WorldWideScience

Sample records for scandium 59

  1. Influence of scandium concentration on power generation figure of merit of scandium aluminum nitride thin films

    Energy Technology Data Exchange (ETDEWEB)

    Akiyama, Morito; Nagase, Toshimi [Measurement Solution Research Center, National Institute of Advanced Industrials Science and Technology, Tosu, Saga 841-0052 (Japan); Umeda, Keiichi; Honda, Atsushi [Murata Manufacturing Co., Ltd., Nagaokakyo, Kyoto 617-8555 (Japan)

    2013-01-14

    The authors have investigated the influence of scandium concentration on the power generation figure of merit (FOM) of scandium aluminum nitride (Sc{sub x}Al{sub 1-x}N) films prepared by cosputtering. The power generation FOM strongly depends on the scandium concentration. The FOM of Sc{sub 0.41}Al{sub 0.59}N film was 67 GPa, indicating that the FOM is five times larger than that of AlN. The FOM of Sc{sub 0.41}Al{sub 0.59}N film is higher than those of lead zirconate titanate and Pb(Mg{sub 1/3}Nb{sub 2/3})O{sub 3}-PbTiO{sub 3} films, which is the highest reported for any piezoelectric thin films. The high FOM of Sc{sub 0.41}Al{sub 0.59}N film is due to the high d{sub 31} and the low relative permittivity.

  2. Scandium recovery from slags after oxidized nickel ore processing

    Science.gov (United States)

    Smyshlyaev, Denis; Botalov, Maxim; Bunkov, Grigory; Rychkov, Vladimir; Kirillov, Evgeny; Kirillov, Sergey; Semenishchev, Vladimir

    2017-09-01

    One of the possible sources of scandium production - waste (slags) from processing of oxidized nickel ores, has been considered in present research work. The hydrometallurgical method has been selected as the primary for scandium extraction. Different reagents for leaching of scandium, such as sulfuric acid, various carbonate salts and fluorides, have been tested. Sulfuric acid has been recognized as an optimal leaching reagent. Sulfuric acid concentration of 100 g L-1 allowed recovering up to 97 % of scandium.

  3. Lifetime measurements and oscillator strengths in singly ionized scandium and the solar abundance of scandium

    Science.gov (United States)

    Pehlivan Rhodin, A.; Belmonte, M. T.; Engström, L.; Lundberg, H.; Nilsson, H.; Hartman, H.; Pickering, J. C.; Clear, C.; Quinet, P.; Fivet, V.; Palmeri, P.

    2017-12-01

    The lifetimes of 17 even-parity levels (3d5s, 3d4d, 3d6s and 4p2) in the region 57 743-77 837 cm-1 of singly ionized scandium (Sc II) were measured by two-step time-resolved laser induced fluorescence spectroscopy. Oscillator strengths of 57 lines from these highly excited upper levels were derived using a hollow cathode discharge lamp and a Fourier transform spectrometer. In addition, Hartree-Fock calculations where both the main relativistic and core-polarization effects were taken into account were carried out for both low- and high-excitation levels. There is a good agreement for most of the lines between our calculated branching fractions and the measurements of Lawler & Dakin in the region 9000-45 000 cm-1 for low excitation levels and with our measurements for high excitation levels in the region 23 500-63 100 cm-1. This, in turn, allowed us to combine the calculated branching fractions with the available experimental lifetimes to determine semi-empirical oscillator strengths for a set of 380 E1 transitions in Sc II. These oscillator strengths include the weak lines that were used previously to derive the solar abundance of scandium. The solar abundance of scandium is now estimated to logε⊙ = 3.04 ± 0.13 using these semi-empirical oscillator strengths to shift the values determined by Scott et al. The new estimated abundance value is in agreement with the meteoritic value (logεmet = 3.05 ± 0.02) of Lodders, Palme & Gail.

  4. Smelting of Scandium by Microwave Irradiation.

    Science.gov (United States)

    Fujii, Satoshi; Tsubaki, Shuntaro; Inazu, Naomi; Suzuki, Eiichi; Wada, Yuji

    2017-09-27

    Scandium is being explored as an alloying element for aluminum alloys, which are gaining importance as high-performance lightweight structural alloys in the transportation industry. A few years ago, Sc was also found to be suitable for use in electrical devices. High-Sc-content ScAlN thin films have attracted significant attention because of their strong piezoelectricity. The piezoelectric response of ScAlN suggests that ScAlN thin films formed on a hard substrate would be suitable surface acoustic wave wideband filters for next-generation wireless communication systems. However, it is often difficult to use ScAlN thin films in MEMS devices-including acoustic ones-because of the extremely high price of metallic Sc, given the difficulty associated with smelting it. Here, we propose a novel process for smelting Sc metal by microwave irradiation. Sc metal was able to be obtained successfully from ScF₃ through a microwave-irradiation-based carbon reduction reaction. The reaction temperature for this reduction process was approximately 880°C, which is half of that for the conventional smelting process involving reduction with Ca. Thus, the proposed microwave irradiation process has significant potential for use in the smelting of Sc metal.

  5. Smelting of Scandium by Microwave Irradiation

    Directory of Open Access Journals (Sweden)

    Satoshi Fujii

    2017-09-01

    Full Text Available Scandium is being explored as an alloying element for aluminum alloys, which are gaining importance as high-performance lightweight structural alloys in the transportation industry. A few years ago, Sc was also found to be suitable for use in electrical devices. High-Sc-content ScAlN thin films have attracted significant attention because of their strong piezoelectricity. The piezoelectric response of ScAlN suggests that ScAlN thin films formed on a hard substrate would be suitable surface acoustic wave wideband filters for next-generation wireless communication systems. However, it is often difficult to use ScAlN thin films in MEMS devices—including acoustic ones—because of the extremely high price of metallic Sc, given the difficulty associated with smelting it. Here, we propose a novel process for smelting Sc metal by microwave irradiation. Sc metal was able to be obtained successfully from ScF3 through a microwave-irradiation-based carbon reduction reaction. The reaction temperature for this reduction process was approximately 880°C, which is half of that for the conventional smelting process involving reduction with Ca. Thus, the proposed microwave irradiation process has significant potential for use in the smelting of Sc metal.

  6. Hydrometallurgical methods of recovery of scandium from the wastes of various technologies

    Science.gov (United States)

    Molchanova, T. V.; Akimova, I. D.; Smirnov, K. M.; Krylova, O. K.; Zharova, E. V.

    2017-03-01

    The recovery of scandium from the wastes of the production of uranium, titanium, iron-vanadium, and alumina is studied. The applied acid schemes of scandium transfer to a solution followed by ion-exchange recovery and extraction concentration of scandium ensure the precipitation of crude scandium oxides containing up to 5% Sc2O3. Scandium oxides of 99.96-99.99% purity are formed after additional refining of these crude oxides according to an extraction technology using a mixture 15% multiradical phosphine oxide or Cyanex-925 + 15% tributyl phosphate in kerosene.

  7. Synthesis and Reactivity of a Scandium Terminal Hydride: H2  Activation by a Scandium Terminal Imido Complex.

    Science.gov (United States)

    Han, Xianghao; Xiang, Li; Lamsfus, Carlos A; Mao, Weiqing; Lu, Erli; Maron, Laurent; Leng, Xuebing; Chen, Yaofeng

    2017-10-20

    Dihydrogen is easily activated by a scandium terminal imido complex containing the weakly coordinated THF. The reaction proceeds through a 1,2-addition mechanism, which is distinct from the σ-bond metathesis mechanism reported to date for rare-earth metal-mediated H2 activation. This reaction yields a scandium terminal hydride, which is structurally well-characterized, being the first one to date. The reactivity of this hydride is reported with unsaturated substrates, further shedding light on the existence of the terminal hydride complex. Interestingly, the H2 activation can be reversible. DFT investigations further eludciate the mechanistic aspects of the reactivity of the scandium anilido-terminal hydride complex with PhNCS but also on the reversible H2 activation process. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Thermoelectric material comprising scandium doped zinc cadmium oxide

    DEFF Research Database (Denmark)

    2016-01-01

    There is presented a composition of scandium doped Zinc Cadmium Oxide with the general formula ZnzCdxScyO which the inventors have prepared, and for which material the inventors have made the insight that it is particularly advantageous as an n-type oxide material, such as particularly advantageous...

  9. Scandium/carbon filters for soft x rays

    NARCIS (Netherlands)

    Artioukov, IA; Kasyanov, YS; Kopylets, IA; Pershin, YP; Romanova, SA

    2003-01-01

    This Note deals with thin-film soft x-ray filters for operation at the wavelengths near carbon K edge (similar to4.5 nm). The filters were fabricated by magnetron sputtering deposition of thin layers of scandium (total thickness 0.1-0.2 mum) onto films of polypropylene (thickness 1.5 mum) and

  10. Solvent extraction of scandium from lateritic nickel- cobalt ores using different organic reagents

    OpenAIRE

    Ferizoğlu Ece; Kaya Şerif; Topkaya Yavuz A.

    2016-01-01

    Scandium is the most important and strategic metal that can be recovered as a by-product from lateritic nickel-cobalt ores. In this research, different extractants were investigated in order to extract scandium from a sulfate medium by a using a solvent extraction method. Generally, the organic extractants are classified as acidic, neutral and basic organophosphorus compounds. However, in solvent extraction of scandium, the acidic and neutral organophosphorus compounds are preferred due to th...

  11. BASIC RESEARCH ON THE SEPARATION OF SCANDIUM YTTRIUM, AND THE RARE EARTHS BY SOLVENT EXTRACTION.

    Science.gov (United States)

    RARE EARTH ELEMENTS, * SOLVENT EXTRACTION ), (*CHELATE COMPOUNDS, RARE EARTH ELEMENTS), PURIFICATION, ATOMIC SPECTROSCOPY, SCANDIUM, YTTRIUM, PRASEODYMIUM, SAMARIUM, EUROPIUM, GADOLINIUM, TERBIUM, FLUORINE COMPOUNDS, KETONES

  12. Determination of scandium concentrate composition by WD-XRF and ICP-MS methods

    Science.gov (United States)

    Sarkisova, A. S.; Shibitko, A. O.; Abramov, A. V.; Rebrin, O. I.; Bunkov, G. M.; Lisienko, D. G.

    2017-09-01

    WD-XRF spectroscopy was applied for determining composition of scandium concentrate (ScC) containing 70 % scandium fluoride. Determination of ScC composition was performed using 6 glass beads reference materials produced by fusing synthesized mixture of analyte compounds with the lithium-borate flux in the ratio of 1:10. ScC powder with the known composition was then used as a powder pellet reference material to analyze scandium concentrate from technological line by external standard method. ICP-MS method was employed to control the ScC composition. The statistical data processing and metrological parameters evaluation of the analytical technique developed were carried out.

  13. Tin etching from metallic and oxidized scandium thin films

    Science.gov (United States)

    Pachecka, M.; Lee, C. J.; Sturm, J. M.; Bijkerk, F.

    2017-08-01

    The role of oxide on Sn adhesion to Sc surfaces was studied with in-situ ellipsometry, X-ray photoelectron spectroscopy and secondary electron microscopy. Sn etching with hydrogen radicals was performed on metallic Sc, metallic Sc with a native oxide, and a fully oxidized Sc layer. The results show that Sn adsorbs rather weakly to a non-oxidized Sc surface, and is etched relatively easily by atomic hydrogen. In contrast, the presence of native oxide on Sc allows Sn to adsorb more strongly to the surface, slowing the etching. Furthermore, thinner layers of scandium oxide result in weaker Sn adsorption, indicating that the layer beneath the oxide plays a significant role in determining the adsorption strength. Unexpectedly, for Sn on Sc2O3, and, to a lesser extent, for Sn on Sc, the etch rate shows a variation over time, which is explained by surface restructuring, temperature change, and hydrogen adsorption saturation.

  14. Tin etching from metallic and oxidized scandium thin films

    Directory of Open Access Journals (Sweden)

    M. Pachecka

    2017-08-01

    Full Text Available The role of oxide on Sn adhesion to Sc surfaces was studied with in-situ ellipsometry, X-ray photoelectron spectroscopy and secondary electron microscopy. Sn etching with hydrogen radicals was performed on metallic Sc, metallic Sc with a native oxide, and a fully oxidized Sc layer. The results show that Sn adsorbs rather weakly to a non-oxidized Sc surface, and is etched relatively easily by atomic hydrogen. In contrast, the presence of native oxide on Sc allows Sn to adsorb more strongly to the surface, slowing the etching. Furthermore, thinner layers of scandium oxide result in weaker Sn adsorption, indicating that the layer beneath the oxide plays a significant role in determining the adsorption strength. Unexpectedly, for Sn on Sc2O3, and, to a lesser extent, for Sn on Sc, the etch rate shows a variation over time, which is explained by surface restructuring, temperature change, and hydrogen adsorption saturation.

  15. Extraction of scandium by liquid di-2-ethylhexylphosphoric acid in fusible diluents

    Directory of Open Access Journals (Sweden)

    Ainur Isatayeva

    2015-03-01

    Full Text Available Currently widespread distribution of extraction methods using fusible reagents can be explained by a number of advantages, such as high kinetic characteristics of the process, the ease separation of two phases, high selectivity of many extractants, relatively complete regeneration. For the extraction of scandium in technological order, neutral and cation exchange extractants can be used. Several extraction reagents melt easily at high temperatures, and such melts can be used for extraction. Efficiency of the extraction of metal by cation reagents depends on many factors. Extraction of scandium by melt mixtures of di-2-ethylhexylphosphoric acid - higher carboxylic acid - paraffin and the effect of acidity of the aqueous phase, the concentration of scandium and the aqueous extractant in the organic phase, the volume ratio of organic and aqueous phases on the extraction of metal were studied. It was found that the extraction of scandium proceeds through the cation exchange mechanism. Scandium was extracted quantitatively (> 99.0% from acid solutions. The optimal concentration of di-2-ethylhexylphosphoric acid in the extractant was 0,250 M, quantitative extraction of scandium was observed in the range of its concentrations of 10-3-10-6 M and the volume ratio of organic phases to aqueous phases of 1:5 - 1:20.

  16. Thermodynamic and kinetic study of scandium(III) complexes of DTPA and DOTA: a step toward scandium radiopharmaceuticals.

    Science.gov (United States)

    Pniok, Miroslav; Kubíček, Vojtěch; Havlíčková, Jana; Kotek, Jan; Sabatie-Gogová, Andrea; Plutnar, Jan; Huclier-Markai, Sandrine; Hermann, Petr

    2014-06-23

    Diethylenetriamine-N,N,N',N'',N''-pentaacetic acid (DTPA) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) scandium(III) complexes were investigated in the solution and solid state. Three (45)Sc NMR spectroscopic references suitable for aqueous solutions were suggested: 0.1 M Sc(ClO4)3 in 1 M aq. HClO4 (δSc =0.0 ppm), 0.1 M ScCl3 in 1 M aq. HCl (δSc =1.75 ppm) and 0.01 M [Sc(ox)4](5-) (ox(2-) = oxalato) in 1 M aq. K2C2O4 (δSc =8.31 ppm). In solution, [Sc(dtpa)](2-) complex (δSc = 83 ppm, Δν = 770 Hz) has a rather symmetric ligand field unlike highly unsymmetrical donor atom arrangement in [Sc(dota)](-) anion (δSc = 100 ppm, Δν = 4300 Hz). The solid-state structure of K8[Sc2(ox)7]⋅13 H2O contains two [Sc(ox)3](3-) units bridged by twice "side-on" coordinated oxalate anion with Sc(3+) ion in a dodecahedral O8 arrangement. Structures of [Sc(dtpa)](2-) and [Sc(dota)](-) in [(Hguanidine)]2[Sc(dtpa)]⋅3 H2O and K[Sc(dota)][H6 dota]Cl2⋅4 H2O, respectively, are analogous to those of trivalent lanthanide complexes with the same ligands. The [Sc(dota)](-) unit exhibits twisted square-antiprismatic arrangement without an axial ligand (TSA' isomer) and [Sc(dota)](-) and (H6 dota)(2+) units are bridged by a K(+) cation. A surprisingly high value of the last DOTA dissociation constant (pKa =12.9) was determined by potentiometry and confirmed by using NMR spectroscopy. Stability constants of scandium(III) complexes (log KScL 27.43 and 30.79 for DTPA and DOTA, respectively) were determined from potentiometric and (45)Sc NMR spectroscopic data. Both complexes are fully formed even below pH 2. Complexation of DOTA with the Sc(3+) ion is much faster than with trivalent lanthanides. Proton-assisted decomplexation of the [Sc(dota)](-) complex (τ1/2 =45 h; 1 M aq. HCl, 25 °C) is much slower than that for [Ln(dota)](-) complexes. Therefore, DOTA and its derivatives seem to be very suitable ligands for scandium

  17. Effects of iron on intermetallic compound formation in scandium modified Al–Si–Mg Alloys

    Energy Technology Data Exchange (ETDEWEB)

    Patakham, Ussadawut [National Metal and Materials Technology Center, National Science and Technology Development Agency, 114 Thailand Science Park, Klong Nueng, Klong Luang, Pathumthani 12120 (Thailand); Limmaneevichitr, Chaowalit, E-mail: chaowalit.lim@mail.kmutt.ac.th [Production Engineering Department, Faculty of Engineering, King Mongkut’s University of Technology Thonburi, 126 Pracha-Utid Rd., Bangmod, Tungkhru, Bangkok 10140 (Thailand)

    2014-12-15

    Highlights: • Iron reduces the modification effects of scandium in Al–Si–Mg alloys. • Morphologies of Sc-rich intermetallic phases vary with Fe and Sc contents and the cooling rates. • Sc neutralizes effects of Fe by changing Fe-rich intermetallic phases from platelets to more cubic. - Abstract: In general, iron has a strong tendency to dissolve in molten aluminum. Iron has very low solid solubility in aluminum–silicon casting alloys, so it will form intermetallic compounds that cause detrimental effects on mechanical properties. In this work, the effects of iron on intermetallic compound formations in scandium modified Al–Si–Mg alloys were studied. There were two levels of iron addition (0.2 and 0.4 wt.%) and two levels of scandium addition (0.2 and 0.4 wt.%). We found that the effects of scandium modification decreased with increasing iron addition. The morphologies of the complex intermetallic compounds were characterized by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and electron backscatter diffraction (EBSD) techniques. It was found that scandium changes the morphology of Fe-rich intermetallic compounds from β-phase (plate-like) to α-phase, which reduces the harmful effects of β-phase.

  18. Solvent extraction of scandium from lateritic nickel- cobalt ores using different organic reagents

    Directory of Open Access Journals (Sweden)

    Ferizoğlu Ece

    2016-01-01

    Full Text Available Scandium is the most important and strategic metal that can be recovered as a by-product from lateritic nickel-cobalt ores. In this research, different extractants were investigated in order to extract scandium from a sulfate medium by a using a solvent extraction method. Generally, the organic extractants are classified as acidic, neutral and basic organophosphorus compounds. However, in solvent extraction of scandium, the acidic and neutral organophosphorus compounds are preferred due to their higher extraction efficiencies. Thus, the aim of the present study was to compare the scandium extraction efficiencies of some acidic and neutral organic reagents. For this reason, Ionquest 290 (Bis(2,4,4-trimethylpenthyl phosphonic acid, DEHPA (Di(2-ethylhexyl phosphoric acid, Cyanex 272 ((Bis(2,4,4-trimethylpentyl phosphinic acid which are acidic organophosphorus compounds, and Cyanex 923 (Trialkylphosphine oxide, which is a neutral organophosphorus compound, were used. The extraction capacities of these organics were studied with respect to the extractant concentration at same pH and phase ratio. As a result of the study, DEHPA was found to have higher scandium extraction efficiency with lower iron extraction at pH = 0.55 at a phase ratio of 10:1 = A:O.

  19. Correlation between stoichiometry and properties of scandium oxide films prepared by reactive magnetron sputtering

    Science.gov (United States)

    Belosludtsev, Alexandr; Juškevičius, Kęstutis; Ceizaris, Lukas; Samuilovas, Romanas; Stanionytė, Sandra; Jasulaitienė, Vitalija; Kičas, Simonas

    2018-01-01

    Scandium oxide films were deposited on fused silica substrates by reactive pulsed DC magnetron sputtering. The use of feed-back optical emission monitoring enabled high-rate reactive deposition of films with tunable stoichiometry and properties. The under-stoichiometric, stoichiometric and over-stoichiometric scandium oxide films were prepared. The compressive stress in films was between 235 and 530 MPa. We showed that phase structure, density, surface roughness and optical properties of the scandium oxide are affected by the film stoichiometry and deposition conditions. Transparent scandium oxide films were slightly hydrophobic (94 ± 3°), homogeneous with a crystallite size of 20 ± 5 nm. The lowest extinction coefficient 0.7 × 10-3, the highest refractive index 2.08 (both quantities at the wavelength of 355 nm) and the highest density 4.1 ± 0.1 g cm-3 exhibited film prepared with the stoichiometric composition. Stoichiometric scandium oxide can be used in various optical applications as high refractive index and wide bandgap material. Transitions to under- or over-stoichiometry lead to a decrease of film density, refractive index and increase of the extinction coefficient.

  20. Mossbauer investigation of scandium oxide-hematite nanoparticles

    Science.gov (United States)

    Allwes, Mark; Sorescu, Monica

    Scandium oxide-doped hematite, xSc2O3*(1-x)alpha-Fe2O3 with molar concentration x =0.1, 0.3, and 0.5 was prepared by using ball milling, taking samples at times 0, 2, 4, 8, and 12 hours. The resulting Mossbauer spectra of the nanoparticles systems were parameterized using NORMOS-90. For each concentration, the spectra at 0 hours only consisted of 1 sextet, as the substitution of Sc2O3into Fe2O3 did not appear until after 2 hours of ball milling time (BMT). Concentration x =0.1 at BMT 2hours consisted of 2 sextets while x =0.3 and 0.5 were fit with 1 sextet and 1 quadrupole-split doublet. Concentration x =0.1 at BMT 4 and 8 hours consisted of 3 sextets, and at BMT 12 hours consisted of 4 sextets. For concentrations x =0.3 and 0.5 at BMT 4, 8, and 12 hours the spectra were fit with 3 sextets and 1 quadrupole-split doublet. With increasing initial concentration, the appearance of the quadrupole-split doublet became more pronounced, indicating the substitution of Fe into Sc2O3 occurred. But for x =0.1, the BMT did influence the number of sextets needed, causing an increase in substitution of Sc2O3 into Fe2O3.

  1. Association between toenail scandium levels and risk of acute myocardial infarction in European men: The EURAMIC and Heavy Metals Study

    NARCIS (Netherlands)

    Gómez-Aracena, J.; Martin-Moreno, J.M.; Riemersma, R.A.; Bode, P.; Gutiérrez-Bedmar, M.; Gorgojo, L.; Kark, J.D.; Garcia-Rodríguez, A.; Gomez-Gracia, E.; Kardinaal, A.F.M.; Aro, A.; Veer, P. van 't; Wedel, H.; Kok, F.J.; Fernández-Crehuet, J.

    2002-01-01

    The association between scandium status and risk of acute myocardial infarction (MI) was examined in a multicentre case control study in 10 centres from Europe and Israel. Scandium in toenails was assessed in 684 cases and 724 controls less than 70 years of age. Mean concentrations of toenail

  2. In-source laser spectroscopy developments at TRILIS-towards spectroscopy on actinium and scandium

    Energy Technology Data Exchange (ETDEWEB)

    Raeder, Sebastian, E-mail: raeder@triumf.ca; Dombsky, Marik; Heggen, Henning; Lassen, Jens; Quenzel, Thomas [TRIUMF, Canada' s National Laboratory for Nuclear and Particle Physics (Canada); Sjoedin, Marica [GANIL (France); Teigelhoefer, Andrea [TRIUMF, Canada' s National Laboratory for Nuclear and Particle Physics (Canada); Wendt, Klaus [Johannes Gutenberg-Universitaet Mainz, Institut fuer Physik (Germany)

    2013-04-15

    Resonance Ionization Laser Ion Sources (RILIS) have become a versatile tool for production and study of exotic nuclides at Isotope Separator On-Line (ISOL) facilities such as ISAC at TRIUMF. The recent development and addition of a grating tuned spectroscopy laser to the TRIUMF RILIS solid state laser system allows for wide range spectral scans to investigate atomic structures on short lived isotopes, e.g., those from the element actinium, produced in uranium targets at ISAC. In addition, development of new and improved laser ionization schemes for rare isotope production at ISAC is ongoing. Here spectroscopic studies on bound states, Rydberg states and autoionizing (AI) resonances on scandium using the existing off-line capabilities are reported. These results allowed to identify a suitable ionization scheme for scandium via excitation into an autoionizing state at 58,104 cm{sup - 1} which has subsequently been used for ionization of on-line produced exotic scandium isotopes.

  3. Process and Mechanical Properties: Applicability of a Scandium modified Al-alloy for Laser Additive Manufacturing

    Science.gov (United States)

    Schmidtke, K.; Palm, F.; Hawkins, A.; Emmelmann, C.

    The applicability of an aluminium alloy containing scandium for laser additive manufacturing (LAM) is considered. Modified aluminium alloys with a scandium content beyond the eutectic point offer great potential to become a high prioritized aerospace material. Depending on other alloying elements like magnesium or zirconium, strongly required weight reduction, corrosion resistance and improved strength properties of metallic light weight alloys can be achieved. The development, production and testing of parts built up by a laser powder bed process will be presented with regard to the qualification of the new material concept "ScalmalloyRP®" for laser additive manufacturing.

  4. Synthesis and structural characterization of scandium SALEN complexes.

    Science.gov (United States)

    Meermann, Christian; Sirsch, Peter; Törnroos, Karl W; Anwander, Reiner

    2006-02-28

    A series of heteroleptic scandium SALEN complexes, [(SALEN)Sc(mu-Cl)]2 and (SALEN)Sc[N(SiHMe2)2] is obtained via amine elimination reactions using [Sc(N(i)Pr2)2(mu-Cl)(THF)]2 and Sc[N(SiHMe2)2]3(THF) as metal precursors, respectively. H(2)SALEN ligand precursors comprising H2Salen [(1,2-ethandiyl)bis(nitrilomethylidyne)bis(2,4-di-tert-butyl)phenol], H2Salpren [(2,2-dimethylpropanediyl)bis(nitrilomethylidyne)bis(2,4-di-tert-butyl)phenol], H2Salcyc [(1R,2R)-(-)-1,2-cyclohexanediyl)bis(nitrilomethylidyne)bis(2,4-di-tert-butyl)phenol] and H2Salphen [((1S,2S)-(-)-1,2-diphenylethandiyl)bis(nitrilomethylidyne)bis(2,4-di-tert-butyl)phenol] are selected according to solubility and ligand backbone variation ("=N-(R)-N=" bite angle) criteria. Consideration is given to the feasibility of [Cl --> NR2] and [N(SiHMe2)2--> OSiR3] secondary ligand exchange reactions. X-ray crystal structure analyses of donor-free (Salpren)Sc(N(i)Pr2), (R,R)-(Salcyc)Sc[N(SiHMe2)2], (Salen)Sc(OSi(t)BuPh2) and (Salphen)Sc(OSiH(t)Bu2) reveal (i) a very short Sc-N bond distance of 2.000(3) A, (ii) weak beta(Si-H)(amido)-Sc agostic interactions and (iii) an exclusive intramolecularly tetradentate and intrinsically bent coordination mode of the SALEN ligands with angle(Ph,Ph) dihedral angles and Sc-[N(2)O(2)] distances in the 124.27(9)-127.7(3) degrees and 0.638(1)-0.688(1) A range, respectively.

  5. Scandium SALEN complexes bearing chloro, aryloxo, and hydroxo ligands.

    Science.gov (United States)

    Meermann, Christian; Törnroos, Karl W; Anwander, Reiner

    2009-03-16

    Heteroleptic amide complexes (SALEN)Sc[N(SiHMe(2))(2)] (SALEN = Salen(tBu,tBu), Salcyc(tBu,tBu), or Salpren(tBu,tBu) if not stated differently) were examined as synthesis precursors according to silylamine elimination reactions. Treatment of (SALEN)Sc[N(SiHMe(2))(2)] with H(2)O or phenols (HOAr(R,R); R = tBu, iPr) afforded complexes [(SALEN)Sc(mu-OH)](2) and (SALEN)Sc(OAr(R,R)), while chloro exchange products were formed from the respective reactions with NH(4)Cl or AlMe(2)Cl. Such complexes [(SALEN)Sc(mu-Cl)](2) and (SALEN)ScCl(thf) were also obtained by utilizing alternative synthesis protocols, allowing for controlled donor absence and presence. Heteroleptic amide precursors [Sc(NiPr(2))(2)(mu-Cl)(thf)](2) and [Sc[N(SiHMe(2))(2)](2)(mu-Cl)(thf)](2) readily undergo amine elimination reactions with H(2)SALEN derivatives to form the corresponding chloride complexes. Spectroscopic and X-ray structural data of the heteroleptic scandium complexes revealed an exclusive intramolecular tetradentate coordination mode of the SALEN ligands independent of the SALEN ligand bite angle and the nature of the "second" ligand (chloro, amido, aryloxo, hydroxo). The coordination of the SALEN ligands is rationalized on the basis of (a) the displacement d of the metal center from the [N(2)O(2)] least-squares plane, (b) the dihedral angle alpha between the phenyl rings of the salicylidene moieties, and (c) the angle beta = Ct-Ln-Ct (Ct = centroid of the phenyl rings) in the case of strongly twisted ligands.

  6. Vertical distribution of scandium in the north central Pacific

    Science.gov (United States)

    Amakawa, Hiroshi; Nomura, Miho; Sasaki, Kazunori; Oura, Yasuji; Ebihara, Mitsuru

    2007-06-01

    The concentrations of scandium (Sc) in seawater, which have remained unreported since the early 1970s, were determined together with those of yttrium (Y) and lanthanides (Ln) with samples from the north central Pacific Ocean (St. BO-3). The Sc concentration shows a so-called nutrient-like profile: it increases gradually from the surface (about 2 pmol/kg) to the ocean floor (about 20 pmol/kg). That pattern closely resembles those of Y and Ln (correlation coefficient (r) > 0.92). Some light-to-middle Ln (Pr-Tb) exhibit a closer correlation with Sc than do Y, La, or heavy Ln (Ho-Lu). In contrast, Y/Sc and Ln/Sc ratios (elemental abundance ratios) indicate that Sc is depleted compared to either Y or Ln in seawater more than in loess, which represents chemical compositions of crustal material. These observations offer a conflicting view of chemical reactivity related Y, Ln, and Sc: r values show that the chemical reactivity of Sc resembles those of Y and Ln, but differences of Y/Sc and Ln/Sc ratios in seawater and in loess suggest that the chemical reactivity of Sc differs from those of Y and Ln. More Sc data for seawater are necessary to clarify the chemical reactivity of Sc in the ocean. We also propose that comparative studies of vertical profiles of Sc and such elements as Fe, Ti, Zr, and Hf showing so-called nutrient-like profiles at the same oceanic stations would be helpful and effective for clarifying the behavior of Sc in the ocean.

  7. In situ observation of the reaction of scandium and carbon by neutron diffraction

    Energy Technology Data Exchange (ETDEWEB)

    Juarez-Arellano, Erick A., E-mail: eajuarez@unpa.edu.m [Institut fuer Geowissenschaften, Universitaet Frankfurt, Altenhoeferallee 1, 60438 Frankfurt a.M. (Germany); Universidad del Papaloapan, Circuito Central 200, Parque Industrial, Tuxtepec 68301 (Mexico); Winkler, Bjorn [Institut fuer Geowissenschaften, Universitaet Frankfurt, Altenhoeferallee 1, 60438 Frankfurt a.M. (Germany); Vogel, Sven C. [Los Alamos National Laboratory, Lujan Center. Mail Stop H805, Los Alamos, NM 87545 (United States); Senyshyn, Anatoliy [Forschungsneutronenquelle Heinz Maier-Leibnitz (FRM II), Technische Universitaet Muenchen, Lichtenbergstr. 1, D-85747 Garching (Germany); Materialwissenschaft, TU Darmstadt, Petersensstr. 23, D-64287 Darmstadt (Germany); Kammler, Daniel R. [Sandia National Laboratories, Albuquerque, NM 87185 (United States); Avalos-Borja, Miguel [CNyN, UNAM, A. Postal 2681, Ensenada, B.C. (Mexico)

    2011-01-05

    Research highlights: {yields} Exist two ScC cubic phases with B1-structure type differing in site occupancy of C. {yields} A new orthorhombic scandium carbide phase is formed at 1473(50) K. {yields} The recrystallization of alpha-Sc occurs between 1000 and 1223 K. - Abstract: The formation of scandium carbides by reaction of the elements has been investigated by in situ neutron diffraction up to 1823 K. On heating, the recrystallization of {alpha}-Sc occurs between 1000 and 1223 K. The formation of Sc{sub 2}C and ScC (NaCl-B1 type structure) phases has been detected at 1323 and 1373 K, respectively. The formation of a new orthorhombic scandium carbide phase was observed at 1473(50) K. Once the scandium carbides are formed they are stable upon heating or cooling. No other phases were detected in the present study, in which the system was always carbon saturated. The thermal expansion coefficients of all phases have been determined, they are constant throughout the temperature interval studied.

  8. The effects of aluminum or scandium on the toughness, density and ...

    African Journals Online (AJOL)

    The effects of the substitution of aluminum or scandium on the density, toughness as well as the stability of the phases formed by such an addition on platinum, iridium, rhodium and palladium metals were evaluated with the density functional quantum mechanical calculation methods. All the metals had four atoms per ...

  9. Effects of erbium‑and chromium‑doped yttrium scandium gallium ...

    African Journals Online (AJOL)

    2014-08-21

    Aug 21, 2014 ... surfaces because of its high power, and the ablation was deeper for these samples. High‑magnification SEM ... Key words: Erbium chromium‑doped yttrium scandium gallium garnet, diode laser, restorative dental materials, scanning electron ... garnet (Nd: YAG) and carbon dioxide (CO2) lasers on indirect ...

  10. Chemical and biological evaluation of scandium(III)-polyaminopolycarboxylate complexes as potential PET agents and radiopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    Huclier-Markai, S.; Sabatie, A.; Ribet, S. [Univ. de Nantes (France). Lab. Subatech; Kubicek, V.; Hermann, P. [Charles Univ., Prague (Czech Republic). Dept. of Inorganic Chemistry; Paris, M. [Univ. de Nantes (France). Inst. des Materiaux; Vidaud, C. [CEA/DSV/iBEB/SBTN, Bagnols sur Ceze (France). Lab. d' Etude des Proteines Cibles; Cutler, C.S. [Univ. of Missouri, Columbia, MO (United States). Reserach Reactor Center

    2011-07-01

    Scandium isotopes ({sup 44}Sc, {sup 47}Sc) are more available and their properties are convenient for either PET imaging or radiotherapy. To use them in nuclear medicine, ligands forming complexes with a high stability are necessary. Available experimental data on stability constants for complexes of ligands such as EDTA, DTPA, DOTA, NOTA and TETA with various metal ions have been published. But scandium is the exception since scarce data is available in the literature. Values of stability constants of Sc(III) with the ligands were determined by free-ion selective radiotracer extraction, complemented by {sup 45}Sc NMR and potentiometry data. The thermodynamic stability of the Sc-complexes increases in the order TETA < NOTA < EDTA < DTPA < DOTA. The in vitro stability of the Sc(III) complexes was studied in the presence of hydroxyapatite and rat serum to estimate their in vivo stability. The most stable complex was shown to be Sc-DOTA.

  11. Precipitation behaviour and recrystallisation resistance in aluminum alloys with additions of hafnium, scandium and zirconium

    OpenAIRE

    Hallem, Håkon

    2005-01-01

    The overall objective of this work has been to develop aluminium alloys, which after hot and cold deformation are able to withstand high temperatures without recrystallising. This has been done by investigating aluminium alloys with various additions of hafnium, scandium and zirconium, with a main focus on Hf and to which extent it may partly substitute or replace Zr and/or Sc as a dispersoid forming elements in these alloys. What is the effect of hafnium, alone and in combination with Zr...

  12. Pilot-scale recovery of rare earths and scandium from phosphogypsum and uranium leachates

    Directory of Open Access Journals (Sweden)

    Mashkovtsev Maxim

    2016-01-01

    Full Text Available Ural Federal University (UrFU and VTT have performed joint research on development of industrial technologies for the extraction of REM and Scandium compounds from phosphogypsum and Uranium ISL leachate solutions. Leaching-absorption experiments at UrFU have been supported with multicomponent solution modelling by VTT. The simulations have been performed with VTT’s ChemSheet/Balas program and can be used for speciation calculations in the lixiviant solution. The experimental work combines solvent extraction with advanced ion exchange methodology in a pilot facility capable of treating 5 m3 solution per hour. Currently, the plant produces cerium carbonate, lanthanum oxide, neodymium oxide and concentrate of heavy rare earth metals. A batch of 45 t solids has been processed with the gain of 100 kg’s of REM concentrate. A mini-pilot plant with productivity above 50 liters per hour has been applied to recover scandium oxide and REE concentrates from the uranium ISL solution. As the preliminary product contains radioactivity (mainly strontium, an additional decontamination and cleaning of both concentrates by extraction has rendered a necessity. Finally a purified 99% concentrate of scandium oxide as well as 99% rare earth concentrate are received.

  13. Optimization of scandium oxide growth by high pressure sputtering on silicon

    Energy Technology Data Exchange (ETDEWEB)

    Feijoo, P.C., E-mail: pedronska@fis.ucm.es; Pampillon, M.A.; San Andres, E.; Lucia, M.L.

    2012-12-30

    This work demonstrates the viability of scandium oxide deposition on silicon by means of high pressure sputtering. Deposition pressure and radio frequency power are varied for optimization of the properties of the thin films and the ScO{sub x}/Si interface. The physical characterization was performed by ellipsometry, Fourier transform infrared spectroscopy, x-ray diffraction and transmission electron microscopy. Aluminum gate electrodes were evaporated for metal-insulator-semiconductor (MIS) fabrication. From the electrical characterization of the MIS devices, the density of interfacial defects is found to decrease with deposition pressure, showing a reduced plasma damage of the substrate surface for higher pressures. This is also supported by lower flatband voltage shifts in the capacitance versus voltage hysteresis curves. Sputtering at high pressures (above 100 Pa) reduces the interfacial SiO{sub x} formation, according to the infrared spectra. The growth rates decrease with deposition pressure, so a very accurate control of the layer thicknesses could be provided. - Highlights: Black-Right-Pointing-Pointer Scandium oxide is considered as a high permittivity dielectric. Black-Right-Pointing-Pointer Scandium oxide was deposited on Si by high pressure sputtering. Black-Right-Pointing-Pointer Characterization was performed for deposition condition optimization. Black-Right-Pointing-Pointer High deposition pressures showed higher film and interface quality.

  14. Recovery of Scandium from Leachate of Sulfation-Roasted Bayer Red Mud by Liquid-Liquid Extraction

    Science.gov (United States)

    Liu, Zhaobo; Li, Hongxu; Jing, Qiankun; Zhang, Mingming

    2017-11-01

    The leachate obtained from sulfation-roasted Bayer red mud is suitable for extraction of scandium by liquid-liquid solvent extraction because it contains trace amounts of Fe3+ and Si4+. In this study, a completely new metallurgical process for selective recovery of scandium from Bayer red mud was proposed. The extraction performances of Sc3+, Fe3+, Al3+, Si4+, Ca2+, and Na+ from synthetic leachate of sulfation-roasted red mud were first investigated using organophosphorus extractants (di-2-ethylhexyl phosphoric acid P204 and 2-ethylhexyl phosphoric acid mono-2-ethylhexyl ester P507) and carboxylic acid extractant (Versatic acid 10). It shows that P204 has an excellent extraction ability and that it can be applied to the scandium recovery. P507 and Versatic acid 10 are much poorer in performance for selective extraction of scandium. In the leachate of sulfation-roasted red mud, approximately 97% scandium can be recovered using a P204/sulfonated kerosene (1% v/v) extraction system under the condition of an organic-to-aqueous phase ratio of 10:1 and with an extraction temperature of 15°C.

  15. Scandium-doped zinc cadmium oxide as a new stable n-type oxide thermoelectric material

    DEFF Research Database (Denmark)

    Han, Li; Christensen, Dennis Valbjørn; Bhowmik, Arghya

    2016-01-01

    Scandium-doped zinc cadmium oxide (Sc-doped ZnCdO) is proposed as a new n-type oxide thermoelectric material. The material is sintered in air to maintain the oxygen stoichiometry and avoid instability issues. The successful alloying of CdO with ZnO at a molar ratio of 1 : 9 significantly reduced...... is a good candidate for improving the overall conversion efficiencies in oxide thermoelectric modules. Meanwhile, Sc-doped ZnCdO is robust in air at high temperatures, whereas other n-type materials, such as Al-doped ZnO, will experience rapid degradation of their electrical conductivity and ZT....

  16. Scandium and yttrium phosphasalen complexes as initiators for ring-opening polymerization of cyclic esters.

    Science.gov (United States)

    Bakewell, Clare; White, Andrew J P; Long, Nicholas J; Williams, Charlotte K

    2015-03-02

    The synthesis and characterization of novel scandium and yttrium phosphasalen complexes is reported, where phosphasalen refers to two different bis(iminophosphorane) derivatives of the more ubiquitous salen ligands. The activity of the complexes as initiators for the ring-opening polymerization of cyclic esters is presented. The scandium complexes are inactive for lactide polymerization but slow and controlled initiators for ε-caprolactone polymerization. The lack of activity toward lactide exhibited by these compounds is probed, and a rare example of single-monomer insertion product, unable to undergo further reactions with lactide, is identified. In contrast, the analogous yttrium phosphasalen complex is a very active initiator for the ring-opening polymerization of rac-lactide (kobs = 1.5 × 10(-3) s(-1) at 1:500 [yttrium initiator]:[rac-lactide], 1 M overall concentration of lactide in THF at 298 K). In addition to being a very fast initiator, the yttrium complex also maintains excellent levels of polymerization control and a high degree of isoselectivity, with the probability of isotactic enchainment being Pi = 0.78 at 298 K.

  17. Thermodynamic parameters of scandium trifluoride and triiodide in the condensed state

    Science.gov (United States)

    Aristova, N. M.; Belov, G. V.

    2015-06-01

    The thermodynamic properties of new classes of compounds, particularly scandium trihalides ScF3, ScCl3, ScBr3, and ScI3, are added to the IVTANTHERMO software package. A critical analysis and processing of the entire array of primary data available in the literature is performed. An equation approximating the temperature dependence of heat capacity in the temperature range 298.15- T m (K) is derived for each crystalline scandium trihalide. The resulting equations C {/p po}( T) for the solid state and the data for the liquid phase are used to calculate the thermodynamic functions of entropy, the reduced Gibbs free energies, and the enthalpy increments. Both the experimental data available in literature and the missing estimated thermodynamic data are used in calculations. The error of the recommended values is estimated in all cases. In the first part of this work, we describe the thermodynamic properties of ScF3 and ScI3 used as the reference data for calculating the thermodynamic functions of ScCl3 and ScBr3, for which experimental data are either very scarce or missing altogether. The resulting data are added to the database of the IVTANTHERMO software package.

  18. Recovery of Scandium(III) from Aqueous Solutions by Solvent Extraction with the Functionalized Ionic Liquid Betainium Bis(trifluoromethylsulfonyl)imide

    OpenAIRE

    Onghena, Bieke; Binnemans, Koen

    2015-01-01

    The ionic liquid betainium is(trifluoromethylsulfonyl)imide [Hbet][Tf2N] was used for the extraction of scandium from aqueous solutions. The influence of several extraction parameters on the extraction efficiency was investigated, including the initial metal concentration, phase ratio, and pH. The extraction kinetics was examined, and a comparison was made between conventional liquid−liquid extraction and homogeneous liquid−liquid extraction (HLLE). The stoichiometry of the extracted scandium...

  19. Modification mechanism of eutectic silicon in Al–6Si–0.3Mg alloy with scandium

    Energy Technology Data Exchange (ETDEWEB)

    Patakham, Ussadawut [Manufacturing and Systems Engineering Program, Department of Production Engineering, Faculty of Engineering, King Mongkut’s University of Technology Thonburi, 126 Pracha-Utid Rd., Bangmod, Tungkhru, Bangkok 10140 (Thailand); Kajornchaiyakul, Julathep [National Metal and Material Technology Center, National Science and Technology Development Agency, 114 Thailand Science Park, Klong Nueng, Klong Luang, Pathumthani 12120 (Thailand); Limmaneevichitr, Chaowalit, E-mail: chaowalit.lim@kmutt.ac.th [Manufacturing and Systems Engineering Program, Department of Production Engineering, Faculty of Engineering, King Mongkut’s University of Technology Thonburi, 126 Pracha-Utid Rd., Bangmod, Tungkhru, Bangkok 10140 (Thailand)

    2013-10-25

    Highlights: •Morphologies and growth of Sc and Sr-modified eutectic silicon resemble those of dendrites. •Crystal orientation of eutectic aluminum depends on growth characteristics of eutectic silicon. •We report strong evidence of the occurrence of an impurity-induced twinning mechanism. -- Abstract: The modification mechanism of eutectic silicon in Al–6Si–0.3Mg alloy with scandium was studied. The crystallographic orientation relationships between primary dendrites and the eutectic phase of unmodified and modified Al–6Si–0.3 Mg alloys were determined using electron backscatter diffraction (EBSD). The orientation of aluminum modified with scandium in the eutectic phase was different from that of the neighboring primary dendrites. This result implies that eutectic aluminum grows epitaxially from the surrounding primary aluminum dendrites in the unmodified alloy and that eutectic aluminum grows competitively from the surrounding primary aluminum dendrites in the modified alloy. The pole figure maps of eutectic Si in the [1 0 0], [1 1 0] and [1 1 1] axes of the unmodified and Sc-modified alloys were different, suggesting that the eutectic Al and Si crystals in modified alloy growth are more isotropic and cover a larger set of directions. The lattice fringes of Si of the alloys with and without Sc modification were different in the TEM results. The lattice fringes of Si in modified alloy were found to be multiple twins. However, this was not observed in the unmodified alloy. The growth characteristic of eutectic Si crystal in modified alloy suggests the occurrence of multiple twinning reactions and the formation of a high density of twins. This modification mechanism by Sc is explained by the results of scanning electron microscopy (SEM), electron backscatter diffraction (EBSD) and transmission electron microscopy (TEM) analysis, which provide strong evidence of the occurrence of the impurity-induced twinning (IIT) mechanism.

