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Sample records for schrift bliss korrespondenz

  1. Knowledge Is BLISS: An Investigation into the Transparency of BLISS Symbol Strings Directed by a Person with Aphasia

    Science.gov (United States)

    O'Donnell, Tony; Bruce, Carolyn; Black, Maria; Clayton, Amanda

    2010-01-01

    Background: Since his stroke 15 years ago, Tony O'Donnell has worked with BLISS, a symbolic, graphical language. BLISS has been used with a variety of clinical populations, including people with severe aphasia. O'Donnell found his adapted version of BLISS was meaningful to him when spoken and written English was not. The present study is part of a…

  2. Microgrid Enabled Distributed Energy Solutions (MEDES) Fort Bliss Military Reservation

    Science.gov (United States)

    2014-02-01

    FINAL REPORT Microgrid Enabled Distributed Energy Solutions (MEDES) Fort Bliss Military Reservation ESTCP Project EW-201140 FEBRUARY...TITLE AND SUBTITLE Microgrid Enabled Distributed Energy Solutions (MEDES) 5a. CONTRACT NUMBER W912HQ-11-C-0082 Fort Bliss, Texas...Lockheed Martin’s Intelligent Microgrid Solution can provide more energy security while also lowering electric utility costs and greenhouse gas emissions

  3. Bastion on the Border: Fort Bliss, 1854-1943

    Science.gov (United States)

    1993-01-01

    Journals , Record Group (RG) 165, Records of the War Department General and Special Staffs, National Archives, Washington, D.C. "’Richard Estrada, Border...it was the Fort Bliss garrison and the other troops deployed by Steever in the El Paso Patrol District that would have to provide the figurative glue ...little military value. For example, on March 30 three carloads of oats, flour , corn, and hay were dispatched; on April 7 fourteen carloads of hay, gasoline

  4. 75 FR 52733 - Record of Decision (ROD) for Fort Bliss Army Growth and Force Structure Realignment

    Science.gov (United States)

    2010-08-27

    ... decrease in certain quality of life indicators (e.g., traffic, air quality). The ROD, FEIS and other environmental documents are available on the Fort Bliss Web site ( http://www.bliss.army.mil ) or at the... (Stationing Action Alternative 4); land use changes that allow fixed site bivouac areas, mission support...

  5. Henry Evelyn Bliss--The Other Immortal, or a Prophet without Honour?

    Science.gov (United States)

    Broughton, Vanda

    2008-01-01

    The paper takes a retrospective look at the work of Henry Evelyn Bliss, classificationist theorist and author of the "Bibliographic Classification". Major features of his writings and philosophy are examined and evaluated for the originality of their contribution to the corpus of knowledge in the discipline. Reactions to Bliss's work are analysed,…

  6. Von Braun Rocket Team at Fort Bliss, Texas

    Science.gov (United States)

    1940-01-01

    The German Rocket Team, also known as the Von Braun Rocket Team, poses for a group photograph at Fort Bliss, Texas. After World War II ended in 1945, Dr. Wernher von Braun led some 120 of his Peenemuende Colleagues, who developed the V-2 rocket for the German military during the War, to the United Sttes under a contract to the U.S. Army Corps as part of Operation Paperclip. During the following five years the team worked on high altitude firings of the captured V-2 rockets at the White Sands Missile Range in New Mexico, and a guided missile development unit at Fort Bliss, Texas. In April 1950, the group was transferred to the Army Ballistic Missile Agency (ABMA) at Redstone Arsenal in Huntsville, Alabama, and continued to work on the development of the guided missiles for the U.S. Army until transferring to a newly established field center of the National Aeronautic and Space Administration (NASA), George C. Marshall Space Flight Center (MSFC).

  7. 75 FR 24930 - Fort Bliss (Texas) Army Growth and Force Structure Realignment Final Environmental Impact...

    Science.gov (United States)

    2010-05-06

    ...-PWE, Building 624, Taylor Road, Fort Bliss, TX 79916-6812; e- mail: [email protected] . FOR... Regional Branch Library, 551 Redd Road. In Las Cruces (NM), the New Mexico State University Zuhl Library...

  8. Exploration Drilling and Technology Demonstration At Fort Bliss

    Energy Technology Data Exchange (ETDEWEB)

    Barker, Ben; Moore, Joe [EGI; Segall, Marylin; Nash, Greg; Simmons, Stuart; Jones, Clay; Lear, Jon; Bennett, Carlon

    2014-02-26

    The Tularosa-Hueco basin in south-central New Mexico has long been known as an extensional area of high heat flow. Much of the basin is within the Fort Bliss military reservation, which is an exceptionally high value customer for power independent of the regional electric grid and for direct use energy in building climate control. A series of slim holes drilled in the 1990s established the existence of a thermal anomaly but not its practical value. This study began in 2009 with a demonstration of new exploration drilling technology. The subsequent phases reported here delivered a useful well, comparative exploration data sets and encouragement for further development. A production-size well, RMI56-5, was sited after extensive study of archival and newly collected data in 2010-2011. Most of 2012 was taken up with getting state and Federal authorities to agree on a lead agency for permitting purposes, getting a drilling permit and redesigning the drilling program to suit available equipment. In 2013 we drilled, logged and tested a 924 m well on the McGregor Range at Fort Bliss using a reverse circulation rig. Rig tests demonstrated commercial permeability and the well has a 7-inch slotted liner for use either in production or injection. An August 2013 survey of the completed well showed a temperature of 90 C with no reversal, the highest such temperature in the vicinity. The well’s proximity to demand suggests a potentially valuable resource for direct use heat and emergency power generation. The drilling produced cuttings of excellent size and quality. These were subjected to traditional analyses (thin sections, XRD) and to the QEMScan™ for comparison. QEMScan™ technology includes algorithms for determining such properties of rocks as density, mineralogy, heavy/light atoms, and porosity to be compared with direct measurements of the cuttings. In addition to a complete cuttings set, conventional and resistivity image logs were obtained in the open hole before

  9. Otázka slobodnej vôle v helenistickej filozofii (na pozadí Ciceronovho spisu De fato (Die Frage des freien Willens in der hellenistischen Philosophie (In Anbetracht der Ciceros Schrift De fato

    Directory of Open Access Journals (Sweden)

    Peter Fraňo

    2010-06-01

    Full Text Available In diesem Beitrag ich beschäftige mich mit der Frage: Ist das menschliche handeln vorbestimmt, oder kann der Einzelne frei entscheiden? Diese problematik wurde in der hellenistischen Philosophie sehr verbreitet. Das erste mal hat diese Frage Aristoteles in seinen Werken: Die Nikomachische Etik und vor allem De Interpretatione erforscht, wo hat sich die logische Problematik des sogenannten περὶ δυνατῶν berührt. Die megarischen Philosophen Diodoros Kronos und Philon von Megara hat auf die Lösung des Aristoteles reagiert. Außer der Logik ist die Problematik des freien Willes der Bestandteil der stoischen Physik (Astrologie, Sympathie uns stoische Ursachen gewesen. In meinem Beitrag ich habe auf diese Gesichtspunkte in Anbetracht der Ciceros Schrift De fato hingewiesen.

  10. The bliss (not the problem) of motor abundance (not redundancy).

    Science.gov (United States)

    Latash, Mark L

    2012-03-01

    Motor control is an area of natural science exploring how the nervous system interacts with other body parts and the environment to produce purposeful, coordinated actions. A central problem of motor control-the problem of motor redundancy-was formulated by Nikolai Bernstein as the problem of elimination of redundant degrees-of-freedom. Traditionally, this problem has been addressed using optimization methods based on a variety of cost functions. This review draws attention to a body of recent findings suggesting that the problem has been formulated incorrectly. An alternative view has been suggested as the principle of abundance, which considers the apparently redundant degrees-of-freedom as useful and even vital for many aspects of motor behavior. Over the past 10 years, dozens of publications have provided support for this view based on the ideas of synergic control, computational apparatus of the uncontrolled manifold hypothesis, and the equilibrium-point (referent configuration) hypothesis. In particular, large amounts of "good variance"-variance in the space of elements that has no effect on the overall performance-have been documented across a variety of natural actions. "Good variance" helps an abundant system to deal with secondary tasks and unexpected perturbations; its amount shows adaptive modulation across a variety of conditions. These data support the view that there is no problem of motor redundancy; there is bliss of motor abundance.

  11. Historical Analysis of Land Cover/Condition Trends at Fort Bliss, Texas, Using Remotely Sensed Imagery

    National Research Council Canada - National Science Library

    Tweddale, Scott

    2001-01-01

    .... They need a cost-effective method of assessing and monitoring land condition. The objective of this research was to characterize the small scale, gross level change in land condition on a selected area of Fort Bliss over a 23-year period...

  12. A Case Analysis of Energy Savings Performance Contract Projects and Photovoltaic Energy at Fort Bliss, El Paso, Texas

    Science.gov (United States)

    2006-06-01

    PHOTOVOLTAIC ENERGY AND FORT BLISS CASE BACKGROUND A. PHOTOVOLTAIC ENERGY The use of photovoltaic power systems is nothing new in the Department...against the Outback MPPT charge controller . This test will be done over a one month timeframe. The Arizona Power ISG test plan is contained in...cost-benefit analysis of conventional power versus emerging photovoltaic energy for the Army’s Fort Bliss in El Paso, TX. The project will also analyze

  13. On the (Impossibility and Bliss of Telling My Dad, "I Love You"

    Directory of Open Access Journals (Sweden)

    Daniel Wade Clarke

    2018-05-01

    Full Text Available While fathers seldom say "I love you" to their son(s, there is also acknowledgment that sons rarely say it to their father. Confessions of love are like notes in a melody of previous affirmations, so what is it like for a son to say it, especially if large parts of his life are spent in "connective avoidance" with his dad? Writing on the (impossibility of eventually saying "I love you," just before he died, I offer a "blissfully poetic" account of the experience of saying it. I also reflect on the lingering significance it has had for my experience of loss and bereavement. Although this text offers no easy formula, it ends by showing what a text of bliss might eventually look like for a son in recovery. Addressing the questions, so what? And, now what, then? implications beyond the self are also considered.

  14. Energy Optimization Assessment at U.S. Army Installations: Fort Bliss, TX

    Science.gov (United States)

    2008-09-01

    Log dampers, temperatures, actuator signals, and other parameters to identify problems. Adjust chiller and boiler setpoints and control curves...installation. The lowest setpoints were found in the Centennial Club, with 52 °F during unoccupied hours (morn- ing). The chillers ran pretty much fully loaded...ER D C/ CE R L TR -0 8 -1 5 Energy Optimization Assessment at U.S. Army Installations Fort Bliss, TX David M. Underwood, Alexander M

  15. Ultra-Sensitive Transition-Edge Sensors for the Background Limited Infrared/Sub-mm Spectrograph (BLISS)

    Science.gov (United States)

    Beyer, A. D.; Kenyon, M. E.; Echternach, P. M.; Chui, T.; Eom, B.-H.; Day, P. K.; Bock, J. J.; Holmes, W.A.; Bradford, C. M.

    2011-01-01

    We report progress in fabricating ultra-sensitive superconducting transition-edge sensors (TESs) for BLISS. BLISS is a suite of grating spectrometers covering 35-433 micron with R approx. 700 cooled to 50 mK that is proposed to fly on the Japanese space telescope SPICA. The detector arrays for BLISS are TES bolometers readout with a time domain SQUID multiplexer. The required noise equivalent power (NEP) for BLISS is NEP = 10(exp -19) W/Hz(exp 1/2) with an ultimate goal of NEP= 5 x 10(exp -20) W/Hz(exp 1/2) to achieve background limited noise performance. The required and goal response times are tau = 150 ms and tau = 50ms respectively to achieve the NEP at the required and goal optical chop frequency 1-5 Hz. We measured prototype BLISS arrays and have achieved NEP = 6 x 10(exp -18) W/Hz(exp 1/2) and tau = 1.4 ms with a Ti TES (T(sub C) = 565 mK) and NEP approx. 2.5 x 10(exp -19) W/Hz(exp 1/2) and tau approximates 4.5 ms with an Ir TES (T(sub C) = 130 mK). Dark power for these tests is estimated at 1-5 fW.

  16. Dust Plume Modeling from Ranges and Maneuver Areas on Fort Bliss and the White Sands Missile Range: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Chapman, Elaine G.; Barnard, James C.; Rutz, Frederick C.; Pekour, Mikhail S.; Rishel, Jeremy P.; Shaw, William J.

    2009-05-04

    The potential for air quality impacts from heavy mechanized vehicles operating on and between the unpaved main supply routes at Fort Bliss and White Sands Missile Range was investigated. This report details efforts by the staff of Pacific Northwest National Laboratory for the Fort Bliss Directorate of Environment in this investigation. Dust emission and dispersion from typical move-out activities occurring on the installations were simulated using the atmospheric modeling system DUSTRAN. Major assumptions associated with designing the modeling scenarios are summarized and results of simulations conducted under these assumptions are presented for four representative meteorological periods.

  17. Achieving BLISS: Challenges for Building Fast, Ultra-Sensitive Transition-Edge Sensors

    Science.gov (United States)

    Beyer, Andrew D.; Runyan, M. C.; Kenyon, M.; Echternach, P. M .; Chui, T.; Bumble, B.; Bradford, C. M.; Holmes, W. A.; Bock, J. J.

    2012-01-01

    Topics: 1.Motivation and Intro to TESs. 2. BLISS Specifications-tolerance to dark power. 3.Measuring stray (dark) power-Tc (alpha) and G measurements. a) Overview two methods: JTD vs. TES. b) TES arrays: measurement and complications for Pd, Tc, and alpha. 4. Results: Pd compare, NEP, tau, 1/f issues. LIRGs and ULIRGs: Excellent example of distinct optical/UV and IR luminosity. Interaction long known, but huge luminosity is not predicted based on optical studies. (greater than 90% of the energy is emitted at in the far-IR). Large luminosity has both starburst and accretion components.

  18. Antimicrobial combinations: Bliss independence and Loewe additivity derived from mechanistic multi-hit models

    Science.gov (United States)

    Yu, Guozhi; Hozé, Nathanaël; Rolff, Jens

    2016-01-01

    Antimicrobial peptides (AMPs) and antibiotics reduce the net growth rate of bacterial populations they target. It is relevant to understand if effects of multiple antimicrobials are synergistic or antagonistic, in particular for AMP responses, because naturally occurring responses involve multiple AMPs. There are several competing proposals describing how multiple types of antimicrobials add up when applied in combination, such as Loewe additivity or Bliss independence. These additivity terms are defined ad hoc from abstract principles explaining the supposed interaction between the antimicrobials. Here, we link these ad hoc combination terms to a mathematical model that represents the dynamics of antimicrobial molecules hitting targets on bacterial cells. In this multi-hit model, bacteria are killed when a certain number of targets are hit by antimicrobials. Using this bottom-up approach reveals that Bliss independence should be the model of choice if no interaction between antimicrobial molecules is expected. Loewe additivity, on the other hand, describes scenarios in which antimicrobials affect the same components of the cell, i.e. are not acting independently. While our approach idealizes the dynamics of antimicrobials, it provides a conceptual underpinning of the additivity terms. The choice of the additivity term is essential to determine synergy or antagonism of antimicrobials. This article is part of the themed issue ‘Evolutionary ecology of arthropod antimicrobial peptides’. PMID:27160596

  19. Antimicrobial combinations: Bliss independence and Loewe additivity derived from mechanistic multi-hit models.

    Science.gov (United States)

    Baeder, Desiree Y; Yu, Guozhi; Hozé, Nathanaël; Rolff, Jens; Regoes, Roland R

    2016-05-26

    Antimicrobial peptides (AMPs) and antibiotics reduce the net growth rate of bacterial populations they target. It is relevant to understand if effects of multiple antimicrobials are synergistic or antagonistic, in particular for AMP responses, because naturally occurring responses involve multiple AMPs. There are several competing proposals describing how multiple types of antimicrobials add up when applied in combination, such as Loewe additivity or Bliss independence. These additivity terms are defined ad hoc from abstract principles explaining the supposed interaction between the antimicrobials. Here, we link these ad hoc combination terms to a mathematical model that represents the dynamics of antimicrobial molecules hitting targets on bacterial cells. In this multi-hit model, bacteria are killed when a certain number of targets are hit by antimicrobials. Using this bottom-up approach reveals that Bliss independence should be the model of choice if no interaction between antimicrobial molecules is expected. Loewe additivity, on the other hand, describes scenarios in which antimicrobials affect the same components of the cell, i.e. are not acting independently. While our approach idealizes the dynamics of antimicrobials, it provides a conceptual underpinning of the additivity terms. The choice of the additivity term is essential to determine synergy or antagonism of antimicrobials.This article is part of the themed issue 'Evolutionary ecology of arthropod antimicrobial peptides'. © 2016 The Author(s).

  20. 77 FR 32625 - William J. Stevenson, Estate of Lynn E. Stevenson, Black Canyon Bliss, LLC; Notice of Application...

    Science.gov (United States)

    2012-06-01

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 8866-010] William J. Stevenson, Estate of Lynn E. Stevenson, Black Canyon Bliss, LLC; Notice of Application for Transfer of License, and Soliciting Comments and Motions To Intervene On April 23, 2012, William J. Stevenson, Estate...

  1. 76 FR 20652 - Idaho Power Company; Notice of Application of Land Management Plan Update for the Bliss, Upper...

    Science.gov (United States)

    2011-04-13

    ... projects are located in south-central Idaho on the Snake River from river mile 551 near Bliss to river mile... and reproduction at the Commission's Public Reference Room, located at 888 First Street, NE., Room [email protected] , for TTY, call (202) 502-8659. A copy is also available for inspection and reproduction at...

  2. Modification of the Hottel-Whillier-Bliss equation for cover absorption effects in solar collectors

    Energy Technology Data Exchange (ETDEWEB)

    Wijeysundera, N E

    1981-01-01

    The effects of solar radiation absorption and the thermal resistance of a solar collector cover system on the various factors which occur in the Hottel-Whillier-Bliss (HWB) equation are considered. It is shown that by extending the thermal network analogy to systems with distributed heat sources, the heat transfer analysis of the collector can be done with little computational effort. The analysis also leads to a simple form of the HWB equation, with additional factors to account for the source distribution and the thermal resistance of the cover system, and it is applicable to conventional flat plate collectors and to other thermal trap collectors. A series of calculations for multilayer systems is presented to show the relative importance of the various factors in the modified HWB equation for different cover configurations.

  3. A Comparison of BLISS and PLD on Low-SNR WASP-29b Spitzer Observations

    Science.gov (United States)

    Challener, Ryan; Harrington, Joseph; Cubillos, Patricio E.; Blecic, Jasmina; Deming, Drake; Hellier, Coel

    2018-01-01

    We present an analysis of Spitzer secondary eclipse observations of exoplanet WASP-29b. WASP-29b is a Saturn-sized, short-period exoplanet with mass 0.24 ± 0.02 Jupiter masses and radius 0.84 ± 0.06 Jupiter radii (Hellier et al., 2010). We measure eclipse depths and midpoints using our Photometry for Orbits, Eclipses, and Transits (POET) code, which does photometry and light-curve modeling with a BiLinearly Interpolated Subpixel Sensitivity (BLISS) map, and our Zen Eliminates Noise (ZEN) code, which takes POET photometry and applies Pixel-Level Decorrelation (PLD). BLISS creates a physical map of pixel gain variations, and is thereby independent of any astrophysical effects. PLD takes a mathematical approach, using relative variations in pixel values near the target to eliminate position-correlated noise. The results are consistent between the methods, except in one outlier observation where neither model could effectively remove correlated noise in the light curve. Using the eclipse timings, along with previous transit observations and radial velocity data, we further refine the orbit of WASP-29b, and, when excluding the outlier, determine an eccentricity between 0.037 and 0.056. We performed atmospheric retrieval with our Bayesian Atmospheric Radiative Transfer (BART) code but find that, when the outlier is discarded, the planet is consistent with a blackbody, and molecular abundances cannot be constrained. This work is based on observations made with the Spitzer Space Telescope, which is operated by the Jet Propulsion Laboratory, California Institute of Technology under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

  4. Bi-Level Integrated System Synthesis (BLISS) for Concurrent and Distributed Processing

    Science.gov (United States)

    Sobieszczanski-Sobieski, Jaroslaw; Altus, Troy D.; Phillips, Matthew; Sandusky, Robert

    2002-01-01

    The paper introduces a new version of the Bi-Level Integrated System Synthesis (BLISS) methods intended for optimization of engineering systems conducted by distributed specialty groups working concurrently and using a multiprocessor computing environment. The method decomposes the overall optimization task into subtasks associated with disciplines or subsystems where the local design variables are numerous and a single, system-level optimization whose design variables are relatively few. The subtasks are fully autonomous as to their inner operations and decision making. Their purpose is to eliminate the local design variables and generate a wide spectrum of feasible designs whose behavior is represented by Response Surfaces to be accessed by a system-level optimization. It is shown that, if the problem is convex, the solution of the decomposed problem is the same as that obtained without decomposition. A simplified example of an aircraft design shows the method working as intended. The paper includes a discussion of the method merits and demerits and recommendations for further research.

  5. Bliss and Loewe interaction analyses of clinically relevant drug combinations in human colon cancer cell lines reveal complex patterns of synergy and antagonism.

    Science.gov (United States)

    Kashif, Muhammad; Andersson, Claes; Mansoori, Sharmineh; Larsson, Rolf; Nygren, Peter; Gustafsson, Mats G

    2017-11-28

    We analyzed survival effects for 15 different pairs of clinically relevant anti-cancer drugs in three iso-genic pairs of human colorectal cancer carcinoma cell lines, by applying for the first time our novel software (R package) called COMBIA. In our experiments iso-genic pairs of cell lines were used, differing only with respect to a single clinically important KRAS or BRAF mutation. Frequently, concentration dependent but mutation independent joint Bliss and Loewe synergy/antagonism was found statistically significant. Four combinations were found synergistic/antagonistic specifically to the parental (harboring KRAS or BRAF mutation) cell line of the corresponding iso-genic cell lines pair. COMBIA offers considerable improvements over established software for synergy analysis such as MacSynergy™ II as it includes both Bliss (independence) and Loewe (additivity) analyses, together with a tailored non-parametric statistical analysis employing heteroscedasticity, controlled resampling, and global (omnibus) testing. In many cases Loewe analyses found significant synergistic as well as antagonistic effects in a cell line at different concentrations of a tested drug combination. By contrast, Bliss analysis found only one type of significant effect per cell line. In conclusion, the integrated Bliss and Loewe interaction analysis based on non-parametric statistics may provide more robust interaction analyses and reveal complex patterns of synergy and antagonism.

  6. EFECTO DE FECHA Y TIPO DE PODA EN FRAMBUESA ROJA 'Malling autumn Bliss'

    Directory of Open Access Journals (Sweden)

    R. Á. Parra-Quezada

    2007-01-01

    Full Text Available Se estudiaron fechas de poda al ras del suelo y despuntes en frambuesa roja 'Malling autumn Bliss', en Guerrero, Chihuahua, con el objetivo de conocer los efectos en el crecimiento de los tallos nuevos, periodo de cosecha, rendimiento y calidad de fruta. Se utilizaron plantas de un año de edad y durante el 2001 se realizaron podas al ras del suelo el 15 de marzo, 15 de abril y 15 de mayo, así como poda de despunte el 15 de marzo del mismo año y el testigo sin despuntar y sin poda. En el 2002 se evaluaron podas al ras el 15 de marzo, 15 de abril y el 15 de mayo. En ambos años se utilizaron cuatro repeticiones y unidades experimentales de dos metros de longitud. El distanciamiento entre hileras fue de 1.5 m y se formaron setos de 60 cm de ancho. Antes de la plantación (abril del 2000, el terreno se barbechó y se incorporaron con rastra entre los 10 y 15 cm de profundidad 60 ton·ha-1 de estiércol bovino seco como única fuente nutrimental al cultivo. El sistema de riego fue por goteo superficial, con goteros cada metro. La poda al ras del 15 de abril presentó el mayor rendimiento con 7.4 y 5.0 t·ha-1 en el 2001 y 2002, respectivamente. La poda al ras el 15 de mayo retrasa la fecha de floración y la cosecha en ambos años. La floración de frambuesa evade las heladas tardías. La producción se concentró de agosto a octubre. El número de nuevos tallos por metro lineal fue superior en la poda al ras del 15 de abril. Los frutos de mayor tamaño se produjeron en la poda al ras del 15 de marzo y el 15 de abril y va de 1.8 a 3.6 g por fruto. Se observa una tendencia de disminución de rendimiento conforme pasan los años de producción.

  7. El Paso County Geothermal Project at Fort Bliss. Final Project Report

    Energy Technology Data Exchange (ETDEWEB)

    Lear, Jon [Ruby Mountain Inc., Salt Lake City, UT (United State); Bennett, Carlon [Ruby Mountain Inc., Salt Lake City, UT (United State); Lear, Dan [Ruby Mountain Inc., Salt Lake City, UT (United State); Jones, Phil L. [Ruby Mountain Inc., Salt Lake City, UT (United State); Burdge, Mark [Evergreen Clean Energy Management, Provo, UT (United States); Barker, Ben [Evergreen Clean Energy Management, Provo, UT (United States); Segall, Marylin [Univ. of Utah, Salt Lake City, UT (United States). Energy and Geoscience Inst.; Moore, Joseph [Univ. of Utah, Salt Lake City, UT (United States). Energy and Geoscience Inst.; Nash, Gregory [Univ. of Utah, Salt Lake City, UT (United States). Energy and Geoscience Inst.; Jones, Clay [Univ. of Utah, Salt Lake City, UT (United States). Energy and Geoscience Inst.; Simmons, Stuart [Univ. of Utah, Salt Lake City, UT (United States). Energy and Geoscience Inst.; Taylor, Nancy [Univ. of Utah, Salt Lake City, UT (United States). Energy and Geoscience Inst.

    2016-02-01

    The El Paso County Geothermal Project at Fort Bliss was an effort to determine the scale and scope of geothermal resources previously identified on Fort Bliss’ McGregor Range in southern Otero County, New Mexico. The project was funded with a $5,000,000 grant to El Paso County from the U.S. Department of Energy (DOE) as part of the American Recovery and Reinvestment Act of 2009 and a $4,812,500 match provided by private sector partners. The project was administered through the DOE Golden Field Office to awardee El Paso County. The primary subcontractor to El Paso County and project Principal Investigator - Ruby Mountain Inc. (RMI) of Salt Lake City, Utah - assembled the project team consisting of Evergreen Clean Energy Management (ECEM) of Provo, Utah, and the Energy & Geoscience Institute at the University of Utah (EGI) in Salt Lake City, UT to complete the final phases of the project. The project formally began in May of 2010 and consisted of two preliminary phases of data collection and evaluation which culminated in the identification of a drilling site for a Resource Confirmation Well on McGregor Range. Well RMI 56-5 was drilled May and June 2013 to a depth of 3,030 ft. below ground level. A string of slotted 7 inch casing was set in 8.75 inch hole on bottom fill at 3,017 ft. to complete the well. The well was drilled using a technique called flooded reverse circulation, which is most common in mineral exploration. This technique produced an exceptionally large and complete cuttings record. An exciting development at the conclusion of drilling was the suspected discovery of a formation that has proven to be of exceptionally high permeability in three desalinization wells six miles to the south. Following drilling and preliminary testing and analysis, the project team has determined that the McGregor Range thermal anomaly is large and can probably support development in the tens of megawatts.

  8. Der ‚caligarische Imperativ'. Schrift und Bild im Stummfilm

    Directory of Open Access Journals (Sweden)

    Ulrich Johannes Beil

    2009-12-01

    Full Text Available Against the background of the Ut-pictura-poesis-discussion and the crisis of language at the beginning of the twentieth century, the article shows that silent movies used to integrate letters and writing not only for the obligatory title cards, but also, in a wider sense, as so called 'inserts': notes, letters, telegrams, certificates, testaments, etc.. The article analyses movies such as Der Golem, wie er in die Welt kam (1920, Nosferatu (1922, Dr. Mabuse, der Spieler (1922, Das Wachsfigurenkabinett (1923/24 and above all Robert Wienes' Das Cabinet des Dr. Caligari (1920 as examples of a complex and multfaceted mode of relation between picture and writing in the German Cinema of the Republic of Weimar. The famous order You must become Caligari in Wienes' film can be read as a hybrid formula, mixing as well the hypnotic imperative, the rhetoric of persuasion, the language of commercials, combining different discursive energies (medical, political, psychological, economical of the time.

  9. Development of Fast, Background-Limited Transition-Edge Sensors for the Background-Limited Infrared/Sub-Millimetre Spectrograph (BLISS) for SPICA

    Science.gov (United States)

    Beyer, Andrew D.; Runyan, M. C.; Kenyon, M.; Echternach, P. M.; Chui, T.; Bumble, B.; Bradford, C. M.; Holmes, W. A.; Bock, J. J.

    2012-01-01

    We report experimental progress toward demonstrating background-limited arrays of membrane-isolated transition-edge sensors (TESs) for the Background Limited Infrared/Sub-mm Spectrograph (BLISS). BLISS is a space-borne instrument with grating spectrometers for wavelengths lambda = 35-435 microns and with R = lambda/(delta)lambda approx. 500. The goals for BLISS TESs are: noise equivalent power (NEP) = 5x10(exp -20) W/Hz(1/2) and response time t or = 135mK) and Mo/Cu proximitized bilayers, where T(sub c) is the thermistor transition temperature. We measured the Ir TES arrays in our 50mK adiabatic demagnetization refrigerator test system, which can measure up to eight 1x32 arrays simultaneously using a time-division multiplexer, as well as our single-pixel test system which can measure down to 15mK. In our previous Ir array measurements our best reported performance was NEP=2.5x10(exp -19) W/Hz(1/2) and tapprox.5ms for straight-beam TESs. In fact, we expected NEPapprox.1.5x10(exp -19)W/Hz(1/2) for meander beam TESs, but did not achieve this previously due to 1/f noise. Here, we detail improvements toward measuring the expected NEP and demonstrate NEP=(1.3+0.2)x10(exp -19)W/Hz(1/2) in our single-pixel test system and NEP=(1.6+0.3)x10(exp -19)W/Hz(1/2) in our array test system.

  10. Development of Fast, Background-Limited Transition-Edge Sensors for the Background-Limited Infrared/Sub-mm Spectrograph (BLISS) for SPICA

    Science.gov (United States)

    Beyer, Andrew D.; Runyan, M. C.; Kenyon, M.; Echternach, P. M .; Chui, T.; Bumble, B.; Bradford, C. M.; Holmes, W. A.; Bock, J. J.

    2012-01-01

    We report experimental progress toward demonstrating background-limited arrays of membrane-isolated transition-edge sensors (TESs) for the Background Limited Infrared/Sub-mm Spectrograph (BLISS). BLISS is a space-borne instrument with grating spectrometers for wavelengths lambda=35-435 micron and with R=lambda/delta lambda approximately equals 500. The goals for BLISS TESs are: noise equivalent power (NEP) = 5x10 (sup -20) W/Hz(exp 1/2) and response time tau = 135mK) and Mo/Cu proximitized bilayers, where T(sub c) is the thermistor transition temperature. We measured the Ir TES arrays in our 50mK adiabatic demagnetization refrigerator test system, which can measure up to eight 1x32 arrays simultaneously using a time-division multiplexer, as well as our single-pixel test system which can measure down to 15mK. In our previous Ir array measurements our best reported performance was NEP=2.5x10(exp -19) W/Hz(sub 1/2) and Tau approximately equals 5ms for straight-beam TESs. In fact, we expected NEP approximately equals 1.5x10(exp -19)?W/Hz(sup 1/2) for meander beam TESs, but did not achieve this previously due to 1/f noise. Here, we detail improvements toward measuring the expected NEP and demonstrate NEP=(1.3+0.2)x10 (sup -19)W/Hz(exp 1/2) in our single-pixel test system and NEP=(1.6+/-0.3)x10(sup -19)W/Hz(sup 1/2) in our array test system.

  11. Baby-Led Introduction to SolidS (BLISS) study: a randomised controlled trial of a baby-led approach to complementary feeding.

    Science.gov (United States)

    Daniels, Lisa; Heath, Anne-Louise M; Williams, Sheila M; Cameron, Sonya L; Fleming, Elizabeth A; Taylor, Barry J; Wheeler, Ben J; Gibson, Rosalind S; Taylor, Rachael W

    2015-11-12

    In 2002, the World Health Organization recommended that the age for starting complementary feeding should be changed from 4 to 6 months of age to 6 months. Although this change in age has generated substantial debate, surprisingly little attention has been paid to whether advice on how to introduce complementary foods should also be changed. It has been proposed that by 6 months of age most infants will have developed sufficient motor skills to be able to feed themselves rather than needing to be spoon-fed by an adult. This has the potential to predispose infants to better growth by fostering better energy self-regulation, however no randomised controlled trials have been conducted to determine the benefits and risks of such a "baby-led" approach to complementary feeding. This is of particular interest given the widespread use of "Baby-Led Weaning" by parents internationally. The Baby-Led Introduction to SolidS (BLISS) study aims to assess the efficacy and acceptability of a modified version of Baby-Led Weaning that has been altered to address potential concerns with iron status, choking and growth faltering. The BLISS study will recruit 200 families from Dunedin, New Zealand, who book into the region's only maternity hospital. Parents will be randomised into an intervention (BLISS) or control group for a 12-month intervention with further follow-up at 24 months of age. Both groups will receive the standard Well Child care provided to all parents in New Zealand. The intervention group will receive additional parent contacts (n = 8) for support and education on BLISS from before birth to 12 months of age. Outcomes of interest include body mass index at 12 months of age (primary outcome), energy self-regulation, iron and zinc intake and status, diet quality, choking, growth faltering and acceptability to parents. This study is expected to provide insight into the feasibility of a baby-led approach to complementary feeding and the extent to which this method of

  12. Field Demonstration of Aviation Turbine Fuel MIL-T-83133C, Grade JP-8 (NATO Code F-34), at Fort Bliss, TX

    Science.gov (United States)

    1992-09-01

    APO NY 09052 CDR US ARMY NATICK RD&E CTR DOD PROJ MGR, MOBILE ELECTRIC POWER ATTN: SATNC-US US ARMY TROOP SUPPORT COMMAND NATICK MA 01760-5020 ATUN ...US ARMY QUARTERMASTER SCHOOL ATUN : LOEA-PL (MR LeVAN) I ATTN: ATSM-CDM 1 NEW CUMBERLAND PA 17070 ATSM-PWD I FORT LEE VA 23801 PETROLEUM FIELD OFFICE...ARTILLERY CENTER US ARMY INFANTRY SCHOOL & FORT BLISS ATTN: ATSH-CD-MIS-M I ATUN : ATZC-ISL-PP 3 ATSH-CD-TSM-T 1 ATZC-ISL-MM 3 FORT BENNING GA 31905-5400

  13. High-Arctic climate conditions for the last 7000 years inferred from multi-proxy analysis of the Bliss Lake record, North Greenland

    DEFF Research Database (Denmark)

    Olsen, Jesper; Kjær, Kurt H.; Funder, Svend Visby

    2012-01-01

    , Peary Land, Greenland. The early Holocene (10 850–10 480 cal. a BP) is characterized by increased erosion and gradually more marine conditions. Full marine conditions developed from 10 480 cal. a BP until the lake was isolated at 7220 cal. a BP. From its marine isolation at 7220 cal. a BP Bliss Lake...... becomes a lacustrine environment. Evidence from geochemical proxies (δ13C and total organic carbon) suggests that warmer conditions prevailed between 7220 and 6500 cal. a BP, corresponding to the Holocene thermal maximum, and from 3300 until 910 cal. a BP. From 850 to 500 cal. a BP colder climate...

  14. Dialogue is bliss

    Directory of Open Access Journals (Sweden)

    Giancarlo Sturloni

    2008-03-01

    Full Text Available The practice of dialogue does not erase the conflicts that can be found upon solid diverging interests. But conflicts are not forcedly a trauma. More then an impossible abolition of diversity, it is important to promote a practice that helps everybody to express their own point of view looking for socially sustainable solution between the parts. But according to Sturloni, «Even in that case: not a dialogue meant to achieve a utopian unitary view able to level all divergences, but to allow the expression of different perspectives and of legitimate interests. The final aim should be to make a choice shared as much as possible within the legal system of a democratic country».

  15. Ignorance is not bliss

    DEFF Research Database (Denmark)

    Jervelund, Signe Smith; Maltesen, Thomas; Wimmelmann, Camilla Lawaetz

    2017-01-01

    AIMS: Suboptimal healthcare utilisation and lower satisfaction with the patient-doctor encounter among immigrants has been documented. Immigrants' lack of familiarity with the healthcare system has been proposed as an explanation for this. This study investigated whether a systematic delivery...

  16. Nuclear: a blissful insecurity

    International Nuclear Information System (INIS)

    Moreau, A.

    2003-01-01

    The author used to work during more than 30 years at the Cea Saclay in the nuclear research. This book is an analysis of the anxieties generated by the Nuclear energy, the fundamental questions on our life style and the way that we give to our life. (A.L.B.)

