WorldWideScience

Sample records for science reserve cdr

  1. Communicating marine reserve science to diverse audiences

    Science.gov (United States)

    Grorud-Colvert, Kirsten; Lester, Sarah E.; Airamé, Satie; Neeley, Elizabeth; Gaines, Steven D.

    2010-01-01

    As human impacts cause ecosystem-wide changes in the oceans, the need to protect and restore marine resources has led to increasing calls for and establishment of marine reserves. Scientific information about marine reserves has multiplied over the last decade, providing useful knowledge about this tool for resource users, managers, policy makers, and the general public. This information must be conveyed to nonscientists in a nontechnical, credible, and neutral format, but most scientists are not trained to communicate in this style or to develop effective strategies for sharing their scientific knowledge. Here, we present a case study from California, in which communicating scientific information during the process to establish marine reserves in the Channel Islands and along the California mainland coast expanded into an international communication effort. We discuss how to develop a strategy for communicating marine reserve science to diverse audiences and highlight the influence that effective science communication can have in discussions about marine management. PMID:20427745

  2. Advance Network Reservation and Provisioning for Science

    Energy Technology Data Exchange (ETDEWEB)

    Balman, Mehmet; Chaniotakis, Evangelos; Shoshani, Arie; Sim, Alex

    2009-07-10

    We are witnessing a new era that offers new opportunities to conduct scientific research with the help of recent advancements in computational and storage technologies. Computational intensive science spans multiple scientific domains, such as particle physics, climate modeling, and bio-informatics simulations. These large-scale applications necessitate collaborators to access very large data sets resulting from simulations performed in geographically distributed institutions. Furthermore, often scientific experimental facilities generate massive data sets that need to be transferred to validate the simulation data in remote collaborating sites. A major component needed to support these needs is the communication infrastructure which enables high performance visualization, large volume data analysis, and also provides access to computational resources. In order to provide high-speed on-demand data access between collaborating institutions, national governments support next generation research networks such as Internet 2 and ESnet (Energy Sciences Network). Delivering network-as-a-service that provides predictable performance, efficient resource utilization and better coordination between compute and storage resources is highly desirable. In this paper, we study network provisioning and advanced bandwidth reservation in ESnet for on-demand high performance data transfers. We present a novel approach for path finding in time-dependent transport networks with bandwidth guarantees. We plan to improve the current ESnet advance network reservation system, OSCARS [3], by presenting to the clients, the possible reservation options and alternatives for earliest completion time and shortest transfer duration. The Energy Sciences Network (ESnet) provides high bandwidth connections between research laboratories and academic institutions for data sharing and video/voice communication. The ESnet On-Demand Secure Circuits and Advance Reservation System (OSCARS) establishes

  3. Veterinary Science Students, Center Changing a Reservation

    Science.gov (United States)

    Blackwater, Jasmine

    2011-01-01

    Kayenta is a rural community located in northeastern Arizona on a Navajo reservation. On the reservation, many families rely on their livestock for income, and as a result, many reservation high school students show a great interest in agricultural education. Having livestock on the reservation is not just a source of income, but also part of a…

  4. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    Department of Medical Laboratory Science, School of Basic Medical. Sciences .... an impaired immune system leading to ... function in HIV infected people may be due ... disorders in chronic kidney disease. ... Immunology 2003;110:131-. 140.

  5. JMBR vol 7.cdr

    African Journals Online (AJOL)

    Tope

    1. Department of Physiology, College of Medical Sciences,. University of Benin, P.M.B. 1156, Benin ... were on insulin, metformin or glibenclamide treatment and 25 non-diabetic subjects matched by ..... in type 1 Insulin dependent diabetes.

  6. Oyesiku (1).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Department of Plant Science and Applied Zoology, Olabisi Onabanjo University, Ago-Iwoye, Ogun State, Nigeria. ... dehydration from which they rapidly recover on rehydration. The main ... under tap water on a metal screen (mesh 20) to.

  7. Valid Journal.cdr

    African Journals Online (AJOL)

    on to declare that mental science is revealing more clearly the nature of those ... with the socio-cultural changes of the society, and this evolution has come to be known as dance ... dispositions include exorcising illness and other form of misfortune ..... in Africa should do what their Asian counterpart did with their marshal art.

  8. Imande (7).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    In many of the variables used in the physical, biological, social and medical science, measurement errors are found. These errors, which could be problematic in .... (v) Use the values σ and σ to adjust for hm. hX measurement error in the variable (s) of interest and hence re-estimate the k-level model accordingly via Gibbs ...

  9. Adewuyi et al (19).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Ife Journal of Science vol. 17, no. ... Department of Chemistry, College of Physical Sciences, Federal University of Agriculture, Abeokuta, Ogun State,. Nigeria. ... coatings, paint and other industrial coatings as binder in ..... library generation.

  10. RJHS 5(4).cdr

    African Journals Online (AJOL)

    USER

    Department of Basic Medical Sciences, Achievers University, Owo, Nigeria. 4. Department ... Research Journal of Health Sciences subscribed to terms and conditions of Open Access publication. Articles are ..... Bearing in mind that these two ...

  11. CDR3 analysis of TCR Vβ repertoire of CD8⁺ T cells from chickens infected with Eimeria maxima.

    Science.gov (United States)

    Ren, Chao; Yin, Guangwen; Qin, Mei; Suo, Jingxia; Lv, Qiyao; Xie, Li; Wang, Yunzhou; Huang, Xiaoxi; Chen, Yuchen; Liu, Xianyong; Suo, Xun

    2014-08-01

    CD8(+) T cells play a major role in the immune protection of host against the reinfection of Eimeria maxima, the most immunogenic species of eimerian parasites in chickens. To explore the dominant complementarity-determining regions 3 (CDR3) of CD8(+) T cell populations induced by the infection of this parasite, sequence analysis was performed in this study for CDR3 of CD8(+) T cells from E. maxima infected chickens. After 5 days post the third or forth infection, intraepithelial lymphocytes were isolated from the jejunum of bird. CD3(+)CD8(+) T cells were sorted and subjected to total RNA isolation and cDNA preparation. PCR amplification and cloning of the loci between Vβ1 and Cβ was conducted for the subsequent sequencing of CDR3 of T cell receptor (TCR). After the forth infection, 2 birds exhibited two same frequent TCR CDR3 sequences, i.e., AKQDWGTGGYSNMI and AGRVLNIQY; while the third bird showed two different frequent TCR CDR3 sequences, AKQGARGHTPLN and AKQDIEVRGPNTPLN. No frequent CDR3 sequence was detected from uninfected birds, though AGRVLNIQY was also found in two uninfected birds. Our result preliminarily demonstrates that frequent CDR3 sequences may exist in E. maxima immunized chickens, encouraging the mining of the immunodominant CD8(+) T cells against E. maxima infection. Copyright © 2014 Elsevier Inc. All rights reserved.

  12. RJHS 6(1).cdr

    African Journals Online (AJOL)

    USER

    Challenges of teaching Basic Medical Sciences in Nigeria ... In Nigeria, didactic lectures which are the predominant supervised learning environment ... changed and student population increasing without comparative expansion of resources, ...

  13. Experiment Simulation Configurations Used in DUNE CDR

    Energy Technology Data Exchange (ETDEWEB)

    Alion, T. [Univ. of South Carolina, Columbia, SC (United States); Black, J. J. [Univ. of Warwick, Coventry (United Kingdom); Bashyal, A. [Oregon State Univ., Corvallis, OR (United States); Bass, M. [Univ. of Oxford (United Kingdom); Bishai, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Cherdack, D. [Colorado State Univ., Fort Collins, CO (United States); Diwan, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Djurcic, Z. [Argonne National Lab. (ANL), Argonne, IL (United States); Evans, J. [Univ. of Manchester (United Kingdom); Fernandez-Martinez, E. [Madrid Autonama Univ. (Spain); Fields, L. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Fleming, B. [Yale Univ., New Haven, CT (United States); Gran, R. [Univ. of Minnesota, Duluth, MN (United States); Guenette, R. [Univ. of Oxford (United Kingdom); Hewes, J. [Univ. of Manchester (United Kingdom); Hogan, M. [Colorado State Univ., Fort Collins, CO (United States); Hylen, J. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Junk, T. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Kohn, S. [Univ. of California, Berkeley, CA (United States); LeBrun, P. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Lundberg, B. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Marchionni, A. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Morris, C. [Univ. of California, Berkeley, CA (United States); Papadimitriou, V. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Rameika, R. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Rucinski, R. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Soldner-Rembold, S. [Univ. of Manchester (United Kingdom); Sorel, M. [Spanish National Research Council (CSIC), Valencia (Spain). Univ. of Valencia (UV), Inst. de Fisica Corpuscular; Urheim, J. [Indiana Univ., Bloomington, IN (United States); Viren, B. [Brookhaven National Lab. (BNL), Upton, NY (United States); Whitehead, L. [Univ. of Houston, TX (United States); Wilson, R. [Colorado State Univ., Fort Collins, CO (United States); Worcester, E. [Brookhaven National Lab. (BNL), Upton, NY (United States); Zeller, G. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2016-06-30

    The LBNF/DUNE CDR describes the proposed physics program and experimental design at the conceptual design phase. Volume 2, entitled The Physics Program for DUNE at LBNF, outlines the scientific objectives and describes the physics studies that the DUNE collaboration will perform to address these objectives. The long-baseline physics sensitivity calculations presented in the DUNE CDR rely upon simulation of the neutrino beam line, simulation of neutrino interactions in the far detector, and a parameterized analysis of detector performance and systematic uncertainty. The purpose of this posting is to provide the results of these simulations to the community to facilitate phenomenological studies of long-baseline oscillation at LBNF/DUNE. Additionally, this posting includes GDML of the DUNE single-phase far detector for use in simulations. DUNE welcomes those interested in performing this work as members of the collaboration, but also recognizes the benefit of making these configurations readily available to the wider community.

  14. XML Schema Guide for Primary CDR Submissions

    Science.gov (United States)

    This document presents the extensible markup language (XML) schema guide for the Office of Pollution Prevention and Toxics’ (OPPT) e-CDRweb tool. E-CDRweb is the electronic, web-based tool provided by Environmental Protection Agency (EPA) for the submission of Chemical Data Reporting (CDR) information. This document provides the user with tips and guidance on correctly using the version 1.7 XML schema. Please note that the order of the elements must match the schema.

  15. Ajikah et al (11).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Faculty of Science, Senate Building and New Hall respectively. A total of 3,495 palynomorphs belonging to about 22 families were recovered in all. The Poaceae family dominates representing 13.67 % of the total palynomorph count, followed by Cyperaceae (12.72 %) Euphorbiaceae (5.34 %) Mimosaceae (8.89 %), Fern.

  16. Cover Final May.cdr

    Indian Academy of Sciences (India)

    user

    Kane was responsible for this development and RN had a keen interest in it. The three years ... the role of language in problem solving and how children learn language. Some of his insights ... linguistics and cognitive sciences. He was one of ...

  17. The CLIC ILD CDR Geometry for the CDR Monte Carlo Mass Production

    CERN Document Server

    Muennich, A

    2012-01-01

    The CLIC ILD CDR detector for the Monte Carlo event simulation is described in a GEANT4 application, with some parameters available in a database and XML files. This makes it difficult to quickly “look up” interesting parameters of the detector geometry used for the simulation. This note summarises the important geometrical parameters and some details of the implemented detector components.

  18. XML Schema Guide for Secondary CDR Submissions

    Science.gov (United States)

    This document presents the extensible markup language (XML) schema guide for the Office of Pollution Prevention and Toxics’ (OPPT) e-CDRweb tool. E-CDRweb is the electronic, web-based tool provided by Environmental Protection Agency (EPA) for the submission of Chemical Data Reporting (CDR) information. This document provides the user with tips and guidance on correctly using the version 1.1 XML schema for the Joint Submission Form. Please note that the order of the elements must match the schema.

  19. Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.

    Science.gov (United States)

    Apgar, James R; Mader, Michelle; Agostinelli, Rita; Benard, Susan; Bialek, Peter; Johnson, Mark; Gao, Yijie; Krebs, Mark; Owens, Jane; Parris, Kevin; St Andre, Michael; Svenson, Kris; Morris, Carl; Tchistiakova, Lioudmila

    2016-10-01

    Antibodies are an important class of biotherapeutics that offer specificity to their antigen, long half-life, effector function interaction and good manufacturability. The immunogenicity of non-human-derived antibodies, which can be a major limitation to development, has been partially overcome by humanization through complementarity-determining region (CDR) grafting onto human acceptor frameworks. The retention of foreign content in the CDR regions, however, is still a potential immunogenic liability. Here, we describe the humanization of an anti-myostatin antibody utilizing a 2-step process of traditional CDR-grafting onto a human acceptor framework, followed by a structure-guided approach to further reduce the murine content of CDR-grafted antibodies. To accomplish this, we solved the co-crystal structures of myostatin with the chimeric (Protein Databank (PDB) id 5F3B) and CDR-grafted anti-myostatin antibody (PDB id 5F3H), allowing us to computationally predict the structurally important CDR residues as well as those making significant contacts with the antigen. Structure-based rational design enabled further germlining of the CDR-grafted antibody, reducing the murine content of the antibody without affecting antigen binding. The overall "humanness" was increased for both the light and heavy chain variable regions.

  20. 76 FR 52377 - Colorado Wyoming Reserve Co., Grant Life Sciences, Inc., NOXSO Corp., Omni Medical Holdings, Inc...

    Science.gov (United States)

    2011-08-22

    ... SECURITIES AND EXCHANGE COMMISSION [File No. 500-1] Colorado Wyoming Reserve Co., Grant Life Sciences, Inc., NOXSO Corp., Omni Medical Holdings, Inc., and TSI, Inc., Order of Suspension of Trading... Commission that there is a lack of current and accurate information concerning the securities of Grant Life...

  1. Optical System Critical Design Review (CDR) Flight Software Summary

    Science.gov (United States)

    Khorrami, Mori

    2006-01-01

    The Mid Infrared Instrument (MIRI FSW presentation covers: (1) Optical System FSW only and Cooling System FSW is covered at its CDR (2) Requirements & Interfaces (3) Relationship with the ISIM FSW (4) FSW Design Drivers & Solutions.

  2. Spent nuclear fuel Canister Storage Building CDR Review Committee report

    International Nuclear Information System (INIS)

    Dana, W.P.

    1995-12-01

    The Canister Storage Building (CSB) is a subproject under the Spent Nuclear Fuels Major System Acquisition. This subproject is necessary to design and construct a facility capable of providing dry storage of repackaged spent fuels received from K Basins. The CSB project completed a Conceptual Design Report (CDR) implementing current project requirements. A Design Review Committee was established to review the CDR. This document is the final report summarizing that review

  3. Barriers and opportunities for integrating social science into natural resource management: lessons from National Estuarine Research Reserves.

    Science.gov (United States)

    Robinson, Patrick; Genskow, Ken; Shaw, Bret; Shepard, Robin

    2012-12-01

    The need for cross-disciplinary scientific inquiries that facilitate improved natural resource management outcomes through increased understanding of both the biophysical and human dimensions of management issues has been widely recognized. Despite this broad recognition, a number of obstacles and barriers still sometimes challenge the successful implementation of cross-disciplinary approaches. Improving understanding of these challenges and barriers will help address them and thereby foster appropriate and effective utilization of cross-disciplinary approaches to solve natural resource management challenges. This research uses a case study analysis of the United States National Estuarine Research Reserve System to improve understanding of the critical factors that influence practitioners' decisions related to incorporating social science into their natural resource management work. The case study research is analyzed and evaluated within a Theory of Planned Behavior framework to (1) determine and describe the factors that predict practitioners' intent to incorporate social science into their natural resource related activities and (2) recommend potential strategies for encouraging and enabling cross-disciplinary approaches to natural resource management. The results indicate that National Estuarine Research Reserve practitioners' decisions related to incorporating social science are primarily influenced by (1) confidence in their own capability to incorporate social science into their work and (2) beliefs about whether the outcomes of incorporating social science into their work would be valuable or beneficial.

  4. NOAA Climate Data Record (CDR) of AVHRR Polar Pathfinder (APP) Cryosphere

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) contains the AVHRR Polar Pathfinder (APP) product. APP is a fundamental CDR comprised of calibrated and navigated AVHRR channel...

  5. NJB VOL.34 Original Lower.cdr

    African Journals Online (AJOL)

    Chukwu, M. N. and Afolabi, E. S.. Nig. ... of Pure and Applied Sciences, Faculty of Science, National Open University of Nigeria Headquarters, ... structure under different pond management to ..... of some water quality management principles in.

  6. NJB VOL.34 Original Lower.cdr

    African Journals Online (AJOL)

    2Department of Microbiology Technology, School of Science Laboratory Technology, University of Port Harcourt. ... entering the market are safe. ... the right quantity (Onurdağ et al., 2010; .... about their overall safety and consumers should.

  7. DECEMBER JMBR 13 - 2 correction.cdr

    African Journals Online (AJOL)

    Fine Print

    The effects of marijuana and cigarette use on serum levels of testosterone, the principal androgen in man has been a ... Department of Medical Laboratory Science, Ambrose Ali University,. PMB 14 ..... in cancer associated anorexia. J Palliat ...

  8. DECEMBER JMBR 13 - 2 correction.cdr

    African Journals Online (AJOL)

    Fine Print

    Department of Medical Laboratory Science,. School of Basic ... number of carbon C (2862) and hydrogen H atoms (4551) are slightly higher than other strains, thus ... The 3-D model generated a. QMEAN Z-score of ... involved in adhesion.

  9. RJHS Vol 4(2).cdr

    African Journals Online (AJOL)

    ABEOLUGBENGAS

    Spectrum of congenital heart diseases in children with Down Syndrome ... 1Paediatric Cardiology Unit, Department of Paediatrics, Usmanu Danfodiyo ... of Health Sciences subscribed to terms and conditions of Open Access publication.

  10. CLICdet: The post-CDR CLIC detector model

    CERN Document Server

    Alipour Tehrani, Niloufar; Cure, Benoit; Dannheim, Dominik; Duarte Ramos, Fernando; Elsener, Konrad; Gaddi, Andrea; Gerwig, Hubert; Green, Steven; Grefe, Christian; Hynds, Daniel; Klempt, Wolfgang; Linssen, Lucie; Nikiforou, Nikiforos; Nurnberg, Andreas Matthias; Marshall, John Stuart; Petric, Marko; Redford, Sophie; Roloff, Philipp Gerhard; Sailer, Andre; Sefkow, Felix; Sicking, Eva; Siegrist, Nicolas; Simon, Frank Richard; Simoniello, Rosa; Spannagel, Simon; Sroka, Szymon Krzysztof; Strom, Lars Rickard; Weber, Matthias Artur

    2017-01-01

    A new model for the CLIC detector has been defined based on lessons learnt while working with the CDR detector models and after a series of simulation studies. The new model, dubbed "CLICdet", also incorporates the experience from various R&D activities linked to a future experiment at CLIC. This note describes the studies and thoughts leading to the new detector model, and gives details on all of its sub-detector systems.

  11. 3(2) Supplement.cdr

    African Journals Online (AJOL)

    ABEOLUGBENGAS

    Web is defined by the Dictionary of Science as: “a hypermedia system…that allows users to view and ... plus the addition of library holdings (number of volumes). ... This ranking system utilizes a .... impact, a virtual referendum among third-.

  12. Personal Subscription 2018 revised.cdr

    Indian Academy of Sciences (India)

    user

    Resonance - Journal of Science Education. 0250-6335. 0250-5991. 0253-4142. 0022-1333. 0250-4707. 0253-4126. 0256-2499. 0253- ... Rates are inclusive of postage (ordinary post) and handling charges but with additional charges, journals can also be mailed by Registered post. 4. All correspondence regarding journal ...

  13. JMBR VOLUME 14 Number 2.cdr

    African Journals Online (AJOL)

    FINEPRINT

    JMBR: A Peer-review Journal of Biomedical Sciences pp 63-72. December 2015, Vol. 14 No. 2. ABSTRACT. Combination therapy or polytherapy is the use of more than one antibacterial agent in the treatment of a single infection. In this study, rifampicin that was mainly used in the treatment of mycobacterial infections has ...

  14. RJHS Vol 4(4).cdr

    African Journals Online (AJOL)

    ABEOLUGBENGAS

    of life, workplace efficiency and overall productivity. ... symptoms and presence of associated factors such as family history, non-steroidal ... personnel administratif du Collège des sciences de la santé de l'Université ... questionnaire included age, sex, marital status, ... The data obtained were analysed using .... An evidence-.

  15. Quantitative Proteomics Reveals the Regulatory Networks of Circular RNA CDR1as in Hepatocellular Carcinoma Cells.

    Science.gov (United States)

    Yang, Xue; Xiong, Qian; Wu, Ying; Li, Siting; Ge, Feng

    2017-10-06

    Circular RNAs (circRNAs), a class of widespread endogenous RNAs, play crucial roles in diverse biological processes and are potential biomarkers in diverse human diseases and cancers. Cerebellar-degeneration-related protein 1 antisense RNA (CDR1as), an oncogenic circRNA, is involved in human tumorigenesis and is dysregulated in hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying CDR1as functions in HCC remain unclear. Here we explored the functions of CDR1as and searched for CDR1as-regulated proteins in HCC cells. A quantitative proteomics strategy was employed to globally identify CDR1as-regulated proteins in HCC cells. In total, we identified 330 differentially expressed proteins (DEPs) upon enhanced CDR1as expression in HepG2 cells, indicating that they could be proteins regulated by CDR1as. Bioinformatic analysis revealed that many DEPs were involved in cell proliferation and the cell cycle. Further functional studies of epidermal growth factor receptor (EGFR) found that CDR1as exerts its effects on cell proliferation at least in part through the regulation of EGFR expression. We further confirmed that CDR1as could inhibit the expression of microRNA-7 (miR-7). EGFR is a validated target of miR-7; therefore, CDR1as may exert its function by regulating EGFR expression via targeting miR-7 in HCC cells. Taken together, we revealed novel functions and underlying mechanisms of CDR1as in HCC cells. This study serves as the first proteome-wide analysis of a circRNA-regulated protein in cells and provides a reliable and highly efficient method for globally identifying circRNA-regulated proteins.

  16. 6 Ghana's Quest for Oil and Gas.cdr

    African Journals Online (AJOL)

    Administrator

    reserves, countries along the Gulf of Guinea, including Ghana ... 3Science and Technology Policy Research Institute, Council for Scientific and Industrial. Research, P. O. ... However, oil exploration and production involve several activities that can have detrimental ..... auditing and inspection from government, while allowing ...

  17. NOAA Climate Data Record (CDR) of Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks (PERSIANN-CDR), Version 1 Revision 1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — PERSIANN Precipitation Climate Data Record (PERSIANN-CDR) is a daily quasi-global precipitation product for the period of 1982 to 2011. The data covers from 60...

  18. The roles of CDR1, CDR2, and MDR1 in kaempferol-induced suppression with fluconazole-resistant Candida albicans.

    Science.gov (United States)

    Shao, Jing; Zhang, MengXiang; Wang, TianMing; Li, Yue; Wang, ChangZhong

    2016-01-01

    Fungal infections caused by fluconazole-resistant Candida albicans are an intractable clinical problem, calling for new efficient antifungal drugs. Kaempferol, an active flavonoid, has been considered a potential candidate against Candida species. This work investigates the resistance reversion of kaempferol in fluconazole-resistant C. albicans and the underlying mechanism. The antifungal activities of fluconazole and/or kaempferol were assessed by a series of standard procedures including broth microdilution method, checkerboard assay and time-kill (T-K) test in nine clinical strains as well as a standard reference isolate of C. albicans. Subsequently, the morphological changes, the efflux of rhodamine 6G, and the expressions of CDR 1, CDR 2, and MDR 1 were analysed by scanning electron microscope (SEM), inverted fluorescence microscope and quantitative reverse transcription polymerase chain reaction (qRT-PCR) in C. albicans z2003. For all the tested C. albicans strains, the minimum inhibitory concentrations (MICs) of fluconazole and kaempferol ranged 0.25-32 and 128-256 μg/mL with a range of fractional inhibitory concentration index of 0.257-0.531. In C. albicans z2003, the expression of both CDR 1 and CDR 2 were decreased after exposure to kaempferol alone with negligible rhodamine 6G accumulation, while the expression of CDR 1, CDR 2 and MDR 1 were all decreased when fluconazole and kaempferol were used concomitantly with notable fluorescence of rhodamine 6G observed. Kaempferol-induced reversion in fluconazole-resistant C. albicans might be likely due to the suppression of the expression of CDR1, CDR2 and MDR1.

  19. Creating a Minor in Applied Data Science: Case Western Reserve University Engages Business Leaders to Produce T-Shaped Professionals. A BHEF Case Study

    Science.gov (United States)

    Business-Higher Education Forum, 2016

    2016-01-01

    This case study examines how Business-Higher Education Forum (BHEF) member Case Western Reserve University is integrating T-shaped skills into a minor in applied data science. Through the collaboration of its business and higher education members, BHEF launched the National Higher Education and Workforce Initiative to create new undergraduate…

  20. ABC transporter Cdr1p harbors charged residues in the intracellular loop and nucleotide-binding domain critical for protein trafficking and drug resistance.

    Science.gov (United States)

    Shah, Abdul Haseeb; Banerjee, Atanu; Rawal, Manpreet Kaur; Saxena, Ajay Kumar; Mondal, Alok Kumar; Prasad, Rajendra

    2015-08-01

    The ABC transporter Cdr1 protein of Candida albicans, which plays a major role in antifungal resistance, has two transmembrane domains (TMDs) and two nucleotide-binding domains (NBDs). The 12 transmembrane helices of TMDs that are interconnected by extracellular and intracellular loops (ICLs) mainly harbor substrate recognition sites where drugs bind while cytoplasmic NBDs hydrolyze ATP which powers drug efflux. The coupling of ATP hydrolysis to drug transport requires proper communication between NBDs and TMDs typically accomplished by ICLs. This study examines the role of cytoplasmic ICLs of Cdr1p by rationally predicting the critical residues on the basis of their interatomic distances. Among nine pairs that fall within a proximity of trafficking. These results point to a new role for ICL/NBD interacting residues in PDR ABC transporters in protein folding and trafficking. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  1. NOAA Climate Data Record (CDR) of Ocean Near Surface Atmospheric Properties, Version 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Ocean Surface Bundle (OSB) Climate Data Record (CDR) consist of three parts: sea surface temperature; near-surface wind speed, air temperature, and specific...

  2. NOAA Climate Data Record (CDR) of Ocean Heat Fluxes, Version 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Ocean Surface Bundle (OSB) Climate Data Record (CDR) consist of three parts: sea surface temperature; near-surface wind speed, air temperature, and specific...

  3. NOAA Climate Data Record (CDR) of Sea Surface Temperature - WHOI, Version 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Ocean Surface Bundle (OSB) Climate Data Record (CDR) consist of three parts: sea surface temperature, near-surface atmospheric properties, and heat fluxes....

  4. NOAA Climate Data Record (CDR) of Total Solar Irradiance (TSI), NRLTSI Version 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This Climate Data Record (CDR) contains total solar irradiance (TSI) as a function of time created with the Naval Research Laboratory model for spectral and total...

  5. NOAA Climate Data Record (CDR) of Solar Spectral Irradiance (SSI), NRLSSI Version 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This Climate Data Record (CDR) contains solar spectral irradiance (SSI) as a function of time and wavelength created with the Naval Research Laboratory model for...

  6. NOAA Climate Data Record (CDR) of Atmospheric Layer Temperatures, Version 3.3

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Atmospheric Layer Temperature Climate Data Record (CDR) dataset is a monthly analysis of the tropospheric and stratospheric data using temperature sounding...

  7. NOAA Climate Data Record (CDR) of Passive Microwave Sea Ice Concentration, Version 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Passive Microwave Sea Ice Concentration Climate Data Record (CDR) dataset is generated using daily gridded brightness temperatures from the Defense...

  8. NOAA Climate Data Record (CDR) of AVHRR Polar Pathfinder Extended (APP-X) Cryosphere

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Climate Data Record (CDR) of the extended AVHRR Polar Pathfinder (APP-x) cryosphere contains 19 geophysical variables over the Arctic and Antarctic for the...

  9. NOAA Climate Data Record (CDR) of Monthly Outgoing Longwave Radiation (OLR), Version 2.2-1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This Climate Data Record (CDR) of monthly mean High Resolution Infrared Radiation Sounder (HIRS) Outgoing Longwave Radiation (OLR) flux at the top of the atmosphere...

  10. NOAA Climate Data Record (CDR) of Daily Outgoing Longwave Radiation (OLR), Version 1.2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This Climate Data Record (CDR) contains the daily mean Outgoing Longwave Radiation (OLR) time series in global 1 degree x 1 degree equal-angle gridded maps spanning...

  11. NOAA Climate Data Record (CDR) of Normalized Difference Vegetation Index (NDVI), Version 4

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains gridded daily Normalized Difference Vegetation Index (NDVI) derived from the NOAA Climate Data Record (CDR) of Advanced Very High Resolution...

  12. NOAA Climate Data Record (CDR) of Northern Hemisphere (NH) Snow Cover Extent (SCE), Version 1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) is a record for the Northern Hemisphere (NH) Snow Cover Extent (SCE) spanning from October 4, 1966 to present, updated monthly...

  13. NOAA Fundamental Climate Data Record (CDR) of AMSU-B and MHS Brightness Temperature, Version 1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Climate Data Record (CDR) of Advanced Microwave Sounding Unit-B (AMSU-B) and Microwave Humidity Sounder (MHS) brightness temperature (Tb) in "window...

  14. NOAA Climate Data Record (CDR) of Passive Microwave Sea Ice Concentration, Version 1.0

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset version has been superseded by version 2. This data set provides a Climate Data Record (CDR) of passive microwave sea ice concentration based on the...

  15. Disulfiram is a potent modulator of multidrug transporter Cdr1p of Candida albicans

    International Nuclear Information System (INIS)

    Shukla, Suneet; Sauna, Zuben E.; Prasad, Rajendra; Ambudkar, Suresh V.

    2004-01-01

    To find novel drugs for effective antifungal therapy in candidiasis, we examined disulfiram, a drug used for the treatment of alcoholism, for its role as a potential modulator of Candida multidrug transporter Cdr1p. We show that disulfiram inhibits the oligomycin-sensitive ATPase activity of Cdr1p and 2.5 mM dithiothreitol reverses this inhibition. Disulfiram inhibited the binding of photoaffinity analogs of both ATP ([α- 32 P]8-azidoATP; IC 50 = 0.76 μM) and drug-substrates ([ 3 H]azidopine and [ 125 I]iodoarylazidoprazosin; IC 50 ∼ 12 μM) to Cdr1p in a concentration-dependent manner, suggesting that it can interact with both ATP and substrate-binding site(s) of Cdr1p. Furthermore, a non-toxic concentration of disulfiram (1 μM) increased the sensitivity of Cdr1p expressing Saccharomyces cerevisiae cells to antifungal agents (fluconazole, miconazole, nystatin, and cycloheximide). Collectively these results demonstrate that disulfiram reverses Cdr1p-mediated drug resistance by interaction with both ATP and substrate-binding sites of the transporter and may be useful for antifungal therapy

  16. SU-E-P-55: The Reaserch of Cervical Cancer Delivered with Constant Dose Rate and Gantry Speed Arc Therapy(CDR-CAS-IMAT) On Conventional Linac

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, R; Bai, W; Chi, Z; Gao, C; Xiaomei, F [The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei (China); Gao, Y [Hebei General Hospital, Shijiazhuang, Hebei (China)

    2015-06-15

    Purpose: Postoperative cervical cancer patients with large target volume and the target shape is concave, treatmented with static intensity-modulated radiotherapy (IMRT) is time consuming. The purpose of this study is to investigate using constant dose rate and gantry speed arc therapy(CDR-CAS-IMAT) on conventional linear accelrator, by comparing with the IMRT technology to evaluate the performance of CDR-CAS-IMAT on postoperative cervical cancer patients. Methods: 18 cervical cancer patients treated with IMRT on Varian 23IX were replanted using CDR-CAS-IMAT. The plans were generated on Oncentra v4.1 planning system, PTV was prescribed to 50.4 Gy in 28 fractions. Plans were evaluated based on the ability to meet the dose volume histogram. The homogeneity index (HI), conformity index (CI) of target volume, the dose of organs at risk, radiation delivery time and monitor units were also compared. SPSS 19.0 software paired T-test analysis was carried out on the two sets of data. Results: Compared with the IMRT plans PTV’s CI (t= 3.85, P =0.001), CTV’s CI, HI, D90, D95, D98, V95, V98, V100 (t=4.21, −3.18, 2.13, 4.65, 7.79, 2.29, 6.00, 2.13, p=0.001, 0.005, 0.049, 0.000, 0.000, 0.035, 0.000, 0.049), and cord D2 and rectum V40 (t=−2.65, −2.47, p= P =0.017, 0.025), and treatment time and MU (t=−36.0, −6.26, P =0.000, 0.000) were better than that of IMRT group. But the IMRT plans in terms of decreasing bladder V50, bowel V30 (t=2.14, 3.00, P =0.048, 0.008) and low dose irradiation volume were superior to that of CDR-CAS-IMAT plans. There were no significant differences in other statistical index. Conclusion: Cervical cancer patients with CDR-CAS-IMAT on Varian Clinical 23IX can get equivalent or superior dose distribution compared with the IMRT technology. IMAT have much less treatment time and MU can reduce the uncertainty factor and patient discomfort in treatment. This work was supported by the Medical Science Foundation of the health department of Hebei

  17. Building the infrastructure to make science metrics more scientific [version 2; referees: 1 approved, 2 approved with reservations

    Directory of Open Access Journals (Sweden)

    Jennifer Lin

    2017-04-01

    Full Text Available Research leaders, policy makers and science strategists need evidence to support decision-making around research funding investment, policy and strategy.  In recent years there has been a rapid expansion in the data sources available that shed light onto aspects of research quality, excellence, use, re-use and attention, and engagement. This is at a time when the modes and routes to share and communicate research findings and data are also changing.    In this opinion piece, we outline a series of considerations and interventions that are needed to ensure that research metric development is accompanied by appropriate scrutiny and governance, to properly support the needs of research assessors and decision-makers, while securing the confidence of the research community. Key among these are: agreed ‘gold standards’ around datasets and methodologies; full transparency around the calculation and derivation of research-related indicators; and a strategy and roadmap to take the discipline of scientific indicators and research assessment to a more robust and sustainable place.

