WorldWideScience

Sample records for sector mal drenado

  1. Mal de terre

    CERN Document Server

    Reeves, Hubert

    2003-01-01

    Notre planète va mal: réchauffement climatique, épuisement des ressources naturelles, pollutions des sols et de l'eau provoquées par les industries civiles et guerrières, disparité des richesses, malnutrition des hommes, taux d'extinction effarant des espèces vivantes, etc.

  2. Grand Mal Seizure

    Science.gov (United States)

    ... Withdrawal syndromes Using or withdrawing from drugs, including alcohol Risk factors Risk factors for grand mal seizures include: ... that affect electrolyte balance Illicit drug use Heavy alcohol use ... or others. You might be at risk of: Falling. If you fall during a seizure, ...

  3. Maltose-Dependent Transcriptional Regulation of the mal Regulon by MalR in Streptococcus pneumoniae

    NARCIS (Netherlands)

    Afzal, Muhammad; Shafeeq, Sulman; Manzoor, Irfan; Kuipers, Oscar P

    2015-01-01

    The maltose regulon (mal regulon) has previously been shown to consist of the mal gene cluster (malMP, malXCD and malAR operons) in Streptococcus pneumoniae. In this study, we have further elucidated the complete mal regulon in S. pneumoniae D39 using microarray analyses and β-galactosidase assays.

  4. El Gobierno del mal menor

    DEFF Research Database (Denmark)

    Agustin, Oscar Garcia

    2012-01-01

    El Gobierno no aspira a ser bueno ni malo. Se conforma con ser el Gobierno del mal menor, cuyas medidas drásticas y poco populares están destinadas a salvar a los ciudadanos del desastre que no ha llegado todavía pero podría llegar....

  5. Virus Characterization by FFF-MALS Assay

    Science.gov (United States)

    Razinkov, Vladimer

    2009-03-01

    Adequate biophysical characterization of influenza virions is important for vaccine development. The influenza virus vaccines are produced from the allantoic fluid of developing chicken embryos. The process of viral replication produces a heterogeneous mixture of infectious and non-infectious viral particles with varying states of aggregation. The study of the relative distribution and behavior of different subpopulations and their inter-correlation can assist in the development of a robust process for a live virus vaccine. This report describes a field flow fractionation and multiangle light scattering (FFF-MALS) method optimized for the analysis of size distribution and total particle counts. A method using a combination of asymmetric flow field-flow fractionation (AFFFF) and multiangle light scattering (MALS) techniques has been shown to improve the estimation of virus particle counts and the amount of aggregated virus in laboratory samples. The FFF-MALS method was compared with several other methods such as transmission electron microscopy (TEM), atomic force microscopy (AFM), size exclusion chromatography followed by MALS (SEC-MALS), quantitative reverse transcription polymerase chain reaction (RT Q-PCR), median tissue culture dose (TCID(50)), and the fluorescent focus assay (FFA). The correlation between the various methods for determining total particle counts, infectivity and size distribution is reported. The pros and cons of each of the analytical methods are discussed.

  6. Malária : o problema

    OpenAIRE

    Atouguia, Jorge

    2007-01-01

    Recursos Educativos - Ciências Este videograma apresenta a problemática da Malária no mundo, nomeadamente em termos de distribuição Mundial, tipos de parasitas, grupos de risco, impacto socioeconómico e perspetivas de controlo. Depoimento de Filomeno Fortes, do Programa Nacional do Controlo da Malária. Produção no âmbito do projeto “Saúde Tropical” para formação de técnicos de saúde, de países africanos de língua portuguesa.

  7. Analysis of refrigerant mal-distribution

    DEFF Research Database (Denmark)

    Kærn, Martin Ryhl; Elmegaard, Brian

    2009-01-01

    to be two straight tubes. The refrigerant maldistribution is then induced to the evaporator by varying the vapor quality at the inlet to each tube and the air-flow across each tube. Finally it is shown that mal-distribution can be compensated by an intelligent distributor, that ensures equal superheat...

  8. Kewenangan Baitul Mal Aceh dalam Pendistribusian Zakat

    Directory of Open Access Journals (Sweden)

    Surya Darma

    2017-08-01

    ABSTRACT: Aceh is a province in Indonesia that is granted a special authority to govern and manage its own government affairs. One of them is zakat as one of the original source of income. Baitul Mal institution is established by qanun (local law to manage the zakat fund. In regard with its management procedure as the original revenue of the area, which is managed by Baitul Mal, is regulated in qanun and governor regulation. Its expenditure or distribution is in accordance with the guidance of the Islamic Sharia, that is, it may only be the part specified in the Qur'an, not for others. One of the forms of its distributions’ forms is the provision of vocational capital to productive zakat recipients through Productive Zakat Management Units. It is done in the form of interest-free loans. It is slightly different, as the zakat must be divided in full without needing to be returned. Although its interest-free loan is legal, it requires further explanation to avoid negative views. The finding shows that in 2013, 2014 and 2015, Baitul Mal Aceh, gains its funds more than expected. It requires careful handling in order to avoid  any problems in the future.

  9. Pandora y Eva. El origen del mal

    OpenAIRE

    Calvo Martínez, José Luis

    2015-01-01

    La conferencia "PANDORA Y EVA. EL ORIGEN DEL MAL" pone de relieve el paralelismo que se revela obvio entre el mito griego de Pandora y el relato bíblico centrado en Eva en el Génesis. Y su dependencia última de Oriente. Ambos relatos, que presentan ciertos mitemas adicionales aprovechados de manera diferente, quieren poner de relieve la degradación del ser humano desde su creación dentro de una condición de eterna felicidad, en el mismo plano de la divinidad, y su entrada en el ciclo de la mo...

  10. Savoir gérer le mal

    Directory of Open Access Journals (Sweden)

    Michel Maffesoli

    2015-09-01

    Full Text Available Le sens commun, conservatoire immémorial de la sagesse humaine « sait », de savoir incorporé, que le mal, l’ombre, la mort, la douleur sont des caractéristiques essentielles de l’existence en son entièreté. Dès lors les créatures quelles qu’elles soient, sont des manifestations de la vie et, dès lors, méritent une attitude « compassionnelle », fraternelle, parce qu’ensemble elles constituent le flux vital. C’est ainsi que l’on peut comprendre l’utilité sociale de ces divers « mondes intermédiaires » que sont les croyances, religieuses ou philosophiques, au « double », au « daimon », aux esprits et autres figures tutélaires ou effrayantes. Elles aident à vivre, au jour le jour, la souffrance en la communalisant.

  11. Arendt, Eichmann y la banalidad del mal

    Directory of Open Access Journals (Sweden)

    López, Marina

    2010-04-01

    Full Text Available In this text I describe the characteristics that Hannah Arendt attributes to the SS agents through the figure of Eichmann, during the German Nazi regime of the 20th century. According to this characterization, I intend to show, on the one hand, that there is not a break in Arendt’s thought on evil, i.e. from The Origins of Totalitarianism to Eichmann in Jerusalem: a report on the banality of evil, but a continuous line of thought. And, on the other hand, I try to follow the clues that Arendt gives concerning the “banality” that defines the behavior of individuals such as Eichmann. Both premises will permit me to point out what, in my understanding, the banalization of humanity implies, not only in the context of the Jewish Holocaust, but in each of the societies in which the elimination of spontaneity is a reality.

    En el texto se describen las características que Hannah Arendt, a través de la figura de Eichmann, atribuye a los agentes SS durante el régimen nazi alemán de mediados del siglo XX. Con la caracterización se persigue mostrar, en principio, que no hay una ruptura en el pensamiento de Hannah Arendt respecto a su manera de considerar el mal, desde Los orígenes del Totalitarismo hasta Eichmann en Jerusalén, un estudio sobre la banalidad del mal, sino una continuidad y, por otra parte, seguir las pistas que Arendt propone en torno a la “banalidad” que define el comportamiento de individuos como Eichmann. Ambas premisas nos permitirán poner de relieve lo que, a nuestro parecer, implica la banalización de la humanidad no sólo en el contexto del Holocausto judío, sino en cada una de las sociedades en las que la eliminación de la espontaneidad es una realidad.

  12. AKSESIBILITAS HOTEL HORISON BEKASI DENGAN MAL METROPOLITAN

    Directory of Open Access Journals (Sweden)

    Nadia Nursintia

    2016-03-01

    Full Text Available Abstract - Development of accommodation services is growing very fast, the construction of hotels ranging from low to star property confirms that the business is very profitable and promising. Growing hotel development as the presence and development of tourism in a region. Concept of mix used and are now growing in demand by developers. In addition to shorten the land, its facilities are increasingly in demand, because the concept of developing the land into two business buildings comprising the hotel and mall, can provide ease of access for service users to carry out all the activities that support their activities. Accessibility is a very important thing to be considered for the service users to choose the hotel accommodation that will be flown them. Distance, transportation, facilities, road conditions, and ease of location had been the benchmark and consideration to get a suitable hotel for their activities.   Keyword : Accessibility, Hotel   Abstrak - Perkembangan jasa akomodasi saat ini berkembang sangat cepat, dibangunnya hotel mulai dari hotel rendah hingga bintang menegaskan bahwa bisnis properti ini sangat menguntungkan dan menjanjikan. Pembangunan hotel berkembang seiring hadirnya dan berkembangnya pariwisata di suatu daerah. Konsep mix used pun kini semakin berkembang dan diminati oleh para pengembang. Selain karena mempersingkat lahan, fasilitas nya pun semakin diminati, karena konsep mengembangkan satu lahan menjadi dua bangunan usaha yang terdiri dari hotel dan mal, dapat memberikan kemudahan akses untuk para pengguna jasa untuk melakukan segala aktifitas yang mendukung kegiatannya. Aksesbilitas merupakan hal yang sangat penting yang menjadi pertimbangan bagi para pengguna jasa akomodasi untuk memilih hotel yang akan mereka singgahi. Jarak, transportasi, fasilitas, kondisi jalan, dan kemudahan lokasi lah yang menjadi tolak ukur dan pertimbangan untuk mendapatkan hotel yang cocok bagi kegiatan mereka.   Kata Kunci

  13. La mal nutrición

    OpenAIRE

    Instituto Nacional de Salud

    2009-01-01

    En realidad, la malnutrición ya sea por déficit o exceso, es un problema que afecta a la población en general, lo que hace necesario un trabajo multidisciplinario e interinstitucional de los sectores de educación, agricultura y salud, dirigido fundamentalmente a la población vulnerable (niños menores de cinco años, mujeres embarazadas y en periodo de lactancia e indígenas).

  14. The MAL: A Malware Analysis Lexicon

    Science.gov (United States)

    2013-02-01

    by protocol (email, web, etc.) to facilitate analysis. Trojan horse A piece of malicious code disguised as something inert or benign. trusted...tools and techniques that helps developers harden their application code against reverse engineering.3 appender A file-infecting virus that places...control a system.7 bochs An open source processor emulator for x86 and x86–64 processors. CMU/SEI-2013-TN-010 | 11 boot sector virus A virus

  15. El mal de ojo como enfermedad: elitelore y folklore en Iberoamérica

    Directory of Open Access Journals (Sweden)

    Idoyaga Molina, Anatilde

    2014-06-01

    Full Text Available The article claims that general theories about the evil eye lore have not considered its occurrences as an illness, the gazer´s and victim´s characterization in terms of ancient Western medicine, as well as the naturalization of moral contents. The authors sustain that the evil eye in Iberoamerica is a folk illness, whose etiological theories exceed the human domain, including animals as aggressors. The evil eye lore as an illness incorporates natural etiologies, and social theories linked to envy, anger, fondness and love. To overcome these supposed contradictions, the authors call the attention to consider the historical processes of construction of the evil eye lore, taking into account the process of filtering down from the elite and medical official knowledge to popular sectors, underlining the relevance of being aware of the evil eye was defined as a real disease, during the Middle and Modern Ages.Revisamos los marcos conceptuales del mal de ojo, destacando que tales teorías dejan de lado sus manifestaciones como enfermedad, la caracterización de los ojeadores y de las víctimas en términos de la antigua medicina científica. Los autores sostienen que el mal de ojo en Iberoamérica es el nombre de una enfermedad, cuyos contenidos y teorías etiológicas exceden el dominio humano, incluyendo ojeadores animales. Como enfermedad incorpora causas naturales, además de causas sociales ligadas con la envidia, los celos, el encono y el cariño. Para entender estas manifestaciones, aparentemente contradictorias, se llama la atención sobre la relevancia de considerar los procesos históricos de construcción de la creencia en el mal de ojo, la relación entre los saberes de elite y los procesos de popularización de esos saberes, subrayando la relevancia del reconocimiento del mal de ojo como enfermedad por la antigua medicina académica en tales procesos.

  16. Evolution of mal ABC transporter operons in the Thermococcales and Thermotogales.

    Science.gov (United States)

    Noll, Kenneth M; Lapierre, Pascal; Gogarten, J Peter; Nanavati, Dhaval M

    2008-01-15

    The mal genes that encode maltose transporters have undergone extensive lateral transfer among ancestors of the archaea Thermococcus litoralis and Pyrococcus furiosus. Bacterial hyperthermophiles of the order Thermotogales live among these archaea and so may have shared in these transfers. The genome sequence of Thermotoga maritima bears evidence of extensive acquisition of archaeal genes, so its ancestors clearly had the capacity to do so. We examined deep phylogenetic relationships among the mal genes of these hyperthermophiles and their close relatives to look for evidence of shared ancestry. We demonstrate that the two maltose ATP binding cassette (ABC) transporter operons now found in Tc. litoralis and P. furiosus (termed mal and mdx genes, respectively) are not closely related to one another. The Tc. litoralis and P. furiosus mal genes are most closely related to bacterial mal genes while their respective mdx genes are archaeal. The genes of the two mal operons in Tt. maritima are not related to genes in either of these archaeal operons. They are highly similar to one another and belong to a phylogenetic lineage that includes mal genes from the enteric bacteria. A unique domain of the enteric MalF membrane spanning proteins found also in these Thermotogales MalF homologs supports their relatively close relationship with these enteric proteins. Analyses of genome sequence data from other Thermotogales species, Fervidobacterium nodosum, Thermosipho melanesiensis, Thermotoga petrophila, Thermotoga lettingae, and Thermotoga neapolitana, revealed a third apparent mal operon, absent from the published genome sequence of Tt. maritima strain MSB8. This third operon, mal3, is more closely related to the Thermococcales' bacteria-derived mal genes than are mal1 and mal2. F. nodosum, Ts. melanesiensis, and Tt. lettingae have only one of the mal1-mal2 paralogs. The mal2 operon from an unknown species of Thermotoga appears to have been horizontally acquired by a Thermotoga

  17. Evolution of mal ABC transporter operons in the Thermococcales and Thermotogales

    Directory of Open Access Journals (Sweden)

    Gogarten J Peter

    2008-01-01

    Full Text Available Abstract Background The mal genes that encode maltose transporters have undergone extensive lateral transfer among ancestors of the archaea Thermococcus litoralis and Pyrococcus furiosus. Bacterial hyperthermophiles of the order Thermotogales live among these archaea and so may have shared in these transfers. The genome sequence of Thermotoga maritima bears evidence of extensive acquisition of archaeal genes, so its ancestors clearly had the capacity to do so. We examined deep phylogenetic relationships among the mal genes of these hyperthermophiles and their close relatives to look for evidence of shared ancestry. Results We demonstrate that the two maltose ATP binding cassette (ABC transporter operons now found in Tc. litoralis and P. furiosus (termed mal and mdx genes, respectively are not closely related to one another. The Tc. litoralis and P. furiosus mal genes are most closely related to bacterial mal genes while their respective mdx genes are archaeal. The genes of the two mal operons in Tt. maritima are not related to genes in either of these archaeal operons. They are highly similar to one another and belong to a phylogenetic lineage that includes mal genes from the enteric bacteria. A unique domain of the enteric MalF membrane spanning proteins found also in these Thermotogales MalF homologs supports their relatively close relationship with these enteric proteins. Analyses of genome sequence data from other Thermotogales species, Fervidobacterium nodosum, Thermosipho melanesiensis, Thermotoga petrophila, Thermotoga lettingae, and Thermotoga neapolitana, revealed a third apparent mal operon, absent from the published genome sequence of Tt. maritima strain MSB8. This third operon, mal3, is more closely related to the Thermococcales' bacteria-derived mal genes than are mal1 and mal2. F. nodosum, Ts. melanesiensis, and Tt. lettingae have only one of the mal1-mal2 paralogs. The mal2 operon from an unknown species of Thermotoga appears to

  18. 7 CFR 1421.418 - Submitting MAL and LDP documentation to FSA.

    Science.gov (United States)

    2010-01-01

    ... receipts or EWR numbers, and the EWR provider's name representing the bundled MALs or LDPs. (2) A form to..., if CCC was not the holder of the EWR on or before the date the DMA prepared MAL was disbursed, the... CCC becomes the holder of the EWR. (e) If MAL and LDP documentation is acceptable, FSA will disburse...

  19. Agriculture Sectors

    Science.gov (United States)

    The Agriculture sectors comprise establishments primarily engaged in growing crops, raising animals, and harvesting fish and other animals. Find information on compliance, enforcement and guidance on EPA laws and regulations on the NAICS 111 & 112 sectors.

  20. Microbiologic methods utilized in the MAL-ED cohort study.

    Science.gov (United States)

    Houpt, Eric; Gratz, Jean; Kosek, Margaret; Zaidi, Anita K M; Qureshi, Shahida; Kang, Gagandeep; Babji, Sudhir; Mason, Carl; Bodhidatta, Ladaporn; Samie, Amidou; Bessong, Pascal; Barrett, Leah; Lima, Aldo; Havt, Alexandre; Haque, Rashidul; Mondal, Dinesh; Taniuchi, Mami; Stroup, Suzanne; McGrath, Monica; Lang, Dennis

    2014-11-01

    A central hypothesis of The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) study is that enteropathogens contribute to growth faltering. To examine this question, the MAL-ED network of investigators set out to achieve 3 goals: (1) develop harmonized protocols to test for a diverse range of enteropathogens, (2) provide quality-assured and comparable results from 8 global sites, and (3) achieve maximum laboratory throughput and minimum cost. This paper describes the rationale for the microbiologic assays chosen and methodologies used to accomplish the 3 goals. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  1. O conceito de mal radical The concept of radical evil

    Directory of Open Access Journals (Sweden)

    Adriano Correia

    2005-01-01

    Full Text Available A noção de mal radical aparece em Kant no contexto da discussão da religião nos limites da simples razão e busca dar conta da complexa relação entre o respeito pela lei moral e o amor-próprio na definição do móbil para a ação. Na busca por identificar o fundamento da propensão para o mal no homem, Kant se vê diante da dificuldade de ter de articular natureza e liberdade, e ainda que a noção de mal radical possa conservar algumas ambigüidades, permite conceber uma noção de responsabilidade compatível com uma inata propensão para o mal. Neste texto busco explicitar alguns passos fundamentais na construção do conceito por Kant.The concept of radical evil appears in Kant's theory when he discusses the religion in the limits of the mere reason and aims explain the complex relationship between respect for the moral law and the self-love, for establish the motive of the action. By aiming identify the basis of human inclination to evil, Kant is faced with the trouble of have to put nature and freedom in connection. Despite of the concept of radical evil retain some ambiguity, it allows conceive a notion of responsibility suitable to an inherent inclination to evil. In this paper is my purpose to explain some basic moments of Kantian formulation of that notion.

  2. Modelling of innovative SANEX process mal-operations

    Energy Technology Data Exchange (ETDEWEB)

    McLachlan, F. [National Nuclear Laboratory, Building D5, Culham Science Centre, Abingdon, Oxfordshire OX14 3DB (United Kingdom); Taylor, R.; Whittaker, D.; Woodhead, D. [National Nuclear Laboratory, Central Laboratory, Sellafield, Seascale, Cumbria CA20 1PG (United Kingdom); Geist, A. [Karlsruhe Institute of Technology - KIT, 76021, Karlsruhe (Germany)

    2016-07-01

    The innovative (i-) SANEX process for the separation of minor actinides from PUREX highly active raffinate is expected to employ a solvent phase comprising 0.2 M TODGA with 5 v/v% 1-octanol in an inert diluent. An initial extract / scrub section would be used to extract trivalent actinides and lanthanides from the feed whilst leaving other fission products in the aqueous phase, before the loaded solvent is contacted with a low acidity aqueous phase containing a sulphonated bis-triazinyl pyridine ligand (BTP) to effect a selective strip of the actinides, so yielding separate actinide (An) and lanthanide (Ln) product streams. This process has been demonstrated in lab scale trials at Juelich (FZJ). The SACSESS (Safety of Actinide Separation processes) project is focused on the evaluation and improvement of the safety of such future systems. A key element of this is the development of an understanding of the response of a process to upsets (mal-operations). It is only practical to study a small subset of possible mal-operations experimentally and consideration of the majority of mal-operations entails the use of a validated dynamic model of the process. Distribution algorithms for HNO{sub 3}, Am, Cm and the lanthanides have been developed and incorporated into a dynamic flowsheet model that has, so far, been configured to correspond to the extract-scrub section of the i-SANEX flowsheet trial undertaken at FZJ in 2013. Comparison is made between the steady state model results and experimental results. Results from modelling of low acidity and high temperature mal-operations are presented. (authors)

  3. Electroencephalogram Signals Processing for the Diagnosis of Petit mal and Grand mal Epilepsies Using an Artificial Neural Network

    Directory of Open Access Journals (Sweden)

    M. R. Arab

    2010-04-01

    Full Text Available In this study, a novel wavelet transform‐neural network method is presented. The presented method is used for theclassification of grand mal (clonic stage and petit mal (absence epilepsies into healthy, ictal and interictal (EEGs. Preprocessingis included to remove an artifact occurred by blinking and a wandering baseline (electrodes movement as well as an eyeballmovement artifact using the Discrete Wavelet Transformation (DWT. Denoising EEG signals from the AC power supplyfrequency with a suitable notch filter is another job of preprocessing. The preprocessing enhanced speed and accuracy of theprocessing stage (wavelet transform and neural network. The EEGs signals are categorized into normal and petit mal and clonicepilepsy by an expert neurologist. The categorization is confirmed by the Fast Fourier Transform (FFT analysis. The datasetincludes waves such as sharp, spike and spike‐slow wave. Through the Countinous Wavelet Transform (CWT of EEG records,transient features are accurately captured and separated and used as classifier input. We introduce a two‐stage classifier basedon the Learning Vector Quantization (LVQ neural network localized in both time and frequency contexts. The particularcoefficients of the Continuous Wavelet Transform (CWT are networks. The simulation results are very promising and theaccuracy of the proposed method obtained is of about 80%.

  4. Maltose-binding protein effectively stabilizes the partially closed conformation of the ATP-binding cassette transporter MalFGK2

    KAUST Repository

    Weng, Jingwei

    2017-02-23

    Maltose transporter MalFGK2 is a type-I importer in the ATP-binding cassette (ABC) transporter superfamily. Upon the binding of its periplasmic binding protein, MalE, the ATPase activity of MalFGK2 can be greatly enhanced. Crystal structures of the MalFGK2-MalE-maltose complex in a so-called

  5. Polirradiculoneurite e malária: relato de um caso

    Directory of Open Access Journals (Sweden)

    Carlos A. M. Guerreiro

    1985-06-01

    Full Text Available Registro de caso de paciente que três semanas após malária por Plasmodium falciparum desenvolveu forma severa de polirradiculoneurite, com tetraplegia e comprometimento de vários nervos cranianos (VI, VII, IX, X, evoluindo para a morte. A síndrome de Guillain-Barré tem sido considerada desordem imune relacionada a diversos estímulos antigênicos desencadeantes. O caso registrado sugere que protozoários podem ser um desses fatores antigênicos.

  6. Historia de la voluntad y banalidad del mal

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    Prior Olmos, Ángel

    2010-04-01

    Full Text Available This article discusses the connections existing in The Life of the Mind between the theory of the banality of evil and the history of the will. It interprets Eichmann in Jerusalem as a work about bureaucratic evil, but above all as research concerning both moral and juridical responsibility. From the history of the will it highlights three different aspects that can be connected with the problem of responsibility: the ontology of contingency, the idea of individuality linked to the will and the capacity of transcendence and resistance that we see in the Duns Scotus’ theory, where liberty equals indifference. Finally, it suggests a link between the banality of evil and the ontology of good as these are present in “Some questions of moral philosophy” (1965-1966, the fight against Gnosticism and the defense of a relationship between morality and evil’s intelligibility.

    El artículo plantea las conexiones entre la tesis de la banalidad del mal y la historia de la voluntad presente en La vida del espíritu. Interpreta Eichmann en Jerusalén como una obra sobre el mal burocrático, pero sobre todo como estudio acerca de la responsabilidad, tanto jurídica como moral. De la historia de la voluntad resalta tres aspectos que pueden ser puestos en conexión con el problema de la responsabilidad: la ontología de la contingencia, la idea de individualidad vinculada a la voluntad y la capacidad de trascendencia y resistencia subyacentes en la teoría de Duns Escoto de la libertad como indiferencia. Por último, sugiere una vinculación entre la banalidad del mal y la ontología del bien desarrolladas en “Algunas cuestiones de filosofía moral”, de 1965-1966, la lucha contra el gnosticismo y la defensa de una relación entre moralidad e inteligibilidad del mal.

  7. Mal radical e psicologia moral em Kant segundo John Rawls

    OpenAIRE

    Aguinaldo Pavão

    2013-01-01

    http://dx.doi.org/10.5007/1677-2954.2013v12n1p101Em suas Lectures on the History of Moral Philosophy, Rawls esposa a interpretação de que Kant teria se comprometido, sobretudo na Fundamentação, com o que ele chama, tendo Agostinho como inspiração, de “psicologia moral maniqueísta”. Esse flerte inicial acabaria, porém, sendo abandonado, na Religião, em favor de uma “psicologia moral agostiniana”. Essa psicologia atribui exclusivamente à liberdade do arbítrio a fonte do mal moral e repele a ide...

  8. The malQ gene is essential for starch metabolism in Streptococcus mutans

    Directory of Open Access Journals (Sweden)

    Yutaka Sato

    2013-08-01

    Full Text Available Background: The malQ and glgP genes, respectively, annotated as putative 4-α-glucanotransferase and putative glycogen phosphorylase are located with a 29 nucleotide overlap on the Streptococcus mutans genome. We found that the glgP gene of this organism was induced with maltose, and the gene likely constituted an operon with the upstream gene malQ. This putative operon was negatively regulated with the malR gene located upstream from the malQ gene and a MalR-binding consensus sequence was found upstream of the malQ gene. S. mutans is not able to catabolize starch. However, this organism utilizes maltose degraded from starch in the presence of saliva amylase. Therefore, we hypothesized that the MalQ/GlgP system may participate in the metabolism of starch-degradation products. Methods: A DNA fragment amplified from the malQ or glgP gene overexpressed His-tagged proteins with the plasmid pBAD/HisA. S. mutans malQ and/or glgP mutants were also constructed. Purified proteins were assayed for glucose-releasing and phosphorylase activities with appropriate buffers containing maltose, maltotriose, maltodextrin, or amylodextrin as a substrate, and were photometrically assayed with a glucose-6-phosphate dehydrogenase–NADP system. Results: Purified MalQ protein released glucose from maltose and maltotriose but did not from either maltodextrin or amylodextrin. The purified GlgP protein did not exhibit a phosphorylase reaction with maltose or maltotriose but generated glucose-1-phosphate from maltodextrin and amylodextrin. However, the GlgP protein released glucose-1-phosphate from maltose and maltotriose in the presence of the MalQ protein. In addition, the MalQ enzyme activity with maltose released not only glucose but also produced maltooligosaccharides as substrates for the GlgP protein. Conclusion: These results suggest that the malQ gene encodes 4-α-glucanotransferase but not α-1,4-glucosidase activity. The malQ mutant could not grow in the

  9. Konstrukce malé CNC frézky

    OpenAIRE

    Jagoš, Roman

    2012-01-01

    Tato diplomová práce se zabývá stavbou malých CNC frézovacích strojů, a porovnáním CNC stolních frézek na světovém trhu. Dále je provedeno konstrukční řešení malé CNC frézky na základě využití současných a moderních trendů, používaných ve stavbě výrobních strojů. This master´s thesis deals with design of small CNC milling machines and comparing CNC tabletop milling machines in the world market. It is also done design of small CNC milling machine through the use of contemporary and modern t...

  10. (VI) from water by micro-alloyed aluminium composite (MAlC)

    African Journals Online (AJOL)

    driniev

    2004-07-03

    Jul 3, 2004 ... This paper deals with Cr(VI) ion removal from water, by micro-alloyed aluminium composite (MAlC), under flow conditions. In a water environment the MAlC acts as a strong reducing agent. Dissolving it in water is accompanied by the generation of Al(III) ions and reduction of water to H2, with OH– ions.

  11. Characterization of different crystal forms of the alpha-glucosidase MalA from Sulfolobus solfataricus

    DEFF Research Database (Denmark)

    Ernst, Heidi Asschenfeldt; Willemoës, Martin; Lo Leggio, Leila

    2005-01-01

    MalA is an alpha-glucosidase from the hyperthermophilic archaeon Sulfolobus solfataricus. It belongs to glycoside hydrolase family 31, which includes several medically interesting alpha-glucosidases. MalA and its selenomethionine derivative have been overproduced in Escherichia coli...

  12. MAL/VIP17, a New Player in the Regulation of NKCC2 in the Kidney

    Science.gov (United States)

    Rizzo, Federica; Procino, Giuseppe; Basco, Davide; Valenti, Giovanna; Forbush, Biff; Schaeren-Wiemers, Nicole; Caplan, Michael J.; Svelto, Maria

    2010-01-01

    The renal-specific Na+-K+-2Cl− cotransporter (NKCC2) is the major salt transport pathway of the apical membrane of the mammalian thick ascending limb of Henle's loop. Here, we analyze the role of the tetraspan protein myelin and lymphocytes-associated protein (MAL)/VIP17 in the regulation of NKCC2. We demonstrated that 1) NKCC2 and MAL/VIP17 colocalize and coimmunoprecipitate in Lilly Laboratories cell porcine kidney cells (LLC-PK1) as well as in rat kidney medullae, 2) a 150-amino acid stretch of NKCC2 C-terminal tail is involved in the interaction with MAL/VIP17, 3) MAL/VIP17 increases the cell surface retention of NKCC2 by attenuating its internalization, and 4) this coincides with an increase in cotransporter phosphorylation. Interestingly, overexpression of MAL/VIP17 in the kidney of transgenic mice results in cysts formation in distal nephron structures consistent with the hypothesis that MAL/VIP17 plays an important role in apical sorting or in maintaining the stability of the apical membrane. The NKCC2 expressed in these mice was highly glycosylated and phosphorylated, suggesting that MAL/VIP17 also is involved in the stabilization of NKCC2 at the apical membrane in vivo. Thus, the involvement of MAL/VIP17 in the activation and surface expression of NKCC2 could play an important role in the regulated absorption of Na+ and Cl− in the kidney. PMID:20861303

  13. Silencing the major apple allergen Mal d 1 by using the RNA interference approach

    NARCIS (Netherlands)

    Gilissen, L.J.W.J.; Bolhaar, S.T.H.P.; Matos, C.I.; Rouwendal, G.J.A.; Boone, M.J.; Krens, F.A.; Zuidmeer, L.; Leeuwen, van A.; Akkerdaas, J.H.; Hoffmann-Sommergruber, K.; Knulst, A.C.; Bosch, H.J.; Weg, van de W.E.; Ree, van R.

    2005-01-01

    BACKGROUND: Apple allergy is dominated by IgE antibodies against Mal d 1 in areas where birch pollen is endemic. Apples with significantly decreased levels of Mal d 1 would allow most patients in these areas to eat apples without allergic reactions. OBJECTIVE: The aim of this study was to inhibit

  14. 9. Mal. Aceleración y parálisis: a vueltas con la «banalidad del mal»

    OpenAIRE

    Sánchez Capdequí, Celso

    2011-01-01

    Este trabajo pretende probar el alcance explicativo de las claves hermenéuticas de la banalidad del mal para dar cuenta de los avatares de ciertas tendencias de la sociedad contemporánea. La citada expresión puede ofrecer pautas para abordar las expresiones del mal entre nosotros y entender los desafíos y los negros augurios de nuestro tiempo

  15. Epigenetic silencing of MAL, a putative tumor suppressor gene, can contribute to human epithelium cell carcinoma

    Directory of Open Access Journals (Sweden)

    Zhang Jun

    2010-11-01

    Full Text Available Abstract Background To identify new and useful candidate biomarkers in head and neck squamous cell carcinoma (HNSCC, we performed a genome-wide survey and found that Myelin and lymphocyte-associated protein (MAL was a gene that was markedly down-regulated in HNSCC. Hence, we investigated the mechanism of MAL silencing and the effects of MAL on the proliferation, invasion, and apoptotic potential in HNSCC. Results MAL was significantly down-regulated in 91.7% of HNSCC specimens at the mRNA level as compared with adjacent normal tissues (P = 0.0004. Moreover, the relative transcript levels of the MAL gene were remarkably decreased by five-fold in nine HNSCC cell lines as compared with normal head and neck epithelium cells. MAL gene expression was restored in 44%, 67%, and 89% in HNSCC cell lines treated with TSA, 5-Aza-dC, and TSA plus 5-Aza-dC, respectively. Furthermore, bisulfate-treated DNA sequencing demonstrated that the two CpG islands (that is, M1 and M2 located in MAL promoter region were completely methylated in the HNSCC cell lines (CpG methylated ratio was more than 90%, and only one CpG island (that is, M1 was partially methylated in HNSCC tissues (CpG methylated ratio between 20% and 90%. A significant reduction in cell proliferation and a change in the cell cycle profile were also observed in MAL transfectants. Matrigel assay demonstrated that the invasiveness of HNSCC cells significantly decreased. A significant increase in the population of apoptotic cells was observed in MAL transfected cells. The exogenous expression of the MAL gene suppressed malignant phenotypes, while the cell death induced by MAL gene transfer was a result of apoptosis as demonstrated by the induction of cleavage of the poly (that is, ADP-ribose polymerase. Additionally, tumor growth was suppressed in cells expressing MAL as compared with cells not expressing MAL. Conclusion Our data suggest that the epigenetic inactivation of MAL, as a candidate tumor

  16. O mal, sentido e dito Badness felt and spoken

    Directory of Open Access Journals (Sweden)

    Daniel Delouya

    2005-08-01

    Full Text Available O questionamento por que o mal é tão antigo quanto a linguagem e a humanidade. A definição e a identificação do mal com o outro constituem o eixo mais conhecido nas ocupações filosóficas e psicanalíticas. As inabilidades do ser humano, desde os inícios da vida, em lidar com as intensidades que se abatem sobre ele de dentro e de fora, e que resultam no que se denomina de trauma, são certamente os fatores da apreensão do mal e sua identificação com o outro. Entretanto, o trauma institui também o outro na origem do próprio desejo e como guia para a própria linguagem. O outro se engaja nesta empreitada pelo apelo imanente ao trauma e ao estado de desamparo do sujeito. Pretendemos "puxar" um dos fios deste arranjo paradoxal na obra freudiana, examinando sua atual relevância no cenário social e político, também a partir de obras pós-freudianas.The questioning is why badness is as old as humanity and language. The definition and identification of badness with the Other constitute one of the main known axes around which philosophical and psychoanalytical thoughts were fabricated. The helplessness of the newborn human being, his inability to deal with the outer and inner intensities and exigencies, that is, the trauma impact of existence, is certainly one of the main factors for badness conception and the perception of its origin in the other. However, psychoanalysis shows us beyond doubt that the other is also the traumatic source of the human desire and language. The other is called to exercise these functions by the immanent necessities of the original traumatic human condition. We examine some aspects of this paradox complex following its indications in the first Freudian works and relating it to post-Freudian works and its relation with the contemporary scenario

  17. Sector Switching

    DEFF Research Database (Denmark)

    Newman, Carol; Rand, John; Tarp, Finn

    Much of the literature on industry evolution has found firm dynamics to be an important source of sector-level productivity growth. In this paper, we ask whether the delineation of entry and exit firms matters in assessing the impact of firm turnover. Using detailed firm level data from Vietnam, ...

  18. An ecosystem approach to malaria control in an urban setting Uma abordagem ecossistêmica ao controle da malária em contexto urbano

    Directory of Open Access Journals (Sweden)

    Gabriel Carrasquilla

    2001-01-01

    Full Text Available We conducted a research project aimed at strengthening local government and the community for a sustainable malaria control strategy. The project began with a baseline diagnosis of malaria prevalence, a KAP survey, entomology, and health services delivery, after which an epidemiological study was performed to identify risk factors associated with malaria, thereafter used to plan intervention measures. A program evaluation was conducted five years later. By using an ecosystem approach to reanalyze data, this paper discusses how malaria arises from a complex interaction of cultural, economic, ecological, social, and individual factors. Intervention measures require an intersectorial and transdisciplinary approach that does not exist at the moment. Health sector leadership is limited, and there is no true community participation. Implications for research, including the use of qualitative and quantitative methods, study design, and complexity of data analysis are discussed. Finally, implications for malaria control are discussed, stressing the differences between the ecosystem and integrated disease control approaches.Os autores implementaram um projeto de pesquisa voltado ao fortalecimento do governo local e da comunidade com vistas à estratégia sustentável de controle da malária. O projeto iniciou com diagnóstico prévio, incluindo prevalência da malária, entomologia, KAP (conhecimentos, atitudes e práticas e oferta de serviços de saúde; a seguir, realizou-se inquérito epidemiológico para identificar fatores de risco associados à malária e a escolha de medidas de intervenção adequadas. O programa foi avaliado após cinco anos. Ao adotar a abordagem ecossistêmica para re-analisar os dados, o artigo discute como a malária surge a partir da interação complexa entre fatores culturais, econômicos, ecológicos, sociais e individuais. Medidas de intervenção exigem abordagem intersetorial e transdisciplinar ainda não existente. A

  19. Mal radical e psicologia moral em Kant segundo John Rawls

    Directory of Open Access Journals (Sweden)

    Aguinaldo Pavão

    2013-07-01

    Full Text Available http://dx.doi.org/10.5007/1677-2954.2013v12n1p101Em suas Lectures on the History of Moral Philosophy, Rawls esposa a interpretação de que Kant teria se comprometido, sobretudo na Fundamentação, com o que ele chama, tendo Agostinho como inspiração, de “psicologia moral maniqueísta”. Esse flerte inicial acabaria, porém, sendo abandonado, na Religião, em favor de uma “psicologia moral agostiniana”. Essa psicologia atribui exclusivamente à liberdade do arbítrio a fonte do mal moral e repele a ideia de que o mal teria como causa nossa natureza desiderativa ou, até mesmo, social. Pode-se afirmar que, ao fazer uso da expressão “psicologia moral agostiniana”, Rawls apenas chama a atenção, com outro nome, para o que, mais consagradamente, tem sido chamado, a partir de Allison, de tese da incorporação. Esse parece um ponto incontroverso, ou majoritariamente aceito pelos comentaristas de Kant. Não me parece ser o caso, porém, da presença na filosofia moral de Kant do que Rawls chama de psicologia moral maniqueísta. Tal psicologia afirma a existência de dois eus, um bom, que temos à medida que pertencemos ao mundo inteligível, e outro mau, que possuímos como seres do mundo sensível. Rawls corretamente assinala as dificuldades que, de imediato, emergem a partir da psicologia moral maniqueísta, nomeadamente a relacionada à teoria do mal moral em geral e, correspondentemente, à compreensão da responsabilidade moral.  O objetivo do artigo será discutir se Rawls tem razão em atribuir ao pensamento moral de Kant na Fundamentação essa tal psicologia moral maniqueísta. Defenderei que a leitura de Rawls, em seus aspectos mais gerais, é procedente. Sustentarei, porém, que certas considerações que Rawls faz sobre o mundo inteligível e o mundo sensível, especialmente sobre sua possível inoperância, ou abandono dessa distinção na Religião, não merecem acolhimento pleno. Também advogarei que a leitura de Rawls

  20. Sectoral Innovation Watch Space and Aeronautics Sectors. Final sector report

    NARCIS (Netherlands)

    Giessen, A.M. van der

    2011-01-01

    The space and aeronautics sectors are high-technology sectors and belong to the most innovative sectors in Europe1. Analysis of CIS4 data shows that the space and aeronautics sectors continue to be very innovative. 85% of the firms is engaged in intramural R&D. Total R&D expenditures are between 21%

  1. La 'cuestion' del mal y la Modernidad. A proposito de una lectura desde Walter Benjamin

    National Research Council Canada - National Science Library

    Hincapie Garcia, Alexander

    2014-01-01

    .... Dentro de las tesis que se proponen es que el mal no puede estudiarse partiendo hacia la busqueda de sus origenes, sino inscribiendolo dentro de unas coordenadas especificas en terminos historicos y culturales...

  2. The regulatable MAL32 promoter in Saccharomyces cerevisiae: characteristics and tools to facilitate its use.

    Science.gov (United States)

    Meurer, Matthias; Chevyreva, Veronika; Cerulus, Bram; Knop, Michael

    2017-01-01

    Here we describe a set of tools to facilitate the use of maltose and the MAL32 promoter for regulated gene expression in yeast, alone or in combination with the GAL1 promoter. Using fluorescent protein reporters we find that under non-inducing conditions the MAL32 promoter exhibits a low basal level of expression, similar to the GAL1 promoter, and that both promoters can be induced independently of each other using the respective sugars, maltose and galactose. While their repression upon glucose addition is immediate and complete, we found that the MAL32 and GAL1 promoters each exhibit distinct induction kinetics. A set of plasmids is available to facilitate the application of the MAL32 promoter for chromosomal modifications using PCR targetting and for plasmid based gene expression. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  3. "Kevad uhkelt sammub mal kui jumalanna..." : [luuletused] / Ljubov Dergatshova ; tlk. Arvo Valton

    Index Scriptorium Estoniae

    Dergatshova, Ljubov

    2006-01-01

    Sisu: "Kevad uhkelt sammub mal kui jumalanna..." ; "Maga, pojake, maga mu päike..." ; "Mis kaunis õhtu! Lumi tahke..." ; "Raskel tunnil sirutab kes käe...". Luuletused paralleelselt ersa ja eesti keeles

  4. Hypermethylated MAL gene – a silent marker of early colon tumorigenesis

    Directory of Open Access Journals (Sweden)

    Kallioniemi Anne

    2008-03-01

    Full Text Available Abstract Background Tumor-derived aberrantly methylated DNA might serve as diagnostic biomarkers for cancer, but so far, few such markers have been identified. The aim of the present study was to investigate the potential of the MAL (T-cell differentiation protein gene as an early epigenetic diagnostic marker for colorectal tumors. Methods Using methylation-specific polymerase chain reaction (MSP the promoter methylation status of MAL was analyzed in 218 samples, including normal mucosa (n = 44, colorectal adenomas (n = 63, carcinomas (n = 65, and various cancer cell lines (n = 46. Direct bisulphite sequencing was performed to confirm the MSP results. MAL gene expression was investigated with real time quantitative analyses before and after epigenetic drug treatment. Immunohistochemical analysis of MAL was done using normal colon mucosa samples (n = 5 and a tissue microarray with 292 colorectal tumors. Results Bisulphite sequencing revealed that the methylation was unequally distributed within the MAL promoter and by MSP analysis a region close to the transcription start point was shown to be hypermethylated in the majority of colorectal carcinomas (49/61, 80% as well as in adenomas (45/63, 71%. In contrast, only a minority of the normal mucosa samples displayed hypermethylation (1/23, 4%. The hypermethylation of MAL was significantly associated with reduced or lost gene expression in in vitro models. Furthermore, removal of the methylation re-induced gene expression in colon cancer cell lines. Finally, MAL protein was expressed in epithelial cells of normal colon mucosa, but not in the malignant cells of the same type. Conclusion Promoter hypermethylation of MAL was present in the vast majority of benign and malignant colorectal tumors, and only rarely in normal mucosa, which makes it suitable as a diagnostic marker for early colorectal tumorigenesis.

  5. MAL Is a Regulator of the Recruitment of Myelin Protein PLP to Membrane Microdomains.

    Directory of Open Access Journals (Sweden)

    Marjolein Bijlard

    Full Text Available In oligodendrocytes (OLGs, an indirect, transcytotic pathway is mediating transport of de novo synthesized PLP, a major myelin specific protein, from the apical-like plasma membrane to the specialized basolateral-like myelin membrane to prevent its premature compaction. MAL is a well-known regulator of polarized trafficking in epithelial cells, and given its presence in OLGs it was therefore of interest to investigate whether MAL played a similar role in PLP transport in OLGs, taking into account its timely expression in these cells. Our data revealed that premature expression of mCherry-MAL in oligodendrocyte progenitor cells interfered with terminal OLG differentiation, although myelin membrane formation per se was not impaired. In fact, also PLP transport to myelin membranes via the cell body plasma membrane was unaffected. However, the typical shift of PLP from TX-100-insoluble membrane domains to CHAPS-resistant, but TX-100-soluble membrane domains, seen in the absence of MAL expression, is substantially reduced upon expression of the MAL protein. Interestingly, not only in vitro, but also in developing brain a strongly diminished shift from TX-100 resistant to TX-100 soluble domains was observed. Consistently, the MAL-expression mediated annihilation of the typical membrane microdomain shift of PLP is also reflected by a loss of the characteristic surface expression profile of conformation-sensitive anti-PLP antibodies. Hence, these findings suggest that MAL is not involved in vesicular PLP trafficking to either the plasma membrane and/or the myelin membrane as such. Rather, we propose that MAL may regulate PLP's distribution into distinct membrane microdomains that allow for lateral diffusion of PLP, directly from the plasma membrane to the myelin membrane once the myelin sheath has been assembled.

  6. Profil du mal de pott en consultation rhumatologique a Lome (Togo ...

    African Journals Online (AJOL)

    Conclusion : La fréquence du mal de Pott est le reflet du sous-développement et d'insuffisance de l'hygiène en Afrique Noire. Elle demeure une préoccupation en dépit de la transition démographique dont est satellite la transition épidémiologique. Mots clés : Mal de Pott ; Spondylodiscite ; Tuberculose ; Afrique Noire.

  7. The MAL-ED cohort study in Mirpur, Bangladesh.

    Science.gov (United States)

    Ahmed, Tahmeed; Mahfuz, Mustafa; Islam, Md Munirul; Mondal, Dinesh; Hossain, Md Iqbal; Ahmed, Am Shamsir; Tofail, Fahmida; Gaffar, Sm Abdul; Haque, Rashidul; Guerrant, Richard L; Petri, William A

    2014-11-01

    The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) study site in Bangladesh is located in the capital city of Dhaka in an urban slum that has one of the highest population densities in the world. The site is in the Bauniabadh area of Mirpur, Dhaka. A typical squatter settlement, the average family size of households in Mirpur Bauniabadh is 4.5, with 48% females. About 20% of households have a monthly income of only US$62. About 30% of mothers never attended school, and only 3% obtained secondary school education. The majority of the people are day laborers, garment workers, and transport workers. About 72% of caregivers always wash their hands after helping the child defecate and 6.6% never wash their hands. The diarrheal attack rate for Mirpur is 4.69 episodes per child per year. The study site is representative of a typical urban slum of Dhaka city in terms of demographics, socioeconomic status, and general health indicators. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  8. Sobre el mal radical. Ensayo de la heterodoxia kantiana

    Directory of Open Access Journals (Sweden)

    Gómez Caffarena, José

    2004-06-01

    Full Text Available The kantian theory of a «radical evil inhabiting human nature» contrasts with a general anthropological optimistic tenor perceptible in kantian philosophy. It meant a significant turning point in the often too superficial optimistic trends of the Enlightenment. Hut its literal sense (appealing to an act of pre-individual freedom has an obvious difficulty. The present paper proposes an heterodox interpretation, which would avoid the difficulty, although so losing part of the tempting enigmatic reach of the kantian proposal.

    La teoría del «mal radical en la naturaleza humana», expuesta por Kant en La religión dentro de los límites de la mera razón, hace contraste con el optimismo antropológico que empapa el Criticismo. Constituyó, sin duda, una importante denuncia frente a la banalidad de muchos optimismos ilustrados. Pero su letra (acto de libertad pre-individual tiene una obvia dificultad. El artículo propone una reinterpretación que la evitaría, aunque desdramatizando un tanto el tentador alcance enigmático de la propuesta kantiana.

  9. Sobre a psicogênese do "mal de engasgo"

    Directory of Open Access Journals (Sweden)

    Durval Marcondes

    1947-06-01

    Full Text Available O A. ressalta o aspecto psicológico da etiologia do cardiospasmo ou mal de engasgo, assunto até agora não abordado nos meios científicos brasileiros. Sem pretender afastar outros elementos causais que tenham sido, porventura, verificados e que poderão, talvez, agir concomitantemente, o A. é de opinião que o mal de engasgo é um disturbio funcional condicionado psìquicamente, cujas conseqüências se tornam irreversíveis depois de certo tempo. As conclusões apresentadas baseiam-se no material fornecido por pacientes em tratamento psicanalítico que apresentam fenômenos disfágicos, e por vários casos das clínicas de orientação infantil entre cujos problemas se incluem, além da dificuldade de engulir, a anorexia e a bulimia. Com respeito às atividades emocionais típicas que formam o substrato psicológico do mal de engasgo, o ponto fundamental está em que êste representa um compromisso, expresso ao nível oral, entre tendências passivo-receptivas e ativo-expulsivas. A essa situação psíquica correspondem condições de ambiente, atuais ou pretéritas, que, de modo contraditório, favorecem uma atitude de dependência infantil, ao mesmo tempo que acarretam repetidas frustrações. Trata-se, em geral, de mães dominadoras que, enquanto superprotegem a criança, agem para com ela com demasiado rigor. A superproteção centraliza-se sobretudo no que se refere aos alimentos, que se investem, assim, de grande significado emocional. O A. apresenta o resumo de uma observação clínica que apoia seu ponto de vista. Também a anorexia e a bulimia, em seu substrato psicodinâmico, estão relacionadas com o problema do apego e da emancipação e giram em torno da pessoa da mãe e da função alimentar. A solução do conflito faz-se, porém, num dos casos, pela rejeição do alimento e, noutro, pela avidez. O mal de engasgo constitui o meio têrmo entre os dois extremos. Existem, igualmente, nas neuroses gástricas e em sua conseq

  10. BAYT AL-MAL AND ITS ROLE IN ECONOMIC DEVELOPMENT: A CONTEMPORARY STUDY

    Directory of Open Access Journals (Sweden)

    Md. Habibur RAHMAN

    2015-08-01

    Full Text Available Bayt al-Mal, known as the public treasury of Islamic state, was established by the Prophet-may peace be upon Him- and then it was further extended and expanded by Abu Bakr and Umar, who succeeded the Prophet as the Caliph of the Islamic state. It is the state treasury that keeps the sole authority to mobilize the funds of the state. This paper aims to study the potential role and contribution of Bayt al-Mal to economic development in the contemporary context. It will be a qualitative paper and the analytical and descriptive method will be applied. Historically Bayt al-Mal played a great role in the distribution and redistribution of funds. It performed the function that is similar to the function of the ministry of finance at present. It also carried out the jobs of central bank in terms of monitoring, issuing currencies, controlling credits and so forth. Through discussing its sources and expenditures the paper posits that the role of Bayt al-Mal can be revived and accelerated by, for example, providing small-medium funds, managing Zakah and awqaf, channeling the funds, issuing various financial instruments and so forth. Bayt al-Mal could have a significant role in the eradication of poverty from the state. The paper concludes that with the rapid growth of Islamic finance, the Bayt al-Mal can be utilized in parallel in order to have a robust economic development.

  11. Sectoral assessments

    Energy Technology Data Exchange (ETDEWEB)

    Callaway, J.M.; Fenhann, J.; Gorham, R.; Makundi, W.; Sathaye, J.

    1999-09-01

    This publication contains five papers that were written as a part of the GEF project, The Economics of Greenhouse Gas Limitations. The main goal of the project was to assess the greenhouse gas reductions and incremental costs of mitigation option sin Ecuador, Argentina, Senegal, Mauritius, Vietnam, Indonesia, Estonia and Hungary. In addition, regional studies were conducted for the Andean Pact nations and Southern Africa to assess various aspects of regional co-operation in reducing greenhouse gas emissions. The GEF study also involved the development of a methodological framework for climate change assessment, with a special emphasis on developing countries. These guidelines have been published in a separate document, Economics of Greenhouse Gas Limitations: Methodological Guidelines. The papers in this publication focus on various methodological and policy aspects of greenhouse gas mitigation at the sectoral level, and are outgrowth of work performed on other parts of the GEF project. (au)

  12. Assessment of allelic diversity in intron-containing Mal d 1 genes and their association to apple allergenicity

    Directory of Open Access Journals (Sweden)

    Bolhaar Suzanne THP

    2008-11-01

    Full Text Available Abstract Background Mal d 1 is a major apple allergen causing food allergic symptoms of the oral allergy syndrome (OAS in birch-pollen sensitised patients. The Mal d 1 gene family is known to have at least 7 intron-containing and 11 intronless members that have been mapped in clusters on three linkage groups. In this study, the allelic diversity of the seven intron-containing Mal d 1 genes was assessed among a set of apple cultivars by sequencing or indirectly through pedigree genotyping. Protein variant constitutions were subsequently compared with Skin Prick Test (SPT responses to study the association of deduced protein variants with allergenicity in a set of 14 cultivars. Results From the seven intron-containing Mal d 1 genes investigated, Mal d 1.01 and Mal d 1.02 were highly conserved, as nine out of ten cultivars coded for the same protein variant, while only one cultivar coded for a second variant. Mal d 1.04, Mal d 1.05 and Mal d 1.06 A, B and C were more variable, coding for three to six different protein variants. Comparison of Mal d 1 allelic composition between the high-allergenic cultivar Golden Delicious and the low-allergenic cultivars Santana and Priscilla, which are linked in pedigree, showed an association between the protein variants coded by the Mal d 1.04 and -1.06A genes (both located on linkage group 16 with allergenicity. This association was confirmed in 10 other cultivars. In addition, Mal d 1.06A allele dosage effects associated with the degree of allergenicity based on prick to prick testing. Conversely, no associations were observed for the protein variants coded by the Mal d 1.01 (on linkage group 13, -1.02, -1.06B, -1.06C genes (all on linkage group 16, nor by the Mal d 1.05 gene (on linkage group 6. Conclusion Protein variant compositions of Mal d 1.04 and -1.06A and, in case of Mal d 1.06A, allele doses are associated with the differences in allergenicity among fourteen apple cultivars. This information

  13. Metabolic and functional connectivity changes in mal de debarquement syndrome.

    Directory of Open Access Journals (Sweden)

    Yoon-Hee Cha

    Full Text Available Individuals with mal de debarquement syndrome (MdDS experience a chronic illusion of self-motion triggered by prolonged exposure to passive motion, such as from sea or air travel. The experience is one of rocking dizziness similar to when the individual was originally on the motion trigger such as a boat or airplane. MdDS represents a prolonged version of a normal phenomenon familiar to most individuals but which persists for months or years in others. It represents a natural example of the neuroplasticity of motion adaptation. However, the localization of where that motion adaptation occurs is unknown. Our goal was to localize metabolic and functional connectivity changes associated with persistent MdDS.Twenty subjects with MdDS lasting a median duration of 17.5 months were compared to 20 normal controls with (18F FDG PET and resting state fMRI. Resting state metabolism and functional connectivity were calculated using age, grey matter volume, and mood and anxiety scores as nuisance covariates.MdDS subjects showed increased metabolism in the left entorhinal cortex and amygdala (z>3.3. Areas of relative hypometabolism included the left superior medial gyrus, left middle frontal gyrus, right amygdala, right insula, and clusters in the left superior, middle, and inferior temporal gyri. MdDS subjects showed increased connectivity between the entorhinal cortex/amygdala cluster and posterior visual and vestibular processing areas including middle temporal gyrus, motion sensitive area MT/V5, superior parietal lobule, and primary visual cortex, while showing decreased connectivity to multiple prefrontal areas.These data show an association between resting state metabolic activity and functional connectivity between the entorhinal cortex and amygdala in a human disorder of abnormal motion perception. We propose a model for how these biological substrates can allow a limited period of motion exposure to lead to chronic perceptions of self-motion.

  14. Contribución al conocimiento de los malófagos (Phthiraptera, Amblycera, Ischnocera de aves peruanas. Parte 1

    Directory of Open Access Journals (Sweden)

    Luis A. Gomez-Puerta

    2015-12-01

    Full Text Available En el presente trabajo se reporta nueve especies de malófagos colectados de aves peruanas. Dos malófagos Amblycera: Heteromenopon laticapitis y Menacanthus pici, así como siete malófagos Ischnocera: Alcedoffula theresae, Brueelia brunneinucha, Chelopistes meleagridis, Columbicola columbae, Paragoniocotes aratingae, Penenirmus jungens y Saemundssonia (Saemundssonia lari, fueron determinados mediante el diagnóstico morfológico. Se realiza una breve descripción de cada malófago, así como la discusión de sus hospederos y distribución.

  15. Interaction of PLP with GFP-MAL2 in the human oligodendroglial cell line HOG.

    Directory of Open Access Journals (Sweden)

    Raquel Bello-Morales

    Full Text Available The velocity of the nerve impulse conduction of vertebrates relies on the myelin sheath, an electrically insulating layer that surrounds axons in both the central and peripheral nervous systems, enabling saltatory conduction of the action potential. Oligodendrocytes are the myelin-producing glial cells in the central nervous system. A deeper understanding of the molecular basis of myelination and, specifically, of the transport of myelin proteins, will contribute to the search of the aetiology of many dysmyelinating and demyelinating diseases, including multiple sclerosis. Recent investigations suggest that proteolipid protein (PLP, the major myelin protein, could reach myelin sheath by an indirect transport pathway, that is, a transcytotic route via the plasma membrane of the cell body. If PLP transport relies on a transcytotic process, it is reasonable to consider that this myelin protein could be associated with MAL2, a raft protein essential for transcytosis. In this study, carried out with the human oligodendrocytic cell line HOG, we show that PLP colocalized with green fluorescent protein (GFP-MAL2 after internalization from the plasma membrane. In addition, both immunoprecipitation and immunofluorescence assays, indicated the existence of an interaction between GFP-MAL2 and PLP. Finally, ultrastructural studies demonstrated colocalization of GFP-MAL2 and PLP in vesicles and tubulovesicular structures. Taken together, these results prove for the first time the interaction of PLP and MAL2 in oligodendrocytic cells, supporting the transcytotic model of PLP transport previously suggested.