  20. Grain refinement mechanism in an Al-Si-Mg alloy with scandium

    Energy Technology Data Exchange (ETDEWEB)

    Patakham, Ussadawut [Department of Production Engineering, Faculty of Engineering, King Mongkut' s University of Technology Thonburi, 126 Pracha-Utid Rd., Bangmod, Tungkhru, Bangkok 10140 (Thailand); Kajornchaiyakul, Julathep [National Metal and Material Technology Center, National Science and Technology Development Agency, 114 Thailand Science Park, Klong Nueng, Klong Luang, Pathumthani 12120 (Thailand); Limmaneevichitr, Chaowalit, E-mail: chaowalit.lim@kmutt.ac.th [Department of Production Engineering, Faculty of Engineering, King Mongkut' s University of Technology Thonburi, 126 Pracha-Utid Rd., Bangmod, Tungkhru, Bangkok 10140 (Thailand)

    2012-11-25

    Highlights: Black-Right-Pointing-Pointer Scandium can be used to refine aluminum grains in an Al-Si-Mg aluminum alloy. Black-Right-Pointing-Pointer The effectiveness of Sc is lower than that of conventional Al-Ti grain refiners. Black-Right-Pointing-Pointer Al{sub 3}Sc particles can act as heterogeneous nuclei of aluminum phases. Black-Right-Pointing-Pointer Higher alloying elements cause more intermetallic compound phases. Black-Right-Pointing-Pointer Those phases cannot effectively act as heterogeneous nuclei compared with Al{sub 3}Sc particles. - Abstract: Grain refinement of the primary aluminum ({alpha}-Al) phase in a hypoeutectic Al-Si alloy using scandium (Sc) was studied to identify the grain refinement mechanism. Optical microscopy (OM), Scanning electron microscopy (SEM) with energy dispersive spectroscopy (EDS) and electron backscatter diffraction (EBSD) techniques were extensively used in this study. We found that Sc refined grains of primary aluminum. However, the grain refinement efficiency of Sc was considerably lower than that of titanium (Ti) in the Al-Si-Mg foundry alloy. It was evident that the precipitated Sc-containing phases acted as heterogeneous nucleation sites for the primary aluminum phase. The Sc-containing heterogeneous sites are irregular in shape with sizes between 3 and 5 {mu}m. At least three groups of nuclei based on their chemical composition were found, i.e., (i) Al and Sc, (ii) Al, Si, Mg, and Sc, and (iii) Al, Si, Mg, Sc, and Fe. Crystal orientation mapping showed primary aluminum dendrites with one orientation in each grain near Al{sub 3}Sc particles. The grain refinement mechanism of Sc for aluminum relies on heterogeneous nucleation of Al{sub 3}Sc particles, with less responsibly for grain growth restriction. Many intermetallic phases with Al, Si, Fe, Mg and Sc as their major components were found, and these phases could not effectively act as heterogeneous nuclei.

  1. Neutron and Charged-Particle Induced Cross Sections for Radiochemistry for Isotopes of Scandium, Titanium, Vanadium, Chromium, Manganese, and Iron

    Energy Technology Data Exchange (ETDEWEB)

    Kelley, K; Hoffman, R D; Dietrich, F S; Bauer, R; Mustafa, M

    2004-11-30

    We have developed a set of modeled nuclear reaction cross sections for use in radiochemical diagnostics. Local systematics for the input parameters required by the Hauser-Feshbach statistical model were developed and used to calculate neutron and proton induced nuclear reaction cross sections in the mass region of scandium, titanium, vanadium, chromium, manganese, and iron (21 {le} Z {le} 26, 20 {le} N {le} 32).

  2. A composite cathode based on scandium doped titanate with enhanced electrocatalytic activity towards direct carbon dioxide electrolysis.

    Science.gov (United States)

    Yang, Liming; Xie, Kui; Wu, Lan; Qin, Qingqing; Zhang, Jun; Zhang, Yong; Xie, Ting; Wu, Yucheng

    2014-10-21

    A composite cathode based on redox-stable La0.2Sr0.8TiO(3+δ) (LSTO) can perform direct carbon dioxide electrolysis; however, the insufficient electro-catalytic activity limits the electrode performances and current efficiencies. In this work, catalytically active scandium is doped into LSTO to enhance the electro-catalytic activity for CO2 electrolysis. The structures, electronic conductivities and ionic conductivities of La0.2Sr0.8Ti(1-x)Sc(x)O (LSTS(x)O) (x = 0, 0.05, 0.1, 0.15 and 0.2) are systematically studied and further correlated with electrode performances. The ionic conductivities of single-phase LSTS(x)O (x = 0, 0.05, 0.1 and 0.15) remarkably improve versus the scandium doping contents though the electrical conductivities gradually change in an adverse trend. Electrochemical measurements demonstrate promising electrode polarisation of LSTS(x)O electrodes and increasing scandium doping contents accordingly improve electrode performances. The Faradic efficiencies of carbon dioxide electrolysis are enhanced by 20% with LSTS0.15O in contrast to bare LSTO electrodes in a solid oxide electrolyser at 800 °C.

  3. Adsorption of hydrogen in Scandium/Titanium decorated nitrogen doped carbon nanotube

    Energy Technology Data Exchange (ETDEWEB)

    Mananghaya, Michael, E-mail: mikemananghaya@gmail.com [De La Salle University, 2401 Taft Ave, 0922, Manila (Philippines); DLSU STC Laguna Boulevard, LTI Spine Road Barangays Biñan and Malamig, Biñan City, Laguna (Philippines); DOST-ASTHRDP, PCIEERD, Gen. Santos Ave., Bicutan, Taguig City 1631 (Philippines); Belo, Lawrence Phoa; Beltran, Arnel [De La Salle University, 2401 Taft Ave, 0922, Manila (Philippines); DLSU STC Laguna Boulevard, LTI Spine Road Barangays Biñan and Malamig, Biñan City, Laguna (Philippines)

    2016-09-01

    Nitrogen doped Carbon Nanotube with divacancy (4ND-CN{sub x}NT) that is decorated with Scandium and Titanium as potential hydrogen storage medium using the pseudo potential density functional method was investigated. Highly localized states near the Fermi level, which are derived from the nitrogen defects, contribute to strong Sc and Ti bindings, which prevent metal aggregation and improve the material stability. A detailed Comparison of the Hydrogen adsorption capability with promising system-weight efficiency of Sc over Ti was elucidated when functionalized with 4ND-CN{sub x}NT. Finally, the (Sc/4ND){sub 10}-CN{sub x}CNT composite material has a thermodynamically favorable adsorption and consecutive adsorption energy for ideal reversible adsorption and desorption of hydrogen at room temperature such that it can hold at least 5.8 wt% hydrogen molecules at the LDA and GGA level. - Highlights: • Carbon Nanotube with divacancy (4ND-CN{sub x}NT) decorated with Sc and Ti. • Nitrogen defects, contribute to strong Sc and Ti bindings. • H{sub 2} and (Sc/4ND){sub 10}-CN{sub x}CNT has a favorable adsorption. • 5.8 wt% adsorption at the LDA and GGA level.

  4. Urinary monitoring of exposure to yttrium, scandium, and europium in male Wistar rats.

    Science.gov (United States)

    Kitamura, Yasuhiro; Usuda, Kan; Shimizu, Hiroyasu; Fujimoto, Keiichi; Kono, Rei; Fujita, Aiko; Kono, Koichi

    2012-12-01

    On the assumption that rare earth elements (REEs) are nontoxic, they are being utilized as replacements of toxic heavy metals in novel technological applications. However, REEs are not entirely innocuous, and their impact on health is still uncertain. In the past decade, our laboratory has studied the urinary excretion of REEs in male Wistar rats given chlorides of europium, scandium, and yttrium solutions by one-shot intraperitoneal injection or oral dose. The present paper describes three experiments for the suitability and appropriateness of a method to use urine for biological monitoring of exposure to these REEs. The concentrations of REEs were determined in cumulative urine samples taken at 0-24 h by inductively coupled plasma atomic emission spectroscopy, showing that the urinary excretion of REEs is <2 %. Rare earth elements form colloidal conjugates in the bloodstream, which make high REEs accumulation in the reticuloendothelial system and glomeruli and low urinary excretion. The high sensitivity of inductively coupled plasma-argon emission spectrometry analytical methods, with detection limits of <2 μg/L, makes urine a comprehensive assessment tool that reflects REE exposure. The analytical method and animal experimental model described in this study will be of great importance and encourage further discussion for future studies.

  5. South African Crime Quarterly 59

    African Journals Online (AJOL)

    SA Crime QuArterly No. 59 • mArCh 2017. De Vos NO v. Minister of Justice and Constitutional. Development. The constitutionality of detaining persons unfit to stand trial. * Franaaz Khan (LLB LLM) is a lecturer in Law, at the University of. KwaZulu-Natal, Durban. Section 35 of the Constitution protects an accused's right to a ...

  6. Selective recovery of vanadium and scandium by ion exchange with D201 and solvent extraction using P507 from hydrochloric acid leaching solution of red mud.

    Science.gov (United States)

    Zhu, Xiaobo; Li, Wang; Tang, Sen; Zeng, Majian; Bai, Pengyuan; Chen, Lunjian

    2017-05-01

    D201 resin and P507 extractant diluted with sulfonated kerosene were used to respectively separate vanadium and scandium, and impurity ions from hydrochloric acid leaching solution of red mud. More than 99% of vanadium was selectively adsorbed from the hydrochloric acid leaching solution under the conditions of pH value of 1.8, volume ratio of leaching solution to resin of 10, and flow rate of 3.33 mL/min. Maximum extraction and separation of scandium was observed from the acid leaching solution at an aqueous pH value of 0.2. More than 99% of scandium can be selectively extracted using 15% P507, 5% TBP at the aqueous solution/organic phase (A/O) ratio of 10:1 for 6 min. The loaded organic phase was washed with 0.3 mol/L sulfuric acid, wherein most impurities were removed. After the process of desorption or stripping, precipitation, and roasting, high-purity V2O5 and Sc2O3 were obtained. Finally, a conceptual flow sheet was established to separate and recover vanadium and scandium from red mud hydrochloric acid leaching solution. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Magnetic Moment of $^{59}$Cu

    CERN Multimedia

    2002-01-01

    Experiment IS358 uses the intense and pure beams of copper isotopes provided by the ISOLDE RILIS (resonance ionization laser ion source). The isotopes are implanted and oriented in the low temperature nuclear orientation set-up NICOLE. Magnetic moments are measured by $\\beta$-NMR. Copper (Z=29), with a single proton above the proton-magic nickel isotopes provides an ideal testground for precise shell model calculations of magnetic moments and their experimental verification. In the course of our experiments we already determined the magnetic moments of $^{67}$Ni, $^{67}$Cu, $^{68g}$Cu, $^{69}$Cu and $^{71}$Cu which provide important information on the magicity of the N=40 subshell closure. In 2001 we plan to conclude our systematic investigations by measuring the magnetic moment of the neutron-deficient isotope $^{59}$Cu. This will pave the way for a subsequent study of the magnetic moment of $^{57}$Cu with a complementary method.

  8. Random-field Potts model for the polar domains of lead magnesium niobate and lead scandium tantalate

    Energy Technology Data Exchange (ETDEWEB)

    Qian, H.; Bursill, L.A

    1997-06-01

    A random filed Potts model is used to establish the spatial relationship between the nanoscale distribution of charges chemical defects and nanoscale polar domains for the perovskite-based relaxor materials lead magnesium niobate (PMN) and lead scandium tantalate (PST). The random fields are not set stochastically but are determined initially by the distribution of B-site cations (Mg, Nb) or (Sc, Ta) generated by Monte Carlo NNNI-model simulations for the chemical defects. An appropriate random field Potts model is derived and algorithms developed for a 2D lattice. It is shown that the local fields are strongly correlated with the chemical domain walls and that polar domains as a function of decreasing temperature is simulated for the two cases of PMN and PST. The dynamics of the polar clusters is also discussed. 33 refs., 9 figs.

  9. 49 CFR 192.59 - Plastic pipe.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Plastic pipe. 192.59 Section 192.59 Transportation... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Materials § 192.59 Plastic pipe. (a) New plastic pipe... specification; and (2) It is resistant to chemicals with which contact may be anticipated. (b) Used plastic pipe...

  10. 42 CFR 59.11 - Confidentiality.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Confidentiality. 59.11 Section 59.11 Public Health... Project Grants for Family Planning Services § 59.11 Confidentiality. All information as to personal facts... confidentiality. Otherwise, information may be disclosed only in summary, statistical, or other form which does...

  11. 33 CFR 401.59 - Pollution.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Pollution. 401.59 Section 401.59 Navigation and Navigable Waters SAINT LAWRENCE SEAWAY DEVELOPMENT CORPORATION, DEPARTMENT OF TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Seaway Navigation § 401.59 Pollution. (a) No vessel shall: (1...

  12. 14 CFR 65.59 - Skill requirements.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Skill requirements. 65.59 Section 65.59 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: AIRMEN OTHER THAN FLIGHT CREWMEMBERS Aircraft Dispatchers § 65.59 Skill requirements. An...

  13. 49 CFR 230.59 - Fusible plugs.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Fusible plugs. 230.59 Section 230.59 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Fusible Plugs § 230.59 Fusible plugs. If boilers are equipped with fusible plugs, the plugs shall be...

  14. 12 CFR 622.59 - Assessment order.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Assessment order. 622.59 Section 622.59 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM RULES OF PRACTICE AND PROCEDURE Rules and Procedures for Assessment and Collection of Civil Money Penalties § 622.59 Assessment order. (a) Consent. In the event of consent of the parties...

  15. 40 CFR 59.630 - EPA testing.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 5 2010-07-01 2010-07-01 false EPA testing. 59.630 Section 59.630... Emissions From New and In-Use Portable Fuel Containers Certifying Emission Families § 59.630 EPA testing. We... production sample testing. Upon our request, a manufacturer must supply a prototype container or a reasonable...

  16. 50 CFR 32.59 - Rhode Island.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Rhode Island. 32.59 Section 32.59 Wildlife... § 32.59 Rhode Island. The following refuge units have been opened for hunting and/or fishing and are listed in alphabetical order with applicable refuge-specific regulations. Block Island National Wildlife...

  17. 42 CFR 59.212 - Grantee accountability.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Grantee accountability. 59.212 Section 59.212 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR FAMILY PLANNING SERVICES Grants for Family Planning Service Training § 59.212 Grantee accountability. (a...

  18. 49 CFR 38.59 - Floor surfaces.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Floor surfaces. 38.59 Section 38.59 Transportation Office of the Secretary of Transportation AMERICANS WITH DISABILITIES ACT (ADA) ACCESSIBILITY SPECIFICATIONS FOR TRANSPORTATION VEHICLES Rapid Rail Vehicles and Systems § 38.59 Floor surfaces. Floor surfaces...

  19. 28 CFR 59.1 - Introduction.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Introduction. 59.1 Section 59.1 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) GUIDELINES ON METHODS OF OBTAINING DOCUMENTARY MATERIALS HELD BY THIRD PARTIES § 59.1 Introduction. (a) A search for documentary materials necessarily involves...

  20. 45 CFR 86.59 - Advertising.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Advertising. 86.59 Section 86.59 Public Welfare... in Employment in Education Programs or Activities Prohibited § 86.59 Advertising. A recipient shall not in any advertising related to employment indicate preference, limitation, specification, or...

  1. 7 CFR 15a.59 - Advertising.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Advertising. 15a.59 Section 15a.59 Agriculture Office... FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs and Activities Prohibited § 15a.59 Advertising. A recipient shall not in any advertising related to employment...

  2. 49 CFR 801.59 - Geological records.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Geological records. 801.59 Section 801.59... PUBLIC AVAILABILITY OF INFORMATION Exemption From Public Disclosure § 801.59 Geological records. Pursuant to 5 U.S.C. 552(b)(9), records concerning geological wells are exempt from public disclosure. ...

  3. Development of methods for the selective separation of scandium, zirconium and tin for radiopharmaceutical applications; Entwicklung von Methoden zur selektiven Trennung von Scandium, Zirkonium und Zinn fuer radiopharmazeutische Anwendungen

    Energy Technology Data Exchange (ETDEWEB)

    Dirks-Fandrei, Carina

    2014-07-01

    The subject of the present work is the development of fast and highly selective methods for the separation and purification of scandium, zirconium and tin radionuclides from potential target materials for use in nuclear medicine. A number of selected resins (TrisKem International) were first characterized with respect to their extraction behaviour towards a large number of cations. Characterization studies were performed in batch experiments by determination of weight distribution ratios D{sub w} and further the influence of interferences on the uptake of these elements was evaluated. Weight distribution ratios were determined in different acids and acid concentrations with main focus on scandium, tin or zirconium. The interference of macro amounts of Calcium and Ti on the Sc extraction was evaluated as well as the interference of macro amounts of Y on the Zr extraction. Best suited uptake conditions were found for Scandium on DGA were determined to be 2.5 M HNO{sub 3} for Ti-Targets and 0.1 M HNO{sub 3} for Calcium-Targets. Otherwise it is also possible to extract Sc with TRU Resin. High uptakes were obtained at 2.5 M HNO{sub 3} for simulated Ti- and Calcium-targets. Separation methods were developed using elution studies; employed conditions were chosen according to parameters evaluated in the batch-experiment. The developed methods allowed separating Sc very rapidly in high purity very rapidly from Ti- or Calcium-targets. For Zr a separation method based on UTEVA Resin has been developed. Following results of batch experiments simulated Y-target solution were loaded onto a UTEVA resin column from 6 M HNO{sub 3}; the elution of Zr could be performed in 0.01 M oxalic acid. Decontamination factors in the order of 10{sup 4}-10{sup 5} could be obtained applying the developed method; the method thus allowed separating Zr in a high purity. Initial testing of a method for the separation of Sn from Cd targets based on the use of TBP Resin showed that the TBP resin seems

  4. 27 CFR 27.59 - Wines.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Wines. 27.59 Section 27.59 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE... more than 24 percent of alcohol by volume are required to be packaged, marked, branded, and labeled in...

  5. 38 CFR 59.120 - Hearings.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Hearings. 59.120 Section 59.120 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) GRANTS TO... State by letter that a grant is tentatively denied, explain the reasons for the tentative denial, and...

  6. 38 CFR 59.170 - Forms.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Forms. 59.170 Section 59.170 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) GRANTS TO... Forms, or at the Veterans Health Administration, Room 789, 810 Vermont Ave., NW., Washington, DC 20420...

  7. 38 CFR 59.30 - Documentation.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Documentation. 59.30 Section 59.30 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) GRANTS TO... grant and grant funds under this part, the State must submit to VA documentation that the site of the...

  8. 38 CFR 59.123 - Conference.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Conference. 59.123 Section 59.123 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) GRANTS... grant with VA officials. (Authority: 38 U.S.C. 101, 501, 1710, 1742, 8105, 8131-8137) ...

  9. 34 CFR 106.59 - Advertising.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Advertising. 106.59 Section 106.59 Education Regulations of the Offices of the Department of Education OFFICE FOR CIVIL RIGHTS, DEPARTMENT OF EDUCATION... Advertising. A recipient shall not in any advertising related to employment indicate preference, limitation...

  10. C59N Peapods Sensing the Temperature

    Directory of Open Access Journals (Sweden)

    Toshiro Kaneko

    2013-01-01

    Full Text Available We report the novel photoresponse of nanodevices made from azafullerene (C59N-encapsulated single-walled carbon nanotubes (C59N@SWNTs, so called peapods. The photoconducting properties of a C59N@SWNT are measured over a temperature range of 10 to 300 K under a field-effect transistor configuration. It is found that the photosensitivity of C59N@SWNTs depends very sensitively on the temperature, making them an attractive candidate as a component of nanothermometers covering a wide temperature range. Our results indicate that it is possible to read the temperature by monitoring the optoelectronics signal of C59N@SWNTs. In particular, sensing low temperatures would become more convenient and easy by giving a simple light pulse.

  11. The impact of an erbium, chromium:yttrium-scandium-gallium-garnet laser with radial-firing tips on endodontic treatment.

    Science.gov (United States)

    Schoop, U; Barylyak, A; Goharkhay, K; Beer, F; Wernisch, J; Georgopoulos, A; Sperr, W; Moritz, A

    2009-01-01

    Radial-firing tips should allow a more homogeneous laser irradiation of root canal walls. The aim of the study was to assess the effects of erbium, chromium:yttrium-scandium-gallium-garnet (Er,Cr:YSGG) laser irradiation in conjunction with those newly designed tips. The investigation comprised bacteriology, morphological evaluations and temperature measurements. Root canals were inoculated with two test strains and laser irradiated with power settings of 0.6 W and 0.9 W and a repetition rate of 20 Hz. Subsequently, the samples were subjected to microbiological evaluation. The morphological changes of the canal walls were assessed by scanning electron microscopy. To reveal possible thermal side effects, we carried out temperature measurements. The bacteriological evaluation revealed a decisive disinfectant effect. Scanning electron microscopy showed the homogeneous removal of smear layer from the root canal walls. The temperature rise at the root surface during the irradiation was moderate, yielding 1.3 degrees C for the 0.6 W setting and 1.6 degrees C for the 0.9 W setting. The investigations indicated that the Er,Cr:YSGG laser, in conjunction with radial-firing tips, is a suitable tool for the elimination of bacteria in root canals and for the removal of smear layer.

  12. Effect of scandium addition on the microstructure, mechanical and wear properties of the spray formed hypereutectic aluminum–silicon alloys

    Energy Technology Data Exchange (ETDEWEB)

    Raghukiran, Nadimpalli; Kumar, Ravi, E-mail: nvrk@iitm.ac.in

    2015-08-12

    Hypereutectic Al–x%Si–0.8Sc alloys (x=13, 16, 19 and 22 wt%) were produced by spray forming. The microstructures of all the alloys exhibited very fine silicon phase with average size of about 5–10 µm irrespective of the silicon content of the alloy. Transmission electron microscopy revealed the presence of a nano-scale scandium rich phase, identified as AlSi{sub 2}Sc{sub 2} (V-phase) uniformly distributed in the alloy. The presence of V-phase resulted in higher matrix hardness (1.34 GPa) in contrast to 1.04 GPa observed in the case of binary Al–Si alloys by nanoindentation. Isothermal heat treatment at 375 °C revealed insignificant coarsening of silicon phase in both binary and ternary alloys. The Al–x%Si–0.8Sc alloys exhibited higher flow stress and tensile strength in contrast to their binary alloy counterparts which was attributed to the bi-modal size distribution of the strengthening phases in the form of nano-scale V-phase and sub-micron to 10 µm size silicon particles. The pin-on-disk wear tests exhibited appreciable improvement in the wear performance of the relatively low-silicon content ternary alloys over their binary counterparts while the high-silicon content binary and ternary alloys exhibited no much difference in the wear performance.

  13. Scandium and Titanium Containing Single-Walled Carbon Nanotubes for Hydrogen Storage: a Thermodynamic and First Principle Calculation.

    Science.gov (United States)

    Mananghaya, Michael; Yu, Dennis; Santos, Gil Nonato; Rodulfo, Emmanuel

    2016-06-15

    The generalized gradient approximation (GGA) to density functional theory (DFT) calculations indicate that the highly localized states derived from the defects of nitrogen doped carbon nanotube with divacancy (4ND-CNxNT) contribute to strong Sc and Ti bindings, which prevent metal aggregation. Comparison of the H2 adsorption capability of Sc over Ti-decorated 4ND-CNxNT shows that Ti cannot be used for reversible H2 storage due to its inherent high adsorption energy. The Sc/4ND-CNxNT possesses favorable adsorption and consecutive adsorption energy at the local-density approximation (LDA) and GGA level. Molecular dynamics (MD) study confirmed that the interaction between molecular hydrogen and 4ND-CNxNT decorated with scandium is indeed favorable. Simulations indicate that the total amount of adsorption is directly related to the operating temperature and pressure. The number of absorbed hydrogen molecules almost logarithmically increases as the pressure increases at a given temperature. The total excess adsorption of hydrogen on the (Sc/4ND)10-CNxNT arrays at 300 K is within the range set by the department of energy (DOE) with a value of at least 5.85 wt%.

  14. 59 MDW/Science and Technology Poster

    Science.gov (United States)

    2017-04-28

    SGYU SUBJECT: Professional Presentation Approval • ’ ...... -""""’ ~ 18 APR 20 17 1. Your paper, entitled 59 MDW/ Science & Technology Poster...presented at/published 59m Medical Wing Chief Scientists Office - Science & Technology to in accordance with MDWI 41-108, has been approved and assigned...Ambulatory Surgical Center (WHASC) internship and residency programs. 3. Please know that if you are a Graduate Health Sciences Education student and

  15. Structures and H2 adsorption properties of porous scandium metal-organic frameworks.

    Science.gov (United States)

    Ibarra, Ilich A; Lin, Xiang; Yang, Sihai; Blake, Alexander J; Walker, Gavin S; Barnett, Sarah A; Allan, David R; Champness, Neil R; Hubberstey, Peter; Schröder, Martin

    2010-12-10

    Two new three-dimensional Sc(III) metal-organic frameworks {[Sc(3)O(L(1))(3)(H(2)O)(3)]·Cl(0.5)(OH)(0.5)(DMF)(4)(H(2)O)(3)}(∞) (1) (H(2)L(1)=1,4-benzene-dicarboxylic acid) and {[Sc(3)O(L(2))(2)(H(2)O)(3)](OH)(H(2)O)(5)(DMF)}(∞) (2) (H(3)L(2)=1,3,5-tris(4-carboxyphenyl)benzene) have been synthesised and characterised. The structures of both 1 and 2 incorporate the trinuclear trigonal planar [Sc(3)(O)(O(2)CR)(6)] building block featuring three Sc(III) centres joined by a central μ(3)-O(2-) donor. Each Sc(III) centre is further bound by four oxygen donors from four different bridging carboxylate anions, and a molecule of water located trans to the μ(3)-O(2-) donor completes the six coordination at the metal centre. Frameworks 1 and 2 show high thermal stability with retention of crystallinity up to 350 °C. The desolvated materials 1a and 2a, in which the solvent has been removed from the pores but with water or hydroxide remaining coordinated to Sc(III), show BET surface areas based upon N(2) uptake of 634 and 1233 m(2) g(-1), respectively, and pore volumes calculated from the maximum N(2) adsorption of 0.25 cm(3) g(-1) and 0.62 cm(3) g(-1), respectively. At 20 bar and 78 K, the H(2) isotherms for desolvated 1a and 2a confirm 2.48 and 1.99 wt% total H(2) uptake, respectively. The isosteric heats of adsorption were estimated to be 5.25 and 2.59 kJ mol(-1) at zero surface coverage for 1a and 2a, respectively. Treatment of 2 with acetone followed by thermal desolvation in vacuo generated free metal coordination sites in a new material 2b. Framework 2b shows an enhanced BET surface area of 1511 m(2) g(-1) and a pore volume of 0.76 cm(3) g(-1), with improved H(2) uptake capacity and a higher heat of H(2) adsorption. At 20 bar, H(2) capacity increases from 1.99 wt% in 2a to 2.64 wt% for 2b, and the H(2) adsorption enthalpy rises markedly from 2.59 to 6.90 kJ mol(-1).

  16. STAR FORMATION NEAR BERKELEY 59: EMBEDDED PROTOSTARS

    Energy Technology Data Exchange (ETDEWEB)

    Rosvick, J. M. [Department of Physical Sciences, Thompson Rivers University, 900 McGill Road, Kamloops, BC V2C 0C8 (Canada); Majaess, D. [Department of Astronomy and Physics, Saint Mary' s University, Halifax, NS B3H 3C3 (Canada)

    2013-12-01

    A group of suspected protostars in a dark cloud northwest of the young (∼2 Myr) cluster Berkeley 59 and two sources in a pillar south of the cluster have been studied in order to determine their evolutionary stages and ascertain whether their formation was triggered by Berkeley 59. Narrowband near-infrared observations from the Observatoire du Mont Mégantic, {sup 12}CO (J = 3-2) and SCUBA-2 (450 and 850 μm) observations from the JCMT, 2MASS, and WISE images, and data extracted from the IPHAS survey catalog were used. Of 12 sources studied, two are Class I objects, while three others are flat/Class II, one of which is a T Tauri candidate. A weak CO outflow and two potential starless cores are present in the cloud, while the pillar possesses substructure at different velocities, with no outflows present. The CO spectra of both regions show peaks in the range v {sub LSR} = –15 to –17 km s{sup –1}, which agrees with the velocity adopted for Berkeley 59 (–15.7 km s{sup –1}), while spectral energy distribution models yield an average interstellar extinction A{sub V} and distance of 15 ± 2 mag and 830 ± 120 pc, respectively, for the cloud, and 6.9 mag and 912 pc for the pillar, indicating that the regions are in the same vicinity as Berkeley 59. The formation of the pillar source appears to have been triggered by Berkeley 59. It is unclear whether Berkeley 59 triggered the association's formation.

  17. 40 CFR 59.101 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... manufacturer's or importer's specification of the quantities of coating components for mixing a coating. Mobile..., calculated according to the procedures in § 59.104(a) of this subpart. Water hold-out coating means a coating... area before welding is performed, and that provides corrosion resistance to the surface after welding...

  18. 38 CFR 59.50 - Priority list.

    Science.gov (United States)

    2010-07-01

    ... care construction; nursing home construction (e.g., patient privacy); code compliance under the... prioritized the same as in paragraph (a)(1)(vi) of this section. (b)(1) If a State accepts a partial grant for... year, more than one State previously accepted a partial grant under § 59.80(a)(2), these partial-grant...

  19. 42 CFR 59.203 - Eligibility.

    Science.gov (United States)

    2010-10-01

    ... planning or other health services delivery personnel in the skills, knowledge, and attitudes necessary for... PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR FAMILY PLANNING SERVICES Grants for Family Planning Service Training § 59.203 Eligibility. (a) Eligible applicants. Any public or...

  20. Reference: 59 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 59 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u14563930i Kaczorowski Karen...of the circadian clock. 11 2654-65 14563930 2003 Nov The Plant cell Kaczorowski Karen A|Quail Peter H

  1. 42 CFR 59a.5 - Awards.

    Science.gov (United States)

    2010-10-01

    ... HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL LIBRARY OF MEDICINE GRANTS Grants for Establishing, Expanding, and Improving Basic Resources § 59a.5 Awards. (a) General. Within the... establishments, expansion, or improvement will, in the Secretary's judgment, best promote the purposes of section...

  2. 33 CFR 151.59 - Placards.

    Science.gov (United States)

    2010-07-01

    ... Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION VESSELS... Pertains to Pollution from Ships Garbage Pollution and Sewage § 151.59 Placards. (a) This section applies... following: (1) The discharge of plastic or garbage mixed with plastic into any waters is prohibited. (2) The...

  3. Effects of scandium addition on iron-bearing phases and tensile properties of Al–7Si–0.6Mg alloys

    Energy Technology Data Exchange (ETDEWEB)

    Tzeng, Yu-Chih [Department of Mechanical Engineering, National Central University, Jhongli, Taiwan (China); Wu, Chih-Ting [Department of Vehicle Engineering, Army Academy R.O.C., Jhongli, Taiwan (China); Bor, Hui-Yun; Horng, Jain-Long; Tsai, Mu-Lin [Department of Mechanical Engineering, National Central University, Jhongli, Taiwan (China); Institute of Materials Science and Engineering, National Central University, Jhongli, Taiwan (China); Lee, Sheng-Long, E-mail: shenglon@cc.ncu.edu.tw [Department of Mechanical Engineering, National Central University, Jhongli, Taiwan (China); Institute of Materials Science and Engineering, National Central University, Jhongli, Taiwan (China)

    2014-01-21

    Iron is the most deleterious impurity in aluminum alloys and can easily combine with aluminum to form an acicular β-Al{sub 5}FeSi phase that reduces ductility during the solidification of the molten metal. Adding scandium (Sc) to Al–7Si–0.6Mg alloys can transform the acicular β-Al{sub 5}FeSi phase into a comparatively harmless nodular Sc–Fe phase (Al{sub 12}Si{sub 6}Fe{sub 2}(Mg,Sc){sub 5}). This Sc–Fe phase has a lower hardness and elastic modulus than the β-Al{sub 5}FeSi phase; it is thus less likely to initiate cracks in the Al matrix. Moreover, the nodular Sc–Fe phase can improve the fluidity of Al during solidification, reducing interdendritic shrinkage. Tensile testing measurements showed that the elongation of Al–7Si–0.6Mg alloys with 0.04 and 0.12 wt% Sc can be respectively increased by 115% and 110% compared to Al–7Si–0.6Mg without Sc. The corresponding quality indices are increased by 17% and 19%, respectively, suggesting that the tensile properties of Al–7Si–0.6Mg alloys can be enhanced by adding scandium.

  4. Separation of (44)Ti from proton irradiated scandium by using solid-phase extraction chromatography and design of (44)Ti/(44)Sc generator system.

    Science.gov (United States)

    Radchenko, V; Meyer, C A L; Engle, J W; Naranjo, C M; Unc, G A; Mastren, T; Brugh, M; Birnbaum, E R; John, K D; Nortier, F M; Fassbender, M E

    2016-12-16

    Scandium-44g (half-life 3.97h [1]) shows promise for positron emission tomography (PET) imaging of longer biological processes than that of the current gold standard, (18)F, due to its favorable decay parameters. One source of (44g)Sc is the long-lived parent nuclide (44)Ti (half-life 60.0 a). A (44)Ti/(44g)Sc generator would have the ability to provide radionuclidically pure (44g)Sc on a daily basis. The production of (44)Ti via the (45)Sc(p,2n) reaction requires high proton beam currents and long irradiation times. Recovery and purification of no-carrier added (nca) (44)Ti from scandium metal targets involves complex separation chemistry. In this study, separation systems based on solid phase extraction chromatography were investigated, including branched diglycolamide (BDGA) resin and hydroxamate based ZR resin. Results indicate that ZR resin in HCl media represents an effective (44)Ti/(44g)Sc separation system. Copyright © 2016 Elsevier B.V. All rights reserved.

  5. Gd-Sc-based mixed-metal nitride cluster fullerenes: mutual influence of the cage and cluster size and the role of scandium in the electronic structure.

    Science.gov (United States)

    Svitova, Anna L; Popov, Alexey A; Dunsch, Lothar

    2013-03-18

    The influence of the cage as well as of the cluster size has been studied in Gd-Sc nitride cluster fullerenes, which have been synthesized and isolated for these studies. A series of carbon cages ranging from C78 to C88 have been synthesized, isolated, and characterized in detail using absorption and vibrational spectroscopy as well as electrochemistry and density functional theory calculations. Gd-Sc mixed-metal cluster fullerenes in carbon cages different from C80 were described for the first time. A review of their structures, properties, and stability is given. The synthesis was performed with melamine as an effective solid source of nitrogen, providing high fullerene yield and suppressing empty fullerene formation. Substitution of gadolinium by scandium imposes a noticeable influence on the electronic structure of nitride cluster fullerenes as revealed by electrochemical, spectroscopic, and computational methods.

  6. Copper scandium zirconium phosphate

    DEFF Research Database (Denmark)

    Bond, Andrew David; Warner, Terence Edwin

    2013-01-01

    components. The [Sc(III)Zr(IV)(PO(4))(3)](2-) framework is composed of corner-sharing Sc/ZrO(6) octahedra and PO(4) tetrahedra. The Sc and Zr atoms are disordered on one atomic site on a crystallographic threefold axis. The P atom of the phosphate group lies on a crystallographic twofold axis. Nonframework...

  7. Synthesis and characterization of reduced scandium halide containing one- and two-dimensional metal bonded arrays. [Sc--ScCl3; Cs3Sc2Cl9; CsScCl3

    Energy Technology Data Exchange (ETDEWEB)

    Poeppelmeier, K.R.

    1978-08-01

    The stabilization effect of metal-metal bond formation on reduced scandium compounds was studied. The binary compounds Sc/sub 7/Cl/sub 12/, Sc/sub 5/Cl/sub 8/, Sc/sub 7/Cl/sub 10/ and ScCl were prepared by high temperature techniques and were characterized by single crystal x-ray diffraction. The respective metal arrays in these compounds can be viewed as fragments of scandium metal ranging from discrete six atom metal cluster species (Sc(Sc/sub 6/Cl/sub 12/)), through intermediate single and double infinite chain configurations ((ScCl/sub 2/)(Sc/sub 4/Cl/sub 6/)) and ((ScCl/sub 2/)(Sc/sub 6/Cl/sub 8/)) to double metal close-packed sheets (ScCl). The halogen atoms effectively isolate the clusters, chains and sheets by bonding face, edge or exo positions on the metal arrays. The common occurrence of isolated scandium (III) ions emphasizes that a minimum number of bonding electrons is required to stabilize what are formally anionic metal arrays. The distribution of the reduction electrons in these anisotropic materials was studied by magnetic susceptibility, EPR and uv-X photoelectron spectroscopy. The ternary compounds studied were Cs/sub 3/Sc/sub 2/Cl/sub 9/ and CsScCl/sub 3/. The anion-bridged metal chain of the hexagonal perovskite structure was found to stabilize scandium (II). CsScCl/sub 3/ was found to be grossly nonstoichiometric on the transition metal site and the effects of the mixed valence character were studied between the single valence extremes Cs/sub 3/Sc/sub 2 + x/Cl/sub 9/; 0< x < 1.0.

  8. 46 CFR 59.10-30 - Seal welding.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Seal welding. 59.10-30 Section 59.10-30 Shipping COAST... VESSELS AND APPURTENANCES Welding Repairs to Boilers and Pressure Vessels in -Service § 59.10-30 Seal welding. Where leaks occur in riveted joints or connections, they shall be carefully investigated to...

  9. 14 CFR 1260.59 - Choice of law.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Choice of law. 1260.59 Section 1260.59... Special Conditions § 1260.59 Choice of law. Choice of Law October 2000 The rights and obligations of the parties to the grant (or cooperative agreement) shall be ascertainable by recourse to the laws of the...

  10. 29 CFR 531.59 - The tip wage credit.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false The tip wage credit. 531.59 Section 531.59 Labor... § 531.59 The tip wage credit. In determining compliance with the wage payment requirements of the Act... such employee in the workweek for which the wage payment is made. This credit is in addition to any...

  11. 42 CFR 59.210 - Inventions or discoveries.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Inventions or discoveries. 59.210 Section 59.210... PLANNING SERVICES Grants for Family Planning Service Training § 59.210 Inventions or discoveries. Any grant.... Laboratory notes, related technical data, and information pertaining to inventions and discoveries shall be...

  12. 42 CFR 59.211 - Publications and copyright.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Publications and copyright. 59.211 Section 59.211... PLANNING SERVICES Grants for Family Planning Service Training § 59.211 Publications and copyright. Except as may otherwise be provided under the terms and conditions of the award, the grantee may copyright...

  13. 32 CFR 728.59 - Peace Corps beneficiaries.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Peace Corps beneficiaries. 728.59 Section 728.59... § 728.59 Peace Corps beneficiaries. (a) Potential beneficiaries. (1) Applicants for the Peace Corps. (2) Peace Corps Volunteers. (3) Minor children of a Peace Corps volunteer living with the volunteer. (b...

  14. 25 CFR 141.59 - Customer complaint procedures.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Customer complaint procedures. 141.59 Section 141.59... THE NAVAJO, HOPI AND ZUNI RESERVATIONS Enforcement Powers, Procedures and Remedies § 141.59 Customer complaint procedures. (a) Any customer of a licensee may file a complaint with the Commissioner alleging...

  15. 46 CFR 59.01-2 - Incorporation by reference.

    Science.gov (United States)

    2010-10-01

    ... Code”), 59.10-5; 59.10-10; and (4) ASME Boiler and Pressure Vessel Code, Section IX, Welding and Brazing Qualifications (1998) (“Section IX of the ASME Boiler and Pressure Vessel Code”), 59.10-5. ... Park Avenue, New York, NY 10016-5990: (1) 2001 ASME Boiler and Pressure Vessel Code, Section I, Rules...

  16. 38 CFR 59.3 - Federal Application Identifier.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Federal Application Identifier. 59.3 Section 59.3 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) GRANTS TO STATES FOR CONSTRUCTION OR ACQUISITION OF STATE HOMES § 59.3 Federal Application...

  17. 38 CFR 59.124 - Inspections, audits, and reports.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Inspections, audits, and reports. 59.124 Section 59.124 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) GRANTS TO STATES FOR CONSTRUCTION OR ACQUISITION OF STATE HOMES § 59.124 Inspections, audits, and...

  18. 38 CFR 59.90 - Line item adjustments to grants.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Line item adjustments to grants. 59.90 Section 59.90 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) GRANTS TO STATES FOR CONSTRUCTION OR ACQUISITION OF STATE HOMES § 59.90 Line item adjustments to...

  19. 38 CFR 59.80 - Amount of grant.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Amount of grant. 59.80 Section 59.80 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) GRANTS TO STATES FOR CONSTRUCTION OR ACQUISITION OF STATE HOMES § 59.80 Amount of grant. (a) The total cost of a...

  20. 38 CFR 59.20 - Initial application requirements.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Initial application requirements. 59.20 Section 59.20 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) GRANTS TO STATES FOR CONSTRUCTION OR ACQUISITION OF STATE HOMES § 59.20 Initial application...

  1. 38 CFR 59.60 - Additional application requirements.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Additional application requirements. 59.60 Section 59.60 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) GRANTS TO STATES FOR CONSTRUCTION OR ACQUISITION OF STATE HOMES § 59.60 Additional application...

  2. 38 CFR 59.4 - Decisionmakers, notifications, and additional information.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Decisionmakers, notifications, and additional information. 59.4 Section 59.4 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) GRANTS TO STATES FOR CONSTRUCTION OR ACQUISITION OF STATE HOMES § 59...

  3. 38 CFR 59.121 - Amendments to application.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Amendments to application. 59.121 Section 59.121 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) GRANTS TO STATES FOR CONSTRUCTION OR ACQUISITION OF STATE HOMES § 59.121 Amendments to...

  4. 38 CFR 59.122 - Withdrawal of application.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Withdrawal of application. 59.122 Section 59.122 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) GRANTS TO STATES FOR CONSTRUCTION OR ACQUISITION OF STATE HOMES § 59.122 Withdrawal of...

  5. 38 CFR 59.100 - Payment of grant award.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Payment of grant award. 59.100 Section 59.100 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) GRANTS TO STATES FOR CONSTRUCTION OR ACQUISITION OF STATE HOMES § 59.100 Payment of grant award...

  6. 38 CFR 59.10 - General requirements for a grant.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false General requirements for a grant. 59.10 Section 59.10 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) GRANTS TO STATES FOR CONSTRUCTION OR ACQUISITION OF STATE HOMES § 59.10 General requirements for...

  7. 38 CFR 59.70 - Award of grants.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Award of grants. 59.70 Section 59.70 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) GRANTS TO STATES FOR CONSTRUCTION OR ACQUISITION OF STATE HOMES § 59.70 Award of grants. (a) The Secretary, during...

  8. 40 CFR 205.59 - Recall of noncomplying vehicles.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recall of noncomplying vehicles. 205.59 Section 205.59 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.59 Recall...

  9. 21 CFR 7.59 - General industry guidance.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false General industry guidance. 7.59 Section 7.59 Food... POLICY Recalls (Including Product Corrections)-Guidance on Policy, Procedures, and Industry Responsibilities § 7.59 General industry guidance. A recall can be disruptive of a firm's operation and business...

  10. 37 CFR 2.59 - Filing substitute specimen(s).

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Filing substitute specimen(s). 2.59 Section 2.59 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Drawing § 2.59 Filing substitute specimen(s). (a...

  11. 29 CFR 18.59 - Certification of official record.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Certification of official record. 18.59 Section 18.59 Labor... OFFICE OF ADMINISTRATIVE LAW JUDGES General § 18.59 Certification of official record. Upon timely receipt... with the reviewing authority, appellate body, or appropriate United States District Court, a full, true...

  12. 49 CFR 236.59 - Insulated rail joints.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Insulated rail joints. 236.59 Section 236.59 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION...: All Systems Track Circuits § 236.59 Insulated rail joints. Insulated rail joints shall be maintained...

  13. 36 CFR 7.59 - Grand Portage National Monument.

    Science.gov (United States)

    2010-07-01

    ... Monument. 7.59 Section 7.59 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.59 Grand Portage National Monument. (a... routes within the National Monument: (1) The trail from County Road 73 (near the Grand Portage Trading...

  14. Scandium functionalized carbon aerogel: Synthesis of nanoparticles and structure of a new ScOCl and properties of NaAlH{sub 4} as a function of pore size

    Energy Technology Data Exchange (ETDEWEB)

    Javadian, Payam; Nielsen, Thomas K. [Center for Energy Materials, Interdisciplinary Nanoscience Center (iNANO), and Department of Chemistry, Aarhus University, DK-8000 Aarhus (Denmark); Ravnsbæk, Dorthe B. [Department of Material Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge 02142, MA (United States); Jepsen, Lars H. [Center for Energy Materials, Interdisciplinary Nanoscience Center (iNANO), and Department of Chemistry, Aarhus University, DK-8000 Aarhus (Denmark); Polanski, Marek [Faculty of Advanced Technology and Chemistry, Military University of Technology, 2 Kaliskiego Str., 00-908 Warsaw (Poland); Plocinski, Tomasz [Faculty of Material Science and Engineering, Warsaw University of Technology, 144 Woloska Str., 02-507 Warsaw (Poland); Kunce, Izabela [Faculty of Advanced Technology and Chemistry, Military University of Technology, 2 Kaliskiego Str., 00-908 Warsaw (Poland); Besenbacher, Flemming [Interdisciplinary Nanoscience Center (iNANO) and Department of Physics and Astronomy, Aarhus University, DK-8000 Aarhus C (Denmark); Bystrzycki, Jerzy [Faculty of Advanced Technology and Chemistry, Military University of Technology, 2 Kaliskiego Str., 00-908 Warsaw (Poland); Jensen, Torben R., E-mail: trj@chem.au.dk [Center for Energy Materials, Interdisciplinary Nanoscience Center (iNANO), and Department of Chemistry, Aarhus University, DK-8000 Aarhus (Denmark)

    2015-11-15

    A new method for scandium-functionalization of carbon aerogels forming nanoparticles of a new scandiumoxochloride, ScOCl is presented. Sodium aluminiumhydride, NaAlH{sub 4}, is successfully melt infiltrated into the nano porous scaffolds with pore sizes of D{sub max}=7, 10, 13, 21, 26 and 39 nm, containing scandium based nano particles (<2.9 wt%) confirmed by elemental analysis and scanning electron microscopy. A systematic study of hydrogen storage properties of the nano composite materials is presented. An aqueous solution of ScCl{sub 3} was initially infiltrated and formed nanoconfined [Sc(OH)(H{sub 2}O){sub 5}]{sub 2}Cl{sub 4}(H{sub 2}O){sub 2}, which transforms to nanoparticles of a new scandium oxochloride, ScOCl at 192 °C and to Sc{sub 2}O{sub 3} at 420 °C. ScOCl crystallizes in an orthorhombic unit cell a=3.4409(8), b=3.9613(6) and c=8.178(2) Å, space group Pmmn, and is built from layers of [ScO{sub 4}Cl{sub 2}] octahedra forming neutral ScOCl layers. Temperature programmed desorption mass spectroscopy shows slightly improved kinetics for release of hydrogen with decreasing pore size. Continuous cycling of hydrogen release and uptake measured by the Sieverts' method reveal a larger preserved hydrogen storage capacity for scandium-functionalized aerogel with the larger pores (39 nm). - Highlights: • New synthesis approach for nanoporous Sc-functionalization carbon aerogel (Sc-CA). • The new scandium oxochloride, ScOCl, structure is obtained. • NaAlH{sub 4} nanoconfined in Sc-CA with pores ranging between 7 nm

  15. The use of the erbium, chromium:yttrium-scandium-gallium-garnet laser in endodontic treatment: the results of an in vitro study.