  18. Expression of the CDR1 efflux pump in clinical Candida albicans isolates is controlled by a negative regulatory element

    International Nuclear Information System (INIS)

    Gaur, Naseem Akhtar; Manoharlal, Raman; Saini, Preeti; Prasad, Tulika; Mukhopadhyay, Gauranga; Hoefer, Milan; Morschhaeuser, Joachim; Prasad, Rajendra

    2005-01-01

    Resistance to azole antifungal drugs in clinical isolates of the human fungal pathogen Candida albicans is often caused by constitutive overexpression of the CDR1 gene, which encodes a multidrug efflux pump of the ABC transporter superfamily. To understand the relevance of a recently identified negative regulatory element (NRE) in the CDR1 promoter for the control of CDR1 expression in the clinical scenario, we investigated the effect of mutation or deletion of the NRE on CDR1 expression in two matched pairs of azole-sensitive and resistant clinical isolates of C. albicans. Expression of GFP or lacZ reporter genes from the wild type CDR1 promoter was much higher in the azole-resistant C. albicans isolates than in the azole-susceptible isolates, reflecting the known differences in CDR1 expression in these strains. Deletion or mutation of the NRE resulted in enhanced reporter gene expression in azole-sensitive strains, but did not further increase the already high CDR1 promoter activity in the azole-resistant strains. In agreement with these findings, electrophoretic mobility shift assays showed a reduced binding to the NRE of nuclear extracts from the resistant C. albicans isolates as compared with extracts from the sensitive isolates. These results demonstrate that the NRE is involved in maintaining CDR1 expression at basal levels and that this repression is overcome in azole-resistant clinical C. albicans isolates, resulting in constitutive CDR1 overexpression and concomitant drug resistance

  19. The Dutch Techcentre for Life Sciences: Enabling data-intensive life science research in the Netherlands [version 2; referees: 1 approved, 2 approved with reservations

    Directory of Open Access Journals (Sweden)

    Lars Eijssen

    2016-01-01

    Full Text Available We describe the Data programme of the Dutch Techcentre for Life Sciences (DTL, www.dtls.nl. DTL is a new national organisation in scientific research that facilitates life scientists with technologies and technological expertise in an era where new projects often are data-intensive, multi-disciplinary, and multi-site. It is run as a lean not-for-profit organisation with research organisations (both academic and industrial as paying members. The small staff of the organisation undertakes a variety of tasks that are necessary to perform or support modern academic research, but that are not easily undertaken in a purely academic setting. DTL Data takes care of such tasks related to data stewardship, facilitating exchange of knowledge and expertise, and brokering access to e-infrastructure. DTL also represents the Netherlands in ELIXIR, the European infrastructure for life science data. The organisation is still being fine-tuned and this will continue over time, as it is crucial for this kind of organisation to adapt to a constantly changing environment. However, already being underway for several years, our experiences can benefit researchers in other fields or other countries setting up similar initiatives.

  20. Characterization of the CDR3 structure of the Vβ21 T cell clone in patients with P210(BCR-ABL)-positive chronic myeloid leukemia and B-cell acute lymphoblastic leukemia.

    Science.gov (United States)

    Zha, Xianfeng; Chen, Shaohua; Yang, Lijian; Li, Bo; Chen, Yu; Yan, Xiaojuan; Li, Yangqiu

    2011-10-01

    The clonally expanded T cells identified in most cancer patients that respond to tumor-associated antigen such as P210(BCR-ABL) protein have definite, specific antitumor cytotoxicity. T cell receptor (TCR) Vβ CDR3 repertoire diversity was analyzed in patients with chronic myeloid leukemia (CML) and BCR-ABL(+) B-cell acute lymphoblastic leukemia (B-ALL) by GeneScan. A high frequency of oligoclonal expansion of the TCR Vβ21 subfamily was observed in the peripheral blood of CML and B-ALL patients. These clonally expanded Vβ21 T cells were correlated with the pathophysiologic process of CML. A conserved amino acid motif (SLxxV) was observed within the CDR3 region in only 3 patients with CML. Preferential usage of the Jβ segments was also observed in a minority of patients. The 3-dimensional structures of the CDR3 region containing the same motif or using the same Jβ segment displayed low similarity; on the contrary, the conformation of the CDR3 region containing no conserved motif in some T cell clones was highly similar. In conclusion, our findings indicate a high frequency of TCR Vβ21 subfamily expansion in p210(BCR-ABL)-positive CML and B-ALL patients. The characterization of the CDR3 structure was complex. Regrettably, at this time it was not possible to confirm that the Vβ21 T cell clones were derived from the stimulation of p210(BCR-ABL) protein. Copyright © 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

  1. science

    International Development Research Centre (IDRC) Digital Library (Canada)

    David Spurgeon

    Give us the tools: science and technology for development. Ottawa, ...... altered technical rela- tionships among the factors used in the process of production, and the en- .... to ourselves only the rights of audit and periodic substantive review." If a ...... and destroying scarce water reserves, recreational areas and a generally.

  2. Significant differences in physicochemical properties of human immunoglobulin kappa and lambda CDR3 regions

    Directory of Open Access Journals (Sweden)

    Catherine L Townsend

    2016-09-01

    Full Text Available Antibody variable regions are composed of a heavy and a light chain and in humans there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the focus being on the heavy chain CDR-H3 region. In this paper, we set out to investigate the physicochemical and structural differences between human kappa and lambda light chain CDR regions. We constructed a dataset containing over 29,000 - light chain variable region sequences from IgM-transcribing, newly formed B cells isolated from human bone marrow and peripheral blood. We also used a published human naïve dataset to investigate the CDR-H3 properties of heavy chains paired with kappa and lambda light chains, and probed the Protein Data Bank (PDB to investigate the structural differences between kappa and lambda antibody CDR regions. We found that kappa and lambda light chains have very different CDR physicochemical and structural properties, whereas the heavy chains with which they are paired do not differ significantly. We also observed that the mean CDR3 N nucleotide addition in the kappa, lambda and heavy chain gene rearrangements are correlated within donors, but can differ between donors. This indicates that TdT may work with differing efficiencies between different people, but the same efficiency in the different classes of immunoglobulin chain within one person. We have observed large differences in the physicochemical and structural properties of kappa and lambda light chain CDR regions. This may reflect different roles in the humoral immune response.

  3. Significant Differences in Physicochemical Properties of Human Immunoglobulin Kappa and Lambda CDR3 Regions.

    Science.gov (United States)

    Townsend, Catherine L; Laffy, Julie M J; Wu, Yu-Chang Bryan; Silva O'Hare, Joselli; Martin, Victoria; Kipling, David; Fraternali, Franca; Dunn-Walters, Deborah K

    2016-01-01

    Antibody variable regions are composed of a heavy and a light chain, and in humans, there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the focus being on the heavy chain complementarity-determining region (CDR)-H3 region. In this paper, we set out to investigate the physicochemical and structural differences between human kappa and lambda light chain CDR regions. We constructed a dataset containing over 29,000 light chain variable region sequences from IgM-transcribing, newly formed B cells isolated from human bone marrow and peripheral blood. We also used a published human naïve dataset to investigate the CDR-H3 properties of heavy chains paired with kappa and lambda light chains and probed the Protein Data Bank to investigate the structural differences between kappa and lambda antibody CDR regions. We found that kappa and lambda light chains have very different CDR physicochemical and structural properties, whereas the heavy chains with which they are paired do not differ significantly. We also observed that the mean CDR3 N nucleotide addition in the kappa, lambda, and heavy chain gene rearrangements are correlated within donors but can differ between donors. This indicates that terminal deoxynucleotidyl transferase may work with differing efficiencies between different people but the same efficiency in the different classes of immunoglobulin chain within one person. We have observed large differences in the physicochemical and structural properties of kappa and lambda light chain CDR regions. This may reflect different roles in the humoral immune response.

  4. CLIC CDR - physics and detectors: CLIC conceptual design report.

    Energy Technology Data Exchange (ETDEWEB)

    Berger, E.; Demarteau, M.; Repond, J.; Xia, L.; Weerts, H. (High Energy Physics); (Many)

    2012-02-10

    This report forms part of the Conceptual Design Report (CDR) of the Compact LInear Collider (CLIC). The CLIC accelerator complex is described in a separate CDR volume. A third document, to appear later, will assess strategic scenarios for building and operating CLIC in successive center-of-mass energy stages. It is anticipated that CLIC will commence with operation at a few hundred GeV, giving access to precision standard-model physics like Higgs and top-quark physics. Then, depending on the physics landscape, CLIC operation would be staged in a few steps ultimately reaching the maximum 3 TeV center-of-mass energy. Such a scenario would maximize the physics potential of CLIC providing new physics discovery potential over a wide range of energies and the ability to make precision measurements of possible new states previously discovered at the Large Hadron Collider (LHC). The main purpose of this document is to address the physics potential of a future multi-TeV e{sup +}e{sup -} collider based on CLIC technology and to describe the essential features of a detector that are required to deliver the full physics potential of this machine. The experimental conditions at CLIC are significantly more challenging than those at previous electron-positron colliders due to the much higher levels of beam-induced backgrounds and the 0.5 ns bunch-spacing. Consequently, a large part of this report is devoted to understanding the impact of the machine environment on the detector with the aim of demonstrating, with the example of realistic detector concepts, that high precision physics measurements can be made at CLIC. Since the impact of background increases with energy, this document concentrates on the detector requirements and physics measurements at the highest CLIC center-of-mass energy of 3 TeV. One essential output of this report is the clear demonstration that a wide range of high precision physics measurements can be made at CLIC with detectors which are challenging, but

  5. Cdr2p contributes to fluconazole resistance in Candida dubliniensis clinical isolates.

    LENUS (Irish Health Repository)

    2011-05-01

    The development of resistance to azole antifungals used in the treatment of fungal infections can be a serious medical problem. Here, we investigate the molecular mechanisms associated with reduced susceptibility to fluconazole in clinical isolates of Candida dubliniensis , showing evidence of the trailing growth phenomenon. The changes in membrane sterol composition were studied in the presence of subinhibitory fluconazole concentrations. Despite lanosterol and eburicol accumulating as the most prevalent sterols after fluconazole treatment, these ergosterol precursors still support growth of Candida isolates. The overexpression of ABC transporters was demonstrated by immunoblotting employing specific antibodies against Cdr1p and Cdr2p. The presence of a full-length 170 kDa protein Cdr1p was detected in two isolates, while a truncated form of Cdr1p with the molecular mass of 85 kDa was observed in isolate 966\\/3(2). Notably, Cdr2p was detected in this isolate, and the expression of this transporter was modulated by subinhibitory concentrations of fluconazole. These results suggest that C. dubliniensis can display the trailing growth phenomenon, and such isolates express similar molecular mechanisms like that of fluconazole-resistant isolates and can therefore be associated with recurrent infections.

  6. Hippocampal volume and CDR-SB can predict conversion to dementia in MCI patients

    Directory of Open Access Journals (Sweden)

    João Guilherme Fiorani Borgio

    2012-11-01

    Full Text Available OBJECTIVE: To evaluate the combination of two factors: clinical dementia rating sum of boxes scores (CDR-SB and hippocampal volume (HV as predictors of conversion from mild cognitive impairment (MCI to dementia. METHODS: Twenty-eight individuals (9 normal and 19 with MCI were classified according to their CDR sum of boxes scores into 3 groups. RESULTS: The hippocampal volume was significantly lower in the high-risk group and in those who developed dementia after two years. The rate of conversion was crescent among the three groups. CONCLUSION: We were proposed an additional measurement of the hippocampal volume which may be helpful in the prognosis. However, we noted that the CDR-SB is a method as efficient as neuroimaging to predict dementia with the advantage of being a procedure for low cost and easy implementation, more consistent with public policy.

  7. A Wide Lock-Range Referenceless CDR with Automatic Frequency Acquisition

    OpenAIRE

    Seon-Kyoo Lee; Young-Sang Kim; Hong-June Park; Jae-Yoon Sim

    2011-01-01

    A wide lock-range referenceless CDR circuit is proposed with an automatic tracking of data rate. For efficient frequency acquisition, a DLL-based loop is used with a simple phase/frequency detector to extract 1-bit period of input data stream. The CDR, implemented in a 65 nm CMOS, shows a lock range of 650 Mb/s-to-8 Gb/s and BER of less than 10-12 at 8 Gb/s with low power consumption.

  8. A Wide Lock-Range Referenceless CDR with Automatic Frequency Acquisition

    Directory of Open Access Journals (Sweden)

    Seon-Kyoo Lee

    2011-01-01

    Full Text Available A wide lock-range referenceless CDR circuit is proposed with an automatic tracking of data rate. For efficient frequency acquisition, a DLL-based loop is used with a simple phase/frequency detector to extract 1-bit period of input data stream. The CDR, implemented in a 65 nm CMOS, shows a lock range of 650 Mb/s-to-8 Gb/s and BER of less than 10-12 at 8 Gb/s with low power consumption.

  9. Between Scylla and Charybdis: Delayed mitigation narrows the passage between large-scale CDR and high costs

    Science.gov (United States)

    Strefler, Jessica; Bauer, Nico; Kriegler, Elmar; Popp, Alexander; Giannousakis, Anastasis; Edenhofer, Ottmar

    2018-04-01

    There are major concerns about the sustainability of large-scale deployment of carbon dioxide removal (CDR) technologies. It is therefore an urgent question to what extent CDR will be needed to implement the long term ambition of the Paris Agreement. Here we show that ambitious near term mitigation significantly decreases CDR requirements to keep the Paris climate targets within reach. Following the nationally determined contributions (NDCs) until 2030 makes 2 °C unachievable without CDR. Reducing 2030 emissions by 20% below NDC levels alleviates the trade-off between high transitional challenges and high CDR deployment. Nevertheless, transitional challenges increase significantly if CDR is constrained to less than 5 Gt CO2 a‑1 in any year. At least 8 Gt CO2 a‑1 CDR are necessary in the long term to achieve 1.5 °C and more than 15 Gt CO2 a‑1 to keep transitional challenges in bounds.

  10. Detection of inhibitors of Candida albicans Cdr transporters using a diS-C3(3 fluorescence

    Directory of Open Access Journals (Sweden)

    Joanna eSzczepaniak

    2015-03-01

    Full Text Available Candida albicans is a major cause of opportunistic and life-threatening, systemic fungal infections. Hence new antifungal agents, as well as new methods to treat fungal infections, are still needed. The application of inhibitors of drug-efflux pumps may increase the susceptibility of C. albicans to drugs. We developed a new fluorescence method that allows the in vivo activity evaluation of compounds inhibiting of C. albicans transporters. We show that the potentiometric dye 3,3′-dipropylthiacarbocyanine iodide diS-C3(3 is pumped out by both Cdr1 and Cdr2 transporters. The fluorescence labeling with diS-C3(3 enables a real-time observation of the activity of C. albicans Cdr1 and Cdr2 transporters. We demonstrate that enniatin A and beauvericin show different specificities toward these transporters. Enniatin A inhibits diS-C3(3 efflux by Cdr1 while beauvericin inhibits both Cdr1p and Cdr2p.

  11. Evaluation of Susceptibility of Strains of Candida Albicans Isolated from AIDS Patients to Fluconazole and Determination of CDR2 Resistance Gene in Resistant Strains by RT-PCR Method

    Directory of Open Access Journals (Sweden)

    E Farahbakhsh

    2011-08-01

    Full Text Available Introduction & Objective: Nowadays, opportunistic fungi especially Candida albicans are the most common cause of life-threatening infections in immunodeficiency patients. Increasing Azole-resistant strains of C.albicans are a main problem in human immunodeficiency virus-infected patients. The aim of this study was to evaluate the CDR2 gene in C.albicans azole resistant strains, isolated from AIDS patients with oropharyngeal candidiasis by RT-PCR method. Materials & Methods: The present experimental study was conducted at Tarbiat Modares University of Medical Sciences in 2009. C. albicans isolates from HIV infected patients were identified by standard procedures, including germ tube formation, clamidospor and color of colonies on CHROM agar. At first, susceptibility of C. albicans isolates was assessed by disk diffusion agar technique. Then, CDR2 resistance gene was analyzed by RT-PCR and electrophoresis of the PCR products. Finally, patterns of the resulted bands were compared with standard fluconazole resistant strains. The collected data was analyzed using the SPSS software. Results: The results of drug sensitivity of 66 C. albicans isolates from AIDS patients revealed that 62.6% were susceptible, 8.6% were susceptible-dose dependent (SDD and 28.7% were resistant. In RT-PCR analysis, 6% of patients had the CDR2 gene. Conclusion: The use of phenotypic methods like disk diffusion agar, which is cheaper, along with genotypic methods, like RT-PCR, which provide the possibility of studying the mechanism of drug resistance, is recommended.

  12. Functional human antibody CDR fusions as long-acting therapeutic endocrine agonists.

    Science.gov (United States)

    Liu, Tao; Zhang, Yong; Liu, Yan; Wang, Ying; Jia, Haiqun; Kang, Mingchao; Luo, Xiaozhou; Caballero, Dawna; Gonzalez, Jose; Sherwood, Lance; Nunez, Vanessa; Wang, Danling; Woods, Ashley; Schultz, Peter G; Wang, Feng

    2015-02-03

    On the basis of the 3D structure of a bovine antibody with a well-folded, ultralong complementarity-determining region (CDR), we have developed a versatile approach for generating human or humanized antibody agonists with excellent pharmacological properties. Using human growth hormone (hGH) and human leptin (hLeptin) as model proteins, we have demonstrated that functional human antibody CDR fusions can be efficiently engineered by grafting the native hormones into different CDRs of the humanized antibody Herceptin. The resulting Herceptin CDR fusion proteins were expressed in good yields in mammalian cells and retain comparable in vitro biological activity to the native hormones. Pharmacological studies in rodents indicated a 20- to 100-fold increase in plasma circulating half-life for these antibody agonists and significantly extended in vivo activities in the GH-deficient rat model and leptin-deficient obese mouse model for the hGH and hLeptin antibody fusions, respectively. These results illustrate the utility of antibody CDR fusions as a general and versatile strategy for generating long-acting protein therapeutics.

  13. CLIC Detector Concepts as described in the CDR: Differences between the GEANT4 and Engineering Models

    CERN Document Server

    Elsener, K; Schlatter, D; Siegrist, N

    2011-01-01

    The CLIC_ILD and CLIC_SiD detector concepts as used for the CDR Vol. 2 in 2011 exist both in GEANT4 simulation models and in engineering layout drawings. At this early stage of a conceptual design, there are inevitably differences between these models, which are described in this note.

  14. How Do Scores on the ADAS-Cog, MMSE, and CDR-SOB Correspond?

    Science.gov (United States)

    Balsis, Steve; Benge, Jared F; Lowe, Deborah A; Geraci, Lisa; Doody, Rachelle S

    2015-01-01

    Clinicians and researchers who measure cognitive dysfunction often use the Alzheimer's Disease Assessment Scale--Cognitive Subscale (ADAS-Cog), the Mini-Mental State Examination (MMSE), or the Clinical Dementia Rating scale (CDR-SOB). But, the use of different measures can make it difficult to compare data across patients or studies. What is needed is a simple chart that shows how scores on these three important measures correspond to each other. Using data from 1709 participants from the Alzheimer's Disease Neuroimaging Initiative and item response theory-based statistics, we analyzed how scores on each measure, the ADAS-Cog, the MMSE, and the CDR-SOB, correspond. Results indicated multiple inflections in CDR-SOB and ADAS-Cog scores within a given MMSE score, suggesting that the CDR-SOB and ADAS-Cog are more precise in measuring the severity of cognitive dysfunction than the MMSE. This study shows how scores on these three popular measures of cognitive dysfunction correspond to each other, which is very useful information for both researchers and clinicians.

  15. Theoretical Modeling and Simulation of Phase-Locked Loop (PLL for Clock Data Recovery (CDR

    Directory of Open Access Journals (Sweden)

    Zainab Mohamad Ashari

    2012-01-01

    Full Text Available Modern communication and computer systems require rapid (Gbps, efficient  and large bandwidth data transfers. Agressive scaling of digital integrated systems  allow buses and communication controller circuits to be integrated with the microprocessor on the same chip. The  Peripheral Component Interconnect Express (PCIe protocol handles all communcation between the central processing unit (CPU and hardware devices. PCIe buses require efficient clock data recovery circuits (CDR to recover clock signals embedded in data during transmission. This paper describes the theoretical modeling and simulation of a phase-locked loop (PLL used in a CDR circuit. A simple PLL architecture for a 5 GHz CDR circuit is proposed  and elaborated in this work. Simulations were carried out using a Hardware Description Language, Verilog-AMS. The effect of jitter on the proposed design is also simulated and evaluated in this work. It was found that the proposed design is robust against both input and VCO jitter.ABSTRAK: Sistem komunikasi dan komputer moden memerlukan pemindahan data yang cekap (Gbps, dan bandwidth yang besar. Pengecilan agresif menggunakan teknik sistem digital bersepadu membenarkan bas dan litar pengawal komunikasi disatukan dengan  mikroprocessor dalam cip yang sama. Protokol persisian komponen sambung tara ekspres (PCIe mengendalikan semua komunikasi antara unit pemprosesan pusat (CPU dan peranti perkakasan. Bas PCIe memerlukan litar jam pemulihan data (CDR yang cekap untuk mendapatkan kembali isyarat jam yang tertanam dalam data semasa transmisi. Karya ini menerangkan teori pemodelan dan simulasi gelung fasa terkunci (PLL untuk CDR. Rekabentuk 5 GHz PLL yang mudah telah dicadangkan dalm kertas kerja ini. Simulasi telah dijalankan menggunakan perisian verilog-AMS. Simulasi mengunnakan kesan ketar dalam reka bentuk yang dicadangkan telah dinilai. Reka bentuk yang dicadangkan terbukti teguh mengatasi ganguan ketar di input dan VCO.KEY WORDS

  16. NOAA Climate Data Record (CDR) of Advanced Microwave Sounding Unit (AMSU)-A Brightness Temperature, Version 1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Climate Data Record (CDR) for Advanced Microwave Sounding Unit-A (AMSU-A) brightness temperature in "window channels". The data cover a time period from...

  17. NOAA Climate Data Record (CDR) of SSM/I and SSMIS Microwave Brightness Temperatures, CSU Version 1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) from Colorado State University (CSU) contains brightness temperatures that have been improved and quality-controlled over the...

  18. NOAA Climate Data Record (CDR) of MSU and AMSU-A Mean Layer Temperatures, UAH Version 5.4 (Superseded)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Please note: this dataset has been superseded by a newer version (see below). This version is archived offline by NOAA NCEI. This Climate Data Record (CDR) includes...

  19. NOAA Climate Data Record (CDR) of Cloud Properties from AVHRR Pathfinder Atmospheres - Extended (PATMOS-x), Version 5.3

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) of cloud products was produced by the University of Wisconsin using the AVHRR Pathfinder Atmospheres - Extended (PATMOS-X)...

  20. MESSENGER E/V/H MLA 3/4 CDR/RDR DATA V1.0

    Data.gov (United States)

    National Aeronautics and Space Administration — Abstract ======== This data set consists of the MESSENGER Mercury Laser Altimeter (MLA) Calibrated Data Record (CDR) and Reduced Data Record (RDR) products. The MLA...

  1. NOAA Climate Data Record (CDR) of Zonal Mean Ozone Binary Database of Profiles (BDBP), version 1.0

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) of Zonal Mean Ozone Binary Database of Profiles (BDBP) dataset is a vertically resolved, global, gap-free and zonal mean dataset...

  2. NOAA Climate Data Record (CDR) of SSM/I and SSMIS Microwave Brightness Temperatures, RSS Version 7

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This Version 7 NOAA Fundamental Climate Data Record (CDR) from Remote Sensing Systems (RSS) contains brightness temperatures that have been inter-calibrated and...

  3. 4 Relative Agronomic Effectiveness of Some African Rock.cdr

    African Journals Online (AJOL)

    user

    Phosphate Fertilizers in an Ultisol of Okinawa, Japan. D. E. Dodor. Department of Soil Science, School of Agriculture, College of Basic and Applied Sciences,. University of Ghana, PO Box LG 245, Legon, Ghana. Correspondence: Email; dedodor@ug.edu.gh. Abstract. A greenhouse experiment was conducted to compare ...

  4. PHENIX CDR update: An experiment to be performed at the Brookhaven National Laboratory relativistic heavy ion collider. Revision

    International Nuclear Information System (INIS)

    1994-11-01

    The PHENIX Conceptual Design Report Update (CDR Update) is intended for use together with the Conceptual Design Report (CDR). The CDR Update is a companion document to the CDR, and it describes the collaboration's progress since the CDR was submitted in January 1993. Therefore, this document concentrates on changes, refinements, and decisions that have been made over the past year. These documents together define the baseline PHENIX detector that the collaboration intends to build for operation at RHIC startup. In this chapter the current status of the detector and its motivation are briefly described. In Chapters 2 and 3 the detector and the physics performance are more fully developed. In Chapters 4 through 13 the details of the present design status, the technology choices, and the construction costs and schedules are presented. The physics goals of PHENIX collaboration have remained exactly as they were described in the CDR. Primary among these is the detection of a new phase of matter, the quark-gluon plasma (QGP), and the measurement of its properties. The PHENIX experiment will measure many of the best potential QGP signatures to see if any or all of these physics variables show anomalies simultaneously due to the formation of the QGP

  5. JMBR VOLUME 15 Number 1 JUNE 2016 - correction.cdr

    African Journals Online (AJOL)

    Fineprint

    2016-06-01

    Jun 1, 2016 ... JMBR: A Peer-review Journal of Biomedical Sciences. June 2016, Vol. 15 No. ... Combination therapy, Plasmodium falciparum. Introduction. Multidrug .... JMBR 2016:15(1). 76....Journal of Medicine and Biomedical Research ...

  6. JMBR VOLUME 15 Number 1 JUNE 2016 - correction.cdr

    African Journals Online (AJOL)

    Fineprint

    2016-06-01

    Jun 1, 2016 ... Majority felt that the advantages of dental implants were ... disadvantages of dental implants (table 6). 68.7% of the ... Nigerian media about dental implants. ... social sciences.2003. ... Representative marketing - oriented study.

  7. T cells to a dominant epitope of GAD65 express a public CDR3 motif.

    Science.gov (United States)

    Quinn, Anthony; McInerney, Marcia; Huffman, Donald; McInerney, Brigid; Mayo, Stella; Haskins, Kathryn; Sercarz, Eli

    2006-06-01

    Non-obese diabetic (NOD) mice spontaneously develop autoimmune diabetes, and serve as a model for type 1 diabetes (T1D) and natural autoimmunity. T cell responses to the pancreatic islet antigen glutamic acid decarboxylase 65 (GAD65) can be detected in the spleens of young prediabetic NOD mice, which display a unique MHC class II molecule. Here, we report that a distinct TcR beta chain and CDR3 motif are utilized by all NOD mice in response to a dominant determinant on GAD65, establishing a public repertoire in the spontaneous autoimmunity to an important islet cell antigen. GAD65 530-543 (p530)-reactive T cells preferentially utilize the Vbeta4, Dbeta2.1 and Jbeta2.7 gene segments, with a CDR3 that is characterized by a triad of amino acids, DWG, preceded by a polar residue. In addition, we used CDR3 length spectratyping, CDR3-specific reverse transcriptase-PCR and direct TcR sequencing to show that the TcR beta chain structural patterns associated with p530-specific T cells consistently appeared in the islets of young NOD mice with insulitis, but not in the inflamed islets of streptozotocin-treated C57BL/6 mice, or in inflamed NOD salivary glands. To our knowledge, this is the first report to demonstrate that a public T cell repertoire is used in spontaneous autoimmunity to a dominant self-determinant. These findings suggest that defined clonotypes and repertoires may be preferentially selected in haplotypes predisposed to spontaneous autoimmunity.

  8. The physics benchmark processes for the detector performance studies used in CLIC CDR Volume 3

    CERN Document Server

    Allanach, B.J.; Desch, K.; Ellis, J.; Giudice, G.; Grefe, C.; Kraml, S.; Lastovicka, T.; Linssen, L.; Marschall, J.; Martin, S.P.; Muennich, A.; Poss, S.; Roloff, P.; Simon, F.; Strube, J.; Thomson, M.; Wells, J.D.

    2012-01-01

    This note describes the detector benchmark processes used in volume 3 of the CLIC conceptual design report (CDR), which explores a staged construction and operation of the CLIC accelerator. The goal of the detector benchmark studies is to assess the performance of the CLIC ILD and CLIC SiD detector concepts for different physics processes and at a few CLIC centre-of-mass energies.

  9. Evaluation of PERSIANN-CDR for Meteorological Drought Monitoring over China

    Directory of Open Access Journals (Sweden)

    Hao Guo

    2016-05-01

    Full Text Available In this paper, Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks–Climate Data Record (PERSIANN-CDR is analyzed for the assessment of meteorological drought. The evaluation is conducted over China at 0.5° spatial resolution against a ground-based gridded China monthly Precipitation Analysis Product (CPAP from 1983 to 2014 (32 years. The Standardized Precipitation Index (SPI at various time scales (1 month to 12 months is calculated for detecting drought events. The results show that PERSIANN-CDR depicts similar drought behavior as the ground-based CPAP in terms of capturing the spatial and temporal patterns of drought events over eastern China, where the intensity of gauge networks and the frequency of droughts are high. 6-month SPI shows the best agreement with CPAP in identifying drought months. However, large differences between PERSIANN-CDR and CPAP in depicting drought patterns and identifying specific drought events are found over northwestern China, particularly in Xinjiang and Qinghai-Tibet Plateau region. Factors behind this may be due to the relatively sparse gauge networks, the complicated terrain and the performance of PERSIANN algorithm.

  10. 18jan JChemSci brochure.cdr

    Indian Academy of Sciences (India)

    M Lakshmi Kantam, Institute of Chemical Technology, Mumbai. M Puranik, Hindustan Unilever R&D Centre, Bengaluru. Patel BK, Indian Institute of Technology Guwahati, Guwahati. Rajeev Gupta, University of Delhi, Delhi. Ranjit Biswas, SN Bose National Centre for Basic Sciences, Kolkata. Rakeshwar Bandichhor, Dr.

  11. The Text of a Regional Co-operative Agreement for Research, Development and Training related to Nuclear Science and Technology. Latest Status. Declarations/Reservations

    International Nuclear Information System (INIS)

    1972-01-01

    The text of a Regional Co-operative Agreement for Research, Development and Training Related to Nuclear Science and Technology between the Agency and Member States is reproduced herein for the information of all Members. Section 9 thereof specifies the Members that may become party to it [es

  12. The Text of a Regional Co-operative Agreement for Research, Development and Training related to Nuclear Science and Technology. Latest Status. Declarations/Reservations

    International Nuclear Information System (INIS)

    1972-01-01

    The text of a Regional Co-operative Agreement for Research, Development and Training Related to Nuclear Science and Technology between the Agency and Member States is reproduced herein for the information of all Members. Section 9 thereof specifies the Members that may become party to it

  13. The Text of a Regional Co-operative Agreement for Research, Development and Training related to Nuclear Science and Technology. Latest Status. Declarations/Reservations

    International Nuclear Information System (INIS)

    1972-01-01

    The text of a Regional Co-operative Agreement for Research, Development and Training Related to Nuclear Science and Technology between the Agency and Member States is reproduced herein for the information of all Members. Section 9 thereof specifies the Members that may become party to it [fr

  14. Aiming for long-term, objective-driven science communication in the UK [version 2; referees: 1 approved, 2 approved with reservations

    Directory of Open Access Journals (Sweden)

    Andreas Prokop

    2016-12-01

    Full Text Available Communicating science to wider lay audiences is an increasingly important part of a scientist's remit, and is something that many scientists are keen to embrace. However, based on surveys carried out amongst the UK public, as well as our own experiences in developing and delivering such activities, we believe that they are not always as effective at engaging members of the general public as they could be. In this opinion article we argue that in order to achieve more effective science communication, we need more objective-driven and long-term initiatives. As well as being implemented by the scientists themselves, funding organisations can play an important role in helping to drive such initiatives, and we suggest a list of actionable items that might allow for some of these ideas to be implemented.

  15. Turkish Cloud-Radiation Database (CRD) and Its Application with CDR Bayesian Probability Algorithm

    Science.gov (United States)

    Oztopal, A.; Mugnai, A.; Casella, D.; Formenton, M.; Sano, P.; Sonmez, I.; Sen, Z.; Hsaf Team

    2010-12-01

    ABSTRACT It is rather a very difficult task to determine ground rainfall amounts from few Special Sensor Microwave Imager/Sounder (SSMI/S) channels. Although ground rainfall cannot be observed from the space directly, but knowledge about the cloud physics helps to estimate the amound of ground rainfall. SSMI/S includes so much information about the atmospheric structure, however it cannot provide cloud micro-physical structural information. In such a situation, in the rainfall algorithm, besides the SSMI/S data, it is necessary to incorporate cloud micro-physical properties from an external data source. These properties can be obtained quite simply by the help of Cloud Resolving Model (CRM). Later, in addition to all available data, also micro-physical properties obtained from Radiative Transfer Model (RTM) help to determine the SSMI/S brightness temperatures (Brightness temperatures - TBs), which can then be correlated with Cloud-Radiation Database (CRD) data generation. SSMI/S satellite data and CDR provide a common basis for rainfall prediction procedure through CDR Bayesian probability algorithm, which combines the two sets of data in a scientific manner. The first applications of this algorithm, which is being used up today, is due to various researchers. In this work, in order to establish a reflection of available data processing CDR CRM University of Wisconsin - Non-hydrostatic Modeling System (UW-NMS) model is employed, which is first developed by Prof. Gregory J. Tripoli. It is also used by Turkish Meteorological Service by benefiting from radar network data, and finally 14 simulations are realized in this study. Moreover, one case study is fulfilled by using a 3X3 spatial filtering, and then radar data and result of CDR Bayesian probability algorithm are compared with each other. On 9 September 2009 at 03:40 GMT rainfall event on comparatively flat area matches far better with the retrieval values and hence the spatial rainfall occurrence extent and

  16. BCR CDR3 length distributions differ between blood and spleen and between old and young patients, and TCR distributions can be used to detect myelodysplastic syndrome

    International Nuclear Information System (INIS)

    Pickman, Yishai; Mehr, Ramit; Dunn-Walters, Deborah

    2013-01-01

    Complementarity-determining region 3 (CDR3) is the most hyper-variable region in B cell receptor (BCR) and T cell receptor (TCR) genes, and the most critical structure in antigen recognition and thereby in determining the fates of developing and responding lymphocytes. There are millions of different TCR Vβ chain or BCR heavy chain CDR3 sequences in human blood. Even now, when high-throughput sequencing becomes widely used, CDR3 length distributions (also called spectratypes) are still a much quicker and cheaper method of assessing repertoire diversity. However, distribution complexity and the large amount of information per sample (e.g. 32 distributions of the TCRα chain, and 24 of TCRβ) calls for the use of machine learning tools for full exploration. We have examined the ability of supervised machine learning, which uses computational models to find hidden patterns in predefined biological groups, to analyze CDR3 length distributions from various sources, and distinguish between experimental groups. We found that (a) splenic BCR CDR3 length distributions are characterized by low standard deviations and few local maxima, compared to peripheral blood distributions; (b) healthy elderly people's BCR CDR3 length distributions can be distinguished from those of the young; and (c) a machine learning model based on TCR CDR3 distribution features can detect myelodysplastic syndrome with approximately 93% accuracy. Overall, we demonstrate that using supervised machine learning methods can contribute to our understanding of lymphocyte repertoire diversity. (paper)

  17. BCR CDR3 length distributions differ between blood and spleen and between old and young patients, and TCR distributions can be used to detect myelodysplastic syndrome

    Science.gov (United States)

    Pickman, Yishai; Dunn-Walters, Deborah; Mehr, Ramit

    2013-10-01

    Complementarity-determining region 3 (CDR3) is the most hyper-variable region in B cell receptor (BCR) and T cell receptor (TCR) genes, and the most critical structure in antigen recognition and thereby in determining the fates of developing and responding lymphocytes. There are millions of different TCR Vβ chain or BCR heavy chain CDR3 sequences in human blood. Even now, when high-throughput sequencing becomes widely used, CDR3 length distributions (also called spectratypes) are still a much quicker and cheaper method of assessing repertoire diversity. However, distribution complexity and the large amount of information per sample (e.g. 32 distributions of the TCRα chain, and 24 of TCRβ) calls for the use of machine learning tools for full exploration. We have examined the ability of supervised machine learning, which uses computational models to find hidden patterns in predefined biological groups, to analyze CDR3 length distributions from various sources, and distinguish between experimental groups. We found that (a) splenic BCR CDR3 length distributions are characterized by low standard deviations and few local maxima, compared to peripheral blood distributions; (b) healthy elderly people's BCR CDR3 length distributions can be distinguished from those of the young; and (c) a machine learning model based on TCR CDR3 distribution features can detect myelodysplastic syndrome with approximately 93% accuracy. Overall, we demonstrate that using supervised machine learning methods can contribute to our understanding of lymphocyte repertoire diversity.