  17. Comeniana aus dem Nachlass von Dietrich Mahnke. Die Korrespondenz zwischen Dietrich Mahnke und Dmitrij Tschižewskij aus dem Jahre 1935. Beilage: die Korrespondenz

    Czech Academy of Sciences Publication Activity Database

    Schifferová, Věra

    18/42/, - (2004), s. 219-223 ISSN 0231-5955 Institutional research plan: CEZ:AV0Z9009908 Keywords : The interpretation of Comenius * the pupils of Edmund Husserl * rationalism and mysticism Subject RIV: AA - Philosophy ; Religion

  18. Geologic and hydrologic data for the municipal solid waste landfill facility, U.S. Army Air Defense Artillery Center and Fort Bliss, El Paso County, Texas

    Science.gov (United States)

    Abeyta, Cynthia G.; Frenzel, P.F.

    1999-01-01

    Geologic and hydrologic data for the Municipal Solid Waste Landfill Facility on the U.S. Army Air Defense Artillery Center and Fort Bliss in El Paso County, Texas, were collected by the U.S. Geological Survey in cooperation with the U.S. Department of the Army. The 106.03-acre landfill has been in operation since January 1974. The landfill contains household refuse, Post solid wastes, bulky items, grass and tree trimmings from family housing, refuse from litter cans, construction debris, classified waste (dry), dead animals, asbestos, and empty oil cans. The depth of the filled areas is about 30 feet and the cover, consisting of locally derived material, is 2 to 3 feet thick. Geologic and hydrologic data were collected at or adjacent to the landfill during (1) drilling of 10 30- to 31-foot boreholes that were completed with gas-monitoring probes, (2) drilling of a 59-foot borehole, (3) drilling of a 355-foot borehole that was completed as a ground-water monitoring well, and (4) in situ measurements made on the landfill cover. After completion, the gas- monitoring probes were monitored on a quarterly basis (1 year total) for gases generated by the landfill. Water samples were collected from the ground-water monitoring well for chemical analysis. Data collection is divided into two elements: geologic data and hydrologic data. Geologic data include lithologic descriptions of cores and cuttings, geophysical logs, soil- gas and ambient-air analyses, and chemical analyses of soil. Hydrologic data include physical properties, total organic carbon, and pH of soil and sediment samples; soil-water chloride and soil-moisture analyses; physical properties of the landfill cover; measurements of depth to ground water; and ground-water chemical analyses. Interpretation of data is not included in this report.

  19. Geohydrologic site characterization of the municipal solid waste landfill facility, US Army Air Defense Artillery Center and Fort Bliss, El Paso County, Texas

    Science.gov (United States)

    Abeyta, Cynthia G.

    1996-01-01

    Geohydrologic conditions of the Municipal Solid Waste Landfill Facility (MSWLF) on the U.S. Army Air Defense Artillery Center and Fort Bliss, El Paso County, Texas, were evaluated by the U.S. Geological Survey in cooperation with the U.S. Army. The 106.03-acre MSWLF has been in operation since January 1974. The landfill contains household refuse, Post solid wastes, bulky items, grass and tree trimmings from family housing, refuse from litter cans, construction debris, classified waste (dry), dead animals, asbestos, and empty oil cans. The MSWLF, located about 1,200 feet east of the nearest occupied structure, is estimated to receive an average of approximately 56 tons of municipal solid waste per day and, at a fill rate of 1-4 acres per year, is expected to reach its capacity by the year 2004. The MSWLF is located in the Hueco Bolson, 4 miles east of the Franklin Mountains. Elevations at the MSWLF range from 3,907 to 3,937 feet above sea level. The climate at the MSWLF and vicinity is arid continental, characterized by an abundance of sunny days, high summer temperatures, relatively cool winters typical of arid areas, scanty rainfall, and very low humidity throughout the year. Average annual temperature near the MSWLF and vicinity is 63.3 degrees Fahrenheit and annual precipitation is 7.8 inches. Potential evaporation in the El Paso area was estimated to be 65 inches per year. Soils at and adjacent to the MSWLF are nearly level to gently sloping, have a fine sandy loam subsoil, and are moderately deep over caliche. The MSWLF is underlain by Hueco Bolson deposits of Tertiary age and typically are composed of unconsolidated to slightly consolidated interbedded sands, clay, silt, gravel, and caliche. Individual beds are not well defined and range in thickness from a fraction of an inch to about 100 feet. The primary source of ground water in the MSWLF area is in the deposits of the Hueco Bolson. A relatively thick vadose zone of approximately 300 feet overlies the

  20. Dialogue is bliss (Italian original version

    Directory of Open Access Journals (Sweden)

    Giancarlo Sturloni

    2008-03-01

    Full Text Available The practice of dialogue does not erase the conflicts that can be found upon solid diverging interests. But conflicts are not forcedly a trauma. More then an impossible abolition of diversity, it is important to promote a practice that helps everybody to express their own point of view looking for socially sustainable solution between the parts. But according to Sturloni, «Even in that case: not a dialogue meant to achieve a utopian unitary view able to level all divergences, but to allow the expression of different perspectives and of legitimate interests. The final aim should be to make a choice shared as much as possible within the legal system of a democratic country».

  1. Microgrid Enabled Distributed Energy Solutions (MEDES) - Fort Bliss Military Reservation

    Science.gov (United States)

    2014-04-01

    Security Act EPA Environmental Protection Agency EPAct05 Energy Policy Act of 2005 EPDF Enlisted Personnel Dining Facility EPEC El Paso Electric Company...Retrofitting the existing electrical infrastructure was a challenge, especially with the existing switchboard layout restricting the addition of motor ...operators (to allow for load shedding). The Lockheed Martin team installed as many motor operators as physically possible in the existing

  2. Fort Bliss Standards for the Treatment of Historic Buildings

    Science.gov (United States)

    2008-05-01

    rust and organic matter such as the tendrils left on the masonry after the removal of ivy. The construction of the building must be considered...flaking paint or moisture blisters on finished surfaces, • dank musty smells in high humid- ity or poorly ventilated areas, • rust and...ture is an integral part of the de NOTE: Remove only as much paint and rus will begin to rust again within a matter of h night. Thorough surface

  3. Indicator Accuracy and Monetary Policy: Is Ignorance Bliss?

    OpenAIRE

    Nimark, Kristoffer P.

    2003-01-01

    This paper argues that assuming a common information set shared by the public and the central bank may be inappropriate when one is concerned with the value of information itself. Specifically, we argue that it may lead one to draw the conclusion that monetary policy do not benefit from accurate real time data. This paper sets up a New-Keynesian model with optimal discretionary monetary policy, where we allow for partial and diverse information. The model is used to show that monetary policy ...

  4. Evaluation of Outcome of Models at Fort Bliss, Texas

    Science.gov (United States)

    1992-12-01

    15 Sex: M Age: 36 DOB: 5-13-55 Date of Injury: 8-2-91 Formal report received: 6-9-91 Injury: Shoulder strain, rotator cuff tear, and biceps tendon...right rotator cuff . COP: 2 days RTW: Returned to transitional work for two weeks, then to full duty. Job: mason Troop Clinic/WBAMC: All treatment was...flexor tendons of the right wrist; bilateral carpal tunnel syndrome; bilateral tendinitis . COP: 13 days RTW: Return to partial duty after COP. Reassigned

  5. Food allergy knowledge of parents - is ignorance bliss?

    NARCIS (Netherlands)

    Goossens, Nicole J.; Flokstra-de Blok, Bertine M. J.; van der Meulen, Gerbrich N.; Botjes, Erna; Burgerhof, Hans G. M.; Gupta, Ruchi S.; Springston, Elizabeth E.; Smith, Bridget; Duiverman, Eric J.; Dubois, Anthony E. J.

    Background: Food allergic children are at least partially dependent on their parents to care for their food allergy. In addition, parents are often responsible for the education of others regarding food allergy, including the family, school, neighbors, and friends. The aim of this study was to

  6. Comparative Demonstration and Evaluation of Classification Technologies: Closed Castner Range, Fort Bliss, Texas

    Science.gov (United States)

    2017-01-23

    reflecting the official policy or position of the Department of Defense. Reference herein to any specific commercial product, process, or service by...Former Camp Ellis Military Range (CEMR), which is a site known to contain evidence of 2.36-inch practice rockets , hand grenades, and rifle grenades

  7. Military Adjustment Units (MAU) Fort Bliss, Texas and Fort Jackson, South Carolina

    Science.gov (United States)

    1981-12-08

    for those not prepared for training. It allows the trainer, given proper guidance about deficiencies, to help fill in the gaps in knowledge ...Why You’re Needed", discuss with students the importance of "the role they play in the US Army, and how their efforts, abilities and knowledge can be...34Weari ng. of the Uniform", "Mirror, Mirror." DAY II - "Correctional Treatment", "Heritage of the Soldier." DAY III - "Tale of Two Skiers ." 22 APPENDIX

  8. Ignorance is not bliss: Statistical power is not probability of trial success.

    Science.gov (United States)

    Zierhut, M L; Bycott, P; Gibbs, M A; Smith, B P; Vicini, P

    2016-04-01

    The purpose of this commentary is to place probability of trial success, or assurance, in the context of decision making in drug development, and to illustrate its properties in an intuitive manner for the readers of Clinical Pharmacology and Therapeutics. The hope is that this will stimulate a dialog on how assurance should be incorporated into a quantitative decision approach for clinical development and trial design that uses all available information. © 2015 ASCPT.

  9. Anxious bliss: a case study of dissociation in a Mexican nun.

    Science.gov (United States)

    Lester, Rebecca J

    2008-03-01

    This is a case study of Celeste, postulant in a Roman Catholic convent in Mexico who experienced frequent episodes of leaving her body to commune with God. During these experiences, Celeste felt immersed in an ;incredibly beautiful profound silence' where ;time and space were broken.' But as much as Celeste craved these experiences, they also alarmed her; she was acutely aware that they might be indicative of psychological or neurological dysfunction. This article chronicles Celeste's struggles to make sense of her experiences in light of competing explanatory models. Her ultimate resolution suggests intriguing new directions for transcultural psychiatric research.

  10. Condition Assessment of William Beaumont General Hospital Historic Building at Fort Bliss, Texas

    Science.gov (United States)

    2002-09-01

    architectural programs and design con- cepts, cost analyses, design development, and finally rehabilitation or construction for adaptive reuse. CERL will...prevailing fire safety standards. The chapel’s interior is unique within an otherwise utilitarian architectural envi- ronment of the WBGHHD. While the... ecclesiastical casework will likely be removed, the elegance of the space, roof structure, and woodwork can be recaptured. The clear dimensions of the

  11. A Case Study: Business Process Reengineering at Raymond W. Bliss Army Community Hospital

    Science.gov (United States)

    1997-05-01

    Among the causes listed are: • Inadequate Management of Resistance • Attempting Painless Reengineering • Lack of Understanding About Reengineering...Parathyroid Proc. 0.9554 $5,458 1 0.9554 $5,458 SD 290 Thyroid Proc 0.9362 $5,349 3 2.8086 $16,046 SD 291 Thyroglossal Proc 0.4657 $2,661 2 0.9314 $5,321...Tissues Breast Age 0-17 0.6146 $2,799 SD 284 Minor skin disord. w/o CC 0.4042 $1,841 SD 289 Parathyroid Proc. 0.9554 $4,351 SD 290 Thyroid Proc

  12. Soil Survey Geographic (SSURGO) database for Fort Bliss Military Reservation, New Mexico and Texas

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This data set is a digital soil survey and generally is the most detailed level of soil geographic data developed by the National Cooperative Soil Survey. The...

  13. WW or WoW: the WW domains in a union of bliss.

    Science.gov (United States)

    Sudol, Marius; Recinos, Claudia C; Abraczinskas, Jennifer; Humbert, Jasper; Farooq, Amjad

    2005-12-01

    WW domains are small protein modules that recognize proline-rich peptide motifs or phosphorylated-serine/threonine proline sites in cognate proteins. Within host proteins these modules are joined to other protein domains or to a variety of catalytic domains acting together as adaptors or targeting anchors of enzymes. An important aspect of signaling by WW domains is their ability to recognize their cognate ligands in tandem. Tandem WW domains not only act in a synergistic manner but also appear to chaperone the function of each other. In this review, we focus on structure, function, and mechanism of the tandem WW domains co-operativity as well as independent actions. We emphasize here the implications of tandem arrangement and cooperative function of the domains for signaling pathways.

  14. 76 FR 65216 - Baby Bliss, Inc., Middleville, MI; Notice of Negative Determination Regarding Application for...

    Science.gov (United States)

    2011-10-20

    ... to the production of children's clothing. The petition (dated August 8, 2011) stated that ``Pleasant... February 2008, then incarcerated from February 2008 through March 2011. Pursuant to 29 CFR 90.18(c...

  15. When Ignorance is Bliss* : Information Asymmetries Enhance Prosocial Behavior in Dicator Games

    OpenAIRE

    Winschel, Evguenia; Zahn, Philipp

    2014-01-01

    In most laboratory experiments concerning prosocial behavior subjects are fully informed how their decision influences the payoff of other players. Outside the laboratory, however, individuals typically have to decide without such detailed knowledge. To asses the effect of information asymmetries on prosocial behavior, we conduct a laboratory experiment with a simple non-strategic interaction. A dictator has only limited knowledge about the benefits his prosocial action generates for a recipi...

  16. When Ignorance is Bliss - Information Asymmetries Enhance Prosocial Behavior in Dictator Games

    OpenAIRE

    Evguenia Winschel; Philipp Zahn

    2014-01-01

    In most laboratory experiments concerning prosocial behavior subjects are fully informed how their decision influences the payoff of other players. Outside the laboratory, however, individuals typically have to decide without such detailed knowledge. To assess the effect of information asymmetries on prosocial behavior, we conduct a laboratory experiment with a simple non-strategic interaction. A dictator has only limited knowledge about the benefits his prosocial action generates for a recip...

  17. The Efficacy of Social Media Technologies in Academia: A Pedagogical Bliss or Digital Fad?

    Science.gov (United States)

    Kivunja, Charles

    2015-01-01

    Efficacy of a teaching strategy technically refers to the ability of that strategy to produce a desired or intended learning outcomes. To date, there is little information on the efficacy of social media technologies in academia and it is likely to be some time before their effectiveness is proven. It is therefore legitimate to ask the question,…

  18. Ignorance Is Bliss, But for Whom? The Persistent Effect of Good Will on Cooperation

    Directory of Open Access Journals (Sweden)

    Mike Farjam

    2016-10-01

    Full Text Available Who benefits from the ignorance of others? We address this question from the point of view of a policy maker who can induce some ignorance into a system of agents competing for resources. Evolutionary game theory shows that when unconditional cooperators or ignorant agents compete with defectors in two-strategy settings, unconditional cooperators get exploited and are rendered extinct. In contrast, conditional cooperators, by utilizing some kind of reciprocity, are able to survive and sustain cooperation when competing with defectors. We study how cooperation thrives in a three-strategy setting where there are unconditional cooperators, conditional cooperators and defectors. By means of simulation on various kinds of graphs, we show that conditional cooperators benefit from the existence of unconditional cooperators in the majority of cases. However, in worlds that make cooperation hard to evolve, defectors benefit.

  19. Evaluation of Student Injuries at the Sergeants Major Course (SMC), Fort Bliss, Texas, August 2013-May 2014

    Science.gov (United States)

    2016-06-24

    William Beaumont Army Medical Center Department of Preventive Medicine under the Executive Wellness Program. The Executive Wellness Program consists...Fields KB. 2011. Running injuries – changing trends and demographics. Curr Sports Med Rep 10(5): 299-303. Franche, RL, Cullen K, Clarke J

  20. Soil-Geomorphic and Paleoclimatic Characteristics of the Fort Bliss Maneuver Areas, Southern New Mexico and Western Texas

    Science.gov (United States)

    1994-03-07

    intensity, isolated thunderstorms that can cause flash flooding (USDA 1981). Relative humidity ranges from 40 to 60 percent ( Medellin -Leal 1982). Winds...the Digital Mapping Laboratory at NMSU. The ground-penetrating capabilities of radar have been useful in studies as diverse as soil mapping projects...Supplement 5, p. 137-151. Mellett, J. 1990 Ground-penetrating Radar Enhances Knowledge of Earth’s Surface Layer. Geotimes, September 12-14. Medellin -Leal, F

  1. Ignorance is bliss. How parents of preschool children make sense of front-of-package visuals and claims on food.

    Science.gov (United States)

    Abrams, Katie M; Evans, Caitlin; Duff, Brittany R L

    2015-04-01

    With growing scrutiny over how the food industry advertises products aimed toward children and fewer consumers using nutrition facts panels and ingredient lists, the fronts of food packages have become an increasingly important marketing tool to understand. Front-of-package (FOP) visual and verbal claims play a critical role in capturing consumers' attention and helping them choose foods that fit their goals. Due to only possessing emergent literacy skills, preschool children are attuned to FOP visuals while parents are able to use the visuals in combination with verbal claims to make food choices for their children. The purpose of this focus group study was to explore how parents of preschool children make sense of FOP visual and verbal claims on packaged food products that are intended for their children. Thematic analysis revealed that parents associated aspects that most appeal to their preschool children - the characters and other playful visuals - with higher sugar content and artificial ingredients. However, parents were also easily led to believe the product was healthier based on visuals of fruit, more realistic pictures, health claims, cross-branding with healthier foods, and visuals suggesting the product is more natural. While parents recognized that the health claims and some visuals may not truly mean the food is healthier, they agreed that they rarely think beyond their initial impression. The food industry needs better regulatory guidance on how to communicate flavors and ingredients on package fronts in a way that helps consumers - particularly parents wanting to encourage healthy eating habits for their young children - better match their nutrition goals. Published by Elsevier Ltd.

  2. A Project to Develop a Marketing Plan in Support of William Beaumont Army Medical Center, Fort Bliss, Texas

    Science.gov (United States)

    1989-12-01

    stressed by the Texas Hospital Association (1982), "the key to success in applying and understanding the marketing mix lies in the concept of rightness...alternatives 8. Develop the marketing mix 9. Select a strategy option Phase III (Finalization)’ 10. Design the tactics 11. Present the plan 12. Write the plan...usage incentive Marketing mix Product, price, distribution [place], marketing communication [promotion] Contingency strategies Marketing Budget (How Much

  3. Demonstration of Advanced Geophysics and Classification Methods on Munitions Response Sites: Closed Castner Range Fort Bliss, TX

    Science.gov (United States)

    2016-04-01

    Basin has had a history of continuous, closed basin deposition, with Kansas playa complexes possibly united with Lake Cabeza de Vaca and/or Lake Lucero...Preparation Set up onsite project area Vegetation trimming Install blind seed items Labor Equipment rental Supplies Travel $74,499 TEMTADS Data...2,200 cued shots including re-collect, background, and IVS measurements) Project Geophysicist Equipment rental Supplies Travel $120,140 TEMTADS Data

  4. Terror and bliss? Commonalities and distinctions between sleep paralysis, lucid dreaming, and their associations with waking life experiences

    OpenAIRE

    Denis, Dan; Poerio, Giulia L.

    2016-01-01

    Summary Sleep paralysis and lucid dreaming are both dissociated experiences related to rapid eye movement (REM) sleep. Anecdotal evidence suggests that episodes of sleep paralysis and lucid dreaming are related but different experiences. In this study we test this claim systematically for the first time in an online survey with 1928 participants (age range: 18?82?years; 53% female). Confirming anecdotal evidence, sleep paralysis and lucid dreaming frequency were related positively and this as...

  5. Field Evaluation of All-Season Tactical Engine Oil OE/HDO-15/40 at Ft. Knox, Kentucky and Ft. Bliss, Texas

    Science.gov (United States)

    1986-07-01

    AND 13 oF PION ) I-. 0.50s0 £38T OIL ASILnSS LA•OlATO•T DATA BIL-L-21040 or/mOo ISO -60 Glass OIL fIiE IALIDATION PlOGI&l JAIOa•I-DIClI• E 1963 AND Jaiat...IGIl3 41013 , 3614. 6617, VII) TCODE*IBC25O 12S1 II0CIDIUI WAMIAiLI: 71 te0m Teal I stag SIO 0EW STD Isl33 mBIIUI AZINDOI VAIIAICES 1 Or Flog > I? 1980

  6. The BLISS cluster randomised controlled trial of the effect of 'active dissemination of information' on standards of care for premature babies in England (BEADI study protocol [ISRCTN89683698

    Directory of Open Access Journals (Sweden)

    Houston Rosie

    2007-10-01

    Full Text Available Abstract Background Gaps between research knowledge and practice have been consistently reported. Traditional ways of communicating information have limited impact on practice changes. Strategies to disseminate information need to be more interactive and based on techniques reported in systematic reviews of implementation of changes. There is a need for clarification as to which dissemination strategies work best to translate evidence into practice in neonatal units across England. The objective of this trial is to assess whether an innovative active strategy for the dissemination of neonatal research findings, recommendations, and national neonatal guidelines is more likely to lead to changes in policy and practice than the traditional (more passive forms of dissemination in England. Methods/design Cluster randomised controlled trial of all neonatal units in England (randomised by hospital, n = 182 and stratified by neonatal regional networks and neonatal units level of care to assess the relative effectiveness of active dissemination strategies on changes in local policies and practices. Participants will be mainly consultant lead clinicians in each unit. The intervention will be multifaceted using: audit and feedback; educational meetings for local staff (evidence-based lectures on selected topics, interactive workshop to examine current practice and draw up plans for change; and quality improvement and organisational changes methods. Policies and practice outcomes for the babies involved will be collected before and after the intervention. Outcomes will assess all premature babies born in England during a three month period for timing of surfactant administration at birth, temperature control at birth, and resuscitation team (qualification and numbers present at birth. Trial registration Current controlled trials ISRCTN89683698

  7. Spectral Demixing and Spectral Index Correlations for Subpixel Quantification of Land-Cover Components from Coarse Resolution Imagery at Fort Bliss, Texas

    Science.gov (United States)

    2003-12-01

    Application to Land-Cover Change in the Brazilian Amazon ,” Remote Sensing of Environment, vol 52, pp 137-154. Anderson, G.L., J.D. Hanson, and R.H. Haas...FORTRAN, Cambridge University Press. Price, K.P., D. A. Pyke,and L. Mendes. 1992. “Shrub Dieback in a Semiarid Ecosystem; The Integration of Remote

  8. Barriers and facilitators towards implementing the Sepsis Six care bundle (BLISS-1): a mixed methods investigation using the theoretical domains framework.

    Science.gov (United States)

    Roberts, Neil; Hooper, Guy; Lorencatto, Fabiana; Storr, Wendell; Spivey, Michael

    2017-09-19

    The 'Sepsis 6', a care bundle of basic, but vital, measures (e.g. intravenous fluid, antibiotics) has been implemented to improve sepsis treatment. However, uptake has been variable. Tools from behavioral sciences, such as the Theoretical Domains Framework (TDF) may be used to understand and address such implementation issues. This study used a behavioral science approach to identify barriers and facilitators towards Sepsis Six implementation at a case study hospital. Semi-structured interviews based on the TDF were conducted with a sample group of consultants, junior doctors and nurses from Emergency Department, Medical and Surgical Admissions, to explore barriers/facilitators to Sepsis Six performance. Transcripts were analyzed following the combined principles of content and framework analysis. Emerging themes informed a questionnaire to explore generalizability and importance across a sample of 261 stakeholders. Median importance and agreement ratings for each theme were calculated overall and for each role and clinical area. These were used to identify important barriers and important facilitators as targets for performance improvement. No new belief statements were discovered and data saturation was deemed achieved after 10 interviews. 1699 utterances were coded into 64 belief statements, then collated into a 51-item questionnaire. 113 questionnaire responses were obtained (44.3% response rate). Important barriers included insufficient audit and feedback, poor teamwork and communication, concerns about using the Sepsis Six in certain patients, insufficient training, and resource concerns. Facilitators included confidence in knowledge and skills, beliefs in overall benefits of the bundle, beliefs that identification and management of septic patients fell within everyone's role, and that regular use of the bundle made it easier to remember. Some beliefs were applicable for the entire group, others were specific to particular staff groups. A range of barriers and facilitators towards Sepsis Six performance across different staff groups were systematically identified using a theoretically-informed approach. This can inform development of targeted performance improvement interventions.

  9. T cell ignorance is bliss: T cells are not tolerized by Langerhans cells presenting human papillomavirus antigens in the absence of costimulation

    Directory of Open Access Journals (Sweden)

    Andrew W. Woodham

    2016-12-01

    Full Text Available Human papillomavirus type 16 (HPV16 infections are intra-epithelial, and thus, HPV16 is known to interact with Langerhans cells (LCs, the resident epithelial antigen-presenting cells (APCs. The current paradigm for APC-mediated induction of T cell anergy is through delivery of T cell receptor signals via peptides on MHC molecules (signal 1, but without costimulation (signal 2. We previously demonstrated that LCs exposed to HPV16 in vitro present HPV antigens to T cells without costimulation, but it remained uncertain if such T cells would remain ignorant, become anergic, or in the case of CD4+ T cells, differentiate into Tregs. Here we demonstrate that Tregs were not induced by LCs presenting only signal 1, and through a series of in vitro immunizations show that CD8+ T cells receiving signal 1+2 from LCs weeks after consistently receiving signal 1 are capable of robust effector functions. Importantly, this indicates that T cells are not tolerized but instead remain ignorant to HPV, and are activated given the proper signals. Keywords: T cell anergy, T cell ignorance, Immune tolerance, Human papillomavirus, HPV16, Langerhans cells

  10. Wilhelm Wundts Nachlass. Eine Übersicht.

    OpenAIRE

    Fahrenberg, Jochen

    2016-01-01

    Wilhelm Wundts Publikationen bilden wahrscheinlich das umfangreichste, zweifellos aber das vielseitigste Werk eines Psychologen. Auch sein wissenschaftlicher Nachlass an Manuskripten, Exzerpten und Korrespondenz hat einen ungewöhnlichen Umfang. Während es an guten Digitalisaten seiner Publikationen noch mangelt, ist der allergrößte Teil des Wundt-Nachlasses seit Ende 2015 dokumentiert und digitalisiert (Meyer, 2015). Die Übersicht hat 12 Abschnitte: (1) Wundts Publikationen, Bibliographie...

  11. Mexico’s Drug War and Its Unintended Regional Consequences

    Science.gov (United States)

    2013-03-01

    Guatemalan President Proposes Drug.” 26 Johnson, Forman, and Bliss , Police Reform in Latin America, 32, 28, 30. 27 Tim Johnson, “Society Has Lost...Nations Office on Drugs, Transnational Organized Crime, 76. 22 Stephen Johnson, Johanna Mendelson Forman and Katherine Bliss , Police Reform in...america (accessed October 29, 2012). 33 Johnson, Forman, and Bliss , Police Reform in Latin America, 22. 34 Hooper, "The Mexican Drug Cartel Threat

  12. Performance of the Defense Acquisition System, 2013 Annual Report

    Science.gov (United States)

    2013-06-28

    causes in the 18 analyses conducted by PARCA over the last 3 years (see Bliss , 2012a; Bliss , 2013). 34 Performance of the Defense Acquisition...assumptions (Arena et al., 2012; Bliss , 2012b). Framing assumptions are any explicit or implicit assumptions central in shaping cost, schedule, and...contracts starting after 1980 (n = 367) Cy cl e tim e in y ea rs All development contract cycle times increased significantly after 1980 59

  13. Operational Reservations: Considerations for a Total Army Force

    Science.gov (United States)

    2014-06-01

    individually proficient. To answer some of the questions about the viabil- ity of a 5-year training cycle for RC units, Major Gen- eral Tim Orr, the Adjutant...resident school). 85. “Structured Self-Development,” Ft. Bliss , TX: U.S. Army Sergeants Major Academy, available from https://usasma.bliss. army.mil

  14. Das Unsichtbare sichtbar machen. Zum vergessenen Beitrag der alten deutschen Frauenbewegung zur Wohn- und Siedlungsreform im frühen 20. Jahrhundert

    Directory of Open Access Journals (Sweden)

    Claudia Wucherpfennig

    2007-03-01

    Full Text Available Der Wohnungs- und Städtebau der Moderne gilt weitgehend als eine „Männerdomäne”. In ihrer Schrift Die Wohnungsfrage ist Frauensache! zeigen Ulla Terlinden und Susanna von Oertzen demgegenüber die vielfältigen und einflussreichen Beiträge der alten deutschen Frauenbewegung zur Wohnungsreform des frühen 20. Jahrhunderts und zum Neuen Bauen auf.

  15. United States Air Force Faculty Research Program 1989. Program Technical Report. Volume 4

    Science.gov (United States)

    1989-12-01

    Psychophysiology Systems, Processes and Applications, The Guilford Press, NY, pp. 354-377, 1986. Somsen, R., M. van der Molen , D. Boosma and J. Orlebeke. Phasic...June 1989. 5. Petri, C. A., "Kommiunikation mit Automaten," Schrifte des Rheinisch- Westfalischen Institutes fur instrumentelle Mathematik an der ...Psychophysiology of Cardiovascular Control. Orlebeke, J., G. Mulder and L. van Doornen (eds.), Plenum Press, NY, pp. 583-598, 1984. Wientjes, Kees. personal

  16. Potential application of remote sensing in monitoring informal settlements in developing countries where complimentary data does not exist

    CSIR Research Space (South Africa)

    Busgeeth, K

    2008-04-01

    Full Text Available Middle Class : Retreat Upper Middle Class : Terracotta Terraces Upper Middle Class : Dish and Decoder Set Upper Middle Class : Suburban Bliss Silver Spoons: Big Fish Silver Spoons: Fashion Cafe Society Silver Spoons: Cheese and Wine Silver Spoons...

  17. A Qualitative Study of Soldier Perceptions of the Relative Importance of MRE Portion Size and Variety

    National Research Council Canada - National Science Library

    Bell, R

    1999-01-01

    .... Bliss, Biggs Army Airfield, and Fort Leonard Wood during 1997 to understand how soldiers perceive Meal, Ready-to-Eat portion size and MRE variety and to begin to determine what types of trade offs...

  18. ECOTONE Manual

    National Research Council Canada - National Science Library

    Hochstrasser, Tamara; Peters, Debra

    2005-01-01

    .... One tool, the ECOTONE model, was set up to simulate vegetation recovery from military disturbances on Fort Bliss, Texas, as a conceptual structure to prioritize the research efforts in land management...

  19. Nauding kehale ja meelele / Marika Aret ; tekst Inna Inanna

    Index Scriptorium Estoniae

    Aret, Marika

    2014-01-01

    Mustamäel Mustamäe tee 17 avatud Bliss majast, kus muude teenuste kõrval pakutakse buffeeerestoranis ja kohvikus taime- ja toortoitu. Intervjuu Blissi käivitustiimi ja restorani perenaise Marika Aretiga

  20. 77 FR 66181 - Procurement List; Additions

    Science.gov (United States)

    2012-11-02

    ... Mile Marker, Winterhaven, CA. NPA: ARC-Imperial Valley, El Centro, CA Contracting Activity: Dept of..., DC Service Type/Location: Hospital Housekeeping, Raymond W. Bliss Army Health Center, 2240 E Winrow...

  1. Strategy-Policy Mismatch: How the U.S. Army Can Help Close Gaps in Countering Weapons of Mass Destruction

    Science.gov (United States)

    2014-01-01

    and Colonel Todd Key (G-35), MG John Rossi and Mr. Tim Muchmore (G-8/QDRO), Colonel Brad Gericke (Chief of Staff Coordina- tion Group), and LTG (ret...2006; and UNMOVIC, 2007. 2 32d AAMDC, Operation Iraqi Freedom Theater Air and Missile Defense History, Fort Bliss , Texas, September 2003. 3 T...Operation Iraqi Freedom Theater Air and Missile Defense History, Fort Bliss , Texas, September 2003. Abdelaziz, Salma, and Jim Sciutto, “OPCW: Only 11% of

  2. Defense AT and L. Volume 42, Number 1

    Science.gov (United States)

    2013-02-01

    Mike Kotzian, Duane Mallicoat, Tim Simpson, and Robert Landry Item-unique identification marks can be used to more efficiently manage inventory in...Evaluations themselves are conducted every 6 months at Fort Bliss , Texas, and White Sands Missile Range, N.M., they rely on a constant churn of activity in...hardware and software in close proximity, the lab is a more cost-effective environment to isolate and fix a problem than Fort Bliss and White Sands. The

  3. Daylight Redirecting Window Films

    Science.gov (United States)

    2013-09-01

    28 4.1.3 Fort Bliss , TX .......................................................................................29 4.1.4 Marine Corps Air Ground...Norfolk; Shawn Bogdan, Matt Siler and Kyle Hess at Naval War College, Newport; Marisela Leyva at Fort Bliss , TX; Clovis Vaughn and Andrew Burton at...team at Heschong Mahone Group (now part of TRC Companies): Lisa Heschong, Abhijeet Pande, Mudit Agarwal and Tim Perry for their immense contribution

  4. Improving the Efficacy of Department of the Army Title 10 Forces Performing Defense Support of Civil Authorities

    Science.gov (United States)

    2013-06-13

    Standing Rules for the Use of Force ix TACON Tactical Control TF Task Force TIC Toxic Industrial Chemical TIM Toxic Industrial Material UCMJ...The sole maneuver entity under TF-Ops was the Military Police Battalion stationed at Fort Bliss , Texas. The MP battalion had a garrison requirement...at Fort Bliss having conflicting ideas of what the CCMRF requirements were. This resulted in multiple higher headquarters with differing

  5. Learning from Our Military History: The United States Army, Operation Iraqi Freedom, and the Potential for Operational Art and Thinking

    Science.gov (United States)

    2013-06-14

    relationships, etc. 63For a philosophical and academic argument against EBO/EBAO, see Tim Challans, “Tipping Sacred Cows: Moral Potential Through...Springer, Fort Bliss , TX, 3 March 2011; BC020, Interview; BG060, Battalion Commander, Interview by Mark Battjes, Fort Stewart, GA, 15 March 2011. A...Interview; BE060, Interview; BC020, Interview; BB020, Battalion Commander, Interview by Mark Battjes and Nathan Springer, Fort Bliss , TX, 2 March

  6. Musikerbriefe als Spiegel überregionaler Kulturbeziehungen in Mittel - und Osteuropa

    Directory of Open Access Journals (Sweden)

    Loos Helmut

    2002-01-01

    Full Text Available (nemački Traditionell ist die Musikgeschichtsschreibung nicht nur in Deutschland, sondern auch im östlichen Europa sehr stark nationalen Kriterien verpflichtet, und Musik wird vor allem als Nationalkultur verstanden. Dem gegenüber stehen viele Verflechtungen von Musikern, die in vergangenen Jahrhunderten häufig an vielen Orten Europas anwesend und tätig waren. Diese Verbindungen sind immer wieder einmal thematisiert, aber nur ansatzweise systematisch erforscht worden. Die überregionale Korrespondenz der Musiker im mittleren und östlichen Europa macht nicht nur europäische Verflechtungen sichtbar, sie liefert auch authentische Einschätzungen der Erfahrungen, die an verschiedenen Orten gesammelt wurden. Insgesamt ist zu erwarten, daß Europa im Spiegel der Musikerbriefe als der zusammenhängende Kulturraum im Musikleben erscheint, als der er bis weit ins 20. Jahrhundert hinein existierte.

  7. Composting of biological waste. Processes and utilisation; Bioabfallkompostierung. Verfahren und Verwertung

    Energy Technology Data Exchange (ETDEWEB)

    Gronauer, A.; Claassen, N.; Ebertseder, T.; Fischer, P.; Gutser, R.; Helm, M.; Popp, L.; Schoen, H.

    1997-12-31

    The project investigated environmentally compatible concepts for procesing and utilisation of biological waste by means of composting and spreading on agricultural and gardening plots. The project comprised three parts: Composting techniques, applications of compost in agriculture and gardening, and applications in landscaping. This volume comprises all three reports. (orig./SR) [Deutsch] Die umweltschonende Aufbereitung und Verwertung von Bioabfall durch Kompostierung und Rueckfuehrung auf landwirtschaftliche und gaertnerische Flaechen wurde untersucht. Dieses Projekt war dreigeteilt in die Bereiche der Kompostierung selbst, der Anwendung des Komposts in der Landwirtschaft und seiner Anwendung im Gartenbau sowie im Garten- und Landschaftsbau (GaLa-Bau). Die vorliegende Schrift enthaelt die genannten drei Teilberichte. (orig./SR)

  8. Optimization of environment compatible analysis methods for mineral hydrocarbons in the soil; Optimierung umweltvertraeglicher Analysenverfahren fuer Mineraloelkohlenwasserstoffe im Boden

    Energy Technology Data Exchange (ETDEWEB)

    Flachowsky, J.; Borsdorf, H. [eds.] [UFZ - Umweltforschungszentrum Leipzig-Halle GmbH, Leipzig (Germany); Loehmannsroeben, H.G.; Roch, T. [Erlangen-Nuernberg Univ., Erlangen (Germany); Leopom, P. [Umweltbundesamt, Berlin (Germany); Reimers, C. [Technische Univ. Hamburg-Harburg, Hamburg (Germany); Matz, G.; Kuebler, J. [MOBILAB GmbH, Hamburg (Germany); Christall, B. [SOFIA GmbH, Berlin (Germany); Hahn, M.; Matschiner, H. [Elektrochemie Halle GmbH (Germany); Baermann, A. [Dr. Baermann und Partner Mikroanalytik, Hamburg (Germany)

    1997-12-31

    This paper describes several analytical methods for the quantitative chemical analysis of mineral oil hydrocarbons in soils. The measuring methods are investigated on accuracy, errors, sample preparation methods, analysis of reference materials and real materials. (SR) [Deutsch] Mit dieser Schrift praesentiert die Deutsche Bundesstiftung Umwelt der Oeffentlichkeit Ergebnisse zu alternativen umweltvertraeglichen Bestimmungsmethoden fuer Mineraloelkohlenwasserstoffe in Boeden. Es war in erster Linie das Ziel aller beteiligten Forscher und Entwickler, die heute noch in der Anwendung befindliche Vorschrift nach DIN 38409 H18 zur Analytik von Mineraloelkohlenwasserstoffen durch eine sowohl umweltfreundliche als auch insgesamt aussagekraeftige Methode zu substituieren. (orig.)