    Science.gov (United States)

    Schoop, Ulrich; Goharkhay, Kawe; Klimscha, Johannes; Zagler, Manuela; Wernisch, Johann; Georgopoulos, Apostolos; Sperr, Wolfgang; Moritz, Andreas

    2007-07-01

    The use of the erbium, chromium:yttrium-scandium-gallium-garnet (Er,Cr:YSGG) laser has become accepted in the field of cavity preparation. The development of miniaturized and flexible fiber tips has allowed this device to be used in endodontics. The authors conducted an in vitro study to assess the effects of Er,Cr:YSGG laser irradiation on root canals. The authors inoculated root canals with two bacteria, laser irradiated them at two power settings and subjected them to a quantitative microbiological evaluation. They used scanning electron microscopy (SEM) to assess morphological changes in endodontically processed and laser-irradiated root canal walls. They measured temperature increases on the root surface to determine possible thermal side effects. The bacteriological evaluation revealed a disinfecting effect in the root dentin samples that was dependent on the output power but not specific for the bacterial species investigated. SEM showed the removal of the smear layer from the root canal walls and the exposure of dentinal tubules. The temperature rise during irradiation was moderate when standardized power settings were used. The Er,Cr:YSGG laser can be used to eliminate bacteria in root canals. It also effectively removes smear layer and debris from the canal wall. Practitioners can use the Er,Cr:YSGG laser to prepare root canals for endodontic therapy.

  16. Aluminum-Scandium Alloys: Material Characterization, Friction Stir Welding, and Compatibility With Hydrogen Peroxide (MSFC Center Director's Discretionary Fund Final Report, Proj. No. 04-14)

    Science.gov (United States)

    Lee, J. A.; Chen, P. S.

    2004-01-01

    This Technical Memorandum describes the development of several high-strength aluminum (Al) alloys that are compatible with hydrogen peroxide (H2O2) propellant for NASA Hypersonic-X (Hyper-X) vehicles fuel tanks and structures. The yield strengths for some of these Al-magnesium-based alloys are more than 3 times stronger than the conventional 5254-H112 Al alloy, while maintaining excellent H2O2 compatibility similar to class 1 5254 alloy. The alloy development strategy is to add scandium, zirconium, and other transitional metals with unique electrochemical properties, which will not act as catalysts, to decompose the highly concentrated 90 percent H2O2. Test coupons are machined from sheet metals for H2O2 long-term exposure testing and mechanical properties testing. In addition, the ability to weld the new alloys using friction stir welding has also been explored. The new high-strength alloys could represent an enabling material technology for Hyper-X vehicles, where flight weight reduction is a critical requirement.

  17. High-fluence and high-density treatment of perioral rhytides using a new, fractionated 2,790-nm ablative erbium-doped Yttrium Scandium Gallium Garnet Laser.

    Science.gov (United States)

    Ciocon, David H; Hussain, Mussarat; Goldberg, David J

    2011-06-01

    In this study, we evaluated the safety and efficacy of a novel 2,790-nm erbium-doped yttrium scandium gallium garnet (Er:YSGG) laser system for the treatment of facial photodamage and perioral wrinkles using a single-treatment, high-fluence, high-density protocol. Eleven female participants with Fitzpatrick skin types II to III and facial wrinkles underwent a single full-face fractional ablative treatment with a 2,790-nm Er:YSGG laser. Follow-up visits were completed at 1, 2, and 6 weeks 3 and 6 months. Quartile improvement scale (0-4) and Fitzpatrick wrinkle scores (1-9) were used for the assessments. Based on blinded photographic assessments, the mean difference in Fitzpatrick wrinkle scores for full face wrinkles was 1.5 ± 1.2 (a reduction from 6.6 to 5.1; paired t-test, p = .003). There was also a statistically significant mean reduction of 1.7 ± 1.3 in perioral wrinkle scores (from 6.7 to 5.0; p = .002). No serious adverse events were reported. A novel, fractionated, ablative 2,790-nm Er:YSGG laser can safely and effectively treat photodamage and perioral wrinkles in a single treatment using a high-fluence, high-density protocol. Cutera provided the equipment used in this study and funding to Dr. Goldberg. © 2011 by the American Society for Dermatologic Surgery, Inc.

  18. Impact of layer and substrate properties on the surface acoustic wave velocity in scandium doped aluminum nitride based SAW devices on sapphire

    Energy Technology Data Exchange (ETDEWEB)

    Gillinger, M., E-mail: manuel.gillinger@tuwien.ac.at; Knobloch, T.; Schneider, M.; Schmid, U. [Institute of Sensor and Actuator Systems, TU Wien, 1040 Vienna (Austria); Shaposhnikov, K.; Kaltenbacher, M. [Institute of Mechanics and Mechatronics, TU Wien, 1040 Vienna (Austria)

    2016-06-06

    This paper investigates the performance of surface acoustic wave (SAW) devices consisting of reactively sputter deposited scandium doped aluminum nitride (Sc{sub x}Al{sub 1-x}N) thin films as piezoelectric layers on sapphire substrates for wireless sensor or for RF-MEMS applications. To investigate the influence of piezoelectric film thickness on the device properties, samples with thickness ranging from 500 nm up to 3000 nm are fabricated. S{sub 21} measurements and simulations demonstrate that the phase velocity is predominantly influenced by the mass density of the electrode material rather than by the thickness of the piezoelectric film. Additionally, the wave propagation direction is varied by rotating the interdigital transducer structures with respect to the crystal orientation of the substrate. The phase velocity is about 2.5% higher for a-direction compared to m-direction of the sapphire substrate, which is in excellent agreement with the difference in the anisotropic Young's modulus of the substrate corresponding to these directions.

  19. Spin-dependent rectification in the C59N molecule

    Indian Academy of Sciences (India)

    2013-02-05

    Feb 5, 2013 ... Spin-dependent electron transport; C60 molecule; C59N molecule; rectification effect; tunnel magnetoresistance. PACS Nos 72.25.−b; 72.80.Rj; 73.40.Ei. 1. Introduction. The azafullerene, C59N, represents an exciting addition to the family of fullerene deriva- tives. In this molecule, a single carbon atom of ...

  20. 7 CFR 51.59 - Operations and operating procedures.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Operations and operating procedures. 51.59 Section 51.59 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL...

  1. 49 CFR 570.59 - Service brake system.

    Science.gov (United States)

    2010-10-01

    ... the following tests. (1) Roller-type or drive-on platform tests. The force applied by the brake on a... shall be tested on a drive-on platform, or a roller-type brake analyzer with the capability of measuring... 49 Transportation 6 2010-10-01 2010-10-01 false Service brake system. 570.59 Section 570.59...

  2. 46 CFR 59.10-25 - Stayed areas.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Stayed areas. 59.10-25 Section 59.10-25 Shipping COAST... areas. Welding repairs are permitted in staybolted areas or areas adequately stayed by other means so... located entirely within staybolted areas and shall not pass through the outer row of stays. ...

  3. 28 CFR 345.59 - Inmate performance pay.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Inmate performance pay. 345.59 Section... INDUSTRIES (FPI) INMATE WORK PROGRAMS Inmate Pay and Benefits § 345.59 Inmate performance pay. Inmate workers for FPI may also receive Inmate Performance Pay for participation in programs where this award is made...

  4. 42 CFR 1008.59 - Range of the advisory opinion.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Range of the advisory opinion. 1008.59 Section 1008... AUTHORITIES ADVISORY OPINIONS BY THE OIG Scope and Effect of OIG Advisory Opinions § 1008.59 Range of the advisory opinion. (a) An advisory opinion will state only the OIG's opinion regarding the subject matter of...

  5. 7 CFR 1753.59-1753.65 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false 1753.59-1753.65 Section 1753.59-1753.65 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE TELECOMMUNICATIONS SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Outside Plant Major Construction by Force Account...

  6. Spin-dependent rectification in the C59N molecule

    Indian Academy of Sciences (India)

    Permanent link: http://www.ias.ac.in/article/fulltext/pram/080/02/0327-0336. Keywords. Spin-dependent electron transport; C60 molecule; C59N molecule; rectification effect; tunnel magnetoresistance. ... Obvious rectification effect is observed in the C59 N molecule which is connected to the FM electrodes asymmetrically.

  7. 33 CFR 110.59 - Eastern Long Island, NY.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Eastern Long Island, NY. 110.59... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.59 Eastern Long Island, NY. (a) Huntington Harbor... adjacent to the easterly side of Centre Island, westerly of a line on range with Cold Spring Harbor Light...

  8. 18 CFR 367.59 - Additions and retirements of property.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Additions and retirements of property. 367.59 Section 367.59 Conservation of Power and Water Resources FEDERAL ENERGY... accounting for the retirement of amounts included in account 303, Miscellaneous intangible property (§ 367...

  9. 36 CFR 902.59 - Geological and geophysical information.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Geological and geophysical information. 902.59 Section 902.59 Parks, Forests, and Public Property PENNSYLVANIA AVENUE DEVELOPMENT... Geological and geophysical information. Any geological or geophysical information and data (including maps...

  10. Structure and temperature effects on Nd3+ spectra in polycrystalline mixed scandium aluminum garnets Y3ScxAl5-xO12

    Science.gov (United States)

    Lupei, A.; Lupei, V.; Hau, S.; Gheorghe, C.; Voicu, F.

    2015-09-01

    New spectroscopic data obtained from high resolution low temperature absorption and emission spectra of Nd3+ in mixed scandium aluminum garnets Y3ScxAl5-xO12 - (x = 0-2) translucent ceramics revealed transition dependent composition effects: modification of the shapes (Lorentz at x = 0 and 2, quasi-Gauss at x = 1, x-dependent asymmetric for other x values, with obvious multicenter structure for low x), widths and shifts of the lines. Nd3+ electronic structure dependence on structural changes with composition is analyzed in terms of nephelauxetic effect and maximum splitting of manifolds: Sc3+ co-doping reduces the nephelauxetic effect, and the increase of 4F3/2 splitting from 85 cm-1 (x = 0) to 98 cm-1 (x = 2) denotes the lowering of local symmetry. The multicenter structure and inhomogeneous broadening of Nd3+ lines is attributed to crystal field distributions determined by the random occupancy of the octahedral sites by Sc3+ and Al3+. For low x (0.2) the resolved two satellites S1, S2 that accompany Nd:YAG lines are correlated to anisotropic crystal field perturbations produced by the n.n. Sc3+ by analogy to those determined by Y3+-antisites (excess of Y3+ ions that enter in octahedral sites of the melt-grown YAG crystals). The temperature evolution of the Nd3+ spectral characteristics (line intensity, shift, broadening) in the 10-300 K range is analyzed in terms of thermal population of the Stark levels, of the effect on electron-phonon interaction and on lattice expansion. The relevance of the spectroscopic properties on the laser emission characteristics in these systems is discussed.

  11. Dissolved scandium, yttrium, and lanthanum in the surface waters of the North Atlantic: Potential use as an indicator of scavenging intensity

    Science.gov (United States)

    Till, C. P.; Shelley, R. U.; Landing, W. M.; Bruland, K. W.

    2017-08-01

    Recent work has begun to elucidate the biogeochemical cycling of scandium (Sc) in the open ocean, but so far no surface distribution data have been reported of dissolved Sc, and no basin-scale surface distributions have been reported of yttrium (Y) or lanthanum (La). This work presents basin-wide surface Sc, Y, and La data in a section across the North Atlantic subtropical gyre (2011 GEOTRACES GA03) and investigates the potential utility of these distributions. This work uses dissolved and aerosol concentration data for La and Sc to estimate their surface ocean residence times in both the center of the oligotrophic gyre and near the African coastline. This work additionally shows that the surface distribution of Sc in the North Atlantic correlates with the shape of the gyre as inferred by isotherm depth, with lower Sc concentrations at the gyre boundaries. This pattern suggests that Sc could be drawn down by the elevated particle flux at the gyre boundaries. In this case, Sc removal could be used as an indicator of scavenging intensity. In order to account for variable input of Sc to the surface ocean, we propose normalizing the Sc distribution to that of Y or La, which are much less particle reactive and are input via dust to the surface North Atlantic in constant ratios with Sc. Such normalization improves the correlation with isotherm depth. We propose that the variations in dissolved Y/Sc and La/Sc ratios may be due to preferential Sc scavenging and could therefore indicate scavenging intensity.

  12. On new ternary equiatomic scandium transition metal aluminum compounds ScTAl with T = Cr, Ru, Ag, Re, Pt, and Au

    Energy Technology Data Exchange (ETDEWEB)

    Radzieowski, Mathis; Janka, Oliver [Muenster Univ. (Germany). Inst. fuer Anorganische und Analytische Chemie; Benndorf, Christopher [Muenster Univ. (Germany). Inst. fuer Anorganische und Analytische Chemie; Muenster Univ. (Germany). Inst. fuer Physikalische Chemie; Haverkamp, Sandra [Muenster Univ. (Germany). Inst. fuer Physikalische Chemie; Eckert, Hellmut [Muenster Univ. (Germany). Inst. fuer Physikalische Chemie; University of Sao Paulo, Sao Carlos, SP (Brazil). Inst. of Physics

    2016-08-01

    The new equiatomic scandium transition metal aluminides ScTAl for T = Cr, Ru, Ag, Re, Pt, and Au were obtained by arc-melting of the elements followed by subsequent annealing for crystal growth. The samples were studied by powder and single crystal X-ray diffraction. The structures of three compounds were refined from single crystal X-ray diffractometer data: ScCrAl, MgZn{sub 2} type, P6{sub 3}/mmc, a = 525.77(3), c = 858.68(5) pm, R{sub 1} = 0.0188, wR{sub 2} = 0.0485, 204 F{sup 2} values, 13 variables, ScPtAl, TiNiSi type, Pnma, a = 642.83(4), b = 428.96(2), c = 754.54(5) pm, R{sub 1} = 0.0326, wR{sub 2} = 0.0458, 448 F{sup 2} values, 20 variables and ScAuAl, HfRhSn type, P anti 62c, a = 722.88(4), c = 724.15(4) pm, R{sub 1} = 0.0316, wR{sub 2} = 0.0653, 512 F{sup 2} values, 18 variables. Phase pure samples of all compounds were furthermore investigated by magnetic susceptibility measurements, and Pauli-paramagnetism but no superconductivity was observed down to 2.1 K for all of them. The local structural features and disordering phenomena have been characterized by {sup 27}Al and {sup 45}Sc magic angle spinning (MAS) and static NMR spectroscopic investigations.

  13. Treatment of infraorbital dark circles in atopic dermatitis with a 2790-nm erbium: yttrium scandium gallium garnet laser: a pilot study.

    Science.gov (United States)

    Park, Kui Young; Oh, In Young; Moon, Nam Ju; Seo, Seong Jun

    2013-04-01

    Although many Asian atopic patients have orbital darkening symptom and the demand to treat this condition is increasing, little has been reported in the literature on the treatment of infraorbital dark circles in atopic dermatitis. To evaluate the clinical efficacy and safety of 2790-nm erbium:yttrium scandium gallium garnet (Er:YSGG) laser therapy for reducing infraorbital dark circles in atopic dermatitis patients. Ten Korean patients over 21 year with mild atopic dermatitis and infraorbital dark circles were enrolled in this study. Patients who need active atopic dermatitis treatments are excluded because of the possibility of aggravation after laser treatment. They were treated for dark circles using a 2790-nm Er:YSGG laser. The treatment parameters were 1.8-2.2 J/cm² fluence, 6-mm spot size, and 0.3-ms pulse width with 10% overlap over the infraorbital areas once with a 4-week interval between treatments. Efficacy was assessed with a quartile grading score ranging from 0 to 5 by a blinded investigator, and the patients also documented their degree of satisfaction with the same grading score. All possible side effects were evaluated. The clinical assessment showed 74.5% (2.7) and 72.5% (2.5) improvements, and the patient satisfaction scale scores improved an average of 74% (2.4) and 71.5% (2.3) at 2 months and 4 months after treatment, respectively. There were no severe side effects or aggravation of atopic dermatitis. Our study suggests that 2790-nm Er:YSGG laser therapy can be effectively and safely used in the treatment of infraorbital dark circles in atopic dermatitis patients.

  14. The influence of cation ordering, oxygen vacancy distribution and proton siting on observed properties in ceramic electrolytes: the case of scandium substituted barium titanate.

    Science.gov (United States)

    Torino, Nico; Henry, Paul F; Knee, Christopher S; Bjørheim, Tor Svendsen; Rahman, Seikh M H; Suard, Emma; Giacobbe, Carlotta; Eriksson, Sten G

    2017-07-04

    The origin of the 2-order of magnitude difference in the proton conductivity of the hydrated forms of hexagonal and cubic oxygen deficient BaScxTi1-xO3-δ (x = 0.2 and x = 0.7) was probed using a combination of neutron diffraction and density functional theory techniques to support published X-ray diffraction, conductivity, thermogravimetric and differential scanning calorimetry studies. Cation ordering is found in the 6H structure type (space group P63/mmc) adopted by BaSc0.2Ti0.8O3-δ with scandium preferentially substituting in the vertex sharing octahedra (2a crystallographic site) and avoiding the face-sharing octahedra (4f site). This is coupled with oxygen vacancy ordering in the central plane of the face-sharing octahedra (O1 site). In BaSc0.7Ti0.3O3-δ a simple cubic perovskite (space group Pm3[combining macron]m) best represents the average structure from Rietveld analysis with no evidence of either cation ordering or oxygen vacancy ordering. Significant diffuse scattering is observed, indicative of local order. Hydration in both cases leads to complete filling of the available oxygen vacancies and permits definition of the proton sites. We suggest that the more localised nature of the proton sites in the 6H structure is responsible for the significantly lower proton conduction observed in the literature. Within the 6H structure type final model, proton diffusion requires a 3-step process via higher energy proton sites that are unoccupied at room temperature and is also likely to be anisotropic whereas the highly disordered cubic perovskite proton position allows 3-dimensional diffusion by well-described modes. Finally, we propose how this knowledge can be used to further materials design for ceramic electrolytes for proton conducting fuel cells.

  15. DETECTION AND ISOLATION OF CD59 FROM HUMAN SEMINAL PLASMA

    Directory of Open Access Journals (Sweden)

    A REZAIE

    2002-06-01

    Full Text Available Introduction. CD59 is one of the complement regulatory proteins (CRPs which exert inhibitory function by blocking the formation of C5b-9 complex or Membrane Attacks complex (MAC. Regarding the therapeutic role of CD59 in treatment of pathological effects in uncontrolled activation of complements system and its efficiency to overcome the hyper-acute rejection, CD59 was suggested for maintenance of transplanted organ. In this study We determined and isolated CD59 from seminal plasma. Methods. Six normospermic sample according to WHO standards were chosen. Plasma of samples was separated and to remove the postasomes, the seminal plama was ultra centrifuged. CD59 was detected by Dot-Blot using CD59 mAb (MEM43. The molecular weight and purity of protein was detected by SOS-PAGE method follwed by Westerm Blot. Results. Protein was present in the 6.5 ml and 15ml of gel fitration fractions. Molecular weight based on marker size in these two fractions was 65 and 21KD respectively. Discussion. CD59 had previously beem purified by lysis of erythrocyte cell membrane. Because of use of detergent and preservative agents, this method decreased physiologic effects of the protein. In this study the isolation was performed from prostasome granules" without using of any detergent and preservative agents.

  16. Detection of {sup 59}Ni by accelerator mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Persson, Per; Erlandsson, Bengt; Freimann, K.; Hellborg, R.; Stenstroem, K. [Lund Univ. (Sweden). Dept. of Nuclear Physics; Larsson, Ragnar [Lund Univ. (Sweden). Chemical Engineering II; Skog, G. [Lund Univ. (Sweden). Dept. of Quaternary Geology

    1999-02-01

    The aims of this project were to develop a method to measure the amount of {sup 59}Ni in stainless steel and to determine the detection limit for this method. {sup 59}Ni is produced by neutron activation in the construction material close to the core in a nuclear reactor and it is important to know the amount of {sup 59}Ni present as it governs the classification of the waste. If the amount of {sup 59}Ni is known at different locations in relation to the core, it is also possible to refine the calculation models of the neutron flux in the reactor. Accelerator mass spectrometry, an ultra-sensitive method for measuring small concentrations of radionuclides as well as stable nuclides, has been used in this investigation to determine the concentration of {sup 59}Ni (and thereby the activity) in stainless steel. As the cobalt content in stainless steel is the main contributor to the background in a measurement of {sup 59}Ni, a method for the chemical extraction of nickel from stainless steel, including a purification step to reduce the cobalt content in the sample, has been developed. The detection limit for {sup 59}Ni has been determined to 100{+-}30 Bq per gram nickel (100{+-}30 Bq/g) with the present status of the system 14 refs, 6 figs, 3 tabs

  17. 47 CFR 76.59 - Modification of television markets.

    Science.gov (United States)

    2010-10-01

    ... MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Carriage of Television Broadcast Signals § 76.59 Modification... be included to support a technical service exhibit. (3) Available data on shopping and labor patterns...

  18. 59th Medical Wing Protection of Vulnerable Populations: Ombudsman Program

    Science.gov (United States)

    2018-04-20

    REPORT TYPE 20/04/2018 poster 4. TITLE AND SUBTITLE 59th Medical Wing Protection of Vulnerable Populations: Ombudsman Program 6. AUTHOR(S...CONTRACT NUMBER Sb. GRANT NUMBER Sc. PROGRAM ELEMENT NUMBER Sd. PROJECT NUMBER Se. TASK NUMBER Sf. WORK UNIT NUMBER 8. PERFORMING ORGANIZATION...59th Medical Wing Protection of Vulnerable Populations: Ombudsman Program Wayne DeutschDDS1, MPH, Michele Tavish LYN, PMP, CCRC 1 Brenda

  19. 24 CFR 983.59 - PHA-owned units.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false PHA-owned units. 983.59 Section 983... PROJECT-BASED VOUCHER (PBV) PROGRAM Selection of PBV Owner Proposals § 983.59 PHA-owned units. (a) Selection of PHA-owned units. The selection of PHA-owned units must be done in accordance with § 983.51(e...

  20. Effects of erbium-and chromium-doped yttrium scandium gallium garnet and diode lasers on the surfaces of restorative dental materials: a scanning electron microscope study.

    Science.gov (United States)

    Hatipoglu, M; Barutcigil, C

    2015-01-01

    The aim of this study is to evaluate the potential effects of laser irradiation, which is commonly performed in periodontal surgery, on the surfaces of restorative materials. Five different restorative dental materials were used in this study, as follows: (1) Resin composite, (2) poly acid-modified resin composite (compomer), (3) conventional glass ionomer cement (GIC), (4) resin-modified glass ionomer cement (RMGIC), and (5) amalgam. Four cylindrical samples (8 mm diameter, 2 mm height) were prepared for each restorative material. In addition, four freshly extracted, sound human incisors teeth were selected. Two different laser systems commonly used in periodontal surgery were examined in this study: A 810 nm diode laser at a setting of 1 W with continuous-phase laser irradiation for 10 s, and an erbium-and chromium-doped yttrium scandium gallium garnet (Er, Cr: YSGG) laser at settings of 2.5 W, 3.25 W, and 4 W with 25 Hz laser irradiation for 10 s. Scanning electron microscopy (SEM) analysis was performed to evaluate the morphology and surface deformation of the restorative materials and tooth surfaces. According to the SEM images, the Er, Cr: YSGG laser causes irradiation markings that appear as demineralized surfaces on tooth samples. The Er, Cr: YSGG laser also caused deep defects on composite, compomer, and RMGIC surfaces because of its high power, and the ablation was deeper for these samples. High-magnification SEM images of GIC samples showed the melting and combustion effects of the Er, Cr: YSGG laser, which increased as the laser power was increased. In amalgam samples, neither laser left significant harmful effects at the lowest power setting. The diode laser did cause irradiation markings, but they were insignificant compared with those left by the Er, Cr: YSGG laser on the surfaces of the different materials and teeth. Within the limitations of this study, it can be concluded that Er, Cr: YSGG laser irradiation could cause distortions of the surfaces

  1. Joint Force Quarterly. Issue 59, 4th Quarter 2010

    Science.gov (United States)

    2010-10-01

    JFQ NO T e S 1 Carlo D’ Este, Eisenhower: A Soldier’s Life (New York: Holt and Co., 2002), 693. 2 John R. Deni, Alliance Management and...Director of DOD Force Structure brief press on QDR and Ballistic Missile Defense Review DOD (Cherie Cullen ) ndupress .ndu.edu issue 59, 4 th quarter...Iraq commander GEN Odierno  updates press on state of affairs in Iraq DOD (Cherie Cullen ) ndupress .ndu.edu issue 59, 4 th quarter 2010 / JFQ

  2. 14 CFR 1260.59A - Invention reporting and rights.

    Science.gov (United States)

    2010-01-01

    ... operation thereof. (c) Reporting shall be made on NASA Form 1679 Disclosure of Invention and New Technology..., and interest in and to each such invention throughout the world. ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Invention reporting and rights. 1260.59A...

  3. STEM Education Act of 2015 (Public Law 114-59)

    Science.gov (United States)

    US Congress, 2015

    2015-01-01

    The STEM Education Act of 2015 (Public Law 114-59) was put in place to define Science Technology Engineering and Mathematics (STEM) education to include computer science, and to support existing STEM education programs at the National Science Foundation. The act is organized into the following sections: (1) Short Title; (2) Definition of STEM…

  4. 40 CFR 59.209 - Recordkeeping and reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... submitted to the Administrator a written certification that the manufacturer or importer will maintain the... and review. (1) Records or formulations being manufactured or imported on or after December 10, 1998..., 1998 for all consumer products subject to § 59.203(a) or December 10, 1999 for all consumer products...

  5. 42 CFR 59.206 - Evaluation and grant award.

    Science.gov (United States)

    2010-10-01

    ... their own staffs; (ii) Improvement of the family planning services delivery skills of family planning... PLANNING SERVICES Grants for Family Planning Service Training § 59.206 Evaluation and grant award. (a... family planning services; (2) The extent to which the training program promises to fulfill the family...

  6. 42 CFR 410.59 - Outpatient occupational therapy services: Conditions.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Outpatient occupational therapy services... Other Health Services § 410.59 Outpatient occupational therapy services: Conditions. (a) Basic rule... occupational therapy services only if they are furnished by an individual meeting the qualifications in part...

  7. Sample Set (SE): SE59 [Metabolonote[Archive

    Lifescience Database Archive (English)

    Full Text Available idopsis thaliana (Arabidopsis). However, the behavior of flavonoids during drough...t stress is still not well documented. Herein we investigated the time-series alternation of flavonoids in t...vonoids, a class of specialized metabolites, including flavonols and anthocyanins w...SE59 Alternation of flavonoid accumulation under drought stress in Arabidopsis thaliana We reported that fla

  8. 6 CFR 37.59 - DHS reviews of State compliance.

    Science.gov (United States)

    2010-01-01

    ... 37.59 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY REAL ID DRIVER'S... Compliance Checklist or State certification documentation of full compliance pursuant to § 37.55. (1) If DHS determines that the State meets the benchmarks of the Material Compliance Checklist, DHS may grant the State...

  9. Sample Preparation (SS): SE59_SS01 [Metabolonote[Archive

    Lifescience Database Archive (English)

    Full Text Available SE59_SS01 Drought stress Three-week-old plants vertically grown on GM plates were i...ncubated in 24-well plates (TPP, http://www.tpp.ch/index.php). Each plant was put in a well with 3 ml water. Three

  10. Sample (S): SE59_S01 [Metabolonote[Archive

    Lifescience Database Archive (English)

    Full Text Available SE59_S01 Arabidopsis Arabidopsis thaliana NCBI taxonomy:3702 Arabidopsis (Col-0) pl...ants were used in this study. All plates were placed in a growth chamber at 22 °C with a relative humidity o

  11. 38 CFR 59.150 - Domiciliary care requirements.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Domiciliary care... (CONTINUED) GRANTS TO STATES FOR CONSTRUCTION OR ACQUISITION OF STATE HOMES § 59.150 Domiciliary care requirements. As a condition for receiving a grant and grant funds for a domiciliary under this part, the...

  12. Phenotype-gene: 59 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 59 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1058i decreased efficiency...:433-44. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17329563i decreased efficiency during pro

  13. AS03- and MF59-Adjuvanted Influenza Vaccines in Children

    Directory of Open Access Journals (Sweden)

    Amanda L. Wilkins

    2017-12-01

    Full Text Available Influenza is a major cause of respiratory disease leading to hospitalization in young children. However, seasonal trivalent influenza vaccines (TIVs have been shown to be ineffective and poorly immunogenic in this population. The development of live-attenuated influenza vaccines and adjuvanted vaccines are important advances in the prevention of influenza in young children. The oil-in-water emulsions MF59 and adjuvant systems 03 (AS03 have been used as adjuvants in both seasonal adjuvanted trivalent influenza vaccines (ATIVs and pandemic monovalent influenza vaccines. Compared with non-adjuvanted vaccine responses, these vaccines induce a more robust and persistent antibody response for both homologous and heterologous influenza strains in infants and young children. Evidence of a significant improvement in vaccine efficacy with these adjuvanted vaccines resulted in the use of the monovalent (A/H1N1 AS03-adjuvanted vaccine in children in the 2009 influenza pandemic and the licensure of the seasonal MF59 ATIV for children aged 6 months to 2 years in Canada. The mechanism of action of MF59 and AS03 remains unclear. Adjuvants such as MF59 induce proinflammatory cytokines and chemokines, including CXCL10, but independently of type-1 interferon. This proinflammatory response is associated with improved recruitment, activation and maturation of antigen presenting cells at the injection site. In young children MF59 ATIV produced more homogenous and robust transcriptional responses, more similar to adult-like patterns, than did TIV. Early gene signatures characteristic of the innate immune response, which correlated with antibody titers were also identified. Differences were detected when comparing child and adult responses including opposite trends in gene set enrichment at day 3 postvaccination and, unlike adult data, a lack of correlation between magnitude of plasmablast response at day 7 and antibody titers at day 28 in children. These insights

  14. AS03- and MF59-Adjuvanted Influenza Vaccines in Children

    Science.gov (United States)

    Wilkins, Amanda L.; Kazmin, Dmitri; Napolitani, Giorgio; Clutterbuck, Elizabeth A.; Pulendran, Bali; Siegrist, Claire-Anne; Pollard, Andrew J.

    2017-01-01

    Influenza is a major cause of respiratory disease leading to hospitalization in young children. However, seasonal trivalent influenza vaccines (TIVs) have been shown to be ineffective and poorly immunogenic in this population. The development of live-attenuated influenza vaccines and adjuvanted vaccines are important advances in the prevention of influenza in young children. The oil-in-water emulsions MF59 and adjuvant systems 03 (AS03) have been used as adjuvants in both seasonal adjuvanted trivalent influenza vaccines (ATIVs) and pandemic monovalent influenza vaccines. Compared with non-adjuvanted vaccine responses, these vaccines induce a more robust and persistent antibody response for both homologous and heterologous influenza strains in infants and young children. Evidence of a significant improvement in vaccine efficacy with these adjuvanted vaccines resulted in the use of the monovalent (A/H1N1) AS03-adjuvanted vaccine in children in the 2009 influenza pandemic and the licensure of the seasonal MF59 ATIV for children aged 6 months to 2 years in Canada. The mechanism of action of MF59 and AS03 remains unclear. Adjuvants such as MF59 induce proinflammatory cytokines and chemokines, including CXCL10, but independently of type-1 interferon. This proinflammatory response is associated with improved recruitment, activation and maturation of antigen presenting cells at the injection site. In young children MF59 ATIV produced more homogenous and robust transcriptional responses, more similar to adult-like patterns, than did TIV. Early gene signatures characteristic of the innate immune response, which correlated with antibody titers were also identified. Differences were detected when comparing child and adult responses including opposite trends in gene set enrichment at day 3 postvaccination and, unlike adult data, a lack of correlation between magnitude of plasmablast response at day 7 and antibody titers at day 28 in children. These insights show the utility

  15. Influence of c-axis orientation and scandium concentration on infrared active modes of magnetron sputtered Sc{sub x}Al{sub 1−x}N thin films

    Energy Technology Data Exchange (ETDEWEB)

    Mayrhofer, P. M.; Bittner, A.; Schmid, U. [Institute of Sensor and Actuator Systems, Vienna University of Technology, Floragasse 7, 1040 Vienna (Austria); Eisenmenger-Sittner, C. [Institute of Solid State Physics, Vienna University of Technology, Wiedner Hauptstrasse 8, 1040 Vienna (Austria); Euchner, H. [Institute of Materials Science and Technology, Vienna University of Technology, Karlsplatz 13, 1040 Vienna (Austria)

    2013-12-16

    Doping of wurtzite aluminium nitride (AlN) with scandium (Sc) significantly enhances the piezoelectric properties of AlN. Sc{sub x}Al{sub 1−x}N thin films with different Sc concentrations (x = 0 to 0.15) were deposited by DC reactive magnetron sputtering. Infrared (IR) absorbance spectroscopy was applied to investigate the Sc concentration dependent shift of the IR active modes E{sub 1}(TO) and A{sub 1}(TO). These results are compared to ab initio simulations, being in excellent agreement with the experimental findings. In addition, IR spectroscopy is established as an economical and fast method to distinguish between thin films with a high degree of c-axis orientation and those exhibiting mixed orientations.

  16. The trigger and DAQ systems of the NA59 experiment

    CERN Document Server

    Ünel, Gokhan; Ballestrero, Sergio

    2004-01-01

    The NA59 experiment on the CERN SPS-H2 beam-line took data during the summers of 1999 and 2000 to perform intercalibration studies of polarization measurement and to test the use of an aligned crystal as a quarter-wave plate. The analysis revealed a proof of concept for the birefringence property of aligned crystals for photons in the 30-170 GeV energy range. The 90-m-long detector for this fixed target experiment had two independent readout schemes: one for more than 120 time-to-digital and analog-to-digital converter channels to obtain tracking and energy information; and another for the readout of the silicon strip detectors to improve vertex resolution. The readout electronics of the Na59 experiment was based on VMEbus and CAMAC systems. Novel data acquisition and online monitoring software were written to work on the commodity hardware (PCs) running mainly the Linux operating system. 21 Refs.

  17. Two scandium-biuret complexes: [Sc(C2H5N3O2)(H2O)5]Cl3 x H2O and [Sc(C2H5N3O2)4](NO3)3.

    Science.gov (United States)

    Harrison, William T A

    2008-05-01

    The scandium(III) cations in the structures of pentaaqua(biuret-kappa(2)O,O')scandium(III) trichloride monohydrate, [Sc(C(2)H(5)N(3)O(2))(H(2)O)(5)]Cl(3) x H(2)O, (I), and tetrakis(biuret-kappa(2)O,O')scandium(III) trinitrate, [Sc(C(2)H(5)N(3)O(2))(4)](NO(3))(3), (II), are found to adopt very different coordinations with the same biuret ligand. The roles of hydrogen bonding and the counter-ion in the establishment of the structures are described. In (I), the Sc(3+) cation adopts a fairly regular pentagonal bipyramidal coordination geometry arising from one O,O'-bidentate biuret molecule and five water molecules. A dense network of N-H...Cl, O-H...O and O-H...Cl hydrogen bonds help to establish the packing, resulting in dimeric associations of two cations and two water molecules. In (II), the Sc(3+) cation (site symmetry 2) adopts a slightly squashed square-antiprismatic geometry arising from four O,O'-bidentate biuret molecules. A network of N-H...O hydrogen bonds help to establish the packing, which features [010] chains of cations. One of the nitrate ions is disordered about an inversion centre. Both structures form three-dimensional hydrogen-bond networks.

  18. Upper lip malignant neoplasms. A study of 59 cases.

    Science.gov (United States)

    Luna-Ortiz, Kuauhyama; Güemes-Meza, Agustín; Villavicencio-Valencia, Verónica; Mosqueda-Taylor, Adalberto

    2012-05-01

    To present the demographic data, clinico-pathologic features and therapeutic outcome of a series of upper lip malignancies. Retrospective study at a single Cancer Institution in Mexico City during a 14-year period. There were 59 cases, (30 males and 29 females); age range: 14 to 106 years (mean: 73 yr.). Antecedents of ultraviolet light and tobacco exposure were found in 20 (33.9%) and 16 cases (27%) respectively. There were 35 squamous cell carcinomas (59.3%), 19 basal cell carcinomas (32.2%) and one case each (1.7%) of adenocarcinoma NOS, adenoid cystic carcinoma, angiosarcoma, Merkel cell carcinoma and melanoma. There were 14 cases in stage I (23.7%), 14 in stage II (23.7%), 3 in stage III (5.1%) 14 in stage IV (23.7%) and 14 were not classified (23.7%). There were no significant differences with respect to the overall survival curve and the disease-free survival curve among surgical treatment and radiotherapy. In addition, there was not statistically significant difference in the overall survival and disease-free survival among squamous cell carcinoma and basal cell carcinoma cases with respect to the type of treatment. Upper lip malignant neoplasms are infrequent lesions. The present series describes the main clinico-pathological features in a hospital-based population in Mexico city and demonstrates some differences with respect to those found in the lower lip.

  19. Pneumonia tuberculosa: um estudo de 59 casos confirmados microbiologicamente Tuberculous pneumonia: a study of 59 microbiologically confirmed cases

    Directory of Open Access Journals (Sweden)

    Jose Moreira

    2011-04-01

    Full Text Available OBJETIVO: Estudar os aspectos clínicos, epidemiológicos, radiológicos e endoscópicos encontrados em indivíduos com pneumonia tuberculosa. MÉTODOS: Entre dezembro de 2005 e fevereiro de 2007, foram estudados 2.828 pacientes com tuberculose que foram consecutivamente atendidos em uma unidade de saúde pública. Desses, 59 (2,1% tiveram envolvimento pulmonar compatível com fístula entre um linfonodo e um brônquio. RESULTADOS: Dos 59 pacientes estudados, 43 (73% tinham entre 20 e 50 anos de idade, 31 (53% eram do sexo masculino, e 28 (47% eram negros. Os sintomas mais frequentes foram tosse (100%, febre (88%, expectoração (81% e perda de peso (40%. Comorbidades foram registradas em 35 pacientes (59%, especialmente a infecção por HIV (20% e diabetes (15%. Na radiografia de tórax, a consolidação predominou nos lobos superiores (em 68%. A confirmação diagnóstica (presença de BAAR foi feita principalmente por baciloscopia direta do escarro, seguida por broncoscopia (LBA e biópsia brônquica. Lesões brônquicas claramente indicativas ou sugestivas de fístula foram identificadas em três casos e cinco casos, respectivamente. CONCLUSÕES: A pneumonia tuberculosa apresenta-se como uma infecção respiratória aguda, com tosse seca seguida por febre. A radiografia de tórax mostra consolidação alveolar. Na maioria dos casos, a pneumonia tuberculosa foi acompanhada por pelo menos uma comorbidade, especialmente a infecção por HIV, e a confirmação etiológica foi obtida principalmente através do exame de escarro direto para BAAR. Os achados de broncoscopia foram indicativos de fístula brônquica em oito casos (13%.OBJECTIVE: To study the clinical, epidemiological, radiographic and endoscopic features of individuals with tuberculous pneumonia. METHODS: We evaluated 2,828 consecutive tuberculosis patients treated at a public health center between December of 2005 and February of 2007. Of those, 59 (2.1% had pulmonary involvement

  20. Trace elements in 59 mostly highland moon rocks

    Science.gov (United States)

    Ebihara, Mitsuru; Wolf, Rainer; Warren, Paul H.; Anders, Edward

    1992-01-01

    New chemical analyses for up to 26 trace elements, including seldom-determined highly siderophile elements Ir, Os, Re, Au, Pd, and Ge, for 59 lunar samples are reported. Most of these samples are polymict breccias from Apollo 16. Remarkably few have Group 7 (extremely low Au/Ir) meteoritic components. Several samples have uncommonly high Au/(Ir + Re) ratios, even higher than group 1L. Volatile-element enrichments are found in several fragments from rusty rock 66095. A matrix sample from fragmental breccia 60639 shows Cd and In enrichments, also observed previously in samples of anorthosite and mare basalt from the same breccia. Evidently, for these highly labile elements, chemical exchange has affected clasts that for most other elements are pristine.

  1. Young Cluster Berkeley 59: Properties, Evolution, and Star Formation

    Science.gov (United States)

    Panwar, Neelam; Pandey, A. K.; Samal, Manash R.; Battinelli, Paolo; Ogura, K.; Ojha, D. K.; Chen, W. P.; Singh, H. P.

    2018-01-01

    Berkeley 59 is a nearby (∼1 kpc) young cluster associated with the Sh2-171 H II region. We present deep optical observations of the central ∼2.5 × 2.5 pc2 area of the cluster, obtained with the 3.58 m Telescopio Nazionale Galileo. The V/(V–I) color–magnitude diagram manifests a clear pre-main-sequence (PMS) population down to ∼0.2 M ⊙. Using the near-infrared and optical colors of the low-mass PMS members, we derive a global extinction of A V = 4 mag and a mean age of ∼1.8 Myr, respectively, for the cluster. We constructed the initial mass function and found that its global slopes in the mass ranges of 0.2–28 M ⊙ and 0.2–1.5 M ⊙ are ‑1.33 and ‑1.23, respectively, in good agreement with the Salpeter value in the solar neighborhood. We looked for the radial variation of the mass function and found that the slope is flatter in the inner region than in the outer region, indicating mass segregation. The dynamical status of the cluster suggests that the mass segregation is likely primordial. The age distribution of the PMS sources reveals that the younger sources appear to concentrate close to the inner region compared to the outer region of the cluster, a phenomenon possibly linked to the time evolution of star-forming clouds. Within the observed area, we derive a total mass of ∼103 M ⊙ for the cluster. Comparing the properties of Berkeley 59 with other young clusters, we suggest it resembles more closely the Trapezium cluster.

  2. Photooxidation of olefins sensitized by bisazafullerene (C(59)N)(2) and hydroazafullerene C(59)HN: product analysis, emission of singlet oxygen, and transient absorption spectroscopy.

    Science.gov (United States)

    Tagmatarchis, N; Shinohara, H; Fujitsuka, M; Ito, O

    2001-11-30

    The photooxidation reactions of olefins sensitized by the excited triplet states of bisazafullerene (C(59)N)(2) and hydroazafullerene C(59)HN have been studied. Oxidation yields were compared with those of pristine C(60). The singlet oxygen yields are also determined directly from the emission intensities, which are in good agreement with the oxidation yields. The triplet states of (C(59)N)(2) and C(59)HN have been identified by the time-resolved spectroscopic method by observing the triplet-triplet absorption spectra, which decay in the presence of oxygen. It has been proven that (C(59)N)(2) and C(59)HN have the ability to sensitize the reactions via singlet oxygen in about half of the efficiency of that of pristine C(60). For both azafullerenes, the triplet lifetimes are shorter than that of pristine C(60), which may be related to the nitrogen atom embedded in the C(60) moiety.

  3. Tratamento cirúrgico dos insulinomas -- estudo de 59 casos Surgical treatment of insulinoma. Study of 59 cases

    Directory of Open Access Journals (Sweden)

    M.C.C. Machado

    1998-06-01

    Full Text Available Após a confirmação clínica e laboratorial de hiperinsulinismo, o principal problema consiste na localização precisa da lesão no parênquima pancreático, propiciando tratamento cirúrgico adequado. OBJETIVO: Analisar os métodos utilizados para o diagnóstico e localização pré e intra-operatório dos insulinomas, bem como as técnicas e os resultados do tratamento cirúrgico. MÉTODOS: Foram estudados 59 casos consecutivos de insulinoma submetidos a intervenção cirúrgica. Cada um dos métodos utilizados para a localização pré-operatória dessas lesões foi avaliado quanto à sua eficiência em confronto com os achados intra-operatórios. A palpação do pâncreas, isoladamente ou associada à ultra-sonografia intra-operatória, como métodos de localização dos insulinomas, foi também estudada. Os tipos de intervenção cirúrgica foram analisados quanto aos seus resultados imediatos e tardios. RESULTADOS: Dos 59 insulinomas, 55 eram benignos e quatro, malignos. Dos métodos utilizados para a localização pré-operatória, a ultra-sonografia foi eficiente em 28,1% dos casos, a tomografia computadorizada em 25%, a ultra-sonografia endoscópica em 27,2%, a arteriografia seletiva em 54,1% e a colheita de amostras de sangue portal para dosagem de insulina em 94,4% dos casos. A palpação bidigital, durante a intervenção cirúrgica, localizou as lesões em 54/55 casos (98,2%. A ultra-sonografia intra-operatória foi decisiva em apenas um caso. Cinco doentes apresentavam neoplasia endócrina múltipla tipo I e em todos as lesões pancreáticas eram múltiplas. Foram efetuadas 29 enucleações e 32 ressecções pancreáticas nos doentes com lesões benignas. Os doentes com lesões malignas foram submetidos a ressecções pancreáticas e quimioterapia. Não houve mortalidade, porém observaram-se complicações (fístulas em 29/59 casos. Os resultados foram bons em 98,1% dos doentes com lesões benignas. Apenas um dos doentes com

  4. 46 CFR 59.10-20 - Patches in shells and tube sheets.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Patches in shells and tube sheets. 59.10-20 Section 59... § 59.10-20 Patches in shells and tube sheets. (a) Unreinforced openings in the shells or drums of... inside the drum or shell and sealed against leakage by welding. Such plates shall have a diameter of at...