  18. From Science Reserves to Sustainable Multiple Uses beyond Earth orbit: Evaluating Issues on the Path towards Balanced Environmental Management on Planetary Bodies

    Science.gov (United States)

    Race, Margaret

    Over the past five decades, our understanding of space beyond Earth orbit has been shaped by a succession of mainly robotic missions whose technologies have enabled scientists to answer diverse science questions about celestial bodies across the solar system. For all that time, exploration has been guided by planetary protection policies and principles promulgated by COSPAR and based on provisions in Article IX of the Outer Space Treaty of 1967. Over time, implementation of the various COSPAR planetary protection policies have sought to avoid harmful forward and backward contamination in order to ensure the integrity of science findings, guide activities on different celestial bodies, and appropriately protect Earth whenever extraterrestrial materials have been returned. The recent increased interest in extending both human missions and commercial activities beyond Earth orbit have prompted discussions in various quarters about the need for updating policies and guidelines to ensure responsible, balanced space exploration and use by all parties, regardless whether activities are undertaken by governmental or non-governmental entities. Already, numerous researchers and workgroups have suggested a range of different ways to manage activities on celestial environments (e.g, wilderness parks, exclusion zones, special regions, claims, national research bases, environmental impact assessments, etc.). While the suggestions are useful in thinking about how to manage future space activities, they are not based on any systematically applied or commonly accepted criteria (scientific or otherwise). In addition, they are borrowed from terrestrial approaches for environmental protection, which may or may not have direct applications to space environments. As noted in a recent COSPAR-PEX workshop (GWU 2012), there are no clear definitions of issues such as harmful contamination, the environment to be protected, or what are considered reasonable activity or impacts for particular

  19. Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop.

    Directory of Open Access Journals (Sweden)

    Gediminas Matulis

    2010-06-01

    Full Text Available Invariant Natural Killer T cells (iNKT are a versatile lymphocyte subset with important roles in both host defense and immunological tolerance. They express a highly conserved TCR which mediates recognition of the non-polymorphic, lipid-binding molecule CD1d. The structure of human iNKT TCRs is unique in that only one of the six complementarity determining region (CDR loops, CDR3beta, is hypervariable. The role of this loop for iNKT biology has been controversial, and it is unresolved whether it contributes to iNKT TCR:CD1d binding or antigen selectivity. On the one hand, the CDR3beta loop is dispensable for iNKT TCR binding to CD1d molecules presenting the xenobiotic alpha-galactosylceramide ligand KRN7000, which elicits a strong functional response from mouse and human iNKT cells. However, a role for CDR3beta in the recognition of CD1d molecules presenting less potent ligands, such as self-lipids, is suggested by the clonal distribution of iNKT autoreactivity. We demonstrate that the human iNKT repertoire comprises subsets of greatly differing TCR affinity to CD1d, and that these differences relate to their autoreactive functions. These functionally different iNKT subsets segregate in their ability to bind CD1d-tetramers loaded with the partial agonist alpha-linked glycolipid antigen OCH and structurally different endogenous beta-glycosylceramides. Using surface plasmon resonance with recombinant iNKT TCRs and different ligand-CD1d complexes, we demonstrate that the CDR3beta sequence strongly impacts on the iNKT TCR affinity to CD1d, independent of the loaded CD1d ligand. Collectively our data reveal a crucial role for CDR3beta for the function of human iNKT cells by tuning the overall affinity of the iNKT TCR to CD1d. This mechanism is relatively independent of the bound CD1d ligand and thus forms the basis of an inherent, CDR3beta dependent functional hierarchy of human iNKT cells.

  20. A Climate-Data Record (CDR) of the "Clear-Sky" Surface Temperature of the Greenland Ice Sheet

    Science.gov (United States)

    Hall, Dorothy K.; Comiso, Josefino C.; DiGirolamo, Nocolo E.; Shuman, Christopher A.

    2011-01-01

    We have developed a climate-data record (CDR) of "clear-sky" ice-surface temperature (IST) of the Greenland Ice Sheet using Moderate-Resolution Imaging Spectroradiometer (MODIS) data. The CDR provides daily and monthly-mean IST from March 2000 through December 2010 on a polar stereographic projection at a resolution of 6.25 km. The CDR is amenable to extension into the future using Visible/Infrared Imager Radiometer Suite (VIIRS) data. Regional "clear-sky" surface temperature increases since the early 1980s in the Arctic, measured using Advanced Very High Resolution Radiometer (AVHRR) infrared data, range from 0.57 +/- 0.02 to 0.72 +/- 0.1 c per decade. Arctic warming has important implications for ice-sheet mass balance because much of the periphery of the Greenland Ice Sheet is already near O C during the melt season, and is thus vulnerable to rapid melting if temperatures continue to increase. An increase in melting of the ice sheet would accelerate sea-level rise, an issue affecting potentially billions of people worldwide. The IST CDR will provide a convenient data set for modelers and for climatologists to track changes of the surface temperature of the ice sheet as a whole and of the individual drainage basins on the ice sheet. The daily and monthly maps will provide information on surface melt as well as "clear-sky" temperature. The CDR will be further validated by comparing results with automatic-weather station data and with satellite-derived surface-temperature products.

  1. A ‘Social Form Of Knowledge’ in Practice: Unofficial Compiling of 1960s Pop Music on CD-R

    Directory of Open Access Journals (Sweden)

    Paul Martin

    2012-01-01

    Full Text Available In this article I explore the ‘unofficial’ (and technically illegal compiling of marginally known 1960s pop records on Compact Disc Recordable (CD-R. I do so by situating it within the proposition by the late Raphael Samuel, that history is ‘social knowledge’ and a practice rather than a profession. I propose that this compiling activity exemplifies this proposition. The core of the paper is centred on a 2007 survey which I conducted via three on-line 1960s music enthusiast discussion forums. I draw on the sixteen responses to demonstrate how the motivations, values and intentions of those respondents engaging in the practice of CD-R compiling are historically and socially centred. In doing so, I seek to problematise the music industry’s undifferentiated condemnation of all copying as theft. I do so by showing how, far from stealing, these CD-R compilers are adding to the musical social knowledge of 1960s pop and rock music. I further situate them within a longer lineage of ‘unofficial listening’ dating back to at least the 1930s. In using the term ‘unofficial’ in both a legal and public historical sense (eg to take issue with a received narrative, I point to wider definitions of what historically has or has not been musically ‘official’ to listen to. I seek also to point to the practice of CD-R compiling as a historical ‘moment’ in technological change, which might otherwise go unremarked upon as the CD-R itself heads towards utilitarian obsolescence. Although, the issues and concepts raised in the paper can be little more than pointed to, it is hoped it might act as one platform for the historical engagement with a subject more commonly discussed in sociological terms. As public historians we should be reflexive and inter-disciplinary and it is with this mind set that this article is written.

  2. The Creative Application of Science, Technology and Work Force Innovations to the Decontamination and Decommissioning of the Plutonium Finishing Plant at the Hanford Nuclear Reservation

    International Nuclear Information System (INIS)

    Charboneau, S.; Klos, B.; Heineman, R.; Skeels, B.; Hopkins, A.

    2006-01-01

    's approach to overcome these challengers are described. Many of the challenges to the D and D work at PFP were met with innovative approaches based on new science and/or technology and many were also based on the creativity and motivation of the work force personnel. (authors)

  3. Ambiguity Function Analysis and Processing for Passive Radar Based on CDR Digital Audio Broadcasting

    Directory of Open Access Journals (Sweden)

    Zhang Qiang

    2015-01-01

    Full Text Available China Digital Radio (CDR broadcasting is a new standard of digital audio broadcasting of FM frequency (87–108 MHz based on our research and development efforts. It is compatible with the frequency spectrum in analog FM radio and satisfies the requirements for smooth transition from analog to digital signal in FM broadcasting in China. This paper focuses on the signal characteristics and processing methods of radio-based passive radar. The signal characteristics and ambiguity function of a passive radar illumination source are analyzed. The adverse effects on the target detection of the side peaks owing to cyclic prefix, the Doppler ambiguity strips because of signal synchronization, and the range of side peaks resulting from the signal discontinuous spectrum are then studied. Finally, methods for suppressing these side peaks are proposed and their effectiveness is verified by simulations.

  4. NOAA Climate Data Record (CDR) of Intersatellite Calibrated Clear-Sky HIRS Channel 12 Brightness Temperature, Version 2.6 (Superseded)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) of Inter-Satellite Calibrated Clear-Sky High Resolution Infrared Radiation Sounder (HIRS) Channel 12 brightness temperatures...

  5. NOAA Climate Data Record (CDR) of Reflectance and Brightness Temperatures from AVHRR Pathfinder Atmospheres - Extended (PATMOS-x), Version 5.3

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) of AVHRR reflectance and brightness temperatures was produced by the University of Wisconsin using the AVHRR Pathfinder...

  6. NOAA Climate Data Record (CDR) of AVHRR Daily and Monthly Aerosol Optical Thickness (AOT) over Global Oceans, Version 3.0

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The product is the aerosol optical thickness (AOT) at 0.63 micron, which is retrieved from NOAA PATMOS-x level-2B orbital radinace and cloud CDR products. The...

  7. NOAA Climate Data Record (CDR) of GPS RO-Calibrated AMSU Channel 7 (Temperatures of Troposphere / Stratosphere, TTS), Version 1.0 (Version Superseded)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Climate Data Records (CDR) for Channel 7 contains Radio Occulation (RO) calibrated brightness temperatures from AMSU-A channel 7 measurements at 54.9 GHz from...

  8. A Climate Data Record (CDR) for the global terrestrial water budget: 1984-2010

    Science.gov (United States)

    Zhang, Yu; Pan, Ming; Sheffield, Justin; Siemann, Amanda L.; Fisher, Colby K.; Liang, Miaoling; Beck, Hylke E.; Wanders, Niko; MacCracken, Rosalyn F.; Houser, Paul R.; Zhou, Tian; Lettenmaier, Dennis P.; Pinker, Rachel T.; Bytheway, Janice; Kummerow, Christian D.; Wood, Eric F.

    2018-01-01

    Closing the terrestrial water budget is necessary to provide consistent estimates of budget components for understanding water resources and changes over time. Given the lack of in situ observations of budget components at anything but local scale, merging information from multiple data sources (e.g., in situ observation, satellite remote sensing, land surface model, and reanalysis) through data assimilation techniques that optimize the estimation of fluxes is a promising approach. Conditioned on the current limited data availability, a systematic method is developed to optimally combine multiple available data sources for precipitation (P), evapotranspiration (ET), runoff (R), and the total water storage change (TWSC) at 0.5° spatial resolution globally and to obtain water budget closure (i.e., to enforce P - ET - R - TWSC = 0) through a constrained Kalman filter (CKF) data assimilation technique under the assumption that the deviation from the ensemble mean of all data sources for the same budget variable is used as a proxy of the uncertainty in individual water budget variables. The resulting long-term (1984-2010), monthly 0.5° resolution global terrestrial water cycle Climate Data Record (CDR) data set is developed under the auspices of the National Aeronautics and Space Administration (NASA) Earth System Data Records (ESDRs) program. This data set serves to bridge the gap between sparsely gauged regions and the regions with sufficient in situ observations in investigating the temporal and spatial variability in the terrestrial hydrology at multiple scales. The CDR created in this study is validated against in situ measurements like river discharge from the Global Runoff Data Centre (GRDC) and the United States Geological Survey (USGS), and ET from FLUXNET. The data set is shown to be reliable and can serve the scientific community in understanding historical climate variability in water cycle fluxes and stores, benchmarking the current climate, and

  9. Expression of cold and drought regulatory protein (CcCDR) of pigeonpea imparts enhanced tolerance to major abiotic stresses in transgenic rice plants.

    Science.gov (United States)

    Sunitha, Mellacheruvu; Srinath, Tamirisa; Reddy, Vudem Dashavantha; Rao, Khareedu Venkateswara

    2017-06-01

    Transgenic rice expressing pigeonpea Cc CDR conferred high-level tolerance to different abiotic stresses. The multiple stress tolerance observed in CcCDR -transgenic lines is attributed to the modulation of ABA-dependent and-independent signalling-pathway genes. Stable transgenic plants expressing Cajanus cajan cold and drought regulatory protein encoding gene (CcCDR), under the control of CaMV35S and rd29A promoters, have been generated in indica rice. Different transgenic lines of CcCDR, when subjected to drought, salt, and cold stresses, exhibited higher seed germination, seedling survival rates, shoot length, root length, and enhanced plant biomass when compared with the untransformed control plants. Furthermore, transgenic plants disclosed higher leaf chlorophyll content, proline, reducing sugars, SOD, and catalase activities, besides lower levels of MDA. Localization studies revealed that the CcCDR-GFP fusion protein was mainly present in the nucleus of transformed cells of rice. The CcCDR transgenics were found hypersensitive to abscisic acid (ABA) and showed reduced seed germination rates as compared to that of control plants. When the transgenic plants were exposed to drought and salt stresses at vegetative and reproductive stages, they revealed larger panicles and higher number of filled grains compared to the untransformed control plants. Under similar stress conditions, the expression levels of P5CS, bZIP, DREB, OsLEA3, and CIPK genes, involved in ABA-dependent and-independent signal transduction pathways, were found higher in the transgenic plants than the control plants. The overall results amply demonstrate that the transgenic rice expressing CcCDR bestows high-level tolerance to drought, salt, and cold stress conditions. Accordingly, the CcCDR might be deployed as a promising candidate gene for improving the multiple stress tolerance of diverse crop plants.

  10. JOPATW~1.cdr 08.cdr

    African Journals Online (AJOL)

    tablets, the mechanism and kinetics of drug delivery were studied. ... different pH environments with a characteristic swelling ratio of 12 and 5 in ... stored in an air tight container and placed in a desiccator until used. ... Tablet physical quality.

  11. JOPATW~1.cdr 08.cdr

    African Journals Online (AJOL)

    4HIV Vaccine Trial Unit, Asokoro District Hospital, Abuja, Nigeria. Abstract ... for patient management and prevention of new infections and a number of test kits by different ... arriving HIV antibody detection assays are dynamic process. ... personnel should not only pay attention to public awareness about HIV/AIDS but.

  12. Are uranium reserves adequate?

    International Nuclear Information System (INIS)

    Anon.

    2006-01-01

    Against a backdrop of growing concerns about global warming and geopolitical pressures on fossil energies, especially natural gas and oil, interest in nuclear power has revived considerably. Conscious of its addiction to oil and reeling from a series of gigantic blackouts, the United States, in the words of its president, must 'aggressively move forward with the construction of nuclear power plants'. Some European countries have approved new power plant construction (Finland and France), while the more reserved ones (Belgium, Germany and Sweden) have begun to show a change in attitude. Asia, meanwhile, is host to the planet's largest number of potential nuclear construction projects in this first half of the 21. century. All these signs point to a sharp rise in uranium consumption, the basic fuel for these plants. But are there enough resources to support a nuclear revival on a planetary scale? The publication of the Red Book on uranium in late May 2006 was an opportunity for Thierry Dujardin, Deputy Director of Science and Development at the OECD's Nuclear Energy Agency, to take stock of resources. He gives his opinion in this paper

  13. Replacing reserve requirements

    OpenAIRE

    Edward J. Stevens

    1993-01-01

    An examination of the fading significance of the Federal Reserve System's reserve requirements and the recent flowering of required clearing balances, a rapidly growing feature of Reserve Bank operations.

  14. Repertoire Analysis of Antibody CDR-H3 Loops Suggests Affinity Maturation Does Not Typically Result in Rigidification

    Directory of Open Access Journals (Sweden)

    Jeliazko R. Jeliazkov

    2018-03-01

    Full Text Available Antibodies can rapidly evolve in specific response to antigens. Affinity maturation drives this evolution through cycles of mutation and selection leading to enhanced antibody specificity and affinity. Elucidating the biophysical mechanisms that underlie affinity maturation is fundamental to understanding B-cell immunity. An emergent hypothesis is that affinity maturation reduces the conformational flexibility of the antibody’s antigen-binding paratope to minimize entropic losses incurred upon binding. In recent years, computational and experimental approaches have tested this hypothesis on a small number of antibodies, often observing a decrease in the flexibility of the complementarity determining region (CDR loops that typically comprise the paratope and in particular the CDR-H3 loop, which contributes a plurality of antigen contacts. However, there were a few exceptions and previous studies were limited to a small handful of cases. Here, we determined the structural flexibility of the CDR-H3 loop for thousands of recent homology models of the human peripheral blood cell antibody repertoire using rigidity theory. We found no clear delineation in the flexibility of naïve and antigen-experienced antibodies. To account for possible sources of error, we additionally analyzed hundreds of human and mouse antibodies in the Protein Data Bank through both rigidity theory and B-factor analysis. By both metrics, we observed only a slight decrease in the CDR-H3 loop flexibility when comparing affinity matured antibodies to naïve antibodies, and the decrease was not as drastic as previously reported. Further analysis, incorporating molecular dynamics simulations, revealed a spectrum of changes in flexibility. Our results suggest that rigidification may be just one of many biophysical mechanisms for increasing affinity.

  15. Mediator Tail Module Is Required for Tac1-Activated CDR1 Expression and Azole Resistance in Candida albicans.

    Science.gov (United States)

    Liu, Zhongle; Myers, Lawrence C

    2017-11-01

    The human fungal pathogen Candida albicans develops drug resistance after long-term exposure to azole drugs in the treatment of chronic candidiasis. Gain-of-function (GOF) mutations in the transcription factor Tac1 and the consequent expression of its targets, drug efflux pumps Cdr1 and Cdr2, are a common mechanism by which C. albicans acquires fluconazole resistance. The mechanism by which GOF mutations hyperactivate Tac1 is currently unknown. Here, we define a transcriptional activation domain (TAD) at the C terminus of Tac1. GOF mutations within the Tac1 TAD, outside the context of full-length Tac1, generally do not enhance its absolute potential as a transcriptional activator. Negative regulation of the Tac1 TAD by the Tac1 middle region is necessary for the activating effect of GOF mutations or fluphenazine to be realized. We have found that full-length Tac1, when hyperactivated by xenobiotics or GOF mutations, facilitates the recruitment of the Mediator coactivator complex to the CDR1 promoter. Azole resistance and the activation of Tac1 target genes, such as CDR1 , are dependent on the Tac1 TAD and subunits of the Mediator tail module. The dependence of different Tac1 target promoters on the Mediator tail module, however, varies widely. Lastly, we show that hyperactivation of Tac1 is correlated with its Mediator-dependent phosphorylation, a potentially useful biomarker for Tac1 hyperactivation. The role of Mediator in events downstream of Tac1 hyperactivation in fluconazole-resistant clinical isolates is complex and provides opportunities and challenges for therapeutic intervention. Copyright © 2017 American Society for Microbiology.

  16. Overcoming the heterologous bias: An in vivo functional analysis of multidrug efflux transporter, CgCdr1p in matched pair clinical isolates of Candida glabrata

    International Nuclear Information System (INIS)

    Puri, Nidhi; Manoharlal, Raman; Sharma, Monika; Sanglard, Dominique; Prasad, Rajendra

    2011-01-01

    Research highlights: → First report to demonstrate an in vivo expression system of an ABC multidrug transporter CgCdr1p of C. glabrata. → First report on the structure and functional characterization of CgCdr1p. → Functional conservation of divergent but typical residues of CgCdr1p. → CgCdr1p elicits promiscuity towards substrates and has a large drug binding pocket with overlapping specificities. -- Abstract: We have taken advantage of the natural milieu of matched pair of azole sensitive (AS) and azole resistant (AR) clinical isolates of Candida glabrata for expressing its major ABC multidrug transporter, CgCdr1p for structure and functional analysis. This was accomplished by tagging a green fluorescent protein (GFP) downstream of ORF of CgCDR1 and integrating the resultant fusion protein at its native chromosomal locus in AS and AR backgrounds. The characterization confirmed that in comparison to AS isolate, CgCdr1p-GFP was over-expressed in AR isolates due to its hyperactive native promoter and the GFP tag did not affect its functionality in either construct. We observed that in addition to Rhodamine 6 G (R6G) and Fluconazole (FLC), a recently identified fluorescent substrate of multidrug transporters Nile Red (NR) could also be expelled by CgCdr1p. Competition assays with these substrates revealed the presence of overlapping multiple drug binding sites in CgCdr1p. Point mutations employing site directed mutagenesis confirmed that the role played by unique amino acid residues critical to ATP catalysis and localization of ABC drug transporter proteins are well conserved in C. glabrata as in other yeasts. This study demonstrates a first in vivo novel system where over-expression of GFP tagged MDR transporter protein can be driven by its own hyperactive promoter of AR isolates. Taken together, this in vivo system can be exploited for the structure and functional analysis of CgCdr1p and similar proteins wherein the arte-factual concerns encountered in using

  17. Overcoming the heterologous bias: An in vivo functional analysis of multidrug efflux transporter, CgCdr1p in matched pair clinical isolates of Candida glabrata

    Energy Technology Data Exchange (ETDEWEB)

    Puri, Nidhi; Manoharlal, Raman; Sharma, Monika [Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067 (India); Sanglard, Dominique [Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne (Switzerland); Prasad, Rajendra, E-mail: rp47jnu@gmail.com [Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067 (India)

    2011-01-07

    Research highlights: {yields} First report to demonstrate an in vivo expression system of an ABC multidrug transporter CgCdr1p of C. glabrata. {yields} First report on the structure and functional characterization of CgCdr1p. {yields} Functional conservation of divergent but typical residues of CgCdr1p. {yields} CgCdr1p elicits promiscuity towards substrates and has a large drug binding pocket with overlapping specificities. -- Abstract: We have taken advantage of the natural milieu of matched pair of azole sensitive (AS) and azole resistant (AR) clinical isolates of Candida glabrata for expressing its major ABC multidrug transporter, CgCdr1p for structure and functional analysis. This was accomplished by tagging a green fluorescent protein (GFP) downstream of ORF of CgCDR1 and integrating the resultant fusion protein at its native chromosomal locus in AS and AR backgrounds. The characterization confirmed that in comparison to AS isolate, CgCdr1p-GFP was over-expressed in AR isolates due to its hyperactive native promoter and the GFP tag did not affect its functionality in either construct. We observed that in addition to Rhodamine 6 G (R6G) and Fluconazole (FLC), a recently identified fluorescent substrate of multidrug transporters Nile Red (NR) could also be expelled by CgCdr1p. Competition assays with these substrates revealed the presence of overlapping multiple drug binding sites in CgCdr1p. Point mutations employing site directed mutagenesis confirmed that the role played by unique amino acid residues critical to ATP catalysis and localization of ABC drug transporter proteins are well conserved in C. glabrata as in other yeasts. This study demonstrates a first in vivo novel system where over-expression of GFP tagged MDR transporter protein can be driven by its own hyperactive promoter of AR isolates. Taken together, this in vivo system can be exploited for the structure and functional analysis of CgCdr1p and similar proteins wherein the arte-factual concerns

  18. Reserving by detailed conditioning on individual claim

    Science.gov (United States)

    Kartikasari, Mujiati Dwi; Effendie, Adhitya Ronnie; Wilandari, Yuciana

    2017-03-01

    The estimation of claim reserves is an important activity in insurance companies to fulfill their liabilities. Recently, reserving method of individual claim have attracted a lot of interest in the actuarial science, which overcome some deficiency of aggregated claim method. This paper explores the Reserving by Detailed Conditioning (RDC) method using all of claim information for reserving with individual claim of liability insurance from an Indonesian general insurance company. Furthermore, we compare it to Chain Ladder and Bornhuetter-Ferguson method.

  19. The engineering design evolution of IFMIF: From CDR to EDA phase

    Energy Technology Data Exchange (ETDEWEB)

    Pérez, Mario, E-mail: mario.perez@ifmif.org

    2015-10-15

    Highlights: • Brief description of International Fusion Materials Irradiation Facility (IFMIF), its background and scope its Engineering Design and Validation Activities (EVEDA) phase. • Description and justification of the main design evolutions from previous phases; and in particular from the baseline described in the “Comprehensive Design Report” (CDR). - Abstract: The International Fusion Materials Irradiation Facility (IFMIF), presently in its Engineering Design and Engineering Validation Activities (EVEDA) phase, started in 2007 under the framework of the Broader Approach (BA) Agreement between Japanese Government and EURATOM. The mandate assigned was to develop an integrated engineering design of IFMIF together with accompanying sub-projects to validate the major technological challenges that included the construction of either full scale prototypes or cleverly devised scaled down facilities, which are essential to reliably face the construction of IFMIF on schedule and cost. The Engineering Design Activities were accomplished on-schedule with the release of its “Intermediate Engineering Design Report (IIEDR)” in June 2013 compliant with our mandate. This paper highlights the design improvements implemented from the previous Conceptual Design Phase.

  20. Intercomparison of PERSIANN-CDR and TRMM-3B42V7 precipitation estimates at monthly and daily time scales

    Science.gov (United States)

    Katiraie-Boroujerdy, Pari-Sima; Akbari Asanjan, Ata; Hsu, Kuo-lin; Sorooshian, Soroosh

    2017-09-01

    In the first part of this paper, monthly precipitation data from Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks-Climate Data Record (PERSIANN-CDR) and Tropical Rainfall Measuring Mission 3B42 algorithm Version 7 (TRMM-3B42V7) are evaluated over Iran using the Generalized Three-Cornered Hat (GTCH) method which is self-sufficient of reference data as input. Climate Data Unit (CRU) is added to the GTCH evaluations as an independent gauge-based dataset thus, the minimum requirement of three datasets for the model is satisfied. To ensure consistency of all datasets, the two satellite products were aggregated to 0.5° spatial resolution, which is the minimum resolution of CRU. The results show that the PERSIANN-CDR has higher Signal to Noise Ratio (SNR) than TRMM-3B42V7 for the monthly rainfall estimation, especially in the northern half of the country. All datasets showed low SNR in the mountainous area of southwestern Iran, as well as the arid parts in the southeast region of the country. Additionally, in order to evaluate the efficacy of PERSIANN-CDR and TRMM-3B42V7 in capturing extreme daily-precipitation amounts, an in-situ rain-gauge dataset collected by the Islamic Republic of the Iran Meteorological Organization (IRIMO) was employed. Given the sparsity of the rain gauges, only 0.25° pixels containing three or more gauges were used for this evaluation. There were 228 such pixels where daily and extreme rainfall from PERSIANN-CDR and TRMM-3B42V7 could be compared. However, TRMM-3B42V7 overestimates most of the intensity indices (correlation coefficients; R between 0.7648-0.8311, Root Mean Square Error; RMSE between 3.29mm/day-21.2mm/5day); PERSIANN-CDR underestimates these extremes (R between 0.6349-0.7791 and RMSE between 3.59mm/day-30.56mm/5day). Both satellite products show higher correlation coefficients and lower RMSEs for the annual mean of consecutive dry spells than wet spells. The results show that TRMM-3B42V7

  1. A Climate-Data Record (CDR) of the "Clear Sky" Surface Temperature of the Greenland Ice Sheet

    Science.gov (United States)

    Hall, Dorothy K.; Comiso, J. C.; DiGirolamo, N. E.; Shuman, C. A.

    2011-01-01

    To quantify the ice-surface temperature (IST) we are developing a climate-data record (CDR) of monthly IST of the Greenland ice sheet, from 1982 to the present using Advanced Very High Resolution Radiometer (AVHRR) and Moderate-Resolution Imaging Spectroradiometer (MODIS) data at 5-km resolution. "Clear-sky" surface temperature increases have been measured from the early 1980s to the early 2000s in the Arctic using AVHRR data, showing increases ranging from 0.57-0.02 (Wang and Key, 2005) to 0.72 0.10 deg C per decade (Comiso, 2006). Arctic warming has implications for ice-sheet mass balance because much of the periphery of the ice sheet is near 0 deg C in the melt season and is thus vulnerable to more extensive melting (Hanna et al., 2008). The algorithm used for this work has a long history of measuring IST in the Arctic with AVHRR (Key and Haefliger, 1992). The data are currently available from 1981 to 2004 in the AVHRR Polar Pathfinder (APP) dataset (Fowler et al., 2000). J. Key1NOAA modified the AVHRR algorithm for use with MODIS (Hall et al., 2004). The MODIS algorithm is now being processed over Greenland. Issues being addressed in the production of the CDR are: time-series bias caused by cloud cover, and cross-calibration between AVHRR and MODIS instruments. Because of uncertainties, time series of satellite ISTs do not necessarily correspond with actual surface temperatures. The CDR will be validated by comparing results with in-situ (see Koenig and Hall, in press) and automatic-weather station data (e.g., Shuman et al., 2001).

  2. Project W-519 CDR supplement: Raw water and electrical services for privatization contractor, AP tank farm operations

    International Nuclear Information System (INIS)

    Parazin, R.J.

    1998-01-01

    This supplement to the Project W-519 Conceptual Design will identify a means to provide RW and Electrical services to serve the needs of the TWRS Privatization Contractor (PC) at AP Tank Farm as directed by DOE-RL. The RW will serve the fire suppression and untreated process water requirements for the PC. The purpose of this CDR supplement is to identify Raw Water (RW) and Electrical service line routes to the TWRS Privatization Contractor (PC) feed delivery tanks, AP-106 and/or AP-108, and establish associated cost impacts to the Project W-519 baseline

  3. HYDROCARBONS RESERVES IN VENEZUELA

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez Cruz, D.J.

    2007-07-01

    Venezuela is an important player in the energy world, because of its hydrocarbons reserves. The process for calculating oil and associated gas reserves is described bearing in mind that 90% of the gas reserves of Venezuela are associated to oil. Likewise, an analysis is made of the oil reserves figures from 1975 to 2003. Reference is also made to inconsistencies found by international experts and the explanations offered in this respect by the Ministry of Energy and Petroleum (MENPET) and Petroleos de Venezuela (PDVSA) regarding the changes that took place in the 1980s. In turn, Hubbert's Law is explained to determine peak production of conventional oil that a reservoir or field will reach, as well as its relationship with remaining reserves. Emphasis is placed on the interest of the United Nations on this topic. The reserves of associated gas are presented along with their relationship with the different crude oils that are produced and with injected gas, as well as with respect to the possible changes that would take place in the latter if oil reserves are revised. Some recommendations are submitted so that the MENPET starts preparing the pertinent policies ruling reserves. (auth)

  4. Skyline Reservation System

    Data.gov (United States)

    US Agency for International Development — Flight reservation application used for in-country flights by USAID and DoS staff in Afghanistan. The application is managed and maintained by the vendor and USAID...

  5. Aplicação da versão brasileira da escala de avaliação clínica da demência (Clinical Dementia Rating - CDR em amostras de pacientes com demência Application of the Brazilian version of the CDR scale in samples of dementia patients

    Directory of Open Access Journals (Sweden)

    Alberto Luiz Grigoli Maia

    2006-06-01

    Full Text Available OBJETIVO: Avaliar a concordância da escala CDR com critérios diagnósticos e mini exame do estado mental (MEEM, e correlação com escala de Blessed, numa amostra de pacientes do sul do Brasil. MÉTODO: A escala foi avaliada em 269 pacientes com doença de Alzheimer (DA, demência vascular e demência questionável num desenho transversal. Os critérios do NINCDS-ADRDA para provável DA e NINDS-AIREN para provável demência vascular foram os padrões-ouro. O MEEM, a escala Blessed para gravidade da demência, o escore isquêmico de Hachinski, e uma bateria de testes cognitivos também foram aplicados. RESULTADOS: A concordância com o padrão-ouro foi boa (kappa=0,73, e com o MEEM em categorias foi moderada (kappa= 0,53. Observou-se correlação significativa da escala CDR com Blessed (r=0,96; p=0,001. Não se observou diferença de escolaridade ou de idade entre as categorias da escala CDR. CONCLUSÃO: A concordância da CDR foi boa para os critérios diagnósticos e moderada para o MEEM. A escala mostrou validade de construto para gravidade de demência. Não se observou impacto da escolaridade sobre este instrumento.OBJECTIVE: The objective of the study was the analysis of agreement between the CDR scale with diagnostic criteria and mini mental state examination (MMSE, as well as correlation with Blessed scale, in a sample of Southern Brazilian patients. METHOD: The CDR scale was cross-sectionaly evaluated in 269 dementia patients Alzheimer’s disease (AD vascular dementia, and questionable. The NINCDS-ADRDA criteria for probable AD and the NINDS-AIREN for probable vascular dementia were the gold standard. The MMSE, the Blessed scale, the Hachinski ischemic score, and a battery of cognitive tests were also applied. RESULTS: The agreement to gold standard was good (kappa=0.73, while to MMSE categorized was moderate (kappa=0.53. A significant correlation with the Blessed scale (r=0.96; p=0.001 was observed. Education and age were similar

  6. US uranium reserves

    International Nuclear Information System (INIS)

    Hansen, M.V.

