum Juelich GmbH EURATOM Association, Trilateral Euregio Cluster, D-52425 Juelich (Germany)

    2011-07-01

    The stellarator Wendelstein 7-X (W7-X) is being presently under construction and is already equipped with superconducting coil systems and principally is capable of quasi-continuous operation. However, W7-X is faced with new enhanced technical requirements which have to be met by plasma facing components as well as the diagnostic systems in general. Depending on the available heating power, the continuous heat flux to plasma facing components during long pulse operation might lead to unacceptable local thermal overload and necessitates sufficient but often complicate active cooling precautions. Fusion devices with electron cyclotron frequency heating (ECRH) are concerned with significant stray radiation, depending on the chosen heating scheme and the plasma parameters. The required shielding is often not compatible with optimal UHV-consistent design and high intensity throughput. For machine safety, diagnostics are required which are able to identify enhanced plasma wall interaction on a fast time scale in order to prevent damage in time. For W7-X, video camera systems covering most of the inner wall, fast IR-camera systems with coating-resistant pinhole-optics for the observation of the divertor surface temperature and spectrometers with large spectral survey covering relevant spectral lines of all intrinsic impurities with sufficient spectral resolution and sensitivity are necessary. In combination with energy integrating but spatially resolving diagnostics like bolometers and soft-X cameras slow impurity accumulation phenomena on a time scale much larger than flat-top times typically achieved in short-pulse operation can be identified and a radiative plasma collapse possibly be avoided by counteractive measures. Longer port dimensions due to thermal insulation of the cryogenic coil system and high density operation with strong density gradients necessitate the choice of shorter wavelengths for interferometer laser beams. This complicates the avoidance of fringe

  11. Effects of maternal separation on the neurobehavioral development of newborn Wistar rats.

    Science.gov (United States)

    Farkas, Jozsef; Reglodi, Dora; Gaszner, Balazs; Szogyi, Donat; Horvath, Gabor; Lubics, Andrea; Tamas, Andrea; Frank, Falko; Besirevic, Dario; Kiss, Peter

    2009-05-29

    Animal models of neonatal stress, like maternal separation, may provide important correlation with human stress-related disorders. Early maternal deprivation has been shown to cause several short- and long-term neurochemical and behavioral deficits. Little is known about the early neurobehavioral development after postnatal stress. The aim of the present study was to investigate the development of reflexes and motor coordination in male and female pups subjected to maternal deprivation. Pups were removed from their mothers from postnatal day 1-14, for 3h daily. Somatic development (weight gain, eye opening, ear unfolding, incisor eruption) and reflex development was tested during the first 3 weeks. The appearance of the following reflexes was investigated: crossed extensor, grasping, placing, gait, righting and sensory reflexes, and negative geotaxis. Timely performance of negative geotaxis, righting and gait were also tested daily during the first 3 weeks. Motor coordination and open-field tests were performed on postnatal weeks 3-5 (rotarod, elevated grid-walk, footfault, rope suspension, inclined board and walk initiation tests). The results revealed that a 3-h-long daily maternal separation did not lead to a marked delay or enhancement in reflex development and motor coordination. A subtle enhancement was observed in the appearance of hindlimb grasp and gait reflexes, and a better performance in footfault test in male rats suffering from maternal deprivation. In contrast, female maternally deprived (MD) rats displayed a slight delay in forelimb grasp and air righting reflex appearance, and surface righting performance. Open-field activity was not changed in maternally deprived rats. In summary, our present observations indicate that maternal deprivation does not induce drastic changes in early neurodevelopment, therefore, further research is needed to determine the onset of behavioral alterations in subject with maternal deprivation history. Gender differences

  12. Development of a dry-mechanical graphite separation process and elimination of the separated carbon for the reprocessing of spherical HTR fuel elements

    International Nuclear Information System (INIS)

    Kronschnabel, H.

    1982-01-01

    Due to the C-14 distribution the separation of the particle-free outer region of the spherical HTR fuel element with subsequent solidification of the separated carbon makes it possible to reduce by half the remaining C-14 inventory in the inner particle region to be further treated. Separation of the particle-free outer region by a newly developed sphere-peeling milling machine, conditioning the graphite into compacts and in-situ cementation into a salt-mine are the basic elements of this head-end process variation. An annual cavern volume of approx. 2000 m 3 will be needed to ultimately store the graphite of the particle-free outer region, which corresponds to a reprocessing capacity of 50 GWsub(e) installed HTR power. The brush-disintegration of the remaining inner particle region and the resulting peel-brush-preparation are capable of separating 95% of the graphite without any heavy metal losses. With the mentioned reprocessing capacity an annual cavern volume of approx. 16.500 m 3 is required. (orig.) [de

  13. Development of a mini-mobile digital radiography system by using wireless smart devices.

    Science.gov (United States)

    Jeong, Chang-Won; Joo, Su-Chong; Ryu, Jong-Hyun; Lee, Jinseok; Kim, Kyong-Woo; Yoon, Kwon-Ha

    2014-08-01

    The current technologies that trend in digital radiology (DR) are toward systems using portable smart mobile as patient-centered care. We aimed to develop a mini-mobile DR system by using smart devices for wireless connection into medical information systems. We developed a mini-mobile DR system consisting of an X-ray source and a Complementary Metal-Oxide Semiconductor (CMOS) sensor based on a flat panel detector for small-field diagnostics in patients. It is used instead of the systems that are difficult to perform with a fixed traditional device. We also designed a method for embedded systems in the development of portable DR systems. The external interface used the fast and stable IEEE 802.11n wireless protocol, and we adapted the device for connections with Picture Archiving and Communication System (PACS) and smart devices. The smart device could display images on an external monitor other than the monitor in the DR system. The communication modules, main control board, and external interface supporting smart devices were implemented. Further, a smart viewer based on the external interface was developed to display image files on various smart devices. In addition, the advantage of operators is to reduce radiation dose when using remote smart devices. It is integrated with smart devices that can provide X-ray imaging services anywhere. With this technology, it can permit image observation on a smart device from a remote location by connecting to the external interface. We evaluated the response time of the mini-mobile DR system to compare to mobile PACS. The experimental results show that our system outperforms conventional mobile PACS in this regard.

  14. Research and development to protect soldiers from landmines and improvised explosive devices

    CSIR Research Space (South Africa)

    Ahmed, R

    2015-10-01

    Full Text Available Landmines and Improvised Explosive Devices (IEDs) remain a major threat for military vehicles, their occupants and other assets. It is thus imperative that traditional methods of protection need to be adapted or new technologies developed....

  15. Development and evaluation of measurement devices used to support testing of radioactive material transportation packages

    International Nuclear Information System (INIS)

    Uncapher, W.L.; Ammerman, D.J.; Stenberg, D.R.; Bronowski, D.R.; Arviso, M.

    1992-01-01

    Radioactive material package designers use structural testing to verify and demonstrate package performance. A major part of evaluating structural response is the collection of instrumentation measurement data. Sandia National Laboratories (SNL) has an ongoing program to develop and evaluate measurement devices to support testing of radioactive material packages. Measurement devices developed in support of this activity include evaluation channels, ruggedly constructed linear variable differential transformers, and piezoresistive accelerometers with enhanced measurement capabilities. In addition to developing measurement devices, a method has been derived to evaluate accelerometers and strain gages for measurement repeatability, ruggedness, and manufacturers' calibration data under both laboratory and field conditions. The developed measurement devices and evaluation technique will be discussed and the results of the evaluation will be presented

  16. Recent development of high gradient superconducting magnetic separator for kaolin in China

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Zian; Wang, Meifen; Ning, Fei Peng; Yang, Huan; Zhang, Guoqing; Hou, Zhi Long; Liu, Zhaong Xiu; Dai, Zhong [Institute of High Energy Physics and University of Chinese Academy of Sciences, Beijing (China); Li, Pei Yong; Zhang, Yiting; Wang, Zhaolian [Weifang Xinli Superconducting Technology Co.,Ltd., Weifang (China)

    2017-03-15

    A series of high gradient superconducting magnetic separator (HGMS) for kaolin has been developed. It is used for processing kaolin to increase the brightness or whiteness whether it is for paper or ceramic applications. The HGMS system mainly consists of a solenoid magnet with a zero boil-off helium cryostat, a double reciprocating canisters system, and a PLC (Process Logic Controller) fully automatic control system based on SCADA (Supervisory Control and Data Acquisition) system. We have successfully developed CGC-5.5/300 and CGC-5.0/500 HGMS systems in the recent years, and now three sets of them are on-site operation in different customers. This paper will present recent progress of the HGMS system, the results of some experiments on processing kaolin clay used HGMS, and the on-site operation.

  17. Recent development of high gradient superconducting magnetic separator for kaolin in China

    International Nuclear Information System (INIS)

    Zhu, Zian; Wang, Meifen; Ning, Fei Peng; Yang, Huan; Zhang, Guoqing; Hou, Zhi Long; Liu, Zhaong Xiu; Dai, Zhong; Li, Pei Yong; Zhang, Yiting; Wang, Zhaolian

    2017-01-01

    A series of high gradient superconducting magnetic separator (HGMS) for kaolin has been developed. It is used for processing kaolin to increase the brightness or whiteness whether it is for paper or ceramic applications. The HGMS system mainly consists of a solenoid magnet with a zero boil-off helium cryostat, a double reciprocating canisters system, and a PLC (Process Logic Controller) fully automatic control system based on SCADA (Supervisory Control and Data Acquisition) system. We have successfully developed CGC-5.5/300 and CGC-5.0/500 HGMS systems in the recent years, and now three sets of them are on-site operation in different customers. This paper will present recent progress of the HGMS system, the results of some experiments on processing kaolin clay used HGMS, and the on-site operation

  18. Agile application development for mobile devices. Case study: Mobile taximeter

    Directory of Open Access Journals (Sweden)

    Angélica María Babativa Goyeneche

    2016-10-01

    Full Text Available Context: Globalization has affected all productive sectors and in particular the software industry, which has required the development of new methodologies to suit the speed of the changes and allow quickly build products that meet the requirements of the customers. On the other hand, the GPS technology, 4G connectivity and integration of social networks that have the most current mobile phones have opened a large field of application, particularly in the area of the transport, mobility and citizen complaint, whose development can be successfully addressed through an agile methodology. Method: Agile methodology Scrum was used for the development of a mobile application on the Android operating system and GPS technology, which allows a Bogota taxi user to monitor the route and send a complaint to the social network Twitter in case of nonconformity. Some UML models were used for analysis and design of the application, and a confidence interval was used to validate the results. Results: Prototype of a mobile taximeter developed with an agile methodology that meets quality characteristics, extensibility and maintainability. T-student distribution was used to validate the measurement of the prototype on 50 samples, concluding that the difference between the measurement of a real taximeter and our mobile taximeter is on average 2 units with a standard deviation of 1,39 units. Conclusions: It is shown that with the agile development can be combined with UML modeling tools and statistical validation techniques for quality products that do not violate, but on the contrary, that reaffirm the agile development principles.

  19. Development and validation of a new guidance device for lateral approach stereotactic breast biopsy

    Energy Technology Data Exchange (ETDEWEB)

    Ma, K.; Kornecki, A.; Bax, J.; Mundt, Y.; Fenster, A. [Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6A 5K8 (Canada) and Biomedical Engineering Graduate Program, University of Western Ontario, London, Ontario N6A 5B9 (Canada); Department of Radiology, St. Joseph' s Health Care London, London, Ontario N6A 4V2 (Canada) and Department of Medical Imaging, The University of Western Ontario, London, Ontario N6A 5A5 (Canada); Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6A 5K8 (Canada) and Biomedical Engineering Graduate Program, University of Western Ontario, London, Ontario N6A 5B9 (Canada); Department of Radiology, St. Joseph' s Health Care London, London, Ontario N6A 4V2 (Canada) and Department of Diagnostic Radiology and Nuclear Medicine, University of Western Ontario, London, Ontario N6A 5A5 (Canada); Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6A 5K8 (Canada); Biomedical Engineering Graduate Program, University of Western Ontario, London, Ontario N6A 5B9 (Canada) and Department of Medical Imaging, University of Western Ontario, London, Ontario N6A 5A5 (Canada)

    2009-06-15

    Stereotactic breast biopsy (SBB) is the gold standard for minimally invasive breast cancer diagnosis. Current systems rely on one of two methods for needle insertion: A vertical approach (perpendicular to the breast compression plate) or a lateral approach (parallel to the compression plate). While the vertical approach is more frequently used, it is not feasible in patients with thin breasts (<3 cm thick after compression) or with superficial lesions. Further, existing SBB guidance hardware provides at most one degree of rotational freedom in the needle trajectory, and as such requires a separate skin incision for each biopsy target. The authors present a new design of lateral guidance device for SBB, which addresses the limitations of the vertical approach and provides improvements over the existing lateral guidance hardware. Specifically, the new device provides (1) an adjustable rigid needle support to minimize needle deflection within the breast and (2) an additional degree of rotational freedom in the needle trajectory, allowing the radiologist to sample multiple targets through a single skin incision. This device was compared to a commercial lateral guidance device in a series of phantom experiments. Needle placement error using each device was measured in agar phantoms for needle insertions at lateral depths of 2 and 5 cm. The biopsy success rate for each device was then estimated by performing biopsy procedures in commercial SBB phantoms. SBB performed with the new lateral guidance device provided reduced needle placement error relative to the commercial lateral guidance device (0.89{+-}0.22 vs 1.75{+-}0.35 mm for targets at 2 cm depth; 1.94{+-}0.20 vs 3.21{+-}0.31 mm for targets at 5 cm depth). The new lateral guidance device also provided improved biopsy accuracy in SBB procedures compared to the commercial lateral guidance device (100% vs 58% success rate). Finally, experiments were performed to demonstrate that the new device can accurately sample

  20. RackSaver neutron absorbing device development and testing

    International Nuclear Information System (INIS)

    Lambert, R.; O'Leary, P.; Roberts, P.

    1996-01-01

    Siemens Power Corporation (SPC), in cooperation with the Electric Power Research Institute (EPRI), has developed the RackSaver neutron absorbing insert. The RackSaver insert can be installed onto spent nuclear fuel assemblies to replace deteriorating Boraflex neutron absorbing material installed in some spent-fuel storage racks. This paper describes results of a development and in-pool demonstration program performed to support potential utilization of the RackSaver neutron absorbing insert by affected utilities. The program objective was to advance the RackSaver concept into a field-demonstrated product. This objective was accomplished through three phases: design, licensing and criticality evaluations, and demonstration testing

  1. Development of fluidic device in SIT for Korean Next Generation Reactor I

    International Nuclear Information System (INIS)

    Cho, Bong Hyun; Lee, Joon; Bae, Yoon Young; Park, Jong Kyun

    1999-07-01

    The KNGR is to install a Fluidic Device at the bottom of the inner space of the SIT (Safety Injection Tank) to control the flow rate of safety injection coolant from SIT during LBLOCA. During the past two years, a scale model test to obtain the required flow characteristics of the device under the KNGR specific conditions has been performed using the experience and existing facility of AEA Technology (UK) with appropriate modifications. The performance verification test is to be performed this year to obtain optimum characteristics and design data of full size fluidic device. The purpose of the model test was to check the feasibility of developing the device and to produce a generic flow characteristic data. The test was performed in approximately 1/7 scale in terms of flow rate with full height and pressure. This report presents the details of system performance requirements for the device, design procedure for the fluidic device to be used, test facility and test method. The time dependent flow, pressure and Euler number are presented as characteristics curves and the most stable and the most effective flow control characteristic parameters were recommended through the evaluation. A method to predict the size of the fluidic device is presented. And a sizing algorithm, which can be used to conveniently determine the major geometric data of the device for various operating conditions, and a FORTRAN program to produce the prediction of performance curves have been developed. (author). 32 refs., 15 tabs., 47 figs

  2. Development of standard technical report on using and selecting wireless device in nuclear power plants

    International Nuclear Information System (INIS)

    Koo, I. S.; Hong, S. B.; Cho, J. W.

    2011-11-01

    1. Purpose · Development of IEC technical report on wireless device using in nuclear power plants 2. Contents · IEC technical reports of draft for circulation and final draft for next planary meeting · Case study on experiment of wireless devices 3. Implementation methods · Preparation of first draft with experts group, its circulation, discussions on the results of the circulation · Organizing three teams such as preparation, reviews and experiment 4. Results · Maintenance cost will be reduced with application of the wireless technologies in nuclear power plants · Commercial wireless devices will be developed before standard is issued

  3. Development of a high speed extrusion concept using a floating screw sleeve for solid-melt-separation

    Science.gov (United States)

    Karrenberg, Gregor; Wortberg, Johannes

    2015-05-01

    The High-Speed-S-Truder with floating screw sleeve is an alternative extrusion concept with solid-melt-separation. A fairly conventional 35 mm screw with a length of 21 D, which is accelerated by a 75 kW gearless, water cooled synchronous drive, conveys the resin into a 60 mm screw sleeve with a length of 10 D. Inside the sleeve the material is plasticizied and discharged into the outer screw channel of the sleeve through radial bores. Only the solid bed remains inside. The development of a melt pool - and thus a decrease of the plasticizing capacity - is avoided. The sleeve is rotated by drag forces only (approximately 10 - 15 % of the screw speed). Due to the low speed of the screw sleeve molten material is conveyed to a 4 D Dynamic Mixing Ring in a gentle manner. The DMRs floating ring and the screw sleeve are directly coupled. The granules in the screw channel are stopped by a barrier on the screw in front of the mixing device. So nearly no unmelted material can pass the system. For temperature management in the plastification and mixing zone a 3-zone heating/air-cooling system is used. Various kinds of experiments with the High-Speed S-Truder were conducted. Reachable throughputs with different types of material (LDPE, LLDPE, PP, PS) have been tested. Also three screw geometries, which are mainly varying in the channel depth, were compared. Experimental results and theoretical background will be described in this paper.

  4. Development of a Device for Objective Assessment of Tinnitus in Humans

    Science.gov (United States)

    2017-10-01

    AWARD NUMBER: W81XWH-14-2-0180 TITLE: Development of a Device for Objective Assessment of Tinnitus in Humans PRINCIPAL INVESTIGATOR: Jeremy G...SUBTITLE Development of a Device for Objective Assessment of Tinnitus in Humans 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-14-2-0180 5c. PROGRAM...briefly (one paragraph) describes the subject, purpose and scope of the research. Tinnitus is the perception of sound in the ears or head when no

  5. Indigenous development and performance evaluation of BARC aerodynamic size separator (BASS)

    International Nuclear Information System (INIS)

    Singh, Sanjay; Purwar, R.C.; Das, Tanmoy; Narayanan, K.P.; Sapra, B.K.; Sunny, Faby; Khan, Arshad; Mayya, Y.S.

    2002-06-01

    Commercially available cascade impactors, commonly used for aerodynamic size separation of aerosol particles, are based on the principle of inertial impaction. As of now, these instruments are imported at a cost of several lakhs of rupees; hence an effort has been made to develop an aerodynamic particle sizer indigenously in BARC. This unit, referred to as BARC Aerodynamic Size Separator (BASS), separates aerosols into seven size classes ranging from 0.53 μm to 10 μm and operates at a flow rate of 45 Ipm. Intercomparison studies between the standard Andersen Mark-II (Grasbey Andersen Inc.) impactor and BASS using nebulizer generated aerosols have consistently shown excellent performance by BASS in all respects. In particular, BASS yielded the parameters of polydisperse aerosols quite accurately. Experiments to evaluate the individual stage cut-off diameters show that these are within 8% of their designed value for all stages except the higher two stages which indicate about 30% lower values than the designed ones. The replotting of all the mass distribution data using the experimental cut-off diameters showed perfect lognormal fits, thereby indicating that these diameters are closer to the true stage cut-off diameters for BASS. The studies show that BASS will be suitable for determining the particle size distributions in the context of the radiological safety programmes of DAE. Being indigenous in design, it may be fabricated on a commercial scale at a cost far less than that of the imported units. Such a venture will greatly help several national programmes on atmospheric pollution being carried out by many laboratories and institutions across the country. (author)

  6. Development and Optimization of a Flocculation Procedure for Improved Solid-Liquid Separation of Digested Biomass

    Energy Technology Data Exchange (ETDEWEB)

    Patton, Caroline; Lischeske, James J.; Sievers, David A.

    2015-11-03

    One viable treatment method for conversion of lignocellulosic biomass to biofuels begins with saccharification (thermochemical pretreatment and enzymatic hydrolysis), followed by fermentation or catalytic upgrading to fuels such as ethanol, butanol, or other hydrocarbons. The post-hydrolysis slurry is typically 4-8 percent insoluble solids, predominantly consisting of lignin. Suspended solids are known to inhibit fermentation as well as poison catalysts and obstruct flow in catalyst beds. Thus a solid-liquid separation following enzymatic hydrolysis would be highly favorable for process economics, however the material is not easily separated by filtration or gravimetric methods. Use of a polyacrylamide flocculant to bind the suspended particles in a corn stover hydrolyzate slurry into larger flocs (1-2mm diameter) has been found to be extremely helpful in improving separation. Recent and ongoing research on novel pretreatment methods yields hydrolyzate material with diverse characteristics. Therefore, we need a thorough understanding of rapid and successful flocculation design in order to quickly achieve process design goals. In this study potential indicators of flocculation performance were investigated in order to develop a rapid analysis method for flocculation procedure in the context of a novel hydrolyzate material. Flocculation conditions were optimized on flocculant type and loading, pH, and mixing time. Filtration flux of the hydrolyzate slurry was improved 170-fold using a cationic polyacrylamide flocculant with a dosing of approximately 22 mg flocculant/g insoluble solids at an approximate pH of 3. With cake washing, sugar recovery exceeded 90 percent with asymptotic yield at 15 L wash water/kg insoluble solids.

  7. Development of advanced materials and devices for nuclear radiation measurements

    International Nuclear Information System (INIS)

    Gadkari, S.C.

    2015-01-01

    Single crystals of technologically important materials are grown in the Crystal Technology Section of the Technical Physics Division, BARC. These crystals find applications as scintillators and dosimeters in nuclear radiation detection/measurements. Scintillator crystals of some advanced materials like cerium doped Gd 3 Ga 3 Al 2 O 12 , Lu 2 SiO 5 , YAIO 3 etc and some conventional materials such as Bi 4 Ge 3 O 12 , CsI:Tl, NaI:Tl, etc have been grown from melts using the Czochralski and Bridgman techniques. Portable gamma-ray spectrometers that work from a USB port of a laptop have been developed using the grown scintillator crystals. In recent years there has been a flurry of research activities on materials containing Li 6 , B 10 , etc that have large capture cross-sections for neutrons to develop solid state detectors for neutrons. For this purpose single crystals of cerium doped Li 6 Y(BO 3 ) 3 and silver doped Li 2 B 4 O 7 have been developed. Optical, thermo-luminescence, photo-luminescence and scintillation properties of these crystals have been investigated with a view to develop detectors and dosimeters. The Li 2 B 4 O 7 :Ag is a tissue equivalent material (Z eff = 7.3 close to 7.4 of tissue) useful in the personal and medical dosimetry applications. As the emission of Ag + lies in the UV region (267 nm), a customized TL measurement set-up has been developed using a solar blind PMT that enabled the measurement of very low doses below 5 μGy and linearity up to 100 Gy. Films of CsI:TI in the 10 nm to 3 μm thickness range were deposited on silicon substrates using the physical vapor deposition technique under vacuum conditions. The deposited films investigated using SEM and AFM revealed a columnar growth behavior with a preferential orientation along <200>. The growth of single crystals from melts, recent efforts in the development of detectors and results of experiments conducted to detect thermal neutrons are described. (author)

  8. Development of lead-bismuth coolant technology for nuclear device

    International Nuclear Information System (INIS)

    Kamata, Kin-ya; Kitano, Teruaki; Ono, Mikinori

    2004-01-01

    Liquid lead-bismuth is a promising material as a future fast reactor coolant or an intensive neutron source material for accelerator driven transmutation system (ADS). To develop nuclear plants and their installations using lead-bismuth coolant for practical use, both coolant technologies, inhabitation process of steels and quality control of coolant, and total operation system for liquid lead-bismuth plants are required. Based on the experience of liquid metal coolant, Mitsui Engineering and Shipbuilding Co., Ltd. (MES) has completed the liquid lead-bismuth forced circulation loop and has acquired various engineering data on main components including economizer. As a result of tis operation, MES has developed key technologies of lead-bismuth coolant such as controlling of oxygen content in lead-bismuth and a purification of lead-bismuth coolant. MES participated in the national project, ''The Development of Accelerator Driven Transmutation System'', together with JAERI (Japan Atomic Energy Research Institute) and started corrosion test for beam window of ADS. (author)

  9. Development of Hydrogen Separation Module with Structured Catalyst for Use in Membrane Reformer

    International Nuclear Information System (INIS)

    Isamu Yasuda; Tatsuya Tsuneki; Yoshinori Shirasaki; Toru Shimamori; Hidekazu Shigaki; Hiroyuki Tanaka

    2006-01-01

    A new type of hydrogen separation module for use in a membrane reformer was proposed and developed. The new module, what we call MOC (Membrane On Catalyst), was designed to have a membrane of palladium-based alloy prepared on the surface of the tubular structured catalyst that has catalytic activity for steam reforming reaction, thermal expansion matching with the membrane material, proper porosity, mechanical strength and thermal conductivity. The best composition of the structured catalyst was identified in the composites of metallic Ni and YSZ (Yttria-Stabilized Zirconia). A hydrogen separation module was manufactured by electroless plating of Pd with thickness of 7 to 15 microns on the surface of porous sintered tube of Ni-YSZ with an approximate size of 9 mm in diameter and 100 mm in length. The hydrogen permeability measurements have shown hydrogen flux of 25 to 35 cc/min at 550 to 600 C, which is higher than the permeability of the conventional modules using rolled Pd film. (authors)

  10. Pediatric medical device development by surgeons via capstone engineering design programs.

    Science.gov (United States)

    Sack, Bryan S; Elizondo, Rodolfo A; Huang, Gene O; Janzen, Nicolette; Espinoza, Jimmy; Sanz-Cortes, Magdalena; Dietrich, Jennifer E; Hakim, Julie; Richardson, Eric S; Oden, Maria; Hanks, John; Haridas, Balakrishna; Hury, James F; Koh, Chester J

    2018-03-01

    There is a need for pediatric medical devices that accommodate the unique physiology and anatomy of pediatric patients that is increasingly receiving more attention. However, there is limited literature on the programs within children's hospitals and academia that can support pediatric device development. We describe our experience with pediatric device design utilizing collaborations between a children's hospital and two engineering schools. Utilizing the academic year as a timeline, unmet pediatric device needs were identified by surgical faculty and matched with an engineering mentor and a team of students within the Capstone Engineering Design programs at two universities. The final prototypes were showcased at the end of the academic year and if appropriate, provisional patent applications were filed. All twelve teams successfully developed device prototypes, and five teams obtained provisional patents. The prototypes that obtained provisional patents included a non-operative ureteral stent removal system, an evacuation device for small kidney stone fragments, a mechanical leech, an anchoring system of the chorio-amniotic membranes during fetal surgery, and a fetal oxygenation monitor during fetoscopic procedures. Capstone Engineering Design programs in partnership with surgical faculty at children's hospitals can play an effective role in the prototype development of novel pediatric medical devices. N/A - No clinical subjects or human testing was performed. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Development of an automatized device for eddy current testing

    International Nuclear Information System (INIS)

    David, B.; Benoist, B.; Champonnois, F.; Viard, J.