  5. 44 CFR 59.22 - Prerequisites for the sale of flood insurance.

    Science.gov (United States)

    2010-10-01

    ... flood insurance. 59.22 Section 59.22 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program GENERAL PROVISIONS Eligibility Requirements § 59.22 Prerequisites for the sale of flood insurance. (a) To...

  6. 7 CFR 2.59 - Deputy Under Secretaries for Natural Resources and Environment.

    Science.gov (United States)

    2010-01-01

    ... Environment. 2.59 Section 2.59 Agriculture Office of the Secretary of Agriculture DELEGATIONS OF AUTHORITY BY... Under Secretary for Natural Resources and Environment § 2.59 Deputy Under Secretaries for Natural Resources and Environment. Pursuant to § 2.20(a), subject to reservations in § 2.20(b), and subject to...

  7. 38 CFR 59.5 - Submissions of information and documents to VA.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Submissions of information and documents to VA. 59.5 Section 59.5 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) GRANTS TO STATES FOR CONSTRUCTION OR ACQUISITION OF STATE HOMES § 59.5...

  8. 38 CFR 59.130 - General requirements for all State home facilities.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false General requirements for all State home facilities. 59.130 Section 59.130 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) GRANTS TO STATES FOR CONSTRUCTION OR ACQUISITION OF STATE HOMES § 59.130...

  9. 10 CFR 32.59 - Same: Leak testing of each source.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Same: Leak testing of each source. 32.59 Section 32.59 Energy NUCLEAR REGULATORY COMMISSION SPECIFIC DOMESTIC LICENSES TO MANUFACTURE OR TRANSFER CERTAIN ITEMS CONTAINING BYPRODUCT MATERIAL Generally Licensed Items § 32.59 Same: Leak testing of each source. Each person...

  10. 37 CFR 11.59 - Dissemination of disciplinary and other information.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Dissemination of disciplinary and other information. 11.59 Section 11.59 Patents, Trademarks, and Copyrights UNITED STATES PATENT..., Investigations, and Proceedings § 11.59 Dissemination of disciplinary and other information. (a) The OED Director...

  11. 40 CFR 59.621 - Who may apply for a certificate of conformity?

    Science.gov (United States)

    2010-07-01

    ... conformity? 59.621 Section 59.621 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Families § 59.621 Who may apply for a certificate of conformity? A certificate of conformity may be issued... certificate of conformity. However, in order to hold the certificate, the manufacturer must demonstrate day-to...

  12. Production of human CD59-transgenic pigs by embryonic germ cell nuclear transfer

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Kwang Sung; Won, Ji Young [Department of Physiology, Dankook University School of Medicine, Cheonan (Korea, Republic of); Park, Jin-Ki [Animal Biotechnology Division, National Institute of Animal Science, Suwon (Korea, Republic of); Sorrell, Alice M. [Department of Physiology, Dankook University School of Medicine, Cheonan (Korea, Republic of); Heo, Soon Young; Kang, Jee Hyun [Department of Nanobiomedical Science, Dankook University, Cheonan (Korea, Republic of); Woo, Jae-Seok [Animal Biotechnology Division, National Institute of Animal Science, Suwon (Korea, Republic of); Choi, Bong-Hwan [Genomics and Bioinformatics Division, National Institute of Animal Science, Suwon (Korea, Republic of); Chang, Won-Kyong [Animal Biotechnology Division, National Institute of Animal Science, Suwon (Korea, Republic of); Shim, Hosup, E-mail: shim@dku.edu [Department of Nanobiomedical Science, Dankook University, Cheonan (Korea, Republic of); Institute of Tissue Regeneration Engineering, Dankook University, Cheonan (Korea, Republic of)

    2010-10-01

    Research highlights: {yields} Human CD59 (hCD59) gene was introduced into porcine embryonic germ (EG) cells. {yields} hCD59-transgenic EG cells were resistant to hyperacute rejection in cytolytic assay. {yields} hCD59-transgenic pigs were produced by EG cell nuclear transfer. -- Abstract: This study was performed to produce transgenic pigs expressing the human complement regulatory protein CD59 (hCD59) using the nuclear transfer (NT) of embryonic germ (EG) cells, which are undifferentiated stem cells derived from primordial germ cells. Because EG cells can be cultured indefinitely in an undifferentiated state, they may provide an inexhaustible source of nuclear donor cells for NT to produce transgenic pigs. A total of 1980 NT embryos derived from hCD59-transgenic EG cells were transferred to ten recipients, resulting in the birth of fifteen piglets from three pregnancies. Among these offspring, ten were alive without overt health problems. Based on PCR analysis, all fifteen piglets were confirmed as hCD59 transgenic. The expression of the hCD59 transgene in the ten living piglets was verified by RT-PCR. Western analysis showed the expression of the hCD59 protein in four of the ten RT-PCR-positive piglets. These results demonstrate that hCD59-transgenic pigs could effectively be produced by EG cell NT and that such transgenic pigs may be used as organ donors in pig-to-human xenotransplantation.

  13. Sequestration of host-CD59 as potential immune evasion strategy of Trichomonas vaginalis.

    Science.gov (United States)

    Ibáñez-Escribano, Alexandra; Nogal-Ruiz, Juan José; Pérez-Serrano, Jorge; Gómez-Barrio, Alicia; Escario, J Antonio; Alderete, J F

    2015-09-01

    Trichomonas vaginalis is known to evade complement-mediated lysis. Because the genome of T. vaginalis does not possess DNA sequence with homology to human protectin (CD59), a complement lysis restricting factor, we tested the hypothesis that host CD59 acquisition by T. vaginalis organisms mediates resistance to complement killing. This hypothesis was based on the fact that trichomonads are known to associate with host proteins. No CD59 was detected on the surface of T. vaginalis grown in serum-based medium using as probe anti-CD59 monoclonal antibody (MAb). We, therefore, infected mice intraperitoneally with live T. vaginalis, and trichomonads harvested from ascites were tested for binding of CD59. Immunofluorescence showed that parasites had surface CD59. Furthermore, as mouse erythrocytes (RBCs) possess membrane-associated CD59, and trichomonads use RBCs as a nutrient source, organisms were co-cultured with murine RBCs for one week. Parasites were shown to have detectable surface CD59. Importantly, live T. vaginalis with bound CD59 were compared with batch-grown parasites without surface-associated CD59 for sensitivity to complement in human serum. Trichomonads without surface-bound CD59 had a higher level of killing by complement than did parasites with surface CD59. These data show that host CD59 acquired onto the surface by live T. vaginalis may be an alternative mechanism for complement evasion. We describe a novel strategy by T. vaginalis consistent with host protein procurement by this parasite to evade the lytic action of complement. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. Preparation and biodistribution of {sup 59}Fe-radiolabelled iron oxide nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Pospisilova, Martina, E-mail: martinapospisilova@gmail.com; Zapotocky, Vojtech; Nesporova, Kristina [Contipro a.s (Czech Republic); Laznicek, Milan; Laznickova, Alice [Charles University, Faculty of Pharmacy in Hradec Králové (Czech Republic); Zidek, Ondrej; Cepa, Martin; Vagnerova, Hana; Velebny, Vladimir [Contipro a.s (Czech Republic)

    2017-02-15

    We report on the {sup 59}Fe radiolabelling of iron oxide nanoparticle cores through post-synthetic isotope exchange ({sup 59}Fe-IONP{sub ex}) and precursor labelling ({sup 59}Fe-IONP{sub pre}). Scanning electron microscopy and dynamic light scattering measurements showed no impact of radiolabelling on nanoparticle size or morphology. While incorporation efficiencies of these methods are comparable—83 and 90% for precursor labelling and post-synthetic isotope exchange, respectively—{sup 59}Fe-IONP{sub pre} exhibited much higher radiochemical stability in citrated human plasma. Quantitative ex vivo biodistribution study of {sup 59}Fe-IONP{sub pre} coated with triethylene glycol was performed in Wistar rats. Following the intravenous administration, high {sup 59}Fe concentration was observed in the lung and the organs of the reticuloendothelial system such as the liver, the spleen and the femur.

  15. 59th Medical Wing Clinical Research Division Clinical Investigations Program Pathology Poster

    Science.gov (United States)

    2017-04-28

    MDW staff member, we can forward your request for funds to the designated Wing POC at the Chief Scientist’s Office, Ms. Alice Houy, office phone: 210...DEPARTMENT OF THE AIR FORCE 59TH MEDICAL WING (AETC) JOINT BASE SAN ANTONIO - LACKLAND TEXAS 28 APR 2017 MEMORANDUM FORSGVU ATTN: JOSHUA CALCOTE FROM...59 MDW/SGVU SUBJECT: Professional Presentation Approval 1. Your paper, entitled 59th Medical Wing Clinical Research Division Clinical Investigations

  16. 46 CFR 59.20-1 - Carbon-steel or alloy-steel castings.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Carbon-steel or alloy-steel castings. 59.20-1 Section 59... BOILERS, PRESSURE VESSELS AND APPURTENANCES Welding Repairs to Castings § 59.20-1 Carbon-steel or alloy-steel castings. Defects in carbon-steel or alloy-steel castings may be repaired by welding. The repairs...

  17. 49 CFR 174.59 - Marking and placarding of rail cars.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Marking and placarding of rail cars. 174.59... RAIL General Handling and Loading Requirements § 174.59 Marking and placarding of rail cars. No person may transport a rail car carrying hazardous materials unless it is marked and placarded as required by...

  18. 77 FR 27551 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-59; Small Entity Compliance Guide

    Science.gov (United States)

    2012-05-10

    ... Acquisition Regulation; Federal Acquisition Circular 2005-59; Small Entity Compliance Guide AGENCY: Department... Regulation (FAR). Interested parties may obtain further information regarding this rule by referring to FAC 2005-59, which precedes this document. These documents are also available via the Internet at http...

  19. 46 CFR 30.10-59 - Reid vapor pressure-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Reid vapor pressure-TB/ALL. 30.10-59 Section 30.10-59 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10... Headquarters for reading purposes or it may be purchased from the Society at 100 Barr Harbor Drive, West...

  20. Short-Term Hα Line Variations in Classical Be Stars: 59 Cyg and OT ...

    Indian Academy of Sciences (India)

    2009-07-23

    Jul 23, 2009 ... Abstract. We present the optical spectroscopic study of two classical Be stars, 59 Cyg and OT Gem obtained over a period of few months in 2009. We detected a rare triple-peak Hα emission phase in. 59 Cyg and a rapid decrease in the emission strength of Hα in OT Gem, which are used to understand.

  1. 47 CFR 59.4 - Definition of “qualifying carrier”.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Definition of âqualifying carrierâ. 59.4... (CONTINUED) INFRASTRUCTURE SHARING § 59.4 Definition of “qualifying carrier”. For purposes of this part, the term “qualifying carrier” means a telecommunications carrier that: (a) Lacks economies of scale or...

  2. 40 CFR 59.653 - How do I test portable fuel containers?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 5 2010-07-01 2010-07-01 false How do I test portable fuel containers... Families § 59.653 How do I test portable fuel containers? You must test the portable fuel container as... pressure cycles specified by this paragraph (a)(1), you may ask to use special test procedures under § 59...

  3. Gecko CD59 Is Implicated in Proximodistal Identity during Tail Regeneration

    Science.gov (United States)

    Jiang, Shengjuan; Zhou, Weijuan; Liu, Yan; Wang, Yingjie; Gu, Qing; Gu, Yun; Dong, Yingying; Liu, Mei; Gu, Xingxing; Ding, Fei; Gu, Xiaosong

    2011-01-01

    Several adult reptiles, such as Gekko japonicus, have the ability to precisely re-create a missing tail after amputation. To ascertain the associated acquisition of positional information from blastemal cells and the underlying molecular mechanism of tail regeneration, a candidate molecule CD59 was isolated from gecko. CD59 transcripts displayed a graded expression in the adult gecko spinal cord with the highest level in the anterior segment, with a stable expression along the normal tail. After tail amputation, CD59 transcripts in the spinal cord proximal to the injury sites increased markedly at 1 day and 2 weeks; whereas in the regenerating blastema, strong CD59 positive signals were detected in the blastemal cells anterior to the blastema, with a gradual decrease along the proximodistal (PD) axis. When treated with RA following amputation, CD59 transcripts in the blastema were up-regulated. PD confrontation assays revealed that the proximal blastema engulfed the distal one after in vitro culture, and rabbit-anti human CD59 antibody was able to block this PD engulfment. Overexpression of the CD59 during tail regeneration causes distal blastemal cells to translocate to a more proximal location. Our results suggest that position identity is not restricted to amphibian limb regeneration, but has already been established in tail blastema of reptiles. The CD59, a cell surface molecule, acted as a determinant of proximal–distal cell identity. PMID:21464923

  4. 40 CFR 59.629 - What decisions may EPA make regarding my certificate of conformity?

    Science.gov (United States)

    2010-07-01

    ... my certificate of conformity? 59.629 Section 59.629 Protection of Environment ENVIRONMENTAL... certificate of conformity? (a) If we determine your application is complete and shows that the emission family meets all the requirements of this subpart and the Act, we will issue a certificate of conformity for...

  5. Structural Analysis Of CD59 Of Chinese Tree Shrew: A New Reference Molecule For Human Immune System Specific CD59 Drug Discovery.

    Science.gov (United States)

    Panda, Subhamay; Kumari, Leena; Panda, Santamay

    2017-11-17

    Chinese tree shrews (Tupaia belangeri chinensis) bear several characteristics that are considered to be very crucial for utilizing in animal experimental models in biomedical research. Subsequent to the identification of key aspects and signaling pathways in nervous and immune systems, it is revealed that tree shrews acquires shared common as well as unique characteristics, and hence offers a genetic basis for employing this animal as a prospective model for biomedical research. CD59 glycoprotein, commonly referred to as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is encoded by the CD59 gene in human beings. It is the member of the LY6/uPAR/alpha-neurotoxin protein family. With this initial point the objective of this study was to determine a comparative composite based structure of CD59 of Chinese tree shrew. The additional objective of this study was to examine the distribution of negatively and positively charged amino acid over molecular modeled structure, distribution of secondary structural elements, hydrophobicity molecular surface analysis and electrostatic potential analysis with the assistance of several bioinformatical analytical tools. CD59 Amino acid sequence of Chinese tree shrew collected from the online database system of National Centre for Biotechnology Information. SignalP 4.0 online server was employed for detection of signal peptide instance within the protein sequence of CD59. Molecular model structure of CD59 protein was generated by the Iterative Threading ASSEmbly Refinement (I-TASSER) suite. The confirmation for three-dimensional structural model was evaluated by structure validation tools. Location of negatively and positively charged amino acid over molecular modeled structure, distribution of secondary structural elements, and hydrophobicity molecular surface analysis was performed with the help of Chimera tool. Electrostatic potential analysis was carried out with the adaptive Poisson

  6. Measurement of 59Ni and 63Ni by accelerator mass spectrometry at CIAE

    Science.gov (United States)

    Wang, Xiaoming; He, Ming; Ruan, Xiangdong; Xu, Yongning; Shen, Hongtao; Du, Liang; Xiao, Caijin; Dong, Kejun; Jiang, Shan; Yang, Xuran; Lan, Xiaoxi; Wu, Shaoyong; Zhao, Qingzhang; Cai, Li; Pang, Fangfang

    2015-10-01

    The long lived isotopes 59Ni and 63Ni can be used in many areas such as radioactive waste management, neutron dosimetry, cosmic radiation study, and so on. Based on the large accelerator and a big Q3D magnetic spectrometer, the measurement method for 59Ni and 63Ni is under development at the AMS facility at China Institute of Atomic Energy (CIAE). By using the ΔE-Q3D technique with the Q3D magnetic spectrometer, the isobaric interferences were greatly reduced in the measurements of 59Ni and 63Ni. A four anode gas ionization chamber was then used to further identify isobars. With these techniques, the abundance sensitivities of 59Ni and 63Ni measurements are determined as 59Ni/Ni = 1 × 10-13 and 63Ni/Ni = 2 × 10-12, respectively.

  7. CD59 Underlines the Antiatherosclerotic Effects of C-Phycocyanin on Mice

    Science.gov (United States)

    Chu, Xian-Ming; Xu, Ying-Jie; Yang, Fan; Lv, Cong-Yi; Nie, Shu-min

    2013-01-01

    The effects of C-phycocyanin (C-PC) on atherosclerosis and the regulatory effects of CD59 gene on anti-atherosclerotic roles of C-PC were investigated. Apolipoprotein E knockout (ApoE(−/−)) mice were randomly divided into four groups: control group, C-PC treatment group, CD59 transfection group and C-PC+CD59 synergy group. The mice were fed with high-fat-diet and treated with drug intervention at the same time. Results showed the atherosclerotic mouse model was successfully established. CD59 was over-expressed in blood and tissue cells. Single CD59 or C-PC could reduce blood lipid levels and promote the expression of anti-apoptotic Bcl-2 but inhibit pro-apoptotic Fas proteins in endothelial cells. The expression levels of cell cycle protein D1 (Cyclin D1) and mRNA levels of cyclin dependent protein kinase 4 (CDK4) in smooth muscle cells were restrained by CD59 and C-PC. CD59 or C-PC alone could inhibit the formation of atherosclerotic plaque by suppressing MMP-2 protein expression. In addition, C-PC could promote CD59 expression. So both CD59 and C-PC could inhibit the progress of atherosclerosis, and the anti-atherosclerotic effects of C-PC might be fulfilled by promoting CD59 expression, preventing smooth muscle cell proliferation and the apoptosis of endothelial cells, reducing blood fat levels, and at last inhibiting the development of atherosclerosis. PMID:24319687

  8. CD59 Underlines the Antiatherosclerotic Effects of C-Phycocyanin on Mice

    Directory of Open Access Journals (Sweden)

    Bing Li

    2013-01-01

    Full Text Available The effects of C-phycocyanin (C-PC on atherosclerosis and the regulatory effects of CD59 gene on anti-atherosclerotic roles of C-PC were investigated. Apolipoprotein E knockout (ApoE(−/− mice were randomly divided into four groups: control group, C-PC treatment group, CD59 transfection group and C-PC+CD59 synergy group. The mice were fed with high-fat-diet and treated with drug intervention at the same time. Results showed the atherosclerotic mouse model was successfully established. CD59 was over-expressed in blood and tissue cells. Single CD59 or C-PC could reduce blood lipid levels and promote the expression of anti-apoptotic Bcl-2 but inhibit pro-apoptotic Fas proteins in endothelial cells. The expression levels of cell cycle protein D1 (Cyclin D1 and mRNA levels of cyclin dependent protein kinase 4 (CDK4 in smooth muscle cells were restrained by CD59 and C-PC. CD59 or C-PC alone could inhibit the formation of atherosclerotic plaque by suppressing MMP-2 protein expression. In addition, C-PC could promote CD59 expression. So both CD59 and C-PC could inhibit the progress of atherosclerosis, and the anti-atherosclerotic effects of C-PC might be fulfilled by promoting CD59 expression, preventing smooth muscle cell proliferation and the apoptosis of endothelial cells, reducing blood fat levels, and at last inhibiting the development of atherosclerosis.

  9. Method 59

    DEFF Research Database (Denmark)

    Kjellsson, G.

    1994-01-01

    OCDE/GD(94)41. Er supplerende rapport til rapport: The OECD Workshop on Methods for Monitoring Organisms in the Environment, Ottawa 14-17 September 1992. Environment Monograph 90.......OCDE/GD(94)41. Er supplerende rapport til rapport: The OECD Workshop on Methods for Monitoring Organisms in the Environment, Ottawa 14-17 September 1992. Environment Monograph 90....

  10. Retinal Pre-Conditioning by CD59a Knockout Protects against Light-Induced Photoreceptor Degeneration.

    Directory of Open Access Journals (Sweden)

    Delu Song

    Full Text Available Complement dysregulation plays a key role in the pathogenesis of age-related macular degeneration (AMD, but the specific mechanisms are incompletely understood. Complement also potentiates retinal degeneration in the murine light damage model. To test the retinal function of CD59a, a complement inhibitor, CD59a knockout (KO mice were used for light damage (LD experiments. Retinal degeneration and function were compared in WT versus KO mice following light damage. Gene expression changes, endoplasmic reticulum (ER stress, and glial cell activation were also compared. At baseline, the ERG responses and rhodopsin levels were lower in CD59aKO compared to wild-type (WT mice. Following LD, the ERG responses were better preserved in CD59aKO compared to WT mice. Correspondingly, the number of photoreceptors was higher in CD59aKO retinas than WT controls after LD. Under normal light conditions, CD59aKO mice had higher levels than WT for GFAP immunostaining in Müller cells, mRNA and protein levels of two ER-stress markers, and neurotrophic factors. The reduction in photon capture, together with the neurotrophic factor upregulation, may explain the structural and functional protection against LD in the CD59aKO.

  11. CD59 deficiency is associated with chronic hemolysis and childhood relapsing immune-mediated polyneuropathy.

    Science.gov (United States)

    Nevo, Yoram; Ben-Zeev, Bruria; Tabib, Adi; Straussberg, Rachel; Anikster, Yair; Shorer, Zamir; Fattal-Valevski, Aviva; Ta-Shma, Asaf; Aharoni, Sharon; Rabie, Malcolm; Zenvirt, Shamir; Goldshmidt, Hanoch; Fellig, Yakov; Shaag, Avraham; Mevorach, Dror; Elpeleg, Orly

    2013-01-03

    CD59 deficiency is a common finding in RBCs and WBCs in patients with chronic hemolysis suffering from paroxysmal nocturnal hemoglobinuria in which the acquired mutation in the PIGA gene leads to membrane loss of glycosylphosphatidylinositol-anchored membrane proteins, including CD59. The objective of the present study was to elucidate the molecular basis of childhood familial chronic Coombs-negative hemolysis and relapsing polyneuropathy presenting as chronic inflammatory demyelinating polyradiculoneuropathy in infants of North-African Jewish origin from 4 unrelated families. A founder mutation was searched for using homozygosity mapping followed by exome sequencing. The expression of CD59, CD55, and CD14 was examined in blood cells by flow cytometry followed by Western blot of the CD59 protein. A homozygous missense mutation, p.Cys89Tyr in CD59, was identified in all patients. The mutation segregated with the disease in the families and had a carrier rate of 1:66 among Jewish subjects of North-African origin. The mutated protein was present in the patients' cells in reduced amounts and was undetectable on the membrane surface. Based on the results of the present study, we conclude that the Cys89Tyr mutation in CD59 is associated with a failure of proper localization of the CD59 protein in the cell surface. This mutation is manifested clinically in infancy by chronic hemolysis and relapsing peripheral demyelinating disease.

  12. The history of MF59(®) adjuvant: a phoenix that arose from the ashes.

    Science.gov (United States)

    O'Hagan, Derek T; Ott, Gary S; Nest, Gary Van; Rappuoli, Rino; Giudice, Giuseppe Del

    2013-01-01

    The first clinical trial of an MF59(®)-adjuvanted influenza vaccine (Novartis) was conducted 20 years ago in 1992. The product that emerged (Fluad(®), Novartis) was licensed first in Italy in 1997 and is now licensed worldwide in 30 countries. US licensure is expected in the coming years. By contrast, many alternative adjuvanted vaccines have failed to progress. The key decisions that allowed MF59 to succeed in such a challenging environment are highlighted here and the lessons that were learned along the way are discussed. MF59 was connected to vaccines that did not succeed and was perceived as a 'failure' before it was a success. Importantly, it never failed for safety reasons and was always well tolerated. Even when safety issues have emerged for alternative adjuvants, careful analysis of the substantial safety database for MF59 have shown that there are no significant concerns with widespread use, even in more 'sensitive' populations.

  13. calcinosis cutis – a series of 59 consecutive cases confined among ...

    African Journals Online (AJOL)

    2013-04-04

    Apr 4, 2013 ... Calcinosis is a condition consisting of massive subcutaneous deposits of ... Methodology: Data was collected from 59 patients who presented with clinical diagnosis ... Surgical treatment: under aseptic technique and local.

  14. Digest, IEEE/LEOS 1996 Summer Topical Meetings, August 5-9, 1996, Keystone, Colorado

    National Research Council Canada - National Science Library

    Labuda, Edward

    1997-01-01

    .... The conference was held 5-9 August 96 in Keystone, Colorado. The purpose of this symposium was to provide a professional forum for a broad exchange of information and ideals on advanced applications of lasers in materials processing...

  15. Improved detection limit for {sup 59}Ni using the technique of accelerator mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Persson, Per; Erlandsson, Bengt; Hellborg, Ragnar; Kiisk, Madis; Larsson, Ragnar; Skog, Goeran; Stenstroem, Kristina [Lund Univ. (Sweden). Dept. of Nuclear Physics

    2002-11-01

    59 Ni is produced by neutron activation in the stainless steel close to the core of a nuclear reactor. To be able to classify the different parts of the reactor with respect to their content of long-lived radionuclides before final storage it is important to measure the 59 Ni level. Accelerator mass spectrometry is an ultra-sensitive method for counting atoms, suitable for 59 Ni measurements. Improvements in the reduction of the background and in the chemical reduction of cobalt, the interfering isobar, have been made. This chemical purification is essential when using small tandem accelerators, <3 MV, combined with the detection of characteristic projectile X-rays. These improvements have lowered the detection limit for 59 Ni by a factor of twenty compared with the first value reported for the Lund AMS facility. Material from the Swedish nuclear industry has been analysed and examples of the results are presented.

  16. Predictors of Vaccination Card Retention in Children 12-59 months old in Karachi, Pakistan

    OpenAIRE

    Sheikh, Sana Sadiq; Ali, Syed Asad

    2014-01-01

    Objective: To determine the factors associated with retaining the vaccination card among care takers of 12-59 months old children in Karachi, Pakistan. Methods: This was an analytical cross-sectional study in Karachi. Households were randomly selected throughout a multistage cluster sampling technique. Data was collected for 504 children of 12- 59 months of age. Questionnaire was administered to caretakers to gather information regarding the children’s vaccination status, socio-demographi...

  17. Both Freshly Prepared and Frozen-Stored Amniotic Membrane Cells Express the Complement Inhibitor CD59

    Directory of Open Access Journals (Sweden)

    Ágnes Füst

    2012-01-01

    Full Text Available Amniotic membrane proved to be very effective tool in the treatment of a number of ocular surface diseases. The amniotic membrane, however, has to be stored before its transplantation onto the ocular surface followed by mandatory serologic control in order to exclude the transmission of certain viruses. Therefore it is most important to study if cryopreservation of the membrane affects cell surface expression of the molecules. We measured cell surface expression of CD59, a membrane-bound complement inhibitor on the cells of freshly prepared and cryopreserved amniotic membrane. Cells of amniotic membrane were separated mechanically. Epithelial and mesenchymal cells were identified by the intracellular expression of nanog and the cell surface ICAM1 positivity, respectively. Multicolor flow cytometric immunophenotyping was used for determination of the CD59 expression. CellQuest-Pro software program (Becton Dickinson was used both for measurements and analysis. CD59-positive cells could be detected in all investigated samples and in all investigated cell types, although the expression level of CD59 differed. CD59 was expressed both on freshly prepared and frozen-stored samples. Higher level of CD59 was detected on ICAM1+ mesenchymal cells than on nanog+ epithelial cells. Our findings indicate that amniotic membranes maintain their complement inhibiting capacity after cryopreservation.

  18. International need of discussion concerning the implementation of the guideline 2013/59/Euratom; Internationaler Diskussionsbedarf bei der Umsetzung der Richtlinie 2013/59/Euratom

    Energy Technology Data Exchange (ETDEWEB)

    Brendebach, Boris [Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) gGmbH, Koeln (Germany). Fachgebiet ' ' Stilllegung' '

    2017-10-01

    The implementation of the requirements of the guideline 2014/59/Euratom (radiation protection safety standards) is challenging for a number of EU member states. Several initiatives were introduced to support the member states accomplishing these challenges. In the frame of the initiatives indications were identified with respect to the need of harmonization for the embodiment of the regulations and the need of the recommendations for the implementation of the requirements. The contribution describes several initiatives and demonstrates exemplary the extracted insights.

  19. Biogas barometer. 5.9 MTOE recovered in 2008 in EU; Le barometre du biogaz. 5,9 MTEP valorisees en 2007 dans l'UE

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2008-07-15

    The major increase in the price of fossil fuels has made biogas more attractive. The application of biogas, which were once limited to recycling and/or recovering energy from waste, have widened with the use of energy crops. This has simulated European production, which has now reached 5,9 Mteps, i-e, a 20,5% increase in relation to 2006. (author)

  20. The (n, $\\gamma$) reaction in the s-process branching point $^{59}$Ni

    CERN Multimedia

    We propose to measure the $^{59}$Ni(n,$\\gamma$)$^{56}$Fe cross section at the neutron time of flight (n TOF) facility with a dedicated chemical vapor deposition (CVD) diamond detector. The (n, ) reaction in the radioactive $^{59}$Ni is of relevance in nuclear astrophysics as it can be seen as a rst branching point in the astrophysical s-process. Its relevance in nuclear technology is especially related to material embrittlement in stainless steel. There is a strong discrepancy between available experimental data and the evaluated nuclear data les for this isotope. The aim of the measurement is to clarify this disagreement. The clear energy separation of the reaction products of neutron induced reactions in $^{59}$Ni makes it a very suitable candidate for a rst cross section measurement with the CVD diamond detector, which should serve in the future for similar measurements at n_TOF.

  1. SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination

    DEFF Research Database (Denmark)

    Silva, Sonia; Altmannova, Veronika; Eckert-Boulet, Nadine

    2016-01-01

    for survival after genotoxic stress, it affects the outcome of recombination to promote conservative DNA repair. In some genetic assays, Rad52 and Rad59 SUMOylation act synergistically. Collectively, our data indicate that the described SUMO modifications affect the balance between conservative and non......Homologous recombination (HR) is essential for maintenance of genome stability through double-strand break (DSB) repair, but at the same time HR can lead to loss of heterozygosity and uncontrolled recombination can be genotoxic. The post-translational modification by SUMO (small ubiquitin......-like modifier) has been shown to modulate recombination, but the exact mechanism of this regulation remains unclear. Here we show that SUMOylation stabilizes the interaction between the recombination mediator Rad52 and its paralogue Rad59 in Saccharomyces cerevisiae. Although Rad59 SUMOylation is not required...

  2. Expression of the membrane complement regulatory proteins (CD55 and CD59 in human thymus.

    Directory of Open Access Journals (Sweden)

    Agnieszka Kinsner

    2007-01-01

    Full Text Available CD59 is one of the key molecules involved in cell protection against autologus complement. The fact that complement regulatory proteins are able to prevent hyperacute rejection of organs in pig to primate model, raises the question of possible complement regulatory protein (CRP involvement in the maturation of immunological system. We report here that in foetal and postnatal human thymus, CD59 and CD55 are primarily located on Hassall's corpuscles and medullary epithelial cells. This localization highly correlates with the expression of CD30L, which is the member of the tumour necrosis factor superfamily. Additionally, TUNEL technique was used to visualize distribution of apoptotic cells in the thymus, which revealed the presence of apoptotic cells closely associated with the Hassall's corpuscles. The observed co-localization of CD59, CD55 and CD30L might suggest an involvement of the complement system in thymic selection in humans.

  3. The (n, α) Reaction in the s-process Branching Point 59Ni

    CERN Document Server

    Weiß, C; Griesmayer, E.; Andrzejewski, J.; Badurek, G.; Chiaveri, E.; Dressler, R.; Ganesan, S.; Jericha, E.; Käppeler, F.; Koehler, P.; Lederer, C.; Leeb, H.; Marganiec, J.; Pavlik, A.; Perkowski, J.; Rauscher, T.; Reifarth, R.; Schumann, D.; Tagliente, G.; Vlachoudis, V.; Altstadt, S.; Audouin, L.; Barbagallo, M.; Bécares, V.; Bečvář, F.; Belloni, F.; Berthoumieux, E.; Billowes, J.; Boccone, V.; Bosnar, D.; Brugger, M.; Calviani, M.; Calviño, F.; Cano-Ott, D.; Carrapiço, C.; Cerutti, F.; Chin, M.; Colonna, N.; Cortés, G.; Cortés-Giraldo, M.A.; Diakaki, M.; Domingo-Pardo, C.; Duran, I.; Dzysiuk, N.; Eleftheriadis, C.; Ferrari, A.; Fraval, K.; García, A.R.; Giubrone, G.; Gómez-Hornillos, M.B.; Gonçalves, I.F.; González-Romero, E.; Gunsing, F.; Gurusamy, P.; Hernández-Prieto, A.; Jenkins, D.G.; Kadi, Y.; Karadimos, D.; Kivel, N.; Kokkoris, M.; Krtička, M.; Kroll, J.; Lampoudis, C.; Langer, C.; Leal-Cidoncha, E.; Leong, L.S.; Losito, R.; Mallick, A.; Manousos, A.; Martínez, T.; Massimi, C.; Mastinu, P.F.; Mastromarco, M.; Meaze, M.; Mendoza, E.; Mengoni, A.; Milazzo, P.M.; Mingrone, F.; Mirea, M.; Mondalaers, W.; Paradela, C.; Plompen, A.; Praena, J.; Quesada, J.M.; Riego, A.; Robles, M.S.; Roman, F.; Rubbia, C.; Sabaté-Gilarte, M.; Sarmento, R.; Saxena, A.; Schillebeeckx, P.; Schmidt, S.; Tain, J.L.; Tarrío, D.; Tassan-Got, L.; Tsinganis, A.; Valenta, S.; Vannini, G.; Variale, V.; Vaz, P.; Ventura, A.; Versaci, R.; Vermeulen, M.J.; Vlastou, R.; Wallner, A.; Ware, T.; Weigand, M.; Wright, T.; Žugec, P.

    The (n, α) reaction in the radioactive 59Ni is of relevance in nuclear astrophysics as 59Ni can be considered as the first branching point in the astrophysical s-process. Its relevance in nuclear technology is especially related to material embrittlement in stainless steel. However, there is a discrepancy between available experimental data and the evaluated nuclear data files for this reaction. At the n_TOF facility at CERN, a dedicated system based on sCVD diamond diodes was set up to measure the 59Ni(n, α)56Fe cross section. The results of this measurement, with special emphasis on the dominant resonance at 203 eV, are presented here.

  4. Safety and effectiveness of MF-59 adjuvanted influenza vaccines in children and adults.

    Science.gov (United States)

    Black, Steven

    2015-06-08

    The squalene oil-in-water emulsion MF-59 adjuvant was developed initially to enhance the immunogenicity of influenza vaccines in populations such as children and adults with known suboptimal response. Developed in the 1990s, it was initially licensed in Europe for use in seasonal influenza vaccine in the elderly. Since that time, both Avian and p2009H1N1 vaccines have also been developed. Overall, more than 30,000 individuals have participated in clinical trials of MF-59 adjuvanted vaccine and more than 160 million doses of licensed vaccine have been administered. Safety and effectiveness data from clinical trials and observation studies attest to the safety of MF-59 and to its ability to enhance the effectiveness of influenza vaccines in children and the elderly. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. The (n, α) Reaction in the s-process Branching Point 59Ni

    Science.gov (United States)

    Weiß, C.; Guerrero, C.; Griesmayer, E.; Andrzejewski, J.; Badurek, G.; Chiaveri, E.; Dressler, R.; Ganesan, S.; Jericha, E.; Käppeler, F.; Koehler, P.; Lederer, C.; Leeb, H.; Marganiec, J.; Pavlik, A.; Perkowski, J.; Rauscher, T.; Reifarth, R.; Schumann, D.; Tagliente, G.; Vlachoudis, V.; Altstadt, S.; Audouin, L.; Barbagallo, M.; Bécares, V.; Bečvář, F.; Belloni, F.; Berthoumieux, E.; Billowes, J.; Boccone, V.; Bosnar, D.; Brugger, M.; Calviani, M.; Calviño, F.; Cano-Ott, D.; Carrapiço, C.; Cerutti, F.; Chin, M.; Colonna, N.; Cortés, G.; Cortés-Giraldo, M. A.; Diakaki, M.; Domingo-Pardo, C.; Duran, I.; Dzysiuk, N.; Eleftheriadis, C.; Ferrari, A.; Fraval, K.; García, A. R.; Giubrone, G.; Gómez-Hornillos, M. B.; Gonçalves, I. F.; González-Romero, E.; Gunsing, F.; Gurusamy, P.; Hernández-Prieto, A.; Jenkins, D. G.; Kadi, Y.; Karadimos, D.; Kivel, N.; Kokkoris, M.; Krtička, M.; Kroll, J.; Lampoudis, C.; Langer, C.; Leal-Cidoncha, E.; Leong, L. S.; Losito, R.; Mallick, A.; Manousos, A.; Martínez, T.; Massimi, C.; Mastinu, P. F.; Mastromarco, M.; Meaze, M.; Mendoza, E.; Mengoni, A.; Milazzo, P. M.; Mingrone, F.; Mirea, M.; Mondalaers, W.; Paradela, C.; Plompen, A.; Praena, J.; Quesada, J. M.; Riego, A.; Robles, M. S.; Roman, F.; Rubbia, C.; Sabaté-Gilarte, M.; Sarmento, R.; Saxena, A.; Schillebeeckx, P.; Schmidt, S.; Tain, J. L.; Tarrío, D.; Tassan-Got, L.; Tsinganis, A.; Valenta, S.; Vannini, G.; Variale, V.; Vaz, P.; Ventura, A.; Versaci, R.; Vermeulen, M. J.; Vlastou, R.; Wallner, A.; Ware, T.; Weigand, M.; Wright, T.; Žugec, P.

    2014-06-01

    The (n, α) reaction in the radioactive 59Ni is of relevance in nuclear astrophysics as 59Ni can be considered as the first branching point in the astrophysical s-process. Its relevance in nuclear technology is especially related to material embrittlement in stainless steel. However, there is a discrepancy between available experimental data and the evaluated nuclear data files for this reaction. At the n_TOF facility at CERN, a dedicated system based on sCVD diamond diodes was set up to measure the 59Ni(n, α)56Fe cross section. The results of this measurement, with special emphasis on the dominant resonance at 203 eV, are presented here.

  6. Rotavirus vaccination coverage among children aged 2-59 months: a report from Guangzhou, China.

    Directory of Open Access Journals (Sweden)

    Qing He

    Full Text Available OBJECTIVE: We aimed to estimate the Lanzhou lamb rotavirus (LLR vaccination coverage (VC and timeliness among children aged 2 to 59 months in Guangzhou, China. METHODS: An electronic system-based VC survey was conducted using stratified cluster random sampling. RESULTS: We reported an overall Lanzhou lamb rotavirus vaccine coverage of 25.3% among children aged 2-59 months (2-8 months, 2.6% in Guangzhou, China. CONCLUSION: Great efforts should be taken to increase LLR VC in eligible children in Guangzhou, China.

  7. Thermal neutron capture γ-ray spectroscopy of59Ni and61Ni

    Science.gov (United States)

    Harder, A.; Michaelsen, S.; Lieb, K. P.; Williams, A. P.

    1993-06-01

    The γ-radiation emitted after thermal neutron capture in isotopically enriched58Ni and60Ni was measured at the ILL high flux reactor by means of Ge/NaI detectors operated in Compton suppression and pair spectrometer mode. The neutron binding energies were determined as B n (59Ni)=8999.15(23) keV and Bn(61Ni)=7820.07(20) keV; some 95% of the total γ-ray fluxes through59,61Ni were assigned. The γ-ray strength functions of the primary transitions and the level densities are discussed.

  8. Rad52 and Rad59 exhibit both overlapping and distinct functions

    DEFF Research Database (Denmark)

    Feng, Qi; Düring, Louis; Antúnez de Mayolo, Adriana

    2007-01-01

    Homologous recombination is an important pathway for the repair of DNA double-strand breaks (DSBs). In the yeast Saccharomyces cerevisiae, Rad52 is a central recombination protein, whereas its paralogue, Rad59, plays a more subtle role in homologous recombination. Both proteins can mediate...... annealing of complementary single-stranded DNA in vitro, but only Rad52 interacts with replication protein A and the Rad51 recombinase. We have studied the functional overlap between Rad52 and Rad59 in living cells using chimeras of the two proteins and site-directed mutagenesis. We find that Rad52 and Rad...

  9. Supplemental site inspection for Air Force Plant 59, Johnson City, New York, Volume 1: Investigation report

    Energy Technology Data Exchange (ETDEWEB)

    Nashold, B.; Rosenblatt, D.; Hau, J. [and others

    1995-08-01

    This summary describes a Supplemental Site Inspection (SSI) conducted by Argonne National Laboratory (ANL) at Air Force Plant 59 (AFP 59) in Johnson City, New York. All required data pertaining to this project were entered by ANL into the Air Force-wide Installation Restoration Program Information System (IRPIMS) computer format and submitted to an appropriate authority. The work was sponsored by the United States Air Force as part of its Installation Restoration Program (IRP). Previous studies had revealed the presence of contaminants at the site and identified several potential contaminant sources. Argonne`s study was conducted to answer questions raised by earlier investigations.

  10. 40 CFR 59.506 - How do I demonstrate compliance if I manufacture multi-component kits?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 5 2010-07-01 2010-07-01 false How do I demonstrate compliance if I manufacture multi-component kits? 59.506 Section 59.506 Protection of Environment ENVIRONMENTAL PROTECTION... § 59.506 How do I demonstrate compliance if I manufacture multi-component kits? (a) If you manufacture...

  11. 20 CFR 220.59 - Requesting examination by a specific physician, psychologist or institution-hearings officer...

    Science.gov (United States)

    2010-04-01

    ... physician, psychologist or institution-hearings officer hearing level. 220.59 Section 220.59 Employees... Consultative Examinations § 220.59 Requesting examination by a specific physician, psychologist or institution... examination by a particular physician, psychologist or institution. Some examples include the following: (a...

  12. Clinical outcomes among febrile children aged 2 to 59 months with ...

    African Journals Online (AJOL)

    Through a prospective cohort study designed to investigate clinical outcomes of children treated at the community level, we followed, for 7 days, children aged 2 to 59 months, who had negative mRDT results and were treated with antipyretic medication. Clinical outcomes were assessed on days 3 and 7 post-recruitment.

  13. 34 CFR 668.59 - Consequences of a change in application information.

    Science.gov (United States)

    2010-07-01

    ... Verification of Student Aid Application Information § 668.59 Consequences of a change in application... recalculates an applicant's EFC because of a change in application information resulting from the verification... applicant's EFC because of a change in application information resulting from the verification process and...

  14. Protein kinase inhibitors CK59 and CID755673 alter primary human NK cell effector functions

    Directory of Open Access Journals (Sweden)

    Maxi eScheiter

    2013-03-01

    Full Text Available Natural killer (NK cells are part of the innate immune response and play a crucial role in the defense against tumors and virus-infected cells. Their effector functions include the specific killing of target cells, as well as the modulation of other immune cells by cytokine release. Kinases constitute a relevant part in signaling, are prime targets in drug research and the protein kinase inhibitor Dasatinib is already used for immune-modulatory theraphies. In this study, we have tested the effects of the kinase inhibitors CK59 and CID755673. These inhibitors are directed against CaMKII (CK59 and PKD family kinases (CID755673 that were previously suggested as novel components of NK activation pathways. Here, we use a multi-parameter, FACS-based assay to validate the influence of CK59 and CID755673 on the effector functions of primary NK cells. Dose dependent treatment with CK59 and CID755673 indeed results in a significant reduction of NK cell degranulation markers and cytokine release in freshly isolated PBMC populations from healthy blood donors. These results underline the importance of CaMKII for NK cell signaling and suggest PKD2 as a novel signaling component in NK cell activation. Notably, kinase inhibition studies on pure NK cell populations indicate significant donor variations.

  15. Palmyra Atoll Site 15P 3/31/2004 59-60M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Palmyra Atoll, site 15P (05 52.219N, 162 02.697W), between 59 and 60 meters along a permanent transect.

  16. Translation of three mouse hepatitis virus strain A59 subgenomic RNAs in Xenopus laevis oocytes

    NARCIS (Netherlands)

    Horzinek, M.C.; Rottier, P.J.M.; Spaan, W.J.M.; Zeijst, B.A.M. van der

    1981-01-01

    We have purified the seven virus-specific RNAs which were previously shown to be induced in Sac(-) cells upon infection with mouse hepatitis virus strain A59 (W. J. M. Spaan, P. J. M. Rottier, M. C. Horzinek, and B. A. M. van der Zeijst, Virology 108:424-434, 1981). The individual RNAs, prepared by

  17. 29 CFR 1960.59 - Training of employees and employee representatives.

    Science.gov (United States)

    2010-07-01

    ... specialized job safety and health training appropriate to the work performed by the employee, for example... their rights and responsibilities. (b) Occupational safety and health training for employees of the... 29 Labor 9 2010-07-01 2010-07-01 false Training of employees and employee representatives. 1960.59...

  18. Nuclear Magnetic Moment of 59Cu with On-line $\\beta$-NMR on Oriented Nuclei

    CERN Document Server

    Golovko, V V; Phalet, T; Severijns, N; Delauré, B J; Beck, M; Kozlov, Yu V; Lindroth, A; Versyck, S; Zákoucký, D; Vénos, D; Srnka, D; Honusek, M; Herzog, P; Tramm, C; Köster, U; Towner, I S

    2004-01-01

    The nuclear magnetic moment of the nucleus 59Cu with one proton and two neutrons outside the closed N = Z = 28 shells, was measured in an on-line experiment combining beta-NMR with low temperature nuclear orientation and with particle detectors operating at a temperature of about 10K. From the data the center frequency \

  19. Nuclear magnetic moment of $^{59}$Cu with on-line $\\beta$-NMR on oriented nuclei

    CERN Document Server

    Golovko, V V; Phalet, T; Severijns, N; Delauré, B J; Beck, M; Kozlov, V; Lindroth, A; Versyck, S; Zákoucký, D; Srnka, D; Honusek, M; Herzog, P; Köster, U; Tramm, C; Towner, I S

    2004-01-01

    The nuclear magnetic moment of the nucleus $^{59}\\!$Cu, with one proton and two neutrons outside the closed N = Z = 28 shells, was measured in an on-line experiment combining $\\beta$-NMR with low temperature nuclear orientation and with particle detectors operating at a temperature of about 10 K. From the data the center frequency $\

  20. 7 CFR 59.202 - Mandatory daily reporting for barrows and gilts.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Mandatory daily reporting for barrows and gilts. 59... gilts. (a) Prior day report. The corporate officers or officially designated representatives of each packer that processes barrows and gilts shall report to the Secretary for each business day of the packer...