    1981-01-01

    The current low level of demand, compounded by rapidly rising costs and low prices, has caused a significant reduction in drilling for uranium in the United States, and the trend is likely to continue for a few more years. The effect on uranium reserves will be fewer additions to reserves because less exploration is being done. Further reductions will occur, especially in low-cost reserves, because of increasing costs, continuing depletion through production, and erosion through the high grading of deposits to fulfill previous contractual commitments. During the past several years, it has been necessary to increase the upper reserve cost level twice to compensate for rising costs. Rising costs are reducing the $15 reserves, the cost category corresponding most closely to the present market price, to an insignificant level. An encouraging factor related to US uranium reserves is that the US position internationally, as far as quantity is concerned, is not bad for the longer term. Also, there is a general opinion that US consumers would rather contract for domestic uranium than for foreign because of greater assurance of supply. Still another factor, nearly impossible to assess, is what effect rising costs in other countries will have on their uranium reserves. The annual conferences between the Grand Junction Area Office staff and major uranium companies provide a broad overview of the industry's perception of the future. It is not optimistic for the short term. Many companies are reducing their exploration and mining programs; some are switching to other more marketable mineral commodities, and a few are investing more heavily in foreign ventures. However, there is general optimism for the long term, and many predict a growth in demand in the mid-1980s. If the industry can survive the few lean years ahead, rising prices may restore its viability to former levels

  7. The LapG protein plays a role in Pseudomonas aeruginosa biofilm formation by controlling the presence of the CdrA adhesin on the cell surface

    DEFF Research Database (Denmark)

    Rybtke, Morten; Berthelsen, Jens; Yang, Liang

    2015-01-01

    Pseudomonas aeruginosa is a clinically relevant species involved in biofilm-based chronic infections. We provide evidence that the P. aeruginosa LapG protein functions as a periplasmic protease that can cleave the protein adhesin CdrA off the cell surface, and thereby plays a role in biofilm...... formation and biofilm dispersal. The P. aeruginosa LapG protein is shown to be a functional homolog of the Pseudomonas putida LapG protein which has previously been shown to function as a periplasmic protease that targets the surface adhesin LapA. Transposon mutagenesis and characterization of defined...... and whole-cell protein fractions showed that CdrA was retained in the whole-cell protein fraction when LapG was absent, whereas it was found in the culture supernatant when LapG was present. The finding that CdrA is a target of LapG in P. aeruginosa is surprising because CdrA has no homology to LapA....

  8. Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity

    Science.gov (United States)

    Dunn, Steven M.; Rizkallah, Pierre J.; Baston, Emma; Mahon, Tara; Cameron, Brian; Moysey, Ruth; Gao, Feng; Sami, Malkit; Boulter, Jonathan; Li, Yi; Jakobsen, Bent K.

    2006-01-01

    The mammalian α/β T cell receptor (TCR) repertoire plays a pivotal role in adaptive immunity by recognizing short, processed, peptide antigens bound in the context of a highly diverse family of cell-surface major histocompatibility complexes (pMHCs). Despite the extensive TCR–MHC interaction surface, peptide-independent cross-reactivity of native TCRs is generally avoided through cell-mediated selection of molecules with low inherent affinity for MHC. Here we show that, contrary to expectations, the germ line-encoded complementarity determining regions (CDRs) of human TCRs, namely the CDR2s, which appear to contact only the MHC surface and not the bound peptide, can be engineered to yield soluble low nanomolar affinity ligands that retain a surprisingly high degree of specificity for the cognate pMHC target. Structural investigation of one such CDR2 mutant implicates shape complementarity of the mutant CDR2 contact interfaces as being a key determinant of the increased affinity. Our results suggest that manipulation of germ line CDR2 loops may provide a useful route to the production of high-affinity TCRs with therapeutic and diagnostic potential. PMID:16600963

  9. Systemic Lupus Erythematosus: Molecular Mimicry between Anti-dsDNA CDR3 Idiotype, Microbial and Self Peptides-As Antigens for Th Cells.

    Science.gov (United States)

    Aas-Hanssen, Kristin; Thompson, Keith M; Bogen, Bjarne; Munthe, Ludvig A

    2015-01-01

    Systemic lupus erythematosus (SLE) is marked by a T helper (Th) cell-dependent B cell hyperresponsiveness, with frequent germinal center reactions, and gammaglobulinemia. A feature of SLE is the finding of IgG autoantibodies specific for dsDNA. The specificity of the Th cells that drive the expansion of anti-dsDNA B cells is unresolved. However, anti-microbial, anti-histone, and anti-idiotype Th cell responses have been hypothesized to play a role. It has been entirely unclear if these seemingly disparate Th cell responses and hypotheses could be related or unified. Here, we describe that H chain CDR3 idiotypes from IgG(+) B cells of lupus mice have sequence similarities with both microbial and self peptides. Matched sequences were more frequent within the mutated CDR3 repertoire and when sequences were derived from lupus mice with expanded anti-dsDNA B cells. Analyses of histone sequences showed that particular histone peptides were similar to VDJ junctions. Moreover, lupus mice had Th cell responses toward histone peptides similar to anti-dsDNA CDR3 sequences. The results suggest that Th cells in lupus may have multiple cross-reactive specificities linked to the IgVH CDR3 Id-peptide sequences as well as similar DNA-associated protein motifs.

  10. Handbook on loss reserving

    CERN Document Server

    Schmidt, Klaus; Schnaus, Anja

    2016-01-01

    This handbook presents the basic aspects of actuarial loss reserving. Besides the traditional methods, it also includes a description of more recent ones and a discussion of certain problems occurring in actuarial practice, like inflation, scarce data, large claims, slow loss development, the use of market statistics, the need for simulation techniques and the task of calculating best estimates and ranges of future losses. In property and casualty insurance the provisions for payment obligations from losses that have occurred but have not yet been settled usually constitute the largest item on the liabilities side of an insurer's balance sheet. For this reason, the determination and evaluation of these loss reserves is of considerable economic importance for every property and casualty insurer. Actuarial students, academics as well as practicing actuaries will benefit from this overview of the most important actuarial methods of loss reserving by developing an understanding of the underlying stochastic models...

  11. Lithium reserves and resources

    International Nuclear Information System (INIS)

    Evans, R.K.

    1978-01-01

    As a result of accelerating research efforts in the fields of secondary batteries and thermonuclear power generation, concern has been expressed in certain quarters regarding the availability, in sufficient quantities, of lithium. As part of a recent study by the National Research Council on behalf of the Energy Research and Development Administration, a subpanel was formed to consider the outlook for lithium. Principal areas of concern were reserves, resources and the 'surplus' available for energy applications after allowing for the growth in current lithium applications. Reserves and resources were categorized into four classes ranging from fully proved reserves to resources which are probably dependent upon the marketing of co-products to become economically attractive. Because of the proprietary nature of data on beneficiation and processing recoveries, the tonnages of available lithium are expressed in terms of plant feed. However, highly conservative assumptions have been made concerning mining recoveries and these go a considerable way to accounting for total losses. Western World reserves and resources of all classes are estimated at 10.6 million tonnes Li of which 3.5 million tonnes Li are located in the United States. Current United States capacity, virtually equivalent to Western World capacity, is 4700 tonnes Li and production in 1976 approximated to 3500 tonnes Li. Production for current applications is expected to grow to approx. 10,000 tonnes in year 2000 and 13,000 tonnes a decade later. The massive excess of reserves and resources over that necessary to support conventional requirements has limited the amount of justifiable exploration expenditures; on the last occasion, there was a a major increase in demand (by the USAEA) reserves and capacity were increased rapidly. There are no foreseeable reasons why this shouldn't happen again when the need is clear. (author)

  12. The T-cell receptor beta chain CDR3 region of BV8S1/BJ1S5 transcripts in type 1 diabetes.

    Science.gov (United States)

    Naserke, H E; Durinovic-Bellò, I; Seidel, D; Ziegler, A G

    1996-01-01

    We recently described the T-cell receptor (TCR) beta chain CDR3 motif S-SDRLG-NQPQH (BV8S1-BJ1S5) in an islet-specific T-cell clone (K2.12) from a type 1 diabetic patient (AS). A similar motif (RLGNQ) was also reported in a T-cell clone of non-obese diabetic (NOD) mice by others. In order to determine the frequency of our motif in selected and unselected T-cell populations, we cloned and sequenced the CDR3 region of BV8S1-BJ1S5 transcripts. These transcripts were derived from unstimulated peripheral blood T lymphocytes from two type 1 diabetic patients (AS and FS) and their non-diabetic sibling (WS), as well as from an islet-specific T-cell line of one of the patients. In addition, we compared the structure and composition of the CDR3 region in BV8S1-BJ1S5 transcripts from peripheral blood T cells between the patients and their non-diabetic sibling (>50 sequences each). We found that 30% of the islet-specific T-cell line cDNA clones expressed the entire sequence-motif, whereas it was absent in the clones of unstimulated peripheral blood T cells from both patients and their non-diabetic sibling. The average length of the CDR3 region was shorter in the patients (mean AS 9.9, FS 9.9, versus WS 10.7, p = 0.0037) and the number of inserted nucleotides in N nucleotide addition at the DJ-junction lower (mean AS 3.5, FS 3. 2, versus WS 5.2, P = diabetic sibling. Moreover, the pattern of amino acid usage in the CDR3 region was dissimilar at positions 5 and 6, where polar amino acids predominated in both diabetic siblings. In contrast, basic amino acids are preferentially used at position 5 in the clones of the non-diabetic sibling. These data provide information on the general structure of the TCR(BV8S1-BJ1S5) CDR3 region in type 1 diabetes and may indicate differences in the amino and nucleic acid composition of the TCR beta chain CDR3 region between two type 1 diabetic patients and their non-diabetic sibling.

  13. Brazilian uranium reserves

    International Nuclear Information System (INIS)

    Marques, J.P.M.

    1981-01-01

    Due to a growing demand of electric power to support Brasil's development, the use of nuclear energy will be indispensable. The nuclear fuel cycle for the production of energy, starts with the uranium exploration. The work performed in this field led to the discovery of several deposits in the country, which to-date totalize a reserve of 236,300t of U 308 , ranking Brazil in the 6th place among the nations of the western world holding uranium reserves. (Author) [pt

  14. Session 7: Reserve

    International Nuclear Information System (INIS)

    Bailey, R.; Crockford, G.

    2001-01-01

    The reserve session was devoted to some issues that came up through the workshop, which were grouped into three main areas: The Global Accelerator Network, Problems of stress and how to get organized to minimize them, What should an operations group be responsible for? This paper summarizes the discussions that took place. (author)

  15. SUIKERBOSRAND NATURE RESERVE

    African Journals Online (AJOL)

    reserve, the total length being 66 km with six overnight huts. There are also the BokmakiePie. Nature Troil. and the Cheetah Interpretive Troil. which can be used by day visitors. The former has two loops, one of 10 km and another of 17 km. The. Cheetah Troil. is much shorter and various points of interest are interpreted en ...

  16. School Shootings Stun Reservation

    Science.gov (United States)

    Borja, Rhea R.; Cavanagh, Sean

    2005-01-01

    This article deals with the impact brought by the school shootings at Red Lake Indian Reservation in Minnesota to the school community. A deeply troubled 16-year-old student shot and killed seven other people and himself at a high school. The nation's deadliest school attack since the 1999 slayings at Colorado's suburban Columbine High School took…

  17. Uranium reserves fall: AAEC

    International Nuclear Information System (INIS)

    Anon.

    1982-01-01

    Figures released by the AAEC show that Australia's reasonably assured resources of uranium recoverable at US$80 a kg fell by 5,000 tonnes during 1980-81. Reserves at 30 June 1981 totalled 294,000 tonnes. This represented 17 per cent of the Western World's low cost reasonably assured resources

  18. Effect of the herbal formulation Jianpijiedu on the TCRVβCDR3 repertoire in rats with hepatocellular carcinoma and subjected to food restriction combined with laxative.

    Science.gov (United States)

    Sun, Baoguo; Meng, Jun; Xiang, Ting; Zhang, Lei; Deng, Liuxiang; Chen, Yan; Luo, Haoxuan; Yang, Zhangbin; Chen, Zexiong; Zhang, Shijun

    2016-03-01

    The aim of this study was to investigate the effects of the Chinese herbal formulation Jianpijiedu (JPJD) in a rat model of orthotopic hepatocellular carcinoma (OHC). The tumor-bearing rats underwent food restriction combined with laxative (FRL) treatment in order to model the nutritional and digestive symptoms of patients with hepatocellular carcinoma. In addition, the study aimed to elucidate the effect of JPJD on the T cell receptor Vβ-chain complementarity-determining region 3 (TCRVβCDR3) repertoire and the underlying mechanism. The FRL rat model was established by alternate-day food restriction and the oral administration of Glauber's salt (sodium sulfate), based on which the OHC model was then established. Subsequently, the FRL-OHC induced animals received JPJD or thymopentin-5 (TP5) for 17 days. Differences in the TCRVβCDR3 repertoire in the rat thymus, liver and hepatocellular carcinoma tissues were analyzed by polymerase chain reaction. Compared with the FRL-OHC model animals without any treatment, those treated with JPJD exhibited significantly inhibited hepatocellular carcinoma growth (PSimpsons diversity index (Ds) values and the quasi-Gaussian distribution rate of the TCRVβCDR3 repertoire in the thymus, liver and hepatocellular carcinoma tissues. However, no anti-hepatoma effects were evident in the rats treated with TP5. In addition, TP5 increased the Ds values and the quasi-Gaussian distribution rate of the TCRVβCDR3 repertoire in hepatocellular carcinoma tissues compared with those in the JPJD-treated group. The anti-hepatoma effects of JPJD in FRL-OHC-induced animals may be due to the promotion of the Ds values of the TCRVβCDR3 repertoire.

  19. Science of science.

    Science.gov (United States)

    Fortunato, Santo; Bergstrom, Carl T; Börner, Katy; Evans, James A; Helbing, Dirk; Milojević, Staša; Petersen, Alexander M; Radicchi, Filippo; Sinatra, Roberta; Uzzi, Brian; Vespignani, Alessandro; Waltman, Ludo; Wang, Dashun; Barabási, Albert-László

    2018-03-02

    Identifying fundamental drivers of science and developing predictive models to capture its evolution are instrumental for the design of policies that can improve the scientific enterprise-for example, through enhanced career paths for scientists, better performance evaluation for organizations hosting research, discovery of novel effective funding vehicles, and even identification of promising regions along the scientific frontier. The science of science uses large-scale data on the production of science to search for universal and domain-specific patterns. Here, we review recent developments in this transdisciplinary field. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

  20. Comparison of GPM IMERG, TMPA 3B42 and PERSIANN-CDR satellite precipitation products over Malaysia

    Science.gov (United States)

    Tan, Mou Leong; Santo, Harrif

    2018-04-01

    The launch of the Global Precipitation Measurement (GPM) mission has prompted the assessment of the newly released satellite precipitation products (SPPs) in different parts of the world. This study performed an initial comparison of three GPM IMERG products (IMERG_E, IMERG_L and IMERG_F) with its predecessor, the TMPA 3B42 and 3B42RT products, and a long-term PERSIANN-CDR product over Malaysia. The performance of six SPPs was evaluated using 501 precipitation gauges from 12 March 2014 to 29 February 2016. The annual, seasonal, monthly and daily precipitation measurements were validated using three widely used statistical metrics (CC, RMSE and RB). The precipitation detection capability (POD, FAR and CSI), probability density function (PDF) and the 2014-2015 flood event analysis were also considered in this assessment. The results show that all the SPPs perform well in annual and monthly precipitation measurements. The spatial variability of the total annual precipitation in 2015 is well captured by all six SPPs, with high precipitation amount in southern East Malaysia, and low precipitation amount in the middle part of Peninsular Malaysia. In contrast, all the SPPs show moderate correlation at daily precipitation estimations, with better performance during the northeast monsoon season. The performance of all the SPPs is better in eastern Peninsular Malaysia, but poorer in northern Peninsular Malaysia. All the SPPs have good precipitation detection ability, except the PERSIANN-CDR. All the SPPs underestimate the light (0-1 mm/day) and violent (> 50 mm/day) precipitation classes, but overestimate moderate and heavy (1-50 mm/day) precipitation classes. The IMERG is shown to have a better capability in detecting light precipitation (0-1 mm/day) compared to the other SPPs. The PERSIANN-CDR has the worst performance in capturing all the precipitation classes, with significant underestimation of light precipitation (0-1 mm/day) class and overestimation of moderate and

  1. Efecto e influencia de los certificados de depositos reprogramados (cdr`s) durante 1999-2000 en el mercado ecuatoriano

    OpenAIRE

    Leon Cercado, Alejandra; Triana Villanueva, Milton

    2009-01-01

    Por ser los certificados de depósitos (CDR) instrumentos financieros que surgieron como respuesta a la crisis que experimentó la economía ecuatoriana durante el año 1999, al producirse un alza incontrolable de la cotización del sucre respecto del dólar que desembocó en un nuevo modelo de dolarización y en cuyo proceso también la banca en general se vió afectada con el cierre de varios bancos que presentaban problemas de íliquidez y mala administración de sus recursos, el análisis efectuado de...

  2. Fractional Reserve Banking

    OpenAIRE

    Andreasen, Niels; Bjerregaard, Mads; Lund, Jonas; Olsen, Ove Bitsch; Rasmussen, Andreas Dalgas

    2012-01-01

    Projektet er bygget op omkring kritisk realisme, som er det gennemgående videnskabelige fundament til undersøgelsen af hvilke strukturelle grunde der er til finansiel ustabilitet i Danmark. Projektet går i dybden med Fractional Reserve Banking og incitamentsstrukturen i banksystemet. Vi bevæger os både på det makro- og mikroøkonomiske niveau i analysen. På makro niveau bruger vi den østrigske skole om konjunktur teori (The Positive Theory of the Cycle). På mikro niveau arbejder vi med princip...

  3. In vitro radiographic determination of distances from working length files to root ends comparing Kodak RVG 6000, Schick CDR, and Kodak insight film.

    Science.gov (United States)

    Radel, Robert T; Goodell, Gary G; McClanahan, Scott B; Cohen, Mark E

    2006-06-01

    Previous studies suggest that digital and film-based radiography are similar for endodontic measurements. This study compared the accuracy and acceptability of measured distances from the tips of size #10 and #15 files to molar root apices in cadaver jaw sections using the newly developed Kodak RVG 6000, and the Schick CDR digital systems to digitized Kodak film. Standardized images were taken of files placed 0.5 to 1.5 mm short of true radiographic lengths. Images were imported into Adobe PhotoShop 7.0, thereby blinding observers who measured distances from files to root apices and assessed images for clarity (acceptability). Repeated measures ANOVA and Tukey-Kramer post hoc tests demonstrated that Kodak RVG 6000 images with enhanced contrast produced significantly less measurement error than unenhanced contrast Schick CDR images (p Kodak RVG 6000 system provided the best overall images.

  4. T-cell receptor Vbeta CDR3 oligoclonality frequently occurs in childhood refractory cytopenia (MDS-RC) and severe aplastic anemia

    DEFF Research Database (Denmark)

    Vries, A.C. de; Langerak, A.W.; Verhaaf, B.

    2008-01-01

    (Very) severe acquired aplastic anemia ((v)SAA) and myelodysplastic syndrome (MDS) are rare diseases in childhood. (V)SAA is a bone marrow (BM) failure syndrome characterized by immune-mediated destruction of hematopoietic progenitors. MDS is a malignant clonal stem cell disorder, of which...... the hypoplastic variant is, in case of absence of a cytogenetic clone, difficult to separate from (v)SAA. Recently, studies provided a molecular signature of autoimmunity in adult (v)SAA, by showing oligoclonality based on the length of the TCR Vbeta CDR3 region. We investigated retrospectively the frequency...... and the discriminative value of TCR Vbeta CDR3 oligoclonality in pediatric (v)SAA and MDS patients. Peripheral blood (PB) and/or BM mononuclear cell samples of pediatric patients with (v)SAA (n=38), refractory cytopenia (MDS-RC) (n=28) and 18 controls were analysed via TCR Vbeta heteroduplex PCR analysis of extracted...

  5. Co-operation Agreement for the Promotion of Nuclear Science and Technology in Latin America and the Caribbean (ARCAL). Status list as of 30 September 2002. Signature and ratification. Declarations/reservations made upon signature

    International Nuclear Information System (INIS)

    2002-01-01

    The document reproduces the text of the Co-operation Agreement for the Promotion of Nuclear Science and Technology in Latin America and the Caribbean (ARCAL) which was opened for signature on 25 September 1998 and shall come into force after deposit of the instrument of ratification by ten Member States. It shall remain in force for ten years, and may be extended by periods of five years if the Member States so agree. By 30 September 2002, there were 18 Signatories to the above Agreement

  6. 77 FR 21846 - Reserve Requirements of Depository Institutions: Reserves Simplification

    Science.gov (United States)

    2012-04-12

    ... Requirements of Depository Institutions: Reserves Simplification AGENCY: Board of Governors of the Federal Reserve System. ACTION: Final rule. SUMMARY: The Board is amending Regulation D, Reserve Requirements of Depository Institutions, to simplify the administration of reserve requirements. The final rule creates a...

  7. Transformation of Taiwan’s Reserve Force

    Science.gov (United States)

    2017-01-01

    benefited tremen- dously from their deep knowledge across the range of issues associated with reserve force reforms generally, and reserve force...Penghu Wude Joint Counter Amphibious Exercise [澎湖五德聯信聯合反登陸操演],” 2013. 18 For details on Taiwan’s short-range air defense capabilities, see Kuo Wen ...opinion/national-service-for-the-21st-century Kuo Wen -liang, National Defense Education: Defense Science and Technology [全民國防教育國防科技], Taipei: NWCD

  8. Thermal Analysis of Iodine Satellite (iSAT) from Preliminary Design Review (PDR) to Critical Design Review (CDR)

    Science.gov (United States)

    Mauro, Stephanie

    2016-01-01

    The Iodine Satellite (iSAT) is a 12U cubesat with a primary mission to demonstrate the iodine fueled Hall Effect Thruster (HET) propulsion system. The spacecraft (SC) will operate throughout a one year mission in an effort to mature the propulsion system for use in future applications. The benefit of the HET is that it uses a propellant, iodine, which is easy to store and provides a high thrust-to-mass ratio. This paper will describe the thermal analysis and design of the SC between Preliminary Design Review (PDR) and Critical Design Review (CDR). The design of the satellite has undergone many changes due to a variety of challenges, both before PDR and during the time period discussed in this paper. Thermal challenges associated with the system include a high power density, small amounts of available radiative surface area, localized temperature requirements of the propulsion components, and unknown orbital parameters. The thermal control system is implemented to maintain component temperatures within their respective operational limits throughout the mission, while also maintaining propulsion components at the high temperatures needed to allow gaseous iodine propellant to flow. The design includes heaters, insulation, radiators, coatings, and thermal straps. Currently, the maximum temperatures for several components are near to their maximum operation limit, and the battery is close to its minimum operation limit. Mitigation strategies and planned work to solve these challenges will be discussed.

  9. Status of fossil fuel reserves

    International Nuclear Information System (INIS)

    Laherrere, J.

    2005-01-01

    Reserves represent the sum of past and future productions up to the end of production. In most countries the reserve data of fields are confidential. Therefore, fossil fuel reserves are badly known because the published data are more political than technical and many countries make a confusion between resources and reserves. The cumulated production of fossil fuels represents only between a third and a fifth of the ultimate reserves. The production peak will take place between 2020 and 2050. In the ultimate reserves, which extrapolate the past, the fossil fuels represent three thirds of the overall energy. This document analyses the uncertainties linked with fossil fuel reserves: reliability of published data, modeling of future production, comparison with other energy sources, energy consumption forecasts, reserves/production ratio, exploitation of non-conventional hydrocarbons (tar sands, extra-heavy oils, bituminous shales, coal gas, gas shales, methane in overpressure aquifers, methane hydrates), technology impacts, prices impact, and reserves growth. (J.S.)

  10. 77 FR 66361 - Reserve Requirements of Depository Institutions: Reserves Simplification

    Science.gov (United States)

    2012-11-05

    ... Requirements of Depository Institutions: Reserves Simplification AGENCY: Board of Governors of the Federal... (Reserve Requirements of Depository Institutions) published in the Federal Register on April 12, 2012. The... simplifications related to the administration of reserve requirements: 1. Create a common two-week maintenance...

  11. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    The purpose of this work is to investigate the reduction in location management cost by profiling the subscriber with the sets of call data record (CDR) as inputs for a dynamic network simulation. We propose dynamic intelligent paging using the history of subscribers' behaviour directly from a CDR dataset along ...

  12. Fractional Reserve in Banking System

    OpenAIRE

    Valkonen, Maria

    2016-01-01

    This thesis is aimed to provide understanding of the role of the fractional reserve in the mod-ern banking system worldwide and particularly in Finland. The fractional reserve banking is used worldwide, but the benefits of this system are very disputable. On the one hand, experts say that the fractional reserve is a necessary instrument for the normal business and profit making. On the other hand, sceptics openly criticize the fractional reserve system and blame it for fiat money (money n...

  13. Impact of Forest Reserves on Livelihoods of Fringe Communities...

    African Journals Online (AJOL)

    User

    Kwame Nkrumah University of Science and Technology (KNUST),. Kumasi, Ghana ... The study shows that the communities have little role to play in the management of forest reserves. ..... proximity to Kumasi, the cultural hub of. Ghana.

  14. The vegetation of Malilangwe Wildlife Reserve, south-eastern ...

    African Journals Online (AJOL)

    The vegetation of Malilangwe Wildlife Reserve, south-eastern Zimbabwe. ... African Journal of Range and Forage Science ... Comparisons with other southern African savannas are made, and similarities and differences are discussed.

  15. INCIDENCE.CDR NEW 1.CDR

    African Journals Online (AJOL)

    KEY WORDS: Commercial ... are at far greater risk than the drivers and passengers of. 4 ... Despite the clear evidence of higher ... recall, thus the incidence of accidents is likely to be ..... complete picture of the pattern of injuries which occur.

  16. Evaluation of unique identifiers used as keys to match identical publications in Pure and SciVal – a case study from health science [version 2; referees: 1 approved, 2 approved with reservations

    Directory of Open Access Journals (Sweden)

    Heidi Holst Madsen

    2016-09-01

    Full Text Available Unique identifiers (UID are seen as an effective key to match identical publications across databases or identify duplicates in a database. The objective of the present study is to investigate how well UIDs work as match keys in the integration between Pure and SciVal, based on a case with publications from the health sciences. We evaluate the matching process based on information about coverage, precision, and characteristics of publications matched versus not matched with UIDs as the match keys. We analyze this information to detect errors, if any, in the matching process. As an example we also briefly discuss how publication sets formed by using UIDs as the match keys may affect the bibliometric indicators number of publications, number of citations, and the average number of citations per publication.  The objective is addressed in a literature review and a case study. The literature review shows that only a few studies evaluate how well UIDs work as a match key. From the literature we identify four error types: Duplicate digital object identifiers (DOI, incorrect DOIs in reference lists and databases, DOIs not registered by the database where a bibliometric analysis is performed, and erroneous optical or special character recognition. The case study explores the use of UIDs in the integration between the databases Pure and SciVal. Specifically journal publications in English are matched between the two databases. We find all error types except erroneous optical or special character recognition in our publication sets. In particular the duplicate DOIs constitute a problem for the calculation of bibliometric indicators as both keeping the duplicates to improve the reliability of citation counts and deleting them to improve the reliability of publication counts will distort the calculation of average number of citations per publication. The use of UIDs as a match key in citation linking is implemented in many settings, and the availability of

  17. Iodine-131-labelled CDR grafted monoclonal antibody huA33 metastatic colorectal carcinoma: A case study

    International Nuclear Information System (INIS)

    Thomas, D.L.; Lee, F.T.; Scott, A.M.

    1997-01-01

    Full text: A 58-year-old woman was diagnosed with metastatic colorectal carcinoma two years after initial surgery for sigmoid carcinoma. As part of the staging work-up she was initially referred for a 18 F-FDG PET scan at the PET Centre. FDG PET scans of the abdomen and pelvis demonstrated multiple hepatic lesions, but there was no evidence of disease outside the liver. On the basis of extensive hepatic disease, the patient was scheduled for a laparotomy for insertion of an hepatic artery catheter for chemotherapy. In view of her clinical presentation, the patient was eligible for a Phase 1 trial with 131 l-labelled huA33, and agreed to participate. HuA33 is a humanised CDR-grafted recombinant monoclonal antibody directed against an antigen found on >95 per cent of all colorectal carcinomas, and on small bowel and colonic mucosa. The phase 1 trial is a protein dose escalation study designed to examine the biodistribution, pharmacokinetics, dosimetry and safety profile of huA33, and sequential gamma camera images of the whole body were obtained daily until seven days post infusion. SPECT images were obtained on day 6. Excellent localisation of 131 l-huA33 was seen in hepatic lesions. Calculation of whole body retention and tumour uptake was performed, and pharmacokinetic analysis also undertaken. Biopsies of tumour obtained at surgery were used to quantitate tumour uptake and cellular trafficking of 131 l-huA33. On the basis of this phase 1 study, future therapeutic trials of 131 I-huA33 are planned

  18. Assessing the state of the art in biomedical relation extraction: overview of the BioCreative V chemical-disease relation (CDR) task.

    Science.gov (United States)

    Wei, Chih-Hsuan; Peng, Yifan; Leaman, Robert; Davis, Allan Peter; Mattingly, Carolyn J; Li, Jiao; Wiegers, Thomas C; Lu, Zhiyong

    2016-01-01

    Manually curating chemicals, diseases and their relationships is significantly important to biomedical research, but it is plagued by its high cost and the rapid growth of the biomedical literature. In recent years, there has been a growing interest in developing computational approaches for automatic chemical-disease relation (CDR) extraction. Despite these attempts, the lack of a comprehensive benchmarking dataset has limited the comparison of different techniques in order to assess and advance the current state-of-the-art. To this end, we organized a challenge task through BioCreative V to automatically extract CDRs from the literature. We designed two challenge tasks: disease named entity recognition (DNER) and chemical-induced disease (CID) relation extraction. To assist system development and assessment, we created a large annotated text corpus that consisted of human annotations of chemicals, diseases and their interactions from 1500 PubMed articles. 34 teams worldwide participated in the CDR task: 16 (DNER) and 18 (CID). The best systems achieved an F-score of 86.46% for the DNER task--a result that approaches the human inter-annotator agreement (0.8875)--and an F-score of 57.03% for the CID task, the highest results ever reported for such tasks. When combining team results via machine learning, the ensemble system was able to further improve over the best team results by achieving 88.89% and 62.80% in F-score for the DNER and CID task, respectively. Additionally, another novel aspect of our evaluation is to test each participating system's ability to return real-time results: the average response time for each team's DNER and CID web service systems were 5.6 and 9.3 s, respectively. Most teams used hybrid systems for their submissions based on machining learning. Given the level of participation and results, we found our task to be successful in engaging the text-mining research community, producing a large annotated corpus and improving the results of

  19. Biosphere reserves: Attributes for success.

    Science.gov (United States)

    Van Cuong, Chu; Dart, Peter; Hockings, Marc

    2017-03-01

    Biosphere reserves established under the UNESCO Man and the Biosphere Program aim to harmonise biodiversity conservation and sustainable development. Concerns over the extent to which the reserve network was living up to this ideal led to the development of a new strategy in 1995 (the Seville Strategy) to enhance the operation of the network of reserves. An evaluation of effectiveness of management of the biosphere reserve network was called for as part of this strategy. Expert opinion was assembled through a Delphi Process to identify successful and less successful reserves and investigate common factors influencing success or failure. Ninety biosphere reserves including sixty successful and thirty less successful reserves in 42 countries across all five Man and the Biosphere Program regions were identified. Most successful sites are the post-Seville generation while the majority of unsuccessful sites are pre-Seville that are managed as national parks and have not been amended to conform to the characteristics that are meant to define a biosphere reserve. Stakeholder participation and collaboration, governance, finance and resources, management, and awareness and communication are the most influential factors in the success or failure of the biosphere reserves. For success, the biosphere reserve concept needs to be clearly understood and applied through landscape zoning. Designated reserves then need a management system with inclusive good governance, strong participation and collaboration, adequate finance and human resource allocation and stable and responsible management and implementation. All rather obvious but it is difficult to achieve without commitment to the biosphere reserve concept by the governance authorities. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Design and implementation of land reservation system

    Science.gov (United States)

    Gao, Yurong; Gao, Qingqiang

    2009-10-01

    Land reservation is defined as a land management policy for insuring the government to control primary land market. It requires the government to obtain the land first, according to plan, by purchase, confiscation and exchanging, and then exploit and consolidate the land for reservation. Underlying this policy, it is possible for the government to satisfy and manipulate the needs of land for urban development. The author designs and develops "Land Reservation System for Eastern Lake Development District" (LRSELDD), which deals with the realistic land requirement problems in Wuhan Eastern Lake Development Districts. The LRSELDD utilizes modern technologies and solutions of computer science and GIS to process multiple source data related with land. Based on experiments on the system, this paper will first analyze workflow land reservation system and design the system structure based on its principles, then illustrate the approach of organization and management of spatial data, describe the system functions according to the characteristics of land reservation and consolidation finally. The system is running to serve for current work in Eastern Lake Development Districts. It is able to scientifically manage both current and planning land information, as well as the information about land supplying. We use the LRSELDD in our routine work, and with such information, decisions on land confiscation and allocation will be made wisely and scientifically.

  1. Reserves Represented by Random Walks

    International Nuclear Information System (INIS)

    Filipe, J A; Ferreira, M A M; Andrade, M

    2012-01-01

    The reserves problem is studied through models based on Random Walks. Random walks are a classical particular case in the analysis of stochastic processes. They do not appear only to study reserves evolution models. They are also used to build more complex systems and as analysis instruments, in a theoretical feature, of other kind of systems. In this work by studying the reserves, the main objective is to see and guarantee that pensions funds get sustainable. Being the use of these models considering this goal a classical approach in the study of pensions funds, this work concluded about the problematic of reserves. A concrete example is presented.

  2. Reservation wages and starting wages

    NARCIS (Netherlands)

    van Ophem, H.; Hartog, J.; Berkhout, P.

    2011-01-01

    We analyse a unique data set that combines reservation wage and actually paid wage for a large sample of Dutch recent higher education graduates. On average, accepted wages are almost 8% higher than reservation wages, but there is no fixed proportionality. We find that the difference between

  3. Can Creativity Predict Cognitive Reserve?

    Science.gov (United States)

    Palmiero, Massimiliano; Di Giacomo, Dina; Passafiume, Domenico

    2016-01-01

    Cognitive reserve relies on the ability to effectively cope with aging and brain damage by using alternate processes to approach tasks when standard approaches are no longer available. In this study, the issue if creativity can predict cognitive reserve has been explored. Forty participants (mean age: 61 years) filled out: the Cognitive Reserve…

  4. Cognitive science contributions to decision science.

    Science.gov (United States)

    Busemeyer, Jerome R

    2015-02-01

    This article briefly reviews the history and interplay between decision theory, behavioral decision-making research, and cognitive psychology. The review reveals the increasingly important impact that psychology and cognitive science have on decision science. One of the main contributions of cognitive science to decision science is the development of dynamic models that describe the cognitive processes that underlay the evolution of preferences during deliberation phase of making a decision. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. Securities issues in reserves reporting

    International Nuclear Information System (INIS)

    Legg, M.B.