    1990-01-01

    To improve performances in eddy current studies, several tools were developed in the Saclay Laboratory: - ELEFANT is a very flexible software which allows a rapid creation of new NDT applications, preserving anytime a full compatibility between computers, applications, data... used under the same ELEFANT controlkey. - Modulo'STA is a modular hardware designed to be the flexible interface between the probe and the computer, driving the measurement, the probe movement... - rotating EC probes with local rotation facilities allow the control of very long steam generator tubes, even bent [fr

  12. Design and Development of a Portable WiFi enabled BIA device

    International Nuclear Information System (INIS)

    Kriz'aj, D; Baloh, M; Zagar, T; Brajkovic, R

    2013-01-01

    A bioimpedance device (BIA) for evaluation of sarcopenia – age related muscle mass loss – is designed, developed and evaluated. The requirements were based on lightweight design, flexible and user enabled incorporation of measurement protocols and WiFi protocol for remote device control, full internet integration and fast development and usage of measurement protocols. The current design is based on usage of a microcontroller with integrated AD/DA converters. The prototype system was assembled and the operation and connectivity to different handheld devices and laptop computers was successfully tested. The designed BIA device can be accessed using TCP sockets and once the connection is established the data transfer runs successfully at the specified speed. The accuracy of currently developed prototype is about 5% for the impedance modulus and 5 deg. for the phase for the frequencies below 20 kHz with an unfiltered excitation signal and no additional amplifiers employed.

  13. Development of Ultrafiltration Membrane-Separation Technology for Energy-Efficient Water Treatment and Desalination Process

    Energy Technology Data Exchange (ETDEWEB)

    Yim, Woosoon [Univ. of Nevada, Las Vegas, NV (United States); Bae, Chulsung [Rensselaer Polytechnic Inst., Troy, NY (United States)

    2016-10-28

    The growing scarcity of fresh water is a major political and economic challenge in the 21st century. Compared to thermal-based distillation technique of water production, pressure driven membrane-based water purification process, such as ultrafiltration (UF), nanofiltration (NF) and reverse osmosis (RO), can offer more energy-efficient and environmentally friendly solution to clean water production. Potential applications also include removal of hazardous chemicals (i.e., arsenic, pesticides, organics) from water. Although those membrane-separation technologies have been used to produce drinking water from seawater (desalination) and non-traditional water (i.e., municipal wastewater and brackish groundwater) over the last decades, they still have problems in order to be applied in large-scale operations. Currently, a major huddle of membrane-based water purification technology for large-scale commercialization is membrane fouling and its resulting increases in pressure and energy cost of filtration process. Membrane cleaning methods, which can restore the membrane properties to some degree, usually cause irreversible damage to the membranes. Considering that electricity for creating of pressure constitutes a majority of cost (~50%) in membrane-based water purification process, the development of new nano-porous membranes that are more resistant to degradation and less subject to fouling is highly desired. Styrene-ethylene/butylene-styrene (SEBS) block copolymer is one of the best known block copolymers that induces well defined morphologies. Due to the polarity difference of aromatic styrene unit and saturated ethylene/butylene unit, these two polymer chains self-assemble each other and form different phase-separated morphologies depending on the ratios of two polymer chain lengths. Because the surface of SEBS is hydrophobic which easily causes fouling of membrane, incorporation of ionic group (e,g, sulfonate) to the polymer is necessary to reduces fouling

  14. The configuration development and integration of the TPX device

    International Nuclear Information System (INIS)

    Brown, T.G.

    1993-01-01

    The TPX configuration was designed to meet the physics objectives and subsystem requirements in an arrangement that allowed access for remote maintenance. The steady state operations of TPX favored the use of superconducting magnets for both the toroidal and poloidal field systems. The desire to react the TF centering and overturning forces in a simplified wedged system lead to a TF case concept incorporating ''two-coil'' TF modules in a 90 degrees four-coil quadrant arrangement. Low ripple and tangential plasma access to accommodate TFTR neutral beams were leading factors in determining the size and number of TF coils. The need for a large amount of space for the divertor and first wall component coolant services further influenced the shaping of the vacuum vessel. Additional configuration influences included: low activation considerations, diverter pumping, remote maintenance requirements, service access and compatibility with the existing TFTR text cell facility. The TPX configuration development and integration process has evolved through the conceptual design period and is now ready to enter the Preliminary Design Phase of the project. This paper describes the status of the configuration development and integration of the major TPX tokamak subsystems components

  15. Development of actively cooled divertor plates for fusion experimental devices

    Energy Technology Data Exchange (ETDEWEB)

    Onozuka, M. [Mitsubishi Heavy Industries Ltd., Yokohama (Japan); Toyoda, M. [Mitsubishi Heavy Industries Ltd., Yokohama (Japan); Tsujimura, S. [Mitsubishi Heavy Industries Ltd., Yokohama (Japan); Inoue, M. [Mitsubishi Heavy Industries Ltd., Yokohama (Japan); Satoh, M. [Mitsubishi Heavy Industries Ltd., Yokohama (Japan)

    1995-12-31

    Development of high thermal resistant divertor plates using the brazing technique has been conducted. Uni-directional carbon-fiber-reinforced-carbon (CFC) has been selected as the surface material because of its high thermal conductivity and mechanical strength, while copper-alloy has been chosen as the base plate because of its high thermal conductivity. Brazing materials on CFC were examined and applied to the divertor element samples (25mm x 25mm x 35mm). Then, the samples were exposed to a high heat flux electron beam. It was found that the fabricated samples can withstand repetitive thermal shocks of 30MW/m{sup 2} x 2sec for more than 500 times. Using the developed method, two types of partial divertor models were fabricated and tested. It was shown that the models have sufficient structural integrity against thermal shocks of 9MW/m{sup 2} x 3sec-14MW/m{sup 2} x 4sec for up to 1200 times. The thermal analyses suggested that the models could withstand the steady-state heat flux of 12.6MW/m{sup 2}. In addition, the thermal stress analyses showed that the structural modification could reduce the thermal stress on the models. (orig.).

  16. Development of a New X-Ray Polarization Detection Device

    Science.gov (United States)

    Thompson, Jahreem R.; Hill, Joanne E.; Jahoda, Keith; Black, Kevin; Querrard, Rodney

    2018-01-01

    The aim of this research is to confirm the functionality of a Gas Electron Multiplier made of stainless steel in a detection medium of carbon dioxide and nitromethane through a series of X-ray tests in a vacuum chamber. Utilizing the photoelectric effect with carbon dioxide and nitromethane, we can confirm polarization of X-rays emitted from the most extreme astronomical conditions. We chose to use CO2 because we can confirm that it works well with the stainless-steel detector based on previous tests and nitromethane because we suspect that the ionization electrons created by the photoelectron during the photoelectric effect will experience less diffusion if they are bonded to a large molecule such as nitromethane as they diffuse towards the drift plate. The development of these new X-ray polarimeters will help to further the study of gravitational fields near black holes, their effects on matter they encounter, and the magnetic fields of neutron stars.

  17. Developing and Testing SpaceWire Devices and Networks

    Science.gov (United States)

    Parkes, Steve; Mills, Stuart

    2014-08-01

    SpaceWire is a data-handling network for use on-board spacecraft, which connects together instruments, mass- memory, processors, downlink telemetry, and other on- board sub-systems [1]. SpaceWire is simple to implement and has some specific characteristics that help it support data-handling applications in space: high-speed, low-power, simplicity, relatively low implementation cost, and architectural flexibility making it ideal for many space missions. SpaceWire provides high-speed (2 Mbits/s to 200 Mbits/s), bi- directional, full-duplex data-links, which connect together SpaceWire enabled equipment. Data-handling networks can be built to suit particular applications using point-to-point data-links and routing switches.Since the SpaceWire standard was published in January 2003, it has been adopted by ESA, NASA, JAXA and RosCosmos for many missions and is being widely used on scientific, Earth observation, commercial and other spacecraft. High-profile missions using SpaceWire include: Gaia, ExoMars rover, Bepi- Colombo, James Webb Space Telescope, GOES-R, Lunar Reconnaissance Orbiter and Astro-H.The development and testing of the SpaceWire links and networks used on these and many other spacecraft currently under development, requires a comprehensive array of test equipment. In this paper the requirements for test equipment fulfilling key test functions are outlined and then equipment that meets these requirements is described. Finally the all-important software that operates with the test equipment is introduced.

  18. Development of a new universal machine device for eccentric shafts processing

    Directory of Open Access Journals (Sweden)

    Михайло Володимирович Маргуліс

    2015-11-01

    Full Text Available The analysis of the existing lathe devices for machining of eccentric details and the reasons for the development of a new universal machine device– a shifting lathe center-have been described in the article. The device design, its operating principle, the main parts functions and elements of the case were described and illustrated One of the most complicated cases of eccentric shaft turning, that is turning design and scheme of the eccentric shaft of precessional harmonic drive with intermediate rolling bodies when the proposed device was used was described in the article. The shifting lathe center can reduce the complexity of the machine tool for turning eccentric shafts configuration. The ability to install the shifting center in the tailstock and headstock of the lathe, and the availability of the leash makes it possible to turn various eccentric parts, conical surfaces, to apply the device to compensate for the emerging taper in cylindrical shafts processing. All the above mentioned makes the device universal. The specific feature of this device is the use of a ball center and the connection of the centering element with the adjusting screw by a fine thread screw, this increasing the precision machining. The protective cover of the device makes it possible to reduce the chance of possible injury from protruding parts of the device, namely the leash and the centering element

  19. Design, development, and evaluation of a novel retraction device for gallbladder extraction during laparoscopic cholecystectomy.

    Science.gov (United States)

    Judge, Joshua M; Stukenborg, George J; Johnston, William F; Guilford, William H; Slingluff, Craig L; Hallowell, Peter T

    2014-02-01

    A source of frustration during laparoscopic cholecystectomy involves extraction of the gallbladder through port sites smaller than the gallbladder itself. We describe the development and testing of a novel device for the safe, minimal enlargement of laparoscopic port sites to extract large, stone-filled gallbladders from the abdomen. The study device consists of a handle with a retraction tongue to shield the specimen and a guide for a scalpel to incise the fascia within the incision. Patients enrolled underwent laparoscopic cholecystectomy. Gallbladder extraction was attempted. If standard measures failed, the device was implemented. Extraction time and device utility scores were recorded for each patient. Patients returned 3-4 weeks postoperatively for assessment of pain level, cosmetic effect, and presence of infectious complications. Twenty (51 %) of 39 patients required the device. Average extraction time for the first eight patients was 120 s. After interim analysis, an improved device was used in 12 patients and average extraction time was 24 s. There were no adverse events. Postoperative pain ratings and incision cosmesis were comparable between patients with and without use of the device. The study device enables safe and rapid extraction of impacted gallbladders through the abdominal wall.

  20. Development of Hand Grip Assistive Device Control System for Old People through Electromyography (EMG Signal Acquisitions

    Directory of Open Access Journals (Sweden)

    Khamis Herman

    2017-01-01

    Full Text Available The hand grip assistive device is a glove to assist old people who suffer from hand weakness in their daily life activities. The device earlier control system only use simple on and off switch. This required old people to use both hand to activate the device. The new control system of the hand grip assistive device was developed to allow single hand operation for old people. New control system take advantages of electromyography (EMG and flex sensor which was implemented to the device. It was programmed into active and semi-active mode operation. EMG sensors were placed on the forearm to capture EMG signal of Flexor Digitorum Profundus muscle to activate the device. Flex sensor was used to indicate the finger position and placed on top of the finger. The signal from both sensors then used to control the device. The new control system allowed single hand operation and designed to prevent user from over depended on the device by activating it through moving their fingers.

  1. Separable roles of UFO during floral development revealed by conditional restoration of gene function.

    Science.gov (United States)

    Laufs, Patrick; Coen, Enrico; Kronenberger, Jocelyne; Traas, Jan; Doonan, John

    2003-02-01

    The UNUSUAL FLORAL ORGANS (UFO) gene is required for several aspects of floral development in Arabidopsis including specification of organ identity in the second and third whorls and the proper pattern of primordium initiation in the inner three whorls. UFO is expressed in a dynamic pattern during the early phases of flower development. Here we dissect the role of UFO by ubiquitously expressing it in ufo loss-of-function flowers at different developmental stages and for various durations using an ethanol-inducible expression system. The previously known functions of UFO could be separated and related to its expression at specific stages of development. We show that a 24- to 48-hour period of UFO expression from floral stage 2, before any floral organs are visible, is sufficient to restore normal petal and stamen development. The earliest requirement for UFO is during stage 2, when the endogenous UFO gene is transiently expressed in the centre of the wild-type flower and is required to specify the initiation patterns of petal, stamen and carpel primordia. Petal and stamen identity is determined during stages 2 or 3, when UFO is normally expressed in the presumptive second and third whorl. Although endogenous UFO expression is absent from the stamen whorl from stage 4 onwards, stamen identity can be restored by UFO activation up to stage 6. We also observed floral phenotypes not observed in loss-of-function or constitutive gain-of-function backgrounds, revealing additional roles of UFO in outgrowth of petal primordia.

  2. A continuous membrane microbioreactor system for development of integrated pectin modification and separation processes

    DEFF Research Database (Denmark)

    Zainal Alam, Muhd Nazrul Hisham Bin; Pinelo, Manuel; Samanta, Kama

    2011-01-01

    present a continuous membrane microbioreactor prototype for development of enzyme catalyzed degradation of pectin. Membrane reactors are becoming increasingly important for the novel ‘biorefining’ type of processes that either require product removal to avoid product inhibition or rest on partial...... hydrolysis of the substrate to obtain e.g. value-added oligosaccharides from complex biopolymers. The microbioreactor prototype was fabricated from poly(methylmethacrylate) (PMMA) and poly(dimethylsiloxane) (PDMS) and designed as a loop reactor (working volume approximately 190μL) integrated...... with a regenerated cellulose membrane for separation of low molecular weight products. The main technical considerations and challenges related to establishing the continuous membrane microbioreactor are discussed. The workability of the prototype was validated by comparing the process data at microscale to those...

  3. Developments for transactinide chemistry experiments behind the gas-filled separator TASCA

    Energy Technology Data Exchange (ETDEWEB)

    Even, Julia

    2011-12-13

    Topic of this thesis is the development of experiments behind the gas-filled separator TASCA (TransActinide Separator and Chemistry Apparatus) to study the chemical properties of the transactinide elements. In the first part of the thesis, the electrodepositions of short-lived isotopes of ruthenium and osmium on gold electrodes were studied as model experiments for hassium. From literature it is known that the deposition potential of single atoms differs significantly from the potential predicted by the Nernst equation. This shift of the potential depends on the adsorption enthalpy of therndeposited element on the electrode material. If the adsorption on the electrode-material is favoured over the adsorption on a surface made of the same element as the deposited atom, the electrode potential is shifted to higher potentials. This phenomenon is called underpotential deposition. Possibilities to automatize an electro chemistry experiment behind the gas-filled separator were explored for later studies with transactinide elements. The second part of this thesis is about the in-situ synthesis of transition-metal-carbonyl complexes with nuclear reaction products. Fission products of uranium-235 and californium-249 were produced at the TRIGA Mainz reactor and thermalized in a carbon-monoxide containing atmosphere. The formed volatile metal-carbonyl complexes could be transported in a gas-stream. Furthermore, short-lived isotopes of tungsten, rhenium, osmium, and iridium were synthesised at the linear accelerator UNILAC at GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt. The recoiling fusion products were separated from the primary beam and the transfer products in the gas-filled separator TASCA. The fusion products were stopped in the focal plane of TASCA in a recoil transfer chamber. This chamber contained a carbon-monoxide - helium gas mixture. The formed metal-carbonyl complexes could be transported in a gas stream to various experimental setups. All

  4. Development of a new class of flexible polymeric membranes for sensing, nanofiltration & cascaded separation

    Science.gov (United States)

    Du, Nian

    The last decade has witnessed an explosion of interests in the science and technology of engineered nanomaterials. While the benefits of nanotechnology are widely publicized, the discussion about the transformation of nanomaterials in the environment, and their potential impacts on human health has just begun. Nanoscale particles, whether ultrafine, nano, engineered, intentional, or incidental, pose significant health effects. New approaches for environmental monitoring of nanomaterials at high sensitivity and in real-time are particularly needed. Since nanoparticles must be isolated from complex environmental and biological matrices, the most effective and simple method of isolating engineered nanomaterials from air or water is filtration. Hence the overall project objective of this work is to develop innovative methods that can simultaneously remove, detect and inactivate diverse nanostructured materials. At the center of the technology is a novel class of polymeric filters capable of simultaneously removing and detecting metal and metal oxide nanoparticles. This project reports the development of a new class of self-standing, flexible, phase-inverted, poly(amic) acid membranes with experimentally-controlled nanopores ranging from less than 10nm to greater than 100nm. Compared to most commercial filter membranes, phase-inverted PAA membranes were found to exhibit superior durability and higher efficiency. The filtration efficiency was ˜99.97% for a number of nanoparticles including Quantum Dots, TiO2, Au and Ag. This work also showed that PAA membranes could be used to separate mixtures of nanoparticles. Although the separation does not show much selectivity according to the NPs’ chemical composition, it shows the ability to separate efficiently based on nanoparticle size. PAA showed an excellent performance not only for nanoparticle isolation at sub-nanometer size ranges, but also as a platform for the detection of engineered nanoparticles at low ppb levels

  5. Chemometric approach for development, optimization, and validation of different chromatographic methods for separation of opium alkaloids.

    Science.gov (United States)

    Acevska, J; Stefkov, G; Petkovska, R; Kulevanova, S; Dimitrovska, A

    2012-05-01

    The excessive and continuously growing interest in the simultaneous determination of poppy alkaloids imposes the development and optimization of convenient high-throughput methods for the assessment of the qualitative and quantitative profile of alkaloids in poppy straw. Systematic optimization of two chromatographic methods (gas chromatography (GC)/flame ionization detector (FID)/mass spectrometry (MS) and reversed-phase (RP)-high-performance liquid chromatography (HPLC)/diode array detector (DAD)) for the separation of alkaloids from Papaver somniferum L. (Papaveraceae) was carried out. The effects of various conditions on the predefined chromatographic descriptors were investigated using chemometrics. A full factorial linear design of experiments for determining the relationship between chromatographic conditions and the retention behavior of the analytes was used. Central composite circumscribed design was utilized for the final method optimization. By conducting the optimization of the methods in very rational manner, a great deal of excessive and unproductive laboratory research work was avoided. The developed chromatographic methods were validated and compared in line with the resolving power, sensitivity, accuracy, speed, cost, ecological aspects, and compatibility with the poppy straw extraction procedure. The separation of the opium alkaloids using the GC/FID/MS method was achieved within 10 min, avoiding any derivatization step. This method has a stronger resolving power, shorter analysis time, better cost/effectiveness factor than the RP-HPLC/DAD method and is in line with the "green trend" of the analysis. The RP-HPLC/DAD method on the other hand displayed better sensitivity for all tested alkaloids. The proposed methods provide both fast screening and an accurate content assessment of the six alkaloids in the poppy samples obtained from the selection program of Papaver strains.

  6. Development of the closed-loop Joule-Thomson cryoablation device for long area cooling

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Cheon Kyu; Park, Inn Yong; Yoo, Dong Gyu; Jeong, Sang Kwon [Cryogenic Engineering Laboratory, Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of); Park Sang Woo [Konkuk University Hospital, School of Medicine, Konkuk University, Seoul (Korea, Republic of)

    2013-09-15

    Cryoablation device is a surgical instrument to produce the cooling effect to destroy detrimental biological tissue by utilizing low temperature around 110 K. Usually, this device has the concentrated cooling region, so that it is suitable for concentrated and thick target. Accordingly, it is hard to apply this device for the target which is distributed and thin target. In this study, the design procedure of a closed-loop cryoablation device with multiple J-T expansion part is developed for the treatment of incompetent of great saphenous vein. The developed cyoablation device is designed with the analysis of 1-dimensional (1-D) bio-heat equation. The energy balance is considered to determine the minimum mass flow rate of refrigerant for consecutive flow boiling to develop the uniform cooling temperature. Azeotropic mixed refrigerant R410A and zeotropic mixed refrigerant (MR) of R22 (CHClF{sub 2}) and R23 (CHF{sub 3}) are utilized as operating fluids of the developed cryoablation device to form the sufficient temperature and to verify the quality of the inside of cryoablation probe. The experimental results of R410A and the zeotropic MR show the temperature non-uniformity over the range are 244.8K±2.7K and 239.8K±4.7K respectively. The experimental results demonstrate that the probe experiences the consecutive flow boiling over the target range of 200 mm.

  7. Developments for transactinide chemistry experiments behind the gas-filled separator TASCA

    International Nuclear Information System (INIS)

    Even, Julia

    2011-01-01

    Topic of this thesis is the development of experiments behind the gas-filled separator TASCA (TransActinide Separator and Chemistry Apparatus) to study the chemical properties of the transactinide elements. In the first part of the thesis, the electrodepositions of short-lived isotopes of ruthenium and osmium on gold electrodes were studied as model experiments for hassium. From literature it is known that the deposition potential of single atoms differs significantly from the potential predicted by the Nernst equation. This shift of the potential depends on the adsorption enthalpy of therndeposited element on the electrode material. If the adsorption on the electrode-material is favoured over the adsorption on a surface made of the same element as the deposited atom, the electrode potential is shifted to higher potentials. This phenomenon is called underpotential deposition. Possibilities to automatize an electro chemistry experiment behind the gas-filled separator were explored for later studies with transactinide elements. The second part of this thesis is about the in-situ synthesis of transition-metal-carbonyl complexes with nuclear reaction products. Fission products of uranium-235 and californium-249 were produced at the TRIGA Mainz reactor and thermalized in a carbon-monoxide containing atmosphere. The formed volatile metal-carbonyl complexes could be transported in a gas-stream. Furthermore, short-lived isotopes of tungsten, rhenium, osmium, and iridium were synthesised at the linear accelerator UNILAC at GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt. The recoiling fusion products were separated from the primary beam and the transfer products in the gas-filled separator TASCA. The fusion products were stopped in the focal plane of TASCA in a recoil transfer chamber. This chamber contained a carbon-monoxide - helium gas mixture. The formed metal-carbonyl complexes could be transported in a gas stream to various experimental setups. All

  8. Development of a Portable Two-Way Communication and Information Device for Deafblind People.

    Science.gov (United States)

    Ozioko, Oliver; Hersh, Marion

    2015-01-01

    This paper presents research on the development of a wearable two-way communication and information device for deafblind people who use tactile communications methods, namely the British deafblind manual alphabet and/or Braille. The device has two components: a glove worn by the deafblind person and a handheld display with keypad to be used by their hearing and sighted communication partner. Users can send messages using pressure sensors embedded in the glove and receive them by means of vibration on the palm. The two components are linked by Bluetooth and the use of Bluetooth to communicate with computers, mobile phones and other Bluetooth enabled devices is being investigated. The design was informed by feedback obtained from a survey of deafblind people and interviews with staff in two organisations for deafblind people. Research and development of the device is still ongoing.