  9. Im Bild sprechen: Cixous Visual Instruction: Cixous

    OpenAIRE

    Jens E. Sennewald

    2006-01-01

    Gemeinsam von Künstlern und Wissenschaftlern/Philosophen erstellte Bücher sind selten und nicht immer erfolgreich. Eines der Fährnisse ist das Verhältnis zwischen bildlichen und schriftlichen Anteilen: Nicht selten wird der künstlerische Anteil zur Illustration der dominierenden Schrift. Eine Neupositionierung des Bildes im Buch ist nun der amerikanischen Künstlerin Roni Horn gelungen. Mehr als „sujet“ ihres Buches, ist die französische Philosophin Hélène Cixous gleichsam instruierende „Stimm...

  10. Entweder/Und, Wiederkunft/Erlösung

    OpenAIRE

    Löschenkohl, Birte

    2016-01-01

    Mit merklicher Begeisterung verfasst Walter Benjamin am 6. Januar 1938 einen Brief an Max Horkheimer, in dem er ihm von einem "seltnen Fund" von höchster Bedeutsamkeit berichtet, der seine Arbeit "entscheidend beeinflussen" werde (GB VI, 9). Bei dem Fund handelte es sich um Louis Auguste Blanquis (1805–1881) kosmologische Schrift 'L’Éternité par les astres', verfasst 1871 im Kerker einer Gefängnisburg vor der Küste der Bretagne. Der Autor, einer der umtriebigsten Revolutionäre Frankreichs im ...

  11. On US politics and IMF lending

    DEFF Research Database (Denmark)

    Andersen, Thomas Barnebeck; Harr, Thomas; Tarp, Finn

    2006-01-01

    The political factors shaping IMF lending to developing countries have attracted attention in recent empirical work. This goes in particular for the role and influence of the US. However, scant formal modelling makes interpretation of empirical results difficult. In this paper, we propose a model...... in which the US acts as principal within the IMF and seeks to maximize its impact on the policy stance of debtor countries. We derive an optimal loan allocation mechanism, which leads to the testable hypothesis that the probability of an IMF loan is increasing in the amount of political concessions...... countries make. A political concession is defined as the distance between a country's bliss point and its actual policy stance measured relative to the US. We introduce a bliss-point proxy and demonstrate that our hypothesis is strongly supported in the data. Moreover, we show that not accounting for bliss...

  12. Corrosion behavior of ion implanted nickel-titanium orthodontic wire in fluoride mouth rinse solutions.

    Science.gov (United States)

    Iijima, Masahiro; Yuasa, Toshihiro; Endo, Kazuhiko; Muguruma, Takeshi; Ohno, Hiroki; Mizoguchi, Itaru

    2010-01-01

    This study investigated the corrosion properties of ion implanted nickel-titanium wire (Neo Sentalloy Ionguard) in artificial saliva and fluoride mouth rinse solutions (Butler F Mouthrinse, Ora-Bliss). Non ion implanted nickel-titanium wire (Neo Sentalloy) was used as control. The anodic corrosion behavior was examined by potentiodynamic polarization measurement. The surfaces of the specimens were examined with SEM. The elemental depth profiles were characterized by XPS. Neo Sentalloy Ionguard in artificial saliva and Butler F Mouthrinse (500 ppm) had a lower current density than Neo Sentalloy. In addition, breakdown potential of Neo Sentalloy Ionguard in Ora-Bliss (900 ppm) was much higher than that of Neo Sentalloy although both wires had similar corrosion potential in Ora-Bliss (450 and 900 ppm). The XPS results for Neo Sentalloy Ionguard suggested that the layers consisted of TiO(2) and TiN were present on the surface and the layers may improve the corrosion properties.

  13. The Princeton colloquium

    CERN Document Server

    Bliss, Gilbert Ames

    1913-01-01

    Following the early tradition of the American Mathematical Society, the sixth colloquium of the Society was held as part of the summer meeting that took place at Princeton University. Two sets of lectures were presented: Fundamental Existence Theorems, by G. A. Bliss, and Geometric Aspects of Dynamics, by Edward Kasner. The goal of Bliss's Colloquium Lectures is an overview of contemporary existence theorems for solutions to ordinary or partial differential equations. The first part of the book, however, covers algebraic and analytic aspects of implicit functions. These become the primary too

  14. Exploring interaction between a non-speaking boy using aided AAC and his everyday communication partners: features of turn organizing and turn design

    DEFF Research Database (Denmark)

    Pilesjö, Maja Sigurd; Rasmussen, Gitte

    2011-01-01

    -at-action is suggested. The analyses demonstrate that the boy’s turn-at-actions are oriented to as a co-constructed and thus interactionally achieved unit: the boy points at a bliss symbol which is given voice by the speaking co-participant. In and through the relevant made voicing of the turn-at-action, a turn...... AAC, bliss symbolics. The analysis indicates that the participants can collaborately create and orient to units in interaction equivalent to turns in interaction although they differ dramatically from ordinary turns-at-talk. In order to capture the nature of the described units, the category turn...

  15. Performance of the Defense Acquisition System, 2015 Annual report

    Science.gov (United States)

    2015-09-16

    report was conducted by Dan Davis, Ken Munson, Susan L. Rose, and Philip S. Antón, with much-appreciated assistance from Larry Axtell, Gary R. Bliss ...primary writers, with very helpful reviews and comments provided by Philip D. Rodgers, Gary R. Bliss , Mildred Bonilla-Lucia, Michael E. Lebrun, and the...11 n/ a 20 12 n/ a 20 13 20 13 Un re al is tic p er fo rm an ce e xp ec ta tio ns 10 % 2 X X Un re al is tic b as el in e es tim at es fo r c os

  16. Daylight Redirecting Window Film

    Science.gov (United States)

    2013-12-01

    Fort Bliss , TX; Clovis Vaughn and Andrew Burton at 29 Palms, CA; Doug Taber at Naval Post Graduate School (NPS), Monterey; and Mitch Hailey at Naval...Agarwal and Tim Perry for their immense contribution to this project. Finally, throughout the project, the guidance and counseling of Vern Novstrup at...and control) VA Norfolk Z-133 1 1 1 6 72 48 120 CA 29 Palms 1416 5 7 14 13 108 31 62 RI Newport Hewitt Hall 2 5 9 19 88 24 40 TX Fort Bliss

  17. Backyard housing in Gauteng: an analysis of spatial dynamics

    CSIR Research Space (South Africa)

    Shapurjee, Y

    2014-05-01

    Full Text Available Crust 2M Pearl Strings 3M Cheese and Wine 4M Fashion Café Society 1T Big Fish NEW BONDS 15M Bond Battalions 16M Developer’s Dream 17M Strugglers Reward 7T Young Blues Town UPPER MIDDLE CLASS 5M Suburban Bliss 6M Dish and Decoder Set 7M Terracotta...

  18. Analysis of ecological context for identifying vegetation and animal conservation planning foci: An example from the arid South-western USA

    Science.gov (United States)

    Hamazaki, T.; Thompson, B.C.; Locke, B.A.; Boykin, K.G.

    2003-01-01

    In developing conservation strategies, it is important to maximize effects of conservation within a specified land tract and to maximize conservation effects on surrounding area (ecological context). The authors proposed two criteria to select biotic entities for conservation foci: (1) the relative occurrence of fauna or flora in a tract is greater than that of an ecological context region; and (2) occurrence of the fauna or flora is relatively limited in the ecological context region. Using extensive spatial data on vegetation and wildlife habitat distribution, the authors identified strategic vegetation and fauna conservation foci for the 400 000 ha Fort Bliss military reservation in New Mexico and Texas relative to a 164 km radius ecological context region intersecting seven ecological zones and the predicted habitat distribution of 616 animal species. The authors set two specific criteria: (1) predicted area of a species' occurrence is 5% (Fort Bliss is 4.2% of the region). These criteria selected one vegetation class and 40 animal species. Further, these vegetation and animal foci were primarily located in two areas of Fort Bliss. Sensitivity analyses with other analytical radii corroborated the context radius used. Conservation of the two areas and associated taxa will maximize the contribution of Fort Bliss's conservation efforts in its ecological proximity. This relatively simple but information-rich process represents economical and defensible preliminary contextual analysis for detailed conservation planning.

  19. Todorov, Levinas and anti-totalitarian humanism: A perspective on ...

    African Journals Online (AJOL)

    Interpretations of the utopian significance of his phenomenological notions such as death, time and sociality, Messianic hope, despair and moral repair are offered. It is emphasized that Levinas' early notion of innerworldly bliss constitutes a utopian core in his thought that is to be separate from the notion of innerworldly ...

  20. The Effects of Institutional Culture on Study Strategies of Hispanic Students as Measured by the "Inventario de Comportamiento de Estudio": The Spanish Version of the "Study Behavior Inventory."

    Science.gov (United States)

    Bliss, Leonard B.; Sandiford, Janice R.

    The study behaviors of Spanish-speaking students at a large two-year public college in the United States were studied using the Inventario de Comportamiento de Estudio (ECI) (L. Bliss, D. Vinay, and F. Koenigner), the Spanish version of the Learning and Study Strategies Inventory (C. Weinstein, 1987). Behaviors of these students were compared with…

  1. Narcotics-Fueled Violence in Mexico: Crisis for the United States?

    Science.gov (United States)

    2011-03-24

    cartels in Mexico which operate on a highly geographic basis. The DTOs responsible for the majority of violence in Mexico are the Tijuana, Gulf, Sinaloa ...infrastructure along the border region to deal with problems such as a mass migration . The Army maintains large facilities at Fort Bliss in El Paso, Texas and

  2. 77 FR 6548 - Environmental Impact Statement for the Implementation of Energy, Water, and Solid Waste...

    Science.gov (United States)

    2012-02-08

    ... development of existing wind energy resources on the eastern central and northern portions of Fort Bliss in New Mexico; and (7) the development of up to 20 MW of natural gas powered turbines as a complementary... migratory birds, soils and vegetation, noise impacts, increased traffic impacts, cultural resources, air...

  3. No impact of affective person knowledge on visual awareness : Evidence from binocular rivalry and continuous flash suppression

    NARCIS (Netherlands)

    Stein, T.; Grubb, C.; Bertrand, M.; Suh, S.M.; Verosky, S.C.

    2017-01-01

    Stimuli with intrinsic emotional value, like emotional faces, and stimuli associated with reward and punishment are often prioritized in visual awareness relative to neutral stimuli. Recently, Anderson, Siegel, Bliss-Moreau, and Barrett (2011) demonstrated that simply associating a face with

  4. A new strategy to enhance polysialic acid production by controlling ...

    African Journals Online (AJOL)

    STORAGESEVER

    2010-04-19

    Apr 19, 2010 ... derivatives, PSA is also used in control release of drugs. *Corresponding ... Camino et al., 1990; Rodriguez-Aparicio et al., 1988;. Rode et al. ..... 68: 132-153. Wunder DE, Aaronson W, Hayes SF, Bliss J, Silver RP (1994).

  5. Modern Electromagnetic Scattering

    Science.gov (United States)

    2013-08-10

    homeworks. The latter was an awesome preparation for the frustration that research brings, and the former turned sorrow into blissfulness ; • Dr...ra n ru n tim e 100 150 200 250 300 350 400 450 500 0 10 20 30 40 50 0 5 10 15 20 25 30 Figure 2.2: The ratio of total computational time required to

  6. Strategic Landpower and the Arabian Gulf

    Science.gov (United States)

    2013-01-01

    1st Armored Division, based in Fort Bliss , Texas, has been aligned with US Central Command and has played an important role in the Eager Lion...Trainers,” Washington Post, June 27, 2013. 46 Tim Ripley, Middle East Airpower in the 21st Century (South Yorkshire, UK: Pen and Sword, 2010), 173, 188

  7. Military Bases: Opportunities Exist to Improve Future Base Realignment and Closure Rounds

    Science.gov (United States)

    2013-03-01

    Operational Army—realigns Fort Bliss , TX; Fort Hood, TX; Fort Riley, KS; Fort Campbell, KY; and Fort Sill, OK to include rebasing of units from overseas to...Committee on Appropriations United States Senate The Honorable Tim Johnson Chairman The Honorable Mark Kirk Ranking Member Subcommittee on Military

  8. Bone Conduction Systems for Full-Face Respirators: Speech Intelligibility Analysis

    Science.gov (United States)

    2014-04-01

    acknowledge important technical assistance provided for the study by our ARL Human Research and Engineering Directorate (HRED) colleagues Tim ...RDRL HRM DE A MARES 1733 PLEASONTON RD BOX 3 FORT BLISS TX 79916-6816 NO. OF COPIES ORGANIZATION 30 8 ARMY RSCH LABORATORY

  9. U.S.-China Military Contacts: Issues for Congress

    Science.gov (United States)

    2013-07-25

    Washington, and New York. Despite the unofficial talks, PACOM Commander (Admiral Tim Keating), Chairman of the Joint Chiefs of Staff (Admiral Mike...led a delegation on military environmental protection matters to the United States. They visited Washington, DC; Fort Pickett in Virginia; Fort Bliss

  10. Preparing for the Future: The Regional Alignment of U.S. Army Brigade Combat Teams

    Science.gov (United States)

    2013-06-14

    the out of country Armor going to come from (Carson/ Bliss /Hood)? How long would it take it to get into theater in the middle of summer/winter? There...64. Arango, Tim . 2013. Attackers strike across Iraq as elections approach. The New York Times, 15 April. http://www.nytimes.com/2013/04/16/world

  11. Wounded Warrior Care and Reintegration Requires a Public-Private Partnership

    Science.gov (United States)

    2013-06-01

    Rep.) Tim Walz of Minnesota introduced a bill to Congress (along with cosponsors Rep. Walter B. Jones, North Carolina; Rep. Thomas Rooney, Florida...Campbell, Fort Bragg, Fort Bliss , Fort Hood, and Joint Base Lewis-McChord. The idea behind these clinics on the nation’s largest military installations

  12. Effects of Amplitude Compression on Relative Auditory Distance Perception

    Science.gov (United States)

    2013-10-01

    Laboratory for their support and a special thanks to Tim Mermagen for his efforts creating the computer program specifically for this project...MARES 1733 PLEASONTON RD BOX 3 FORT BLISS TX 79916-6816 NO. OF COPIES ORGANIZATION 8 ARMY RSCH LABORATORY – HRED (PDF

  13. Ultra-Sensitive Transition-Edge Sensors (TESs) for Far-IR/Submm Space-Borne Spectroscopy

    Science.gov (United States)

    Kenyon, M.; Day, P. K.; Bradford, C. M.; Bock, J .J.; Leduc, H. G.

    2011-01-01

    We have built surface micromachined thin-film metallized Si(x)N(y) optical absorbers for transition-edge sensors (TESs) suitable for the Background - Limited far-IR/Submm Spectrograph (BLISS). BLISS is a broadband (38 micrometers - 433 micrometers), grating spectrometer consisting of five wavebands each with a modest resolution of R (is) approx. 1000. Because BLISS requires the effective noise equivalent power (NEP) of the TES to be below 10 (exp 19) W/Hz(exp 1/2), our TESs consist of four long (1000 micrometers), narrow (0.4 micrometers ), and thin (0.25 micrometers ) Si(x) N(y) support beams that reduce the thermal conductance G between the substrate and the optical absorber. To reduce the heat capacity of the absorber and make the response time tau fast enough for BLISS, our absorbers are patterned into a mesh geometry with a fill factor of less than 10%. We use a bilayer of Ti/Au to make the effective impedance of the absorber match the impedance of the incoming radiation for each band. Measurements of the response time of the metallized absorbers to heat pulses show that their heat capacity exceeds the predictions of the Debye model. Our results are suggestive that the surface of the low pressure chemical vapor deposition (LPCVD) Si(x)N(y) used in the absorbers' construction is the source of microstates that dominate the heat capacity.

  14. Teaching communication aid use in everyday conversation

    DEFF Research Database (Denmark)

    Pilesjö, Maja Sigurd; Norén, Niklas

    2017-01-01

    This Conversation Analysis study investigated how a speech and language therapist (SLT) created opportunities for communication aid use in multiparty conversation. An SLT interacted with a child with multiple disabilities and her grandparents in a home setting, using a bliss board. The analyses...

  15. World And Woe: A Sociological Reading Of Proverbs As An ...

    African Journals Online (AJOL)

    Man, who inhabits the world of the living, has put in place various measures to guarantee a rewarding, stable, virile and blissful existence even as he interacts with the other elements that characterize his being. In spite of the conscious, concerted efforts man makes, unfolding realities portend, often times, various levels of ...

  16. Turning 'fate' into destiny by seizing a second chance at life

    African Journals Online (AJOL)

    2015-01-08

    Jan 8, 2015 ... under half the length of the train got to him, and he stifled agonised screams 'so as not to traumatise the families and little kids' alighting, blissfully unaware, above him. In hospital, whenever he regained any semblance of awareness, he feigned unconsciousness. A male nurse wheeling him on a gurney for.

  17. Das Unsichtbare sichtbar machen. Zum vergessenen Beitrag der alten deutschen Frauenbewegung zur Wohn- und Siedlungsreform im frühen 20. Jahrhundert Making the Invisible Visible—On a Forgotten Contribution to the Early German Women’s Movement: Housing Reform at the Beginning of the Twentieth Century

    Directory of Open Access Journals (Sweden)

    Claudia Wucherpfennig

    2007-03-01

    Full Text Available Der Wohnungs- und Städtebau der Moderne gilt weitgehend als eine „Männerdomäne”. In ihrer Schrift Die Wohnungsfrage ist Frauensache! zeigen Ulla Terlinden und Susanna von Oertzen demgegenüber die vielfältigen und einflussreichen Beiträge der alten deutschen Frauenbewegung zur Wohnungsreform des frühen 20. Jahrhunderts und zum Neuen Bauen auf.The building of apartments and cities in modernity is seen often as a “male domain.” In the text The Apartment Question is Women’s Work! (Die Wohungsfrage ist Frauensache!, Ulla Terlinden and Susanna von Oertzen present the multiple and influential contributions of the early German women’s movement to housing reform at the beginning of the twentieth century as well as to Neues Bauen, an architectural style of the 1920s.

  18. Hinkelbeinchen und "little chicken's leg": deutsche und amerikanische Idiome als kommunikative Textsorten-Problematik

    Directory of Open Access Journals (Sweden)

    Martin Wierschin

    1998-12-01

    Full Text Available Als Marin Luther 1522 seine Übersetzung des Neuen Testaments nach der griechischen Edition des Erasmus von Rotterdam abschloß, hatte er dabei zwar mit größtem Sprachgefühl nicht nur dem deutschen, sondem auch dem idiomatischen 'logos' des Griechischen "auf das Maul" gesehen. Aber er mußte in seinem "Sendbrief vom Dolmetschen" 1530 dennoch zugeben, daß selbst er - zusammen mit seinen beiden Assistenten Melanchthon und Aurogallus - sehr oft zwei bis vier Wochen lang nach einem einzigen idiomatisch treffenden Wort zu suchen hatte. Damit wird von einem eminenten Kronzeugen, nämlich vom Schöpfer des protestantischen 'Hausbuches' Lutherbibel und vom eigentlichen Begründer einer einheitlichen deutschen Schrift­ sprache, samt ihrer sprach- und literargeschichtlich wirkungsmächtigen Idiomatik, die Schwierigkeit und Problematik idiomatischer Äquivalenzen und Transferenzen zwischen den Einzelsprachen verbürgt.

  19. Composting of biological waste. Processes and utilisation. Summary report; Bioabfallkompostierung. Verfahren und Verwertung. Kurzfassung

    Energy Technology Data Exchange (ETDEWEB)

    Gronauer, A.; Claassen, N.; Ebertseder, T.; Fischer, P.; Gutser, R.; Helm, M.; Popp, L.; Schoen, H.

    1997-12-31

    The project investigated environmentally compatible concepts for processing and utilisation of biological waste by means of composting and spreading on agriculataural and gardening plots. The project comprised three parts: Composting techniques, applications of compost in agriculture and gardening, and applications in landscaping. This volume comprises the summaries of the three part-projects. (orig./SR) [Deutsch] Die umweltschonende Aufbereitung und Verwertung von Bioabfall durch Kompostierung und Rueckfuehrung auf landwirtschaftliche und gaertnerische Flaechen wurde untersucht. Dieses Projekt war dreigeteilt in die Bereiche der Kompostierung selbst, der Anwendung des Komposts in der Landwirtschaft und seiner Anwendung im Gartenbau sowie im Garten- und Landschaftsbau (GaLa-Bau). Die vorliegende Schrift enthaelt die Zusammenfassung der genannten drei Teilberichte. (orig./SR)

  20. Environmental offences in 1995. An evaluation of statistics; Umweltdelikte 1995. Eine Auswertung der Statistiken

    Energy Technology Data Exchange (ETDEWEB)

    Goertz, M.; Werner, J.; Sanchez de la Cerda, J.; Schwertfeger, C.; Winkler, K.

    1997-06-01

    This publication deals with the execution of environmental criminal law. On the basis of police and judicial statistics it is pointed out how often an environmental criminal offence was at least suspected by the police or law courts, how they reacted to their suspicion, which individual environmental criminal offences were committed particularly frequently, and what segment of the population the typical perpetrator belonged to. (orig./SR) [Deutsch] Mit der vorliegenden Schrift soll ein Blick auf den Vollzug des Umweltstrafrechts geworfen werden. Auf der Basis der Polizei- und Gerichtsstatistiken wird dargelegt, wie oft bei diesen Stellen mindestens der Verdacht einer Umweltstraftat bestand, wie auf diesen Verdacht reagiert wurde, welche einzelnen Umweltstraftaten besonders haeufig registriert wurden und aus welchem Personenkreis der tpische Taeter stammt. (orig./SR)

  1. Die Künstlerin als Arbeiterin (an der Gesellschaft. Lu Märtens zeitgemässe Betrachtungen zur Ökonomie der namenlosen Genialität The Woman Artist at Work. Lu Märten’s up-to-date Reflections on the Economy of the Nameless Genius

    Directory of Open Access Journals (Sweden)

    Verena Kuni

    2002-03-01

    Full Text Available In einem Reprint der Originalausgabe von 1919 endlich wieder zugänglich gemacht, empfiehlt sich Lu Märtens kleine Schrift Die Künstlerin nicht nur als Beitrag zur Vor- und Frühgeschichte der feministischen Kunstwissenschaft. Als historisch-kritische Analyse der Ökonomie künstlerischer Arbeit unter besonderer Berücksichtigung der Geschlechterdifferenz kann das Büchlein auch für aktuelle Debatten wichtige Denkanstösse liefern.Lu Märten’s essay, Die Künstlerin, now available as a reprint of the first edition published in 1919, is to be recommended not only as an important contribution to feminist art history avant la lettre. Moreover, the historical-critical analysis of the economy of artistic production which pays special attention to gender differences offers plenty of inspiration for current debates and reflections.

  2. Überleben & Überschreiten vs. Überlesen & Überschreiben. Die heteronormative Ordnung des queeren Diskurses

    Directory of Open Access Journals (Sweden)

    Dirk Schulz

    2012-11-01

    Full Text Available Sowohl im akademischen als auch im populären Gebrauch wird ›queer‹ infolge des fortwährenden Überschreibens und Überlesens bewusst ambivalenter Textgestaltungen schon seit einiger Zeit nicht mehr abgrenzend zu den häufig analog gebrauchten Termini gay/lesbian oder homosexual verstanden. Beispielhaft für diese Heteronormativierung ist der Umgang mit Oscar Wildes The Picture of Dorian Gray und Mrs. Dalloway von Virginia Woolf. Ihre genuin queere Verweigerung einer definierenden und kategorisierenden Denk- und Schreibweise findet bislang weder in der kritischen Rezeption noch in ihren Adaptionen der Milleniumswende ihre angemessene Korrespondenz. Im Gegenteil, das Beharren beider Erzählungen auf Uneindeutigkeit als Überlebensprinzip wird als ›Pose‹ bzw. ›Verschleierungstaktik‹ verstanden, wobei autobiographische Bezüge der Autor_innen vorherrschen. Auf diese Weise werden die subversiven Erzählstrategien beider Texte in eine heteronormative Ordnung überführbar.

  3. Modern Clinical Research on LSD

    OpenAIRE

    Liechti, Matthias E.

    2017-01-01

    All modern clinical studies using the classic hallucinogen lysergic acid diethylamide (LSD) in healthy subjects or patients in the last 25 years are reviewed herein. There were five recent studies in healthy participants and one in patients. In a controlled setting, LSD acutely induced bliss, audiovisual synesthesia, altered meaning of perceptions, derealization, depersonalization, and mystical experiences. These subjective effects of LSD were mediated by the 5-HT2A receptor. LSD increased fe...

  4. The QUELCE Method: Using Change Drivers to Estimate Program Costs

    Science.gov (United States)

    2016-08-01

    Analysis 4 2.4 Assign Conditional Probabilities 5 2.5 Apply Uncertainty to Cost Formula Inputs for Scenarios 5 2.6 Perform Monte Carlo Simulation to...Distribution Statement A: Approved for Public Release; Distribution is Unlimited 1 Introduction: The Cost Estimation Challenge Because large-scale programs... challenged [Bliss 2012]. Improvements in cost estimation that would make these assumptions more precise and reduce early lifecycle uncertainty can

  5. Spice, pot, and stroke.

    Science.gov (United States)

    Brust, John C M

    2013-12-10

    The endocannabinoid system includes 2 types of G-protein coupled receptors: CB1 (mostly in the brain) and CB2 (in peripheral lymphoid tissue). The major cannabinoid ligands are arachidonylethanolamine ("anandamide," the Sanskrit word for bliss) and 2-arachidonylglycerol ("2AG"). It is by binding to CB1 receptors that δ-9-tetrahydrocannabinol (THC), the principal psychoactive ingredient in marijuana ("pot"), produces its intended subjective effects.

  6. Risk Leading Indicators for DOD Acquisition Programs

    Science.gov (United States)

    2014-08-12

    Accomplishment 2: Preliminary Design Analysis. Criteria: Completed (a) design failure modes and effects analysis (DFMEA), (b) Fault Tree Analysis ( FTA ...Accomplishment 3, completed (a) updated DFMEA, (b) updated FTA , (c) updated reliability and maintainability estimates, (d) reliability growth plan and curve...Guide and Scheduling Guide (draft). GAO. Mar 2013. http://www.aacei-ncs.org/gaohq-6188401-v1- presentation_to_aace_mar-2013.pdf [5] Gary Bliss

  7. Strangers in a Strange Land: Envisioning the darker side of motherhood

    OpenAIRE

    Xeros-Constantinides, Sophia Strugnell

    2017-01-01

    Maternity is often idealized within society, where motherhood ‘myths’ paint unachievable pictures of maternal perfection and blissful union with baby. This thesis and studio-based artwork look behind the mask of maternal perfection, at what real women have said and shown of their actual experiences of maternity. The research examines the darker side of motherhood, and how this has been depicted. Through picture-making, I find new visual forms for maternity, based on the meta...

  8. Real-Time Identification of Wheel Terrain Interaction Models for Enhanced Autonomous Vehicle Mobility

    Science.gov (United States)

    2014-04-24

    tim at io n Er ro r ( cm ) 0 2 4 6 8 10 Color Statistics Angelova...Color_Statistics_Error) / Average_Slip_Error Position Estimation Error: Global Pose Po si tio n Es tim at io n Er ro r ( cm ) 0 2 4 6 8 10 12 Color...get some kind of clearance for releasing pose and odometry data) collected at the following sites – Taylor, Gascola, Somerset, Fort Bliss and

  9. How Much Will Be Enough? Assessing Changing Defense Strategies Implications for Army Resource Requirements

    Science.gov (United States)

    2014-01-01

    force management and modernization 59 See, for example, Tim Bonds, Glenn A. Kent, Colin Lampard, Randall Bowdish, John Birkler, Monti D. Callero... Tim , Glenn A. Kent, Colin Lampard, Randall Bowdish, John Birkler, Monti D. Callero, and James Chiesa, A Tool for Evaluating Force Modernization...Force Takes Shape at Fort Bliss ,” Army Magazine, Vol. 57, No. 3, March 2007. Harvey, Francis J., and Peter J. Schoomaker, 2007 Army Posture

  10. Medical Surveillance Monthly Report. olume 22, Number 1, January 2015

    Science.gov (United States)

    2015-01-01

    Bragg, NC . . 1 . . 1 2.3 Fort Bliss , TX . 1 . . . 1 2.3 Fort Hood, TX . . 1 . . 1 2.3 Joint base Langley-Eustis, VA 1 . . . . 1 2.3 Fort Lewis, WA...seasons in temperate climates but depends more on other factors aff ect- ing mosquito breeding such as the tim - ing of the rainy season and altitude (below

  11. The Impact of Divorce Among Marines, E-5 and Below, on Unit Operational Readiness

    Science.gov (United States)

    2013-04-12

    convinced that their relationship is already wonderful. They are equally assured that marriage will simply be a continuation of their present bliss ...Business Review, (November, 2007): 1-9. Call, Vaughn R. A. and Tim B. Heaton, “Religious Influence on Marital Stability,” Journal for the Scientific...bv.1355534169,d.dmQ&fp=facdc1ee60048919&bpcl=40096503 &biw=1024&bih=564. lxvi Vaughn R. A. Call and Tim B. Heaton, “Religious Influence on Marital

  12. GŁÓWNE NURTY W TEORII KAPITAŁU

    OpenAIRE

    Marchewka, Kamilla

    2000-01-01

    The history of capital theory has been of continuous debate. Many economists have tried to give any specific simple interpretation of capital and many of them failed. In literature we can find also a lot o f explanations of other definitions connected directly with the term o f capital - created sometimes in specific situations as particular theory. Keeping in mind the sentence written in 1975 by C. J. Bliss that „when economists reach agreement on the theory of capital they wi...

  13. Srovnání Platónova a Aristotelova pojetí etiky ctnosti

    OpenAIRE

    TISCHLEROVÁ, Monika

    2014-01-01

    This work deals with the comparison of Plato and Aristotle's conception of virtue ethics. The first part describes Plato's view of this area of philosophy. Plato puts his ethics based on the analogy between the municipality and the soul. Plato also operates with good ideas. In the second part, Aristotle view. First, I discuss the objectives of its philosophy, which is good, and then bliss. Then there is the division of the moral virtues and intellectual. Then describe each of Aristotle's virt...

  14. USSR Local War Doctrine as Rationale for the Development of the Soviet CTOL Aircraft Carrier.

    Science.gov (United States)

    1985-06-01

    Soviet Union. [Ref. 11: p. 252] The peacetime Red naval mission is not entirely one of blissful exchanges of pleasantries. Its utility during distant...expended toward gift presentation and the exchange of pleasantries. Such visits were designed as feelers to divine Russian acceptance by the developing...How- * ever, the presence of military forces displaying the capa- * bilities to intervene may have affected the perceptions of * Soviet clinets

  15. A Bayesian method for assessing multiscalespecies-habitat relationships

    Science.gov (United States)

    Stuber, Erica F.; Gruber, Lutz F.; Fontaine, Joseph J.

    2017-01-01

    ContextScientists face several theoretical and methodological challenges in appropriately describing fundamental wildlife-habitat relationships in models. The spatial scales of habitat relationships are often unknown, and are expected to follow a multi-scale hierarchy. Typical frequentist or information theoretic approaches often suffer under collinearity in multi-scale studies, fail to converge when models are complex or represent an intractable computational burden when candidate model sets are large.ObjectivesOur objective was to implement an automated, Bayesian method for inference on the spatial scales of habitat variables that best predict animal abundance.MethodsWe introduce Bayesian latent indicator scale selection (BLISS), a Bayesian method to select spatial scales of predictors using latent scale indicator variables that are estimated with reversible-jump Markov chain Monte Carlo sampling. BLISS does not suffer from collinearity, and substantially reduces computation time of studies. We present a simulation study to validate our method and apply our method to a case-study of land cover predictors for ring-necked pheasant (Phasianus colchicus) abundance in Nebraska, USA.ResultsOur method returns accurate descriptions of the explanatory power of multiple spatial scales, and unbiased and precise parameter estimates under commonly encountered data limitations including spatial scale autocorrelation, effect size, and sample size. BLISS outperforms commonly used model selection methods including stepwise and AIC, and reduces runtime by 90%.ConclusionsGiven the pervasiveness of scale-dependency in ecology, and the implications of mismatches between the scales of analyses and ecological processes, identifying the spatial scales over which species are integrating habitat information is an important step in understanding species-habitat relationships. BLISS is a widely applicable method for identifying important spatial scales, propagating scale uncertainty, and

  16. PERFORMANCE DETERIORATION OF THERMOSIPHON SOLAR FLAT PLATE WATER HEATER DUE TO SCALING

    OpenAIRE

    arunachala umesh chandavar

    2011-01-01

    The performance of Flat plate Solar Water Heater deteriorates within five to twelve years of their installation due to factors related to manufacturing, operating conditions, lack of maintenance etc. Especially, problem due to scaling is significant as it is based on quality of water used. The remaining factors are system dependent and could be overcome by quality production. Software is developed by incorporating Hottel Whillier Bliss (H-W-B) equation to ascertain the effect of scaling o...

  17. Concept and Canons of Fasting in Ayurveda

    OpenAIRE

    H Shripathi Adiga; Ramya S Adiga

    2013-01-01

    Ayurveda, manoeuvres mankind to head a healthy life in order to pursue four-fold bliss. With a view to combat physical and mental annoyances, classics have explicated two-fold therapeutic modalities; langhana/depletion and brihmana/nourishing. Upavasa /fasting is one among ten depletion therapies explained. It is envisioned at all three levels of Ayurvedic therapies- rational/objectively planned, psychological, and spiritual. Fasting is reckoned to be refraining from all forms of food intake ...

  18. Der Briefwechsel zwischen Karl Kreil und Alexander von Humboldt, ein wichtiger Beitrag zur Geschichte des Erdmagnetismus

    Directory of Open Access Journals (Sweden)

    Karin Reich

    2016-11-01

    Full Text Available Abstract The correspondence between Alexander von Humboldt und Karl Kreil was voluminous, it concerned earth magnetism. But only one letter has survived. This letter was written by Kreil on September 3, 1836; one day later Kreil wrote a letter to Carl Friedrich Gauss with nearly the same contents, some sentences are even literally corresponding. Four letters from Kreil to Humboldt were published in the „Annalen der Physik und Chemie“. Some letters were mentioned in the biographical literature dealing with Kreil. These letters show, that the correspondence covered at least the period until 1851 and give information about the intensive relationship between the two scientists. A further interesting source is the library of Humboldt which unfortunately has not survived. The catalogue mentions nine works of Kreil some of them where annotated by Humboldt. This makes it plausible that the contacts even lasted until 1856. Zusammenfassung Die Korrespondenz zwischen Alexander von Humboldt und Karl Kreil war umfangreich und betraf den Erdmagnetismus. Aber heute ist nur noch ein einziger Brief im Original bekannt. Dieser Brief, den Kreil am 3. September 1836 Alexander von Humboldt zukommen ließ, stimmt inhaltlich und teilweise wortwörtlich mit dem Brief überein, den Kreil nur einen Tag später, am 4. September 1836, an Carl Friedrich Gauß schickte. Vier Briefe von Kreil an Humboldt wurden in den „Annalen der Physik und Chemie“ publiziert, eine nicht allzu große Anzahl weiterer Briefe an Humboldt wurde in der biographischen Literatur über Kreil und in Briefen Kreils an Koller und Gauß erwähnt. Aber nicht nur die lückenhafte und bruchstückhaft bekannte Korrespondenz zwischen Humboldt und Kreil, die bis 1851 reicht, gibt Aufschluss über die Beziehungen, sondern von besonderer Bedeutung ist des Weiteren der Bestand an Kreiliana in der Bibliothek Humboldts. Es handelt sich um neun Werke Kreils, das letzte aus dem Jahr 1856. Nachweisbare

  19. Equivalence in Bilingual Lexicography: Criticism and Suggestions*

    Directory of Open Access Journals (Sweden)

    Herbert Ernst Wiegand

    2011-10-01

    , SYNTAGMENÄQUIVALENZ,NULLÄQUIVALENZ, KORRESPONDENZ

  20. Text as Locus, Inscription as Identity: On Barbara Honigmann's Roman von einem Kinde

    Directory of Open Access Journals (Sweden)

    Marilyn Sibley Fries

    1990-06-01

    Full Text Available Barbara Honigmann's Roman von einem Kinde (1986 constitutes the author's attempt at narrative self-definition. In this and other regards, it is similar to Christa Wolf's Kindheitsmuster (1976; Patterns of Childhood, 1980 , with which it is briefly compared. Honigmann's slim collection of stories, conceived by her as "sketches for self-portraits and landscapes," depicts the absolute isolation ofthe female Jewish narrator in the GDR and her search for community ( Heimat via language. Simultaneously, it records that narrator's desire to identify "places of transition," "boundaries at which conditions change" without fixing these in a static prison of text. The narrator-mother merges with the child born in the first story as, in the following ones, she comprehends the insignificance of her social (context, finally to simulate her own birth and the envied preverbal infant stage by means of self-expulsion—from the GDR via a "threefold salto mortale into the "Judaism of the Thora" in Strasbourg—into a "foreign language among foreign people." The narrator/author's position at a transitional boundary, underscored by the self-portrait that adorns the book's dust jacket, acknowledges the territory between two illegible texts and her reluctance to sacrifice "true reality" ( wahre Wirklichkeit by transforming "human being" into "text" ( Mensch into Schrift —a reluctance engendered by her meeting with Gershom Scholem in the central story of the volume.