    1997-01-01

    Securities issues in oil and gas reserves reporting were discussed. Alberta requires specific information regarding important oil and gas properties, plants, facilities and installations. When preparing the reserves report, the following elements are important to consider: (1) the author of the report must be a registered professional engineer or registered professional geologist, (2) the report itself must be an engineering document, (3) the content of the report must be extensive, (4) it should be prepared in accordance with petroleum engineering and evaluation practices, and must include a summary of estimated net reserves

  6. Estimating Foreign Exchange Reserve Adequacy

    Directory of Open Access Journals (Sweden)

    Abdul Hakim

    2013-04-01

    Full Text Available Accumulating foreign exchange reserves, despite their cost and their impacts on other macroeconomics variables, provides some benefits. This paper models such foreign exchange reserves. To measure the adequacy of foreign exchange reserves for import, it uses total reserves-to-import ratio (TRM. The chosen independent variables are gross domestic product growth, exchange rates, opportunity cost, and a dummy variable separating the pre and post 1997 Asian financial crisis. To estimate the risky TRM value, this paper uses conditional Value-at-Risk (VaR, with the help of Glosten-Jagannathan-Runkle (GJR model to estimate the conditional volatility. The results suggest that all independent variables significantly influence TRM. They also suggest that the short and long run volatilities are evident, with the additional evidence of asymmetric effects of negative and positive past shocks. The VaR, which are calculated assuming both normal and t distributions, provide similar results, namely violations in 2005 and 2008.

  7. Shell trips over its reserves

    International Nuclear Information System (INIS)

    Jemain, A.

    2004-01-01

    Some mistakes in the evaluation of the proven reserves of Royal Dutch Shell group, the second world petroleum leader, will oblige the other oil and gas companies to be more transparent and vigilant in the future. The proven reserves ('P90' in petroleum professionals' language) are the most important indicators of the mining patrimony of companies. These strategic data are reported each year in the annual reports of the companies and are examined by the security exchange commission. The evaluation of reserves is perfectly codified by the US energy policy and conservation act and its accountable translation using the FAS 69 standard allows to establish long-term cash-flow forecasts. The revision announced by Shell on January 9 leads to a 20% reduction of its proven reserves. Short paper. (J.S.)

  8. Cognitive Reserve Scale and ageing

    Directory of Open Access Journals (Sweden)

    Irene León

    2016-01-01

    Full Text Available The construct of cognitive reserve attempts to explain why some individuals with brain impairment, and some people during normal ageing, can solve cognitive tasks better than expected. This study aimed to estimate cognitive reserve in a healthy sample of people aged 65 years and over, with special attention to its influence on cognitive performance. For this purpose, it used the Cognitive Reserve Scale (CRS and a neuropsychological battery that included tests of attention and memory. The results revealed that women obtained higher total CRS raw scores than men. Moreover, the CRS predicted the learning curve, short-term and long-term memory, but not attentional and working memory performance. Thus, the CRS offers a new proxy of cognitive reserve based on cognitively stimulating activities performed by healthy elderly people. Following an active lifestyle throughout life was associated with better intellectual performance and positive effects on relevant aspects of quality of life.

  9. Professionalizing the Estonian Reserve Component

    National Research Council Canada - National Science Library

    Everett, William

    1998-01-01

    .... In particular, citizen-soldier reserves can allow nations that do not face immediate external threats, such as Estonia, to meet their security requirements for less money than required by standing forces...

  10. Fractional Reserve Banking: Some Quibbles

    OpenAIRE

    Bagus, Philipp; Howden, David

    2010-01-01

    We explore several unaddressed issues in George Selgin’s (1988) claim that the best monetary system to maintain monetary equilibrium is a fractional reserve free banking one. The claim that adverse clearing balances would limit credit expansion in a fractional reserve free banking system is more troublesome than previously reckoned. Both lengthened clearing periods and interbank agreements render credit expansion unrestrained. “The theory of free banking” confuses increases in money held with...

  11. Sequence similarities of protein kinase substrates and inhibitors with immunoglobulins and model immunoglobulin homologue: cell adhesion molecule from the living fossil sponge Geodia cydonium. Mapping of coherent database similarities and implications for evolution of CDR1 and hypermutation

    Czech Academy of Sciences Publication Activity Database

    Kubrycht, J.; Borecký, Jiří; Souček, P.; Ježek, Petr

    2004-01-01

    Roč. 49, č. 3 (2004), s. 219-246 ISSN 0015-5632 R&D Projects: GA MZd NJ6747 Institutional research plan: CEZ:AV0Z5011922 Keywords : CDR1 * immunoglobulin Subject RIV: EE - Microbiology, Virology Impact factor: 1.034, year: 2004

  12. STEM Summer Academy on the Navajo Reservation

    Science.gov (United States)

    Alexander, C. J.

    2012-12-01

    The US Rosetta Project is the NASA contribution to the International Rosetta Mission, an ESA cornerstone mission to comet Churyumov-Gerasimenko. While the project's outreach efforts span multi-media, and a variety of age and ethnic groups, a special emphasis has been made to find a way to provide meaningful outreach to the reservation communities. Because language preservation is an issue of urgent concern to the reservation communities, and because Rosetta, uniquely among NASA missions, has been named after the notion that keys to missing understanding of elements of the ancient past were found in the language on the original Rosetta stone, the US Rosetta Project has embarked upon outreach with a focus on STEM vocabulary in ancient US languages of the Navajo, Hopi, Ojibwe, and other tribal communities as the project expands. NASA image and science are used and described in the native language, alongside lay English and scientific English curriculum elements. Additionally, science (geology/chemistry/botany/physics) elements drawn from the reservation environment, including geomorphology, geochemistry, soil physics, are included and discussed in the native language as much as possible — with their analogs in other planetary environments (such as Mars). In this paper we will report on the most recent Summer Science Academy [2012], a four week summer course for middle school children, created in collaboration with teachers and administrators in the Chinle Unified School District. The concept of the Academy was initiated in 2011, and the first Academy was conducted shortly thereafter, in June 2011 with 14 children, 3 instructors, and a NASA teacher workshop. The community requested three topics: geology, astronomy, and botany. The 2012 Academy built on the curriculum already developed with more robust field trips, addressed to specific science topics, additional quantitative measurements and activities, with more written material for the cultural components from

  13. Radioactive waste management at the Hanford Reservation

    International Nuclear Information System (INIS)

    Anon.

    1979-01-01

    During some 30 years of plutonium production, the Hanford Reservation has accumulated large quantities of low- and high-level radioactive wastes. The high-level wastes have been stored in underground tanks, and the low-level wastes have been percolated into the soil. In recent years some programs for solidification and separation of the high-level wastes have been initiated. The Hanford waste-management system was studied by a panel of the Committee on Radioactive Waste Management of the National Academy of Sciences. The panel concluded that Hanford waste-management practices were adequate at present and for the immediate future but recommended increased research and development programs related to long-term isolation of the wastes. The panel also considered some alternatives for on-site disposal of the wastes. The Hanford Reservation was originally established for the production of plutonium for military purposes. During more than 30 years of operation, large volumes of high- and low-level radioactive wastes have been accumulated and contained at the site. The Management of these wastes has been the subject of controversy and criticism. To obtain a true technical evaluation of the Hanford waste situation, the Energy Research and Development Administration (now part of the Department of Energy) issued a contract to the National Academy of Sciences and the National Research Councilto conduct an independent review and evaluation of the Hanford waste-management practices and plans. A panel of the Committee on Radioactive Waste Management (CRWM) of the National Academy of Sciences conducted this study between the summer of 1976 and the summer of 1977. This article is a summary of the final report of that panel

  14. Science Programs

    Science.gov (United States)

    Laboratory Delivering science and technology to protect our nation and promote world stability Science & ; Innovation Collaboration Careers Community Environment Science & Innovation Facilities Science Pillars Research Library Science Briefs Science News Science Highlights Lab Organizations Science Programs Applied

  15. Demand as frequency controlled reserve

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Z.; Togeby, M.; OEstergaard, J.

    2008-09-15

    Using demand as frequency controlled reserve (DFR) is an emerging technology which allow demand to participate actively in maintaining the system operation without reducing the energy service delivered to the customer and without need of user interaction. The basic premise is that traditional frequency controlled reserves from power plants and interconnections with neighbouring systems can be costly, slow and not fulfil the need for future power grids with a high share of wind power and fewer central power plants, and an intention to perform flexible operation such as is landing. Electricity demands, on the other hand, have advantages as frequency reserve including fast activation speed, smooth linear activation, low expected costs, and well-dispersed in the distribution grid. The main challenge of DFR is new methods for monitoring the available capacity. This project has investigated the technology of using electricity demands for providing frequency reserve to power systems. Within the project the potential and economy of DFR compatible loads in Denmark has been investigated, control logic has been designed, power system impact has been investigated, potential business models has been evaluated and an implementation strategy has been suggested. The tasks and goals of the project have been successfully accomplished based on which the conclusion and future recommendation are made. This project has developed the DFR technology that enables electricity demands to autonomously disconnect or reconnect to the grid in response to system frequency variations. The developed DFR technology is proved to be a promising technology from several perspectives. Technically, using DFR is feasible to provide reserves and enhance power system frequency control, while fulfilling technical requirements such as linear activation (or reconnection) according to frequency (or time). Environmentally, the DFR technology is pollution free in contrast to traditional reserves from generation

  16. Improved Effectiveness of Reserve Forces During Reserve Duty Training.

    Science.gov (United States)

    Treadaway, Harry H.

    The problem areas of motivation, job enrichment, recruiting, and retention are addressed from the viewpoint of the behavioral scientist. Special attention is given to relating job enrichment and motivation techniques, as successfully demonstrated in industry, to the United State Army Reserve. Research method utilized was a literature review…

  17. Extractive reserves in Brazilian Amazonia

    Energy Technology Data Exchange (ETDEWEB)

    Fearnside, P.M (National Institute for Research in the Amazon, Manaus-Amazonas (Brazil))

    1989-06-01

    In 1985 an opportunity arose for maintaining tracts of Amazonian forest under sustainable use. Brazil's National Council of Rubber Tappers and the Rural Worker's Union proposed the creation of a set of reserves of a new type, called extractive reserves. The first six are being established in one of the Brazilian states most threatened by deforestatation. The creation of extractive reserves grants legal protection to forest land traditionally used by rubber tappers, Brazil-nut gatherers, and other extractivists. The term extrativismo (extractivism) in Brazil refers to removing nontimber forest products, such as latex, resins, and nuts, without felling the trees. Approximately 30 products are collected for commercial sale. Many more types of forest materials are gathered, for example as food and medicines, for the extractivists' own use. The reserve proposal is attractive for several reasons related to social problems. It allows the rubber tappers to continue their livelihood rather than be expelled by deforestation. However, it is unlikely that sufficient land will be set aside as extractive reserves to employ all the tappers. Displaced rubber tappers already swell the ranks of urban slum dwellers in Brazil's Amazonian cities, and they have become refugees to continue their profession in the forests of neighboring countries, such as Bolivia.

  18. Detecting Treatment Group Differences in Alzheimer's Disease Clinical Trials: A Comparison of Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog) and the Clinical Dementia Rating - Sum of Boxes (CDR-SB).

    Science.gov (United States)

    Wessels, A M; Dowsett, S A; Sims, J R

    2018-01-01

    The Alzheimer's Disease Assessment Scale's cognitive subscale (ADAS-Cog) has been widely used as an outcome measure in Alzheimer's Disease (AD) clinical trials. In its original form (ADAS-Cog11), the scale has been used successfully in mild-to-moderate AD dementia populations, but its use is more limited in the study of earlier disease (mild cognitive impairment [MCI] or mild dementia due to AD) owing to lack of appropriate sensitivity of some items. With recent focus on earlier treatment, efforts have focused on the development of more sensitive tools, including the Clinical Dementia Rating-Sum of Boxes (CDR-SB), a global assessment tool to evaluate both cognition and function. The ability of the ADAS-Cog and CDR-SB to detect treatment group differences in the clinical trial environment has not been systematically studied. The aim of this analysis was to compare the utility of these tools in detecting treatment group differences, by reviewing study findings identified through advanced searches of clinicaltrials.gov and Ovid, and press releases and scientific presentations. Findings from placebo-controlled studies of ≥ 6m duration and enrolling >100 participants were included; reporting of both the ADAS-Cog and CDR-SB at endpoint was also a requirement. Of the >300 records identified, 34 studies fulfilled the criteria. There were significant placebo versus active drug group differences based on findings from at least one measure for 14 studies. The ADAS-Cog detected treatment differences more frequently than the CDR-SB. Based on these and previously published findings, the ADAS-Cog appears more useful than the CDR-SB in detecting treatment group differences.

  19. Hydrocarbon Reserves: Abundance or Scarcity

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    IFP and the OAPEC jointly organize a regular international seminar dealing with world oil-related problems appearing in the news. For the first time, this seminar has been opened to oil and gas company specialists, service companies, research centers and independents. This year's theme concerns oil and gas reserves: are they abundant or are we headed towards the shortages announced by some experts? This theme is especially topical in that: oil and gas currently meet two thirds of world energy needs and almost completely dominate the transport sector; the reserves declared by the OAPEC countries account for nearly half of world reserves; the price of a barrel of oil went through the roof in 2004; world energy demand is growing fast and alternative sources of energy are far from ready to take over from oil and gas in the next few decades. Since the reserves correspond to the volume it is technically and economically viable to produce, the seminar has, of course, dealt with the technical and economic questions that arise in connection with exploration and production, but it has also considered changes in the geopolitical context. Presentations by the leading companies of the OAPEC countries and by the IFP group were completed by presentation from the International Energy Agency (IEA), the United States Geological Survey (USGS), the IHS Energy Group, Total and Gaz de France. This document gathers the transparencies of the following presentations: Hydrocarbon reserves in OAPEC members countries: current and future (M. Al-Lababidi); Non OAPEC liquid reserves and production forecasts (Y. Mathieu); World oil and gas resources and production outlook (K. Chew); Global investments in the upstream (F. Birol); Total's policy in the oil and gas sector (C. de Margerie); Gaz de France's policy in the oil and gas sector (J. Abiteboul); NOC/IOC's opportunities in OPEC countries (I. Sandrea); Relationships between companies, countries and investors: How they may impact on the growth

  20. Hydrocarbon Reserves: Abundance or Scarcity

    International Nuclear Information System (INIS)

    2005-01-01

    IFP and the OAPEC jointly organize a regular international seminar dealing with world oil-related problems appearing in the news. For the first time, this seminar has been opened to oil and gas company specialists, service companies, research centers and independents. This year's theme concerns oil and gas reserves: are they abundant or are we headed towards the shortages announced by some experts? This theme is especially topical in that: oil and gas currently meet two thirds of world energy needs and almost completely dominate the transport sector; the reserves declared by the OAPEC countries account for nearly half of world reserves; the price of a barrel of oil went through the roof in 2004; world energy demand is growing fast and alternative sources of energy are far from ready to take over from oil and gas in the next few decades. Since the reserves correspond to the volume it is technically and economically viable to produce, the seminar has, of course, dealt with the technical and economic questions that arise in connection with exploration and production, but it has also considered changes in the geopolitical context. Presentations by the leading companies of the OAPEC countries and by the IFP group were completed by presentation from the International Energy Agency (IEA), the United States Geological Survey (USGS), the IHS Energy Group, Total and Gaz de France. This document gathers the transparencies of the following presentations: Hydrocarbon reserves in OAPEC members countries: current and future (M. Al-Lababidi); Non OAPEC liquid reserves and production forecasts (Y. Mathieu); World oil and gas resources and production outlook (K. Chew); Global investments in the upstream (F. Birol); Total's policy in the oil and gas sector (C. de Margerie); Gaz de France's policy in the oil and gas sector (J. Abiteboul); NOC/IOC's opportunities in OPEC countries (I. Sandrea); Relationships between companies, countries and investors: How they may impact on the growth

  1. Hydrocarbon Reserves: Abundance or Scarcity

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    IFP and the OAPEC jointly organize a regular international seminar dealing with world oil-related problems appearing in the news. For the first time, this seminar has been opened to oil and gas company specialists, service companies, research centers and independents. This year's theme concerns oil and gas reserves: are they abundant or are we headed towards the shortages announced by some experts? This theme is especially topical in that: oil and gas currently meet two thirds of world energy needs and almost completely dominate the transport sector; the reserves declared by the OAPEC countries account for nearly half of world reserves; the price of a barrel of oil went through the roof in 2004; world energy demand is growing fast and alternative sources of energy are far from ready to take over from oil and gas in the next few decades. Since the reserves correspond to the volume it is technically and economically viable to produce, the seminar has, of course, dealt with the technical and economic questions that arise in connection with exploration and production, but it has also considered changes in the geopolitical context. Presentations by the leading companies of the OAPEC countries and by the IFP group were completed by presentation from the International Energy Agency (IEA), the United States Geological Survey (USGS), the IHS Energy Group, Total and Gaz de France. This document gathers the transparencies of the following presentations: Hydrocarbon reserves in OAPEC members countries: current and future (M. Al-Lababidi); Non OAPEC liquid reserves and production forecasts (Y. Mathieu); World oil and gas resources and production outlook (K. Chew); Global investments in the upstream (F. Birol); Total's policy in the oil and gas sector (C. de Margerie); Gaz de France's policy in the oil and gas sector (J. Abiteboul); NOC/IOC's opportunities in OPEC countries (I. Sandrea); Relationships between companies, countries and investors: How they may

  2. Demand as Frequency Controlled Reserve

    DEFF Research Database (Denmark)

    Xu, Zhao; Østergaard, Jacob; Togeby, Mikael

    2011-01-01

    Relying on generation side alone is deemed insufficient to fulfill the system balancing needs for future Danish power system, where a 50% wind penetration is outlined by the government for year 2025. This paper investigates using the electricity demand as frequency controlled reserve (DFR) as a new...... balancing measure, which has a high potential and can provide many advantages. Firstly, the background of the research is reviewed, including conventional power system reserves and the electricity demand side potentials. Subsequently, the control logics and corresponding design considerations for the DFR...

  3. Demand as Frequency Controlled Reserve

    DEFF Research Database (Denmark)

    Xu, Zhao; Togeby, Mikael; Østergaard, Jacob

    This report summaries the research outcomes of the project ‘Demand as Frequency Controlled Reserve (DFR)’, which has received the support from Energinet.dk’s PSO program, Grant no. 2005-2-6380. The objective of this project is to investigate the technology of using electricity demands for providing...

  4. Science and Science Fiction

    Science.gov (United States)

    Oravetz, David

    2005-01-01

    This article is for teachers looking for new ways to motivate students, increase science comprehension, and understanding without using the old standard expository science textbook. This author suggests reading a science fiction novel in the science classroom as a way to engage students in learning. Using science fiction literature and language…

  5. Fadiya & Ojoawo (21).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    (Received: 16 April, 2015; Accepted: 16 June, 2015). Biostratigraphic and ... and buildings) in recent years in various parts of ... the basin after the separation of South American ...... (25.50 – 17.25 m), a maximum flooding surface ... U.S.A. 4 ed.

  6. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    extremities in domestic poultry was a serious problem in the ... brought in to the Poultry Clinic of the Veterinary. Teaching Hospital ... disease. The affected quails that were unable to move eventually died, probably due to inability to access feed and water as described by. McNamee and Smyth (2000). Fig 1:Photograph of a ...

  7. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    the nurses and years of working experience had an impact on their .... home and returned the following night. ... in reading research findings include lack of ... well as involving nursing staff in ... lack of equipment, modern technology and time to.

  8. Valid Journal.cdr

    African Journals Online (AJOL)

    not caused by the tiny population of speakers alone as big languages have ceased to ... that an average native speaker of Yoruba would never concede to the fact that Yoruba ..... What will I eat to forget my benefactors? A sheep doesn't forget ...

  9. December 2010.cdr

    African Journals Online (AJOL)

    Prof

    She had no history of dysmenorrhoea or dyspareunia. her last normal menstrual period was on 21 March. 2007, and she bled for 5 days. She developed cyclical pre-menstrual lower abdominal pain 12 years after menarche. She noticed brownish discharge from the umbilicus which occurred about 12 days of commencing ...

  10. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    were purchased from Bodija market, Ibadan,. Nigeria. TPP was ... field test. After weighing the rats, the tests were th performed on the 26 day of the experiment so as to investigate the ..... declines rapidly in the postnatal mouse neocortex.

  11. march issue.cdr

    African Journals Online (AJOL)

    User

    vessel diseases are the often reported common aetiology in ... heart surgery could not be carryout and the histologic diagnosis ... and the systemic blood pressure reading was120/80. mmHg. ... putaminal infarct with surrounding oedema and.

  12. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    90mmHg6. All the information which included ethnicity, age, marital status, occupation, highest level of education attained, number of drugs taken, number of drugs prescribed, reason for dosage omissions or discontinuation of drugs were obtained ...

  13. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    treating discoloured non-vital teeth as a majority of the population may be unable to afford the alternative treatments like ceramic veneers and crowns. The aim of this study was to compare the efficacy and safety of 35% carbamide peroxide and sodium perborate as intracoronal bleaching agents; with a view to encouraging ...

  14. December 2010.cdr

    African Journals Online (AJOL)

    Prof

    A cross-sectional survey of 1776 adults in Yola, North-East Nigeria was carried out in June 2007. A modified .... of tobacco leaf by native Indians in America while in. Asia; smokeless tobacco is an integral culture of the. South East Asians.

  15. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    INTRODUCTION. Informed consent is an established ethical and legal requirement for most diagnostic and therapeutic ... In some instances, information disclosure to a patient may ... benefits, risks and possible alternatives as well as possible ...

  16. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    (n=132, 31.5%) were in their third decade of life and the mean age was 33 ±. 4.2 years. ... difference with respect to age (p=0.374). Majority (n=249, 59.5%) were in the lower socio-economic class. ... need to strengthen the continuing oral health education programme, and ..... oral health beliefs and attitudes of Chinese in.

  17. map jalahalli.cdr

    Indian Academy of Sciences (India)

    RAJAJINAGAR. TUMKUR ROAD. GORAGUNTE PALYA. PLATINUM CITY. YESVANTPUR. M. E. S. R. O. A. D. ACADEMY. FELLOWS. RESIDENCY. ISRO. APTS. I T Qtrs. CFWRI. Play. Ground. R. IN. G. R. O. A. D. HMT SCHOOL. TUMKUR ROAD. CWB .7 km. 0. YESVANTPUR RAIL WAY STATION.

  18. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    aspirin use, effects of other drugs, liver diseases, uremia, etc. .... processed, and stored in the Weibel-Palade bodies of the ... aggregation tests occur. In patients with .... accumulation of urinary toxins. In most of .... resolves the problem quickly.

  19. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    Aim: To determine the factors affecting the choice of surgery as a future career specialty among medical interns in a regional hospital in ... personal interest and career ambitions . In our setting however, the views of fresh medical ... using Graph pad instat software (2012). P value less than 0.05 was considered significant.

  20. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    environmental sanitation, poor health hygiene, overpopulation and poverty constitute major risk factors to ill-health. Whereas, all these risk factors have been ... lymphadenitis in their study. Yet again, studies by Gupta in India also show that granulomatous lymphadenopathy was the. 2 most common lesions encountered.

  1. Valid Journal.cdr

    African Journals Online (AJOL)

    metaphorically used to capture the essence of “racial turn” which in itself encapsulates .... list and our insistence that the rest should go fell on deaf ears because the Audition was ..... London: James Currency, 1994. Udumukwu, Onyaemachi.

  2. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    ... total antioxidant capacity (TAC) and its relationship with other risk factors like blood pressure and ... High sensitivity CRP, Total antioxidant capacity, chronic. 1. 2. 1. *Oboh ..... Erel O. A novel automated direct measurement method for total ...

  3. Valid Journal.cdr

    African Journals Online (AJOL)

    THE LEADERSHIP QUESTION IN CONTEMPORARY. NIGERIA: A STUDY OF .... honours degree in mathematics, and of course, the young. Onyema. The playwright .... the foreign business puppet, the men in high and low places who seek ...

  4. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    grade fever and anorexia . He had about five episodes a day, each lasting for a few minutes and relieved by applying pressure on the abdomen. There was no history of passage of bulky malodorous stool and no family history of diabetes mellitus. Physical examination revealed a chronically ill looking but alert boy.

  5. December 2010.cdr

    African Journals Online (AJOL)

    Prof

    Smoking has also been associated with more aggressive disease but not with other clinical or biological characterics, particularly CD behaviour. Besides ... essentially normal. Abdomen was soft with mild tenderness in both iliac fossae; bowel sounds were heard and normal. No organomegaly. Rectal examination was also ...

  6. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    and compared with values at initiation of study. There was significant reduction in blood pressure (BP) from .... was done for serial values of the respective parameters monitored over the years. P value < 0.05 was ..... Praga M, Morales E. Renal damage associated with proteinuria. Kidney Int. 2002;62: supl. 82:42-46. 32.

  7. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    (PSA) and its role in cancer screening. Method of Scoring: Respondents who have heard of prostate cancer ... (52.2%) knew it plays a role in male reproduction while 150 (37.3%) were aware that the prostate gland ... remarkable improvement in the level of awareness and knowledge of prostate cancer after a 1 hour health ...

  8. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    body mass index, weight, height, waist circumference, blood pressure and fasting ... high prevalence of total cholesterol dyslipidaemia and low-density ..... Nigerian oil workers with type 2 diabetes ... and in white patients treated for essential.

  9. New draft.cdr

    African Journals Online (AJOL)

    HP USER

    1. & AU Ambursa. 1 . 1Faculty of Veterinary Medicine, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria ... and Preventive Medicine laboratory, Faculty of. Veterinary ... with ruminant offal, including are important risk factors. This may ...

  10. Enarvube & Atedhor (6).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    settlement increased by 1.4% and 1.5% respectively while forest and water decreased by 0.7% and .... forest, while water is composed of streams, rivers .... have shown that urban development is a threat to ... Sokoto-Rima Basin of N.W. Nigeria based .... the Atlantic rainforest region: Consequences for the hydrology of small.

  11. Journal 02.cdr

    African Journals Online (AJOL)

    Stephen

    dynamics. Several factors such as poor education, low personal income, availability of ... strategies are put in place. Studies on ... effects of gluts on the farm, farmer and the industry. .... Heading towards effective egg marketing in West Africa.

  12. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    Nigeria, Department of Veterinary Surgery, University of Abuja, Abuja,. Nigeria. ... avoidance of ventral abdominal contact and refusal to stand on hind limbs ... The need to identify and manage pain in animals has been clearly ... abdominal surgery in animals. ... On the third postoperative day, the frequency of defeacation.

  13. Valid Journal.cdr

    African Journals Online (AJOL)

    Articulation Of Women And Gender Issues In Drama And Theatre ... Dr. (Mrs) Regina Ode & Paul ... the right to initiate divorce proceedings, it has also granted women the right to make ..... altar of greed and or poverty of parents. The girl.

  14. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    contribution of SCA related morbidities to paediatric admissions. This descriptive ... morbidities in children with. SCA were infections (44.1%), vaso-occlusive crisis (29.4%), severe anaemia .... system complications, particularly cerebrovascular ...

  15. march issue.cdr

    African Journals Online (AJOL)

    User

    frequent source of decision-making about health matters and personal care of its members . Family dynamics expect the physician-member of the family to be fully ... treat without distracting emotions .The family set up in developed countries are different from ours. In. Nigeria, extended family members are integrated into the ...

  16. HEALTH STATUS.CDR

    African Journals Online (AJOL)

    option. While child day-care setting is supported to provide opportunities for ... under two-year old children cared for in the home environment in a settlement in the junior staff ..... child's needs because of the far-reaching effects on the physical,.

  17. Journal 02.cdr

    African Journals Online (AJOL)

    Stephen

    In recent years, there has been a great increase in smallholder tomato cultivation in Nigeria and other African countries both as food and as cash crops. In some countries after a few good years,. The incidence and severity of common fungal and viral diseases affecting dry season tomato crop were determined on the tomato ...

  18. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    history of throat pain, hoarseness of the voice and cough, unconscious or sedated patients, patients too ..... acupuncture point. Anaesthesia 2004; 59: 647-. 651. 10. Post-thyroidectomy sorethroat following endotracheal intubation. ANZ J. Surg. 2001;. 71:669-671. 11. Tracheal intubation and sorethroat: a mechanical ...

  19. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    were processed for light and electron. m i c r o s c o p y . ... information exist particularly on the ultrastructural peculiarities .... deeper in the longitudinal ridges than those seen in the ... longitudinal ridges and shallow grooves of the membrane.

  20. Akinsanya (9).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    information on the parasitofauna of other relatives of S filamentosus. ... A large portion of the lagoon is shallow and less than 3.0 m deep. The Lekki lagoon is part ... They were subsequently processed for parasitic examination. Morphological ...

  1. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    of an integrated, cross-sectoral and transboundary approach to zoonotic ..... laboratory capacity for diagnosis. In Africa, ... between countries indicate a likelihood of dual or multiple .... H1N1 virus circulation: a modeling study. Lancet infectious ...

  2. Akinnifesi (1).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    processing temperatures and readily available doping materials. ... not a shallow donor but deep level below the conduction band ... simulations generate information at the microscopic level .... helps to examine the behaviour of defects when.

  3. Valid Journal.cdr

    African Journals Online (AJOL)

    into space in the form of waves similar to those of light and heat. The emergent of ... vehicles conveying atrocities through which the lives of the masses are threatened. .... structures, Eagle on radio pose no treat to an ordinary radio audience ...

  4. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    Nigerian Journal of Clinical Practice. Sept. ... were 4324 (58.4%) males and 3075 (41.6%) females, with a male to female ratio of 1.4:1. Disorders of the .... The most productive workforce group, aged 20 to ... well as empowering of the population, especially the women folk ... corroborated by the studies in Nnewi , with the top.

  5. December 2010.cdr

    African Journals Online (AJOL)

    Prof

    blood pressure discrepancy of greater than 30 mmHg between arms . ... inflammation. Presentations include hypertension, pain over ... unequal arm blood pressure, subclavian bruit and ... and a blood pressure difference of 30mmHg between.

  6. 05 Pavel 03.cdr

    African Journals Online (AJOL)

    User

    showing the ways in which the contents related to the state of subjugation, such as political repressions, forced migration, critique of the rulers, unfortunate national uprisings were all included in the books whose main plot took place in South Africa. Paradoxically, the symbolism of subjugation was accompanied by Polish ...

  7. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    relationship between body mass index and relative plasma viscosity in normal young Nigerian adults. A total of 22 normal undergraduate students (8 male and 14 females) of both sexes and between the ages of 18 and 27 years participated in the study. The age, weight and height of each subject was obtained and BMI was.

  8. Odukoya Abiodun (12).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    CONTAMINATION ASSESSMENT OF TOXIC ELEMENTS IN THE SOIL WITHIN. AND AROUND TWO .... The background value is average crustal values. (Taylor, 1964) in .... This is also confirmed by R- mode factor analysis ..... Application of.

  9. Omafuvbe (18).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    of utilizing BSG (a low cost readily available by-product of brewing) to ensure a sustainable reuse of its bio- resources. ... combustion or anaerobic digestion to biogas, adsorbent .... such as Zinc, Ferrous, Magnesium and Hydrogen ions in the ...

  10. Ukpebor (15).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Liquid chromatography-mass spectrometric conditions were ... environmental quality standards for water (EC,. 2000; EC, 2001). .... Synergi Fusion RP HPLC Column; 150 x 2.0 mm, .... applying a voltage to induce fragmentation into daughter ...

  11. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    To evaluate the level of awareness and acceptability of premarital screening for sickle cell disease amongst .... Table 2 shows the knowledge of sickle cell disease and premarital .... Nigeria, a predominantly islamic region, where religion was a ...

  12. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    7 and various authors have proffered diverse ... includes bio data (age, gender, date of admission); poison ... and water. Hospital Management ... City and demonstrated that the top most ... related to the absence of care givers because of ...

  13. MATERNAL BELIEFS.CDR

    African Journals Online (AJOL)

    1Department of Preventive Dentistry, Lagos University Teaching Hospital, ... parents interviewed believed that teething causes no .... prevalent in Nigeria but also in other parts of the world. 14 .... Ahmed I S, Elton A R, Karrar Z A. Knowledge,.

  14. Valid Journal.cdr

    African Journals Online (AJOL)

    common in Nigeria as captured in the world of the play The Woman in Black. Beyond highlighting ... through social structures such as the family (marriage, tradition, rites and other .... the determination of sex of a child is dependent on the mother. ..... International Conference on Performance held at University of th st. Ibadan ...

  15. Valid Journal.cdr

    African Journals Online (AJOL)

    A call for the rebirth of African culture and religion is borne out of the need. 14. 13 ... as thesis to elicit cultural ingredients that advocate for peaceful co-existence of ..... agent here acts on the psychology of the character. The Igbo cosmology of ...

  16. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    Breast Cancer, war, Female, Undergraduate, Students,. 1. Sambo M.N, Idris S.H, Dahiru I.L , Gobir A.A. Department of Community Medicine, Ahmadu Bello University, Zaria .... Nigeria, South Asia and Brazil. . Knowledge and Practice of Self-breast Examination Among Female Undergraduate Students in a Northern Nigeria ...

  17. Valid Journal.cdr

    African Journals Online (AJOL)

    relation to women's representation in the Nigerian video film .... (India). And that, so many people who do not know how these recurring ... state. She is ritually sacrificed by her husband whose love for money would not let him value the woman who has gone .... “inhuman” show that the battle against gender inequality.

  18. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    ABSTRACT. There is paucity of information on the incidence and haematological changes associated with trypanosome infection in Nigerian fishes. This investigation examined randomly buffy coat and blood smears of Tilapia in the wild by direct microscopy for Trypanosomes and complete haematology were analyzed.

  19. December 2010.cdr

    African Journals Online (AJOL)

    Prof

    local anaesthesia in Edinburgh and demonstrated ..... pre-assessment clinic is an effective aid to proper ... Pain controlled by oral analgesics ... applies to patients that meet the fast tracking criteria ... System related reasons for admission.

  20. Bamgbose (2).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    A decrease in equilibrium swelling ratio of the gel in SDS/TX-100 mixtures was observed with an increase in the ... one of them. Chitosan is biodegradable and .... distilled water, the films were air dried for 24 hrs. ... water gently with filter paper.

  1. December 2010.cdr

    African Journals Online (AJOL)

    Prof

    malnutrition and secondary bacterial infections. World Health ... A total number of 43 children with measles presenting at the National Hospital Abuja, seen over a 40 ..... immune response of Nigerian children Arch Dis. Child 1973; 48: 753-6. World Health Organization. Strategies for reducing global measles mortality Wkly.

  2. Fabiyi (19).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    ecosystems and three shoreline/marine ecosystem; Mangrove, Nypa and ... the inland ecosystem in the western part of the coastal areas around Ogun, Ondo ... Keywords: Ecosystem, Agricultural Produce, Fresh Water Agriculture, Marine ... local and global environmental conditions ( Sahid ...... A National Assessment of the.

  3. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    known. Among the pathogenetic mechanisms of the neurological defects of CML suggested in literature so far, hyperleucocytosis-induced stasis. (hyperviscosity syndrome) appears to be the most predominant .This is said to slow down the circulation through small blood vessels in the brainstem and results in deafness .

  4. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    multiple regressions and histogram distributions. TABLE I: .... made the group most widely varied. Adults' mandibles. Average .... within the bone (Chapnick, 1980; Freitas et al.,. 1994; Mc ... Merkel's cartilage and connections of ... The human.

  5. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    The purpose of this study was to develop an alternative technique for the determination of body .... Exclusion criteria included having stiffness or contracture on any of the .... For this reason, there are no direct studies to use to buttress or refute ...