  1. 14 CFR 61.59 - Falsification, reproduction, or alteration of applications, certificates, logbooks, reports, or...

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Falsification, reproduction, or alteration...: PILOTS, FLIGHT INSTRUCTORS, AND GROUND INSTRUCTORS General § 61.59 Falsification, reproduction, or... authorization under this part; (3) Any reproduction for fraudulent purpose of any certificate, rating, or...

  2. 40 CFR 59.624 - How do I amend my application for certification?

    Science.gov (United States)

    2010-07-01

    ... PROGRAMS (CONTINUED) NATIONAL VOLATILE ORGANIC COMPOUND EMISSION STANDARDS FOR CONSUMER AND COMMERCIAL... Families § 59.624 How do I amend my application for certification? Before we issue you a certificate of... provisions of this section. After we have issued your certificate of conformity, you may send us an amended...

  3. 46 CFR 59.15-5 - Stayed furnaces and combustion chambers.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Stayed furnaces and combustion chambers. 59.15-5 Section... and combustion chambers. (a) Where the plate forming the walls of stayed furnaces or combustion... wall of a stayed furnace or combustion chamber, the defective portion of the plate shall be cut away...

  4. The clinical usefulness of NP-59 scintigraphy in adrenal cortical diseases

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Duk Kyu [College of Medicine, Donga Univ., Pusan (Korea, Republic of)

    1997-03-01

    {sup 131}I-6-{beta}-iodomethyl-19-norcholesterol (NP-59) has an advantage to assess adrenal dysfunction caused by adrenal cortical disorders. The aim of this study is to evaluate the clinical usefulness of NP-59 scintigraphy in each adrenal disease. Ten patients who did eleven NP-59 adrenal scintigraphies at Dong-A University Hospital from March 1990 to December 1996 were selected as the subject. Among the subject there were 5 cases of Cushing's syndrome, 2 cases of incidentaloma, 1 case of metastatic adrenal tumor, liver cirrhosis with hirsutism and hypertension respectively. Among 5 cases of Cushing's syndrome, there were 2 cases of Cushing's disease, 2 cases of adrenal adenoma and 1 case of adrenal carcinoma. There are no disagreement between clinical diagnosis and scan finding in Cushing's syndrome. In 2 incidentaloma cases, even though one is interpretated as a functioning tumor, both of 2 cases could avoid unnecessary biopsy according to scintigraphy result. One case of hirsutism, clinically adrenal originated, revealed the normal scintigraphic finding after dexamethasone suppression scan. It could suggest that the etiology of hirsutism was extra-adrenal origin. One case of hypertension took the study to exclude the possibility of primary aldosteronism. Normal suppression scan finding revealed that primary aldosteronism did not exist in this case. In conclusion, NP-59 scintigraphy was very useful in diagnosis and differential diagnosis of Cushing's syndrome and it could avoid unnecessary biopsy in the incidental adrenal tumor.

  5. Nutritional Status of Children Aged 6 to 59 Months in Community ...

    African Journals Online (AJOL)

    Community Based Education and Service (COBES) centres are annually used by Moi University College of Health Sciences for community diagnosis of various health problems including malnutrition. The objective was to determine the prevalence of malnutrition in children aged 5 to 59 months in selected COBES health ...

  6. 7 CFR 250.59 - Storage and inventory management of donated foods.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Storage and inventory management of donated foods. 250... National School Lunch Program (NSLP) and Other Child Nutrition Programs § 250.59 Storage and inventory management of donated foods. (a) General requirements. Distributing agencies, subdistributing agencies, and...

  7. Disentangling the roles of cholesterol and CD59 in intermedilysin pore formation.

    Science.gov (United States)

    Boyd, Courtney M; Parsons, Edward S; Smith, Richard A G; Seddon, John M; Ces, Oscar; Bubeck, Doryen

    2016-12-02

    The plasma membrane provides an essential barrier, shielding a cell from the pressures of its external environment. Pore-forming proteins, deployed by both hosts and pathogens alike, breach this barrier to lyse target cells. Intermedilysin is a cholesterol-dependent cytolysin that requires the human immune receptor CD59, in addition to cholesterol, to form giant β-barrel pores in host membranes. Here we integrate biochemical assays with electron microscopy and atomic force microscopy to distinguish the roles of these two receptors in mediating structural transitions of pore formation. CD59 is required for the specific coordination of intermedilysin (ILY) monomers and for triggering collapse of an oligomeric prepore. Movement of Domain 2 with respect to Domain 3 of ILY is essential for forming a late prepore intermediate that releases CD59, while the role of cholesterol may be limited to insertion of the transmembrane segments. Together these data define a structural timeline for ILY pore formation and suggest a mechanism that is relevant to understanding other pore-forming toxins that also require CD59.

  8. 77 FR 4758 - Foreign-Trade Zone 59-Lincoln, Nebraska, Application for Temporary/Interim Manufacturing...

    Science.gov (United States)

    2012-01-31

    ... Manufacturing Authority, Novartis Consumer Health, Inc. (Pharmaceutical Product Manufacturing), Lincoln, NE An... Lincoln Foreign-Trade Zone, Inc., grantee of FTZ 59, requesting temporary/interim manufacturing (T/ IM... request to the FTZ Board for FTZ manufacturing authority beyond a two-year period, which may include...

  9. Begonia semperflorens FB08-59 and FB08-163 clonal germplasm

    Science.gov (United States)

    FB08-59 is a dark-foliage, red-flowered wax begonia clone adapted to hot humid summers. It is the product of a recurrent selection breeding procedure to combine and improve the environmental tolerances identified in B. semperflorens ’Kaylen’ and B. cucullata arenosicola into a dark-foliaged, perenn...

  10. 28 CFR 0.59 - Certain certifications under 18 U.S.C. 3331 and 3503.

    Science.gov (United States)

    2010-07-01

    ... the Criminal Division pursuant to § 0.55, or is not within the cognizance of the Civil Rights Division... DEPARTMENT OF JUSTICE Criminal Division § 0.59 Certain certifications under 18 U.S.C. 3331 and 3503. (a) The Assistant Attorney General in charge of the Criminal Division is authorized to exercise or perform the...

  11. 46 CFR 52.01-105 - Piping, valves and fittings (modifies PG-58 and PG-59).

    Science.gov (United States)

    2010-10-01

    ... ENGINEERING POWER BOILERS General Requirements § 52.01-105 Piping, valves and fittings (modifies PG-58 and PG... jurisdiction of the ASME Boiler and Pressure Vessel Code must meet the appropriate requirements of part 56 of this subchapter. (b) In addition to the requirements in PG-58 and PG-59 of section I of the ASME Boiler...

  12. adherence to pneumonia guidelines for children 2 – 59 months at ...

    African Journals Online (AJOL)

    2014-01-01

    Jan 1, 2014 ... East African Medical Journal Vol. 91 No. 1 January 2014. ADHERENCE TO PNEUMONIA GUIDELINES FOR CHILDREN 2 – 59 MONTHS AT GARRISA PROVINCIAL. GENERAL HOSPITAL. C. M. Mutinda, MBChB, MMed, F. E. Onyango, MBChB, MMed, Professor, E. Maleche-Obimbo, MBChB, MMed,.

  13. 14 CFR 142.59 - Flight simulators and flight training devices.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight simulators and flight training... TRANSPORTATION (CONTINUED) SCHOOLS AND OTHER CERTIFICATED AGENCIES TRAINING CENTERS Personnel and Flight Training Equipment Requirements § 142.59 Flight simulators and flight training devices. (a) An applicant for, or...

  14. Identification of a novel fungus, Leptosphaerulina chartarum SJTU59 and characterization of its xylanolytic enzymes.

    Directory of Open Access Journals (Sweden)

    Qiong Wu

    Full Text Available Xylanolytic enzymes are widely used in processing industries, e.g., pulp and paper, food, livestock feeds, and textile. Furthermore, certain xylanotic enzymes have demonstrated the capability to improve the resistance and immunity of plants. Screening of high-yield microbial xylanolytic enzyme producers is significant for improving large-scale cost-effective xylanolytic enzyme production. This study provided new evidence of high-level xylanolytic enzyme production by a novel fungus, designated Leptosphaerulina chartarum SJTU59. Under laboratory conditions, L. chartarum SJTU59 produced xylanolytic enzymes of up to 17.566 U/mL (i.e., 878.307 U/g substrate. The enzyme solution was relatively stable over a wide range of pH (pH 3.0 to pH 9.0 and temperature (40°C to 65°C while showing high resistance to the majority of metal ions tested. Composition analysis of the hydrolytic products of xylan showed sufficient degradation by xylanolytic enzymes from L. chartarum SJTU59, mainly the monosaccharide xylose, and a small amount of xylobiose were enzymatically produced; whereas in the presence of sufficient xylan substrates, mainly xylooligosaccharides, an emerging prebiotic used in food industry, were produced. In addition, the xylanolytic enzyme preparation from L. chartarum SJTU59 could initiate tissue necrosis and oxidative burst in tobacco leaves, which may be related to enhanced plant defense to adversity and disease. L. chartarum SJTU59 possessed a complex xylanolytic enzyme system, from which two novel endo-β-1,4-xylanases of the glycoside hydrolase (GH family 10, one novel endo-β-1,4-xylanase of the GH family 11, and one novel β-xylosidase of the GH family 43 were obtained via rapid amplification of complementary DNA ends. Given the high yield and stable properties of xylanolytic enzymes produced by L. chartarum SJTU59, future studies will be conducted to characterize the properties of individual xylanolytic enzymes from L. chartarum SJTU59

  15. Gamma-ray mutagenesis studies in a new human-hamster hybrid, A(L)CD59(+/-), which has two human chromosomes 11 but is hemizygous for the CD59 gene

    Science.gov (United States)

    Kraemer, S. M.; Vannais, D. B.; Kronenberg, A.; Ueno, A.; Waldren, C. A.; Chatterjee, A. (Principal Investigator)

    2001-01-01

    Kraemer, S. M., Vannais, D. B., Kronenberg, A., Ueno, A. and Waldren, C. A. Gamma-Ray Mutagenesis Studies in a New Human-Hamster Hybrid, A(L)CD59(+/-), which has Two Human Chromosomes 11 but is Hemizygous for the CD59 Gene. Radiat. Res. 156, 10-19 (2001).We have developed a human-CHO hybrid cell line, named A(L)CD59(+/-), which has two copies of human chromosome 11 but is hemizygous for the CD59 gene and the CD59 cell surface antigen that it encodes. Our previous studies used the A(L) and A(L)C hybrids that respectively contain one or two sets of CHO chromosomes plus a single copy of human chromosome 11. The CD59 gene at 11p13.5 and the CD59 antigen encoded by it are the principal markers used in our mutagenesis studies. The hybrid A(L)CD59(+/-) contains two copies of human chromosome 11, only one of which carries the CD59 gene. The incidence of CD59 (-) mutants (formerly called S1(-)) induced by (137)Cs gamma rays is about fivefold greater in A(L)CD59(+/-) cells than in A(L) cells. Evidence is presented that this increase in mutant yield is due to the increased induction of certain classes of large chromosomal mutations that are lethal to A(L) cells but are tolerated in the A(L)CD59(+/-) hybrid. In addition, significantly more of the CD59 (-) mutants induced by (137)Cs gamma rays in A(L)CD59(+/-) cells display chromosomal instability than in A(L) cells. On the other hand, the yield of gamma-ray-induced CD59 (-) mutants in A(L)CD59(+/-) cells is half that of the A(L)C hybrid, which also tolerates very large mutations but has only one copy of human chromosome 11. We interpret the difference in mutability as evidence that repair processes involving the homologous chromosomes 11 play a role in determining mutant yields. The A(L)CD59(+/-) hybrid provides a useful new tool for quantifying mutagenesis and shedding light on mechanisms of genetic instability and mutagenesis.

  16. Communication: Electrical rectification of C{sub 59}N: The role of anchoring and doping sites

    Energy Technology Data Exchange (ETDEWEB)

    Tawfik, Sherif Abdulkader, E-mail: sherif.abbas@sydney.edu.au; Stampfl, C. [School of Physics, The University of Sydney, Sydney, New South Wales 2006 (Australia); Cui, X. Y.; Ringer, S. P. [Australian Centre for Microscopy and Microanalysis, and School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Sydney, New South Wales 2006 (Australia)

    2016-01-14

    Based on the nonequilibrium Green’s function formalism and density-functional theory, we investigate the onset of electrical rectification in a single C{sub 59}N molecule in conjunction with gold electrodes. Our calculations reveal that rectification is dependent upon the anchoring of the Au atom on C{sub 59}N; when the Au electrode is singly bonded to a C atom (labeled here as A), the system does not exhibit rectification, whereas when the electrode is connected to the C–C bridge site between two hexagonal rings (labeled here as B), transmission asymmetry is observed, where the rectification ratio reaches up to 2.62 at ±1 V depending on the N doping site relative to the anchoring site. Our analysis of the transmission mechanism shows that N doping of the B configuration causes rectification because more transmission channels are available for transmission in the B configuration than in the A configuration.

  17. The influence of cheerleading exercises on the schoolchildren's physical health of 5-9th forms

    Directory of Open Access Journals (Sweden)

    Bala T.M.

    2012-04-01

    Full Text Available Physical health indexes of schoolchildren in 5-9th forms comprehensive secondary school are given in this article, and also their changes under the influence of specially matched cheerleading exercises. Schoolchildren's physical health level was determined by Robinson index, Skibinskiy index, Shapovalova index, Ketle index 2, Ruphie index. 255 schoolchildren aged 10-15 years took part in investigation, from which it was made five experimental groups and five control groups. Information of primary researches testify about the middle level of physical health of the children investigation contingent. It is set that inclusion cheerleading exercises in the process of experimental groups schoolchildren physical education, positively influenced on a level them physical health, which became above average level. Efficiency of cheerleading exercises influence is experimentally well-proven on schoolchildren Physical health in 5-9th forms.

  18. Viral protein synthesis in mouse hepatitis virus strain A59 infected cells; effect of tunicamycin

    NARCIS (Netherlands)

    Horzinek, M.C.; Rottier, P.J.M.; Zeijst, B.A.M. van der

    1981-01-01

    We identified eight protein species in virions of mouse hepatitis virus strain A59. Based on their sizes, prosthetic groups, and locations in virions, these proteins were designated gp180/E2, gp90/E2, pp54/N, gp26.5/E1, gp25.5/E1, p24/E1, p22/X, and p14.5/Y. The positions of the last two proteins in

  19. Cummins Engine Company B5.9 Propane Engine Development, Certification, and Demonstration Project

    Energy Technology Data Exchange (ETDEWEB)

    The ADEPT Group, Inc. (Los Angeles, California)

    1998-12-18

    The objective of this project was to successfuly develop and certify an LPG-dedicated medium-duty original equipment manufacturer (OEM) engine that could be put into production. The engine was launched into production in 1994, and more than 800 B5.9G engines are now in service in the United States and abroad. This engine is now offered by more than 30 bus and truck OEMs.

  20. Prevalence of anemia in children 6-59 months old in the state of Pernambuco, Brazil

    Directory of Open Access Journals (Sweden)

    Mônica M. Osório

    2001-08-01

    Full Text Available Objective. To determine the prevalence of anemia in children 6-59 months old in Pernambuco, a state in northeastern Brazil, so as to help guide health and nutrition policies there. Methods. In 1997 a representative sample of 777 young children had their hemoglobin concentration measured. The sampling process was in three stages. First, 18 municipalities were randomly selected to represent the state and its three geographic areas (metropolitan region of Recife, urban interior, and rural interior. Next, using census lists, 45 census sectors were randomly chosen. Finally, 777 children aged 6-59 months old were selected. Blood was collected by venipuncture, and hemoglobin was measured with a portable hemoglobinometer. In the analysis, prevalence was weighted to reflect the census age distribution. Results. The prevalence of anemia among children 6-59 months old was 40.9% for the state as a whole. Prevalence in the metropolitan region of Recife was 39.6%, and it was 35.9% in the urban interior. The rural interior had the highest prevalence, 51.4%. Prevalence was twice as high in children aged 6-23 months as among those 24-59 months old, 61.8% vs. 31.0% (chi² = 77.9, P < 0.001. The mean hemoglobin concentrations in the younger and older age groups were 10.4 g/dL (standard deviation (SD = 1.5 and 11.4 g/dL (SD = 1.4, respectively. There was no statistically significant difference between the sexes in terms of prevalence. Conclusions. This is the first statewide assessment of anemia prevalence among young children in Brazil. Given the very high prevalence of anemia among the children studied in Pernambuco, especially those in the age group of 6-23 months, public health interventions are needed.

  1. THE MERGER HISTORY, ACTIVE GALACTIC NUCLEUS, AND DWARF GALAXIES OF HICKSON COMPACT GROUP 59

    Energy Technology Data Exchange (ETDEWEB)

    Konstantopoulos, I. S.; Charlton, J. C.; Brandt, W. N.; Eracleous, M.; Gronwall, C. [Department of Astronomy and Astrophysics, The Pennsylvania State University, University Park, PA 16802 (United States); Gallagher, S. C.; Fedotov, K.; Hill, A. R. [Department of Physics and Astronomy, The University of Western Ontario, London, ON N6A 3K7 (Canada); Durrell, P. R. [Department of Physics and Astronomy, Youngstown State University, Youngstown, OH 44555 (United States); Tzanavaris, P.; Hornschemeier, A. E. [Laboratory for X-ray Astrophysics, NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Zabludoff, A. I. [Steward Observatory, University of Arizona, Tucson, AZ 85721 (United States); Maier, M. L. [Gemini Observatory, Casilla 603, Colina el Pino S/N, La Serena (Chile); Elmegreen, D. M. [Department of Physics and Astronomy, Vassar College, Poughkeepsie, NY 12604 (United States); Johnson, K. E.; Walker, L. M. [Department of Astronomy, University of Virginia, P. O. Box 400325, Charlottesville, VA 22904 (United States); Maybhate, A. [Space Telescope Science Institute, Baltimore, MD (United States); English, J. [University of Manitoba, Winnipeg, MN (Canada); Mulchaey, J. S., E-mail: iraklis@astro.psu.edu [Carnegie Observatories, Pasadena, CA 91101 (United States)

    2012-01-20

    Compact group galaxies often appear unaffected by their unusually dense environment. Closer examination can, however, reveal the subtle, cumulative effects of multiple galaxy interactions. Hickson Compact Group (HCG) 59 is an excellent example of this situation. We present a photometric study of this group in the optical (Hubble Space Telescope), infrared (Spitzer), and X-ray (Chandra) regimes aimed at characterizing the star formation and nuclear activity in its constituent galaxies and intra-group medium. We associate five dwarf galaxies with the group and update the velocity dispersion, leading to an increase in the dynamical mass of the group of up to a factor of 10 (to 2.8 Multiplication-Sign 10{sup 13} M{sub Sun }), and a subsequent revision of its evolutionary stage. Star formation is proceeding at a level consistent with the morphological types of the four main galaxies, of which two are star-forming and the other are two quiescent. Unlike in some other compact groups, star-forming complexes across HCG 59 closely follow mass-radius scaling relations typical of nearby galaxies. In contrast, the ancient globular cluster populations in galaxies HCG 59A and B show intriguing irregularities, and two extragalactic H II regions are found just west of B. We age-date a faint stellar stream in the intra-group medium at {approx}1 Gyr to examine recent interactions. We detect a likely low-luminosity active galactic nucleus in HCG 59A by its {approx}10{sup 40} erg s{sup -1} X-ray emission; the active nucleus rather than star formation can account for the UV+IR spectral energy distribution. We discuss the implications of our findings in the context of galaxy evolution in dense environments.

  2. Risk Factors of Underweight in Children Aged 6–59 Months in Ethiopia

    OpenAIRE

    Tosheno, Deneke; Mehretie Adinew, Yohannes; Thangavel, Thilagavathi; Bitew Workie, Shimelash

    2017-01-01

    Background Undernutrition in early childhood has irreversible and long-lasting implications. Hence, this study was aimed at assessing risk factors of child undernutrition. Methods A community-based cross-sectional study was conducted on 642 households with mothers to children pairs aged 6–59 months selected by a multistage systematic random sampling method. Child anthropometric measurements on weight were recorded using standardized and calibrated weighing scales. Weight-for-age was compared ...

  3. The Merger History, AGN and Dwarf Galaxies of Hickson Compact Group 59

    Science.gov (United States)

    Konstantopoulos, I. S.; Gallagher, S. C.; Fedotov, K.; Durrell, P. R.; Tzanavaris, P.; Hill, A. R.; Zabludoff, A. I.; Maier, M. L.; Elmegreen, D. M.; Charlton, J. C.; hide

    2011-01-01

    Compact group galaxies often appear unaffected by their unusually dense environment. Closer examination can, however, reveal the subtle, cumulative effects of multiple galaxy interactions. Hickson Compact Group (HCG) 59 is an excellent example of this situation. We present a photometric study of this group in the optical (HST), infrared (Spitzer) and X-ray (Chandra) regimes aimed at characterizing the star formation and nuclear activity in its constituent galaxies and intra-group medium. We associate five dwarf galaxies with the group and update the velocity dispersion, leading to an increase in the dynamical mass of the group of up to a factor of 10 (to 2.8 x 10(exp 13) Stellar Mass), and a subsequent revision of its evolutionary stage. Star formation is proceeding at a level consistent with the morphological types of the four main galaxies, of which two are star-forming and the other two quiescent. Unlike in some other compact groups, star-forming complexes across HCG 59 closely follow mass-radius scaling relations typical of nearby galaxies. In contrast, the ancient globular cluster populations in galaxies HCG 59A and B show intriguing irregularities, and two extragalactic HII regions are found just west of B. We age-date a faint stellar stream in the intra-group medium at approx. 1 Gyr to examine recent interactions. We detect a likely low-luminosity AGN in HCG 59A by its approx. 10(exp 40) erg/s X-ray emission; the active nucleus rather than star formation can account for the UV+IR SED. We discuss the implications of our findings in the context of galaxy evolution in dense environments.

  4. Risk Factors of Underweight in Children Aged 6–59 Months in Ethiopia

    OpenAIRE

    Tosheno, Deneke; Mehretie Adinew, Yohannes; Thangavel, Thilagavathi; Bitew Workie, Shimelash

    2017-01-01

    Background. Undernutrition in early childhood has irreversible and long-lasting implications. Hence, this study was aimed at assessing risk factors of child undernutrition. Methods. A community-based cross-sectional study was conducted on 642 households with mothers to children pairs aged 6–59 months selected by a multistage systematic random sampling method. Child anthropometric measurements on weight were recorded using standardized and calibrated weighing scales. Weight-for-age was compare...

  5. Social Costs of Iron Deficiency Anemia in 6-59-Month-Old Children in India.

    Science.gov (United States)

    Plessow, Rafael; Arora, Narendra Kumar; Brunner, Beatrice; Tzogiou, Christina; Eichler, Klaus; Brügger, Urs; Wieser, Simon

    2015-01-01

    Inadequate nutrition has a severe impact on health in India. According to the WHO, iron deficiency is the single most important nutritional risk factor in India, accounting for more than 3% of all disability-adjusted life years (DALYs) lost. We estimate the social costs of iron deficiency anemia (IDA) in 6-59-month-old children in India in terms of intangible costs and production losses. We build a health economic model estimating the life-time costs of a birth cohort suffering from IDA between the ages of 6 and 59 months. The model is stratified by 2 age groups (6-23 and 24-59-months), 2 geographical areas (urban and rural), 10 socio-economic strata and 3 degrees of severity of IDA (mild, moderate and severe). Prevalence of anemia is calculated with the last available National Family Health Survey. Information on the health consequences of IDA is extracted from the literature. IDA prevalence is 49.5% in 6-23-month-old and 39.9% in 24-58-month-old children. Children living in poor households in rural areas are particularly affected but prevalence is high even in wealthy urban households. The estimated yearly costs of IDA in 6-59-month-old children amount to intangible costs of 8.3 m DALYs and production losses of 24,001 m USD, equal to 1.3% of gross domestic product. Previous calculations have considerably underestimated the intangible costs of IDA as the improved WHO methodology leads to a threefold increase of DALYs due to IDA. Despite years of iron supplementation programs and substantial economic growth, IDA remains a crucial public health issue in India and an obstacle to the economic advancement of the poor. Young children are especially vulnerable due to the irreversible effects of IDA on cognitive development. Our research may contribute to the design of new effective interventions aiming to reduce IDA in early childhood.

  6. 59th Medical Wing Office of the Chief Scientists Research Highlights Flyer-April 2016

    Science.gov (United States)

    2016-05-09

    Ambulatory Surgical Center (WHASC) internship and residency programs. 3. Please know that if you are a Graduate Health Sciences Education student and your...Blointegratable NPwt (Negative Pressure Wound Therapy) Sponge in a Large Animal Model of Composite Tissue Loss" (Pl: Lt Col Michael Davis, USAISR...Deputy Commander (59 MOW)) was accepted for a podium presentation at the 2016 International Surgical Congress of the Association of Surgeons of Great

  7. Prevalence and Risk Factors of Anemia among Children 6?59 Months Old in Haiti

    OpenAIRE

    Mohamed Ag Ayoya; Ismael Ngnie-Teta; Marie Nancy Séraphin; Aissa Mamadoultaibou; Ellen Boldon; Jean Ernst Saint-Fleur; Leslie Koo; Samuel Bernard

    2013-01-01

    Anemia has serious consequences on child growth, development, and survival. This study was conducted in Fond des Blancs and Villa, Haiti, to assess the prevalence of childhood anemia and its risk factors in order to inform program design. Children 6?59 months old (n = 557) were selected using a cross-sectional multistage sampling methodology. Hemoglobin was measured using the HemoCue technique. Descriptive and multivariate analyses were performed to determine prevalence and factors associated...

  8. Predictors of Vaccination Card Retention in Children 12-59 months old in Karachi, Pakistan

    Directory of Open Access Journals (Sweden)

    Sana Sadiq Sheikh

    2014-05-01

    Full Text Available Objective: To determine the factors associated with retaining the vaccination card among care takers of 12-59 months old children in Karachi, Pakistan. Methods: This was an analytical cross-sectional study in Karachi. Households were randomly selected throughout a multistage cluster sampling technique. Data was collected for 504 children of 12- 59 months of age. Questionnaire was administered to caretakers to gather information regarding the children’s vaccination status, socio-demographic characteristics and reviewing their vaccination cards. Statistical analysis was done by SPSS 19 using logistic regression. Results: Among 462 vaccinated children, caretakers of 33% provided vaccination cards. Odds of card retention decrease if the caretaker has a large household i.e., >5 people sharing one room (AOR 0.277, 95% CI: 0.096, 0.797 and if the child is of four to five years of age (AOR 0.544, 95% CI: 0.305, 0.970. Gender of the child, and the caretaker’s education and access to electronic media were not significant predictors of vaccination card retention in our study. Conclusion: Our study showed that vaccination card retention for children 12-59 months of age was low (33% in Karachi. There is a need to educate caretakers of young children regarding the importance of keeping vaccination card and to disseminate this information through healthcare providers. Improving vaccination card retention is one of the key measures which will help towards accurately estimating coverage and to inform health policy decisions.

  9. Predictors of Vaccination Card Retention in Children 12-59 months old in Karachi, Pakistan.

    Science.gov (United States)

    Sheikh, Sana Sadiq; Ali, Syed Asad

    2014-05-01

    To determine the factors associated with retaining the vaccination card among care takers of 12-59 months old children in Karachi, Pakistan. This was an analytical cross-sectional study in Karachi. Households were randomly selected throughout a multistage cluster sampling technique. Data was collected for 504 children of 12- 59 months of age. Questionnaire was administered to caretakers to gather information regarding the children's vaccination status, socio-demographic characteristics and reviewing their vaccination cards. Statistical analysis was done by SPSS 19 using logistic regression. Among 462 vaccinated children, caretakers of 33% provided vaccination cards. Odds of card retention decrease if the caretaker has a large household i.e., >5 people sharing one room (AOR 0.277, 95% CI: 0.096, 0.797) and if the child is of four to five years of age (AOR 0.544, 95% CI: 0.305, 0.970). Gender of the child, and the caretaker's education and access to electronic media were not significant predictors of vaccination card retention in our study. Our study showed that vaccination card retention for children 12-59 months of age was low (33%) in Karachi. There is a need to educate caretakers of young children regarding the importance of keeping vaccination card and to disseminate this information through healthcare providers. Improving vaccination card retention is one of the key measures which will help towards accurately estimating coverage and to inform health policy decisions.

  10. Mumps Seroprevalence in not Vaccinated Children Aged Between 0-59 Months in Adana

    Directory of Open Access Journals (Sweden)

    Akgun Yaman

    2010-02-01

    Full Text Available AIM: This study aims to find out the mumps seroprevalence in 0-59 month old children who were not vaccinated for mumps in the duty area of Dogankent Health Center where people of low socio-economic level lives. METHOD: A cross-sectional study was made on 331 children aged between 0-59 months who were not vaccinated with rubella vaccine. RESULTS: Mumps seropositivity was found as 35.3%. Mumps seropositivity was significantly high in 24-35 month old boys, and fathers who haven’t incame/occupation (p0.05. CONCLUSION: In the present study, mumps seropositivity is low in children aged 0- 59 months. In order to eradicate mumps, it is necessary that use of MMR vaccine should be expanded nationwide rapidly by the Ministry of Health; the regulation should be revised to include the children born before 2005. [TAF Prev Med Bull 2010; 9(1.000: 29-36

  11. Consumo alimentar entre crianças brasileiras com idade de 6 a 59 meses Food consumption Brazilian children by 6 to 59 months of age

    Directory of Open Access Journals (Sweden)

    Gisele Ane Bortolini

    2012-09-01

    Full Text Available O objetivo foi avaliar o consumo alimentar em crianças brasileiras de 6-59 meses de idade, por região e zona de residência. Trata-se de estudo descritivo transversal com 4.322 crianças investigadas na Pesquisa Nacional de Demografia e Saúde (2006/2007. Observou-se baixo consumo diário de verduras (12,7%, legumes (21,8%, carnes (24,6% e elevado consumo de refrigerantes (40,5%, alimentos fritos (39,4%, salgadinhos (39,4%, doces (37,8%, na frequência de uma a três vezes na semana. Comparando-se as regiões, as crianças residentes no Sul, Sudeste e Centro-oeste consumiram com mais frequência arroz, pão, batata, feijão, verdura de folha, legumes e carne, mas também consumiram, mais frequentemente, alimentos não recomendados para a idade, como doces e refrigerantes. Crianças da zona rural apresentaram menor consumo dos alimentos recomendados para a idade e, também, dos não recomendados, quando comparadas às crianças da zona urbana. O consumo alimentar evidenciado neste estudo não está de acordo com recomendações de alimentação saudável para crianças.The aim of this study was to assess food consumption in Brazilian children 6 to 59 months of age by region of the country and area of residence. This was a descriptive cross-sectional study of 4,322 children in the National Demographic and Health Survey (2006-2007. The data showed low daily consumption of leafy vegetables (12.7%, vegetables (21.8%, and meat (24.6% and high consumption (1-3 times a week of soft drinks (40.5%, fried foods (39.4%, salty snacks (39.4%, and sweets (37.8%. Comparing the regions of Brazil, children in the South, Southeast, and Central-West consumed more rice, bread, potatoes, beans, greens, vegetables, and meat, but they also ate more foods not recommended for their age, like sweets and soft drinks (soda. Rural children showed lower consumption of foods recommended for their age and also those not recommended for their age, as compared to their urban

  12. Differentiation of Clonal Complex 59 Community-Associated Methicillin-Resistant Staphylococcus aureus in Western Australia▿ ‡

    OpenAIRE

    Coombs, Geoffrey W.; Monecke, Stefan; Ehricht, Ralf; Slickers, Peter; Pearson, Julie C.; Tan, Hui-leen; Christiansen, Keryn J.; O'Brien, Frances G.

    2010-01-01

    Clonal complex 59 (CC59) community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains were characterized using pulsed-field gel electrophoresis, spa typing, multilocus sequence typing, diagnostic DNA microarrays, and PCRs targeting staphylococcal cassette chromosome mec (SCCmec) elements and Panton-Valentine leukocidin (PVL). Six distinct groups within CC59 were characterized. At least seven different variants of SCCmec elements were identified (IVa [2B], IVb [2B], IVd [...

  13. Characterization of the in vivo sites of serine phosphorylation on Lck identifying serine 59 as a site of mitotic phosphorylation.

    Science.gov (United States)

    Kesavan, Kamala P; Isaacson, Christina C; Ashendel, Curtis L; Geahlen, Robert L; Harrison, Marietta L

    2002-04-26

    The lymphocyte-specific protein-tyrosine kinase Lck plays a critical role in T cell activation. In response to T cell antigen receptor binding Lck undergoes phosphorylation on serine residues that include serines 59 and 194. Serine 59 is phosphorylated by ERK mitogen-activated protein kinase. Recently, we showed that in mitotic T cells Lck becomes hyper-phosphorylated on serine residues. In this report, using one-dimensional phosphopeptide mapping analysis, we identify serine 59 as a site of in vivo mitotic phosphorylation in Lck. The mitotic phosphorylation of serine 59 did not require either the catalytic activity or functional SH2 or SH3 domains of Lck. In addition, the presence of ZAP-70 also was dispensable for the phosphorylation of serine 59. Although previous studies demonstrated that serine 59 is a substrate for the ERK MAPK pathway, inhibitors of this pathway did not block the mitotic phosphorylation of serine 59. These results identify serine 59 as a site of mitotic phosphorylation in Lck and suggest that a pathway distinct from that induced by antigen receptor signaling is responsible for its phosphorylation. Thus, the phosphorylation of serine 59 is the result of two distinct signaling pathways, differentially activated in response to the physiological state of the T cell.

  14. Molecular and functional characterization of CD59 from Nile tilapia (Oreochromis niloticus) involved in the immune response to Streptococcus agalactiae.

    Science.gov (United States)

    Gan, Zhen; Wang, Bei; Zhou, Wei; Lu, Yishan; Zhu, Weiwei; Tang, Jufen; Jian, JiChang; Wu, Zaohe

    2015-05-01

    CD59, the major inhibitor of membrane attack complex, plays a crucial role in regulation of complement activation. In this paper, a CD59 gene of Nile tilapia, Oreochromis niloticus (designated as On-CD59) was cloned and its expression pattern under the stimulation of Streptococcus agalactiae was investigated. Sequence analysis showed main structural features required for complement-inhibitory activity were detected in the deduced amino acid sequence of On-CD59. In healthy Nile tilapia, the On-CD59 transcripts could be detected in all the examined tissues, with the most abundant expression in the brain. When immunized with inactivated S. agalactiae, there was a clear time-dependent expression pattern of On-CD59 in the skin, brain, head kidney, thymus and spleen, with quite different kinetic expressions. The assays for the complement-inhibitory activity suggested that recombinant On-CD59 protein had a species-selective inhibition of complement. Moreover, our works showed that recombinant On-CD59 protein may possess both binding activities to PGN and LTA and inhibiting activity of S. agalactiae. These findings indicated that On-CD59 may play important roles in the immune response to S. agalactiae in Nile tilapia. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Editorial Revista Contaduría y Administración Vol. 59 N.1

    OpenAIRE

    Cardiel-Hurtado Jorge

    2014-01-01

    Estimados lectores: presentamos a ustedes el primer número del volumen 59, correspondiente al primer trimestre del año 2014, en el que encontrarán diez artículos que versan sobre cuestiones de gran trascendencia académica y profesional en las áreas de recursos humanos, finanzas y banca, así como de mercadotecnia y tecnología, provenientes de cuatro universidades extranjeras y siete nacionales. Aprovechamos este inicio de año y de volumen para agradecer a quienes hacen posible esta revista Con...

  16. Stable and high-yielding intrinsic 59Fe-radiolabeling of the intravenous iron preparations Monofer and Cosmofer

    DEFF Research Database (Denmark)

    Jensen, Andreas Tue Ingemann; Severin, Gregory; Andreasen, Hans B.

    2016-01-01

    Commercial iron supplements Monofer((R)) and Cosmofer((R)) were intrinsically radiolabeled with Fe-59 for the purpose of tracing iron absorption in vivo. Optimized procedures aimed at introducing Fe-59 into the macromolecular construct in a form that was as chemically equivalent to the matrix iro...

  17. Specific acquisition of functional CD59 but not CD46 or CD55 by hepatitis C virus.

    Directory of Open Access Journals (Sweden)

    Asim Ejaz

    Full Text Available Viruses of different families encode for regulators of the complement system (RCAs or acquire such RCAs from the host to get protection against complement-mediated lysis (CML. As hepatitis C virus (HCV shares no genetic similarity to any known RCA and is detectable at high titers in sera of infected individuals, we investigated whether HCV has adapted host-derived RCAs to resist CML. Here we report that HCV selectively incorporates CD59 while neither CD55, nor CD46 are associated with the virus. The presence of CD59 was shown by capture assays using patient- and cell culture-derived HCV isolates. Association of CD59 with HCV was further confirmed by Western blot analysis using purified viral supernatants from infected Huh 7.5 cells. HCV captured by antibodies specific for CD59 remained infectious for Huh 7.5 cells. In addition, blocking of CD59 in the presence of active complement reduced the titer of HCV most likely due to CML. HCV produced in CD59 knock-down cells were more significantly susceptible to CML compared to wild type virus, but neither replication, assembly nor infectivity of the virus seemed to be impaired in the absence of CD59. In summary our data indicate that HCV incorporates selectively CD59 in its envelope to gain resistance to CML in serum of infected individuals.

  18. 40 CFR 59.622 - What are the general requirements for obtaining a certificate of conformity and producing...

    Science.gov (United States)

    2010-07-01

    ... obtaining a certificate of conformity and producing portable fuel containers under it? 59.622 Section 59.622... VOLATILE ORGANIC COMPOUND EMISSION STANDARDS FOR CONSUMER AND COMMERCIAL PRODUCTS Control of Evaporative... general requirements for obtaining a certificate of conformity and producing portable fuel containers...

  19. 40 CFR 59.626 - What emission testing must I perform for my application for a certificate of conformity?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 5 2010-07-01 2010-07-01 false What emission testing must I perform for my application for a certificate of conformity? 59.626 Section 59.626 Protection of Environment... application for a certificate of conformity? This section describes the emission testing you must perform to...

  20. The $^{59}$Cu(p,$\\alpha$) cross section and its implications for nucleosynthesis in core collapse supernovae

    CERN Multimedia

    The $^{59}$Cu(p,$\\alpha$) reaction is key for heavy element synthesis in the vp-process, since it may hinder the reaction flow to higher masses by recycling material back to $^{56}$Ni and it has a strong influence on the production of the cosmic X-ray sources $^{55}$Fe and $^{59}$Ni. The intense and highly energetic $^{59}$Cu beams provided by the new HIE-ISOLDE facility will for the first time allow a direct measurement of this reaction at astrophysical energies, making it one of only few cases where a direct study is possible with a radioactive beam. We propose to measure the $^{59}$Cu(p,$\\alpha$) reaction for the first time using $^{59}$Cu beams from the HIE-ISOLDE facility.

  1. Lck mediates signal transmission from CD59 to the TCR/CD3 pathway in Jurkat T cells.

    Science.gov (United States)

    Lipp, Anna M; Juhasz, Kata; Paar, Christian; Ogris, Christoph; Eckerstorfer, Paul; Thuenauer, Roland; Hesse, Jan; Nimmervoll, Benedikt; Stockinger, Hannes; Schütz, Gerhard J; Bodenhofer, Ulrich; Balogi, Zsolt; Sonnleitner, Alois

    2014-01-01

    The glycosylphosphatidylinositol (GPI)-anchored molecule CD59 has been implicated in the modulation of T cell responses, but the underlying molecular mechanism of CD59 influencing T cell signaling remained unclear. Here we analyzed Jurkat T cells stimulated via anti-CD3ε- or anti-CD59-coated surfaces, using time-resolved single-cell Ca(2+) imaging as a read-out for stimulation. This analysis revealed a heterogeneous Ca(2+) response of the cell population in a stimulus-dependent manner. Further analysis of T cell receptor (TCR)/CD3 deficient or overexpressing cells showed that CD59-mediated signaling is strongly dependent on TCR/CD3 surface expression. In protein co-patterning and fluorescence recovery after photobleaching experiments no direct physical interaction was observed between CD59 and CD3 at the plasma membrane upon anti-CD59 stimulation. However, siRNA-mediated protein knock-downs of downstream signaling molecules revealed that the Src family kinase Lck and the adaptor molecule linker of activated T cells (LAT) are essential for both signaling pathways. Furthermore, flow cytometry measurements showed that knock-down of Lck accelerates CD3 re-expression at the cell surface after anti-CD59 stimulation similar to what has been observed upon direct TCR/CD3 stimulation. Finally, physically linking Lck to CD3ζ completely abolished CD59-triggered Ca(2+) signaling, while signaling was still functional upon direct TCR/CD3 stimulation. Altogether, we demonstrate that Lck mediates signal transmission from CD59 to the TCR/CD3 pathway in Jurkat T cells, and propose that CD59 may act via Lck to modulate T cell responses.

  2. Separation for the determination of {sup 59/63}Ni in radioactive wastes

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Chang Heon; Choi, Kwang Soon; Jee, Kwang Young; Kim, Won Ho [KAERI, Daejon (Korea, Republic of); Jung, Kie Chul [ACT Co., Daejon (Korea, Republic of)

    2005-12-15

    A study on the separation of {sup 99}Tc, {sup 94}Nb, {sup 55}Fe, {sup 90}Sr and {sup 59/63}Ni in various radioactive wastes discharged from nuclear power plants has been performed for a use in their quantification which is indispensable for the evaluation of the radionuclide inventory. Ni was recovered along with Ca, Mg, Al, Cr, Ti, Mn, Ce, Na, K. and Cu through the sequential separation procedure of Re (as a surrogate of {sup 99}Tc), Nb, Fe and Sr by anion exchange and Sr-SPec extraction chromatography. In this research, chemical separation of Ni from the co-existing elements was investigated by cation exchange and Ni-Spec extraction chromatography. Precipitation behaviour of Ni and the co-existing elements with dimethylglyoxime(DMG) was investigated in ammonium citrate/ethanol-H{sub 2}O and tartaric acid/acetone-H{sub 2}O in order to purify separated Ni fractions and to prepare {sup 59/63}Ni source for the radioactivity measurement using a gas proportional counter. Recovery of Ni separated through ion exchange chromatographic separation procedure was 93.1% with relative standard deviation of 0.9%. In addition, recovery of Ni with DMG in the tartaric acid/acetone-H{sub 2}O was 85.6% with relative standard deviation of 1.9%.

  3. Search for varicella zoster virus DNA in saliva of healthy individuals aged 20-59 years.

    Science.gov (United States)

    Birlea, Marius; Cohrs, Randall J; Bos, Nathan; Mehta, Satish K; Pierson, Duane L; Gilden, Don

    2014-02-01

    All neurological and ocular complications of varicella zoster virus (VZV) reactivation can occur without rash. Virological verification requires detection of VZV DNA or anti-VZV IgG antibody in cerebrospinal fluid (CSF), or anti-VZV IgM antibody in serum or CSF. If VZV were readily detected in other tissue in patients with neurological disease without rash and found to correlate with tests listed above, more invasive tests such as lumbar puncture might be obviated. Saliva is a potential source of VZV DNA. To study the potential diagnostic value of detecting VZV DNA in saliva from patients with neurological disease, saliva of healthy adults was searched for VZV DNA. A single saliva sample obtained by passive drool was centrifuged at 16,000g for 20 min. DNA was extracted from the supernatant and cell pellet and examined in triplicate for VZV DNA by real time PCR. A single random saliva sample from 80 healthy men and women aged 20-59 years revealed no VZV DNA (Table ), but was uniformly positive for cell (GAPdH) DNA. Because VZV DNA was not found in a random saliva sample from 80 individuals 20-59-year-old, a VZV-positive sample during neurologic disease may have potential significance. Further studies will determine whether VZV DNA in saliva correlates with VZV DNA or anti-VZV antibody in CSF in patients with neurological disease. © 2013 Wiley Periodicals, Inc.

  4. Clarifications needed concerning the new Article 59 dealing with pleomorphic fungi.

    Science.gov (United States)

    Gams, Walter; Baral, Hans-Otto; Jaklitsch, Walter M; Kirschner, Roland; Stadler, Marc

    2012-12-01

    The new rules formulated in Article 59 of the International Code of Nomenclature for algae, fungi, and plants (ICN) will cause numerous, often undesirable, name changes, when only phylogenetically defined clades are named. Our task is to name fungal taxa and not just clades. Two suggestions are made here that may help to alleviate some disadvantages of the new system. (1) Officially an epithet coined in a list-demoted genus that is older than the oldest one available in the list-accepted genus would have to be recombined in the accepted genus. We recommend that individual authors and committees establishing lists of protected names should generally not recombine older epithets from a demoted genus into the accepted genus, when another one from pre-2013 is available in that genus. (2) Because the concepts of correlated teleomorph and anamorph genera are often incongruent, enforced congruence leads to a loss of information. Retaining the most suitable generic name is imperative, even when this is subordinated to another, list-accepted, generic name. Some kind of cryptic dual generic nomenclature is bound to persist. We therefore strongly recommend the retention of binomials in genera where they are most informative. With these recommendations, the upheaval of fungal nomenclature ensuing from the loss of the former Art. 59 can be reduced to an unavoidable minimum.