  16. Maleficencia y la banalidad del mal: una reflexión bioética

    Directory of Open Access Journals (Sweden)

    Miguel Kottow

    2014-01-01

    Full Text Available La bioética resalta la prominencia de la no maleficencia, sea como principio o como fundamentos de la moral común, pero no ha desarrollado una reflexión más profunda sobre el mal. El presente trabajo indaga acaso el mal radical —que decreta la superfluidad de lo humano ejercida, recurriendo a biopolíticas tanatológicas (“hacer vivir y dejar morir” según la fórmula original de Foucault— y la banalidad del mal entendida como maleficencia inexplicable basada en ceguera moral de los perpetradores; ambos pueden coexistir con una bioética que rechaza el mal y requiere la responsabilidad de quienes lo cometen. La conclusión es reconocer que la bioética se opone a toda biopolítica tanatológica y se niega a conceder que la ceguera moral sea excusa para no asumir la responsabilidad de actos maleficentes. La teoría sobre el mal de Arendt es incompatible con la reflexión fundamentada en evaluar actos emprendidos en libertas y responsabilidad.

  17. Formal aspects of vigilance during petit mal paroxysm.

    Science.gov (United States)

    Faber, J

    1975-01-01

    Relationship between amplitude and interval of healthy and epileptic children's alpha activity was investigated. A directly proportional, though non-linear (mostly exponential) correlation was found, i. e. the higher the waves, the wider their are, and vice versa, the lower, the narrower. This is a well-known feature of clinical electroencephalography, representing a good organization of EEG elements and, in terms of physiology, suggesting good "co-operation" of the recruitment process excitation and inhibition. Low interval values are matched by equally low amplitude values while inhibition is adequate. At higher interval values, amplitude is seen rising rapidly, inhibition is inadequate resulting in "paroxysmal" alpha activity which is occasionally found assuming the nature of spike and slow wave activity. The appearance of such principal changes in the recruitment process is abrupt, but a certain part of the changes often fails to manifest itself in the EEG curve. Epileptic children's alpha activity has a relatively higher amplitude, slower rhythm and a more regular regulation of amplitudes and intervals as well as that of their ratio. This is in line with the tendency toward hypersynchrony of EEG elements in epileptics. Epileptic spike and wave activity has an opposite sense of regulation as to the relationship of spike amplitudes and intervals, the principle being: the higher the spikes, the shorter the intervals between them. Apart from frequency, amplitude and angular velocity, that is another substantial difference between alpha activity physiological synchronization in vigilance and pathological spike hypersynchronization in petit mal seizure. Changes in vigilance seem to be in agreement with this phenomenon. The nature of recruitment process regulation (given in type of function) appears to be very stable, often remaining unchanged even under pathological conditions. Thus e. g. aplha wave recruitment during vigilance and spike recruitment during seizure

  18. Glucose and maltose metabolism in MIG1-disrupted and MAL-constitutive strains of Saccharomyces cerevisiae

    DEFF Research Database (Denmark)

    Klein, Christopher; Olsson, Lisbeth; Rønnow, B

    1997-01-01

    The alleviation of glucose control of maltose metabolism brought about by MIG1 disruption was compared to that by MAL overexpression in a haploid Saccharomyces cerevisiae strain. The sugar consumption profiles during cultivation of the wild type, single transformants and a double transformant...... in a mixed glucose-maltose medium revealed that the MAL-constitutive strains were more alleviated than the single MIG1-disrupted transformant. While all transformants exhibited higher maximum specific growth rates (0.24-0.25 h(-1)) in glucose-maltose mixtures than the wild type strain (0.20 h(-1)), the MAL......-constitutive transformants grew even faster (0.27-0.30 h(-1)) in pure glucose medium than the wild type strain (0.24 h(-1))....

  19. Estado de mal epiléptico en pediatría

    Directory of Open Access Journals (Sweden)

    Jorge Malagón Valdez

    2013-09-01

    Full Text Available El estado de mal epiléptico es una emergencia médica en la cual se presentan crisis epilépticas por 30 minutos o más de actividad continua, o bien dos o más crisis consecutivas sin recuperación completa de la conciencia entre las mismas. Actualmente se considera que una crisis epiléptica convulsiva o no, que dure más de 5 minuto se deberá considerar un estado de mal epiléptico. Se han utilizado diversos fármacos para el tratamiento de esta patología y sus secuelas. Hay un consenso generalizado en que se debe realizar un manejo agresivo para disminuir su morbi-mortalidad, sin olvidarse que la causa del estado de mal es importante para su manejo, control y sus secuelas.

  20. El Mal y la subjetivación política

    Directory of Open Access Journals (Sweden)

    Jairo H. Gómez-Esteban

    2014-05-01

    Full Text Available El propósito de este ensayo es retomar el problema del Mal en los diversos modos de subjetivación política. Sus objetivos se sitúan en denunciar cómo las perspectivas afirmativas de la subjetividad escamotean el papel que el Mal cumple en los procesos de subjetivación, y señalar las implicaciones que tiene el Mal en la investigación de subjetividades políticas en un país con un conflicto armado inveterado que mantiene uno de los índices de desigualdad e injusticia social más alto, y cuyos investigadores e investigadoras asumen que la subjetivación política se encuentra únicamente en la participación y la democracia, en la autorregulación y la autonomía, en el reconocimiento y la identidad.

  1. A soberania do mal: Georges Bataille e a inocência culpada da literatura

    Directory of Open Access Journals (Sweden)

    Philippe Joron

    Full Text Available Em seu ensaio crítico sobre La littérature et le mal (1957, Georges Bataille usa todo um arsenal de conceitos e ideias interligadas para dar conta da Soberania do mal em Literatura e, ao mesmo tempo, da soberania da Literatura pelo mal. Com base em pesquisa bibliográfica, o objetivo do estudo aqui proposto será mostrar que esses mesmos conceitos e opções de pensamento já vinham sendo trabalhados em muitos escritos anteriores filosóficos, econômicos e políticos, ou mesmo místicos, que podem formar a base da sociologia heurística do autor. Para Bataille, a Literatura é comunicação. Ela parte de um autor soberano, passa pela servidão de um leitor isolado, e se destina a uma humanidade soberana.

  2. Learn about Smart Sectors

    Science.gov (United States)

    about the Smart Sectors program including: Meaningful Collaboration with Regulated Sectors; Sensible Policies to Improve Environmental Outcomes; Better EPA Practices and Streamlined Operations; Historical Context

  3. Regulatory Information By Sector

    Science.gov (United States)

    Find environmental regulatory, compliance, & enforcement information for various business, industry and government sectors, listed by NAICS code. Sectors include agriculture, automotive, petroleum manufacturing, oil & gas extraction & other manufacturing

  4. Effect of refrigerant mal-distribution in fin-and-tube evaporators on system performance

    DEFF Research Database (Denmark)

    Kærn, Martin Ryhl; Elmegaard, Brian; Larsen, Lars Finn Sloth

    2009-01-01

    the condenser is a dynamic moving boundary model. The evaporator model is a dynamic distributed one-dimensional homogeneous equilibrium model, in order to capture the distribution phenomena. Fin-and-tube heat exchangers usually have a complex circuitry, however the evaporator will be simplified to be two...... straight tubes. The refrigerant mal-distribution is then induced to the evaporator by varying the vapor quality at the inlet to each feeder tube, the pressure drop through each feeder tube and the air-flow across each tube. Finally it is shown that air-flow mal-distribution can be compensated...

  5. La apuesta de Dios : la aporía del mal y el mito de Job

    OpenAIRE

    Gómez Marín, José Antonio

    2016-01-01

    Esta tesis doctoral responde al ansia antigua que produce la realidad del Mal, esa vieja aporía que compromete el criterio filosófico tanto como el teológico o el sociológico y desde esa triple perspectiva el autor ha tratado de resumir las conclusiones proporcionadas por una extensa bibliografía, filtradas, como es lógico, por el criterio propio. Es, en consecuencia, un trabajo ante todo expositivo, pues el objeto de consideración, el Mal, viene rebotando en el pensamiento desde la más profu...

  6. Spatio-temporal analysis of human electroencephalograms: Petit-mal epilepsy

    Science.gov (United States)

    Friedrich, R.; Uhl, C.

    An analysis of multigrid electroencephalograms (EEG) derived from two different persons suffering from petit-mal epilepsy is performed. Using a previously devised method for analyzing spatio-temporal patterns (Uhl, et al., Z. Phys. B 92 (1993) 211-219), we find a suitable mode decomposition of the EEG. Additionally, we are able to extract a three-dimensional dynamical system which describes the dynamics of the patterns as a kind of mode interaction. We show that the spike-wave behavior characteristic for petit-mal epilepsy arising in the dynamical system is related with Sil'nikov-type behavior of the mode dynamics.

  7. Images du mal ou images maléfiques? Les images populaires du Diable chez les chrétiens du Ghana

    NARCIS (Netherlands)

    Meyer, B.

    2008-01-01

    Cet article, qui se concentre sur les images du mal, explore l’écart entre les modes de vision induits d’une part par l’exposition « All About Evil » au Royal Tropical Museum d’Amsterdam, et d’autre part par le cadre chrétien dans lequel apparaissent d’ordinaire les objets ainsi exposés. Tandis que

  8. Maturity and storage influence on the apple (Malus domestica) allergen Mal d 3, a nonspecific lipid transfer protein

    NARCIS (Netherlands)

    Sancho, Ana I.; Foxall, Robert; Rigby, Neil M.; Browne, Thomas; Zuidmeer, Laurian; van Ree, Ronald; Waldron, Keith W.; Mills, E. N. Clare

    2006-01-01

    Consumption of apples can provoke severe allergic reactions, in susceptible individuals, due to the presence of the allergen Mal d 3, a nonspecific lipid transfer protein, found largely in the fruit skin. Levels of Mal d 3 were determined in peel as a function of apple cultivar, position of the

  9. Assessment of allelic diversity in intron-containing Mal d 1 genes and their association to apple allergenicity

    NARCIS (Netherlands)

    Gao, Z.S.; Weg, van de W.E.; Matos, C.; Arens, P.F.P.; Bolhaar, S.T.H.P.; Knulst, A.C.; Li, Y.; Hoffmann-Sommergruber, K.; Gilissen, L.J.W.J.

    2008-01-01

    Background Mal d 1 is a major apple allergen causing food allergic symptoms of the oral allergy syndrome (OAS) in birch-pollen sensitised patients. The Mal d 1 gene family is known to have at least 7 intron-containing and 11 intronless members that have been mapped in clusters on three linkage

  10. Voxel Based Morphometry Alterations in Mal de Debarquement Syndrome.

    Directory of Open Access Journals (Sweden)

    Yoon-Hee Cha

    Full Text Available Mal de debarquement syndrome (MdDS is a disorder of chronic self-motion perception that occurs though entrainment to rhythmic background motion, such as from sea voyage, and involves the perception of low-frequency rocking that can last for months or years. The neural basis of this persistent sensory perception abnormality is not well understood.We investigated grey matter volume differences underlying persistent MdDS by performing voxel-based morphometry on whole brain and pre-specified ROIs in 28 individuals with MdDS and comparing them to 18 age, sex, and handedness matched controls.MdDS participants exhibited greater grey matter volume in the left inferior parietal lobule, right inferior occipital gyrus (area V3v, right temporal pole, bilateral cerebellar hemispheric lobules VIII/IX and left lobule VIIa/VIIb. Grey matter volumes were lower in bilateral inferior frontal, orbitofrontal, pregenual anterior cingulate cortex (pgACC and left superior medial gyri (t = 3.0, p<0.005uncorr. In ROI analyses, there were no volume differences in the middle occipital gyrus (region of V5/MT or parietal operculum 2 (region of the parietoinsular vestibular cortex. Illness duration was positively related to grey matter volume in bilateral inferior frontal gyrus/anterior insula (IFG/AI, right posterior insula, superior parietal lobule, left middle occipital gyrus (V5/MT, bilateral postcentral gyrus, anterior cerebellum, and left cerebellar hemisphere and vermian lobule IX. In contrast, illness duration was negatively related to volume in pgACC, posterior middle cingulate gyrus (MCC, left middle frontal gyrus (dorsolateral prefrontal cortex-DLPFC, and right cerebellar hemispheric lobule VIIIb (t = 3.0, p<0.005uncorr. The most significant differences were decreased volume in the pgACC and increased volume in the left IFG/AI with longer illness duration (qFDRcorr <0.05. Concurrent medication use did not correlate with these findings or have a relationship with

  11. Le mal de Pott: à propos de 82 cas

    Directory of Open Access Journals (Sweden)

    Badr Fedoul

    2011-03-01

    Full Text Available Nous rapportant dans cette étude, les résultats de l’expérience du service de neurochirurgie du CHU Hassan II de Fès dans la prise en charge du mal de pott dans la région de Fès. Il s’agit d’une étude rétrospective de quatre-vingt-deux cas; étalée sur une période de cinq ans (janvier 2002 au décembre 2006. L’objectif de ce travail était d’illustrer les différents aspects épidémiologiques, diagnostiques et thérapeutiques de la localisation vertébrale de la tuberculose dans notre pratique. L'âge moyen de nos patients était de 43,1 ans, avec une légère prédominance féminine (53,82%. La durée d'évolution de la maladie était longue (dix mois en moyenne; ceci est expliquée par la symptomatologie initiale insidieuse faite de rachialgies (98,78% et une admission des patients au stade de complications neurologiques (41,46%. La radiographie standard était réalisée chez tous nos patients, et complétée par la TDM dans 86.58% des cas ce qui a permis de déceler la prédominance de l'atteinte dorsale et lombaire. L'IRM est l'examen de choix, elle était demandée chez tous les malades déficitaires (37,8%.Tous nos patients ont bénéficié d'un traitement antibacillaire associé à une immobilisation du foyer pottique. Une décompression par voie antérieure était réalisée chez 29 patients (35,36 %; alors que la laminectomie n'était pratiquée que chez 5 patients (6.09 %, tandis que l'évacuation de l'abcès de psoas était réalisée chez 25 patients (30,48 %. Le diagnostic de certitude histologique était posé dans 51 cas (62,19%. Les meilleurs résultats étaient obtenus chez les malades opérés par voie antérieure, 26 cas (89,65% de récupération totale et 3 cas (10,34% partielle. L'évolution vers la consolidation et la fusion vertébrale était la règle chez tous nos malades et ceci au bout de 4 à 18 mois après le traitement.

  12. Pengaruh Unsur Alam terhadap Minat Berkunjung Kembali di Mal

    Directory of Open Access Journals (Sweden)

    Riza Septriani Dewi

    2016-12-01

    Full Text Available Pusat perbelanjaan yang berkonsep alam dianggap lebih diminati pengunjung. Penelitian ini mengkaji tentang pengaruh unsur-unsur alam terhadap minat konsumen untuk berkunjung kembali. Variabel yang akan dikaji terdiri dari variabel bebas, yaitu air (diam-bergerak dan vegetasi (tanaman rendah-tanaman tinggi, dan variabel terikat, yaitu persepsi alam dan sikap berkunjung kembali. Penelitian ini menggunakan metode eksperimen stimulus-respon melalui pendekatan kuantitatif dengan prinsip between-subject factorial design. Simulasi gambar digital dari interior pusat perbelanjaan pada 4 kondisi sebagai kombinasi variabel tersebut di atas digunakan sebagai stimulus percobaan, di mana 4 kelompok responden, masing-masing 20 orang, akan menilai stimulus eksperimen dalam kondisi berbeda, atas dasar persepsi alam dan sikap berkunjung kembali. Data eksperimen dihitung dan dianalisa dengan statistik one-way ANOVA. Efek kombinasi variabel air bergerak dan tanaman tinggi ternyata tidak memberikan pengaruh yang signifikan terhadap persepsi alam responden. Efek kombinasi variabel air diam dengan tanaman tinggi tidak memberikan pengaruh yang signifikan terhadap minat responden untuk berkunjung kembali. Namun, efek kombinasi variabel air mengalir dengan tanaman rendah cenderung lebih mengundang persepsi alam yang baik dan minat berkunjung kembali. Hasil eksperimen ini diharapkan dapat menjadi rekomendasi bagi perkembangan ilmu desain dan sebagai salah satu referensi bagi desainer dan pengembang.Kata Kunci: mal; minat berkunjung; persepsi alam; perilaku konsumen.Effects of Natural Elements on Interest to Revisit a MallShopping malls with a natural concept are more attractive to visitors. This study examined the influence of natural interior design elements on client interest to revisit a mall. The assessed elements consisted of independent variables, namely water (still-standing/flowing and vegetation (ground plants/potted plants, and dependent variables, namely nature

  13. Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1

    DEFF Research Database (Denmark)

    Holm, Jens; Ferreras, Mercedes; Ipsen, Henrik

    2011-01-01

    allergen Malus domestica group 1 (Mal d 1). Engineering of the epitope was accomplished by genetic engineering substituting amino acid residues in Mal d 1 differing between Bet v 1 and Mal d 1 within the epitope defined by the mAb BV16. The kinetic parameters characterizing the antibody binding interaction...

  14. Evaluation of the OptiMAL Test for Rapid Diagnosis of Malaria | Ujah ...

    African Journals Online (AJOL)

    This study evaluated the ability of a newly developed rapid test for laboratory diagnosis of malaria. OptiMAL is a rapid test that utilizes a dipstick coated with monoclonal antibodies against the intracellular parasite dehydrogenase (PLDH). The differentiation of Plasmodium species is based on antigenic differences between ...

  15. Synthesis, crystal structure and magnetic properties of [Cu(mal)(abpt ...

    African Journals Online (AJOL)

    Complex 1 consist of a neutral mononuclear [Cu(mal)(abpt)(H2O)] unit and water molecule of crystallization in a distorted square pyramidal coordination sphere, while complex 2 is viewed as being made up of [Cu(sq)(abpt)2] units with the squarato ligand bridging the two copper(II) cations. Variable temperature magnetic ...

  16. MAL Is a Regulator of the Recruitment of Myelin Protein PLP to Membrane Microdomains

    NARCIS (Netherlands)

    Bijlard, Marjolein; de Jonge, Jenny C.; Klunder, Bert; Nomden, Anita; Hoekstra, Dick; Baron, Wia

    2016-01-01

    In oligodendrocytes (OLGs), an indirect, transcytotic pathway is mediating transport of de novo synthesized PLP, a major myelin specific protein, from the apical-like plasma membrane to the specialized basolateral-like myelin membrane to prevent its premature compaction. MAL is a well-known

  17. Preparation of MAl O : Eu2+, Sm3+ (M = Ca, Sr, Ba) Phosphors by ...

    African Journals Online (AJOL)

    NJD

    2007-10-15

    Oct 15, 2007 ... A series of MAl2O4: Eu2+, Sm3+ (M = Ca, Sr, Ba) phosphors was prepared by the combustion method, and the influence of these alkaline earth metals on the structure and luminescent performances for these phosphors was investigated. A relationship was established between their composition, ...

  18. Preparation of MAl 2 O 4 : Eu 2+ , Sm 3+ (M = Ca, Sr, Ba) Phosphors ...

    African Journals Online (AJOL)

    A series of MAl2O4: Eu2+, Sm3+ (M = Ca, Sr, Ba) phosphors was prepared by the combustion method, and the influence of these alkaline earth metals on the structure and luminescent performances for these phosphors was investigated. A relationship was established between their composition, crystallization capacity and ...

  19. Malária por Plasmodium falciparum: estudos proteômicos

    Directory of Open Access Journals (Sweden)

    Rodrigo Siqueira-Batista

    2012-12-01

    Full Text Available A despeito dos avanços no tratamento e das campanhas de prevenção e de controle da malária nos distintos continentes nos quais a moléstia grassa, a entidade mórbida permanece com significativa relevância no mundo contemporâneo. O Plasmodium falciparum é o grande responsável pela malária grave, caracterizada por distúrbios em diferentes órgãos e sistemas, com possibilidade de evolução ao óbito. Embora incipientes, os estudos proteômicos na malária têm trazido boas perspectivas para melhor compreensão dos aspectos biológicos do Plasmodium, assim como dos mecanismos fisiopatológicos, diagnósticos, terapêuticos e profiláticos da enfermidade. Desse modo, o objetivo do presente artigo é apresentar uma breve revisão das aplicações da análise proteômica na malária por P. falciparum.

  20. (VI) from water by micro-alloyed aluminium composite (MAlC)

    African Journals Online (AJOL)

    driniev

    2004-07-03

    Jul 3, 2004 ... Abstract. This paper deals with Cr(VI) ion removal from water, by micro-alloyed aluminium composite (MAlC), under flow conditions. In a water ... Cr(VI) were below the maximal allowed concentrations for drinking water, in all model solutions. ... mucous membrane irritant and some of these hexavalent com-.

  1. Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda

    DEFF Research Database (Denmark)

    Chimienti, Fabrice; Hogg, Ronald C; Plantard, Laure

    2003-01-01

    Mal de Meleda is an autosomal recessive inflammatory and keratotic palmoplantar skin disorder due to mutations in the ARS B gene, encoding for SLURP-1 (secreted mammalian Ly-6/uPAR-related protein 1). SLURP-1 belongs to the Ly-6/uPAR superfamily of receptor and secreted proteins, which participat...

  2. Early Revision Surgery for Tibial Plateau Non-union and Mal-union.

    Science.gov (United States)

    Van Nielen, Dominic L; Smith, Christopher S; Helfet, David L; Kloen, Peter

    2017-02-01

    Although relatively rare, non-unions and mal-unions of tibial plateau fractures present significant challenges for the orthopedic surgeon. With careful pre-operative planning, tibial plateau mal-union or non-union revision surgery with intra-articular and varus opening osteotomies can provides good functional results when performed early (within 1 year) after primary surgical procedure. We present our treatment algorithm for approaching and treating non-union or mal-union of tibial plateau fractures. Our aim is to give surgeons treating these difficult injuries an overview of the pertinent literature as well as describe the challenges and pitfalls we have experienced when treating non-union or mal-union of tibial plateau fractures. Using two case examples from our institution, one for mal-union and one for mal-reduction, we describe our treatment algorithm and surgical technique for managing these difficult injuries. We also provide a brief literature review outlining relevant studies and summarizing outcomes for similar injuries. A systematic literature review was conducted with the aim of determining the methods and outcomes commonly reported in the literature regarding revision surgery following tibial plateau non-union or mal-union. Due to the nature of revision surgery, there are no long-term randomized trials dealing with outcomes, but rather several smaller case series exist from which larger conclusions have to be drawn. To date, we have successfully treated approximately 35 patients with this technique, and clinical follow-up continues to show good functional outcomes with reduced pain and little radiographic evidence of arthritic changes. Restoring long leg alignment, anatomic reduction of the articular surface, and achieving stable internal fixation are paramount in achieving the best long-term outcome. Due to the shallow soft tissue envelope around the proximal tibia, and the tendency for these fractures to fall into progressive valgus collapse, these

  3. Structural and mutational analyses of Aes, an inhibitor of MalT in Escherichia coli.

    Science.gov (United States)

    Schiefner, André; Gerber, Kinga; Brosig, Alexander; Boos, Winfried

    2014-02-01

    The acyl esterase Aes effectively inhibits the transcriptional activity of MalT-the central activator of maltose and maltodextrin utilizing genes in Escherichia coli. To provide better insight into the nature of the interaction between Aes and MalT, we determined two different crystal structures of Aes-in its native form and covalently modified by a phenylmethylsulfonyl moiety at its active site serine. Both structures show distinct space groups and were refined to a resolution of 1.8 Å and 2.3 Å, respectively. The overall structure of Aes resembles a canonical α/β-hydrolase fold, which is extended by a funnel-like cap structure that forms the substrate-binding site. The catalytic triad of Aes, comprising residues Ser165, His292, and Asp262, is located at the bottom of this funnel. Analysis of the crystal-packing contacts of the two different space groups as well as analytical size-exclusion chromatography revealed a homodimeric arrangement of Aes. The Aes dimer adopts an antiparallel contact involving both the hydrolase core and the cap, with its twofold axis perpendicular to the largest dimension of Aes. To identify the surface area of Aes that is responsible for the interaction with MalT, we performed a structure-based alanine-scanning mutagenesis to pinpoint Aes residues that are significantly impaired in MalT inhibition, but still exhibit wild-type expression and enzymatic activity. These residues map to a shallow slightly concave surface patch of Aes at the opposite site of the dimerization interface and indicate the surface area that interacts with MalT. Copyright © 2013 Wiley Periodicals, Inc.

  4. High temperature increases the masculinization rate of the all-female (XX rainbow trout "Mal" population.

    Directory of Open Access Journals (Sweden)

    Karina Valdivia

    Full Text Available Salmonids are generally considered to have a robust genetic sex determination system with a simple male heterogamety (XX/XY. However, spontaneous masculinization of XX females has been found in a rainbow trout population of gynogenetic doubled haploid individuals. The analysis of this masculinization phenotype transmission supported the hypothesis of the involvement of a recessive mutation (termed mal. As temperature effect on sex differentiation has been reported in some salmonid species, in this study we investigated in detail the potential implication of temperature on masculinization in this XX mal-carrying population. Seven families issued from XX mal-carrying parents were exposed from the time of hatching to different rearing water temperatures ((8, 12 and 18°C, and the resulting sex-ratios were confirmed by histological analysis of both gonads. Our results demonstrate that masculinization rates are strongly increased (up to nearly two fold at the highest temperature treatment (18°C. Interestingly, we also found clear differences between temperatures on the masculinization of the left versus the right gonads with the right gonad consistently more often masculinized than the left one at lower temperatures (8 and 12°C. However, the masculinization rate is also strongly dependent on the genetic background of the XX mal-carrying families. Thus, masculinization in XX mal-carrying rainbow trout is potentially triggered by an interaction between the temperature treatment and a complex genetic background potentially involving some part of the genetic sex differentiation regulatory cascade along with some minor sex-influencing loci. These results indicate that despite its rather strict genetic sex determinism system, rainbow trout sex differentiation can be modulated by temperature, as described in many other fish species.

  5. Sector Information Data Set

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Fishing sectors were established in the Greater Atlantic region in 2010 under catch share management initiatives. Sector data kept at GARFO is mostly a collection of...

  6. [Eugen Helimski, Urlike Kahrs. Nordselkupisches Wörterbuch von F. G. Mal'cev (1903)] / Ago Künnap

    Index Scriptorium Estoniae

    Künnap, Ago, 1941-

    2003-01-01

    Raamatust: Helimski, Eugen, Kahrs, Urlike. Nordselkupisches Wörterbuch von F. G. Mal'cev (1903). Hamburg, 2001. (Hamburger Sibirische und Finnisch-Ugrische Materialen / Habent Sua Fata Manuscripts; 1)

  7. SmartMal: a service-oriented behavioral malware detection framework for mobile devices.

    Science.gov (United States)

    Wang, Chao; Wu, Zhizhong; Li, Xi; Zhou, Xuehai; Wang, Aili; Hung, Patrick C K

    2014-01-01

    This paper presents SmartMal--a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA) concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server's main task is to detect anomalies using state-of-art detection algorithms. Multiple distributed servers simultaneously analyze the feature vector using various detectors and information fusion is used to concatenate the results of detectors. We also propose a cycle-based statistical approach for mobile device anomaly detection. We accomplish this by analyzing the users' regular usage patterns. Empirical results suggest that the proposed framework and novel anomaly detection algorithm are highly effective in detecting malware on Android devices.

  8. Efekti malča u uzgoju šparoga Asparagu officinalis l.

    OpenAIRE

    Dudaš, Slavica

    2009-01-01

    U intenzivnoj povrtlarskoj proizvodnji je primjena malča sve češća. Pokrivanjem tla regulira se razvoj korova i utječe se pozitivno na fizičke i kemijske karakteristike tla. U ljetnom periodu vegetacije, višegodišnji nasadi šparoga zahtijevaju intenzivnu zaštitu od korova. U početnim stadijima razvoja izboja je moguća mehanička zaštita, u kasnijim stadijima uobičajena je primjena herbicida. Cilj istraživanja je ispitati efekte primjene različitih malč materijala u ljetnom periodu uzgoja šp...

  9. ANALISA PERBEDAAN MOTIVASI DAN PERSEPSI BERBELANJA DI MAL ANTARA ORANG TUA (IBU DAN PARA REMAJA PUTRINYA

    Directory of Open Access Journals (Sweden)

    Sasung Luckytawati

    2008-10-01

    The conceptual framework consists of the following constructs: consumption motivation social and con umption motivation objective as independent variables, and Mall Perception that consist ambience, design, layout, variety, excitement, involvement, desire to stay and desire to return as dependent variable. Moreover, five hypotheses were developed and tested. instrument test of validity and reliability used to test the measures, while independent t-test and multiple regressions were used in hypotheses testing. Data were collected from 100 dyadic pairs of mothers and daughters who had recently visited Mal at Jakarta. The resuIts indicate that mothers and daughters are motivated to consume by different factors, and tha they differ significantly in terms of their perceptions of critical mal environmental variables. Keywords: Consumption motivation social, Consumer behaviour, Mall Perception, and Design factors.

  10. SmartMal: A Service-Oriented Behavioral Malware Detection Framework for Mobile Devices

    OpenAIRE

    Chao Wang; Zhizhong Wu; Xi Li; Xuehai Zhou; Aili Wang; Hung, Patrick C. K.

    2014-01-01

    This paper presents SmartMal—a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA) concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server's main task is to detect anomalies using state-of-art detection...

  11. Apuntes sobre el mal y el endurecimiento del corazón

    Directory of Open Access Journals (Sweden)

    Adriana Menassé

    2015-06-01

    Full Text Available La decisión que lleva al ser humano a elegir entre el bien y el mal no parece tener explicación racional. Tal es al menos la postura de Kant, así como la de Levinas, quienes dejan la cuestión librada a su misterio último. La formulación que hace la Biblia en el libro del Éxodo, donde nunca es posible saber si Faraón endurece su corazón contra Dios o el propio Dios lo ha endurecido previamente, revela acaso esa misma, profunda ambivalencia. Marlowe y Shakespeare, por su lado, parecen inclinados a la idea de que el mal es una decisión de la voluntad y que su consumación es la ruina espiritual del ser humano. Siguiendo a nuestros clásicos quisiera suponer que el mal (al menos la transgresión y el crimen asumidos a conciencia es un gesto desesperado —si bien por ello no menos terrible: el alma que claudica en su anhelo de fincar en el sentido, de anudarse a la esperanza.

  12. Hybrid (laparoscopy + stent) treatment of celiac trunk compression syndrome (Dunbar syndrome, median arcuate ligament syndrome (MALS)).

    Science.gov (United States)

    Michalik, Maciej; Dowgiałło-Wnukiewicz, Natalia; Lech, Paweł; Majda, Kaja; Gutowski, Piotr

    2016-01-01

    Celiac trunk (CT) compression syndrome caused by the median arcuate ligament (MAL) is a rarely diagnosed disease because of its nonspecific symptoms, which cause a delay in the correct diagnosis. Intestinal ischemia occurs, which causes symptoms of abdominal angina. One method of treatment for this disease is surgical release of the CT - the intersection of the MAL. Laparoscopy is the first step of the hybrid technique combined with percutaneous angioplasty and stenting of the CT. To demonstrate the usefulness and advantages of the laparoscopic approach in the treatment of Dunbar syndrome. Between 2013 and 2016 in the General and Minimally Invasive Surgery Department of the Medical Sciences Faculty of the University of Warmia and Mazury in Olsztyn, 6 laparoscopic procedures were performed because of median arcuate ligament syndrome. During the laparoscopy the MAL was cut with a harmonic scalpel. One month after laparoscopy 5 patients had Doppler percutaneous angioplasty of the CT with stent implantation in the Vascular Surgery Department in Pomeranian Medical University in Szczecin. In one case, there was a conversion of laparoscopic surgery to open due to unmanageable intraoperative bleeding. In one case, postoperative ultrasound examination of the abdominal cavity demonstrated the presence of a large hematoma in the retroperitoneal space. All patients reported relief of symptoms in the first days after the operation. The hybrid method, combining laparoscopy and angioplasty, seems to be a long-term solution, which increases the comfort of the patient, brings the opportunity for normal functioning and minimizes the risk of restenosis.

  13. El Mal y la subjetivación política

    Directory of Open Access Journals (Sweden)

    Jairo H. Gómez-Esteban

    2014-01-01

    Full Text Available Doctor en Educación. Magíster en Sociología de la Educación. Psicólogo. Profesor Titular de la Universidad Distrital Francisco José de Caldas. Autor de diversos libros y artículos sobre pedagogía, educación política, jóvenes y problemas metodológicos de la investigación social. Miembro del grupo Vivencias. Autor de un libro de cuentos. Correo electrónico: El propósito de este ensayo es retomar el problema del Mal en los diversos modos de subjetivación política. Sus objetivos se sitúan en denunciar cómo las perspectivas afirmativas de la subjetividad escamotean el papel que el Mal cumple en los procesos de subjetivación, y señalar las implicaciones que tiene el Mal en la investigación de subjetividades políticas en un país con un conflicto armado inveterado que mantiene uno de los índices de desigualdad e injusticia social más alto, y cuyos investigadores e investigadoras asumen que la subjetivación política se encuentra únicamente en la participación y la democracia, en la autorregulación y la autonomía, en el reconocimiento y la identidad. @gmail.com

  14. MAL2 and tumor protein D52 (TPD52 are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

    Directory of Open Access Journals (Sweden)

    Fanayan Susan

    2010-09-01

    Full Text Available Abstract Background The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12. Independent expression microarray studies predict MAL2 overexpression in ovarian carcinoma, but these had remained unconfirmed. MAL2 binds tumor protein D52 (TPD52, which is frequently overexpressed in ovarian carcinoma, but the clinical significance of MAL2 and TPD52 overexpression was unknown. Methods Immunohistochemical analyses of MAL2 and TPD52 expression were performed using tissue microarray sections including benign, borderline and malignant epithelial ovarian tumours. Inmmunohistochemical staining intensity and distribution was assessed both visually and digitally. Results MAL2 and TPD52 were significantly overexpressed in high-grade serous carcinomas compared with serous borderline tumours. MAL2 expression was highest in serous carcinomas relative to other histological subtypes, whereas TPD52 expression was highest in clear cell carcinomas. MAL2 expression was not related to patient survival, however high-level TPD52 staining was significantly associated with improved overall survival in patients with stage III serous ovarian carcinoma (log-rank test, p Conclusions MAL2 is frequently overexpressed in ovarian carcinoma, and TPD52 overexpression is a favourable independent prognostic marker of potential value in the management of ovarian carcinoma patients.

  15. Sectoral Innovation Watch Biotechnology Sector. Final sector report

    NARCIS (Netherlands)

    Enzing, C.

    2011-01-01

    Biotechnology has evolved from a single set of technologies in the mid 1970s into a full grown technological field that is the driving force in innovation processes in many industrial sectors (pharmaceutical, medical, agriculture, food, chemical, environment, instruments). Nowadays, biotechnology is

  16. Sectoral Innovation Watch Food and Drinks Sector. Final Sector Report

    NARCIS (Netherlands)

    Leis, M.; Gijsbers, G.; Zee, F. van der

    2011-01-01

    The food and drinks manufacturing industry is a diverse and complex sector. There are ample possibilities for performance improvement and innovation in the food and drinks industry as well as a variety of challenges ranging from a lack of financial and human resources, fragmented consumer interests

  17. Second sector cool down

    CERN Multimedia

    2007-01-01

    At the beginning of July, cool-down is starting in the second LHC sector, sector 4-5. The cool down of sector 4-5 may occasionally generate mist at Point 4, like that produced last January (photo) during the cool-down of sector 7-8.Things are getting colder in the LHC. Sector 7-8 has been kept at 1.9 K for three weeks with excellent stability (see Bulletin No. 16-17 of 16 April 2007). The electrical tests in this sector have got opt to a successful start. At the beginning of July the cryogenic teams started to cool a second sector, sector 4-5. At Point 4 in Echenevex, where one of the LHC’s cryogenic plants is located, preparations for the first phase of the cool-down are underway. During this phase, the sector will first be cooled to 80 K (-193°C), the temperature of liquid nitrogen. As for the first sector, 1200 tonnes of liquid nitrogen will be used for the cool-down. In fact, the nitrogen circulates only at the surface in the ...

  18. The emerging fourth sector

    OpenAIRE

    Friis, Andreas

    2009-01-01

    The Fourth Sector is a new phenomenon related to dual social and financial value creation, until now not clearly defined with crisp sectoral boundaries and an operationalized definition. The phenomenon is getting increased attention in media, conferences, business schools and by organizations all over the world, and this study intends to explain the macroenvironmental changes that led to the rise of the fourth sector, describe new trends of social value creation in the private ...

  19. Communicating forest sector sustainability

    OpenAIRE

    Korhonen, E.; Toppinen, Anne; Lähtinen, K.; Ranacher, L.; Werner, Andrea; Stern, Tobias; Kutnar, Andreja

    2016-01-01

    Communication is an important tool in maintaining legitimacy and acceptability of forest sector operations and activities, and expectations by the general public on the forest sector conduct in Europe are in general very high. Despite this, there is scarce research in crossnational context on how forest sector sustainability is communicated to the general public, and what development areas can be identified in terms of communication content. This study applies a qualitative content analysis i...

  20. Mineral Processing Sector

    Science.gov (United States)

    Find environmental regulatory and compliance information for the nonmetallic mineral processing sector (NAICS 327), including NESHAPs for asbestos and hazardous waste, and wastewater permit information.

  1. Mal de Meleda: relato de 2 casos de ocorrência familiar Mal de Meleda: a report of two cases of familial occurrence

    Directory of Open Access Journals (Sweden)

    Fernanda Ayres de Morais e Silva

    2011-08-01

    Full Text Available Mal de Meleda é uma ceratodermia palmoplantar transgressiva rara, com prevalência estimada de 1:100.000 habitantes, descrita em 1826 por Stulli, na Ilha de Meleda. A herança autossômica recessiva foi descrita em 1938 e a alteração gênica no lócus 8qter, documentada em 1998. As principais manifestações clínicas decorrem da alteração da ceratinização palmoplantar. Há intensa hiperceratose transgressiva com eritema também no dorso das mãos e pés com distribuição em luvas e botas O aconselhamento genético faz-se necessário, sobretudo nos casos de consanguinidade. Nosso objetivo é relatar 2 casos de ocorrência familiar de pais consanguíneosMal de Meleda is a rare transgressive palmoplantar keratoderma with an estimated prevalence of 1 in 100,000 individuals. It was first described in 1826 by Stulli on the island of Mljet. Its autosomal recessive inheritance was described in 1938, and the defective gene was localized to chromosome 8qter in 1998. Clinical features are the result of abnormal palmoplantar keratinization and include severe symmetrical transgressive hyperkeratosis and erythema of the feet and hands in a glove-and-sock pattern. Genetic counseling is mandatory in cases of consanguinity. We report two cases of familial occurrence in the offspring of consanguineous parents

  2. Manifestações respiratórias na malária por Plasmodium falciparum e Vivax: vivax

    Directory of Open Access Journals (Sweden)

    C. Botelho

    1987-12-01

    Full Text Available Foram selecionados 110 pacientes que procuraram a SUCAM/CUIABÁ para diagnóstico e tratamento de malária, com queixa de febre e procedente de área malarígena. Nestes pacientes foram realizados: gota espessa para a pesquisa de Plasmodium; aplicação de questionário padronizado para detectar sintomas respiratórios presentes no momento da entrevista; gasometria arterial e espirometria para avaliar a função pulmonar. Desta amostra, 62 pacientes foram positivos para malária sendo 41 P. vivax, 20 P. falciparum e 01 forma mista (grupo Malárico; 48 mostraram-se negativos à pesquisa de hematozoários através da gota espessa (grupo Não Malárico. As manifestações respiratórias encontradas nesta população quando comparadas os grupos Malárico e Não Malárico, foram respectivamente: 1º Sintomáticos Respiratórios de 46,8% para 22 9% (p < 0,05; 2° Alterações Espirométricas de 53,2% para 20,8% (p < 0,05; 3° Alterações Gasométricas de 62,9% para 25,0% (p < 0,05. Com estes resultados concluímos que há nítida associação entre a Malária produzida pelo P. vivax e P. falciparum e as manifestações respiratórias apresentadas, nesta população de estudo.

  3. Pequeno mal epiléptico em crianças. Considerações sobre o efeito do tridione em 4 casos

    Directory of Open Access Journals (Sweden)

    Antonio B. Lefévre

    1949-03-01

    Full Text Available The author administered Tridione in four patients under five years of age with "petit mal" seizures. In all cases there was complete disappearance of the seizures eventhough small doses were used. In one case the EEG, taken after the Tridione treatment, did not show the previous "petit mal" pattern. In no case there were signs of intolerance. In conclusion the author thoroughly agree that Tridione is the drug of choice in "petit mal" seizures.

  4. DMPD: The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17449723 The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. Sh...Show The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. PubmedID 17449723 Title The Tro...ll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. Authors Sheedy F

  5. The Civil Society Sector

    OpenAIRE

    Anheier, Helmut K.; Lester M. Salamon

    2015-01-01

    Salamon and Anheier bring the civil society sector - the plethora of private, nonprofit, and nongovernmental organizations that have emerged in recent decades - into better focus conceptually as well as empirically. They draw on the results of a major inquiry into the scope, structure, financing and role of the "nonprofit sector" in a broad cross-section of countries around the world.

  6. Chemical and Petrochemical Sector

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    This publication is a background document on the global chemical and petrochemical sector for the IEA publication Energy Technology Transitions in Industry (IEA, 2009). It provides further, more detailed information on the methodology and data issues for energy efficiency indicators for the sector. The indicators discussed offer insight regarding the energy efficiency improvement potential in the short- to medium-term (by proven technologies).

  7. Adverse Impact of the Historic Mining Activities on the Enviroment in Malé Karpaty

    Directory of Open Access Journals (Sweden)

    Daniel Jozef

    2002-12-01

    Full Text Available During 1999 – 2001 the Ministry of the Environment of the Slovak Republic has financed the geological work „Evaluation of the Adverse Impact of Mining Activities on the Environment in the Region of Malé Karpaty“. Results and recommendations of the work in this contribution are discussed.Mineral resources, such as pyrit – pyrhotite deposits, hydrothermal metal ore deposits (Au – Ag, pyrit – Cu, Pb – Ag, Zn, Sb, hydrothermal deposits of barytes and manganesian ore deposits are situated in mining districts of Malé Karpaty. The exploitation of these deposits has been already finished. The deposits of limestone, building stones, earth and clay were or are quarried. The underground mined deposits were divided into 6 mining districts: Kuchyòa, Pernek, Pezinok, Modra, Èastá, and Borinka – Jabloòové. The impact of surface and underground mining on the environment was examined on 353 underground mining object and 117 quarries.The most important processes were studied: pollution of surface and groundwaters, soils and sediments, normal radioactivity of land, degradation of lands, ecological stability, disturbance of the ground, contemporary land-use influence, adverse effects on rocks, flora and fauna, and atmosphere. The mining waste disposals, underground mining works and mining objects, and quarries were investigated.According to the intensity of adverse impact on the environment, the mining objects in the region of Malé Karpaty were divided into 4 groups. Fifty seven mining objects and 87 quarries were recommended to the remedial treatment.The implementation of nature protection measures will eliminate or considerably reduce the damage done to the environment.Proposal of methodics for evaluation of the adverse impact of mining activities on the environment was elaborated as a part of the geological work.

  8. Hybrid (laparoscopy + stent treatment of celiac trunk compression syndrome (Dunbar syndrome, median arcuate ligament syndrome (MALS

    Directory of Open Access Journals (Sweden)

    Maciej Michalik

    2016-12-01

    Full Text Available Introduction : Celiac trunk (CT compression syndrome caused by the median arcuate ligament (MAL is a rarely diagnosed disease because of its nonspecific symptoms, which cause a delay in the correct diagnosis. Intestinal ischemia occurs, which causes symptoms of abdominal angina. One method of treatment for this disease is surgical release of the CT – the intersection of the MAL. Laparoscopy is the first step of the hybrid technique combined with percutaneous angioplasty and stenting of the CT. Aim: To demonstrate the usefulness and advantages of the laparoscopic approach in the treatment of Dunbar syndrome. Material and methods : Between 2013 and 2016 in the General and Minimally Invasive Surgery Department of the Medical Sciences Faculty of the University of Warmia and Mazury in Olsztyn, 6 laparoscopic procedures were performed because of median arcuate ligament syndrome. During the laparoscopy the MAL was cut with a harmonic scalpel. One month after laparoscopy 5 patients had Doppler percutaneous angioplasty of the CT with stent implantation in the Vascular Surgery Department in Pomeranian Medical University in Szczecin. Results : In one case, there was a conversion of laparoscopic surgery to open due to unmanageable intraoperative bleeding. In one case, postoperative ultrasound examination of the abdominal cavity demonstrated the presence of a large hematoma in the retroperitoneal space. All patients reported relief of symptoms in the first days after the operation. Conclusions : The hybrid method, combining laparoscopy and angioplasty, seems to be a long-term solution, which increases the comfort of the patient, brings the opportunity for normal functioning and minimizes the risk of restenosis.

  9. Sectoral Innovation Performance in the Electrical and Optical Equipment Sector

    NARCIS (Netherlands)

    Broek, T. van den; Giessen, A.M. van der

    2010-01-01

    The Electrical and Optical equipment sector is a high-tech manufacturing sector. It is one of the most innovative sectors in Europe with investments and advances in fundamental research, applied R&D and innovation in the actual use of equipment. This sector is also one of the most global sectors

  10. Exploring the Dark Sector

    Science.gov (United States)

    Essig, Rouven

    2014-03-01

    Dark sectors, consisting of new, light, weakly-coupled particles that do not interact with the known strong, weak, or electromagnetic forces, are a particularly compelling possibility for new physics. Nature may contain numerous dark sectors, each with their own beautiful structure, distinct particles, and forces. This talk summarizes the physics motivation for dark sectors and the exciting opportunities for experimental exploration. It discusses axions, axion-like particles, dark photons, and other dark-sector particles, including sub-GeV dark matter. In many cases, the exploration of dark sectors can proceed with existing facilities and comparatively modest experiments. A rich, diverse, and low-cost experimental program has the potential for one or more game-changing discoveries.

  11. Current methods for photodynamic therapy in the US: comparison of MAL/PDT and ALA/PDT.

    Science.gov (United States)

    Lee, Peter K; Kloser, Andrew

    2013-08-01

    There is some debate regarding the rate of progression of actinic keratosis (AK) into squamous cell carcinoma (SCC).1-4 However, it is clear that treatment for AK lesions is warranted. Results from numerous studies with aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) photodynamic therapy (PDT) for the treatment of AKs, SCC, and Bowen's disease show high rates of clearance for these lesions. MAL/PDT provides similar efficacy to ALA/PDT with the benefits of shorter incubation times according to the approved FDA labeling, greater selectivity, reduced pain during and immediately following therapy, and fewer systemic side effects. Cosmetic outcomes are better with PDT than with cryosurgery or excisional surgery. A number of case reports show efficacy with ALA/PDT and MAL/PDT for acne, photorejuvenation, and other off-label indications. Side effects with PDT tend to be mild to moderate and transient in nature. Overall, ALA/PDT and MAL/PDT are effective for a variety of skin diseases and conditions. MAL/PDT provides some advantages over ALA/PDT.

  12. Immune responses induced by recombinant BCG strains according to level of production of a foreign antigen: malE.

    Science.gov (United States)

    Himmelrich, H; Lo-Man, R; Winter, N; Guermonprez, P; Sedlik, C; Rojas, M; Monnaie, D; Gheorghiu, M; Lagranderie, M; Hofnung, M; Gicquel, B; Clément, J M; Leclerc, C

    2000-06-01

    A variety of viral, bacterial and parasitic antigens have been expressed in BCG and the capacity of these recombinant bacteria to induce immune responses has been well documented. However, little is known about the parameters influencing the induction of immune responses by recombinant BCG (rBCG), such as level of production and localization of the recombinant antigen. In the present study, we have constructed several rBCG strains expressing the malE gene from Escherichia coli which is either secreted or targeted to the cytoplasm or plasma membrane. Expression of malE was quantified by ELISA and localization was analyzed by flow cytometry. Even when using the same promoter, levels of cytoplasmic or membrane MalE production were far less than those from secreting strains using either mycobacterial or E. coli secretion signals. Stronger and more rapid immune responses were induced by rBCG strains with the highest levels of secreted MalE compared to cytoplasmic or membrane constructs, including both good humoral and proliferative responses in BALB/c, C57BL6 and even C3H mice, previously shown to be poor MalE responders. These results suggest that the levels of foreign antigen production play an important role in the induction of immune responses by rBCG strains.

  13. Surto de malária por Haemoproteus columbae em pombos

    OpenAIRE

    Resende,J.S.; Martins,N.R.S.; Jorge,M.A.

    2001-01-01

    Relata-se um surto de malária por Haemoproteus columbae em pombos-correio (Columba livia), caracterizado por um quadro agudo com mortalidade de 3% ao dia em aves de aspecto saudável ou crônico com prostração e fraqueza. O exame clínico das aves doentes evidenciou sinusite e conjuntivite e à necropsia traqueíte hemorrágica, aerossaculite, esplenomegalia, nefromegalia e hepatomegalia com hemorragias. O díptero hematófago da família Hippoboscidae Pseudolynchia canariensis foi encontrado inserido...

  14. Maternal grand mal seizure leads to a surprising diagnosis of Dandy-Walker variant.

    Science.gov (United States)

    Mendelson, Sherri G

    2011-01-01

    Pregnant women may present with abnormal symptoms that are assumed to be related to the pregnancy. The purpose of this case study is to examine an obstetric case that provides a wider view of a grand mal seizure in a perinatal patient with previously undiagnosed Dandy-Walker Variant. When a pregnant or newly postpartum woman has seizures, eclampsia may be the most the most likely diagnosis, but it may not be accurate. © 2011 AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses.

  15. Distinct mechanism of activation of two transcription factors, AmyR and MalR, involved in amylolytic enzyme production in Aspergillus oryzae.

    Science.gov (United States)

    Suzuki, Kuta; Tanaka, Mizuki; Konno, Yui; Ichikawa, Takanori; Ichinose, Sakurako; Hasegawa-Shiro, Sachiko; Shintani, Takahiro; Gomi, Katsuya

    2015-02-01

    The production of amylolytic enzymes in Aspergillus oryzae is induced in the presence of starch or maltose, and two Zn2Cys6-type transcription factors, AmyR and MalR, are involved in this regulation. AmyR directly regulates the expression of amylase genes, and MalR controls the expression of maltose-utilizing (MAL) cluster genes. Deletion of malR gene resulted in poor growth on starch medium and reduction in α-amylase production level. To elucidate the activation mechanisms of these two transcription factors in amylase production, the expression profiles of amylases and MAL cluster genes under carbon catabolite derepression condition and subcellular localization of these transcription factors fused with a green fluorescent protein (GFP) were examined. Glucose, maltose, and isomaltose induced the expression of amylase genes, and GFP-AmyR was translocated from the cytoplasm to nucleus after the addition of these sugars. Rapid induction of amylase gene expression and nuclear localization of GFP-AmyR by isomaltose suggested that this sugar was the strongest inducer for AmyR activation. In contrast, GFP-MalR was constitutively localized in the nucleus and the expression of MAL cluster genes was induced by maltose, but not by glucose or isomaltose. In the presence of maltose, the expression of amylase genes was preceded by MAL cluster gene expression. Furthermore, deletion of the malR gene resulted in a significant decrease in the α-amylase activity induced by maltose, but had apparently no effect on the expression of α-amylase genes in the presence of isomaltose. These results suggested that activation of AmyR and MalR is regulated in a different manner, and the preceding activation of MalR is essential for the utilization of maltose as an inducer for AmyR activation.

  16. Comparison of fin-and-tube interlaced and face split evaporators with flow mal-distribution and compensation

    DEFF Research Database (Denmark)

    Kærn, Martin Ryhl; Elmegaard, Brian; Larsen, L.F.S.

    2011-01-01

    Flow mal-distribution in fin-and tube evaporators for residential air-conditioning is investigated by numerical simulation. In particularly, the interlaced and the face split evaporator are compared in flow maldistribution conditions. The considered sources of mal-distribution are: Liquid....../vapor distribution and airflow distribution. Furthermore, compensation of flow mal-distribution by control of individual channel superheat is studied for each type of evaporator. It is shown that the interlaced evaporator is better at flow maldistribution than the face split evaporator. However, if individual...... channel superheats are controlled, the face split evaporator achieves the best performance, i.e. an increase of 7% in UA-value and 1.6% to 2.4% in COP compared to the interlaced evaporator without compensation....

  17. Exposure to Glycolytic Carbon Sources Reveals a Novel Layer of Regulation for the MalT Regulon

    Directory of Open Access Journals (Sweden)

    Sylvia A. Reimann

    2011-01-01

    Full Text Available Bacteria adapt to changing environments by means of tightly coordinated regulatory circuits. The use of synthetic lethality, a genetic phenomenon in which the combination of two nonlethal mutations causes cell death, facilitates identification and study of such circuitry. In this study, we show that the E. coli ompR malTcon double mutant exhibits a synthetic lethal phenotype that is environmentally conditional. MalTcon, the constitutively active form of the maltose system regulator MalT, causes elevated expression of the outer membrane porin LamB, which leads to death in the absence of the osmoregulator OmpR. However, the presence and metabolism of glycolytic carbon sources, such as sorbitol, promotes viability and unveils a novel layer of regulation within the complex circuitry that controls maltose transport and metabolism.

  18. O direito frente ao mal radical. A hipérbole kantiana do povo de demónios

    OpenAIRE

    Braz, Adelino

    2008-01-01

    A questão do mal radical em Kant não se limita à noção do indivíduo. Bem pelo contrário, as raízes do mal manifestam-se nas relações entre os seres humanos, justificando a necessidade e os limites do direito. Assim sendo, a hipérbole kantiana do povo de demónios mostra como a legislação jurídica neutraliza o mal a nível exterior sem ser capaz de erradicá-lo a nível interior. No entanto, trata-se aqui de constituir o direito unicamente como um meio de progresso, ou seja como uma condição de po...

  19. Cross-sector Innovation

    DEFF Research Database (Denmark)

    Würtz Jessen, Søren; Linnet, Andreas; Tscherning, Rasmus Wiinstedt

    2013-01-01

    The aim of this handbook is to help improve your opportunities for getting started on innovative and business development projects that reach beyond your own sector, commonly known as ’Cross-sector innovation’, or ’Cross innovation’ for short. We believe that there is a need for an easily read...... innovation handbook that can reach out to all sectors and potential partners whose point of departure, language use and understanding of customers is often very different to that of businesses. These differences constitute a resource for business development. If exploited they can lead to new ways of doing...

  20. Sector Economic Outlook. Energy

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-04-15

    The energy sector is a key driver of the economic pillar of Vision 2030. As the economy grows, urbanization intensifies and incomes increase, corporate and household demand for energy also rises. To meet this growth in demand for energy, the sector needs to increase investments and diversify into more sources of energy such as geothermal and wind power. It is therefore critical that focus is directed towards development and sustainability of the energy sector to ensure delivery of least cost power that will improve Kenya's competitiveness and achieve the Vision 2030 objective of 10% average annual economic growth.

  1. Aid and sectoral growth

    DEFF Research Database (Denmark)

    Selaya, Pablo; Thiele, Rainer

    2010-01-01

    This article examines empirically the proposition that aid to poor countries is detrimental for external competitiveness, giving rise to Dutch disease type effects. At the aggregate level, aid is found to have a positive effect on growth. A sectoral decomposition shows that the effect is (i......) significant and positive in the tradable and the nontradable sectors, and (ii) equally strong in both sectors. The article thus provides no empirical support for the hypothesis that aid reduces external competitiveness in developing countries. A possible reason for this finding is the existence of large idle...

  2. Formal sector subcontracting and informal sector employment in Indian manufacturing

    National Research Council Canada - National Science Library

    Moreno-Monroy, A.I; Pieters, J; Erumban, A.A

    2014-01-01

    Using nationally representative survey dta of Indian manufacturing enterprises spanning the period 1995-2006, we analyze the link between formal sector subcontracting and informal sector employment...

  3. A review of the prevalence and factors responsible for mal-nutrition in Pakistan

    Directory of Open Access Journals (Sweden)

    Hafsa Hina

    2015-01-01

    Full Text Available Problems occupying special attention identified by the World Health Organization also include Childhood malnutrition (Beagle hole et al., 1993. Development goals are also program by the United Nations to halve the problem of under nutrition (Alderman et al., 2005. Despite of the involvement of international organizations still under nutrition has a main contribution to the high mortality rate of the children in the most part of the world (Caulfield et al., 2004. Poverty plays a main part in the high prevalence of childhood under nutrition. The child is said to be under-weight when its weight is lower than the weight of the reference rage for that age. The weight for height deficiency is known as wasting, while height for age deficiency as stunting. Wasting may be due to acute food shortage while prolonged food deprivation can cause stunting (Cosminsky et al., 1993; de Onis et al., 2000; Fernandez et al., 2002; and Zere & McIntyre, 2003. The factors responsible for the predisposition of children to mal nutrition vary and ranges from political instability to the economical status of the area (de Onis et al., 2000. Therefore protocols developed for the preventive measures of mal-nutrition should be multifaceted. 