  1. Truth, Art, and the “New Sensuousness”: Understanding Heidegger’s Metaphysical Reading of Nietzsche

    Directory of Open Access Journals (Sweden)

    James Magrini

    2009-06-01

    Full Text Available In the first of four lectures on Nietzsche’s philosophy, “The Will to Poweras Art” (1936-37, Heidegger argues that the unique and importantrelationship between truth and art, which Nietzsche suggests, must beunderstood “with a view to the conquest of nihilism,” i.e., within the historical context of a radically novel interpretation of sensuous reality. Beginning with the project of overturning Platonism as the active countermovement to nihilism, this essay interprets Heidegger’s difficult notion of the discordant relationship between truth (the fixation of semblance and art (the transfiguration of semblance in Nietzsche’s philosophy, emphasizing the supreme importance of art as life’s greatest enhancing force. The analysis is conducted within the context of Nietzsche’s metaphysics as presented by Heidegger, who claims thatas a metaphysical thinker, Nietzsche could not explain such topics as “truth,” “Being,” and “Becoming” in terms beyond the conceptualization of Western philosophy. In spite of that, his thought intimates a movement beyond the constraints of the tradition within which he was entrenched. In addition to providing a detailed exegesis of Heidegger’s lecture course, the problems associated with Heidegger’s metaphysical interpretation of Nietzsche’s philosophy will be discussed, problems that commentators such as Alan Schrift (Nietzsche and the Question of Interpretation believe stem from Heidegger’s stringent and restrictive methodological choices for approaching the reading of Nietzsche.

  2. Das Problem der Ethnogenese im antiken Griechenland

    Directory of Open Access Journals (Sweden)

    Welwei Karl-Wilhelm

    2011-01-01

    Full Text Available Sprachwissenschaftliche Untersuchungen lassen darauf schließen, dass die historischen Dialekte der alten Hellenen erst auf griechischem Boden um und nach 1000 v. Chr. entstanden sind. Bei den frühen Zuwanderern kann es sich nur um kleinere Verbände gehandelt haben, so daß zweifelllos keine großen „Stämme“ nach Griechenland vorgedrungen sind, wie man in der älteren Forschung angenommen hat. In Griechenland haben die Zuwanderer die Suffixe -ss und -nth oder -nd nicht erst kennengelernt, sondern zumindest zum Teil schon mitgebracht und vermutlich im 3. Jahrtausend v. Chr. die allmähliche Entwicklung des späteren Griechischen eingeleitet. Impulse für die Entwicklung der materiellen Kultur gingen um 1700 v. Chr. von Kreta aus und beeinflussten in starkem Maße die mykenische Zeit mit ihren Palastsystemen, deren Zusammenbruch um 1200 v. Chr. aber nicht schon zum Ende der mykenischen Kultur führte, wenn auch die Linear B-Schrift nicht mehr benutzt wurde und die Infrastrukturen der Machtzentren zusammenbrachen. Dies war zugleich die Voraussetzung für die Bildung kleinerer Siedlungen mit neuen Führungssystemen und Sozialstrukturen sowie mit einem jeweils eigenen Identitätsbewußtsein.

  3. Polilingvizmas kaip „grįžimas namõ“: tarp Babilono katastrofos ir Jeruzalės Sekminių stebuklo. Vlado Braziūno poezijos at(sivėrimai | Der Polylinguismus als „Rückkehr nach Hause“: zwischen der babylonischen Katastrophe und dem Pfingstwunder von Jerusalem

    Directory of Open Access Journals (Sweden)

    Skirmantas Valentas

    2006-01-01

    Full Text Available In diesem Beitrag wird ein Versuch unternommen, die Widerspiegelung von zwei philologisch wichtigen Episoden der Heiligen Schrift in der modernen Poesie zu vermitteln. Es geht um die Erzählung von der babylonischen Sprachenverwirrung im Buch der Anfänge und um das in den Apostelgeschichten erwähnte Pfingstwunder, die beide unter einen Begriff Polylinguismus fallen.Der Polylinguismus in der Poesie ist als eine syntagmatische Mehrsprachigkeit, anders gesagt, als eine implizite Benennung desgleichen Denotats in einigen Sprachen, zu betrachten.Der verallgemeinernde Begriff „Rückkehr nach Hause“ lässt zwei Begriffe in Verbindung setzen: die sich nach der babylonischen Katastrophe etablierte Mehrsprachigkeit und das Pfingstwunder als eine Möglichkeit die verwirrten Sprachen wieder zu einem Harmonischen zusammenzufügen.Da die Poesie als ein Grammatik modellierender Text vorliegt, ist eine Idee hervorzuheben, dass neben einer üblichen Sprache in der Poesie eine andere Sprache mit völlig anderen Regeln aufgedeckt werden muss.Als eines der Grundmerkmale der üblichen Sprache ist ein in ihr enthaltenes Oppositionsystem zu betrachten. Als Grundmerkmal einer anderen Sprache gilt dagegen das Schwinden der grundlegenden Oppositionen, das einen endlosen und periodischen Text schafft.Der Polylinguismus der Poesie wird in den linguistischen Geschichten am deutlichsten sichtbar. Der Polylinguismus in der Poesie, der dem Simultandolmetschen nahsteht, führt uns auf das Pfingstwunder zurück.

  4. Bacteriocin-like inhibitory activities of seven Lactobacillus delbrueckii subsp. bulgaricus strains against antibiotic susceptible and resistant Helicobacter pylori strains.

    Science.gov (United States)

    Boyanova, L; Gergova, G; Markovska, R; Yordanov, D; Mitov, I

    2017-12-01

    The aim of the study was to detect anti-Helicobacter pylori activity of seven Lactobacillus delbrueckii subsp. bulgaricus (GLB) strains by four cell-free supernatant (CFS) types. Activity of non-neutralized and non-heat-treated (CFSs1), non-neutralized and heat-treated (CFSs2), pH neutralized, catalase-treated and non-heat-treated (CFSs3), or neutralized, catalase- and heat-treated (CFSs4) CFSs against 18 H. pylori strains (11 of which with antibiotic resistance) was evaluated. All GLB strains produced bacteriocin-like inhibitory substances (BLISs), the neutralized CFSs of two GLB strains inhibited >81% of test strains and those of four GLB strains were active against >71% of antibiotic resistant strains. Two H. pylori strains were BLIS resistant. The heating did not reduce the CFS activity. Briefly, all GLB strains evaluated produced heat-stable BLISs, although GLB and H. pylori strain susceptibility patterns exhibited differences. Bacteriocin-like inhibitory substance activity can be an advantage for the probiotic choice for H. pylori infection control. In this study, anti-Helicobacter pylori activity of seven Lactobacillus delbrueckii subsp. bulgaricus (GLB) strains was evaluated by four cell-free supernatant (CFS) types. The GLB strains produced heat-stable bacteriocin-like inhibitory substances (BLISs) with a strong anti-H. pylori activity and some neutralized, catalase- and heat-treated CFSs inhibited >83% of the test strains. Bacteriocin-like inhibitory substance production of GLB strains can render them valuable probiotics in the control of H. pylori infection. © 2017 The Society for Applied Microbiology.

  5. The perfect man in the literary opus of John Climacus and Ibn Arabi

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    Rašić Dunja

    2015-01-01

    Full Text Available In search of the perfect man of the Islamic and Christian mysticisms, this paper also discusses the nature of mystical knowledge, to whose domain the perfect man, as the highest model of human existence and spiritual life, indisputably belongs. This study belongs to the philosophical discipline of comparative philosophy. Hence, searching for the lost paradise of human existence, still remembering the taste of bliss of residence filled only with infinite happiness, this paper will consider the extent to which the methodology of Paul Masson-Oursel and Henry Corbin, as two well-known comparative philosophy research methods can try to measure their strength with cryptic teachings of mysticism.

  6. SPICA sub-Kelvin cryogenic chains

    Science.gov (United States)

    Duband, L.; Duval, J. M.; Luchier, N.; Prouve, T.

    2012-04-01

    SPICA, a Japanese led mission, is part of the JAXA future science program and is planned for launch in 2018. SPICA will perform imaging and spectroscopic observations in the mid- and far-IR waveband, and is developing instrumentation spanning the 5-400 μm range. The SPICA payload features several candidate instruments, some of them requiring temperature down to 50 mK. This is currently the case for SAFARI, a core instrument developed by a European-based consortium, and BLISS proposed by CALTECH/JPL in the US. SPICA's distinctive feature is to actively cool its telescope to below 6 K. In addition, SPICA is a liquid cryogen free satellite and all the cooling will be provided by radiative cooling (L2 orbit) down to 30 K and by mechanical coolers for lower temperatures. The satellite will launch warm and slowly equilibrate to its operating temperatures once in orbit. This warm launch approach makes it possible to eliminate a large liquid cryogen tank and to use the mass saved to launch a large diameter telescope (3.2 m). This 4 K cooled telescope significantly reduces its own thermal radiation, offering superior sensitivity in the infrared region. The cryogenic system that enables this warm launch/cooled telescope concept is a key issue of the mission. This cryogenic chain features a number of cooling stages comprising passive radiators, Stirling coolers and several Joule Thomson loops, offering cooling powers at typically 20, 4.5, 2.5 and 1.7 K. The SAFARI and BLISS detectors require cooling to temperatures as low as 50 mK. The instrument coolers will be operated from these heat sinks. They are composed of a small demagnetization refrigerator (ADR) pre cooled by either a single or a double sorption cooler, respectively for SAFARI and BLISS. The BLISS cooler maintains continuous cooling at 300 mK and thus suppresses the thermal equilibrium time constant of the large focal plane. These hybrid architectures allow designing low weight coolers able to reach 50 mK. Because

  7. There is nothing paranormal about near-death experiences: how neuroscience can explain seeing bright lights, meeting the dead, or being convinced you are one of them.

    Science.gov (United States)

    Mobbs, Dean; Watt, Caroline

    2011-10-01

    Approximately 3% of Americans declare to have had a near-death experience. These experiences classically involve the feeling that one's soul has left the body, approaches a bright light and goes to another reality, where love and bliss are all encompassing. Contrary to popular belief, research suggests that there is nothing paranormal about these experiences. Instead, near-death experiences are the manifestation of normal brain function gone awry, during a traumatic, and sometimes harmless, event. Copyright © 2011 Elsevier Ltd. All rights reserved.

  8. Theory of synergistic effects: Hill-type response surfaces as 'null-interaction' models for mixtures.

    Science.gov (United States)

    Schindler, Michael

    2017-08-02

    The classification of effects caused by mixtures of agents as synergistic, antagonistic or additive depends critically on the reference model of 'null interaction'. Two main approaches are currently in use, the Additive Dose (ADM) or concentration addition (CA) and the Multiplicative Survival (MSM) or independent action (IA) models. We compare several response surface models to a newly developed Hill response surface, obtained by solving a logistic partial differential equation (PDE). Assuming that a mixture of chemicals with individual Hill-type dose-response curves can be described by an n-dimensional logistic function, Hill's differential equation for pure agents is replaced by a PDE for mixtures whose solution provides Hill surfaces as 'null-interaction' models and relies neither on Bliss independence or Loewe additivity nor uses Chou's unified general theory. An n-dimensional logistic PDE decribing the Hill-type response of n-component mixtures is solved. Appropriate boundary conditions ensure the correct asymptotic behaviour. Mathematica 11 (Wolfram, Mathematica Version 11.0, 2016) is used for the mathematics and graphics presented in this article. The Hill response surface ansatz can be applied to mixtures of compounds with arbitrary Hill parameters. Restrictions which are required when deriving analytical expressions for response surfaces from other principles, are unnecessary. Many approaches based on Loewe additivity turn out be special cases of the Hill approach whose increased flexibility permits a better description of 'null-effect' responses. Missing sham-compliance of Bliss IA, known as Colby's model in agrochemistry, leads to incompatibility with the Hill surface ansatz. Examples of binary and ternary mixtures illustrate the differences between the approaches. For Hill-slopes close to one and doses below the half-maximum effect doses MSM (Colby, Bliss, Finney, Abbott) predicts synergistic effects where the Hill model indicates 'null

  9. Effective Contracting: Trends and Lessons-Learned

    Science.gov (United States)

    2011-01-25

    Cell Locations: Current • Ft Bliss • Ft Hood • Ft Bragg • Ft Eustis • Ft Drum • Ft Knox • Korea • Ft Detrick • JTF- CAPMED Planned • Ft Carson...Huge culture shift – JTF- CAPMED , SAMMC, METC – Joint Basing (McCord-Lewis, Bragg-Pope, etc) – Europe, Pacific Rim  Expanding use of MATOs Contract...Support Services Better Acquisition Planning of Critical Health Care Products and Services will drive unwarranted variation and lower Per Capita Cost

  10. The Antiaircraft Journal. Volume 97, Number 4, July-August 1954

    Science.gov (United States)

    1954-08-01

    Col. Wood- row L. Nelson, Executive; Major Harry E. Bock, Jr., S2 and S3; Capt. Jesse N. Worsham, TI&E Officer; Lt. Bernard E. Reiter, Assistant S3; Lt...Major William J. Fling, S4, leaves for Hq. Fifth Army in July; Major Alfred H. Fierke, S2, for the 17th AAA Group; Major Bernard A. Gilman, for .USAR...USAFFE. {:onerly, U. E., to 758th FA Bn., Ft. Bragg. Cornwell , B. R., to AA&GM Qr., Ft. Bliss. Crews, D. J., to USAR Adv. Gp., Rock Islane, Illinois

  11. Sir Ronald A. Fisher and the International Biometric Society.

    Science.gov (United States)

    Billard, Lynne

    2014-06-01

    The year 2012 marks the 50th anniversary of the death of Sir Ronald A. Fisher, one of the two Fathers of Statistics and a Founder of the International Biometric Society (the "Society"). To celebrate the extraordinary genius of Fisher and the far-sighted vision of Fisher and Chester Bliss in organizing and promoting the formation of the Society, this article looks at the origins and growth of the Society, some of the key players and events, and especially the roles played by Fisher himself as the First President. A fresh look at Fisher, the man rather than the scientific genius is also presented. © 2014, The International Biometric Society.

  12. A Comparative Evaluation of the Thesaurus of Engineering and Scientific Terms and the DDC Retrieval and Indexing Terminology.

    Science.gov (United States)

    1977-11-01

    classificaLion schemes such as UDC, the Dewey Decimal Classification, Ranganathon’sColon Classifica- S tion, the Bliss Bibliographic Classification...UNLIMITED!IBIR-4J1 * : . C)" A COMPARATIVE EVALUATION OF THE THESAURUS OF, SAENGINEERING AND SCIENTIFIC TERMS AND THE DDC RETRIEVAL AND INDEXING...f cce7,i on For TER1 AND THE DDC RETRIEVAL AND A--" o " INDEXING TERMINOLOGY NTIS - * ByD , 2 _jDitr" : i :/ _ _ . _Av: "jl r " 1 t v Codes

  13. Howard Hughes and the Cold War Aviation Film Jet Pilot (1957

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    Richard Andrew Voeltz

    2016-10-01

    War.  But sexual intimacy, conspicuous consumption, and aviation technology also inserted themselves into the perfect safetly of American domestic bliss. This paper will analyze how the eccentric Cold War romantic comedy Jet Pilot (1957 so associated with the compulsiveness of Howard Hughes, produced and written by Jules Furthman, directed ( partially by Josef von Sternburg and starring John Wayne and Janet Leigh, reflects all these themes making it the paradigmatic Cold Film that remains a camp classic from the American popular cultyre of the 1950s.

  14. Ciclo de produção de cultivares de framboeseiras (Rubus idaeus submetidas à poda drástica nas condições do sul de Minas Gerais

    Directory of Open Access Journals (Sweden)

    Luana Aparecida Castilho Maro

    2012-06-01

    Full Text Available O presente trabalho teve como objetivo avaliar o ciclo de produção de cultivares de framboeseiras submetidas à poda drástica nas condições edafoclimáticas do sul de Minas Gerais. As cultivares escolhidas Batum, Autumn Bliss, Heritage e Golden Bliss foram avaliadas nas condições edafoclimáticas do sul de Minas Gerais desde a poda drástica até a produção e desenvolvimento de frutos nas hastes primárias e secundárias, e nas gemas subapicais. As hastes emitidas após a poda de inverno foram marcadas e avaliadas quanto ao início e término das fases de florescimento e frutificação. Para a determinação da curva de desenvolvimento dos frutos, foram feitas amostragens semanais desde o início da formação do fruto até a colheita. Conclui-se que ocorre a emissão de dois surtos de crescimento de rebentos oriundos do sistema radicular. As cultivares diferem quanto ao ciclo de produção nas hastes primárias e secundárias. As gemas subapicais mostram baixa capacidade de brotação e florescimento. Os frutos das diferentes cultivares apresentam padrão de crescimento sigmoidal simples.

  15. Authority in the service of morality: Miskawayh's analysis of social thought

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    Halilović Muamer

    2016-01-01

    Full Text Available Miskawayh was a philosopher of ethics, historian and statesman. He also had a great knowledge of Muslim sacred texts, the Quran and the Prophet's teachings. He was not simply randomly drawn to all these, though. Since in his early youth he served as an advisor to several Muslim viziers and rulers, he noted that the final bliss of mankind is guaranteed by social life, and that society is the fate of every person who wants overall prosperity, both spiritual and material. That is why he analyzed various models of achieving bliss in social life. As he was an Islamic thinker his attention was drawn to religion, but not exclusively within the frame of jurisprudence, although he considered it mandatory also. The focus of his social thought was on ethics, which he considered an integral part of religion. However, since he thought that realization of all ethical principles in society can be guaranteed only when power is in the hands of a just and legitimate political structure, he seriously engaged in an analysis of the essence of power and politics in society. On the other hand, in order to show successful and unsuccessful examples of implementation of proper political models in history, he looked in detail at almost all historical periods from the beginning of mankind until the moment he left public life. The history of Islamic social thought remembers him most for his attempt to link the ancient Greek views on ethics to the moral principles he found in Islam.

  16. Oral Candida in Patients with Fixed Orthodontic Appliance: In Vitro Combination Therapy.

    Science.gov (United States)

    Alhamadi, Wisam; Al-Saigh, Rafal J; Al-Dabagh, Nebras N; Al-Humadi, Hussam W

    2017-01-01

    Fixed orthodontic appliance (FOA) increases the cariogenic microorganisms of mouth including candida. The aim was to evaluate the pharmacodynamic effects of some antibacterial drugs in combination with most applicable antifungal agents on candida isolated from patients with FOA. Three antifungal agents (amphotericin B (AMB), ketoconazole (KET), and itraconazole (ITZ)) and three antibacterial drugs (ciprofloxacin (CIP), doxycycline (DOX), and metronidazole (MET)) with serial concentrations have been used and microdilution broth method has been done for single and combination therapy, then fungal growth was assessed spectrophotometrically, and the combinations were evaluated by bliss independent analysis. According to bliss independent interaction, the synergistic interactions depended on Δ E values that showed the best for CIP was with AMB (Δ E = 55.14) followed with KET (Δ E = 41.23) and lastly ITR (Δ E = 39.67) at CIP = 150 mg/L. DOX was optimal with KET (Δ E = 42.11) followed with AMB (Δ E = 40.77) and the lowest with ITR (Δ E = 9.12) at DOX = 75 mg/L. MET is the best with AMB (Δ E = 40.95) and then with ITR (Δ E = 35.45) and finally KET (Δ E = 15.15) at MET 200 mg/L. Moreover, usage of higher concentrations of antibacterial agents revealed inhibitory effects. This study uncovers the optimum antibiotic combination therapy against cariogenic candida with FOA by usage of low therapeutic concentrations.

  17. What is synergy? The Saariselkä agreement revisited.

    Science.gov (United States)

    Tang, Jing; Wennerberg, Krister; Aittokallio, Tero

    2015-01-01

    Many biological or chemical agents when combined interact with each other and produce a synergistic response that cannot be predicted based on the single agent responses alone. However, depending on the postulated null hypothesis of non-interaction, one may end up in different interpretations of synergy. Two popular reference models for null hypothesis include the Bliss independence model and the Loewe additivity model, each of which is formulated from different perspectives. During the last century, there has been an intensive debate on the suitability of these synergy models, both of which are theoretically justified and also in practice supported by different schools of scientists. More than 20 years ago, there was a community effort to make a consensus on the terminology one should use when claiming synergy. The agreement was formulated at a conference held in Saariselkä, Finland in 1992, stating that one should use the terms Bliss synergy or Loewe synergy to avoid ambiguity in the underlying models. We review the theoretical relationships between these models and argue that one should combine the advantages of both models to provide a more consistent definition of synergy and antagonism.

  18. Comparison of BiLinearly Interpolated Subpixel Sensitivity Mapping and Pixel-Level Decorrelation

    Science.gov (United States)

    Challener, Ryan C.; Harrington, Joseph; Cubillos, Patricio; Foster, Andrew S.; Deming, Drake; WASP Consortium

    2016-10-01

    Exoplanet eclipse signals are weaker than the systematics present in the Spitzer Space Telescope's Infrared Array Camera (IRAC), and thus the correction method can significantly impact a measurement. BiLinearly Interpolated Subpixel Sensitivity (BLISS) mapping calculates the sensitivity of the detector on a subpixel grid and corrects the photometry for any sensitivity variations. Pixel-Level Decorrelation (PLD) removes the sensitivity variations by considering the relative intensities of the pixels around the source. We applied both methods to WASP-29b, a Saturn-sized planet with a mass of 0.24 ± 0.02 Jupiter masses and a radius of 0.84 ± 0.06 Jupiter radii, which we observed during eclipse twice with the 3.6 µm and once with the 4.5 µm channels of IRAC aboard Spitzer in 2010 and 2011 (programs 60003 and 70084, respectively). We compared the results of BLISS and PLD, and comment on each method's ability to remove time-correlated noise. WASP-29b exhibits a strong detection at 3.6 µm and no detection at 4.5 µm. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

  19. Teste de modelos estatísticos para a estrutura a termo no Brasil

    Directory of Open Access Journals (Sweden)

    Gyorgy Varga

    2009-12-01

    Full Text Available São modelos adotados internacionalmente por praticantes e autoridades monetárias, mas pouco conhecidos na literatura local. Testamos os modelos com uma larga base de dados e todos eles indicaram problemas de especificação. Esse é um resultado semelhante ao obtido por Bliss (1997 para o mercado norte americano. A análise realizada também mostrou os limites na aplicação de diversos modelos de interpolação para construção da ET.We apply and test term structure fitting models like polynomial splines, flat forward and Nelson-Siegel to the Brazilian local term structure. They are models used all over the world by authorities and financial markets practitioners but less known locally. These models were tested with a large database with all of then presenting some specification problems. These results are similar to Bliss (1997 for US term structure and showed several limitations to the use of these models in the term structure fitting.

  20. Developing novel drugs for systemic lupus erythematosus. Lessons learned from the belimumab trials

    Directory of Open Access Journals (Sweden)

    Cristina Pamfil

    2012-07-01

    Full Text Available Systemic lupus erythematosus is the prototypic autoimmune disease with a broad range of clinical manifestations and a complex pathogenesis. B-cells hold a central role in its pathogenesis, not only as autoantibody producing cells, but also by producing other inflammatory mediators and by presenting autoantigens to autoreactive T cells. BlyS, a soluble ligand of the TNF cytokine family, is a key factor affecting B-cell homeostasis and survival and its blockade ameliorated the disease in animal models and preclinical studies of SLE. Following an unsuccessful phase II trial of belimumab, a monoclonal antibody targeting BlyS, two large phase III studies in patients with mild-to-moderate disease, BLISS-52 and BLISS-76, met their primary endpoints showing better efficacy of the drug over standard of care alone. To this end, development of a novel more sensitive responder index and improvements in study designs were crucial. As a result, belimumab became the first drug to get approval for the treatment of SLE after more than 50 years. In this paper we discuss the rationale, development, indications, lessons learned, pitfalls and challenges for this novel therapy and point-out to additional issues that need to be addressed in the future.http://dx.doi.org/10.7175/rhc.v3i3.206

  1. Discovering long-term potentiation (LTP) - recollections and reflections on what came after.

    Science.gov (United States)

    Lømo, T

    2018-02-01

    Chance events led me to a lifelong career in scientific research. They paved the way for being the first to see long-term potentiation of synaptic efficiency (LTP) in Per Andersen's laboratory in Oslo in 1966. Here I describe my way to this discovery and the experiments with Tim Bliss in 1968-1969 that led to Bliss and Lømo, 1973. Surprisingly, we later failed to reproduce these results. I discuss possible reasons for this failure, which made us both leave LTP research, in my case for good, in Tim's case for several years. After 30 years of work in a different field, I renewed my interest in the hippocampus and LTP in the early 2000s and published, for the first time, results that I had obtained 40 years earlier. Here I present my take on how interest in and research on LTP evolved after the early years. This includes a discussion of the functions of hippocampus as seen in those early days, the case of patient H.M., Donald Hebb's place in the story, the search for 'memory molecules' such as PKMζ, and the primary site for LTP expression (pre- and/or post-synaptic?). Throughout, I reflect on my life in science, how science is done and what drives it. The reflections are quite personal and I admit to mixed feelings about broadcasting them. © 2017 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.

  2. Progress on Background-Limited Membrane-Isolated TES Bolometers for Far-IR/Submillimeter Spectroscopy

    Science.gov (United States)

    Kenyon, M.; Day, P. K.; Bradford, C. M.; Bock, J. J.; Leduc, H. G.

    2006-01-01

    To determine the lowest attainable phonon noise equivalent power (NEP) for membrane-isolation bolometers, we fabricated and measured the thermal conductance of suspended Si3N4 beams with different geometries via a noise thermometry technique. We measured beam cross-sectional areas ranging from 0.35 x 0.5 (micro)m(sup 2) to 135 x 1.0 (micro)m(sup 2) and beam lengths ranging from (micro)m to 8300 (micro)m. The measurements directly imply that membrane-isolation bolometers are capable of reaching a phonon noise equivalent power (NEP) of 4 x 10(sup -20)W/Hz(sup 1)/O . This NEP adequate for the Background-Limited Infrared-Submillimeter Spectrograph (BLISS) proposed for the Japanese SPICA observatory, and adequate for NASA's SAFIR observatory, a 10-meter, 4 K telescope to be deployed at L2. Further, we measured the heat capacity of a suspended Si3N4 membrane and show how this result implies that one can make membrane-isolation bolometers with a response time which is fast enough for BLISS.

  3. Nuclear power - coal - climate. Demanding energy change; Kernkraft - Kohle - Klima. Energiewende nachgefragt

    Energy Technology Data Exchange (ETDEWEB)

    Krueger, Gustav

    2010-07-01

    The key to the survival of future generations is the availability of energy. This is the first publication ever to provide a current and comprehensive overview on current issues of German energy policy. The author concludes that the efficient handling of energy is necessary and correct, but this will not be enough by far to secure future energy supply. We will have to abandon the concept that these problems may be solved by wind power or solar power, as the book shows that these energy sources are not successful. Until advanced efficient technologies will arrive commercially on market, fossil fuels will be available in sufficient supply, but current energy policy strategies do not take account of this fact. The following issue derived from ''Energy - what everyone should know about it'' is enlarged by the chapter electromobility. (orig./GL) [German] Mit dieser Schrift liegt eine in wesentlichen Punkten erweiterte Neubearbeitung des Sachbuches Energie was jeder darueber wissen muss vor. Dr. Gustav Krueger gibt damit einen umfassenden Ueberblick ueber die aktuellen Fragen der Energiepolitik. Neu hinzugefuegt wurde das Kapitel Elektromobilitaet.Das Fazit des Autors: Sparsamer Umgang mit Energie ist notwendig und richtig, genuegt jedoch zur Sicherung des zukuenftigen Energiebedarfs bei weitem nicht.Krueger erlaeutert ausfuehrlich die Gruende, aus denen man sich schnellstmoeglich von der Vorstellung verabschieden sollte, energiepolitische Probleme seien schon heute mit Wind- und Solarkraft zu loesen. Es gibt zwar vielversprechende Ansaetze vom Aufwindkraftwerk bis hin zu Energie aus Algen und Wellenkraftwerken. Doch bis zur Marktreife neuer und effizienter Technologien muss auf fossile Energietraeger und Kernkraft zurueckgegriffen werden. (orig.)

  4. Droht den "kleinen Sprachen" das Aussterben?

    Directory of Open Access Journals (Sweden)

    Anita Lemić

    2014-12-01

    Full Text Available Die Prozesse der Globalisierung sind die Ursache für viele Änderungen in der Weltgemeinschaft, vor allem die Entfernung von Unterscheidungsmerkmalen (in Bezug darauf, dass „zwischen vielen ethnischen Zeichen, das was dauernd ist, ist die Dichotomisierung/Differenzierung eines „Wir-und-die-Anderen“ (Grbić, 2003, 93-64. Diese Zeichen wirken als Zeichen der Resozialisierung, die die bestehenden Identitäten löschen und sich an der Schaffung neuer Strukturen beteiligen. Die Zeit der Romantik in Europa ermöglichte die Schaffung von Nationalstaaten und ihr Hauptmerkmal war die Nationalsprache. Diese Art der sozialen Differenzierung hatte das Ziel, die Illusion einer vollständig homogenisierten Gesellschaft zu schaffen und damit den Prozess der Zerstörung der „kleinen“ Sprachen zu beginnen. Sprache und Kultur erwiesen sich als Grundlage der Gemeinschaftserhaltung. Die Homogenisierung ermöglicht Aktivitäten mit dem Ziel, einem Individuum zu helfen, sich als Individuum und als Mitglied der Gemeinschaft zu behaupten. Keine dieser beiden Identitäten kann ohne die Wechselwirkung mit der Umgebung erreicht werden. Die sprachliche Interaktion mit anderen Mitgliedern ist das Schlüsselsegment, das Menschen von anderen Lebensformen unterscheidet. Durch den Austausch von Erfahrungen mit anderen kommt der Mensch auf allen Ebenen voran und mit der Erfindung der Schrift öffnete er die Tür zur Entwicklung der Zivilisation. In dieser Arbeit beschäftigen wir uns mit der Frage der „Prestige“-Sprachen, die auf der Grundlage der Macht der Gemeinschaft der Muttersprachler ihren Bereich weit über die Grenzen des eigenen Landes hinaus erweitern und so eine politische und wirtschaftliche Vormachtstellung schaffen, aber auch mit den Auswirkungen jener Sprachen auf die Dekonstruktion oder möglicherweise vollständige Ausrottung der Sprachen, die auf diese Weise an Einfluss verlieren, unmodern werden und sich die Frage der Notwendigkeit ihrer

  5. History of Snake River Canyon Indicated by Revised Stratigraphy of Snake River Group Near Hagerman and King Hill, Idaho: With a Section on Paleomagnetism

    Science.gov (United States)

    Malde, Harold E.; Cox, Allan

    1971-01-01

    A discovery that debris left by the Bonneville Flood (Melon Gravel) overlies McKinney Basalt about 200 feet above the Snake River near King Hill requires that the stratigraphy of the Snake River Group be revised. In former usage, the McKinney Basalt and its immediately older companion, the Wendell Grade Basalt, were considered on the basis of equivocal field relations to be younger than the Melon Gravel and were assigned to the Recent. These lava flows are here reclassified as Pleistocene. The Bancroft Springs Basalt, which consists of both subaerial lava and pillow lava in a former Snake River canyon, was previously separated from the McKinney but is now combined with the McKinney. Accordingly, the name Bancroft Springs Basalt is here abandoned. This revised stratigraphy is first described from geomorphic relations of the McKinney Basalt near King Hill and is then discussed in the light of drainage changes caused by local lava flows during entrenchment of the Snake River. Near King Hill, a former Snake River canyon was completely filled by McKinney Basalt at the place called Bancroft Springs, hut the depth of this lava in the next several miles of the canyon downstream (along a route that approximately coincides with the present canyon) steadily decreased. This ancestral geomorphology is inferred from the former canyon route and, also, from the continuity in gradient of the McKinney lava surface downstream from Bancroft Springs. The drainage history recorded by various lava flows and river deposits of the Snake River Group indicates that the McKinney and Wendell Grade Basalts erupted after the Snake River canyon had reached its present depth of about 500 feet. The Snake River of that time, as far downstream as Bliss, flowed approximately along its present route. The Wood River of that time, however, skirted the north flank of Gooding Butte and joined the ancestral Snake at a junction, now concealed by lava, north of the present canyon about 3 miles west of Bliss

  6. Review of foreign approaches to development of communication in children with autistic spectrum disorders

    Directory of Open Access Journals (Sweden)

    Soldatenkova E.N.

    2015-03-01

    Full Text Available The article presents a generalized overview of international approaches to the evaluation and formation of communication in children with autism spectrum disor ders (ASD. Described radicals communication disorders in children with ASD. Analyzed foreign approaches (Communication system for the exchange of images (PECS Lori Frost and Andrew Bondy; options piktogramme6ideogrammic communication (bliss6symbolism, Loeb system, a system of sign language; Program in Applied verbal behavior; a Method of facilitating communication (FC and others used for the development of communication in children with ASD and donditions underlying these approaches. Examined differences in focus for the development of communication in children with ASD in domestic and foreign schools. The main conditions for the development of communication in children with ASD described in the framework of cultural historical psychology and activity approach, ensuring the inclusion of children with ASD in education.

  7. Honrosa visita

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    Revista Caldasia

    1943-08-01

    Full Text Available El 22 de abril visitaron el Instituto de Ciencias Naturales el Honorable Henry A. Wallace, Vicepresidente de los Estados Unidos de Norte América y el Excelentísimo señor doctor Alfonso López, Presidente de la Republica de Colombia, acompañados por S. E. el señor Arthur Bliss Lane, Embajador de los Estados Unidos en Bogotá, el doctor Rafael Parga Cortes, Ministro de la Educación Nacional, el doctor Julio Carrizosa Valenzuela, Rector de la Universidad Nacional, y otras personalidades muy distinguidas del cuerpo diplomático acreditado en Bogotá y de las esteras oficiales de nuestro país. / Cambio de Paginación de este Boletin.

  8. Dante o anjeloch (Dante on Angels

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    Jozef Žilinek

    2007-03-01

    Full Text Available Dante’s eternal Love was Bice Portinari who died in 1290. Dante saw her in Florence in 1274. She was his muse and her death was the reason to write Divine Comedy. We meet her in part of Divine Comedy calledParadise as a guide into Celestial Empire. I have ever been interested in structure of Celestial Empire and mesmerised by Dante. That was the reason to write this paper. I try to re-construct and complete Dante’s interpretation of the hierarchy of Celestial Empire with focusing on angels. Angels are also called Intellects or forms of the Heaven or substances between the Earth and Heaven or blissful Beings. I also try to find out the answer what happened to souls of people who died, especially to souls of innocent children. In memory of Michalka Režnáková (1984-1995.

  9. Which kind of mathematics was known by and referred to by those who wanted to integrate mathematics in «Wisdom» - Neopythagoreans and others?

    DEFF Research Database (Denmark)

    Høyrup, Jens

    Plato, so the story goes, held mathematics in high esteem, and those philosopher-kings that ought to rule his republic should have a thorough foundation in mathematics. This may well be true - but an observation made by Aristotle suggests that the mathematics which Plato intends is not the one...... based on theorems and proofs which we normally identify with "Greek mathematics". Most other ancient writers who speak of mathematics as a road towardWisdom also appear to be blissfully ignorant of the mathematics of Euclid, Archimedes, Apollonios, etc. The aim of the paper is to identify the kinds...... of mathematics which were available as external sources for this current (on the whole leaving out of consideration Liberal-Arts mathematics as not properly external). A number of borrowings can be traced to various practitioners' traditions - but always as bits borrowed out of context....