  9. Research and development of lithium isotope separation using an ionic-liquid impregnated organic membrane

    International Nuclear Information System (INIS)

    Hoshino, Tsuyoshi

    2013-01-01

    The tritium needed as a fuel for fusion reactors is produced by the neutron capture reaction of lithium-6 ( 6 Li) in tritium breeding materials. However, natural Li contains only about 7.6 at.% 6 Li. In Japan, new lithium isotope separation technique using ionic-liquid impregnated organic membranes have been developed. The improvement in the durability of the ionic-liquid impregnated organic membrane is one of the main issues for stable, long-term operation of electrodialysis cells while maintaining good performance. Therefore, we developed highly-durable ionic-liquid impregnated organic membrane. Both ends of the ionic-liquid impregnated organic membrane were covered by a nafion 324 overcoat to prevent the outflow of the ionic liquid. The transmission of Lithium aqueous solution after 10 hours under the highly-durable ionic-liquid impregnated organic membrane is almost 13%. So this highly-durable ionic-liquid impregnated organic membrane for long operating of electrodialysis cells has been developed through successful prevention of ion liquid dissolution. (J.P.N.)

  10. Development of silver impregnated alumina for iodine separation from off-gas streams

    Energy Technology Data Exchange (ETDEWEB)

    Funabashi, Kiyomi; Fukasawa, Tetsuo; Kikuchi, Makoto [Energy Research Laboratory, Hitachi (Japan)] [and others

    1995-02-01

    An inorganic iodine adsorbent, silver impregnated alumina (AgA), has been developed to separate iodine effectively from off-gas streams of nuclear facilities and to decrease the volume of waste (spent adsorbent). Iodine removal efficiency was improved at relatively high humidity by using alumina carrier with two different pore diameters. Waste volume reduction was achieved by impregnating relatively large amounts of silver into the alumina pores. The developed adsorbent was tested first with simulated off-gas streams under various experimental conditions and finally with actual off-gas streams of the Karlsruhe reprocessing plant. The decontamination factor (DF) was about 100 with the AgA bed depth of 2cm at 70% relative humidity, which was a DF one order higher than that when AgA with one pore size was used. Iodine adsorption capacity was checked by passing excess iodine into the AgA bed. Values were about 0.12 and 0.35 g-I/cm`-AgA bed for 10 and 24wt% silver impregnated AgA, respectively. The results obtained in this study demonstrated the applicability of the developed AgA to the off-gas treatment system of nuclear facilities.

  11. Development of heavy-ion irradiation technique for single-event in semiconductor devices

    Energy Technology Data Exchange (ETDEWEB)

    Nemoto, Norio; Akutsu, Takao; Matsuda, Sumio [National Space Development Agency of Japan, Tsukuba, Ibaraki (Japan). Tsukuba Space Center; Naitoh, Ichiro; Itoh, Hisayoshi; Agematsu, Takashi; Kamiya, Tomihiro; Nashiyama, Isamu

    1997-03-01

    Heavy-ion irradiation technique has been developed for the evaluation of single-event effects on semiconductor devices. For the uniform irradiation of high energy heavy ions to device samples, we have designed and installed a magnetic beam-scanning system in a JAERI cyclotron beam course. It was found that scanned area was approximately 4 x 2 centimeters and that the deviation of ion fluence from the average value was less than 7%. (author)

  12. Developing methodologies for source attribution. Glass phase separation in Trinitite using NF{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Koeman, Elizabeth C.; Simonetti, Antonio [Notre Dame Univ., IN (United States). Dept. of Civil and Environmental Engineering and Earth Sciences; McNamara, Bruce K.; Smith, Frances N. [Pacific Northwest National Laboratory, Richland, WA (United States). Nuclear Chemistry and Engineering; Burns, Peter C. [Notre Dame Univ., IN (United States). Dept. of Civil and Environmental Engineering and Earth Sciences; Notre Dame Univ., IN (United States). Dept. of Chemistry and Biochemistry

    2017-08-01

    This study details thermal reactions between glasses, common minerals, and Trinitite post-detonation material with the fluorinating agent nitrogen trifluoride (NF{sub 3}). The ultimate goal of our investigation is to develop a relatively rapid method for the effective separation of bomb components from complex matrices resulting from a nuclear explosion. Trinitite samples, silicate minerals (quartz; plagioclase and microcline), amorphous SiO{sub 2}, calcite, a natural glass (obsidian), and two synthetic glasses were characterized extensively before and after the fluorination to fully understand the effects of the NF{sub 3} thermal treatment. Samples were reacted with NF{sub 3} using a combined thermogravimetric (TG) differential thermal analysis (DTA) unit, as well as in a stainless steel bomb reactor connected to a fluorination line. Subsequent to the NF{sub 3} treatment, samples were imaged by scanning electron microscopy in order to document changes in grain size and morphology. Energy dispersive spectroscopy was performed to determine changes in major element abundances. Results demonstrate that rates of reaction are dependent on grain size, temperature, pressure, and time of fluorination. All mineral samples experienced mass loss during fluorination. Specifically, amorphous SiO{sub 2} (∝90% mass loss) experienced the most while calcite experienced the least (∝18%). Major element analysis reveals that mass loss is attributable to the volatilization of silica (SiO{sub 2}) in Si-bearing phases, or sample decomposition in calcite due to fluorination. Results for fluorinated samples of Trinitite demonstrate that mass loss occurs at different rates for each sample, but each sample experienced an expected large decrease in Si content (resulting from volatilization of SiF{sub 4}). Hence, the concentration of metals in the residual material increased due to the volatilization of Si. These results validate that this thermal-fluorination technique allows the

  13. Development of a higher capacity, lower pressure drop steam/water separator with reduced primary-to-secondary spacing

    International Nuclear Information System (INIS)

    Pruster, W.P.; Kidwell, J.H.; Eaton, A.M.; Wall, J.R.

    1985-01-01

    The goal of this development effort was to double the steam flow capacity of an existing module steam/water separator design without significantly increasing the pressure drop while simultaneously minimizing the vertical distance (spacing) between the primary and secondary separation stages. The development work included extensive air/water and steam/water testing. The steam/water tests were performed at a common pressure of 300 psia (2.1 MPa) with comparable water and steam flows

  14. Development of the ELEX process for tritium separation at reprocessing plants

    International Nuclear Information System (INIS)

    Bruggeman, A.; Meynendonckx, L.; Parmentier, C.; Goossens, W.R.A.; Baetsle, L.H.

    1985-01-01

    The ELEX process for isotopic enrichment and separation of tritium from aqueous reprocessing effluents is described. After the development of an appropriate hydrophobic catalyst and the study of the separate constituent steps of the ELEX process, an integrated bench-scale installation with a detritiation capacity of 10 mol water per hour was constructed. It comprises essentially a 1.5 kW electrolyser and two 2 cm diameter by 3 m high exchange columns. In this mini-pilot the ELEX process was successfully demonstrated by detritiating more than 1000 dm 3 water containing up to 100 mCi tritium per dm 3 , which is the feed concentration expected for application of the process in a reprocessing plant. The process decontamination factor was always larger than 100 and the overall tritium balance could be kept within the experimental errors of the various measurements. Depending on the duration of the runs, the volume reduction factor was between 10 and 15, but this factor will become much higher when the present electrolyser will be replaced by the low-volume one now under construction at S.C.K./C.E.N. The technical availability of the mini-pilot amounted to 99% or more for the last experiments. During the nearly 6000 hours of operation there were no tritium contamination problems. At present the construction of a 280 mol.h -1 or 0.12 m 3 H 2 O (HTO) per day pilot detritiation installation nears completion. In this unit, which will have a total tritium inventory of maximum 1000 Ci, the ELEX process will be demonstrated with a volume reduction factor of 100 and a process decontamination factor of 100. Again the feed concentration will be 100 Ci tritium per m 3 . In the future this installation will be supplemented with a pre-treatment unit for the removal of fission products, organics and nitric acid

  15. Development of Self-Assembled Nanoscale Templates via Microphase Separation Induced by Polymer Brushes

    Science.gov (United States)

    Chu, Elza

    Phase separation in soft matter has been the crucial element in generating hybrid materials, such as polymer blends and mixed polymer brushes. This dissertation discusses two methods of developing self-assembled nanoscale templates via microphase separation induced by polymer brush synthesis. This work introduces a novel soft substrate approach with renewable grafting sites where polyacrylamide is "grafted through" chitosan soft substrates. The mechanism of grafting leads to ordered arrays of filament-like nanostructures spanning the chitosan-air interface. Additionally, the chemical composition of the filaments allows for post-chemical modification to change the physical properties of the filaments, and subsequently tailor surfaces for specific application. Unlike traditional materials, multi-functional or "smart" materials, such as binary polymer brushes (BPB) are capable of spontaneously changing the spatial distribution of functional groups and morphology at the surface upon external stimuli. Although promising in principle, the limited range of available complementary polymers with common non-selective solvents confines the diversity of usable materials and restricts any further advancement in the field. This dissertation also covers the fabrication and characterization of responsive nanoscale polystyrene templates or "mosaic" brushes that are capable of changing interfacial composition upon exposure to varying solvent qualities. Using a "mosaic" brush template is a unique approach that allows the fabrication of strongly immiscible polymer BPB without the need for a common solvent. The synthesis of such BPB is exemplified by two strongly immiscible polymers, i.e. polystyrene (polar) and polyacrylamide (non-polar), where polyacrylamide brush is "graft through" a Si-substrate modified with the polystyrene collapsed "mosaic" brush. The surface exhibits solvent-triggered responses, as well as application potential for anti-biofouling.

  16. The development of membrane based high purity oily water separators for use in Arctic waters

    Energy Technology Data Exchange (ETDEWEB)

    Peng, H.; Tremblay, A.Y. [Ottawa Univ., ON (Canada). Dept. of Chemical Engineering, Industrial Membrane Centre; Veinot, D.E. [Defence Research and Development Canada, Halifax, NS (Canada)

    2005-07-01

    With increased exploration and industrial activity in the Canadian Arctic, interest in the Northwest Passage as a shipping route has also increased. The oily wastewater produced by ships must be treated prior to discharge, particularly in the sensitive Arctic environment where biodegradation of organics is very slow due to cold climatic conditions and low sunlight. As such, safe techniques are needed for the treatment of oily wastewater released from ships. However, bilge water is difficult to treat because it contains seawater, particulates, used oils and detergents. Membrane based oily water separators (OWS) are considered to be a key technology for the treatment of bilge water onboard ships. The issues that must be taken into account in the ship-born use of membrane based OWS include the proper treatment of the oily brine before discharge; the substantial reduction in volume that is required; the complexity of the technology; labour associated with the operation of the system due to filter changes and cleaning; and, system automation to simplify its operation. In this study, a membrane-based process for treating bilge water was developed to meet stringent discharge regulations for discharge in Arctic waters. Currently, this discharge limit is set at 0 ppm. A pilot scale membrane cascade system was designed and evaluated. Multilumen ceramic membranes were used in the first stage and Sepa{sup R} test cells were used in the second stage. Optimal membrane pore size was determined. The study investigated the separation of oil and grease using different molecular weight cut-off (MWCO) membranes. The study revealed that through proper membrane design, it is possible to remove oil and grease from bilge water to a level permitting its discharge to Arctic waters. However, it was recommended that low level aromatic diesel fuels be used in ships operating in Arctic waters since the presence of soluble aromatics in diesel fuel increases the technical difficulty of reaching

  17. Separate development of the maxilla and mandible is controlled by regional signaling of the maxillomandibular junction during avian development.

    Science.gov (United States)

    Tak, Hye-Jin; Park, Tae-Jin; Piao, Zhenngu; Lee, Sang-Hwy

    2017-01-01

    Syngnathia is a congenital craniofacial disorder characterized by bony or soft tissue fusion of upper and lower jaws. Previous studies suggested some causative signals, such as Foxc1 or Bmp4, cause the disruption of maxillomandibular identity, but their location and the interactive signals involved remain unexplored. We wanted to examine the embryonic origin of syngnathia based on the assumption that it may be located at the separation between the maxillary and mandibular processes. This region, known as the maxillomandibular junction (MMJ), is involved in segregation of cranial neural crest-derived mesenchyme into the presumptive upper and lower jaws. Here we investigated the role of Fgf, Bmp, and retinoid signaling during development of MMJ in chicken embryos. By changing the levels of these signals with bead implants, we induced syngnathia with microstomia on the treated side, which showed increased Barx1 and neural cell adhesion molecule (NCAM) expression. Redistribution of proliferating cells was also observed at the proximal region to maxillary and mandibular arch around MMJ. We propose that interactive molecular signaling by Fgfs, Bmps, and retinoids around MMJ is required for normal separation of the maxilla and mandible, as well as the proper positioning of beak commissure during early facial morphogenesis. Developmental Dynamics 246:28-40, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  18. Development and application of a double-piston configured, total-liquid ventilatory support device.

    Science.gov (United States)

    Meinhardt, J P; Quintel, M; Hirschl, R B

    2000-05-01

    Perfluorocarbon liquid ventilation has been shown to enhance pulmonary mechanics and gas exchange in the setting of respiratory failure. To optimize the total liquid ventilation process, we developed a volume-limited, time-cycled liquid ventilatory support, consisting of an electrically actuated, microprocessor-controlled, double-cylinder, piston pump with two separate limbs for active inspiration and expiration. Prospective, controlled, animal laboratory study, involving sequential application of conventional gas ventilation, partial ventilation (PLV), and total liquid ventilation (TLV). Research facility at a university medical center. A total of 12 normal adult New Zealand rabbits weighing 3.25+/-0.1 kg. Anesthestized rabbits were supported with gas ventilation for 30 mins (respiratory rate, 20 cycles/min; peak inspiratory pressure, 15 cm H2O; end-expiratory pressure, 5 cm H2O), then PLV was established with perflubron (12 mL/kg). After 15 mins, TLV was instituted (tidal volume, 18 mL/kg; respiratory rate, 7 cycles/min; inspiratory/expiratory ratio, 1:2 cycles/min). After 4 hrs of TLV, PLV was re-established. Of 12 animals, nine survived the 4-hr TLV period. During TLV, mean values +/- SEM were as follows: PaO2, 363+/-30 torr; PaCO2, 39+/-1.5 torr; pH, 7.39+/-0.01; static peak inspiratory pressure, 13.2+/-0.2 cm H2O; static endexpiratory pressure, 5.5+/-0.1 cm H2O. No significant changes were observed. When compared with gas ventilation and PLV, significant increases occurred in mean arterial pressure (62.4+/-3.5 torr vs. 74.0+/-1.2 torr) and central venous pressure (5.6+/-0.7 cm H2O vs. 7.8+/-0.2 cm H2O) (p piston pumps with active expiration. Considering the enhanced flow profiles, this device configuration provides advantages over others.

  19. Microfabricated modular scale-down device for regenerative medicine process development.

    Directory of Open Access Journals (Sweden)

    Marcel Reichen

    Full Text Available The capacity of milli and micro litre bioreactors to accelerate process development has been successfully demonstrated in traditional biotechnology. However, for regenerative medicine present smaller scale culture methods cannot cope with the wide range of processing variables that need to be evaluated. Existing microfabricated culture devices, which could test different culture variables with a minimum amount of resources (e.g. expensive culture medium, are typically not designed with process development in mind. We present a novel, autoclavable, and microfabricated scale-down device designed for regenerative medicine process development. The microfabricated device contains a re-sealable culture chamber that facilitates use of standard culture protocols, creating a link with traditional small-scale culture devices for validation and scale-up studies. Further, the modular design can easily accommodate investigation of different culture substrate/extra-cellular matrix combinations. Inactivated mouse embryonic fibroblasts (iMEF and human embryonic stem cell (hESC colonies were successfully seeded on gelatine-coated tissue culture polystyrene (TC-PS using standard static seeding protocols. The microfluidic chip included in the device offers precise and accurate control over the culture medium flow rate and resulting shear stresses in the device. Cells were cultured for two days with media perfused at 300 µl.h(-1 resulting in a modelled shear stress of 1.1×10(-4 Pa. Following perfusion, hESC colonies stained positively for different pluripotency markers and retained an undifferentiated morphology. An image processing algorithm was developed which permits quantification of co-cultured colony-forming cells from phase contrast microscope images. hESC colony sizes were quantified against the background of the feeder cells (iMEF in less than 45 seconds for high-resolution images, which will permit real-time monitoring of culture progress in future

  20. The use of virtual prototyping and simulation in ITER maintenance device development

    International Nuclear Information System (INIS)

    Mattila, J.; Siuko, M.; Saarinen, H.; Maekinen, H.; Verho, S.; Vilenius, M.; Palmer, J.; Irving, M.

    2006-01-01

    The ITER divertor maintenance takes place approximately every second year. The maintenance occurs in very harsh and mechanically complicated environment. Due to the critical nature of the maintenance operations, the maintenance equipment design and the operation cycle will be verified in DTP2 test platform, in Tampere, Finland. TUT/IHA is working on the ITER divertor maintenance devices. Due to the complexity of the operation environment and tasks to be performed, 3d models and kinematic simulation have been valuable tool when developing the devices. Further, IHA has integrated to the models also dynamic properties of the device, so that it can be discussed as a virtual prototype. The virtual prototype can be used to verify the operation of the device, the operation cycle and also as a platform for developing the control software for the device. For device development, the virtual prototype is used to analyze the dynamic behavior, loading and flexibility of the device. The virtual prototype was also connected to real hardware to verify the operation of one joint. Then, the virtual model in computer was run and the output of the joints was given to a hydraulic cylinder representing disturbance load for an other hydraulic cylinder, which was operating under control software and aiming to move smoothly regardless of the disturbance load. By that way we were able to verify that the real system operates close enough with the simulation model. The virtual model is also used to shorten the time to get the DTP2 platform working. The CMM control software is done with virtual models as ready as possible. The CMM virtual model is connected to one-joint control hardware which allows developing the controller software one joint at time. In this paper, also other possibilities to use virtual prototypes in ITER divertor maintenance development are discussed. (author)

  1. Helical-type device and laser fusion. Rivals for tokamak-type device at n-fusion development in Japan

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    Under the current policy on the research and development of nuclear fusion in Japan, as enunciated by the Atomic Energy Commission of Japan, the type of a prototype fusion reactor will be chosen after 2020 from tokamak, helical or some other type including the inertial confinement fusion using lasers. A prototype fusion reactor is the next step following the tokamak type International Thermonuclear Experimental Reactor (ITER). With the prototype reactor, the feasibility as a power plant will be examined. At present the main research and development of nuclear fusion in Japan are on tokamak type, which have been promoted by Japan Atomic Energy Research Institute (JAERI). As for the other types of nuclear fusion, researches have been carried out on the helical type in Kyoto University and National Institute for Fusion Science (NIFS), the mirror type in Tsukuba University, the tokamak type using superconductive coils in Kyushu University, and the laser fusion in Osaka University. The features and the present state of research and development of the Large Helical Device and the laser fusion which is one step away from the break-even condition are reported. (K.I.)

  2. Early assessment of medical devices in development for company decision making : An exploration of best practices

    NARCIS (Netherlands)

    Markiewicz, Katarzyna; Van Til, Janine; IJzerman, Maarten

    2017-01-01

    To improve successful development and clinical use of medical technologies, it is suggested that manufacturers should start collecting evidence on devices effectiveness and eficiency early in their development. The aim of this study was to explore whether and how Dutch manufacturers perform an early

  3. Development of Wave Energy Devices: The Danish Case / The Dragon of Nissum Bredning

    DEFF Research Database (Denmark)

    Kofoed, Jens Peter; Frigaard, Peter

    2009-01-01

    The paper presents the Danish case of development of wave energy devices and outlines the established best practice. A brief overview of international standardization efforts is given and the Danish involvement in this described. The developed Danish best practice, which is being carried over to ...

  4. CSIR research, development and innovation initiatives for the medical device and diagnostic industry

    CSIR Research Space (South Africa)

    Vilakazi, Busisiwe

    2017-10-01

    Full Text Available This presentation is focused on development and innovation initiatives in the medical device and diagnostic industry. It is presented by Dr Busisiwe Vilakasi at The 6th CSIR Conference: Ideas that work for industrial development, 5-6 October 2017...

  5. Development and Testing of an Integrated Sandia Cooler Thermoelectric Device (SCTD).

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Terry A.; Staats, Wayne Lawrence,; Leick, Michael Thomas; Zimmerman, Mark D.; Radermacher, Reinhard; Martin, Cara; Nasuta, Dennis; Kalinowski, Paul; Hoffman, William

    2014-12-01

    This report describes a FY14 effort to develop an integrated Sandia Cooler T hermoelectric D evice (SCTD) . The project included a review of feasible thermoelectric (TE) cooling applications, baseline performance testing of an existing TE device, analysis and design development of an integrated SCTD assembly, and performance measurement and validation of the integrated SCTD prototype.

  6. Development of a Very High Cycle Fatigue (VHCF multiaxial testing device

    Directory of Open Access Journals (Sweden)

    M. Vieira

    2016-07-01

    Full Text Available The very high cycle region of the S-N fatigue curve has been the subject of intensive research on the last years, with special focus on axial, bending, torsional and fretting fatigue tests. Very high cycle fatigue can be achieved using ultrasonic exciters which allow for frequency testing of up to 30 kHz. Still, the multiaxial fatigue analysis is not yet developed for this type of fatigue analyses, mainly due to conceptual limitations of these testing devices. In this paper, a device designed to produce biaxial fatigue testing using a single piezoelectric axial exciter is presented, as well as the preliminary testing of this device. The device is comprised of a horn and a specimen, which are both attached to the piezoelectric exciter. The steps taken towards the final geometry of the device are presented. Preliminary experimental testing of the developed device is made using thermographic imaging, strain measurements and vibration speeds and indicates good behaviour of the tested specimen.

  7. A new automatic design method to develop multilayer thin film devices for high power laser applications

    International Nuclear Information System (INIS)

    Sahoo, N.K.; Apparao, K.V.S.R.

    1992-01-01

    Optical thin film devices play a major role in many areas of frontier technology like development of various laser systems to the designing of complex and precision optical systems. Design and development of these devices are really challenging when they are meant for high power laser applications. In these cases besides desired optical characteristics, the devices are expected to satisfy a whole range of different needs like high damage threshold, durability etc. In the present work a novel completely automatic design method based on Modified Complex Method has been developed for designing of high power thin film devices. Unlike most of the other methods it does not need any suitable starting design. A quarterwave design is sufficient to start with. If required, it is capable of generating its own starting design. The computer code of the method is very simple to implement. This report discusses this novel automatic design method and presents various practicable output designs generated by it. The relative efficiency of the method along with other powerful methods has been presented while designing a broadband IR antireflection coating. The method is also incorporated with 2D and 3D electric field analysis programmes to produce high damage threshold designs. Some experimental devices developed using such designs are also presented in the report. (author). 36 refs., 41 figs

  8. 78 FR 68459 - Medical Device Development Tools; Draft Guidance for Industry, Tool Developers, and Food and Drug...

    Science.gov (United States)

    2013-11-14

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-D-1279] Medical Device Development Tools; Draft Guidance for Industry, Tool Developers, and Food and Drug Administration Staff; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food...

  9. Research trend in thermally stimulated current method for development of materials and devices in Japan

    Science.gov (United States)

    Iwamoto, Mitsumasa; Taguchi, Dai

    2018-03-01

    Thermally stimulated current (TSC) measurement is widely used in a variety of research fields, i.e., physics, electronics, electrical engineering, chemistry, ceramics, and biology. TSC is short-circuit current that flows owing to the displacement of charges in samples during heating. TSC measurement is very simple, but TSC curves give very important information on charge behaviors. In the 1970s, TSC measurement contributed greatly to the development of electrical insulation engineering, semiconductor device technology, and so forth. Accordingly, the TSC experimental technique and its analytical method advanced. Over the past decades, many new molecules and advanced functional materials have been discovered and developed. Along with this, TSC measurement has attracted much attention in industries and academic laboratories as a way of characterizing newly discovered materials and devices. In this review, we report the latest research trend in the TSC method for the development of materials and devices in Japan.

  10. Development and validation of the downhole freestanding shear device (DFSD) for measuring the dynamic properties of clay.

    Science.gov (United States)

    2008-12-01

    The Downhole Freestanding Shear Device (DFSD) is an innovative tool developed for in situ measurement of dynamic : properties (modulus and damping) of clay soils over a broad range of strains. The device essentially performs : laboratory-quality tors...

  11. Steam-water separator

    International Nuclear Information System (INIS)

    Modrak, T.M.; Curtis, R.W.

    1978-01-01

    A two-stage steam-water separating device is introduced, where the second stage is made as a cyclone separator. The water separated here is collected in the first stage of the inner tube and is returned to the steam raising unit. (TK) [de

  12. Research and development prospects for the atomic uranium laser isotope separation process. Research report 442

    International Nuclear Information System (INIS)

    Janes, G.S.; Forsen, H.K.; Levy, R.H.

    1977-06-01

    Research and development activities are being conducted on many aspects of the atomic uranium laser isotope separation process. Extensive laser spectroscopy studies have been made in order to identify attractive multi-step selective ionization schemes. Using low density (10 10 atoms/cm 3 ) apparatus, the excited state spectra of atomic uranium have been investigated via multiple step laser excitation and photoionization studies using two, three and four pulsed lasers. Observation of the spectra was accomplished by observing the yield of 235 U and 238 U ions as a function of the wavelength, intensities and delays of the various lasers. These data yielded information on the photoexcitation and photoionizatin cross sections, and on the location, J values, lifetimes, isotope shifts and hyperfine structure of the various atomic levels of uranium. Experiments on selective ionization of uranium vapor by multiple step laser excitation followed by ion extraction at 10 13 atoms/cm 3 density have produced 6% enriched 235 U. These indicate that this process is well adapted to produce light water reactor fuel but less suitable for highly enriched material. Application has been made for license for a 1979 experimental facility to provide data for a mid-1980 commercial plant

  13. Microfluidic high gradient magnetic cell separation

    Science.gov (United States)

    Inglis, David W.; Riehn, Robert; Sturm, James C.; Austin, Robert H.