  4. Assessment of environmental enteropathy in the MAL-ED cohort study: theoretical and analytic framework.

    Science.gov (United States)

    Kosek, Margaret; Guerrant, Richard L; Kang, Gagandeep; Bhutta, Zulfiqar; Yori, Pablo Peñataro; Gratz, Jean; Gottlieb, Michael; Lang, Dennis; Lee, Gwenyth; Haque, Rashidul; Mason, Carl J; Ahmed, Tahmeed; Lima, Aldo; Petri, William A; Houpt, Eric; Olortegui, Maribel Paredes; Seidman, Jessica C; Mduma, Estomih; Samie, Amidou; Babji, Sudhir

    2014-11-01

    Individuals in the developing world live in conditions of intense exposure to enteric pathogens due to suboptimal water and sanitation. These environmental conditions lead to alterations in intestinal structure, function, and local and systemic immune activation that are collectively referred to as environmental enteropathy (EE). This condition, although poorly defined, is likely to be exacerbated by undernutrition as well as being responsible for permanent growth deficits acquired in early childhood, vaccine failure, and loss of human potential. This article addresses the underlying theoretical and analytical frameworks informing the methodology proposed by the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study to define and quantify the burden of disease caused by EE within a multisite cohort. Additionally, we will discuss efforts to improve, standardize, and harmonize laboratory practices within the MAL-ED Network. These efforts will address current limitations in the understanding of EE and its burden on children in the developing world. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  5. MalF is essential for persistence of Mycoplasma gallisepticum in vivo.

    Science.gov (United States)

    Tseng, Chi-Wen; Kanci, Anna; Citti, Christine; Rosengarten, Renate; Chiu, Chien-Ju; Chen, Zheng-Hong; Geary, Steven J; Browning, Glenn F; Markham, Philip F

    2013-07-01

    There is limited understanding of the molecular basis of virulence in the important avian pathogen Mycoplasma gallisepticum. To define genes that may be involved in colonization of chickens, a collection of mutants of the virulent Ap3AS strain of M. gallisepticum were generated by signature-tagged transposon mutagenesis. The collection included mutants with single insertions in the genes encoding the adhesin GapA and the cytadherence-related protein CrmA, and Western blotting confirmed that these mutants did not express these proteins. In two separate in vivo screenings, two GapA-deficient mutants (ST mutants 02-1 and 06-1) were occasionally recovered from birds, suggesting that GapA expression may not always be essential for persistence of strain Ap3AS. CrmA-deficient ST mutant 33-1 colonized birds poorly and had reduced virulence, indicating that CrmA was a significant virulence factor, but was not absolutely essential for colonization. ST mutant 04-1 contained a single transposon insertion in malF, a predicted ABC sugar transport permease, and could not be reisolated even when inoculated by itself into a group of birds, suggesting that expression of MalF was essential for persistence of M. galliseptium strain Ap3AS in infected birds.

  6. Modeling environmental influences on child growth in the MAL-ED cohort study: opportunities and challenges.

    Science.gov (United States)

    Richard, Stephanie A; McCormick, Benjamin J J; Miller, Mark A; Caulfield, Laura E; Checkley, William

    2014-11-01

    Although genetics, maternal undernutrition and low birth weight status certainly play a role in child growth, dietary insufficiency and infectious diseases are key risk factors for linear growth faltering during early childhood. A primary goal of the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) study is to identify specific risk factors associated with growth faltering during the first 2 years of life; however, growth in early childhood is challenging to characterize because growth may be inherently nonlinear with age. In this manuscript, we describe some methods for analyzing longitudinal growth to evaluate both short- and long-term associations between risk factors and growth trajectories over the first 2 years of life across 8 resource-limited settings using harmonized protocols. We expect there will be enough variability within and between sites in the prevalence of risk factors and burden of linear growth faltering to allow us to distinguish some of the key pathways to linear growth faltering in the MAL-ED study. Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.

  7. Daylight PDT with MAL - current data and practical recommendations of an expert panel.

    Science.gov (United States)

    Philipp-Dormston, Wolfgang G; Karrer, Sigrid; Petering, Holger; Ulrich, Claas; Dirschka, Thomas; Berking, Carola; Lonsdorf, Anke S; Gerber, Peter Arne; Radakovic, Sonja; Hunger, Robert E; Szeimies, Rolf-Markus

    2015-12-01

    Photodynamic Therapy (PDT) is one of the standard treatment modalities for actinic keratoses (AKs). Daylight PDT (DL-PDT) with MAL cream is a rather recent development, which, instead of an artificial light source, uses daylight for the activation of the photosensitizer. The present review summarizes available data based on a selective literature search, highlights practical aspects, and reflects the authors' expert knowledge in using DL-PDT. With respect to efficacy, study data shows that DL-PDT is noninferior to conventional PDT (cPDT). However, given that DL-PDT is markedly less painful, it is significantly better tolerated than cPDT. In Europe, DL-PDT can be performed from March to October, on sunny as well as on cloudy days. UV protection of untreated areas of the body should be observed. Outside temperature should not fall below 10°C. On hot days, patients should be advised to stay in the shade if necessary. Representing a useful addition to current therapeutic options, DL-PDT with MAL cream is, among others, suitable for patients with field cancerization and/or those who have experienced severe pain associated with cPDT. © 2015 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

  8. La Simbólica del Mal de Paul Ricoeur comentada

    Directory of Open Access Journals (Sweden)

    Marie-France Begué

    2015-04-01

    Full Text Available El presente trabajo recoge la exposición brindada por Marie-France Begué al SIPLET (Seminario Interdisciplinario Permanente Litera-tura, Estética y Teología en torno a la Simbólica del mal de Paul Ricoeur. En él, se presenta la concepción de símbolo para Ricoeur, con sus dimensiones cósmica, onírica y poética, y la descripción fenomenológica que el autor hace del mal a partir de los símbolos de la mancha, el pecado y la culpa. El objetivo principal del texto fue brindar una introducción al pensamiento de Ricoeur en dicha obra a los participantes del seminario, en función del trabajo que ellos vienen realizando en torno al diálogo entre poesía y mística.

  9. Olhar de dirigentes sindicais sobre qualidade de vida no trabalho e mal-estar no trabalho

    Directory of Open Access Journals (Sweden)

    Remigio Todeschini

    2013-06-01

    Full Text Available O objeto do artigo consistiu em conhecer as percepções de dirigentes sindicais metalúrgicos e químicos sobre o tema Qualidade de Vida no Trabalho (QVT e as fontes de mal-estar no trabalho nessas categorias profissionais. A natureza metodológica aplicada foi quantitativa e qualitativa com utilização do software Alceste. Participaram da pesquisa 81 dirigentes sindicais brasileiros (56 dirigentes químicos e 25 metalúrgicos, 85% do gênero masculino e 15% do gênero feminino oriundos das regiões sudeste, sul e nordeste do país, com aplicação do questionário via e-mail. Os resultados encontrados forneceram bases empíricas para a formulação de recomendações em Ergonomia da Atividade visando prevenir as fontes de mal-estar no trabalho. Foram reforçadas as bases teóricas da Abordagem de Ergonomia da Atividade Aplicada à Qualidade de Vida no Trabalho (EAA_QVT e o desenho de subsídios para a formulação de políticas públicas neste campo.

  10. Fronteiras da urbanidade sanitária: sobre o controle da malária Frontiers of sanitary urbanity: on malária control

    Directory of Open Access Journals (Sweden)

    István van Deursen Varga

    2007-04-01

    Full Text Available Propomos aqui uma discussão sobre a população rural como objeto de políticas e práticas no campo da Saúde Pública. Interessa-nos identificar quando, de que modo e em que contextos econômicos, políticos e ideológicos ela foi ou vem sendo contemplada com serviços e/ou ações específicas de saúde por parte de instituições públicas. Para isso, enfocamos as políticas de combate à malária, reconhecida, ainda em nossos dias, como a endemia de maior impacto sobre a população rural da Amazônia. Trata-se, portanto, de uma discussão sobre a trajetória das políticas de controle de endemias no Brasil (no contexto da trajetória das políticas de saúde, em especial sobre as instituições responsáveis por sua execução, ilustrada com dados empíricos e trechos de entrevistas que colhemos em trabalhos de campo no Maranhão o estado com a maior porcentagem de população rural do Brasil. Concluímos com um estudo de caso sobre dados e tendências atuais da malária no estado, e com alguns comentários sobre os atuais desafios para seu controle.We propose here a discussion about rural population as the object of policies and practices in the Public Health field. We are interested in identifying if, when, in what ways, and in what economic, political and ideological contexts it received or has been receiving, from public institutions, specific health services and/or actions. To achieve this, we focus on the policies that combat malaria, still recognized, nowadays, as the endemic of widest impact on the rural population of the Amazon region. This is, therefore, a discussion about the trajectory of the endemics control policies in Brazil (in the context of the health policies' trajectory, especially about the institutions responsible for their execution, illustrated by empirical data and extracts from interviews we collected in fieldworks in Maranhão the state with the highest percentage of rural population in Brazil. We conclude with

  11. Sectoral Innovation Watch electrical and Optical Equipment Sector. Final sector report

    NARCIS (Netherlands)

    Broek, T. van den; Giessen, A.M. van der

    2011-01-01

    The electrical and optical equipment sector is a high-tech manufacturing sector. It is one of the most innovative sectors in Europe with investments and advances in fundamental research, applied R&D and innovation in the actual use of equipment. This sector is also one of the most global sectors

  12. El sector productivo The productive sector

    Directory of Open Access Journals (Sweden)

    Encarna Santolaria

    2004-05-01

    Full Text Available El crecimiento del sector servicios en detrimento del sector primario, la flexibilidad del mercado laboral y la progresiva incorporación de la mujer a dicho mercado son los cambios más destacados del sector productivo español en los últimos 25 años. Las mujeres en España presentan tasas de desempleo, trabajo temporal y a tiempo parcial mucho mayores que los hombres. Además, las condiciones de acceso al mercado de trabajo y las condiciones en las que éste se desempeña están también muy relacionadas con la clase social. Las mujeres cubren la escasez de servicios públicos destinados al cuidado de las criaturas pequeñas y de las personas mayores o dependientes, y realizan una labor de cuidadoras informales sin reconocimiento social, lo cual les impide el acceso a un puesto de trabajo o su mantenimiento y limita de forma decisiva las posibilidades de desarrollo y progreso profesional. Todo ello indica una clara diferencia con respecto a los hombres en cuanto a la frecuencia de contratos temporales y de tiempo parcial, así como en la segregación laboral, tanto horizontal como vertical. Estos aspectos de segregación son más evidentes en las mujeres de clases sociales menos privilegiadas, en las que se concentran las peores condiciones de acceso al mercado laboral y de trabajo. En España es imprescindible llevar a cabo políticas que ofrezcan servicios que permitan compatibilizar la vida laboral y familiar en condiciones de mayor equidad, tanto en razón de género como de clase social.In the last 25 years, the production sector in Spain has undergone important changes. Among these changes, the important growth of the services sector at the expense of the primary sector, the increasing flexibility of the labour market, and the rise in the female workforce could be considered as the most relevant ones. Spanish women have higher rates of unemployment, temporary jobs and part time contracts than Spanish men. Moreover, job access and work

  13. Deletion mutation in Drosophila ma-l homologous, putative molybdopterin cofactor sulfurase gene is associated with bovine xanthinuria type II.

    Science.gov (United States)

    Watanabe, T; Ihara, N; Itoh, T; Fujita, T; Sugimoto, Y

    2000-07-21

    Defective xanthine dehydrogenase (XDH) activity in humans results in xanthinuria and xanthine calculus accumulation in kidneys. Bovine xanthinuria was demonstrated in a local herd and characterized as xanthinuria type II, similar to the Drosophila ma-l mutations, which lose activities of molybdoenzymes, XDH, and aldehyde oxidase, although sulfite oxidase activity is preserved. Linkage analysis located the disease locus at the centromeric region of bovine chromosome 24, where a ma-l homologous, putative molybdopterin cofactor sulfurase gene (MCSU) has been physically mapped. We found that a deletion mutation at tyrosine 257 in MCSU is tightly associated with bovine xanthinuria type II.

  14. Public Sector Expatriate Managers:

    DEFF Research Database (Denmark)

    Fenner, Charles, R., Jr.; Selmer, Jan

    2008-01-01

    Although public sector expatriates are becoming increasingly common, research on them is very limited. There is reason to believe that the situation for expatriates from the public sector may be different than for those from the private sector. This study investigated U.S. Department of Defense...... administrators assigned to U.S. embassies worldwide. Results showed that self efficacy, role clarity and role discretion had a positive association with the psychological adjustment of the respondents while role conflict and role overload only had a marginal negative relationship with the criterion variable....... On the other hand, neither international experience nor the effectiveness of preparatory training had any association with the psychological adjustment of respondents. Surprisingly, these findings suggest a similar picture for the expatriates from the public and private sector. Implications of these findings...

  15. Tanzania - Water Sector Project

    Data.gov (United States)

    Millennium Challenge Corporation — Social Impact (SI) has been contracted by MCC to carry out an impact evaluation (IE) of the Tanzania Water Sector Project. This IE examines the effect of the WSP...

  16. Buildings Sector Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Hostick, Donna J.; Nicholls, Andrew K.; McDonald, Sean C.; Hollomon, Jonathan B.

    2005-08-01

    A joint NREL, ORNL, and PNNL team conducted market analysis to help inform DOE/EERE's Weatherization and Intergovernmental Program planning and management decisions. This chapter presents the results of the market analysis for the Buildings sector.

  17. Construction Sector (NAICS 23)

    Science.gov (United States)

    Find environmental regulatory information for the construction sector, including the construction of buildings or engineering projects. This includes RCRA information for hazardous waste, refrigeration compliance, asbestos, effluent guidelines & lead laws

  18. Public sector wages

    OpenAIRE

    B. Eugène

    2011-01-01

    Remuneration paid by public administrations in Belgium amounted to one-quarter of their primary expenditure in 2010. Because current conditions call for fiscal consolidation, it is important to examine whether this component of spending could be a source of budget savings, including by adjusting wages. The article focuses principally on wage gaps between the public sector and the private sector. The authors are especially interested in the situation in Belgium as compared with those of nine o...

  19. Public Sector Organizations

    DEFF Research Database (Denmark)

    Meyer, Renate; Leixnering, Stephan

    2015-01-01

    New public management-inspired reforms created numerous autonomous units with many different faces and labels. This variety of organizations and organizational forms precludes a straightforward definition of what constitutes a public sector organization and blurs the boundaries between the public...... and private sectors as well as the boundaries of single organizations. In addition, the complexity of the interlocking arrangements and relationships in this public organizational landscape has resulted in considerable governance problems with serious implications for coordination and policy coherence....

  20. Contribution of Agricultural Sector and Sub Sectors on Indonesian Economy

    Directory of Open Access Journals (Sweden)

    Refa’ul Khairiyakh

    2016-04-01

    Full Text Available This research aimed to analyze trend of agricultural GDP and agricultural contribution in Indonesia, and identify the role of agricultural sector and sub sectors in provinces of Indonesia. Source of data this research use linear trend analysis to analyze trend agricultural Gross Domestic Product (GDP and agricultural contribution. Location Quotient (LQ, Dynamic Location Quotient (DLQ, and combination LQ and DLQ is used to identify the role of agricultural sector and sub sectors. The analysis found that agricultural GDP in Indonesia has increasing trend while agricultural contribution has decreasing trend. Agricultural sector is basic sector in 29 provinces in Indonesia. Farm food crop is leading sub sector in 6 provinces, farm non food crops is leading sub sector in 14 provinces, livestock is leading sub sector in 3 provinces, forestry is leading sub sector in 1 provinces, fishery is leading sub sector in 5 provinces.

  1. Saman ve pomza malçı ile jips uygulamalarının alkali bir toprağın ıslahındaki etkileri

    OpenAIRE

    TEMİZ, Çağla

    2016-01-01

    Bu çalışmanın amacı, saman ve pomza malç materyallerinin farklı düzeylerde jipsle birlikte uygulanmaları halinde, alkali toprak ıslahındaki etkinliğini belirlemektir. Araştırma tesadüf parselleri deneme desenine göre 3 tekerrürlü olarak 27 adet kolonda yürütülmüştür. PVC kolonlara aşağıdaki deneme planına göre hazırlanan jips ve malç materyali ilave edilmiştir. Çalışma; 1. % 100 Jips gereksinimi, malçsız, 2. % 75 Jips gereksinimi, malçsız, 3. % 50 Jips gereksinimi, malçsız, 4. % 100 ...

  2. La Justificación de la Presencia del Mal en el Mundo desde la Estética Agustiniana

    Directory of Open Access Journals (Sweden)

    David Ezequiel Téllez Maqueo

    2016-07-01

    Full Text Available La posibilidad de establecer una conciliación entre Dios como principio absoluto de bondad, y el mal presente en la realidad en sus más diversas manifestaciones (miseria, guerras, enfermedad, ignorancia, etc., ha sido una preocupación constante en la historia del pensamiento occidental. Si Dios existe, ¿cómo puede suceder que exista mal en el mundo? Para dar una respuesta racional satisfactoria se han planteado diversas respuestas. Pero Agustin de Hipona representa la primera teodicea dominante de la historia occidental, por lo que el conocimiento de su postura ante este problema es digno de interés. Para ello, el objetivo de estas líneas es triple: 1 establecer en qué consiste la solución estética de san Agustin al problema del mal, II señalar algunas de las críticas más conocidas que ha recibido en el siglo XX, y III afirmar que la solución agustiniana puede seguir siendo base de una teodicea capaz de hacer compatible la existencia de Dios y el mal en el mundo, tras la valoración de las distintas posturas críticas que ha recibido.

  3. Mal de Pott: Uma Doença Milenar em um Novo Século

    Directory of Open Access Journals (Sweden)

    Frederico Soares Falcetta

    2009-09-01

    Full Text Available A tuberculose espinhal, também conhecida como Mal de Pott ou Doença de Pott, caracteriza-se como a forma mais frequente de tuberculose extrapulmonar. Apresentamos aqui o caso de uma paciente encaminhada ao Serviço de Neurologia do Hospital de Clínicas de Porto Alegre com um quadro de dois meses de evolução, apresentando sintomas de compressão medular. O diagnóstico de tuberculose espinhal foi realizado por punção guiada por tomografia computadorizada e a paciente foi submetida à drenagem do abscesso. Concomitantemente, foi iniciado o tratamento com RHZ e a paciente evoluiu com melhora dos sintomas neurológicos. Esse caso ilustra que mesmo pacientes com alterações neurológicas importantes devido à tuberculose medular podem apresentar melhora significativa com tratamento

  4. Data extraction for complex meta-analysis (DECiMAL) guide.

    Science.gov (United States)

    Pedder, Hugo; Sarri, Grammati; Keeney, Edna; Nunes, Vanessa; Dias, Sofia

    2016-12-13

    As more complex meta-analytical techniques such as network and multivariate meta-analyses become increasingly common, further pressures are placed on reviewers to extract data in a systematic and consistent manner. Failing to do this appropriately wastes time, resources and jeopardises accuracy. This guide (data extraction for complex meta-analysis (DECiMAL)) suggests a number of points to consider when collecting data, primarily aimed at systematic reviewers preparing data for meta-analysis. Network meta-analysis (NMA), multiple outcomes analysis and analysis combining different types of data are considered in a manner that can be useful across a range of data collection programmes. The guide has been shown to be both easy to learn and useful in a small pilot study.

  5. SmartMal: A Service-Oriented Behavioral Malware Detection Framework for Mobile Devices

    Directory of Open Access Journals (Sweden)

    Chao Wang

    2014-01-01

    Full Text Available This paper presents SmartMal—a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server’s main task is to detect anomalies using state-of-art detection algorithms. Multiple distributed servers simultaneously analyze the feature vector using various detectors and information fusion is used to concatenate the results of detectors. We also propose a cycle-based statistical approach for mobile device anomaly detection. We accomplish this by analyzing the users’ regular usage patterns. Empirical results suggest that the proposed framework and novel anomaly detection algorithm are highly effective in detecting malware on Android devices.

  6. DIREITO DE EXCEÇÃO: OS RISCOS DE UM MAL NECESSÁRIO

    Directory of Open Access Journals (Sweden)

    Mariana Belchior Ribeiro Freire

    2010-08-01

    Full Text Available O presente trabalho tem como escopo analisar o estado de exceção no seu liame entre a manutenção do status quo ante e o salto para a revolução. Sob a óptica dos pensamentos de renomados filósofos (Jean Bodin, Thomas Hobbes, Rosseau, Hans Kelsen e Carl Schmitt, procuramos analisar os benefícios e os riscos da instituição do estado de exceção, tendo em vista que se pode considerar este um mal necessário. O estado de exceção é um avanço nas democracias contemporâneas, como observaremos a sua previsão importa uma segurança à sociedade de que é possível mudar preservando alguns direitos constitucionais.

  7. SmartMal: A Service-Oriented Behavioral Malware Detection Framework for Mobile Devices

    Science.gov (United States)

    Wu, Zhizhong; Li, Xi; Zhou, Xuehai; Wang, Aili; Hung, Patrick C. K.

    2014-01-01

    This paper presents SmartMal—a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA) concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server's main task is to detect anomalies using state-of-art detection algorithms. Multiple distributed servers simultaneously analyze the feature vector using various detectors and information fusion is used to concatenate the results of detectors. We also propose a cycle-based statistical approach for mobile device anomaly detection. We accomplish this by analyzing the users' regular usage patterns. Empirical results suggest that the proposed framework and novel anomaly detection algorithm are highly effective in detecting malware on Android devices. PMID:25165729

  8. Violência e alteridade: o mal-estar na adolescência

    Directory of Open Access Journals (Sweden)

    Marta Rezende Cardoso

    Full Text Available Explorar a articulação entre violência pulsional e adolescência é um dos objetivos principais deste trabalho no qual se procura sublinhar os aspectos traumáticos envolvidos nessa passagem. Destaca-se a questão da revivência do Édipo e, particularmente, a sua ressonância, muitas vezes também traumática, no psiquismo dos próprios pais. Um belíssimo e trágico romance de Arthur Schnitzler (1913 – Madame Béate e seu filho – relato de múltiplas passagens ao ato, apoiadas simultaneamente nos vividos inconscientes de uma mãe e seu filho adolescente diante de um intraduzível “mal-estar”, inspira e auxilia a elaboração das idéias apresentadas.

  9. Mal de Debarquement Syndrome: A Rare Entity—A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Veronica Nwagwu

    2015-01-01

    Full Text Available Mal de Debarquement Syndrome (MDS is a rare, understudied, underdiagnosed, and self-limiting condition. Etiology and incidence are unknown. It is characterized by abnormal sensation of motion/balance reported after travel by air, land, and sea; being reexposed to motion/activity relieves it. Symptoms may last from minutes to years. Workup though required reveals no findings; it is a diagnosis of exclusion. While no efficacious treatment exists, amitriptyline and benzodiazepines as well as supportive therapy have proved to be useful. We have described a 40-year-old Caucasian female who presented for the evaluation of persistent rocking and swaying sensation after a ship cruise which lasted for one week. Patient was treated with benzodiazepines after extensive workup and is now stable. A high index of suspicion is required to make a diagnosis.

  10. malERA: An updated research agenda for malaria elimination and eradication.

    Science.gov (United States)

    Rabinovich, Regina N; Drakeley, Chris; Djimde, Abdoulaye A; Hall, B Fenton; Hay, Simon I; Hemingway, Janet; Kaslow, David C; Noor, Abdisalan; Okumu, Fredros; Steketee, Richard; Tanner, Marcel; Wells, Timothy N C; Whittaker, Maxine A; Winzeler, Elizabeth A; Wirth, Dyann F; Whitfield, Kate; Alonso, Pedro L

    2017-11-01

    Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming health, equity, and economic benefits. WHO and countries are setting ambitious goals for reducing the burden and eliminating malaria through the "Global Technical Strategy" and 21 countries are aiming to eliminate malaria by 2020. The commitment to achieve these targets should be celebrated. However, the need for innovation to achieve these goals, sustain elimination, and free the world of malaria is greater than ever. Over 180 experts across multiple disciplines are engaged in the Malaria Eradication Research Agenda (malERA) Refresh process to address problems that need to be solved. The result is a research and development agenda to accelerate malaria elimination and, in the longer term, transform the malaria community's ability to eradicate it globally.

  11. Bhaktapur, Nepal: the MAL-ED birth cohort study in Nepal.

    Science.gov (United States)

    Shrestha, Prakash Sunder; Shrestha, Sanjaya Kumar; Bodhidatta, Ladaporn; Strand, Tor; Shrestha, Binob; Shrestha, Rita; Chandyo, Ram Krishna; Ulak, Manjeswori; Mason, Carl J

    2014-11-01

    The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study site in Nepal is located in the Bhaktapur municipality, 15 km east of Kathmandu, the capital city of Nepal. Bhaktapur, an ancient city famous for its traditional temples and buildings, is included on UNESCO's World Heritage List and is a major tourist attraction in Nepal. Nepal is a land-locked country located in South Asia between China and India with an area of 147 181 km(2), ranging from sea-level plains to Mount Everest, the world's highest peak. The total population as of the 2011 census was 26.6 million, with an average annual population growth rate of 1.4. Nepal is one of the world's least developed countries and is ranked 157 of 186 in the 2013 Human Development Report; one-third of the Nepali population lives below the poverty line. The current under-5 mortality rate is 54 per 1000 live births, the infant mortality rate is 46 per 1000 live births, and the neonatal mortality rate is 33 per 1000 live births. Vaccine coverage for all Expanded Program on Immunization vaccines is >80%. Among children, the most common diseases contributing to significant morbidity and mortality are acute respiratory infection and dehydration from severe diarrhea. In this article, we report on the geographic, demographic, and socioeconomic features of the Bhaktapur MAL-ED site and describe the data that informed our cohort recruitment strategy. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  12. ACCUMULATION OF POLYHYDROXYALKANOIC ACIDS BY AZOTOBACTER CHROOCOCCUM MAL-201 FROM ORGANIC WASTE

    Directory of Open Access Journals (Sweden)

    Soma Pal Saha

    2013-08-01

    Full Text Available Azotobacter chroococcum MAL-201 (MTCC 3853, a free-living nitrogen-fixing bacterium accumulated intracellular poly(3-hydroxybutyric acid [P(3HB] accounting 69% of cell dry weight (CDW when grown in nitrogrn-free Stockdale medium containing 2% (w/v glucose. It also produced copolymer of poly(3-hydroxybutyrate co-3-hydroxyvalerate [P(3HB-co-3HV] using glucose as primary carbon source and valerate cas cosubstrate. To make the polymer production cost effective four types of waste material of different origin were tested for growth and polymer production. Stockdale medium supplemented with 1% (w/v waste materials failed to yield good growth and polymer accumulation. Two–step cultivation was adopted for better growth and enhanced polymer accumulation. The candy factory waste was most suitable for synthesis of P(3HB accounting 17.8 and 40.58% using single and two-step cultivation conditions respectively. Wastes of domestic and poultry origin produced P(3HB-co-3HV with 3HV content 28.8 and 21.5 mol% respectively in two-step cultivation. Increase concentration of these wastes resulted in further upliftment of 3HV content of polymer with reduced growth and polymer accumulation. However, at optimum incubation the strain MAL-201 cells accumulated P(3HB 48.5% of CDW (at 40h from candy factory waste and P(3HB-co-3HV 24.75 % of CDW with 3HV 34.65 mol % from domestic waste. Intrinsic viscosity, molecular weight and thermal degradation of the polymers accumulated in the cells grown in glucose, glucose with valerate and glucose with waste were compared.

  13. Lethality of MalE-LacZ hybrid protein shares mechanistic attributes with oxidative component of antibiotic lethality.

    Science.gov (United States)

    Takahashi, Noriko; Gruber, Charley C; Yang, Jason H; Liu, Xiaobo; Braff, Dana; Yashaswini, Chittampalli N; Bhubhanil, Sakkarin; Furuta, Yoshikazu; Andreescu, Silvana; Collins, James J; Walker, Graham C

    2017-08-09

    Downstream metabolic events can contribute to the lethality of drugs or agents that interact with a primary cellular target. In bacteria, the production of reactive oxygen species (ROS) has been associated with the lethal effects of a variety of stresses including bactericidal antibiotics, but the relative contribution of this oxidative component to cell death depends on a variety of factors. Experimental evidence has suggested that unresolvable DNA problems caused by incorporation of oxidized nucleotides into nascent DNA followed by incomplete base excision repair contribute to the ROS-dependent component of antibiotic lethality. Expression of the chimeric periplasmic-cytoplasmic MalE-LacZ72-47 protein is an historically important lethal stress originally identified during seminal genetic experiments that defined the SecY-dependent protein translocation system. Multiple, independent lines of evidence presented here indicate that the predominant mechanism for MalE-LacZ lethality shares attributes with the ROS-dependent component of antibiotic lethality. MalE-LacZ lethality requires molecular oxygen, and its expression induces ROS production. The increased susceptibility of mutants sensitive to oxidative stress to MalE-LacZ lethality indicates that ROS contribute causally to cell death rather than simply being produced by dying cells. Observations that support the proposed mechanism of cell death include MalE-LacZ expression being bacteriostatic rather than bactericidal in cells that overexpress MutT, a nucleotide sanitizer that hydrolyzes 8-oxo-dGTP to the monophosphate, or that lack MutM and MutY, DNA glycosylases that process base pairs involving 8-oxo-dGTP. Our studies suggest stress-induced physiological changes that favor this mode of ROS-dependent death.

  14. MAL Overexpression Leads to Disturbed Expression of Genes That Influence Cytoskeletal Organization and Differentiation of Schwann Cells

    Directory of Open Access Journals (Sweden)

    Daniela Schmid

    2014-09-01

    Full Text Available In the developing peripheral nervous system, a coordinated reciprocal signaling between Schwann cells and axons is crucial for accurate myelination. The myelin and lymphocyte protein MAL is a component of lipid rafts that is important for targeting proteins and lipids to distinct domains. MAL overexpression impedes peripheral myelinogenesis, which is evident by a delayed onset of myelination and reduced expression of the myelin protein zero (Mpz/P0 and the low-affinity neurotrophin receptor p75NTR . This study shows that MAL overexpression leads to a significant reduction of Mpz and p75NTR expression in primary mouse Schwann cell cultures, which was already evident before differentiation, implicating an effect of MAL in early Schwann cell development. Their transcription was robustly reduced, despite normal expression of essential transcription factors and receptors. Further, the cAMP response element-binding protein (CREB and phosphoinositide 3-kinase signaling pathways important for Schwann cell differentiation were correctly induced, highlighting that other so far unknown rate limiting factors do exist. We identified novel genes expressed by Schwann cells in a MAL-dependent manner in vivo and in vitro. A number of those, including S100a4, RhoU and Krt23, are implicated in cytoskeletal organization and plasma membrane dynamics. We showed that S100a4 is predominantly expressed by nonmyelinating Schwann cells, whereas RhoU was localized within myelin membranes, and Krt23 was detected in nonmyelinating as well as in myelinating Schwann cells. Their differential expression during early peripheral nerve development further underlines their possible role in influencing Schwann cell differentiation and myelination.

  15. Sectoral Market Mechanisms

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    This paper first reviews proposals for the design of sectoral and related market mechanisms currently debated, both in the UNFCCC negotiations, and in different domestic legislative contexts. Secondly, it addresses the possible principles and technical requirements that Parties may wish to consider as the foundations for further elaboration of the mechanisms. The third issue explored herein is domestic implementation of sectoral market mechanisms by host countries, incentives to move to new market mechanisms, as well as how the transition between current and future mechanisms could be managed.

  16. El mal de ojo y su relación con el marasmo y kwashiorkor: El caso de las madres de Turbo, Antioquia, Colombia Mal de ojo and its relationship with marasm and kwashiorkor: the Turbo mother’s case

    Directory of Open Access Journals (Sweden)

    Gildardo Uribe Gil

    2007-03-01

    Full Text Available Objetivo: Describir las percepciones y prácticas socio-culturales de las madres frente al proceso de desnutrición aguda grave de los niños: marasmo y kwashiorkor. Metodología: Etnografía descriptiva. Se realizaron 20 entrevistas semiestructuradas, 2 entrevistas grupales y observación en los hogares y en el hospital. El análisis se realizó manualmente. Resultados: Las madres perciben la desnutrición aguda grave como una consecuencia del mal de ojo, el cual afecta a los niños menores de 7 años. El mal de ojo se clasifica como "ojo secador" y "ojo de la calle". Para las madres, el ojo secador enmagrece totalmente a los niños, lo cual podríamos asimilar al marasmo. No es claro si el ojo de la calle conlleva al kwashiorkor, pero es claro que el kwashirkor es causado por el mal de ojo. Los médicos tradicionales, como los rezanderos, ocupan un lugar importante en el tratamiento de las enfermedades de filiación cultural. Conclusiones: En el modelo biomédico no existen ni el mal de ojo ni la desnutrición como enfermedad. La desnutrición se conceptúa como estado y finalmente se objetiviza en cifras estadísticas, lo cual dificulta la atención integral de los niños. El estudio devela un mundo desconocido por el sistema biomédico, y un mundo de prácticas culturales frente al proceso de desnutrición, que adecuadamente valoradas permitirían mejorar la atención integral y evitar la muerte infantil por desnutrición aguda grave o por el mal de ojo.Objective: To describe perceptions and socio- cultural practices by the mothers facing severe malnutrition in children: Marasm and Kwashiorkor. Methodology: Descriptive ethnography. Twenty semi-structured interviews and two tribal ones were carried. Homes and hospitalized children were observed. Analysis was manually performed. Results: Mother perceives severe malnutrition like "mal de ojo" consequence afflicting children under seven. Mal de ojo is classified as "drying-eye" or as "street

  17. Public sector innovation

    DEFF Research Database (Denmark)

    Wegener, Charlotte

    2012-01-01

    This paper explores the value dimension of public innovation in the light of practitioners’ values and asks why there seems to be a clash between innovation imperatives and workplace practices in the public sector. The paper contributes to the research on public innovation from a practice...

  18. Financial Sector Assessment

    OpenAIRE

    World Bank; International Monetary Fund

    2017-01-01

    A joint International Monetary Fund (IMF)-World Bank mission visited Rabat and Casablanca in 2015, to assess the soundness and resilience of the banking system, the state of play in financial inclusion and infrastructure, the oversight frameworks for banking, capital markets and financial market infrastructures, crisis preparedness, and update the findings of the Financial Sector Assessme...

  19. Financial Sector Assessment : Morocco

    OpenAIRE

    World Bank

    2003-01-01

    This Financial Sector Assessment (FSA) provides a summary of the policy priorities, and main findings intended to assist the Moroccan authorities in evaluating the country's financial system. It reviews the uneasy trade-off between concerns for stability, and development, suggesting Morocco's macroeconomic policies and practices as a whole tend to err more on the side of the concerns of pr...

  20. Public Sector Performance

    NARCIS (Netherlands)

    B. Kuhry

    2004-01-01

    The performance of the public sector of national economies is a crucial factor in the race to achieve the goals in the Lisbon Agenda. It is therefore useful to relate differences in performance in education, health care, law and order, and public administration to differences in resource use and

  1. nigeria's banking sector reforms

    African Journals Online (AJOL)

    NESG PUBLICATIONS

    the Banks and Other Financial. Institutions Act of (BOFIA)1 1991 as amended, the CBN anchored the banking sector reform on a 13-point agenda involving (CBN, 2005: 16). Minimum bank capital base of N25 billion that must be met on or before 31st December, 2005: ♢. Consolidation through mergers and acquisition,.

  2. Revolución y muerte. La banalidad del mal en los cuentos “Preludio” y “Cenizas para el viento”

    OpenAIRE

    Álvarez Vásquez, Lina Maryory

    2016-01-01

    Este artículo presenta un análisis de los cuentos de Hernando Téllez “Cenizas para el viento” y “Preludio”, a partir de la definición de la banalidad del mal expuesta por Hannah Arendt en el año 1963 -- Luego se realiza un estudio de los personajes de los cuentos a partir de las dimensiones individuales de la banalidad del mal y finalmente se presenta otros personajes en los que la banalidad del mal no logra instaurase

  3. Searching for Dark Sectors

    Science.gov (United States)

    Zhong, Yi-Ming

    The existence of Dark Matter suggests the presence of a dark sector, consisting of particles neutral under all Standard Model forces. Various "portals" can connect the dark sector to the Standard Model sector. Two popular examples are the vector portal, which gives rise to a "dark photon" ( A'), and the Higgs portal, which gives rise to a "dark Higgs". Such dark forces appear in many well-motivated extensions of the Standard Model. In some cases, they may resolve discrepancies between experimental data and theoretical predictions, such as the muon anomalous magnetic moment. We show that dark sectors and forces can be constrained from several novel probes in current and future experiments, including mono- photon searches in low-energy positron-electron colliders, rare muon decays in the Mu3e, and exotic Higgs decays at the Large Hadron Collider (LHC). We first investigate the power of low-energy, high-luminosity electron-positron colliders to probe dark sectors with a mass below 10 GeV, which couple to Standard Model particles through a low-mass dark mediator. Dark matter candidates in this mass range are well- motivated and can give rise to distinctive mono-photon signals at B-factories and similar experiments. We use data from an existing mono-photon search by BABAR to place new constraints on this class of models, and give projections for the sensitivity of a similar search at a future B-factory such as Belle II. We find that the sensitivity of such searches are more powerful than searches at other collider or fixed-target facilities for dark-sector mediators and particles with masses between a few hundred MeV and 10 GeV. We compare our results to existing and future direct detection experiments and show that low-energy colliders provide an indispensable and complementary avenue to search for light dark matter. We also find that dark photons with masses 10 MeV - 80 MeV can probed in the rare muon decay process mu+→ e+nue numuA', A '→ e+ e-, in the upcoming Mu

  4. Malária grave importada: relato de caso Severe imported malaria: case report

    Directory of Open Access Journals (Sweden)

    Alessandra Alves

    2007-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A malária ainda representa um problema de saúde global. A forma grave da doença é causada principalmente por P. falciparum e pode cursar com complicações cerebrais, renais, pulmonares, hematológicas, circulatórias e hepáticas. O objetivo deste estudo foi relatar um caso de paciente portador de malária grave importada. RELATO DO CASO: Paciente do sexo masculino, 30 anos, pardo, filipino, marinheiro, proveniente de embarcação vinda da Nigéria, com história de dor abdominal no hipocôndrio direito, icterícia, febre e rebaixamento do nível de consciência. Os exames laboratoriais de admissão mostraram hiperbilirrubinemia de 50 mg/dL, acidose metabólica grave, trombocitopenia, creatinina de 5,6 mg/dL, leucocitose com desvio até metamielócitos. O escore APACHE II foi de 37, com risco de óbito de 88%. Durante a internação foi diagnosticada malária por P. falciparum pelo teste de gota espessa. Mesmo com tratamento antimalárico adequado, o paciente evoluiu com insuficiência renal aguda necessitando de hemodiálise e síndrome de angústia respiratória aguda (SARA, necessitando de ventilação mecânica (VM, choque refratário tratado com aminas vasoativas, além de quadro hematológico, configurando um caso grave de disfunção de múltiplos de órgãos. Ainda apresentou pneumonia associada à VM e sepse relacionada ao uso de cateteres. Após a alta hospitalar, o paciente não apresentou seqüelas cerebral, pulmonar ou renal. CONCLUSÕES: Dos critérios definidores de malária grave descritos na literatura, o paciente preenchia: insuficiência renal aguda, síndrome da angústia respiratória aguda (SARA, acidose metabólica, alteração do nível de consciência, hemoglobinúria macroscópica, hiperparasitemia e hiperbilirrubinemia, que se relaciona a uma mortalidade maior que 10%, na dependência do tratamento precoce e dos recursos disponíveis. A malária grave exige diagnóstico e tratamento

  5. Le problème du mal dans le Guide des Perplexes et son arrière-plan talmudique

    Directory of Open Access Journals (Sweden)

    Costa, José

    2010-12-01

    Full Text Available At first sight, the question of evil is regarded in the Guide for the Perplexed in a paradoxical manner. Thus, in Guide I, 2, Maimonides examines the notions of good and evil as subjective evaluations possessing neither the rigour not the exactness of the notions of true and false. However, the question of evil occupies an essential place in the Guide, as various modern authors have shown. This question is important to Maimonides because he is, in this respect, the heir of the rabbinic tradition and his conception of evil is largely based on an interaction with the Talmudic and Midrašic texts. Therefore, we would like to review thirty-nine rabbinic ‘quotes’ which appear in chapters 8 to 24 in the third part of the Guide and deal with the origin of evil, the meaning of suffering and the evil inclination. Maimonides reappropriates the midrašim that are susceptible of being in agreement with his rationalist positions and also quotes some rabbinic traditions that are too close to mu ͑tazilism, undoubtedly aware of the more profound resemblance that exists between the rabbinic and mu ͑tazilite doctrines of evil and retribution.A primera vista, el problema del mal es abordado en la Guía de Perplejos de manera paradójica. Para Maimónides, las nociones de bien y mal son subjetivas y no resultan ni rigorosas ni exactas, a la inversa de las nociones de verdad y falsedad (Guía I, 2. Sin embargo, el problema del mal es muy importante en la Guía, como lo demostraran varios autores. Maimónides es el heredero de la tradición rabínica y existe en la Guía una interacción entre la filosofia de Maimónides y los textos talmúdicos y midrásicos. Es particularmente el caso de las treinta y nueve citas rabínicas de la Guía II, 8-24, que tratan del origen del mal, del significado del sufrimiento y de la inclinación al mal. Maimónides cita los midrašim que concuerdan con sus posiciones racionalistas y evoca también algunas tradiciones rab

  6. Epilepsia"Petit Mal" aspectos clínicos, eletrencefalográficos e evolutivos

    Directory of Open Access Journals (Sweden)

    Paulo Pinto Pupo

    1961-01-01

    Full Text Available In the past few years somewhat new yet often differing points of view have been affirmed refering to Petit Mal epilepsy, with regard to its clinical, eletrencephalographic and evolutive aspects. The classical concept of PM epilepsy as established by Lennox and Gibbs, with its well defined clinical and EEGraphic characteristics is continually being modified with new research work on clinical and EEGraphic aspects. Numerous clinical cases have been published whose evolution clashes with that classically described and likewise numerous are those cases where the EEG shows signs of focal electric activity besides spike and wave dis-rythmia. Cases have been known where surgical exerese on the focus causes temporary desappearance of the spike and wave disrythmia. The present concept now holding sway is that PM epilepsy is a kind of reaction of infantile encephalon to diverse harmful causes. From this it will be seen we are very far from the concept that PM epilepsy is a pure form of idiopathic epilepsy. For these reasons we decided to re-examine those cases observed between 1950 and 1960. With this in mind we chose 141 PM epilepsy cases, from among over 23000 epileptics, all examined under a standard criterion by a small group of senior assistants. All cases suspected of Psm epilepsy were excluded. The analysis of this group of patients was compared to that of another group with GM as well as PM seizures (104 patients; in 52 of these cases, studies were made concerning the evolutive, clinical and EEGra-phic aspects. METHOD: Clinical criterion was used for selection of the cases. The results of the analysis from the clinical and EEGraphic point of view were exhibited in demonstrative graphs. From the clinical point of view we strove to find out positive hereditary elements, organic cerebral injury factor (intellectual deficit, mood and behaviour disturbances, neurologic or somatic signs, as well as other development anomalies, the presence of febrile

  7. Functional expression and molecular characterization of Culex quinquefasciatus salivary α-glucosidase (MalI).

    Science.gov (United States)

    Suthangkornkul, Rungarun; Sirichaiyakul, Phanthila; Sungvornyothin, Sungsit; Thepouyporn, Apanchanid; Svasti, Jisnuson; Arthan, Dumrongkiet

    2015-06-01

    Salivary α-glucosidases (MalI) have been much less characterized when compared with midgut α-glucosidases, which have been studied in depth. Few studies have been reported on the partial characterization of MalI, but no clear function has been ascribed. The aim of this study is to purify and characterize the recombinant Culex quinquefasciatus (CQ) α-glucosidase expressed in Pichia pastoris. The cDNA encoding mature Cx. quinquefasciatus α-glucosidase gene with polyhistidine tag (rCQMalIHis) was successfully cloned into the expression vector, pPICZαB, designated as pPICZαB/CQMalIHis. The activity of recombinant rCQMalIHis expressed in P. pastoris could be detected at 3.75U/ml, under optimal culture conditions. The purified rCQMalIHis showed a single band of molecular weight of approximately 92kDa on SDS-PAGE. After Endoglycosidase H digestion, a single band at 69kDa was found on SDS-PAGE analysis, suggesting that rCQMalIHis is a glycoprotein. Additionally, tryptic digestion and LC-MALDI MS/MS analysis suggested that the 69kDa band corresponds to the Cx. quinquefasciatus α-glucosidase. Thus, rCQMalIHis is a glycoprotein. The rCQMalIHis exhibited optimum pH and temperature at 5.5 and 35°C, respectively. The catalytic efficiency (kcat/Km) of the purified rCQMalIHis for maltotriose is higher than those for sucrose, maltotetraose, maltose and p-nitrophenyl-α-glucoside, indicating that the enzyme prefers maltotriose. Additionally, the rCQMalIHis is significantly inhibited by d-gluconic acid δ-lactone, but not by Mg(2+), Ca(2+) and EDTA. The rCQMalIHis is strongly inhibited by acarbose with IC50 67.8±5.6nM, but weakly inhibited by glucose with IC50 115.9±7.3mM. Copyright © 2015 Elsevier Inc. All rights reserved.

  8. Composite Dark Sectors

    Energy Technology Data Exchange (ETDEWEB)

    Carmona, Adrián [Institute for Theoretical Physics, ETH Zurich,Wolfgang-Pauli-Str. 27, 8093 Zurich (Switzerland); Chala, Mikael [DESY,Notkestraße 85, 22607 Hamburg (Germany)

    2015-06-16

    We introduce a new paradigm in Composite Dark Sectors, where the full Standard Model (including the Higgs boson) is extended with a strongly-interacting composite sector with global symmetry group G spontaneously broken to H⊂G. We show that, under well-motivated conditions, the lightest neutral pseudo Nambu-Goldstone bosons are natural dark matter candidates for they are protected by a parity symmetry not even broken in the electroweak phase. These models are characterized by only two free parameters, namely the typical coupling g{sub D} and the scale f{sub D} of the composite sector, and are therefore very predictive. We consider in detail two minimal scenarios, SU(3)/[SU(2)×U(1)] and [SU(2){sup 2}×U(1)]/[SU(2)×U(1)], which provide a dynamical realization of the Inert Doublet and Triplet models, respectively. We show that the radiatively-induced potential can be computed in a five-dimensional description with modified boundary conditions with respect to Composite Higgs models. Finally, the dark matter candidates are shown to be compatible, in a large region of the parameter space, with current bounds from dark matter searches as well as electroweak and collider constraints on new resonances.

  9. Composite Dark Sectors

    Energy Technology Data Exchange (ETDEWEB)

    Carmona, Adrian [ETH Zuerich (Switzerland). Inst. for Theoretical Physics; Chala, Mikael [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2015-06-15

    We introduce a new paradigm in Composite Dark Sectors, where the full Standard Model (including the Higgs boson) is extended with a strongly-interacting composite sector with global symmetry group G spontaneously broken to H is contained in G. We show that, under well-motivated conditions, the lightest neutral pseudo Nambu-Goldstone bosons are natural dark matter candidates for they are protected by a parity symmetry not even broken in the electroweak phase. These models are characterized by only two free parameters, namely the typical coupling g{sub D} and the scale f{sub D} of the composite sector, and are therefore very predictive. We consider in detail two minimal scenarios, SU(3)/[SU(2) x U(1)] and [SU(2){sup 2} x U(1)]/[SU(2) x U(1)], which provide a dynamical realization of the Inert Doublet and Triplet models, respectively. We show that the radiatively-induced potential can be computed in a five-dimensional description with modified boundary conditions with respect to Composite Higgs models. Finally, the dark matter candidates are shown to be compatible, in a large region of the parameter space, with current bounds from dark matter searches as well as electroweak and collider constraints on new resonances.

  10. First successful reduction of clinical allergenicity of food by genetic modification: Mal d 1-silenced apples cause fewer allergy symptoms than the wild-type cultivar

    DEFF Research Database (Denmark)

    Dubois, A. E. J.; Pagliarani, G.; Brouwer, R. M.

    2015-01-01

    BACKGROUND: Genetic modification of allergenic foods such as apple has the potential to reduce their clinical allergenicity, but this has never been studied by oral challenges in allergic individuals. METHODS: We performed oral food challenges in 21 apple-allergic individuals with Elstar apples...... which had undergone gene silencing of the major allergen of apple, Mal d 1, by RNA interference. Downregulation of Mal d 1 gene expression in the apples was verified by qRT-PCR. Clinical responses to the genetically modified apples were compared to those seen with the wild-type Elstar using a visual...... analogue scale (VAS). RESULTS: Gene silencing produced two genetically modified apple lines expressing Mal d 1.02 and other Mal d 1 gene mRNA levels which were extensively downregulated, that is only 0.1-16.4% (e-DR1) and 0.2-9.9% (e-DR2) of those of the wild-type Elstar, respectively. Challenges...

  11. EMOCIONES MORALES Y POLÍTICAS EN EL PARADIGMA DEL MAL: EL (NO LUGAR DE LA INFANCIA

    Directory of Open Access Journals (Sweden)

    MARIETA QUINTERO MEJÍA

    2016-08-01

    Full Text Available En el campo de la filosofía, algunos teóricos han mostrado la importancia que tienen las emociones en la promoción de acciones orientadas al bien común. En oposición a estos presupuestos, encontramos el paradigma del mal, del cual se derivan reflexiones teóricas acerca del lugar de las emociones como activadoras de la crueldad. Se destaca el valor otorgado a la infancia en el aprendizaje de las emociones, pero también la afectación de hechos atroces en su sensibilidad (su no lugar Este artículo busca hacer una revisión de diferentes tesis comprensivas acerca de las emociones, su cultivo desde la infancia y su efecto en contextos atroces (paradigma del mal.

  12. Challenges and Developments in the Assessment of (Mal)adaptive Personality and Pathological States in Older Adults.

    Science.gov (United States)

    Rossi, Gina; Videler, Arjan; van Alphen, S P J

    2017-01-01

    Since older adults often show an atypical presentation of (mal)adaptive personality traits and pathological states, the articles in this special issue will concisely discuss some perennial issues in clinical assessment in older adults and thus outline the main challenges this domain faces. By bringing empirical work and meta-analytic studies from leading scholars in the field of geropsychology, the articles will also address these challenges by reporting the latest developments in the field. This way, we hope to reshape the way clinicians and researchers assess (mal)adaptive personality and pathological states in older adults into a more reliable and valid assessment method that integrates the specific biopsychosocial context of older age.

  13. Perceptions of the Third Sector

    NARCIS (Netherlands)

    Bekkers, R.H.F.P.; Brink Lund, A.

    2014-01-01

    How do citizens in Europe view third sector organizations? How can differences in perceptions of the third sector among citizens in Europe be explained? And how is the third sector assessed therein with regard to its contribution to social innovation? Based on the limited scope of the evidence

  14. Higgs Portal into Hidden Sectors

    CERN Multimedia

    CERN. Geneva

    2007-01-01

    Several attractive theoretical ideas suggest the existence of one or more 'hidden sectors' consisting of standard model singlet fields, some of which may not be too heavy. There is a profound reason to think that the Higgs sector might provide the first access to these hidden sectors. This scenario could affect Higgs phenomenology in drastic ways.

  15. GOVERNMENT ASSISTANCE FOR INFORMAL SECTOR ...

    African Journals Online (AJOL)

    UDS-CAPTURED

    operators of informal sector activities in three urban areas of Fiji that the major obstacle to informal sector business in Fiji is lack of finance (60%). Other constraints include lack of know- how and skills, and discriminatory government regulation. The most important expectation or requirement of informal sector operators in Fiji ...

  16. Malária por Plasmodium falciparum: estudos proteômicos Plasmodium falciparum malaria: proteomic studies

    Directory of Open Access Journals (Sweden)

    Rodrigo Siqueira-Batista

    2012-12-01

    Full Text Available A despeito dos avanços no tratamento e das campanhas de prevenção e de controle da malária nos distintos continentes nos quais a moléstia grassa, a entidade mórbida permanece com significativa relevância no mundo contemporâneo. O Plasmodium falciparum é o grande responsável pela malária grave, caracterizada por distúrbios em diferentes órgãos e sistemas, com possibilidade de evolução ao óbito. Embora incipientes, os estudos proteômicos na malária têm trazido boas perspectivas para melhor compreensão dos aspectos biológicos do Plasmodium, assim como dos mecanismos fisiopatológicos, diagnósticos, terapêuticos e profiláticos da enfermidade. Desse modo, o objetivo do presente artigo é apresentar uma breve revisão das aplicações da análise proteômica na malária por P. falciparum.Despite advances in treatment and campaigns for prevention and control of malaria on the various continents where it is still rampant, this disease remains significantly relevant to the contemporary world. Plasmodium falciparum is the organism that is mainly responsible for severe malaria, which is characterized by disturbances in different organs and systems, with possibly fatal outcomes. Although incipient, proteomic studies of malaria have yielded favorable prospects for elucidating the biological aspects of Plasmodium as well as the pathophysiological, diagnostic, prophylactic, and therapeutic mechanisms of the disease. Thus, the aim of the present article is to present a brief review of the applications of proteomic analysis in P. falciparum malaria.

  17. Estudo clínico da malária falciparum em crianças em Manaus, AM, Brasil

    Directory of Open Access Journals (Sweden)

    Noronha Elza

    2000-01-01

    Full Text Available As características clínicas da malária falciparum foram estudadas em 61 crianças com idade de 0 a 14 anos, atendidas em centro de referência em Manaus, entre outubro e dezembro de 1997. Os sintomas encontrados foram febre (98,4%, cefaléia (80,3%, calafrios (68,9%, sudorese (65,6%, mialgia (59%, náuseas (54,1%, lombalgia (49,2%, vômitos (49,2%, tosse (45,9%, artralgia (31,1%, diarréia (34,4%, dispnéia (8,2%, convulsões (8,2% e tonturas (4,9%. Palidez cutâneo-mucosa e anemia foram observadas mais freqüentemente nas crianças menores de 5 anos. A anemia esteve asssociada aos maiores níveis de parasitemia. Cinqüenta e oito (91,5% pacientes apresentaram malária não complicada, 3 (4,9% malária grave e a letalidade foi 1,6%.

  18. Recombinant Mal d 1 facilitates sublingual challenge tests of birch pollen-allergic patients with apple allergy.

    Science.gov (United States)

    Kinaciyan, T; Nagl, B; Faustmann, S; Kopp, S; Wolkersdorfer, M; Bohle, B

    2016-02-01

    It is still unclear whether allergen-specific immunotherapy (AIT) with birch pollen improves birch pollen-related food allergy. One reason for this may be the lack of standardized tests to assess clinical reactions to birch pollen-related foods, for example apple. We tested the applicability of recombinant (r) Mal d 1, the Bet v 1-homolog in apple, for oral challenge tests. Increasing concentrations of rMal d 1 in 0.9% NaCl were sublingually administered to 72 birch pollen-allergic patients with apple allergy. The dose of 1.6 μg induced oral allergy syndromes in 26.4%, 3.2 μg in 15.3%, 6.3 μg in 27.8%, 12.5 μg in 8.3%, 25 μg in 11.1%, and 50 μg in 4.2% of the patients. No severe reactions occurred. None of the patients reacted to 0.9% NaCl alone. Sublingual administration of 50 μg of rMal d 1 induced no reactions in three nonallergic individuals. Our approach allows straight forward, dose-defined sublingual challenge tests in a high number of birch pollen-allergic patients that inter alia can be applied to evaluate the therapeutic efficacy of birch pollen AIT on birch pollen-related food allergy. © 2015 The Authors. Allergy Published by John Wiley & Sons Ltd.

  19. La naturaleza del mal en el pensamiento de Hannah Arendt | The nature of evil in Hannah Arendt’s thinking

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    María Cristina Hermida del Llano

    2016-12-01

    Full Text Available RESUMEN. La cuestión del mal ocupa un lugar central en el pensamiento de Hannah Arendt al constituir un concepto transversal que recorre todos sus trenes de pensamiento. Se somete a análisis la “naturaleza del mal” a través del estudio de su obra y de su propia experiencia vital, especialmente al cubrir el juicio de Eichmann en Jerusalén, donde ella afirmaría que éste representaba “la banalidad del mal”. Se trata de averiguar si en su particular concepción del mal influyó Voltaire, por qué surge el mal, por qué se manifiesta de forma permanente en la historia y si puede ser destruido   ABSTRACT. The topic of evil has a central place in Hannah Arendt’s thinking as it lies at the core of all her trains of thought. We analyze the “nature of evil” in Hannah Arendt’s philosophy through the study of her work and of her life experience, especially when she covered the trial of Eichmann in Jerusalem where she pointed out that Eichmann represented “the banality of evil”. Our goal in this contribution is to understand whether the philosophy of Voltaire could have influenced Arendt’s conception of evil, why it arises, why it persists throughout history, and whether it can be destroyed

  20. Měnič pro malý 3f asynchronní motor

    OpenAIRE

    Pavlík, Ondřej

    2013-01-01

    Cílem této diplomové práce je pokračovat v prototypní realizaci a finálním návrhu třífázového frekvenčního měniče zkušebně navrženého v rámci bakalářské práce. Měnič je koncipován pro malý asynchronní motor do výkonu 100 W a je určen pro napájení motoru ventilátoru. Návrh byl optimalizován z hlediska nízké ceny a technické proveditelnosti. Silová část měniče je řešena pomocí obvodu FSB50450, který je napájen z kompaktního zdroje MYRRA47155. Řízení měniče zajišťuje obvod MC3PHAC. Zařízení je m...