  5. Multiresidue analysis of 59 nonallowed substances and other contaminants in cosmetics.

    Science.gov (United States)

    Zhan, Jia; Ni, Mei-lin; Zhao, Hai-ying; Ge, Xiao-ming; He, Xiao-yu; Yin, Ju-yi; Yu, Xue-jun; Fan, Yuan-mu; Huang, Zhi-qiang

    2014-12-01

    A method was developed for the determination of 59 glucocorticoids, sex hormones, nonsteroidal anti-inflammatory drugs, antibiotics, and other contaminants in cosmetics simultaneously by ultra high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Acetonitrile was used to extract the sample, and the mixed sorbents were dispersed for purification. With the optimal conditions, the optimized pretreatment processes led to no significant interference on analysis from an extremely complicated sample matrix, and the linear ranges of 59 analytes were 0-480.0 μg/kg with the correlation coefficients above 0.99 and the limits of quantification (S/N≥10) were 5-40 μg/kg. Statistical evaluation revealed that the average recoveries were in the range of 61.2-131.2%, and relative standard deviations were in the range of 2.0-22.8%, meanwhile the interday precision ranged from 3.8 to 21.8%. This method is simple, fast, and credible, and it can be applied to simultaneous screening and determination of various classes of substances under investigations illegally presented in cosmetic products, covering a wide diversity of polarities, and pKa values. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Prognostic value of semiquantification NP-59 SPECT/CT in primary aldosteronism patients after adrenalectomy

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Ching-Chu; Cheng, Mei-Fang; Tzen, Kai-Yuan; Yen, Ruoh-Fang [National Taiwan University Hospital and National Taiwan University College of Medicine, Department of Nuclear Medicine, Taipei (China); Wu, Vin-Cent; Wu, Kwan-Dun [National Taiwan University Hospital and National Taiwan University College of Medicine, Department of Internal Medicine, Taipei (China); Liu, Kao-Lang [National Taiwan University Hospital and National Taiwan University College of Medicine, Department of Medical Imaging, Taipei (China); Lin, Wei-Chou [National Taiwan University Hospital and National Taiwan University College of Medicine, Department of Pathology, Taipei (China); Collaboration: the TAIPAI Study Group

    2014-07-15

    Primary aldosteronism (PA), characterized by an excessive production of aldosterone, affects 5-13 % of patients with hypertension. Accurate strategies are needed for the timely diagnosis of PA to allow curability and prevention of excessive cardiovascular events and related damage. This study aimed to evaluate the usefulness of semiquantification of {sup 131}I-6β-iodomethyl-norcholesterol (NP-59) single photon emission computed tomography (SPECT)/CT in differentiating aldosterone-producing adenoma (APA) from idiopathic adrenal hyperplasia (IAH) and in predicting clinical outcomes after adrenalectomy. We retrospectively reviewed 49 PA patients who had undergone adrenalectomy after NP-59 SPECT/CT within 1 year. A conventional visual scale (VS) and two semiquantitative parameters generated from SPECT/CT, adrenal to liver ratio (ALR) and lesion to contralateral ratio of bilateral adrenal glands (CON), with cutoff values calculated by receiver-operating characteristic (ROC) analysis, were compared with pathology results and postsurgical outcomes to determine the accuracy. An ALR cutoff of 1.84 and a CON cutoff of 1.15 showed an ability to distinguish adenoma from hyperplasia similar to VS (p = 0.2592 and 0.1908, respectively). An ALR cutoff of 2.28 and a CON cutoff of 1.11 yielded the highest sensitivity and specificity to predict postsurgical outcomes, and an ALR of 2.28 had an ability superior to VS (p = 0.0215), while a CON of 1.11 did not (p = 0.1015). Patients with either ALR or CON greater than the cutoff had a high probability of positive postsurgical outcomes (n = 36/38), while patients with both ALR and CON less than the cutoff had a low probability of positive postsurgical outcomes (n = 2/11). Semiquantification of NP-59 scintigraphy has an ability similar to VS in differentiating APA from IAH, but an excellent ability to predict postsurgical outcomes of adrenalectomy. An ALR or CON greater than the cutoff strongly suggests benefits from adrenalectomy, and

  7. Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59

    Directory of Open Access Journals (Sweden)

    Steven Johnson

    2013-05-01

    Full Text Available Pore-forming proteins containing the structurally conserved membrane attack complex/perforin fold play an important role in immunity and host-pathogen interactions. Intermedilysin (ILY is an archetypal member of a cholesterol-dependent cytolysin subclass that hijacks the complement receptor CD59 to make cytotoxic pores in human cells. ILY directly competes for the membrane attack complex binding site on CD59, rendering cells susceptible to complement lysis. To understand how these bacterial pores form in lipid bilayers and the role CD59 plays in complement regulation, we determined the crystal structure of human CD59 bound to ILY. Here, we show the ILY-CD59 complex at 3.5 Å resolution and identify two interfaces mediating this host-pathogen interaction. An ILY-derived peptide based on the binding site inhibits pore formation in a CD59-containing liposome model system. These data provide insight into how CD59 coordinates ILY monomers, nucleating an early prepore state, and suggest a potential mechanism of inhibition for the complement terminal pathway.

  8. The Green Bank Ammonia Survey: Unveiling the Dynamics of the Barnard 59 Star-forming Clump

    Science.gov (United States)

    Redaelli, E.; Alves, F. O.; Caselli, P.; Pineda, J. E.; Friesen, R. K.; Chacón-Tanarro, A.; Matzner, C. D.; Ginsburg, A.; Rosolowsky, E.; Keown, J.; Offner, S. S. R.; Di Francesco, J.; Kirk, H.; Myers, P. C.; Hacar, A.; Cimatti, A.; Chen, H. H.; Chen, M. C.; Lee, K. I.; Seo, Y. M.

    2017-12-01

    Understanding the early stages of star formation is a research field of ongoing development, both theoretically and observationally. In this context, molecular data have been continuously providing observational constraints on the gas dynamics at different excitation conditions and depths in the sources. We have investigated the Barnard 59 core, the only active site of star formation in the Pipe Nebula, to achieve a comprehensive view of the kinematic properties of the source. This information was derived by simultaneously fitting ammonia inversion transition lines (1, 1) and (2, 2). Our analysis unveils the imprint of protostellar feedback, such as increasing line widths, temperature, and turbulent motions in our molecular data. Combined with complementary observations of dust thermal emission, we estimate that the core is gravitationally bound following a virial analysis. If the core is not contracting, another source of internal pressure, most likely the magnetic field, is supporting it against gravitational collapse and limits its star formation efficiency.

  9. Complement factor H deficiency results in decreased neuroretinal expression of Cd59a in aged mice

    DEFF Research Database (Denmark)

    Faber, Carsten; Williams, Jennifer; Juel, Helene Bæk

    2012-01-01

    Purpose. The complement system is closely linked to the pathogenesis of AMD. Several complement genes are expressed in RPE, and complement proteins accumulate in drusen. Further, a common variant of complement factor H (CFH) confers increased risk of developing AMD. Because the mechanisms by which...... changes in the function of CFH influence development of AMD are unclear, we examined ocular complement expression as a consequence of age in control and CFH null mutant mice. Methods. Gene expression in neuroretinas and RPE/choroid from young and aged WT and Cfh−/− C57BL/6J mice was analyzed...... by microarrays. Expression of a wide range of complement genes was compared with expression in liver. Results. An age-associated increased expression of complement, particularly C1q, C3, and factor B, in the RPE/choroid coincided with increased expression of the negative regulators Cfh and Cd59a...

  10. Anterior fracture displacement in Colles’ fractures after Kapandji wiring in women over 59 years

    Science.gov (United States)

    Verdonk, René

    2006-01-01

    The aim of this study was to assess the radiological results of Colles’ fractures treated with Kapandji wiring and to determine the frequency of postoperative anterior fracture displacement. The X-rays of 89 fractures in women over 59 years of age were evaluated. Five weeks after injury, palmar shift of the distal fracture fragments and/or palmar tilt of more than 20° were observed in 26 patients. In ten wrists dorsal tilt was not sufficiently corrected and measured more than 10°. Increase in ulnar variance was more than 2 mm in 37 wrists and more than 5 mm in six wrists; this was more pronounced when the palmar tilt was not corrected properly or when anterior fracture displacement was present. We conclude that Kapandji wiring may not be able to prevent anterior fracture displacement in almost one-third of Colles’ fractures in osteoporotic elderly patients. PMID:16865364

  11. Molecular and clinical characteristics of clonal complex 59 methicillin-resistant Staphylococcus aureus infections in Mainland China.

    Directory of Open Access Journals (Sweden)

    Juan Li

    Full Text Available Detailed molecular analyses of Clonal Complex 59 (CC59 methicillin-resistant Staphylococcus aureus (MRSA isolates from children in seven major cities across Mainland China were examined. A total of 110 CC59 isolates from invasive and non-invasive diseases were analyzed by multilocus sequence typing (MLST, Staphylococcus cassette chromosome mec (SCCmec typing, staphylococcal protein A (spa typing and pulsed-field gel electrophoresis (PFGE. Antibiotics susceptibilities, carriage of plasmids and 42 virulence genes and the expression of virulence factors were examined. ST59 (101/110, 91.8% was the predominant sequence type (ST, while single locus variants (SLVs belonging to ST338 (8/110, 7.3% and ST375 (1/110, 0.9% were obtained. Three SCCmec types were found, namely type III (2.7%, type IV (74.5% and type V (22.7%. Seven spa types including t437, which accounted for 87.3%, were determined. Thirteen PFGE types were obtained. PFGE types A and B were the major types totally accounting for 81.8%. The dominant clone was ST59-t437-IVa (65.5%, followed by ST59-t437-V (14.5%. The positive rate of luks-PV and lukF-PV PVL encoding (pvl gene was 55.5%. Plasmids were detected in 83.6% (92/110 of the strains. The plasmid size ranging from 23.4 kb to 50 kb was most prevalent which accounted for 83.7% (77/92. A significantly lower expression of hla was found in ST59-t437-IVa compared with ST59-t437-V. Among the 110 cases, 61.8% of the patients were less than 1 year old. A total of 90 cases (81.8% were community-associated (CA infections whereas 20 cases (18.2% were hospital-associated (HA infections. Out of the 110 patients, 36.4% (40/110 were diagnosed with invasive infectious diseases in which ST59-t437-IVa accounted for 67.5% (27/40. In brief, ST59-t437-IVa was proved as the dominant clone in CC59 MRSA strains. The carriage rate of pvl gene was high. CC59 MRSA could result in CA and HA infections. The majortiy of MRSA infection children were in young age.

  12. Ectopic expression of the HAM59 gene causes homeotic transformations of reproductive organs in sunflower (Helianthus annuus L.).

    Science.gov (United States)

    Shulga, O A; Neskorodov, Ya B; Shchennikova, A V; Gaponenko, A K; Skryabin, K G

    2015-01-01

    The function of the HAM59 MADS-box gene in sunflower (Helianthus annuus L.) was studied to clarify homeotic C activity in the Asteraceae plant family. For the first time, transgenic sunflower plants with a modified pattern of HAM59 expression were obtained. It was shown that the HAM59 MADS-box transcription factor did mediate C activity in sunflower. In particular, it participated in termination of the floral meristem, repression of the cadastral function of A-activity, and together with other C-type sunflower protein HAM45-in the specification of the identity of stamens and pistils.

  13. Emergency care in 59 low- and middle-income countries: a systematic review

    Science.gov (United States)

    Abujaber, Samer; Makar, Maggie; Stoll, Samantha; Kayden, Stephanie R; Wallis, Lee A; Reynolds, Teri A

    2015-01-01

    Abstract Objective To conduct a systematic review of emergency care in low- and middle-income countries (LMICs). Methods We searched PubMed, CINAHL and World Health Organization (WHO) databases for reports describing facility-based emergency care and obtained unpublished data from a network of clinicians and researchers. We screened articles for inclusion based on their titles and abstracts in English or French. We extracted data on patient outcomes and demographics as well as facility and provider characteristics. Analyses were restricted to reports published from 1990 onwards. Findings We identified 195 reports concerning 192 facilities in 59 countries. Most were academically-affiliated hospitals in urban areas. The median mortality within emergency departments was 1.8% (interquartile range, IQR: 0.2–5.1%). Mortality was relatively high in paediatric facilities (median: 4.8%; IQR: 2.3–8.4%) and in sub-Saharan Africa (median: 3.4%; IQR: 0.5–6.3%). The median number of patients was 30 000 per year (IQR: 10 296–60 000), most of whom were young (median age: 35 years; IQR: 6.9–41.0) and male (median: 55.7%; IQR: 50.0–59.2%). Most facilities were staffed either by physicians-in-training or by physicians whose level of training was unspecified. Very few of these providers had specialist training in emergency care. Conclusion Available data on emergency care in LMICs indicate high patient loads and mortality, particularly in sub-Saharan Africa, where a substantial proportion of all deaths may occur in emergency departments. The combination of high volume and the urgency of treatment make emergency care an important area of focus for interventions aimed at reducing mortality in these settings. PMID:26478615

  14. Rad59-facilitated acquisition of Y' elements by short telomeres delays the onset of senescence.

    Directory of Open Access Journals (Sweden)

    Dmitri Churikov

    2014-11-01

    Full Text Available Telomerase-negative yeasts survive via one of the two Rad52-dependent recombination pathways, which have distinct genetic requirements. Although the telomere pattern of type I and type II survivors is well characterized, the mechanistic details of short telomere rearrangement into highly evolved pattern observed in survivors are still missing. Here, we analyze immediate events taking place at the abruptly shortened VII-L and native telomeres. We show that short telomeres engage in pairing with internal Rap1-bound TG1-3-like tracts present between subtelomeric X and Y' elements, which is followed by BIR-mediated non-reciprocal translocation of Y' element and terminal TG1-3 repeats from the donor end onto the shortened telomere. We found that choice of the Y' donor was not random, since both engineered telomere VII-L and native VI-R acquired Y' elements from partially overlapping sets of specific chromosome ends. Although short telomere repair was associated with transient delay in cell divisions, Y' translocation on native telomeres did not require Mec1-dependent checkpoint. Furthermore, the homeologous pairing between the terminal TG1-3 repeats at VII-L and internal repeats on other chromosome ends was largely independent of Rad51, but instead it was facilitated by Rad59 that stimulates Rad52 strand annealing activity. Therefore, Y' translocation events taking place during presenescence are genetically separable from Rad51-dependent Y' amplification process that occurs later during type I survivor formation. We show that Rad59-facilitated Y' translocations on X-only telomeres delay the onset of senescence while preparing ground for type I survivor formation.

  15. Prevalence of Urinary Incontinence in Women aged 20–59 years in Community Dwellings

    Directory of Open Access Journals (Sweden)

    Ratuafni Shafrina Wardani

    2017-06-01

    Full Text Available Background: Urinary incontinene (UI is the symptomof involuntary leakage of urine. Three types of urinary incontinence are stress UI, urge UI, and mixed UI. This study was aimed to determine the prevalence of urinary UI in women and to identify the most common type of UI. Methods: A descriptive study was conducted to 191 women age 20–59 in two villages in West Java, Indonesia. Subjects were visited door-to-door and interviewed using a standardized questionnaire for data collection. The study was conducted in February 2014. The variables of this study were age, parity, and the prevalence of urinary incontinence. The collected data were presented using frequency tabulation and percentage. Results: From 191 respondents, thirty eight subjects had UI. The prevalence of urinary incontinence was 19.90% which consisted of prevalence of stress UI (7.33%, urgency UI (9.43%, and mixed UI (3.14%. The prevalence of UI in 20–29 year age group was 3.23%, 30–39 year age group was 9.72%, 40–49 year age group was 27.69%, and 50–59 year age group was 52.17%. Prevalence of UI in nulliparous women was 5%, primiparous was 10.25%, multiparous with 2 childbirths was 23.61%, and multiparous with 3 childbirths or more was 26.67%. Conclusions: Prevalence of UI in women in community dwelling is 19.90%, which is higher than previous study from Indonesia and other Asian countries. Urgency UI is the most common type of UI. Prevalence of UI increases with age and parity.   DOI: 10.15850/amj.v4n2.1070

  16. Emergency care in 59 low- and middle-income countries: a systematic review.

    Science.gov (United States)

    Obermeyer, Ziad; Abujaber, Samer; Makar, Maggie; Stoll, Samantha; Kayden, Stephanie R; Wallis, Lee A; Reynolds, Teri A

    2015-08-01

    To conduct a systematic review of emergency care in low- and middle-income countries (LMICs). We searched PubMed, CINAHL and World Health Organization (WHO) databases for reports describing facility-based emergency care and obtained unpublished data from a network of clinicians and researchers. We screened articles for inclusion based on their titles and abstracts in English or French. We extracted data on patient outcomes and demographics as well as facility and provider characteristics. Analyses were restricted to reports published from 1990 onwards. We identified 195 reports concerning 192 facilities in 59 countries. Most were academically-affiliated hospitals in urban areas. The median mortality within emergency departments was 1.8% (interquartile range, IQR: 0.2-5.1%). Mortality was relatively high in paediatric facilities (median: 4.8%; IQR: 2.3-8.4%) and in sub-Saharan Africa (median: 3.4%; IQR: 0.5-6.3%). The median number of patients was 30 000 per year (IQR: 10 296-60 000), most of whom were young (median age: 35 years; IQR: 6.9-41.0) and male (median: 55.7%; IQR: 50.0-59.2%). Most facilities were staffed either by physicians-in-training or by physicians whose level of training was unspecified. Very few of these providers had specialist training in emergency care. Available data on emergency care in LMICs indicate high patient loads and mortality, particularly in sub-Saharan Africa, where a substantial proportion of all deaths may occur in emergency departments. The combination of high volume and the urgency of treatment make emergency care an important area of focus for interventions aimed at reducing mortality in these settings.

  17. 76 FR 13602 - Foreign-Trade Zone 59-Lincoln, NE; Application for Subzone; Cabela's Inc. (Hunting, Fishing...

    Science.gov (United States)

    2011-03-14

    ... 59, requesting special-purpose subzone status for the warehousing and distribution facilities of.... FTZ designation would further allow Cabela's to realize logistical benefits through the use of weekly...

  18. The terminal complement complex is generated in chronic leg ulcers in the absence of protectin (CD59)

    DEFF Research Database (Denmark)

    Balslev, E; Thomsen, H K; Danielsen, L

    1999-01-01

    -accelerating factor (CD55) and protectin (CD59). Eleven frozen biopsies from ischaemic leg ulcers, 10 biopsies from venous hypertension leg ulcers, and 10 biopsies from normal skin were studied. In 9 of 11 ischaemic and in 5 of 10 venous hypertension leg ulcers, marked staining for TCC was found around....... Semiquantitative measurement of CD59 showed marked increased staining intensity in the endothelium in venous hypertension ulcers and diminished intensity in ischaemic ulcers compared to normal skin. No such difference could be observed for CD55. When TCC was positive in the capillary walls, weak or no staining...... for CD59 was found. A significantly higher ratio of TCC/CD59 was found in the ischaemic compared to venous ulcers (p = 0.018). This was due to a marked difference between the ulcer margins (p = 0.013). Localized areas in the venous ulcers had the same pattern as that seen in the ischaemic ulcers. Our...

  19. Clinical evaluation of MPT-64 and MPT-59, two proteins secreted from Mycobacterium tuberculosis, for skin test reagents

    DEFF Research Database (Denmark)

    Wilcke, J T; Jensen, B N; Ravn, P

    1996-01-01

    SETTING: Department of Pulmonary Medicine P, Bispebjerg Hospital, Copenhagen, Denmark. OBJECTIVE: To study the ability of two proteins secreted from Mycobacterium tuberculosis, MPT-64 and MPT-59 to induce delayed type hypersensitivity (DTH) reactions following intradermal administration. DESIGN: ...

  20. ORA59 and EIN3 interaction couples jasmonate-ethylene synergistic action to antagonistic salicylic acid regulation of PDF expression.

    Science.gov (United States)

    He, Xiang; Jiang, Jishan; Wang, Chang-Quan; Dehesh, Katayoon

    2017-04-01

    Hormonal crosstalk is central for tailoring plant responses to the nature of challenges encountered. The role of antagonism between the two major defense hormones, salicylic acid (SA) and jasmonic acid (JA), and modulation of this interplay by ethylene (ET) in favor of JA signaling pathway in plant stress responses is well recognized, but the underlying mechanism is not fully understood. Here, we show the opposing function of two transcription factors, ethylene insensitive3 (EIN3) and EIN3-Like1 (EIL1), in SA-mediated suppression and JA-mediated activation of PLANT DEFENSIN1.2 (PDF1.2). This functional duality is mediated via their effect on protein, not transcript levels of the PDF1.2 transcriptional activator octadecanoid-responsive Arabidopsis59 (ORA59). Specifically, JA induces ORA59 protein levels independently of EIN3/EIL1, whereas SA reduces the protein levels dependently of EIN3/EIL1. Co-infiltration assays revealed nuclear co-localization of ORA59 and EIN3, and split-luciferase together with yeast-two-hybrid assays established their physical interaction. The functional ramification of the physical interaction is EIN3-dependent degradation of ORA59 by the 26S proteasome. These findings allude to SA-responsive reduction of ORA59 levels mediated by EIN3 binding to and targeting of ORA59 for degradation, thus nominating ORA59 pool as a coordination node for the antagonistic function of ET/JA and SA. © 2017 Institute of Botany, Chinese Academy of Sciences.

  1. Phosphorylation of SAF-A/hnRNP-U Serine 59 by Polo-Like Kinase 1 Is Required for Mitosis.

    Science.gov (United States)

    Douglas, Pauline; Ye, Ruiqiong; Morrice, Nicholas; Britton, Sébastien; Trinkle-Mulcahy, Laura; Lees-Miller, Susan P

    2015-08-01

    Scaffold attachment factor A (SAF-A), also called heterogenous nuclear ribonuclear protein U (hnRNP-U), is phosphorylated on serine 59 by the DNA-dependent protein kinase (DNA-PK) in response to DNA damage. Since SAF-A, DNA-PK catalytic subunit (DNA-PKcs), and protein phosphatase 6 (PP6), which interacts with DNA-PKcs, have all been shown to have roles in mitosis, we asked whether DNA-PKcs phosphorylates SAF-A in mitosis. We show that SAF-A is phosphorylated on serine 59 in mitosis, that phosphorylation requires polo-like kinase 1 (PLK1) rather than DNA-PKcs, that SAF-A interacts with PLK1 in nocodazole-treated cells, and that serine 59 is dephosphorylated by protein phosphatase 2A (PP2A) in mitosis. Moreover, cells expressing SAF-A in which serine 59 is mutated to alanine have multiple characteristics of aberrant mitoses, including misaligned chromosomes, lagging chromosomes, polylobed nuclei, and delayed passage through mitosis. Our findings identify serine 59 of SAF-A as a new target of both PLK1 and PP2A in mitosis and reveal that both phosphorylation and dephosphorylation of SAF-A serine 59 by PLK1 and PP2A, respectively, are required for accurate and timely exit from mitosis. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  2. Impact of colic surgery on return to function in racing Thoroughbreds: 59 cases (1996-2009).

    Science.gov (United States)

    Hart, Samantha K; Southwood, Louise L; Aceto, Helen W

    2014-01-15

    To determine the effect of colic surgery on return to function in Thoroughbred racehorses, identify clinical variables associated with successful return to racing, and compare racing performance between horses undergoing colic surgery and an untreated cohort. Retrospective cohort study. 59 Thoroughbred racehorses 2 to 5 years of age that underwent colic surgery and survived to hospital discharge and 90 untreated Thoroughbred racehorses equivalent in class. Medical records of patients evaluated for colic between January 1996 and July 2009 were reviewed, and horses with a Jockey Club Information Systems record were included. Physical examination and laboratory findings on hospital admission, lesion location and type, duration of surgery, duration of hospitalization, and any postoperative complications were recorded. The untreated cohort comprised 2 untreated horses randomly selected from runners in each treated horse's last race immediately prior to the date of colic surgery. Records were obtained from the Jockey Club Information Systems in April 2011. Only horses that raced at least once before and after surgery were included in the performance analysis. Number of starts, earnings per start, and total earnings were determined from race records for all horses. Quarterly earnings and number of starts for 12 quarters following the date of surgery were compared between treated and untreated horses via a Wilcoxon rank sum test. Longevity of racing was assessed by means of survival analysis. Poisson regression was used to compare rates of return to racing and active quarters aggregated across the first 12 quarters after surgery and for the available follow-up period for treated and untreated horses. 45 of 59 (76%) horses that raced prior to surgery returned to racing. Return to racing was significantly associated with admission heart rate and blood lactate concentration. From quarters 3 to 12, treated and untreated horses had slight differences in the number of starts but

  3. Vaccine adjuvant MF59 promotes the intranodal differentiation of antigen-loaded and activated monocyte-derived dendritic cells.

    Directory of Open Access Journals (Sweden)

    Rossella Cioncada

    Full Text Available MF59 is an oil-in-water emulsion adjuvant approved for human influenza vaccination in European Union. The mode of action of MF59 is not fully elucidated yet, but results from several years of investigation indicate that MF59 establishes an immunocompetent environment at injection site which promotes recruitment of immune cells, including antigen presenting cells (APCs, that are facilitated to engulf antigen and transport it to draining lymph node (dLN where the antigen is accumulated. In vitro studies showed that MF59 promotes the differentiation of monocytes to dendritic cells (Mo-DCs. Since after immunization with MF59, monocytes are rapidly recruited both at the injection site and in dLN and appear to have a morphological change toward a DC-like phenotype, we asked whether MF59 could play a role in inducing differentiation of Mo-DC in vivo. To address this question we immunized mice with the auto-fluorescent protein Phycoerythrin (PE as model antigen, in presence or absence of MF59. We measured the APC phenotype and their antigen uptake within dLNs, the antigen distribution within the dLN compartments and the humoral response to PE. In addition, using Ovalbumin as model antigen, we measured the capacity of dLN APCs to induce antigen-specific CD4 T cell proliferation. Here, we show, for the first time, that MF59 promotes differentiation of Mo-DCs within dLNs from intranodal recruited monocytes and we suggest that this differentiation could take place in the medullary compartment of the LN. In addition we show that the Mo-DC subset represents the major source of antigen-loaded and activated APCs within the dLN when immunizing with MF59. Interestingly, this finding correlates with the enhanced triggering of antigen-specific CD4 T cell response induced by LN APCs. This study therefore demonstrates that MF59 is able to promote an immunocompetent environment also directly within the dLN, offering a novel insight on the mechanism of action of

  4. KIR haplotypes defined by segregation analysis in 59 Centre d’Etude Polymorphisme Humain (CEPH) families

    Science.gov (United States)

    Martin, M. P.; Single, R. M.; Wilson, M. J.; Trowsdale, J.

    2012-01-01

    The killer cell immunoglobulin-like receptor (KIR) gene cluster exhibits extensive allelic and haplotypic diversity. Variation at the locus is associated with an increasing number of human diseases, reminiscent of the HLA loci. Characterization of diversity at the KIR locus has progressed over the past several years, particularly since the sequence of entire KIR haplotypes have become available. To determine the extent of KIR haplotypic variability among individuals of northern European descent, we genotyped 59 CEPH families for presence/absence of all KIR genes and performed limited allelic subtyping at several KIR loci. A total of 20 unique haplotypes differing in gene content were identified, the most common of which was the previously defined A haplotype (f=0.52). Several unusual haplotypes that probably arose as a consequence of unequal crossing over events were also identified. Linkage disequilibrium (LD) analysis indicated strong negative and positive LD between several pairs of genes, values that may be useful in determining haplotypic structure when family data are not available. These data provide a resource to aid in the interpretation of disease association data involving individuals of European descent. PMID:18972110

  5. KIR haplotypes defined by segregation analysis in 59 Centre d'Etude Polymorphisme Humain (CEPH) families.

    Science.gov (United States)

    Martin, M P; Single, R M; Wilson, M J; Trowsdale, J; Carrington, M

    2008-12-01

    The killer cell immunoglobulin-like receptor (KIR) gene cluster exhibits extensive allelic and haplotypic diversity. Variation at the locus is associated with an increasing number of human diseases, reminiscent of the HLA loci. Characterization of diversity at the KIR locus has progressed over the past several years, particularly since the sequence of entire KIR haplotypes have become available. To determine the extent of KIR haplotypic variability among individuals of northern European descent, we genotyped 59 CEPH families for presence/absence of all KIR genes and performed limited allelic subtyping at several KIR loci. A total of 20 unique haplotypes differing in gene content were identified, the most common of which was the previously defined A haplotype (f = 0.52). Several unusual haplotypes that probably arose as a consequence of unequal crossing over events were also identified. Linkage disequilibrium (LD) analysis indicated strong negative and positive LD between several pairs of genes, values that may be useful in determining haplotypic structure when family data are not available. These data provide a resource to aid in the interpretation of disease association data involving individuals of European descent.

  6. Rare Chromones from a Fungal Mutant of the Marine-Derived Penicillium purpurogenum G59

    Directory of Open Access Journals (Sweden)

    Ming-Wen Xia

    2015-08-01

    Full Text Available Three new and rare chromones, named epiremisporine B (2, epiremisporine B1 (3 and isoconiochaetone C (4, along with three known remisporine B (1, coniochaetone A (5 and methyl 8-hydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate (6 were isolated from a mutant from the diethyl sulfate (DES mutagenesis of a marine-derived Penicillium purpurogenum G59. The structures of 2–4 including the absolute configurations were determined by spectroscopic methods, especially by NMR analysis and electronic circular dichroism (ECD experiments in conjunction with calculations. The absolute configuration of the known remisporine B (1 was determined for the first time. Compounds 2 and 3 have a rare feature that has only been reported in one example so far. The compounds 1–6 were evaluated for their cytotoxicity against several human cancer cell lines. The present work explored the great potential of our previous DES mutagenesis strategy for activating silent fungal pathways, which has accelerated the discovery of new bioactive compounds.

  7. Efficacy and acceptability of outpatient, single-visit, medical abortion up to 59 days of gestation

    Directory of Open Access Journals (Sweden)

    Manisha Agarwal

    2010-11-01

    Full Text Available Manisha AgarwalDepartment of Obstetrics and Gynecology, Mahatma Gandhi Medical College and Research Institute, Pillaiyarkuppam, Pondicherry, IndiaAbstract: This study evaluated the efficacy and acceptability of medical abortion by a modified, single-visit treatment regimen for termination of early (up to 59 days pregnancy. The study population included 160 women. They were vaginally administered misoprostol 600 mg six hours after oral administration of mifepristone 200 µg. Patients’ symptoms were evaluated by telephone, and they were counseled accordingly. Follow-up sonography was performed two weeks later. The reasons patients chose this method were to avoid hospitalization, preference for a natural and noninvasive method, and confidentiality (55%. Side effects were mainly mild abdominal cramps (45% and prolonged bleeding (2.4%. The success rate of complete abortion was 98.12%, with 1.25% of these patients needing a second vaginal dose to complete the treatment. The single-visit medical abortion method is acceptable and efficacious for women in developing countries.Keywords: medical abortion, mifepristone, misoprostol, administration, intravaginal

  8. Selective separation of {sup 59}/{sup 63}Ni from radioactive wastes

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Chang Heon; Choi, Kwang Soon; Jee, Kwang Yong; Kim, Won Ho [Korea Atomic Energy Research Institute, Taejeon (Korea, Republic of); Jung, Kie Chul [Atomic Creative Technology Co., Taejeon (Korea, Republic of)

    2005-06-15

    A study on the selective separation of {sup 99}Tc, {sup 94}Nb, {sup 55}Fe, {sup 90}Sr and {sup 59}Ni({sup 63}Ni) from various radioactive wastes discharged from the nuclear power plants in Korea is being performed for use in their quantifications which are indispensable for the evaluation of the radionuclide inventory. Separation behaviour of Ce, Ca, Mg, AI, Cr, Ti, Mn and Cu recovered along with Ni during the separation of Re (as a surrogate of {sup 99}Tc), Nb, Fe and Sr by anion exchange and Sr--Spec extraction chromatography was investigated by cation exchange and Ni-Spec extraction chromatography using synthetic radioactive waste dissolved solutions containing matrix elements such as Re, Nb, Fe, Sr, Ni, B, Na, K, Ce Co. Ca, Mg, Al, Zn. Cr, Pb, Cd, Mo, Mn, Cu, Zr, Ti and U. To purify the Ni fraction recovered and prepare a radionuclide source available for gas proportional counting, an application of the Ni precipitation procedure with dimethylglyoxime in the medium of ammonium citrate and tartaric acid solutions as a masking agent for co-existing metal ions was described in detail.

  9. Photoneutron cross sections for {sup 59}Co. Systematic uncertainties of data from various experiments

    Energy Technology Data Exchange (ETDEWEB)

    Varlamov, V.V. [Lomonosov Moscow State University, Skobeltsyn Institute of Nuclear Physics, Moscow (Russian Federation); Davydov, A.I. [Lomonosov Moscow State University, Physics Faculty, Moscow (Russian Federation); Ishkhanov, B.S. [Lomonosov Moscow State University, Skobeltsyn Institute of Nuclear Physics, Moscow (Russian Federation); Lomonosov Moscow State University, Physics Faculty, Moscow (Russian Federation)

    2017-09-15

    Data on partial photoneutron reaction cross sections (γ, 1n), (γ, 2n), and (γ, 3n) for {sup 59}Co obtained in two experiments carried out at Livermore (USA) were analyzed. The sources of radiation in both experiments were the monoenergetic photon beams from the annihilation in flight of relativistic positrons. The total yield was sorted by the neutron multiplicity, taking into account the difference in the neutron energy spectra for different multiplicity. The two quoted studies differ in the method of determining the neutron. Significant systematic disagreements between the results of the two experiments exist. They are considered to be caused by large systematic uncertainties in partial cross sections, since they do not satisfy physical criteria for reliability of the data. To obtain reliable cross sections of partial and total photoneutron reactions a new method combining experimental data and theoretical evaluation was used. It is based on the experimental neutron yield cross section which is rather independent of neutron multiplicity and the transitional neutron multiplicity functions of the combined photonucleon reaction model (CPNRM). The model transitional multiplicity functions were used for the decomposition of the neutron yield cross section into the contributions of partial reactions. The results of the new evaluation noticeably differ from the partial cross sections obtained in the two experimental studies are under discussion. (orig.)

  10. Establishing geochemical background variation and threshold values for 59 elements in Australian surface soil.

    Science.gov (United States)

    Reimann, Clemens; de Caritat, Patrice

    2017-02-01

    During the National Geochemical Survey of Australia over 1300 top (0-10cm depth) and bottom (~60-80cm depth) sediment samples (including ~10% field duplicates) were collected from the outlet of 1186 catchments covering 81% of the continent at an average sample density of 1 site/5200km 2 . The PTEs), in Australian surface soil. Different methods of obtaining geochemical threshold values, which differentiate between background and those samples with unusually high element concentrations and requiring attention, are presented and compared to Western Australia's 'ecological investigation levels' (EILs) established for 14 PTEs. For Mn and V these EILs are so low that an unrealistically large proportion (~24%) of the sampled sites would need investigation in Australia. For the 12 remaining elements (As, Ba, Cd, Co, Cr, Cu, Hg, Mo, Ni, Pb, Sn and Zn) few sample sites require investigation and as most of these are located far from human activity centres, they potentially suggest either minor local contamination or mineral exploration potential rather than pollution. No major diffuse source of contamination by PTEs affects Australian soil at the continental scale. Of the statistical methods used to establish geochemical threshold values, the most pertinent results come from identifying breaks in cumulative probability distributions, the Tukey inner fence and the 98th percentile. Geochemical threshold values for 59 elements, including emerging 'high-tech' critical elements such as lanthanides, Be, Ga or Ge, for which no EILs currently exist, are presented. Crown Copyright © 2016. Published by Elsevier B.V. All rights reserved.

  11. Prognostic significance of new immunohistochemical markers in refractory classical Hodgkin lymphoma: a study of 59 cases.

    Directory of Open Access Journals (Sweden)

    Danielle Canioni

    Full Text Available Although most classical Hodgkin lymphoma patients are cured, a significant minority fail after primary therapy and may die as result of their disease. To date, there is no consensus on biological markers that add value to usual parameters (which comprise the International Prognostic Score used at diagnosis to predict outcome. We evaluated 59 patients (18 with primary refractory or early relapse disease and 41 responders for bcl2, Ki67, CD20, TiA1 and c-kit expression by semi-quantitative immunohistochemical study and correlated the results with the response to treatment.The results showed that expression of bcl2 and CD20 in Hodgkin and Reed Sternberg cells, and expression of TiA1 in micro-environmental lymphocytes, and c-kit positive mast cells in microenvironment, were independent prognostic markers. These novel cHL markers could be used in association with clinical parameters to identify newly diagnosed patients with favorable or unfavorable prognosis and to better tailor treatment for different risk groups.

  12. Source complexity of the May 20, 2012, Mw 5.9, Ferrara (Italy event

    Directory of Open Access Journals (Sweden)

    Davide Piccinini

    2012-10-01

    Full Text Available A Mw 3.9 foreshock on May 19, 2012, at 23:13 UTC, was followed at 02:03 on May 20, 2012, by a Mw 5.9 earthquake that hit a densely populated area in the Po Plain, west of the city of Ferrara, Italy (Figure 1. Over the subsequent 13 days, six Mw >5 events occurred; of these, the most energetic was a Mw 5.8 earthquake on May 29, 2012, 12 km WSW of the main shock. The tragic balance of this sequence was 17 casualties, hundreds of injured, and severe damage to the historical and cultural heritage of the area. From a seismological point of view, the 2012 earthquake was not an outstanding event in its regional context. The same area was hit in 1996 by a Mw 5.4 earthquake [Selvaggi et al. 2001], and previously in 1986 and in 1967 (DBMI11 [Locati et al. 2011]. The most destructive historical event was the 1570, Imax 8 event, which struck the town of Ferrara [Guidoboni et al. 2007, Rovida et al. 2011]. The 2012 seismic sequence lasted for several weeks and probably developed on a well-known buried thrust fault [Basili et al. 2008, Toscani et al. 2009, DISS Working Group 2010], at depths between 2 km and 10-12 km. […

  13. c21orf59/kurly Controls Both Cilia Motility and Polarization

    Directory of Open Access Journals (Sweden)

    Kimberly M. Jaffe

    2016-03-01

    Full Text Available Cilia are microtubule-based projections that function in the movement of extracellular fluid. This requires cilia to be: (1 motile and driven by dynein complexes and (2 correctly polarized on the surface of cells, which requires planar cell polarity (PCP. Few factors that regulate both processes have been discovered. We reveal that C21orf59/Kurly (Kur, a cytoplasmic protein with some enrichment at the base of cilia, is needed for motility; zebrafish mutants exhibit characteristic developmental abnormalities and dynein arm defects. kur was also required for proper cilia polarization in the zebrafish kidney and the larval skin of Xenopus laevis. CRISPR/Cas9 coupled with homologous recombination to disrupt the endogenous kur locus in Xenopus resulted in the asymmetric localization of the PCP protein Prickle2 being lost in mutant multiciliated cells. Kur also makes interactions with other PCP components, including Disheveled. This supports a model wherein Kur plays a dual role in cilia motility and polarization.

  14. Protection from radon exposure at home and at work in the directive 2013/59/Euratom.

    Science.gov (United States)

    Bochicchio, F

    2014-07-01

    In recent years, international organisations involved in radiation protection and public health have produced new guidance, recommendations and requirements aiming better protection from radon exposure. These organisations have often worked in close collaboration in order to facilitate the establishment of harmonised standards. This paper deals with such standards and specifically with the new European Council Directive of 5 December 2013 on basic safety standards for protection against the dangers arising from exposure to ionising radiation (2013/59/Euratom). This new Directive has established a harmonised framework for the protection against ionising radiations, including protection from radon exposure. Requirements for radon in workplace are much more tightening than in previous Directive, and exposures to radon in dwellings are regulated for the first time in a Directive. Radon-related articles of this Directive are presented and discussed in this paper, along with some comparisons with other relevant international standards. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  15. Midterm results of endovascular treatment of iliac artery lesions: analysis of 59 cases

    Directory of Open Access Journals (Sweden)

    Leonardo Ghizoni Bez

    2013-06-01

    Full Text Available BACKGROUND: Endovascular treatment of peripheral arterial occlusive disease has become increasingly frequent in the past few years. Because it is a less invasive procedure, lower morbidity and mortality rates are associated with this form of treatment. OBJECTIVES: To describe the endovascular procedures performed in iliac arteries for the treatment of peripheral arterial occlusive disease. METHODS: This retrospective study assesses 59 cases of iliac artery angioplasty performed according to a specific protocol from January 2004 to February 2010. RESULTS: Mean age of patients was 62 years (minimum: 42, maximum: 89. Thirty seven were male (62.72% and 22 female (37.28%. The main indications for treatment were moderate to severe intermittent claudication in 30 cases (50.84% and rest pain or trophic lesions (critical ischemia in 29 cases (49.15%. Postoperative follow-up included ankle-brachial index measurements and a duplex ultrasound at 30 days, 3 months, 6 months, 12 months, and every 6 months thereafter. Minimum follow-up time was 3 months, and maximum, 72 months (6 years, with primary and secondary patency rates of 91.37 and 94.82%, respectively. CONCLUSIONS: The results of this case series, combined with literature review results, allow to conclude that the endovascular approach is an effective and safe option to treat peripheral arterial occlusive disease in iliac arteries.

  16. Risk Factors of Underweight in Children Aged 6–59 Months in Ethiopia

    Directory of Open Access Journals (Sweden)

    Deneke Tosheno

    2017-01-01

    Full Text Available Background. Undernutrition in early childhood has irreversible and long-lasting implications. Hence, this study was aimed at assessing risk factors of child undernutrition. Methods. A community-based cross-sectional study was conducted on 642 households with mothers to children pairs aged 6–59 months selected by a multistage systematic random sampling method. Child anthropometric measurements on weight were recorded using standardized and calibrated weighing scales. Weight-for-age was compared to the 2007 WHO growth reference by WHO Anthro software. Data were entered using Epi-Info and analyzed using SPSS. Bivariate and multivariate logistic regression analyses were used to evaluate the association between underweight children and their predictors; both crude and adjusted odds ratios with 95% confidence interval were reported. Results. One-fourth (25% of the children were underweight. Child age (AOR: 2.36, gender (AOR: 1.82, illness (AOR: 0.09, maternal decision making power (AOR: 0.07, maternal education (AOR: 0.19, employment/occupation (AOR: 5.29, and household income (AOR: 4.16 were found to be independent and significant predictors of underweight children. Conclusion. Significant proportion of the children were underweight. Maternal decision-making power persists as a strong predictor of children’s weight. Therefore, intervention programs focusing on improving mothers’ decision-making power on child nutrition would contribute to the efforts towards alleviating the problem.

  17. C5 Palsy After Cervical Spine Surgery: A Multicenter Retrospective Review of 59 Cases.

    Science.gov (United States)

    Thompson, Sara E; Smith, Zachary A; Hsu, Wellington K; Nassr, Ahmad; Mroz, Thomas E; Fish, David E; Wang, Jeffrey C; Fehlings, Michael G; Tannoury, Chadi A; Tannoury, Tony; Tortolani, P Justin; Traynelis, Vincent C; Gokaslan, Ziya; Hilibrand, Alan S; Isaacs, Robert E; Mummaneni, Praveen V; Chou, Dean; Qureshi, Sheeraz A; Cho, Samuel K; Baird, Evan O; Sasso, Rick C; Arnold, Paul M; Buser, Zorica; Bydon, Mohamad; Clarke, Michelle J; De Giacomo, Anthony F; Derakhshan, Adeeb; Jobse, Bruce; Lord, Elizabeth L; Lubelski, Daniel; Massicotte, Eric M; Steinmetz, Michael P; Smith, Gabriel A; Pace, Jonathan; Corriveau, Mark; Lee, Sungho; Cha, Peter I; Chatterjee, Dhananjay; Gee, Erica L; Mayer, Erik N; McBride, Owen J; Roe, Allison K; Yanez, Marisa Y; Stroh, D Alex; Than, Khoi D; Riew, K Daniel

    2017-04-01

    A multicenter, retrospective review of C5 palsy after cervical spine surgery. Postoperative C5 palsy is a known complication of cervical decompressive spinal surgery. The goal of this study was to review the incidence, patient characteristics, and outcome of C5 palsy in patients undergoing cervical spine surgery. We conducted a multicenter, retrospective review of 13 946 patients across 21 centers who received cervical spine surgery (levels C2 to C7) between January 1, 2005, and December 31, 2011, inclusive. P values were calculated using 2-sample t test for continuous variables and χ2 tests or Fisher exact tests for categorical variables. Of the 13 946 cases reviewed, 59 patients experienced a postoperative C5 palsy. The incidence rate across the 21 sites ranged from 0% to 2.5%. At most recent follow-up, 32 patients reported complete resolution of symptoms (54.2%), 15 had symptoms resolve with residual effects (25.4%), 10 patients did not recover (17.0%), and 2 were lost to follow-up (3.4%). C5 palsy occurred in all surgical approaches and across a variety of diagnoses. The majority of patients had full recovery or recovery with residual effects. This study represents the largest series of North American patients reviewed to date.

  18. [Various types of anemia in children of 6 to 59 months].

    Science.gov (United States)

    Ben Jaâfar, Sonia Khosrof; Kamoun, Abdelaziz; El Ati, Jalila; Gharbi, Najoua; Fazaâ, Saloua; Gaigi, Sadok

    2007-02-01

    To assess the different kinds of anaemia in childhood 468 children of Large Tunis and 487 children of the Western South like 744 of the urban environment and 211 children of the rural medium were studied. 21.3% of the old children from 6 to 59 months of Large Tunis present a ferriprive anaemia and 18% for the Western South. 20.7% of the children of the urban environment present against a ferriprive anaemia 19.1% for the rural medium but these results remain non significant. 1.1% of the children of Large Tunis present a martial anaemia associated with an ignition and 0.6% of the surveyed children are touched by this type of anaemia in the Western South. This association touches especially the urban environment with a rate of 1.1% against 0% for the rural medium. The proportion of the feeble children by deficiency in folic acid remains very low as for that by deficiency in B12 vitamin. The majority of the children of Large Tunis (2.9%) are touched by B minor thalassaemia and 1.3% of the children of the Western South are touched by the feature drépanocytaire. The major cause of anaemia for the children of less than 5 years thus remains ferriprive.