  10. Which kind of mathematics was known and referred to by those who wanted to integrate mathematics in «Wisdom»

    DEFF Research Database (Denmark)

    Høyrup, Jens

    2016-01-01

    Plato, so the story goes, held mathematics in high esteem, and those philosopher-kings that ought to rule his republic should have a thorough foundation in mathematics. This may well be true – but an observation made by Aristotle suggests that the mathematics which Plato intends is not the one...... based on theorems and proofs which we normally identify with “Greek mathematics”. Most other ancient writers who speak of mathematics as a road toward Wisdom also appear to be blissfully ignorant of the mathematics of Euclid, Archimedes, Apollonios, etc. – though not necessarily of their names. The aim...... of the paper is to identify the kinds of mathematics which were available as external sources for this current (on the whole leaving out of consideration Liberal-Arts mathematics as not properly external). A number of borrowings can be traced to various practitioners' traditions – but always as bits borrowed...

  11. Jesus and Afro-Pentecostal Prophets: Dynamics within the liminal space in Galilee and in Zimbabwe

    Directory of Open Access Journals (Sweden)

    Zorodzai Dube

    2015-07-01

    Full Text Available What happens when religious and spiritual interventions are used to explain concrete social economic reality? This study suggests that Afro-Pentecostal prophets in Zimbabwe exist within the liminal context; the prophets therefore function to redefine and contest identities in view of present social realities. This realisation allows for a comparison between the Zimbabwean prophets and Jesus of Nazareth, with a view to draw general conclusions regarding the function of prophets. As contribution, the study fills the void within the studies concerning the religious explanations of socioeconomic issues in view of structures of power. Borrowing from Herbert Marcuse, this study advances the thesis that the prophets attract people by miracles and promises of bliss and, in the process, divert people’s attention from directly confronting structures of power and hegemony.

  12. The discovery of long-term potentiation.

    Science.gov (United States)

    Lømo, Terje

    2003-04-29

    This paper describes circumstances around the discovery of long-term potentiation (LTP). In 1966, I had just begun independent work for the degree of Dr medicinae (PhD) in Per Andersen's laboratory in Oslo after an eighteen-month apprenticeship with him. Studying the effects of activating the perforant path to dentate granule cells in the hippocampus of anaesthetized rabbits, I observed that brief trains of stimuli resulted in increased efficiency of transmission at the perforant path-granule cell synapses that could last for hours. In 1968, Tim Bliss came to Per Andersen's laboratory to learn about the hippocampus and field potential recording for studies of possible memory mechanisms. The two of us then followed up my preliminary results from 1966 and did the experiments that resulted in a paper that is now properly considered to be the basic reference for the discovery of LTP.

  13. Scatological Images In Olympian 2

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    Glória Braga Onelley

    2014-12-01

    Full Text Available Based on the translation of the Greek text, we propose a reading of Pindar’s Olympian 2 ‑ epincian song in honor of the tyrant Theron of Acragas for his victory in the chariot during the 76th. Olympiad in 476. B.C. ‑ highlighting the representations of post‑mortem destiny. The ode the oldest literary text which states the belief in the distribution of rewards and punishments after death and alludes to the doctrine of reincarnation, with the promise of bliss in the hereafter for those who avoided the practice of injustice for three consecutive cycles of existence.http://dx.doi.org/10.14195/2183-1718_66_3

  14. Cows aboveground, protons down below

    CERN Multimedia

    Anaïs Schaeffer

    2011-01-01

    On display at Fort l'Écluse from 19 June to 18 September, the works of Augenblick combine photography, sound and video to create a striking instant parallel between the "real world" and the world of particle physics.   The cows are grazing quietly, blissfully unaware of the mini-Big Bang occurring silently 100 metres beneath them. Curious to compare these two worlds - the visible and the invisible, day-to-day life and particle physics - Laurent Mulot, a multi-disciplinary artist whose work delves into some of the planet's more unusual places, has come up with a unique artistic concept. Called Augenblick (German for "instant"), to emphasise that the images relate to the same point in time, his project uses photography, video and sound to superimpose scenes from everyday life and scenes from science. "The idea came to me in June 2008," says Laurent Mulot, "when Jean-Paul Martin, a research scientist at the Institute of Nuclear...

  15. A novel resveratrol-salinomycin combination sensitizes ER-positive breast cancer cells to apoptosis.

    Science.gov (United States)

    Venkatadri, Rajkumar; Iyer, Anand Krishnan V; Kaushik, Vivek; Azad, Neelam

    2017-08-01

    Resveratrol is a dietary compound that has been widely reported for its anticancer activities. However, successful extrapolation of its effects to pre-clinical studies is met with limited success due to inadequate bioavailability. We investigated the potential of combination therapy to improve the efficacy of resveratrol in a more physiologically relevant dose range. The effect of resveratrol on canonical Wnt signaling was evaluated by Western blotting. Wnt modulators HLY78 (activator) and salinomycin (inhibitor) were evaluated in combination with resveratrol for their effect on breast cancer cell viability (MTT assay), cell cycle progression and apoptosis (Western blotting). Bliss independency model was used to evaluate combinatorial effects of resveratrol-salinomycin combination. Resveratrol downregulated canonical Wnt signaling proteins in treated breast cancer cells (MCF-7, MDA-MB-231 and MDA-MB-468) in the dose range of 50-200μM, which also affected cellular viability. However, at very low doses (0-50μM), resveratrol exhibited no cellular toxicity. Co-treatment with salinomycin significantly potentiated the anti-cancer effects of resveratrol, whereas HLY78 co-treatment had minimal effect. Bliss independency model revealed that Wnt inhibition synergistically potentiates the effects of resveratrol in MCF-7 and BT474 cells. Significantly downregulated canonical Wnt signaling proteins and marker of epithelial-mesenchymal transition (EMT), vimentin were observed in cells treated with resveratrol-salinomycin combination. Cell cycle arrest, caspase activation and apoptosis induction in cells treated with resveratrol-salinomycin combination further confirmed the efficacy of the combination. We report a novel resveratrol-salinomycin combination for targeting ER-positive breast cancer cells and present evidence for successful pre-clinical implementation of resveratrol. Copyright © 2017 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban

  16. LSD Increases Primary Process Thinking via Serotonin 2A Receptor Activation

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    Rainer Kraehenmann

    2017-11-01

    Full Text Available Rationale: Stimulation of serotonin 2A (5-HT2A receptors by lysergic acid diethylamide (LSD and related compounds such as psilocybin has previously been shown to increase primary process thinking – an ontologically and evolutionary early, implicit, associative, and automatic mode of thinking which is typically occurring during altered states of consciousness such as dreaming. However, it is still largely unknown whether LSD induces primary process thinking under placebo-controlled, standardized experimental conditions and whether these effects are related to subjective experience and 5-HT2A receptor activation. Therefore, this study aimed to test the hypotheses that LSD increases primary process thinking and that primary process thinking depends on 5-HT2A receptor activation and is related to subjective drug effects.Methods: Twenty-five healthy subjects performed an audio-recorded mental imagery task 7 h after drug administration during three drug conditions: placebo, LSD (100 mcg orally and LSD together with the 5-HT2A receptor antagonist ketanserin (40 mg orally. The main outcome variable in this study was primary index (PI, a formal measure of primary process thinking in the imagery reports. State of consciousness was evaluated using the Altered State of Consciousness (5D-ASC rating scale.Results: LSD, compared with placebo, significantly increased primary index (p < 0.001, Bonferroni-corrected. The LSD-induced increase in primary index was positively correlated with LSD-induced disembodiment (p < 0.05, Bonferroni-corrected, and blissful state (p < 0.05, Bonferroni-corrected on the 5D-ASC. Both LSD-induced increases in primary index and changes in state of consciousness were fully blocked by ketanserin.Conclusion: LSD induces primary process thinking via activation of 5-HT2A receptors and in relation to disembodiment and blissful state. Primary process thinking appears to crucially organize inner experiences during both dreams and

  17. Le politique, opérateur de la construction des savoirs géographiques modernes: l'exemple des voyages d'Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Laura Péaud

    2011-10-01

    Full Text Available RésuméA la charnière du XVIIIème et du XIXème siècle, Alexander von Humboldt réalise une série de voyages scientifiques et géographiques en Europe, en Amérique et en Asie. Connus en grande partie par sa très riche correspondance, ces voyages sont tous marqués par la présence et l’intervention d’acteurs du monde politique européen. Par leur soutien financier, matériel et moral, ainsi que par leur délimitation spatiale, temporelle voire thématique des objets des expéditions, ceux-ci structurent pratiquement et intellectuellement le déroulement des expéditions humboldtiennes.Aux alentours du moment 1800, la géographie se trouve alors engagée dans un mouvement de construction disciplinaire, questionnant ses objets, ses méthodes et ses pratiques. Inséré dans ce processus, le voyage constitue un enjeu identitaire fort de l’élaboration et de la définition des savoirs géographiques modernes. La participation des acteurs politiques dans les voyages interroge leur rôle d’opérateurs de la fabrique scientifique. A partir de l’exemple humboldtien, dans une optique d’histoire et d’épistémologie de la géographie, cet article propose d’engager une analyse relationnelle du couple géographie/politique.ZusammenfassungZwischen 1799 und 1829 unternahm Alexander von Humboldt eine Reihe wissenschaftlicher Reisen durch Europa, Amerika und Asien. Nicht zuletzt dank der überlieferten Korrespondenz sind die Reisen sehr gut dokumentiert: Politische Akteure spielten eine große Rolle bei der Planung und Umsetzung der Reisen. So unterstützten sie Humboldts Reisen sowohl mit materiellen als auch ideellen Mitteln. Mitunter nahmen sie Einfluss auf Routen sowie auf Dauer und thematische Ausrichtung der Reisen. Dies strukturierte die Humboldt’schen Reisen intellektuell und in ihrer praktischen Umsetzung.Um 1800 bildete sich die Geographie zur wissenschaftlichen Disziplin heraus, ihre Forschungsgegenstände, Methoden und

  18. Health effects of ambient levels of respirable particulate matter (PM) on healthy, young-adult population

    Science.gov (United States)

    Shaughnessy, William J.; Venigalla, Mohan M.; Trump, David

    2015-12-01

    There is an absence of studies that define the relationship between ambient particulate matter (PM) levels and adverse health outcomes among the young and healthy adult sub-group. In this research, the relationship between exposures to ambient levels of PM in the 10 micron (PM10) and 2.5 micron (PM2.5) size fractions and health outcomes in members of the healthy, young-adult subgroup who are 18-39 years of age was examined. Active duty military personnel populations at three strategically selected military bases in the United States were used as a surrogate to the control group. Health outcome data, which consists of the number of diagnoses for each of nine International Classification of Diseases, 9th Revision (ICD-9) categories related to respiratory illness, were derived from outpatient visits at each of the three military bases. Data on ambient concentrations of particulate matter, specifically PM10 and PM2.5, were obtained for these sites. The health outcome data were correlated and regressed with the PM10 and PM2.5 data, and other air quality and weather-related data on a daily and weekly basis for the period 1998 to 2004. Results indicate that at Fort Bliss, which is a US Environmental Protection Agency designated non-attainment area for PM10, a statistically significant association exists between the weekly-averaged number of adverse health effects in the young and healthy adult population and the corresponding weekly-average ambient PM10 concentration. A least squares regression analysis was performed on the Fort Bliss data sets indicated that the health outcome data is related to several environmental parameters in addition to PM10. Overall, the analysis estimates a .6% increase in the weekly rate of emergency room visits for upper respiratory infections for every 10 μg/m3 increase in the weekly-averaged PM10 concentration above the mean. The findings support the development of policy and guidance opportunities that can be developed to mitigate exposures

  19. Fifty Shades: ambivalence about birth control in an erotic bestseller and its cultural implications.

    Science.gov (United States)

    Maierhofer, Waltraud; Israel, Emanuella

    2017-04-01

    The Fifty Shades trilogy by E.L. James has taken the world by storm and become a cultural phenomenon. The lack of contraceptive use in the erotic fiction, first pointed out by bloggers, is analysed in this article and compared to medical information. James may be praised for sexualising condom use. However, her protagonist makes poor choices in terms of hormonal contraception and is negligent about its use, resulting in an unintended pregnancy and resolved in marital bliss and motherhood. What is of more interest here than a possible message about contraceptive use, is the outcome that the fiction's negligence in birth control and responsibility affirms an ideology in which female sexuality and sexual experimentation can only be tolerated within the context of procreation and affirmation of motherhood. Subsequently, the cultural significance of the trilogy's popularity and its tension between sexual exploration, birth control and fertility is explored. In a globally popular fantasy published more than five decades after the introduction of the pill, the protagonist's lack of attention to reliable birth control leads to a telling dichotomy that combines adventurous exploration of female sexuality and affirmation of the nuclear family.

  20. Predicting prosodic structure by morphosyntactic category: A case study of Blackfoot

    Directory of Open Access Journals (Sweden)

    Joseph W. Windsor

    2017-02-01

    Full Text Available This study examines phonetic correlates to three prosodic categories in Blackfoot: the syllable (σ, the prosodic word (ω, and the phonological phrase (φ. I provide evidence that the Blackfoot σ is recognizable by an obligatory process of vowel coalescence and the φ is recognizable by an obligatory process of right edge aspiration. The ω can be distinguished from these other two prosodic constituents by an optional phonetic process which mimics intersyllabic vowel coalescence, but does not apply obligatorily. The prosodic categories investigated in this study are then correlated to three morphosyntactic categories: morphological agreement suffixes, lexical morphemes (adjectives and nouns, and demonstratives. This correlation is used to argue that morphological and syntactic processes function differently at the interface with phonology (cf. Russell 1999, ultimately raising questions with “word-internal syntax” analyses of Blackfoot suffixation which are derived through cyclic head movement (Bliss 2013; Wiltschko 2014 using the Mirror Principle (Baker 1985. This article is part of theSpecial Collection: Prosody and costituent structure

  1. Modern Clinical Research on LSD.

    Science.gov (United States)

    Liechti, Matthias E

    2017-10-01

    All modern clinical studies using the classic hallucinogen lysergic acid diethylamide (LSD) in healthy subjects or patients in the last 25 years are reviewed herein. There were five recent studies in healthy participants and one in patients. In a controlled setting, LSD acutely induced bliss, audiovisual synesthesia, altered meaning of perceptions, derealization, depersonalization, and mystical experiences. These subjective effects of LSD were mediated by the 5-HT 2A receptor. LSD increased feelings of closeness to others, openness, trust, and suggestibility. LSD impaired the recognition of sad and fearful faces, reduced left amygdala reactivity to fearful faces, and enhanced emotional empathy. LSD increased the emotional response to music and the meaning of music. LSD acutely produced deficits in sensorimotor gating, similar to observations in schizophrenia. LSD had weak autonomic stimulant effects and elevated plasma cortisol, prolactin, and oxytocin levels. Resting-state functional magnetic resonance studies showed that LSD acutely reduced the integrity of functional brain networks and increased connectivity between networks that normally are more dissociated. LSD increased functional thalamocortical connectivity and functional connectivity of the primary visual cortex with other brain areas. The latter effect was correlated with subjective hallucinations. LSD acutely induced global increases in brain entropy that were associated with greater trait openness 14 days later. In patients with anxiety associated with life-threatening disease, anxiety was reduced for 2 months after two doses of LSD. In medical settings, no complications of LSD administration were observed. These data should contribute to further investigations of the therapeutic potential of LSD in psychiatry.

  2. Women with shaved heads: western Buddhist nuns and Haredi Jewish wives: polysemy, universalism and misinterpretations of hair symbolism in pluralistic societies

    Directory of Open Access Journals (Sweden)

    Mira Niculescu

    2011-01-01

    Full Text Available This article focuses on female hair, or rather the absence of hair: it compares the symbols attached to shaved heads for Western Buddhist nuns and for Jewish married women from various Haredi or ‘ultra-orthodox’ groups, and the (mainly negative representations of these in the external, secular society.The comparison is based on fieldwork research undertaken by the author. When interviewing Western nuns of Jewish origin, it appeared that their shaved heads had been very difficult to cope with for their families, to whom it was a reminder of the Holocaust. The same body treatment can thus represent, on one side, bliss (for the Buddhist nun for whom it is a symbol of libertation and spiritual engagement, and on the other side, horror (for her family and sometimes, out of a Buddhist context, society. Also, the same body treatment can be used to express celibacy for the Buddhist nun, or marriage for the Haredi, or ultra-orthodox woman. Therefore the meaning of head shaving seems to be fluctuating and contextual: it can mean either­ religious commitment, or punishment, or disease.

  3. Young Blood Rejuvenates Old Bodies: A Call for Reflection when Moving from Mice to Men.

    Science.gov (United States)

    Hofmann, Bjørn

    2018-01-01

    Connecting the circulatory system of old and young mice (parabiosis) is documented to have rejuvenating effects on cells, tissues, organs, and functions. A wide range of benefits are envisioned. Blood-based rejuvenation can come to totally change population health and aging. The first blood rejuvenation studies on humans with Alzheimer's disease have started. It puts blood at the center of therapy and revitalizes the historical line of humoral pathology from Hippocrates and Harvey, creating a new type of 'bloodletting.' However, moving from mice to men requires careful consideration. Parabiosis actualizes well-known ethical challenges, such as just distribution of health care, avoiding disparities, and providing equal access to health care resources, as well as issues of human enhancement. However, it also poses new problems. Using internal substances in some persons as means to rejuvenate others calls for ethical reflection. New type of 'blood bonds' may result from the continuous demand for specific types of blood. Even if rejuvenating substances from blood may be artificially and cheaply produced and justly distributed, problems arise: survival may have to be balanced against reproduction, as reproductive age increases. Eternal youth and endless bliss have always been vital human dreams. Although parabiosis may bring us closer to the fountain of youth than ever, it is still too early to provide full-fledged assessments of its implications or to foresee how it will change health, aging, medicine, and society. However, in order to bring our reflective abilities on par with our technical skills, we need to start reflection now.

  4. Combination of Amphotericin B and Flucytosine against Neurotropic Species of Melanized Fungi Causing Primary Cerebral Phaeohyphomycosis

    Science.gov (United States)

    Deng, S.; Pan, W.; Liao, W.; de Hoog, G. S.; Gerrits van den Ende, A. H. G.; Vitale, R. G.; Rafati, H.; Ilkit, M.; Van der Lee, A. H.; Rijs, A. J. M. M.; Verweij, P. E.

    2016-01-01

    Primary central nervous system phaeohyphomycosis is a fatal fungal infection due mainly to the neurotropic melanized fungi Cladophialophora bantiana, Rhinocladiella mackenziei, and Exophiala dermatitidis. Despite the combination of surgery with antifungal treatment, the prognosis continues to be poor, with mortality rates ranging from 50 to 70%. Therefore, a search for a more-appropriate therapeutic approach is urgently needed. Our in vitro studies showed that with the combination of amphotericin B and flucytosine against these species, the median fractional inhibitory concentration (FIC) indices for strains ranged from 0.25 to 0.38, indicating synergy. By use of Bliss independence analysis, a significant degree of synergy was confirmed for all strains, with the sum ΔE ranging from 90.2 to 698.61%. No antagonism was observed. These results indicate that amphotericin B, in combination with flucytosine, may have a role in the treatment of primary cerebral infections caused by melanized fungi belonging to the order Chaetothyriales. Further in vivo studies and clinical investigations to elucidate and confirm these observations are warranted. PMID:26833164

  5. Costs of employee turnover

    Directory of Open Access Journals (Sweden)

    Jiří Duda

    2013-01-01

    Full Text Available The aim of this paper is to establish a general methodology for calculating the costs incurred by employee turnover. This paper deals with identification of costs incurred by the departure of an employee, and does not deal with the cost of recruitment of a new employee. Economic calculations are adjusted to the tax policy in the Czech Republic. The costs of employee turnover (according to Bliss, 2012 include the costs of substitution of the unoccupied position, costs of conducting the exit interview and termination of the contract. The cost of an executive’s time to understand the causes of leaving and costs of the leaving employee’s training were also determined. Important factors in the costs of employee turnover also include the loss of knowledge and possibly also a loss of customers. Costs of lost employee and department productiveness represent an important part of the costs of employee turnover, as well. For all of these costs there have been proposed general calculations formulas.

  6. Teachers Professionalism and The Challenge Of Education In A Global Era

    Directory of Open Access Journals (Sweden)

    Sudrajat Sudrajat

    2017-01-01

    Full Text Available Abstract:  The professional Attitude of a teacher is very necessary for the face of education in this global era. The task of the teacher is not only teaching but also educate, nurture, guide and shape the personality of the student. Mistakes teachers in understanding the profession will result in the shifting of the teacher function slowly. The relationship between teachers and students who need each other turns into a relationship of mutually indifferent, not blissful and boring. The professionalism of teachers is determined by behavior, will and capabilities on condition that Prime. Professionalisation should be viewed as a continuous process, so that the attitude and professional teachers actually formed in this process, pre-service education, educational upgrading, including in his coaching from professional organizations and the workplace, the society against the profession of teacher training, enforcement of the code of ethics of the profession, certification, improved quality of prospective teachers, rewards, etc collectively determine a person including professional development of teachers. This article presents an attempt discussion space for educators, prospective educators, and related parties in order to better understand, implement, and develop attitudes and behavior in the world of education through good example in mind, speech, and action. Keywords: Professional, Teacher, Education, Global Era

  7. The endocannabinoid system: emotion, learning and addiction.

    Science.gov (United States)

    Moreira, Fabrício A; Lutz, Beat

    2008-06-01

    The identification of the cannabinoid receptor type 1 (CB1 receptor) was the milestone discovery in the elucidation of the behavioural and emotional responses induced by the Cannabis sativa constituent Delta(9)-tetrahydrocannabinol. The subsequent years have established the existence of the endocannabinoid system. The early view relating this system to emotional responses is reflected by the fact that N-arachidonoyl ethanolamine, the pioneer endocannabinoid, was named anandamide after the Sanskrit word 'ananda', meaning 'bliss'. However, the emotional responses to cannabinoids are not always pleasant and delightful. Rather, anxiety and panic may also occur after activation of CB1 receptors. The present review discusses three properties of the endocannabinoid system as an attempt to understand these diverse effects. First, this system typically functions 'on-demand', depending on environmental stimuli and on the emotional state of the organism. Second, it has a wide neuro-anatomical distribution, modulating brain regions with different functions in responses to aversive stimuli. Third, endocannabinoids regulate the release of other neurotransmitters that may have even opposing functions, such as GABA and glutamate. Further understanding of the temporal, spatial and functional characteristics of this system is necessary to clarify its role in emotional responses and will promote advances in its therapeutic exploitation.

  8. Ecstatic epileptic seizures: a glimpse into the multiple roles of the insula

    Directory of Open Access Journals (Sweden)

    Markus eGschwind

    2016-02-01

    Full Text Available Ecstatic epileptic seizures are a rare but compelling epileptic entity. During the first seconds of these seizures, ecstatic auras provoke feelings of well-being, intense serenity, bliss, and enhanced self-awareness. They are associated with the impression of time dilation, and can be described as a mystic experience by some patients. The functional neuroanatomy of ecstatic seizures is still debated. During recent years several patients presenting with ecstatic auras have been reported by others and us (in total n=49; a few of them in the setting of presurgical evaluation including electrical brain stimulation. According to the recently recognized functions of the insula, and the results of nuclear brain imaging and electrical stimulation, the ecstatic symptoms in these patients seem to localize to a functional network centered around the anterior insular cortex, where we thus propose to locate this rare ictal phenomenon. Here we summarize the role of the multiple sensory, autonomic, affective and cognitive functions of the insular cortex, which are integrated into the creation of self-awareness, and we suggest how this system may become dysfunctional on several levels during ecstatic aura.

  9. What does it mean to put caribou knowledge into an ecosystem context?

    Directory of Open Access Journals (Sweden)

    Fred H. Harrington

    1998-03-01

    Full Text Available Ecosystems are envisioned as integrated, complex systems with both living and non-living components, that are linked through processes of energy flow and nutrient cycling (Bowen, 1971; Ricklefs, 1979. The ecosystem approach seeks to describe the components of this system, the pathways through which energy and nutrients move, and the processes that govern that movement. The goal is a better understanding of the role or effect of each component (abiotic or biotic within the system. Theorerically, the more we know, the better we can predict the future behaviour of the ecosystem and therefore manage the system on whatever sustainable basis we deem appropriate. Caribou (Rangifer tarandus presently inhabit two ecosystems, tundra (arctic and alpine and taiga (or boreal forest, both characterized by relatively low productivity and diversity (Bowen, 1971; Bliss, 1981; Bonan, 1992a. As increased anthropogenic impacts are expected in these ecosystems through the next century, our ability to ensure the continued survival of caribou requires that we pay increasing attention to the processes that drive these systems. In this endeavour, an awareness of the effects of both spatial and temporal scale, in both ecosystem processes and our research programs to understand those processes, is critical.

  10. [The myth of the good savage].

    Science.gov (United States)

    Yampey, N

    1994-09-01

    The conquest of the New World gave way to the myth of the Good Savage. For the Renaissance intellectuals, the ancient ideas about the Golden Age (an ideal society promising an unending bliss) seemed to be brought back to life at last. Sharply contrasting with the European exacerbated unrest of the time, America stood for a redeeming hope, a symbol of a better future. The myth of the Good Savage assumes people to be naturally good, but civilization has led them into the realm of violence, hatred, and cruelty. Besides being naturally good, nice-minded people, "good savages" were also useful, obedient people, most likely to be easily exploited by Europeans--a source for the historical drama to come. On the verge of freeing itself from the Spanish rule, Latin America--fighting its way toward independence, had three enlightened mentors: Voltaire, Rousseau, and Montesquieu. There, again, another deep contrast arose between the abstract characteristics of Latin American aims to perfection, and people's actual behaviors. The former "good savage" became the modern "Latin American" embodying an utopia as well as a hope in his eagerness for setting up a plural, and humanized culture. The myth of the Good Savage represents a deep longing for an objectivation of the ego-ideal: it has been used, so to speak, in collective mobilizations as well as dogmatic crystallizations, to escape from ignominous realities or to project alternatives for a better socially-shared life.

  11. Engineered Cpf1 variants with altered PAM specificities.

    Science.gov (United States)

    Gao, Linyi; Cox, David B T; Yan, Winston X; Manteiga, John C; Schneider, Martin W; Yamano, Takashi; Nishimasu, Hiroshi; Nureki, Osamu; Crosetto, Nicola; Zhang, Feng

    2017-08-01

    The RNA-guided endonuclease Cpf1 is a promising tool for genome editing in eukaryotic cells. However, the utility of the commonly used Acidaminococcus sp. BV3L6 Cpf1 (AsCpf1) and Lachnospiraceae bacterium ND2006 Cpf1 (LbCpf1) is limited by their requirement of a TTTV protospacer adjacent motif (PAM) in the DNA substrate. To address this limitation, we performed a structure-guided mutagenesis screen to increase the targeting range of Cpf1. We engineered two AsCpf1 variants carrying the mutations S542R/K607R and S542R/K548V/N552R, which recognize TYCV and TATV PAMs, respectively, with enhanced activities in vitro and in human cells. Genome-wide assessment of off-target activity using BLISS indicated that these variants retain high DNA-targeting specificity, which we further improved by introducing an additional non-PAM-interacting mutation. Introducing the identified PAM-interacting mutations at their corresponding positions in LbCpf1 similarly altered its PAM specificity. Together, these variants increase the targeting range of Cpf1 by approximately threefold in human coding sequences to one cleavage site per ∼11 bp.

  12. Engineered Cpf1 variants with altered PAM specificities increase genome targeting range

    Science.gov (United States)

    Gao, Linyi; Cox, David B.T.; Yan, Winston X.; Manteiga, John C.; Schneider, Martin W.; Yamano, Takashi; Nishimasu, Hiroshi; Nureki, Osamu; Crosetto, Nicola; Zhang, Feng

    2017-01-01

    The RNA-guided endonuclease Cpf1 is a promising tool for genome editing in eukaryotic cells1–7. However, the utility of the commonly used Acidaminococcus sp. BV3L6 Cpf1 (AsCpf1) and Lachnospiraceae bacterium ND2006 Cpf1 (LbCpf1) is limited by their requirement of a TTTV protospacer adjacent motif (PAM) in the DNA substrate. To address this limitation, we performed a structure-guided mutagenesis screen to increase the targeting range of Cpf1. We engineered two AsCpf1 variants carrying the mutations S542R/K607R and S542R/K548V/N552R, which recognize TYCV and TATV PAMs, respectively, with enhanced activities in vitro and in human cells. Genome-wide assessment of off-target activity using BLISS7 assay indicated that these variants retain high DNA targeting specificity, which we further improved by introducing an additional non-PAM-interacting mutation. Introducing the identified mutations at their corresponding positions in LbCpf1 similarly altered its PAM specificity. Together, these variants increase the targeting range of Cpf1 by approximately three-fold in human coding sequences to one cleavage site per ~11 bp. PMID:28581492

  13. Modelling avian biodiversity using raw, unclassified satellite imagery.

    Science.gov (United States)

    St-Louis, Véronique; Pidgeon, Anna M; Kuemmerle, Tobias; Sonnenschein, Ruth; Radeloff, Volker C; Clayton, Murray K; Locke, Brian A; Bash, Dallas; Hostert, Patrick

    2014-01-01

    Applications of remote sensing for biodiversity conservation typically rely on image classifications that do not capture variability within coarse land cover classes. Here, we compare two measures derived from unclassified remotely sensed data, a measure of habitat heterogeneity and a measure of habitat composition, for explaining bird species richness and the spatial distribution of 10 species in a semi-arid landscape of New Mexico. We surveyed bird abundance from 1996 to 1998 at 42 plots located in the McGregor Range of Fort Bliss Army Reserve. Normalized Difference Vegetation Index values of two May 1997 Landsat scenes were the basis for among-pixel habitat heterogeneity (image texture), and we used the raw imagery to decompose each pixel into different habitat components (spectral mixture analysis). We used model averaging to relate measures of avian biodiversity to measures of image texture and spectral mixture analysis fractions. Measures of habitat heterogeneity, particularly angular second moment and standard deviation, provide higher explanatory power for bird species richness and the abundance of most species than measures of habitat composition. Using image texture, alone or in combination with other classified imagery-based approaches, for monitoring statuses and trends in biological diversity can greatly improve conservation efforts and habitat management.

  14. Concept and canons of fasting in Ayurveda

    Directory of Open Access Journals (Sweden)

    H Shripathi Adiga

    2013-03-01

    Full Text Available Ayurveda, manoeuvres mankind to head a healthy life in order to pursue four-fold bliss. With a view to combat physical and mental annoyances, classics have explicated two-fold therapeutic modalities; langhana/depletion and brihmana/nourishing. Upavasa /fasting is one among ten depletion therapies explained. It is envisioned at all three levels of Ayurvedic therapies- rational/objectively planned, psychological, and spiritual. Fasting is reckoned to be refraining from all forms of food intake for a given period, under supervision of a qualified physician. Acharya Charaka advocates fasting in diseases of milder intensity, in those due to aama (metabolic toxin, after purificatory procedures. Fasting person should avoid beautifying oneself, day sleep, sexual acts, and feasting prior and ulterior to fasting. Fasting is contraindicated in very young, elderly, emaciated, pregnant lady, and shortly after strenuous exercise. The principle avers that fasting kindles metabolic/digestive fire which, in absence of food, brings about paachana of vitiated doshas, thereby riposting health. Sound fasting ensues proper elimination of excretory wastes, clear belch, sweat, and taste for food. Benefits of fasting include lucidity of sense organs, lightness of body and mind, control of diseases, and enthusiasm. Yoga Shastra describes fasting with respect to three levels of food: physical, impressions, and associations and a means to unite three bodies: astral, physical, and causal. Ayurveda thus advocates fasting depending upon the dosha, agni, vaya, kala, and bala of the individual, as a preventive as well as therapeutic modality.

  15. The Einstein Genome Gateway using WASP - a high throughput multi-layered life sciences portal for XSEDE.

    Science.gov (United States)

    Golden, Aaron; McLellan, Andrew S; Dubin, Robert A; Jing, Qiang; O Broin, Pilib; Moskowitz, David; Zhang, Zhengdong; Suzuki, Masako; Hargitai, Joseph; Calder, R Brent; Greally, John M

    2012-01-01

    Massively-parallel sequencing (MPS) technologies and their diverse applications in genomics and epigenomics research have yielded enormous new insights into the physiology and pathophysiology of the human genome. The biggest hurdle remains the magnitude and diversity of the datasets generated, compromising our ability to manage, organize, process and ultimately analyse data. The Wiki-based Automated Sequence Processor (WASP), developed at the Albert Einstein College of Medicine (hereafter Einstein), uniquely manages to tightly couple the sequencing platform, the sequencing assay, sample metadata and the automated workflows deployed on a heterogeneous high performance computing cluster infrastructure that yield sequenced, quality-controlled and 'mapped' sequence data, all within the one operating environment accessible by a web-based GUI interface. WASP at Einstein processes 4-6 TB of data per week and since its production cycle commenced it has processed ~ 1 PB of data overall and has revolutionized user interactivity with these new genomic technologies, who remain blissfully unaware of the data storage, management and most importantly processing services they request. The abstraction of such computational complexity for the user in effect makes WASP an ideal middleware solution, and an appropriate basis for the development of a grid-enabled resource - the Einstein Genome Gateway - as part of the Extreme Science and Engineering Discovery Environment (XSEDE) program. In this paper we discuss the existing WASP system, its proposed middleware role, and its planned interaction with XSEDE to form the Einstein Genome Gateway.

  16. An integral investigation into the phenomenology and neurophysiology of Christian Trinity meditation

    Directory of Open Access Journals (Sweden)

    Stephen D. Edwards

    2012-03-01

    Full Text Available This integral investigation explored phenomenological and neurophysiologic, individual and collective dimensions of Christian Trinitarian meditation experiences in a volunteer, convenience sample of 10 practicing Christians, 6 men and 4 women, with a mean age of 48 years and an age range from 21 to 85 years. Participants meditated for a minimum period of 15 minutes, during which neurophysiologic data in the form of electroencephalographic (EEG, electromyographic (EMG, blood volume pulse (BVP and respiratory activity were recorded. A phenomenological analysis indicated that the meditation process generally involved a movement from body to mind to spirit as evident in reports of an increasingly relaxed, contented and focused state of consciousness characterised by Christian Trinitarian imagery, wonder, surrender, peace, bliss, openness and formlessness. The neuropsychological findings indicated significant increases, from baseline to meditation recordings, in the alpha and beta range, accompanied by increasing mean trends in the theta and gamma range, and decreasing mean trends in the delta range, EMG, BVP and respiration. Integrative findings indicated the practical theological value of small doses of Christian Trinity meditation to enhance spiritual life for those forms of waking, thinking, conscious behaviour needed in everyday world involvement and healing. Findings were discussed in relation to further integrative investigations and interventions with practical theological implications.

  17. Narrative Finality

    Directory of Open Access Journals (Sweden)

    Armine Kotin Mortimer

    1981-01-01

    Full Text Available The cloturai device of narration as salvation represents the lack of finality in three novels. In De Beauvoir's Tous les hommes sont mortels an immortal character turns his story to account, but the novel makes a mockery of the historical sense by which men define themselves. In the closing pages of Butor's La Modification , the hero plans to write a book to save himself. Through the thrice-considered portrayal of the Paris-Rome relationship, the ending shows the reader how to bring about closure, but this collective critique written by readers will always be a future book. Simon's La Bataille de Pharsale , the most radical attempt to destroy finality, is an infinite text. No new text can be written. This extreme of perversion guarantees bliss (jouissance . If the ending of De Beauvoir's novel transfers the burden of non-final world onto a new victim, Butor's non-finality lies in the deferral to a future writing, while Simon's writer is stuck in a writing loop, in which writing has become its own end and hence can have no end. The deconstructive and tragic form of contemporary novels proclaims the loss of belief in a finality inherent in the written text, to the profit of writing itself.

  18. Gombrowicz’s “anti-naturalism”, or why should ecocriticism remember modernity

    Directory of Open Access Journals (Sweden)

    Martyna Pańczak

    2018-05-01

    Full Text Available The article discusses Gombrowicz’s declared “anti-naturalism”, which is often seen as a gesture of negating the non-human world as boring and unworthy of interacting with. Nevertheless, this seemingly radical anthropocentrism does not imply absolute indifference. On the contrary, human anti-naturalness, as emphasized in the work of Gombrowicz, is considered arbitrary, founded on logocentrism and influential interpersonal doctrines. It may therefore be a tragic experience – depriving of a sense of belonging, but also deflating self-confidence, which is grounded in the belief in nature’s otherness. Gombrowicz’s “anti-naturalism”, crucial for the experience of modernity, relates to the problem of definition. The aversion to the non-human is, in fact, the fear of recognising one’s own non-identity; the angst caused by blurring the boundaries that used to arrange the world. It also leads to ignorance, cruelty and a state of “blissful unawareness” on the issues of animal others. In this respect, the writer’s remarks can be very inspiring for ecocritical thought. Gombrowicz once again reminds the reader of the necessity to stop conceiving “Human” as stable, homogenic and self-assured identity and for that reason, collaboration between ecocriticism and posthumanist critical approaches seems unavoidable.