  1. The essential oil of Thymus aureopunctatus (Beck) K. Malý.

    Science.gov (United States)

    Cavara, Sanja; Maksimović, Milka; Vidic, Danijela

    2009-03-01

    Essential oil of Thymus aureopunctatus (Beck) K. Malý, obtained by hydrodistillation and headspace technique, was subjected to capillary GC-MS analysis, and its volatile composition was compared with essential oil profile of Thymus serpyllum L. and a botanically undetermined thyme species, Thymus spp., all growing wild in the same habitat in Bosnia and Herzegovina. This paper presents the first report on phytochemical analysis of the rare T. aureopunctatus species, and also the first report on headspace analysis of plants belonging to the genus Thymus. One hundred and two volatile constituents were identified. The investigated Thymus species of Bosnian origin clearly belong to the thymol-chemotype with relatively abundant level of this main constituent varying from 30.5% for T. serpyllum, and 34.5% for T. aureopunctatus, to 44.2% for Thymus spp., while their corresponding headspace samples contain very high percentage of p-cymene, thymol biosynthesis precursor, in the range from 29.1% to 68.1%.

  2. Decodificando la esencia del mal, o del terror a la muerte del hijo

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    Maximiliano Korstanje

    2011-01-01

    Full Text Available Durante muchos años filósofos y teólogos se han cuestionado sobre la cuestión de la caída. Es innumerable la bibliografía sobre el tema como así también las propias dudas sobre la omnipresencia y sabiduría de un Dios que implícitamente o no permite la presencia del pecado por medio de su propia creación. El mito fundador de querubín Lucifer no sólo simboliza la relación entre el hombre y la traición sino también el amor filial entre el padre y su creación las cuales concilian la negación cultural de la muerte de la progenie o generaciones más jóvenes. Utilizando la teoría antropológica de los dones de M. Mauss, el presente trabajo teórico intentará explicar el origen mítico del mal dentro de la tradición judeo-cristiana como una de las elaboraciones más temidas, la muerte del hijo.

  3. Quema de libros y antitotalitarismo. Manuel Rivas Los libros arden mal y Ray Bradbury Fahrenheit 451

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    Mechthild Albert

    2016-07-01

    Full Text Available The current article aims at a comparison of Manuel Rivas’ Los libros arden mal (2006 and Ray Bradbury’s Fahrenheit 451 (1953. Both novels share the anti-totalitarian commitment which is, in both cases, exemplified by the book burning motive, considered the climax of anti-cultural barbarism. Based on Fernando Rodríguez de la Flor’s reflections on biblioclasm (2004, parallels can be found in the following aspects: the zoo- and anthropomorphic description of the burning books; biblioclasm as an expression of totalitarianism, indicating, furthermore, an ambivalent and dialectic relation between civilization and barbarism; the subversive movements dedicated to maintain the reverence for the book and the philosophical-literary tradition; the intertextuality and the prominent role of the Bible as the Book of books. In conclusion, one can say that both authors, despite various common points – especially with regard to their anti-totalitarian commitment – differ, in particular, in terms of their political orientation and the focus of their cultural critic

  4. Anthropologie visuelle des mal-logés de la place de la Réunion

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    Sylvaine Conord

    2008-07-01

    Full Text Available Ce quartier dans les années 90 était considéré comme un lieu majoritairement populaire. Je le prends aujourd’hui comme exemple car il reste emblématique d’un Paris populaire en mutation. Cette étude est aussi toujours actuelle de par son sujet. La question des mal-logés en région parisienne n’est pas résolue: des milliers de foyers attendent l’attribution d’un logement décent après avoir déposé leur demande depuis de nombreuses années auprès des services publics, de nombreuses familles vivent en hôtel meublé. Au-delà d’une observation participante ce travail pose la question «d’une sociologie militante» qui prend parti à travers des témoignages et la participation active de l’observatrice aux diverses actions.

  5. El mal en las palabras: El hombre tempestad Evil in Words: El hombre tempestad

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    Ángela Uribe Botero

    2009-06-01

    Full Text Available En este trabajo se muestra cómo es posible que el mal pueda estar contenido en cierta forma de hablar. En términos de J. L. Austin, y de la mano de Hannah Arendt, a la luz de un ejemplo tomado de la historia colombiana, se ilustra la fuerza ilocucionaria de ciertas expresiones. El ejemplo está contenido en uno de los discursos más célebres del expresidente colombiano Laureano Gómez Castro. El texto concluye mostrando cómo, con los enunciados que Gómez emite, antes que cumplir las promesas que hace en su discurso o describir una serie de cosas, miente y en tanto hace esto, cambia el mundo en la forma de actuar sobre él con maldad.This text shows how evil can be contained in certain way of speaking. In terms of J. L. Austin, and considering Hannah Arendt, with the help of an example taken from recent Colombian history, it illustrates the ilocucionary force of certain expressions. The example is found in one of the most important speeches of former president Laureano Gómez Castro. The text concludes by showing how, Gómez, rather than maintaining promises that he makes in his speech or describing a series of things, lies, and in so doing, changes the world through his way of evilly acting above it.

  6. Albertet, “En amor trob tantz de mals seignoratges” (BdT 16.13

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    Francesca Sanguineti

    2008-12-01

    Full Text Available The article provides a commentary and a new critical edition of Albertet’s poem “En amor trob tantz de mals seignoratges”, in which the troubadour praises some of the most courtly ladies of his time. The poem can be linked to the genre of the collective eulogy, where the enumerated ladies are praised essentially for political reasons, since the commendation is clearly addressed to the men hidden behind them: famous specimena of this genre are the ‘tournoiements des dames’ by Huon d’Oisy and Richard de Semilli and Raimbaut de Vaqueiras’ “Carros” (BdT 392.32. Albertet’s song starts with a misogynic tone, since the poet declares that celebrating or loving ladies is worthless, given their immoral behaviour, and with a polemic against the strict rules of courtly love. This misogyny, as is further discovered, is a rhetorical device to praise women as well as a tool to renew the genre of the love song from a thematic point of view.

  7. Optimization and therapeutic effects of PDT mediated by ALA and MAL in the treatment of cutaneous malignant lesions: A comparative study.

    Science.gov (United States)

    Lima, Cassio Aparecido; Goulart, Viviane Pereira; Bechara, Etelvino Jose Henriques; Correa, Luciana; Zezell, Denise Maria

    2016-12-01

    5-aminolevulinic acid (ALA) and its methylated ester (MAL) are the most common topical agents used in photodynamic therapy (PDT) as precursors of the photosensitizer protoporphyrin IX (PpIX). The induction of newly PpIX depends on incubation time of each photosensitizer in the tissue and the presence of high intralesional porphyrin levels is an important parameter for the PDT effectiveness. This study used laser-induced fluorescence (LIF) spectroscopy to evaluate the optimum time to light exposure of PDT mediated by ALA (20% w/w) and MAL (10% w/w) to treat malignant lesions precursors of cutaneous squamous cell carcinoma induced in mice. The therapeutic effects obtained by optimized ALA- and MAL-PDT were assessed 10 and 20 days after treatments. Higher PpIX levels were evidenced in the lesions photosensitized by ALA than MAL and according to LIF measurements the PDT irradiation was performed, respectively, at 300 and 330 minutes after ALA and MAL incubation. Histopathological analysis evidenced necrosis and epithelial atrophy after 10 days of PDT using both prodrugs, as well as reepitelization and collagen deposition at 20 days. Thus, despite the distinct concentration of ALA and MAL used in the formulation of each photosensitizing cream, PDT mediated by both photosensitizing agents obtained similar therapeutic outcomes. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. The Wave Energy Sector

    DEFF Research Database (Denmark)

    Kofoed, Jens Peter

    2017-01-01

    shaped by the development, research, and teaching that we have carried out at the Wave Energy Research Group at Aalborg University over the past decades. It is our belief and experience that it would be useful writing and compiling such a handbook in order to enhance the understanding of the sector......This Handbook for Ocean Wave Energy aims at providing a guide into the field of ocean wave energy utilization. The handbook offers a concise yet comprehensive overview of the main aspects and disciplines involved in the development of wave energy converters (WECs). The idea for the book has been...

  9. Private Sector Involvement

    DEFF Research Database (Denmark)

    Hansen, Annette Skovsted

    New and independent donors are adding their own twist to the experiences of receiving ODA and their examples are already inspiring the DAC, UN, and other multiple- and bilateral aid relationships. Rather than competition among development paradigms, I see negotiations of ideas of development and ...... and a co-existence of a multiplicity of approaches. I will argue that a trend of new and old actors inspiring each other will continue and the explicit focus on private sector development is just a first outcome....

  10. [Materials for construction sector].

    Science.gov (United States)

    Macchia, C

    2012-01-01

    The construction sector is characterized by high complexity due to several factors. There are a lot of processes within the building sites and they need the use of different materials with the help of appropriate technologies. Traditional materials have evolved and diversified, meanwhile new products and materials appeared and still appear, offering services which meet user needs, but that often involve risks to the health of workers. Research in the field of materials, promoted and carried out at various levels, has led to interesting results, encoded in the form of rules and laws.

  11. GLOBALIZATION IN TOURISM SECTOR

    Directory of Open Access Journals (Sweden)

    Mariana LUPAN

    2007-06-01

    Full Text Available The paper points to recent developments in the tourism sector and highlights the leading factors of the internationalization of tourists travel and of tourism services, including information technologies, as well as the internationalization of hotel and tourism enterprises. Without neglecting the huge subsector of small and medium-sized enterprises, it describes typical features related to the composition of the labour force and to working conditions. It raises questions concerning the difficulties faced by the sector in attracting and retaining skilled workers in enhancing the skills of newcomers to the labour market in order to stabilize the sector’s labour force, while increasing the productivity of enterprises and the quality of services. Particular emphasis is put on new forms of management entailing new skills requirements, with a general tendency towards increased worker responsibility in an environment of flat hierarchies, multiskilling and teamwork.

  12. Figurações do "mal" e do "maligno" no Grande sertão: veredas

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    Marcus V. Mazzari

    2008-12-01

    Full Text Available Este texto constitui o segundo capítulo de um estudo sobre a trajetória de Riobaldo em sua oscilação entre o pacto fáustico e a tradição do chamado "romance de formação e desenvolvimento" (Bildungs- und Entwicklungsroman. Partindo de um trecho do romance O homem sem qualidades em que Musil discute os obstáculos que se colocam à arte da narrativa no século XX (antecipando reflexões teóricas de Adorno, Auerbach, Rosenfeld etc., o estudo enfoca, no primeiro capítulo, traços do Grande sertão que o vinculariam a um épico mais primitivo. Também se estabelecem aqui algumas relações com o Doutor Fausto de Thomas Mann, romance que tem igualmente no pacto demoníaco o seu motivo nuclear. Quanto ao presente texto, está voltado às formas e imagens que o relato de Riobaldo dispensa aos conceitos de "mal" e de "maligno" (assim como ao seu entrelaçamento. Em seguida, enfoca a personagem de Hermógenes, que encarna uma espécie de principium maleficum que dificilmente encontra paralelo na literatura ocidental. Para expor essa especificidade da personagem rosiana, o estudo procede por fim a uma comparação com a representação do Mal (e sua correspondente personagem no romance barroco Simplicissimus, de Grimmelshausen.This text represents the second chapter of a study on Robaldo's trajectory during his oscilation between the faustian bargain and the tradition of the so-called "Bildungsroman" (Bildungs - und Entwicklungsroman. Taking an excerpt of the novel The Man Without Qualities, in which Musil discusses the obstacles imposed on 20th century narrative art, as a starting point (and putting forth theorethical reflections by Adorno, Auerbach, Rosenfeld etc., the essay focuses, in the first chapter, on the features of Guimarães Rosa's novel The Devil to Pay in the Backlands that would connect it to a more primitive epic. Here, some relationships with Thomas Mann's Doctor Faustus, which also has the diabolic pact as a central motif, are

  13. Esplenoportografia em pacientes com hepatoesplenomegalia acompanhada de infecção malárica

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    Sérgio Gomes Coutinho

    1967-08-01

    Full Text Available Foi praticada a esplenoportografia em 10 pacientes portadores de malária, sendo a infecção causada pelo P. falciparum em 5 casos, pelo P. vivax em 3 casos e pela associação de ambos os plasmódios em outros 2 casos. Em 2 dêsses 10 casos, havia associação da malária com a esquistossomose mansoni. Os resultados obtidos demonstraram: 1 tortuosidade da veia esplênica em 4 casos. Êste fato é explicado pela hepatoesplenomegalia, restringindo a distância entre os hilos dos dois órgãos e portanto causando uma retração da veia esplênica em seu sentido longitudinal; 2 discreta pobreza das ramificações portais intrahepálicas, representada pela ausência ou deficiência de contrastação dos ramos aicotômicos portais mais finos. Esta imagem foi encontrada em 7 casos, e pode ser explicada pela vasoconstricção das ramificações portais, relatadas por Skirrow em Macacus rhesus infectados pelo P. knowlesi (19, 20. Outra explicação mais simplista para êste fato está relacionada com a grande diluição do contraste ao atingir os ramos portais mais finos, tendo em vista a ampliação do leito vascular, em virtude da grande hepatoesplenomegalia - sendo de nocar-se que a hepatomegalia era proeminente em 6 dos casos; 3 o hepatograma, além dos aspectos mencionados, mostrou um aumento apreciável e universal do fígado em 6 casos cujos limites podiam ser apreciados em todos os sentidos, contrastando de certo modo com o hepatograma de esquistossomose hepatoesplênica, em que predominam alterações vasculares intrahepáticas, com aspectos sugestivos de peripileflebite esquistossomótica. Parece que êsses resultados não foram influenciados pela espécie do plasmódio em causa, isto ê, o falciparum ou o vivax. Nove dos dez pacientes foram submetidos à punção biópsia hepática, sendo que as alterações histopatológicas observadas foram bastante discretas, estando portanto em acordo com as pequenas modificações evidenciadas no

  14. Simulação no contexto de problemas mal estruturados

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    Antônio Sérgio de Souza

    1994-12-01

    Full Text Available Simulação é atualmente reconhecida como uma poderosa ferramenta no projeto, análise e operação de sistemas produtivos. Apesar dos avanços recentes em linguagens de simulação, interfaces gráficas e geradores de aplicações, simulação ainda é uma técnica cara e pouco eficiente. Discute-se no texto algumas causas deste fato no contexto de problemas mal estruturados, como é o caso de planejamento e controle da produção. Discute-se a necessidade de realização da modelagem conceitual, não apenas como um passo estanque no processo de simulação, mas de forma progressiva e dinâmica, durante todo o ciclo de vida do projeto, servindo como uma interface entre os contextos real e de simulação.Simulation is now recognized as powerful tool in project, analyses and operation of produtive systems. Although the recent advances in simulation languages, graphical interfaces and in generating applications, simulation is still an expensive and not so efficient technique. In this text we dicuss some reasons for this in the context of not well strutured problems, asit is the case of production planning and control. It is also dicussed the necessity of developing the conceptual modeling of the real system, not only as a separated step in the simulation process, but in a progressive and dynamic way, during the project's life cycle as an interface between the real system and simulation.

  15. Fenomena Bangunan Mal dan Pengalaman Estetika Bagi Masyarakat Urban di Jakarta

    Directory of Open Access Journals (Sweden)

    Amarena Nediari

    2013-10-01

    Full Text Available Mall building has become part of the urban living’s lifestyle. Going to the mall is an independent necessity without any emotional bond with others. As a public area, mall has been trying to fulfill urban communities’ needs such as to enlarge employment opportunities as well as to provide an entertainment center for visitors. For most of urban communities, mall is considered to be a solution for all members of family. It is one destination for all. Mall elements consist of anchor, secondary anchor, street mall, and landscaping. They are built in a perfect composition in order to emphasize the main purpose of a mall building as a modern place for trading. Interior design in a mall building is not only to apply a finishing treatment but also to give an aesthetic experience to the visitors. The excitement of being surrounded by beautiful material, attractive colors in luxurious building are some of the impact that gives an aesthetic experience in mall buildings. This meant to attract customer to purchase the product. The phenomenon of mall building is that although the function of mall building has met the urban communities’ demand it also has used the green spaces and spoiled the water absorption.  In order to solve the problems that suitable for this situation, designing an integrated mal with green building concept should be the solution. The solution should be supported with government regulation based on the awareness of environmental friendly, combining a mall building with open space with well designed of landscapingwill offer a new place to gather for urban communities.  

  16. Readaptation of the Vestibulo-Ocular Reflex Relieves the Mal de Debarquement Syndrome

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    Mingjia eDai

    2014-07-01

    Full Text Available The Mal de Debarquement Syndrome (MdDS, a continuous feeling of swaying, rocking and/or bobbing, generally follows travel on the sea. The associated symptoms cause considerable distress. The underlying neural mechanisms are unknown, and to date there have been no effective treatments for this condition. Results in monkeys and humans suggested that MdDS was caused by maladaptation of the vestibulo-ocular reflex (VOR to roll of the head during rotation. We studied twenty-four subjects with persistent MdDS (3 males, 21 females; 19.1 ± 33 months. Physical findings included body oscillation at 0.2Hz, oscillating vertical nystagmus when the head was rolled from side-to-side in darkness, and unilateral rotation during the Fukuda stepping test. We posited that the maladapted rocking and the physical symptoms could be diminished or extinguished by readapting the VOR. Subjects were treated by rolling the head from side-to-side while watching a rotating full-field visual stimulus. Seventeen of the twenty-four subjects had a complete or substantial recovery on average for approximately one year. Six were initially better, but the symptoms recurred. One subject did not respond to treatment. Thus, readaptation of the VOR has led to a cure or substantial improvement in 70% of the subjects with MdDS. We conclude that the adaptive processes associated with roll-while-rotating are responsible for producing MdDS, and that the symptoms can be reduced or resolved by readapting the VOR.

  17. Readaptation of the vestibulo-ocular reflex relieves the mal de debarquement syndrome.

    Science.gov (United States)

    Dai, Mingjia; Cohen, Bernard; Smouha, Eric; Cho, Catherine

    2014-01-01

    The mal de debarquement syndrome (MdDS), a continuous feeling of swaying, rocking, and/or bobbing, generally follows travel on the sea. The associated symptoms cause considerable distress. The underlying neural mechanisms are unknown, and to date there have been no effective treatments for this condition. Results in monkeys and humans suggested that MdDS was caused by maladaptation of the vestibulo-ocular reflex (VOR) to roll of the head during rotation. We studied 24 subjects with persistent MdDS (3 males, 21 females; 19.1 ± 33 months). Physical findings included body oscillation at 0.2 Hz, oscillating vertical nystagmus when the head was rolled from side-to-side in darkness, and unilateral rotation during the Fukuda stepping test. We posited that the maladapted rocking and the physical symptoms could be diminished or extinguished by readapting the VOR. Subjects were treated by rolling the head from side-to-side while watching a rotating full-field visual stimulus. Seventeen of the 24 subjects had a complete or substantial recovery on average for approximately 1 year. Six were initially better, but the symptoms recurred. One subject did not respond to treatment. Thus, readaptation of the VOR has led to a cure or substantial improvement in 70% of the subjects with MdDS. We conclude that the adaptive processes associated with roll-while-rotating are responsible for producing MdDS, and that the symptoms can be reduced or resolved by readapting the VOR.

  18. MalHaploFreq: A computer programme for estimating malaria haplotype frequencies from blood samples

    Directory of Open Access Journals (Sweden)

    Smith Thomas A

    2008-07-01

    Full Text Available Abstract Background Molecular markers, particularly those associated with drug resistance, are important surveillance tools that can inform policy choice. People infected with falciparum malaria often contain several genetically-distinct clones of the parasite; genotyping the patients' blood reveals whether or not the marker is present (i.e. its prevalence, but does not reveal its frequency. For example a person with four malaria clones may contain both mutant and wildtype forms of a marker but it is not possible to distinguish the relative frequencies of the mutant and wildtypes i.e. 1:3, 2:2 or 3:1. Methods An appropriate method for obtaining frequencies from prevalence data is by Maximum Likelihood analysis. A computer programme has been developed that allows the frequency of markers, and haplotypes defined by up to three codons, to be estimated from blood phenotype data. Results The programme has been fully documented [see Additional File 1] and provided with a user-friendly interface suitable for large scale analyses. It returns accurate frequencies and 95% confidence intervals from simulated dataset sets and has been extensively tested on field data sets. Additional File 1 User manual for MalHaploFreq. Click here for file Conclusion The programme is included [see Additional File 2] and/or may be freely downloaded from 1. It can then be used to extract molecular marker and haplotype frequencies from their prevalence in human blood samples. This should enhance the use of frequency data to inform antimalarial drug policy choice. Additional File 2 executable programme compiled for use on DOS or windows Click here for file

  19. Comprometimento pulmonar na malária (revisão Pulmonary involvement in malaria

    Directory of Open Access Journals (Sweden)

    Marcos Boulos

    1993-02-01

    Full Text Available Com uma incidência de 3 a 10% dos casos e letalidade próxima a 70%, o comprometimento pulmonar constitui uma das manifestações mais graves da malária por Plasmodium falciparum. Embora sua patogênese não esteja perfeitamente esclarecida, reconhece-se que a hiperativação do sistema imune por antígenos liberados pelo Plasmodium falciparum desempenhe um importante papel no desencadeamento e agravamento das lesões. A estrutura alvo parece ser o endotélio capilar, responsável pelo fluxo de líquidos para o espaço intersticial. Essas células são ativadas por ação de citocinas, produzidas por linfócitos e macrófagos durante a resposta imune, e passam a expressar em sua membrana celular receptores e moléculas de aderência que facilitam a sequestração de eritrócitos parasitados e também a aderência de células capazes de produzir mediadores inflamatórios. A reação inflamatória e a lesão endotelial que se seguem, juntamente com as alterações hemodinâmicas induzidas pelo bloqueio capilar devido ao acúmulo local de eritrócitos e células inflamatórias causam alterações de permeabilidade vascular e, consequentemente, acúmulo de líquido nos espaços intersticiais e alvéolos. Nos casos mais graves, as manifestações clínicas assemelham-se às do quadro da Síndrome do desconforto respiratório do adulto. Comprometimento pulmonar grave pode se instalar rapidamente em qualquer estágio da evolução clínica da malária, mesmo após a cura parasitológica, desconhecendo-se os fatores desencadeantes. Hiperparasitismo, insuficiência renal e gravidez constituem fatores predisponentes. O prognóstico dependerá da rapidez com que o diagnóstico for estabelecido e o correto tratamento instituído. Além do tratamento instituído contra o parasita, especial atenção deverá ser dispensada à monitorização hemodinâmica, se possível através de cateter de Swan-Ganz, à manutenção de adequada oxigenação e balanço h

  20. Regional transport sector mitigation options

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Peter [EECG Consultants, Gaborone (Botswana)

    1998-10-01

    The rationale for conducting climate change mitigation studies in the transport sector is on the premise that: The transport sector is the second largest consumer of fossil fuels in the region; The regional transport sector is an area with high opportunity for infrastructural development under UNFCCC financial mechanism; The regional transport sector is crucial in the SADC region for trade and coupled with the Trade Protocol will play a major role in development hence the need to make it efficient in terms of energy demand and provision of services; The sector offers many mitigation options but with a challenge to evaluate their energy saving and GHG saving potential and yet there is need to quantify possible emission reduction for possible future emission trading. This is also a sector with potential to qualify for financing through Clean Development Mechanism (CDM) recently stipulated in the Kyoto Protocol. (au)

  1. SECTORAL SHARES AND ECONOMIC GROWTH

    DEFF Research Database (Denmark)

    Ahmad, Nisar; Naveed, Amjad; Naz, Amber

    2013-01-01

    believe that structural change is an unimportant side effect of the economic development. On the contrary, economists associated with the World Bank and some others posit that growth is brought about by the changes in sectoral composition. The objective of this study is to empirically test...... the relationship between sectoral shares and economic growth by using the panel data for 20 developed countries. The results of the granger causality suggest that both services and agriculture sectors do granger cause economic growth, whereas industrial sector does not granger cause growth. Reverse causality does...... not hold for any of the three sectors. The results of Barro and Non-Barro regressions along with the set of control variables have suggested that services sector is negatively affecting growth, whereas both industrial and agriculture shares are positively affect economic growth....

  2. Cross-sectoral Innovation

    DEFF Research Database (Denmark)

    Petersen, Lene Ekholm

    2016-01-01

    workers like nurses, therapists, teachers and educators. The study indicates that the importance of the welfare worker has been overlooked in past discussions about the influence of talent on innovation and economic growth. Cooke (2013) sees the core process of innovation as knowledge recombination...... to the importance of joint learning in setups where experts and non-experts can meet and learn from each other in order to improve and innovate on the products. Something you could call a setup of temporary communities of practice (Gherardi and Nicolini, 2003). The case also shows that there is great interest......Cross-sectoral Innovation – The Challenge of Knowledge Sharing Keywords: Knowledge sharing, clusters, ANT, Communities of Practice, welfare technology With regard to meeting the challenges of the knowledge economy, a mode 2 of production (Gibbons et al., 2010), collaboration between actors across...

  3. Sector y empresa informal

    Directory of Open Access Journals (Sweden)

    Marcos Membreño Idiáquez

    1998-12-01

    Full Text Available Detrás de su aparente heterogeneidad, las distintas teorías sobre el sector y la empresa informal tienen en común importantes presupuestos epistemológicos y metodológicos. Esto se debe a que todos los teóricos de la informalidad han ido a llenar sus cántaros conceptuales a una misma y única fuente: la noción de informalidad propuesta originalmente por Keith Hart (1971 en los años setenta. Pero cuando hicieron suya la -noción de informalidad, los seguidores de Hart no pudieron despojarla nunca de las inconsistencias teóricas que le eran inherentes desde su origen, a pesar de haberla traducido y reformulado en el lenguaje propio de sus respectivas escuelas de pensamiento. Tal es la tesis que defiende el autor de este artículo.

  4. Energy Sector Market Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Arent, D.; Benioff, R.; Mosey, G.; Bird, L.; Brown, J.; Brown, E.; Vimmerstedt, L.; Aabakken, J.; Parks, K.; Lapsa, M.; Davis, S.; Olszewski, M.; Cox, D.; McElhaney, K.; Hadley, S.; Hostick, D.; Nicholls, A.; McDonald, S.; Holloman, B.

    2006-10-01

    This paper presents the results of energy market analysis sponsored by the Department of Energy's (DOE) Weatherization and International Program (WIP) within the Office of Energy Efficiency and Renewable Energy (EERE). The analysis was conducted by a team of DOE laboratory experts from the National Renewable Energy Laboratory (NREL), Oak Ridge National Laboratory (ORNL), and Pacific Northwest National Laboratory (PNNL), with additional input from Lawrence Berkeley National Laboratory (LBNL). The analysis was structured to identify those markets and niches where government can create the biggest impact by informing management decisions in the private and public sectors. The analysis identifies those markets and niches where opportunities exist for increasing energy efficiency and renewable energy use.

  5. Isolation of Mal d 1 and Api g 1 - specific recombinant antibodies from mouse IgG Fab fragment libraries - Mal d 1-specific antibody exhibits cross-reactivity against Bet v 1.

    Science.gov (United States)

    Haka, Jaana; Niemi, Merja H; Iljin, Kristiina; Reddy, Vanga Siva; Takkinen, Kristiina; Laukkanen, Marja-Leena

    2015-05-27

    Around 3-5% of the population suffer from IgE-mediated food allergies in Western countries and the number of food-allergenic people is increasing. Individuals with certain pollen allergies may also suffer from a sensitisation to proteins in the food products. As an example a person sensitised to the major birch pollen allergen, Bet v 1, is often sensitised to its homologues, such as the major allergens of apple, Mal d 1, and celery, Api g 1, as well. Development of tools for the reliable, sensitive and quick detection of allergens present in various food products is essential for allergic persons to prevent the consumption of substances causing mild and even life-threatening immune responses. The use of monoclonal antibodies would ensure the specific detection of the harmful food content for a sensitised person. Mouse IgG antibody libraries were constructed from immunised mice and specific recombinant antibodies for Mal d 1 and Api g 1 were isolated from the libraries by phage display. More detailed characterisation of the resulting antibodies was carried out using ELISA, SPR experiments and immunoprecipitation assays. The allergen-specific Fab fragments exhibited high affinity towards the target recombinant allergens. Furthermore, the Fab fragments also recognised native allergens from natural sources. Interestingly, isolated Mal d 1-specific antibody bound also to Bet v 1, the main allergen eliciting the cross-reactivity syndrome between the birch pollen and apple. Despite the similarities in Api g 1 and Bet v 1 tertiary structures, the isolated Api g 1-specific antibodies showed no cross-reactivity to Bet v 1. Here, high-affinity allergen-specific recombinant antibodies were isolated with interesting binding properties. With further development, these antibodies can be utilised as tools for the specific and reliable detection of allergens from different consumable products. This study gives new preliminary insights to elucidate the mechanism behind the pollen

  6. Formal sector subcontracting and informal sector employment in Indian manufacturing

    NARCIS (Netherlands)

    Moreno-Monroy, A.I.; Pieters, J.; Erumban, A.A.

    2014-01-01

    Using nationally representative survey dta of Indian manufacturing enterprises spanning the period 1995-2006, we analyze the link between formal sector subcontracting and informal sector employment. A novelty in our analysis is that this relationship is allowed to differ between modern and

  7. Brucella TIR-like protein TcpB/Btp1 specifically targets the host adaptor protein MAL/TIRAP to promote infection.

    Science.gov (United States)

    Li, Wenna; Ke, Yuehua; Wang, Yufei; Yang, Mingjuan; Gao, Junguang; Zhan, Shaoxia; Xinying, Du; Huang, Liuyu; Li, Wenfeng; Chen, Zeliang; Li, Juan

    2016-08-26

    Brucella spp. are known to avoid host immune recognition and weaken the immune response to infection. Brucella like accomplish this by employing two clever strategies, called the stealth strategy and hijacking strategy. The TIR domain-containing protein (TcpB/Btp1) of Brucella melitensis is thought to be involved in inhibiting host NF-κB activation by binding to adaptors downstream of Toll-like receptors. However, of the five TIR domain-containing adaptors conserved in mammals, whether MyD88 or MAL, even other three adaptors, are specifically targeted by TcpB has not been identified. Here, we confirmed the effect of TcpB on B.melitensis virulence in mice and found that TcpB selectively targets MAL. By using siRNA against MAL, we found that TcpB from B.melitensis is involved in intracellular survival and that MAL affects intracellular replication of B.melitensis. Our results confirm that TcpB specifically targets MAL/TIRAP to disrupt downstream signaling pathways and promote intra-host survival of Brucella spp. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. A formação humana e a incapacidade de pensar: considerações sobre o problema do mal em Hannah Arendt

    Directory of Open Access Journals (Sweden)

    Marcos Alexandre Alves

    2017-08-01

    Full Text Available Este artigo pretende apresentar o tema da formação humana conectado à incapacidade de pensar, tecendo considerações sobre o problema do mal no pensamento de Hannah Arendt. A autora é conhecida como pensadora da política que concentrou atenção especial ao problema do mal que assolou o mundo na primeira metade do século XX. A partir da análise de Origens do Totalitarismo, de 1951, e de Eichmann em Jerusalém: um relato sobre a banalidade do mal, de 1963, pretende-se refletir acerca dos mecanismos que produzem o adormecimento da capacidade de pensar frente à necessidade da formação humana. A partir dessa análise, se perceberá que o problema do mal assume um viés radical, uma possibilidade de destruição completa do humano. Na análise do caso Eichmann, Arendt percebeu que o réu agia banalmente, manifestando sua incapacidade de pensar, o que tornou possível a normalização da insensibilidade frente o diferente. Portanto, a banalidade do mal implica na incapacidade de pensar, uma ameaça sempre constante à formação humana

  9. Malária pulmonar: aspectos na tomografia computadorizada de alta resolução - relato de caso

    Directory of Open Access Journals (Sweden)

    Rodrigues Rosana

    2004-01-01

    Full Text Available Neste trabalho é relatado o caso de paciente do sexo masculino, de 38 anos de idade, que desenvolveu quadro de malária com comprometimento pulmonar. A tomografia computadorizada de alta resolução evidenciou espessamento de septos interlobulares e de bainhas peribroncovasculares, com áreas esparsas de atenuação em vidro fosco e de consolidações, além de derrame pleural bilateral, aspectos compatíveis com edema pulmonar. O paciente recebeu tratamento específico, evoluindo bem e tendo alta 11 dias após a internação.

  10. Identidade feminina e história em Arráncame la vida e Mal de amores

    OpenAIRE

    Troian, Aline Dalpiaz

    2013-01-01

    O presente trabalho trata da representação de identidades femininas nos romances Arráncame la vida (1985) e Mal de amores (1996), de Ángeles Mastretta, a partir dos pressupostos da crítica feminista. Além disso, analisa de que modo o contexto social e histórico mexicano atua nesse processo de formação identitária das personagens Emila e Catalina, seja influenciando ou propiciando determinados movimentos, ou mesmo, alterando a percepção das personagens acerca de suas identidades...

  11. La représentation de la femme dans Arrancame la vida et Mal de amores d'Angeles Mastretta

    OpenAIRE

    Vanguelova, Maria

    2010-01-01

    On the basis of two novels by Ángeles Mastretta, Arráncame la vida and Mal de amores - whose publication is separated by a ten years interval – I have attempted to show how the female character responds to a specific project of representation and writing. The present thesis emphasises both the variety of characters in the two novels and the constants that allow establishing a "system of characters" corresponding to the exploration of the subject matter dear to the novelist: the status of wome...

  12. EDI in the Public Sector

    DEFF Research Database (Denmark)

    Falch, Morten

    1998-01-01

    Introduction of EDI in the public administration is apriority for the Danish Government. EDI is both seen as a catlyst for development towards an information society ans as a means for more efficient use of scarce resources. EDI in the banking sector and the retail sector is reviewed, drivers...... and barriers discussed nad Danish public policy initiatieves assessed....

  13. Sectoral profiles of working conditions

    NARCIS (Netherlands)

    Houtman, I.L.D.; Andries, F.; Berg, R. van den; Dhondt, S.

    2002-01-01

    This report looks at trends in working conditions across different sectors Over the period 1995-2000. Basing its findings on the Third European Survey on Working Conditions (2000) in the 15 EU Member States and Norway, it examines the quality of working life in eighteen different sectors. It

  14. The Danish Social Housing Sector

    DEFF Research Database (Denmark)

    Nielsen, Rikke Skovgaard; Haagerup, Christian Deichmann

    2017-01-01

    With Denmark faring reasonably well through the global financial crisis, the policy changes to the social housing sector caused by the crisis have been limited. Nevertheless, changes have taken place nonetheless both in terms of policy and in the residential composition of the sector which policies...

  15. Tuberculose ostéoarticulaire (mal de Pott exclu): à propos de 120 cas à Abidjan

    Science.gov (United States)

    Gbané-Koné, Mariam; Koné, Samba; Ouali, Boubacar; Djaha, Kouassi Jean -Mermoz; Akoli, Ekoya Ondzala; Nseng, Ingrid Nseng; Eti, Edmond; Daboiko, Jean Claude; Touré, Stanislas André; Kouakou, N'zué Marcel

    2015-01-01

    Introduction La tuberculose ostéoarticulaire (TOA) représente 2 à 5% de l'ensemble des tuberculoses. Elle demeure d'actualité surtout dans les pays à forte endémicité tuberculeuse. L'objectif était de déterminer la prévalence, les aspects topographiques, radiologiques de la TOA en milieu hospitalier ivoirien. Méthodes Les auteurs rapportent une expérience de 11 ans, à travers une étude rétrospective de 120 dossiers de patients atteints de la tuberculose ostéoarticulaire (le mal de Pott est exclu de cette étude). N'ont pas été inclus dans l’étude les dossiers ne comportant pas d'imagerie. Résultats L'atteinte extra vertébrale représentait 09,2% de la tuberculose ostéoarticulaire. Il s'agissait de 54 hommes et 66 femmes, l’âge moyen était de 43,13 ans. On notait 123 cas d'ostéoarthrites, et 8 cas d'ostéites des os plats. L'atteinte des membres inférieurs prédominait dans 91,87% des cas. La hanche était la première localisation (45,04%), suivie du genou (25,19%). Les atteintes étaient multifocales dans 20% des cas. L'atteinte osseuse était associée à une tuberculose pulmonaire dans 05,83% des cas. Des localisations inhabituelles ont été rapportées: poignet (n = 2), branches ischiopubiennes (n = 4), atteinte sternoclaviculaire (n = 4), médiopieds (n = 2). Les lésions radiologiques étaient avancées (stades III et IV) dans 55,73% des cas. A la TDM, la prévalence des abcès était de 77%. Un geste chirurgical a été réalisé sur 16 articulations (2 épaules, 13 genoux, une cheville). Conclusion La TOA des membres est peu fréquente contrairement à l'atteinte vertébrale. La hanche est la principale localisation. Le retard au diagnostic explique l’étendue des lésions anatomoradiologiques. PMID:26587129

  16. EJERCICIO Y LA DETECCION DEL MAL AGUDO DE MONTAÑA GRAVE

    Science.gov (United States)

    Garófoli, Adrián; Montoya, Paola; Elías, Carlos; Benzo, Roberto

    2012-01-01

    El Mal Agudo de Montaña (MAM) es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral) pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2 700m y 4 300m en 63 sujetos que ascendían al cerro Aconcagua (6 962m). Se consideró desaturación de oxígeno con ejercicio a una disminución >=5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. 6 sujetos presentaron MAM grave (9.5%) y requirieron evacuación. La saturación de oxígeno en reposo a 2 700m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2 700m más la saturación inapropiada en reposo a 4 300m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave. PMID:20228017

  17. Efeitos benéficos e maléficos da malva sylvestris

    Directory of Open Access Journals (Sweden)

    Ana Carolina Locatelli Ecker

    2016-04-01

    Full Text Available Objetivo. Revisar os efeitos benéficos e maléficos da Malva sylvestris para a saúde humana. Materiais e métodos. Foi realizada uma busca na base de dados BIREME, em setembro de 2014, por meio das pala­vras chaves malva AND sylvestris. Foram incluídos os artigos na língua inglesa e portuguesa sem limite de tempo. Foram excluídos os estudos repetidos e aqueles que não abordavam o tema. Resultados. Atra­vés da busca realizada, foram encontrados 56 artigos, destes, foram excluídos dois repetidos, um por encontrar-se no idioma chinês e, 41 por estarem fora do tema (benefícios para animais e solo, proprie­dades químicas da erva, pesquisa em campo de determinadas regiões do mundo abrangendo índices de utilização de muitas espécies de plantas para fins medicinais. Assim, foram, incluídos 12 artigos. Com grande importância terapêutica, a erva tem sido utilizada na área da saúde em geral para inflamações internas e externas, fins quimio-preventivos e antissépticos. Também alivia secreções como catarros, congestionamento das vias respiratórias e age como calmante no sistema neurológico. Segundo pes­quisas, o chá de malva apresenta resultados mais vantajosos do que tratamentos medicamentosos e é uma das mais utilizadas como auto-medicação. Conclusão. A Malva sylvestris é utilizada para muitos fins benéficos para o ser humano desde tempos remotos, mas sua comprovação científica tem ocorrido atualmente, evidenciando a veracidade de suas vantagens na saúde e no tratamento de patologias.

  18. Mal de Chagas: la enfermedad de la pobreza, Casas de fuego (1995

    Directory of Open Access Journals (Sweden)

    Laura María Moratal Ibáñez

    2008-10-01

    Full Text Available El mal de Chagas es una enfermedad transmitida por un parásito a través de la picadura de un insecto o por sangre infectada. Existen en el mundo alrededor de 20.000.000 de personas con esta infección y se considera que hay 100.000.000 de personas en situación de riesgo por vivir en regiones donde el parásito es endémico. A pesar de estas cifras, pertenece al grupo de las llamadas “enfermedades olvidadas” por el poco interés de la industria farmacéutica en su investigación y en el desarrollo de nuevos productos para su tratamiento. La causa de este olvido puede intuirse observando el mapa de la localización de esta enfermedad que se corresponde exactamente con el mapa de la pobreza en América. Esta coexistencia es debida al hábito del insecto transmisor de vivir en los techos de paja y en las grietas de las paredes de las viviendas precarias. Eso significa que una forma de erradicarlo podría ser a través de la destrucción de su hábitat, quemando esas construcciones y reemplazándolas por viviendas dignas y habitables, de allí deriva la idea del título del filme Casas de Fuego. Esta película muestra cómo después de conocer las investigaciones de Carlos Chagas en Brasil, el médico argentino Salvador Mazza inicia sus investigaciones intentando completar el cuadro de esta enfermedad y además plasma la denodada lucha de un “sanitarista” interesado en salvar la vida de gente anónima y sin cultura para poder conseguir los subsidios y apoyos necesarios de una sociedad política hipócrita y una comunidad científica poco interesada.

  19. La fertilidad química del suelo y el «mal del ciprés» en Patagonia, Argentina Soil chemical fertility and austrocedrus chilensis disease in Patagonia, Argentina

    Directory of Open Access Journals (Sweden)

    Daniela Morales

    2011-12-01

    Full Text Available Los bosques de Austrocedrus chilensis sufren un proceso de mortalidad conocido como «mal del ciprés», cuya causa es aún discutida. Estudios previos sugieren la presencia de Phytophthora austrocedrae como agente causal de la mortalidad; sin embargo, el origen de la enfermedad continúa en estudio, dado que existen áreas afectadas no vinculadas con Phytophthora. El suelo, principalmente a través de sus características físicas y morfológicas, fue evidenciado como un factor asociado con la aparición y desarrollo de la enfermedad. En este trabajo, se evaluó la fertilidad química del suelo en relación al «mal del ciprés». Se seleccionaron cuatro sectores ubicados en el Valle «16 de Octubre» de la provincia del Chubut correspondientes a bosques puros y densos de A. chilensis. En cada sector se instalaron parcelas en áreas del bosque con síntomas severos de la enfermedad y en áreas sin síntomas. A su vez se incorporaron al estudio ocho parcelas control, ubicadas en bosques completamente sanos. Se tomaron muestras del horizonte A y se caracterizaron las propiedades químicas del suelo. No se encontraron deficiencias nutricionales y se observó un buen estado nutricional en todos los suelos analizados, aún en los bosques afectados, reflejándose en valores adecuados de materia orgánica, nitrógeno, bases y capacidad de intercambio catiónico. Se manifestaron diferencias entre los suelos bajo bosque afectado y suelos bajo bosques control en los contenidos de suma de bases, saturación de bases, calcio, pH NaF y fósforo. Estas diferencias podrían estar asociadas tanto a las condiciones de drenaje como a la presencia de Phytophthora.Austrocedrus chilensis forests suffer a widespread mortality locally known as «mal del ciprés» (cypress disease whose cause remains controversial. Previous studies suggested Phytophthora austrocedrae as the biotic cause; however, the origin of the mortality is still being studied since there are

  20. Estados de mal epiléptico na síndrome de Lennox-Gastaut: 1 — aspectos clínicos

    Directory of Open Access Journals (Sweden)

    José Geraldo Speciali

    1974-12-01

    Full Text Available Foram descritos os estados de mal epilépticos, convulsivos e não convulsivos, observados em 14 de 27 pacientes com síndrome de Lennox-Gastaut, regularmente seguidos em regime de ambulatório. Às manifestações não citadas na literatura foram atribuídas denominações baseadas na qualidade e eventual seqüência dos fenômenos observados, obedecidas as regras de terminologia constante na Classificação Internacional das Epilepsias. Foram discutidos a incidência, significado prognóstico e aspectos clínicos do estado de mal. Verificadas a elevada incidência e a freqüente atipia dos estados de mal epiléptico foi proposta uma classificação destas complicações.

  1. Securitización en el desierto: Una respuesta al terrorismo en Malí y en Níger, 2009 - 2013.

    OpenAIRE

    Guerrero Escobar, Laura Catalina

    2014-01-01

    Este es un estudio sobre las dinámicas de seguridad en Malí durante el periodo de 2009 a 2013. La investigación busca explicar de qué manera se ha dado un proceso de securitización de los grupos insurgentes frente a la amenaza generada por la proliferación de grupos armados no estatales en el territorio comprendido entre Malí y Níger. Se toma a Níger con el ánimo de ver la existencia de un subcomplejo regional de seguridad entre este país y Malí. De esta manera se afirma que el aumento de las...

  2. Mal3, the Schizosaccharomyces pombe homolog of EB1, is required for karyogamy and for promoting oscillatory nuclear movement during meiosis.

    Science.gov (United States)

    Polakova, Silvia; Benko, Zsigmond; Zhang, Lijuan; Gregan, Juraj

    2014-01-01

    Two successive rounds of chromosome segregation following a single round of DNA replication enable the production of haploid gametes during meiosis. In the fission yeast Schizosaccharomyces pombe, karyogamy is the process where the nuclei from 2 haploid cells fuse to create a diploid nucleus, which then undergoes meiosis to produce 4 haploid spores. By screening a collection of S. pombe deletion strains, we found that the deletion of 2 genes, mal3 and mto1, leads to the production of asci containing up to 8 spores. Here, we show that Mal3, the fission yeast member of the EB1 family of conserved microtubule plus-end tracking proteins, is required for karyogamy, oscillatory nuclear movement, and proper segregation of chromosomes during meiosis. In the absence of Mal3, meiosis frequently initiates before the completion of karyogamy, thus producing up to 8 nuclei in a single ascus. Our results provide new evidence that fission yeast can initiate meiosis prior to completing karyogamy.

  3. Abuso de drogas e transtornos alimentares entre mulheres: sintomas de um mal-estar de gênero?

    Directory of Open Access Journals (Sweden)

    Regina Helena Simões-Barbosa

    Full Text Available Resumo: O artigo discute o abuso de drogas e os transtornos alimentares sob as perspectivas críticas de gênero e do cuidado em saúde. Postula-se que o sofrimento subjetivo pode se expressar no corpo por meio das doenças psicossomáticas. Nessa perspectiva, a insaciável fome consumista das drogas ou de bens supérfluos, bem como o adoecimento pela fome voluntária em busca de um ideal de esbeltez, como na anorexia e bulimia, podem ser sintomas que denunciam o sofrimento feminino. Uma revisão nos campos da saúde coletiva e das teorias feministas destaca a magnitude dos fenômenos da medicalização e mercantilização da saúde presentes na psiquiatrização do mal-estar feminino. Na transição de gênero das sociedades capitalistas, as cobranças sociais pelo desempenho dos velhos e novos papéis femininos acentuam sentimentos de inadequação, traduzidos no mal-estar de gênero que circunda o abuso de drogas e os transtornos alimentares, analisados como patologias de protesto. Propõe-se o resgate do ideário do Programa de Assistência Integral à Saúde da Mulher, orientado pela integralidade, para enfrentar tais desafios.

  4. DESENVOLVIMENTO PROFISSIONAL, VIDA E CARREIRA: história de professores atingidos pelo mal-estar docente

    Directory of Open Access Journals (Sweden)

    Jurema Rosendo dos Santos

    2016-12-01

    Full Text Available Sabemos que têm sido crescentes as causas que tem levado ao mal-estar docente, pois o profissional da educação vem se adaptando a grandes pressões e demandas familiares, institucionais, do meio social etc. Este mal está vinculado ao ambiente de trabalho e como o professor encara isso perante a sociedade, afetando assim sua forma habitual de agir e ser normalmente, tanto em sua vida pessoal quanto profissional. Nessa perspectiva, este trabalho tem como base teórica autores como Gonçalves (1992, Esteve (1995, 1999 e Ferreira (2014 e tem como objetivo compreender como viviam os professores atingidos pelo mal-estar docente e como desenvolviam na carreira docente após esse mal. Para tanto, foi realizada uma pesquisa qualitativa e exploratória no ano de 2014, com dois professores da Educação Básica atingidos, entre os anos de 2006 e 2012, pelo mal-estar docente. Primeiramente, buscamos conhecer o perfil desses professores e para isso utilizamos o questionário; posteriormente, convidamo-los para falar das suas vidas através da entrevista narrativa, realizada individualmente. Dessa forma, os dados da pesquisa foram coletados, catalogados e analisados. As histórias contadas deram pistas de quão suscetíveis são esses sujeitos e o que desencadeou essa vulnerabilidade. Ainda, pudemos constatar diferenças no desenvolvimento profissional marcada, principalmente, pelas histórias de vida. Assim, as narrativas das histórias de vida foram indispensáveis para alcançar o objetivo proposto, pois através dessas foi possível conhecer a história pessoal e profissional do sujeito que narra e o entrelaçamento das vivências que vão delineando o desenvolvimento da carreira profissional docente. Palavras-chave: Mal-estar docente. Memória. História de vida. ABSTRACT  We know that the causes that have led to teacher malaise have been increasing, because the professional of education has been adapting to great pressures and also family

  5. Analytical Characterization of the Hydrolysis of Barley Malt Macromolecules During Enzymatic Degradation Over Time Using AF4/MALS/RI.

    Science.gov (United States)

    Rübsam, Heinrich; Becker, Thomas; Gastl, Martina

    2017-06-01

    The changes on the molecular weight distribution (MWD) and particle size distribution (PSD) during hydrolysis of barley malt in isothermal mashing procedures were determined using asymmetrical flow field flow fractionation coupled to multiangle laser light scattering and refractive index (AF4/MALS/RI). Mash/trials were focused on amylolytic starch degradation. Therefore, temperatures (65, 70, and 75 °C) were selected according to α- and β-amylases range of activity. Samples were produced by triplicate, tracking amylolytic processes over time periods from 10 to 90 min in each mash/trial. AF4/MALS/RI analysis demonstrated significant differences on the values of the MWD and PSD according to the temperature/time profile used. At mashing times over 30 min at a temperature of 65 °C, when α- and β-amylase are both active, the decrease over time of the MWD and PSD was significantly higher (P RI would be a powerful tool for breweries to adapt their technological processes to obtain beers with particular sensorial attributes. © 2017 Institute of Food Technologists®.

  6. Fingerpainting am Touchscreen. Fünf Mal- und Zeichen-Apps für Android-Tablets

    Directory of Open Access Journals (Sweden)

    Christoph Kaindel

    2015-06-01

    Full Text Available Malen auf dem Touchscreen eines Smartphones oder Tablets ist eine natürliche und intuitive Tätigkeit; anders als bei der Nutzung eines Grafiktabletts am PC gibt es so gut wie keine Umstellungsphase. Christoph Kaindel hat für uns fünf Mal- und Zeichen-Apps unter die Lupe genommen. Bereits für Kinder ist in den diversen Appstores eine große Zahl an einfachen Mal-Apps zu finden, mit meist nur wenigen Einstellungsmöglichkeiten und oft fragwürdiger Qualität. Am anderen Ende des Spektrums liegt der professionelle Einsatz von Tablets im Grafikbereich, für den spezialisierte und entsprechend teure Geräte notwendig sind. Ich werde einige Apps aus dem Mittelfeld vorstellen, die sich für einfache wie anspruchsvolle Vorhaben und Projekte eignen, auch auf schwächeren Tablets laufen und preisgünstig oder gratis sind. Alle Apps bieten die Möglichkeit, unterwegs zu malen, zu skizzieren, Fotos zu verfremden und die entstandenen Bilder am PC weiter bearbeiten zu können. Für PCs gibt es einige empfehlenswerte kostenlose Malprogramme, die ich bereits in einem anderen Artikel (http://medienimpulse.at/articles/view/616 vorgestellt habe.

  7. A banalidade do mal e as possibilidades da educação moral: contribuições arendtianas

    Directory of Open Access Journals (Sweden)

    Marcelo Andrade

    2010-01-01

    Full Text Available Más que una época de crisis, enfrentamos hoy una crisis de época en la cual la educación desempeña un papel fundamental. En este sentido, el presente trabajo es una relectura de la obra de Hannah Arendt, filósofa que pensó y vivió en tiempos sombríos, con el fin de aclarar algunos conceptos que son fundamentales para que hoy pueda repensarse la educación moral o la educación en valores. A través de un estudio centrado en las obras Eichmann en Jerusalén: un estudio sobre la banalidad del mal y La vida del espíritu, este trabajo busca comprender cómo y por qué Hannah Arendt acuñó el concepto banalidad del mal y en qué sentido este se relaciona con el vacío del pensamiento y con una propuesta de educación en valores.

  8. Resposta clínico-parasitológica ao tratamento com quinino associado à doxiciclina em casos de malária falciparum não-complicada

    Directory of Open Access Journals (Sweden)

    Leal Osvaldo

    2003-01-01

    Full Text Available A resposta de portadores de malária falciparum, não-complicada, ao tratamento com quinino mais doxiciclina foi pesquisada em ensaio clínico aberto. A maioria dos portadores (76,2%; n=16 apresentaram plasmódios sensíveis e 23,8% (n=5 resistentes. Este esquema terapêutico parece ser ainda boa opção nos casos de malária falciparum não-complicada.

  9. Estudio observacional prospectivo con insulina detemir en pacientes con diabetes mellitus tipo 2 mal controlados que inician por primer vez tratamiento con insulina (estudio SOLVE)

    OpenAIRE

    Orozco-Beltrán, Domingo; Artola-Menéndez, Sara

    2016-01-01

    Objetivo: Describir la experiencia en atención primaria con insulina detemir en pacientes con diabetes mellitus tipo 2 mal controlados con antidiabéticos orales que necesitan incorporar una insulina a su terapia antidiabética. Métodos: Estudio observacional prospectivo de 6 meses de seguimiento realizado en 10 países. En España participaron solo centros de atención primaria. Se reclutaron pacientes con diabetes mellitus tipo 2 mal controlados a cuyo tratamiento con antidiabéticos orales se...

  10. Esquemas cognitivos e crenças mal-adaptativos da personalidade : elaboração de um instrumento de avaliação

    OpenAIRE

    Peres, Alexandre José de Souza

    2008-01-01

    A teoria cognitiva da psicopatologia postula que cada transtorno mental é caracterizado por um conjunto específico de esquemas mal-adaptativos. Este estudo levantou e testou a hipótese de que os esquemas idiossincráticos dos transtornos da personalidade também se distribuem em uma estrutura fatorial em amostras não-clínicas. Para tanto, foi construído um questionário de avaliação dos esquemas mal-adaptativos (QECP) teoricamente relacionados aos transtornos das personalidades dependente, obses...

  11. Mal, religión y saber: un enfoque relacional-integral que cuestiona diez paradigmas dominantes/Evil, Religion and Knowledge: a Relational-Integration Approach that Challenges Ten Dominant Paradigms

    National Research Council Canada - National Science Library

    Alberto J Gil Ibáñez

    2011-01-01

    ... disponibles, incluido un saber que aspira a relacionar e integrar diversos saberes en torno a un único objetivo: derrotar el mal o al menos intentarlo. Palabras clave: Mal, religión, saber, enfoque interdisciplinar. Evil, Religion and Knowledge: a Relational-Integration Approach that Challenges Ten Dominant Paradigms ABSTRACT The present social discourse a...

  12. Diet, nutritional status and food related traditions of Oraon tribes of New Mal (West Bengal), India.

    Science.gov (United States)

    Mittal, Poonam C; Srivastava, Sapna

    2006-01-01

    According to the 2001 census conducted by the Government of India, India has more than 84 million tribals who constitute 8.2% of India's population. The Oraons are an agricultural tribe found mainly in Orissa, Bihar, Jharkhand and West Bengal. The present study was undertaken on a group of Oraon tribals working in a tea gardens of New Mal in Jalpaiguri district of West Bengal. The children attended the local primary school. The Oraons are covered by the Integrated Child Development Scheme (ICDS) of the Government of India, which is concerned with the health, nutrition and development of children and their mothers. To evaluate the effect of ICDS, the practices of adults towards hygiene, medication, addictive substances and diet were also recorded. 500 Oraon tribals, including 200 men and 150 women aged 20-45 years, and 150 children aged 6-12 years, were surveyed for their dietary intake by 24-hour recall and semi-quantitative food frequency questionnaire methodology and anthropometry, and a description of food-related traditions. The diet of all Oraon groups was deficient in all food groups. Cereal intake was least deficient, while the intake of milk and fruit was almost negligible. Their diet was supplemented by a locally grown green leafy vegetable dheki saag, and fermented leftover rice. The energy available from the diet for all age groups was only 52-53% of the recommended dietary allowances of the Indian Council of Medical Research. Children were enrolled in a midday meal program at the local primary school; however, their energy intake was severely deficient, and of the same order as their parents. The mean basal mass index (BMI) of adult Oraons was not low, but children were severely undernourished. Men were less undernourished than were women. Some potentially useful traditions practiced included wiping washed utensils with leaves of a local plant mirchaiya, preparing herbal tablets called ranoodava to make an alcoholic and a medicinal drink called hadiya

  13. Mal tiempo, tiempo maligno, tiempo de subversión ritual. La temposensitividad agrofestiva invernal

    Directory of Open Access Journals (Sweden)

    Del Campo Tejedor, Alberto

    2006-06-01

    ícolas y expresivo (rituales y fiestas; y, finalmente, un tiempo bipolar, que se experimenta desde antiguo en dos estaciones —invierno y verano—, base de una temposensitividad agrofestiva igualmente dicotómica, que es analizada a raíz de la siguiente hipótesis: durante los meses de buen tiempo, especialmente mayo y junio, los rituales de nuestro entorno funcionan con un sentido propiciatorio y de exaltación positiva, escenificando miméticamente la unión entre tierra, vegetación, animal y hombre a través de prototipos o arquetipos que recrean simbólicamente el orden natural de las cosas. Por el contrario, las fiestas y rituales invernales —desde Todos los Santos hasta el Carnaval, y muy especialmente los días en torno a la Navidad— tienen en común su carácter grotesco y de inversión del orden, que expresa en clave simbólica, con una lógica jocoseria y ambigua, el lado oscuro de la existencia, conjurando ritualmente los miedos al mal tiempo, al tiempo aciago y nefasto, al tiempo del frío, la noche, el hambre y la muerte.

  14. Mal de Asclepio o Síndrome Judicial Médico

    Directory of Open Access Journals (Sweden)

    Hernán Urbina Joiro

    2015-12-01

    Full Text Available

    Se asocian crecientemente, de manera criminal, abogados, pacientes y médicos perversos contra médicos honestos, alineando el factor que peor puede degradar la medicina de hoy y potenciar sus otros males. Siendo dios de la medicina, el nacimiento y la muerte de Asclepio estuvieron marcados por la vileza, la que hoy amenaza de muerte a la profesión médica. Pero no hay que olvidar que finalmente Asclepio pudo ser resguardado de la perversidad.