    2006-04-01

    Separation of blood cells by native susceptibility and by the selective attachment of magnetic beads has recently been demonstrated on microfluidic devices. We discuss the basic principles of how forces are generated via the magnetic susceptibility of an object and how microfluidics can be combined with micron-scale magnetic field gradients to greatly enhance in principle the fractionating power of magnetic fields. We discuss our efforts and those of others to build practical microfluidic devices for the magnetic separation of blood cells. We also discuss our attempts to integrate magnetic separation with other microfluidic features for developing handheld medical diagnostic tools.

  14. [Development of a massage device based on microcontroller in the field of alimentary tract].

    Science.gov (United States)

    Huang, Rong; Peng, Chenglin; He, Hongmei; Zhu, Jing

    2007-12-01

    In this artical is first reported a survey of the progress in research of MEMS technology. Then, the basic structure, features and the principles of a massage device based on microcontroller in the field of alimentary tract are introduced. Special emphasis is laid on the utilization of MSP430F123 microprocessor for producing a kind of period pulse to control the power of massage capsule. In general, the research and development of the massage device in the field of alimentary tract have active support and deep significance to therapy in the clinical and business settings as well as in the development of biomedical engineering and MEMS.

  15. Development of automated ultrasonic device for in-service inspection of ABWR pressure vessel bottom head

    International Nuclear Information System (INIS)

    Kojima, Y.; Matsuyama, A.

    1995-01-01

    An automated device and its controller have been developed for the bottom head weld examination of pressure vessel of Advanced Boiling Water Reactor (ABWR). The internal pump casings and the housings of control rod prevent a conventional ultrasonic device from scanning the required inspection zone. With this reason, it is required to develop a new device to examine the bottom head area of ABWR. The developed device is characterized by the following features. (1) Composed of a mother vehicle and a compact inspection vehicle. They are connected only by an electric wire without using the conventional arm mechanism. (2) The mother vehicle travels on a track and lift up the inspection vehicle to the vessel. (3) The mother vehicle can automatically attach the inspection vehicle to the bottom head, and detach the inspection vehicle from it. (4) Collision avoidance control function with a touch sensor is installed at the front of the inspection vehicle. The device was successfully demonstrated using a mock-up of reactor pressure vessel

  16. Development and evaluation of a novel smart device-based application for burn assessment and management.

    Science.gov (United States)

    Godwin, Zachary; Tan, James; Bockhold, Jennifer; Ma, Jason; Tran, Nam K

    2015-06-01

    We have developed a novel software application that provides a simple and interactive Lund-Browder diagram for automatic calculation of total body surface area (TBSA) burned, fluid formula recommendations, and serial wound photography on a smart device platform. The software was developed for the iPad (Apple, Cupertino, CA) smart device platforms. Ten burns ranging from 5 to 95% TBSA were computer generated on a patient care simulator using Adobe Photoshop CS6 (Adobe, San Jose, CA). Burn clinicians calculated the TBSA first using a paper-based Lund-Browder diagram. Following a one-week "washout period", the same clinicians calculated TBSA using the smart device application. Simulated burns were presented in a random fashion and clinicians were timed. Percent TBSA burned calculated by Peregrine vs. the paper-based Lund-Browder were similar (29.53 [25.57] vs. 28.99 [25.01], p=0.22, n=7). On average, Peregrine allowed users to calculate burn size significantly faster than the paper form (58.18 [31.46] vs. 90.22 [60.60]s, p<0.001, n=7). The smart device application also provided 5 megapixel photography capabilities, and acute burn resuscitation fluid calculator. We developed an innovative smart device application that enables accurate and rapid burn size assessment to be cost-effective and widely accessible. Copyright © 2014 Elsevier Ltd and ISBI. All rights reserved.

  17. Development of a pellet cutting and loading device for the JT-60 repetitive pellet injector

    International Nuclear Information System (INIS)

    Hiratsuka, Hajime; Ichige, Hisashi; Kizu, Kaname; Iwahashi, Takaaki; Honda, Masao

    2001-03-01

    In JT-60, a pellet injector that repetitively injects deuterium pellets is under development to supply fuel to high temperature plasmas and sustain high-density plasmas. The pellet injector generates cubic pellets and accelerates them with a straight-arm rotor by centrifugal force. In this acceleration method, it is important to supply pellets reliably and stably, to prevent pellet orbits from disordering and to stabilize the launching direction. To achieve higher performance of the injector, a pellet cutting and loading device that cuts a deuterium ice rod into cubic pellets and loads them to the pellet injector successively and stably has been developed. The pellet cutting and loading device can cut a deuterium ice rod produced at low temperature of -8 Pam 3 /s, cutting time of <3 ms, cutting frequency of 1-20 Hz and cutter stroke of 2.5 mm were confirmed in the device test. In the operation test after assembling this device to the centrifugal pellet injector, the operational performance of pellet injection frequency of ∼10 Hz, pellet speed of ∼690 m/s and pellet injection duration time of ∼3.5 s was achieved. Thus, the development of the pellet cutting and loading device contributed to the upgrade of the JT-60 pellet injector. (author)

  18. The development of 126Sn separation procedure by means of TBP resin

    International Nuclear Information System (INIS)

    Andris, Boris; Bena, Jozef

    2016-01-01

    Separation possibilities of 126 Sn with a new extraction-chromatographic material TBP Resin were studied. Suitable conditions for tin separation were determined in hydrochloric acid medium. 126 Sn was concentrated on TBP resin from 6 mol L -1 HCl and was eluted with 0.1 mol L -1 HCl. A purification step to remove 137 Cs with AMP-PAN column was necessary to obtain sufficiently purified samples which were directly measured with gamma spectrometry for 126 Sn activity. Separation of 126 Sn from a raw sludge sample was done according to proposed procedure, 126 Sn was detected and its activity was determined. (author)

  19. Chromatographic separation and detection of contaminants from whole milk powder using a chitosan-modified silver nanoparticles surface-enhanced Raman scattering device.

    Science.gov (United States)

    Li, Dan; Lv, Di Y; Zhu, Qing X; Li, Hao; Chen, Hui; Wu, Mian M; Chai, Yi F; Lu, Feng

    2017-06-01

    Methods for the on-site analysis of food contaminants are in high demand. Although portable Raman spectroscopy is commonly used to test food on-site, it can be challenge to achieve this goal with rapid detection and inexpensive substrate. In this study, we detected trace food contaminants in samples of whole milk powder using the methods that combined chromatography with surface-enhanced Raman scattering detection (SERS). We developed a simple and efficient technique to fabricate the paper with chitosan-modified silver nanoparticles as a SERS-active substrate. The soaking time of paper and the concentration of chitosan solution were optimized for chromatographic separation and SERS detection. We then studied the separation properties for real applications including complex sample matrices, and detected melamine at 1mg/L, dicyandiamide at 100mg/L and sodium sulfocyanate at 10mg/L in whole milk powder. As such, our methods have great potential for field-based detection of milk contaminants. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Development of a colonoscopy add-on device for improvement of the intubation process

    Directory of Open Access Journals (Sweden)

    Litten JD

    2011-12-01

    Full Text Available Jonathan D Litten1, JungHun Choi2, David Drozek31Department of Mechanical Engineering; 2Department of Mechanical Engineering and Biomedical Engineering Program; 3College of Osteopathic Medicine, Department of Specialty Medicine, Ohio University, Athens, OH, USAAbstract: A colonoscopy add-on device has been developed to reduce intubation time without modification of the current colonoscope and peripheral devices. One of the main purposes of the system is to minimize trauma caused by the distal tip of the colonoscope. The detachable sensory fixture at the end of the distal tip measures the distance between the distal tip and the colon wall in three directions, and the actuation system attached at the base of the colonoscope controls the distal tip by rotating two dial knobs. The device controls the distal tip to minimize contact between the distal tip and the colon wall, and the distal tip ideally points out the next possible lumen. A compatibility test of the infrared sensory system was carried out, and the design of the actuation system was accomplished. The system is integrated and controlled by a microprocessor. The device was tested in a silicon colon and porcine intestine. The results showed that a colonoscopist successfully reached the cecum with the aid of the colonoscopy add-on device without significant contact between the colon wall and the distal tip. The colonoscopy aid device was very helpful for the novice colonoscopist.Keywords: colonoscope, infrared sensors, intubation, trauma, colonoscopy training model

  1. Development and control of a magnetorheological haptic device for robot assisted surgery.

    Science.gov (United States)

    Shokrollahi, Elnaz; Goldenberg, Andrew A; Drake, James M; Eastwood, Kyle W; Kang, Matthew

    2017-07-01

    A prototype magnetorheological (MR) fluid-based actuator has been designed for tele-robotic surgical applications. This device is capable of generating forces up to 47 N, with input currents ranging from 0 to 1.5 A. We begin by outlining the physical design of the device, and then discuss a novel nonlinear model of the device's behavior. The model was developed using the Hammerstein-Wiener (H-W) nonlinear black-box technique and is intended to accurately capture the hysteresis behavior of the MR-fluid. Several experiments were conducted on the device to collect estimation and validation datasets to construct the model and assess its performance. Different estimating functions were used to construct the model, and their effectiveness is assessed based on goodness-of-fit and final-prediction-error measurements. A sigmoid network was found to have a goodness-of-fit of 95%. The model estimate was then used to tune a PID controller. Two control schemes were proposed to eliminate the hysteresis behavior present in the MR fluid device. One method uses a traditional force feedback control loop and the other is based on measuring the magnetic field using a Hall-effect sensor embedded within the device. The Hall-effect sensor scheme was found to be superior in terms of cost, simplicity and real-time control performance compared to the force control strategy.

  2. Development of an elution device for ViroCap virus filters.

    Science.gov (United States)

    Fagnant, Christine Susan; Toles, Matthew; Zhou, Nicolette Angela; Powell, Jacob; Adolphsen, John; Guan, Yifei; Ockerman, Byron; Shirai, Jeffry Hiroshi; Boyle, David S; Novosselov, Igor; Meschke, John Scott

    2017-10-19

    Environmental surveillance of waterborne pathogens is vital for monitoring the spread of diseases, and electropositive filters are frequently used for sampling wastewater and wastewater-impacted surface water. Viruses adsorbed to electropositive filters require elution prior to detection or quantification. Elution is typically facilitated by a peristaltic pump, although this requires a significant startup cost and does not include biosafety or cross-contamination considerations. These factors may pose a barrier for low-resource laboratories that aim to conduct environmental surveillance of viruses. The objective of this study was to develop a biologically enclosed, manually powered, low-cost device for effectively eluting from electropositive ViroCap™ virus filters. The elution device described here utilizes a non-electric bilge pump, instead of an electric peristaltic pump or a positive pressure vessel. The elution device also fully encloses liquids and aerosols that could contain biological organisms, thereby increasing biosafety. Moreover, all elution device components that are used in the biosafety cabinet are autoclavable, reducing cross-contamination potential. This device reduces costs of materials while maintaining convenience in terms of size and weight. With this new device, there is little sample volume loss due to device inefficiency, similar virus yields were demonstrated during seeded studies with poliovirus type 1, and the time to elute filters is similar to that required with the peristaltic pump. The efforts described here resulted in a novel, low-cost, manually powered elution device that can facilitate environmental surveillance of pathogens through effective virus recovery from ViroCap filters while maintaining the potential for adaptability to other cartridge filters.

  3. Single-Ion Implantation for the Development of Si-Based MOSFET Devices with Quantum Functionalities

    Directory of Open Access Journals (Sweden)

    Jeffrey C. McCallum

    2012-01-01

    Full Text Available Interest in single-ion implantation is driven in part by research into development of solid-state devices that exhibit quantum behaviour in their electronic or optical characteristics. Here, we provide an overview of international research work on single ion implantation and single ion detection for development of electronic devices for quantum computing. The scope of international research into single ion implantation is presented in the context of our own research in the Centre for Quantum Computation and Communication Technology in Australia. Various single ion detection schemes are presented, and limitations on dopant placement accuracy due to ion straggling are discussed together with pathways for scale-up to multiple quantum devices on the one chip. Possible future directions for ion implantation in quantum computing and communications are also discussed.

  4. Use of a design challenge to develop postural support devices for intermediate wheelchair users

    Directory of Open Access Journals (Sweden)

    Brenda N. Onguti

    2017-09-01

    Full Text Available The provision of an appropriate wheelchair, one that provides proper fit and postural support, promotes wheelchair users’ physical health and quality of life. Many wheelchair users have postural difficulties, requiring supplemental postural support devices for added trunk support. However, in many low- and middle-income settings, postural support devices are inaccessible, inappropriate or unaffordable. This article describes the use of the design challenge model, informed by a design thinking approach, to catalyse the development of an affordable, simple and robust postural support device for low- and middle-income countries. The article also illustrates how not-for-profit organisations can utilise design thinking and, in particular, the design challenge model to successfully support the development of innovative solutions to product or process challenges.

  5. Development and Validation of a Prototype Vacuum Sensing Unit for the DD2011 Chairside Amalgam Separators

    Science.gov (United States)

    2015-10-30

    amalgam separators , such as the DD2011, remove amalgam waste particulates by filtration and are attached to the vacuum system of dental chairs for...based upon the principle that solid particulate amalgam waste and dental debris accumulate and block the movement of water through the filtration...AMALGAM SEPARATORS JAY SHARTZER, B.S., SOPHIA JOHNSON, PH.D., AND AMBER NAGY, PH.D. CRANIOFACIAL HEALTH AND RESTORATIVE MEDICINE BIOMATERIALS AND

  6. Development of novel separation techniques for biological samples in capillary electrophoresis

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Huan -Tsung [Iowa State Univ., Ames, IA (United States)

    1994-07-27

    This dissertation includes three different topics: general introduction of capillary electrophoresis (CE); gradient in CE and CE in biological separations; and capillary gel electrophoresis (CGE) for DNA separation. Factors such as temperature, viscosity, pH, and the surface of capillary walls affecting the separation performance are demonstrated. A pH gradient between 3.0 and 5.2 is useful to improve the resolution among eight different organic acids. A flow gradient due to the change in the concentration of surfactant, which is able to coat to the capillary wall to change the flow rate and its direction, is also shown as a good way to improve the resolution for organic compounds. A temperature gradient caused by joule heat is shown by voltage programming to enhance the resolution and shorten the separation time for several phenolic compounds. The author also shows that self-regulating dynamic control of electroosmotic flow in CE by simply running separation in different concentrations of surfactant has less matrix effect on the separation performance. One of the most important demonstrations in this dissertation is that the author proposes on-column reaction which gives several advantages including the use of a small amount of sample, low risk of contamination, and time saving and kinetic features. The author uses this idea with laser induced fluorescence (LIF) as a detection mode to detect an on-column digestion of sub-ng of protein. This technique also is applied to single cell analysis in the group.

  7. Design and development of a device to measure the deformities of clubfoot.

    Science.gov (United States)

    Khas, Kanwaljit S; Pandey, Pulak M; Ray, Alok R

    2015-03-01

    Clubfoot describes a range of foot abnormalities usually present at birth, in which the foot of a baby is twisted out of shape or position. In order to develop an effective treatment plan for clubfoot and/or assess the extent to which existing interventions are successful, medical practitioners need to be able to accurately measure the nature and extent of the deformity. This is typically performed using a goniometer. However, this device is only able to measure one dimension at a time. As such, a complete assessment of the condition of a foot can be extremely burdensome and time-consuming. This article describes a new device that can quickly and efficiently take several measurements on feet of various sizes and shapes. The use of this device was verified by measuring the deformities of real clubfeet. A silicone rubber clubfoot model was also used in this study to clearly illustrate the effectiveness with which the proposed device can measure the various deformities of clubfoot. It is envisaged that the use of this device will significantly reduce the time and effort orthopedists require to measure clubfoot deformities and develop and assess treatment plans. © IMechE 2015.

  8. Recent Developments in Optical Detection Technologies in Lab-on-a-Chip Devices for Biosensing Applications

    Directory of Open Access Journals (Sweden)

    Nuno Miguel Matos Pires

    2014-08-01

    Full Text Available The field of microfluidics has yet to develop practical devices that provide real clinical value. One of the main reasons for this is the difficulty in realizing low-cost, sensitive, reproducible, and portable analyte detection microfluidic systems. Previous research has addressed two main approaches for the detection technologies in lab-on-a-chip devices: (a study of the compatibility of conventional instrumentation with microfluidic structures, and (b integration of innovative sensors contained within the microfluidic system. Despite the recent advances in electrochemical and mechanical based sensors, their drawbacks pose important challenges to their application in disposable microfluidic devices. Instead, optical detection remains an attractive solution for lab-on-a-chip devices, because of the ubiquity of the optical methods in the laboratory. Besides, robust and cost-effective devices for use in the field can be realized by integrating proper optical detection technologies on chips. This review examines the recent developments in detection technologies applied to microfluidic biosensors, especially addressing several optical methods, including fluorescence, chemiluminescence, absorbance and surface plasmon resonance.

  9. Development of a High Sensitivity Digital Cerenkov Viewing Device. Prototype Digital Cerenkov Viewing Device. Field test in Sweden

    International Nuclear Information System (INIS)

    Chen, J.D.; Gerwing, A.F.; Lewis, P.D.; Larsson, M.; Jansson, K.; Lindberg, B.; Sundkvist, E.; Ohlsson, M.

    2002-05-01

    The Swedish and Canadian Safeguards Support Programs have developed a prototype Digital Cerenkov Viewing Device (DCVD) to verify long-cooled spent fuel. The instrument consists of a camera system and a custom portable computer equipped with a liquid crystal and a wearable heads-up display. The camera was coupled to a hardware user interface (HUI) and was operated with a computer program designed to image spent fuel and store the images. Measurements were taken at the CLAB facility on pressurized-water reactor fuel and non-fuel assemblies, a number of boiling-water reactor fuel assemblies, and long-cooled Aagesta fuel assemblies. The camera head, attached to the HUI, a battery-operated computer carried in a backpack and the heads-up display were field tested for portability. The ergonomics of this system is presented in the report. For the examination of long-cooled spent fuel, the camera head was mounted on a bracket that rested on the railing of a moving bridge. The DCVD instrument is approximately 100 times higher in sensitivity than the Mark IVe CVD. The oldest fuel with the lowest burnup at the CLAB facility was positively verified. The measurement capability of this instrument greatly exceeds the verification criteria of 10,000 MWd/t U and 40 years cooling

  10. Separation of pigment formulations by high-performance thin-layer chromatography with automated multiple development.

    Science.gov (United States)

    Stiefel, Constanze; Dietzel, Sylvia; Endress, Marc; Morlock, Gertrud E

    2016-09-02

    Food packaging is designed to provide sufficient protection for the respective filling, legally binding information for the consumers like nutritional facts or filling information, and an attractive appearance to promote the sale. For quality and safety of the package, a regular quality control of the used printing materials is necessary to get consistently good print results, to avoid migration of undesired ink components into the food and to identify potentially faulty ink batches. Analytical approaches, however, have hardly been considered for quality assurance so far due to the lack of robust, suitable methods for the analysis of rarely soluble pigment formulations. Thus, a simple and generic high-performance thin-layer chromatography (HPTLC) method for the separation of different colored pigment formulations was developed on HPTLC plates silica gel 60 by automated multiple development. The gradient system provided a sharp resolution for differently soluble pigment constituents like additives and coating materials. The results of multi-detection allowed a first assignment of the differently detectable bands to particular chemical substance classes (e.g., lipophilic components), enabled the comparison of different commercially available pigment batches and revealed substantial variations in the composition of the batches. Hyphenation of HPTLC with high resolution mass spectrometry and infrared spectroscopy allowed the characterization of single unknown pigment constituents, which may partly be responsible for known quality problems during printing. The newly developed, precise and selective HPTLC method can be used as part of routine quality control for both, incoming pigment batches and monitoring of internal pigment production processes, to secure a consistent pigment composition resulting in consistent ink quality, a faultless print image and safe products. Hyphenation of HPTLC with the A. fischeri bioassay gave first information on the bioactivity or rather

  11. Report on the achievements in research and development of a coal liquefaction technology in the Sunshine Project in fiscal 1981. Development of a solvent extraction and liquefaction plant (research and development of solid-liquid separation process); Sekitan ekika gijutsu no kenkyu kaihatsu, yozai chushutsu ekika plant no kaihatsu, koeki bunriho no kenkyu kaihatsu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1982-03-01

    Among researches on solvent extraction and liquefaction technologies in the Sunshine Project in fiscal 1981, this paper describes the achievements in development of a solid-liquid separation technology. In the research of operation of a centrifugal separation device, a solid-liquid separation test was performed on slurry extracted from the Australian Wandoan coal being sub-bituminous coal. The deliming rate has reached 99% equilibrium at an addition rate of 20% by weight of anti-solvent (a kind of normal paraffin, which reduces solubility of part of coal extracts and enhances removal rates of ash and solids by utilizing coagulating action of the extracts). Asphaltene among the liquefaction formed materials may be recovered nearly completely, but the recovery rate for pre-asphaltene was lower. An operation test was also carried out by using slurry extracted in a 1 t/d experimental plant. In the study on operation of a 5-l/h continuous sedimentation and separation device, a maximum effect was derived with addition of anti-solvent at 25% by weight and at a stirring rate of 700 rpm. The solid-liquid separability changes depending on the kind of slurry. The low conversion rate slurry becomes difficult of separation because its viscosity is high and the difference in density between solids and liquid is small. Furthermore, the high conversion rate slurry has become difficult of separation due to small particle size of the solids. (NEDO)

  12. Development of technique for laser welding of biological tissues using laser welding device and nanocomposite solder.

    Science.gov (United States)

    Gerasimenko, A; Ichcitidze, L; Podgaetsky, V; Ryabkin, D; Pyankov, E; Saveliev, M; Selishchev, S

    2015-08-01

    The laser device for welding of biological tissues has been developed involving quality control and temperature stabilization of weld seam. Laser nanocomposite solder applied onto a wound to be weld has been used. Physicochemical properties of the nanocomposite solder have been elucidated. The nature of the tissue-organizing nanoscaffold has been analyzed at the site of biotissue welding.

  13. Single atom doping for quantum device development in diamond and silicon

    NARCIS (Netherlands)

    Weis, C.D.; Schuh, A.; Batra, A.; Persaud, A.; Rangelow, I.W.; Bokor, J.; Lo, C.C.; Cabrini, S.; Sideras-Haddad, E.; Fuchs, G.D.; Hanson, R.; Awschalom, D.D.; Schenkel, T.

    2008-01-01

    The ability to inject dopant atoms with high spatial resolution, flexibility in dopant species, and high single ion detection fidelity opens opportunities for the study of dopant fluctuation effects and the development of devices in which function is based on the manipulation of quantum states in

  14. An analytic framework for developing inherently-manufacturable pop-up laminate devices

    International Nuclear Information System (INIS)

    Aukes, Daniel M; Goldberg, Benjamin; Wood, Robert J; Cutkosky, Mark R

    2014-01-01

    Spurred by advances in manufacturing technologies developed around layered manufacturing technologies such as PC-MEMS, SCM, and printable robotics, we propose a new analytic framework for capturing the geometry of folded composite laminate devices and the mechanical processes used to manufacture them. These processes can be represented by combining a small set of geometric operations which are general enough to encompass many different manufacturing paradigms. Furthermore, such a formulation permits one to construct a variety of geometric tools which can be used to analyze common manufacturability concepts, such as tool access, part removability, and device support. In order to increase the speed of development, reduce the occurrence of manufacturing problems inherent with current design methods, and reduce the level of expertise required to develop new devices, the framework has been implemented in a new design tool called popupCAD, which is suited for the design and development of complex folded laminate devices. We conclude with a demonstration of utility of the tools by creating a folded leg mechanism. (paper)

  15. The further development of the active urine collection device: a novel continence management system.

    Science.gov (United States)

    Tinnion, E; Jowitt, F; Clarke-O'Neill, S; Cottenden, A M; Fader, M; Sutherland, I

    2003-01-01

    Continence difficulties affect the lives of a substantial minority of the population. Women are far more likely than men to be affected by urinary incontinence but the range of management options for them is limited. There has been considerable interest in developing an external urine collection system for women but without success to date. This paper describes the development and preliminary clinical testing of an active urine collection device (AUCD), which could provide a solution for sufferers. The device uses stored vacuum, protected by a high bubble point filter, to remove urine as quickly as it is produced. This allows a small battery-operated pump to provide the required vacuum, enabling the device to be portable. Two different types of non-invasive patient/device interface were developed, and tested by volunteers: urinal and small pad. The slimline urinal was popular with users although liquid noise was a problem. The pad interface was successful on occasions but further work is necessary to produce a reliable pad. This study has successfully demonstrated that a prototype AUCD liquid handling system can remove urine at clinically relevant flowrates. While further development is required, volunteer tests have shown that the AUCD could be a useful advance in continence management.

  16. Development of combined low-emissions burner devices for low-power boilers

    Science.gov (United States)

    Roslyakov, P. V.; Proskurin, Yu. V.; Khokhlov, D. A.