  19. Do hormonal contraceptives stimulate growth of neurofibromas? A survey on 59 NF1 patients

    Directory of Open Access Journals (Sweden)

    Mautner Victor-Felix

    2005-02-01

    Full Text Available Abstract Background Neurofibromas are benign tumors of the peripheral nerves and hallmark of neurofibromatosis type 1 (NF1, a tumor suppressor gene syndrome. Neurofibromas mostly start developing at puberty and can increase in size and number during pregnancy. Expression of progesterone receptors has been found in 75% of the tumors. Many female NF1 patients are thus concerned about the possibility that hormonal contraceptives may stimulate the growth of their neurofibromas. Methods A survey was carried out on 59 female NF1 patients who are practicing or have practiced hormonal contraception to examine the effect of the various contraceptives on the growth of neurofibromas. Results Majority (53 out of 58 of patients who received oral estrogen-progestogen or pure progestogen preparations reported no associated tumor growth. In contrast, significant tumor growth was reported by two patients who received depot contraceptive containing high dose of synthetic progesterone. Conclusions Oral contraceptives do not seem to stimulate the growth of neurofibromas in NF1 patients. High doses of progesterone might stimulate the growth of neurofibromas and deserve more caution.

  20. Effectiveness of MF59-adjuvanted seasonal influenza vaccine in the elderly: A systematic review and meta-analysis.

    Science.gov (United States)

    Domnich, Alexander; Arata, Lucia; Amicizia, Daniela; Puig-Barberà, Joan; Gasparini, Roberto; Panatto, Donatella

    2017-01-23

    In the elderly, traditional influenza inactivated vaccines are often only modestly immunogenic, owing to immunosenescence. Given that adjuvantation is a means of enhancing the immune response, the trivalent inactivated vaccine adjuvanted with MF59 (MF59-TIV) was specifically designed to overcome this problem. Considering that, for ethical reasons, the absolute effectiveness of an influenza vaccine in the elderly cannot be demonstrated in placebo-controlled studies, the present study aimed to assess the effectiveness of MF59-TIV in preventing influenza-related outcomes in the elderly. We conducted a systematic review of observational studies aimed at evaluating the effectiveness of MF59-TIV against influenza-related outcomes. Results of single studies were pooled whenever possible. Of the 1993 papers screened, 11 (6 case-control, 3 cohort and 2 prospective case-control) studies were identified. Hospitalization due to pneumonia/influenza and laboratory-confirmed influenza were reported in more than one study, while other outcomes (influenza-like illness, cardio- and cerebrovascular accidents) were investigated only by one study each. Pooled analysis of four case-control studies showed an adjusted MF59-TIV effectiveness of 51% (95% CI: 39-61%) against hospitalizations for pneumonia/influenza among community-dwelling seniors. Pooled results of the adjusted vaccine effectiveness against laboratory-confirmed influenza were also high (60.1%), although the 95% CI passed through zero (-1.3 to 84.3%). Other single community-based studies showed very high effectiveness of MF59-TIV in preventing hospitalizations for acute coronary [87% (95% CI: 35-97%)] and cerebrovascular [93% (95% CI: 52-99%)] events. MF59-TIV proved highly effective [94% (95% CI: 47-100%] in reducing influenza-like illness among institutionalized elderly. Furthermore, MF59-TIV displayed greater efficacy than non-adjuvanted vaccines in preventing hospitalizations due to pneumonia/influenza [adjusted risk

  1. C1q nephropathy and isolated CD59 deficiency manifesting as necrotizing crescentic glomerulonephritis: A rare association of two diseases

    Directory of Open Access Journals (Sweden)

    Ruchika Gupta

    2015-01-01

    Full Text Available C1q nephropathy is a recently described clinico-pathologic entity with a variable clinical presentation and pathology. Crescentic glomerulonephritis (GN has been reported in only two patients in the available literature. CD59 deficiency, along with lack of CD55, is responsible for paroxysmal nocturnal hemoglobinuria (PNH. Few cases of isolated CD59 deficiency have been described with PNH-like features. A middle-aged adult male presented with rapidly progressive renal failure. Serological investigations were negative. A renal biopsy revealed necrotizing crescentic GN with rupture of Bowman′s capsule. Immunofluorescence on the frozen sections showed dominant mesangial deposits of C1q along with IgM. Hematological work-up of the patient revealed isolated CD59 deficiency. Hence, a final diagnosis of C1q nephropathy and CD59 deficiency manifesting as crescentic GN and hemolytic anemia was made. The co-existence of two rare disorders, C1q nephropathy and CD59 deficiency, in a patient with necrotizing crescentic GN is described for the first time to the best of our knowledge. The pathogenetic link of these two entities with the clinical manifestation requires further study.

  2. Solid-state C-13 and Co-59 NMR spectroscopy of C-13-methylcobalt(III) complexes with amine ligands

    DEFF Research Database (Denmark)

    Ooms, Kristopher J.; Bernard, Guy M.; Kadziola, Anders

    2009-01-01

    spectroscopy, which also established the negative sign of C-Q(Co-59). Cobalt-59 NMR spectroscopy was used to characterize the cobalt magnetic shielding tensor, to verify the magnitudes of C-Q(Co-59) and to establish the value of eta(Q), which is difficult to determine indirectly. The measurements show...... that the EFG tensors are either axially symmetric or close to being so but there is a wide range of C-Q values, from -40 MHz for the complex with X = H2O to -105 MHz with X = CN-. The Co chemical shift tensors are approximately axially symmetric with the spans. delta(11) - delta(33), ranging from 3700 to 5600...... ppm for X = H2O and CN-, respectively. The latter measurements also established the relative orientations of the Co EFG and chemical shift tensors. Density functional theory calculations of the Co-59 EFG and magnetic shielding tensors as well as of (1)J(Co-59, C-13) for the NO2- and N-3(-) complexes...

  3. 31P Differential Line Broadening in the Presence of the 59Co Quadrupolar-CSA Interference in Tetrahedral Clusters

    Science.gov (United States)

    Granger, Pierre; Elbayed, Karim; Raya, Jésus; Kempgens, Pierre; Rosé, Jacky

    The first investigation and analysis of the effects, theoretically predicted by Werbelow et al.[ J. Chem. Soc. Faraday Trans.83, 871 (1987)], of interference terms on the lineshape of a spin 1/2 coupled to a high-spin nucleus undergoing quadrupolar and chemical-shift anisotropy (CSA) relaxations are reported for three tetrahedral clusters HFeCo 3(CO) 11L with L = PPh 2H (1), L = PCy 2H (2), and L = PPh 3(3) (Cy = cyclohexyl). For these clusters in solution, an unusual asymmetric broad NMR multiplet of the 31P nucleus scalar-coupled to a 59Co nucleus is observed. It is shown that the 59Co CSA-quadrupolar interference term is the origin of the asymmetry of the 31P spectra. The analysis of the lineshape of the 1H-decoupled spectra gives the spin-coupling constants 1J( 31P- 59Co) and the CSA contribution to the 59Co relaxation. Experimental measurements of T1and of the linewidths for cobalt-59 are reported and support these findings.

  4. Syndromes of collateral-reported psychopathology for ages 18-59 in 18 Societies

    Directory of Open Access Journals (Sweden)

    Masha Y. Ivanova

    2015-01-01

    Full Text Available El objetivo del presente estudio fue avanzar en la metodología clínica y de investigación relativa a la evaluación psicopatológica poniendo a prueba la generalización internacional de un modelo de ocho síndromes derivado de evaluaciones de personas allegadas a adultos sobre los problemas emocionales, sociales y de pensamiento y conducta de dichos adultos. Informantes allegados a los adultos calificaron a 8.582 residentes de 18 países con edades comprendidas entre 18 y 59 años con el Adult Behavior Checklist(ABCL. Mediante un análisis factorial confirmatorio se examinó el ajuste del modelo de ocho síndromes a las puntuaciones provenientes de cada país. El índice primario de ajuste del modelo (RMSEA mostró un buen ajuste del modelo en todos los países, mientras que índices secundarios (Comparative Fit Index Tucker-Lewis Index mostraron un ajuste de aceptable a bueno en 17 países. Se obtuvieron cargas factoriales robustas para los distintos países e ítems. De los 5.007 parámetros estimados, cuatro (0,08 % se encontraban fuera de rango. No obstante, los intervalos de confianza del 95% comprendían el espacio admisible, indicando que la desviación de los cuatro parámetros podría deberse a fluctuaciones en el muestreo. Los hallazgos coinciden con la evidencia previa existente sobre la generalización del modelo de ocho síndromes obtenida de autoinformes realizados en 28 sociedades. Además, los resultados indican que el modelo es adecuado para operacionalizar fenotipos de la psicopatología del adulto a partir de evaluaciones de múltiples informantes en diversas sociedades.

  5. Cubital tunnel syndrome caused by ganglion cysts: a review of 59 cases.

    Science.gov (United States)

    Tong, Jinsong; Xu, Bin; Dong, Zhen; Liu, Jingbo; Zhang, Chenggang; Gu, Yudong

    2017-07-01

    Cubital tunnel syndrome caused by ganglion cysts is rare and reports are few. This study aimed to review a patient cohort with ganglion cysts in the cubital tunnel and identify prognostic factors. Fifty-seven patients (59 extremities; McGowan grade I, 4; IIa, 4; IIb, 3; III, 48) were evaluated retrospectively with a minimum follow-up of 2 years. Extraneural cysts were excised completely, while intraneural cysts were incised and drained. All cases underwent subcutaneous transposition. Spearman's rank correlation and the ordinal logistic regression model were used to assess the effect of independent variables on the postoperative McGowan grade. VAS pain and weakness, 2-PD, key-pinch strength, grip strength, first dorsal interosseous muscle strength, Wartenberg sign, and claw hand all improved significantly. DASH scores improved from an average of 43.8 points preoperatively to 10.7 points postoperatively. According to the modified Bishop scoring system, 55 extremities (93.2%) were graded good or excellent. At the last follow-up, 29 hands (49.2%) returned to normal, and improvement by at least one McGowan grade was reached in 51 cases (86.4%). Older age, smoking, and shorter postoperative follow-up were associated with a higher postoperative McGowan grade. Satisfactory surgical outcomes could be expected in these patients following subcutaneous transposition with excision of extraneural cysts and draining of intraneural cysts. Older age, smoking, and shorter postoperative follow-up were found to be independent risk factors for poor outcomes.

  6. DEVELOPING MODELS TO PREDICT STUNTING AMONG 6-59 MONTHS CHILDREN IN A SLUM OF KOLKATA

    Directory of Open Access Journals (Sweden)

    Ranadip Chowdhury

    2013-12-01

    Full Text Available Background: India is one among the many countries where child malnutrition is severe and is a major underlying cause of child mortality.  48 per cent of under five children in India are stunted and India accounts for more than 3 out of every 10 stunted children in the world. Even after implementation of the national nutritional programmes the magnitude of the problem remains at large, this necessitates a detailed analysis regarding the factors leading to stunting and to identify which group of factors to target first to make a significant effect.Methods: This  Community  based  cross-sectional  study was done  in  the service area of  Urban  Training  Centre  in  Baghbazar,  Kolkata  with  84  children  aged  6-59  months. Anthropometric measurements of the study population were done  using  standard methods and information regarding risk factors were collected from their parents using a pre-designed questionnaire. WHO Anthro for personal computers version3.2.2 (Z score and SPSS version16.0 was used to analyse the data (multivariate logistic regression and ROC curve.  Results: The study indicates a 26.2% prevalence of stunting among the study population. To observe the risk factors for stunting two models were compared by creating ROC curves, a socio demographic factor model which explained 70% of the stunting in the population in comparison to the second model regarding the factors related to birth and feeding practices which explained 65%. Conclusion: The current study further emphasizes the need to implement relevant interventions to combat malnutrition in this region and other similar settings.

  7. Hydrology of area 59, northern Great Plains and Rocky Mountain coal provinces, Colorado and Wyoming

    Science.gov (United States)

    Gaggiani, Neville G.; Britton, Linda J.; Minges, Donald R.; Kilpatrick, F.A.; Parker, Randolph S.; Kircher, James E.

    1987-01-01

    Hydrologic information and analysis aid in decisions to lease federally owned coal and to prepare necessary Environmental Assessments and Impact Study reports. This need has become even more critical with the enactment of Public Law 95-87, the "Surface Mining Control and Reclamation Act of 1977." This act requires an appropriate regulatory agency to issue permits, based on the review of permit-application data to assess hydrologic impacts. This report, which partially fulfills this requirement, is one in a series of nationwide coal province reports that present information thematically, through the use of a brief text and accompanying maps, graphs, charts, or other illustrations for single hydrologic topics. The report broadly characterizes the hydrology of Area 59 in north-central Colorado and southeastern Wyoming.The report area, located within the South Platte River basin, covers a 16,000-square-mile area of diverse geology, topography, and climate. This diversity results in contrasting hydrologic characteristics.The South Platte River, the major stream in the area, and most of its tributaries originate in granitic mountains and flow into and through the sedimentary rocks of the Great Plains. Altitudes range from less than 5,000 feet to more than 14,000 feet above sea level. Precipitation in the mountains may exceed 40 inches annually, much of it during the winter, and produces deep snowpacks. Snowmelt during the spring and summer produces most streamflow. Transmountain diversion of water from the streams on the western slope of the mountains also adds to the streamflow. Precipitation in the plains is as little as 10 inches annually. Streams that originate in the plains are ephemeral.Streamflow quality is best in the mountains, where dissolved-solids concentrations are generally small. Concentrations increase in the plains as streams flow through sedimentary basins, and as urbanization and irrigation increase. The quality of some mountain streams is affected by

  8. Effect of ascorbic acid, sodium citrate, sodium bicarbonate, and their combination effect on the binding of 59Fe2+ and 59Fe3+ to plasma membrane of lactating mouse mammary gland.

    Science.gov (United States)

    Moutafchiev, D A; Sirakov, L M; Ovcharoff, V A

    1990-12-01

    Isolated plasma membranes of lactating mouse mammary gland were treated with different concentrations of ascorbate, sodium citrate, sodium bicarbonate, and combinations of them (from 16 x 10(-10) to 4 x 10(-6) moles/L) and studied for the binding of 59Fe2+ and 59Fe3+ at pH 7.4. The results show that the Fe3+ form of iron is under a greater influence of anions used in these experiments. The Fe2+ form of iron is weakly bounded and affected. It is suggested that the form with a greater positive electric charge is more effectively bound to the receptors in plasma membranes.

  9. Action of a specific iron chelate for the metabolism of iron-59 in subjects affected with thalassemia major. [Desferal

    Energy Technology Data Exchange (ETDEWEB)

    Clemente, G.F.; Ingrao, G.; Bianco, I.; Lerone, M.

    1982-01-01

    Some subjects, ranging in age from 6 to 12 years, suffering with thalassemia major, which causes a continuous iron overload in most organs and tissues of the patients, were treated with Desferal, an iron-chelating agent. Supposing that iron accumulates both in the reticuloendothelial and parenchymatous cells, particularly in liver and myocardium, where its overload is very dangerous, we have tried to identify the exact site of action of Desferal. Therefore the patients were injected with a /sup 59/Fe solution and treated regularly with a chelating therapy with Desferal. Measurements of the /sup 59/Fe body burden were made during a period of about 6 months post injection and measurements of /sup 59/Fe and stable iron in blood, urine, and feces samples during a period of about 1 month post injection.

  10. Flow cytometric analysis of CD55 and CD59 expression on blood cells in paroxysmal nocturnal haemoglobinuria

    Directory of Open Access Journals (Sweden)

    Anna Czyz

    2011-08-01

    Full Text Available PNH is a rare clonal disorder of hematopoietic stem cells, therefore all blood cells lineages are involved. The main feature is an increased sensitivity of erythrocytes to complement-mediated cell lysis due to deficiency of membrane-bound GPI (glycosylphosphatidylinositol-anchored proteins which normally function as inhibitors of reactive hemolysis. In the present study, we performed flow cytometric analysis using monoclonal antibodies against CD55 and CD59 for the detection of PNH-type clone in the blood of 50 patients (28 females and 22 males, age range 7-67 yrs. In one patient only we found a large population (95% of granulocytes with decreased expression of both CD55 and CD59 molecules (type I PNH and in two others with partial loss of CD55 expression (type II PNH. The expression was determined chiefly on granulocytes which in the control group showed reliable and high expression of CD55 and CD59.

  11. Analysis of metallographic structure and hardness of aluminum alloy 3L59 from the structure of vulcanization equipment

    Directory of Open Access Journals (Sweden)

    P. Armăşoiu

    2015-07-01

    Full Text Available The use of aluminum and special alloys of aluminum in the construction of large installations as is the case of vulcanization equipment, cause a substantial reduction in their weight, while increasing the useful capacity used in the joint process. Metallic structure of vulcanization equipment is made of aluminum alloy 3L59, and after a period of use it was found a deterioration of the quality of joints caused by the modification of the properties of the metallic structure from 3L59. The modification of the properties of the metallic structure is determined by the presence of heat in the vulcanization process and in this regard it has been made an analyze of modifications of metallographic structure and hardness which occur in aluminum alloy 3L59.

  12. Production, purification, sequencing and activity spectra of mutacins D-123.1 and F-59.1

    Directory of Open Access Journals (Sweden)

    LaPointe Gisèle

    2011-04-01

    Full Text Available Abstract Background The increase in bacterial resistance to antibiotics impels the development of new anti-bacterial substances. Mutacins (bacteriocins are small antibacterial peptides produced by Streptococcus mutans showing activity against bacterial pathogens. The objective of the study was to produce and characterise additional mutacins in order to find new useful antibacterial substances. Results Mutacin F-59.1 was produced in liquid media by S. mutans 59.1 while production of mutacin D-123.1 by S. mutans 123.1 was obtained in semi-solid media. Mutacins were purified by hydrophobic chromatography. The amino acid sequences of the mutacins were obtained by Edman degradation and their molecular mass was determined by mass spectrometry. Mutacin F-59.1 consists of 25 amino acids, containing the YGNGV consensus sequence of pediocin-like bacteriocins with a molecular mass calculated at 2719 Da. Mutacin D-123.1 has an identical molecular mass (2364 Da with the same first 9 amino acids as mutacin I. Mutacins D-123.1 and F-59.1 have wide activity spectra inhibiting human and food-borne pathogens. The lantibiotic mutacin D-123.1 possesses a broader activity spectrum than mutacin F-59.1 against the bacterial strains tested. Conclusion Mutacin F-59.1 is the first pediocin-like bacteriocin identified and characterised that is produced by Streptococcus mutans. Mutacin D-123.1 appears to be identical to mutacin I previously identified in different strains of S. mutans.

  13. Adrenal computed tomography and NP-59 usefulness for diagnosing aldosterone-producing adenomas and idiopathic hyperaldosteronism in primary hyperaldosteronism

    Directory of Open Access Journals (Sweden)

    Ting-Po Lin

    2016-12-01

    Conclusion: For the subtyping of primary aldosteronism, the imaging modality of adrenal CT alone or the combination of adrenal CT and NP-59 adrenal scan has a high positive predictive value for APAs. We suggest that all patients undergo an adrenal CT as their initial study, after confirming the diagnosis of primary aldosteronism, and to use NP-59 when adrenal CT findings are atypical or inconclusive. Lateralization by this modality prior to adrenalectomy can reduce unnecessarily invasive examinations such as adrenal venous sampling and also provide excellent treatment outcomes.

  14. 23 CFR 661.59 - What should be done with a deficient BIA owned IRR bridge if the Indian Tribe does not support...

    Science.gov (United States)

    2010-04-01

    ... bridge if the Indian Tribe does not support the project? 661.59 Section 661.59 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.59 What should be done with a deficient BIA owned IRR bridge if the Indian Tribe does not...

  15. Severe imported malaria in an intensive care unit: a review of 59 cases

    Directory of Open Access Journals (Sweden)

    Santos Lurdes C

    2012-03-01

    Full Text Available Abstract Background In view of the close relationship of Portugal with African countries, particularly former Portuguese colonies, the diagnosis of malaria is not a rare thing. When a traveller returns ill from endemic areas, malaria should be the number one suspect. World Health Organization treatment guidelines recommend that adults with severe malaria should be admitted to an intensive care unit (ICU. Methods Severe cases of malaria in patients admitted to an ICU were reviewed retrospectively (1990-2011 and identification of variables associated with in-ICU mortality performed. Malaria prediction score (MPS, malaria score for adults (MSA, simplified acute physiology score (SAPSII and a score based on WHO's malaria severe criteria were applied. Statistical analysis was performed using StataV12. Results Fifty nine patients were included in the study, all but three were adults; 47 (79,6% were male; parasitaemia on admission, quantified in 48/59 (81.3% patients, was equal or greater than 2% in 47 of them (97.9%; the most common complications were thrombocytopaenia in 54 (91.5% patients, associated with disseminated intravascular coagulation (DIC in seven (11.8%, renal failure in 31 (52.5% patients, 18 of which (30.5% oliguric, shock in 29 (49.1% patients, liver dysfunction in 27 (45.7% patients, acidaemia in 23 (38.9% patients, cerebral dysfunction in 22 (37.2% patients, 11 of whom with unrousable coma, pulmonary oedema/ARDS in 22 (37.2% patients, hypoglycaemia in 18 (30.5% patients; 29 (49.1% patients presented five or more dysfunctions. The case fatality rate was 15.2%. Comparing the four scores, the SAPS II and the WHO score were the most sensitive to death prediction. In the univariate analysis, death was associated with the SAPS II score, cerebral malaria, acute renal and respiratory failure, DIC, spontaneous bleeding, acidosis and hypoglycaemia. Age, partial immunity to malaria, delay in malaria diagnosis and the level of parasitaemia were

  16. Search for a diffuse flux of astrophysical muon neutrinos with the IceCube 59-string configuration

    DEFF Research Database (Denmark)

    Aartsen, M.G.; Abbasi, R.; Ackermann, M.

    2014-01-01

    A search for high-energy neutrinos was performed using data collected by the IceCube Neutrino Observatory from May 2009 to May 2010, when the array was running in its 59-string configuration. The data sample was optimized to contain muon neutrino induced events with a background contamination...

  17. On-Ball Doping of Fullerenes : The Electronic Structure of C59N Dimers from Experiment and Theory

    NARCIS (Netherlands)

    Pichler, Thomas; Knupfer, Martin; Golden, Mark S.; Haffner, Stefan; Friedlein, Rainer; Fink, Jörg; Andreoni, Wanda; Curioni, Alessandro; Keshavarz-K, Majid; Bellavia-Lund, Cheryl; Sastre, Angela; Hummelen, Jan-Cornelis; Wudl, Fred

    1997-01-01

    We present the first studies of the electronic structure of the heterofullerene (C59N)2 using electron energy-loss spectroscopy in transmission, photoemission spectroscopy, and density functional theory calculations. Both the C 1s excitation spectra and valence band photoemission show negligible

  18. 38 CFR 59.40 - Maximum number of nursing home care and domiciliary care beds for veterans by State.

    Science.gov (United States)

    2010-07-01

    ... projection of demand for nursing home and domiciliary care by veterans who at such time are 65 years of age... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Maximum number of nursing... ACQUISITION OF STATE HOMES § 59.40 Maximum number of nursing home care and domiciliary care beds for veterans...

  19. 49 CFR 551.59 - May the same individual sign both the Designation by Foreign Manufacturer and Acceptance by Agent?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false May the same individual sign both the Designation... Contents of Designation § 551.59 May the same individual sign both the Designation by Foreign Manufacturer... explanatory letter at the same time it receives the designation, the agency will deem the designation...

  20. Coronavirus MHV-A59 infects the lung and causes severe pneumonia in C57BL/6 mice.

    Science.gov (United States)

    Yang, Zhangsheng; Du, Jun; Chen, Gang; Zhao, Jie; Yang, Xuanming; Su, Lishan; Cheng, Genhong; Tang, Hong

    2014-12-01

    It remains challenging to develop animal models of lung infection and severe pneumonia by severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome cornavirus (MERS-CoV) without high level of containment. This inevitably hinders understanding of virushost interaction and development of appropriate countermeasures. Here we report that intranasal inoculation of sublethal doses of murine coronavirus mouse hepatitis virus A-59 (MHV-A59), a hepatic and neuronal tropic coronavirus, can induce acute pneumonia and severe lung injuries in C57BL/6 mice. Inflammatory leukocyte infiltrations, hemorrhages and fibrosis of alveolar walls can be observed 2-11 days after MHV-A59 infection. This pathological manifestation is associated with dramatical elevation of tissue IP-10 and IFN-γ and moderate increase of TNF-α and IL-1β, but inability of anti-viral type I interferon response. These results suggest that intranasal infection of MHV-A59 would serve as a surrogate mouse model of acute respiratory distress syndrome by SARS-CoV and MERS-CoV infections.

  1. Exposure to famine during gestation, size at birth, and blood pressure at age 59 y: Evidence from the dutch famine

    NARCIS (Netherlands)

    Stein, A.D.; Zybert, P.A.; Pal-de Bruin, K.M. van der; Lumey, L.H.

    2006-01-01

    We compared blood pressure of individuals (mean age 59 y) born in western Holland between January 1945 and March 1946 (mothers exposed to the Dutch Famine before or during gestation; n = 359) to blood pressure of unexposed individuals born before or conceived after the famine (n = 299) or same-sex

  2. 42 CFR 59.7 - What criteria will the Department of Health and Human Services use to decide which family...

    Science.gov (United States)

    2010-10-01

    ... Department of Health and Human Services use to decide which family planning services projects to fund and in... 42 Public Health 1 2010-10-01 2010-10-01 false What criteria will the Department of Health and Human Services use to decide which family planning services projects to fund and in what amount? 59.7...

  3. Safety and immunogenicity of an MF59™-adjuvanted subunit influenza vaccine in elderly Chinese subjects

    Directory of Open Access Journals (Sweden)

    Pellegrini Michele

    2008-02-01

    Full Text Available Abstract Background The safety and immunogenicity of an MF59™-adjuvanted subunit influenza vaccine (Sub/MF59™; FLUAD®, Novartis Vaccines was evaluated among elderly Chinese subjects (≥ 60 years of age. After a preliminary Phase I, open-label study (n = 25 to assess safety 1–14 days post-vaccination, a comparative observer-blind, randomised, controlled clinical trial (n = 600 was performed to assess safety and immunogenicity versus a non-adjuvanted subunit influenza vaccine (Subunit; Agrippal®, Novartis Vaccines. Subjects were randomised (2:1 to receive Sub/MF59™ or Subunit. Results Both vaccines were well tolerated, with no vaccine-related serious adverse events reported during the Phase I trial. During the observer-blind study, local and systemic reactions were generally similar for both vaccines 1–22 days post-vaccination; however, injection-site induration was more frequent among the Subunit group (P Conclusion MF59™-adjuvanted subunit influenza vaccine is well tolerated by elderly Chinese subjects and induces a higher level of immunogenicity than a non-adjuvanted subunit influenza vaccine in this population that is at high risk of influenza-related complications. Clinical trial registry http://www.clinicaltrials.gov, NCT00310648

  4. 2017-12-10T00:59:52Z https://www.ajol.info/index.php/index/oai oai ...

    African Journals Online (AJOL)

    article/48192 2017-12-10T00:59:52Z ict:ART An Appraisal Of Public Branch ... hold ings fall short of the required volumes to serve the population of the areas surveyed, though they hold a vibrant collectionof periodicals, especially newspapers.

  5. 31 CFR 5.9 - When will Treasury entities transfer a Treasury debt to the Treasury Department's Financial...

    Science.gov (United States)

    2010-07-01

    ... a Treasury debt to the Treasury Department's Financial Management Service for collection? 5.9... Treasury Department's Financial Management Service for collection? (a) Treasury entities will transfer any eligible debt that is more than 180 days delinquent to the Financial Management Service for debt collection...

  6. 2018-02-14T07:59:32Z https://www.ajol.info/index.php/index/oai oai ...

    African Journals Online (AJOL)

    article/50765 2018-02-14T07:59:32Z samj:ART Mental health service use among South Africans for mood, anxiety and substance ... Age, income, education and marital status were not significantly associated with mental health service use.

  7. DETECTION AND FOLLOW UP OF PNH CLONE BY MEASURING CD55 AND CD59 EXPRESSION ON NEUTROPHILS

    Directory of Open Access Journals (Sweden)

    Uroš Mlakar

    2004-12-01

    Full Text Available Background. Paroxysmal nocturnal haemoglobinuria (PNH is an acquired clonal haematopoietic stem cell disorder characterised by intravascular haemolysis, bone marrow failure and increased tendency to thrombosis. It is caused by a somatic mutation in the PIG-A gene, which encodes an enzyme essential for the synthesis of glycosylphosphatidylinositol (GPI anchors. The PIG-A mutation results in a clone of blood cells with total or partial deficiency of membrane proteins anchored to the cell surface through GPI anchor. For many years, an increased susceptibility of the PNH red cells to complement lysis in acidified serum (Ham’s test has been essential for diagnosis of the PNH. Current flow cytometric assays for PNH rely on the use of labeled antibodies to detect deficiencies of the specific GPI anchor proteins on blood cells. We evaluated a three-colour flow cytometry method for detection and quantification of CD55/59 negative netrophils.Patients and methods. Nine patients (6 with PNH and 3 with aplastic anaemia who were previously diagnosed as having PNH or aplastic anaemia were evaluated. In the period of three years the patients were serially evaluated for the extent of PNH clone by quantification of CD55/59 negative neutrophils. Three-colour flow cytometry method was used for quantification of the CD55/CD59 negative neutrophils. We used directly conjugated monoclonal antibodies anti-DC15PC5 for identification of neutrophils and anti-CD59-FITC and anti-CD55-PE for the GPI-linked antigens.Results. Patients with haemolytic PNH had > 50% CD59/CD55 negative granulocytes. The proportion of the PNH granulocytes was higher in the patient with frequent and serious haemolytic attacks. Over the period of three years slow growth of the PNH clone was seen in two cases. Two patients with PNH diagnosed 19 years ago and in remission at the time of flow cytometric analysis was devoid of the PNH clone. Three patients with aplastic anaemia (hypoplastic PNH had the

  8. Validation and adaptation of the Modified Transplant Symptom Occurrence and Symptom Distress Scale-59 Items Revised into Turkish.

    Science.gov (United States)

    Ordin, Yaprak S; Karayurt, Ozgül; Cilengiroğlu, Ozgül Vupa

    2013-12-01

    The Modified Transplant Symptom Occurrence and Symptom Distress Scale-59 Items Revised (MTSOSD-59R) is a validated self-reported scale assessing patients' subjective experiences of adverse effects of immunosuppressants. It has been reported that the scale should be adapted and validated before it is used in patients of a different cultural (Brazilian, Dutch, German, French, Hindi, Italian, Spanish, and Swedish) background. To validate and adapt the MTSOSD-59R for use in Turkish transplant recipients. This cross-sectional study was performed between March 2010 and February 2011, and included 180 liver and kidney transplant recipients treated in 2 university hospitals in western Turkey. In addition, 180 healthy control participants were recruited from a community health service. Data were collected by using a demographic and clinical characteristics scale (MTSOSD-59R) and the Beck Depression Inventory. Items were translated in a culturally sensitive way by using forward-backward translation. Content validity was evaluated by using the content validity index. Ridit analysis and descriptive statistics helped to describe symptom experience in our population, and Mann Whitney U testing was used to compare patients versus healthy controls, depressed versus nondepressed patients, and male versus female patients for validity purposes. Split-half reliability analysis was used. The content validity index was perfect (ie, value 1.0); the Turkish translation of the MTSOSD-59R had excellent known group validity. Split-half Spearman Brown corrected reliability coefficient was 0.991 for symptom occurrence and 0.992 for symptom distress. The results suggest that the Turkish scale has appropriate language, content, and construct validity. This scale can now be used to assess the symptom experience related to immunosuppressive therapy in Turkish organ transplant recipients.

  9. Prevalence of anemia in children 6-59 months old in the state of Pernambuco, Brazil Prevalencia de la anemia en niños de 6 a 59 meses en el estado de Pernambuco, Brasil

    Directory of Open Access Journals (Sweden)

    Mônica M. Osório

    2001-08-01

    Full Text Available Objective. To determine the prevalence of anemia in children 6-59 months old in Pernambuco, a state in northeastern Brazil, so as to help guide health and nutrition policies there. Methods. In 1997 a representative sample of 777 young children had their hemoglobin concentration measured. The sampling process was in three stages. First, 18 municipalities were randomly selected to represent the state and its three geographic areas (metropolitan region of Recife, urban interior, and rural interior. Next, using census lists, 45 census sectors were randomly chosen. Finally, 777 children aged 6-59 months old were selected. Blood was collected by venipuncture, and hemoglobin was measured with a portable hemoglobinometer. In the analysis, prevalence was weighted to reflect the census age distribution. Results. The prevalence of anemia among children 6-59 months old was 40.9% for the state as a whole. Prevalence in the metropolitan region of Recife was 39.6%, and it was 35.9% in the urban interior. The rural interior had the highest prevalence, 51.4%. Prevalence was twice as high in children aged 6-23 months as among those 24-59 months old, 61.8% vs. 31.0% (chi² = 77.9, P Objetivos. Determinar la prevalencia de la anemia en niños de 6 a 59 meses en Pernambuco, un estado del nordeste de Brasil, con el fin de ayudar a establecer las políticas de salud y nutrición. Métodos. En 1997 se determinaron las concentraciones de hemoglobina en una muestra representativa de 777 niños. El proceso de muestreo se realizó en tres fases. Primero se seleccionaron aleatoriamente 18 municipios representativos del estado y de sus tres zonas geográficas (la región metropolitana de Recife, el interior urbano y el interior rural. A continuación, utilizando las listas del censo, se seleccionaron aleatoriamente 45 sectores censales. Finalmente, se seleccionaron 777 niños de 6 a 59 meses de edad. La sangre se recogió por punción venosa y la hemoglobina se midió con un

  10. Los excerpta de Beda (De Temporum Ratione 19 y 23 en Ripoll (ACA, Ripoll 59 y Vat. Reg. Lat. 123

    Directory of Open Access Journals (Sweden)

    José Martínez Gázquez

    1996-12-01

    Full Text Available The analysis of texts and glossaries contained in the manuscript ACA Ripoll 59 reveals various compilations of glossaries and «computation» texts, besides Priscian's grammar, which is the most important text in the manuscript. The analysis and identification of the fragments in ACA Ripoll 59 the same as those in Vat. Reg. Lat. 123, which also belongs to the manuscripts found in Ripoll, corresponding to various chapters of Beda, allow us to study the different currents that exerted their cultural influence in the Monastery of Santa Maria de Ripoll. Through the variants established for each of the texts that have been identified, one detects the influence of various families of manuscripts in the composition of these fragments.

  11. Supplemental site inspection for Air Force Plant 59, Johnson City, New York, Volume 2: Appendices A-E

    Energy Technology Data Exchange (ETDEWEB)

    Nashold, B.; Rosenblatt, D.; Tomasko, D. [and others

    1995-08-01

    This summary describes a Supplemental Site Inspection (SSI) conducted by Argonne National Laboratory (ANL) at Air Force Plant 59 (AFP 59) in Johnson City, New York. All required data pertaining to this project were entered by ANL into the Air Force-wide Installation Restoration Program Information System (IRPIMS) computer format and submitted to an appropriate authority. The work was sponsored by the United States Air Force as part of its Installation Restoration Program (IRP). Previous studies had revealed the presence of contaminants at the site and identified several potential contaminant sources. Argonne`s study was conducted to answer questions raised by earlier investigations. This volume consists of appendices A-E, containing field data and data validation.

  12. Complement regulatory proteins (CD46, 55 and 59) expressed on Schwann cells: immune targets in demyelinating neuropathies?

    Science.gov (United States)

    Miyaji, Kazuki; Paul, Friedemann; Shahrizaila, Nortina; Umapathi, Thirugnanam; Yuki, Nobuhiro

    2014-11-15

    Given their localization and important role in regulating complement, complement regulatory proteins may act as target antigens and their antibodies as biomarkers in demyelinating neuropathies. We investigated the binding of autoantibodies to complement regulatory proteins (CD46, 55 and 59) in demyelinating diseases. In 42 acute inflammatory demyelinating polyneuropathy, 23 chronic inflammatory demyelinating polyneuropathy, 13 acute motor axonal neuropathy, 71 multiple sclerosis, and 19 neuromyelitis optica patients as well as 55 healthy controls, we were unable to detect significant titers of antibodies to CD46, CD55 and CD59. These autoantibodies are unlikely to be biomarkers in acute and chronic inflammatory demyelinating polyneuropathies. Copyright © 2014 Elsevier B.V. All rights reserved.

  13. Supplemental site inspection for Air Force Plant 59, Johnson City, New York, Volume 3: Appendices F-Q

    Energy Technology Data Exchange (ETDEWEB)

    Nashold, B.; Rosenblatt, D.; Hau, J. [and others

    1995-08-01

    This summary describes a Supplemental Site Inspection (SSI) conducted by Argonne National Laboratory (ANL) at Air Force Plant 59 (AFP 59) in Johnson City, New York. All required data pertaining to this project were entered by ANL into the Air Force-wide Installation Restoration Program Information System (IRPIMS) computer format and submitted to an appropriate authority. The work was sponsored by the United States Air Force as part of its Installation Restoration Program (IRP). Previous studies had revealed the presence of contaminants at the site and identified several potential contaminant sources. Argonne`s study was conducted to answer questions raised by earlier investigations. This volume consists of appendices F-Q, which contain the analytical data from the site characterization.

  14. Adrenocortical scintigraphy with {sup 131}I-6-beta-iodomethyl-norcholesterol (NP 59) in bilateral adrenocortical carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz Hernandez, G.; Pallares, F.J.C.; Avila y Avalos, C.R. de [Hospital Clinic Universitari de Valencia (Spain). Servei de Medicina Nuclear; Bartual, A.R.; Rodrigo, S.T.; Ampudia-Blasco, F.J. [Hospital Clinic Universitari de Valencia (Spain). Servei d`Endocrinologia

    1998-06-01

    A case of a 49-year-old man suffering from bilateral adrenocortical carcinoma with local and secondary rapid progression is reported. The results of adrenocortical scintigraphy (NP 59) and histological findings allowed the diagnosis. This case report and a literature review showed the importance of using adrenocortical scintigraphy as a complementary imaging procedure of CT or MR images. (orig.) [Deutsch] Es wird ueber einen 49jaehrigen Mann berichtet, der an einem beidseitigen Nebennierenrinden-Karzinom mit schneller lokaler und sekundaerer Progression leidet. Die Ergebnisse der Nebennierenrinden-Szintigraphie (NP 59) und Histologie ermoeglichten die Diagnose: Dieser Fallbericht und ein Literaturueberblick zeigen die Bedeutung der Nebennierenrinden-Szintigraphie als ein zusaetzliches bildgebendes Verfahren neben CT und NMR. (orig.)

  15. Correction to: Cyberpsychol Behav Soc Netw 2015;18(2);59-71 DOI: 10.1089/cyber.2014.0343.

    Science.gov (United States)

    2015-11-01

    In the February 2015 issue of Cyberpsychology, Behavior, and Social Networking (vol. 18, no. 2, pp. 59–71), the article "Association Between Pornography Use and Sexual Risk Behaviors in Adult Consumers: A Systematic Review," by Emily L. Harkness et al., the second author's name was displayed as "Barbara M. Mullan;" however, the middle initial is incorrect. The authors wish to apologize for the error and Dr. Mullan would like to be cited without a middle initial simply as "B Mullan."

  16. [Construction of MHV-A59 damp-heat mouse model and analysis of the relevant indices].

    Science.gov (United States)

    Tang, Zhao-hui; Su, Li-xian; Li, Hua-feng; Guo, Jin-qiang; Luo, Bing-de; Lin, Pei-zheng

    2010-11-01

    To explore the impact of inflammation, water metabolism and immune function on the establishment of a mouse model of damp-heat syndrome with MHV-A59 infection. Twenty-four mice were randomly divided into control group, virus group, damp-heat group and model group. The peripheral blood CD4(+) and CD8(+) lymphocytes were detected by flow cytometry, and the serum levels of IFN-γ and IL-4 were assayed by ELISA. The expressions of NF-κB and AQP4 in the liver and stomach were determined using immunohistochemistry. The expression of NF-κB and CD4(+)/CD8(+) ratio in the virus and model groups were significantly higher than those in the damp-heat and control groups, while the expression of AQP4 was significantly higher in the model and damp-heat groups than in the other groups. Compared with the control group, the model group showed a significantly higher ratio of IFN-γ/IL-4. MHV-A59 virus is the main cause of elevated NF-κB expression and CD4(+)/CD8(+)/ ratio, while damp-heat syndrome is responsible for increased AQP4 expression, and their synergistic effect results in increased IFN-γ/IL-4 ratio. The mouse model established using MHV-A59 virus and the damp-heat factors can mimic damp-heat syndrome described in traditional Chinese medicine theory.

  17. AMRI-59 has a role of radiosensitizer via enhancement of γ-ionizing radiation-induced apoptotic cell death

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Wan Gi; Cho, Jeong Hyun; Kim, Ju Yeon; Hwang, Sang Gu; Um, Hong Duck; Park, Jong Kuk [KAERI, Daejeon (Korea, Republic of)

    2016-05-15

    Recent in vitro studies have suggested that may increase the invasiveness of some cancer cells (e.g., glioma, hepatocellular carcinoma, and pancreatic cancer cells) by stimulating several intracellular signaling pathways and in vivo studies have found that radiotherapy of primary tumor sites may promote metastasis. Thus, in addition to having therapeutic effects, IR might promote the malignant traits of surviving cancer cells. The existing efforts to develop radiosensitizing agents have focused on overcoming radioresistance and reducing damage to normal tissues. Recently, concepts of personalized- or precision medicine are developed due to advancement of mega data technique, which provide new targets to develop new anti-cancer drugs. In this study, we sought to identify the radiosensitizer effect of AMRI-59 in vitro and in vivo., which is recently developed specific inhibitor of peroxiredoxin (Prx) I. AMRI-59 enhanced radiation-induced cell death and its mean calculated dose enhancement ratio was 1.26. We also found combination of AMRI-59 and IR In a xenograft assay, the combined PHCM and radiation group showed 14.3 days of growth delay versus the control in terms of tumor growth. The enhancement factor of this combined treatment was determined to be 2.03.

  18. BCG Increased Membrane Expression of TRIM59 Through the TLR2/ TLR4/IRF5 Pathway in RAW264.7 Macrophages.

    Science.gov (United States)

    Jin, Zheng; Tian, Yuan; Yan, Dongmei; Li, Dong; Zhu, Xun

    2017-01-01

    In our previous study, we showed that Bacillus Calmette-Guerin (BCG)- activated macrophages have the ability to directly kill tumor cells. One of the main properties of these macrophages is the high expression of tripartite motif family protein 59 (TRIM59). This study was conducted to investigate the mechanism of BCG-induced TRIM59 expression on macrophages and to identify the subcellular localization of TRIM59. TRIM59 expression and TNF-α secretion were compared in RAW264.7 macrophage cells that were stimulated using BCG with or without Toll-like receptor 2/4 (TLR2/4)-neutralizing antibodies. Next, small interfering RNA (siRNA) was used to down-regulated interferon regulatory factor 5 (IRF5) gene expression in RAW264.7 cells. Transfected cells were stimulated with BCG, after which TRIM59 expression and TNF-α secretion were evaluated in cells pre-treated with siRNA or scramble control. After treatments, supernatants were co-cultured with MCA207, and cell viabilities were determined. Moreover, BCG-stimulated RAW264.7 cells were stained for TRIM59 and F4/80 expression. In this study, we showed that TRIM59 was expressed on the membrane of RAW264.7 cells. After blocking TLR2/4, treatment with BCG failed to induce the expression of TRIM59, IRF5, and TNF-α on RAW264.7 cells. In addition, down-regulation of IRF5 inhibited TRIM59 and TNF-α expression. Our study showed that TRIM59 is a membrane protein, and that BCG treatment upregulated TRIM59 expression on macrophages via TLR2/4 and IRF5 pathways. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  19. Amplificación del gen CAP59 en Cryptococcus neoformans y Cryptococcus gattii directamente a partir de una suspensión de levaduras CAP59 gene amplification in Cryptococcus neoformans and Cryptococcus gattii directly from a yeast suspension

    Directory of Open Access Journals (Sweden)

    N. Siachoque

    2010-06-01

    Full Text Available Cryptococcus es una levadura capsulada de la clase Basidiomycetes y es el agente etiológico de la criptococosis. La criptococosis es una de las infecciones oportunistas más comunes en pacientes inmunosuprimidos, aunque puede afectar a individuos inmunocompetentes. En los últimos años, la identificación de especies fúngicas de importancia médica se ha logrado gracias a la amplificación de determinadas regiones del ADN o de genes fúngicos mediante la reacción en cadena de la polimerasa (PCR. El gen CAP59 está implicado en la síntesis de la cápsula en Cryptococcus neoformans y Cryptococcus gattii, y es de utilidad en la identificación molecular de sus serotipos. En este trabajo utilizamos aislamientos de distintos serotipos provenientes de una colección de cultivos y de C. neoformans recuperados de pacientes con criptococosis. La amplificación del gen CAP59 se realizó a partir de suspensiones estandarizadas de levaduras de los diferentes aislamientos de Cryptococcus, las que actuaron como molde. Este procedimiento fue rápido, sencillo y económico y no requirió ningún paso previo a la PCR, lo que puede facilitar en forma considerable la realización de estudios taxonómicos en los laboratorios que disponen de herramientas de biología molecular.Cryptococcus is an encapsulated yeast of class Basidiomycetes, etiologic agent of cryptococcosis. Cryptococcosis is one of the most common opportunistic infections in immunosuppressed patients, although it can affect immunocompetent individuals. In recent years, the identification of medically important fungal species has been achieved through the amplification of specific regions or genes of fungal DNA by polymerase chain reaction (PCR. The CAP59 gene is involved in the synthesis of the capsule in Cryptococcus neoformans and Cryptococcus gattii, and is useful in the molecular identification of serotypes. In this research, we use yeasts of different serotypes from collection strains and C

  20. Assessment of Alveolar Bone Status in Middle Aged Chinese (40-59 Years) with Chronic Periodontitis--Using CBCT.

    Science.gov (United States)

    Zhao, Haijiao; Li, Chen; Lin, Li; Pan, Yaping; Wang, Hongyan; Zhao, Jian; Tan, Lisi; Pan, Chunling; Song, Jia; Zhang, Dongmei

    2015-01-01

    This study used con-beam computed tomography (CBCT) to investigate the prevalence and severity of alveolar bone loss in middle-aged (40-59 years) Chinese with chronic periodontitis. The study group comprised 145 dentate individuals aged 40 to 59 years residing in China who suffered from chronic periodontitis. CBCT and the application of NNT software were used to examine the level and location of alveolar bone loss. The study revealed that 40-59 year old patients with chronic periodontitis had severe bone loss. At 5,286 sites (34.7%), alveolar bone loss was mild; severe alveolar bone loss was found at 5,978 sites (39.2%). A comparison of bone loss in different jaws revealed that the area with the highest degree of bone loss was on the lingual side of the maxillary molar (56.3 ± 7.2%), and that the area with the lowest degree was primarily on the lingual side of the mandibular canine (27.5 ± 6.3%). There was a lower degree of alveolar bone loss in males than females. Differences were observed when comparing the incidence of bone loss between males and females (P smoking in both genders may affect the level of bone loss. Male smokers experienced a greater degree of bone loss (41.67 ± 5.76%) than male non-smokers (32.95 ± 4.31%). A 42.23 ± 6.34% bone loss was found in menopausal females versus 31.35 ± 3.62% in non-menopausal females. The study revealed that different sites and teeth exhibited a diverse degree of bone loss. In middle-aged patients with chronic periodontitis, the highest degrees of bone loss in the incisors, premolars, and molars were on the lingual side, mesial side and lingual side, respectively. Menopause in females and smoking may affect the level of bone loss.