    No se trata de la situación de quien denuncia legítimamente una transgresión cometida por un médico. El Mal de Asclepio o Síndrome Judicial Médico describe la actuación calculada por auténticos «enfermos» —en el sentido sociopático—, con manifiesta intención de ocasionar daño a médicos inocentes, comúnmente a través de prácticas delictivas, ocasionando además males permanentes en la salud física y mental de quienes se habían esforzado, irónicamente, para sanar a los demás, en esta era de degradación de la profesión médica, en este momento extraño donde el bastón de Asclepio, dios de la medicina, fue cambiado por el caduceo de Mercurio, dios del comercio y también de los ladrones (1.

    Asclepio fue un hijo no nacido, rescatado por un prodigio desde el vientre de su madre muerta y a punto de ser consumida por la pira funeraria. Coronis —o Corónide—, la madre, lo concibió tras un asalto del dios Apolo en la rivera de un río y, sin saber de su estado, cumplió con un pacto matrimonial arreglado por su padre, lo que incitó a Apolo a dar muerte a su joven esposo e impulsó a Artemisa, hermana de Apolo, a asesinar a flechazos a la propia Coronis. Fue el mismo Apolo quien, en el último momento, resolvió extraer del cadáver de Coronis al niño que puso por nombre Asclepio y que en adelante lucharía contra la muerte, incluso resucitando difuntos, hasta que la propia muerte —Hades— convenció de mala fe a Zeus, lo indujo al error —que más tarde

  15. Key economic sectors and services

    NARCIS (Netherlands)

    Arent, Douglas J.; Tol, Richard S.J.; Faust, Eberhard; Hella, Joseph P.; Kumar, Surender; Strzepek, Kenneth M.; Tóth, Ferenc L.; Yan, Denghua; Abdulla, Amjad; Kheshgi, Haroon; Xu, He; Ngeh, Julius

    2015-01-01

    Introduction and Context This chapter discusses the implications of climate change on key economic sectors and services, for example, economic activity. Other chapters discuss impacts from a physical, chemical, biological, or social perspective. Economic impacts cannot be isolated; therefore, there

  16. Third Sector and Social Media

    National Research Council Canada - National Science Library

    Ryan Deschamps; Kathleen McNutt

    2014-01-01

    ... operations. This is no less that case for organizations in the third sector. However, evidence-based practices tying social media activity to social media success are still elusive in the field...

  17. Trends in Public Sector Arbitration.

    Science.gov (United States)

    Graham, Harry; Wallace, Virginia

    1982-01-01

    Presents developments in grievance arbitration in government employment by examining all public sector arbitration cases from 1971 through 1979. Predicts that issues of employee discipline and discharge will comprise the largest number of cases proceeding to arbitration. (Author/MLF)

  18. Textile Manufacturing Sector (NAICS 313)

    Science.gov (United States)

    Find environmental regulatory and compliance information for the textile and leather manufacturing sector, including NESHAPs for leather tanning and fabric printing, and small business guidance for RCRA hazardous waste requirements.

  19. Wood and Paper Manufacturing Sectors

    Science.gov (United States)

    Find EPA regulatory information for the wood product and paper manufacturing sectors, including paper, pulp and lumber. Information includes NESHAPs and effluent guidelines for pulp and paper rulemaking, and compliance guidelines

  20. Controllership in de publieke sector

    NARCIS (Netherlands)

    Bossert, H.; Vosselman, E.G.J.

    2014-01-01

    De ontwikkeling van controllership in de publieke sector heeft sterk onder invloed gestaan van het discours over New Public Management. Afgrenzing van organisatorische eenheden, interne contractering, marktwerking en ‘accountability’ zijn essentiele elementen in dit discours. Toenemende complexiteit

  1. Cabo Verde - Private Sector Development

    Data.gov (United States)

    Millennium Challenge Corporation — The objective of the Private Sector Development Project activities of the 2005-2010 Cabo Verde Compact was to support Cabo Verde's long-term economic transformation...

  2. Security Sector Reform in Albania

    OpenAIRE

    Abazi, Enika; Bumci, Aldo; Hide, Enri; Rakipi, Albert

    2009-01-01

    International audience; This paper analyses security sector reform (SSR) in Albania. In all its enterprises in reforming the security sector,Albania is assisted by different initiatives and projects that provide expertise and financial support. To assesswhether reforms improved the overall security environment (national and human) of the country, it is necessaryto measure the effectiveness of the various initiatives and projects. This is gauged by how well the initiatives andprojects achieved...

  3. Decrease of the IgE-binding by Mal d 1, the major apple allergen, by means of polyphenol oxidase and peroxidase treatments

    NARCIS (Netherlands)

    Garcia-Borrego, A.; Wichers, J.H.; Wichers, H.J.

    2007-01-01

    Mal d 1, the major apple allergen, is heat labile and easily oxidized. Oxidative reactions catalyzed by polyphenol oxidase (PPO) and/or peroxidase (POD), present in apple, may be involved in decreasing its allergenicity. PPO and POD convert phenolic compounds into o-quinones. In this study the

  4. CADM1, MAL and miR124-2 methylation analysis in cervical scrapes to detect cervical and endometrial cancer

    NARCIS (Netherlands)

    De Strooper, Lise M. A.; van Zummeren, Marjolein; Steenbergen, Renske D. M.; Bleeker, Maaike C. G.; Hesselink, Albertus T.; Schuurs-Wisman, G. Bea A.; Snijders, Peter J. F.; Heideman, Danielle A. M.; Meijer, Chris J. L. M.

    2014-01-01

    Aims Gene promoter hypermethylation is recognised as an essential early step in carcinogenesis, indicating important application areas for DNA methylation analysis in early cancer detection. The current study was set out to assess the performance of CADM1, MAL and miR124-2 methylation analysis in

  5. le mal de pott sous occipital révélé par un abcès rétro pharyngien

    African Journals Online (AJOL)

    sation orthopédique ou chirurgicale de la charnière cervico-occipitale. Mots-clés : mal de Pott, tuberculose, rachis cervical, IRM, Bacille de Koch. SUMMARY. Introduction : Pott's disease is the most frequent localisation of osteo-articular tuberculosis. The suboccipital localisation remains rare. Case report : A 12-years old ...

  6. Mujer publicada mujer mal tratada. Libro de estilo para informar en los medios de comunicación sobre la mujer (Reseña)

    OpenAIRE

    Elías, C. (Carlos)

    2004-01-01

    Reseña del libro de José J. SÁNCHEZ ARANDA, Rosa BERGANZA CONDE y Carmela GARCÍA ORTEGA "Mujer publicada mujer mal tratada.Libro de estilo para informar en los medios de comunicación sobre la mujer" Gobierno de Navarra. Instituto Navarro de la Mujer, Pamplona, 2003, 190 pp.

  7. Short Summary European Reports on Retail Sector, Motor Vehicle Repair and Sales Sector, Food and Beverages Sector.

    Science.gov (United States)

    European Centre for the Development of Vocational Training, Berlin (Germany).

    This document is composed of European synthesis reports on retail trade, the agro-food sector, and the motor vehicle sales and repair sector. They are based on the most important findings of the European report and the 12 national reports for each sector. Section 1, "Retail Sector," deals in part 1 with the structure of retailing in the…

  8. Valuable insight into the anticancer activity of the platinum-histone deacetylase inhibitor conjugate, cis-[Pt(NH3)2malSAHA-2H)].

    Science.gov (United States)

    Brabec, Viktor; Griffith, Darren M; Kisova, Anna; Kostrhunova, Hana; Zerzankova, Lenka; Marmion, Celine J; Kasparkova, Jana

    2012-07-02

    cis-[Pt(II)(NH3)2(malSAHA-2H)], a cisplatin adduct conjugated to a potent histone deacetylase inhibitor (HDACi), suberoylanilide hydroxamic acid (SAHA), was previously developed as a potential anticancer agent. This Pt-HDACi conjugate was demonstrated to have comparable cytotoxicity to cisplatin against A2780 ovarian cancer cells but significantly reduced cytotoxicity against a representative normal cell line, NHDF. Thus, with a view to (i) understanding more deeply the effects that may play an important role in the biological (pharmacological) properties of this new conjugate against cancer cells and (ii) developing the next generation of Pt-HDACi conjugates, the cytotoxicity, DNA binding, cellular accumulation and HDAC inhibitory activity of cis-[Pt(II)(NH3)2(malSAHA-2H)] were investigated and are reported herein. cis-[Pt(II)(NH3)2(malSAHA-2H)] was found to have marginally lower cytotoxicity against a panel of cancer cell lines as compared to cisplatin and SAHA. cis-[Pt(II)(NH3)2(malSAHA-2H)] was also found to accumulate better in cancer cells but bind DNA less readily as compared to cisplatin. DNA binding experiments indicated that cis-[Pt(II)(NH3)2(malSAHA-2H)] bound DNA more effectively in cellulo as compared to in cell-free media. Activation of the Pt-HDACi conjugate was therefore investigated. The binding of cis-[Pt(II)(NH3)2(malSAHA-2H)] to DNA was found to be enhanced by the presence of thiol-containing molecules such as glutathione and thiourea, and activation occurred in cytosolic but not nuclear extract of human cancer cells. The activity of cis-[Pt(NH3)2(malSAHA-2H)] as a HDAC inhibitor was also examined; the conjugate exhibited no inhibition of HDAC activity in CH1 cells. In light of these results, novel Pt-HDACi conjugates are currently being developed, with particular emphasis, through subtle structural modifications, on enhancing the rate of DNA binding and enhancing HDAC inhibitory activity.

  9. Entre los caminos A y B elijo el incierto C: El bien, el mal y los dilemas éticos

    OpenAIRE

    Cláudio, Victor

    2009-01-01

    En este artículo partimos de las definiciones de Bien y de Mal que nos ofrece la filosofía para la interpretación de los dilemas éticos en la práctica de la Psicología. Subrayamos que, como referencia en el proceso de decisión subyacente a la resolución de los dilemas éticos, los psicólogos tienen además del Código Deontológico nacional, el Meta-Código de Ética europeo, sus principios morales, éticos y sus emociones. Se discuten algunos dilemas éticos que tienen lugar en la práctica ...

  10. Viveret Patrick, 2005, Pourquoi ça ne va pas plus mal?, Fayard, 264 p.

    Directory of Open Access Journals (Sweden)

    Fabien Thurette

    2008-05-01

    Full Text Available Patrick Viveret est philosophe de formation et Conseiller-maître à la Cour des comptes. Il a, en outre, été chargé d’une mission, confiée par l'éphémère Secrétaire d'État à l'économie solidaire Guy Hascoët, puis prolongée par le Président Chirac sur une « autre approche de la richesse », dont le rapport final a été publié sous le titre Reconsidérer la richesse (2004.Dans son essai Pourquoi ça ne va pas plus mal ? publié en 2005, Patrick Viveret nous livre une analyse philosophique sur le « m...

  11. The method of producing climate change datasets impacts the resulting policy guidance and chance of mal-adaptation

    Directory of Open Access Journals (Sweden)

    Marie Ekström

    2016-12-01

    Full Text Available Impact, adaptation and vulnerability (IAV research underpin strategies for adaptation to climate change and help to conceptualise what life may look like in decades to come. Research draws on information from global climate models (GCMs though typically post-processed into a secondary product with finer resolution through methods of downscaling. Through worked examples set in an Australian context we assess the influence of GCM sub-setting, geographic area sub-setting and downscaling method on the regional change signal. Examples demonstrate that choices impact on the final results differently depending on factors such as application needs, range of uncertainty of the projected variable, amplitude of natural variability, and size of study region. For heat extremes, the choice of emissions scenario is of prime importance, but for a given scenario the method of preparing data can affect the magnitude of the projection by a factor of two or more, strongly affecting the indicated adaptation decision. For catchment level runoff projections, the choice of emission scenario is less dominant. Rather the method of selecting and producing application-ready datasets is crucial as demonstrated by results with opposing sign of change, raising the real possibility of mal-adaptive decisions. This work illustrates the potential pitfalls of GCM sub-sampling or the use of a single downscaled product when conducting IAV research. Using the broad range of change from all available model sources, whilst making the application more complex, avoids the larger problem of over-confidence in climate projections and lessens the chance of mal-adaptation.

  12. Introduction of EDI in the public sector

    DEFF Research Database (Denmark)

    Falch, Morten

    1997-01-01

    Reviews the status of EDI in the sectors of health, public transport and taxation and public administration. The impact of this on the diffusion of EDI in other sectors is analysed.......Reviews the status of EDI in the sectors of health, public transport and taxation and public administration. The impact of this on the diffusion of EDI in other sectors is analysed....

  13. Monetary Policy with Sectoral Trade-offs

    DEFF Research Database (Denmark)

    Santoro, Emiliano; Petrella, Ivan; Rossi, Raffaele

    2017-01-01

    properties of simple rules that react to alternative measures of final goods price inflation. Due to factor demand linkages, the cost of production in one sector is influenced by price-setting in the other sector. Therefore, measures of aggregate inflation weighing sectoral prices based on their relative...... stickiness do not allow to keep track of the effective speeds of sectoral price adjustment....

  14. Economía del Sector Público

    OpenAIRE

    Jiménez García, Mercedes

    2012-01-01

    Tema1: Introducción al Sector Público. Tema 2: Actividad Económica y Sector Público. Tema3: La intervención del Sector Público y efectos económicos. Tema4: El Sector Público y el Estado del Bienestar. Tema 5: El presupuesto: los principios presupuestarios.

  15. Public Sector IS Maturity Models

    DEFF Research Database (Denmark)

    Zinner Henriksen, Helle; Andersen, Kim Normann; Medaglia, Rony

    2011-01-01

    Online applications and processing of tax forms, driver licenses, and construction permits are examples of where policy attention and research have been united in efforts aiming to categorize the maturity level of e-services. Less attention has been attributed to policy areas with continuous online...... citizenpublic interaction, such as in public education. In this paper we use a revised version of the Public Sector Process Rebuilding (PPR) maturity model for mapping 200 websites of public primary schools in Denmark. Findings reveal a much less favorable picture of the digitization of the Danish public sector...... compared to the high ranking it has received in the international benchmark studies. This paper aims at closing the gap between the predominant scope of maturity models and the frequency of citizen-public sector interaction, and calls for increased attention to the activities of government where the scale...

  16. Regulation of the power sector

    CERN Document Server

    2013-01-01

    Regulation of the Power Sector is a unified, consistent and comprehensive treatment of the theories and practicalities of regulation in modern power-supply systems. The need for generation to occur at the time of use occasioned by the impracticality of large-scale electricity storage coupled with constant and often unpredictable changes in demand make electricity-supply systems large, dynamic and complex and their regulation a daunting task. Conceptually arranged in four parts, this book addresses both traditional regulatory frameworks and also liberalized and re-regulated environments. First, an introduction gives a full characterization of power supply including engineering, economic and regulatory viewpoints. The second part presents the fundamentals of regulation and the third looks at the regulation of particular components of the power sector in detail. Advanced topics and subjects still open or subject to dispute form the content of the fourth part. In a sector where regulatory design is the key driver...

  17. Public Sector and Europeanization Challenges

    Directory of Open Access Journals (Sweden)

    Lucica Matei

    2006-04-01

    Full Text Available The paper emphasises the role of the market-type mechanisms within the activity of the organisations from the public sector. The end of the 20th century was defined by the effects of the public sector reform. The public sector is placed within the cultural and political environment of each country and the reforms have aimed to redefine the structures of the state organisations in the economy and the relationships such as market-government, government-bureaucracy, government- citizens, bureaucracy-citizens, civil servants-politicians-citizens. The public sector reform, achieved at the managerial systems, organisational structures and regulations levels is accompanied by specific and structural reforms. Accepting the market-type mechanisms instead of bureaucratic mechanisms, meaning not the simple provision of public services but the creation of some governmental “actors”, functioning completely on commercial bases, supporting the development of the partnerships between the public and private sector, introducing privatisation is achieved in view of creating “the facilitating state”. We discuss about “facilities” such as citizens and society involvement in public businesses, making public administration more citizen-friendly and the state closer to the public need. The citizens’ involvement, as customers in the flow of the public service contributes to creating an organic ensemble characterised by two fundamental dimensions: level and type of influence of the customers and the private-public dichotomy. Synthesising, the relationships and market mechanisms enable to the public sector to get closer to the public needs and to create a modern administration based on efficiency, effectiveness and openness towards change.

  18. Sectoral innovation foresight. Biotechnology sector. Final Reeport. Task 2

    NARCIS (Netherlands)

    Valk, T. van der; Gijsbers, G.W.; Meis, M.

    2010-01-01

    Biotechnology has evolved from a single set of technologies in the mid 1970s (e.g. recombinant DNA technology) into the full grown economic activity of today. The set of technologies that constitute the field of biotechnology thus find their applications in different sectors, most notably in

  19. Private Sector and Enterprise Development

    International Development Research Centre (IDRC) Digital Library (Canada)

    Lois organized a number of regional consultations on the private sector policy needs of MENA countries, led a project to carry out Global Entrepreneurship .... Conflict and political instability would have made it difficult for country visits to Iraq, Lebanon, Sudan and the West Bank & Gaza for safety and security reasons.

  20. IDRC on Private Sector Development

    International Development Research Centre (IDRC) Digital Library (Canada)

    Cathy Egan

    trade, and commerce as engines of economic growth. From its own practical support for private sector development, IDRC has learned that two kinds of assistance can pay dividends: improving the business environment, and stimulating innovation. If donor agencies work to enhance the general environment for business —.

  1. Aid and Sectoral Labour Productivity

    DEFF Research Database (Denmark)

    Selaya, Pablo; Thiele, Rainer

    2008-01-01

    The paper examines empirically the proposition that aid to poor countries is detrimental for external competitiveness, giving rise to Dutch disease type effects. At the aggregate level, aid is found to have a positive effect on growth of labour productivity. A sectoral decomposition shows...

  2. Sectoral profiles of working conditions

    NARCIS (Netherlands)

    Houtman, I.L.D.; Parent-Thirion, A.

    2003-01-01

    This report looks at trends in working conditions across different sectors over a five-year period 1995-2000. Basing its findings on the Third European Survey on Working Conditions carried out by the Foundation in 2000 in the 15 EU Member States and Norway, it examines the quality of working life in

  3. Communication in third sector organisations

    Directory of Open Access Journals (Sweden)

    Patricia Durán-Bravo, M.A.

    2010-01-01

    Full Text Available Third sector organisations favour the social development due to their capacity to produce human and social capital in society (Putman, 2001. In order to achieve social welfare third sector organisations need to produce a positive change in the relations among individuals, groups and institutions in a society. The expectations about the third sector organisations’ transparency and capacity to tackle social problems are increasing worldwide. In Mexico, this problematic is more complex because there is a low level of professionalism, transparency, accountability and participation culture in the organized civil society (ITAM, 2010. The development of the organized civil society in Mexico will depend to a great extent on its capacity to communicate its values to society and achieve a cultural and social change. Therefore, the third sector organisations must adopt strategic initiatives to reinforce their credibility and reputation, because the public and private donors are increasingly more demanding in their criteria to grant resources to social projects; and because the Mexican society has a low participation level and faces increasingly more complex social problems.

  4. Sustainability in the Agricultural sector

    Directory of Open Access Journals (Sweden)

    Anna Forgács

    2011-02-01

    Full Text Available The present study will examine the possible ways of integrating sustainability indicators in assessing the performance of agriculture. We are examining the appropriate ways of calculating the output of the sector including the damages caused by and the benefits of agricultural production. The involvment of environmental pressure into the assessment of agricultural performance does not show significant changes in values.

  5. O puru-puru da Amazônia (Pinta, Carate, Mal del Pinto etc

    Directory of Open Access Journals (Sweden)

    F. Nery Guimarães

    1948-03-01

    Full Text Available 1 "Purú-purú" é uma palavra indígena que quer dizer "pintado" ou "manchado", peculiar à Amazonia Brasileira. Com êsse nome é designada uma dermatose referida entre os selvicolas desde 1774, por Ribeiro Sampaio. Certas tribus, com alta incidência da moléstia passaram a ser cahamadas também "Purú-purús", o mesmo acontecendo com o rio onde habitavam - Rio Purús. 2 A doença existe na bacia do Rio Solimões e seus principais afluentes: Javari, Juruá, Purús, Içá, Japurá, e Negro. Por esses rios, o fóco da dermatose se continua nos países limitrofes com o Brasil: Guianas, Venezuela, Colombia, Perú (Equador e Bolivia. 3 Desde 1890 essa dermatose foi relacionada à pinta (carate ou mal del pinto por P. S. de Magalhães, idéa essa depois defendida por Juliano Moreira, Carlos Chagas, Roquete Pinto, Wappeus, O. da Fonseca Filho, Da Matta, Brumpt e outros, baseados na semelhança clínica e na terapêutica. Recentemente (1945, essa provavel identidade das duas dermatoses, recebeu fundamento sorológico de Biocca (que verificou a positividade das reações de Kline e Kahn em doentes de purú-purú, e, pelo presente trabalho, recebe base clínico-epidemio-anatomo-patológica. 4 Sob o ponto de vista clínico, as lesões cutaneas discromicas da moléstia, são de 3 órdens: a lesões papulo-eritemato-escamosas, isoladas ou não, arredondadas, pruriginosas e de bordos nitidos; b lesões maculo-escamosas, maiores mais pálidas, ás vezes já mostrando alterações pigmentares na parte central; c máculas discromod´rmicas, lisas ou ligeiramente escamosas, com maior ou menor alteração pigmentar, as quais assumem diferentes aspéctos, consequentes à hipo - ou hiperpigmentação, variaveis também com a côr do paciente. As colorações predominantes nas manchas, são o branco, o preto e o vermelho, com tonalidades eminentemente variaveis. Embora raramente, nessas extensas dermodiscromias, observa-se superposição de lesões papulo

  6. Sectoral Innovation Watch Retail and Wholesale Trade Sector. Final sector report

    NARCIS (Netherlands)

    Schaffers, H.; Rubalcaba, L.; Merino, F.; Giesecke, S.; Schaper-Rinkel, P.; Velsing, E.J.; Montalvo, C.

    2011-01-01

    The retail and wholesale trade sector traditionally is considered as a poor innovator. Innovation is seen as driven mostly by applications of information and communication technology (ICT). This report adopts a more comprehensive definition of innovation than the traditional one, taking into account

  7. Crecimiento y desarrollo del sector asegurador; frente a la evolución cultural de las empresas de familia

    Directory of Open Access Journals (Sweden)

    Juan Hernando Bravo Reyes

    2016-04-01

    Full Text Available El tema de los seguros se convirtió en una necesidad, al igual que el conocimiento de una segunda lengua. El mundo de los negocios exige que el conocimiento en seguros sea indispensable es por esta razón que en es te documento se analiza el crecimiento y desarrollo del sector asegurador frente a las necedades de las empresas de familia pequeñas y medianas, lomando como punto de partida la historia y perspectivas futuras ele más de 125 años, que en su momento, forjaron las primeras compañías colombianas ele seg uros. Se es tudian las implicaciones del sector asegurador en la evolución cultural ele es te tipo ele empresas, determinando algunas de las razones que han generado des confianza entre aseguradoras y asegurados, se evalúan las exigencias y garantías al momento de contratar una póliza ele seguro, así como los documentos y requisitos para reclamar en caso de un siniestro para concluir que en materia de seguros el modelo cultural de los colombianos se mantiene estancado, la desconfianza y mal entendimiento entre los contratantes es el común denominador de un negocio que tiene como principio fundamental la buena fe; entonces ¿cuál será el futuro del sector bajo este panorama?

  8. Tratamento de 75 pacientes portadores de malária pelo P. falciparum, em Porto Velho (RO, com mefloquina

    Directory of Open Access Journals (Sweden)

    João Barberino Santos

    1988-12-01

    Full Text Available Foi avaliada a resposta terapêutica em 75 doentes com malária pelo P. falciparum, em Porto Velho - Rondônia, tratados com mefloquina nas doses de 1250, 1000 e 750 mg. Não houve diferença significante nos resultados obtidos nos três grupos. Até o terceiro dia de tratamento, a febre desapareceu em 76,0% dos casos. A parasitemia negativou-se em 68,0% dos pacientes nos 3 primeiros dias após o inicio do tratamento, em 24,0% no quarto dia e em 5,3% no quinto.Havia um doente positivo no sexto dia e outro no sétimo. Nenhum paciente apresentou trofozoito no período de seguimento de 7 a 28 dias. Não houve modificações do quadro hematológico, exceto por um incremento da taxa de reticulócitos em 76,0%. As alterações bioquímicas registradas no seguimento dos doentes constaram de elevação da desidrogenase lática (28,0% e, dafosfatase alcalina (41,3%. As reações colaterais foram discretas e infreqüentes; em 72,0% dos tratados não se constatou nenhum efeito secundário. Não se verificou nenhum caso de recidiva. A mefloquina revelou-se eficaz e bem tolerada no tratamento da malária no Estado de Rondônia.Mefloquine was evaluated for the treatment of falciparum malaria in 75 patients in Porto Velho, Rondonia. Each patient was randomly assigned to one of three treatment groups and treated under a double blind protocol with a total dose of750,1000 or 1250 mg of mefloquine per person. There were no significant differences among the groups. By the thirdy day of treatment 76% of the patients were without fever and 68% were without parasites. The hemograms were normal except for an increase in the number of reticulocytes in 76% of the patients. The concentration of lactic dehydrogenase in serum was elevated in 28% of the patients and the concentration of alkaline phosphatase was elevated in 41 %. Mild side effects were encountered in 18% of the patients. None of the patients suffered a relapse of malaria. It is concluded that mefloquine is

  9. Rozvoj malého a stredného podnikania v Slovenskej republike

    Directory of Open Access Journals (Sweden)

    Irina Bondareva

    2013-11-01

    Full Text Available Purpose of the article: Slovakia's accession to the EU caused an increased role for small and medium entrepreneurship in the economy and simultaneously increased the requirements for this sector of the economy in view of the high competition in the European market. At the same time small and medium-sized enterprises SR face major difficulties which adversely affect their development. In this context, it is necessary to continuously monitor the business environment for the purpose of removing obstacles to business. Methodology/methods: The method of research is time series analysis of small and medium-sized enterprises SR, analysis of the structure of economic activity, synthesis of information provided by various institutions dealing with the rating business. Scientific aim: The article is to examine trends in the development of small and medium enterprises in Slovakia during the year 2004 - 2009 and evaluate the current business environment of the SR. Findings: The analysis shows that the number of small and medium-sized enterprises in the years 2004-2009 in Slovakia has an increasing trend. During this period, major barriers have been removed in the normative and legal acts, particularly the creation of new firms, has made tax reform introduced a flat tax on income, to adopt transparent rules on state aid to investors. Positive impact on the development of small and medium-sized enterprises have so stable macroeconomic and political situation in Slovakia. Conclusions (limits, implications etc However, there remains a considerable number of factors that complicate their development. In particular, it is a poor law enforcement, inadequate capacity, quality and availability of credit information for efficient and safe lending, which has restricted access to bank loans, lack of qualified entrepreneurs, large scale and long term to meet the established administrative procedures, high tax and contribution burden , fee burden on

  10. Cabeza vestida de noche: imaginario del mal y de capitación en “Fiesta en la madriguera” de Juan Pablo Villalobos

    Directory of Open Access Journals (Sweden)

    Orfa Kelita Vanegas

    2016-01-01

    Full Text Available Este estudio se centra en el simbolismo de la decapitación en Fiesta en lamadriguera de Juan PabloVillalobos. Ficción que ingenia un lenguaje para significar la decapitación del cuerpo humano como expresión radical de la voluntad maligna. Y, aunque es la figuración de la violencia extrema la que aparece de nuevo, capta la atención la novedaddel enfoque narrativo,que, desde una perspectiva infantil, significa unimaginario “narco” del mal. La decapitación representada como imagen operativa del mal, da qué pensar sobre la naturaleza inteligible del ser humano, a la vez que funda un espacio de contestaciones contra las políticas de la abyección, que se ubican en el corazón mismo del sujeto, la sociedad y el Estado.

  11. AVALIAÇÃO DA ARBORIZAÇÃO URBANA PELOS RESIDENTES - ESTUDO DE CASO EM MAL. CÂNDIDO RONDON, PARANÁ

    OpenAIRE

    Ubirajara Contro Malavasi; Marlene de Matos Malavasi

    2001-01-01

    Este estudo objetivou quantificar a percepção da arborização urbana da cidade de Mal. Cândido Rondon, Paraná, pelos munícipes residentes. Os dados foram obtidos por meio da aplicação de um questionário a trinta residentes localizados em 53 pontos de amostragem da área urbana do município perfazendo um total de 1.590 entrevistas. Os resultados indicaram que, para 56% da população urbana, a cidade de Mal. Cândido Rondon, assim como a rua de residência do munícipe possuem alguma arborização. ...

  12. Interest Organizations across Economic Sectors

    DEFF Research Database (Denmark)

    Berkhout, Joost; Carroll, Brendan; Braun, Caelesta

    2015-01-01

    on the basis of political and economic institutional factors. Focusing on business interest representation, we show that economic institutions structure the ‘supply’ of interest organizations by affecting the number of potential constituents, the resources available for lobbying and the geographical level......The number of interest organizations (density) varies across policy domains, political issues and economic sectors. This shapes the nature and outcomes of interest representation. In this contribution, we explain the density of interest organizations per economic sector in the European Union...... of collective action of businesses. In contrast, we do not find consistent evidence that political institutions produce ‘demand’ for interest organizations by making laws, developing public policy or spending money. This is in contrast to the extensive evidence that such factors affect lobbying practices...

  13. Public Sector and Europeanization Challenges

    Directory of Open Access Journals (Sweden)

    Lucica Matei

    2006-02-01

    Accepting the market-type mechanisms instead of bureaucratic mechanisms, meaning not the simple provision of public services but the creation of some governmental “actors”, functioning completely on commercial bases, supporting the development of the partnerships between the public and private sector, introducing privatisation is achieved in view of creating “the facilitating state”. We discuss about “facilities” such as citizens and society involvement in public businesses, making public administration more citizen-friendly and the state closer to the public need. The citizens’ involvement, as customers in the flow of the public service contributes to creating an organic ensemble characterised by two fundamental dimensions: level and type of influence of the customers and the private-public dichotomy. Synthesising, the relationships and market mechanisms enable to the public sector to get closer to the public needs and to create a modern administration based on efficiency, effectiveness and openness towards change.

  14. sector turístico

    Directory of Open Access Journals (Sweden)

    Adelaida Lillo Bañuls

    2007-01-01

    Full Text Available Los importantes cambios acaecidos en los últimos años, han modificado el panorama del mercado turístico mundial y le han enfrentado a nuevos retos y oportunidades. Ello ha supuesto la necesidad de estudiar qué nuevos factores y estrategias garantizan la competitividad de las empresas del sector. Entre otros, es sin duda indispensable analizar el papel clave del capital humano turístico como estrategia competitiva en un nuevo contexto internacional. En este trabajo se estudia la importancia creciente del factor humano en los servicios turísticos, como elemento básico y diferenciador, capaz de aportar ventajas competitivas, destacando la importancia del valor de los intangibles en este sector. Asimismo, se analiza el papel clave de la educación y formación turísticas en el desarrollo de estrategias de competitividad en las actividades vinculadas al turismo.

  15. Sectoral composition and macroeconomic dynamics

    OpenAIRE

    Alonso Carrera, Jaime

    2011-01-01

    We analyze the transitional dynamics of a model with heterogeneous consumption goods. In this model, convergence is driven by two different forces: the typical diminishing returns to capital and the sectoral change inducing the variation in relative prices. We show that this second force affects the growth rate if the two consumption goods are not Edgeworth independent and if these two goods are produced with technologies exhibiting different capital intensities. Because the afore mentioned d...

  16. Malaysia; Financial Sector Stability Assessment

    OpenAIRE

    International Monetary Fund

    2013-01-01

    This assessment is a review of the financial environment of Malaysia. Like many other Asian countries, Malaysia experienced financial distress in the late 1990s, but the country’s policy reforms have moved it to a successful economy. A ten-year financial plan (2001–10) by Bank Negara Malaysia restructured the financial sector. Banks were well capitalized, household debts were strengthened, and securities and insurances were developed. Malaysia thus became the global center for Islamic finance...

  17. Efeito de ação educativa participativa no conhecimento de professores do ensino básico sobre malária

    Directory of Open Access Journals (Sweden)

    Martha Cecilia Suárez-Mutis

    2011-10-01

    Full Text Available OBJETIVO: Descrever uma estratégia educativa participativa de construção de conhecimentos relacionados à malária entre professores em um município altamente endêmico. MÉTODOS: Foi feito um estudo observacional. Um curso de 40 horas foi realizado sob enfoque multidisciplinar e problematizador para 46 professores, prioritariamente da área rural, no município de Barcelos, AM, em 2008. O processo educativo participativo incluiu oficinas e aulas práticas. Para investigar os conhecimentos, aplicou-se um questionário previamente validado, antes e após o curso, avaliado por abordagens quantitativa e qualitativa usando a análise temática para respostas abertas. RESULTADOS: Previamente ao curso, os professores tinham pouca informação sobre os mecanismos de transmissão, meios de prevenção e a associação da malária aos seus vetores, bem como conceitos restritos sobre saúde. Após o curso, não somente aumentou o conhecimento dos professores sobre a malária como também emergiram reflexões sobre o papel do professor na sociedade. CONCLUSÕES: O efeito da ação educativa na construção de um saber contextualizado sobre malária e saúde indica o potencial da estratégia desenvolvida. Processos de educação permanente são necessários à sustentabilidade dos novos saberes e práticas, orientados pela promoção da saúde.

  18. Avaliação de genótipos tetraploides de bananeira cultivados em área infestada pelo agente causal do mal-do-Panamá

    Directory of Open Access Journals (Sweden)

    Sebastião de Oliveira e Silva

    2011-03-01

    Full Text Available O mal-do-Panamá é uma doença que causa grandes prejuízos à bananicultura no Brasil, uma vez que as principais cultivares em uso são suscetíveis ao Fusarium. Este trabalho teve como objetivos avaliar características agronômicas e resistência ao mal-do-Panamá de híbridos tetraploides de bananeira. O experimento foi conduzido no campo experimental da Embrapa Mandioca e Fruticultura Tropical, em delineamento casualizado, com 14 tratamentos e 10 repetições, nos anos de 2000 e 2001. Foram avaliados 14 tetraploides (FHIA-03, PV03-44, PC42-01, PV42-53, PV42-68, PV42-81, PV42-85, PV42-129, PV42-142, PV42-143, SH3640, ST12-31, ST42-08 e YB42-21 e a cultivar Maçã, usada como testemunha. Avaliaram-se as características altura da planta (m e diâmetro do pseudocaule (cm a 30 cm do solo, peso da massa do cacho (kg, penca (kg e fruto (g, número de pencas por cacho, de frutos por penca e de dias do florescimento à colheita, e a incidência do mal-do-Panamá. As médias dos genótipos foram agrupadas pelo teste de Scott e Knott, a 5% de probabilidade. Observa-se uma ampla variação genética nos caracteres avaliados. Os genótipos FHIA 03, ST12-31, SH3640, PV42-142, PV42-53 e PV42-68apresentam boas características agronômicas e resistência ao mal-do-Panamá.

  19. La normalidad como excepción: la banalidad del mal, la conciencia y el juicio en la obra de Hannah Arendt

    OpenAIRE

    Marco Estrada Saavedra

    2007-01-01

    En este artículo, el autor expone la relevancia de las cuestiones morales en la obra de Hannah Arendt. Con este fin, se establece el significado de la fórmula "la banalidad del mal" para explicar las complejas conexiones entre el pensamiento, la conciencia y el juicio y cómo este circuito es destruido en el totalitarismo mediante la ideología, el terror y el aniquilamiento de la política.

  20. Macroscopic Theory of Dark Sector

    Directory of Open Access Journals (Sweden)

    Boris E. Meierovich

    2014-01-01

    Full Text Available A simple Lagrangian with squared covariant divergence of a vector field as a kinetic term turned out to be an adequate tool for macroscopic description of the dark sector. The zero-mass field acts as the dark energy. Its energy-momentum tensor is a simple additive to the cosmological constant. Massive fields describe two different forms of dark matter. The space-like massive vector field is attractive. It is responsible for the observed plateau in galaxy rotation curves. The time-like massive field displays repulsive elasticity. In balance with dark energy and ordinary matter it provides a four-parametric diversity of regular solutions of the Einstein equations describing different possible cosmological and oscillating nonsingular scenarios of evolution of the Universe. In particular, the singular big bang turns into a regular inflation-like transition from contraction to expansion with the accelerated expansion at late times. The fine-tuned Friedman-Robertson-Walker singular solution is a particular limiting case at the lower boundary of existence of regular oscillating solutions in the absence of vector fields. The simplicity of the general covariant expression for the energy-momentum tensor allows displaying the main properties of the dark sector analytically. Although the physical nature of dark sector is still unknown, the macroscopic theory can help analyze the role of dark matter in astrophysical phenomena without resorting to artificial model assumptions.

  1. Informal sector on labour market

    Directory of Open Access Journals (Sweden)

    Silvia PISICĂ

    2011-06-01

    Full Text Available The informal sector is omnipresent, existing in the market economies and centrally planned economies in both the developing and developed ones. The sector achieved results that run the economy and engage workers who work, earn income and consume. Knowledge of this segment and its measurement is of particular importance in terms of economic science. This requires first drawing a conceptual framework that provides a historical approach and theoretical point of view of the economy and informal employment, and a discussion on the latest concepts designed to capture the “informality” in the economy.Two concepts were adopted: the employment in informal sector and the informal employment - that complement each other (Concepts adopted by the International Conferences of Labour Statisticians in 1993 and 2003. According to first concept the definitions was done in terms of characteristics of the production units in which the activities take place, while according to the second concept, in terms of the characteristics of the persons involved or of their jobs.

  2. Transglycosylation properties of maltodextrin glucosidase (MalZ) from Escherichia coli and its application for synthesis of a nigerose-containing oligosaccharide

    Energy Technology Data Exchange (ETDEWEB)

    Song, Kyung-Mo [Center for Agricultural Biomaterials and Department of Food Science and Biotechnology, Seoul National University, Seoul 151-921 (Korea, Republic of); Shim, Jae-Hoon [Department of Biology, University of Incheon, Incheon 406-772 (Korea, Republic of); Park, Jong-Tae; Kim, Sung-Hee [Center for Agricultural Biomaterials and Department of Food Science and Biotechnology, Seoul National University, Seoul 151-921 (Korea, Republic of); Kim, Young-Wan [Department of Food and Biotechnology, Korea University, Jochiwon 339-700 (Korea, Republic of); Boos, Winfried [Department of Biology, University of Konstanz, Konstanz 78457 (Germany); Park, Kwan-Hwa, E-mail: parkkh@incheon.ac.kr [Department of Biology, University of Incheon, Incheon 406-772 (Korea, Republic of)

    2010-06-18

    The transglycosylation reaction of maltodextrin glucosidase (MalZ) cloned and purified from Escherichia coli K12 was characterized and applied to the synthesis of branched oligosaccharides. Purified MalZ preferentially catalyzed the hydrolysis of maltodextrin, {gamma}-cyclodextrin (CD), and cycloamylose (CA). In addition, when the enzyme was incubated with 5% maltotriose (G3), a series of transfer products were produced. The resulting major transfer products, annotated as T1, T2, and T3, were purified and their structures were determined by TLC, MALDI-TOF/MS, {sup 13}C NMR, and enzymatic analysis. T1 was identified as a novel compound, maltosyl {alpha}-1,3-maltose, whereas T2 and T3 were determined to be isopanose and maltosyl-{alpha}-1,6-maltose, respectively. These results indicated that MalZ transferred sugar moiety mainly to C-3 or C-6-OH of glucose of the acceptor molecule. To obtain highly concentrated transfer products, the enzyme was reacted with 10% liquefied cornstarch, and then glucose and maltose were removed by immobilized yeast. The T1 content of the resulting reaction mixture reached 9.0%. The mixture of T1 containing a nigerose moiety can have an immunopotentiating effect on the human body and may be a potential functional sugar stuff.

  3. Epigeic spiders (Araneae from the Malá Dohoda Quarry (Moravian Karst Protected Landscape Area, Czech Republic

    Directory of Open Access Journals (Sweden)

    Ondřej Košulič

    2013-01-01

    Full Text Available This publication makes a faunistic contribution to knowledge of the epigeic spider species composition in the limestone quarry Malá Dohoda which is located in Moravian Karst PLA. The spiders were collected by pitfall trapping between catching period 19. 3.–1. 11. 2012. We chose 6 plots all around the quarry – in the inner part, edges of quarry and outside part of quarry. A total of 1 474 adult specimens were collected and determined as 78 species of 21 families. The most significant finding is vulnerable species (VU Parapelecopsis nemoralis (Blackwall, 1841 which is the second record for Moravia. Among the other significant findings, both in term of rarity and bioindication, were Ceratinella major Kulczynski, 1894, Micaria formicaria (Sundevall, 1831, Ozyptila claveata (Walckenaer, 1837, Pelecopsis parallela (Wider, 1834, Zelotes longipes (L. Koch, 1866 and Zodarion rubidum Simon, 1914. Also, we present finding of an invasive species Mermessus trilobatus (Emerton, 1882 which is spreading in the Czech Republic since 2007. Together, we found 13 species as a novelty for studied faunistic square 6666 and we extended knowledge about new recorded species for the area of the Moravian Karst.

  4. Genetic threshold hypothesis of neocortical spike-and-wave discharges in the rat: An animal model of petit mal epilepsy

    Energy Technology Data Exchange (ETDEWEB)

    Vadasz, C.; Fleischer, A. [Nathan Kline Inst. for Psychiatric Research, Orangeburg, NY (United States); Carpi, D.; Jando, G. [State Univ. of New Jersey, Newark, NJ (United States)] [and others

    1995-02-27

    Neocortical high-voltage spike-and-wave discharges (HVS) in the rat are an animal model of petit mal epilepsy. Genetic analysis of total duration of HVS (s/12 hr) in reciprocal F1 and F2 hybrids of F344 and BN rats indicated that the phenotypic variability of HVS cannot be explained by simple, monogenic Mendelian model. Biometrical analysis suggested the presence of additive, dominance, and sex-linked-epistatic effects, buffering maternal influence, and heterosis. High correlation was observed between average duration (s/episode) and frequency of occurrence of spike-and-wave episodes (n/12 hr) in parental and segregating generations, indicating that common genes affect both duration and frequency of the spike-and-wave pattern. We propose that both genetic and developmental - environmental factors control an underlying quantitative variable, which, above a certain threshold level, precipitates HVS discharges. These findings, together with the recent availability of rat DNA markers for total genome mapping, pave the way to the identification of genes that control the susceptibility of the brain to spike-and-wave discharges. 67 refs., 3 figs., 5 tabs.

  5. A democracia no Brasil não é um mal-entendido = Democracy in Brazil is not a misunderstanding

    Directory of Open Access Journals (Sweden)

    Coelho, Maria Francisca Pinheiro

    2014-01-01

    Full Text Available A ideia deste trabalho surgiu da famosa frase de Sérgio Buarque de Holanda, em Raízes do Brasil: “A democracia no Brasil foi sempre um lamentável mal-entendido. ” Para o autor, inspirado nos tipos ideais weberianos e sob um olhar comparativo, o Brasil com seu homem cordial – aquele que age mais pelo coração do que pela razão – e com o predomínio do espaço privado sobre o público não se apresentava como um solo receptivo aos valores de igualdade da democracia. O texto pretende sugerir que a institucionalização das regras do jogo democrático relativiza o peso da cultura, sem, contudo, alterar seus traços no ritmo compatível com as mudanças das normas. O Brasil, com todos os problemas decorrentes de uma sociedade desigual e hierárquica, situa-se atualmente entre as democracias mais consolidadas da América Latina, que mais interagem e que apresentam disposição para o diálogo

  6. Exchange field effect in the crystal field ground state of CeMAl{sub 4}Si{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Kai; Strigari, Fabio; Sundermann, Martin; Severing, Andrea [University of Cologne, Cologne (Germany); Agrestini, Stefano [Max Planck Institute for Chemical Physics of Solids, Dresden (Germany); Bauer, Eric D.; Sarrao, John L.; Thompson, Joe D. [Los Alamos National Laboratory, Los Alamos, NM (United States); Otero, Edwige [Synchrotron Soleil, Gif-sur-Yvette (France); Tanaka, Arata [Hiroshima University, Higashi-Hiroshima (Japan)

    2016-07-01

    The crystal-field ground state wave functions of the tetragonal Kondo lattice materials CeMAl{sub 4}Si{sub 2}(M = Rh, Ir and Pt), as well as the crystal-field splittings, are determined with low temperature linear polarized soft x-ray absorption spectroscopy. Surprisingly, at T < 20 K, which is far below the first excited crystal-field level at 200 K, a change in linear dichroism was observed that cannot be accounted for by population of crystal-field states. Adding an exchange field to the ionic full multiplet calculations below 20 K leads to a splitting to the ground state doublet and modification of J{sub z} admixture, thus accounting for the change in low temperature linear dichroism. The direction of the required exchange field is parallel along c-axis for the antiferromagnetic Rh and Ir compounds, and perpendicular to c-axis for ferromagnetic CePtAl{sub 4}Si{sub 2}.

  7. Malária no Brasil: panorama epidemiológico na última década

    Directory of Open Access Journals (Sweden)

    Barata Rita de Cássia B.

    1995-01-01

    Full Text Available Este artigo apresenta, de maneira resumida, as principais alterações que marcaram a ocorrência de malária, no Brasil, nesta última década. Chama-se a atenção para o processo de focalização da doença, com a concentração da transmissão em áreas, relativamente restritas, da região amazônica. A mudança na situação epidemiológica acarreta a revisãoconceitual, levando ao abandono da concepção de "doença de massa" e à elaboração da teoria focal. Do mesmo modo, as ações de controle sofrem os impactos das transformações ocorridas e as tentativas de erradicação são abandonadas e substituídas por medidas de controle diversificadas e adaptadas a cada localidade. As novas propostas, oriundas da Conferência Ministerial de Amsterdam, são apresentadas e comentadas.

  8. Surto de malária por Haemoproteus columbae em pombos An outbreak of malaria by Haemoproteus columbae in pigeons

    Directory of Open Access Journals (Sweden)

    J.S. Resende

    2001-06-01

    Full Text Available Relata-se um surto de malária por Haemoproteus columbae em pombos-correio (Columba livia, caracterizado por um quadro agudo com mortalidade de 3% ao dia em aves de aspecto saudável ou crônico com prostração e fraqueza. O exame clínico das aves doentes evidenciou sinusite e conjuntivite e à necropsia traqueíte hemorrágica, aerossaculite, esplenomegalia, nefromegalia e hepatomegalia com hemorragias. O díptero hematófago da família Hippoboscidae Pseudolynchia canariensis foi encontrado inserido entre as penas dos indivíduos. Esfregaços de sangue periférico e cardíaco e impressões de baço e fígado corados por Giemsa permitiram a visualização de inclusões intraeritrocitárias características de Haemoproteus columbae

  9. The utilization of a non-invasive fluorescence imaging system to follow clinical dermatological MAL-PDT

    Science.gov (United States)

    Tyrrell, Jessica; Campbell, Sandra; Curnow, Alison

    2009-06-01

    This study employed a commercially available, non-invasive, fluorescence imaging system (Dyaderm, Biocam, Germany), to measure protoporphyrin IX (PpIX) concentration at several different stages during clinical dermatological methyl aminolevulinate photodynamic therapy (MAL-PDT). We validated the system prior to use to ensure that the PpIX changes witnessed were accurate and not due to environmental or user induced artifacts. The system was then employed to acquire color (morphological) and fluorescent (physiological) images simultaneously during dermatological PDT. Clinical data was collected from a range of licensed dermatological conditions (actinic keratosis, Bowen's disease and superficial basal cell carcinoma) during initial and subsequent PDT treatment cycles. The initial clinical data indicated that each type of licensed lesion considered responded in a similar manner following the application of Metvix (Galderma, U.K.) and the subsequent light irradiation (Aktilite, Galderma, U.K.). Images acquired three hours after Metvix application showed a significant increase in PpIX concentration within the lesion (P treatment cycles accumulated significantly less PpIX (P < 0.05) prior to irradiation.

  10. The increased importance of sector switching

    DEFF Research Database (Denmark)

    Frederiksen, Anders; Hansen, Jesper Rosenberg

    2017-01-01

    Sector switching is an important phenomenon that casts light on public–private differences. Yet our knowledge about its prevalence and trends is limited. We study sector switching using unique Danish register-based employer–employee data covering more than 25 years. We find that sector switching...

  11. Lessons Learned from the Private Sector

    Energy Technology Data Exchange (ETDEWEB)

    Robichaud, Robert J [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-09-07

    This session is focused on lessons learned from private sector energy projects that could be applied to the federal sector. This presentation tees up the subsequent presentations by outlining the differences between private and federal sectors in objectives, metrics for determining success, funding resources/mechanisms, payback and ROI evaluation, risk tolerance/aversion, new technology adoption perspectives, and contracting mechanisms.

  12. Pricing in the hotel and catering sector

    NARCIS (Netherlands)

    W.H.M. van der Hoeven; A.R. Thurik (Roy)

    1987-01-01

    textabstractA model explaining gross margins in the hotel and catering sector is developed. A cost-mark-up model for the retail sector is used as a starting point. Although we have to reject the hypothesis of mark-up pricing in the hotel and catering sector, the model proves a useful instrument to

  13. Sectoral approaches to improve regional carbon budgets

    NARCIS (Netherlands)

    Smith, P.; Nabuurs, G.J.; Janssens, I.A.; Reis, S.; Marland, G.; Soussana, J.F.; Christensen, T.R.; Heath, L.; Apps, M.; Alexeyev, V.; Fang, J.; Gattuso, J.P.; Guerschman, J.P.; Huang, Y.; Jobbagy, E.; Murdiyarso, D.; Ni, J.; Nobre, A.; Peng, C.; Walcroft, A.; Wang, S.Q.; Pan, Y.; Zhou, G.S.

    2008-01-01

    Humans utilise about 40% of the earth¿s net primary production (NPP) but the products of this NPP are often managed by different sectors, with timber and forest products managed by the forestry sector and food and fibre products from croplands and grasslands managed by the agricultural sector. Other

  14. Leading sector development in Muaro Jambi District

    Directory of Open Access Journals (Sweden)

    Muhammad Safri

    2017-09-01

    Full Text Available Efforts to improve economic development and economic growth of Muaro Jambi Regency is a must. Efforts to increase economic development and economic growth can occur, if local governments are able to determine or identify priority sectors or become a base sector. Given the importance of determining and defining the right and correct strategy in the development of leading economic sectors/bases, it is necessary to conduct further study related to the development of leading sector policy in Muaro Jambi Regency. Analysis tools that are used are LQ (Location Quotient and SWOT analysis. The results of the analysis found that of there are three sectors that are the main sector or base in Muaro Jambi Regency, namely agriculture, livestock, plantation, fishery and forestry sector, mining and quarrying sector and manufacturing industry sector. Strategies that can be done in order to maintain and develop the sector and sub-sectors/recommended base there are several alternative strategies that combine internal environmental conditions and external environment Muaro Jambi Regency is S - O (power against opportunities, S - T (power against threats W - O (weakness to opportunity and W - T (weakness to threat. Keywords: Location Quotient, SWOT Analysis, Base Sector

  15. Sectoral Innovation Performance in the Space and Aeronautics Sectors. final report. Task 1

    NARCIS (Netherlands)

    Giessen, A.M. van der; Poel, M.

    2011-01-01

    The Space and Aeronautics Sectors are high tech manufacturing sectors. Between Space and Aeronautics Sectors are linkages and parallels. All major systems assemblers are active in both sectors. Examples are EADS but also Boeing, BAE Systems and manufacturers of propulsion systems and other

  16. Malária grave secundária a co-infecção por Plasmodium falciparum e Plasmodium ovale

    Directory of Open Access Journals (Sweden)

    Eduardo Ribeiro

    2013-03-01

    Full Text Available A malária é causada pela infeção por protozoários do género Plasmodium, sendo uma importante causa de doença, especialmente em países tropicais. O diagnóstico de malária é baseado na suspeita clínica e na deteção dos parasitas no sangue. O P. falciparum é a espécie que causa maior morbilidade e mortalidade. O efeito da co-infeção por múltiplas espécies sobre a evolução clínica não é certo. Se os doentes não forem tratados eficazmente na fase inicial, a doença pode evoluir para malária grave, cujas manifestações mais comuns no adulto são coma, acidose metabólica, insuficiência renal, icterícia grave, lesão pulmonar aguda e ARDS. A malária grave apresenta uma taxa de mortalidade alta, mesmo com tratamento adequado. Apresentamos o caso de um doente com malária grave, secundária a co-infecção pelo P. falciparum e P. ovale, com disfunção multiorgânica, que evoluiu favoravelmente após internamento na Unidade de Cuidados Intensivos. Malaria is caused by infection by protozoa of the genus Plasmodium, and is a major cause of disease, especially in tropical areas. The diagnosis of malaria is based on clinical suspicion and detection of the parasites in the blood. Plasmodium falciparum is the specie that causes most morbidity and mortality. The effect of multiple species co-infection on clinical outcomes of malaria is uncertain. If patients are not effectively treated in the early stages, the disease may progress to severe malaria, whose most common manifestations in adults are coma, metabolic acidosis, renal failure, severe jaundice, acute lung injury and ARDS. Severe malaria has a high mortality, even with appropriate treatment. We present a patient with severe malaria, secondary to co-infection by P. falciparum and P. ovale, with multiorgan dysfunction, which dramatically improved after admission on Intensive Care Unit.

  17. Discussing the inter-sectoral linkages in Ecuador, with a focus on the oil sector

    Directory of Open Access Journals (Sweden)

    Mercy ORELLANA BRAVO

    2015-12-01

    Full Text Available The oil sector represents a key-sector of the Ecuadorian economy, characterised by a high level of value added and a high weight in the national exports. This paper tries to find out whether the oil sector is able to induce positive effects for other economic sectors, and to also measure these effects in comparison with those generated by other sectors. The empirical analysis uses the income and employment multipliers, which are derived from Leontief Input-Output tables. The results indicate that the Ecuadorian oil sector is the most independent one, so that policies enhancing stronger linkages with other sectors are highly recommended.

  18. INTER SECTOR LABOR MOBILITY IN PALEMBANG, INDONESIA

    Directory of Open Access Journals (Sweden)

    Neneng Miskiyah

    2017-06-01

    Full Text Available This study discusses the inter sector labor mobility in Palembang working in the primary, secondary, and tertiary sectors. In this study, the inter sector labor mobility is divided into three (3 categories: (1 a new sector of new type of job, (2 a new sector of same type of job, and (3 the same sector of same type of job. The data used are the cross section data obtained through field surveys. By using multinomial logistic regression model, the results indicate that the variable income, job experience, education, and the number of family members significantly influence the inter sector labor mobility on category 1 compared to category 3. Meanwhile on category 2 compared to category 3, the variables that significantly influence the mobility are income and job security.

  19. Cantor polynomials for semigroup sectors

    OpenAIRE

    Nathanson, Melvyn B.

    2013-01-01

    A packing function on a set Omega in R^n is a one-to-one correspondence between the set of lattice points in Omega and the set N_0 of nonnegative integers. It is proved that if r and s are relatively prime positive integers such that r divides s-1, then there exist two distinct quadratic packing polynomials on the sector {(x,y) \\in \\R^2 : 0 \\leq y \\leq rx/s}. For the rational numbers 1/s, these are the unique quadratic packing polynomials. Moreover, quadratic quasi-polynomial packing function...

  20. Discrete symmetries from hidden sectors

    Energy Technology Data Exchange (ETDEWEB)

    Anastasopoulos, Pascal [Institut für Theoretische Physik, Technische Universität Wien,A-1040 Vienna (Austria); Richter, Robert [II. Institut für Theoretische Physik, Hamburg University,Hamburg (Germany); Schellekens, A.N. [NIKHEF,Science Park 105, 1098 XG Amsterdam (Netherlands); IMAPP, Radboud Universiteit Nijmegen,Nijmegen (Netherlands); Instituto de Física Fundamental, CSIC,Madrid (Spain)

    2015-06-29

    We study the presence of abelian discrete symmetries in globally consistent orientifold compactifications based on rational conformal field theory. We extend previous work http://dx.doi.org/10.1016/j.nuclphysb.2012.08.008 by allowing the discrete symmetries to be a linear combination of U(1) gauge factors of the visible as well as the hidden sector. This more general ansatz significantly increases the probability of finding a discrete symmetry in the low energy effective action. Applied to globally consistent MSSM-like Gepner constructions we find multiple models that allow for matter parity or Baryon triality.

  1. Controllership in the public sector.

    Science.gov (United States)

    Thompson, F; Jones, L R

    1986-01-01

    Ineffective or incompetent controllership is, perhaps, the most common managerial failure found in the public sector. This failure affects outcomes and achievements in every area of public policy--often profoundly. Controllers design and operate management control systems. The effectiveness of alternative control system designs depends upon the cost and production behavior of the good or service in question. But control strategies are seldom consciously or effectively matched to circumstances. As a consequence, public programs are too often simultaneously overcontrolled and out of control.

  2. Power sector reforms in India

    Energy Technology Data Exchange (ETDEWEB)

    Bajaj, Harbans L.; Sharma, Deepak

    2007-07-01

    India faces endemic electrical energy and peaking shortages. The Power Sector is plagued with mounting commercial losses due various inefficiencies, colossal commercial and technical losses and increasing subsidy burden on the states. These shortages have had a very detrimental effect on the overall economic growth of the country. In order to re-vitalise the sector and improve the techno-economic performance, the Government of India has initiated the reform process in 1991. This paper analyses the pre-reform era and identifies the key concerns which led to the initiation of the reforms. It also analyses the likely impact of the major policy and regulatory initiatives that have been undertaken since 1991 including the provisions of the new enactments which have come into force eventually in the form of The Electricity Act, 2003. This paper details out the key features of the Act and its likely impact on the Indian electricity industry in the emerging scenario. The paper also discusses major issues like power trading, role of regulator in the new regime, issue of open access, introduction of power markets and role of Appellate Tribunal for Electricity in harmonizing the orders of the various regulators.