    2017-08-01

    Low-power water boilers are widely used for autonomous heat supply in various industries. Firetube and water-tube boilers of domestic and foreign manufacturers are widely represented on the Russian market. However, even Russian boilers are supplied with licensed foreign burner devices, which reduce their competitiveness and complicate operating conditions. A task of developing efficient domestic low-emissions burner devices for low-power boilers is quite acute. A characteristic property of ignition and fuel combustion in such boilers is their flowing in constrained conditions due to small dimensions of combustion chambers and flame tubes. These processes differ significantly from those in open combustion chambers of high-duty power boilers, and they have not been sufficiently studied yet. The goals of this paper are studying the processes of ignition and combustion of gaseous and liquid fuels, heat and mass transfer and NO x emissions in constrained conditions, and the development of a modern combined low-emissions 2.2 MW burner device that provides efficient fuel combustion. A burner device computer model is developed and numerical studies of its operation on different types of fuel in a working load range from 40 to 100% of the nominal are carried out. The main features of ignition and combustion of gaseous and liquid fuels in constrained conditions of the flame tube at nominal and decreased loads are determined, which differ fundamentally from the similar processes in steam boiler furnaces. The influence of the burner devices design and operating conditions on the fuel underburning and NO x formation is determined. Based on the results of the design studies, a design of the new combined low-emissions burner device is proposed, which has several advantages over the prototype.

  17. The Development of Russian Legislation Relating to the Protection of the Rights of Separated Parents and Their Children

    Directory of Open Access Journals (Sweden)

    Tatiana Krasnova

    2017-01-01

    Full Text Available The following article deals with the challenges created by legal regulations concerning divorced or separated couples and focuses on the rights of separated parents with children. The article analyzes the problems associated with law enforcement practices in this area, the gaps in existing family law, as well as the disputed aspects of theory concerning parents’ legal relations. Suggestions for legislative developments in Russia concerning the protection of family rights within separated families are given. The authors of this paper argue for a rethink of existing approaches to legal regulations in this field of law due to the fact that existing family legislation does not take into consideration many of the challenges and realities of modern parenthood. Furthermore, current legal regulations in Russia do not fully correspond to international legal norms. The authors contend that this will lead to the curtailment of the legal rights of the separated parents. Such status is characterized, on the one hand, by unreasonable restrictions on parental rights. On the other hand, it permits only a limited degree of responsibility for a child’s upbringing and financial support on the part of a parent living separately from their child. The authors propose that, in this respect, it is necessary to rethink disputed legal decisions relating to family law and the implementation of family law in practice. By analyzing such implementation, the authors single out a number of interrelated factors that must be overcome in order to effectively protect separated parents’ relationships with their children. The aim of the article is to initiate a new approach to parental legal relations after divorce or separation and to propose new legislative regulations concerning the legal status of a parent who lives separately from their child. New developments in family law are proposed in order to ensure a balance between parental responsibilities and rights as well as

  18. Nebulized therapy. SEPAR year.

    Science.gov (United States)

    Olveira, Casilda; Muñoz, Ana; Domenech, Adolfo

    2014-12-01

    Inhaled drugs are deposited directly in the respiratory tract. They therefore achieve higher concentrations with faster onset of action and fewer side effects than when used systemically. Nebulized drugs are mainly recommended for patients that require high doses of bronchodilators, when they need to inhale drugs that only exist in this form (antibiotics or dornase alfa) or when they are unable to use other inhalation devices. Technological development in recent years has led to new devices that optimize pulmonary deposits and reduce the time needed for treatment. In this review we focus solely on drugs currently used, or under investigation, for nebulization in adult patients; basically bronchodilators, inhaled steroids, antibiotics, antifungals, mucolytics and others such as anticoagulants, prostanoids and lidocaine. Copyright © 2014 SEPAR. Published by Elsevier Espana. All rights reserved.

  19. Development of a low-frequency physiotherapeutic device for diabetes manipulated by microcontroller.

    Science.gov (United States)

    Guo, Jin-Song; Gong, Jian

    2001-01-01

    OBJECTIVE: To develop a physiotherapeutic device for diabetes that generates special low-frequency waveform manipulated by a microcontroller. METHODS: A microcontoller and a digital-to-analog converter were utilized along with a keyboard and LED display circuit, to generate desired low-frequecy waveform with the assistance of a software. RESULTS: The complex waveform generated by this device met the demands for diabetes physiotherapy, and the frequency and amplitude could be freely adjusted. CONCLUSIONS: The utilization of a digital-to-analog converter controlled by a microcontroller can very well serve the purpose of a low-frequency physiotherapy for diabetes.

  20. The development of display device for radioactive information using wireless communication

    International Nuclear Information System (INIS)

    Kim, Jung Taek; Park, Won Man; Lee, Bong Jae; Lim, Yoo Chung

    1998-06-01

    The improvement in the nuclear industry makes that it is important to protect personnel and equipment form radiation, because they have many chance to treat radioactive material. The head office on a prevention and an emergency measure for a radioactive release is necessary. In this study, display device for radioactive information using wireless communication has been developed to display a radioactivity using radio frequency modem. Therefore, the unlocated head office can be operated in a portable environment using a notebook PC or a compact display device. Korea Atomic Energy Research Institute, which runs a research reactor, HANARO, needs the head office on a prevention and an emergency measure for a radioactive release. The display device for radioactive information using wireless communication to be developed in this study, can be used to the head office as a display device not to pay additional cost. This study has developed the display device for radioactive information using wireless communication, Remote Radiation Display System(RRDS), which transmits every 10 second a radioactive information to be displayed to RMT(Radiation Monitoring Terminal) of Radiation Monitoring System in HANARO. In this study, first, a configuration of hardware and software in HANARO RMS has been reviewed. Second, a RS-2322C serial communication program to transmit a radioactive information in HARARO RMS to RRDS using radio frequency modem has been developed. Finally, a RS-2322C serial communication program to receive a radioactive information in HANARO RMS from RRDS using radio frequency modem and GUI program to display the received information to RRDS has been developed. (author). 19 refs., 3 tabs., 25 figs

  1. Development of novel nonvolatile memory devices using the colossal magnetoresistive oxide praseodymium-calcium-manganese trioxide

    Science.gov (United States)

    Papagianni, Christina

    Pr0.7Ca0.3MnO3 (PCMO) manganese oxide belongs in the family of materials known as transition metal oxides. These compounds have received increased attention due to their perplexing properties such as Colossal Magnetoresistance effect, Charge-Ordered phase, existence of phase-separated states etc. In addition, it was recently discovered that short electrical pulses in amplitude and duration are sufficient to induce reversible and non-volatile resistance changes in manganese perovskite oxide thin films at room temperature, known as the EPIR effect. The existence of the EPIR effect in PCMO thin films at room temperature opens a viable way for the realization of fast, high-density, low power non-volatile memory devices in the near future. The purpose of this study is to investigate, optimize and understand the properties of Pr0.7Ca0.3MnO 3 (PCMO) thin film devices and to identify how these properties affect the EPIR effect. PCMO thin films were deposited on various substrates, such as metals, and conducting and insulating oxides, by pulsed laser and radio frequency sputtering methods. Our objective was to understand and compare the induced resistive states. We attempted to identify the induced resistance changes by considering two resistive models to be equivalent to our devices. Impedance spectroscopy was also utilized in a wide temperature range that was extended down to 70K. Fitted results of the temperature dependence of the resistance states were also included in this study. In the same temperature range, we probed the resistance changes in PCMO thin films and we examined whether the phase transitions affect the EPIR effect. In addition, we included a comparison of devices with electrodes consisting of different size and different materials. We demonstrated a direct relation between the EPIR effect and the phase diagram of bulk PCMO samples. A model that could account for the observed EPIR effect is presented.

  2. Development of polymeric palladium-nanoparticle membrane-installed microflow devices and their application in hydrodehalogenation.

    Science.gov (United States)

    Yamada, Yoichi M A; Watanabe, Toshihiro; Ohno, Aya; Uozumi, Yasuhiro

    2012-02-13

    We have developed a variety of polymeric palladium-nanoparticle membrane-installed microflow devices. Three types of polymers were convoluted with palladium salts under laminar flow conditions in a microflow reactor to form polymeric palladium membranes at the laminar flow interface. These membranes were reduced with aqueous sodium formate or heat to create microflow devices that contain polymeric palladium-nanoparticle membranes. These microflow devices achieved instantaneous hydrodehalogenation of aryl chlorides, bromides, iodides, and triflates by 10-1000 ppm within a residence time of 2-8 s at 50-90 °C by using safe, nonexplosive, aqueous sodium formate to quantitatively afford the corresponding hydrodehalogenated products. Polychlorinated biphenyl (10-1000 ppm) and polybrominated biphenyl (1000 ppm) were completely decomposed under similar conditions, yielding biphenyl as a fungicidal compound. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Development of a PMMA Electrochemical Microfluidic Device for Carcinoembryonic Antigen Detection

    Science.gov (United States)

    Van Anh, Nguyen; Van Trung, Hoang; Tien, Bui Quang; Binh, Nguyen Hai; Ha, Cao Hong; Le Huy, Nguyen; Loc, Nguyen Thai; Thu, Vu Thi; Lam, Tran Dai

    2016-05-01

    In this study, a poly(methyl methacrylate) (PMMA) microfluidic device fabricated by an inexpensive CO2 laser etching system was developed for detection of carcino-embryonic antigens (CEA). The device was capable of working in continuous mode and was designed with the aid of numerical simulation. The detection of target CEA was based on immuno-assay via magnetic particles and electrochemical sensing. The as-prepared microfluidic can be used to detect CEA at the relatively low concentration of 150 pg mL-1. The device could be reused many times, since the capture and removal of magnetic particles in the assay could be manipulated by an external magnetic field. The proposed approach appears to be suitable for high-throughput and automated analysis of large biomolecules such as tumor markers and pathogens.

  4. Development of alloy-film coated dispenser cathode for terahertz vacuum electron devices application

    International Nuclear Information System (INIS)

    Barik, R.K.; Bera, A.; Raju, R.S.; Tanwar, A.K.; Baek, I.K.; Min, S.H.; Kwon, O.J.; Sattorov, M.A.; Lee, K.W.; Park, G.-S.

    2013-01-01

    High power terahertz vacuum electron devices demand high current density and uniform emission dispenser cathode. It was found that the coating of noble metals e.g., Os, Ir, and Re on the surface of tungsten dispenser cathodes enhances the emission capabilities and uniformity. Hence metal coated cathode might be the best candidate for terahertz devices applications. In this study, ternary-alloy-film cathode (2Os:2Re:1 W) and Os coated cathode have been developed and the results are presented. The cathodes made out of this alloy coating showed 1.5 times higher emission and 0.02 eV emission uniformity as compared to those of simply Os coated cathodes which can be used in terahertz devices application.

  5. Development of alloy-film coated dispenser cathode for terahertz vacuum electron devices application

    Energy Technology Data Exchange (ETDEWEB)

    Barik, R. K.; Bera, A. [School of Electrical Engineering and Computer Science, Seoul National University, Seoul (Korea, Republic of); Raju, R. S. [Central Electronics Engineering Research Institute (CEERI), Rajasthan (India); Tanwar, A. K.; Baek, I. K.; Min, S. H.; Kwon, O. J.; Sattorov, M. A. [Department of Physics and Astronomy, Center for THz-Bio Application Systems, and Seoul-Teracom Inc., Seoul National University, Seoul (Korea, Republic of); Lee, K. W. [LIG Nex1, Seoul (Korea, Republic of); Park, G.-S., E-mail: gunsik@snu.ac.kr [School of Electrical Engineering and Computer Science, Seoul National University, Seoul (Korea, Republic of); Department of Physics and Astronomy, Center for THz-Bio Application Systems, and Seoul-Teracom Inc., Seoul National University, Seoul (Korea, Republic of); Advanced Institute of Convergence Technology, Suwon-si, Gyeonggi-do (Korea, Republic of)

    2013-07-01

    High power terahertz vacuum electron devices demand high current density and uniform emission dispenser cathode. It was found that the coating of noble metals e.g., Os, Ir, and Re on the surface of tungsten dispenser cathodes enhances the emission capabilities and uniformity. Hence metal coated cathode might be the best candidate for terahertz devices applications. In this study, ternary-alloy-film cathode (2Os:2Re:1 W) and Os coated cathode have been developed and the results are presented. The cathodes made out of this alloy coating showed 1.5 times higher emission and 0.02 eV emission uniformity as compared to those of simply Os coated cathodes which can be used in terahertz devices application.

  6. Design and Development of a Bilateral Therapeutic Hand Device for Stroke Rehabilitation

    Directory of Open Access Journals (Sweden)

    Akhlaquor Rahman

    2013-12-01

    Full Text Available The major cause of disability is stroke. It is the second highest cause of death after coronary heart disease in Australia. In this paper, a post stroke therapeutic device has been designed and developed for hand motor function rehabilitation that a stroke survivor can use for bilateral movement practice. A prototype of the device was fabricated that can fully flex and extend metacarpophalangeal (MCP, proximal interphalangeal (PIP and distal interphalangeal (DIP joints of the fingers, and interphalangeal (IP, metacarpophalangeal (MCP and trapeziometacarpal (IM joints of the thumb of the left hand (impaired hand, based on movements of the right hand's (healthy hand fingers. Out of 21 degrees of freedom (DOFs of hand fingers, the prototype of the hand exoskeleton allowed fifteen degrees of freedom (DOFs, with three degrees of freedom (DOFs for each finger and three degrees of freedom (DOFs for the thumb. In addition, testing of the device on a healthy subject was conducted to validate the design requirements.

  7. Development of a large-solid-angle and multi-device detection system for elemental analysis

    International Nuclear Information System (INIS)

    Satoh, T.; Ishii, K.; Kamiya, T.; Sakai, T.; Oikawa, M.; Arakawa, K.; Matsuyama, S.; Yamazaki, H.

    2003-01-01

    A new detection apparatus for both low energy X-rays like 1 keV and back scattered protons of MeV energy was developed. The detection apparatus consists of a large-solid-angle multi-device Si detector and a data acquisition system. The detector has 45 detection devices which are arranged in the shape of a pentagonal pyramid and fully cover a sample. A micro-beam irradiates the sample through the center of the pentagonal pyramid and X-rays emitted from the sample are detected in a solid angle of about 1.0 sr. This novel detection setup has about five times higher sensitivity than a conventional micro-PIXE camera. In addition, not only X-rays but back scattered protons can be detected, since the counting rate of back scattered protons per detection device is small despite lack of a passive absorber

  8. Electrophoresis device

    Science.gov (United States)

    Rhodes, P. H.; Snyder, R. S. (Inventor)

    1982-01-01

    A device for separating cellular particles of a sample substance into fractionated streams of different cellular species includes a casing having a distribution chamber, a separation chamber, and a collection chamber. The electrode chambers are separated from the separation chamber interior by means of passages such that flow variations and membrane variations around the slotted portion of the electrode chamber do not enduce flow perturbations into the laminar buffer curtain flowing in the separation chamber. The cellular particles of the sample are separated under the influence of the electrical field and the separation chamber into streams of different cellular species. The streams of separated cells enter a partition array in the collection chamber where they are fractionated and collected.

  9. Recent Developments in p-Type Oxide Semiconductor Materials and Devices

    KAUST Repository

    Wang, Zhenwei

    2016-02-16

    The development of transparent p-type oxide semiconductors with good performance may be a true enabler for a variety of applications where transparency, power efficiency, and greater circuit complexity are needed. Such applications include transparent electronics, displays, sensors, photovoltaics, memristors, and electrochromics. Hence, here, recent developments in materials and devices based on p-type oxide semiconductors are reviewed, including ternary Cu-bearing oxides, binary copper oxides, tin monoxide, spinel oxides, and nickel oxides. The crystal and electronic structures of these materials are discussed, along with approaches to enhance valence-band dispersion to reduce effective mass and increase mobility. Strategies to reduce interfacial defects, off-state current, and material instability are suggested. Furthermore, it is shown that promising progress has been made in the performance of various types of devices based on p-type oxides. Several innovative approaches exist to fabricate transparent complementary metal oxide semiconductor (CMOS) devices, including novel device fabrication schemes and utilization of surface chemistry effects, resulting in good inverter gains. However, despite recent developments, p-type oxides still lag in performance behind their n-type counterparts, which have entered volume production in the display market. Recent successes along with the hurdles that stand in the way of commercial success of p-type oxide semiconductors are presented.

  10. Recent Developments in p-Type Oxide Semiconductor Materials and Devices

    KAUST Repository

    Wang, Zhenwei; Nayak, Pradipta K.; Caraveo-Frescas, Jesus Alfonso; Alshareef, Husam N.

    2016-01-01

    The development of transparent p-type oxide semiconductors with good performance may be a true enabler for a variety of applications where transparency, power efficiency, and greater circuit complexity are needed. Such applications include transparent electronics, displays, sensors, photovoltaics, memristors, and electrochromics. Hence, here, recent developments in materials and devices based on p-type oxide semiconductors are reviewed, including ternary Cu-bearing oxides, binary copper oxides, tin monoxide, spinel oxides, and nickel oxides. The crystal and electronic structures of these materials are discussed, along with approaches to enhance valence-band dispersion to reduce effective mass and increase mobility. Strategies to reduce interfacial defects, off-state current, and material instability are suggested. Furthermore, it is shown that promising progress has been made in the performance of various types of devices based on p-type oxides. Several innovative approaches exist to fabricate transparent complementary metal oxide semiconductor (CMOS) devices, including novel device fabrication schemes and utilization of surface chemistry effects, resulting in good inverter gains. However, despite recent developments, p-type oxides still lag in performance behind their n-type counterparts, which have entered volume production in the display market. Recent successes along with the hurdles that stand in the way of commercial success of p-type oxide semiconductors are presented.

  11. Development of a doorframe-typed swinging seedling pick-up device for automatic field transplantation

    Energy Technology Data Exchange (ETDEWEB)

    Han, H.; Mao, H.; Hu, J.; Tian, K.

    2015-07-01

    A doorframe-typed swing seedling pick-up device for automatic field transplanters was developed and evaluated in a laboratory. The device, consisting of a path manipulator and two grippers, can move the pins slowly to extract seedlings from the tray cells and return quickly to the pick-up point for the next extraction. The path manipulator was constructed with the creative design of type-Ⅱ mechanism combination in series. It consists of an oscillating guide linkage mechanism and a grooved globoidal cam mechanism. The gripper is a pincette-type mechanism using the pick-up pins to penetrate into the root mass for seedling extraction. The dynamic analysis of the designed seedling pick-up device was simulated with ADAMS software. Being the first prototype, various performance tests under local production conditions were conducted to find out the optimal machine operation parameters and transplant production conditions. As the gripper with multiple fine pins was moved by the swing pick-up device, it can effectively complete the transplanting work cycle of extracting, transferring, and discharging a seedling. The laboratory evaluation showed that the pick-up device equipped with two grippers can extract 80 seedlings/min with a 90% success and a 3% failure in discharging seedlings, using 42-day-old tomato plantlets. The quality of extracting seedlings was satisfactory. (Author)

  12. Developing an Anti-Xa-Based Anticoagulation Protocol for Patients with Percutaneous Ventricular Assist Devices.

    Science.gov (United States)

    Sieg, Adam; Mardis, B Andrew; Mardis, Caitlin R; Huber, Michelle R; New, James P; Meadows, Holly B; Cook, Jennifer L; Toole, J Matthew; Uber, Walter E

    2015-01-01

    Because of the complexities associated with anticoagulation in temporary percutaneous ventricular assist device (pVAD) recipients, a lack of standardization exists in their management. This retrospective analysis evaluates current anticoagulation practices at a single center with the aim of identifying an optimal anticoagulation strategy and protocol. Patients were divided into two cohorts based on pVAD implanted (CentriMag (Thoratec; Pleasanton, CA) / TandemHeart (CardiacAssist; Pittsburgh, PA) or Impella (Abiomed, Danvers, MA)), with each group individually analyzed for bleeding and thrombotic complications. Patients in the CentriMag/TandemHeart cohort were subdivided based on the anticoagulation monitoring strategy (activated partial thromboplastin time (aPTT) or antifactor Xa unfractionated heparin (anti-Xa) values). In the CentriMag/TandemHeart cohort, there were five patients with anticoagulation titrated based on anti-Xa values; one patient developed a device thrombosis and a major bleed, whereas another patient experienced major bleeding. Eight patients received an Impella pVAD. Seven total major bleeds in three patients and no thrombotic events were detected. Based on distinct differences between the devices, anti-Xa values, and outcomes, two protocols were created to guide anticoagulation adjustments. However, anticoagulation in patients who require pVAD support is complex with constantly evolving anticoagulation goals. The ideal level of anticoagulation should be individually determined using several coagulation laboratory parameters in concert with hemodynamic changes in the patient's clinical status, the device, and the device cannulation.

  13. Development of a method of testing irradiation devices by gamma scanning inside a research nuclear reactor

    International Nuclear Information System (INIS)

    Michel, Francois.

    1975-01-01

    A tridimensional experiment of spectrometry of an irradiation device located inside the reactor Siloe at a place shielded against spurious radiations, is exposed. The automatic scanning system that was developed, makes it possible to fully analyze in about 24 hours, the irradiation device (fuel pin, coolant and structures). The process combined with a 'pre-processing' program allows first partial results to be simultaneously obtained, more refined results being achieved during the next week, using the 'heavy processing'. The irradiation of the device is only interrupted during the compelling duty shutdown of the reactor, the evolution of the device during the successive irradiation cycles being thus followed up without pertubing said evolution. The reproducibility was studied at a local stage for testing the collimation of the detection unit (1% accuracy) and for testing the whole set 'processing measurement and computation' (5% accuracy). The sensitivity has been illustrated by detecting and measuring local singularities inside fuel (pellets), determining the detection efficiency dependence on the radial distribution of fission products and measuring nucleides inside the coolant flow (limiting value 10 -7 ). The accuracy of the method is evaluated at 5% for relative measurement of an experimental device during its in-pile lifetime and as 10% for quantitative absolute measurements [fr

  14. Graphene based integrated tandem supercapacitors fabricated directly on separators

    KAUST Repository

    Chen, Wei; Xia, Chuan; Alshareef, Husam N.

    2015-01-01

    It is of great importance to fabricate integrated supercapacitors with extended operation voltages as high energy density storage devices. In this work, we develop a novel direct electrode deposition on separator (DEDS) process to fabricate graphene

  15. Development of the down-ender and the spent fuel rod cutting device

    International Nuclear Information System (INIS)

    Kim, S. H.; Yoon, Ji Sup; Kim, Young Hwan; Hoo, Jung Jae; Hong, Dong Hee; Kim, Do Woo

    2000-07-01

    It is necessary to disassemble the spent fuel assembly for the recycling of the PWR spent fuels. The spent fuel disassembling process includes transportation and handling of the spent fuel assembly, extraction and cutting of the spent fuel rods, and extraction of the spent fuel pellets(decladding). In this study, the downender of the spent fuel assembly and the spent fuel rod cutting device have been developed. The downender is used to change the posture of the spent fuel assembly from the vertical to the horizontal directions, prior to extracting the fuel rods. The concepts of the remote operation and maintenance has been introduced in the design of the downender. Also, the several design consideration has been given such as the reliable adaptation of the vertically accessing the assembly to the device, the minimization of the shock force when settling down the assembly, and the interface with the rod extraction device without intermittent operation. The spent fuel rod cutting device using a tube cutter is developed for cutting the fuel rods to the suitable size. In designing this device, the mechanical property of the spent fuel rod is examined such as the strength of the clad material and the optimal size of the rod for the extracting process. Also, several cutting methods, which are commercially available, are investigated and tested in terms of the durability, the deformation on the cutting surface of the rods, and the amount of the generated debris, and the fire risk. As like the downender, the design of this device accommodates the concepts of the remote operation and maintenance

  16. Development of an isotropic underwater device for color enhancement of gemstones

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Paulo S.; Fernandes, Vagner; Enokihara, Cyro T.; Calvo, Wilson A.P.; Vasquez, Pablo A.S., E-mail: pavsalva@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    Over the past years a small-scale Gamma Irradiation Facility of the Nuclear and Energy Research Institute - IPEN has been provided services for color enhancement of Brazilian gemstones. Traditionally the gemstones are placed inside of closed screen steel bags, and then suspended deep inside the water pool by fixed steel cables in front of the Cobalt-60 sources. The processing of this material usually was performed every weekend when the facility was not operating to avoid problems related to the sources movement. The gemstones underwater irradiation is preferred among other reasons because increase their color stability and homogeneity. A hollow cylindrical device, length of 46 cm and external diameter of 38 cm built in perforated aluminum was developed to house approximately 25.0 kg (38.0 l.) of selected standard size quartz gemstones before the final cutting. The cylindrical device was constructed using defined size in order to fit a smaller cylindrical castle placed on the bottom of the pool containing 22 aligned linear radioactive sources totalizing 6.81x10{sup 2} TBq (1.84x10{sup 4} Ci). A mechanical winch fixed in an aluminum holder together with stainless steel cable and quick lock carabiners were used to descend in safety the loaded cylindrical device until to engage the device outside the smaller castle. Several dosimetric tests were performed using Harwell Red PMMA located in selected positions around the device to study the dose rate and the dose distribution. In most cases, quartz gemstones were irradiated with doses between 2 – 2.5 MGy. To achieve the desired dose values are necessary approximately 30 days of processing. One of major advantages is related to the irradiation treatment using the developed device because this does not interfere with the normal schedule operation of this facility as also the fact that is not necessary manipulate the gemstones by the end of the procedure. (author)

  17. Development of an isotropic underwater device for color enhancement of gemstones

    International Nuclear Information System (INIS)

    Santos, Paulo S.; Fernandes, Vagner; Enokihara, Cyro T.; Calvo, Wilson A.P.; Vasquez, Pablo A.S.