  6. 6 Assessment.cdr

    African Journals Online (AJOL)

    user

    West African Journal of Applied Ecology, vol. 24(2), 2016: 67–89 ... approach to identify the key process controlling the .... chemical parameters analyzed in this study are presented in ...... Biological Engineers 52(2): 493–496. Leube A., Hirdes ...

  7. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    Test group with reduced gingival bleeding did not have low birth weight deliveries. The 18 low .... February 2011. This was a longitudinal ... undetected multiple pregnancy deliveries ..... Source of fund: No external funding was provided for this ...

  8. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    Clostridium sp (2.42%), Serratia sp (2.42%). Bacterial isolates from the waste workers were essentially similar to those isolated from the dumpsites although the latter were more heavily colonized. The highest bacterial burden was recorded from the top soil samples at Benin Bye-pass dumpsite with a mean viable count of.

  9. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    Having noticed some phenotypic similarities in bacteria isolates from hands or clothings of waste dump workers .... of soil, leacheates, hand and clothing swabs were inoculated onto ... the second eye was left uninoculated to serve as control.

  10. Demand Response Spinning Reserve Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Eto, Joseph H.; Nelson-Hoffman, Janine; Torres, Carlos; Hirth,Scott; Yinger, Bob; Kueck, John; Kirby, Brendan; Bernier, Clark; Wright,Roger; Barat, A.; Watson, David S.

    2007-05-01

    The Demand Response Spinning Reserve project is a pioneeringdemonstration of how existing utility load-management assets can providean important electricity system reliability resource known as spinningreserve. Using aggregated demand-side resources to provide spinningreserve will give grid operators at the California Independent SystemOperator (CAISO) and Southern California Edison (SCE) a powerful, newtool to improve system reliability, prevent rolling blackouts, and lowersystem operating costs.

  11. Gas reserves, discoveries and production

    International Nuclear Information System (INIS)

    Saniere, A.

    2006-01-01

    Between 2000 and 2004, new discoveries, located mostly in the Asia/Pacific region, permitted a 71% produced reserve replacement rate. The Middle East and the offshore sector represent a growing proportion of world gas production Non-conventional gas resources are substantial but are not exploited to any significant extent, except in the United States, where they account for 30% of U.S. gas production. (author)

  12. Uranium reserves and exploration activity

    International Nuclear Information System (INIS)

    Meehan, R.J.

    1975-01-01

    The strategy that ERDA plans to employ regarding resource appraisal is outlined. All types of uranium occurrences will be evaluated as sources of domestic ore reserves. Industry's exploration efforts will be compiled. These data will include information on land acquisition and costs, footage drilled and costs, estimates of exploration activities and expenditures, exploration for non-sandstone deposits, exploration in non-established areas, and foreign exploration plans and costs. Typical data in each of these areas are given

  13. Federal reservation of geothermal resources

    Energy Technology Data Exchange (ETDEWEB)

    Silver, R.M.

    1978-01-01

    Union Oil had developed or was seeking to develop wells on the land in Sonoma County, California in order to produce geothermal steam for generating electricity. The US Attorney General brought a quiet title action pursuant to 21(b) of the Geothermal Steam Act of 1970 to determine whether geothermal resources are included in the mineral reservation under the Homestead Act. The US District Court granted Union Oil's motion to dismiss for failure to state a claim upon which relief may be granted. On appeal, the Ninth Circuit reversed and remanded. In summary, the court concluded on the basis of the legislative history of the Stock-Raising Homestead Act that sources of energy are intended to remain in the government's possession, and the purposes of the Act will be best served by including geothermal resources in the reservation of mineral interests. Noting the strictly agricultural purpose of the Act, the subsurface estate reservation was broadly interpreted, even though title passed to all rights that were not expressly reserved. The court left open on remand the question of estoppel of the government from interfering with private lessees by developing subsurface resources compensation.This is a unique and intriguing decision, as it opens wide the definition of ''mineral interest,'' construing it in the timely terms of a valuable natural resource that may be in great demand for future energy needs. The decision is being appealed to the United States Supreme Court, and it will be interesting to observe whether this liberal interpretation of mineral interests will be upheld.

  14. [Synthesis of reserve polyhydroxyalkanoates by luminescent bacteria].

    Science.gov (United States)

    Boiandin, A N; Kalacheva, G S; Rodicheva, E K; Volova, T G

    2008-01-01

    The ability of marine luminescent bacteria to synthesize polyesters of hydroxycarboxylic acids (polyhydroxyalkanoates, PHA) as reserve macromolecules was studied. Twenty strains from the collection of the luminescent bacteria CCIBSO (WDSM839) of the Institute of Biophysics, Siberian Branch, Russian Academy of Sciences, assigned to different taxa (Photobacterium leiognathi, Ph. phosphoreum, Vibrio harveyi, and V. fischeri) were analyzed. The most productive strains were identified, and the conditions ensuring high polymer yields in batch culture (40-70% of the cell dry mass weight) were determined. The capacity of synthesizing two- and three-component polymers containing hydroxybutyric acid as the main monomer and hydroxyvaleric and hydroxyhexanoic acids was revealed in Ph. leiognathi and V. harveyi strains. The results allow luminescent microorganisms to be regarded as new producers of multicomponent polyhydroxyalkanoates.

  15. Ultrasound in evaluating ovarian reserve

    Directory of Open Access Journals (Sweden)

    Eman Ahmaed Shawky Sabek

    2015-12-01

    Full Text Available The objective of this study was to compare the diagnostic accuracy of transvaginal ultrasound (TVS, as a less invasive technique instead of hormonal assay to evaluate the ovarian reserve. This study included fifty-five females with breast cancer and we compared the ovarian reserve for these patients by hormonal assay through measuring the serum AntiMullerian Hormone (AMH level and follicular stimulating hormone (FSH level before and after chemotherapy, and by transvaginal ultrasound through the ovarian volume (OV calculation and counting the Antral follicles (AFC before and after chemotherapy treatment. There was decline in the AntiMullerian Hormone level after chemotherapy by 27 ± 11.19% and decrease in the Antral follicle counts by 21 ± 13.43%. In conclusion there was strong relation between AMH level and AFC which makes the use of transvaginal ultrasound is a reliable alternative method to the hormonal assay to detect the ovarian reserve.

  16. Foreign Exchange Reserves: Bangladesh Perspective

    Directory of Open Access Journals (Sweden)

    Md Zahangir Alam

    2013-10-01

    Full Text Available This study is about foreign exchangereserves of Bangladesh. The mainpurpose of this study is to the influence of exchange rates on foreign exchangereserves to the Bangladesh context.  Both the primary and secondary data has been used inthis study. The primary data has been collected through a structuredquestionnaire from 50 respondents. The secondary data, namely Bangladeshforeign exchange reserves (FER, Bangladesh current account balance (CAB,Bangladesh capital andfinancial account balance (CFAB, and BDT/USD exchange rates (ER.  This study covers yearly data from July 01,1996 to June 30, 2005 and quarterly data from July 01, 2005 to June 30, 2012. Findingsof this study shows that out of the selected 16 factors affecting foreignexchange reserves, exchange rates occupy the first position, weighted averagescore (WAS being 4.56. Foreign exchange reserves (FER and current accountbalance (CAB have increased by 502.9087% and 1451.218%,whereas capital and financial account (CFAB has decreased by -649.024% on June30, 2012 compared to June 30, 1997. The influence of other factors heldconstant, as ER changes by 285.6894 units due to one unit change in FER, onaverage in the same direction which represents that ER has positive effect on theFER and this relationship is statistically significant.  62.1526 percentof the variation in FER is explained by ER. The outcomes of Breusch-Godfrey test (LM test, ARCHtest, and the Normality test are that there is a serial correlation among residuals, the variance of residuals is notconstant, and the residuals are not normally distributed.

  17. Naval Reserve Annual Operating Costs

    Science.gov (United States)

    1975-10-29

    C. c ) CPi i 0 0 00 0 le C C.C~r In 1]1 In 00 It .- I to C-38 ’U2 WIX ’W~ - m u. -C-LC m4 C v , v ul FA ?w % -D 1 o r cl jc j, II t %c oK W)i Ir of... platform programs, while Program 11 contains 26 sub-programs each having a separate Reserve program sponsor. The distribution of Program 11 resources is...a mix of specific skills required to bring an active Navy oper-Iating platform to organizational manning. Each SRU is tailored to a specific ship

  18. Oribatid mites from the Vohimana Reserve, Madagascar (Acari: Oribatida, II

    Directory of Open Access Journals (Sweden)

    Mahunka, S.

    2009-11-01

    Full Text Available Further studies on the oribatid species collected from the Vohimana Reserve (Madagascar are presented. Altogether 13 species are listed, of them two represent new genera (Rugocepheus gen. nov. and Madabelba gen. nov., furthermore seven species are new to science. The other six species were earlier mentioned from different regions of the island, they are however little known.

  19. A Century in Reserve and Beyond

    National Research Council Canada - National Science Library

    Monagle, James P

    2008-01-01

    ... Reserve, this Strategy Research Project (SRP) describes the role of the Army Reserve from its beginning as a reserve corps of medical doctors to that of a strategic reserve force, and then to its current operational role...

  20. Science and data science.

    Science.gov (United States)

    Blei, David M; Smyth, Padhraic

    2017-08-07

    Data science has attracted a lot of attention, promising to turn vast amounts of data into useful predictions and insights. In this article, we ask why scientists should care about data science. To answer, we discuss data science from three perspectives: statistical, computational, and human. Although each of the three is a critical component of data science, we argue that the effective combination of all three components is the essence of what data science is about.

  1. Science in Science Fiction.

    Science.gov (United States)

    Allday, Jonathan

    2003-01-01

    Offers some suggestions as to how science fiction, especially television science fiction programs such as "Star Trek" and "Star Wars", can be drawn into physics lessons to illuminate some interesting issues. (Author/KHR)

  2. Biological science in conservation

    Science.gov (United States)

    David M. Johns

    2000-01-01

    Large-scale wildlands reserve systems offer one of the best hopes for slowing, if not reversing, the loss of biodiversity and wilderness. Establishing such reserves requires both sound biology and effective advocacy. Attempts by The Wildlands Project and its cooperators to meld science and advocacy in the service of conservation is working, but is not without some...

  3. 24 CFR 891.605 - Replacement reserve.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserve. 891.605... 8 Assistance § 891.605 Replacement reserve. (a) Establishment of reserve. The Borrower shall establish and maintain a replacement reserve to aid in funding extraordinary maintenance, and repair and...

  4. 24 CFR 891.405 - Replacement reserve.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserve. 891.405....405 Replacement reserve. (a) Establishment of reserve. The Owner shall establish and maintain a replacement reserve to aid in funding extraordinary maintenance and repair and replacement of capital items...

  5. Aksu-Zhabagly Nature Reserve's 90-anniversary

    Directory of Open Access Journals (Sweden)

    Anatoliy F. Kovshar

    2016-05-01

    whistling thrush (Myophonus caeruleus turcestanicus, paradise flycatcher (Terpsiphone paradisi leucogaster and several species of highland finches, including Eurasian crimson-winged finch (Rhodopechys sanguinea, white-winged snowfinch (Montifringilla nivalis alpicola and Brandt's mountain finch (Leucosticte brandti; reptiles – Ophisaurus apodus, Elape dione and Coluber rhodorhachis. 18 Vertebrate and 26 invertebrate species are listed in the Red Data Book of Kazakhstan. In the 90 years of its existence a huge research was carried out and the scientific staff of field biologists, botanists and zoologists were prepared (N.K. Karmysheva, V.V. Shevchenko, F.D. Shaposhnikov, V.D. Utekhin, A.F. Kovshar, A.A. Ivaschenko, B.M. Gubin, Yu.A. Grachyov, etc.. At the same time dozens of expeditions were working on this territory from several scientific institutions – institutes of botany and zoology (Alma-Ata, Tashkent, Leningrad, Kiev, botanical gardens (Moscow, Tashkent, Alma-Ata, All-Union Institute of Medicinal and Aromatic Plants (Moscow, All-Union Institute of Pharmacology (Moscow, Institute of Plant Protection (Alma-Ata, Zoological Museum of Moscow State University (Moscow, Palaeontological Institute of the Academy of Sciences of USSR and many others. As a result from the material collected on the territory of the nature reserve, more than 900 scientific works were published, including 11 issues of Proceedings of the nature reserve, published since 1948 till 2016.

  6. Calculation program development for spinning reserve

    International Nuclear Information System (INIS)

    1979-01-01

    This study is about optimal holding of spinning reserve and optimal operation for it. It deals with the purpose and contents of the study, introduction of the spinning reserve electricity, speciality of the spinning reserve power, the result of calculation, analysis for limited method of optimum load, calculation of requirement for spinning reserve, analysis on measurement of system stability with summary, purpose of the analysis, cause of impact of the accident, basics on measurement of spinning reserve and conclusion. It has the reference on explanation for design of spinning reserve power program and using and trend about spinning reserve power in Korea.

  7. Information Science: Science or Social Science?

    OpenAIRE

    Sreeramana Aithal; Paul P.K.,; Bhuimali A.

    2017-01-01

    Collection, selection, processing, management, and dissemination of information are the main and ultimate role of Information Science and similar studies such as Information Studies, Information Management, Library Science, and Communication Science and so on. However, Information Science deals with some different characteristics than these subjects. Information Science is most interdisciplinary Science combines with so many knowledge clusters and domains. Information Science is a broad disci...

  8. Introducing optional reserve ratios in Hungary

    OpenAIRE

    Lóránt Varga

    2010-01-01

    As of the reserve maintenance period commencing in November 2010, Hungarian credit institutions will be free to decide whether to apply the previously valid 2% reserve ratio, or to apply a higher mandatory reserve ratio. Credit institutions required to hold reserves may select from reserve ratios of 2, 3, 4 and 5%, and may change their decision on a semi-annual basis. In line with the international best practice, the purpose of the MNB’s reserve requirement system is to support credit institu...

  9. Reservation wages, expected wages and unemployment

    OpenAIRE

    Brown, S; Taylor, K

    2013-01-01

    We model unemployment duration, reservation and expected wages simultaneously for individuals not in work, where wage expectations are identified via an exogenous policy shock. The policy shock increased expected wages, which were found to be positively associated with reservation wages.

  10. Transforming the Reserve Component: Four Essays

    National Research Council Canada - National Science Library

    Binnendijk, Hans; Baranick, Michael J; Bell, Raymond E., Jr; Cordero, Gina; Duncan, Stephen M; Holshek, Christopher; Wentz, Larry

    2005-01-01

    This volume contains four essays on various aspects of the Reserve Component. We publish it at a time when Reserves are serving overseas at historically high rates and when new missions like homeland security demand their attention...

  11. 47 CFR 25.219 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false [Reserved] 25.219 Section 25.219 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Technical Standards § 25.219 [Reserved] ...

  12. 47 CFR 25.402 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false [Reserved] 25.402 Section 25.402 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Competitive Bidding Procedures for DARS § 25.402 [Reserved] ...

  13. Reservation system with graphical user interface

    KAUST Repository

    Mohamed, Mahmoud A. Abdelhamid; Jamjoom, Hani T.; Podlaseck, Mark E.; Qu, Huiming; Shae, Zon-Yin; Sheopuri, Anshul

    2012-01-01

    Techniques for providing a reservation system are provided. The techniques include displaying a scalable visualization object, wherein the scalable visualization object comprises an expanded view element of the reservation system depicting

  14. 47 CFR 80.146 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... MARITIME SERVICES Operating Requirements and Procedures Shipboard General Purpose Watches § 80.146 [Reserved] ... 47 Telecommunication 5 2010-10-01 2010-10-01 false [Reserved] 80.146 Section 80.146...

  15. 47 CFR 80.145 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... MARITIME SERVICES Operating Requirements and Procedures Special Procedures-Ship Stations § 80.145 [Reserved] Shipboard General Purpose Watches ... 47 Telecommunication 5 2010-10-01 2010-10-01 false [Reserved] 80.145 Section 80.145...

  16. 5 CFR 330.610 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false [Reserved] 330.610 Section 330.610 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RECRUITMENT, SELECTION, AND... Employees § 330.610 [Reserved] ...

  17. 5 CFR 330.603 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false [Reserved] 330.603 Section 330.603 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RECRUITMENT, SELECTION, AND... Employees § 330.603 [Reserved] ...

  18. 40 CFR 405.73 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 405.73 Section 405.73 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS DAIRY... § 405.73 [Reserved] ...

  19. 40 CFR 408.73 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 408.73 Section 408.73 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS... Processing Subcategory § 408.73 [Reserved] ...

  20. 40 CFR 407.73 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 407.73 Section 407.73 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS... Vegetables Subcategory § 407.73 [Reserved] ...

  1. A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions

    Science.gov (United States)

    Shimizu, Kiminori; Paul, Sanjoy; Ohba, Ayumi; Gonoi, Tohru; Watanabe, Akira; Gomi, Katsuya

    2017-01-01

    Successful treatment of aspergillosis caused by Aspergillus fumigatus is threatened by an increasing incidence of drug resistance. This situation is further complicated by the finding that strains resistant to azoles, the major antifungal drugs for aspergillosis, have been widely disseminated across the globe. To elucidate mechanisms underlying azole resistance, we identified a novel transcription factor that is required for normal azole resistance in Aspergillus fungi including A. fumigatus, Aspergillus oryzae, and Aspergillus nidulans. This fungal-specific Zn2-Cys6 type transcription factor AtrR was found to regulate expression of the genes related to ergosterol biosynthesis, including cyp51A that encodes a target protein of azoles. The atrR deletion mutant showed impaired growth under hypoxic conditions and attenuation of virulence in murine infection model for aspergillosis. These results were similar to the phenotypes for a mutant strain lacking SrbA that is also a direct regulator for the cyp51A gene. Notably, AtrR was responsible for the expression of cdr1B that encodes an ABC transporter related to azole resistance, whereas SrbA was not involved in the regulation. Chromatin immunoprecipitation assays indicated that AtrR directly bound both the cyp51A and cdr1B promoters. In the clinically isolated itraconazole resistant strain that harbors a mutant Cyp51A (G54E), deletion of the atrR gene resulted in a hypersensitivity to the azole drugs. Together, our results revealed that AtrR plays a pivotal role in a novel azole resistance mechanism by co-regulating the drug target (Cyp51A) and putative drug efflux pump (Cdr1B). PMID:28052140

  2. Science Smiles

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Science Smiles. Articles in Resonance – Journal of Science Education. Volume 1 Issue 4 April 1996 pp 4-4 Science Smiles. Chief Editor's column / Science Smiles · R K Laxman · More Details Fulltext PDF. Volume 1 Issue 5 May 1996 pp 3-3 Science Smiles.

  3. Reserve evaluation of minerals at NUCLEBRAS

    International Nuclear Information System (INIS)

    Marques, J.P.M.; Guerra, P.A.G.; Vinha, C.A.G. da

    1980-10-01

    The method used for the reserve evaluation of minerals, particularly of uranium, as used worldwide, and specially at NUCLEBRAS is described. This is done through a series of procedures envolving basic definitions, reserve evaluation methods (conventional, statistical and geoestatistical), data management, use of computer systems, classification and evaluation of reserves. (Author) [pt

  4. 24 CFR 880.602 - Replacement reserve.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserve. 880.602... Replacement reserve. (a) A replacement reserve must be established and maintained in an interest-bearing account to aid in funding extraordinary maintenance and repair and replacement of capital items. (1) Part...

  5. 24 CFR 891.745 - Replacement reserve.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserve. 891.745... and Individuals-Section 162 Assistance § 891.745 Replacement reserve. The general requirements for the replacement reserve are provided in § 891.605. For projects funded under §§ 891.655 through 891.790, the...

  6. Poverty and corruption compromise tropical forest reserves.

    Science.gov (United States)

    Wright, S Joseph; Sanchez-Azofeifa, G Arturo; Portillo-Quintero, Carlos; Davies, Diane

    2007-07-01

    We used the global fire detection record provided by the satellite-based Moderate Resolution Imaging Spectroradiometer (MODIS) to determine the number of fires detected inside 823 tropical and subtropical moist forest reserves and for contiguous buffer areas 5, 10, and 15 km wide. The ratio of fire detection densities (detections per square kilometer) inside reserves to their contiguous buffer areas provided an index of reserve effectiveness. Fire detection density was significantly lower inside reserves than in paired, contiguous buffer areas but varied by five orders of magnitude among reserves. The buffer: reserve detection ratio varied by up to four orders of magnitude among reserves within a single country, and median values varied by three orders of magnitude among countries. Reserves tended to be least effective at reducing fire frequency in many poorer countries and in countries beset by corruption. Countries with the most successful reserves include Costa Rica, Jamaica, Malaysia, and Taiwan and the Indonesian island of Java. Countries with the most problematic reserves include Cambodia, Guatemala, Paraguay, and Sierra Leone and the Indonesian portion of Borneo. We provide fire detection density for 3964 tropical and subtropical reserves and their buffer areas in the hope that these data will expedite further analyses that might lead to improved management of tropical reserves.

  7. Assessment of secondary aluminum reserves of nations

    DEFF Research Database (Denmark)

    Maung, Kyaw Nyunt; Yoshida, Tomoharu; Liu, Gang

    2017-01-01

    aluminum resources are accumulated in landfill sites. Understanding the sizes of primary and secondary aluminum reserves enables us to extend knowledge of efficient raw material sourcing from a narrow perspective of primary reserves alone to a broader perspective of both primary and secondary reserves...

  8. 24 CFR 572.125 - Replacement reserves.

    Science.gov (United States)

    2010-04-01

    ...) Homeownership Program Requirements-Implementation Grants § 572.125 Replacement reserves. (a) Purpose. A single replacement reserve may be established for the homeownership program only if HUD determines it is necessary to... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Replacement reserves. 572.125...

  9. Micro-level stochastic loss reserving

    NARCIS (Netherlands)

    Antonio, K.; Plat, R.

    2010-01-01

    To meet future liabilities general insurance companies will set-up reserves. Predicting future cash-flows is essential in this process. Actuarial loss reserving methods will help them to do this in a sound way. The last decennium a vast literature about stochastic loss reserving for the general

  10. Evaluation system of minerals reserve at Nuclebras

    International Nuclear Information System (INIS)

    Marques, J.P.M.; Guerra, P.A.G.; Vinha, C.A.G. da.

    1980-01-01

    The paper describes the methodology used for the reserve evaluation of minerals, particularly of uranium, as used world wide, and specially at Nuclebras. The paper discusses a series of procedures envolving basic definitions, reserve evaluation methods (Conventional, Statistical and Geoestatistical), data management, use of computer systems, classification of reserves as well as the results achieved [pt

  11. Reserve Requirements and Monetary Management; An Introduction

    OpenAIRE

    International Monetary Fund

    1993-01-01

    Reserve requirements are widely used by central banks as a means to improve monetary control, an instrument for policy implementation, a source of revenue, and a safeguard of bank liquidity. The effectiveness of reserve requirements in fulfilling these functions is reviewed, and the detailed modalities of their use are examined. Reserve requirements in a sample of developing countries are described.

  12. 42 CFR 417.934 - Reserve requirement.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Reserve requirement. 417.934 Section 417.934 Public... PLANS Administration of Outstanding Loans and Loan Guarantees § 417.934 Reserve requirement. (a) Timing... section 1305 of the PHS Act was required to establish a restricted reserve account on the earlier of the...

  13. Science or Science Fiction?

    DEFF Research Database (Denmark)

    Lefsrud, Lianne M.; Meyer, Renate

    2012-01-01

    This paper examines the framings and identity work associated with professionals’ discursive construction of climate change science, their legitimation of themselves as experts on ‘the truth’, and their attitudes towards regulatory measures. Drawing from survey responses of 1077 professional......, legitimation strategies, and use of emotionality and metaphor. By linking notions of the science or science fiction of climate change to the assessment of the adequacy of global and local policies and of potential organizational responses, we contribute to the understanding of ‘defensive institutional work...

  14. Reserve selection with land market feedbacks.

    Science.gov (United States)

    Butsic, Van; Lewis, David J; Radeloff, Volker C

    2013-01-15

    How to best site reserves is a leading question for conservation biologists. Recently, reserve selection has emphasized efficient conservation: maximizing conservation goals given the reality of limited conservation budgets, and this work indicates that land market can potentially undermine the conservation benefits of reserves by increasing property values and development probabilities near reserves. Here we propose a reserve selection methodology which optimizes conservation given both a budget constraint and land market feedbacks by using a combination of econometric models along with stochastic dynamic programming. We show that amenity based feedbacks can be accounted for in optimal reserve selection by choosing property price and land development models which exogenously estimate the effects of reserve establishment. In our empirical example, we use previously estimated models of land development and property prices to select parcels to maximize coarse woody debris along 16 lakes in Vilas County, WI, USA. Using each lake as an independent experiment, we find that including land market feedbacks in the reserve selection algorithm has only small effects on conservation efficacy. Likewise, we find that in our setting heuristic (minloss and maxgain) algorithms perform nearly as well as the optimal selection strategy. We emphasize that land market feedbacks can be included in optimal reserve selection; the extent to which this improves reserve placement will likely vary across landscapes. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. Naval Petroleum and Oil Shale Reserves

    International Nuclear Information System (INIS)

    1992-01-01

    During fiscal year 1992, the reserves generated $473 million in revenues, a $181 million decrease from the fiscal year 1991 revenues, primarily due to significant decreases in oil and natural gas prices. Total costs were $200 million, resulting in net cash flow of $273 million, compared with $454 million in fiscal year 1991. From 1976 through fiscal year 1992, the Naval Petroleum and Oil Shale Reserves generated more than $15 billion in revenues and a net operating income after costs of $12.5 billion. In fiscal year 1992, production at the Naval Petroleum Reserves at maximum efficient rates yielded 26 million barrels of crude oil, 119 billion cubic feet of natural gas, and 164 million gallons of natural gas liquids. From April to November 1992, senior managers from the Naval Petroleum and Oil Shale Reserves held a series of three workshops in Boulder, Colorado, in order to build a comprehensive Strategic Plan as required by Secretary of Energy Notice 25A-91. Other highlights are presented for the following: Naval Petroleum Reserve No. 1--production achievements, crude oil shipments to the strategic petroleum reserve, horizontal drilling, shallow oil zone gas injection project, environment and safety, and vanpool program; Naval Petroleum Reserve No. 2--new management and operating contractor and exploration drilling; Naval Petroleum Reserve No. 3--steamflood; Naval Oil Shale Reserves--protection program; and Tiger Team environmental assessment of the Naval Petroleum and Oil Shale Reserves in Colorado, Utah, and Wyoming

  16. A General Business Model for Marine Reserves

    Science.gov (United States)

    Sala, Enric; Costello, Christopher; Dougherty, Dawn; Heal, Geoffrey; Kelleher, Kieran; Murray, Jason H.; Rosenberg, Andrew A.; Sumaila, Rashid

    2013-01-01

    Marine reserves are an effective tool for protecting biodiversity locally, with potential economic benefits including enhancement of local fisheries, increased tourism, and maintenance of ecosystem services. However, fishing communities often fear short-term income losses associated with closures, and thus may oppose marine reserves. Here we review empirical data and develop bioeconomic models to show that the value of marine reserves (enhanced adjacent fishing + tourism) may often exceed the pre-reserve value, and that economic benefits can offset the costs in as little as five years. These results suggest the need for a new business model for creating and managing reserves, which could pay for themselves and turn a profit for stakeholder groups. Our model could be expanded to include ecosystem services and other benefits, and it provides a general framework to estimate costs and benefits of reserves and to develop such business models. PMID:23573192

  17. Substantiating the Incurred but not Reported Reserve

    Directory of Open Access Journals (Sweden)

    Georgeta Vintilã

    2009-12-01

    Full Text Available In order to handle past and future liability taken by insurance contracts concluded, any insurance company must constitute and maintain technical reserves. Substantiating technical reserves is done through actuarial methods and its over-evaluation or under-evaluation influence solvency and financial performance of the insurance companies, in the sense of reducing solvency through over-evaluating reserves and, respectively, influencing profit (hence of outstanding tax through under-evaluating reserves. An important reserve for insurance companies is represented by the incurred but not reported reserve, as it allows the estimation of the liability the company may confront in the future, generated by events occurred in the past, which are not currently known in the present but will be reported in the future.

  18. Drawbacks in the scientification of forensic science.

    Science.gov (United States)

    Biedermann, A; Curran, J

    2014-12-01

    This letter to the Editor comments on the article On the limitations of probability in conceptualizing pattern matches in forensic science by P. T. Jayaprakash (Forensic Science International, [10]). Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  19. Reserve valuation in electric power systems

    Science.gov (United States)

    Ruiz, Pablo Ariel

    Operational reliability is provided in part by scheduling capacity in excess of the load forecast. This reserve capacity balances the uncertain power demand with the supply in real time and provides for equipment outages. Traditionally, reserve scheduling has been ensured by enforcing reserve requirements in the operations planning. An alternate approach is to employ a stochastic formulation, which allows the explicit modeling of the sources of uncertainty. This thesis compares stochastic and reserve methods and evaluates the benefits of a combined approach for the efficient management of uncertainty in the unit commitment problem. Numerical studies show that the unit commitment solutions obtained for the combined approach are robust and superior with respect to the traditional approach. These robust solutions are especially valuable in areas with a high proportion of wind power, as their built-in flexibility allows the dispatch of practically all the available wind power while minimizing the costs of operation. The scheduled reserve has an economic value since it reduces the outage costs. In several electricity markets, reserve demand functions have been implemented to take into account the value of reserve in the market clearing process. These often take the form of a step-down function at the reserve requirement level, and as such they may not appropriately represent the reserve value. The value of reserve is impacted by the reliability, dynamic and stochastic characteristics of system components, the system operation policies, and the economic aspects such as the risk preferences of the demand. In this thesis, these aspects are taken into account to approximate the reserve value and construct reserve demand functions. Illustrative examples show that the demand functions constructed have similarities with those implemented in some markets.

  20. The energy reserves of our planet

    International Nuclear Information System (INIS)

    Bischoff, G.

    1977-01-01

    Starting from a prognosis for the development of the world energy consumption, the situation of special primary energy sources (reserves, potential) is briefly described. According to the amount and location of the reserves - 90% of the fossil energy reserves are in industrialized countries -, coal will play a leading role in meeting the energy demands of the future. Without breeder reactors, the role of nuclear energy will be limited in time. (UA) [de

  1. Reserve reporting from a banker's perspective

    International Nuclear Information System (INIS)

    Larson, B.O.

    1996-01-01

    A banker's perspective of oil and gas reserve reporting was presented. Topics chosen for discussion emphasized oil and gas lending, and the type of capital which is most relevant to the oil and gas industry. The concept of capital differentiation, potential worst case, and least specialization, were explained. An explanation of the reasons for the lender's different perspective on reserves was given. Methods that banks use to limit risk, and the role that reserve reports play in loan approvals were also reviewed

  2. IGT calculates world reserves of fossil fuels

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    The Institute of Gas Technology has published the IGT World Reserves Survey, giving their latest tabulation of world reserves of fossil fuels and uranium. The report contains 120 Tables and 41 Figures. Estimates are provided for proved reserves, resources, current production, and life indexes of the non-renewable energy sources of the US and of the world as a whole. World regional data are also provided in many cases. The data are summarized here. 2 figures, 5 tables

  3. Reserve requirement systems in OECD countries

    OpenAIRE

    Yueh-Yun C. O’Brien

    2007-01-01

    This paper compares the reserve requirements of OECD countries. Reserve requirements are the minimum percentages or amounts of liabilities that depository institutions are required to keep in cash or as deposits with their central banks. To facilitate monetary policy implementation, twenty-four of the thirty OECD countries impose reserve requirements to influence their banking systems’ demand for liquidity. These include twelve OECD countries that are also members of the European Economic and...

  4. When will fossil fuel reserves be diminished?

    International Nuclear Information System (INIS)

    Shafiee, Shahriar; Topal, Erkan

    2009-01-01

    Crude oil, coal and gas are the main resources for world energy supply. The size of fossil fuel reserves and the dilemma that 'when non-renewable energy will be diminished' is a fundamental and doubtful question that needs to be answered. This paper presents a new formula for calculating when fossil fuel reserves are likely to be depleted and develops an econometrics model to demonstrate the relationship between fossil fuel reserves and some main variables. The new formula is modified from the Klass model and thus assumes a continuous compound rate and computes fossil fuel reserve depletion times for oil, coal and gas of approximately 35, 107 and 37 years, respectively. This means that coal reserves are available up to 2112, and will be the only fossil fuel remaining after 2042. In the Econometrics model, the main exogenous variables affecting oil, coal and gas reserve trends are their consumption and respective prices between 1980 and 2006. The models for oil and gas reserves unexpectedly show a positive and significant relationship with consumption, while presenting a negative and significant relationship with price. The econometrics model for coal reserves, however, expectedly illustrates a negative and significant relationship with consumption and a positive and significant relationship with price. Consequently, huge reserves of coal and low-level coal prices in comparison to oil and gas make coal one of the main energy substitutions for oil and gas in the future, under the assumption of coal as a clean energy source

  5. Reservation system with graphical user interface

    KAUST Repository

    Mohamed, Mahmoud A. Abdelhamid

    2012-01-05

    Techniques for providing a reservation system are provided. The techniques include displaying a scalable visualization object, wherein the scalable visualization object comprises an expanded view element of the reservation system depicting information in connection with a selected interval of time and a compressed view element of the reservation system depicting information in connection with one or more additional intervals of time, maintaining a visual context between the expanded view and the compressed view within the visualization object, and enabling a user to switch between the expanded view and the compressed view to facilitate use of the reservation system.

  6. The Physics Entrepreneurship Program at Case Western Reserve University

    Science.gov (United States)

    Taylor, Cyrus

    2001-10-01

    The Physics Entrepreneurship Program is a new, two-year Master's Program designed to empower physicists as entrepreneurs. Launched by the Dept. of Physics at Case Western Reserve University in close cooperation with the Weatherhead School of Management, the program is now in its second year. This innovative new program has already attracted important attention from the business community, including seed funding of a student launched venture, international press coverage, including an article in Business Week, and government interest, including an invitation to brief the Advisory Board of the Mathematical and Physical Sciences Division of the National Science Foundation. This talk will discuss the structure and content of the program, the lessons we are learning, and early indicators of success including a student-launched new business venture that has already secured more than $ 250,000 in seed funding.

  7. 10 years anniversary of the Poles'e state radioecological reserve (collected articles)

    International Nuclear Information System (INIS)

    Parfenov, V.I.

    1998-01-01

    The results of long time investigations of radionuclide contamination dynamics of soils, flora and fauna conducted by research workers of the reserve and National Academy of Sciences of Belarus on the territory of the reserve are offered. The different aspects of plant growth and animal behaviour in new ecological conditions are estimated

  8. 77 FR 16211 - Availability of Seats for the Northwestern Hawaiian Islands Coral Reef Ecosystem Reserve Advisory...