  19. The life and work of Ksenija Atanasijević (1894-1981)--psychology and anthropology as the inevitability and necessity of philosophy.

    Science.gov (United States)

    Damjanović, Aleksandar; Milovanović, Srdan; Jovanović, Aleksandar; Cvetić, Tijana; Jasović-Gasić, Miroslava

    2014-06-01

    Ksenja Atanasijević (1894-1981) was the first woman in Serbia to obtain a Ph.D. in philosophy. Going through numerous psychological metamorphoses in her lifetime and confronted with numerous challenges, Ksenija Atanasijević developed a specific philosophical-psychological system of consolation prominently featuring the concepts of happiness, bliss, moderation, courage and wisdom. Modifying the original teachings of Democritus and Epicurus, Ksenija Atanasijević developed a distinctive anthropology based on confrontation with but equally the overcoming of obstacles, both internal (spiritual) as well as external ones. The philosopheress developed a reflexive and indeed metaphysical defensive psychotherapeutical skill at the root of which was cleansing the soul, as well as dedication to the realm of fancy, fantasy and imagination. Ksenija Atanasijević also had precious literary talent which was best expressed in her analyses of the poetry and prose of great Serbian writers (Pandurović, Njegos, Nastasijević, etc.). It is quite certain that this, with Anica Savić-Rebac, definitely greatest Serbian philosopheress, through personal suffering, creative solitude and shrouded desperation built an utterly authentic and harmonious system of philosophical comfort.

  20. In Defence of the Textual Integrity of the Old English Resignation

    Directory of Open Access Journals (Sweden)

    Sobol Helena W.

    2015-03-01

    Full Text Available Bliss & Frantzen’s (1976 paper against the previously assumed textual integrity of Resignation has been a watershed in research upon the poem. Nearly all subsequent studies and editions have followed their theory, the sole dissenting view being expressed by Klinck (1987, 1992. The present paper offers fresh evidence for the textual unity of the poem. First examined are codicological issues, whether the state of the manuscript suggests that a folio might be missing. Next analysed are the spellings of Resignation and its phonology, here the paper discusses peculiarities which both differentiate Resignation from its manuscript context and connect the two hypothetical parts of the text. Then the paper looks at the assumed cut-off point at l.69 to see if it may provide any evidence for textual discontinuity. Finally the whole Resignation, seen as a coherent poem, is placed in the history of Old English literature, with special attention being paid to the traditions of devotional texts and the Old English elegies.

  1. Immortality in view of Maimonides and Spinoza

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    Morteza Shajari

    2014-12-01

    Full Text Available Desire for immortality can be seen as the essential natural impulse. Therefore, different religions and thinkers have attempted to see the issue from different viewpoints. The great Jewish philosopher. Maimonides, due to deep fixation to Judaism, has tried to express their issues to be consistent with the Bible and his own community believes. He, in his discussion of resurrection, believed to three basic steps: The Messiah, the resurrection, and the world hereafter. His standpoint of eternity is dedicated to the hereafter. And we can be immortalized only by acting and teachings in accordance with the Bible and righteousness. Like Maimonides, Spinoza – the other Jewish philosopher - considered the immortality as Ultimate bliss through which the “immutable and eternal love of God" can be achieved. In his opinion, a person reaches this stage, when the lusts and emotions can reasonably be overcome, and also, when the power and anger and contempt and disregard others will respond with love and dignity. Thus, a man can be reached its proper perfection and immortality is reached. The difference between these two philosophers is that Maimonides believes through "actual intellect" -that is Emanation of the active intellect- can be immortalized but, for Spinoza, eternity can be reached through the adequate Ideas.

  2. Transmutations: Rejuvenation, Longevity, and Immortality Practices in South and Inner Asia

    Directory of Open Access Journals (Sweden)

    Dagmar Wujastyk

    2017-12-01

    Full Text Available Wild and diverse outcomes are associated with transmutational practices: the prolongation of life, the recovery of youth, the cure of diseases, invincibility, immortality, enlightenment, liberation from the cycle of rebirths, and unending bliss. This range of outcomes is linked to specific practices taught in separate traditions and lineages in medical, alchemical, yogic and tantric milieus across South and Inner Asia. These practices can be individual or collective, esoteric or secular, and occur in different places from hospital to village to monastery; they involve transmutations of substances as well as transmutations of the body. Every expression by a particular lineage has a distinguishing articulation. Yet there are also very clear commonalities and interconnections between the traditions’ aims, methods and expected results. In this special issue of HSSA, we examine transmutational practices and their underlying concepts in this wider context of South and Inner Asian culture. How do these practices and ideas connect and cross-fertilise? And conversely, how are they delineated and distinct?

  3. Music as a therapy: role in psychiatry.

    Science.gov (United States)

    Solanki, Madhusudan Singh; Zafar, Mehnaz; Rastogi, Rajesh

    2013-06-01

    Music is popularly believed to usher in bliss and serenity, and healing is considered its natural quality. It has an emotionally charging charisma of its own, that we all as listeners might have experienced at times. Music has been there with mankind since the beginning of history, but where does it stand as a therapy? Is there any evidence base? How this therapy came into being and how it has evolved, and what the old and current research says about its role in psychiatric disorders. This review tries to explore these questions and arrives at a conclusion that music certainly promises more than just entertainment, and evidence so far suggests music therapy can be beneficial in the treatment of psychiatric disorders, as a cost effective noninvasive adjunct to standard therapy in a variety of settings and patient groups, yet more validated scientific research is still required to establish it as a sole quantified therapy. Copyright © 2012 Elsevier B.V. All rights reserved.

  4. Hypnagogic and hypnopompic hallucinations during sleep paralysis: neurological and cultural construction of the night-mare.

    Science.gov (United States)

    Cheyne, J A; Rueffer, S D; Newby-Clark, I R

    1999-09-01

    Hypnagogic and hypnopompic experiences (HHEs) accompanying sleep paralysis (SP) are often cited as sources of accounts of supernatural nocturnal assaults and paranormal experiences. Descriptions of such experiences are remarkably consistent across time and cultures and consistent also with known mechanisms of REM states. A three-factor structural model of HHEs based on their relations both to cultural narratives and REM neurophysiology is developed and tested with several large samples. One factor, labeled Intruder, consisting of sensed presence, fear, and auditory and visual hallucinations, is conjectured to originate in a hypervigilant state initiated in the midbrain. Another factor, Incubus, comprising pressure on the chest, breathing difficulties, and pain, is attributed to effects of hyperpolarization of motoneurons on perceptions of respiration. These two factors have in common an implied alien "other" consistent with occult narratives identified in numerous contemporary and historical cultures. A third factor, labeled Unusual Bodily Experiences, consisting of floating/flying sensations, out-of-body experiences, and feelings of bliss, is related to physically impossible experiences generated by conflicts of endogenous and exogenous activation related to body position, orientation, and movement. Implications of this last factor for understanding of orientational primacy in self-consciousness are considered. Central features of the model developed here are consistent with recent work on hallucinations associated with hypnosis and schizophrenia. Copyright 1999 Academic Press.

  5. Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations

    Science.gov (United States)

    Laird, Gregory M.; Bullen, C. Korin; Rosenbloom, Daniel I.S.; Martin, Alyssa R.; Hill, Alison L.; Durand, Christine M.; Siliciano, Janet D.; Siliciano, Robert F.

    2015-01-01

    Reversal of HIV-1 latency by small molecules is a potential cure strategy. This approach will likely require effective drug combinations to achieve high levels of latency reversal. Using resting CD4+ T cells (rCD4s) from infected individuals, we developed an experimental and theoretical framework to identify effective latency-reversing agent (LRA) combinations. Utilizing ex vivo assays for intracellular HIV-1 mRNA and virion production, we compared 2-drug combinations of leading candidate LRAs and identified multiple combinations that effectively reverse latency. We showed that protein kinase C agonists in combination with bromodomain inhibitor JQ1 or histone deacetylase inhibitors robustly induce HIV-1 transcription and virus production when directly compared with maximum reactivation by T cell activation. Using the Bliss independence model to quantitate combined drug effects, we demonstrated that these combinations synergize to induce HIV-1 transcription. This robust latency reversal occurred without release of proinflammatory cytokines by rCD4s. To extend the clinical utility of our findings, we applied a mathematical model that estimates in vivo changes in plasma HIV-1 RNA from ex vivo measurements of virus production. Our study reconciles diverse findings from previous studies, establishes a quantitative experimental approach to evaluate combinatorial LRA efficacy, and presents a model to predict in vivo responses to LRAs. PMID:25822022

  6. Multi-step inhibition explains HIV-1 protease inhibitor pharmacodynamics and resistance

    Science.gov (United States)

    Rabi, S. Alireza; Laird, Gregory M.; Durand, Christine M.; Laskey, Sarah; Shan, Liang; Bailey, Justin R.; Chioma, Stanley; Moore, Richard D.; Siliciano, Robert F.

    2013-01-01

    HIV-1 protease inhibitors (PIs) are among the most effective antiretroviral drugs. They are characterized by highly cooperative dose-response curves that are not explained by current pharmacodynamic theory. An unresolved problem affecting the clinical use of PIs is that patients who fail PI-containing regimens often have virus that lacks protease mutations, in apparent violation of fundamental evolutionary theory. Here, we show that these unresolved issues can be explained through analysis of the effects of PIs on distinct steps in the viral life cycle. We found that PIs do not affect virion release from infected cells but block entry, reverse transcription, and post–reverse transcription steps. The overall dose-response curves could be reconstructed by combining the curves for each step using the Bliss independence principle, showing that independent inhibition of multiple distinct steps in the life cycle generates the highly cooperative dose-response curves that make these drugs uniquely effective. Approximately half of the inhibitory potential of PIs is manifest at the entry step, likely reflecting interactions between the uncleaved Gag and the cytoplasmic tail (CT) of the Env protein. Sequence changes in the CT alone, which are ignored in current clinical tests for PI resistance, conferred PI resistance, providing an explanation for PI failure without resistance. PMID:23979165

  7. A pragmatic definition of therapeutic synergy suitable for clinically relevant in vitro multicompound analyses.

    Science.gov (United States)

    Kashif, Muhammad; Andersson, Claes; Åberg, Magnus; Nygren, Peter; Sjöblom, Tobias; Hammerling, Ulf; Larsson, Rolf; Gustafsson, Mats G

    2014-07-01

    For decades, the standard procedure when screening for candidate anticancer drug combinations has been to search for synergy, defined as any positive deviation from trivial cases like when the drugs are regarded as diluted versions of each other (Loewe additivity), independent actions (Bliss independence), or no interaction terms in a response surface model (no interaction). Here, we show that this kind of conventional synergy analysis may be completely misleading when the goal is to detect if there is a promising in vitro therapeutic window. Motivated by this result, and the fact that a drug combination offering a promising therapeutic window seldom is interesting if one of its constituent drugs can provide the same window alone, the largely overlooked concept of therapeutic synergy (TS) is reintroduced. In vitro TS is said to occur when the largest therapeutic window obtained by the best drug combination cannot be achieved by any single drug within the concentration range studied. Using this definition of TS, we introduce a procedure that enables its use in modern massively parallel experiments supported by a statistical omnibus test for TS designed to avoid the multiple testing problem. Finally, we suggest how one may perform TS analysis, via computational predictions of the reference cell responses, when only the target cell responses are available. In conclusion, the conventional error-prone search for promising drug combinations may be improved by replacing conventional (toxicology-rooted) synergy analysis with an analysis focused on (clinically motivated) TS. ©2014 American Association for Cancer Research.

  8. Optimising measles virus-guided radiovirotherapy with external beam radiotherapy and specific checkpoint kinase 1 inhibition

    International Nuclear Information System (INIS)

    Touchefeu, Yann; Khan, Aadil A.; Borst, Gerben; Zaidi, Shane H.; McLaughlin, Martin; Roulstone, Victoria; Mansfield, David; Kyula, Joan; Pencavel, Tim; Karapanagiotou, Eleni M.; Clayton, Jamie; Federspiel, Mark J.; Russell, Steve J.; Garrett, Michelle; Collins, Ian; Harrington, Kevin J.

    2013-01-01

    Background and purpose: We previously reported a therapeutic strategy comprising replication-defective NIS-expressing adenovirus combined with radioiodide, external beam radiotherapy (EBRT) and DNA repair inhibition. We have now evaluated NIS-expressing oncolytic measles virus (MV-NIS) combined with NIS-guided radioiodide, EBRT and specific checkpoint kinase 1 (Chk1) inhibition in head and neck and colorectal models. Materials and methods: Anti-proliferative/cytotoxic effects of individual agents and their combinations were measured by MTS, clonogenic and Western analysis. Viral gene expression was measured by radioisotope uptake and replication by one-step growth curves. Potential synergistic interactions were tested in vitro by Bliss independence analysis and in in vivo therapeutic studies. Results: EBRT and MV-NIS were synergistic in vitro. Furthermore, EBRT increased NIS expression in infected cells. SAR-020106 was synergistic with EBRT, but also with MV-NIS in HN5 cells. MV-NIS mediated 131 I-induced cytotoxicity in HN5 and HCT116 cells and, in the latter, this was enhanced by SAR-020106. In vivo studies confirmed that MV-NIS, EBRT and Chk1 inhibition were effective in HCT116 xenografts. The quadruplet regimen of MV-NIS, virally-directed 131 I, EBRT and SAR-020106 had significant anti-tumour activity in HCT116 xenografts. Conclusion: This study strongly supports translational and clinical research on MV-NIS combined with radiation therapy and radiosensitising agents

  9. In the Midst of Life-Cell Death: What Is It, What Is It Good for, and How to Study It.

    Science.gov (United States)

    Silke, John; Johnstone, Ricky W

    2016-12-01

    Cell death, one of the most fundamental biological processes, has not made it into the public consciousness in the same way that genetic inheritance, cell division, or DNA replication has. Everyone knows they get their genes from their parents, but few would be aware that even before they were born a lot of essential cell death has shaped their development. The greater population, for the most part, is blissfully unaware that every day millions of their own cells die in a programmed way and that this is essential for normal human physiology-their well-being, in fact. Nowhere is the burial liturgy, "In the midst of life we are in death," more apt. Despite this public underappreciation, cell death research is a major industry. A search in PubMed for "apoptosis," a special form of cell death that is caused by caspases, returns approximately 280,000 hits. The intense research interest arises from the realization that abnormal cell death responses play an important role in two of the biggest killers in the western world: cancer and cardio/cerebrovascular disease. Furthermore, the manner in which cells die can also influence the development of autoimmune and autoinflammatory diseases. It is therefore of paramount importance to ensure that experiments accurately quantitate and correctly identify cell death in all its guises. That is the goal of this protocol collection. © 2016 Cold Spring Harbor Laboratory Press.

  10. Combined Effects of Nonylphenol and Bisphenol A on the Human Prostate Epithelial Cell Line RWPE-1

    Directory of Open Access Journals (Sweden)

    Weidong Gan

    2015-04-01

    Full Text Available The xenoestrogens nonylphenol (NP and bisphenol A (BPA are regarded as endocrine disrupting chemicals (EDCs which have widespread occurrence in our daily life. In the present study, the purpose was to analyze the combined effects of NP and BPA on the human prostate epithelial cell line RWPE-1 using two mathematical models based on the Loewe additivity (LA theory and the Bliss independence (BI theory. RWPE-1 cells were treated with NP (0.01–100 µM and BPA (1–5000 µM in either a single or a combined format. A cell viability assay and lactate dehydrogenase (LDH leakage rate assay were employed as endpoints. As predicted by the two models and based on the cell viability assay, significant synergism between NP and BPA were observed. However, based on the LDH assay, the trends were reversed. Given that environmental contaminants are frequently encountered simultaneously, these data indicated that there were potential interactions between NP and BPA, and the combined effects of the chemical mixture might be stronger than the additive values of individual chemicals combined, which should be taken into consideration for the risk assessment of EDCs.

  11. [Weizsäcker and Indian philosophy - a new beginning in negotiating the dualism of mind and matter?].

    Science.gov (United States)

    von Brück, Michael

    2014-01-01

    Carl Friedrich von Weizsäcker's thought is centred around the idea of the unity of reality. He tries to express this idea in his interpretation of quantum physics as well as on the background of neoplatonic thinking. Even his interest in Indian philosophies is based on this concept that would overcome the dualism of mind and matter as well as the dualism of subject and object. On this basis he also tries to reflect on his own inexpressible "mystical" experience in Tiruvannamalai, India, interpreting it with the help of the experience he has been told about by the Indian thinker Gopi Krishna. This is the concept of prana (vital energy) that he uses to find a common terminological ground for physical and mental events. According to Indian Advaita Vedanta, the non-dualistic interpretation of the Vedantic scriptures, reality is based on a non-dual oneness that is self-reflective, transparent and neither immanent nor transcendent but beyond any category. It is pure bliss in its self-expression. Human "mental" experience is a reflective mode of this one reality, subject and object coincide. The result is a holistic psycho-somatology. In view of these ideas Weizsäcker reformulates the notion of "matter". It is less an interaction of particles with specific mass than a non-dual net of interrelations and information, and this would correlate with a concept of mind (consciousness) that could be conceptualized as the energy of self-reflectivity in that very process.

  12. DDC(Dewey Decimal Classification)の実効性を比較検証する : 日本の教育事情に対する付与実験をもとに

    OpenAIRE

    藤倉, 恵一

    2006-01-01

    国際標準的な図書分類法として知られるデューイ十進分類法(DDC: Dewey Decimal Classification)は、改訂のたび部門ごとに中規模~大規模な改訂が実施されている。前期のブリス書誌分類法(BC2: Bliss Bibliographic Classification 2nd ed.)と同様の評価手法を用いてDDC諸般(最新の22版、大規模改訂後の21版、改訂前の20版、そして戦前の13版)の性能比較・検証を行い、その実効性から専門資料群を扱う大学図書館に必要な分類法のありようを考えたい。...

  13. Valoraciones sobre la gestión del sistema de seguridad vial en Cuba.

    Directory of Open Access Journals (Sweden)

    Tania Ivón Sosa Ibarra

    2015-12-01

    Full Text Available El presente trabajo tiene como objetivo valorar con enfoque crítico el cumplimiento de la agenda del Observatorio Iberoamericano para la Seguridad Vial (OISEVI que evidencie los aciertos y desaciertos en esta actividad, se analiza en la literatura los enfoques de los autores Tony Bliss y Jeanne Breen que enfatizan en la concepción de sistema no solo a la seguridad vial sino también a la gestión de esta como sistema y se realiza una aplicación de los aspectos de la encuesta del OISEVI a la gestión de la seguridad vial en Cuba por el grupo de asesores de la Comisión Nacional de seguridad vial, pertenecientes a la Universidad de Sancti Spíritus, que durante los últimos años estudian esta problemática, detallando los argumentos que conciben para otorgar los valores en las respuestas al cuestionario. Con esta encuesta se obtiene una primera aproximación del estado de la gestión de la seguridad vial en el país, y se arriban a valoraciones acerca de cómo se encuentra Cuba respecto a los lineamientos básicos y generales que hacen exitosa a la gestión en seguridad vial, basada en los cinco pilares del Plan Mundial para el Decenio de Acción para la Seguridad Vial 2011-2020.

  14. Female genital mutilation as sexual disability: perceptions of women and their spouses in Akure, Ondo State, Nigeria.

    Science.gov (United States)

    Owojuyigbe, Michael; Bolorunduro, Miracle-Eunice; Busari, Dauda

    2017-05-01

    Disability encompasses the limitations on an individual's basic physical activities, and the consequent social oppressions such individual faces in society. In this regard, the limitation on the use of some parts of the genitals in a patriarchal system is considered a form of disability. This paper describes the perceptions of and the coping mechanisms employed by affected couples dealing with the consequences of female genital mutilation (FGM) as a form of sexual disability. Cultural Libertarianism was employed as a theoretical framework. The paper presents the results of a descriptive cross-sectional study conducted in Akure, Ondo State, Nigeria, with 10 male and 12 female respondents purposively selected through a snowball sampling for in-depth interviews. The findings present the justifications provided for the practice of FGM, and victims' perceptions of how it affects their sexual relations. Furthermore, it highlights coping strategies employed by affected women and their spouses. The study shows that the disabling consequence of FGM is largely sexual in nature, leading to traumatic experiences and negative beliefs about sex, and requiring a myriad of coping strategies employed by the disabled women, and their spouses, which may have its own implications for marital and sexual bliss.

  15. Editorial zum Tagungsband: Spannungsfelder und blinde Flecken. Medienpädagogik zwischen Emanzipationsanspruch und Diskursvermeidung

    Directory of Open Access Journals (Sweden)

    Sven Kommer

    2017-10-01

    Full Text Available Die erziehungswissenschaftliche Auseinandersetzung mit Medien hat in Deutschland eine lange und vielfältige Tradition. In den letzten Jahrzehnten hat sich die Medienpädagogik zu einer eigenständigen akademischen (Teil-Disziplin entwickelt, die in der (Fach-Öffentlichkeit wahrgenommen wird und sich aktiv in aktuelle gesellschaftliche Diskurse einbringt. Sichtbar wird die Etablierung als Fach u. a. daran, dass an einer Reihe von Hochschulen Professuren geschaffen wurden, die für medienpädagogische Studienelemente oder -gänge und/oder Zusatzausbildungen verantwortlich sind. Der gestiegene Stellenwert der Disziplin zeigt sich auch an ihrer Rolle in der Deutschen Gesellschaft für Erziehungswissenschaft, innerhalb derer sie sich von einer «Arbeitsgemeinschaft auf Zeit» (Mitte der 1990er-Jahre zu einer eigenständigen Sektion (seit 2010 entwickelt hat. Angesichts der gegenwärtig zu beobachtenden Entwicklungen im Medienbereich (u. a. Digitalisierung, Globalisierung, Algorithmisierung, deren Folgen für gesellschaftliche und pädagogische Prozesse und Bereiche kaum zu unterschätzen sind, erstaunt es, dass die Medienpädagogik bis heute dazu neigt, Rechtfertigungsstrategien für die eigenen Existenz zu generieren. Bei einer kritischen Betrachtung (z. B. der universitären Stellenpolitik ist aber zu konstatieren, dass sich die Medienpädagogik auch 40 Jahre nach dem Erscheinen von Dieter Baackes wegweisender Schrift Kommunikation und Kompetenz ihrer Anerkennung und festen Verankerung im akademischen Feld tatsächlich noch immer nicht sicher sein kann. Eine Ursache hierfür liegt möglicherweise in der noch immer grossen (und oftmals geradezu zelebrierten Heterogenität des Faches. So sind die unterschiedlichen Traditionslinien des pädagogischen Umgangs mit Medien, die mitunter nur bedingt miteinander vereinbar sind, bis heute zu beobachten und wirkmächtig. Zu unterscheiden ist hierbei bspw. eine auf Emanzipation, kommunikative Kompetenz

  16. Experiment und Wissensvermittlung. Alexander von Humboldts Darstellungsmethoden in seinen Versuchen über die gereizte Muskel- und Nervenfaser

    Directory of Open Access Journals (Sweden)

    Alexander Stöger

    2016-11-01

    Full Text Available Zusammenfassung Alexander von Humboldt hat sich in jungen Jahren mit galvanischen Experimenten beschäftigt und die Resultate in einem umfassenden, zweibändigen Werk publiziert. Dabei zeigte er nicht nur, dass er als Experimentator und Teil der wissenschaftlichen Gemeinschaft fähig war, sich mit einem so neuen und komplexen Phänomen zu beschäftigen. Es lässt sich auch erkennen, dass er bereits in dieser frühen Schrift versuchte, das umfangreiche Wissen dem Leser zugänglich zu machen. Der Artikel betrachtet Humboldts Galvanismusschrift Versuche über die gereizte Muskel- und Nervenfaser (1797–1798 und untersucht einige Elemente wie Anhänge und Schreibstil, die Humboldt nutzte, um die umfangreichen Informationen zu ordnen und dem Leser so neben den Big Data seiner Erkenntnisse auch passende Suchfunktionen zur Verfügung zu stellen, die eine gezielte Nutzung überhaupt ermöglichen.  Abstract In the early stages of his scientific career, Alexander von Humboldt took an interest in experiments in galvanism. He publicised the results in a two-volume work under the title Versuche über die gereizte Muskel- und Nervenfaser (Experiments on the Stimulated Muscle and Nerve Fibre in 1797 and 1798. In this treatise, he presented himself as competent experimenter and member of the scientific community, but also demonstrated that he was capable of researching new and complex phenomena. These volumes also provide insight into his early attempts to facilitate the readers’ access to the extensive information he had compiled. This article analyses some aspects of Humboldt’s efforts to arrange his vast numbers of observations and theories, for example by means of appendices and narrative style, which he used not only to present the resulting big data collected during his research, but also to make it possible for the reader to organise and utilise this data.   Resumen A temprana edad Alexander von Humboldt se dedicó a galvanismo. En 1797 y 1798

  17. Editorial 01/2013 Normen und Normierungen

    Directory of Open Access Journals (Sweden)

    Christian Swertz

    2013-03-01

    der Ausgabe 1/2013 wird dabei im Sinne der ersten dieser Fragen von Anja Klimsa eröffnet, die den Problembereich der Prävention in der Medienpädagogik vor Augen führt und dabei mit allem Nachdruck betont, dass heute nicht mehr der zu normierende, zu kontrollierende und mit Mängeln belastete Mensch im Mittelpunkt der Pädagogik steht, sondern die aktiven, emanzipierten und mündigen KompetenzträgerInnen. Angesichts der Unverbindlichkeit von Normenstandards hebt Klimsa so hervor, dass in der Trias von technologischer, normativer und handlungsorientierter Medienpädagogik einzig die letztere Möglichkeiten bietet, den Anforderungen der Medienprävention zu genügen. Denn nur jene medienpädagogischen Angebote, die im Sinne eines praxeologischen Empowerments die Teilnehmenden als bewusst handelnde AkteurInnen begreifen, die selbst ihren Raum gestalten, ihre Ziele setzen und ihre eigenen Handlungen auch bewerten, lassen sich als sinnvolle präventive Medienpädagogik umsetzen. Damit rücken die RezipientInnen – auch im Unterrichtsraum – ins Zentrum von Theorie und Praxis und können so im Sinne aktiver und partizipativer Medienarbeit eingebunden werden. Inwiefern mithin die handlungsorientierte Medienpädagogik jenseits der normativen Medienpädagogik zu einer didaktischen Norm werden könnte, bleibt zu diskutieren.Norm Friesen untersucht dann in seinem Beitrag unterschiedliche Normierungen und Modellierungen der Sozial- und Kulturtechniken des Sprechens und Schreibens bzw. der Sprache und der Schrift, die (historisch vor allem in zwei Paradigmen erschienen sind: im rationalistischen (universalistischen und schriftzentrierten Modell, dass von Descartes bis Chomsky wirksam war und ist, und im romantischen (am Ausdruck und dem Sprechen orientierten Modell, dass wir vor allem mit Rousseau verbinden. Friesen beschreibt dabei alte und neue Mythologien der Schrift und hebt u. a. hervor, dass alle monotheistischen Religionen (Islam, Judentum, Christentum das orale Wort

  18. PERFORMANCE DETERIORATION OF THERMOSIPHON SOLAR FLAT PLATE WATER HEATER DUE TO SCALING

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    arunachala umesh chandavar

    2011-12-01

    Full Text Available 0 0 1 340 1943 International Islamic University 16 4 2279 14.0 Normal 0 false false false EN-US JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Times New Roman";} The performance of Flat plate Solar Water Heater deteriorates within five to twelve years of their installation due to factors related to manufacturing, operating conditions, lack of maintenance etc. Especially, problem due to scaling is significant as it is based on quality of water used. The remaining factors are system dependent and could be overcome by quality production. Software is developed by incorporating Hottel Whillier Bliss (H-W-B equation to ascertain the effect of scaling on system efficiency in case of thermosiphon system. In case of clean thermosiphon system, the instantaneous efficiency calculated at 1000 W/m2 radiation is 72 % and it drops to 46 % for 3.7 mm scale thickness. The mass flow rate is reduced by 90 % for 3.7 mm scale thickness. Whereas, the average temperature drop of water in the tank is not critical due to considerable heat content in water under severe scaled condition.  But practically in case of major scale growth, some of the risers are likely to get blocked completely which leads to negligible temperature rise in the tank. ABSTRAK: Prestasi plat rata pemanas air suria merosot selepas lima hingga dua belas tahun  pemasangannya disebabkan faktor-faktor yang berkaitan dengan pembuatannya, cara kendaliannya, kurangnya penyelenggaraan dan sebagainya.  Terutama sekali, masalah disebabkan scaling (tembunan endapan mineral perlu diambil berat kerana ianya bergantung kepada kualiti air yang digunakan. Faktor-faktor selebihya bersandarkan sistem dan ia

  19. Basis set expansion for inverse problems in plasma diagnostic analysis

    Science.gov (United States)

    Jones, B.; Ruiz, C. L.

    2013-07-01

    A basis set expansion method [V. Dribinski, A. Ossadtchi, V. A. Mandelshtam, and H. Reisler, Rev. Sci. Instrum. 73, 2634 (2002)], 10.1063/1.1482156 is applied to recover physical information about plasma radiation sources from instrument data, which has been forward transformed due to the nature of the measurement technique. This method provides a general approach for inverse problems, and we discuss two specific examples relevant to diagnosing fast z pinches on the 20-25 MA Z machine [M. E. Savage, L. F. Bennett, D. E. Bliss, W. T. Clark, R. S. Coats, J. M. Elizondo, K. R. LeChien, H. C. Harjes, J. M. Lehr, J. E. Maenchen, D. H. McDaniel, M. F. Pasik, T. D. Pointon, A. C. Owen, D. B. Seidel, D. L. Smith, B. S. Stoltzfus, K. W. Struve, W. A. Stygar, L. K. Warne, J. R. Woodworth, C. W. Mendel, K. R. Prestwich, R. W. Shoup, D. L. Johnson, J. P. Corley, K. C. Hodge, T. C. Wagoner, and P. E. Wakeland, in Proceedings of the Pulsed Power Plasma Sciences Conference (IEEE, 2007), p. 979]. First, Abel inversion of time-gated, self-emission x-ray images from a wire array implosion is studied. Second, we present an approach for unfolding neutron time-of-flight measurements from a deuterium gas puff z pinch to recover information about emission time history and energy distribution. Through these examples, we discuss how noise in the measured data limits the practical resolution of the inversion, and how the method handles discontinuities in the source function and artifacts in the projected image. We add to the method a propagation of errors calculation for estimating uncertainties in the inverted solution.

  20. Alterations of consciousness and mystical-type experiences after acute LSD in humans.

    Science.gov (United States)

    Liechti, Matthias E; Dolder, Patrick C; Schmid, Yasmin

    2017-05-01

    Lysergic acid diethylamide (LSD) is used recreationally and in clinical research. Acute mystical-type experiences that are acutely induced by hallucinogens are thought to contribute to their potential therapeutic effects. However, no data have been reported on LSD-induced mystical experiences and their relationship to alterations of consciousness. Additionally, LSD dose- and concentration-response functions with regard to alterations of consciousness are lacking. We conducted two placebo-controlled, double-blind, cross-over studies using oral administration of 100 and 200 μg LSD in 24 and 16 subjects, respectively. Acute effects of LSD were assessed using the 5 Dimensions of Altered States of Consciousness (5D-ASC) scale after both doses and the Mystical Experience Questionnaire (MEQ) after 200 μg. On the MEQ, 200 μg LSD induced mystical experiences that were comparable to those in patients who underwent LSD-assisted psychotherapy but were fewer than those reported for psilocybin in healthy subjects or patients. On the 5D-ASC scale, LSD produced higher ratings of blissful state, insightfulness, and changed meaning of percepts after 200 μg compared with 100 μg. Plasma levels of LSD were not positively correlated with its effects, with the exception of ego dissolution at 100 μg. Mystical-type experiences were infrequent after LSD, possibly because of the set and setting used in the present study. LSD may produce greater or different alterations of consciousness at 200 μg (i.e., a dose that is currently used in psychotherapy in Switzerland) compared with 100 μg (i.e., a dose used in imaging studies). Ego dissolution may reflect plasma levels of LSD, whereas more robustly induced effects of LSD may not result in such associations.

  1. LSD Increases Primary Process Thinking via Serotonin 2A Receptor Activation

    Science.gov (United States)

    Kraehenmann, Rainer; Pokorny, Dan; Aicher, Helena; Preller, Katrin H.; Pokorny, Thomas; Bosch, Oliver G.; Seifritz, Erich; Vollenweider, Franz X.

    2017-01-01

    Rationale: Stimulation of serotonin 2A (5-HT2A) receptors by lysergic acid diethylamide (LSD) and related compounds such as psilocybin has previously been shown to increase primary process thinking – an ontologically and evolutionary early, implicit, associative, and automatic mode of thinking which is typically occurring during altered states of consciousness such as dreaming. However, it is still largely unknown whether LSD induces primary process thinking under placebo-controlled, standardized experimental conditions and whether these effects are related to subjective experience and 5-HT2A receptor activation. Therefore, this study aimed to test the hypotheses that LSD increases primary process thinking and that primary process thinking depends on 5-HT2A receptor activation and is related to subjective drug effects. Methods: Twenty-five healthy subjects performed an audio-recorded mental imagery task 7 h after drug administration during three drug conditions: placebo, LSD (100 mcg orally) and LSD together with the 5-HT2A receptor antagonist ketanserin (40 mg orally). The main outcome variable in this study was primary index (PI), a formal measure of primary process thinking in the imagery reports. State of consciousness was evaluated using the Altered State of Consciousness (5D-ASC) rating scale. Results: LSD, compared with placebo, significantly increased primary index (p LSD-induced increase in primary index was positively correlated with LSD-induced disembodiment (p LSD-induced increases in primary index and changes in state of consciousness were fully blocked by ketanserin. Conclusion: LSD induces primary process thinking via activation of 5-HT2A receptors and in relation to disembodiment and blissful state. Primary process thinking appears to crucially organize inner experiences during both dreams and psychedelic states of consciousness. PMID:29167644

  2. Updating the lamellar hypothesis of hippocampal organization

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    Robert S Sloviter

    2012-12-01

    Full Text Available In 1971, Andersen and colleagues proposed that excitatory activity in the entorhinal cortex propagates topographically to the dentate gyrus, and on through a trisynaptic circuit lying within transverse hippocampal slices or lamellae [Andersen, Bliss, and Skrede. 1971. Lamellar organization of hippocampal pathways. Exp Brain Res 13, 222-238]. In this way, a relatively simple structure might mediate complex functions in a manner analogous to the way independent piano keys can produce a nearly infinite variety of unique outputs. The lamellar hypothesis derives primary support from the lamellar distribution of dentate granule cell axons (the mossy fibers, which innervate dentate hilar neurons and area CA3 pyramidal cells and interneurons within the confines of a thin transverse hippocampal segment. Following the initial formulation of the lamellar hypothesis, anatomical studies revealed that unlike granule cells, hilar mossy cells, CA3 pyramidal cells, and Layer II entorhinal cells all form axonal projections that are more divergent along the longitudinal axis than the clearly lamellar mossy fiber pathway. The existence of pathways with translamellar distribution patterns has been interpreted, incorrectly in our view, as justifying outright rejection of the lamellar hypothesis [Amaral and Witter. 1989. The three-dimensional organization of the hippocampal formation: a review of anatomical data. Neuroscience 31, 571-591]. We suggest that the functional implications of longitudinally-projecting axons depend not on whether they exist, but on what they do. The observation that focal granule cell layer discharges normally inhibit, rather than excite, distant granule cells suggests that longitudinal axons in the dentate gyrus may mediate "lateral" inhibition and define lamellar function, rather than undermine it. In this review, we attempt a reconsideration of the evidence that most directly impacts the physiological concept of hippocampal lamellar

  3. Reaching the hard-to-reach.

    Science.gov (United States)

    Valdes, C

    1992-01-01

    Guatemala's family planning (FP) programs are innovative but contraceptive use is only 23%. Total fertility is 5.3 children/woman, and the 9.5 million population will double in 23 years. The problem is poverty and illiteracy among rural residents removed from health services. 80% live in poverty and 80% are illiterate. Government effort is devoted to combating diseases such as diarrhea so there are few funds for implementing a comprehensive population policy. There is support within the national government but FP lacks priority status. APROFAM's goals are to use innovative marketing methods to inform the rural population who lack access to and knowledge about FP. Service delivery is constrained by the difficulty in reaching remote areas where 4 out of 10 indigenous Guatemalans live. Infant mortality can reach as high as 200/1000 live births. Population growth has slowed, and APROFAM plans to reach 16,000 more in the future. Promotions are conducted in several languages and aired on radio, television, and in the print media. It has been found that market research is the most effective strategy in reaching indigenous families. APROFAM has also been effective in upgrading service facilities through training, client surveys, and setting improved clinic standards. Breastfeeding, training, and voluntary sterilization programs contribute to the primary care effort. The example is given of Paulina Lebron from a very poor area who has learned how to space her children and thus improve the standard of living for her family. Eventually, she convinced herself and her family that sterilization was necessary, and now the couple enjoy the bliss of newlyweds without fear of pregnancy.