    2013-01-01

    Over the past years a small-scale Gamma Irradiation Facility of the Nuclear and Energy Research Institute - IPEN has been provided services for color enhancement of Brazilian gemstones. Traditionally the gemstones are placed inside of closed screen steel bags, and then suspended deep inside the water pool by fixed steel cables in front of the Cobalt-60 sources. The processing of this material usually was performed every weekend when the facility was not operating to avoid problems related to the sources movement. The gemstones underwater irradiation is preferred among other reasons because increase their color stability and homogeneity. A hollow cylindrical device, length of 46 cm and external diameter of 38 cm built in perforated aluminum was developed to house approximately 25.0 kg (38.0 l.) of selected standard size quartz gemstones before the final cutting. The cylindrical device was constructed using defined size in order to fit a smaller cylindrical castle placed on the bottom of the pool containing 22 aligned linear radioactive sources totalizing 6.81x10 2 TBq (1.84x10 4 Ci). A mechanical winch fixed in an aluminum holder together with stainless steel cable and quick lock carabiners were used to descend in safety the loaded cylindrical device until to engage the device outside the smaller castle. Several dosimetric tests were performed using Harwell Red PMMA located in selected positions around the device to study the dose rate and the dose distribution. In most cases, quartz gemstones were irradiated with doses between 2 – 2.5 MGy. To achieve the desired dose values are necessary approximately 30 days of processing. One of major advantages is related to the irradiation treatment using the developed device because this does not interfere with the normal schedule operation of this facility as also the fact that is not necessary manipulate the gemstones by the end of the procedure. (author)

  18. Analysis of lipoproteins by capillary zone electrophoresis in microfluidic devices: Assay development and surface roughness measurements

    NARCIS (Netherlands)

    Weiller, Bruce H.; Ceriotti, Laura; Shibata, Takayuki; Rein, Dietrich; Roberts, Matthew A.; Lichtenberg, Jan; German, J. Bruce; De Rooij, Nico F.; Verpoorte, Elisabeth

    2002-01-01

    The development of a new assay for lipoproteins by capillary electrophoresis in fused-silica capillaries and in glass microdevices is described in this paper. The separation of low-density (LDL) and high-density (HDL) lipoproteins by capillary zone electrophoresis is demonstrated in fused-silica

  19. Developing a new treatment device: how to get an idea to the marketplace.

    Science.gov (United States)

    Dymond, Elizabeth; Long, Adele; McCarthy, Avril; Drake, Marcus J

    2012-04-01

    A good idea does not inevitably lead to successful innovation; it needs additional "drivers" and coherent activity of a specialized team. The initial idea needs proof-of-concept and prototype testing. Alongside, market review must anticipate future need and competitors, and ensure that no current patents are infringed. The likelihood that reimbursement will be secured and that health systems will "adopt" the device has to be considered. Intellectual property (IP) protection is needed to maintain sole rights to exploit the core concept. Non-disclosure agreements (NDA) should be put in place, and commercial considerations should be remembered before any disclosure in the public domain, including publications. Prospective business partners will review the concept from many perspectives, including stage of device development, effective IP protection, any clinical trial evidence, and whether the device aligns with their business strategy. Royalties arising from sales of a marketed device are distributed to all parties contributing to its development; the party bearing the greater financial burden of developing the final product will gain the greater share of royalties. The innovator's employer will have a call on proceeds if the idea arose in the course of employment. All stages of development require fastidious documentation to meet requirements of the regulatory authorities responsible for permitting use in patients. Specific regulatory requirements depend on which region(s) of the world the device will be marketed in. This review explains all stages of the innovation pathway from concept to adoption, giving practical advice and signposting expertise relevant to each stage. Copyright © 2011 Wiley Periodicals, Inc.

  20. Brief overview of the long-lived radionuclide separation processes developed in France in connection with the SPIN program

    International Nuclear Information System (INIS)

    Madic, C.; Bourges, J.; Dozol, J.F.

    1995-01-01

    To reduce the long-term potential hazards associated with the management of nuclear wastes generated by nuclear fuel reprocessing, one alternative is the transmutation of long-lived radionuclides into short-lived radionuclides by nuclear means (P ampersand T strategy). In this context, according to the law passed by the French Parliament on 30 December 1991, the CEA launched the SPIN program for the design of long-lived radionuclide separation and nuclear incineration processes. The research in progress to define separation processes focused mainly on the minor actinides (neptunium, americium and curium) and some fission products, like cesium and technetium. To separate these long-lived radionuclides, two strategies were developed. The first involves research on new operating conditions for improving the PUREX fuel reprocessing technology. This approach concerns the elements neptunium and technetium (iodine and zirconium can also be considered). The second strategy involves the design of new processes; DIAMEX for the co-extraction of minor actinides from the high-level liquid waste leaving the PUREX process, An(III)/Ln(III) separation using tripyridyltriazine derivatives or picolinamide extracting agents; SESAME for the selective separation of americium after its oxidation to Am(IV) or Am(VI) in the presence of a heteropolytungstate ligand, and Cs extraction using a new class of extracting agents, calixarenes, which exhibit exceptional Cs separation properties, especially in the presence of sodium ion. This lecture focuses on the latest achievements in these research areas

  1. Some interesting developments relating to gas dynamics in the application of the UCOR process for isotope separation

    International Nuclear Information System (INIS)

    Alant, T.G.; Schumann, W.A.

    1980-01-01

    The separating element employed in the UCOR process for uranium enrichment has a very small cut, i.e. is highly asymmetrical with respect to the UF 6 flow in the enriched and depleted streams. For the commercial exploitation of the process, the so-called helikon technique of cascading was developed. The process is dependent on the transmission of parallel streams of diffferent isotopic composition through an axial compressor without significant mixing between them. A light gas (H 2 ), which is present in large molar excess, increases the flow velocity of the process gas (UF 6 ) and hence adds to improved separation performance. The separating element not only separates isotopes but also causes appreciable separation between the process gas and the light carrier gas. The paper consists of a brief description of the helikon cascading technique followed by a comprehensive assessment of the various aspects of gas mixing in an axial compressor. Phenomena of mole mass and pressure transients which occur in the module during run-up of the compressors are also discussed. The operating characteristics of axial compressors and of the separating element produce a driving force which tends to cause mole mass and associated pressure gradients to occur circumferentially in a helikon module under static conditions. The paper includes 5 references and 10 figures

  2. Brief overview of the long-lived radionuclide separation processes developed in france in connection with the spin program

    Science.gov (United States)

    Madic, Charles; Bourges, Jacques; Dozol, Jean-François

    1995-09-01

    To reduce the long-term potential hazards associated with the management of nuclear wastes generated by nuclear fuel reprocessing, one alternative is the transmutation of long-lived radionuclides into short-lived radionuclides by nuclear means (P & T strategy). In this context, according to the law passed by the French Parliament on 30 December 1991, the CEA launched the SPIN program for the design of long-lived radionuclide separation and nuclear incineration processes. The research in progress to define separation processes focused mainly on the minor actinides (neptunium, americium and curium) and some fission products, like cesium and technetium. To separate these long-lived radionuclides, two strategies were developed. The first involves research on new operating conditions for improving the PUREX fuel reprocessing technology. This approach concerns the elements neptunium and technetium (iodine and zirconium can also be considered). The second strategy involves the design of new processes; DIAMEX for the co-extraction of minor actinides from the high-level liquid waste leaving the PUREX process, An(III)/Ln(III) separation using tripyridyltriazine derivatives or picolinamide extracting agents; SESAME for the selective separation of americium after its oxidation to Am(IV) or Am(VI) in the presence of a heteropolytungstate ligand, and Cs extraction using a new class of extracting agents, calixarenes, which exhibit exceptional Cs separation properties, especially in the presence of sodium ion. This lecture focuses on the latest achievements in these research areas.

  3. Brief overview of the long-lived radionuclide separation processes developed in France in connection with the SPIN program

    Energy Technology Data Exchange (ETDEWEB)

    Madic, C.; Bourges, J. [DRDD, Fontenay-aux-Roses (France); Dozol, J.F. [DESD, Cadarache (France)

    1995-10-01

    To reduce the long-term potential hazards associated with the management of nuclear wastes generated by nuclear fuel reprocessing, one alternative is the transmutation of long-lived radionuclides into short-lived radionuclides by nuclear means (P & T strategy). In this context, according to the law passed by the French Parliament on 30 December 1991, the CEA launched the SPIN program for the design of long-lived radionuclide separation and nuclear incineration processes. The research in progress to define separation processes focused mainly on the minor actinides (neptunium, americium and curium) and some fission products, like cesium and technetium. To separate these long-lived radionuclides, two strategies were developed. The first involves research on new operating conditions for improving the PUREX fuel reprocessing technology. This approach concerns the elements neptunium and technetium (iodine and zirconium can also be considered). The second strategy involves the design of new processes; DIAMEX for the co-extraction of minor actinides from the high-level liquid waste leaving the PUREX process, An(III)/Ln(III) separation using tripyridyltriazine derivatives or picolinamide extracting agents; SESAME for the selective separation of americium after its oxidation to Am(IV) or Am(VI) in the presence of a heteropolytungstate ligand, and Cs extraction using a new class of extracting agents, calixarenes, which exhibit exceptional Cs separation properties, especially in the presence of sodium ion. This lecture focuses on the latest achievements in these research areas.

  4. Emergency separation of a xipho-omphalopagus twin in a developing country

    Directory of Open Access Journals (Sweden)

    Shukla R

    2010-01-01

    Full Text Available Female conjoined twins (thoraco-omphalopagus were delivered by emergency caesarean section in a private nursing home. On examination, one of the twins was dead and was threatening the survival of the surviving twin (twin A. An emergency separation was performed to salvage the surviving twin.

  5. Ionomers of intrinsic microporosity: in silico development of ionic-functionalized gas-separation membranes.

    Science.gov (United States)

    Hart, Kyle E; Colina, Coray M

    2014-10-14

    This work presents the predictive molecular simulations of a functionalized polymer of intrinsic microporosity (PIM) with an ionic backbone (carboxylate) and extra-framework counterions (Na(+)) for CO2 gas storage and separation applications. The CO2-philic carboxylate-functionalized polymers are predicted to contain similar degrees of free volume to PIM-1, with Brunauer-Emmett-Teller (BET) surface areas from 510 to 890 m(2)/g, depending on concentration of ionic groups from 100% to 17%. As a result of ionic groups enhancing the CO2 enthalpy of adsorption (to 42-50 kJ/mol), the uptake of the proposed polymers at 293 K exceeded 1.7 mmol/g at 10 kPa and 3.3 mmol/g at 100 kPa for the polymers containing 100% and 50% ionic functional groups, respectively. In addition, CO2/CH4 and CO2/N2 mixed-gas separation performance was evaluated under several industrially relevant conditions, where the IonomIMs are shown to increase both the working capacity and selection performance in certain pressure swing applications (e.g., natural gas separations). These simulations reveal that intrinsically microporous ionomers show great potential as the future of energy-efficient gas-separation polymeric materials.

  6. Development for a process for the adsorptive separation of krypton-85

    International Nuclear Information System (INIS)

    Messler, M.

    1985-03-01

    In the final process step of dissolver waste gas purification in a reprocessing facility, the radioactive noble gas Kr-85 is separated by physical separation processes. The experiments showed that the available mixture of air/Kr/Xe can be appropriately separated by chromatography. In principle, the adsorption column is laded with the waste gas and subsequently regenerated by puring with a carrier gas. A complete separation of the waste gas components can thus be achieved. He suggests itself as a purge gas. Fine-grained activated charcoals are to be preferred as adsorbing agents. Among the adsorptive process alternatives studied, one variant in which the adsorber was split into two halves and loaded at -130 0 C or -160 0 C proved to be particularly suitable. It can be seen that a total of only 0.2 m 3 of activated charcoal would be required for a commerical facility with a waste gas throughput of 100 nm 3 /h. The helium flux required only amounts to 4% of the waste gas flow to be purified. If valuable xenon is also to be recovered then this value increases to 7%. In this case the quantity of activated charcoal necessary would be 0.28 m 3 . A comparison with alternative process principles indicated that the adsorptive concept has advantages with respect to process engineering and regarding high safety standards in nuclear engineering facilities. (orig./HP) [de

  7. Instrumental development of novel detection and separation methods for capillary electrophoresis

    Energy Technology Data Exchange (ETDEWEB)

    Garner, Tommy [Iowa State Univ., Ames, IA (United States)

    1993-07-01

    After a general introduction, this thesis is divided into 3 parts: indirect fluorescence detection of sugars separated by capillary zone electrophoresis with visible laser excitation, absorption detection in capillary electrophoresis by fluorescence energy transfer, and increased selectivity for electrochromatography by dynamic ion exchange.

  8. Development of a centrifugal in-line separator for oil-water flows

    NARCIS (Netherlands)

    Slot, J.J.

    2013-01-01

    The world energy consumption will increase in the next decades. However, many aging oil fields are showing a steady decline in oil production. And they are producing increasing amounts of water, making the separation of the oil from the oil-water mixture an important processing step. In-line

  9. Development of north sea coastal plankton communities in separate plastic bags under identical conditions

    NARCIS (Netherlands)

    Kuiper, J.

    1977-01-01

    In two experiments lasting 4 to 6 weeks, communities of North Sea coastal plankton kept in separate plastic bags (of about 1400 l) and exposed to the same environmental conditions showed very similar patterns of growth and decline. This result means that the method is suitable for the evaluation of

  10. Regulation and Device Development: Tips for Optimizing Your Experience With the Food and Drug Administration.

    Science.gov (United States)

    Brooks, Steven S

    2017-06-01

    Physician-inventors are in a unique position to identify unserved patient needs, and innovate solutions to clinical problems. These solutions may also have associated commercial opportunities. The logistics of developing these medical products, however, can seem a daunting task. One of the primary barriers in the United States is the regulatory process of the Food and Drug Administration (FDA). In this article, we will explore the risk-based approach used by the FDA which forms a framework to consider the regulatory pathway and the process to gain regulatory clearance or approval for medical devices. Inherent device properties and the procedural risk of the devices will determine the rigor with which they are scrutinized by FDA, and the evidentiary requirements to legally market them. Data and evidentiary development will vary depending on risk and regulatory precedent and may or may not require clinical data This regulatory paradigm will determine into which risk-based device class they fit, and whether they are regulated under the 510(k) or premarket approval application pathways. The FDA, although gatekeeper of the US market and tasked with determining which products are safe and effective, can be a powerful ally for product development. They have significant scientific and medical expertise, and mechanisms to both provide guidance, and also to consider novel approaches to product development and evidence development. Early interaction for routine and novel products alike can result in expedited and efficient development. This collaborative approach can be best practice to most expeditiously develop the next generation of products, getting them into the hands of US doctors and into the treatment of US patients. Copyright © 2017. Published by Elsevier Inc.

  11. Technical Status Report on the Effect of Phosphate and Aluminum on the Development of Amorphous Phase Separation in Sodium

    International Nuclear Information System (INIS)

    Cozzi, A.D.

    1998-01-01

    The objective of the Tank Focus Area ''Optimize Waste Loading'' task is to enhance the definition of the acceptable processing window for high-level waste vitrification plants. One possible manner in which the acceptable processing window may be enhanced is by reducing the uncertainty of various compositional/property models through a specifically defined experimental plan. A reduction in model uncertainty can reduce limitations on current acceptance constraints and may allow for a larger processing or operational window. Enhanced composition/property model predictions coupled with an increased waste loading may decrease the processing time and waste glass disposal costs (i.e., overall lifecycle costs). One of the compositional/property models currently being evaluated by the Tanks Focus Area is related to the development of amorphous phase separation in multi-component borosilicate glasses.Described in this report is the current status for evaluating the effect of phosphorus and alumina on both simple sodium borosilicate and high-level waste glasses on the formation of amorphous phase separation. The goal of this subtask is to increase the understanding of the formation of phase separation by adding significant amounts (3-5 wt. percent) of phosphorus and alumina to well-characterized glasses. Additional scope includes evaluating the effects of thermal history on the formation of amorphous phase separation and durability of select glasses.The development of data, understanding, and quantitative description for composition and kinetic effects on the development of amorphous phase separation will continue in FY99. This effort will provide insight into the compositional and thermal effects on phase stability and will lead to a better understanding of the methods used to predict the development of amorphous phase separation in HLW glasses

  12. Acoustofluidic bacteria separation

    International Nuclear Information System (INIS)

    Li, Sixing; Huang, Tony Jun; Ma, Fen; Zeng, Xiangqun; Bachman, Hunter; Cameron, Craig E

    2017-01-01

    Bacterial separation from human blood samples can help with the identification of pathogenic bacteria for sepsis diagnosis. In this work, we report an acoustofluidic device for label-free bacterial separation from human blood samples. In particular, we exploit the acoustic radiation force generated from a tilted-angle standing surface acoustic wave (taSSAW) field to separate Escherichia coli from human blood cells based on their size difference. Flow cytometry analysis of the E. coli separated from red blood cells shows a purity of more than 96%. Moreover, the label-free electrochemical detection of the separated E. coli displays reduced non-specific signals due to the removal of blood cells. Our acoustofluidic bacterial separation platform has advantages such as label-free separation, high biocompatibility, flexibility, low cost, miniaturization, automation, and ease of in-line integration. The platform can be incorporated with an on-chip sensor to realize a point-of-care sepsis diagnostic device. (paper)

  13. Acoustofluidic bacteria separation

    Science.gov (United States)

    Li, Sixing; Ma, Fen; Bachman, Hunter; Cameron, Craig E.; Zeng, Xiangqun; Huang, Tony Jun

    2017-01-01

    Bacterial separation from human blood samples can help with the identification of pathogenic bacteria for sepsis diagnosis. In this work, we report an acoustofluidic device for label-free bacterial separation from human blood samples. In particular, we exploit the acoustic radiation force generated from a tilted-angle standing surface acoustic wave (taSSAW) field to separate Escherichia coli from human blood cells based on their size difference. Flow cytometry analysis of the E. coli separated from red blood cells shows a purity of more than 96%. Moreover, the label-free electrochemical detection of the separated E. coli displays reduced non-specific signals due to the removal of blood cells. Our acoustofluidic bacterial separation platform has advantages such as label-free separation, high biocompatibility, flexibility, low cost, miniaturization, automation, and ease of in-line integration. The platform can be incorporated with an on-chip sensor to realize a point-of-care sepsis diagnostic device.

  14. Development and validation of a noncontact spectroscopic device for hemoglobin estimation at point-of-care

    Science.gov (United States)

    Sarkar, Probir Kumar; Pal, Sanchari; Polley, Nabarun; Aich, Rajarshi; Adhikari, Aniruddha; Halder, Animesh; Chakrabarti, Subhananda; Chakrabarti, Prantar; Pal, Samir Kumar

    2017-05-01

    Anemia severely and adversely affects human health and socioeconomic development. Measuring hemoglobin with the minimal involvement of human and financial resources has always been challenging. We describe a translational spectroscopic technique for noncontact hemoglobin measurement at low-resource point-of-care settings in human subjects, independent of their skin color, age, and sex, by measuring the optical spectrum of the blood flowing in the vascular bed of the bulbar conjunctiva. We developed software on the LabVIEW platform for automatic data acquisition and interpretation by nonexperts. The device is calibrated by comparing the differential absorbance of light of wavelength 576 and 600 nm with the clinical hemoglobin level of the subject. Our proposed method is consistent with the results obtained using the current gold standard, the automated hematology analyzer. The proposed noncontact optical device for hemoglobin estimation is highly efficient, inexpensive, feasible, and extremely useful in low-resource point-of-care settings. The device output correlates with the different degrees of anemia with absolute and trending accuracy similar to those of widely used invasive methods. Moreover, the device can instantaneously transmit the generated report to a medical expert through e-mail, text messaging, or mobile apps.

  15. Superhydrophobic paper in the development of disposable labware and lab-on-paper devices.

    Science.gov (United States)

    Sousa, Maria Peixoto; Mano, João Filipe

    2013-05-01

    Traditionally in superhydrophobic surfaces history, the focus has frequently settled on the use of complex processing methodologies using nonbiodegradable and costly materials. In light of recent events on lab-on-paper emergence, there are now some efforts for the production of superhydrophobic paper but still with little development and confined to the fabrication of flat devices. This work gives a new look at the range of possible applications of bioinspired superhydrophobic paper-based substrates, obtained using a straightforward surface modification with poly(hydroxybutyrate). As an end-of-proof of the possibility to create lab-on-chip portable devices, the patterning of superhydrophobic paper with different wettable shapes is shown with low-cost approaches. Furthermore, we suggest the use of superhydrophobic paper as an extremely low-cost material to design essential nonplanar lab apparatus, including reservoirs for liquid storage and manipulation, funnels, tips for pipettes, or accordion-shaped substrates for liquid transport or mixing. Such devices take the advantage of the self-cleaning and extremely water resistance properties of the surfaces as well as the actions that may be done with paper such as cut, glue, write, fold, warp, or burn. The obtained substrates showed lower propensity to adsorb proteins than the original paper, kept superhydrophobic character upon ethylene oxide sterilization and are disposable, suggesting that the developing devices could be especially adequate for use in contact with biological and hazardous materials.

  16. Development of Carbotrap B-packed needle trap device for determination of volatile organic compounds in air.

    Science.gov (United States)

    Poormohammadi, Ali; Bahrami, Abdulrahman; Farhadian, Maryam; Ghorbani Shahna, Farshid; Ghiasvand, Alireza

    2017-12-08

    Carbotrap B as a highly pure surface sorbent with excellent adsorption/desorption properties was packed into a stainless steel needle to develop a new needle trap device (NTD). The performance of the prepared NTD was investigated for sampling, pre-concentration and injection of benzene, toluene, ethyl benzene, o-xylene, and p-xylene (BTEX) into the column of gas chromatography-mass spectrometry (GC-MS) device. Response surface methodology (RSM) with central composite design (CCD) was also employed in two separate consecutive steps to optimize the sampling and device parameters. First, the sampling parameters such as sampling temperature and relative humidity were optimized. Afterwards, the RSM was used for optimizing the desorption parameters including desorption temperature and time. The results indicated that the peak area responses of the analytes of interest decreased with increasing sampling temperature and relative humidity. The optimum values of desorption temperature were in the range 265-273°C, and desorption time were in the range 3.4-3.8min. The limits of detection (LODs) and limits of quantitation (LOQs) of the studied analytes were found over the range of 0.03-0.04ng/mL, and 0.1-0.13ng/mL, respectively. These results demonstrated that the NTD packed with Carbotrap B offers a high sensitive procedure for sampling and analysis of BTEX in concentration range of 0.03-25ng/mL in air. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Development and use of thin film composite based positively charged nanofiltration membranes in separation of aqueous streams and nuclear effluents

    International Nuclear Information System (INIS)

    Dey, T.K.; Bindal, R.C.; Prabhakar, S.; Tewari, P.K.