  3. Associação da sulfametoxazol ao trimethoprim no tratamento da malária por Plasmodium falciparum

    Directory of Open Access Journals (Sweden)

    Joaquim Caetano de Almeida Netto

    1972-02-01

    Full Text Available A associação da suljametoxazol (SMZ ao Trimelhoprim (TMP foi ensaiada em 40 portadores de malária pelo Plasmodium falciparum, em duas etapas. Na primeira, foram observados 20 pacientes resistentes às 4-aminoquinoleinas. oligossintomáticos e com densidade parasitária baixa. A administração de 800 mg de SMZ + 160 mg de TMP a dez pacientes, em dose única, bem como, diariamente, durante 2 dias, a 10 outros, se mostrou capaz de promover o desaparecimento dos trofozitos do sangue periférico em todos os 20 casos. Seis dentre 13 pacientes deste grupo apresentaram recrudescência da parasitemia assexuada durante o período de controle, de 30 dias. Não foram observadas manifestações de intolerância. Na segunda etapa foram observados mais 20 pacientes também, em sua maioria, resistentes às 4-aminoquinoleinas, incluindo agora casos com quadro clínico severo. A administração de 1.600 mg SMZ + 320 mg de TMP, diariamente, durante 4 dias. promoveu a negativação de parasitemia assexuada em todos os pacientes dentro de um período de 82 a 96 horas. Deste grupo, 2 dentre os 20 pacientes apresentaram recrudescência clinica e parasitária no período de controle. Apenas 1 teve discreta anemia megaloblastica após o tratamento, que desapareceu espontâneamente.

  4. Vaccine coverage and adherence to EPI schedules in eight resource poor settings in the MAL-ED cohort study.

    Science.gov (United States)

    Hoest, Christel; Seidman, Jessica C; Lee, Gwenyth; Platts-Mills, James A; Ali, Asad; Olortegui, Maribel Paredes; Bessong, Pascal; Chandyo, Ram; Babji, Sudhir; Mohan, Venkata Raghava; Mondal, Dinesh; Mahfuz, Mustafa; Mduma, Estomih R; Nyathi, Emanuel; Abreu, Claudia; Miller, Mark A; Pan, William; Mason, Carl J; Knobler, Stacey L

    2017-01-11

    Launched in 1974, the Expanded Program on Immunization (EPI) is estimated to prevent two-three million deaths annually from polio, diphtheria, tuberculosis, pertussis, measles, and tetanus. Additional lives could be saved through better understanding what influences adherence to the EPI schedule in specific settings. The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) study followed cohorts in eight sites in South Asia, Africa, and South America and monitored vaccine receipt over the first two years of life for the children enrolled in the study. Vaccination histories were obtained monthly from vaccination cards, local clinic records and/or caregiver reports. Vaccination histories were compared against the prescribed EPI schedules for each country, and coverage rates were examined in relation to the timing of vaccination. The influence of socioeconomic factors on vaccine timing and coverage was also considered. Coverage rates for EPI vaccines varied between sites and by type of vaccine; overall, coverage was highest in the Nepal and Bangladesh sites and lowest in the Tanzania and Brazil sites. Bacillus Calmette-Guérin coverage was high across all sites, 87-100%, whereas measles vaccination rates ranged widely, 73-100%. Significant delays between the scheduled administration age and actual vaccination date were present in all sites, especially for measles vaccine where less than 40% were administered on schedule. A range of socioeconomic factors were significantly associated with vaccination status in study children but these results were largely site-specific. Our findings highlight the need to improve measles vaccination rates and reduce delayed vaccination to achieve EPI targets related to the establishment of herd immunity and reduction in disease transmission. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  5. «Gente de mal vivir»: families and incorrigible sons in new Spain, 1721-1729

    Directory of Open Access Journals (Sweden)

    Cáceres Menéndez, Beatriz

    2006-08-01

    Full Text Available Forced transportation to the Philippine and Mariana Islands, a form of social exile and the equivalent of deportation, was used in New Spain to punish criminals and people judged to be undesirable. Those who were sent across the Pacific were always male and usually American-born Spaniards. Both the viceregal government and parents thought forced transportation to be an appropriate way to rid Mexico not only of criminals but also of men «of evil living» - people whose lives were dedicated to gambling, public drunkenness, idleness, and immorality. Parents, brothers, and even wives therefore used forced transportation to eliminate unwanted family members whose behavior threatened to tarnish family honor.

    En la Nueva España el traslado forzoso de individuos a las Islas Filipinas y Marianas fue una forma de exilio equivalente a la deportación para castigar a los criminales y a la gente considerada indeseable. Los condenados fueron siempre hombres y usualmente españoles nacidos en América. Tanto el gobierno virreinal como los padres de familia pensaron en el traslado forzoso como un medio apropiado para limpiar el Reino no sólo de criminales sino también de «gente de mal vivir», es decir, aquellos dedicados al juego, la embriaguez pública, la ociosidad y la inmoralidad. Padres, hermanos y aún esposas utilizaron el traslado obligado como un medio para eliminar a los familiares cuyos comportamientos amenazaban manchar el honor de la familia.

  6. Responsible leader behavior in health sectors.

    Science.gov (United States)

    Longest, Beaufort

    2017-02-06

    Purpose The purpose of this paper is to expand attention to responsible leader behavior in the world's health sectors by explaining how this concept applies to health sectors, considering why health sector leaders should behave responsibly, reviewing how they can do so, and asserting potential impact through an applied example. Design/methodology/approach This paper is a viewpoint, reflecting conceptualizations rooted in leadership literature which are then specifically applied to health sectors. A definition of responsible leader behavior is affirmed and applied specifically in health sectors. Conceptualizations and viewpoints about practice of responsible leader behavior in health sectors and potential consequences are then discussed and asserted. Findings Leadership failures and debacles found in health, but more so in other sectors, have led leadership researchers to offer insights, many of them empirical, into the challenges of leadership especially by more clearly delineating responsible leader behavior. Practical implications Much of what has been learned in the research about responsible leader behavior offers pathways for health sector leaders to more fully practice responsible leadership. Social implications This paper asserts and provides a supporting example that greater levels of responsible leader behavior in health sectors hold potentially important societal benefits. Originality/value This paper is the first to apply emerging conceptualizations and early empirical findings about responsible leader behavior specifically to leaders in health sectors.

  7. AGENCY PROBLEMS IN PUBLIC SECTOR

    Directory of Open Access Journals (Sweden)

    Gyorgy Attila

    2012-07-01

    Full Text Available Agency theory analyses the effects of contractual behaviour between two parties: principal(s and agent(s. This relation is inevitably characterized by information asymmetry because agent holds a substantially larger volume of information than the principal. Due the negative effects of information asymmetry for the principal, this should cover supplementary costs with monitoring agents and/or grant incentives. The first objective of this paper is to emphasize the effects of information asymmetry, particularly on adverse selection and moral hazard. The second objective is to evaluate the negative effects of information asymmetry and to assess the viability of solutions proposed by scholars for mitigation. The third objective is linked with personal contribution, respectively to highlight specificity of agency theory in public sector and the mechanisms of action in this particular field. In this paper, literature is mainly based on scholars’ contribution to the proposed theme. Little literature approaches agency theory in public sector, in most cases the analysis being restricted to general issues. Research methodology is based on synthesizing relevant information from literature and adapting them to public sector particularities. The results reflect some threats for public bodies in their contracting activity. Conclusions present also a set of solutions which could be used by public institutions to optimize their activity of mitigating information asymmetry’s effects. These solution guidelines could represent a useful instrument for make more efficient public money spending. Personal contribution and the novelty of this paper consist in presenting a new approach regarding mechanisms of managing information by agents. In case of public institutions, principals have more opportunities the take possession over the information managed by the agent. Nevertheless, agents can limit the principal’s access

  8. Mergers & Acquisitions in India: A sectoral analysis

    Directory of Open Access Journals (Sweden)

    Priya Bhalla

    2014-07-01

    Full Text Available Globalization, deregulation and technological improvements have resulted in increase in M&A across the globe. There is enormous literature existing in the advanced economies. However, very little information is available regarding M&A in India. Various sectors have witnessed differential involvement in M&A activity indicating higher participation by some. Particularly, certain sectors such as financial services and pharmaceuticals demonstrate higher M&A activity. To emphasise differential importance of sectors in M&A activity, it is necessary to conduct a sector-wise analysis. Accordingly, this study attempts to investigate the differential representation of various sectors in M&A. Further, it explores the role played by India in the rising global M&A activity. In light of this, it specifies the factors driving consolidation in the financial sector globally.

  9. Financial Sector Structure and Economic Growth

    DEFF Research Database (Denmark)

    Rapp, Marc Steffen

    that over time equity financing (bank credit) becomes more (less) important for the corporate sector in developed economies. Third, it reports novel country-level evidence on the link between financial sector structure and economic growth in developed economies. The results suggest that the capital market......Economists consider a well-functioning financial sector to be of first order importance for a modern (capitalist) economy. However, in the aftermath of the financial crisis a debate about the future role of the financial sector emerged and many commentators have called into question whether...... the financial sector actually creates value for the wider society. This research, which is part of a broad research project “Nordic Finance and the Good Society”, aims to contribute to this debate by studying the role of the financial sector structure for economic development of an economy. Therefore...

  10. Commercial sector can improve access.

    Science.gov (United States)

    Finger, W R

    1998-01-01

    This article discusses the improved accessibility to family planning (FP) services made possible by expanding services among private physicians and through social marketing in developing countries. Encouraging private sector (PS) FP is a way to ease the caseload of public FP facilities and creating the potential for attracting more lower-income clients. Few developing countries have a "viable commercial market" for contraceptives. Commercial success depends upon a secure supply of FP supplies, well-trained providers, and consumer demand. Consumers want affordable, high-quality, and convenient services. Governments must ensure that regulations do not hamper PS programs. Public and private programs should not compete in ways that are counterproductive. The commercial sector includes private physicians, clinics, pharmacies, or hospitals without public subsidies. Public funding might be used to encourage PS distribution, especially condoms and messages about HIV and sexually transmitted disease prevention. Messages may target specific audiences and promote an appealing logo and packaging. SOMARC in Turkey promotes a network of commercial health care facilities that offer high quality FP at affordable prices. The model includes provider training, quality of care monitoring, marketing, a hotline, posted prices, and prices set by consumer affordability surveys. This model is being tried in both Nepal and the Philippines. Commercial marketing has been successful in Latin America, North Africa, and the Middle East. Commercial expansion and survival is dependent upon the satisfaction of consumer preferences for convenience, greater access, better confidentiality, and quality. Examples from Zimbabwe and Romania are used to show strategies for training private providers. Private providers will become involved, for instance, by offering targeted training programs.

  11. Third sector primary care for vulnerable populations.

    Science.gov (United States)

    Crampton, P; Dowell, A; Woodward, A

    2001-12-01

    This paper aims to describe and explain the development of third sector primary care organisations in New Zealand. The third sector is the non-government, non-profit sector. International literature suggests that this sector fulfils an important role in democratic societies with market-based economies, providing services otherwise neglected by the government and private for-profit sectors. Third sector organisations provided a range of social services throughout New Zealand's colonial history. However, it was not until the 1980s that third sector organisations providing comprehensive primary medical and related services started having a significant presence in New Zealand. In 1994 a range of union health centres, tribally based Mäori health providers, and community-based primary care providers established a formal network -- Health Care Aotearoa. While not representing all third sector primary care providers in New Zealand, Health Care Aotearoa was the best-developed example of a grouping of third sector primary care organisations. Member organisations served populations that were largely non-European and lived in deprived areas, and tended to adopt population approaches to funding and provision of services. The development of Health Care Aotearoa has been consistent with international experience of third sector involvement -- there were perceived "failures" in government policies for funding primary care and private sector responses to these policies, resulting in lack of universal funding and provision of primary care and continuing patient co-payments. The principal policy implication concerns the role of the third sector in providing primary care services for vulnerable populations as a partial alternative to universal funding and provision of primary care. Such an alternative may be convenient for proponents of reduced state involvement in funding and provision of health care, but may not be desirable from the point of view of equity and social cohesion

  12. Cybersecurity Public Sector Threats and Responses

    CERN Document Server

    Andreasson, Kim J

    2011-01-01

    The Internet has given rise to new opportunities for the public sector to improve efficiency and better serve constituents in the form of e-government. But with a rapidly growing user base globally and an increasing reliance on the Internet, digital tools are also exposing the public sector to new risks. An accessible primer, Cybersecurity: Public Sector Threats and Responses focuses on the convergence of globalization, connectivity, and the migration of public sector functions online. It identifies the challenges you need to be aware of and examines emerging trends and strategies from around

  13. Industrial Disputes in the Construction Sector

    Directory of Open Access Journals (Sweden)

    L.J Perry

    2012-11-01

    Full Text Available The Cole Royal Commission enquiry into the building and construction (abbreviated to ‘construction’ sector recommended controversial workplace-relation reforms for that sector. The recommended changes are likely to be enshrined in legislation within the year. The Commission drew on analyses of industrial disputes that focused, in the main, on quite recent experience. This paper attempts to give a broader historical perspective on disputes in that sector by considering the pattern of disputes for the entire post-World War II period. Accordingly, data on disputes and employees during the entire period are gathered from Australian Bureau of Statistics current and archived sources. These data are classified according to sector (construction versus non-construction and analysed. It is found that the strike rate has, on average, been greater in the construction sector than in the non-construction sector. However, there have been periods during which disputes in the construction sector have been relatively low. The most recent period was during the period of the Accord (1983-96, during which the strike rate in the construction sector fell relatively strongly. The analysis of this relatively broad historical period draws attention, among other things, to the possibility that the sort of strategies employed during the Accord years – strategies of cooperation and consensus building – may provide a more effective means of bringing industrial peace to the workplace relations scene of the construction sector than policies that are relatively confrontational.

  14. Comparing public and private sector switchers

    DEFF Research Database (Denmark)

    Frederiksen, Anders; Hansen, Jesper Rosenberg; Bozeman, Barry

    Sector switching is a new rising research area. Little is known about the motives and behaviors of those switching sectors. Using Person-Environment (P-E) fit theory, we seek to determine whether familiar demographic characteristics, including age, gender, having children and length of education...... labor market data that include information on all employees in Denmark (both private and public sector). The data are for the period 1980 to 2006, and this longitudinal database includes abundant information about job changes, including sector switching. Our findings indicate mixed support...

  15. Synthesis, characterization and crystal structures of two discrete Cu(II) complexes with mixed-ligands: [Cu(mal)(L)(H2O)]·H2O and [Cu(Phmal)(L)2] (mal=malonate dianion, phmal=phenylmalonate dianion and L=5,5‧-dimethyl-2,2‧-bipyridine)

    Science.gov (United States)

    Cui, Guang-Hua; Li, Jian-Rong; Hu, Tong-Liang; Bu, Xian-He

    2005-03-01

    Two new Cu(II) complexes with mixed ligands, [Cu(mal)( L)(H 2O)]·H 2O ( 1) and [Cu(phmal)( L)] 2 ( 2) (mal=malonate dianion, phmal=phenylmalonate dianion, L=5,5'-dimethyl-2,2'-bipyridine) have been synthesized and characterized by elemental analyses, IR, UV-vis and X-ray single crystal diffraction. In both complexes the Cu(II) ions take five-coordinated square pyramidal geometry. 1 has a mononuclear structure, and assembles into a 2D supramolecular network by hydrogen bonding. 2 is a dinuclear complex, and also forms 2D framework via π-π interactions. The structural differences of the two complexes may be attributed to the variation of the substituted group of malonate dianion.

  16. MosquitoMap and the Mal-area calculator: new web tools to relate mosquito species distribution with vector borne disease

    Directory of Open Access Journals (Sweden)

    Christensen Jamie

    2010-02-01

    Full Text Available Abstract Background Mosquitoes are important vectors of diseases but, in spite of various mosquito faunistic surveys globally, there is a need for a spatial online database of mosquito collection data and distribution summaries. Such a resource could provide entomologists with the results of previous mosquito surveys, and vector disease control workers, preventative medicine practitioners, and health planners with information relating mosquito distribution to vector-borne disease risk. Results A web application called MosquitoMap was constructed comprising mosquito collection point data stored in an ArcGIS 9.3 Server/SQL geodatabase that includes administrative area and vector species x country lookup tables. In addition to the layer containing mosquito collection points, other map layers were made available including environmental, and vector and pathogen/disease distribution layers. An application within MosquitoMap called the Mal-area calculator (MAC was constructed to quantify the area of overlap, for any area of interest, of vector, human, and disease distribution models. Data standards for mosquito records were developed for MosquitoMap. Conclusion MosquitoMap is a public domain web resource that maps and compares georeferenced mosquito collection points to other spatial information, in a geographical information system setting. The MAC quantifies the Mal-area, i.e. the area where it is theoretically possible for vector-borne disease transmission to occur, thus providing a useful decision tool where other disease information is limited. The Mal-area approach emphasizes the independent but cumulative contribution to disease risk of the vector species predicted present. MosquitoMap adds value to, and makes accessible, the results of past collecting efforts, as well as providing a template for other arthropod spatial databases.

  17. Heterogeneity in the properties of mutant secreted lymphocyte antigen 6/urokinase receptor-related protein 1 (SLURP1) in Mal de Meleda

    DEFF Research Database (Denmark)

    Adeyo, Oludotun; Oberer, Monika; Ploug, M

    2015-01-01

    Genetic defects in SLURP1, a "lymphocyte antigen 6" (Ly6)-like protein, cause mal de Meleda, a palmoplantar keratoderma (PPK). The hallmark of Ly6 proteins is an 80-amino acid domain containing 10 cysteines, all arranged in a characteristic spacing pattern and all disulfide-bonded, creating a thr......-fingered structural motif (Fig. 1). This sequence motif was initially found in cobra and viper toxins, but was later identified in ~25 mammalian proteins. This article is protected by copyright. All rights reserved....

  18. Sobre los saberes culturales y el fenómeno "sentirse bien-sentirse mal" On cultural knowledge and the phenomenon "feel good-fell bad"

    Directory of Open Access Journals (Sweden)

    Virtudes Rodero Sánchez

    2010-09-01

    Full Text Available El objetivo del presente estudio es identificar los saberes culturales inmersos en el fenómeno "sentirse-bien, sentirse mal", en diferentes situaciones de cuidado. Se elaboró un estudio cualitativo con un enfoque fenomenológico interpretativo, mediante el análisis de 18 narrativas a partir de entrevistas en profundidad realizadas por alumnas del Máster en Ciencias de la Enfermería en diferentes contextos de cuidados. Las categorías identificadas fueron: (1 Cronicidad y concepto de sentirse bien-sentirse mal. En la cronicidad este concepto está íntimamente relacionado con la recuperación de las actividades de la vida diaria y es componente importante en la percepción individual del concepto "calidad de vida". (2 Momentos agudos de enfermedad y concepto de sentirse bien-sentirse mal. En el análisis de los relatos del paciente aparecieron aspectos esenciales del fenómeno "sentirse bien-sentirse mal" para aumentar la comprensión de aspectos universales de algunos de sus componentes. Destacar que el fenómeno está íntimamente relacionado con la recuperación de las actividades de la vida diaria, y es un mediador importante en la percepción individual del concepto "calidad de vida". El interés de cara al cuidado es distinguir sus componentes universales, contextualizarlos en la práctica, dentro de las singularidades que presenta cada persona, de modo que nos permita su potenciación. El resultado es un cambio en la experiencia sentida.The object of the present study is to identify cultural knowledges immersed in the feeling-well, feeling-bad phenomenon in different care settings. A qualitative study was undertaken using a phenomenological interpretation approach through a meta-analysis of 18 narratives of profound interviews undertaken by Nursing Science Master Degree Students in different care situations. The categories established were: (1 Chronicity and the concept of feeling well-feeling bad. In this category, this concept is

  19. Evaluación de métodos de curación de sustratos para la prevención del mal de talluelo

    OpenAIRE

    Solano-Bonilla, María; Estudiante Escuela Ing. Forestal Instituto Tecnológico de Costa Rica; Brenes-Chacón, Denia; Estudiante Escuela Ing. Forestal Instituto Tecnológico de Costa Rica

    2012-01-01

    Se evaluó el efecto de diferentes tratamientos (Vitavax, Orthocide, solarización y testigo), sobre porciones de suelo inoculado con Fusarium spp, en la etapa de germinación de cedro dulce (Cedrela tonduzii). Este hongo es uno de los causantes del mal del talluelo en la etapa temprana de muchas especies, influyendo negativamente en el crecimiento y desarrollo de las plantas. El tratamiento que obtuvo mayor porcentaje de germinación de la semilla y crecimiento de las plantas fue el de solarizac...

  20. Mal de Montaña, migraña y depresión: Coexistencia casual o causal? Posible rol de la hipoxia ambiental.

    Directory of Open Access Journals (Sweden)

    Alberto Arregui

    1995-10-01

    Full Text Available Objetivo: Estudiar la posible asociación entre mal de montaña crónico, migraña y depresión. Material y métodos: Estudio epidemiológico realizado en setiembre de 1990en 379 hombres adultos con residencia permanente en la ciudad de Cerro de Pasco (4300 m.s.n.m.; se hicieron 15 preguntas asociadas a depresión y 9 preguntas asociadas al mal de montaña crónico (MMC con las que se calcularon puntajes de depresión y del mal de montaña crónico. Los puntajes por encima de dos desviaciones estándar de la media fueron considerados como altos. Resultados: La frecuencia de migrañas fue de 48.3% entre hombres con puntajes altos de MMC y de 26.5% entre aquellos con puntajes normales (p=0.013. El 16.7% de hombres con puntaje alto de MMC tuvo puntaje alto de depresión mientras que sólo el 6.5% con puntaje normal de MMC tuvo puntaje alto de depresión (p=0.04. El riesgo de tener puntaje alto de depresión o de MMC fue más del doble entre hombres con migrañas comparados con hombres sin migrañas. La posibilidad de tener migraña o puntajes alto de MMC, fue tres veces mayor entre hombres con puntajes alto de depresión comparados con los que tuvieron puntajes de MMC más altos que aquellos sin cefaleas o con otros tipos de cefaleas. Conclusiones: Los datos muestran una coexistencia más que casual entre estas tres entidades clínicas. Se sugiere que un factor de riesgo común a las tres sea la hipoxia crónica que podría producir cambios neuroquímicos en el cerebro que explicaría, en parte, los síntomas de estos tres síndromes. Los datos también sugieren que los síntomas subjetivos que ocurren en el mal de montaña crónico son similares a los que ocurren en la depresión. (Rev Med Hered 1996; 6: 163-167.

  1. A banalização do mal: sobre Auschwitz, a religião do cotidiano e a teoria social

    Directory of Open Access Journals (Sweden)

    Detlev Claussen

    2013-07-01

    Full Text Available Neste artigo, traduzido para o português por Rodrigo Duarte, Detlev Claussen discute a banalização do mal a partir da relação da indústria cultural com Auschwitz. O autor sugere que a substituição dessa palavra pelo termo mais geral “holocausto” é uma das estratégias empregadas pelos meios de massa para trivializar a comunicabilidade do que se passou nesse campo de concentração – uma experiência que permanece essencialmente incomunicável.

  2. Synthesis, crystal structure and magnetic properties of [Cu(mal(abpt(H2O].3/2H2O and [Cu2(sq(abpt 2].2H2O (mal = malonate, sq = squarate, abpt = 4-amino-3,5-di-2-pyridyl-4H-1,2,4 triazole

    Directory of Open Access Journals (Sweden)

    Eno A. Ededet

    2011-04-01

    Full Text Available Two new mixed-ligand complexes of formula [Cu(mal(abpt(H2O].3/2H2O (1 and [Cu2(sq(abpt2].2H2O (2 [mal = malonate, abpt = 4-amino-3,5-di-2-pyridyl-4H-1,2,4 triazole and sq = squarate], have been prepared and characterized by X-ray crystal structure determination and magnetic studies. Complex 1 crystallizes in the monoclinic system, space group C2/c, with a = 14.0086(2 Å, b = 10.0980(2 Å, c = 25.630(4 Å; β = 97.5900(10 o, and Z = 8. Complex 2 crystallizes in the triclinic system, space group P-1 with a = 7.5696(15 Å, b = 8.4697(17 Å, c = 11.049(2 Å; β = 93.00(3o, α = 96.98(3, γ = 90.111(3 and Z = 1. Complex 1 consist of a neutral mononuclear [Cu(mal(abpt(H2O] unit and water molecule of crystallization in a distorted square pyramidal coordination sphere, while complex 2 is viewed as being made up of [Cu(sq(abpt2] units with the squarato ligand bridging the two copper(II cations. Variable temperature magnetic behaviour of the complexes reveals the existence of weak antiferromagnetic interaction for complex 1 and weak ferromagnetic intrachain interaction for complex 2.

  3. Determinants and Impact of Giardia Infection in the First 2 Years of Life in the MAL-ED Birth Cohort.

    Science.gov (United States)

    Rogawski, Elizabeth T; Bartelt, Luther A; Platts-Mills, James A; Seidman, Jessica C; Samie, Amidou; Havt, Alexandre; Babji, Sudhir; Trigoso, Dixner Rengifo; Qureshi, Shahida; Shakoor, Sadia; Haque, Rashidul; Mduma, Estomih; Bajracharya, Samita; Gaffar, S M Abdul; Lima, Aldo A M; Kang, Gagandeep; Kosek, Margaret N; Ahmed, Tahmeed; Svensen, Erling; Mason, Carl; Bhutta, Zulfiqar A; Lang, Dennis R; Gottlieb, Michael; Guerrant, Richard L; Houpt, Eric R; Bessong, Pascal O

    2017-06-01

    Giardia are among the most common enteropathogens detected in children in low-resource settings. We describe here the epidemiology of infection with Giardia in the first 2 years of life in the Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED), a multisite birth-cohort study. From 2089 children, 34916 stool samples collected during monthly surveillance and episodes of diarrhea were tested for Giardia using an enzyme immunoassay. We quantified the risk of Giardia detection, identified risk factors, and assessed the associations with micronutrients, markers of gut inflammation and permeability, diarrhea, and growth using multivariable linear regression. The incidence of at least 1 Giardia detection varied according to site (range, 37.7%-96.4%) and was higher in the second year of life. Exclusive breastfeeding (HR for first Giardia detection in a monthly surveillance stool sample, 0.46 [95% confidence interval (CI), 0.28-0.75]), higher socioeconomic status (HR, 0.74 [95% CI, 0.56-0.97]), and recent metronidazole treatment (risk ratio for any surveillance stool detection, 0.69 [95% CI, 0.56-0.84]) were protective. Persistence of Giardia (consecutive detections) in the first 6 months of life was associated with reduced subsequent diarrheal rates in Naushahro Feroze, Pakistan but not at any other site. Giardia detection was also associated with an increased lactulose/mannitol ratio. Persistence of Giardia before 6 months of age was associated with a -0.29 (95% CI, -0.53 to -0.05) deficit in weight-for-age z score and -0.29 (95% CI, -0.64 to 0.07) deficit in length-for-age z score at 2 years. Infection with Giardia occurred across epidemiological contexts, and repeated detections in 40% of the children suggest that persistent infections were common. Early persistent infection with Giardia, independent of diarrhea, might contribute to intestinal permeability and stunted

  4. COMPETITION IN ROMANIAN BANKING SECTOR

    Directory of Open Access Journals (Sweden)

    Capraru Bogdan

    2011-07-01

    Full Text Available Recent turmoil in the global financial system has impacted severely on the banking sector with many banks suffering large losses and necessitating the need to raise additional capital privately or through their respective national governments. In our study we investigate the impact of structural reforms performed throughout the European Union (EU accession process on competition and contestability of banking systems in Romania. The literature of the measurement of competition can be divided into two major approaches: structural and non-structural. The structural approach to the assessment of competition embraces the Structure-Conduct-Performance Hypothesis (SCP and the Efficient Structure Hypothesis (ESH. The structural approach, as the name suggests, assesses bank competition by examining measures of market structure such as concentration ratios (the share of assets held by the top 3 or 5 institutions or indices (e.g., the Herfindhal-Hirschman index and supposes that higher concentration in the banking market causes less competitive bank conduct and leads to higher bank profitability. The SCP model is originally developed by Bain (1956. The second approach, ESH, developed by Demsetz (1973 and Peltzmann (1977 suggests that the superior performance of the market leaders determines the market structure, implying that higher efficiency produces both higher concentration and greater profitability. The non-structural indicators of competition are mainly based on the measures of monopoly power developed by Lerner (1934. The Lerner Index suggests the mark-up of price over marginal cost. An alternative non-structural indicator of the degree of market competition is the Panzar and Rosse (1987 H-statistic. The H-statistic measures the extent to which changes in banking costs are reflected in changes in banking revenues. In order to examine the level of competition and market power of banks in Romania for period 2003 - 2009, we estimate the non

  5. Industrial innovation and intra sectoral and inter sectoral technology diffusion; Innovacion industrial y difusion tecnological intrasectorial e intersectorial

    Energy Technology Data Exchange (ETDEWEB)

    Serrano Domingo, G.; Cabrera Borras, B.; Requena Silvente, F.

    2012-07-01

    This paper examines whether sectoral backward and forward linkages can generate positive externalises in sectoral innovation through diffusion of technological knowledge, both across countries within a sector or across sectors within a country. Using a sample of 14 OECD countries and 12 sectors over the period 1995-2005 we find that forward linkages enhance sectoral innovation. Intra sectoral slipovers are important among sectors and countries with low-to-medium R an D intensity while inter sectoral slipovers have a major impact on sectors with high R and D intensity. (Author)

  6. Gupta, Dr Chhitar Mal

    Indian Academy of Sciences (India)

    Address: Distinguished Professor and Infosys Chair, Institute of Bioinformatics & Applied Biotechnology, Room No. GF 18, Biotech Park, Electronic city, Bengaluru 560 100, Karnataka Contact: Office: (080) 2852 8900-02/109. Residence: (080) 4090 3534. Email: cm44gupta@gmail.com, drucmg@rediffmail.com. YouTube ...

  7. Malûliyet

    OpenAIRE

    Güçlü, Eda

    2014-01-01

    Bezmez, Dikmen. “Urban Citizenship, the Right to the City and Politics of Disability in Istanbul.” International Journal of Urban and Regional Research 37, no. 1 (January 2013): 93–114. Evcil, An. “Wheelchair Accessibility to Public Buildings in Istanbul.” Disability & Rehabilitation: Assistive Technology 4, no. 2 (March 2009): 76–85. Evcil, Nilay. “Designers’ Attitudes Towards Disabled People and the Compliance of Public Open Places: The Case of Istanbul.” European Planning Studies 18, no. 1...

  8. Impact of private sector credit on the real sector of Nigeria

    Directory of Open Access Journals (Sweden)

    Aliyu Mamman, Ph.D

    2013-07-01

    Full Text Available The real sector is a strategic component of an economy because it produces and distributes tangible goods and services required to satisfy aggregate demand in the economy. For this reason, there is the need for adequate credit flow from the banking industry to the real sector, which in the Nigerian case, the credit flow has been grossly inadequate. This study is carried out to examine the impact of credit to private sector (CPS on the real sector of Nigeria with a view to assess the significant contribution of CPS to real sector growth in Nigeria. The study used aggregate time series data from 1986 to 2010, which was drawn from central bank of Nigeria (CBN statistical bulletin and CBN annual report and statement of accounts. The data was analysed using multiple regression and based on the coefficient of determination (R square, the study reveals a 96.1% variation between the CPS and real sector growth in Nigeria. The study cocludes that there is a statistically significant impact of credit to private sector on the real sector of Nigeria. This, suggest that the performance of the real sector is greatly influence by credit to private sector. The study recommends that the federal government of Nigeria through the central bank of Nigeria (CBN should enhance the financing of the real sector as well as improve credit flow to the sector because of its strategic importance in creating and generating growth of the economy.

  9. Sectoral Innovatiohn Performance in the Biotechnology Sector. Final Report. Task 1

    NARCIS (Netherlands)

    Enzing, C.M.; Valk, T. van der

    2010-01-01

    In general the biotechnology sector can be qualified as a science driven and high tech sector. This applies for both the group of biotech start-ups that are present in each of the three sub-sectors (red biotech: health/pharma, green biotech: agrifood and white biotech: chemicals) as for the red

  10. Poverty Reduction through Private Sector Development : Policy ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Poverty Reduction through Private Sector Development : Policy Research on Micro, Small and Medium Enterprises. The Palestinian Authority aims to turn the economy away from its dependence on the public sector toward a diversified free market economy. Small businesses, which make up more that 90% of the total ...

  11. Labor Adjustment Costs across Sectors and Regions

    OpenAIRE

    Olarreaga,Marcelo; Milet, Emmanuel; Cruz, Marcio

    2017-01-01

    This paper estimates the mobility costs of workers across sectors and regions in a large sample of developing countries. The paper develops a new methodology that uses cross-sectional data only. This is motivated by the fact that panel data typically are not available for most developing countries. The results suggest that, on average, sector mobility costs are higher than regional mobilit...

  12. Rights of Access to Public Sector Information

    NARCIS (Netherlands)

    van Eechoud, M.; Janssen, K.

    2012-01-01

    This paper was written in the context of the European Commission funded thematic network on Legal Aspects of Public Sector Information ('LAPSI'). The reliance on national access norms is an important feature of the EU’s re-use framework, of which Directive 2003/98/EC on the re-use of public sector

  13. The first LHC sector is fully interconnected

    CERN Document Server

    2006-01-01

    Sector 7-8 is the first sector of the LHC to become fully operational. All the magnets, cryogenic line, vacuum chambers and services are interconnected. The cool down of this sector can soon commence. LHC project leader Lyn Evans, the teams from CERN's AT/MCS, AT/VAC and AT/MEL groups, and the members of the IEG consortium celebrate the completion of the first LHC sector. The 10th of November was a red letter day for the LHC accelerator teams, marking the completion of the first sector of the machine. The magnets of sector 7-8, together with the cryogenic line, the vacuum chambers and the distribution feedboxes (DFBs) are now all completely interconnected. Sector 7-8 has thus been closed and is the first LHC sector to become operational. The interconnection work required several thousand electrical, cryogenic and insulating connections to be made on the 210 interfaces between the magnets in the arc, the 30 interfaces between the special magnets and the interfaces with the cryogenic line. 'This represent...

  14. Dark Sectors 2016 Workshop: Community Report

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, Jim; et al.

    2016-08-30

    This report, based on the Dark Sectors workshop at SLAC in April 2016, summarizes the scientific importance of searches for dark sector dark matter and forces at masses beneath the weak-scale, the status of this broad international field, the important milestones motivating future exploration, and promising experimental opportunities to reach these milestones over the next 5-10 years.

  15. National Electric Sector Cybersecurity Organization Resource (NESCOR)

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2014-06-30

    The goal of the National Electric Sector Cybersecurity Organization Resource (NESCOR) project was to address cyber security issues for the electric sector, particularly in the near and mid-term. The following table identifies the strategies from the DOE Roadmap to Achieve Energy Delivery Systems Cybersecurity published in September 2011 that are applicable to the NESCOR project.

  16. Presupuesto del sector público

    OpenAIRE

    Universitat de Barcelona. Grup d'Innovació Docent en Economia dels Impostos (GIDEI)

    2016-01-01

    Tema 2. Esquemas de la presentación del tema "Presupuesto del Sector Público. Incorpora datos actuales, gráficos, cuadros y tablas. Esquemes de la presentació del tema "Sector Público: Presupuesto, Dimensión y Componentes". Incorpora dades actuals, gràfics, quadres i taules.

  17. Dark Sectors 2016 Workshop: Community Report

    CERN Document Server

    Alexander, Jim; Echenard, Bertrand; Essig, Rouven; Graham, Matthew; Izaguirre, Eder; Jaros, John; Krnjaic, Gordan; Mardon, Jeremy; Morrissey, David; Nelson, Tim; Perelstein, Maxim; Pyle, Matt; Ritz, Adam; Schuster, Philip; Shuve, Brian; Toro, Natalia; Van De Water, Richard G.; Akerib, Daniel; An, Haipeng; Aniol, Konrad; Arnquist, Isaac J.; Asner, David M.; Back, Henning O.; Baker, Keith; Baltzell, Nathan; Banerjee, Dipanwita; Batell, Brian; Bauer, Daniel; Beacham, James; Benesch, Jay; Bjorken, James; Blinov, Nikita; Boehm, Celine; Bondi, Mariangela; Bonivento, Walter; Bossi, Fabio; Brodsky, Stanley J.; Budnik, Ran; Bueltmann, Stephen; Bukhari, Masroor H.; Bunker, Raymond; Carpinelli, Massimo; Cartaro, Concetta; Cassel, David; Cavoto, Gianluca; Celentano, Andrea; Chaterjee, Animesh; Chaudhuri, Saptarshi; Chiodini, Gabriele; Cho, Hsiao-Mei Sherry; Church, Eric D.; Cooke, D.A.; Cooley, Jodi; Cooper, Robert; Corliss, Ross; Crivelli, Paolo; Curciarello, Francesca; D'Angelo, Annalisa; Davoudiasl, Hooman; De Napoli, Marzio; De Vita, Raffaella; Denig, Achim; deNiverville, Patrick; Deshpande, Abhay; Dharmapalan, Ranjan; Dobrescu, Bogdan; Donskov, Sergey; Dupre, Raphael; Estrada, Juan; Fegan, Stuart; Ferber, Torben; Field, Clive; Figueroa-Feliciano, Enectali; Filippi, Alessandra; Fornal, Bartosz; Freyberger, Arne; Friedland, Alexander; Galon, Iftach; Gardner, Susan; Girod, Francois-Xavier; Gninenko, Sergei; Golutvin, Andrey; Gori, Stefania; Grab, Christoph; Graziani, Enrico; Griffioen, Keith; Haas, Andrew; Harigaya, Keisuke; Hearty, Christopher; Hertel, Scott; Hewett, JoAnne; Hime, Andrew; Hitlin, David; Hochberg, Yonit; Holt, Roy J.; Holtrop, Maurik; Hoppe, Eric W.; Hossbach, Todd W.; Hsu, Lauren; Ilten, Phil; Incandela, Joe; Inguglia, Gianluca; Irwin, Kent; Jaegle, Igal; Johnson, Robert P.; Kahn, Yonatan; Kalicy, Grzegorz; Kang, Zhong-Bo; Khachatryan, Vardan; Kozhuharov, Venelin; Krasnikov, N.V.; Kubarovsky, Valery; Kuflik, Eric; Kurinsky, Noah; Laha, Ranjan; Lanfranchi, Gaia; Li, Dale; Lin, Tongyan; Lisanti, Mariangela; Liu, Kun; Liu, Ming; Loer, Ben; Loomba, Dinesh; Lyubovitskij, Valery E.; Manalaysay, Aaron; Mandaglio, Giuseppe; Mans, Jeremiah; Marciano, W.J.; Markiewicz, Thomas; Marsicano, Luca; Maruyama, Takashi; Matveev, Victor A.; McKeen, David; McKinnon, Bryan; McKinsey, Dan; Merkel, Harald; Mock, Jeremy; Monzani, Maria Elena; Moreno, Omar; Nantais, Corina; Paul, Sebouh; Peskin, Michael; Poliakov, Vladimir; Polosa, Antonio D.; Pospelov, Maxim; Rachek, Igor; Radics, Balint; Raggi, Mauro; Randazzo, Nunzio; Ratcliff, Blair; Rizzo, Alessandro; Rizzo, Thomas; Robinson, Alan; Rubbia, Andre; Rubin, David; Rueter, Dylan; Saab, Tarek; Santopinto, Elena; Schnee, Richard; Shelton, Jessie; Simi, Gabriele; Simonyan, Ani; Sipala, Valeria; Slone, Oren; Smith, Elton; Snowden-Ifft, Daniel; Solt, Matthew; Sorensen, Peter; Soreq, Yotam; Spagnolo, Stefania; Spencer, James; Stepanyan, Stepan; Strube, Jan; Sullivan, Michael; Tadepalli, Arun S.; Tait, Tim; Taiuti, Mauro; Tanedo, Philip; Tayloe, Rex; Thaler, Jesse; Tran, Nhan V.; Tulin, Sean; Tully, Christopher G.; Uemura, Sho; Ungaro, Maurizio; Valente, Paolo; Vance, Holly; Vavra, Jerry; Volansky, Tomer; von Krosigk, Belina; Whitbeck, Andrew; Williams, Mike; Wittich, Peter; Wojtsekhowski, Bogdan; Xue, Wei; Yoon, Jong Min; Yu, Hai-Bo; Yu, Jaehoon; Yu, Tien-Tien; Zhang, Yue; Zhao, Yue; Zhong, Yiming; Zurek, Kathryn

    2016-01-01

    This report, based on the Dark Sectors workshop at SLAC in April 2016, summarizes the scientific importance of searches for dark sector dark matter and forces at masses beneath the weak-scale, the status of this broad international field, the important milestones motivating future exploration, and promising experimental opportunities to reach these milestones over the next 5-10 years.

  18. Climate change adaptation in the water sector

    National Research Council Canada - National Science Library

    Ludwig, Fulco

    2009-01-01

    ... and Peter Droogers 87 8 Climate-proofing Jeroen Veraart and Marloes Bakker 1093388 EARTH CC in Water Sector 6/2/09 1:14 PM Page vi vi Climate Change Adaptation in the Water Sector PART II: CASE S...

  19. El sector público: funciones

    OpenAIRE

    Universitat de Barcelona. Grup d'Innovació Docent en Economia dels Impostos

    2016-01-01

    Tema 1. Esquemas de presentación del tema "Sector Público: Funciones". Incorpora datos actuales, gráficos, cuadros y tablas. Esquemes de la presentació del tema "Sector Públic: Funcions". Incorpora dades actuals, gràfics, quadres I taules.

  20. Industry-driven sector roadmaps 2020

    DEFF Research Database (Denmark)

    Ricard, Lykke Margot

    Industri-driven sector roadmaps 2020: European Technology Platforms in wind and CCS. A new corporate trend on innovation in Europe, supported by The European Commission.......Industri-driven sector roadmaps 2020: European Technology Platforms in wind and CCS. A new corporate trend on innovation in Europe, supported by The European Commission....

  1. FORCE Sectoral Survey on European Retail Trade.

    Science.gov (United States)

    Bertzeletou, Tina

    1993-01-01

    A sectoral survey focused on ways in which vocational training plans are formulated and analysis of the cost effectiveness of continuing vocational training at the company level. It examined techniques applied to developing continuing vocational training and improving access. National surveys carried out for the retail trade sector revealed…

  2. Modernize the Public Sector Through Innovation?

    DEFF Research Database (Denmark)

    Hansson, Finn; Norn, Maria Theresa; Vad, Torben Bundgaard

    2013-01-01

    The article will discuss the challenges related to the use of social science knowledge in innovation processes in the public sector, drawing on a case, an evaluation of the Program on Research for Innovation and Renewal in the Public Sector (abbreviated FIFOS) under the Research Council of Norway...

  3. Financial Sector Competition, Service Trade, and Growth

    NARCIS (Netherlands)

    J.F. François (Joseph); F.W. Eschenbach

    2002-01-01

    textabstractWe explore dynamic linkages between financial/banking sector openness, financial sector competition, and growth. We first develop an analytical model, highlighting links between long-run economic performance and services trade, through scale economies and market and cost structures in

  4. State aid in banking sector

    Directory of Open Access Journals (Sweden)

    Jana Mikušová

    2012-01-01

    Full Text Available The financial crisis has hit Europe with a truly unprecedented power, which has in early 2008 expected only a very small circle of pessimists. After the first cracks began to appear on the mortgage market in the U.S., however, started an avalanche that rolls until today. In today’s globalized world, it would be very naive to believe that this would not have an impact on the European Union internal market.With the crisis in the banking sector, the Member States of the European Union fought against the crisis in various ways. Allocation of the state aid in the first months of the crisis took place within the existing rules, yet it was necessary to enclose these huge expenditures by rules and regulations issued by the European Commission.This article discusses the types of state aid, which were used at the time from the first wave of state aid granted by Member States from 2008 to 2010 and also assess the current situation together with the evaluation of the approach of the European Commission.

  5. Opportunities for business and partnership : services sector

    Energy Technology Data Exchange (ETDEWEB)

    Mendoza Fernandez, J. [Bufete Industrial Construcciones, Mexico City (Mexico)

    1999-07-01

    Mexico is one of the countries with the highest industrial growth in Latin America. This is due to its geographical location, its vast oil and gas reserves, its membership in NAFTA (North American Free Trade Agreement), and mainly because of its modern economic policies. Mexico is a country in which many opportunities for private investment in the energy sector exist. This paper discussed Bufete Industrial Construcciones' involvement and experiences in the fields of petroleum, electricity and natural gas. The goals to be achieved in the various areas of the energy sector for the 2000-2006 period were summarized for the electric sector, the natural gas sector and the oil and gas extraction sector. The 4 mega projects currently underway include the Cantarell, the Burgos, the Ku-Maloob Zaap and the Delta del Grijalva projects.

  6. Opportunities for business and partnership : services sector

    Energy Technology Data Exchange (ETDEWEB)

    Mendoza Fernandez, J. (Bufete Industrial Construcciones, Mexico City (Mexico))

    1999-01-01

    Mexico is one of the countries with the highest industrial growth in Latin America. This is due to its geographical location, its vast oil and gas reserves, its membership in NAFTA (North American Free Trade Agreement), and mainly because of its modern economic policies. Mexico is a country in which many opportunities for private investment in the energy sector exist. This paper discussed Bufete Industrial Construcciones' involvement and experiences in the fields of petroleum, electricity and natural gas. The goals to be achieved in the various areas of the energy sector for the 2000-2006 period were summarized for the electric sector, the natural gas sector and the oil and gas extraction sector. The 4 mega projects currently underway include the Cantarell, the Burgos, the Ku-Maloob Zaap and the Delta del Grijalva projects.

  7. Opportunities for business and partnership : services sector

    Energy Technology Data Exchange (ETDEWEB)

    Mendoza Fernandez, J. [Bufete Industrial Construcciones, Mexico City (Mexico)

    1999-10-01

    Mexico is one of the countries with the highest industrial growth in Latin America. This is due to its geographical location, its vast oil and gas reserves, its membership in NAFTA (North American Free Trade Agreement), and mainly because of its modern economic policies. Mexico is a country in which many opportunities for private investment in the energy sector exist. This paper discussed Bufete Industrial Construcciones` involvement and experiences in the fields of petroleum, electricity and natural gas. The goals to be achieved in the various areas of the energy sector for the 2000-2006 period were summarized for the electric sector, the natural gas sector and the oil and gas extraction sector. The 4 mega projects currently underway include the Cantarell, the Burgos, the Ku-Maloob Zaap and the Delta del Grijalva projects.

  8. Modelling Transition Towards Sustainable Transportation Sector

    DEFF Research Database (Denmark)

    Dominkovic, Dominik Franjo; Bačeković, I.; Mýrdal, Jón Steinar Garðarsson

    2016-01-01

    In a transition towards 100% renewable energy system, transportation sector is rarely dealt withusing the holistic approach and measuring its impact on the whole energy system. Furthermore, assolutions for power and heat sectors are clearer, it is a tendency of the researchers to focus on thelatter...... two energy sectors. In order to deal with the raised issue, authors of this paper developed amethodology for calculation of the transition towards sustainable transport sector, focusing on thesolutions that are already available. Furthermore, as a part of the model, a detailed mapping ofresources...... needed has been carried out for each of the alternatives. It was shown that theelectrification of the transportation sector is a crucial point in transition, while for the transportmodes that cannot be electrified, or shifted to different transportation modes, four alternatives weredefined: synthetic...

  9. Avaliação da arborização urbana pelos residentes - estudo de caso em Mal. Cândido Rondon, Paraná.

    Directory of Open Access Journals (Sweden)

    Ubirajara Contro Malavasi

    2009-10-01

    Full Text Available Normal 0 21 MicrosoftInternetExplorer4 Este estudo objetivou quantificar a percepção da arborização urbana da cidade de Mal. Cândido Rondon, Paraná, pelos munícipes residentes. Os dados foram obtidos por meio da aplicação de um questionário a trinta residentes localizados em 53 pontos de amostragem da área urbana do município perfazendo um total de 1.590 entrevistas. Os resultados indicaram que, para 56% da população urbana, a cidade de Mal. Cândido Rondon, assim como a rua de residência do munícipe possuem alguma arborização. Dos entrevistados,  92 % percebem alguma vantagem da presença da arborização sendo que os benefícios  relacionados com o conforto térmico foram os mais lembrados. 75% dos entrevistados declararam sua colaboração na manutenção da arborização urbana. A valoração da arborização urbana pelos munícipes rondonenses refletiu-se no fato de que 91% dos entrevistados se declararem propensos a contribuir anualmente com valores entre R$ 1,00 e R$ 5,00 para a sua manutenção.

  10. AVALIAÇÃO DA ARBORIZAÇÃO URBANA PELOS RESIDENTES - ESTUDO DE CASO EM MAL. CÂNDIDO RONDON, PARANÁ

    Directory of Open Access Journals (Sweden)

    Ubirajara Contro Malavasi

    2001-03-01

    Full Text Available Este estudo objetivou quantificar a percepção da arborização urbana da cidade de Mal. Cândido Rondon, Paraná, pelos munícipes residentes. Os dados foram obtidos por meio da aplicação de um questionário a trinta residentes localizados em 53 pontos de amostragem da área urbana do município perfazendo um total de 1.590 entrevistas. Os resultados indicaram que, para 56% da população urbana, a cidade de Mal. Cândido Rondon, assim como a rua de residência do munícipe possuem alguma arborização. Dos entrevistados, 92 % percebem alguma vantagem da presença da arborização sendo que os benefícios relacionados com o conforto térmico foram os mais lembrados. 75% dos entrevistados declararam sua colaboração na manutenção da arborização urbana. A valoração da arborização urbana pelos munícipes rondonenses refletiu-se no fato de que 91% dos entrevistados se declararem propensos a contribuir anualmente com valores entre R$ 1,00 e R$ 5,00 para a sua manutenção.

  11. From Public to Private Sector: Motives and Explanations for Sector Switching

    DEFF Research Database (Denmark)

    Hansen, Jesper Rosenberg

    2014-01-01

    higher educated Danish employees who recently worked in the state, comparing those who shift job to another public organization with those who switch to the private sector. We focus on different motives for job shifts which may influence sector switching such as salary, job security, organizational......Sector switching is interesting in relation to understanding how to get and keep people working in the public sector as well as to understand public and private differences. This paper focuses on why public employees leave public organizations to work in the private sector. We use a design studying...

  12. Surto de malária induzida entre usuários de drogas injetáveis Outbreak of malaria among injectable-drug users

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Barradas Barata

    1993-02-01

    Full Text Available Em julho de 1990, foi registrado na cidade de Bauru, Estado de São Paulo, Brasil, um surto de malária envolvendo usuários de cocaína injetável. Uma ampla investigação epidemiológica, conduzida de 19 de julho a 13 de setembro, revelou que pelo menos 119 pessoas estavam envolvidas no surto, uma vez que haviam compartilhado seringas e agulhas com um ou mais casos confirmados nos 3 meses anteriores à ocorrência. Cento e duas dessas pessoas foram localizadas e entrevistadas, e destas, 99 foram submetidas a exame de gota espessa e 91 a exames sorológicos para malária. Foram confirmados por exame hemoscópico 21 casos de malária por P. vivax, e 3 outros tiveram exame sorológico positivo para P. vivax. O controle da transmissão foi obtido fornecendo-se cloroquina aos envolvidos no surto, numa dose inicial de 10 comprimidos, seguida de doses supressivas semanais de 2 comprimidos até que fosse identificado o último comunicante. Amostras de soro coletadas na ocasião revelaram, ao lado da malária, uma alta prevalência de infecções pelo HIV (58% e pelo vírus da hepatite B (40%. Foram discutidas as dificuldades para o controle do surto e a possibilidade da malária vir a se tornar uma doença endêmica entre usuários de drogas injetáveis, no Estado de São Paulo.Five cases of malaria were detected among cocaine users by the local health service in Bauru, a city with a population of 260,000, located 324 km from S. Paulo, Brazil, during the first three weeks of July 1990. Autochthonous malaria had not occurred in Bauru since 1978, and all the five cases denied having recently traveled to endemic areas. An extensive epidemiologic survey conducted from July 19 to September 13 revealed that the 5 cases were in fact part of a malaria outbreak among endovenous drug users. Moreover, at least 114 other people, who had in the last three months shared syringes and needles with one or more proved cases, were also involved in the outbreak. One

  13. Yeni Tesis Mandalina Bahçesinde Malç Tekstili Uygulamasının Yabancı Ot Kontrolü ve Mandalina Gelişimine Etkileri

    Directory of Open Access Journals (Sweden)

    Yasin Emre Kitiş

    2017-07-01

    Full Text Available Bu çalışma, malç tekstili adını verdiğimiz materyalin, yeni tesis edilen turunçgil bahçelerinde yabancı ot kontrolü amacıyla, konvansiyonel polietilen malç naylonu ve çiftçi koşullarında yaygın olarak uygulanan mekanik ve kimyasal mücadele ile kıyaslamalı olarak etkisinin belirlenmesi amacıyla doktora tez çalışmasının bir bölümü olarak yürütülmüştür. Yeni tesis mandalina bahçesinde üç yıl süreyle (2004-2005-2006 yürütülen çalışmada, iki farklı kalınlıkta polietilen malç, üç farklı kalınlıkta malç tekstili, biçme ve herbisit (glyphosate uygulamaları yapılmıştır. Uygulamaların yabancı otların yoğunluğu ve kaplama alanına, kültür bitkisinin boy, gövde kalınlığı ve yaprak alanına etkileri incelenmiştir. Çalışmanın sonuçları genel olarak değerlendirildiğinde, yabancı otlu kontrole oranla biçme uygulaması %23,4, kimyasal mücadele %88,4, polietilen malç %99,6, malç tekstili uygulamaları %100 oranında yabancı otları kontrol etmiştir. Kültür bitkisinin boyu, gövde çapı ve yaprak alanındaki en yüksek artış herbisit ve malç uygulamalarından elde edilmiştir. Malç uygulamalarının toprak sıcaklığı ve nemini muhafaza ettiği belirlenmiştir.

  14. Maltase protein of Ogataea (Hansenula) polymorpha is a counterpart to resurrected ancestor protein ancMALS of yeast maltases and isomaltases

    DEFF Research Database (Denmark)

    Viigand, Katrin; Visnapuu, Triinu; Mardo, Karin

    2016-01-01

    Saccharomyces cerevisiae maltases use maltose, maltulose, turanose and maltotriose as substrates, isomaltases use isomaltose, α-methylglucoside and palatinose and both use sucrose. These enzymes are hypothesized to have evolved from a promiscuous α-glucosidase ancMALS through duplication and muta......Saccharomyces cerevisiae maltases use maltose, maltulose, turanose and maltotriose as substrates, isomaltases use isomaltose, α-methylglucoside and palatinose and both use sucrose. These enzymes are hypothesized to have evolved from a promiscuous α-glucosidase ancMALS through duplication...

  15. Retardo no crescimento intrauterino, baixo peso ao nascer e prematuridade em recém-nascidos de grávidas com malária, na Colômbia

    Directory of Open Access Journals (Sweden)

    Alberto Tobón-Castaño

    2011-06-01

    Full Text Available INTRODUÇÃO: É frequente a associação da malária com complicações como prematuridade, retardo no crescimento intrauterino, baixo peso ao nascer e mortalidade infantil, efeitos pouco estudados em áreas hipoendêmicas para malaria. O objetivo deste estudo foi analisar a relação da malária gestacional com estes efeitos em recém-nascidosnuma região endêmica para malária na Colômbia, entre 1993 e 2007. MÉTODOS: Foram estudadas as características em 1.716 recém-nascidos num estudo de coorte. Fez-se seguimento em 394 gestantes com malária (27% por Plasmodium falciparum e 73% por P. vivax e 1.322 sem malária. RESULTADOS: Foi encontrada uma relação entre a exposição à malária na gestação e o risco maior de baixo peso ao nascer (RR = 1,37; 1,03-1,83, assim como estatura baixa (RR = 1,52; 1,25-1,85, retardo no crescimento intrauterino (RR = 1,29; 1,0-1,66 e prematuridade (RR = 1,68; 1,3-2,17. A frequência de nascimentos prematuros foi maior nas mães com malária por P. falciparum (77% que aquelas com P. vivax (RR = 1,77; IC 95%: 1,2-2,6. CONCLUSÕES: O baixo peso ao nascer e o retardo no crescimento foi associado com malária na gestação na Colômbia. A infecção por P. vivax foi relacionada com efeitos adversos sobre o recém-nascido, de modo semelhante em relação ao P. falciparum.

  16. Iran’s Pharmaceutical Sectoral Innovation System

    Directory of Open Access Journals (Sweden)

    Bahman Kargar Shahamat

    2017-12-01

    Full Text Available Abstract By reviewing economic performance, two main phenomena could be identified: The first phenomenon is prior to the third wave of the Industrial Revolution in which limited resources are the predominant input; in other words, physical and natural resources are much more credited than human resources. The second phenomenon resonates with the third wave of industrial revolution to the present time, suggesting the pivotal role of humans in production and accumulation of wealth, in which limited resources are no longer considered as predominant input. The present research seeks to understand the behavioral logic of the players of Iran's pharmaceutical sector so as to infer the innovative treatment of the firms in this sector. The concept of innovative system is indebted to the efforts economists and other scientists have made by analyzing economic development based upon technological development. Meanwhile, sectoral innovation system (SIS is a tool for analyzing a technological sector in the context of evolutionary economics with an emphasis on institutional capabilities. The structure of such an approach is composed of some components through which performance analysis of certain technological sector could be made possible. In research, we use expert panel with 12 experts from Universities, Companies, Governmental institutes. The current study wishes to explain structural model of institutional elements in this technological sector. Subsequently, in light of such an explanation, structural elements of this sector would be analyzed through identification of legal and regulatory framework, innovative culture, innovative infrastructure, financial resources, information resources, technology transfer mechanisms, commercialization support and marketing.