  4. The Energy Cascade Associated with the North Atlantic Oscillation

    Science.gov (United States)

    Castanheira, J. M.; Marques, C. A. F.

    2017-12-01

    The North Atlantic Oscillation or Arctic Oscillation (NAO/AO), in a more hemispheric expression, is the dominant mode of variability of the extratropical atmospheric circulation. In the literature which analyses the association of low frequency variability of the NAO/AO with other climate variables, it is very common to find the idea of circulation and climate impacts of the NAO/AO. It is usually suggested that the NAO influences the position of North Atlantic storm tracks and the related transport of heat and moisture. However, in spite of the long time since the NAO variability mode was uncovered (Walker and Bliss, 1932), its underlying dynamical mechanisms are not well understood yet. In fact, it is not yet consensual that the NAO influences the position of the storm tracks, being possible that the relationship is in the opposite way with the storm track activity influencing de NAO. In this communication we will present an analysis of anomalies of the energy cascade associated with the NAO. A detailed version of the Lorenz energy cycle, which decomposes the energy flows into baroclinic and barotropic terms and into zonal mean and eddy components, was applied to the 6-hourly ERA-I reanalysis for the period of 1979 to 2016. The obtained results show that the positive NAO phase is preceded by an significant increase of synoptic baroclinic eddy activity. The eddy available potential energy is converted into kinetic energy and transferred to barotropic synoptic eddies. Then, the kinetic energy is transferred upscale into the barotropic planetary waves, which reproduce the NAO pattern. Therefore, we conclude that the synoptic baroclinic eddy activity forces the NAO variability. No clear signal was found for a modulating role of the NAO in the baroclinic eddy activity.

  5. Basis set expansion for inverse problems in plasma diagnostic analysis

    Energy Technology Data Exchange (ETDEWEB)

    Jones, B.; Ruiz, C. L. [Sandia National Laboratories, PO Box 5800, Albuquerque, New Mexico 87185 (United States)

    2013-07-15

    A basis set expansion method [V. Dribinski, A. Ossadtchi, V. A. Mandelshtam, and H. Reisler, Rev. Sci. Instrum. 73, 2634 (2002)] is applied to recover physical information about plasma radiation sources from instrument data, which has been forward transformed due to the nature of the measurement technique. This method provides a general approach for inverse problems, and we discuss two specific examples relevant to diagnosing fast z pinches on the 20–25 MA Z machine [M. E. Savage, L. F. Bennett, D. E. Bliss, W. T. Clark, R. S. Coats, J. M. Elizondo, K. R. LeChien, H. C. Harjes, J. M. Lehr, J. E. Maenchen, D. H. McDaniel, M. F. Pasik, T. D. Pointon, A. C. Owen, D. B. Seidel, D. L. Smith, B. S. Stoltzfus, K. W. Struve, W. A. Stygar, L. K. Warne, J. R. Woodworth, C. W. Mendel, K. R. Prestwich, R. W. Shoup, D. L. Johnson, J. P. Corley, K. C. Hodge, T. C. Wagoner, and P. E. Wakeland, in Proceedings of the Pulsed Power Plasma Sciences Conference (IEEE, 2007), p. 979]. First, Abel inversion of time-gated, self-emission x-ray images from a wire array implosion is studied. Second, we present an approach for unfolding neutron time-of-flight measurements from a deuterium gas puff z pinch to recover information about emission time history and energy distribution. Through these examples, we discuss how noise in the measured data limits the practical resolution of the inversion, and how the method handles discontinuities in the source function and artifacts in the projected image. We add to the method a propagation of errors calculation for estimating uncertainties in the inverted solution.

  6. Pixel-Level Decorrelation and BiLinearly Interpolated Subpixel Sensitivity applied to WASP-29b

    Science.gov (United States)

    Challener, Ryan; Harrington, Joseph; Cubillos, Patricio; Blecic, Jasmina; Deming, Drake

    2017-10-01

    Measured exoplanet transit and eclipse depths can vary significantly depending on the methodology used, especially at the low S/N levels in Spitzer eclipses. BiLinearly Interpolated Subpixel Sensitivity (BLISS) models a physical, spatial effect, which is independent of any astrophysical effects. Pixel-Level Decorrelation (PLD) uses the relative variations in pixels near the target to correct for flux variations due to telescope motion. PLD is being widely applied to all Spitzer data without a thorough understanding of its behavior. It is a mathematical method derived from a Taylor expansion, and many of its parameters do not have a physical basis. PLD also relies heavily on binning the data to remove short time-scale variations, which can artifically smooth the data. We applied both methods to 4 eclipse observations of WASP-29b, a Saturn-sized planet, which was observed twice with the 3.6 µm and twice with the 4.5 µm channels of Spitzer's IRAC in 2010, 2011 and 2014 (programs 60003, 70084, and 10054, respectively). We compare the resulting eclipse depths and midpoints from each model, assess each method's ability to remove correlated noise, and discuss how to choose or combine the best data analysis methods. We also refined the orbit from eclipse timings, detecting a significant nonzero eccentricity, and we used our Bayesian Atmospheric Radiative Transfer (BART) code to retrieve the planet's atmosphere, which is consistent with a blackbody. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

  7. El Paso Formation - a Lower Ordovician platform carbonate deposit

    Energy Technology Data Exchange (ETDEWEB)

    Clemons, R.E.

    1987-05-01

    The eastward-transgressive Lower Ordovician El Paso Formation conformably overlies Bliss Sandstone in southern New Mexico. Locally, lower El Paso was deposited on low hills of plutonic and volcanic rocks. The region subsided gradually throughout Canadian time, receiving the El Paso carbonate rock blanket up to 460 m thick. Lithologic and chronologic correlative rocks were deposited over most of the southwestern US as the first Paleozoic carbonate platform sequence. The El Paso Formation contains four members, listed here in ascending order: Hitt Canyon, Jose, McKelligon, and Padre. Gradually decreasing sand content upward through the Hitt Canyon indicates deepening water and/or greater distance to shore. Girvanella(.) oncolites are locally abundant. Stromatolite mounds near the top of the Hitt Canyon, combined with an influx of sand, ooids, and rounded bioclasts in the Jose Member, recorded a shoaling phase. The overlying McKelligon Member contains little or no sand, and sponge-Calathium mounds are prominent at some locales. Stromatolite mounds are interbedded with sponge-Calathium mounds in a few sections. Lower Padre Member beds are typically silty to sandy and locally contain thinly-laminated zones. The Padre contains more restricted fauna that includes traces of ostracods. Pervasive bioturbation of El Paso beds and fauna consisting of echinoderms, sponges, gastropods, trilobites, Nuia, Calathium, cephalopods, and algae plus minor brachiopods and Pulchrilamina indicate predominating shallow-subtidal environments. Low-energy platform environments, in which a large volume of micritic muds accumulated, were disturbed thousands of times by storms producing abundant thin, poorly washed biosparite, intrasparite, and intrasparrudite lenses.

  8. The evolution of blood pressure and the rise of mankind.

    Science.gov (United States)

    Schulte, Kevin; Kunter, Uta; Moeller, Marcus J

    2015-05-01

    Why is it that only human beings continuously perform acts of heroism? Looking back at our evolutionary history can offer us some potentially useful insight. This review highlights some of the major steps in our evolution-more specifically, the evolution of high blood pressure. When we were fish, the first kidney was developed to create a standardized internal 'milieu' preserving the primordial sea within us. When we conquered land as amphibians, the evolution of the lung required a low systemic blood pressure, which explains why early land vertebrates (amphibians, reptiles) are such low performers. Gaining independence from water required the evolution of an impermeable skin and a water-retaining kidney. The latter was accomplished twice with two different solutions in the two major branches of vertebrate evolution: mammals excrete nitrogenous waste products as urea, which can be utilized by the kidney as an osmotic agent to produce more concentrated urine. Dinosaurs and birds have a distinct nitrogen metabolism and excrete nitrogen as water-insoluble uric acid-therefore, their kidneys cannot use urea to concentrate as well. Instead, some birds have developed the capability to reabsorb water from their cloacae. The convergent development of a separate small circulation of the lung in mammals and birds allowed for the evolution of 'high blood-pressure animals' with better capillarization of the peripheral tissues allowing high endurance performance. Finally, we investigate why mankind outperforms any other mammal on earth and why, to this day, we continue to perform acts of heroism on our eternal quest for personal bliss. © The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

  9. Assessment of the Economic Impact of Belimumab for the Treatment of Systemic Lupus Erythematosus in the Italian Setting: A Cost-Effectiveness Analysis.

    Science.gov (United States)

    Pierotti, Francesca; Palla, Ilaria; Treur, Maarten; Pippo, Lara; Turchetti, Giuseppe

    2015-01-01

    The purpose of this analysis is to evaluate the cost-effectiveness of belimumab, a new biological treatment specifically developed for the treatment of Systemic Lupus Erythematosus (SLE), in the Italian setting. SLE is a chronic non-organ specific autoimmune disease characterized by a disregulation of the immune system that involves many organs and systems. A cost-effectiveness micro-simulation model with a lifetime horizon originally developed for the UK was adapted to the Italian setting. The analysis compared Standard of Care (SoC) alone vs belimumab plus SoC from a National Healthcare Service (NHS) and societal perspective. Health-economic consequences of treatments and organ damage progression were calculated. When available, Italian data were used, otherwise UK costs were converted using Purchasing Power Parities (PPPs). Utility values were based on the EQ-5D™ assessments in the belimumab clinical trials (BLISS 52 and 76). Results were discounted with 3% for costs and effects. A maximum belimumab treatment duration of 6 years was assumed and wastage costs were considered. Cost per life year gained (Incremental Cost-Effectiveness Ratio, ICER) and cost per Quality Adjusted Life Year (QALY) (Incremental Cost-Utility Ratio, ICUR) were €22,990 and €32,859, respectively. These values reduced to €20,119 and €28,754, respectively, when indirect costs were included. It may be concluded that in the Italian setting and according to the guidelines of the Italian Association of Health Economics (IAHE), belimumab was shown to be cost-effective, in terms of both ICER and ICUR, (€25-40,000/QALY).

  10. Assessment of the Economic Impact of Belimumab for the Treatment of Systemic Lupus Erythematosus in the Italian Setting: A Cost-Effectiveness Analysis.

    Directory of Open Access Journals (Sweden)

    Francesca Pierotti

    Full Text Available The purpose of this analysis is to evaluate the cost-effectiveness of belimumab, a new biological treatment specifically developed for the treatment of Systemic Lupus Erythematosus (SLE, in the Italian setting. SLE is a chronic non-organ specific autoimmune disease characterized by a disregulation of the immune system that involves many organs and systems.A cost-effectiveness micro-simulation model with a lifetime horizon originally developed for the UK was adapted to the Italian setting. The analysis compared Standard of Care (SoC alone vs belimumab plus SoC from a National Healthcare Service (NHS and societal perspective. Health-economic consequences of treatments and organ damage progression were calculated. When available, Italian data were used, otherwise UK costs were converted using Purchasing Power Parities (PPPs. Utility values were based on the EQ-5D™ assessments in the belimumab clinical trials (BLISS 52 and 76. Results were discounted with 3% for costs and effects. A maximum belimumab treatment duration of 6 years was assumed and wastage costs were considered.Cost per life year gained (Incremental Cost-Effectiveness Ratio, ICER and cost per Quality Adjusted Life Year (QALY (Incremental Cost-Utility Ratio, ICUR were €22,990 and €32,859, respectively. These values reduced to €20,119 and €28,754, respectively, when indirect costs were included.It may be concluded that in the Italian setting and according to the guidelines of the Italian Association of Health Economics (IAHE, belimumab was shown to be cost-effective, in terms of both ICER and ICUR, (€25-40,000/QALY.

  11. Synergistic co-targeting of prostate-specific membrane antigen and androgen receptor in prostate cancer.

    Science.gov (United States)

    Murga, Jose D; Moorji, Sameer M; Han, Amy Q; Magargal, Wells W; DiPippo, Vincent A; Olson, William C

    2015-02-15

    Antibody-drug conjugates (ADCs) are an emerging class of cancer therapies that have demonstrated favorable activity both as single agents and as components of combination regimens. Phase 2 testing of an ADC targeting prostate-specific membrane antigen (PSMA) in advanced prostate cancer has shown antitumor activity. The present study examined PSMA ADC used in combination with potent antiandrogens (enzalutamide and abiraterone) and other compounds. Antiproliferative activity and expression of PSMA, prostate-specific antigen and androgen receptor were evaluated in the prostate cancer cell lines LNCaP and C4-2. Cells were tested for susceptibility to antiandrogens or other inhibitors, used alone and in combination with PSMA ADC. Potential drug synergy or antagonism was evaluated using the Bliss independence method. Enzalutamide and abiraterone demonstrated robust, statistically significant synergy when combined with PSMA ADC. Largely additive activity was observed between the antiandrogens and the individual components of the ADC (free drug and unmodified antibody). Rapamycin also synergized with PSMA ADC in certain settings. Synergy was linked in part to upregulation of PSMA expression. In androgen-dependent LNCaP cells, enzalutamide and abiraterone each inhibited proliferation, upregulated PSMA expression, and synergized with PSMA ADC. In androgen-independent C4-2 cells, enzalutamide and abiraterone showed no measurable antiproliferative activity on their own but increased PSMA expression and synergized with PSMA ADC nonetheless. PSMA expression increased progressively over 3 weeks with enzalutamide and returned to baseline levels 1 week after enzalutamide removal. The findings support exploration of clinical treatment regimens that combine potent antiandrogens and PSMA-targeted therapies for prostate cancer. © 2014 Wiley Periodicals, Inc.

  12. Selective Targeting of CTNBB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs.

    Directory of Open Access Journals (Sweden)

    Joost C M Uitdehaag

    Full Text Available The aim of combination drug treatment in cancer therapy is to improve response rate and to decrease the probability of the development of drug resistance. Preferably, drug combinations are synergistic rather than additive, and, ideally, drug combinations work synergistically only in cancer cells and not in non-malignant cells. We have developed a workflow to identify such targeted synergies, and applied this approach to selectively inhibit the proliferation of cell lines with mutations in genes that are difficult to modulate with small molecules. The approach is based on curve shift analysis, which we demonstrate is a more robust method of determining synergy than combination matrix screening with Bliss-scoring. We show that the MEK inhibitor trametinib is more synergistic in combination with the BRAF inhibitor dabrafenib than with vemurafenib, another BRAF inhibitor. In addition, we show that the combination of MEK and BRAF inhibitors is synergistic in BRAF-mutant melanoma cells, and additive or antagonistic in, respectively, BRAF-wild type melanoma cells and non-malignant fibroblasts. This combination exemplifies that synergistic action of drugs can depend on cancer genotype. Next, we used curve shift analysis to identify new drug combinations that specifically inhibit cancer cell proliferation driven by difficult-to-drug cancer genes. Combination studies were performed with compounds that as single agents showed preference for inhibition of cancer cells with mutations in either the CTNNB1 gene (coding for β-catenin, KRAS, or cancer cells expressing increased copy numbers of MYC. We demonstrate that the Wnt-pathway inhibitor ICG-001 and trametinib acted synergistically in Wnt-pathway-mutant cell lines. The ERBB2 inhibitor TAK-165 was synergistic with trametinib in KRAS-mutant cell lines. The EGFR/ERBB2 inhibitor neratinib acted synergistically with the spindle poison docetaxel and with the Aurora kinase inhibitor GSK-1070916 in cell lines

  13. Selective Targeting of CTNNB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs

    Science.gov (United States)

    Uitdehaag, Joost C. M.; de Roos, Jeroen A. D. M.; van Doornmalen, Antoon M.; Prinsen, Martine B. W.; Spijkers-Hagelstein, Jill A. P.; de Vetter, Judith R. F.; de Man, Jos; Buijsman, Rogier C.; Zaman, Guido J. R.

    2015-01-01

    The aim of combination drug treatment in cancer therapy is to improve response rate and to decrease the probability of the development of drug resistance. Preferably, drug combinations are synergistic rather than additive, and, ideally, drug combinations work synergistically only in cancer cells and not in non-malignant cells. We have developed a workflow to identify such targeted synergies, and applied this approach to selectively inhibit the proliferation of cell lines with mutations in genes that are difficult to modulate with small molecules. The approach is based on curve shift analysis, which we demonstrate is a more robust method of determining synergy than combination matrix screening with Bliss-scoring. We show that the MEK inhibitor trametinib is more synergistic in combination with the BRAF inhibitor dabrafenib than with vemurafenib, another BRAF inhibitor. In addition, we show that the combination of MEK and BRAF inhibitors is synergistic in BRAF-mutant melanoma cells, and additive or antagonistic in, respectively, BRAF-wild type melanoma cells and non-malignant fibroblasts. This combination exemplifies that synergistic action of drugs can depend on cancer genotype. Next, we used curve shift analysis to identify new drug combinations that specifically inhibit cancer cell proliferation driven by difficult-to-drug cancer genes. Combination studies were performed with compounds that as single agents showed preference for inhibition of cancer cells with mutations in either the CTNNB1 gene (coding for β-catenin), KRAS, or cancer cells expressing increased copy numbers of MYC. We demonstrate that the Wnt-pathway inhibitor ICG-001 and trametinib acted synergistically in Wnt-pathway-mutant cell lines. The ERBB2 inhibitor TAK-165 was synergistic with trametinib in KRAS-mutant cell lines. The EGFR/ERBB2 inhibitor neratinib acted synergistically with the spindle poison docetaxel and with the Aurora kinase inhibitor GSK-1070916 in cell lines with MYC amplification

  14. Eating with our eyes: From visual hunger to digital satiation.

    Science.gov (United States)

    Spence, Charles; Okajima, Katsunori; Cheok, Adrian David; Petit, Olivia; Michel, Charles

    2016-12-01

    One of the brain's key roles is to facilitate foraging and feeding. It is presumably no coincidence, then, that the mouth is situated close to the brain in most animal species. However, the environments in which our brains evolved were far less plentiful in terms of the availability of food resources (i.e., nutriments) than is the case for those of us living in the Western world today. The growing obesity crisis is but one of the signs that humankind is not doing such a great job in terms of optimizing the contemporary food landscape. While the blame here is often put at the doors of the global food companies - offering addictive foods, designed to hit 'the bliss point' in terms of the pleasurable ingredients (sugar, salt, fat, etc.), and the ease of access to calorie-rich foods - we wonder whether there aren't other implicit cues in our environments that might be triggering hunger more often than is perhaps good for us. Here, we take a closer look at the potential role of vision; Specifically, we question the impact that our increasing exposure to images of desirable foods (what is often labelled 'food porn', or 'gastroporn') via digital interfaces might be having, and ask whether it might not inadvertently be exacerbating our desire for food (what we call 'visual hunger'). We review the growing body of cognitive neuroscience research demonstrating the profound effect that viewing such images can have on neural activity, physiological and psychological responses, and visual attention, especially in the 'hungry' brain. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  15. Single and nested tungsten-wire-array dynamics and applications to inertial confinement fusion

    Science.gov (United States)

    Cuneo, Michael

    2005-10-01

    Wire array z-pinches show great promise as x-ray sources for indirect-drive inertial confinement fusion (ICF). The double z-pinch hohlraum, for example, has produced capsule radiation drive symmetric to within 3%. This ICF concept will require that each of two 20-mm-diam arrays scale to x-ray powers ˜1 PW, to drive high-yield (>0.2 GJ) capsules to ignition. High-yield fusion will also require a temporally shaped radiation pulse to drive a low-entropy capsule implosion. Recently, improved understanding of high current (11-19 MA) single and nested wire-array dynamics has enabled significant progress towards these goals. As at lower currents, a single wire array (and both the outer and inner arrays of a nested system) shows a wire ablation phase, axial modulation of the ablation rate, a larger ablation rate for larger diameter wires, trailing mass and trailing current. These processes and others produce a broad mass profile that may impact the optimization of x-ray output for single and nested arrays. Our new insights into wire array physics have led to 20-mm-diam single and nested arrays with peak powers of 150-190 TW at implosion times of 55-90 ns, increased from 60-120 TW at 95-110 ns, improving power scaling. Radiation pulse shapes required for 3-shock isentropic compression of high-yield ICF capsules have also been demonstrated with nested wire arrays operating in current-transfer mode. In collaboration with: D.B. Sinars, R.A. Vesey, E.M. Waisman, W.A. Stygar, D.E. Bliss, S.V. Lebedev, J.P. Chittenden, P.V. Sasorov, R.W. Lemke, E.P. Yu, B.B. Afeyan, G.R. Bennett, M.G. Mazarakis, M.R. Lopez, M.E. Savage, J.L. Porter, T.A. Mehlhorn.

  16. A theory of alpha/theta neurofeedback, creative performance enhancement, long distance functional connectivity and psychological integration.

    Science.gov (United States)

    Gruzelier, John

    2009-02-01

    Professionally significant enhancement of music and dance performance and mood has followed training with an EEG-neurofeedback protocol which increases the ratio of theta to alpha waves using auditory feedback with eyes closed. While originally the protocol was designed to induce hypnogogia, a state historically associated with creativity, the outcome was psychological integration, while subsequent applications focusing on raising the theta-alpha ratio, reduced depression and anxiety in alcoholism and resolved post traumatic stress syndrome (PTSD). In optimal performance studies we confirmed associations with creativity in musical performance, but effects also included technique and communication. We extended efficacy to dance and social anxiety. Diversity of outcome has a counterpart in wide ranging associations between theta oscillations and behaviour in cognitive and affective neuroscience: in animals with sensory-motor activity in exploration, effort, working memory, learning, retention and REM sleep; in man with meditative concentration, reduced anxiety and sympathetic autonomic activation, as well as task demands in virtual spatial navigation, focussed and sustained attention, working and recognition memory, and having implications for synaptic plasticity and long term potentiation. Neuroanatomical circuitry involves the ascending mescencephalic-cortical arousal system, and limbic circuits subserving cognitive as well as affective/motivational functions. Working memory and meditative bliss, representing cognitive and affective domains, respectively, involve coupling between frontal and posterior cortices, exemplify a role for theta and alpha waves in mediating the interaction between distal and widely distributed connections. It is posited that this mediation in part underpins the integrational attributes of alpha-theta training in optimal performance and psychotherapy, creative associations in hypnogogia, and enhancement of technical, communication and

  17. Nationalism and religion from the point of view of the philosophical heritage of Islam

    Directory of Open Access Journals (Sweden)

    Halilović Seid

    2015-01-01

    Full Text Available Division of people according to their different national and geographic features is not at all unnatural. However, in such divisions no group whatsoever can be especially prominent in the sense that it must necessarily be granted political power. The community which has sovereignty and political power in the Islamic cognitive tradition is called al-milla. Of course, al-milla here does not mean a nation, but a common path chosen by members of society in the light of intuitive and rational knowledge, which leads to the essences of ontological reality. Conversely, in the modern West, a nation draws on sensitive and emotional knowledge of folk bias and as such becomes a measure of political sovereignty. In fact, the nation is nowadays man's new social me, which in no way manifests sublime ontological realities, but creates reality itself. Therefore, in this paper we insist that nationalism is quite a new ideology of the modernistic era, which has never before in the history of human thought been credible. To show how a nation can be a measure and source of truth, values and rights, in this paper we use analyses of modern rationalist philosophers and German romantics. We will also explain that in the cognitive stage of Islam such an ideology must be clearly disproved. In religious traditions, kinship, financial and other material privileges are considered possible causes of the collapse of society. True privileges are only the nobility and purity of soul. The source of bliss, peace and harmony should be seen exactly in them and not in the national states that are the cause of conflicting identities, interests, territorial aspirations and suffering. Yet, many non-Western societies, including ours, are still in the race over who will be a more extreme supporter of the ideology of nationalism.

  18. Protolichesterinic acid enhances doxorubicin-induced apoptosis in HeLa cells in vitro.

    Science.gov (United States)

    Brisdelli, Fabrizia; Perilli, Mariagrazia; Sellitri, Doriana; Bellio, Pierangelo; Bozzi, Argante; Amicosante, Gianfranco; Nicoletti, Marcello; Piovano, Marisa; Celenza, Giuseppe

    2016-08-01

    The aim of this study was to investigate the effect of protolichesterinic acid, a lichen secondary metabolite, on anti-proliferative activity of doxorubicin in three human cancer cell lines, HeLa, SH-SY5Y and K562 cells. The data obtained from MTT assays, performed on cells treated with protolichesterinic acid and doxorubicin alone and in combination, were analysed by the median-effect method as proposed by Chou and Talalay and the Bliss independence model. Apoptosis rate was evaluated by fluorescence microscopy, caspase-3, 8 and 9 activities were detected by spectrofluorimetric analysis and protein expression of Bim, Bid, Bax and Mcl-2 was analysed by Western blotting. The interaction of protolichesterinic acid with thioesterase domain of human fatty acid synthase (hFAS) was investigated by a molecular docking study. The in vitro activity of doxorubicin against HeLa cancer cell line, but not against SH-SY5Y and K562 cells, was synergically increased by protolichesterinic acid. The increased cytotoxicity caused by protolichesterinic acid in HeLa cells was due to a pro-apoptotic effect and was associated to caspase-3, 8 and 9 activation. The simultaneous treatment for 24h with protolichesterinic acid plus doxorubicin caused an increase of Bim protein expression and the appearance of cleaved form of Bid protein. The molecular modelling analysis showed that protolichesterinic acid seemed to behave as a competitive inhibitor of hFAS. These results suggest that protolichesterinic acid could be envisaged as an useful tool against certain types of tumor cells in combination with anticancer drugs. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Mysticism, Meditation, and Monologue in Poemas del ser y del estar by Ernestina de Champourcin

    Directory of Open Access Journals (Sweden)

    Catherine G. Bellver

    2012-06-01

    Full Text Available Between 1954 and 1972, Ernestina de Champourcin wrote a series of six books centering on her poetic persona’s quest for God and expressions of love toward Him. Poemas del ser y el estar is in many ways the culmination of her religious phase not only because it is the last in the series, but also because in it she reaches the serenity acquired when the search for God is over and the soul can dwell in the blissful state of illumination. Many have found implications of mysticism in her religious poetry. However, in spite of the evidence of a goal of transcendence and signs of the purgative and illuminative phases essential to the mystic journey, Champourcin cannot be rightly called a mystic, for she does not realize or aspire to total dissolution of the self in perfect union with God. She does separate herself from the social and the literary reality around her, but she never entirely blocks out the world of experience nor forfeits her sense of self. She writes not as a saint, but as a woman poet with an overriding preoccupation with God. Her poetic speaker turns away from the crowd, the material world, and the ego-centered self in order to look inward at the world of the spirit where she can quietly address the divine other and enjoy the splendor of His presence. For her, a spiritual joy is achieved when “ser” and “estar” commingle in time and place, existence announces essence, and divine presence illuminates her.

  20. Translations of Poems by Yang Lian

    Directory of Open Access Journals (Sweden)

    Mabel Lee

    2007-01-01

    Full Text Available Biographical note on Yang Lian Yang Lian grew up in Beijing and began to establish his credentials as a poet from 1979. His early collections in China include Ritualisation of the Soul (1985, Desolate Soul (1986, Yellow (1989 and his long poem Yi that was first published under the title Sun and Man (1991. His poetry began to appear in English translations by John Minford, Sean Golden and Alisa Joyce in the Hong Kong translation magazine Renditions (1983 and 1985. He travelled to Australia in 1988, and then to New Zealand in 1989. After the June 4 events in Tiananmen Square, Beijing, he sought and obtained New Zealand citizenship. In 1991 he relocated to London where he now lives. His poems, essays and criticism have been collected in Yang Lian’s Works, 1982–1997 (1998 in two volumes and amounting to over 1000 pages, and in Yang Lian’s New Works, 1998-2002 (2003. Yang Lian’s major collections in English include: Masks and Crocodile (1990, The Dead in Exile (1990 and Yi (2002, translated by Mabel Lee; Non-Person Singular (1996, Where the Sea Stands Still (1999, Notes of a Blissful Ghost (2002, Concentric Circles (2005, translated by Brian Holton; and Unreal City: A Chinese Poet in Auckland (2006, translated by Jacob Edmond and Hilary Chung. Selections of his poems have been translated in over thirty languages, and have enabled him to travel regularly to literary festivals all over the world. In 1999 he won the Flaiano International Prize for Poetry.

  1. REPEATABILITY AND ACCURACY OF EXOPLANET ECLIPSE DEPTHS MEASURED WITH POST-CRYOGENIC SPITZER

    Energy Technology Data Exchange (ETDEWEB)

    Ingalls, James G.; Krick, J. E.; Carey, S. J.; Stauffer, John R.; Lowrance, Patrick J.; Grillmair, Carl J.; Capak, Peter; Glaccum, William; Laine, Seppo; Surace, Jason; Storrie-Lombardi, Lisa [Spitzer Science Center, California Institute of Technology, 1200 E California Boulevard, Mail Code 314-6, Pasadena, CA 91125 (United States); Buzasi, Derek [Department of Chemistry and Physics, Florida Gulf Coast University, Fort Myers, FL 33965 (United States); Deming, Drake [Department of Astronomy, University of Maryland, College Park, MD 20742-2421 (United States); Diamond-Lowe, Hannah; Stevenson, Kevin B. [Department of Astronomy and Astrophysics, University of Chicago, 5640 S Ellis Avenue, Chicago, IL 60637 (United States); Evans, Thomas M. [School of Physics, University of Exeter, EX4 4QL Exeter (United Kingdom); Morello, G. [Department of Physics and Astronomy, University College London, Gower Street, WC1 E6BT (United Kingdom); Wong, Ian, E-mail: ingalls@ipac.caltech.edu [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States)

    2016-08-01

    We examine the repeatability, reliability, and accuracy of differential exoplanet eclipse depth measurements made using the InfraRed Array Camera (IRAC) on the Spitzer Space Telescope during the post-cryogenic mission. We have re-analyzed an existing 4.5 μ m data set, consisting of 10 observations of the XO-3b system during secondary eclipse, using seven different techniques for removing correlated noise. We find that, on average, for a given technique, the eclipse depth estimate is repeatable from epoch to epoch to within 156 parts per million (ppm). Most techniques derive eclipse depths that do not vary by more than a factor 3 of the photon noise limit. All methods but one accurately assess their own errors: for these methods, the individual measurement uncertainties are comparable to the scatter in eclipse depths over the 10 epoch sample. To assess the accuracy of the techniques as well as to clarify the difference between instrumental and other sources of measurement error, we have also analyzed a simulated data set of 10 visits to XO-3b, for which the eclipse depth is known. We find that three of the methods (BLISS mapping, Pixel Level Decorrelation, and Independent Component Analysis) obtain results that are within three times the photon limit of the true eclipse depth. When averaged over the 10 epoch ensemble,  5 out of 7 techniques come within 60 ppm of the true value. Spitzer exoplanet data, if obtained following current best practices and reduced using methods such as those described here, can measure repeatable and accurate single eclipse depths, with close to photon-limited results.

  2. О возможных древних чешско-балтийских лексических связях

    Directory of Open Access Journals (Sweden)

    Иван Иванович Лучиц-Федорец

    2011-12-01

    Full Text Available ABOUT THE POSSIBLE ANCIENT CZECH-BALTIC LEXICAL CONNECTIONSSummaryThe paper deals with the ancient (up to the 13th century A. D. Czech–Baltic lexical correspondences. The West Balts are supposed to penetrate into Moravia and the territory of the middle Danube. Probably they were the Galinds, that at the turn of the two eras moved from South Prussia, their homeland, to the South and split into two branches in the territory of Volyn. Accord­ing to the data of onomastics and toponymies, one of the branches settled near the Czech–Polish boundary, another moved to Podmoskovye. Here follows the enumeratien of the Czech lexemes touched upon in the paper and having the Baltic (and some of them also Russian correspondences:Klábositi ‘to chat, to talk nonsense’, lebediti se ‘to be in bliss, luxuriate’, třměti ‘to reel’, baracht(a ‘chatter, babble’, klopýtati‘to stumble, to stagger along’, hárati se‘to heat (about cow’, harhule ‘growth on a tree, excrescence’, batoliti se ‘waddle’, šklebit ‘to light dimly’, kobrtati ‘to stumble’, drobiti ‘to feel feverish, to shiver’, rozblptati ‘to be boiled to pulp’, duznit ‘to bang one’s back’, obočí ‘eyebow’, duněti ‘to rattle’, žíně ‘a special rope for climbing to a beehive on a tree’, těpiti ‘to carry’, řije ‘period if heat of deers’.

  3. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    1994-01-01

    Leur. Hilversum: Verloren, 1992, 288 pp. - Jane A. Kusin, Brigit Obrist van Eeuwijk, Small but strong; Cultural context of (malnutrition among the Northern Kwanga (East Sepik province, Papua New Guinea. Basel: Wepf & Co. AG Verlag, Basler Beiträge zur ethnologie, Band 34, 1992, 283 pp. - J. Thomas Lindblad, Pasuk Phongpaichit, The new wave of Japanese investment in ASEAN. Singapore: Institute of Southeast Asian studies, 1990, 127 pp. - Niels Mulder, Louis Gabaude, Une herméneutique bouddhique contemporaine de Thaïlande; Buddhadasa Bhikku. Paris: École Francaise d’Extrême-Orient, 1988, vii + 692 pp. - Marleen Nolten, Vinson H. Sutlive. Jr., Female and male in Borneo; Contributions and challenges to gender studies. Borneo research council Monograph series, volume 1, not dated but probably published in 1991. - Ton Otto, G.W. Trompf, Melanesian Religion. Cambridge: Cambridge University Press, 1991, xi + 283 pp., including select bibliography and index. - IBM Dharma Palguna, Gordon D. Jensen, The Balinese people; A reinvestigation of character. Singapore-New York: Oxford University Press, 1992, 232 pp., Luh Ketut Suryani (eds. - Anton Ploeg, Jürg Schmid, Söhne des Krokodils; Männerhausrituale und initiation in Yensan, Zentral-Iatmul, East Sepik province, Papua New Guinea. Basel: ethnologisches seminar der Universitat und Musuem für Völkerkunde (Basler Beiträge zur ethnologie, band 36, 1992, xii + 321 pp., Christine Kocher Schmid (eds. - Raechelle Rubinstein, W. van der Molen, Javaans Schrift. (Semaian 8. Leiden: Vakgroep talen en culturen van Zuidoost-Azië en Oceanië, Rijksuniversiteit te Leiden, 1993. x + 129 pp. - Tine G. Ruiter, Arthur van Schaik, Colonial control and peasant resources in Java; Agricultural involution reconsidered. Amsterdam: Koninklijk Nederlands Aardrijkskundig Genootschap/Instituut voor Sociale geografie Universiteit van Amsterdam, 1986, 210 pp. - R. Schefold, Andrew Beatty, Society and exchange in Nias. Oxford: Clarendon press, (Oxford

  4. écrivain-e. Par-delà le genre – par-delà le corps ?

    Directory of Open Access Journals (Sweden)

    Cécile Chamayou-Kuhn

    2009-12-01

    Geschlechtsidentität. Ungeachtet der unterschiedlichen Prägungen ihrer Autorinnen und der verschiedenen literarischen Gattungen, denen sie angehören, verweisen die hier vorgestellten Texte auf dieselbe Problematik : Inwiefern gelingt es den weiblichen Schriftstellerfiguren bei Schlag und Jelinek, den eigenen „sprechenden Körper“ überhaupt zu „erfassen“? Um dieser Thematik auf den Grund zu gehen, beziehen wir uns hauptsächlich auf die von Judith Butler geübte Kritik an der Psychoanalyse lacanscher Prägung und auf die von ihr entworfene Theorie einer Körper- und Geschlechterkonstruktion als diskursive Praxis. Unter diesem Blickwinkel werden folgende thematische Schwerpunkte sichtbar : erstens eine Dialektik der „Un- Sichtbarkeit“ der schreibenden Frau, zweitens eine Materialisierung ihres Körpers und drittens eine subversive Praxis der Maskerade, die als Entlarvung unterwerfender Akte bei der Körper- und Schrift-Genese fungiert. Allgemein lässt sich dabei beobachten, dass den hier untersuchten Werken ein durchaus ähnliches Drama zugrunde liegt : das Drama des durch Sprache symbolisch besetzten Körpers. Der Schlag und Jelinek gemeinsame Impetus zeigt sich darin, dass ihre weiblichen Figuren unermüdlich darum kämpfen, sich der symbolischen Ordnung zu entziehen, indem sie die Kategorien des Begehrens, des biologischen Geschlechts (sex und der Geschlechtsindentität (gender infrage stellen.Während das Schreiben für Schlag zumindest potentiell eine Genesung von Krankheit bzw. Kränkung ermöglicht, bleibt jedoch bei Jelinek ein solcher Ausweg verschlossen : Ihre Schriftstellerinnen-Figuren geben sich letzten Endes einem Totentanz des Signifikanten hin.