    2010-01-01

    A new, positively charged, thin film composite (TFC) type nanofiltration membrane has been developed and studied for its use in various aqueous stream separations. The membrane, containing fixed quaternary ammonium moieties, was developed by insitu interfacial polymerization of a functionalized amine (polyethyleneimine) and terephthaloyl chloride on a suitable base membrane. The nature of the charge on the membrane was established by ATR FT IR spectroscopy and was estimated by determination of its ion exchange capacity. The membrane was tested for its performance in single solute feed systems containing salts of various combinations of univalent and bivalent ions (NaCl, Na 2 SO 4 , CaCl 2 and MgSO 4 ) in test cell as well as in 2512 spiral modules. The membrane gave differential separation profile for these solutes with high rejection for CaCl 2 and low rejection for Na 2 SO 4 due to positive charge on the membrane and the type of charge constituting the salts. The membrane was also used for separation of simulated effluent solution containing uranyl nitrate in combination with ammonium nitrate which is a common effluent generated in nuclear industry. Here also the membrane gave differential separation profile for uranyl nitrate and ammonium nitrate in their mixture by concentrating the former salt and passing the later. This helped separation of these two solutes in the mixture into two different streams. (author)

  18. The multiple gas-liquid subsea separation system: development and qualification of a novel solution for deep water field production

    Energy Technology Data Exchange (ETDEWEB)

    Abrand, Stephanie; Butin, Nicolas; Shaiek, Sadia; Hallot, Raymond [Saipem S.p.A., Milano (Italy)

    2012-07-01

    Subsea processing is more and more considered as a viable solution for the development of deep and ultra deep water fields. SAIPEM has developed a deep water gas separation and liquid boosting system, based on its proprietary 'Multi pipe' separator concept, providing a good flexibility in handling a wide range of steady and un-steady multiphase input streams using a relatively simple mechanical arrangement. The Multi pipe Concept features an array of vertical pipes for gas/liquid separation by gravity and adequate liquid hold up volumes. The operating principle is the same as standard gravity vessels. Specific inlet pipe arrangements have been worked out to enhance the separation efficiency and internals can be implemented to further optimize the performances. The limited diameter and wall thickness of the vertical pipes make the Multi pipe Concept particularly suited for deep and ultra-deep water applications and/or high pressure conditions where the selection of a single separator vessel could lead to unpractical wall thicknesses. In most cases, standard API or ASME pipes can be utilized for the Multi pipe Separator, thus enabling conventional fabrication methods, and in turn reducing cost and delivery time and opening opportunities for local content. The qualification testing program has seen two subsequent phases. The first qualification phase aimed at the confirmation of the hydrodynamic behavior of the system. In particular, the homogeneous distribution of the multiphase stream into the pipes and the stability of the liquid levels under un-steady inlet conditions were continuously assessed during the tests. This first qualification phase gave confidence in the viability of the Multi pipe and in its good hydrodynamic behavior under the different inlet conditions that can be encountered during field production. It proved that, having the same liquid level in all the separator pipes, whatever the inlet conditions are, the Multi pipe separator can be

  19. Development of a Device for a Material Irradiation Test in the OR Test Hole

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Man Soon; Kang, Y. H.; Kim, B. G.; Choo, K. N.; Sohn, J. M.; Shin, Y. T.; Park, S. J.; Seo, C. K

    2008-05-15

    To develop a technology and a device for the irradiation test for utilization of the OR/IP holes according to the various requirements of users, the properties of the OR/IP holes were investigated and an irradiation device for the OR hole was designed and fabricated. The OR-4, 5 and the IP-9, 10, 11 holes were selected as those suitable to irradiation tests among the test holes located in the out core area. The conceptual design was performed to design a device to irradiate materials using the OR and IP holes. The capsule for the OR holes is fixed by pressing the protection tube using a clamping device, on the other hand the IP capsule is inserted in the hole without a special clamping device. In the basic design of the irradiation device for the OR hole, the capsules having the outside diameter of 50, 52, 54, 56mm were reviewed theoretically to investigate if they meet the hydraulic and vibration conditions required in the HANARO. The results of the pressure drop test showed that the 3 kinds of capsules having diameter of 52, 54, 56mm satisfied the requirement for the pressure difference and flow rate in HANARO. The capsule of {phi}56mm out of the above three satisfied the vibration condition and was finally selected giving consideration of a capacity of specimens. The capsule having a diameter of {phi}56mm was fabricated and the flow rate was measured. Using the velocity data measured at the out-core facility, the heat transfer coefficient, and the temperature on the surface of the capsule was evaluated to confirm it less than the ONB temperature. As a result, the capsule of {phi}56mm was selected for the irradiation test at the OR holes.

  20. SU-E-J-48: Development of An Abdominal Compression Device for Respiratory Correlated Radiation Therapy

    International Nuclear Information System (INIS)

    Kim, T; Kang, S; Kim, D; Suh, T; Kim, S

    2014-01-01

    Purpose: The aim of this study is to develop the abdominal compression device which could control pressure level according to the abdominal respiratory motion and evaluate its feasibility. Methods: In this study, we focused on developing the abdominal compression device which could control pressure level at any point of time so the developed device is possible to use a variety of purpose (gating technique or respiratory training system) while maintaining the merit of the existing commercial device. The compression device (air pad form) was designed to be able to compress the front and side of abdomen and the pressure level of the abdomen is controlled by air flow. Pressure level of abdomen (air flow) was determined using correlation data between external abdominal motion and respiratory volume signal measured by spirometer. In order to verify the feasibility of the device, it was necessary to confirm the correlation between the abdominal respiratory motion and respiratory volume signal and cooperation with respiratory training system also checked. Results: In the previous study, we could find that the correlation coefficient ratio between diaphragm and respiratory volume signal measured by spirometer was 0.95. In this study, we confirmed the correlation between the respiratory volume signal and the external abdominal motion measured by belt-transducer (correlation coefficient ratio was 0.92) and used the correlated respiratory volume data as an abdominal pressure level. It was possible to control the pressure level with negligible time delay and respiratory volume data based guiding waveforms could be properly inserted into the respiratory training system. Conclusion: Through this feasibility study, we confirmed the correlation between the respiratory volume signal and the external abdominal motion. Also initial assessment of the device and its compatibility with the respiratory training system were verified. Further study on application in respiratory gated

  1. Fusion Engineering Device. Volume VI. Complementary development plan for engineering development

    International Nuclear Information System (INIS)

    1981-10-01

    The basic approach followed in this volume is to define key technical issues for several fusion reactor technologies and to device program strategies to resolve each of these issues. Particular attention has been paid to elucidating the role of FED vis-a-vis complementary (non-FED) facilities in this process. The remainder of this chapter consists of summaries of the major conclusions of the technology plans in each of the areas studied, i.e., plasma heating, magnetics, nuclear, and systems considerations

  2. Pilot plant development for adsorptive krypton separation from dissolver off-gas

    International Nuclear Information System (INIS)

    Ringel, H.; Printz, R.

    1987-01-01

    In view of hot cell application a separation process was investigated for the retention of Kr-85 from gaseous effluents. In the flow sheet only adsorption beds are applied. The most efficient process scheme is adsorption of the noble gas on activated charcoal and thereafter separation of the coadsorbed gas species like N 2 , O 2 , Xe and CO 2 from the krypton by gas chromatography. Adsorption is at normal pressure and low temperatures of up to -160 0 C, whereas desorption is at elevated temperatures and under helium purge. Influences on the process operation like off-gas composition, adsorption temperatures and adsorbent are experimentally investigated, as well as the behavior of trace impurities in the adsorption columns. On the basis of pilot plant operation the main components for a full scale facility are being designed

  3. Development of bufferless gel electrophoresis chip for easy preparation and rapid DNA separation.

    Science.gov (United States)

    Oleksandrov, Sergiy; Aman, Abdurazak; Lim, Wanyoung; Kim, Younghee; Bae, Nam Ho; Lee, Kyoung G; Lee, Seok Jae; Park, Sungsu

    2018-02-01

    This work presents a handy, fast, and compact bufferless gel electrophoresis chip (BGEC), which consists of precast agarose gel confined in a disposable plastic body with electrodes. It does not require large volumes of buffer to fill reservoirs, or the process of immersing the gel in the buffer. It withstands voltages up to 28.4 V/cm, thereby allowing DNA separation within 10 min with a similar separation capability to the standard gel electrophoresis. The results suggest that our BGEC is highly suitable for in situ gel electrophoresis in forensic, epidemiological settings and crime scenes where standard gel electrophoresis equipment cannot be brought in while quick results are needed. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Development of the high temperature ion-source for the Grenoble electromagnetic isotope separator

    International Nuclear Information System (INIS)

    Bouriant, M.

    1968-01-01

    The production of high purity stable or radioactive isotopes (≥ 99.99 per cent) using electromagnetic separation require for equipment having a high resolving power. Besides, and in order to collect rare or short half-life isotopes, the efficiency of the ion-source must be high (η > 5 to 10 per cent). With this in view, the source built operates at high temperatures (2500-3000 C) and makes use of ionisation by electronic bombardment or of thermo-ionisation. A summary is given in the first part of this work on the essential characteristics of the isotope separator ion Sources; a diagram of the principle of the source built is then given together with its characteristics. In the second part are given the values of the resolving power and of the efficiency of the Grenoble isotope separator fitted with such a source. The resolving power measured at 10 per cent of the peak height is of the order of 200. At the first magnetic stage the efficiency is between 1 and 26 per cent for a range of elements evaporating between 200 and 3000 C. Thus equipped, the separator has for example given, at the first stage, 10 mg of 180 Hf at (99.69 ± 0.1) per cent corresponding to an enrichment coefficient of 580; recently 2 mg of 150 Nd at (99.996 ± 0.002) per cent corresponding to an enrichment coefficient of 4.2 x 10 5 has been obtained at the second stage. (author) [fr

  5. Development of polysulfonic composite beads for extraction and separation of rare earths

    International Nuclear Information System (INIS)

    Yadav, K.K.; Singh, D.K.; Singh, H.; Varshney, L.

    2012-01-01

    Solvent extraction technology has been extensively applied to the practical separation of rare earth metals. Among the extractants commonly employed at present, di(2-ethylhexyl) hydrogen phosphate (D2EHPA) and 2-ethylhexyl hydrogen 2-ethylhexylphosphonate (PC-88A) are known to have advantages of high separation efficiency for rate earth metals and of low solubility in water. However, separation via solvent extraction requires multistage cycles of extraction and back extraction in order to attain favorable separation. Novel adsorbents such as solvent impregnated resins (SIRS), metal-imprinted polymers and microcapsules containing extractants might have wide applicability due to their characteristics having respective advantages of solvent extraction and the ion-exchange technique. In the present work, polymeric composite material impregnating extractants such as D2EHPA, PC88A and DNPPA were prepared and tested for rare earths recovery from chloride medium. Exploratory tests were conducted with Yttrium (taking as representative of rare earths) to evaluate the suitability of the composite beads having D2EHPA, PC88A and DNPPA. Preparation of beads comprises of following steps. Initially, a polymer solutions containing suitable amount of polymer (5 to 15% with 1% water soluble additive) in N-methyl pyrrolidone (NMP) was prepared. The above prepared solutions were then mixed with organophosphorus type of extractant namely D2EHPA, PC88A and di nonyl phenyl phosphoric acid (DNPPA). This polymer solution was gradually dropped drop wise into the water bath through a syringe needle. In the preparation, the temperature of the water was kept constant using a thermostatic unit. As as polymeric drop comes in contact with water due to phase inversion, polysulfonic microcapsules impregnated with the extractant were obtained, these microcapsules were immersed and stabilized in the water bath for 24 h

  6. Retraction of “Accurate Prediction of Essential Fundamental Properties for Semiconductors Used in Solar-Energy Conversion Devices from Range-Separated Hybrid Density Functional Theory”

    KAUST Repository

    Harb, Moussab

    2016-01-01

    The author retracts this article due to similarities with a previously published article by Le Bahers, T.; Rerat, M.; Sautet, ́ P. Semiconductors Used in Photovoltaic and Photocatalytic Devices: Assessing Fundamental Properties from DFT. J. Phys

  7. Ion source development for the on-line isotope separator at GSI

    International Nuclear Information System (INIS)

    Kirchner, R.; Burkard, K.; Hueller, W.; Klepper, O.

    1991-08-01

    The progress in the understanding of ion sources for isotope separation on-line and the feasibility of bunched beams of relatively refractory elements is reported. The ultra-high temperature FEBIAD-H ion source, facilitating the mounting of catchers and window compared to the earlier F-version, enables bunched beams of the elements with adsorption enthalpies up to almost 6 eV, e.g. of Be, Al, Ca, Cr, Fe, Co, Ni, Sr, Pd, Ba, Yb, and Au. This way also chemical selectivity for these elements may be achieved, at least to some extent, for isotopes with halflives > or approx.1 minute, including especially the difficult separation of alkaline-earth isotopes from isobaric alkalines. These studies reveal, however, also a principal difficulty in the on-line separation of refractory elements, namely their tendency, increasing with ΔH a , to re-diffuse after release from the catcher into the bulk of the hot source enclosure. (orig.)

  8. DEVELOPMENT OF THE LOAD MEASURING DEVICES TO DETERMINE THE RESIDUAL DEFORMATION OF THE ELASTIC SENSING ELEMENT

    Directory of Open Access Journals (Sweden)

    Ivan V. Antonets

    2018-01-01

    Full Text Available The main focus in the design of weighing and batching devices is to create a gravimetric technique, capable of providing not only mass measurement – weighing with the required accuracy and speed, but also automatic control of technological processes and their control and regulation. In this case, the opportunity of two-way communication with a computer when designing the load measuring devices is realized, allowing remote monitoring and solution of logical problems associated with the management process. Modern automatic weighing and batching devices are important parts of comprehensive automation in different branches of industry. Existing developments of electrical, electronic, computing and other branches of instrument engineering techniques allow to implement transformations of the measured quantity with a very high degree of accuracy. However, if the measured quantity in the weighing process is perceived by the elastic sensing element of low quality, then no matter how high the accuracy of further changes is; the characteristics of the elastic element will limit the accuracy of the instrument as a whole. Although the elastic elements are simple mechanical parts, and many types of elastic elements are known and are widely used for many decades, their performance often does not meet the requirements, and hampers the device creation of high accuracy classes. Growing requirements for primary transformer makes actual the problem solution of improving the quality of elastic sensing elements not only in the manufacture but in the design. This led to the appearance of projects aimed at the development of computational and experimental methods that have altered the methodology for the design of force measuring devices.

  9. Development of Novel active transport membrane devices. Phase I. Final report, 31 October 1988--31 January 1994

    Energy Technology Data Exchange (ETDEWEB)

    Laciak, D.V.; Quinn, R.; Choe, G.S.; Cook, P.J.; Tsai, Fu-Jya

    1994-08-01

    The main objective of this program was to identify and develop a technique for fabricating Active Transport Materials (ATM) into lab-scale membrane devices. Air Products met this objective by applying thin film, multilayer fabrication techniques to support the AT material on a substrate membrane. In Phase IA, spiral-wound hollow fiber membrane modules were fabricated and evaluated. These nonoptimized devices were used to demonstrate the AT-based separation of carbon dioxide from methane, hydrogen sulfide from methane, and ammonia from hydrogen. It was determined that a need exists for a more cost efficient and less energy intensive process for upgrading subquality natural gas. Air Products estimated the effectiveness of ATM for this application and concluded that an optimized ATM system could compete effectively with both conventional acid gas scrubbing technology and current membrane technology. In addition, the optimized ATM system would have lower methane loss and consume less energy than current alternative processes. Air Products made significant progress toward the ultimate goal of commercializing an advanced membrane for upgrading subquality natural gas. The laboratory program focused on developing a high performance hollow fiber substrate and fabricating and evaluating ATM-coated lab-scale hollow fiber membrane modules. Selection criteria for hollow fiber composite membrane supports were developed and used to evaluate candidate polymer compositions. A poly(amide-imide), PAI, was identified for further study. Conditions were identified which produced microporous PAI support membrane with tunable surface porosity in the range 100-1000{Angstrom}. The support fibers exhibited good hydrocarbon resistance and acceptable tensile strength though a higher elongation may ultimately be desirable. ATM materials were coated onto commercial and PAI substrate fiber. Modules containing 1-50 fibers were evaluated for permselectivity, pressure stability, and lifetime.

  10. Development of a 6 DOF force-reflecting master input device

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Ji Sup; Yoon, Ho Sik

    1999-05-01

    The teleoperator is a very effective tool for various tasks of nuclear application in that it can reduce the operators' exposure to the radiation. For the utmost performances of the teleoperator, the force reflection capability is essential. This capability represents a function of transmitting the contact force of teleoperator with the object to the human operator. With this function the human operator in the remote area can effectively guide the motion of the teleoperator so that it can follow a safety guaranteed path. In this research a fully force reflectible input device 96 axis is developed. To develop the force reflecting device, the state of art is surveyed. Based on this survey, the 6 DOF manipulator which controls a power manipulator is fabricated and its performance is investigated. Also, various force reflection algorithms analyzed and the enhanced algorithm is proposed. (author). 18 refs., 4 tabs., 26 fi0008.

  11. Development of a 6 DOF force-reflecting master input device

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Ji Sup; Yoon, Ho Sik

    1999-05-01

    The teleoperator is a very effective tool for various tasks of nuclear application in that it can reduce the operators' exposure to the radiation. For the utmost performances of the teleoperator, the force reflection capability is essential. This capability represents a function of transmitting the contact force of teleoperator with the object to the human operator. With this function the human operator in the remote area can effectively guide the motion of the teleoperator so that it can follow a safety guaranteed path. In this research a fully force reflectible input device 96 axis is developed. To develop the force reflecting device, the state of art is surveyed. Based on this survey, the 6 DOF manipulator which controls a power manipulator is fabricated and its performance is investigated. Also, various force reflection algorithms analyzed and the enhanced algorithm is proposed. (author). 18 refs., 4 tabs., 26 fi0008.

  12. Development of a 6 DOF force-reflecting master input device

    International Nuclear Information System (INIS)

    Yoon, Ji Sup; Yoon, Ho Sik

    1999-05-01

    The teleoperator is a very effective tool for various tasks of nuclear application in that it can reduce the operators' exposure to the radiation. For the utmost performances of the teleoperator, the force reflection capability is essential. This capability represents a function of transmitting the contact force of teleoperator with the object to the human operator. With this function the human operator in the remote area can effectively guide the motion of the teleoperator so that it can follow a safety guaranteed path. In this research a fully force reflectible input device 96 axis) is developed. To develop the force reflecting device, the state of art is surveyed. Based on this survey, the 6 DOF manipulator which controls a power manipulator is fabricated and its performance is investigated. Also, various force reflection algorithms analyzed and the enhanced algorithm is proposed. (author). 18 refs., 4 tabs., 26 figs

  13. Development of a Nondestructive Impulse Device and Damage Model for Unreinforced Concrete

    Directory of Open Access Journals (Sweden)

    Shane D. Boone

    2012-01-01

    Full Text Available Unconstrained compression waves were measured using a newly developed, nondestructive, short impulse excitation device developed for long-term structural health monitoring. The measurements, using this innovative device, were used to determine the variation in the first longitudinal modal frequency as a function of loading magnitude and loading cycles to failure of various concrete mixes. Longitudinal frequency and cumulative energy variations were found to be a function of concrete compressive strength. These results imply that higher-strength concrete more easily absorbs energy and restricts the growth of microcracks. Based on the results, a new damage model is proposed that was shown to correlate with measured values to within 7%. This proposed model was found to have a closer correlation than Miner’s hypothesis and damage index models from other reviewed research.

  14. Aloe vera in active and passive regions of electronic devices towards a sustainable development

    Science.gov (United States)

    Lim, Zhe Xi; Sreenivasan, Sasidharan; Wong, Yew Hoong; Cheong, Kuan Yew

    2017-07-01

    The increasing awareness towards sustainable development of electronics has driven the search for natural bio-organic materials in place of conventional electronic materials. The concept of using natural bio-organic materials in electronics provides not only an effective solution to address global electronic waste crisis, but also a compelling template for sustainable electronics manufacturing. This paper attempts to provide an overview of using Aloe vera gel as a natural bio-organic material for various electronic applications. Important concepts such as responses of living Aloe vera plant towards electrical stimuli and demonstrations of Aloe vera films as passive and active regions of electronic devices are highlighted in chronological order. The biodegradability and biocompatibility of Aloe vera can bring the world a step closer towards the ultimate goal of sustainable development of electronic devices from "all-natural" materials.

  15. The Structural Engineering Strategy for Photonic Material Research and Device Development

    Directory of Open Access Journals (Sweden)

    Yalin Lu

    2007-01-01

    Full Text Available A new structural engineering strategy is introduced for optimizing the fabrication of arrayed nanorod materials, optimizing superlattice structures for realizing a strong coupling, and directly developing nanophotonic devices. The strategy can be regarded as “combinatorial” because of the high efficiency in optimizing structures. In this article, this strategy was applied to grow ZnO nanorod arrays, and to develop a new multifunctional photodetector using such nanorod arrays, which is able to simultaneously detect power, energy, and polarization of an incident ultraviolet radiation. The strategy was also used to study the extraordinary dielectric behavior of relaxor ferroelectric lead titanate doped lead magnesium niobate heterophase superlattices in the terahertz frequencies, in order to investigate their dielectric polariton physics and the potential to be integrated with tunable surface resonant plasmonics devices.

  16. Simulation codes of chemical separation process of spent fuel reprocessing. Tool for process development and safety research

    International Nuclear Information System (INIS)

    Asakura, Toshihide; Sato, Makoto; Matsumura, Masakazu; Morita, Yasuji

    2005-01-01

    This paper reviews the succeeding development and utilization of Extraction System Simulation Code for Advanced Reprocessing (ESSCAR). From the viewpoint of development, more tests with spent fuel and calculations should be performed with better understanding of the physico-chemical phenomena in a separation process. From the viewpoint of process safety research on fuel cycle facilities, it is important to know the process behavior of a key substance; being highly reactive but existing only trace amount. (author)

  17. Design and Development of Gas-Liquid Cylindrical Cyclone Compact Separators for Three-Phase Flow; SEMIANNUAL

    International Nuclear Information System (INIS)

    Mohan, Ram S.; Shoham, Ovadia

    1999-01-01

    The objective of this five-year project (October, 1997-September, 2002) is to expand the current research activities of Tulsa University Separation Technology Projects (TUSTP) to multiphase oil/water/gas separation. This project will be executed in two phases. Phase I (1997-2000) will focus on the investigations of the complex multiphase hydrodynamic flow behavior in a three-phase Gas-Liquid Cylindrical Cyclone (GLCC) Separator. The activities of this phase will include the development of a mechanistic model, a computational fluid dynamics (CFD) simulator, and detailed experimentation on the three-phase GLCC. The experimental and CFD simulation results will be suitably integrated with the mechanistic model. In Phase II (2000-2002), the developed GLCC separator will be tested under high pressure and real crudes conditions. This is crucial for validating the GLCC design for field application and facilitating easy and rapid technology deployment. Design criteria for industrial applications will be developed based on these results and will be incorporated into the mechanistic model by TUSTP

  18. Development of software-hardware complex for investigation of the vector field of speeds in the cyclone-separator

    Science.gov (United States)

    Borisov, A.

    2018-05-01

    The current issue of studying the vector velocity field in a cyclone-separator with a screw insert is considered in the article. Modeling of the velocity vector field in SolidWorks was carried out, tangential, axial and radial velocities were investigated. Also, a software and hardware complex was developed that makes it possible to obtain data on the speed inside a cyclone separator. The results of the experiment showed that on flour dusts the efficiency of the cyclone separator in question was more than 99.5%, with an air flow rate of 376 m3 / h, 472 m3 / h and 516 m3 / h, and ΔP less than 600 Pa. The velocity in the inlet branch of the screw insert was 18-20 m / s, and at the exit of the screw insert the airflow velocity is 50-70 m / s.

  19. Development of a new water sterilization device with a 365 nm UV-LED.

    Science.gov (United States)

    Mori, Mirei; Hamamoto, Akiko; Takahashi, Akira; Nakano, Masayuki; Wakikawa, Noriko; Tachibana, Satoko; Ikehara, Toshitaka; Nakaya, Yutaka; Akutagawa, Masatake; Kinouchi, Yohsuke

    2007-12-01

    Ultraviolet (UV) irradiation is an effective disinfection method. In sterilization equipment, a low-pressure mercury lamp emitting an effective germicidal UVC (254 nm) is used as the light source. However, the lamp, which contains mercury, must be disposed of at the end of its lifetime or following damage due to physical shock or vibration. We investigated the suitability of an ultraviolet light-emitting diode at an output wavelength of 365 nm (UVA-LED) as a sterilization device, comparing with the other wavelength irradiation such as 254 nm (a low-pressure mercury lam) and 405 nm (LED). We used a commercially available UVA-LED that emitted light at the shortest wavelength and at the highest output energy. The new sterilization system using the UVA-LED was able to inactivate bacteria, such as Escherichia coli DH5 alpha, Enteropathogenic E. coli, Vibrio parahaemolyticus, Staphylococcus aureus, and Salmonella enterica serovar Enteritidis. The inactivations of the bacteria were dependent on the accumulation of UVA irradiation. Taking advantage of the safety and compact size of LED devices, we expect that the UVA-LED sterilization device can be developed as a new type of water sterilization device.

  20. Development of a tapping device: a new needle insertion method for prostate brachytherapy

    International Nuclear Information System (INIS)

    Lagerburg, V; Moerland, M A; Konings, M K; Vosse, R E van de; Lagendijk, J J W; Battermann, J J

    2006-01-01

    The purpose of this study is to develop and test a tapping device for needle insertion for prostate brachytherapy. This device will tap the needle into the prostate with a certain, well-defined, amount of momentum, instead of the currently used method of pushing the needle. Because of the high needle insertion velocity, we expect prostate motion and deformation to be less compared to current methods. We measured the momentum that is applied when manually tapping the needle into the prostate and found a mean momentum of 0.50 ± 0.07 N s. The tapping device is pneumatically driven and we found that the delivered momentum increased linearly with the applied air pressure. The efficacy of the tapping device was tested on a piece of beef, placed on a freely moving and rotating platform. A significant correlation was found between the applied pressure and the rotation and displacement of the beef. Displacements and rotations were minimal for the highest pressure (4 bar) and amounted to only 2 mm and 6 deg., respectively. Higher air pressures will further reduce displacements and rotations

  1. [Deliberate release of the laryngeal adductor reflex via microdroplet impulses: Development of a device].

    Science.gov (United States)

    Ptok, M; Schroeter, S

    2016-03-01

    The laryngeal adductor reflex (LAR), a reflexive vocal fold closing mechanism, includes an early, probably di- or oligosynaptic ipsilateral LAR1- and a late ipsilateral and contralateral LAR2 polysynaptic component. In a clinical evaluation of dysphagia the LAR can be triggered by air pulses or tactile stimuli and typically assessed only qualitatively. The development and construction of a device that can selectively shoot very small water droplets (microdroplet impulse testing MIT). The MIT device has a water reservoir with an infinitely adjustable pressure. The opening period of the piezo-electrically operated valve determines the droplet size. With a high-speed camera system, the change in the airspeed of the drop can be determined, depending on the set water reservoir pressure. With the knowledge of the droplet size, the shooting speed and the estimation of the distance between the valve and laryngeal mucosa or airspeed can be determined the muzzle energy. By mounting the MIT device to a high speed glottography system, the time between the impact of the droplet on the laryngeal mucosa and the start of the laryngeal adduction, the LAR latency can be determined using an image by image evaluation. In dysphagia with penetration or aspiration it is presumed that the protective function of the larynx is no longer adequately ensured. The MIT-LAR device provides a valid and reliable method to assess LAR quantitatively. Furthermore, it holds the promise of being a simple to handle method that can be used clinically for routine diagnostics.