    Science.gov (United States)

    2012-03-20

    ... Monument World Heritage site established by UNESCO in July, 2010. The Reserve encompasses an area of the... nautical miles long and 100 nautical miles wide. The Reserve is managed by the Secretary of Commerce... Service, National Science Foundation, U.S. Coast Guard, Western Pacific Regional Fishery Management...

  9. 76 FR 77779 - Availability of Seats for the Northwestern Hawaiian Islands Coral Reef Ecosystem Reserve Advisory...

    Science.gov (United States)

    2011-12-14

    ... Papahanaumokuakea Marine National Monument World Heritage site established by UNESCO in July, 2010. The Reserve... approximately 1200 nautical miles long and 100 nautical miles wide. The Reserve is managed by the Secretary of... National Marine Fisheries Service, National Science Foundation, U.S. Coast Guard, Western Pacific Regional...

  10. 7 CFR 1221.114 - Operating reserve.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... INFORMATION ORDER Sorghum Promotion, Research, and Information Order Sorghum Promotion, Research, and Information Board § 1221.114 Operating reserve. The Board may establish an operating monetary reserve and may...

  11. 24 CFR 891.855 - Replacement reserves.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Replacement reserves. 891.855... § 891.855 Replacement reserves. (a) The mixed-finance owner shall establish and maintain a replacement... the funds will be used to pay for capital replacement costs for the Section 202 or 811 supportive...

  12. 40 CFR 406.43 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 406.43 Section 406.43 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GRAIN MILLS POINT SOURCE CATEGORY Bulgur Wheat Flour Milling Subcategory § 406.43 [Reserved] ...

  13. 40 CFR 406.23 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 406.23 Section 406.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GRAIN MILLS POINT SOURCE CATEGORY Corn Dry Milling Subcategory § 406.23 [Reserved] ...

  14. 40 CFR 406.13 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 406.13 Section 406.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GRAIN MILLS POINT SOURCE CATEGORY Corn Wet Milling Subcategory § 406.13 [Reserved] ...

  15. 41 CFR 101-39.205 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.2-GSA Interagency Fleet Management System Services § 101-39.205 [Reserved] ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true [Reserved] 101-39.205...

  16. 22 CFR 99.3 - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false [Reserved] 99.3 Section 99.3 Foreign Relations DEPARTMENT OF STATE LEGAL AND RELATED SERVICES REPORTING ON CONVENTION AND NON-CONVENTION ADOPTIONS OF EMIGRATING CHILDREN § 99.3 [Reserved] ...

  17. 14 CFR 99.12 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false [Reserved] 99.12 Section 99.12 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES SECURITY CONTROL OF AIR TRAFFIC General § 99.12 [Reserved] ...

  18. 26 CFR 1.46-10 - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true [Reserved] 1.46-10 Section 1.46-10 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Rules for Computing Credit for Investment in Certain Depreciable Property § 1.46-10 [Reserved] ...

  19. 26 CFR 48.4161(b) - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 16 2010-04-01 2010-04-01 true [Reserved] 48.4161(b) Section 48.4161(b) Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) MISCELLANEOUS EXCISE TAXES MANUFACTURERS AND RETAILERS EXCISE TAXES Sporting Goods § 48.4161(b) [Reserved] ...

  20. 26 CFR 48.4161(a) - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 16 2010-04-01 2010-04-01 true [Reserved] 48.4161(a) Section 48.4161(a) Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) MISCELLANEOUS EXCISE TAXES MANUFACTURERS AND RETAILERS EXCISE TAXES Sporting Goods § 48.4161(a) [Reserved] ...

  1. 20 CFR 410.394 - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false [Reserved] 410.394 Section 410.394 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship and Dependency § 410.394 [Reserved] ...

  2. 7 CFR 1900.57 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false [Reserved] 1900.57 Section 1900.57 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... GENERAL Adverse Decisions and Administrative Appeals § 1900.57 [Reserved] ...

  3. 39 CFR 111.5 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false [Reserved] 111.5 Section 111.5 Postal Service UNITED STATES POSTAL SERVICE POST OFFICE SERVICES [DOMESTIC MAIL] GENERAL INFORMATION ON POSTAL SERVICE § 111.5 [Reserved] ...

  4. 29 CFR 579.4 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false [Reserved] 579.4 Section 579.4 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS CHILD LABOR VIOLATIONS-CIVIL MONEY PENALTIES § 579.4 [Reserved] ...

  5. 19 CFR 210.22 - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false [Reserved] 210.22 Section 210.22 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Motions § 210.22 [Reserved] ...

  6. 12 CFR 614.4710 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false [Reserved] 614.4710 Section 614.4710 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM LOAN POLICIES AND OPERATIONS Banks for Cooperatives and Agricultural Credit Banks Financing International Trade § 614.4710 [Reserved] ...

  7. 12 CFR 996.1 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false [Reserved] 996.1 Section 996.1 Banks and Banking FEDERAL HOUSING FINANCE BOARD NON-BANK SYSTEM ENTITIES AUTHORITY FOR BANK ASSISTANCE OF THE RESOLUTION FUNDING CORPORATION § 996.1 [Reserved] ...

  8. 29 CFR 4.106 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true [Reserved] 4.106 Section 4.106 Labor Office of the Secretary of Labor LABOR STANDARDS FOR FEDERAL SERVICE CONTRACTS Application of the McNamara-O'Hara Service Contract Act Introductory § 4.106 [Reserved] Agencies Whose Contracts May Be Covered ...

  9. 46 CFR 308.301 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false [Reserved] 308.301 Section 308.301 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE Second Seamen's War Risk Insurance § 308.301 [Reserved] ...

  10. 46 CFR 308.305 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false [Reserved] 308.305 Section 308.305 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE Second Seamen's War Risk Insurance § 308.305 [Reserved] ...

  11. 7 CFR 1709.2 Policy. - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false [Reserved] 1709.2 Policy. Section 1709.2 Policy. Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ASSISTANCE TO HIGH ENERGY COST COMMUNITIES General Requirements § 1709.2 Policy. [Reserved] ...

  12. 7 CFR 1709.202 Policy. - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false [Reserved] 1709.202 Policy. Section 1709.202 Policy... AGRICULTURE ASSISTANCE TO HIGH ENERGY COST COMMUNITIES Bulk Fuel Revolving Fund Grant Program § 1709.202 Policy. [Reserved] ...

  13. 15 CFR 2003.3 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false [Reserved] 2003.3 Section 2003.3 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE REGULATIONS OF TRADE POLICY STAFF COMMITTEE § 2003.3 [Reserved] ...

  14. Price, technology, and ore reserves, ch. 2

    International Nuclear Information System (INIS)

    McAllister, A.L.

    1976-01-01

    Factors determining ore reserves in view of future uses are investigated: existing mining technologies, new techniques, price-technology relationship, effects of the use of different energy sources, exploration techniques, and price change are discussed. The effect of price and technology on reserves of specific commodities is dealth with. A section is also devoted to uranium

  15. 21 CFR 211.170 - Reserve samples.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Reserve samples. 211.170 Section 211.170 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL... of deterioration unless visual examination would affect the integrity of the reserve sample. Any...

  16. 48 CFR 4.501 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false [Reserved] 4.501 Section 4.501 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Electronic Commerce in Contracting 4.501 [Reserved] ...

  17. 5 CFR 9901.513 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false [Reserved] 9901.513 Section 9901.513 Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT... (NSPS) Staffing and Employment External Recruitment and Internal Placement § 9901.513 [Reserved] ...

  18. 31 CFR 281.2 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false [Reserved] 281.2 Section 281.2 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FOREIGN EXCHANGE OPERATIONS § 281.2 [Reserved] ...

  19. 7 CFR 1776.4 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false [Reserved] 1776.4 Section 1776.4 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) HOUSEHOLD WATER WELL SYSTEM GRANT PROGRAM General § 1776.4 [Reserved] ...

  20. 49 CFR 17.4 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false [Reserved] 17.4 Section 17.4 Transportation Office of the Secretary of Transportation INTERGOVERNMENTAL REVIEW OF DEPARTMENT OF TRANSPORTATION PROGRAMS AND ACTIVITIES § 17.4 [Reserved] ...

  1. 7 CFR 1962.5 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true [Reserved] 1962.5 Section 1962.5 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... REGULATIONS (CONTINUED) PERSONAL PROPERTY Servicing and Liquidation of Chattel Security § 1962.5 [Reserved] ...

  2. 18 CFR 284.125 - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false [Reserved] 284.125 Section 284.125 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT... Certain Transportation by Intrastate Pipelines § 284.125 [Reserved] ...

  3. 40 CFR 73.32 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false [Reserved] 73.32 Section 73.32 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Allowance Tracking System § 73.32 [Reserved] ...

  4. 40 CFR 73.51 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false [Reserved] 73.51 Section 73.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Allowance Transfers § 73.51 [Reserved] ...

  5. 40 CFR 73.11 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false [Reserved] 73.11 Section 73.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Allowance Allocations § 73.11 [Reserved] ...

  6. 7 CFR 801.10 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false [Reserved] 801.10 Section 801.10 Agriculture Regulations of the Department of Agriculture (Continued) GRAIN INSPECTION, PACKERS AND STOCKYARD... FOR GRAIN INSPECTION EQUIPMENT § 801.10 [Reserved] ...

  7. 40 CFR 26.1124 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false [Reserved] 26.1124 Section 26.1124 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic Ethical...-nursing Adults § 26.1124 [Reserved] ...

  8. The Economics of NASA Mission Cost Reserves

    Science.gov (United States)

    Whitley, Sally; Shinn, Stephen

    2012-01-01

    Increases in NASA mission costs are well-noted but not well-understood, and there is little evidence that they are decreasing in frequency or amount over time. The need to control spending has led to analysis of the causes and magnitude of historical mission overruns, and many program control efforts are being implemented to attempt to prevent or mitigate the problem (NPR 7120). However, cost overruns have not abated, and while some direct causes of increased spending may be obvious (requirements creep, launch delays, directed changes, etc.), the underlying impetus to spend past the original budget may be more subtle. Gaining better insight into the causes of cost overruns will help NASA and its contracting organizations to avoid .them. This paper hypothesizes that one cause of NASA mission cost overruns is that the availability of reserves gives project team members an incentive to make decisions and behave in ways that increase costs. We theorize that the presence of reserves is a contributing factor to cost overruns because it causes organizations to use their funds less efficiently or to control spending less effectively. We draw a comparison to the insurance industry concept of moral hazard, the phenomenon that the presence of insurance causes insureds to have more frequent and higher insurance losses, and we attempt to apply actuarial techniques to quantifY the increase in the expected cost of a mission due to the availability of reserves. We create a theoretical model of reserve spending motivation by defining a variable ReserveSpending as a function of total reserves. This function has a positive slope; for every dollar of reserves available, there is a positive probability of spending it. Finally, the function should be concave down; the probability of spending each incremental dollar of reserves decreases progressively. We test the model against available NASA CADRe data by examining missions with reserve dollars initially available and testing whether

  9. Disclosure of oil and gas reserve information

    International Nuclear Information System (INIS)

    Emsile, B.H.

    1998-01-01

    The current regulations regarding disclosure of oil and gas reserve information in Canada are described. These regulations have been in place since the early 1980s and have generally worked well, but there are some issues that need to be updated. The Alberta Securities Commission Oil and Gas Securities Task Force was established to review the regulations and the major issues that need to be addressed. The issues under consideration are: (1) reserve definitions and price assumptions, (2) use of deterministic or probabilistic reserve calculation methods, (3) use of audits in reserve reporting, (4) abandonment costs, (5) calculation of barrels of oil equivalents, and (6) the calculation of various performance indicators such as finding and development costs and reserve replacement ratios

  10. Primary Science Interview: Science Sparks

    Science.gov (United States)

    Bianchi, Lynne

    2016-01-01

    In this "Primary Science" interview, Lynne Bianchi talks with Emma Vanstone about "Science Sparks," which is a website full of creative, fun, and exciting science activity ideas for children of primary-school age. "Science Sparks" started with the aim of inspiring more parents to do science at home with their…

  11. Communicating Science

    Science.gov (United States)

    Russell, Nicholas

    2009-10-01

    Introduction: what this book is about and why you might want to read it; Prologue: three orphans share a common paternity: professional science communication, popular journalism, and literary fiction are not as separate as they seem; Part I. Professional Science Communication: 1. Spreading the word: the endless struggle to publish professional science; 2. Walk like an Egyptian: the alien feeling of professional science writing; 3. The future's bright? Professional science communication in the age of the internet; 4. Counting the horse's teeth: professional standards in science's barter economy; 5. Separating the wheat from the chaff: peer review on trial; Part II. Science for the Public: What Science Do People Need and How Might They Get It?: 6. The Public Understanding of Science (PUS) movement and its problems; 7. Public engagement with science and technology (PEST): fine principle, difficult practice; 8. Citizen scientists? Democratic input into science policy; 9. Teaching and learning science in schools: implications for popular science communication; Part III. Popular Science Communication: The Press and Broadcasting: 10. What every scientist should know about mass media; 11. What every scientist should know about journalists; 12. The influence of new media; 13. How the media represents science; 14. How should science journalists behave?; Part IV. The Origins of Science in Cultural Context: Five Historic Dramas: 15. A terrible storm in Wittenberg: natural knowledge through sorcery and evil; 16. A terrible storm in the Mediterranean: controlling nature with white magic and religion; 17. Thieving magpies: the subtle art of false projecting; 18. Foolish virtuosi: natural philosophy emerges as a distinct discipline but many cannot take it seriously; 19. Is scientific knowledge 'true' or should it just be 'truthfully' deployed?; Part V. Science in Literature: 20. Science and the Gothic: the three big nineteenth-century monster stories; 21. Science fiction: serious

  12. Social Media, Open Science, and Data Science Are Inextricably Linked.

    Science.gov (United States)

    Voytek, Bradley

    2017-12-20

    Should scientists use social media? Why practice open science? What is data science? Ten years ago, these phrases hardly existed. Now they are ubiquitous. Here I argue that these phenomena are inextricably linked and reflect similar underlying social and technological transformations. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. The Economics of NASA Mission Cost Reserves

    Science.gov (United States)

    Whitley, Sally; Shinn, Stephen

    2012-01-01

    Increases in NASA mission costs have led to analysis of the causes and magnitude of historical mission overruns as well as mitigation and prevention attempts. This paper hypothesizes that one cause is that the availability of reserves may reduce incentives to control costs. We draw a comparison to the insurance concept of moral hazard, and we use actuarial techniques to better understand the increase in mission costs due to the availability of reserves. NASA's CADRe database provided the data against which we tested our hypothesis and discovered that there is correlation between the amount of available reserves and project overruns, particularly for mission hardware cost increases. We address the question of how to prevent reserves from increasing mission spending without increasing cost risk to projects.

  14. Transforming the Reserve Component: Four Essays

    National Research Council Canada - National Science Library

    Binnendijk, Hans; Baranick, Michael J; Bell, Raymond E., Jr; Cordero, Gina; Duncan, Stephen M; Holshek, Christopher; Wentz, Larry

    2005-01-01

    .... The first essay calls for a fundamental restructuring of the Reserve Component in light of the largest mobilization since the Korean War, which has been fraught with problems in terms of combat...

  15. Phytosociological classification of the Nylsvley nature reserve

    CSIR Research Space (South Africa)

    Coetzee, BJ

    1977-12-01

    Full Text Available The vegetation of the Nylsvley Nature Reserve in the Transvaal Mixed Bushveld is classified hierarchically by the Braun-Blanquet method of vegetation survey. The vegetation is seasonal grassland and deciduous savanna with four floristically distinct...

  16. 24 CFR 266.110 - Reserve requirements.

    Science.gov (United States)

    2010-04-01

    ... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Housing Finance Agency Requirements § 266.110 Reserve requirements. (a) HFAs with top-tier designation or overall...

  17. 49 CFR 392.15 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS DRIVING OF COMMERCIAL MOTOR VEHICLES Driving of Commercial Motor Vehicles § 392.15 [Reserved] ...

  18. 49 CFR 392.18 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS DRIVING OF COMMERCIAL MOTOR VEHICLES Driving of Commercial Motor Vehicles § 392.18 [Reserved] ...

  19. 45 CFR 400.6 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Grants to States for Refugee Resettlement The State Plan § 400.6 [Reserved] ...

  20. 49 CFR 192.57 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Materials § 192.57 [Reserved] ...

  1. 49 CFR 192.61 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Materials § 192.61 [Reserved] ...

  2. Uniform Reserve Training and Retirement Category Administration

    National Research Council Canada - National Science Library

    Kohner, D

    1997-01-01

    This Instruction implement policy as provided in DoD Directive 1215.6, assigns responsibilities and prescribes procedures that pertain to the designation and use of uniform Reserve component (RC) categories (RCCs...

  3. U.S. Federal Reserve Systems

    Data.gov (United States)

    Department of Homeland Security — This dataset is comprised of forty-five entities that are part of the United States Federal Reserve System according to the United States Department of Treasury. The...

  4. 48 CFR 9904.405-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.405-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.405-10 [Reserved] ...

  5. 48 CFR 9904.402-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.402-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.402-10 [Reserved] ...

  6. 48 CFR 9904.409-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.409-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.409-10 [Reserved] ...

  7. 48 CFR 9904.408-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.408-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.408-10 [Reserved] ...

  8. 48 CFR 9904.401-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.401-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.401-10 [Reserved] ...

  9. 48 CFR 9904.403-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.403-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.403-10 [Reserved] ...

  10. 48 CFR 9904.406-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.406-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.406-10 [Reserved] ...

  11. 48 CFR 9904.404-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.404-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.404-10 [Reserved] ...

  12. 48 CFR 9904.400 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.400 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.400 [Reserved] ...

  13. 48 CFR 9904.410-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.410-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.410-10 [Reserved] ...

  14. 48 CFR 9904.407-10 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.407-10 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.407-10 [Reserved] ...

  15. 24 CFR 206.115 - [Reserved

    Science.gov (United States)

    2010-04-01

    ... MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES HOME EQUITY CONVERSION MORTGAGE INSURANCE Contract Rights and Obligations Mortgage Insurance Premiums § 206.115 [Reserved] ...

  16. Army Reserve Military Intelligence: Time for Change

    Science.gov (United States)

    2010-04-20

    Miramax Books, 2002. Goleman , Daniel . Emotional Intelligence . New York: Bantam Books, 1997. Goleman , Daniel , Richard Boyatzis, and Annie McKee...or position of the Department of the Army, Department of Defense, or the U.S. Government. ARMY RESERVE MILITARY INTELLIGENCE : TIME FOR CHANGE...Research Project 3. DATES COVERED 00-00-2009 to 00-00-2010 4. TITLE AND SUBTITLE Army Reserve Military Intelligence : Time for Change 5a

  17. Leadership Stability in Army Reserve Component Units

    Science.gov (United States)

    2013-01-01

    OMB control number. 1. REPORT DATE 2013 2. REPORT TYPE 3. DATES COVERED 00-00-2013 to 00-00-2013 4. TITLE AND SUBTITLE Leadership Stability in...standards for research quality and objectivity. Leadership Stability in Army Reserve Component Units Thomas F. Lippiatt, J. Michael Polich NATIONAL SECURITY...RESEARCH DIVISION Leadership Stability in Army Reserve Component Units Thomas F. Lippiatt, J. Michael Polich Prepared for the Office of the

  18. Exploration report in mining reserve XIV

    International Nuclear Information System (INIS)

    Spoturno Pioppo, J.; Lara Vigil, P.

    1991-01-01

    This report has been referred to the antecedents and works developed in the mining Reservation XIV. This Reservation, covered a 1900 km2 surface, involving the aerial photography Valentines Cerro Chato, Chileno, Rossel y Rius, Sarandi del Yi and Cuchilla del Pescado. It has been reduced this area to western part of the aerial phothograpy Pavas, releasing other areas such as Chileno, Rossel y Rius, Cuchilla del Pescado y Cerro Chato. Finally, gold, sulphures, pirite and carbonates iron oxides findings have been found.

  19. Unanswered Quibbles with Fractional Reserve Free Banking

    OpenAIRE

    Bagus, Philipp; Howden, David

    2011-01-01

    In this article we reply to George Selgin’s counterarguments to our article “Fractional Reserve Free Banking: Some Quibbles”. Selgin regards holding cash as saving while we focus on the real savings necessary to maintain investment projects. Real savings are unconsumed real income. Variations in real savings are not necessarily equal to variations in cash holdings. We show that a coordinated credit expansion in a fractional reserve free banking (FRFB) system is possible and that precautionary...

  20. Required reserves as a credit policy tool

    OpenAIRE

    Mimir, Yasin; Sunel, Enes; Taskin, Temel

    2012-01-01

    This paper conducts a quantitative investigation of the role of reserve requirements as a macroprudential policy tool. We build a monetary DSGE model with a banking sector in which (i) an agency problem between households and banks leads to endogenous capital constraints for banks in obtaining funds from households, (ii) banks are subject to time-varying reserve requirements that countercyclically respond to expected credit growth, (iii) households face cash-in-advance constraints, requiring ...

  1. Status of fossil fuel reserves; Etat des reserves des combustibles fossiles

    Energy Technology Data Exchange (ETDEWEB)

    Laherrere, J

    2005-07-01

    Reserves represent the sum of past and future productions up to the end of production. In most countries the reserve data of fields are confidential. Therefore, fossil fuel reserves are badly known because the published data are more political than technical and many countries make a confusion between resources and reserves. The cumulated production of fossil fuels represents only between a third and a fifth of the ultimate reserves. The production peak will take place between 2020 and 2050. In the ultimate reserves, which extrapolate the past, the fossil fuels represent three thirds of the overall energy. This document analyses the uncertainties linked with fossil fuel reserves: reliability of published data, modeling of future production, comparison with other energy sources, energy consumption forecasts, reserves/production ratio, exploitation of non-conventional hydrocarbons (tar sands, extra-heavy oils, bituminous shales, coal gas, gas shales, methane in overpressure aquifers, methane hydrates), technology impacts, prices impact, and reserves growth. (J.S.)

  2. Selling the SPR [Strategic Petroleum Reserve

    International Nuclear Information System (INIS)

    Gurney, J.

    1997-01-01

    The Strategic Petroleum Reserve (SPR) in the USA was created in 1975, in conjunction with the wider reserve programme of the International Energy Agency, following the 1973/74 Arab oil embargo. The only source of funding for the SPR has been annual appropriations bills from Congress. In 1994, however, Congress, seeking ways to balance the nation's budget and given the perception by many free market economists that the danger of serious oils supply disruption has passed, refused to allocate funds for SPR oil purchases. No crude oil stocks have been added to the reserve since then. In 1996, congress took the further step of requiring sales of oil from the reserve in order to pay for the programme's running costs and to meet the costs of maintaining the reserve's storage facilities. The reserve oil is stored in caverns under salt domes in the coastal regions of the Gulf of Mexico and some of these are beginning to fracture to the extent that they are having to be decommissioned. The SPR has been investigating ways of raising money in order to lessen its dependence on Congress. These include leasing pipelines and a marine terminal, and allowing the storage of foreign owned oil in underused caverns. (author)

  3. Environmental and developmental origins of ovarian reserve.

    Science.gov (United States)

    Richardson, M C; Guo, M; Fauser, B C J M; Macklon, N S

    2014-01-01

    BACKGROUND Oocyte number is established early in life before a gradual loss of this ovarian reserve during reproductive life until oocyte availability becomes limiting at the menopause. Although there is a large genetic component to the ovarian reserve achieved before birth, other influences including the maternal endocrine and nutritional milieu, and environmental factors may represent important developmental determinants. Environmental and nutritional factors may also modify the downward trajectory of ovarian reserve in adult life. The combination of these early and later life influences has the potential to lead to diminished ovarian reserve, compromising fertility in later reproductive years and altering age at natural menopause. METHODS Literature searches of the ISI Web of Knowledge database were carried out using the main terms 'ovarian reserve' and 'menopause AND age' in conjunction with a range of other terms encompassing a variety of factors with potential effects on ovarian reserve. The various searches were inspected manually and the relevant papers selected for critical analysis and interpretation. RESULTS Evidence was identified supporting the view that elevated prenatal androgens have an adverse effect on the early establishment of ovarian reserve, although the implications for ovarian reserve in the polycystic ovary syndrome (which may also be programmed through prenatal androgen exposure) remain uncertain. Recent evidence is cited suggesting that effects of maternal nutrient restriction on ovarian reserve may also involve changes in prenatal androgen exposure. A general rationale is developed through examination of evidence which emphasizes the roles of the aryl hydrocarbon receptor (AHR) and the estrogen receptor (ER) systems in ovarian reserve modulation. Because of their similarity to the natural ligands, many environmental compounds have the ability to bind to these receptors (albeit at lower affinities) and thereby have the potential to

  4. Evaluation Science

    Science.gov (United States)

    Patton, Michael Quinn

    2018-01-01

    Culturally and politically science is under attack. The core consequence of perceiving and asserting evaluation as science is that it enhances our credibility and effectiveness in supporting the importance of science in our world and brings us together with other scientists to make common cause in supporting and advocating for science. Other…

  5. Science/s.

    Directory of Open Access Journals (Sweden)

    Emmanuelle Tricoire

    2005-03-01

    Full Text Available Un forum a été organisé en mars par la Commission européenne. Il s’appelait « Science in Society ». Depuis 2000 la Commission a mis en place un Plan d’Action élaboré pour que soit promue « la science » au sein du public, afin que les citoyens prennent de bonnes décisions, des décisions informées. Il s’agit donc de développer la réflexivité au sein de la société, pour que cette dernière agisse avec discernement dans un monde qu’elle travaille à rendre durable. ...

  6. Aeromedical Evacuation: Validating Civil Reserve Air Fleet

    Science.gov (United States)

    2009-02-25

    flight nurses and three medical technicians) is added for AE missions. The aeromedical evacuation crew (AEC) may be pared and tailored as required in... Biosecurity and Bioterrorism: Biodefense Strategy, Practice and Science, Volume 5, Number 4, 2007: 319-325. 34 IAT.R 0554 General Accounting Office

  7. The Text of a Regional Co-operative Agreement for Research, Development and Training related to Nuclear Science and Technology. Latest Status. Declarations/Reservations; Texto de un Acuerdo de Cooperacion Regional Para la Investigacion, el Desarrollo y la Capacitacion en Materia de Ciencias y Tecnologia Nucleares

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1972-08-18

    The text of a Regional Co-operative Agreement for Research, Development and Training Related to Nuclear Science and Technology between the Agency and Member States is reproduced herein for the information of all Members. Section 9 thereof specifies the Members that may become party to it [Spanish] Para conocimiento de todos los Estados Miembros en el presente documento se transcribe el texto de un Acuerdo de Cooperacion Regional para la investigacion, el desarrollo y la capacitacion en materia de ciencias y tecnologia nucleares entre el Organismo y los Estados Miembros. En la Seccion 9 se especifican los Estados Miembros que pueden ser partes en el Acuerdo.

  8. OPINIONS ON INTERNATIONAL RESERVES MANAGEMENT - POST CRISIS

    Directory of Open Access Journals (Sweden)

    MERCEA (HANDRO PATRICIA AMALIA

    2017-11-01

    Full Text Available The recent crisis demonstrated once again the importance of maintaining an adequate level of the international reserves as part of the defense of a country against the shocks internationally transmitted. Liquidity buffers aided the good functioning of financial systems, and allowed countries to cope with sudden foreign capital stops or to manage massive outflows without facing a costly crisis. This logic has been strengthened in the context of the crisis from 2008, when countries with lots of reserves, such as China or Brazil, came through better than those with lower liquid assets. Economists have argued that developing countries need reserves mainly to cover urgent imports and short-term debts. The current level of global reserves far exceeds this traditional postulate. In this context, it is necessary to rethink the adequacy of the level of constituting the reserves portfolio. The dominance of the dollar as a reserve currency, another important feature of the current reserves portfolio, makes the holders become vulnerable to the monetary policy of FED. A greater flexibility of the currency will also be needed. The often called the “trilemma” of international economics dictates: when capital is mobile, countries must choose between fixing their currencies and controlling their domestic monetary conditions. They cannot do both. The domestic currency inflexibility will ultimately lead to asset bubbles and inflation. The pressure of capital flows will depend on the prospects of rich economies, especially America’s. The increment of emerging economies availability to allow the exchange rate to move will depend on what China does - and China may remain forever linked to the dollar. The emergence of a global currency that constitute a genuine means of exchange or the use of cross-border multifaceted cash pools common to IMF members would reduce systemic risks. International regulations for countries with persistent trade surpluses could be a

  9. NJS July 2011 for Ogidi.cdr final.cdr

    African Journals Online (AJOL)

    Challenges include poor living conditions, poor accessibility, lack of infrastructure and .... training local staff on specific assignments, as such trained staff have been ... out-sourced at inconvenience and increased costs for the patient. None of ...

  10. NJS July 2011 for Ogidi.cdr final.cdr

    African Journals Online (AJOL)

    We present our experience with this treatment modality over a three ... been called to question in the light of development of less invasive ... Materials and Methods. This is a .... The patient was undergoing dialysis for symptomatic azotemia.

  11. NJS July 2011 for Ogidi.cdr final.cdr

    African Journals Online (AJOL)

    Trauma continues to be a major cause of morbidity and mortality world over. ... rib fracture(s) (23.8%), hemopneumothorax (14.3%), hemothorax (7.1%), ... The mortality rate was 2.4%. Only 7(16.7%) patients were seen beyond the first outpatient clinic appointment. Conclusion. Most patients arriving at the hospital survived, ...

  12. NJS July 2011 for Ogidi.cdr final.cdr

    African Journals Online (AJOL)

    communication skills as a basis for developing an effective education program me. Materials and Method. Residents in the department of surgery were surveyed after a weekly mortality and morbidity meeting. The questionnaire contained 4 demographic items; age, gender, junior or senior registrar and postgraduate year of ...

  13. NJS July 2011 for Ogidi.cdr final.cdr

    African Journals Online (AJOL)

    process and enucleate the nucleus pulposus totally, through an ... 20yrs. 21-. 30yrs. 31-. 40yrs. 41-. 50yrs. 51-. 60yrs. 61-. 70yrs. 71-. 80yrs. Total ..... Gallucci M, Limbucci N, Zugaro L, Barile A,. Stavroulis E ... Systematic review. European ...

  14. Does obesity compromise ovarian reserve markers? A clinician's perspective.

    Science.gov (United States)

    Malhotra, Neena; Bahadur, Anupama; Singh, Neeta; Kalaivani, Mani; Mittal, Suneeta

    2013-01-01

    The aim of the study was to ascertain if increasing body mass index (BMI) adversely affects ovarian reserve among infertile women of Asian origin undergoing in vitro fertilization (IVF). This prospective study on 183 women was carried out in the infertility clinic of All India Institute of Medical Sciences, New Delhi, India. Blood hormonal assay in all patients including follicle-stimulating hormone (FSH), luteinizing hormone (LH) and inhibin B was performed on day 2/3 of a spontaneous cycle. A transvaginal ultrasonographic examination on day 2-5 of the menstrual cycle was done for antral follicle count (AFC) and ovarian volume. A correlation between BMI and ovarian reserve parameters like FSH, LH, inhibin B, antral follicle count and ovarian volume was noted. Age was comparable in the three BMI groups. The mean duration of infertility was 8.38 years. Compared to the normal weight, the overweight and obese women had a statistically significantly low inhibin B (p women had a significantly low AFC (p right side. Incorporating anti-mullerian hormone, a newer marker for ovarian reserve, may benefit these obese infertile women. Further work is required to elucidate the mechanisms underlying the effect of obesity on inhibin B as a marker of ovarian reserve in infertile women. The best marker to check the ovarian reserve is perhaps the woman's performance during an IVF cycle. However, considering the psychological and financial stress of the procedure, it may seem wise to consider counseling of obese women on their expected performance in the first cycle of IVF through such studies.

  15. Pricing of reserves. Valuing system reserve capacity against spot prices in electricity markets

    International Nuclear Information System (INIS)

    Just, Sebastian; Weber, Christoph

    2008-01-01

    This paper models the interdependencies between markets for secondary reserve capacity and spot electricity to derive the pricing of reserves under equilibrium conditions. Starting with the indifference condition between offering in both markets, the reservation price is derived from the opportunity cost consideration and the unit commitment conditions in a fundamental interrelated market framework. The reserve market examined compares widely to the German market for secondary reserves, but the general approach may also be used to investigate other reserve markets. The approach explores and formalizes the influence of reserve capacity on the spot market supply function. A numerical solution procedure is provided to this non-trivial case of market interaction. The model is used to estimate the expected reservation price development over the last years in Germany. (author)

  16. Natural gas reserve growth in Canada

    Energy Technology Data Exchange (ETDEWEB)

    Woronuk, R. [Canadian Gas Potential Committee, Calgary, AB (Canada)]|[GasEnergy Strategies Inc., Calgary, AB (Canada)

    2003-07-01

    An appreciation study of a natural gas reservoir is a component of assessing its ultimate reserve potential. The Canadian Gas Potential Committee (CGPC) defines appreciation as the change in a reserve estimate from a previously booked pool or basin. Basins cannot appreciate through the addition of new pools. Ultimate potential includes all of the following: cumulative production; remaining discovered reserves; adjustments to remaining discovered reserves; and, full appreciated undiscovered reserves. This presentation outlined the procedures used by the CGPC in its appreciation studies. It also reviewed data supplier issues, regulatory practices, and booking issues. A series of graphs were also included depicting pools discovered in 1993 and the average pool gas in place. Reservoir loss from 1993 to 1998 was attributed to the fact that enhanced recovery technology cannot keep pace with the degradation in pool quality. It was noted that beyond 1998, significant increases in gas prices should increase recovery factors. Special studies by the Alberta Energy and Utilities Board have included the depreciation of unconnected gas pools and the appreciation of sheet sands. The challenge of tracking pool appreciation was discussed with reference to estimating new pool discoveries in established fields. 2 tabs., 6 figs.

  17. Pricing the Ramping Reserve and Capacity Reserve in Real Time Markets

    OpenAIRE

    Ye, Hongxing; Li, Zuyi

    2015-01-01

    The increasing penetration of renewable energy in recent years has led to more uncertainties in power systems. In order to maintain system reliability and security, electricity market operators need to keep certain reserves in the Security-Constrained Economic Dispatch (SCED) problems. A new concept, deliverable generation ramping reserve, is proposed in this paper. The prices of generation ramping reserves and generation capacity reserves are derived in the Affine Adjustable Robust Optimizat...

  18. Foreign Exchange Reserves and the Reserve Bank’s Balance Sheet

    OpenAIRE

    Christian Vallence

    2012-01-01

    The Reserve Bank of Australia holds and manages the nation’s foreign exchange reserve assets in order to meet its policy objectives. While Australia’s foreign exchange reserves are relatively modest by international standards, they nonetheless constitute a sizeable portion of the Bank’s balance sheet, and variations in the Australian dollar value of these reserves are usually the most volatile component of the Bank’s profit and loss statement. This article discusses some of the key decisions ...