  5. Book Reviews

    Directory of Open Access Journals (Sweden)

    Judith Nagata

    1986-04-01

    : Stichting Internationaal Instituut voor sociale geschiedenis, 1985, xxviii + 210 pp., Margreet Schrevel (eds. - Jan van der Putten, Slamet Modiwirjo, Panglipur Ati (ed. Johan Sarmo & Hein Vruggink, Uitgegeven door de afdeling cultuurstudies van het Ministerie van Volksmobilisatie en cultuur (Suriname, 1983. - Jan van der Putten, Saleman Siswowitono, Dongèng Kancil; Het verhaal van kantjil (ed. J.J. Sarmo & H.D. Vruggink, Een uitgave van de afdeling cultuur studies van het Ministerie van cultuur, Jeugd en Sport (Suriname, 1983. - Jan van der Putten, Pamin Asmawidjaja, Djoko miskin; De arme jongeling (ed. J.J. Sarmo & H.D. Vruggink, Een uitgave van de afdeling cultuur studies van het Ministerie van cultuur, jeugd en sport (Suriname, 1983. - Jan van der Putten, Johan J. Sarmo, Cikal; Kalawarti Jawa-Suriname, Wonny Karijopawiro (redactie, Nummers 1 tot en met 4 (1: 1982; 2: mei 1983; 3: oktober 1983; 4: maart 1984., Sari Kasanpawiro, Hein Vruggink (eds. - S.C. van Randwijck, Th. van den End, De Gereformeerde Zendingsbond (1901-1961 Nederland-Tanah Toraja, een bronnenpublicatie, bewerkt door Dr. Th. van den End, 782 pp., 1985. - R. Roolvink, Judith Nagata, The reflowering of Malaysian Islam - Modern religious radicals and their roots, University of Columbia Press, Vancouver, 1984, xxv + 267 pp., 2 appendixes, index. - Roger Tol, Soenjono Dardjowidjojo, Vocabulary building in Indonesian: an advanced reader. Ohio University, Monographs in international studies, Southeast Asia series No. 64, 1984. XVII, 647 pp. - R.S. Wassing, Annegret Haake, Javanische Batik. Methode, Symbolik, Geschichte (Javanese Batik. Method, symbolism, history, Hannover: Verlag M. + H. Schaper (Textilkunst-Fach-schrifte, 1984. Bound, 128 pp., 24 colour ills., black and white ills., drawings. - R.S. Wassing, Inger McCabe Elliott, Batik. Fabled cloth of Java, New York: Clarkson N. Potter Inc., 1984. Bound, 240 pp., 128 colour ills., black and white ills., drawings. - R.S. Wassing, Alit Veldhuisen

  6. PRODUCTION OF NEW BIOMASS/WASTE-CONTAINING SOLID FUELS

    Energy Technology Data Exchange (ETDEWEB)

    David J. Akers; Glenn A. Shirey; Zalman Zitron; Charles Q. Maney

    2001-04-20

    CQ Inc. and its team members (ALSTOM Power Inc., Bliss Industries, McFadden Machine Company, and industry advisors from coal-burning utilities, equipment manufacturers, and the pellet fuels industry) addressed the objectives of the Department of Energy and industry to produce economical, new solid fuels from coal, biomass, and waste materials that reduce emissions from coal-fired boilers. This project builds on the team's commercial experience in composite fuels for energy production. The electric utility industry is interested in the use of biomass and wastes as fuel to reduce both emissions and fuel costs. In addition to these benefits, utilities also recognize the business advantage of consuming the waste byproducts of customers both to retain customers and to improve the public image of the industry. Unfortunately, biomass and waste byproducts can be troublesome fuels because of low bulk density, high moisture content, variable composition, handling and feeding problems, and inadequate information about combustion and emissions characteristics. Current methods of co-firing biomass and wastes either use a separate fuel receiving, storage, and boiler feed system, or mass burn the biomass by simply mixing it with coal on the storage pile. For biomass or biomass-containing composite fuels to be extensively used in the U.S., especially in the steam market, a lower cost method of producing these fuels must be developed that includes both moisture reduction and pelletization or agglomeration for necessary fuel density and ease of handling. Further, this method of fuel production must be applicable to a variety of combinations of biomass, wastes, and coal; economically competitive with current fuels; and provide environmental benefits compared with coal. Notable accomplishments from the work performed in Phase I of this project include the development of three standard fuel formulations from mixtures of coal fines, biomass, and waste materials that can be used in

  7. High reliability low jitter 80 kV pulse generator

    International Nuclear Information System (INIS)

    Savage, Mark Edward; Stoltzfus, Brian Scott

    2009-01-01

    Switching can be considered to be the essence of pulsed power. Time accurate switch/trigger systems with low inductance are useful in many applications. This article describes a unique switch geometry coupled with a low-inductance capacitive energy store. The system provides a fast-rising high voltage pulse into a low impedance load. It can be challenging to generate high voltage (more than 50 kilovolts) into impedances less than 10 (Omega), from a low voltage control signal with a fast rise time and high temporal accuracy. The required power amplification is large, and is usually accomplished with multiple stages. The multiple stages can adversely affect the temporal accuracy and the reliability of the system. In the present application, a highly reliable and low jitter trigger generator was required for the Z pulsed-power facility [M. E. Savage, L. F. Bennett, D. E. Bliss, W. T. Clark, R. S. Coats,J. M. Elizondo, K. R. LeChien, H. C. Harjes, J. M. Lehr, J. E. Maenchen, D. H. McDaniel, M. F. Pasik, T. D. Pointon, A. C. Owen, D. B. Seidel, D. L. Smith, B. S. Stoltzfus, K.W. Struve, W.A. Stygar, L.K. Warne, and J. R. Woodworth, 2007 IEEE Pulsed Power Conference, Albuquerque, NM (IEEE, Piscataway, NJ, 2007), p. 979]. The large investment in each Z experiment demands low prefire probability and low jitter simultaneously. The system described here is based on a 100 kV DC-charged high-pressure spark gap, triggered with an ultraviolet laser. The system uses a single optical path for simultaneously triggering two parallel switches, allowing lower inductance and electrode erosion with a simple optical system. Performance of the system includes 6 ns output rise time into 5.6 (Omega), 550 ps one-sigma jitter measured from the 5 V trigger to the high voltage output, and misfire probability less than 10 -4 . The design of the system and some key measurements will be shown in the paper. We will discuss the design goals related to high reliability and low jitter. While

  8. The reduction of retinene1 to vitamina A1 in vitro.

    Science.gov (United States)

    WALD, G; HUBBARD, R

    1949-01-01

    In the surviving vertebrate retina the retinene(1) liberated by bleaching rhodopsin is converted quantitatively to vitamin A(1). Recent chemical studies have indicated that in this process the aldehyde group of retinene(1) is reduced to the primary alcohol group of vitamin A(1) (Morton; Wald). Some time ago we brought this reaction into a cell-free brei prepared from cattle retinas. The retinas were frozen, desiccated, ground, and exhaustively extracted with petroleum ether; the resulting powder, stirred in neutral buffer solution and exposed to light, converted its retinene(1) completely to vitamin A(1). Some time ago also we observed that fresh rhodopsin solutions exhibit a special type of fading in darkness following exposure to light, which is absent from the same solutions after aging. We have confirmed Bliss's identification of this reaction as the conversion of retinene(1) to vitamin A(1). The system which reduces retinene(1) is fractionated anatomically in the retinal rods. The outer segments of the rods, broken off from the underlying retinal tissue, are unable to convert their retinene(1) to vitamin A(1). In the presence of a water extract of crushed retina they do perform this conversion. On the other hand the retinal tissue from which a water extract was taken has lost this capacity. Such washed retinal tissue is reactivated by returning the washings to the solid material. The activating effect of retinal washings on isolated outer limbs or washed retina is duplicated by a boiled muscle juice. This in turn can be replaced by reduced cozymase (reduced coenzyme I; DPN-H(2)); or by a mixture of DPN and fructosediphosphate. The conversion of retinene(1) to vitamin A(1) is therefore a reduction in which two atoms of hydrogen are transferred to retinene(1) from reduced cozymase. It is assumed that this reaction is catalyzed by an apoenzyme, retinene(1) reductase, present in the rod outer limb. This process is coupled with a second system in the outer segment

  9. Considering ethics, aesthetics and the dignity of the individual.

    Science.gov (United States)

    Strebler, Aline; Valentin, Claude

    2014-03-01

    There are variations on vulnerability that are often based on opposing authorities. In his book Parcours de la reconnaissance, Paul Ricœur offers a reflection grounded in a survey from Aristotle to Levinas, with way stations in phenomenology, from Hegel to Husserl. He sketches the silhouette of capable man. In a reversal of thinking and positioning, weakness, which could be considered the hallmark of disability in all its forms, becomes a source of mutual wealth and an argument in favour of reciprocity and dialogue. Relying on clinical examples, we propose art as a mediator of the doctor-patient relationship, which in its present unique form forces us to question the dynamics of empathy. A. Strebler A FEW GRAMS OF GOLD IN AN INSECURE WORLD: Vulnerability has long gone hand in hand with precarity. It is disturbing in a world where all is 'comfort and beauty, calm and bliss.' Additionally, vulnerability is a type of wound and wounds are what knit the relationship between patient and care provider. Similarly disturbing is poverty: the pauper is "without": without work, without a home, without a legal residency permit, without money… Poverty is also a wound, and yet it may serve as a path to "truth," according to the philosopher Simone Weil. These two concepts, equally vulnerable, question man's finite nature, and may serve as an introduction to the art of living together. In the midst of this ambiguity, the word "art" stands out. It is a counter-power, a challenge to established authority and politico-economic forms of government; it is inessential, unclassifiable, ungraspable, unthinkable and cannot be evaluated. Art avenges the abyss of ambiguity. C. Valentin COMMON SUMMARY: This article, composed of two core pieces, was written for a common project leading to the creation of a university degree at Paris 5 University (chaired by Pr. Hervé): Ethics, Aesthetics and the Dignity of the Individual. Together, they serve as a forum for reflection and dialogue in which

  10. Improving activities of daily living for nursing home elder persons in Taiwan.

    Science.gov (United States)

    Chang, Su-Hsien; Wung, Shu-Fen; Crogan, Neva L

    2008-01-01

    Excess disability among nursing home elder persons can be prevented or remediated. Because of self-selected disuse and caregiver support of dependency, nursing home residents are likely to develop excess disability. No study was found to test a theory-based program aimed at improving elder persons' self-care abilities for Taiwanese nursing home elder persons who are at risk for developing excess disability. The purpose of this study was to test the effectiveness of a theory-based intervention program on self-care, specifically on activities of daily living (ADLs) performance among nursing home elder persons in Taiwan. A secondary aim was to determine the correlation between ADLs performance and three bliss concepts: life satisfaction, self-esteem, and motivation in health behavior. This study used a quasi-experimental, two-group, pretest-posttest design. Forty-two qualified participants were recruited from two nursing homes located in southern Taiwan and assigned to either the experimental group (n = 21) or the comparison group (n = 21). Participants in the experimental group received the Self-Care Self-Efficacy Enhancement Program (SCSEEP), and those in the comparison group received biweekly social visits for 6 weeks. Levels of ADLs performance were measured by Tappen's Refined ADL Assessment Scale. Life satisfaction was measured by Adams' Life Satisfaction Index A. Self-esteem was measured by Rosenberg's Self-Esteem Scale. Motivation in health behavior was measured by Cox's Health Self-Determinism Index. Elder persons receiving the SCSEEP had significant improvement in feeding, dressing, grooming, and washing activities. Self-esteem (p = .011) and life satisfaction (p = .033) but not motivation in health behavior (p = .282) were positively correlated with levels of ADLs performance. The SCSEEP provides a theory-based intervention model for Taiwanese nursing home elder persons aimed at improving ADLs performance. Further research with a larger sample size is

  11. The influence of propofol, remifentanil and lidocaine on the tone of human bronchial smooth muscle.

    Science.gov (United States)

    Rogliani, Paola; Calzetta, Luigino; Rendina, Erino A; Massullo, Domenico; Dauri, Mario; Rinaldi, Barbara; Capuano, Annalisa; Matera, Maria Gabriella

    2013-06-01

    Bronchoscopy is generally a safe procedure, but the induction of anaesthesia can induce bronchospasm. Consequently we investigated the influence of propofol, remifentanil and lidocaine on the tone of the human bronchial smooth muscle. The influence of propofol, remifentanil and lidocaine on the contractile response of human bronchial smooth muscle to electrical field stimulation (EFS) has been evaluated. The role of capsaicin-sensitive sensory nerves and of inducible nitric oxide synthase has also been assessed. Furthermore, the interaction between these three dugs has been measured by Bliss Independence (BI) theory. Statistical significance (P < 0.05) was assessed by Student's t test or ANOVA. Propofol (1.3 μg ml(-1)) and lidocaine (1 mg ml(-1)) reduced the baseline tone of bronchial rings (-14.45 ± 4.53% and -33.40 ± 1.07%, respectively, P < 0.05), whereas remifentanil had not such effect. Aminoguanidine prevented the relaxant effect of propofol. Propofol did not alter the bronchial contractile response to EFS following 30 min of treatment, whereas remifentanil enhanced the bronchial tension (133.83 ± 9.38%, control 101.93 ± 6.82%, P < 0.05 P < 0.05) and lidocaine completely abolished the contractility at 1 mg ml(-1) (P < 0.05). The desensitization of capsaicin-sensitive sensory nerves normalized the hyperresponsiveness induced by remifentanil (-26.77 ± 1.68%, P < 0.05). Significant BI antagonism (P < 0.001) was detected for propofol and lidocaine on the bronchial hyperresponsiveness induced by remifentanil. Propofol and remifentanil may be used safely for bronchoscopy, although remifentanil should be associated with propofol or lidocaine to prevent the potential opioid-mediated bronchospasm. Copyright © 2013 Elsevier Ltd. All rights reserved.

  12. Solide en Gedegen Onderwijs. Wiskunde- en natuurkunde onderwijsdiscussies in de jaren 1920 als monitor voor disciplinevorming

    Directory of Open Access Journals (Sweden)

    Marco Tompitak

    2015-10-01

    Full Text Available Solid, high quality education. Debates on mathematics and physics education in the 1920s as monitor of discipline formationDutch secondary education in mathematics and physics during the first decades of the twentieth century offers a showcase in the growing apart of both the respective academic and teaching disciplines in these two subjects. Although there was one faculty of science at the universities, and all secondary school teachers were trained there both in mathematics and physics, there was a distinct feeling among teachers and academics that the two fields had grown apart.We illustrate this by investigating discussions among mathematics and physics teachers on both content and didactics of the curriculum. Mathematics had a clearly defined curriculum since 1863, mainly consisting of algebra and axiomatic Euclidean geometry. Supported by the fact that mathematics was regarded as the blissful road to certain knowledge and wisdom, this curriculum was fitted for up to eight hours per week. The physics curriculum had grown more organically; at the start of the new school system in the 1860s, secondary education in physics played a marginal role and was therefore endowed with only a few weekly lessons. By the 1920s, however, academic physics was highly regarded, and secondary education had grown both in enrolment and in its goals. Secondary education aimed no longer mainly to the preparation of the middle classes for their social function: it had also become a way of preparing for an academic or technical study.It turns out that mathematicians had much to lose in these developments and, in recognizing this fact, they stuck the more to old paradigms. In contrast, physics teachers and their academic colleagues were much more inclined to see opportunities in the changing educational environment. This is noticeable by diverging ideas about what ‘high quality’ education should be. Although mathematics had an old and highly regarded tradition in

  13. The Activities and Attitudes of Armenian-Georgian Troops which Affected the Course of Kösedağ War

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    Mehmet ÖZMENLİ

    2014-12-01

    Full Text Available The events which occurred during the course of the War of Kösedağ at which the Seljuk Empire of Turkey met the armies under the command of the Mongolian Baycu Noyan are one of the major happenings to be examined in terms of their consequences, ever recorded in Turkish History. Prior to the war, the Seljuks of Turkey were traumatized because of internal rebellions. The Mongol Army gained an easy victory because of the incorrect decisions made Sultan Gıyaseddin Kaykhusraw II from the beginning of the war and of the negative roles of those involved in the war. Anatolia, which was like paradise and whose inhabitants experienced a kind of idyllic bliss and happiness under the administration of The Seljuks, was invaded by the Mongolian army, which advanced facing no resistance and caused mischief on the earth. The sources concerned indicate that the relationship between the Turks, the Armenians and the Georgians coincided with the entrance of the Seljuks into Anatolia. The Armenians, who lived under oppression and tyranny under the administration of the Byzantine Empire, met and viewed the Seljucks as their liberators. However, the Christians during the Crusades provoked and instigated both the Armenians and sometimes the Georgians against the Turks. The Armenians, who captured the Çukurova Region with the help of the Crusaders, established a barony here. During the reign of Alaeddin Keykubâd and İzzeddin Keykavus, the Sultans of the Seljuks of Turkey, the Seljuks made the Armenians subjected to them, but the Armenians did not keep their promise during the war of Kösedağ in 1243. The study focuses on the effects of the course of Armenian and Georgian forces, which played a role in the War of Kösedağ, upon the course of the war. The study also deals, in brief, with the role the statesmen of the Seljuks played in the defeat. Different historical sources written in such various languages as Arabic, Syrian, Armenian, Persian and Georgian on the

  14. Geochemical studies of the geothermal area East of the Jombo Hill intrusion Coast Province. Final report

    International Nuclear Information System (INIS)

    Tole, M.P.

    1985-09-01

    Geothermal resources in Kenya can be classified into two types; (i) High temperature geothermal resources, found within the Kenyan section of Rift Valley System, and (ii) Low temperature geothermal resources found outside the main Rift Valley System (figure 1). The high temperature geothermal resources have received first priority in research and development, and this has culminated in their exploitation at the Olkaria Geothermal Field which currently generates 45 MW of electricity, representing approximately 18% of Kenya's electricity requirements. Further research is directed at opening up electricity generating plants within the Rift Valley Geothermal Systems occuring between Lake Bogoria and Lake Magadi. The low temperature geothermal resources have received less attention in Kenya. In some countries, low temperature geothermal resources have been utilised for a number of domestic and commercial undertakings (table 1), among them (a) space heating (b) recreational baths (c) sugar refining. In china, low temperature (less than 90 o C) geothermal reservoirs have been used to provide energy for electrical generating plants (Reed and Bliss, 1983). An examination of the distribution of the low temperature geothermal sites in Kenya (figure 1) indicates that most of them could be easily utilised for one or more of the domestic and commercial activities mentioned above, by virtue of their location. In order that recommendations regarding the type of use that each of these hotsprings can be put to can be made, proper evaluation of each site must be made: in particular the underground hotwater temperatures as well as the extent of the geothermal field at each site must be evaluated. Geochemical studies provide the cheapest (most cost-effective) method of geothermal energy exploration. The purpose of this project was to determine the extent of the hot zone, as well as the underground reservoir temperatures in the geothermal field North East of the Jomo Hill intrusion

  15. Distanciamiento ilustrado en las argumentaciones deconstructoras de Rousseau

    Directory of Open Access Journals (Sweden)

    Francisco Javier Higuero

    2017-07-01

    Full Text Available En conformidad con lo explicado por Jean-Jacques Rousseau a lo largo de su producción filosófica, el estado ideal de la naturaleza no sólo se define como anterior a categorizaciones lingüísticas, sino que, hasta cierto punto, ha sido romantizado por diversos críticos, abocados a presentar las ideas de dicho pensador como marcadamente alejadas de la premisas y propuestas esgrimidas por el movimiento cultural de la Ilustración. Tal estado originario de la naturaleza se presta a ser considerado como pacífico, harmónico, vacío de envidia y prelingüístico o silencioso. En semejantes circunstancias, el habitante de tal entorno natural se aproximaba al mundo directamente y sin las fisuras producidas por elucubraciones culturales, provenientes de dictámenes civilizatorios. Sin embargo, la teoría de la voluntad general, defendida por Rousseau en El contrato social, desarrolla estrategias argumentativas dirigidas a superar el aislacionismo congénito al habitante del estado de la naturaleza, intentando deconstruir la dicotomía binaria que enfrentaba a la abstracta racionalidad ilustrada con la inmediatez de la experiencia primigenia. The ideal state of nature, as explained in Jean-Jacques Rousseau’s philosophical production, is not only defined as non-linguistic, but also has been, to certain extent, romanticized by many critics who present the ideas of this thinker as distant from the premises and proposals that the cultural movement that the Enlightenment defended. Such an primary state of nature was considered to be blissful, peaceful, harmonious, void of envy or jealously and prelinguistic or silent. Related to this circumstance, man’s natural view of the world was immediate and whole, unfractured by language and articulated words. However, when Rousseau presented in The Social Contract his theory of the General Will, he developed argumentative strategies directed to overcome the isolationist connotations of the state of nature and

  16. Nabokov's "Torpid Smoke"

    Directory of Open Access Journals (Sweden)

    Leona Toker

    1988-06-01

    Full Text Available Nabokov's short stories are polished self-contained works of art. However, like his novels and poems, they can be profitably read in the light of their place in his general canon. This place is determined by the time when each story was written and by the way in which other works enrich and elucidate the significance of its images. The short fiction of Nabokov's Berlin period has been regarded largely as akin to studies that a painter makes in preparation for a big picture. In some cases, however, the stories seem to serve as safety valves for the urgent material that had to be kept out of the novels in order not to interfere with their design. A case in point is the 1935 story "Torpid Smoke," written at the juncture of Invitation to a Beheading and The Gift . The plight of the protagonist of "Torpid Smoke" is a hybrid of the tendencies manifest in Cincinnatus of Invitation and Fyodor Godunov Cherdyntsev of The Gift : however, unlike Fyodor, this young poet gets no encouragement in his wish to devote himself to literature; unlike Cincinnatus, he cannot reject his environment with a clear conscience. His father, the major obstacle to his literary pursuits, is essentially decent, well-meaning, and pathetically human—a far cry from the obnoxious "parodies" that surround Cincinnatus. The young poet is trapped between the exquisite happiness that accompanies poetic experience and the price that he cannot achieve artistic self-isolation. In a sense, the story dramatizes the conflict between morality and "aesthetic bliss." The imagery of the story ostensibly serves to increase the density of a plausible setting. Actually, the imagery is also functional; it forms a network of parallels and nuances that point both to the genuineness of the young man's talent and to the possible reason for the "puerile" quality of his "perishable" production, viz., to the presences of unprocessed issues whose pressure prevents him from successfully capturing his poetic

  17. « L'île du soleil » : une parenthèse de temporalité insolite The « Island of the Sun »: an Unusual Temporal Digression

    Directory of Open Access Journals (Sweden)

    Hélène Fragaki

    2010-12-01

    Full Text Available Dans le livre II de sa Bibliothèque historique, Diodore de Sicile raconte comment Iambule a découvert une île heureuse lors d’un voyage à travers l’Arabie. Ce récit fabuleux, qui peut être défini comme un roman utopique au sens large du terme, est donc délibérément intégré dans une œuvre qui se veut historique. Sa version originale, attribuée à Iambule, remonte à l’époque hellénistique et ne peut être postérieure au milieu du Ier s. av. J.-C., date à laquelle la Bibliothèque historique a été rédigée. Au début du roman, une série d’aventures extraordinaires anime le temps et l’éclaire d’une lueur mystérieuse en faisant intervenir des intervalles déterminés par des chiffres symboliques. On est ainsi introduit à une dimension temporelle utopique, celle de l’île heureuse : immuable, continu et homogène, le temps n’est que le support d’activités constructives, répétitives et rigoureusement rythmées ; il est dépourvu de tout aspect angoissant ou ravageur et n’amène que la croissance et la prospérité, d’autant plus que la vie est excessivement longue et la mort dédramatisée. Cette parenthèse temporelle paisible, dont la clôture est également marquée par des durées symboliques, apparaît comme une réaction à un temps réel violemment agité. Toutefois, elle n’est pas aussi statique qu’il ne paraît à première vue, dans la mesure où elle s’insère dans le mouvement de la temporalité historique et où elle est accessible par le temps bien plus turbulent de l’aventure et du voyage.In volume 2 of his book Bibliotheca Historica, Diodorus of Sicily tells the story of Iamboulos who discovered a blissful island while traveling through Arabia. This fabulous story, which can be defined as a utopian novel in the broader sense of the term, is therefore deliberately incorporated into a book which is supposed to be historical. Its original version, attributed to Iamboulos, dates

  18. Habitat Evaluation Procedures (HEP) Report; Steigerwald Lake National Wildlife Refuge, Technical Report 2000-2001.

    Energy Technology Data Exchange (ETDEWEB)

    Allard, Donna

    2001-09-01

    Steigenvald Lake National Wildlife Refuge (NWR, refuge) was established as a result of the U. S. Army Corps of Engineers (COE) transferring ownership of the Stevenson tract located in the historic Steigerwald Lake site to the U.S. Fish and Wildlife Service (FWS, Service) for the mitigation of the fish and wildlife losses associated with the construction of a second powerhouse at the Bonneville Dam on the Columbia River and relocation of the town of North Bonneville (Public Law 98-396). The construction project was completed in 1983 and resulted in the loss of approximately 577 acres of habitat on the Washington shore of the Columbia River (USFWS, 1982). The COE determined that acquisition and development of the Steigenvald Lake area, along with other on-site project management actions, would meet their legal obligation to mitigate for these impacts (USCOE, 1985). Mitigation requirements included restoration and enhancement of this property to increase overall habitat diversity and productivity. From 1994 to 1999, 317 acres of additional lands, consisting of four tracts of contiguous land, were added to the original refuge with Bonneville Power Administration (BPA) funds provided through the Washington Wildlife Mitigation Agreement. These tracts comprised Straub (191 acres), James (90 acres), Burlington Northern (27 acres), and Bliss (9 acres). Refer to Figure 1. Under this Agreement, BPA budgeted $2,730,000 to the Service for 'the protection, mitigation, and enhancement of wildlife and wildlife habitat that was adversely affected by the construction of Federal hydroelectric dams on the Columbia River or its tributaries' in the state of Washington (BPA, 1993). Lands acquired for mitigation resulting from BPA actions are evaluated using the habitat evaluation procedures (HEP) methodology, which quantifies how many Habitat Units (HUs) are to be credited to BPA. HUs or credits gained lessen BPA's debt, which was formally tabulated in the Federal Columbia

  19. Quality assessment of some selected brands of anti malarial drugs used in Ghana: A case study of Agona West Municipality

    International Nuclear Information System (INIS)

    Asare, Aquisman Ebenezer

    2016-07-01

    The availability of numerous brands of artesunate in our drug market today places clinicians and pharmacists in a difficult situation of choice of a suitable brand or the possibility of alternative use. Fake artesunate could compromise the hope that ACT (artemisinin combination therapy) offers for malaria control in Africa. In this study, quality of some selected brands of anti - malarial drugs used in the communities of Agona west Municipality, Ghana was determined. Blister or packs of anti – malarial tablets were randomly sampled. The Protocols of the International Pharmacopeia and Global Pharma Health Fund Minilab were used to assess the quality of anti – malarial tablets per blister pack manufactured by Bliss Gvs Pharma Ltd. India, Letap Pharmaceutical Company Ltd. Ghana and Guilin Pharmaceutical Company Ltd. China and sold in chemical sales outlets at the farming communities of Agona West Municipality, Ghana. The identification test was used to confirm the presence of active ingredients in the tablets. A confirmatory test for the active ingredient was achieved with artesunate (ICRS 1302) reference standards and Gsunate reference standard (ICRS4061). The friability test was used to confirm the hardness of the tablets to determine the drug ability to withstand abrasion in packaging, handling and shipping. The disintegration test was used to confirm the time required for the tablets to disintegrate into particles. Titrimetric analysis confirmed the amount of artesunate found in tablets.The results of the study are as follows for Artesunate by GPCL, LPL and Gsunate by BGPL; the identification test confirmed the presence of the active ingredient in all the brands. Based on the International Pharmacopoeia acceptable range of 1 to 15 min for genuine artesunate per tablet, 93.75 % of field selected artesunate blister pack tablets manufactured by GPCL passed the disintegration test and 6.25% failed. Also 85.57% of the sampled artesunate blister pack manufactured by

  20. Féerie pour un scandale : l’art et la morale dans Lolita (1958 de Vladimir Nabokov On the poetical uses of moral outrage in Lolita (1958 by Vladimir Nabokov

    Directory of Open Access Journals (Sweden)

    Jacques Sohier

    2010-02-01

    Full Text Available L’apothéose morale du personnage narrateur Humbert Humbert consiste en une mise en récit d’actes transgressifs, la pédophilie et l’inceste. Comment réconcilier l’art et la morale ? Dans la préface de Lolita, V. Nabokov pose, par l’entremise du préfacier fictif John Ray, un regard ambigu où le moralisme et le scientisme du clinicien s’entremêlent. Dans la postface rédigée par V. Nabokov, l’auteur revendique ouvertement ses choix esthétiques et affirme que Lolita n’est pas porté par une intention morale. La lecture détaillée de la postface révèle un auteur en butte au scandale qui éclate. Les choix poétiques sont donc explicités. La jouissance esthétique propre à l’art transcende ainsi le moralisme. V. Nabokov fait montre d’un formalisme rigoureux qui met en avant la pureté de l’art et son hétéronomie. Un mouvement dialectique fait vaciller les assises morales du lecteur confronté à l’immoralité du texte. Les arguments spécieux du narrateur font de Lolita un chef-d’œuvre de casuistique. Lolita propose au lecteur une surmorale qui trouve à s’exercer dans le sanctuaire de l’art.The moral apotheosis of the narrator-character Humbert Humbert consists in the narrative of transgressive acts like pedophilia and incest. How is it possible for the writer first, and then the reader, to reconcile art and morality? In the preface to Lolita, V. Nabokov impersonates the fictive John Ray and looks at transgression with both a moral and clinical intent. In the postface to the novel written by V. Nabokov himself, the writer affirms his aesthetics and claims that his novel has no moral in tow. A close reading of this preface shows a writer on the defensive in the face of a persisting scandal. Poetical options are carefully explained to the reader. Thus aesthetic bliss comes foremost transcending moralism. Nabokov shows himself a rigorous formalist insisting on the purity of art and its disconnection from

  1. High reliability low jitter 80 kV pulse generator

    Directory of Open Access Journals (Sweden)

    M. E. Savage

    2009-08-01

    Full Text Available Switching can be considered to be the essence of pulsed power. Time accurate switch/trigger systems with low inductance are useful in many applications. This article describes a unique switch geometry coupled with a low-inductance capacitive energy store. The system provides a fast-rising high voltage pulse into a low impedance load. It can be challenging to generate high voltage (more than 50 kilovolts into impedances less than 10  Ω, from a low voltage control signal with a fast rise time and high temporal accuracy. The required power amplification is large, and is usually accomplished with multiple stages. The multiple stages can adversely affect the temporal accuracy and the reliability of the system. In the present application, a highly reliable and low jitter trigger generator was required for the Z pulsed-power facility [M. E. Savage, L. F. Bennett, D. E. Bliss, W. T. Clark, R. S. Coats,J. M. Elizondo, K. R. LeChien, H. C. Harjes, J. M. Lehr, J. E. Maenchen, D. H. McDaniel, M. F. Pasik, T. D. Pointon, A. C. Owen, D. B. Seidel, D. L. Smith, B. S. Stoltzfus, K. W. Struve, W. A. Stygar, L. K. Warne, and J. R. Woodworth, 2007 IEEE Pulsed Power Conference, Albuquerque, NM (IEEE, Piscataway, NJ, 2007, p. 979]. The large investment in each Z experiment demands low prefire probability and low jitter simultaneously. The system described here is based on a 100 kV DC-charged high-pressure spark gap, triggered with an ultraviolet laser. The system uses a single optical path for simultaneously triggering two parallel switches, allowing lower inductance and electrode erosion with a simple optical system. Performance of the system includes 6 ns output rise time into 5.6  Ω, 550 ps one-sigma jitter measured from the 5 V trigger to the high voltage output, and misfire probability less than 10^{-4}. The design of the system and some key measurements will be shown in the paper. We will discuss the

  2. A new vision for the science of human flavor perception

    Directory of Open Access Journals (Sweden)

    Gordon M Shepherd

    2014-07-01

    -caloric-density foods. The fact that these products are themselves the results of scientific experiments to determine the "bliss points" of flavor underlines how important it is for academic scientists to inform consumers about flavor research, as in this conference. As basic scientists, our hope is that the public can become as well informed as the producers, so that all can work together to shape food products to be more healthy. The large audience, including many students, indicated the time is ripe for a concerted effort toward this goal. Finally, a panel of food activists, chaired by Peter Esmond and including three leading NYC chefs - Bill Telepan, Michael Nischan and Jeremy Bearman – described their efforts not only to create prestigious restaurants but also to deliver food to tens of thousands of school children over the past few years, using practical principles of making healthy food with attractive flavors.

  3. Bilimsel Toplantı Duyuruları

    Directory of Open Access Journals (Sweden)

    Adli Tıp Uzmanları Derneği ATUD

    1999-04-01

    Full Text Available 1\t51st Annual Meeting of the American Academy of Forensic Sciences (AAFS 15-\t20 February 1999, Orlando, Florida Information: AAFS, PO Box 669, Colorado Springs, CO 80904-00669, USA 2\tIl.Ulusal Hipertansiyon ve Böbrek Hastalıkları Kongresi 26-30 Nisan 1999, Antalya İletişim: Türk Hipertansiyon ve Böbrek Hastalıkları Derneği, Doç.Dr.Yunus Erdem, Hacettepe Üniv.Tıp Fakültesi Nefroloji BD. Sıhhiye-ANKARA Tel:324 31 09 3\tIII. Adli Bilimler Sempozyumu ’’Malpraktis” 6-7 Mayıs 1999, Erzurum, Atatürk Üniversitesi Tıp Fakültesi Adli Tıp AD İletişimAdli Tıp Uzmanları Derneği (ATUD, Dr. Nadir Arıcan, İ.Ü. İstanbul Tıp Fakültesi Adli Tıp AD 34390, Çapa, İstanbul Tel:0-212-6351179 4\tRoyal Society of Medicine AGM- Section of Clinical Forensic medicine and Legal Medicine. Sexual Assaults- a Multidisiplinary Approach 19\tJune 1999 Information: Louisa Bendela Tel: + 44 CO 171 290 2983/3904 Fax:+ 44 (0 171 290 2989 Email: louisa.bendela@roysocmed.ac.uk.or sections@roysocmed.ac.uk. or 5\t4th International GFS Conference on Forensic Handwriting and Document Examination. 23-\t26 June 1999,Hamburg, Germany Information: Dr.Peter E.Baier, GFS Secretary, Universitat Mannheim, Insitut fur Schrift und Uıkundenuntersuchung, D-68131 Mannheim /Germany Tel: + 49 621 292 8486 Fax:+ 49 621 292 8487 Email: PEBaier@aol.com 6\tForensic Science Society Summer Meeting 2-\t4 July 1999, College of Ripon and York St.John, York Tel: + 44 1423 506068 7\tAdli Hipnoz Konferansı ve Workshop 25-\t26 Ağustos 1999, İ.Ü.İstanbul Tıp Fakültesi 1933 Üniversitesi Reform Anfisi-İSTANBUL İletişim: Adli Tıp Uzmanları Derneği (ATUD, Uzm.Dr. Nevzat Alkan, İ.Ü.İstanbul Tıp Fakültesi Adli Tıp AD. Çapa-İSTANBUL Tel:0-212-635 11 79 8\tII. Stereolojik Metotlar ve Uygulamaları Kursu 25-\t27 Ağustos 1999, Samsun, 19 Mayıs Üniv. Tıp Fakültesi Anatomi AD. İletişim: Doç. Dr. Nihal İçten, 19 Mayıs Üniv. Tıp Fakültesi Anatomi AD

  4. Flower symbolism and the cult of relics in medieval Serbia

    Directory of Open Access Journals (Sweden)

    Popović Danica

    2008-01-01

    programmatic reestablishment of the cults of the Nemanjićs was predicated on theological and poetic models found in the medieval literary legacy. Similar developments are observable in the veneration of the Serbian saints north of the Sava and the Danube between the sixteenth and eighteenth centuries. The concept of a new lineage, that of the Brankovićs of Srem, of its flourishing and fruits, lay at the heart of the religio-political programme of the Metropolitanate of Krušedol, later of Karlovci, and was used as one of major historical arguments for the legitimacy of the Serbian presence in the region. A distinctive aspect of this theme is the materialization, conditionally speaking, of the concept of the blossoming, growth and enlivening of matter as a paradigm of the future resurrection and heavenly abodes. For understandable reasons, this was the central message communicated by Eastern Christian gravestones. Apart from other symbolical and allegorical signs, it was expressed by way of blooming lilies, flowers, foliate vines and fruits. This is observable in the funerary practice of medieval Serbia, too, but its distinctive feature, to judge from the surviving material, is in that this repertoire occurs in the form of a rounded-off programme on the representative tombs of the heads of the church. Particularly important of these are the marble sarcophagi at the Patriarchate of Pec with their semantically highly stratified ornamentation. The idea of resurrection and heavenly bliss is expressed through motifs such as arcades, blossoming crosses, rosette flowers, foliate vines, lilies etc. Given the symbolical nature and metaphorical and associative qualities of Byzantine funerary sculpture, there are good reasons to believe that this decoration in fact evoked texts such as Psalm 92, 12-14 about the future life of the righteous in the house of the Lord. It is in the light of these considerations that we should look at all aspects of the grave of archbishop Eustathios I and