  2. A newly developed removable dental device for fused 3-D MRI/Meg imaging

    Energy Technology Data Exchange (ETDEWEB)

    Kuboki, Takuo [Okayama Univ. (Japan). Dental School; Clark, G T; Akhtari, M; Sutherling, W W

    1999-06-01

    Recently 3-D imaging techniques have been used to shed light on the role of abnormal brain functions in such conditions as nocturnal bruxism and orofacial pain. In order to achieve precise 3-D image fusion between magnetic resonance images (MRI) and magnetoencephalography (MEG) data, we developed a removable dental device which attaches rigidly to the teeth. Using this device, correlation of MEG and MRI data points was achieved by the co-registration of 3 or more fiducial points. Using a Polhemus 3-space digitizer the locations of the points were registered on MEG and then a small amount of high-water-content material was placed at each point for registering these same points on MRI. The mean reproducibility of interpoint distances, determined for 2 subjects, was between 0.59 and 0.82 mm. Using a Monte Carlo statistical analysis we determined that the accuracy of a posterior projection from the fiducial points to any point within the strata of the brain is {+-}3.3 mm. The value of this device is that it permits reasonably precise and repeatable co-registration of these points and yet it is easily removed and replaced by the patient. Obviously such a device could also be adapted for use in diagnosis and analysis of brain functions related with other various sensory and motor functions (e.g., taste, pain, clenching) in maxillofacial region using MRI and MEG. (author)

  3. A newly developed removable dental device for fused 3-D MRI/Meg imaging

    International Nuclear Information System (INIS)

    Kuboki, Takuo; Clark, G.T.; Akhtari, M.; Sutherling, W.W.

    1999-01-01

    Recently 3-D imaging techniques have been used to shed light on the role of abnormal brain functions in such conditions as nocturnal bruxism and orofacial pain. In order to achieve precise 3-D image fusion between magnetic resonance images (MRI) and magnetoencephalography (MEG) data, we developed a removable dental device which attaches rigidly to the teeth. Using this device, correlation of MEG and MRI data points was achieved by the co-registration of 3 or more fiducial points. Using a Polhemus 3-space digitizer the locations of the points were registered on MEG and then a small amount of high-water-content material was placed at each point for registering these same points on MRI. The mean reproducibility of interpoint distances, determined for 2 subjects, was between 0.59 and 0.82 mm. Using a Monte Carlo statistical analysis we determined that the accuracy of a posterior projection from the fiducial points to any point within the strata of the brain is ±3.3 mm. The value of this device is that it permits reasonably precise and repeatable co-registration of these points and yet it is easily removed and replaced by the patient. Obviously such a device could also be adapted for use in diagnosis and analysis of brain functions related with other various sensory and motor functions (e.g., taste, pain, clenching) in maxillofacial region using MRI and MEG. (author)

  4. Iron Oxide Nanoparticle-Based Magnetic Ink Development for Fully Printed Tunable Radio-Frequency Devices

    KAUST Repository

    Vaseem, Mohammad

    2018-01-30

    The field of printed electronics is still in its infancy and most of the reported work is based on commercially available nanoparticle-based metallic inks. Although fully printed devices that employ dielectric/semiconductor inks have recently been reported, there is a dearth of functional inks that can demonstrate controllable devices. The lack of availability of functional inks is a barrier to the widespread use of fully printed devices. For radio-frequency electronics, magnetic materials have many uses in reconfigurable components but rely on expensive and rigid ferrite materials. A suitable magnetic ink can facilitate the realization of fully printed, magnetically controlled, tunable devices. This report presents the development of an iron oxide nanoparticle-based magnetic ink. First, a tunable inductor is fully printed using iron oxide nanoparticle-based magnetic ink. Furthermore, iron oxide nanoparticles are functionalized with oleic acid to make them compatible with a UV-curable SU8 solution. Functionalized iron oxide nanoparticles are successfully embedded in the SU8 matrix to make a magnetic substrate. The as-fabricated substrate is characterized for its magnetostatic and microwave properties. A frequency tunable printed patch antenna is demonstrated using the magnetic and in-house silver-organo-complex inks. This is a step toward low-cost, fully printed, controllable electronic components.

  5. Development and Application of the Downhole Drilling String Shock-Absorption and Hydraulic Supercharging Device

    Directory of Open Access Journals (Sweden)

    Yongwang Liu

    2016-01-01

    Full Text Available It is a hot topic for deep/ultradeep wells to improve rock-breaking efficiency and drilling speed by available downhole energy. Based on different downhole energies and working conditions, specialized plunger pump is proposed to convert longitudinal vibration of drilling string into rock-breaking energy. Technical design is developed to generate high-pressure water jet. And then a simulation model is built to verify feasibility of the technical design. Through simulation, the influence law of key factors is obtained. On this basis, this device is tested in several wells. The result indicates this device can increase drilling speed as much as 136%. Meanwhile the harmful vibration can be absorbed. The energy from drilling string vibration is of high frequency and increases as well depth and formation anisotropy increase. By reducing adverse vibration, this device is able to increase the drilling speed and the service life also meets the demand of field application. The longest working time lasts for more than 130 hours. The performance of this device demonstrates great application prospect in deep/ultradeep resources exploration. To provide more equipment support for deep/ultradeep wells, more effort should be put into fundamental study on downhole drill string vibration and related equipment.

  6. Development of microfluidic devices for biomedical applications of synchrotron radiation infrared microspectroscopy

    OpenAIRE

    Birarda, Giovanni

    2011-01-01

    2009/2010 ABSTRACT DEVELOPMENT OF MICROFLUIDIC DEVICES FOR BIOMEDICAL APPLICATIONS OF SYNCHROTRON RADIATION INFRARED MICROSPECTROSCOPY by Birarda Giovanni The detection and measurement of biological processes in a complex living system is a discipline at the edge of Physics, Biology, and Engineering, with major scientific challenges, new technological applications and a great potential impact on dissection of phenomena occurring at tissue, cell, and sub cellular level. The ...

  7. Development of separation process of Dy, Y, Tm and Yb from heavier rare earth residue by solvent impregnated resin

    International Nuclear Information System (INIS)

    Shibata, J.; Matsumoto, S.

    1998-01-01

    Full text: Heavier rare earth which is contained in a small amount in ores such as bastnesite and monazite has been accumulated as heavier rare earth residue without doing separation and purification due to lack of suitable methods. The heavier rare earth residue includes seven rare earth elements such as Tb, Dy, Ho, Y, Er, Tm and Yb. Separation and recovery process of Dy, Y, Tm and Yb from leached solution of the heavier rare earth residue was investigated by using a column method with a solvent impregnated resin. The solvent impregnated resin was prepared by impregnation of organophosphorous extractant whose trade name is PC-88A into a macro porous resin, Amberlite XAD-7. It was almost impossible to separate them in simple adsorption and elution steps. However, we attained to individually separate Dy, Y, Tm and Yb from the leached solution first by changing eluent concentration gradually from pH 2 to 2mol/ l HCl in the elution step, and secondly by using a development column and changing eluent concentration in the elution step. The separation process flow was proposed for heavier rare earth residue by using the solvent impregnated resin method

  8. Mechanical circulatory assist device development at the Texas Heart Institute: a personal perspective.

    Science.gov (United States)

    Frazier, O H

    2014-01-01

    In December 2013, we performed our 1000th ventricular assist device implantation at the Texas Heart Institute. In my professional career, I have been fortunate to see the development of numerous mechanical circulatory support devices for the treatment of patients with advanced heart failure. In fact, most of the cardiac pumps in wide use today were developed in the Texas Heart Institute research laboratories in cooperation with the National Heart, Lung and Blood Institute or device innovators and manufacturers and implanted clinically at our partner St. Luke's Episcopal Hospital. My early involvement in this field was guided by my mentors, Dr Michael E. DeBakey and, especially, Dr Denton A. Cooley. Also, many of the advances are directly attributable to my ongoing clinical experience. What I learned daily in my surgical practice allowed me to bring insights to the development of this technology that a laboratory researcher alone might not have had. Young academic surgeons interested in this field might be well served to be active not only in laboratory research but also in clinical practice. Copyright © 2014 Elsevier Inc. All rights reserved.

  9. Development of DosiMap: dosimetry device for radiotherapy quality assurance

    International Nuclear Information System (INIS)

    Frelin, A.M.

    2006-10-01

    This thesis deals with the development of a new dosimetry device for the control of radiotherapy beams. This device is composed of a plane plastic scintillator which is set within a polystyrene phantom. When the 'DosiMap' is irradiated, light is produced. This light is composed of scintillation and Cerenkov radiation, and is accurately measured by a C.C.D. camera. The analysis of the light distribution enables us to deduce the dose distribution in the scintillator plan. This device has many advantages such as tissue equivalence, a good spatial resolution, and a linear response with regard to energy. It also provides immediate measurements, and as a consequence, it is a very adapted tool for clinical use. After the introduction about the basic notions of radiotherapy, the different steps of the 'DosiMap' development are exposed in this thesis. In a first time, plastic scintillators have been tested to determine the best one for this application. Then, the deconvolution of scintillation and Cerenkov radiation have been studied, because we only use scintillation to calculate the dose distribution. The camera being in the irradiation room, a lead shield has also been developed to protect the C.C.D. detector from scattered radiations. Finally, the dose calibration and the dose response of 'DosiMap' are exposed. All this work made feasible the measurement of dose distributions with a precision which turns out to be better than 2% for homogeneous photon beams. Excellent results were also obtained when modulated intensity beams are used. (author)

  10. Team-Based Development of Medical Devices: An Engineering-Business Collaborative.

    Science.gov (United States)

    Eberhardt, Alan W; Johnson, Ophelia L; Kirkland, William B; Dobbs, Joel H; Moradi, Lee G

    2016-07-01

    There is a global shift in the teaching methodology of science and engineering toward multidisciplinary, team-based processes. To meet the demands of an evolving technical industry and lead the way in engineering education, innovative curricula are essential. This paper describes the development of multidisciplinary, team-based learning environments in undergraduate and graduate engineering curricula focused on medical device design. In these programs, students actively collaborate with clinicians, professional engineers, business professionals, and their peers to develop innovative solutions to real-world problems. In the undergraduate senior capstone courses, teams of biomedical engineering (BME) and business students have produced and delivered numerous functional prototypes to satisfied clients. Pursuit of commercialization of devices has led to intellectual property (IP) disclosures and patents. Assessments have indicated high levels of success in attainment of student learning outcomes and student satisfaction with their undergraduate design experience. To advance these projects toward commercialization and further promote innovative team-based learning, a Master of Engineering (MEng) in Design and Commercialization was recently launched. The MEng facilitates teams of graduate students in engineering, life sciences, and business who engage in innovation-commercialization (IC) projects and coursework that take innovative ideas through research and development (R&D) to create marketable devices. The activities are structured with students working together as a "virtual company," with targeted outcomes of commercialization (license agreements and new start-ups), competitive job placement, and/or career advancement.

  11. Team-Based Development of Medical Devices: An Engineering–Business Collaborative

    Science.gov (United States)

    Eberhardt, Alan W.; Johnson, Ophelia L.; Kirkland, William B.; Dobbs, Joel H.; Moradi, Lee G.

    2016-01-01

    There is a global shift in the teaching methodology of science and engineering toward multidisciplinary, team-based processes. To meet the demands of an evolving technical industry and lead the way in engineering education, innovative curricula are essential. This paper describes the development of multidisciplinary, team-based learning environments in undergraduate and graduate engineering curricula focused on medical device design. In these programs, students actively collaborate with clinicians, professional engineers, business professionals, and their peers to develop innovative solutions to real-world problems. In the undergraduate senior capstone courses, teams of biomedical engineering (BME) and business students have produced and delivered numerous functional prototypes to satisfied clients. Pursuit of commercialization of devices has led to intellectual property (IP) disclosures and patents. Assessments have indicated high levels of success in attainment of student learning outcomes and student satisfaction with their undergraduate design experience. To advance these projects toward commercialization and further promote innovative team-based learning, a Master of Engineering (MEng) in Design and Commercialization was recently launched. The MEng facilitates teams of graduate students in engineering, life sciences, and business who engage in innovation-commercialization (IC) projects and coursework that take innovative ideas through research and development (R&D) to create marketable devices. The activities are structured with students working together as a “virtual company,” with targeted outcomes of commercialization (license agreements and new start-ups), competitive job placement, and/or career advancement. PMID:26902869

  12. Radionuclide separations in the nuclear fuel cycle development and application of micro and meso porous inorganic ion-exchangers

    International Nuclear Information System (INIS)

    Griffith, C.S.; Luca, V.

    2006-01-01

    Full text: Full text: From the mining of uranium-containing ores to the reprocessing of spent nuclear fuel, separations technologies play a crucial role in determining the efficiency and viability of the nuclear fuel cycle. With respect to proposed Advanced Nuclear Fuel Cycles (ANFC), the integral role of separations is no different with solvent extraction and pyroelectrometalurgical processing dominating efforts to develop a sustainable and publicly acceptable roadmap for nuclear power in the next 100 years. An often forgotten or overlooked separation technology is ion-exchange, more specifically, inorganic ion-exchangers. This is despite the fact that these materials offer the potential advantages of process simplicity; exceptional selectivity against high background concentrations of competing ions; and the possibility of a simple immobilization route for the separated radionculides. ANSTO's principal interest in inorganic ion-exchange materials in recent years has been the development of an inorganic ion-exchanger for the pretreatment of acidic legacy 9 Mo production waste to simultaneously remove radiogenic cesium and strontium. Radiogenic cesium and strontium comprise the majority of activity in such waste and may offer increased ease in the downstream processing to immobilise this waste in a Synroc wasteform. With the reliance on separations technologies in all current ANFC concepts, and the recent admission of ANSTO to the European Commissions EUROPART project, the development of new inorganic ion-exchangers has also expanded within our group. This presentation will provide a background of the fundamentals of inorganic and composite inorganic-organic ion-exchange materials followed by specific discussion of some selected inorganic and composite ion-exchange materials being developed and studied at ANSTO. The detailed structural and ion-exchange chemistry of these materials will be discussed and note made of how such materials could benefit any of the

  13. Development of respiratory motion reduction device system (RMRDs) for radiotherapy in moving tumors

    International Nuclear Information System (INIS)

    Lee, Suk; Yang, Dae-Sik; Choil, Myung-Sun; Kim, Chui-Yong

    2004-01-01

    The internal target volume (ITV) for tumors in the abdomen or thorax includes sufficient margin for breathing-related movement of tumor volumes during treatment. Depending on the location of the tumor, the magnitude of the ITV margin extends from 1 to 3 cm, which increases substantially the volume of the irradiated normal tissue, hence resulting in an increase in normal tissue complication probability (NTCP). We developed a simple and handy method which can reduce ITV margins in patients with moving tumors: the respiratory motion reduction device system (RMRDs). The patient's clinical database was structured for moving tumor patients and patient set-up error measurement and immobilization device effects were investigated. The system is composed of the respiration presser device (RPD) utilized in the prone position and the abdominal strip device (ASD) utilized in the supine position, and the analysis program, which enables analysis of patient set-up reproducibility. It was tested for analyzing the diaphragm movement from patients with RMRDs, the magnitude of the ITV margin was determined and the dose-volume histogram (DVH) was computed using treatment planning software. The dose to normal tissue in patients with and without RMRDs was analyzed by comparing the fraction of the normal liver receiving 50% of the isocenter dose. Average diaphragm movement due to respiration was 16±1.9 mm in the case of the supine position, and 12±1.9 mm in the case of the prone position. When utilizing the RMRDs, which was personally developed in our hospital, the value was reduced to 5±1.4 mm, and in the case in which the belt immobilization device was utilized, the value was reduced to 3±0.9 mm. In the case where the strip device was utilized, the value was proven to reduce to 4±0.3 mm. As a result of analyzing the volume of normal liver where 50% of the prescription dose is irradiated in DVH according to the radiation treatment planning, the use of the RMRD can create a reduction

  14. High-density plasma etching of III-nitrides: Process development, device applications and damage remediation

    Science.gov (United States)

    Singh, Rajwinder

    Plasma-assisted etching is a key technology for III-nitride device fabrication. The inevitable etch damage resulting from energetic pattern transfer is a challenge that needs to be addressed in order to optimize device performance and reliability. This dissertation focuses on the development of a high-density inductively-coupled plasma (ICP) etch process for III-nitrides, the demonstration of its applicability to practical device fabrication using a custom built ICP reactor, and development of techniques for remediation of etch damage. A chlorine-based standard dry etch process has been developed and utilized in fabrication of a number of electronic and optoelectronic III-nitride devices. Annealing studies carried out at 700°C have yielded the important insight that the annealing time necessary for making good-quality metal contacts to etch processed n-GaN is very short (water, prior to metallization, removes some of the etch damage and is helpful in recovering contact quality. In-situ treatment consisting of a slow ramp-down of rf bias at the end of the etch is found to achieve the same effect as the ex-situ treatment. This insitu technique is significantly advantageous in a large-scale production environment because it eliminates a process step, particularly one involving treatment in hydrochloric acid. ICP equipment customization for scaling up the process to full 2-inch wafer size is described. Results on etching of state of the art 256 x 256 AlGaN focal plane arrays of ultraviolet photodetectors are reported, with excellent etch uniformity over the wafer area.

  15. Development of a feeder device for logging residue for a drum chipper; Hakkurin syoetoen kehittaeminen energiapuulle

    Energy Technology Data Exchange (ETDEWEB)

    Leinonen, T.; Kemppainen, J P [Oulu Univ. (Finland). Dept. of Mechanical Engineering

    1997-12-01

    The aim of this project is to increase the productivity of a large drum chipper by developing a feeder device to be used especially when chipping logging residue. Logging residue from regeneration areas is the most important reserve of forest biomass for the production of renewable energy in Finland. It is possible ecologically and economically to use about 5 million m{sup 3} of logging residue yearly for energy purposes. Currently both large lorry based chippers and smaller forwarder based chippers are used for chipping logging residue. However even the latest versions of these chippers are not well equipped for chipping logging residue. The ball like shape of residue piles causes blockades, if too large amounts of residue are fed into the chipper. Keeping the material flow even is difficult. In this project a prototype of a feeder device will be designed and manufactured to exactly find out the problems, that occur when feeding logging residue to a chipper. The designed prototype is based on a tubular chassis, which supports a conveyor made of steel plates. Prototype also has a 2,5 m wide feeding table and a feeder roll, which is located above the conveyor just before the chipper opening. Both the conveyor and the feeder roll are powered by hydraulic motors. The maximum feeding force is 20 kN. For research purposes both hydraulic pressure and flow can be adjusted individually for both motors. During 1996 activities included designing and building the prototype feeder device. In 1997 the prototype will be tested to find out possible problems, which need to be cured. After problems are solved and other improvements are made, the feeder device will be installed to an existing chipper and then tested again to determine the productivity of the new feeder device compared to the old unit. (orig.)

  16. Development program for magnetically assisted chemical separation: Evaluation of cesium removal from Hanford tank supernatant

    International Nuclear Information System (INIS)

    Nunez, L.; Buchholz, B.A.; Ziemer, M.; Dyrkacz, G.; Kaminski, M.; Vandegrift, G.F.; Atkins, K.J.; Bos, F.M.; Elder, G.R.; Swift, C.A.

    1994-12-01

    Magnetic particles (MAG*SEP SM ) coated with various absorbents were evaluated for the separation and recovery of low concentrations of cesium from nuclear waste solutions. The MAG*SEP SM particles were coated with (1) clinoptilolite, (2) transylvanian volcanic tuff, (3) resorcinol formaldehyde, and (4) crystalline silico-titanate, and then were contacted with a Hanford supernatant simulant. Particles coated with the crystalline silico-titanate were identified by Bradtec as having the highest capacity for cesium removal under the conditions tested (variation of pH, ionic strength, cesium concentration, and absorbent/solution ratio). The MAG*SEP SM particles coated with resorcinol formaldehyde had high distribution ratios values and could also be used to remove cesium from Hanford supernant simulant. Gamma irradiation studies were performed on the MAG*SEP SM particles with a gamma dose equivalent to 100 cycles of use. This irradiation decreased the loading capacity and distribution ratios for the particles by greater than 75%. The particles demonstrated high sensitivity to radiolytic damage due to the degradation of the polymeric regions. These results were supported by optical microscopy measurements. Overall, use of magnetic particles for cesium separation under nuclear waste conditions was found to be marginally effective

  17. Application of recently developed elliptic blending based models to separated flows

    International Nuclear Information System (INIS)

    Billard, F.; Revell, A.; Craft, T.

    2012-01-01

    Highlights: ► The study focuses on elliptic blending near-wall models. ► Models are compared on 2- and 3-dimensional separating flows. ► Conclusions are ambiguous on 2-d flows. ► Predictive superiority of Reynolds stress models over eddy viscosity model appear on 3-d flows. - Abstract: This paper considers the application of four Reynolds-Averaged Navier Stokes (RANS) models to a range of progressively complex test cases, exhibiting both 2-d and 3-d flow separation. Two Eddy Viscosity Models (EVM) and two Reynolds Stress Transport Models (RSM) are employed, of which two (one in each category) are based on elliptic blending formulations. By both reviewing the conclusions of previous studies, and from the present calculations, this study aims at gaining more insight into the importance of two modelling features for these flows: the usage of turbulence anisotropy resolving schemes, and the near-wall limiting behaviour. In general the anisotropy and near wall treatment offered by both elliptic blending models is observed to offer some improvement over other models tested, although this is not always the case for the 2-d flows, where (as ever) a single “best candidate” model does not emerge.

  18. Developing Effective Separation of Feldspar and Quartz While Recycling Tailwater by HF Pretreatment

    Directory of Open Access Journals (Sweden)

    Weiqing Wang

    2018-04-01

    Full Text Available The effect of hydrofluoric acid (HF pretreatment on flotation of feldspar and quartz using dodecylamine (DDA as collector was investigated by micro-flotation, zeta potential, pyrene fluorescence spectroscopy, attenuated total reflection flourier transformed infrared spectroscopy (ATR-FTIR, scanning electron microscope (SEM, X-ray photoelectron spectroscopy (XPS and bench scale flotation. The micro-flotation tests revealed that there was little difference in the flotation of feldspar and quartz at pH 2, using H2SO4 as pH regulator. After HF pretreatment, the floatability of feldspar significantly increased while the floatability of quartz showed no change. HF pretreatment resulted in leaching of SiO2 and enrichment of Na, K and Al on the feldspar surface. Consequently, the negative surface charge of feldspar increased at pH 2, which allowed for the flotation separation of the feasible minerals. This took place via an increased electrostatic adsorption between DDA and Na, K, Al on the feldspar surface, which effectively increased its hydrophobicity and as a result, improved the floatability of feldspar. An alternative process which exhibited effective separation of quartz and feldspar while recycling the tailwater from the flotation was proposed.

  19. CONSIDERATIONS FOR THE DEVELOPMENT OF A DEVICE FOR THE DECOMMISSIONING OF THE HORIZONTAL FUEL CHANNELS IN THE CANDU 6 NUCLEAR REACTOR. PART 6 - PRESENTATION OF THE DECOMMISSIONING DEVICE

    Directory of Open Access Journals (Sweden)

    Gabi ROSCA FARTAT

    2015-05-01

    dismantling and extraction of the channel closure plug and shield plug, extraction of the end fitting, cutting and extraction of the pressure tube. The fuel channel decommissioning device consists of following major components: coupling and locking fuel channel module, assembly valve for access to the fuel channel, storage tubes assembly for extracted components, handling elements assembly, cutting and extraction device and housing device. The design of the device and platform support is achieved according to the particular features of the fuel channel components to be dismantled in the program of nuclear reactor decommissioning according to all the safety aspects and environmental protection during the activities, resulting from the decommissioning plan developed.

  20. LWAs computational platform for e-consultation using mobile devices: cases from developing nations.

    Science.gov (United States)

    Olajubu, Emmanuel Ajayi; Odukoya, Oluwatoyin Helen; Akinboro, Solomon Adegbenro

    2014-01-01

    Mobile devices have been impacting on human standard of living by providing timely and accurate information anywhere and anytime through wireless media in developing nations. Shortage of experts in medical fields is very obvious throughout the whole world but more pronounced in developing nations. Thus, this study proposes a telemedicine platform for the vulnerable areas of developing nations. The vulnerable area are the interior with little or no medical facilities, hence the dwellers are very susceptible to sicknesses and diseases. The framework uses mobile devices that can run LightWeight Agents (LWAs) to send consultation requests to a remote medical expert in urban city from the vulnerable interiors. The feedback is conveyed to the requester through the same medium. The system architecture which contained AgenRoller, LWAs, The front-end (mobile devices) and back-end (the medical server) is presented. The algorithm for the software component of the architecture (AgenRoller) is also presented. The system is modeled as M/M/1/c queuing system, and simulated using Simevents from MATLAB Simulink environment. The simulation result presented show the average queue length, the number of entities in the queue and the number of entities departure from the system. These together present the rate of information processing in the system. A full scale development of this system with proper implementation will help extend the few medical facilities available in the urban cities in developing nations to the interiors thereby reducing the number of casualties in the vulnerable areas of the developing world especially in Sub Saharan Africa.