  17. Modelling energy demand of Croatian industry sector

    DEFF Research Database (Denmark)

    Medić, Zlatko Bačelić; Pukšec, Tomislav; Mathiesen, Brian Vad

    2014-01-01

    it is the third most energy intensive sector in Croatia after transport and households. Implementing mechanisms that would lead to improvements in energy efficiency in this sector seems relevant. Through this paper, long-term energy demand projections for Croatian industry will be shown. The central point......Industry represents one of the most interesting sectors when analysing Croatian final energy demand. Croatian industry represents 20% of nation's GDP and employs 25% of total labour force making it a significant subject for the economy. Today, with around 60 PJ of final energy demand...

  18. Construction sector development: frames and governance responses

    DEFF Research Database (Denmark)

    Jensen, Jens Stissing; Gottlieb, Stefan C.; Thuesen, Christian Langhoff

    2011-01-01

    The governance of construction sector development constitutes an important policy issue in many European countries due to the increasing impact that construction as well as the built environment have on gross domestic product and the environment. Previous studies have discussed how national...... activities may be governed. Based on a case study of the sector development activities in the Danish construction industry, this paper argues that governance strategies should not necessarily be designed to ensure the development of a single industrial conceptualization. First, drawing on concepts from...... composed of multiple incommensurable sector representations, then the most productive governance response may be to recognize and accept their conflicting strategic implications....

  19. Sector 7-8 powered up

    CERN Multimedia

    2007-01-01

    1. Frédéric Gicquel from the Cryogenics for Accelerators Group (AT/ACR) and Anupama Kulkarni from the Magnets and Electrical Systems Group (AT/MEL) at the CERN Control Centre during the powering-up of Sector 7-8. 2. Frédérick Bordry, leader of the Power Converter Group (AB/PO), and Roberto Saban, responsible for coordinating the LHC commissioning (TS/HDO), celebrate the end of the first powering-up of an entire LHC sector: Sector 7-8.

  20. Malaria infection and the anthropological evolution Infecção por Malária e evolução antropológica

    Directory of Open Access Journals (Sweden)

    Sergio Sabbatani

    2010-03-01

    malária exerceu papel biológico chave, influenciando até o desenvolvimento antropológico. Os Plasmódios causadores da malária desenvolveram dois tipos de evolução, segundo um ponto de vista biológico, e filogenético. Em particular, os Plasmódios vivax, malariae, e ovale poderiam ter coevoluído com a espécie humana ou ter atingido esta durante as fases mais antigas da evolução do gênero HOMO. Por outro lado, o Plasmódio falciparum teria sido transmitido aos humanos por macacos num período mais recente, provavelmente entre o fim da Idade Mesolítica e o início da Neolítica. Os Autores mostram evidências biomoleculares, tanto diretas como indiretas, de infecção por malária, observada em indivíduos enterrados, reportando ao Mundo Antigo, e trazidas à luz no decorrer de escavações arqueológicas em alguns sítios relevantes Mediterrâneos. Nesta revisão da literatura, os autores organizam evidências modernas. Confirmam o papel da malária ao afetar a evolução das populações no Mediterrâneo. As pessoas que moram nas várias regiões do Mediterrâneo foram progressivamente influenciadas pela malária, ao longo do avanço desta doença. Além disso, as populações afetadas desenvolveram adaptações culturais, alimentares, e de comportamento, contribuindo para uma redução no risco da doença. Entretanto, pode ser que ambas modificações (as biológicas e as dos hábitos usadas pelos Plasmódios da malária, favoreceram a emergência de grupos de pessoas com maior resistência contra a malária. Todos estes fatores considerados reduziram o impacto demográfico, influenciando de uma maneira favorável o desenvolvimento em geral, e o crescimento da civilização.

  1. 76 FR 57723 - Electricity Sector Cybersecurity Risk Management Process Guideline

    Science.gov (United States)

    2011-09-16

    ... Electricity Sector Cybersecurity Risk Management Process Guideline AGENCY: Department of Energy. ACTION... to publish the Electricity Sector Cybersecurity Risk Management Process Guideline. The guideline describes a risk management process that is targeted to the specific needs of electricity sector...

  2. Improving Outcomes in the Nigeria Healthcare Sector through Public ...

    African Journals Online (AJOL)

    PPP) model in the Country's healthcare sector. Public - Private Interaction offers opportunity of leveraging private sector investment in the sector and further enhances improvements in service delivery as well as increases access to quality ...

  3. 77 FR 21989 - Critical Infrastructure Private Sector Clearance Program Request

    Science.gov (United States)

    2012-04-12

    ... SECURITY Critical Infrastructure Private Sector Clearance Program Request AGENCY: National Protection and... information provided. SUPPLEMENTARY INFORMATION: The Critical Infrastructure Private Sector Clearance Program (PSCP) sponsors clearances for private sector partners who are responsible for critical infrastructure...

  4. Open Business Model Innovation in Healthcare Sector

    DEFF Research Database (Denmark)

    Lindgren, Peter; Rasmussen, Ole Horn; Poulsen, Helle

    2012-01-01

    The Open Innovation and Open Business Model Innovation (OBMI) approach (Chesbrough 2005, 2008) has been one of the most discussed innovation frameworks in the 2000s, and probably one of the most important contributions to business model innovations (BMIs) since 2005. Managers in the healthcare...... sector responsible for innovations have also tried to adapt the OBMI approach as a tool among the numerous other innovation tools. The aim of the paper is to present an initial study of the implementation of the framework of OBMI in the European healthcare sector. The study is naturally inspired...... from the European and US healthcare sectors. The paper focuses on the following research questions: • How can OBMI be defined? • How is OBMI used in the healthcare sector? The paper concludes by proposing a definition of open and close business models, and open and close business model innovations....

  5. Accelerator Sector - together we're stronger

    CERN Multimedia

    2002-01-01

    From 1 January onwards, the Accelerator Sector will be reorganised into two new divisions AB and AT. We talked to the leaders of these two divisions, Steve Myers and Philippe Lebrun, about this reorganisation.

  6. Modernize the Public Sector through Innovation?

    DEFF Research Database (Denmark)

    Hansson, Finn; Norn, Maria Theresa; Vad, Torben Bundgaard

    2014-01-01

    , this article presents the case of an evaluation of the Program on Research for Innovation and Renewal in the Public Sector (abbreviated FIFOS) under the Research Council of Norway. The evaluation described a number of problems in implementing new innovative knowledge, not only because of the organization....... Such an alternative strategy for producing and organizing the use of social science research to inform innovation in the public sector demands the rethinking of relevant evaluation models. In order to evaluate such a new approach, the article advocates new formative evaluation strategies, where learning and dialogue......The New Public Management drive to innovate in the public sector has become less influential and new initiatives to drive innovation are now sought. There are well-known challenges when using social science research to inform innovation in the public sector. In order to address these challenges...

  7. A Sectoral Analysis of Dividend Payment Behavior

    Directory of Open Access Journals (Sweden)

    Muhammad Nadeem Khan

    2017-01-01

    Full Text Available This study analyzes the sector-wise dividend payment behavior of Karachi Stock Exchange (KSE for the period 2009 through 2013. First, the trend of dividend payment of 5 years with respect to all 32 sectors is assessed through descriptive analysis. Second, the unit root test for panel data and pooled ordinary lest square (POLS test were used on 15 non-financial sectors. Results show that the earning per share has a positive impact on dividend payment in eight sectors including beverages, travel and leisure, fixed-line telecommunication, food processors, household goods, personal goods, automobiles, and electricity; however, forestry (paper and board is negatively associated with the dividend payout ratio. In addition, free cash flow has a positive impact on dividend payment in fixed-line telecommunication, and a negative impact on chemical, forestry, construction and material, engineering, beverages, tobacco, travel and leisure, food processor, household goods, pharmaceutical and biotech, and automobiles.

  8. Extended Higgs sectors in radiative neutrino models

    Directory of Open Access Journals (Sweden)

    Oleg Antipin

    2017-05-01

    Full Text Available Testable Higgs partners may be sought within the extensions of the SM Higgs sector aimed at generating neutrino masses at the loop level. We study a viability of extended Higgs sectors for two selected models of radiative neutrino masses: a one-loop mass model, providing the Higgs partner within a real triplet scalar representation, and a three-loop mass model, providing it within its two-Higgs-doublet sector. The Higgs sector in the one-loop model may remain stable and perturbative up to the Planck scale, whereas the three-loop model calls for a UV completion around 106 GeV. Additional vector-like lepton and exotic scalar fields, which are required to close one- and three-loop neutrino-mass diagrams, play a decisive role for the testability of the respective models. We constrain the parameter space of these models using LHC bounds on diboson resonances.

  9. Ruimtelijke gadgets in de agri-sector

    NARCIS (Netherlands)

    Jong, de S.M.; Bregt, A.K.

    2001-01-01

    Gekeken wordt naar een aantal technologische ontwikkelingen van de laatste jaren, zoals Global Positioning System, hoge resolutie satellietbeelden, beeldvormende spectrometers en low budget remote sensing, en hoe deze ontwikkelingen een weg vinden in de agri-sector, bijvoorbeeld binnen de

  10. Ship and Boat Building Sector (NAICS 3336)

    Science.gov (United States)

    Find environmental regulatory and compliance information for the shipbuilding sector (NAICS 3336), including NESHAPs and air toxics regulations, nonroad engines and vehicles, managing used oil, and polluted runoff from marinas and boating areas.

  11. Occupational Health Stress in the Service Sector

    National Research Council Canada - National Science Library

    Fozia Malik; Shaan Shahabuddin

    2015-01-01

      The basic purpose of the current study was to explore the occupational health stress reasons, consequences, and job outcomes in the service sector as well as to suggest stress management techniques to overcome stress...

  12. Climate Leadership in the Financial Sector Webinar

    Science.gov (United States)

    Financial sector winners from the 2015 Climate Leadership Awards discuss best practices and challenges faced by their corporations based on their experience of attempting to reduce greenhouse gas emissions and address climate risk.

  13. Automotive Sectors (NAICS 336, 4231, 8111)

    Science.gov (United States)

    Find regulatory, compliance, and enforcement information for environmental laws and regulations for the automotive sectors, which includes transportation equipment manufacturing, and establishments involved in repair and maintenance services for vehicles

  14. Market Report for the Industrial Sector, 2009

    Energy Technology Data Exchange (ETDEWEB)

    Sastri, Bhima [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States); Brueske, Sabine [Energetics Inc., Columbia, MD (United States); de los Reyes, Pamela [Energetics Inc., Columbia, MD (United States); Jamison, Keith [Energetics Inc., Columbia, MD (United States); Justiniano, Mauricio [Energetics Inc., Columbia, MD (United States); Margolis, Nancy [Energetics Inc., Columbia, MD (United States); Monfort, Joe [Energetics Inc., Columbia, MD (United States); Raghunathan, Anand [Energetics Inc., Columbia, MD (United States); Sabouni, Ridah [Energetics Inc., Columbia, MD (United States)

    2009-07-01

    This report provides an overview of trends in industrial-sector energy use. It focuses on some of the largest and most energy-intensive industrial subsectors and several emerging technologies that could transform key segments of industry.

  15. ARTIFICIAL INTELLIGENCE APPLICATIONS IN THE FINANCIAL SECTOR

    OpenAIRE

    Adrian Cozgarea; Gabriel Cozgarea; Andrei Stanciu

    2008-01-01

    The present paper exposes some of artificial intelligence specific technologies regarding financial sector. Through non-deterministic solutions and simple algorithms, artificial intelligence could become a base alternative for solving financial problems which require complex mathematic calculations or complex optimization.

  16. NAICS Sectors 31-33: Manufacturing

    Science.gov (United States)

    The Environmental Protection Agency (EPA) has many regulations that affect industries within the manufacturing sector. On those pages you can find a list of laws and regulations that affect your industry as well as compliance and enforcement information.

  17. The Public Sector Case for Marriage Equality

    National Research Council Canada - National Science Library

    Herrera, Dennis J

    2009-01-01

    .... Recommended Citation Herrera, Dennis J. (2009) "The Public Sector Case for Marriage Equality," California Journal of Politics and Policy: Vol. 1 : Iss. 1, Article 11. DOI: 10.2202/1944-4370.1019 Available at: http...

  18. Oil and Gas Extraction Sector (NAICS 211)

    Science.gov (United States)

    Environmental regulatory information for oil and gas extraction sectors, including oil and natural gas drilling. Includes information about NESHAPs for RICE and stationary combustion engines, and effluent guidelines for synthetic-based drilling fluids

  19. OptiMal-PK: an internet-based, user-friendly interface for the mathematical-based design of optimized anti-malarial treatment regimens.

    Science.gov (United States)

    Aljayyoussi, Ghaith; Kay, Katherine; Ward, Stephen A; Biagini, Giancarlo A

    2016-07-07

    The search for highly effective anti-malarial therapies has gathered pace and recent years have seen a number of promising single and combined therapies reach the late stages of development. A key drug development challenge is the need for early assessment of the clinical utility of new drug leads as it is often unclear for developers whether efforts should be focused on efficacy or metabolic stability/exposure or indeed whether the continuation of iterative QSAR (quantitative structure-activity and relationships) cycles of medicinal chemistry and biological testing will translate to improved clinical efficacy. Pharmacokinetic and pharmacodynamic (PK/PD)-based measurements available from in vitro studies can be used for such clinical predictions. However, these predictions often require bespoke mathematical PK/PD modelling expertise and are normally performed after candidate development and, therefore, not during the pre-clinical development phase when such decisions need to be made. An internet-based tool has been developed using STELLA(®) software. The tool simulates multiple differential equations that describe anti-malarial PK/PD relationships where the user can easily input PK/PD parameters. The tool utilizes a simple stop-light system to indicate the efficacy of each combination of parameters. This tool, called OptiMal-PK, additionally allows for the investigation of the effect of drug combinations with known or custom compounds. The results of simulations obtained from OptiMal-PK were compared to a previously published and validated mathematical model on which this tool is based. The tool has also been used to simulate the PK/PD relationship for a number of existing anti-malarial drugs in single or combined treatment. Simulations were predictive of the published clinical parasitological clearance activities for these existing therapies. OptiMal-PK is designed to be implemented by medicinal chemists and pharmacologists during the pre-clinical anti

  20. Nanotecnologia farmacêutica aplicada ao tratamento da malária Application of pharmaceutical nanotechnology to the treatment of malaria

    Directory of Open Access Journals (Sweden)

    Lúcio Figueira Pimentel

    2007-12-01

    Full Text Available Apesar do desenvolvimento tecnológico e científico, a malária permanece como um dos maiores problemas de saúde a serem combatidos. As estratégias modernas para o controle da doença prevêem ações conjuntas, como o combate do inseto vetor, diagnóstico rápido e preciso, garantia de terapêutica adequada, redução dos casos de resistência, além do desenvolvimento de novos agentes terapêuticos e vacina e através da otimização da ação de fármacos utilizados na atualidade. Os sistemas de liberação controlada de fármacos vêm recebendo atenção especial nesta área de pesquisa, com o desenvolvimento de estratégias para a veiculação de agentes bioativos e vacinas na forma de nanodispositivos tais como lipossomas, nanopartículas e micropartículas. Diversos nanossistemas já demonstraram eficácia na otimização de vacinas e quimioterápicos destinados ao controle da malária. Este artigo de revisão tem por objetivo avaliar o estado da arte na terapêutica da malária e demonstrar o potencial da nanotecnologia farmacêutica como ferramenta destinada ao combate da doença.In spite of living in a scientific and technological era, malaria continues to be one of the worldwide greatest health challenges. The state-of-the-art policy to keep malaria under control is expected to comprise joint-strategies, such as the vector control, fast diagnosis, therapeutic guarantee, resistance cutback, drug optimization and development of new therapeutic agents and vaccines. Nano and microcarrier systems have been receiving a special attention, including the development of strategies for carrying bioactive agents, vaccines through nanodevices, such as liposomes and nanoparticles, and microdevices, such as microparticles and microemulsions. Numerous nanosystems have already substantiated their effectiveness to optimize vaccines, insecticides, and chemotherapeutic agents applied to the control of malaria. This review is intended to explain the

  1. India's Downstream Petroleum Sector

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This study provides a holistic examination of pricing and investment dynamics in India's downstream petroleum sector. It analyses the current pricing practices, highlights the tremendous fiscal cost of current pricing and regulatory arrangements, and examines the sectoral investment dynamics. It also looks at potential paths towards market-based reform along which the Indian government may move, while at the same time protecting energy market access for India's large poor population.

  2. Efficiency of the Macedonian banking sector

    Directory of Open Access Journals (Sweden)

    Naumovska Elena

    2016-01-01

    Full Text Available The subject of this paper is to measure the efficiency of the Macedonian banking sector by applying two approaches: firstly, comparative analysis on the efficiency indicators of the banking sector in the Republic of Macedonia and the countries of Central and Southeastern Europe (CSEE and secondly, Data Envelopment Analysis (DEA. The aim is to provide directions and guidelines for further strengthening of the Macedonian banking sector. According to the comparative analysis of the efficiency indicators (net interest margin and operating costs of the Macedonian banking sector and the countries of CSEE, the countries whose banking sector shows lower operating costs are characterized with a higher level of financial deepening and greater degree of financial intermediation. The high interest margins direct towards unsuitable allocation of financial resources and insufficient competitiveness in the domestic banking sector. When applying the DEA approach, it can be stated that the group of large banks marks the highest efficiency within the Macedonian banking sector. The high concentration degree of banking activities within the group of large banks with a leading role in determining the interest rates, results in a rigid interest policy of the banks. In the direction of strengthening the efficiency of the Macedonian banking sector as a whole, the obtained results show that it is necessary for the banks to be further consolidated so as to utilize the advantages of the economies of scale, increase competitiveness, offer a diversified structure of products, invest in new contemporary software solutions that will allow reinforcement of their employees’ productivity and long-term reduction of the operating costs, as well.

  3. Facts 2010 - The Norwegian petroleum sector

    Energy Technology Data Exchange (ETDEWEB)

    2010-07-01

    The publication provides a general overview of information regarding the petroleum activities on the Norwegian continental shelf. Content; Foreword; The petroleum sector - Norway's largest industry; Organisation of Norwegian petroleum activity; Government petroleum revenues; Exploration activities; Development and operations; Norwegian gas exports; Decommissioning; Research, technology and industrial development; Environmental considerations in the Norwegian petroleum sector; Petroleum resources; Fields in production; Fields under development; Future developments; Fields where production has ceased; Pipelines and onshore facilities. (AG)

  4. Facts 2011 - The Norwegian petroleum sector

    Energy Technology Data Exchange (ETDEWEB)

    2011-07-15

    The publication provides a general overview of information regarding the petroleum activities on the Norwegian continental shelf. Content; Foreword; The petroleum sector - Norway's largest industry; Organisation of Norwegian petroleum activity; Government petroleum revenues; Exploration activities; Development and operations; Norwegian gas exports; Decommissioning; Research, technology and industrial development; Environmental considerations in the Norwegian petroleum sector; Petroleum resources; Fields in production; Fields under development; Future developments; Fields where production has ceased; Pipelines and onshore facilities. (AG)

  5. Mergers & Acquisitions in India: A sectoral analysis

    OpenAIRE

    Priya Bhalla

    2014-01-01

    Globalization, deregulation and technological improvements have resulted in increase in M&A across the globe. There is enormous literature existing in the advanced economies. However, very little information is available regarding M&A in India. Various sectors have witnessed differential involvement in M&A activity indicating higher participation by some. Particularly, certain sectors such as financial services and pharmaceuticals demonstrate higher M&A activity. To emphasise diff...

  6. Public Sector Marketing: Importance and Characteristics

    OpenAIRE

    Andreea Barbu

    2011-01-01

    Although marketing implementation within public services domain is considerable, and obstacles can often occur, the favorable consequences of the marketing reform in this sector are particularly important. The paper presents also the characteristics of marketing mix, and refers to the three levels of public sector, which requires implementation of marketing, giving rise to the three concepts: macro-marketing specific to central public administration (Government, ministries, agencies), micro-m...

  7. Financial sector support for small business development

    OpenAIRE

    2008-01-01

    The study examines the relationships between the financial sector and small businesses, and the small business policy framework in South Africa. The study also measures the perception of the Business Chambers and Commercial Banks on the effectiveness of financial sector support to small businesses in the Gauteng area through a questionnaire. The Small Business Development Policy of 1996 outlines the functions of various small business support institutions such as Ntsika Enterprise Promotion A...

  8. Sectorization and Configuration Transition in Airspace Design

    Directory of Open Access Journals (Sweden)

    Xiang Zou

    2016-01-01

    Full Text Available Current airspace is sectorized according to some predefined rules that are not flexible. To facilitate utilizing the airspace more efficiently, methods to design sectors need to be promoted. In this paper, we propose an undirected graph cut-based approach that employs a memetic local search-embedded constrained evolution algorithm, NSGA-II, to generate nondominated airspace configurations. We also propose a new concave hull-based method to automatically depict sector boundaries. In addition, we also study the configuration transition problem. We define the similarity of the two different configurations and calculate their similarity with a bisection diagram and a minimum cost flow algorithm. We build a forward network to represent configuration transitions across several consecutive time periods and use multiobjective dynamic programming to determine a series of nondominated configuration links from the first period to the end. We test our approaches by simulation in high-altitude airspace controlled by Beijing Area Control Center. The results show that our sectorization method outperforms the current configuration in practice, providing a lower sector number, lower intersector flow, more balanced workload distribution among the different sectors, and no constraint violations, so that the proposed approach shows its significant potential as practical applications for dynamic airspace configuration.

  9. Building recycling rates through the informal sector.

    Science.gov (United States)

    Wilson, David C; Araba, Adebisi O; Chinwah, Kaine; Cheeseman, Christopher R

    2009-02-01

    Many developing country cities aspire to modern waste management systems, which are associated with relatively high recycling rates of clean, source separated materials. Most already have informal sector recycling systems, which are driven solely by the revenues derived from selling recovered materials, even though they are saving the formal sector money by reducing waste quantities. There is clear potential for 'win-win' co-operation between the formal and informal sectors, as providing support to the informal sector, to build recycling rates and to address some of the social issues could reduce the overall costs of waste management for the formal sector. This paper shows that recycling rates already achieved by the informal sector can be quite high, typically in the range from 20% to 50%; often up to half of this is in the form of clean, source separated materials collected directly from households and businesses by itinerant waste buyers. Four country case studies provide a number of lessons on how this solid foundation could be used to build high recycling rates of clean materials.

  10. Neumonía por herpes virus simple tipo 1. Entidad infrecuente de difícil diagnóstico y mal pronóstico en trasplantados pulmonares

    Directory of Open Access Journals (Sweden)

    M.R. Mazzucco

    2014-04-01

    Debido a su baja frecuencia y mal pronóstico, es importante conocer y tener presente esta entidad en personas trasplantadas de pulmón para no demorar el diagnóstico y actuar lo más rápidamente posible.

  11. Sectoral dynamics and technological convergence: an evolutionary analysis of eco-innovation in the automotive sector

    DEFF Research Database (Denmark)

    Faria, Lourenco; Andersen, Maj Munch

    2017-01-01

    1965 to 2012, focusing on powertrain technologies. The empirical analysis is based on patent data amongst big car producers and focuses on identifying changes in two main aspects: (1) the convergence/divergence of firms’ green strategies and technologies within the automotive sector; and (2...... to understanding green industrial dynamics and the greening of the economy. This paper investigates to what degree the economy is greening horizontally (sector-wise). Starting with a sectoral case study, we undertake a longitudinal analysis of the breath and strength of the greening of the automotive sector from...

  12. Ecological Tax Reform with Exemptions for the Export Sector in a two Sector two Factor Model

    OpenAIRE

    Schleiniger, Reto

    1999-01-01

    This present paper analyzes an energy tax reform that exempts the energy-intensive export sector from paying the energy tax and uses the additional revenue to cut existing taxes in all sectors. To that end, a two sector two factor model of an open economy that is small on the import side but not on the export side is applied. Within this model, an equivalence between a tax reform with and without exemption of the export sector is derived. The equivalence occurs because in both tax schemes the...

  13. EL "MAL DE LAS VACAS LOCAS": UN TEMA DE BIOÉTICA EN LOS NUEVOS ESCENARIOS O "MAL DAS VACAS LOUCAS": UM TEMA DE BIOÉTICA NOS NOVOS CENÁRIOS THE "MAD COW DISEASE": A BIOETHICS’ ISSUE IN THE NEW SETTINGS

    Directory of Open Access Journals (Sweden)

    José Miguel Vera Lara

    2001-01-01

    Full Text Available La encefalopatía espongiforme bovina ("mal de las vacas locas", se produce en un momento y en un contexto que permiten resaltar los éxitos y fracasos de la biotecnología. En el marco de la globalización ha quedado de manifiesto la necesidad de establecer límites para la tecnociencia que en materia de logros aparecía como ilimitada. Se ha puesto en la balanza la rentabilidad de la industria cárnica versus la salud pública. El mal de las vacas locas constituye un traspié que no fue previsto, porque no era previsible en la perfectibilidad del sistema, lo que ha dejado al descubierto una fisura que, por ahora, es contextual. El contagio de las vacas a las personas es una campana de alarma, una advertencia que debe ser escuchada. La crisis esta recién en su etapa inicialA encefalopatia espongiforme bovina (mal da vaca louca ocorre em momento e contexto que permitem ressaltar êxitos e fracassos da biotecnologia. O marco da globalização tornou clara a necessidade de estabelecer limites para a tecnociência que por seus feitos mostrava-se ilimitada. Colocou-se na balança a rentabilidade da indústria da carne versus a saúde pública. O mal das vacas loucas constitui um deslize imprevisto, já que não era esperado considerando-se a perfeição do sistema e expos assim uma fissura que mostra-se contextual. O contágio de seres humanos é um alerta, uma advertência que deve ser considerada. A crise está apenas em sua etapa inicialBovine Spongiform Encephalopathy ("mad cow disease" appears in a moment and in a context that highlights the achievements and failures of biotechnology. The reality of globalization evidences the need to set limits to a technoscience viewed as unlimited because of its breakthroughs. Livestock industry profitability versus public health have been placed on the balance. Mad cow disease is an unforeseen stumble, since it was something unexpected in a system considered as perfect. This fact has disclosed a fissure

  14. Teste de hemaglutinação na sorologia da malária humana empregando hemácias parasitadas pelo Plasmodium berghei

    Directory of Open Access Journals (Sweden)

    Maria Carmen Arroyo Sanchez-Ruiz

    1985-06-01

    Full Text Available Foi padronizado um teste de hemaglutinação para a sorologia da malária humana, com reagente constituído de suspensão de hemácias de camundongos infectadas pelo Plasmodium berghei e preservadas por fixação aldeídica. Em pacientes com parasitemia por P. falciparum ou P. vivax obteve-se uma sensibilidade de 98,9% nos 88 casos estudados, o teste apresentando títulos entre 40 e 640. Para o grupo de 476 soros de indivíduos não-maláricos, obteve-se uma especificidade de 96,0%. O teste apresentou elevada reprodutibilidade, mesmo para diferentes lotes de antígenos. Nos 200 soros, obtidos ao acaso, de indivíduos de área endêmica, o teste apresentou positividade de 48,5%, contra 88,0% do teste de imunofluorescência-IgG. A baixa positividade pode ser devida a que o teste de hemaglutinação detecta anticorpos IgM. Após tratamento com 2-mercaptoetanol, todos os soros de pacientes com parasitemia tornaram-se não reagentes. Em relação ao teste de imunofluorescência-IgG, o teste de hemaglutinação apresentou índice de co-positívidade de 0,989 para os soros de maláricos com parasitemia. Para os soros de não-maláricos o teste de hemaglutinação apresentou índice de co-negatividade de 0,969. Por outro lado, no grupo de soros de área endêmica, o índice de co-positividade foi de 0,528 e o de co-negatividade, de 0,833.A hemagglutination test is described for human malaria serodiagnosis with aldehyde-fixed Plasmodium berghei infected mouse erythrocytes. In patients with a P. falciparum or P. vivax patent parasitemia positive results were seen in 98.9% ofthe 88 cases tested. Titres rangedfrom 40 to 640. A 96.0% specificity wasfoundfor 476 non-malarialpatients. A close reproducibility was observed forthe test, even for dijferent reagent batches. The test was positive in 48.5% of 200 residents in malaria endemic areas, taken at random. These subjects showed 88.0% positivity of the IgG-immunofluorescence test. This lower positivity for

  15. Lugares de memoria y lugares de amnesia. La familia como colectivo amnésico en Os libros arden mal de Manuel Rivas

    Directory of Open Access Journals (Sweden)

    Anna Lammers

    2016-07-01

    Full Text Available The expression “historical memory” is dominating the political, social and cultural discourse in Europe for the last few years. This term is essentially used in Spain where it is linked to the events of the Spanish Civil War (1936-1939 and the Dictatorship of Franco (1939-1975. Memories of these historical events never lose their need to be remembered. The work of the Galician author Manuel Rivas contributes to the rediscovery of these historical memories. His novel Os libros arden mal (2006 can be seen as a complex and versatile panorama of those traumatic events. This article focuses with references to the concepts of social and cultural studies about collective memory on representations of the Spanish Civil War and the Franco dictatorship in the above-mentioned novel of Manuel Rivas. Identifying the lieux de memoire of one of its protagonist families, it examines the role of the family as a space of transmission and remembrance

  16. Avaliação da arborização urbana pelos residentes – estudo de caso em mal. Cândido Rondon, Paraná

    Directory of Open Access Journals (Sweden)

    Ubirajara Contro Malavasi

    2001-01-01

    Full Text Available The study has had as its objective to evaluate resident perception and valorization of urban trees by residents of Mal. Cândido Rondon, Paraná. Date were collected from 1590 interviews, being selected 53 sample points with 30 residents in each point. Fifty six percent of the county urban residents classified the city, and their street of residency as reasonably forested. Meanwhile, 92 % indicated perceiving some advantages by the presence of urban trees. The most frequent advantages were related to environment amelioration. Ninety one percent of the responses indicated that residents would be willing to contribute with R$ 1,00 to R$ 5,00 annually in order to maintain urban trees.

  17. Mal de Hansen, anticorpos antifosfolípides e obstrução das artérias fibulares Leprosy, antiphospholipid antibodies and bilateral fibular arteries obstruction

    Directory of Open Access Journals (Sweden)

    Liz Wallin

    2009-04-01

    Full Text Available Pacientes com Mal de Hansen (MH podem se apresentar com quadro clínico e laboratorial sugestivo de doenças reumáticas, o que exige um exercício cuidadoso de diagnósticos diferenciais. Descreve-se aqui o caso de uma jovem com MH que se apresentou com lesões cutâneas sugestivas de vasculite, obstrução de vasos fibulares, FAN e anticorpos antifosfolípides positivos sem muitos estigmas da doença cutânea, ilustrando essa dificuldade.Patients with Hansen's disease (HD may present themselves with clinical and laboratorial features that resemble rheumatic disorders. This requires a careful exercise of differential diagnosis. We describe here a case of a young woman with HD that presented with vasculitic like lesions, fibular vessels obstruction, ANA and antiphospholipid antibodies without typical signs of cutaneous disease, illustrating this clinical difficulty.

  18. Mal de Pott en pediatría: presentación de 5 casos y revisión de la literatura

    OpenAIRE

    Gladys Abreu Suárez; José Antonio González Valdés; Ricardo Zamora Fuentes; Reyna Portuondo Leyva; Natacha Sandín Hernández; Aurelia Pérez

    2002-01-01

    Se presentan 5 de los 6 niños afectados de mal de Pott en el período de 1995 a 2001, para una incidencia del 4,5 % del total de casos de tuberculosis infantil en Cuba. La mayoría de los niños tenía alrededor de 2 años de edad, con un predominio de la afectación lumbar en 4 pacientes. El cuadro clínico fue insidioso, y fueron más frecuentes el dolor de espalda y los trastornos a la marcha. El diagnóstico fue clinicorradiológico, y la tuberculina positiva en 4 niños. Sólo se aisló Micobacterium...

  19. Causas mal definidas de morte e óbitos sem assistência Ill-defined causes of death and unattended deaths, Brazil, 2003

    Directory of Open Access Journals (Sweden)

    Augusto Hasiak Santo

    2008-02-01

    Full Text Available OBJETIVOS: Este trabalho estuda a distribuição dos óbitos por causas mal definidas no Brasil, no ano de 2003, entre as quais identifica a proporção de mortes sem assistência. MÉTODOS: Os dados provieram do Sistema de Informações Sobre Mortalidade, coordenado pelo Ministério da Saúde. As causas mal definidas de morte compreenderam as incluídas no "Capítulo XVIII - Sintomas, sinais e achados anormais de exames clínicos e de laboratório não classificados em outra parte" da Classificação Estatística Internacional de Doenças e Problemas Relacionados à Saúde, décima revisão, capítulo este no qual a categoria R98 identificava a "morte sem assistência". RESULTADOS: No Brasil, em 2003, a causa básica de 13,3% dos óbitos foi identificada como mal definida, sendo que as proporções maiores ocorreram nas Regiões Nordeste e Norte. Do total de causas mal definidas no país, 53,3% corresponderam a mortes sem assistência, proporção esta que superou 70% nos Estados do Maranhão, Piauí, Rio Grande do Norte, Pernambuco, Bahia, Paraíba e Alagoas. CONCLUSÃO: Dada a estrutura descentralizada para o levantamento dos óbitos no país, identifica-se a maior responsabilidade dos municípios e, em seguida, dos Estados para o aprimoramento da qualidade das estatísticas de mortalidade.BACKGROUND: We studied the distribution of deaths from ill-defined causes that occurred in Brazil during 2003, from which was identified the proportion of unattended deaths. METHODS: Data were obtained from the Mortality Information System, coordinated by the Ministry of Health. Causes of death included in "Chapter XVIII - Symptoms, signs and abnormal clinical and laboratory findings, not classified elsewhere" of the International Statistical Classification of Diseases and Related Health Problems, tenth revision, were considered ill-defined, among which the category R98 identified "unattended deaths". RESULTS: In Brazil during 2003 the underlying causes of

  20. Structural and photoluminescence properties of Dy3+ co-doped and Eu2+ activated MAl2O4 (M = Ba, Ca, Sr) nanophosphors

    Science.gov (United States)

    Dejene, F. B.; Kebede, M. A.; Redi-Abshiro, M.; Kgarebe, B. V.

    2013-09-01

    Long afterglow alkaline earth aluminates MAl2O4:Eu, Dy (M: Ca, Sr, Ba) phosphors are generally synthesized by the solid-state process which is more feasible than other conventional processes in terms of operation and large-scale production. However, the constituents of phosphors synthesized using this process are usually not mixed well, the particles agglomerates and very high temperature requirement to synthesize the final powder make it undesirable. In order to circumvent these problems, MAl2O4:Eu, Dy (Ca, Ba, Sr) phosphors were prepared at low temperatures (500 °C) by the solution-combustion of corresponding metal nitrate-urea solution mixtures, over a time of 5-10 min. In order to elucidate the relationship between the constituent, structure and PL properties product's particle size, morphological and structural properties were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive X-ray spectrometer (EDS), while the characteristic luminescence properties were investigated using emission spectra. The low temperature monoclinic structure for both CaAl2O4 and SrAl2O4 and the hexagonal structure of BaAl2O4 were observed. The emission spectra of these phosphors indicated that all of them are broad band, and the only emission peaks around 448, 490 and 515 nm of CaAl2O4:Eu, Dy, BaAl2O4:Eu, Dy and SrAl2O4:Eu, Dy, respectively, are due to 5d → 4f transition of Eu2+. The decay curves implied that these phosphors contain fast, medium and slow-decay process. The Dy3+ trap levels may be considered to be responsible for the long afterglow phosphorescence at room temperature.

  1. A evolução da mortalidade por causas mal definidas na população idosa em quatro capitais brasileiras, 1996-2007

    Directory of Open Access Journals (Sweden)

    Daisy Maria Xavier de Abreu

    2010-06-01

    Full Text Available Este artigo objetiva estudar a evolução da mortalidade por causas mal definidas na população com mais de 60 anos, residente em Belo Horizonte, Rio de Janeiro, São Paulo e Porto Alegre, entre 1996 e 2007. Foi analisada a evolução da mortalidade proporcional por causas mal definidas (CMD no período, a distribuição dessas mortes por grupos etários, segundo códigos do Capítulo XVIII da Classificação Internacional de Doenças - CID-10, e a posição desse grupo de causas no total de óbitos em idosos. Avaliou-se, também, a razão de chances (IC95% entre os óbitos por CMD e sua ocorrência em hospitais. A evolução da mortalidade proporcional por CMD nas capitais selecionadas, entre 1996 e 2007, indicou uma participação maior de óbitos por CMD em idosos no Rio de Janeiro, onde essas mortes ocupam a posição mais elevada (4º lugar na ordenação dos grupos de causas para a população idosa. Nessa capital também o percentual de óbitos por CMD ocorridos em hospitais foi quase o dobro das demais. Conforme esperado, a classificação da causa do óbito como CMD mostrou-se negativamente associada à ocorrência em hospitais. Os resultados evidenciam boa qualidade da informação, mas indicam problemas recorrentes na prestação da atenção médica à população idosa.

  2. Reposição cirúrgico-ortopédica de implante mal posicionado: relato de caso Surgical-orthopedic repositioning of malpositioned implant: a case report

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Ferreira da Silva

    2005-06-01

    Full Text Available A reabilitação bucal por meio da colocação de implantes dentários tem se tornado um procedimento freqüente da clínica odontológica. Falhas no planejamento ou na execução da técnica podem levar a casos onde, apesar de osseointegrado, o implante não apresenta condições de restauração satisfatória devido ao seu mal posicionamento. Diversos autores têm relatado a possibilidade de se utilizar osteotomias segmentares de maxila ou mandíbula para reposicionar um segmento alveolar com implante, mostrando que esta pode ser uma técnica efetiva e previsível para restaurar implantes em posição anatômica comprometida. O presente trabalho apresenta o caso clínico de uma paciente de 20 anos de idade onde foi realizada osteotomia segmentar de maxila associada à distração osteogênica para correção de um implante mal posicionado.Oral rehabilitation through dental implants has become a common procedure at dental practice. However, if the implant is placed in an inappropriate position either because of inadequate presurgical planning or poor surgical technique, it may be unrestorable in spite of osseointegrated. Many authors have reported the possibility of using segmental maxillary or mandibular osteotomies to reposition an alveolar segment with its implants. This can be an effective, predictable technique for restoring implants in a compromised anatomic position. This paper presents a case report describing the use of this procedure associated to distraction osteogeneis to reposition one malpositioned implant in a 20 years old girl.

  3. A randomized, multi-national, non-inferiority, phase III trial to evaluate the safety and efficacy of BF-200 ALA gel versus MAL cream in the treatment of non-aggressive basal cell carcinoma with photodynamic therapy (PDT).

    Science.gov (United States)

    Morton, C A; Dominicus, R; Radny, P; Dirschka, T; Hauschild, A; Reinhold, U; Aschoff, R; Ulrich, M; Keohane, S; Ekanayake-Bohlig, S; Ibbotson, S; Ostendorf, R; Berking, C; Gröne, D; Schulze, H J; Ockenfels, H M; Jasnoch, V; Kurzen, H; Sebastian, M; Stege, H; Staubach-Renz, P; Gupta, G; Hübinger, F; Ziabreva, I; Schmitz, B; Gertzmann, A; Lübbert, H; Szeimies, R-M

    2018-02-12

    Basal cell carcinoma (BCC) represents the most common non-melanoma skin cancer worldwide affecting mainly adult, fair-skinned individuals. The WHO distinguishes aggressive and non-aggressive forms of which prototypical variants of the latter are primary nodular and superficial BCC. To demonstrate non-inferiority of BF-200 ALA (a nanoemulsion gel containing 5-aminolaevulinic acid) compared to MAL (a cream containing methyl-aminolevulinate) in the treatment of non-aggressive BCC with photodynamic therapy (PDT). Non-inferiority of the primary efficacy variable (overall patient complete response 12 weeks after last PDT) would be declared if the mean response for BF-200 ALA was no worse than that for MAL, within a statistical margin of Δ = -15%. The study was a randomized, phase III trial performed in Germany and the UK with ongoing 5-year follow-up. Of 281 randomized patients, 138 were treated with BF-200 ALA, 143 with MAL. Patients received two PDT sessions one week apart. Remaining lesions 12 weeks after the second PDT were retreated. Illumination was performed with a red light source (635 nm, 37 J/cm 2 ). Results shown include clinical endpoints as well as patients' reassessment 12 months after the last PDT. Of the BF-200 ALA-treated patients, 93.4% were complete responders compared to 91.8% in the MAL group. The difference of means was 1.6 with a one-sided 97.5% CI of -6.5, establishing non-inferiority (pPDT is highly effective and well tolerated with proven non-inferiority to MAL-PDT and demonstrates low recurrence rates after 1-year follow-up. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  4. Private sector joins family planning effort.

    Science.gov (United States)

    1989-12-01

    Projects supported by the Directorate for Population (S&T/POP) of the U.S. Agency for International Development and aimed at increasing for-profit private sector involvement in providing family planning services and products are described. Making products commercially available through social-marketing partnerships with the commercial sector, USAID has saved $1.1 million in commodity costs from Brazil, Dominican Republic, Ecuador, Indonesia, and Peru. Active private sector involvement benefits companies, consumers, and donors through increased corporate profits, healthier employees, improved consumer access at lower cost, and the possibility of sustained family planning programs. Moreover, private, for-profit companies will be able to meet service demands over the next 20 years where traditional government and donor agency sources would fail. Using employee surveys and cost-benefit analyses to demonstrate expected financial and health benefits for businesses and work forces, S&T/POP's Technical Information on Population for the Private Sector (TIPPS) project encourages private companies in developing countries to invest in family planning and maternal/child health care for their employees. 36 companies in 9 countries have responded thus far, which examples provided from Peru and Zimbabwe. The Enterprise program's objectives are also to increase the involvement of for-profit companies in delivering family planning services, and to improve the efficiency and effectiveness of private volunteer organizations in providing services. Projects have been started with mines, factories, banks, insurance companies, and parastatals in 27 countries, with examples cited from Ghana and Indonesia. Finally, the Social Marketing for Change project (SOMARC) builds demand and distributes low-cost contraceptives through commercial channels especially to low-income audiences. Partnerships have been initiated with the private sector in 17 developing countries, with examples provided from

  5. Sectoral Systems and Innovation and Technology Policy

    Directory of Open Access Journals (Sweden)

    Franco Malerba

    2003-01-01

    Full Text Available Este artigo usa o conceito de sistema setorial de inovações que permite a utilização de uma visão multidimensional integrada e dinâmica da inovação em seus setores. Sistemas setoriais apresentam três dimensões que afetam tanto a geração e adoção de novas tecnologias quanto a organização da inovação e produção nos seguintes níveis setoriais: conhecimento, atores e redes e instituições. O artigo discute o escopo conceitual dos sistemas setoriais, apresenta cinco análises de setores principais e examina suas tendências principais, seus desafios e suas transformações. O artigo também oferece uma análise sobre implicações políticas públicas e sugestões do ponto de vista do sistema setorial de inovações.This paper uses the concept of sectoral system of innovation which aims to provide a multidimensional, integrated and dynamic view of innovation in sectors. Sectoral systems have three dimensions that affect the generation and adoption of new technologies and the organization of innovation and production at the sectoral level: knowledge (and the related boundaries, actors and networks, and institutions. The paper discusses the conceptual framework of sectoral systems, presents five main sectoral systems and examines their major trends, challenges and transformation. The paper then examines which are the main policy implications and indications in a sectoral system perspective.

  6. Transformation of the Polish Banking Sector

    Directory of Open Access Journals (Sweden)

    Marek Stefański

    2009-07-01

    Full Text Available In the post-war period the banking system in Poland underwent two important system transitions: after 1946 and after 1989. The third transformation began after May 1, 2004, but it did not have a systemic character. The Polish banking sector started to operate on the Single European Market. The first part of the paper is devoted to the problems of the banks transformations after 1989 with a special focus on the quantitative development of banks in 19892008, and on subsequent privatisation and consolidation processes. The former intensified in 19891999, and the latter in 19992002. The consolidation process was very noticeable in the sector of cooperative banks after 1994. The second part of the paper includes an economic and financial analysis of the banks. A lot of attention was paid to the liquidity of the banking sector. It was assessed as good, which was confirmed by a short-term rating of Moodys and by the Financial Stability Report 2009, published by the National Bank of Poland in June 2009. The comparison of the net profit of the banking sector in 19972008 shows its dependence on the economic situation and policy. The number of banks with capital adequacy ratio well above the minimum required by the banking supervision is rising. The financial power ratings are not favorable for the domestic banks. The third part of the paper focuses on the development directions of the Polish banking sector. It may be concluded on the basis of the analysis that privatisation and consolidation processes will be continued. They will concentrate on the capital of foreign banks already operating in Poland. As compared with individual foreign banks, the potential of the Polish banking sector is week. The fourth part of the paper focuses on the presentation Polish banking sector in the context of European Union banking sector. The paper finishes with conclusions. Generally, Polish banks have to implement a strategy to enable them to compete on the Single

  7. Lepton mixing from the hidden sector

    Science.gov (United States)

    Ludl, P. O.; Smirnov, A. Yu.

    2015-10-01

    Experimental results indicate a possible relation between the lepton and quark mixing matrices of the form UPMNS≈VCKM†UX , where UX is a matrix with special structure related to the mechanism of neutrino mass generation. We propose a framework which can realize such a relation. The main ingredients of the framework are the double seesaw mechanism, SO(10) grand unification and a hidden sector of theory. The latter is composed of singlets (fermions and bosons) of the grand unified theory (GUT) symmetry with masses between the GUT and Planck scale. The interactions in this sector obey certain symmetries Ghidden. We explore the conditions under which symmetries Ghidden can produce flavor structures in the visible sector. Here the key elements are the basis-fixing symmetry and mediators which communicate information about properties of the hidden sector to the visible one. The interplay of SO(10) symmetry, basis-fixing symmetry identified as Z2×Z2 and Ghidden can lead to the required form of UX. A different kind of new physics is responsible for generation of the CKM mixing. We present the simplest realizations of the framework which differ by nature of the mediators and by symmetries of the hidden sector.

  8. Building a Cross-sectoral, Multi-sectoral, Gender-sensitive Approach ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Building a Cross-sectoral, Multi-sectoral, Gender-sensitive Approach to Violence Against Women. It is generally believed that women in northeastern India enjoy greater mobility and visibility than women in the rest of the country. Nevertheless, customary practices in the region make women and girls vulnerable to violence ...

  9. Formal sector subcontracting and informal sector employment in Indian manufacturing : Author

    NARCIS (Netherlands)

    Moreno-Monroy, Ana I; Pieters, Janneke; Erumban, Abdul Azeez

    2014-01-01

    Using nationally representative survey data of Indian manufacturing enterprises spanning the period 1995–2006, we analyze the link between formal sector subcontracting and informal sector employment. A novelty in our analysis is that this relationship is allowed to differ between modern and

  10. Business opportunities in the Ethiopian fruit and vegetable sector

    NARCIS (Netherlands)

    Wiersinga, R.C.; Jager, de A.

    2009-01-01

    The horticultural sector in Ethiopia is growing strongly. Major part of this growth is created by investments in the floriculture sector. Recently more and more in terest from the Dutch private sector is shown in the Ethiopian fruits and vegeta ble sector. Export of fruit and vegetables has been

  11. Business opportunities in the Ethiopian fruit and vegetable sector

    NARCIS (Netherlands)

    Wiersinga, R.C.; Jager, de A.

    2009-01-01

    The horticultural sector in Ethiopia is growing strongly. Major part of this growth is created by investments in the floriculture sector. Recently more and more interest from the Dutch private sector is shown in the Ethiopian fruits and vegetable sector. Export of fruit and vegetables has been

  12. Economic Multipliers and Sectoral Linkages: Ghana and the New Oil Sector

    Directory of Open Access Journals (Sweden)

    Dennis Nchor

    2016-01-01

    Full Text Available The study seeks to assess the structure of the economy of Ghana in terms of changes in the economic structure before and after the production of oil in commercial quantities. This is viewed with regards to economic multipliers, sectoral interdependence and trade concentration. The results show that changes occurred with regards to multipliers and sectoral interdependence. The output multipliers of most sectors have declined. The results also show that the agricultural sector experienced an initial decline in its growth while industry experienced an increase. The performance of the services sector was relatively stable for the period covered by the study. There is a decline in the level of trade concentration though on a whole the concentration index is still high. The study employed input-output modeling techniques and the data was obtained from the Ghana statistical service and the World Development Indicators.

  13. Strategic Environmental Assessment & The Danish Energy Sector

    DEFF Research Database (Denmark)

    Lyhne, Ivar

    . - Empirical cases reveal how strategic decision-making in the sector is characterised by an extensive interaction between policy-making and planning in a highly dynamic context. - The outlined characteristics challenge the application of SEA especially in terms of timing and flexibility. SEA practice is still......"Strategic Environmental Assessment and the Danish Energy Sector" is a doctoral thesis based on a Ph.D. project with the same title. The overall aim of the project has been to assist actors in the energy sector in developing a meaningful way of applying SEA at strategic level. Understanding of how...... strategic decisions are made is a prerequisite for achieving this target, and the thesis therefore explores the strategic decision-making processes of contemporary energy infrastructure developments. The highlights of this thesis are: - A combination of disciplines in a continuum of perspectives...

  14. Nanofocusing in circular sector-like nanoantennas

    DEFF Research Database (Denmark)

    Zenin, Volodymyr; Pors, Anders Lambertus; Han, Zhanghua

    2014-01-01

    a concentric circular line of phase contrast, demonstrating resonant excitation of a standing wave of counter-propagating surface plasmons, travelling between a tip and opposite circular edge of the antenna. Transmission spectra obtained in the range 900 - 2100 nm are in good agreement with numerical......Gold circular sector-like nanoantennas (with a radius of 500 nm and a taper angle of 60°, 90°, and 120°) on glass are investigated in a near-infrared wavelength range (900 - 2100 nm). Amplitude- and phase-resolved near-field images of circular sector-like antenna modes at telecom wavelength feature...... simulations, revealing the main feature of this antenna configuration, viz., the resonance wavelength, in contrast to triangular antennas, does not depend on the taper angle and is determined only by the sector radius. This feature together with a robust and easily predictable frequency response makes...

  15. Sectoral and regional expansion of emissions trading

    Energy Technology Data Exchange (ETDEWEB)

    Boehringer, Christoph; Bouwe, Dijkstra; Rosendahl, Knut Einar

    2011-07-01

    We consider an international emissions trading scheme with partial sectoral and regional coverage. Sectoral and regional expansion of the trading scheme is beneficial in aggregate, but not necessarily for individual countries. We simulate international CO{sub 2} emission quota markets using marginal abatement cost functions and the Copenhagen 2020 climate policy targets for selected countries that strategically allocate emissions in a bid to manipulate the quota price. Quota exporters and importers generally have conflicting interests about admitting more countries to the trading coalition, and our results indicate that some countries may lose substantially when the coalition expands in terms of new countries. For a given coalition, expanding sectoral coverage makes most countries better off, but some countries (notably the USA and Russia) may lose out due to loss of strategic advantages. In general, exporters tend to have stronger strategic power than importers.(Author)

  16. When do ruling elites support productive sectors?

    DEFF Research Database (Denmark)

    Kjær, Anne Mette

    that the ruling elite initially supported the fishing industry because of industry pressure. They have failed to enforce fisheries management because there are big political costs associated with such enforcement. The dairy sector in the southwestern milk region was initially supported because the ruling elite...... wanted to build a coalition of support in this region. Coming from the region himself, the president had a keen interest in dairy cattle. The sector was subsequently regulated because the biggest processor put pressure on the ruling elite to do so. Even when the ruling coalition is fragmented, promoting...... production is possible if there is strong industry pressure and when the initiatives to promote the sector are also seen to help build or maintain the ruling coalition....

  17. Reregulation of the Swedish pharmacy sector

    DEFF Research Database (Denmark)

    Wisell, Kristin; Winblad, Ulrika; Sporrong, Sofia Kälvemark

    2015-01-01

    In 2009, a reregulation of the Swedish pharmacy sector took place, and a fundamental change in ownership and structure followed. The reregulation provides an opportunity to reveal the politicians' views on pharmacies. The aim of this study was to explore and analyze the political arguments...... for the reregulation of the Swedish pharmacy sector in 2009. The method used was a qualitative content analysis of written political documents regarding the reregulation. The primary rationales for the reregulation were better availability, efficiency, price pressure, and safe usage of medicines. During...... are better equipped to perform public activities. The results point to that the reform was done almost solely in order to introduce private ownership in the pharmacy sector, and was not initiated in order to solve any general problems, or to enhance patient outcomes of medicine use....

  18. Sectoral Approaches to Greenhouse Gas Mitigation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This paper explores sectoral approaches as a new set of options to enhance the effectiveness of greenhouse gas reduction policies and to engage emerging economies on a lower emission path. It surveys existing literature and recent policy trends in international climate change discussions, and provides an overview of sectoral approaches and related issues for trade-exposed, greenhouse-gas intensive industries (cement, iron and steel and aluminium). It is also based on interviews conducted by the IEA Secretariat in Australia, China, Europe, Japan, and the United States. Sectoral approaches were also discussed during workshops on technology and energy efficiency policies in industry, following the IEA's mandate under the Gleneagles Plan of Action.

  19. Strategy in the Public and Private Sectors

    DEFF Research Database (Denmark)

    Alford, John; Greve, Carsten

    2017-01-01

    Strategic concepts and practices first evolved in the private sector, so they evoked much controversy when they migrated to the public sector from the late 1970s onwards. Partly this was about their (in)applicability to the distinctive features of government organizations, in particular their focus....... These and other factors complicated efforts to apply New Public Management and similar frameworks in strategy concepts in a governmental context. Partly also the traditional private-sector focus on single organizations did not resonate with the growth of network governance from the 1990s. The authors argue...... for an alternative model based primarily on the public value framework as a means of incorporating and going beyond traditional strategy thinking....

  20. Development of Agrotouristical Sector in Romania

    Directory of Open Access Journals (Sweden)

    Irina Elena CHIRTOC

    2016-09-01

    Full Text Available The agrotouristical sector allows demand to space by engaging in recreational activities, sports and cultural entertainment, respond to the urban population growing interest towards the natural heritage and rural culture, having important implications in terms of economic and socio-political life of the Romanian village. The paper provides a brief analysis of the sector of agro-tourism in our country during 2000-2015, using the statistics presented by the National Institute of Statistics, to the eight regions level, namely: North West, Central, North East, South East, South-Muntenia, Bucharest-Ilfov, South West and West Oltenia.

  1. PRODUCTIVITY IN THE FINANCIAL ALUMINUM SECTOR COMPANIES

    Directory of Open Access Journals (Sweden)

    José G. Macías B.

    2013-07-01

    Full Text Available The objective of the research was to analyze productivity in the financial management of the basic industries sector in the Guayana Region aluminum. The methodology used was the structural equation model, using Lisrel 8.80 software, designing a model of productivity based on the anticipation and prediction for management processes. The results show a correlation coefficient of 96% for the variable productivity, which proves that the model can be used to manage financial management identifying opportunities for reducing losses and allowing raising the competitive position of companies in the sector.

  2. Supporting innovation in the food sector

    DEFF Research Database (Denmark)

    Grunert, Klaus G.

    2006-01-01

    A major aim for our research is to contribute to the continued innovativeness of the Danish and European food sectors. Innovation is the key to future competitiveness - and a major task for research is to provide the foundations for innovativeness in the food chain.......A major aim for our research is to contribute to the continued innovativeness of the Danish and European food sectors. Innovation is the key to future competitiveness - and a major task for research is to provide the foundations for innovativeness in the food chain....

  3. Practice Variation in Public Sector Internal Auditing

    DEFF Research Database (Denmark)

    Arena, Marika; Jeppesen, Kim Klarskov

    2016-01-01

    This article aims to analyze the rise of practice variations in public sector internal auditing (IA), giving special attention to the role of agents’ embeddedness in multiple institutional arrangements. IA's trends of development and the characteristics of the public sector context, in fact, make...... IA inherently subject to multiple institutional forces that interact with the system of values and beliefs of individual internal auditors. The empirical analysis, which relies on case study methodology, highlights the inherent tensions associated with the changing role of IA and shows how different...

  4. Atomki anomaly and the Secluded Dark Sector

    OpenAIRE

    Yamamoto, Yasuhiro

    2017-01-01

    The Atomiki anomaly can be interpreted as a new light vector boson. If such a new particle exists, it could be a mediator between the Standard Model sector and the dark sector including the dark matter. We discussed some simple effective models with these particles. In the models, the secluded dark matter models are good candidates to satisfy the thermal relic abundance. In particular, we found that the dark matter self-interaction can be large enough to solve the small scale structure puzzle...

  5. Germany; Technical Note on Banking Sector Structure

    OpenAIRE

    International Monetary Fund

    2011-01-01

    This Technical Note focuses on banking sector structure in Germany. Germany’s banking system comprises three “pillars†—private commercial banks, public sector banks, and cooperative banks—distinguished by the ownership structure and business orientation. The German banking system includes a large number of institutions in both absolute and relative terms. This note describes the evolution of Germany’s three-pillar banking system. It analyzes capitalization, credit and the intermed...