  19. Science Fiction and Science Education.

    Science.gov (United States)

    Cavanaugh, Terence

    2002-01-01

    Uses science fiction films such as "Jurassic Park" or "Anaconda" to teach science concepts while fostering student interest. Advocates science fiction as a teaching tool to improve learning and motivation. Describes how to use science fiction in the classroom with the sample activity Twister. (YDS)

  20. RESTAURANT RESERVATION MANAGEMENT CONSIDERING TABLE COMBINATION

    Directory of Open Access Journals (Sweden)

    Qing Miao

    Full Text Available ABSTRACT This paper presents a case study of table reservation practice for restaurant business within Walt Disney World. A unique feature here is to consider table combination to capture revenue potentials from different party sizes and at different time periods. For example, a party of large size can be served by combining two or more small tables. A mixed integer programming (MIP model is developed to make the reservation recommendation. We propose a rolling horizon reservation policy such that the value of a particular table is periodically evaluated and updated. This is a typical revenue management method in the airlines and other industries, the essence of which is to compare the future expected revenue with a currently offered price. Using historical data, numerical test shows a significant revenue improvement potential from our proposed model.

  1. Uranium - raw material reserves for coming generations

    International Nuclear Information System (INIS)

    Keutner, H.

    1981-01-01

    Large uranium occurences have been discovered in the South of Mexico. The deposits are situated in the Sierra Mixteca. Reserves of 9.400 tons had been at Mexico's disposal even before these new discoveries. The quantitiy discovered recentyl amounts to 20.000 tons. The uranium reserves available apart from those in centrally controlled economic systems are presently estimated at five million tons. Meanwhile American scientists have found out that all the rivers of the world transport about 16.000 tons of uranium from the continents into the oceans per annum. The energy value of this washed out amount of uranium corresponds to the 25-fold world power demand of today. US scientists have discovered that the oceans can provide uranium for about seven million years of the present world energy demand. While the petroleum reserves decrease worldwide it seems that the exploration of uranium has just been started. (orig.) [de

  2. Wind offering in energy and reserve markets

    DEFF Research Database (Denmark)

    Soares, Tiago; Pinson, Pierre; Morais, Hugo

    2016-01-01

    The increasing penetration of wind generation in power systems to fulfil the ambitious European targets will make wind power producers to play an even more important role in the future power system. Wind power producers are being incentivized to participate in reserve markets to increase...... their revenue, since currently wind turbine/farm technologies allow them to provide ancillary services. Thus, wind power producers are to develop offering strategies for participation in both energy and reserve markets, accounting for market rules, while ensuring optimal revenue. We consider a proportional...... offering strategy to optimally decide upon participation in both markets by maximizing expected revenue from day-ahead decisions while accounting for estimated regulation costs for failing to provide the services. An evaluation of considering the same proportional splitting of energy and reserve in both...

  3. Geoengineering: Basic science and ongoing research efforts in China

    Directory of Open Access Journals (Sweden)

    Long Cao

    2015-09-01

    Full Text Available Geoengineering (also called climate engineering, which refers to large-scale intervention in the Earth's climate system to counteract greenhouse gas-induced warming, has been one of the most rapidly growing areas of climate research as a potential option for tackling global warming. Here, we provide an overview of the scientific background and research progress of proposed geoengineering schemes. Geoengineering can be broadly divided into two categories: solar geoengineering (also called solar radiation management, or SRM, which aims to reflect more sunlight to space, and carbon dioxide removal (CDR, which aims to reduce the CO2 content in the atmosphere. First, we review different proposed geoengineering methods involved in the solar radiation management and carbon dioxide removal schemes. Then, we discuss the fundamental science underlying the climate response to the carbon dioxide removal and solar radiation management schemes. We focus on two basic issues: 1 climate response to the reduction in solar irradiance and 2 climate response to the reduction in atmospheric CO2. Next, we introduce an ongoing geoengineering research project in China that is supported by National Key Basic Research Program. This research project, being the first coordinated geoengineering research program in China, will systematically investigate the physical mechanisms, climate impacts, and risk and governance of a few targeted geoengineering schemes. It is expected that this research program will help us gain a deep understanding of the physical science underlying geoengineering schemes and the impacts of geoengineering on global climate, in particular, on the Asia monsoon region.

  4. Risk spreading, connectivity, and optimal reserve spacing.

    Science.gov (United States)

    Blowes, Shane A; Connolly, Sean R

    2012-01-01

    Two important processes determining the dynamics of spatially structured populations are dispersal and the spatial covariance of demographic fluctuations. Spatially explicit approaches to conservation, such as reserve networks, must consider the tension between these two processes and reach a balance between distances near enough to maintain connectivity, but far enough to benefit from risk spreading. Here, we model this trade-off. We show how two measures of metapopulation persistence depend on the shape of the dispersal kernel and the shape of the distance decay in demographic covariance, and we consider the implications of this trade-off for reserve spacing. The relative rates of distance decay in dispersal and demographic covariance determine whether the long-run metapopulation growth rate, and quasi-extinction risk, peak for adjacent patches or intermediately spaced patches; two local maxima in metapopulation persistence are also possible. When dispersal itself fluctuates over time, the trade-off changes. Temporal variation in mean distance that propagules are dispersed (i.e., propagule advection) decreases metapopulation persistence and decreases the likelihood that persistence will peak for adjacent patches. Conversely, variation in diffusion (the extent of random spread around mean dispersal) increases metapopulation persistence overall and causes it to peak at shorter inter-patch distances. Thus, failure to consider temporal variation in dispersal processes increases the risk that reserve spacings will fail to meet the objective of ensuring metapopulation persistence. This study identifies two phenomena that receive relatively little attention in empirical work on reserve spacing, but that can qualitatively change the effectiveness of reserve spacing strategies: (1) the functional form of the distance decay in covariance among patch-specific demographic rates and (2) temporal variation in the shape of the dispersal kernel. The sensitivity of metapopulation

  5. Optimal drawdown patterns for strategic petroleum reserves

    Energy Technology Data Exchange (ETDEWEB)

    Kuenne, R E; Blankenship, J W; McCoy, P F

    1979-01-01

    An optimization model is described for determining optimal drawdown trajectories for strategic petroleum reserves during an embargo. Development of the model includes the derivation of a GNP response function which relates GNP (used as a measure of social welfare) and crude oil supply reductions. Two alternative forms of this function are used with the model. Simple algorithms are presented which give rapid solutions for the model. The pattern is one of saving some of the reserve to protect against a possible second embargo occurring beforee refill, and of allocating the remainder during the first embargo subperiod so as to equalize monthly marginal benefits. 6 references.

  6. Estimating Quartz Reserves Using Compositional Kriging

    Directory of Open Access Journals (Sweden)

    J. Taboada

    2013-01-01

    Full Text Available The aim of this study was to determine spatial distribution and volume of four commercial quartz grades, namely, silicon metal, ferrosilicon, aggregate, and kaolin (depending on content in impurities in a quartz seam. The chemical and mineralogical composition of the reserves in the seam were determined from samples collected from outcrops, blasting operations, and exploratory drilling, and compositional kriging was used to calculate the volume and distribution of the reserves. A more accurate knowledge of the deposit ensures better mine planning, leading to higher profitability and an improved relationship with the environment.

  7. Challenges in data science

    DEFF Research Database (Denmark)

    Carbone, Anna; Jensen, M.; Sato, Aki-Hiro

    2016-01-01

    of global properties from locally interacting data entities and clustering phenomena demand suitable approaches and methodologies recently developed in the foundational area of Data Science by taking a Complex Systems standpoint. Here, we deal with challenges that can be summarized by the question: "What...... can Complex Systems Science contribute to Big Data? ". Such question can be reversed and brought to a superior level of abstraction by asking "What Knowledge can be drawn from Big Data?" These aspects constitute the main motivation behind this article to introduce a volume containing a collection...... of papers presenting interdisciplinary advances in the Big Data area by methodologies and approaches typical of the Complex Systems Science, Nonlinear Systems Science and Statistical Physics. (C) 2016 Elsevier Ltd. All rights reserved....

  8. Oresajo et al (15).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    2 (2015). SEQUENCE STRATIGRAPHY AND STRUCTURAL ANALYSIS OF THE EMI FIELD,. OFFSHORE ... flooding surfaces, which subdivided the stratigraphic succession within the Emi Field into three depositional sequences. ..... American Association of Petroleum Geologists, ... Africa. U.S. Geological Survey Open-File.

  9. Chemical Data Reporting rule (CDR)

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset contains information on chemicals that company's produce domestically or import into the United States during the principal reporting year. For the 2012...

  10. sept 2 edition 2009.cdr

    African Journals Online (AJOL)

    User

    between 40 and 49 years old. Majority of the study women (98%) were married. Four (4%) of the respondents had learned about pap smear and none knew what Pap smear screened for. None of the respondents had ever had a pap smear taken before. Thirty (30%) of the respondents had heard of the cancer of the cervix.

  11. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    affirm that water is life, also water is necessary for domestic uses like .... these metals can be transported by particulate matters to the sediment which serve as the sink for .... Biomaker of Black Jaw Tilapia From Lagos Lagoon Agrosearch.

  12. Adejoro et al (1).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    band gaps of the complex with different substituents. These properties were obtained ... Keywords: Geometric Parameters, Dipole Moments, Band Gaps Modelling. ABSTRACT. 533 ..... Rhodium and Iron. Complexes and Transition States: A.

  13. Afolabi et al (17).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    and as glaciers and about 4% of the earth's water is present in the ... veins which were exposed in some places by erosion. Figure 1: .... Field VES Curves and Model Parameters of VES 2, VES 1 and VES 3 (from Southeast to. Northwest).

  14. Asaolu et al (16).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    antioxidants, change in gene expression and .... Wistar albino rats of either sex were divided into ... The liver sample (1g) from each rat was transferred .... Table 5: Percentage ABTS Radical Scavenging Activity of Extract and Fractions ofC.

  15. Olorunfemi et al (16).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Oily wastewater pollution not only affects ... control and prevent marine pollution in the ... the Atlantic Ocean in April 2014. ..... Journal of Research in Forestry, Wildlife and ... parameters of River Guma, Benue, ... Emerging risk from ballast water.

  16. RJHS 6(1).cdr

    African Journals Online (AJOL)

    USER

    2018-04-26

    Apr 26, 2018 ... Methods: Fifty PH sessions of 20 minutes each was applied on the subject. Results: On ... Abstrait. Objectifs: Un garçon de quatorze ans a reçu un diagnostic de déficience visuelle de l'œil droit depuis ... Pulmonary Disorder (COPD) (10), Musco- skeletal .... Effect of 'pranic'healing in chronic musculoskeletal.

  17. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    National Programme for Food Security, Nigerian Agricultural Insurance ... Notwithstanding, the impact of this bank is yet to be felt as expected by its target .... indicated that they usually give gifts to credit officers so as to fast-track the farm credit .... nothing bad about it and are more interested in accessing loan than to follow ...

  18. Ajayi and Ogunjobi (10).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    1Dept of Wildlife and Ecotourism Mgt, Federal College of Wildlife Mgt, New Bussa, Niger State ... of the composition of large animals visiting salt lick sites during the day-time at the Borgu ... For effective in-situ wildlife management capable.

  19. PDF-JOURNAL 2006.cdr

    African Journals Online (AJOL)

    also medical benefit and contribute significantly to ... sensation produced by light, invading the eyes as to. 1. 2. 3. 4. 4 ... such as aged related macular degeneration, ... pigment epithelial retinopathy and other retinal or macular problems could benefit from high dose of T. ... gender, refractive error, and occupation from Abia.

  20. Alao and Oludare (5).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Hydrocarbon accumulation resides within the ... the data in various regions of the reservoir and grouping them together ... pay facies allowing for prediction of oil saturation and reservoir ..... Divergent and Passive Margin Basin. American ...

  1. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    Leaf area models are simple, accurate and non-destructive. They are important in many ... area model for S. macrocarpon using linear measurements. A total of 80 fully opened ... Regression analysis of leaf area obtained from graph tracing as ...

  2. Oyebola et al (23).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    3+ described elsewhere (Oyebola et al., 2010). Ho absorption peaks were obtained from transmission studies carried out with a Cary 5000. UV-VIS-NIR spectrophotometer and corresponding absorption coefficients deduced using the Beer-Lambert law. Spectral emission measurements were carried out using the schematic ...

  3. SJVS Draft Vol 9.cdr

    African Journals Online (AJOL)

    HP USER

    Abstract. Endless efforts are required in the investigation of the best organ preservative. Normal Saline, 5% dextrose, Darrows and. Ringers' Lactate were used as preservatives with the view to investigate the prospect of kidney survival in these solutions post harvest at the Veterinary Teaching Hospital, Ahmadu Bello ...

  4. SJVS Draft Vol 9.cdr

    African Journals Online (AJOL)

    HP USER

    2Department of Theriogenology and Animal Production ... male Jack-Russel was presented to the Usmanu Danfodiyo University Veterinary Teaching Hospital, Sokoto .... Animal. Hospital Association. ... Journal of the American Animal Hospital.

  5. Oresajo et al (15).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    3D seismic data, wireline logs from six wells, checkshot and biostratigraphic data were used to subdivide the stratigraphic section within the Emi Field, eastern Niger Delta, into packages of sediments bounded by chronostratigraphically significant surfaces. The results revealed two sequence boundaries and three maximum.

  6. Edegbai and Emofurieta (12).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    ABSTRACT. 131. INTRODUCTION. The Maastrichtian Mamu Formation has been described as a cyclotherm comprising Dark Shale, sandstones and sandy shales (with coal beds at various stratigraphic levels) deposited in a marginal marine environment (tidal flat - estuarine setting; Ladipo, 1988).This Formation exhibits.

  7. Ayeni and Egharevba (14).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    STUDIES OF SOME MORPHOLINO- AND METHYLPIPERAZIN-1-YL MANNICH. LIGANDS AND THEIR ... Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria. *Corresponding ..... Acetophenone. International Journal of.

  8. Okiyi et al (8).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    A geoelectric investigation, involving 1-D Vertical Electrical Sounding (VES) with the Schlumberger array and 2- ... curves were quantitatively interpreted and the results were used for the generation of ..... and Electromagnetic Investigation of.

  9. 4 Hydrogeochemical Framework.cdr

    African Journals Online (AJOL)

    user

    indicates the strength of the mutual relation amongst the hydrochemical ... the world are exposed to health risks due to ... the Bureau of Indian Standards, Drinking ... fluoride concentration in drinking water in ... availability of potable water to these .... regolith is thin or absent, ample ..... drinking water consumption within the.

  10. Jacob et al (21).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    city of Kaduna, Nigeria vis-à-vis the soil physicochemical properties.The city was ... Lead and cadmium, like arsenic and ... danger of soil contamination and to evaluate the impact of waste ..... remediation study of metal contaminated soils with ...

  11. Laniyan et al (16).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Keyword: Arsenic, Absorption, Contamination, Phytoremediation, Filtrates ttlaniyan@yahoo.com ... Arsenic (As) a toxic metal occurs naturally in soil and minerals and may get ..... cadmium toxicity in plants: A review. Environ Pollution. 98(1): ...

  12. Ajayi et al (24).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    In this study, an assessment of the analgesic potential of Zea mays L., Nauclea latifolia Sm leaf; leaf and stalk of. Manihot esculenta Crantz was made. Pain was induced by 0.6% acetic acid in high fat diet-manipulated, alloxan- induced hyperglycaemic rats. Paracetamol® (65 mg/kgBW) served as positive control, while olive ...

  13. African Journal June 2011.cdr

    African Journals Online (AJOL)

    SEGUN ADENIJI

    The fertility trend observed is mainly explained by use of contraception. The contraceptive .... 2005/06 showed that, for the first time in Zimbabwe, the TFR declined to .... this well given a long list of challenges the country is facing? One would ...

  14. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    L) by Gas- ... and lipophilic properties that enable them penetrate rapidly into insects and also interfere with ... essential oils of basil did not lose their viability. ... an eco-friendly alternative to synthetic fumigants in the control of this insect pest.

  15. Fehintola et al (13).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    pollutant were adsorbed from lead, cadmium and .... It is well documented that the essential characteristic of the ..... existence of adsorbent- adsorbate interactions, the heat of ...... bone mineral density in healthy late post- menopausal Dutch ...

  16. Umebese and Fabiyi (4).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    . ... Treatment of stressed plants with SA under chelated Al toxicity (Al + SA + EDTA) improved .... used as a chelate for zinc (Salama etal., 2012). .... Generally, plants subjected to Al+EDTA .... effect of EDTA on the growth of Indian mustard.

  17. RJHS 5(4).cdr

    African Journals Online (AJOL)

    USER

    society the female partners are more willing to per take in ... focused on women without much consideration given to .... probably due to poor knowledge and subsequent .... Divorced. 126. 159. 15. 42.0. 53.0. 5.0. Level of Education No formal.

  18. RJHS 6(1).cdr

    African Journals Online (AJOL)

    USER

    This study aimed at determining the prevalence, sociodemographic features, aetiology, clinical presentation management .... accident, assaults, falls and sports injuries (3,4,7). .... managed with trauma and neurosurgical team. Foreign bodies ...

  19. African Journal June 2011.cdr

    African Journals Online (AJOL)

    SEGUN ADENIJI

    Moroccan population has known a growing demographic trend. ... postnatal care should be enhanced especially towards poor women living in rural areas and ... percentage of married women using contraception .... of births assisted by skilled personnel. 30. 70. 95. % of newly mothers who received antenatal care 40. 71.

  20. yahaya et al.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    bones in Skull of the Camel (Camelus dromendarius) in Nigeria. SUMMARY. The morphological features of facial region of the camel skull were investigated. A total of 42 camel skulls. (30 mature and 12 immature) from three geographical locations. (Maiduguri, Kano and Sokoto) in. Nigeria were used in this study. The.

  1. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    Analytical tools used for the study was Stochastic Frontier. Model (SFM). ..... The maximum likelihood estimates of the parameters of the frontier models for the cultured fish farms are ... The table shows the estimates of regression and variance.

  2. Olorunfemi et al (11).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Keywords: Bilge water, RAPD, DNA damage, Allium cepa, Ships. ABSTRACT. 121 ... component in the socio-economic development of any given maritime .... categories of industries. Lead, copper ... used produced bands between 120 and 1300 bp in length (Plates 1 -5). .... enzyme activities in Allium cepa L. Being a th.

  3. Elueze et al (6).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    OBAJANA MARBLE DEPOSIT IN THE PRECAMBRIAN BASEMENT COMPLEX OF. CENTRAL NIGERIA. 1 .... analyses and physical and mechanical properties determinations. .... bases, construction stone and ornamental stone. The loss on ...

  4. Umukoro et al (4).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    cost adsorbent for the removal of heavy metal ions from wastewaters. Keywords: Adsorption ... specific surface area, high adsorption capacity and special surface chemical .... increasing negative charge density on the adsorbent (Olayinka et ...

  5. RJHS 5(4).cdr

    African Journals Online (AJOL)

    USER

    La maladie rénale chronique constitue un problème de santé publique avec une incidence croissante, une prévalence, de mauvais résultats et un coût élevé. La sensibilisation et le dépistage de l'insuffisance rénale chronique demeurent faibles partout dans le monde. Ainsi, des millions de personnes à travers le monde ...

  6. Oke et al (5).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    River Basin using three empirical formulae which include modified Chaturvedi formula, Krishna Rao ... Keywords: Empirical Formulae; Groundwater Recharge; Ogun River Basin; Oshun River Basin, Inter Item ..... Modeling of Groundwater in.

  7. Okiongbo and Soronnadi (22).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    et al., 1999), evaluation of basin slope stability. (Dugan and ... pore medium. .... F, and takes the clay effects into consideration is c used in this ..... Ha – aquifer thickness from VES data, ρ – pore water resistivity, K – hydraulic conductivity, w.

  8. sept 2 edition 2009.cdr

    African Journals Online (AJOL)

    User

    aspergilloma or complications such as bronchiectasis are also known causes of haemoptysis world wide. However, cystic fibrosis (CF) is the commonest etiologic factor in Europe. Haematemesis may be misinterpreted as haemoptysis, particularly when accurate history is not possible in children. Therefore, bleeding from.

  9. RJHS 5(4).cdr

    African Journals Online (AJOL)

    USER

    breast cancer is associated with high rate of mortality and morbidity. The aim of this study ... Results: During the period of study, 166 females with symptomatic breast lesions had diagnostic .... case use of ultrasonography as an adjunct would.

  10. Cover Final May.cdr

    Indian Academy of Sciences (India)

    user

    tions on the sym bols ofthe initialtext,a sim ple exam ple being to replace each letter ... French Mathematical ... In a visionary paper on the m ilitary cryptography pub- lished in ..... m any years, or decades later, in a com pletely unpre- dictable w ...

  11. RJHS 5(4).cdr

    African Journals Online (AJOL)

    USER

    Abstract. Objectives: The main aim of the study was to explore the influence of family ... assessment device while BMI and blood pressures measures were used to ... number of one-parent mothers had normal BMI (49%) compared to .... self, nuclear family emotional system, family ..... Parenting Style and Family Functioning.

  12. sept 2 edition 2009.cdr

    African Journals Online (AJOL)

    User

    media may go along way to increase contraceptive up take. .... women . The finding of Muslim acceptors being twice their Christian counterpart is a ... Its Social,. Political, Economic, Moral and Religious aspects. Islamic publication Ltd. Lahore.

  13. Dankwah et al (12).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    The optimization of process parameters to give low concentration of acrylamide ... products such as potato chips, deep-fat fried foods, crisp bread ... Factors. Level of Variation. Soaking. H3PO4 /Citric acid. Amount of additive. 0.1 – 1.0 g or mL.

  14. RJHS 5(4).cdr

    African Journals Online (AJOL)

    USER

    everyone will enjoy life at all levels of human endeavor. This statutory ..... sector because of poor electricity, the internet and weak communication .... International Student Edition. Mcgraw-Hill Kogakusha, Ltd, 1960. 5. The Nation, Thursday ...

  15. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    dissemination of antibiotic resistant organisms as well as serve as a reservoir ... The process of transporting these food products from the farm to households ... pattern of bacteria associated with raw vegetables and fruits in the study area, and ...

  16. African Journal June 2011.cdr

    African Journals Online (AJOL)

    SEGUN ADENIJI

    reproductive health services. ... Cet article se sert des données tirées des Enquêtes Démographiques Ghanéennes de 2003 et 2008 ... family planning services and negative attitudes of ..... The vigorous social marketing campaigns carried out.

  17. Adewale et al (18).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    MATERIAL IN SOIL AND MINE TAILINGS OF AWO AND EDE, OSUN-STATE,. NIGERIA. 1*. 1. 2 ... The materials may be original (such as uranium and thorium) or decay .... following equation (Beck et al., 1972). D = 0.042A (K) + 0.429A.

  18. SJVS Draft Vol 9.cdr

    African Journals Online (AJOL)

    HP USER

    Abstract. This paper reports two scenarios whereby goring injury sustained by a Bunaji bull and a Yankasa lamb were managed by pastoralists before the cases were presented to the Large Animal Clinic Unit of the Veterinary Teaching Hospital, Ahmadu. Bello University, Zaria. Anamnesis of the cases presented was that ...

  19. SJVS Draft Vol 9.cdr

    African Journals Online (AJOL)

    HP USER

    Abstract. Blood samples from external jugular vein of camels presented for slaughter at randomly selected slaughter houses in northwestern Nigeria were collected. This is to determine some haematological baseline data and to investigate the influence of pulmonary lesions on the blood parameters studied. Accordingly ...

  20. SJVS Draft Vol 9.cdr

    African Journals Online (AJOL)

    HP USER

    Abstract. Despite the efforts made by stake holders towards eradication of pathogens from poultry flocks, Newcastle disease virus infection is still of continuing economic concern in Nigeria. Consequently, adapting prompt, sensitive and inexpensive diagnostic techniques will without doubt clamp down on the menace of the ...

  1. Ajayi et al (24).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    EXTRACTS IN HIGH FAT DIET-MANIPULATED HYPERGLYCAEMIC RATS. Ajayi, E. I. O.* .... 700 nm (to correct for haze) against a blank cell filled with ... did not suffer any lethal effect or death except two .... of the frequency of phenylquinone-.

  2. African Journal June 2011.cdr

    African Journals Online (AJOL)

    SEGUN ADENIJI

    risk of death and lifelong complications because they are still not well ... Ghanaian cultural and religious settings. This makes it ..... system factors such as attitude of health workers and the ... only contraceptives that provide dual protection form.

  3. Njan et al (9).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    observed for the reaction time to the thermal stimulus. The reaction time .... possess many toxic adverse effects. There is, therefore, a dire ..... Oxide and Nitric Oxide Donors. Pharmacological ... in the mouse without increasing blood pressure.

  4. Akanni et al (11).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Viscosity is a measure of the resistance of one part of a fluid to move ... exponential factor in the Arrhenius equation, E is η. RT. E. A. 303 .2 log log. 10. 10 h h. +. = .... the relationship,. (Feakins, 1974). ..... An empirical formula for the relation ...

  5. Shaibu and Watkins (3).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    compound 1 was oily with 68 % yield. Mass spectra data of compound GL1a, GL1b and GL1c confirmed the proposed structure of the Schiff bases. The spectra mass of three compounds show the molecular ion peak corresponding to theirformulation. The resulting Schiff bases were intensely coloured. The intensities of the ...

  6. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Tosin Bashir

    This paper examines the impact of in ation on economic growth in Sub-Saharan Africa in ... because of the importance of in ation rate in ... ongoing slowdown in private sector credit ..... Optimal in ation for the U.S. economy. ... United States.

  7. 5 Water Quality.cdr

    African Journals Online (AJOL)

    Administrator

    The water quality assessment conducted in the Densu, Birim and Ayensu Basins of Ghana in the Okyeman area ... All the mean nutrient values for Densu, Birim and Ayensu were not significantly .... variability in the composition of the river.

  8. Ezeh et al (17).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Source apportionment results by PCA resolved five sources (Soil dust, 31 %; Sea ... Non-ferrous smelting, 12 %; Heavy oil combustion, 10 %; Biomass burning, 9 %; Sea spray, 6 % ) for PM ..... classified as a non-toxic metal; however exposure.

  9. Idowu et al (19).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    aquifer flow (MacDonald et al., 2005). Typically, it travels vertically downwards through the unsaturated zone to the water table, from where it flows according to the hydraulic gradient, until it reaches an area of discharge where it occurs as springs or seepages, providing part of the dry season flow and constituting part of the.

  10. Falebita et al (4).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    This study evaluated and assessed the organic richness and some ... organic carbon (TOC), thickness, volume of shale (VShale) and effective porosity (PHIE) from wireline logs. ..... A: Thickness vs TOC .... Origin (Source or non-Source) and its.

  11. Abdul et al (9).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    fishery in Nigeria, there is dearth of information on the species' biology in the ... Biometric data such as body weight (BW to the nearest 1 ... This was checked with integrated methods of Pauly (1980). ..... Fisheries Techniques. Bethesda, Amer.

  12. RJHS 5(4).cdr

    African Journals Online (AJOL)

    USER

    Background:Caecal intubation is an important measure of the quality of colonoscopy. Information on the effect of the time of colonoscopy on caecal intubation rate (CIR) is scarce. This study aimed to compare .... CIR had been studied, but information on the .... interval between the start of bowel preparation and the timing of ...

  13. Okonji et al (6).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    +234 806 016 4991, okonjire@yahoo.co.uk; reokonji@oauife.edu.ng. (Received: 26th ... apple, mango, peach, and bitter almonds (ATSDR,. 2006). In plants ... Inc., Benicia Ca., USA. Other chemicals used .... The elution profiles after reactive ...

  14. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Noah Olatoye

    contributions into the scheme, the investment ... Insurance Trust Fund in 1993). .... to the employees and also unload pension liabilities to third parties like insurance companies, and shifts to DC .... thereby increasing economic activities and.

  15. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Tosin Bashir

    emissions and energy consumption to economic growth and strong unidirectional causality running from CO2 emissions, energy ..... Estimating the environmental Kuznets curve for Spain by considering ... In uences of indirect lifestyle aspects.

  16. African Journal June 2011.cdr

    African Journals Online (AJOL)

    SEGUN ADENIJI

    Pregnancy rates were higher in day 3 group (55/131, 42%) when compared to ... insemination or ICSI) of pronuclear morphology as a predictor of ... until the time of the transfer. Embryos were ..... A (2001) The effect of pronuclear morphology ...

  17. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    Mean. Std.Dev. Minimum. Maximum. Output in (kg). 2206.4. 933.47. 650. 5000. Pond size (cm2). 807.8 ... Table 3: Stochastic frontier estimates for catfish production in Ijumu LGA. Variables. Parameter ... Variance Parameter. Sigma square δ2.

  18. Adeoye et al (5).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    2 (2015). HAEMATOLOGY AND SERUM BIOCHEMISTRY OF F AND F PIGS PRODUCED BY. 1 ... Animal Production and Health, Federal University, Katsina State. ABSTRACT ... volume and haemoglobin of guinea fowl, with the male having ...

  19. Akinlabi et al (10).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    VES 12. VES 11. VES 10. VES 9. VES 8. VES 7. RIVER. CHANNEL. BH01. BH02. BH03. BH04. BH05. BH06. 1833. 2592. 4272. 4161. 3025. 2687. 708. 562. 265. 1272. 734. 2989. 9270. Geoelectrical interface. Lithologic interface. Distance along dam axis(m). Resistivity value in ohm-m. Borehole point. VES station. CH 100.

  20. 1 Ecosystem-based.cdr

    African Journals Online (AJOL)

    Administrator

    Abstract. The ecosystem approach is a widely accepted framework for natural resource ... Here, we present a set of indicators, and a toolkit to aid their application, that are intended to support the ... Ability to adapt to different spatial scales ... growth of plants and algae, which may increase to create .... taxonomic resources).

  1. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Tosin Bashir

    improvements in manufacturing and trade activities, which ... Product (GDP) recorded a slight improvement within the period ... tenor of the forward sales cycle from 180 days to 30 days ... decrease in Foreign Direct Investment (FDI) and other ...

  2. Adekunle et al (8).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    BIODEGRADATION OF PETROLEUM OILS BY FUNGI ISOLATED FROM OIL ... compounds which possesses a measurable toxicity towards ... indigenous organisms, including oil-degrading ... papers were dipped in 250 ml crude oil contained.

  3. Laniyan et al (1).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Pollution of groundwater has become a major environmental problem. Anthropogenic ... drinking water comes from aquifers (Forster et al.,. 1998). Aquifers ... improvement in public health. ..... Arsenic (As): Chemical properties,. Health and ...

  4. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Tosin Bashir

    with equally huge market given its population size-180 million. ... industrialization as speci ed in the Economic Recovery and Growth Plan (ERGP), the .... industry lacks a strong and positive brand image among consumers and investors, as.

  5. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    In Nigeria, genotype by environment interaction effect on maize grain yield is ... This is because growing of high yielding and stable maize ... flexibility in planting dates which enables multiple plantings to spread the risk of crop failure due to ... includes analysis of variance followed by a joint regression (JR) analysis to ...

  6. Asowata et al (10).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Thirty six river sediment samples were collected from Ala River, Akure, and were ... activities such as vehicle related workshops, road junctions, municipal waste, abattoir and farm gardens were ... The toxicological risks of consumption of water.

  7. RJHS 6(1).cdr

    African Journals Online (AJOL)

    USER

    2018-04-24

    Apr 24, 2018 ... both days and the unit the patient was managed; the type of surgery done and the age ... entre les valeurs de l'hématocrite sur les deux jours et l'unité du patient a été géré; le type de chirurgie .... Human Coagulation Factors.

  8. RJHS 6(1).cdr

    African Journals Online (AJOL)

    USER

    2018-04-27

    Apr 27, 2018 ... Butanol extract of Manihot esculenta leaf modulated cigarette butt ... Manihot esculenta leaf, in vivo, and against the effects of cigarette butt leachate, in vitro on liver ..... Novotny T. E., Lum K. and Smith E. Cigarettes butts and ...

  9. Oke et al (3).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    β Postgraduate Student in Department of Civil Engineering, Obafemi Awolowo University, Ile-Ife, Nigeria ... The study revealed that flow in pipe network analysis varied with the method. The flow was a ...... Applied Hydraulic ... Chem Eng Sci.

  10. PDF-JOURNAL 2006.cdr

    African Journals Online (AJOL)

    eyes equally; functions mostly affected include ... and 30 after which it decreases as a function of age, colour vision and visual fields also diminish with age. ... up around 7-8 years of age. ... increased depth of focus induced by senile and.

  11. sept 2 edition 2009.cdr

    African Journals Online (AJOL)

    User

    treatment of hyperparathyroidism and the remaining 9 cases diagnosed during the management of thyroid disorders or cervical nodules . These authors have therefore suggested that the old dictum stating that lateral aberrant thyroid represents metastatic cancer should be either modified or removed in review texts and.

  12. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Tosin Bashir

    Among many other nancing models, Public-Private. Partnerships ... Integrated Infrastructure Master Plan (NIIMP), enactment of PPP legislation and implementation support ... is expected to operate as a PPP to the tune of ... This company was.

  13. The naturalism of the sciences.

    Science.gov (United States)

    Dawes, Gregory W; Smith, Tiddy

    2018-02-01

    The sciences are characterized by what is sometimes called a "methodological naturalism," which disregards talk of divine agency. In response to those who argue that this reflects a dogmatic materialism, a number of philosophers have offered a pragmatic defense. The naturalism of the sciences, they argue, is provisional and defeasible: it is justified by the fact that unsuccessful theistic explanations have been superseded by successful natural ones. But this defense is inconsistent with the history of the sciences. The sciences have always exhibited what we call a domain naturalism. They have never invoked divine agency, but have always focused on the causal structure of the natural world. It is not the case, therefore, that the sciences once employed theistic explanations and then abandoned them. The naturalism of the sciences is as old as science itself. Copyright © 2018 Elsevier Ltd. All rights reserved.

  14. 40 CFR 80.605 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false [Reserved] 80.605 Section 80.605 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Motor Vehicle Diesel Fuel; Nonroad, Locomotive, and Marine Diesel Fuel; and ECA...

  15. 40 CFR 80.609 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false [Reserved] 80.609 Section 80.609 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Motor Vehicle Diesel Fuel; Nonroad, Locomotive, and Marine Diesel Fuel; and ECA...

  16. 40 CFR 80.534 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false [Reserved] 80.534 Section 80.534 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Motor Vehicle Diesel Fuel; Nonroad, Locomotive, and Marine Diesel Fuel; and ECA...

  17. 40 CFR 407.43 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 407.43 Section 407.43 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED FRUITS AND VEGETABLES PROCESSING POINT SOURCE CATEGORY Frozen Potato Products...

  18. 40 CFR 407.63 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 407.63 Section 407.63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED FRUITS AND VEGETABLES PROCESSING POINT SOURCE CATEGORY Canned and Preserved Fruits...

  19. 40 CFR 407.23 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 407.23 Section 407.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED FRUITS AND VEGETABLES PROCESSING POINT SOURCE CATEGORY Apple Products Subcategory...

  20. 40 CFR 407.33 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 407.33 Section 407.33 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED FRUITS AND VEGETABLES PROCESSING POINT SOURCE CATEGORY Citrus Products Subcategory...