  6. Scenario’s voor effectief leren op de werkplek; Sector Economie en Sector Techniek; Workshop 5: Opstarten

    NARCIS (Netherlands)

    Mazereeuw, Marco; McKenney, Susan; Wopereis, Iwan

    2013-01-01

    Mazereeuw, M., McKenney, S., & Wopereis, I. (2013, 26 September). Scenario’s voor effectief leren op de werkplek; Sector Economie en Sector Techniek; Workshop 5: Opstarten [Scenarios for effective workplace learning; Sector Economics and Sector Engineering; Workshop 5: Start up]. Workshop presented

  7. Private sector outlook: will the private sector develop existing and new conservation technologies in a timely fashion on its own

    Energy Technology Data Exchange (ETDEWEB)

    1979-01-01

    Decisions and arguments made by the private sector on energy conservation investment and research and development (R and D) are discussed. Arguments (applicable to the industrial intermediate goods sector, to appliances, to community systems, and to the transportation sector) as to whether the private sector would allocate as much funding to energy conservation R and D as would be socially desirable are outlined. (MCW)

  8. Infrastructure protection in the Dutch financial sector

    NARCIS (Netherlands)

    van Oers, M.H.M.; Strous, L.; Berndsen, R.J.; Butts, J.; Shenoi, S.

    2012-01-01

    This paper presents a case study of critical infrastructure protection in the Dutch financial sector. The organizational structures are examined to discern the roles and functions that facilitate public-private cooperation. An assessment of the organizational structures is provided along with a

  9. Climate Change Adaptation in the Water Sector

    NARCIS (Netherlands)

    Ludwig, F.; Kabat, P.; Schaik, van H.; Valk, van der M.

    2009-01-01

    Today’s climate variability already has a large impact on water supply and protection. Millions of people are affected every year by droughts and floods. Future climate change is likely to make things worse. Many people within the water sector are aware that climate change is affecting water

  10. The importance of measuring household sector innovation

    NARCIS (Netherlands)

    de Jong, J.P.J.

    Empirical evidence shows that consumers can innovate as well as producers They spend considerable time and money and collaboratively develop substantial projects, which enhance social welfare. Household sector innovation is also important in developing countries. We summarize recent insights on how

  11. Information Technology Sector Baseline Risk Assessment

    Science.gov (United States)

    2009-08-01

    Technology Sector Baseline Risk Assessment extended periods could result in communications disruptions or congestion , if...function. Concern Threats to BGP and other interdomain router operating systems and intra-domain protocols are the primary vulnerabilities within the...facilities [C] Negatively affect ASN/IP block allocation [C] Impair Crisis response [C] Interdomain /Backbone connectivity impact [V] BGP [V

  12. Participation and Sector Selection in Nicaragua

    DEFF Research Database (Denmark)

    Pozzoli, Dario; Ranzani, Marco

    is estimated: it allows understanding that age is mainly a supply side factor, while education is an important element determining employers' choice. Information networks, captured by the presence of a household member working in the formal sector, and geographical barriers to mobility also play a leading role....

  13. IT-induced public sector transformation

    NARCIS (Netherlands)

    Van Veenstra, A.F.E.

    2012-01-01

    IT-induced public sector transformation investigates the organizational changes that are undertaken to transform public administrations using information technology (IT). While IT made governments more efficient, it is unclear whether it will also make them more effective in creating public value

  14. Sustainable development in Cameroon's forestry sector: Progress ...

    African Journals Online (AJOL)

    EJIRO

    This paper examines initiatives formulated by the government of Cameroon to promote sustainable development within its forestry sector, and proffers a series of policy recommendations for advancing sustainable forest management in Cameroon. Since the enactment of Cameroon's comprehensive forestry law (Law N0.

  15. Rights of access to public sector information

    NARCIS (Netherlands)

    van Eechoud, M.; Janssen, K.

    2012-01-01

    The reliance on national access norms is an important feature of the EU’s re-use framework. It impacts the kinds of policy choices that can be expected to be effective in stimulating commercial and non-commercial re-use of public sector information by private actors (businesses, civil society

  16. Malaysian water sector reform : policy and performance

    NARCIS (Netherlands)

    Kim, C.T.

    2012-01-01

    One of the measures that can help developing countries in meeting Target 10 of the Millennium  Development Goals – halving the number of people without access to water and adequate sanitation  by 2015 – is through a water sector reform. In this research the Malaysian water

  17. editorial harmony in nigerian health sector

    African Journals Online (AJOL)

    HENRY

    Everyone in a team is important and how well one does his work is crucial to the overall success of the team. There should be mutual respect for each member of the health team. No one should want any right that he is not ready to also fulfil its inalienable responsibility. Finally, the health sector is supposed to be where ...

  18. Economic growth, sectoral structure and unemployment

    NARCIS (Netherlands)

    de Groot, H.L.F.

    1998-01-01

    This thesis consists of three parts that deal with the relationship between the relative wealth of nations, economic growth, and the sectoral structure of economies. In the first part, the focus is on the relative stagnancy of Europe versus the USA in terms of productivity levels and unemployment.

  19. Rethinking Information Systems in the Public Sector

    DEFF Research Database (Denmark)

    Medaglia, Rony

    2014-01-01

    This section of Information Polity consists of papers presented during the workshop “Rethinking Information Systems in the Public Sector: Bridging Academia and Public Service”. The workshop was held on 8 June 2014 in Tel Aviv, Israel, in conjunction with the European Conference on Information...

  20. Private sector development | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2010-12-21

    Dec 21, 2010 ... From its own practical support for private sector development, IDRC has learned that two kinds of assistance can pay dividends: improving the business environment, and stimulating innovation. If donor agencies work to enhance the general environment for business — for example, by pressing for reforms ...

  1. Corruption, Trust and their Public Sector Consequences

    DEFF Research Database (Denmark)

    Fritzen, Scott A.; Serritzlew, Søren; Svendsen, Gert Tinggaard

    2014-01-01

    Corruption and trust are two important determinants of the quality of public sectors. Empirical studies in different literatures suggest that corruption and trust have effects on factors such as economic growth, the quality of democratic institutions, life quality, the size and effectiveness of t...

  2. Risk sectors for undesirable behaviour and mobbing

    NARCIS (Netherlands)

    Hubert, A.B.; Veldhoven, M.J.P.M. van

    2001-01-01

    The aim of this short note was to get an impression of risk sectors for the prevalence of undesirable behaviour and mobbing in The Netherlands. Data were collected from 1995 to 1999 with the Questionnaire on The Assessment and Experience of Work (Vragenlijst Beleving en Beoordeling van de Arbeid;

  3. Higher Education--The Flexible Employment Sector?

    Science.gov (United States)

    Scott, Jill; Ridgley, Clare; Spurgeon, Peter

    2003-01-01

    Explored the extent to which policies and practices promoting work-life balance (family friendly policies) have been taken up within the English higher education sector. Responses from 50 higher education institutions show that flexible working practices are more widespread than the formal policies of institutions would suggest. (SLD)

  4. Exploring a hidden fermionic dark sector

    Indian Academy of Sciences (India)

    2017-10-09

    Oct 9, 2017 ... ... global U ( 1 ) H charge while the gauge bosons and dark scalar do not have any global U ( 1 ) H charge. The lightest fermion in dark sector can serve as a potential dark matter candidate. We investigate whether the proposed dark matter candidate can explain indirect detection results from galactic centre.

  5. Corporate Social Responsibility in the Water Sector

    DEFF Research Database (Denmark)

    Lauesen, Linne Marie

    of these water companies. The findings of the study suggest a new definition of a colonising logic of CSR competing and coexisting with the regulators’ colonising logic of NPM. Through the study and definition of these logics as colonising the water sector this PhD theisis provides an understand of new...

  6. The Bamble Sector, South Norway: A review

    Directory of Open Access Journals (Sweden)

    Timo G. Nijland

    2014-09-01

    Full Text Available The Proterozoic Bamble Sector, South Norway, is one of the world's classic amphibolite- to granulite-facies transition zones. It is characterized by a well-developed isograd sequence, with isolated ‘granulite-facies islands’ in the amphibolite-facies portion of the transition zone. The area is notable for the discovery of CO2-dominated fluid inclusions in the granulite-facies rocks by Jacques Touret in the late 1960's, which triggered discussion of the role of carbonic fluids during granulite genesis. The aim of this review is to provide an overview of the current state of knowledge of the Bamble Sector, with an emphasis on the Arendal-Froland-Nelaug-Tvedestrand area and off shore islands (most prominantly Tromøy and Hisøy where the transition zone is best developed. After a brief overview of the history of geological research and mining in the area, aspects of sedimentary, metamorphic and magmatic petrology of the Bamble Sector are discussed, including the role of fluids. Issues relevant to current geotectonic models for SW Scandinavia, directly related to the Bamble Sector, are discussed at the end of the review.

  7. Behavioral economics and the public sector

    NARCIS (Netherlands)

    Weber, M.G.

    2015-01-01

    This thesis consists of four essays dealing with topics that are relevant for the public sector. The essays cover diverse issues of economics partly overlapping with political science. The topics reach from the taxation of labor over monetary policy to preferences over voting institutions.

  8. [Organization and technology in the catering sector].

    Science.gov (United States)

    Tinarelli, Arnaldo

    2014-01-01

    The catering industry is a service characterized by a contract between customer and supplier. In institutional catering industry, the customer is represented by public administration; in private catering industry, the customer is represented by privates. The annual catering trades size is about 6.74 billions of euros, equally distributed between health sector (hospitals, nursing homes), school sector and business sector (ivorkplace food service), with the participation of nearly 1.200 firms and 70.000 workers. Major services include off-premises catering (food prepared away from the location where it's served) and on-premises catering (meals prepared and served at the same place). Several tools and machineries are used during both warehousing and food refrigerating operations, and during preparation, cooking, packaging and transport of meals. In this sector, injuries, rarely resulting serious or deadly, show a downward trend in the last years. On the contrary, the number of occupational diseases shows an upward trend. About the near future, the firms should become global outsourcer, able to provide other services as cleaning, transport and maintenance. In addition, they should invest in innovation: from tools and machineries technology to work organization; from factory lay-out to safely and health in the workplaces.

  9. Evidence from the South African banking sector.

    African Journals Online (AJOL)

    panel data analysis techniques compared to cross-sectional analysis. In the con- text of South African banking sector, with high concentration rates, a system that proved resilience to the 2008/09 global financial crisis and a sophisticated financial market, we thus hypothesise that there is a statistically positive associ-.

  10. Marketing in the Australian Higher Education Sector

    Science.gov (United States)

    Favaloro, Chrissa

    2015-01-01

    This article examines domestic marketing in the Australian higher education sector, specifically, the marketing investment patterns of universities and their levels of student growth as a return on marketing investment. Marketing expenditure by universities has risen 23 per cent in the five years to 2013, with several institutions allocating in…

  11. Africa's Mining Sector Development: An Industry Perspective ...

    African Journals Online (AJOL)

    Africa has in the past decade benefited from continuously increasing investment in the mining sector and is becoming a fully-fledged player in the world economy as a result of the mining boom. Growth in demand for mineral resources coming from emerging countries has transformed Africa, which previously received little ...

  12. HEALTH SECTOR ACTIONS TO IMPROVE NUTRITION ...

    African Journals Online (AJOL)

    Reducing malnutrition-related maternal and childhood morbidity and mortality in Africa requires a systematic and coordinated strategy. This paper discusses a health sector strategy which includes: i) advocating for action in nutrition at all levels; ii) integration of the essential nutrition actions into six key contact points ...

  13. Voetafdruk wijst biologische sector de weg

    NARCIS (Netherlands)

    Sukkel, W.

    2009-01-01

    Biologische producten hebben een milieuvriendelijk imago. Maar dat is niet terecht als je een onbespoten kiwi laat invliegen uit Nieuw-Zeeland. Wijnand Sukkel van Praktijkonderzoek Plant en Omgeving onderzoekt of het berekenen van voedselkilometers en koolstofvoetafdrukken de sector kan helpen om

  14. The Bamble Sector, South Norway: A review

    NARCIS (Netherlands)

    Nijland, T.G.; Harlov, D.E.; Andersen, T.

    2014-01-01

    The Proterozoic Bamble Sector, South Norway, is one of the world’s classic amphibolite- to granulitefacies transition zones. It is characterized by a well-developed isograd sequence, with isolated ‘granulite-facies islands’ in the amphibolite-facies portion of the transition zone. The area is

  15. Enhancing Parliamentary Oversight for Effective Security Sector ...

    African Journals Online (AJOL)

    2015-06-09

    Jun 9, 2015 ... security forces continued to serve the interests of the ruling elites rather than the security requirement of the people (Bendix .... Benjamin Adeniran Aluko. Enhancing Parliamentary Oversight for Effective Security Sector Reform in Democratic Nigeria. 4. Accountability;. 5. Public trust;. 6. Local ownership;. 7.

  16. Merger and Acquisition in the Banking Sector

    Directory of Open Access Journals (Sweden)

    Anna Szewczyk

    2008-10-01

    Full Text Available The article presents situation on mergers and acquisitions (MA in banking sector during last twenty years. The main motives are selected and analyzed. All is explained on the base on research reports of the Deutsche Bundesbank and the European Central Bank.

  17. The Performance Paradox in the Public Sector

    NARCIS (Netherlands)

    S. van Thiel (Sandra); F.L. Leeuw

    2002-01-01

    textabstractAdministrative reform has led to a strong increase in the use of performance assessment instruments in the public sector. However, this has also led to several unintended consequences, such as the performance paradox, tunnel vision and ‘analysis paralysis’. These unintended consequences

  18. Facts 2009 - The Norwegian petroleum sector

    Energy Technology Data Exchange (ETDEWEB)

    2009-07-01

    The publication provides a general overview of information regarding the petroleum activities on the Norwegian continental shelf. Contents: Foreword; The petroleum sector; Norwegian resource management; Government petroleum revenues; Exploration activities; Development and operations; Norwegian gas exports; Decommissioning; Research, technology; Environmental considerations; Petroleum resources; Fields in production; Fields under development; Future developments; Fields where production has ceased; Pipelines and onshore facilities. (AG)

  19. Constraints In Implementating The Agricultural Sector Employment ...

    African Journals Online (AJOL)

    The study investigated the constraints in the effective implementation of the Agricultural sector Employment programme of the National Directorate of Employment (NDE) in Enugu State. The population for the study was the 694 participants (beneficiaries) of the programme in the state. Structured questionnaire was used to ...

  20. Regional Integration, Trade and Private Sector Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    This grant will co-finance NEPRU's research program on Regional Integration, Trade and Private Sector Development. This will enable NEPRU to add value to projects funded by clients through applied policy-oriented research, and at the same time strengthen its position as the leading economic policy research institute in ...

  1. Governance of occasional multi-sector networks

    NARCIS (Netherlands)

    Treurniet, W.; Logtenberg, R.; Groenewegen, P.

    2014-01-01

    Large-scale safety and security incidents typically require the coordinated effort of multiple organisations. A networked organisation is generally seen as the most appropriate structure for coordination within safety and security collaborations. Such networks generally are mixed-sector networks in

  2. Magnets repair for 3-4 sectors

    CERN Document Server

    Rossi, L; Modena, M

    2009-01-01

    The incident in 3-4 sector has affected some 50 main LHC magnets. Such a scenario was never considered as realistic in the past. Our reserve of magnet has been barely sufficient (some 40 dipoles and 14 SSS, in some cases the reserve magnet types are not compatible with the one damaged). Furthermore the subsequent measurements on other sectors have shown the necessity to replace other magnets. The plan and methods for assessing the damage that occurred to a cold mass and the decision on its substitution, rather than a simple revamping of the magnet itself, will be discussed. The question if the magnets in the sector are adequate for powering and beam operation will be addressed. The implementation of the changes and their traceability will be presented. Finally the spare situation, which includes the plan for repairing and testing of all damaged cold masses of sector 3-4 and the impact on it of the 3-4 incident, is discussed.

  3. Nigeria's Changing Investment Climate: The Private Sector ...

    African Journals Online (AJOL)

    Evidently, active implementation of reforms since 2001 has resulted in modest positive changes in the ICT and financial sectors where the investment climate has improved the most; however poor infrastructure remains a major impediment to reaping the rewards of the gains made in macroeconomic management.

  4. The external sector of the Serbian economy

    Directory of Open Access Journals (Sweden)

    Ristanović Vladimir

    2016-01-01

    Full Text Available The aim of this paper is to show the external sector of the Serbian economy, its features and peculiarities, as well as anomalies that afflicted it for years. In the analysis, data acquired from the Statistical Office of the Republic of Serbia will be used, as well as the official international methodology. The text will include the analysis of the structure of the external sector, market share, competitive position of Serbian economy and export products according to sectors of the economy and factor intensity. Since 2000, the structure of production and exports of the Serbian economy shows low comparative advantages and competitive position throughout the world. Unfavorable structure of the sectors, departments and the product groups affected the deepening of external imbalances and high foreign trade deficit. Exports of technology of predominantly low intensity, resources, and labor-intensive products, common for Serbian economy, represent no guarantee of economic growth in the long term. The causes of external imbalances should be sought in the absence of adequate export strategy, as well as in high speed of liberalization of foreign trade flows and exchange rate policy.

  5. A retrospective study in the private sector

    African Journals Online (AJOL)

    Suicidal ideation has been documented in ~7.1% of affected individuals.[4] This further illustrates the importance of early and aggressive treatment. There are no studies specifically describing acne in black patients in the private health sector in SA. Objective. To describe acne in black adults in Durban, KwaZulu-Natal.

  6. Ecological modernisation in the public catering sector

    DEFF Research Database (Denmark)

    Nielsen, Thorkild; Kristensen, Niels Heine; Mikkelsen, Bent Egberg

    2009-01-01

    In this paper we use the concept of ecological modernisation as frame to understand the relationship between two parallel developments in the public catering sector, namely the sustainability discourse and the rationalisation discourse. We argue that the two tendencies are increasingly merging. T...

  7. entre la universidad y el tercer sector

    Directory of Open Access Journals (Sweden)

    Alejandro Navas Villar

    2014-01-01

    Full Text Available El modelo de universidad actual tiende a independizarse del tercer sector. Mientras, ambas poseen recursos que pueden beneficiar al otro. La ficha de demandas es un documento que nace en la Universidad de Sevilla como respuesta a esta situación y facilita la petición de recursos del tercer sector. La ficha se puso en práctica en varias organizaciones del tercer sector de Sevilla, Cádiz, Barcelona y Navarra, cuyas demandas de recursos se convierten en datos que recopilamos y analizamos en el presente artículo. De forma complementaria, consideramos también propuestas de acercamiento entre universidad-calle desprendidas de los debates del congreso La Universidad Comprometida, celebrado en Sevilla. Este texto aporta información sobre la situación del tercer sector, permitiendo la optimización de la ficha de demandas y fundamentando otras propuestas de colaboración y cambio en la dinámica universitaria. La construcción de una universidad al servicio del bien común es el telón de fondo de este trabajo.

  8. Public Sector Information and Open Government Data

    Directory of Open Access Journals (Sweden)

    Mohammad Adly Talaat

    2016-04-01

    Full Text Available This paper tackles the distinguished case studies of some countries in the domains of Public Sector Information (PSI and Open Government Data (OGD, and demonstrates the current situation of Egypt related to them. The paper shows as well why the OGD is needed and its benefits on the political, economic, social, and international readiness axes

  9. Competitiveness measurement system in the advertising sector.

    Science.gov (United States)

    Poveda-Bautista, Rocío; García-Melón, Mónica; Baptista, Doris C

    2013-01-01

    In this paper a new approach to find indicators that can be used to measure companies' competitiveness and performance in an efficient and reliable way is presented. The aim is to assist managers of companies within a specific industrial sector by providing information about their relative position in the market so as to define better action plans that may improve the company's performance. The approach combines the use of the Analytic Network Process, a multicriteria decision method, with the Balanced Scorecard. It allows the definition of a number of competitiveness indicators based on the performance and setting of the advertising sector. In this way it is possible to obtain a Competitiveness Index that allows a company to know its relative position with respect to other companies in the sector, and establish a ranking of the companies ordered by their competitiveness level. A case study in the advertising industry of Venezuela is provided. Results show that improvement plans for the agencies analyzed should promote creativity, innovation and the use of new technologies, as a particular form of innovation. These factors were considered to be the most relevant indicators in the advertising sector. The participating experts agreed that the methodology is useful and an improvement over current competitiveness assessment methods.

  10. Testing Higgs sector of 2HDM

    OpenAIRE

    Krawczyk, Maria

    2005-01-01

    Properties of the Higgs sector of Two Higgs Doublet Model (2HDM) and existing constraints on its parameters are discussed. Potential of the Photon Linear Collider in testing various Higgs scenarios of 2HDM, including the MSSM, based on the realistic simulations is also presented.

  11. Competence Development in the Public Sector

    DEFF Research Database (Denmark)

    Hjort, Katrin

    2009-01-01

    The article analyses the popular concept of Competence Development as constructed of at least three different discourses (Life Long Learning, New Public Management and professionalisation) and discusses the relations between the transformations of the public sectors in Scandinavian Welfare States......, Competence Development and Professionalisation/Deprofessionalisation among the public employees....

  12. Sustainable development in Cameroon's forestry sector: Progress ...

    African Journals Online (AJOL)

    EJIRO

    forestry law (Law N0. 94/01 of 20th January 1994), which regulated the forestry sector in the country, the government, in particular, the Ministry of Forests and .... Forest management units. 7066647. 36.0. Sales by standing volume. 379745.2. 1.9. Protected areas. 3785653. 19.3. Total estimated forested land use regime.

  13. Organisational ecology in the Danish restaurant sector

    DEFF Research Database (Denmark)

    Hjalager, Anne Mette

    2000-01-01

    and methodological base of this article, is a promising research approach to tourism issues. The article, which focuses on explanations for the occurrence of life events in the restaurant sector, calls for more careful policy considerations than are often the case. In particular, human-resource- and labour...

  14. [Eco-efficiency of Jiaozuo industry sectors].

    Science.gov (United States)

    Du, Yan-chun; Jiang, Pan; Mao, Jian-su; Xu, Lin-yu

    2011-05-01

    Jiaozuo city was taken as a representative industry city and its industry energy consumption and industry emissions such as wastewater,solid waste, SO2, dust and so on were selected as corresponding environmental loads. The contribution rate to the environmental loads and eco-efficiencies of Jiaozuo industry sectors were analyzed quantitatively. The results show that, the industry sector with the highest energy eco-efficiency is Mining and Processing of Ferrous Metal Ores (FMM), 43.19 x 10(4) yuan x tce(-1), and its contribution rate is 0.003%; the one with the highest wastewater-related eco-efficiency is Manufacture of Transport Equipment (TRM), 3.58 x 10(4) yuan x t(-1), and its contribution rate is 0.0001%; the one with the highest solid waste-related eco-efficiency is Manufacture of Special Purpose Machinery( SMM), 323.22 x 10(4) yuan x t(-1), and its contribution rate is 0.005%; the one with the highest SO2 emission-related eco-efficiency is Manufacture of Special Purpose Machinery (SMM), 19.74 x 10(4) yuan x kg(-1), and its contribution rate is 0.0001%; the one with the highest dust emission-related eco-efficiency is Manufacture of Rubber (RUM), 6.75 x 10(4) yuan x kg(-1), and its contribution rate is 0.001%. It can be seen that the industry sector with high value of eco-efficiency always contributes less to its environmental load, which results that the industry sectors with high eco-efficiencies only play a weak role in leading the overall industry eco-efficiency. A succinct distance index (SDI) was proposed to estimate the differences between Jiaozuo and China average for their eco-efficiency of every industrial sector. The values of SDI range from -1 to 63.45, and the absolute value of SDI with positive value is much greater than that with negative value, which indicates that the values of eco-efficiencies for the advanced industry sectors of Jiaozuo city are much higher than those for China's industry sectors average.

  15. INTRODUCTION OF A SECTORAL APPROACH TO TRANSPORT SECTOR FOR POST-2012 CLIMATE REGIME

    Directory of Open Access Journals (Sweden)

    Atit TIPPICHAI

    2009-01-01

    Full Text Available Recently, the concept of sectoral approaches has been discussed actively under the UNFCCC framework as it could realize GHG mitigations for the Kyoto Protocol and beyond. However, most studies have never introduced this approach to the transport sector explicitly or analyzed its impacts quantitatively. In this paper, we introduce a sectoral approach which aims to set sector-specific emission reduction targets for the transport sector for the post-2012 climate regime. We suppose that developed countries will commit to the sectoral reduction target and key developing countries such as China and India will have the sectoral no-lose targets — no penalties for the failure to meet targets but the right to sell exceeding reductions — for the medium term commitment, i.e. 2013–2020. Six scenarios of total CO2 emission reduction target in the transport sector in 2020, varying from 5% to 30% reductions from the 2005 level are established. The paper preliminarily analyzes shares of emission reductions and abatement costs to meet the targets for key developed countries including the USA, EU-15, Russia, Japan and Canada. To analyze the impacts of the proposed approach, we generate sectoral marginal abatement cost (MAC curves by region through extending a top-down economic model, namely the AIM/CGE model. The total emission reduction targets are analyzed against the developed MAC curves for the transport sector in order to obtain an equal marginal abatement cost which derives optimal emission reduction for each country and minimizes total abatement cost. The results indicate that the USA will play a crucial role in GHG mitigations in the transport sector as it is most responsible for emission reductions (i.e. accounts for more than 70% while Japan will least reduce (i.e. accounts for about 3% for all scenarios. In the case of a 5% reduction, the total abatement is equal to 171.1 MtCO2 with a total cost of 1.61 billion USD; and in the case of a 30

  16. Financiación del Sector Salud

    Directory of Open Access Journals (Sweden)

    Ricardo Galán Morera

    1986-12-01

    Full Text Available

    Fuentes de Financiación

    Tomando como base la información proveniente de la Oficina de Planeación del Ministerio de Salud, se pudo establecer que el sector contó para la vigencia de 1985 con un total de 52.364 millones de pesos.

    El Gobierno Nacional aportó al sector salud el 51.8% de su presupuesto discriminado así: un 37.4% por concepto del Situado Fiscal y un 14.4% destinado a Hospitales de Referencia y a campañas especiales de controlo erradicación tales como la Campaña de Lepra, Tuberculosis, Malaria, etc.

    Por otra parte la comunidad en forma directa o indirecta contribuyó con el resto del presupuesto (48.2%. En este sentido los recursos del Nivel Seccional provenientes de licores, cervezas, apuestas permanentes, loterías y Beneficencias, Asambleas, Intendencias y Comisarías, Registro y Anotación y otros, contribuyeron con el 24.7% del total. La venta de servicios representó el 23.6% del presupuesto destinado al Sector Salud.

    Situado fiscal

    De un gran presupuesto nacional de 330.4 72 millones de pesos, la Ley destinó el 25% (82.618 millones de pesos para los Sectores de Salud y Educación y el resto 75% (274.854 millones de pesos para los demás sectores del desarrollo nacional...

  17. Abelian Hidden Sectors at a GeV

    Energy Technology Data Exchange (ETDEWEB)

    Morrissey, David E.; Poland, David; /Harvard U.; Zurek, Kathryn; /Fermilab /Michigan U.

    2009-04-16

    We discuss mechanisms for naturally generating GeV-scale hidden sectors in the context of weak-scale supersymmetry. Such low mass scales can arise when hidden sectors are more weakly coupled to supersymmetry breaking than the visible sector, as happens when supersymmetry breaking is communicated to the visible sector by gauge interactions under which the hidden sector is uncharged, or if the hidden sector is sequestered from gravity-mediated supersymmetry breaking. We study these mechanisms in detail in the context of gauge and gaugino mediation, and present specific models of Abelian GeV-scale hidden sectors. In particular, we discuss kinetic mixing of a U(1){sub x} gauge force with hypercharge, singlets or bi-fundamentals which couple to both sectors, and additional loop effects. Finally, we investigate the possible relevance of such sectors for dark matter phenomenology, as well as for low- and high-energy collider searches.

  18. Spectroscopic Properties of Novel Aromatic Metal Clusters: NaM4 (M=Al, Ga, In) and their Cations and Anions

    Energy Technology Data Exchange (ETDEWEB)

    Balasubramanian, K; Zhao, C

    2004-03-17

    The ground and several excited states of metal aromatic clusters, namely NaM4 and NaM{sub 4}{sup {+-}} (M=Al, Ga, In) clusters have been investigated by employing complete activespace self-consistent-field (CASSCF) followed by Multi-reference singles and doubles configuration interaction (MRSDCI) computations that included up to 10 million configurations and other methods. The ground states NaM{sub 4}{sup -} of aromatic anions are found to be symmetric C{sub 4v} ({sup 1}A{sub 1}) electronic states with ideal square pyramid geometries. While the ground state of NaIn4 is also predicted to be a symmetric C{sub 4v} ({sup 2}A{sub 1}) square pyramid, the ground state of the NaAl4 cluster is found to have a C{sub 2v} ({sup 2}A{sub 1}) pyramid with a rhombus base and the ground state of NaGa{sub 4} possesses a C{sub 2v} ({sup 2}A{sub 1}) pyramid with a rectangle base. In general these structures exhibit 2 competing geometries, viz., an ideal C{sub 4v} structure and a distorted rhomboidal or rectangular pyramid structure (C{sub 2v}). All of the ground states of the NaM{sub 4}{sup +} (M= Al, Ga, In) cations are computed to be C{sub 2v} ({sup 3}A{sub 2}) pyramids with rhombus bases. The equilibrium geometries, vibrational frequencies, dissociation energies, adiabatic ionization potentials, adiabatic electron affinities for the electronic states of NaM{sub 4} (M=Al, Ga, In) and their ions are computed and compared with experimental results and other theoretical calculations. On the basis of our computed excited states energy separations, we have tentatively suggested assignments to the observed X and A states in the anion photoelectron spectra of Al{sub 4}Na{sup -} reported by Li et al. The X state can be assigned to a C{sub 2v} ({sup 2}A{sub 1}) rhomboidal pyramid. The A state observed in the anion spectrum is assigned to the first excited state ({sup 2}B{sub 1}) of the neutral NaAl{sub 4} with the C{sub 4v} symmetry. The assignments of the excited states are consistent with

  19. Ciencia prohibida... ciencia buscada (A propósito de La ciencia del bien y del mal de Javier Echeverría

    Directory of Open Access Journals (Sweden)

    Gómez Pin, Víctor

    2007-06-01

    Full Text Available A labyrinth was the infinite for Leibniz (who declares on several occasions that,as much from the angle of the infinite large as from that of the infinite small, infinity is nothing but a fiction in the attempts of thought to explain the phenomena. But another labyrinth was also for him the problem of the evilness, together with the correlative problem of goodness. Used, since he was a young mathematician, to the Leibnizian puzzle of the infinite, Javier Echeverría faces now the second labyrinth. And he approaches the subject by restoring the biblical myth of the tree that hides the mystery. Taken implicitly the opposite point of view that leads Kant to assert the intrinsic division of the reason, Echeverría, from the very title of his book, aims at goodness and evilness as effective goals for science. In this paper we discuss some implications of Echeverría’s bet.

    Un laberinto era el infinito para Leibniz (quien afirma en varias ocasiones que tanto lo infinitamente grande como lo infinitamente pequeño no son sino ficciones para el pensamiento que busca la explicación de los fenómenos pero laberinto era asimismo, para él, la cuestión del mal, indisociable de problema del bien. Curtido, desde sus años de joven matemático, en el leibniziano puzzle del infinito y el continuo, Javier Echeverría se confronta ahora al segundo laberinto. Y lo hace restaurando el bíblico relato del árbol cuyo fruto escondería el misterio. Tomando implícitamente una vía opuesta a la que conduce a la kantiana división de la razón, Echeverría apunta a hacer de la polaridad bien-mal objeto de efectiva ciencia. En este escrito discutimos alguna de las implicaciones de su apuesta.

  20. Correction of vitamin D deficiency using sublingually administered vitamin D2 in a Crohn's disease patient with mal-absorption and a new ileostomy.

    Science.gov (United States)

    McCullough, Patrick; Heaney, Robert

    2017-10-01

    Vitamin D deficiency has been shown to be associated with many adverse health problems. Studies have shown that patients with Crohn's disease who have low vitamin D levels have a poorer quality of life than those with more adequate levels. It has also been shown that patients with mal-absorption problems have a difficult time achieving normal vitamin D levels in spite of aggressive supplementation, and that exposure to UVB radiation may be the most effective treatment option for these patients. We present a case in which 25-hydroxyvitamin D levels were normalized within 2 weeks in a severely vitamin D deficient patient with Crohn's disease with mal-absorption and a new ileostomy, utilizing sublingually administered vitamin D2. A 58 year-old white female was admitted with a new ileostomy following partial bowel resection due to complications from Crohn's disease. She was found to be severely vitamin D deficient at the time of admission, with a level of 6.1ng/ml on hospital day 3. Her treatment with vitamin D was delayed for a few days. She was initially treated with 5000 units of vitamin D3 orally twice a day for 3days (days 7-10). After discussion with the patient and obtaining her consent, vitamin D3 was stopped, and she was then treated with a total of 8 doses of 50,000 units of vitamin D2 administered sublingually. She was given the first 3 doses on alternating days (days 11, 13, 15), and then 5 more doses on consecutive days (days 17-21). The rise in her 25-hydroxyvitamin D level in response to treatment with sublingual vitamin D2 was significant. On day 10, after receiving 3days of orally administered vitamin D3, her level was 9.8ng/ml. One week later, after receiving 3 sublingual doses of vitamin D2, it rose to 20.3ng/ml. It was then measured on alternating days twice over the next 4days, and it rose to 45.5ng/ml, and then to 47.4ng/ml on the day of discharge to home. The major finding of this study is that sublingual administration of vitamin D2 appears to

  1. Mal de Pott en pediatría: presentación de 5 casos y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    Gladys Abreu Suárez

    2002-09-01

    Full Text Available Se presentan 5 de los 6 niños afectados de mal de Pott en el período de 1995 a 2001, para una incidencia del 4,5 % del total de casos de tuberculosis infantil en Cuba. La mayoría de los niños tenía alrededor de 2 años de edad, con un predominio de la afectación lumbar en 4 pacientes. El cuadro clínico fue insidioso, y fueron más frecuentes el dolor de espalda y los trastornos a la marcha. El diagnóstico fue clinicorradiológico, y la tuberculina positiva en 4 niños. Sólo se aisló Micobacterium tuberculosis en un paciente, en el que concomitaban lesiones pulmonares. En 3 enfermos se hallaron abscesos paravertebrales (2 en la región dorsal, y el otro en el psoas. Aún se encuentran 3 pacientes en tratamiento; de los 2 curados, uno tiene pérdida de la lordosis fisiológica lumbar, y otro perdió un cuerpo vertebral con una giba residual ligera. Se concluye que, aunque la tuberculosis infantil no es un problema de salud en Cuba, y el mal de Pott no es frecuente, debe tenerse en cuenta ante un niño pequeño que se consulte con manifestaciones insidiosas de trastornos de la marcha y dolor de espalda.5 of the 6 children affected by Pott’s disease from 1995 to 2001 are presented in this paper for an incidence of 4.5 % of the total of cases of infantile tuberculosis in Cuba. Most of the children were about 2 years old. A predominance of lumbar affection was observed in 4 patients. The clinical picture was insidious and back pain and walking disorders were more frequent. The diagnosis was clinicoradiological and tuberculin was positive in 4 children. Micobacterium tuberculosis was only isolated from a patient with concomitant pulmonary injuries. Paravertebral abscesses (2 in the dorsal region and the other in the psoas were found in 3 patients. There are still 3 patients under treatment: one of the two that were cured suffers from loss of the physiological lumbar lordosis and the other lost a vertebral body and presents a mild residual

  2. Universal Industrial Solution and Industrial Sectors Module for Pulp and Paper Sector

    Science.gov (United States)

    Increased concerns over air pollution and its detrimental effects on health have called for more stringent emission reduction strategies in the industrial sector. However, stringent regulatory policies can potentially adversely affect domestic and international trade. Therefore E...

  3. Sectoral Innovation Foresight. Wholesale and Retail Trade Sector. Final Report. Task 2

    NARCIS (Netherlands)

    Giesecke, S.; Schaper-Rinkel

    2010-01-01

    The internationalization, concentration and differentiation of retailing is challenging the traditional retail and wholesale sector organisation and its distribution structures that firms have employed to get goods and services to market. With the intensification of competition and speed of change

  4. Russian financial sector: adjustment and management

    Directory of Open Access Journals (Sweden)

    Vitaly J. Ozira

    2006-12-01

    Full Text Available This paper reviews general issues relate to Russian financial system and policies in the context of economies relying to a significan extent on market mechanisms to allocate resources. After a brief introduction describing the functions of the financial sector in a marke economy, the paper presents an inventory o the most common problems hindering the effective performance of the financial system as a development tool, and some policy guideline based on the analysis. The text aims a presenting a brief exposition of the basic principles that provide a conceptual framework to review the issues.Finance, like money, is not a realit which exists independently from the specific cultural, political and legal features of a given society. The reason is that finance is ai institution, which organizes relevant modes o interaction among various groups or individual economic units claims on the social resources, the functions fulfilled by the financial sector need not be the universal.The views expressed in the paper are the author's own responsibility and should not be interpreted as presenting the official position paper on financial sector management.El presente artículo examina problemas generales concernientes al sector financiero de Rusia a la luz del sistema económico apoyado en los mecanismos de mercado de la distribución de los recursos. Después de la introducción que describe las funciones de dicho sector en las condiciones de mercado, el artículo representa un cuadro típico de problemas que frenan el funcionamiento eficaz del sistema financiero como instrumento de desarrollo. Asimismo el autor ofrece recomendaciones prácticas basadas en el resultado del análisis llevado a cabo por él. El texto del artículo contiene los principios fundamentales que son, propiamente dicho, los marcos conceptuales del presente trabajo.Las finanzas, como es sabido, están estrechamente vinculadas a las peculiaridades jurídicas, políticas y culturales de

  5. Modelling of Systemic Risk of Banking Sector

    Directory of Open Access Journals (Sweden)

    Laura Gudelytė

    2014-03-01

    Full Text Available Purpose – to evaluate the general networking and simulation approaches of modelling of systemic risk and the financial contagion and their ability to assess the banking sector resilience in the case of external economic shocks and collapse of idiosyncratic financial institutions.Design/methodology/approach – a general overview of research papers presenting concepts and methodologies of assessment of systemic risk of the banking sector.Findings – limitations of the networking approach and possible ways to improve modelling of systemic risk. The network approach cannot explain the causes of initial default of bank. On the other hand, assumptions made on LGD and interbank exposures are very strong. These features are important limitations of network and simulation approaches.Research limitations/implications – the application of reviewed methods in the case of Lithuanian banking sector falls, however, due to the lack of exhaustive data. On the other hand, until now, applied methods for systemic risk due to the lack of data have been limited. Also, because of this reason, there are difficulties to create adequate dynamic assessment for systemic risk models. Therefore, in assessing systemic risk of the banking sector, the same problem remains: is it possible to parameterize the financial crisis, its spread and speed and other characteristics according to quantitative methods. Knowing the liquidity, credit risk and other standards set in Basel Accords, it is also not enough to properly manage the systemic risk of the whole banking sector because for the proper activity of the banking sector not only characteristics related to capital requirements have influence on it, but also external (mostly the macroeconomic, political factors.Practical implications – determination of the explicit connection based on quantitative methods determining the systemic risk of the banking sector would be exact and objective assessment and useful not only for the

  6. Juan de Mal Lara, La Philosophía vulgar, éd. de Inoria Pepe Sarno et José-María

    OpenAIRE

    Oddo, Alexandra

    2014-01-01

    Deux éditions critiques de la Filosofía vulgar de Mal Lara ont précédé cet imposant volume de 1506 pages publié chez Cátedra, celle de Vilanova (1958-1959) et celle de Bernal Rodríguez en 1996 (Obras Completas, I). Dans les trois cas, le texte est établi à partir de la première édition de l’œuvre (Séville, 1568), la seule où figurent les deux très longs préambules de l’auteur. Mal Lara y développe un véritable traité de parémiologie où seront abordées diverses questions, notamment celle de la...

  7. Nota sobre surto de malária em usuários de drogas injetáveis Note on the malaria outbreak in users of injectable drugs

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Barradas Barata

    1990-08-01

    Full Text Available Relata-se surto de malária por Plasmodium vivax entre usuários de drogas injetáveis, detectado na cidade de Bauru, Estado de São Paulo, Brasil. Até julho de 1989 12 casos haviam sido confirmados pelo exame de gota espessa, e 20 outros contactantes suspeitos estavam sendo investigados. Todos os casos relataram uso freqüente de cocaína injetável, compartilhando seringas e agulhas, e negaram viagens por áreas endêmicas de malária.An outbreak of Plasmodium vivax malaria among drug addicts in Bauru, S. Paulo State, Brazil, is reported. Until July 1989,12 cases had been confirmed by thick smear examinations and 20 contacts were being investigated. All of them reported frequent use of intravenous cocaine and sharing of needles and syringes but deny having travelled through endemic malarial areas.

  8. Multi-sectoral action for child safety-a European study exploring implicated sectors.

    Science.gov (United States)

    Scholtes, Beatrice; Schröder-Bäck, Peter; Förster, Katharina; MacKay, Morag; Vincenten, Joanne; Brand, Helmut

    2017-06-01

    Injury to children in Europe, resulting in both death and disability, constitutes a significant burden on individuals, families and society. Inequalities between high and low-income countries are growing. The World Health Organisation Health 2020 strategy calls for inter-sectoral collaboration to address injury in Europe and advocates the whole of government and whole of society approaches to wicked problems. In this study we explore which sectors (e.g. health, transport, education) are relevant for four domains of child safety (intentional injury, water, road and home safety). We used the organigraph methodology, originally developed to demonstrate how organizations work, to describe the governance of child safety interventions. Members of the European Child Safety Alliance, working in the field of child safety in 24 European countries, drew organigraphs of evidence-based interventions. They included the different actors involved and the processes between them. We analyzed the organigraphs by counting the actors presented and categorizing them into sectors using a pre-defined analysis framework. We received 44 organigraphs from participants in 24 countries. Twenty-seven sectors were identified across the four domains. Nine of the 27 identified sectors were classified as 'core sectors' (education, health, home affairs, justice, media, recreation, research, social/welfare services and consumers). This study reveals the multi-sectoral nature of child safety in practice. It provides information for stakeholders working in child safety to help them implement inter-sectoral child safety interventions taking a whole-of-government and whole-of-society approach to health governance.

  9. The Climate Change and Rwandan Coffee Sector

    Directory of Open Access Journals (Sweden)

    Fidele Hakorimana

    2017-10-01

    Full Text Available This paper provides a detailed overview of the current situation of the coffee sector in the Rwandan economy and identifies the possible challenges that the sector is currently facing. The study has identified the economic and the livelihood indicators for farmers who are engaged in coffee production and also gives the Rwandan coffee sector’ situation and its position in the global coffee market. Also, the research has found out that in Rwanda, nearly 500,000 farmers produce coffee along with other crops, notably beans, savory banana and corn and found out that in 2012, coffee accounted for almost 30 percent of Rwanda’s total export revenue. On the other hand, the study revealed that the sector throughout all the coffee production process, has undergone different challenges especially climate change as it is reported by the Ministry of Agriculture and Animal resources. A low yield was reported in 2007 and climate variability was quoted among the causes. Insufficient rainfall in the last three months of 2006 (the period of coffee flowering proceeding the short dry season in the first two months of 2007 was recorded. The reduced rainfall was also poorly distributed across coffee growing regions in Rwanda. In addition, the research revealed that even though the area under coffee production is increasing, the coffee production is decreasing due to unexpected climate change and variability in current years and also the improper use of chemical fertilizers by coffee farmers is very critical. The study concluded that adding value to the coffee supply chain of Rwanda is adding direct economic benefits and important indirect social benefits to the lives of individuals and to the health of communities in Rwanda. Moreover, more effort should continue to raise the profile of the Rwandan coffee sector suggesting that proper use of chemical fertilizers, solid marketing channels and climate change adaptations measures would be the fair ways of making the

  10. Geochemistry of amphibolites and related graphitic gneisses from the Suchý and Malá Magura Mountains (central Western Carpathians – evidence for relics of the Variscan ophiolite complex

    Directory of Open Access Journals (Sweden)

    Ivan Peter

    2015-10-01

    Full Text Available Three small bodies of amphibolites and associated graphitic gneisses from the Suchý and Malá Magura Mountains (Tatric Megaunit, central Western Carpathians have been studied by petrographic and geochemical methods. Isolated, fault-bounded bodies first hundreds of meters in size are located in the complex of the Early Paleozoic paragneisses and migmatites intruded by the Lower Carboniferous granitoid rocks. Amphibolites (locally actinolite schists were formed from effusive basalts, dolerites or isotropic gabbros hydrothermally altered and veined before the regional metamorphic transformation. Distribution of the trace elements relatively immobile during the metamorphic alteration (HFSE, REE, Cr, V, Sc is similar to E-MORB type in the Malá Magura Mountain or to N-MORB/E-MORB types in the Suchý Mountain. Graphitic gneisses to metacherts are rich in silica (up to 88 wt. % and Ctot, poor in other major element contents and display negative Ce-anomaly, enrichment in HREE, V, Cr and U. They were probably originally deposited as non-carbonate and silica-rich deep-sea sediments in anoxic conditions. The oceanic provenance of amphibolites and related graphitic gneisses clearly indicates their oceanic crust affinity and identity with the uppermost part of the ophiolite sequence. Ophiolite bodies from the Suchý and Malá Magura Mountains are supposed to be relic fault blocks identical with the Upper Devonian Pernek Group which represents a Variscan ophiolite nappe preserved to large extent in the Malé Karpaty Mountains located in the Tatric Megaunit further to the southwest. All these ophiolite relics are vestiges of the original ophiolite suture created by oceanic closure in the Lower Carboniferous.

  11. Geochemistry of amphibolites and related graphitic gneisses from the Suchý and Malá Magura Mountains (central Western Carpathians) - evidence for relics of the Variscan ophiolite complex

    Science.gov (United States)

    Ivan, Peter; Méres, Štefan

    2015-10-01

    Three small bodies of amphibolites and associated graphitic gneisses from the Suchý and Malá Magura Mountains (Tatric Megaunit, central Western Carpathians) have been studied by petrographic and geochemical methods. Isolated, fault-bounded bodies first hundreds of meters in size are located in the complex of the Early Paleozoic paragneisses and migmatites intruded by the Lower Carboniferous granitoid rocks. Amphibolites (locally actinolite schists) were formed from effusive basalts, dolerites or isotropic gabbros hydrothermally altered and veined before the regional metamorphic transformation. Distribution of the trace elements relatively immobile during the metamorphic alteration (HFSE, REE, Cr, V, Sc) is similar to E-MORB type in the Malá Magura Mountain or to N-MORB/E-MORB types in the Suchý Mountain. Graphitic gneisses to metacherts are rich in silica (up to 88 wt. %) and Ctot, poor in other major element contents and display negative Ce-anomaly, enrichment in HREE, V, Cr and U. They were probably originally deposited as non-carbonate and silica-rich deep-sea sediments in anoxic conditions. The oceanic provenance of amphibolites and related graphitic gneisses clearly indicates their oceanic crust affinity and identity with the uppermost part of the ophiolite sequence. Ophiolite bodies from the Suchý and Malá Magura Mountains are supposed to be relic fault blocks identical with the Upper Devonian Pernek Group which represents a Variscan ophiolite nappe preserved to large extent in the Malé Karpaty Mountains located in the Tatric Megaunit further to the southwest. All these ophiolite relics are vestiges of the original ophiolite suture created by oceanic closure in the Lower Carboniferous.

  12. The electric tariff in the residential sector; Tarificacion electrica en el sector residencial

    Energy Technology Data Exchange (ETDEWEB)

    Sheinbaum Pardo, Claudia [Instituto de Ingenieria, Universidad Nacional Autonoma de Mexico (UNAM), Mexico, D. F. (Mexico)

    1997-12-31

    The main objective of this paper is to make an historical revision and analyze the current condition of the electric tariffs in the Mexican residential sector and ask ourselves if the equalization of tariffs generates the possibility that the entire population has access to the electricity service. The document is divided into three parts. The first one presents the history and the tendencies of the tariffs in the domestic sector in Mexico since 1973 until 1996 and the current tariff structure. The second one describes the characteristics of the residential users and mention is made of how the increment of the electric tariffs would affect the various population sectors. The last part of this paper presents some tariff criteria, that take into account energy conservation measures [Espanol] El objetivo principal de este trabajo es hacer una revision historica y analizar la situacion actual de las tarifas electricas en el sector residencial mexicano y preguntarnos si la igualdad de tarifas genera la posibilidad de que toda la poblacion tenga acceso al servicio electrico. El documento se divide en tres partes. La primera presenta la historia y tendencias de las tarifas del sector domestico en Mexico desde 1973 hasta 1996 y la estructura tarifaria actual. La segunda describe las caracteristicas de los usuarios residenciales y se menciona como afectaria el incremento de las tarifas electricas a los distintos sectores de la poblacion. La ultima parte de este trabajo presenta algunos criterios de tarificacion, que toman en cuenta medidas de ahorro de energia

  13. Linfoma Nasal de Células T/Natural Killer Extranodal Refractario Mal Diagnosticado, Tratado de Manera Exitosa: Informe de Caso

    Directory of Open Access Journals (Sweden)

    José Domingo Saavedra Ramírez

    2017-12-01

    Full Text Available El linfoma de células T/natural killer extranodal (“extranodal natural killer/T-cell lymphoma”, ENKL nasal es un linfoma no Hodgkin (LNH agresivo y poco común para el cual no se ha establecido un tratamiento de referencia claro, especialmente en el escenario de la enfermedad recidivante/refractaria. Debido a su rareza, no se han llevado a cabo ensayos aleatorizados específicamente en ENKL nasal; sin embargo, los informes de caso y las series de caso pequeñas ofrecen un conocimiento importante sobre nuevos tratamientos potenciales. Presentamos el informe de caso de un paciente con ENKL nasal (previamente mal diagnosticado como una sinusitis crónica recidivante en quien la enfermedad progresó durante la quimioterapia con múltiples agentes pero respondió al tratamiento de segunda línea con pralatrexato como agente único. Analizamos opciones de tratamiento para el ENKL nasal recidivante/refractario y sugerimos que el pralatrexato se evalúe más a fondo en este escenario clínico.

  14. The crystal and magnetic structures of LaCa2Fe3-xMxO8 (M=Al, Ga, In)

    Science.gov (United States)

    Goossens, D. J.; Henderson, L. S. F.; Trevena, S.; Hudspeth, J. M.; Avdeev, M.; Hester, J. R.

    2012-12-01

    LaCa2Fe3O8 (A3B3O8) is an example of a layered structure in that it consists of pairs of octahedral, perovskite-like layers alternating with a single tetrahedral layer. This work explores the doping of non-magnetic group 13 elements, M=Al, Ga and In, onto the B-site of LaCa2Fe3-xMxO8 as a function of x. The structural and magnetic effects are examined using a combination of neutron and X-ray diffraction. Solubility limits are established. It is found that for M=Ga the solubility limit occurs between x=1.0 and x=1.25, for the synthesis conditions used, while there is evidence for low (xLaCa2Fe2GaO8 has been examined using neutron diffraction at 3.2 K and room temperature. At low temperature the staggered moment per Fe3+ is 3.8(1)μB in LaCa2Fe3O8 and 4.8(1)μB in LaCa2Fe2GaO8. The magnetic space group (P2b21‧ma‧) and moment direction (along c) does not appear to change with Ga substitution.

  15. Metodologie pro podporu procesního řízení a jejich aplikace v prostředí malých firem

    OpenAIRE

    Farkaš, Jaroslav

    2007-01-01

    V této práci se zabývám problematikou procesního řízení s ohledem na možnosti implementace v prostředí malých firem. Práce obsahuje teoretickou část, která poskytuje přehled procesních metodik a část praktickou, ve které nejprve vybírám podstatné vlastnosti procesně orientovaných metodik a na základě těchto klíčových komponent vytvářím vlastní metodiku, kterou následně aplikuji na procesy firmy Memos Software. Součástí práce je také detailní plán zavádění metodiky a rozsáhlá příloha obsahujíc...

  16. INTERVENCIÓN FAMILIAR PARA EL MANEJO PSICOLÓGICO EN PACIENTES ONCOLÓGICOS CON MAL PRONÓSTICO EN EL HOSPITAL DE LA MISERICORDIA

    Directory of Open Access Journals (Sweden)

    Martha Restrepo Forero

    2004-06-01

    Full Text Available Se diseñó un programa fundamentado en el modelo cognitivo conductual de Inoculación de Estrés e intervención en duelo anticipatorio basado en cuatro tareas. El programa fue aplicado a tres pacientes con mal pronóstico del Servicio de Oncohematología del Hospital de la Misericordia y a sus familias. Por medio de estudio de caso, se describieron factores de riesgo y de protección así como respuestas frente a dicha intervención. El análisis cualitativo de casos arrojó la descripción de respuestas a pérdidas previas no elaboradas, pautas de comunicación deficiente en uno de los casos, y reconocimiento de apoyo al interior de cada familia. Según el reporte de los participantes, la intervención permitió la expresión de sentimientos, la reflexión sobre el sentido de la vida, incremento de posibilidades y habilidades de comunicación y orientación hacia la solución de problemas y toma de decisiones.

  17. In vivo subcellular localization of Mal de Rio Cuarto virus (MRCV) non-structural proteins in insect cells reveals their putative functions

    Energy Technology Data Exchange (ETDEWEB)

    Maroniche, Guillermo A.; Mongelli, Vanesa C.; Llauger, Gabriela; Alfonso, Victoria; Taboga, Oscar [Instituto de Biotecnologia, CICVyA, Instituto Nacional de Tecnologia Agropecuaria (IB-INTA), Las cabanas y Los Reseros s/n. Hurlingham Cp 1686, Buenos Aires (Argentina); Vas, Mariana del, E-mail: mdelvas@cnia.inta.gov.ar [Instituto de Biotecnologia, CICVyA, Instituto Nacional de Tecnologia Agropecuaria (IB-INTA), Las cabanas y Los Reseros s/n. Hurlingham Cp 1686, Buenos Aires (Argentina)

    2012-09-01

    The in vivo subcellular localization of Mal de Rio Cuarto virus (MRCV, Fijivirus, Reoviridae) non-structural proteins fused to GFP was analyzed by confocal microscopy. P5-1 showed a cytoplasmic vesicular-like distribution that was lost upon deleting its PDZ binding TKF motif, suggesting that P5-1 interacts with cellular PDZ proteins. P5-2 located at the nucleus and its nuclear import was affected by the deletion of its basic C-termini. P7-1 and P7-2 also entered the nucleus and therefore, along with P5-2, could function as regulators of host gene expression. P6 located in the cytoplasm and in perinuclear cloud-like inclusions, was driven to P9-1 viroplasm-like structures and co-localized with P7-2, P10 and {alpha}-tubulin, suggesting its involvement in viroplasm formation and viral intracellular movement. Finally, P9-2 was N-glycosylated and located at the plasma membrane in association with filopodia-like protrusions containing actin, suggesting a possible role in virus cell-to-cell movement and spread.

  18. Avaliação da investigação de óbitos por causas mal definidas no Brasil em 2010

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    Carolina Cândida da Cunha

    Full Text Available Resumo Objetivo: avaliar os resultados da investigação de óbitos por causas mal definidas (CMD para a melhoria dos dados sobre mortalidade por causas no Brasil. Métodos: estudo descritivo com dados do Sistema de Informações sobre Mortalidade (SIM, sendo selecionados todos os óbitos por CMD ocorridos em 2010; os óbitos foram estudados segundo grandes regiões nacionais, estados, capitais e características das investigações realizadas. Resultados: o percentual de óbitos por CMD no país em 2010 reduziu-se de 8,6% para 7,0% após investigação, e de 4,7% para 3,4% nas capitais após investigação; aproximadamente 65% dos óbitos por CMD tiveram a causa básica reclassificada para uma causa definida, tanto nos estados como nas capitais. Conclusão: houve melhoria nos dados sobre causas de morte, resultante das investigações que levaram a decréscimo importante no percentual de CMD nos estados e capitais do país, embora permaneçam diferenças regionais.

  19. la originalidad del regionalismo castellano y leonés en 1931 y 1932. ¿Un proyecto genuino o la necesidad de asumir un mal menor?

    Directory of Open Access Journals (Sweden)

    Luis Felipe PALACIOS

    2016-05-01

    Full Text Available Entre 1931 y 1932, como ocurrió en otras regiones españolas, Castilla y León asistió al resurgir de un regionalismo que hasta la fecha apenas había dado síntomas de vitalidad. A partir de esta realidad la pregunta que surge es si la renovada actividad regionalista castellano y leonesa reflejaba la actualización de un sentir originario y bien arraigado o era una respuesta obligada por el avance que estaba logrando el catalanismo durante el período considerado y por el nuevo modelo de organización territorial del Estado que definió la nueva Constitución de 1931. A la vista del comportamiento y manifestaciones de las fuerzas políticas, sociales e institucionales castellano y leonesas, podemos concluir que el regionalismo castellano y leonés no respondió a un sentimiento genuino y propio sino que fue la consecuencia de la necesidad de asumir un mal menor, de la adaptación a un nuevo modelo territorial no deseado.

  20. Linfoma Nasal de Células T/Natural Killer Extranodal Refractario Mal Diagnosticado, Tratado de Manera Exitosa: Informe de Caso

    Science.gov (United States)

    Saavedra Ramírez, José Domingo

    2017-01-01

    El linfoma de células T/natural killer extranodal (“extranodal natural killer/T-cell lymphoma”, ENKL) nasal es un linfoma no Hodgkin (LNH) agresivo y poco común para el cual no se ha establecido un tratamiento de referencia claro, especialmente en el escenario de la enfermedad recidivante/refractaria. Debido a su rareza, no se han llevado a cabo ensayos aleatorizados específicamente en ENKL nasal; sin embargo, los informes de caso y las series de caso pequeñas ofrecen un conocimiento importante sobre nuevos tratamientos potenciales. Presentamos el informe de caso de un paciente con ENKL nasal (previamente mal diagnosticado como una sinusitis crónica recidivante) en quien la enfermedad progresó durante la quimioterapia con múltiples agentes pero respondió al tratamiento de segunda línea con pralatrexato como agente único. Analizamos opciones de tratamiento para el ENKL nasal recidivante/refractario y sugerimos que el pralatrexato se evalúe más a fondo en este escenario clínico. PMID:29430232