  1. [Fruit and vegetables intake among the Chinese migrant population aged 18 to 59 years old in 2012].

    Science.gov (United States)

    Zhang, Mei; Wang, Linhong; Deng, Qian; Zhao, Yinjun; Huang, Zhengjing; Li, Yichong; Jiang, Yong; Wang, Limin

    2014-11-01

    To describe the intake of fruit and vegetables among employed migrant population aged 18 to 59 year-olds in China. Data from the Migrant Population Survey related to China Chronic Disease and Risk Factor Surveillance that conducted in 170 counties/districts in 31 provinces, 2012, was used. Information on non-communicable diseases and related risk factors among migrant population were collected through face-to-face questionnaire interview, physical measurement and lab tests. A total of 48 704 subjects aged 18 to 59 years old were included in our study. Sample was standardized by age and sex. Information on average daily fruit and vegetables intake, prevalence of low fruit and vegetables intake, grouped by sex, age, industries, and education level were analyzed. The average daily intakes of vegetables and fruits were 353.7 (95%CI:351.3-356.2) g and 125.1 (95%CI:123.4-126.9) g respectively, among the employed migrant population aged 18-59 years old in China. Prevalence of low fruit and vegetables intake was 44.1% (95% CI:43.5%-44.6% ) among employed migrant population, 46.2% (95% CI: 45.5%-47.0%)for males and 41.2% (95% CI:40.3%-42.0%)for females (χ(2) = 82.19, P fruit and vegetables intake was the highest among people working in accommodation and restaurants (46.2%, 95%CI:45.0%-47.3%) while the lowest seen among those working in social services (42.5%, 95%CI:41.4%-43.7%,χ(2) = 15.81, P fruit and vegetables intake showed a decrease along with the increase of education levels (χ(2) = 22.29, P fruit and vegetables intake. Being male and with low education level were risk factors linked with the higher prevalence of low fruit and vegetables intake.

  2. Prevalence and associated factors of seasonal influenza vaccination among 24- to 59-month-old children in Hong Kong.

    Science.gov (United States)

    Wu, Anise M S; Lau, Joseph T F; Ma, Yee Ling; Lau, Mason M C

    2015-07-09

    Influenza results in severe complications among 24- to 59-month-old children, who are recommended by the WHO to take up influenza vaccination (IV) annually. Health promotion is warranted. Yet, there is a dearth of studies on IV prevalence and associated factors in this age group. A random population-based telephone survey interviewed 540 parents of Chinese children aged 24-59 months in Hong Kong during March through June, 2011. Constructs of the Health Belief Model (HBM) and subjective norm formed basis for assessing parental perceptions on influenza and IV. For data analysis, adjusted, and stepwise multiple logistic regression models were fit. The prevalence of having taken up at least one dose and two doses of IV among children aged 24-59 months was 58.9 and 42.4%, respectively. Significant associated factors included family members' IV experience (ORu=5.37, 95% CI: 3.48, 8.29), variables related to the HBM constructs (except perceived severity) [perceived susceptibility of seasonal influenza (ORu=2.03, 95% CI: 1.39, 2.95), perceived benefits of IV (ORu=3.11, 95% CI: 2.05, 4.71), perceived barriers (ORu=0.49, 95% CI: 0.25, 0.96) of IV, and cue to action (ORu=4.79, 95% CI: 2.87, 7.99)], supportive subjective norm (ORu=4.26, 95% CI: 2.91, 6.25), and level of fear felt during the H1N1 pandemic (ORu=1.97, 95% CI: 1.01, 3.87). Adjusted for the child's age, the same significant factors were found. Exposure to related media messages was statistically non-significant. The reported IV prevalence was higher than that of 24- to 59-month-old children reported in other studies. There is room for improvement through health promotion, which should modify parental cognitions related to HBM (except perceived severity and self-efficacy) and involve family members to create subjective norm. Media campaigns may be inadequate for promotion of IV; use of the setting approach may be considered. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. 10-GHz 1.59-μm quantum dash passively mode-locked two-section lasers

    DEFF Research Database (Denmark)

    Dontabactouny, Madhoussoudhana; Rosenberg, C.; Semenova, Elizaveta

    2010-01-01

    This paper reports the fabrication and the characterisation of a 10 GHz two-section passively mode-locked quantum dash laser emitting at 1.59 μm. The potential of the device's mode-locking is investigated through an analytical model taking into account both the material parameters and the laser...... geometry. Results show that the combination of a small absorbing section coupled to a high absorption coefficient can lead to an efficient mode-locking. Characterisation shows mode-locking operation though output pulses are found to be strongly chirped. Noise measurements demonstrate that the single side...

  4. Survival after free falls of 59 metres into water from the Sydney Harbour Bridge, 1930-1982.

    Science.gov (United States)

    Harvey, P M; Solomons, B J

    1983-05-28

    Between 1930 and 1982, 92 persons fell from the Sydney Harbour Bridge into the water, 59 metres below. The major problem among survivors was pulmonary trauma, often with severe respiratory failure. The position of impact influenced survival, the feet-first vertical position being the most favourable. Mortality rate from the fall was 85%. Rapid clinical assessment of victims, especially with reference to pulmonary injury, and prompt institution of ventilatory support, where required, may reverse respiratory failure. Intra-abdominal injuries, spinal column or central nervous system involvement and peripheral fractures should all be suspected.

  5. Regional distribution and aggregation analysis of risk factors for cardiovascular disease among active pilots aged 40-59 years

    Directory of Open Access Journals (Sweden)

    Hong-yan YU

    2016-03-01

    Full Text Available Objective  To analyze the regional distribution and aggregation of risk factors for cardiovascular disease (CVD among active China civil aviation pilots aged 40–59 years. Methods  In 2011, 831 active pilots aged 40–59 years in Northern, Eastern and Southern China were investigated for risk factors of CVD. The regional distribution and aggregation of risk factors were analyzed. Results  The mean hemoglobin A1c (HbA1c, mean total cholesterol (TC and age standardized prevalence rate of high TC in Northern China (5.7%±0.5%, 5.6±1.1mmol/L and 23.6%, respectively were significantly higher than in Eastern and Southern China. High density lipoprotein cholesterol (HDL-C, 1ow density lipoprotein cholesterol (LDL-C and systolic blood pressure (SBP were controlled poorer (1.1±0.2mmol/L, 3.6±0.7mmol/L and 125.7±9.4mmHg, respectively in pilots from Eastern China, and their age standardized prevalence rates of low HDL -C and high LDL -C were 37.9% and 24.6%, respectively, which was obviously higher than that in pilots from other two regions. The mean fast plasma glucose (FPG, 5.5±0.5mmol/L was significantly higher in pilots from Southern China than that in pilots from the other two regions. There was significant difference of 1 and 2 categories of risk factors for CVD among the three regions, and among 1, 2 and ≥3 kinds of CVD risk factors, combination of overweight and obesity, low HDL-C+ overweight and obesity, and high TG+ low HDL-C+ overweight and obesity ranked highest. Conclusions  The regional distribution and aggregation of risk factors for CVD among active pilots aged 40–59 years old are significantly different. Prevention and control measures should be different among these three regions. Weight control is imperative for active pilots aged 40–59 years old. DOI: 10.11855/j.issn.0577-7402.2016.02.16

  6. Determinants of anemia among 6-59 months aged children in Bangladesh: evidence from nationally representative data.

    Science.gov (United States)

    Khan, Jahidur Rahman; Awan, Nabil; Misu, Farjana

    2016-01-11

    Anemia is a global public health problem but the burden of anemia is disproportionately borne among children in developing countries. Anemia in early stages of life has serious consequences on the growth and development of the children. We examine the prevalence of anemia, possible association between anemia and different socio-economic, demographic, health and other factors among children with ages from 6 to 59 months from the nationally representative 2011 Bangladesh Demographic and Health Survey (BDHS). Data on hemoglobin (Hb) concentration among the children aged 6-59 months from the most recent BDHS (2011) were used. This nationally representative survey allowed a multistage stratified cluster sampling design and provided data on a wide range of indicators such as fertility, mortality, women and child health, nutrition and other background characteristics. Anemia status was determined using hemoglobin level (anemia along with 95 % confidence intervals were provided. We also examined the distribution of weighted anemia prevalence across different groups and performed logistic regression to assess the association of anemia with different factors. A total of 2171 children aged 6-59 months were identified for this analysis, with weighted prevalence of anemia being 51.9 % overall- 47.4 % in urban and 53.1 % in rural regions. Results of a multivariable logistic regression analysis showed that, children below 24 months of age (odds ratio, [OR] 3.01; 95 % confidence interval [CI] 2.38-3.81), and those from an anemic mother (OR 1.80; 95 % CI 1.49-2.18) were at higher risk of anemia. Childhood anemia was significantly associated with chronic malnutrition of child, source of drinking water, household wealth and geographical location (defined by division). A high prevalence of anemia among 6-59 months aged children was observed in Bangladesh. Given the negative impact of anemia on the development of children in future, there is an urgent need for effective and

  7. Scandium doped Strontium Titanate Ceramics: Structure, Microstructure, and Dielectric Properties

    Directory of Open Access Journals (Sweden)

    Tkach, Alexander

    2008-08-01

    Full Text Available Sc-doped strontium titanate (ST ceramics were synthesised by solid state reaction, according to the composition Sr1-1.5xScxTiO3 with x = 0-0.01. Structural properties and microstructure development was examined by XRD and SEM. The dielectric properties were evaluated as a function of the temperature and frequency in the radio frequency range. Lattice parameter, density and grain size, were found to decrease slightly with increasing Sc content. The dielectric permittivity and losses decrease also. Sc-doping has only a weak effect on the quantum paraelectric behaviour of ST and no dielectric anomaly was observed, what is probably related to the limited solubility of Sc on the Sr site of the perovskite lattice of ST.

    Se sintetizaron materiales cerámicos de titanato de estroncio dopado con escandio mediante reacción en estado sólido De acuerdo a la composición Sr1-1.5xScxTiO3 con x= 0-0.1. Las propiedades estructurales y el desarrollo microestructural se estudiaron mediante XRD y SEM. La propiedades dieléctricas se estudiaron como función de la temperatura y de la frecuencia en el rango de la frecuencias de radio. Se observó que los parámetros de red, la densidad y el tamaño del grano disminuyen ligeramente con el contenido en Sc. La permitividad dieléctrica y las perdidas también disminuyen. El dopado con Sc tiene un efecto muy ligero sobre el comportamiento paraeléctrico cuántico del titanato de estroncio y no se observó anomalías dioeléctricas , lo que está probablemente relacionado con la baja solubilidad del Sc en posiciones del Sr en la estructura tipo perovskita del titanato de estroncio.

  8. Phenoxyl radical complexes of gallium, scandium, iron and manganese.

    Science.gov (United States)

    Adam, B; Bill, E; Bothe, E; Goerdt, B; Haselhorst, G; Hildenbrand, K; Sokolowski, A; Steenken, S; Weyhermüller, T; Wieghardt, K

    1997-02-01

    The hexadentate macrocyclic ligands 1,4,7-tris(3,5-dimethyl-2-hydroxybenzyl)-1,4,7-triazacyclononane (L CH 3H3 ), 1,4,7-tris(3,5-di-tert-butyl-2-hydroxybenzyl)-1,4,7-triazacyclononane (L(Bu) H3 ) and 1,4,7-tris(3-tert-butyl-5-methoxy-2-hydroxybenzyl)-1,4,7-triazacyclononane (L OCH 3-H3 ) form very stable octahedral neutral complexes LM(III) with trivalent (or tetravalent) metal ions (Ga(III) , Sc(III) , Fe(III) , Mn(III) , Mn(IV) ). The following complexes have been synthesized: [L(Bu) M], where M = Ga (1), Sc (2), Fe (3); [L(Bu) Mn(IV) ]PF6 (4'); [L OCH 3M], where M = Ga (1 a), Sc (2 a), Fe (3 a); [L OCH 3Mn(IV) ]PF6 (4 a'); [L CH 3M], where M = Sc (2 b), Fe (3 b), Mn(III) (4 b); [L CH 3Mn(IV) ]2 (ClO4 )3 (H3 O)(H2 O)3 (4 b'). An electrochemical study has shown that complexes 1, 2, 3, 1 a, 2 a and 3 a each display three reversible, ligand-centred, one-electron oxidation steps. The salts [L OCH 3Fe(III) ]ClO4 and [L OCH 3Ga(III) ]ClO4 , have been isolated as stable crystalline materials. Electronic and EPR spectra prove that these oxidations produce species containing one, two or three coordinated phenoxyl radicals. The Mössbauer spectra of 3 a and [3 a](+) show conclusively that both compounds contain high-spin iron(III) central ions. Temperature-dependent magnetic susceptibility measurements reveal that 3 a has an S = 5/2 and [3a](+) an S = 2 ground state. The latter is attained through intramolecular antiferromagnetic exchange coupling between a high-spin iron(III) (S1 = 5/2) and a phenoxyl radical (S2 = 1/2) (H = - 2JS1 S2 ; J = - 80 cm(-1) ). The manganese complexes undergo metal- and ligand-centred redox processes, which were elucidated by spectroelectrochemistry; a phenoxyl radical Mn(IV) complex [Mn(IV) L OCH 3](2+) is accessible. Copyright © 1997 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Atomic layer deposition of scandium-based oxides

    Energy Technology Data Exchange (ETDEWEB)

    Nyns, Laura; Lisoni, Judit G.; Bosch, Geert van den; Elshocht, Sven van; Houdt, Jan van [IMEC, Leuven (Belgium)

    2014-02-15

    Gd{sub x}Sc{sub 2-x}O{sub 3} and Al{sub x}Sc{sub 2-x}O{sub 3} have been investigated as potential high-k intergate dielectric (IGD) in planar NAND flash technology, such as hybrid floating gate (HFG). We have examined the atomic layer deposition (ALD) of Sc{sub 2}O{sub 3}, Gd{sub x}Sc{sub 2-x}O{sub 3}, and Al{sub x}Sc{sub 2-x}O{sub 3} on Si using Sc(MeCp){sub 3}, Gd({sup i}PrCp){sub 3}, TMA, and H{sub 2}O as precursors. The composition of Gd{sub x}Sc{sub 2-x}O{sub 3} and Al{sub x}Sc{sub 2-x}O{sub 3} ranged from 4% to 76% Gd and from 7% to 66% Al, respectively. All compositions show linear growth behavior. While pure Sc{sub 2}O{sub 3} is crystalline as-deposited, the layer becomes amorphous once ∝20% of Al is added. The (222) reflection of the cubic phase is also seen for Gd{sub x}Sc{sub 2-x}O{sub 3} with less than 9% Gd. The bandgap of as-deposited Gd{sub x}Sc{sub 2-x}O{sub 3} decreases with increasing Gd content while the opposite trend is observed for Al{sub x}Sc{sub 2-x}O{sub 3}. A k-value of ∝21 can be obtained for Gd{sub x}Sc{sub 2-x}O{sub 3} with approximately 26-52% Gd, irrespective of the Gd content. For Al{sub x}Sc{sub 2-x}O{sub 3} on the other hand, a maximum k-value of ∝19 is achieved with ∝48% Al. Although the k-value of Al{sub x}Sc{sub 2-x}O{sub 3} is lower than that of Gd{sub x}Sc{sub 2-x}O{sub 3}, its large breakdown field makes this material more suitable for HFG flash applications. (copyright 2014 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  10. Spark plasma sintering of aluminum powders prealloyed with scandium additions

    Energy Technology Data Exchange (ETDEWEB)

    Cooke, R.W.; Kraus, N.P.; Bishop, D.P., E-mail: Paul.Bishop@dal.ca

    2016-03-07

    The objective of this research was to commence work on the spark plasma sintering (SPS) of Al–Sc alloys in an effort to develop fundamental data in this area. In this precursory study, a series of binary systems containing 0.1 to 0.4 wt% Sc were processed in laboratory and industrial-scale equipment. Data revealed that all powders were responsive to SPS in both scenarios and that sintering temperature was a variable of critical importance. Hardness of as-sintered products scaled directly with Sc concentration but varied inversely with SPS temperature owing to in-situ aging of the raw powders. Hardness losses could be recovered through a post-SPS heat treatment into the T6 condition. Industrially processed slugs of Al-0.4Sc-T6 exhibited full densification and offered the highest hardness (786+/−8 MPa). This was accompanied by a nominal tensile yield strength of 197 MPa, UTS of 226 MPa and tensile ductility of 11%.

  11. Tin etching from metallic and oxidized scandium thin films

    NARCIS (Netherlands)

    Pachecka, Malgorzata; Lee, Christopher James; Sturm, J.M.; Bijkerk, Frederik

    The role of oxide on Sn adhesion to Sc surfaces was studied with in-situ ellipsometry, X-ray photoelectron spectroscopy and secondary electron microscopy. Sn etching with hydrogen radicals was performed on metallic Sc, metallic Sc with a native oxide, and a fully oxidized Sc layer. The results show

  12. The structural and magnetic properties of holmium/scandium superlattices

    DEFF Research Database (Denmark)

    Bryn-Jacobsen, C.; Cowley, R.A.; McMorrow, D.F.

    1997-01-01

    The properties of Ho/Sc superlattices grown by molecular beam epitaxy (MBE) have been investigated using X-ray and neutron diffraction techniques. Structural studies reveal the novel existence of more than one a lattice parameter. Examining the magnetic properties, it is found that the Ho 4f...

  13. Persistent self-consciousness about facial appearance, measured with the Derriford appearance scale 59, in patients after long-term biochemical remission of acromegaly

    NARCIS (Netherlands)

    Roerink, S.H.P.P.; Wagenmakers, M.A.E.M.; Wessels, J.F.; Sterenborg, R.B.; Smit, J.W.A.; Hermus, A.R.M.M.; Netea-Maier, R.T.

    2015-01-01

    CONTEXT: Acromegaly is associated with impaired quality of life (QoL) and causes anatomical disproportions, which may contribute to the decreased QoL after successful treatment. The Derriford appearance scale 59 (DAS59) is a questionnaire measuring psychological distress and disruptions to everyday

  14. 34 CFR 364.59 - May an individual's ability to pay be considered in determining his or her participation in the...

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false May an individual's ability to pay be considered in determining his or her participation in the costs of IL services? 364.59 Section 364.59 Education Regulations... individual's ability to pay be considered in determining his or her participation in the costs of IL services...

  15. Phosphorylation of Kaposi's Sarcoma-Associated Herpesvirus Processivity Factor ORF59 by a Viral Kinase Modulates Its Ability To Associate with RTA and oriLyt

    Science.gov (United States)

    McDowell, Maria E.; Purushothaman, Pravinkumar; Rossetto, Cyprian C.; Pari, Gregory S.

    2013-01-01

    ORF59 of Kaposi's sarcoma-associated herpesvirus (KSHV) plays an essential role in viral lytic replication by providing DNA processivity activity to the viral DNA polymerase (ORF9). ORF59 forms a homodimer in the cytoplasm and binds and translocates ORF9 into the nucleus, where it secures ORF9 to the origin of lytic DNA replication (oriLyt) in order to synthesize long DNA fragments during replication. ORF59 binds to oriLyt through an immediate early protein, replication and transcription activator (RTA). Here, we show that viral kinase (ORF36) phosphorylates serines between amino acids 376 and 379 of ORF59 and replacement of the Ser378 residue with alanine significantly impairs phosphorylation. Although mutating these serine residues had no effect on binding between ORF59 and ORF9, viral polymerase, or ORF36, the viral kinase, it significantly reduced the ability of ORF59 to bind to RTA. The results for the mutant in which Ser376 to Ser379 were replaced by alanine showed that both Ser378 and Ser379 contribute to binding to RTA. Additionally, the Ser376, Ser378, and Ser379 residues were found to be critical for binding of ORF59 to oriLyt and its processivity function. Ablation of these phosphorylation sites reduced the production of virion particles, suggesting that phosphorylation is critical for ORF59 activity and viral DNA synthesis. PMID:23678174

  16. [Effect of RNA interference of CD59 gene on proliferation of non-small cell lung cancer cell line GLC-P in vitro].

    Science.gov (United States)

    Wu, Weidong; Liu, Dan; Hou, Wenjin; Yi, Yongsheng; Wang, Yuejun; Lin, Weijia

    2015-06-01

    To investigate the effect of CD59 gene inhibition mediated by RNA interference on the proliferation and apoptosis of non-small cell lung cancer (NSCLC) GLC-P cells in vitro. Recombinant plasmids for RNA interference of CD59 gene were constructed and transfected into GLC-P cells via lipofectamine 2000. The stably transfected cells were examined with real-time RT-PCR, MTT assay and enzyme-linked immunosorbent assay to investigate the changes in cell proliferation and apoptosis. Compared with the control cells, the cells transfected with CD59-siRNA showed significantly decreased expression levels of CD59 mRNA (PRNA interference-mediated CD59 silencing can strongly inhibit the proliferation and induce apoptosis in GLC-P cells, which shed light on a potentially new target for targeted gene therapy of NSCLC.

  17. Correlations between hemoglobin, serum ferritin, and soluble transferrin receptor levels in children aged 6-59 months

    Directory of Open Access Journals (Sweden)

    Fajar Diah Tri Kusumastuti

    2014-04-01

    Full Text Available Background Early detection of iron deficiency is important in young children to prevent iron deficiency anemia, which may cause permanent neurocognitive development disorders. Hemoglobin level is an insensitive tool for detecting iron deficiency without anemia, while serum ferritin levels may be influenced by infection and inflammation. However, soluble transferrin receptor (sTfR is a sensitive marker for detecting iron deficiency, yet not widely used in daily practice. Objective To assess for correlations between hemoglobin, serum ferritin, and soluble transferrin receptor levels in children aged 6-59 months. Methods We performed a cross-sectional study in the Yogyakarta and Bantul Districts involving 85 children aged 6-59 months who visited integrated health posts (posyandu and who met the inclusion criteria. Subjects were chosen by cluster random sampling. Blood specimens were collected to examine hemoglobin, serum ferritin, and sTfR levels. Results Spearman’s correlation test revealed weak negative correlations between hemoglobin and serum ferritin levels, as well as between hemoglobin and sTfR levels, with coefficient correlations of r = -0.220, (P=0.043 and r = -0.317, (P=0.003, respectively. There was no correlation between serum ferritin and sTfR levels (r = -0.033; P=0.767. Conclusion Hemoglobin levels has weak negative correlations with serum ferritin and sTfR, but serum ferritin does not correlate with sTfR. [Paediatr Indones. 2014;54:122-6.

  18. Influenza A/H1N1 MF59 adjuvanted vaccine in pregnant women and adverse perinatal outcomes: multicentre study

    Science.gov (United States)

    Micone, P; Bonotti, A; Wainer, V; Schwarcz, A; Augustovski, F; Pichon Riviere, A; Karolinski, A

    2013-01-01

    Objective To assess the risk of adverse perinatal events of vaccination of pregnant women with an MF59 adjuvanted vaccine. Design Cross sectional multicentre study. Setting 49 public hospitals in major cities in Argentina, from September 2010 to May 2011. Participants 30 448 mothers (7293 vaccinated) and their 30 769 newborns. Main outcome measure Primary composite outcome of low birth weight, preterm delivery, or fetal or early neonatal death up to seven days postpartum. Results Vaccinated women had a lower risk of the primary composite outcome (7.0% (n=513) v 9.3% (n=2160); adjusted odds ratio 0.80, 95% confidence interval 0.72 to 0.89). The propensity score analysis showed similar results. Adjusted odds ratios for vaccinated women were 0.74 (0.65 to 0.83) for low birth weight, 0.79 (0.69 to 0.90) for preterm delivery, and 0.68 (0.42 to 1.06) for perinatal mortality. These findings were consistent in further subgroup analysis. No significant differences in maternal outcomes were found. Conclusion This large study using primary data collection found that MF59 adjuvanted A/H1N1 influenza vaccine did not result in an increased risk of adverse perinatal events and suggested a lower risk among vaccinated women. These findings should contribute to inform stakeholders and decision makers on the prescription of vaccination against influenza A/H1N1 in pregnant women. PMID:23381200

  19. Validity and reliability of Preschool Language Scale 4 for measuring language development in children 48-59 months of age

    Directory of Open Access Journals (Sweden)

    Nuryani Sidarta

    2016-04-01

    Full Text Available Prevalence rates for speech and language delay have been reported across wide ranges. Speech and language delay affects 5% to 8% of preschool children, often persisting into the school years.  A cross-sectional study was conducted in 208 children aged 48-59 months to determine the validity and reliability of the Indonesian edition of the Preschool Language Scale version 4 (PLS4 as a screening tool for the identification of language development disorders. Construct validity was examined by using Pearson correlation coefficient. Internal consistency was tested and repeated measurements were taken to establish the stability coefficient and intraclass correlation coefficients (ICC for test-retest reliability. For construct validity, the Pearson correlation coefficient ranged from 0.151-0.526, indicating that all questions in this instrument were valid for measuring auditory comprehension (AC and expressive communication skills (EC. Cronbach’s alpha level ranged from 0.81-0.95 with standard error of measurement (SEM ranging from 3.1-3.3. Stability coefficients ranged from 0.98-.0.99 with ICC coefficient ranging from 0.97-0.99 both of which showed an excellent reliability. This study found that PLS-4 is a valid and reliable instrument. It is easy to handle and can be recommended for assessing language development in children aged 48-59 months.

  20. The ORF59 DNA polymerase processivity factor homologs of Old World primate RV2 rhadinoviruses are highly conserved nuclear antigens expressed in differentiated epithelium in infected macaques

    Directory of Open Access Journals (Sweden)

    Burnside Kellie L

    2009-11-01

    Full Text Available Abstract Background ORF59 DNA polymerase processivity factor of the human rhadinovirus, Kaposi's sarcoma-associated herpesvirus (KSHV, is required for efficient copying of the genome during virus replication. KSHV ORF59 is antigenic in the infected host and is used as a marker for virus activation and replication. Results We cloned, sequenced and expressed the genes encoding related ORF59 proteins from the RV1 rhadinovirus homologs of KSHV from chimpanzee (PtrRV1 and three species of macaques (RFHVMm, RFHVMn and RFHVMf, and have compared them with ORF59 proteins obtained from members of the more distantly-related RV2 rhadinovirus lineage infecting the same non-human primate species (PtrRV2, RRV, MneRV2, and MfaRV2, respectively. We found that ORF59 homologs of the RV1 and RV2 Old World primate rhadinoviruses are highly conserved with distinct phylogenetic clustering of the two rhadinovirus lineages. RV1 and RV2 ORF59 C-terminal domains exhibit a strong lineage-specific conservation. Rabbit antiserum was developed against a C-terminal polypeptide that is highly conserved between the macaque RV2 ORF59 sequences. This anti-serum showed strong reactivity towards ORF59 encoded by the macaque RV2 rhadinoviruses, RRV (rhesus and MneRV2 (pig-tail, with no cross reaction to human or macaque RV1 ORF59 proteins. Using this antiserum and RT-qPCR, we determined that RRV ORF59 is expressed early after permissive infection of both rhesus primary fetal fibroblasts and African green monkey kidney epithelial cells (Vero in vitro. RRV- and MneRV2-infected foci showed strong nuclear expression of ORF59 that correlated with production of infectious progeny virus. Immunohistochemical studies of an MneRV2-infected macaque revealed strong nuclear expression of ORF59 in infected cells within the differentiating layer of epidermis corroborating previous observations that differentiated epithelial cells are permissive for replication of KSHV-like rhadinoviruses

  1. D 59 Design Guidelines

    DEFF Research Database (Denmark)

    Burcharth, Hans F.; Lamberti, Alberto

    The present guidelines are specifically dedicated to Low Crested Structures on attempt to provide methodological tools both for the engineering design of structures and for prediction of performance and environmental impacts. It is anticipated that the guidelines will provide valuable inputs to c...

  2. 59th Annual Meeting

    Indian Academy of Sciences (India)

    1993-10-01

    Oct 1, 1993 ... management', D A Mooley on the 'Origin, incidence and impact of droughts over India and remedial measures for their mitigation', P V. Joseph on 'Tropical .... Problems and perspectives" by K V S Rao,. International Centre for Genetic Engineering and. Biotechnology, New Delhi. In the morning session on ...

  3. Indexes to Volume 59

    Indian Academy of Sciences (India)

    221–228. Generic entangling through quantum indistinguishability. Sougato Bose and Dipankar Home. 229–234. Decoherence control in quantum computing with simple chirped pulses. Debabrata Goswami. 235–242. 1081 .... A high resolution AMS-injector for the Pelletron in Lund. R Hellborg,. S Bazhal, M Faarinen, K H ...

  4. Chapter 59: Web Services

    Science.gov (United States)

    Graham, M. J.

    Web services are a cornerstone of the distributed computing infrastructure that the VO is built upon yet to the newcomer, they can appear to be a black art. This perception is not helped by the miasma of technobabble that pervades the subject and the seemingly impenetrable high priesthood of actual users. In truth, however, there is nothing conceptually difficult about web services (unsurprisingly any complexities will lie in the implementation details) nor indeed anything particularly new. A web service is a piece of software available over a network with a formal description of how it is called and what it returns that a computer can understand. Note that entities such as web servers, ftp servers and database servers do not generally qualify as they lack the standardized description of their inputs and outputs. There are prior technologies, such as RMI, CORBA, and DCOM, that have employed a similar approach but the success of web services lies predominantly in its use of standardized XML to provide a language-neutral way for representing data. In fact, the standardization goes further as web services are traditionally (or as traditionally as five years will allow) tied to a specific set of technologies (WSDL and SOAP conveyed using HTTP with an XML serialization). Alternative implementations are becoming increasingly common and we will cover some of these here. One important thing to remember in all of this, though, is that web services are meant for use by computers and not humans (unlike web pages) and this is why so much of it seems incomprehensible gobbledegook. In this chapter, we will start with an overview of the web services current in the VO and present a short guide on how to use and deploy a web service. We will then review the different approaches to web services, particularly REST and SOAP, and alternatives to XML as a data format. We will consider how web services can be formally described and discuss how advanced features such as security, state and asynchrony can be provided. Note that much of this material is not yet used in the VO but features heavily in IVOA discussions on advanced services and capabilities.

  5. 59 - 62 lawan paid

    African Journals Online (AJOL)

    DR. AMIN

    crops and weeds growing near to it. The leaves of. Eucalyptus species are main releasing source of toxic compounds (Khan et al., 2008). The present study was aimed at investigating the effect of allelochemicals present in some Eucalyptus species aqueous leaf extract on germination and radicle length of Arachis hypogea.

  6. 59 - 62 lawan paid

    African Journals Online (AJOL)

    DR. AMIN

    “allelopathy” signifies the interactions between plants which might lead to either stimulation or inhibition of growth. Different groups of plants like; algae, lichens, crops and annuals and perennial weeds have wide known allelopathic interactions (Ahmad et al., 2004;. Uddin et al., 2007). Several phytotoxic substances causing ...

  7. 56 - 59 Dambatta 2

    African Journals Online (AJOL)

    DR. AMIN

    bacterial resistance to antibacterial drugs, the plant may be used as promising candidate for drug development. Keywords: Antibacterial ... the current global upsurge of bacterial resistance to antimicrobial drugs (Sale, and Doughari, .... brick red precipitate was confirmatory for the presence of glycosides. RESULTS. Table 1 ...

  8. Page 53 - 59.pmd

    African Journals Online (AJOL)

    Administrator

    Predictors of conformity were: duration in service of less than 6 years. (OR=3.40. CI=1.24-9.33), prescriber's profession (OR=97.51, CI=27.29-348.34) and diagnosis of uncomplicated malaria. (OR=10.13, CI=3.37-30.42). Conclusions: Adequate training and provision of information relevant to the needs of different cadres of ...

  9. KP59 METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  10. Adeno-associated virus mediated delivery of a non-membrane targeted human soluble CD59 attenuates some aspects of diabetic retinopathy in mice.

    Directory of Open Access Journals (Sweden)

    Mehreen Adhi

    Full Text Available Diabetic retinopathy is the leading cause of visual dysfunction in working adults and is attributed to retinal vascular and neural cell damage. Recent studies have described elevated levels of membrane attack complex (MAC and reduced levels of membrane associated complement regulators including CD55 and CD59 in the retina of diabetic retinopathy patients as well as in animal models of this disease. We have previously described the development of a soluble membrane-independent form of CD59 (sCD59 that when delivered via a gene therapy approach using an adeno-associated virus vector (AAV2/8-sCD59 to the eyes of mice, can block MAC deposition and choroidal neovascularization. Here, we examine AAV2/8-sCD59 mediated attenuation of MAC deposition and ensuing complement mediated damage to the retina of mice following streptozotocin (STZ induced diabetes. We observed a 60% reduction in leakage of retinal blood vessels in diabetic eyes pre-injected with AAV2/8-sCD59 relative to negative control virus injected diabetic eyes. AAV2/8-sCD59 injected eyes also exhibited protection from non-perfusion of retinal blood vessels. In addition, a 200% reduction in retinal ganglion cell apoptosis and a 40% reduction in MAC deposition were documented in diabetic eyes pre-injected with AAV2/8-sCD59 relative to diabetic eyes pre-injected with the control virus. This is the first study characterizing a viral gene therapy intervention that targets MAC in a model of diabetic retinopathy. Use of AAV2/8-sCD59 warrants further exploration as a potential therapy for advanced stages of diabetic retinopathy.

  11. Clinical evaluation of MPT-64 and MPT-59, two proteins secreted from Mycobacterium tuberculosis, for skin test reagents

    DEFF Research Database (Denmark)

    Wilcke, J T; Jensen, B N; Ravn, P

    1996-01-01

    SETTING: Department of Pulmonary Medicine P, Bispebjerg Hospital, Copenhagen, Denmark. OBJECTIVE: To study the ability of two proteins secreted from Mycobacterium tuberculosis, MPT-64 and MPT-59 to induce delayed type hypersensitivity (DTH) reactions following intradermal administration. DESIGN...... of the experimental skin test antigens had properties superior to tuberculin PPD RT23 in humans. The failure of MPT-64 to induce delayed type hypersensitivity reactions in the majority of tuberculosis patients is discussed, in view of the potent reactivity to MPT-64 in tuberculous guinea pigs.......: In a small scale clinical investigation, skin reactions to these antigens were compared to reactions to tuberculin PPD RT23 in 1) patients with active tuberculosis, 2) BCG vaccinated healthy subjects with close contact with tuberculous patients, and 3) BCG vaccinated healthy subjects without contact...

  12. Changes in Polish law related to the implementation of COUNCIL DIRECTIVE 2013/59/EURATOM of 5 December 2013

    Directory of Open Access Journals (Sweden)

    Wołoszczuk Katarzyna

    2018-01-01

    Full Text Available Radon is an invisible, naturally occurring radioactive noble gas. According to the WHO report, it is the most important cause of lung cancer after smoking [1]. Recent epidemiological studies show that a statistically significant increase in the risk of lung cancer already occurs as a result of prolonged exposure to radon inside rooms where the concentration is at 100 Bq/m3 and increases by 16% per 100 Bq/m3 increase (considering a prolonged exposure period. For this reason, the Council Directive 2013/59/Euratom (BSS [2] establishing the basic safety standards for the protection against the hazards related to ionizing radiation, that was passed in 2013, pays particular attention to issues related to radon exposure. BSS reduce radon concentration limits in workplaces to 300 Bq/m3. According to the regulations in force, the BSS must be implemented in the Polish Atomic Law no later than 6th February 2018.

  13. JT9D-70/59 Improved High Pressure Turbine Active Clearance Control System. [for specific fuel consumption improvement

    Science.gov (United States)

    Gaffin, W. O.

    1979-01-01

    The JT9D-70/59 high pressure turbine active clearance control system was modified to provide reduction of blade tip clearance when the system is activated during cruise operation. The modification increased the flow capacity and air impingement effectiveness of the cooling air manifold to augment turbine case shrinkage capability, and increased responsiveness of the airseal clearance to case shrinkage. The simulated altitude engine testing indicated a significant improvement in specific fuel consumption with the modified system. A 1000 cycle engine endurance test showed no unusual wear or performance deterioration effects on the engine or the clearance control system. Rig tests indicated that the air impingement and seal support configurations used in the engine tests are near optimum.

  14. A 59-year sedimentary record of metal pollution in the sediment core from the Huaihe River, Huainan, Anhui, China.

    Science.gov (United States)

    Wang, Jie; Liu, Guijian; Zhang, Jiamei; Liu, Houqi; Lam, Paul K S

    2016-12-01

    An approximately 59-year (1955-2014) sedimentary record of metal elements (Cu, Pb, Zn, Ni, Co, Mn, and Fe) in a sediment core, collected from the Huaihe River, Huainan City, Anhui Province, China, was reconstructed by using (210)Pb geochronology. Copper, Zn, Ni, Co, and Mn evaluated by enrichment factor (EF) indicated minor contamination due to water pollution accidents of the Huaihe River that occurred in 1990s and 2004. Lead presented the most severe pollution among the metals studied, especially during 1957-1974. The use of leaded petrol and atmospheric deposition of coal combustion flue gases could have contributed to Pb contamination. In spite of the general good quality (mean sediment pollution index (SPI) 35.69) of the sediment core evaluated by SPI based on the principal component analysis, worse sediment qualities in the upper section (<6 cm, 2004) were still observed, suggesting intensive human activities causing the increasing concentrations of metals in recent decades.

  15. Immunity against diphtheria and tetanus in human immunodeficiency virus-infected Danish men born 1950-59

    DEFF Research Database (Denmark)

    Kurtzhals, J A; Kjeldsen, K; Heron, I

    1992-01-01

    To evaluate the possible need for vaccination against diphtheria and tetanus of patients infected with the human immunodeficiency virus (HIV), antibodies were measured in blood samples from 78 Danish HIV-infected men, born 1950-59, who could be expected to have received primary vaccination before...... they contracted the HIV infection. No patients (95% confidence interval: 0-4) had tetanus antibodies below the protective level, whereas 24 of the 78 patients (16-33) were unprotected against diphtheria. In the background population of the same age group and sex, 5% and 10% have been found unprotected against...... tetanus and diphtheria, respectively. No relationship between disease stages and antibody levels could be found. Neither was there any difference between patients with normal and reduced numbers of CD4+ lymphocytes. From 25 patients two blood samples were taken at an interval of at least one year. Anti...

  16. 59 fs mode-locked Yb:KGW oscillator pumped by a single-mode laser diode

    Science.gov (United States)

    Kowalczyk, M.; Sotor, J.; Abramski, K. M.

    2016-03-01

    In this letter we present a passively mode-locked Yb:KGW oscillator pumped by a low power single-mode laser diode. Contrary to high power operation, single-mode pumping enabled us to suppress parasitic thermal effects, while keeping the setup compact and its alignment straightforward. Undisturbed mode-locking (ML) stability was achieved without active cooling of the gain medium and the laser was entirely self-starting. Pulses 59 fs in duration were obtained in a semiconductor saturable absorber mirror (SESAM)-assisted Kerr-lens mode-locked regime. The corresponding spectrum was 20.2 nm broad at a central wavelength of 1036 nm approaching the performance limit of the crystal. To the best of our knowledge, these are the shortest pulses generated from a Yb:KGW laser.

  17. Changes in Polish law related to the implementation of COUNCIL DIRECTIVE 2013/59/EURATOM of 5 December 2013

    Science.gov (United States)

    Wołoszczuk, Katarzyna; Skubacz, Krystian; Podgórska, Zuzanna

    2018-01-01

    Radon is an invisible, naturally occurring radioactive noble gas. According to the WHO report, it is the most important cause of lung cancer after smoking [1]. Recent epidemiological studies show that a statistically significant increase in the risk of lung cancer already occurs as a result of prolonged exposure to radon inside rooms where the concentration is at 100 Bq/m3 and increases by 16% per 100 Bq/m3 increase (considering a prolonged exposure period). For this reason, the Council Directive 2013/59/Euratom (BSS) [2] establishing the basic safety standards for the protection against the hazards related to ionizing radiation, that was passed in 2013, pays particular attention to issues related to radon exposure. BSS reduce radon concentration limits in workplaces to 300 Bq/m3. According to the regulations in force, the BSS must be implemented in the Polish Atomic Law no later than 6th February 2018.

  18. Determination of 63Ni and 59Ni in spent ion-exchange resin and activated charcoal from the IEA-R1 nuclear research reactor.

    Science.gov (United States)

    Taddei, M H T; Macacini, J F; Vicente, R; Marumo, J T; Sakata, S K; Terremoto, L A A

    2013-07-01

    A radiochemical method has been adapted to determine (59)Ni and (63)Ni in samples of radioactive wastes from the water cleanup system of the IEA-R1 nuclear research reactor. The process includes extraction chromatographic resin with dimethylglyoxime (DMG) as a functional group. Activity concentrations of (59)Ni and (63)Ni were measured, respectively, by X-ray spectrometry and liquid scintillation counting, whereas the chemical yield was determined by ICP-OES. The average ratio of measured activity concentrations of (63)Ni and (59)Ni agree well with theory. Copyright © 2013 Elsevier Ltd. All rights reserved.

  19. Faktor-faktor Yang Berhubungan Dengan Kejadian Underweight Pada Anak Usia 24-59 Bulan Di Nanggroe Aceh Darussalam (Nad): Analisis Data Surkesda Nad 2006

    OpenAIRE

    Mulyati, Sri; Sandjaja, Sandjaja; Tjandrarini, Dwi Hapsari

    2008-01-01

    Determinant Factors of The Incidence of Underweight Children Ageg 24-59 Month In Nanggroe Aceh Darussalam (NAD).Background: Surkesda NAD 2006 as post tsunami household health survey and covering all 21 districts/cities had assessed child nutritional status (underweight) for age 24-59 months, with cut-off point <-2.00 SD. A total sample of 1,437 children aged 0-59 months was included in the assessment.Objectives: The objective of this study is to analyze child nutritional status and factors...

  20. Drug-induced exposure of Schistosoma mansoni antigens SmCD59a and SmKK7.

    Directory of Open Access Journals (Sweden)

    Natalie Reimers

    2015-03-01

    Full Text Available BACKGROUND: Schistosomiasis is a serious health problem especially in developing countries and affects more than 243 million people. Only few anthelmintic drugs are available up to now. A major obstacle for drug treatment is the different developmental stages and the varying host compartments during worm development. Anthelmintic drugs have been tested mainly on adult schistosomes or freshly transformed cercariae. Knowledge concerning the larval stages is lacking. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we used in vitro-grown schistosomula (aged between 2 to 14 days to investigate drug effects of the three anthelmintics praziquantel, artemether, and oxamniquine. Further, we analyzed the antibody accessibility of two exemplary schistosome antigens SmCD59a and SmKK7, before and after drug treatment. Our results demonstrated that praziquantel applied at a concentration of 1 μM inhibited development of all life stages. Application of 10 μM praziquantel led to dramatic morphological changes of all schistosomula. Artemether at 1 and 10 μM had differential effects depending on whether it was applied to 2-day as compared to 7- and 14-day schistosomula. While 2-day schistosomula were not killed but inhibited from further development, severe morphological damage was seen in 7- and 14-day schistosomula. Oxamniquine (1 and 10 μM led to severe morphological impairment in all life stages. Analyzing the accessibility of the antigens SmCD59a and SmKK7 before drug treatment showed no antibody binding on living intact schistosomula. However, when schistosomula were treated with anthelmintics, both antigens became exposed on the larvae. Oxamniquine turned out to be most effective in promoting antibody binding to all schistosomula stages. CONCLUSION: This study has revealed marked differences in anthelmintic drug effects against larvae. Drug treatment increases surface antigen presentation and renders larvae accessible to antibody attack.

  1. Drug-Induced Exposure of Schistosoma mansoni Antigens SmCD59a and SmKK7

    Science.gov (United States)

    Höschler, Beate; Langhans, Kristina; Wilson, R. Alan; Pierrot, Christine; Khalife, Jamal; Grevelding, Christoph G.; Chalmers, Iain W.; Yazdanbakhsh, Maria; Hoffmann, Karl F.; Hokke, Cornelis H.; Haas, Helmut; Schramm, Gabriele

    2015-01-01

    Background Schistosomiasis is a serious health problem especially in developing countries and affects more than 243 million people. Only few anthelmintic drugs are available up to now. A major obstacle for drug treatment is the different developmental stages and the varying host compartments during worm development. Anthelmintic drugs have been tested mainly on adult schistosomes or freshly transformed cercariae. Knowledge concerning the larval stages is lacking. Methodology/Principal Findings In this study, we used in vitro-grown schistosomula (aged between 2 to 14 days) to investigate drug effects of the three anthelmintics praziquantel, artemether, and oxamniquine. Further, we analyzed the antibody accessibility of two exemplary schistosome antigens SmCD59a and SmKK7, before and after drug treatment. Our results demonstrated that praziquantel applied at a concentration of 1 μM inhibited development of all life stages. Application of 10 μM praziquantel led to dramatic morphological changes of all schistosomula. Artemether at 1 and 10 μM had differential effects depending on whether it was applied to 2-day as compared to 7- and 14-day schistosomula. While 2-day schistosomula were not killed but inhibited from further development, severe morphological damage was seen in 7- and 14-day schistosomula. Oxamniquine (1 and 10 μM) led to severe morphological impairment in all life stages. Analyzing the accessibility of the antigens SmCD59a and SmKK7 before drug treatment showed no antibody binding on living intact schistosomula. However, when schistosomula were treated with anthelmintics, both antigens became exposed on the larvae. Oxamniquine turned out to be most effective in promoting antibody binding to all schistosomula stages. Conclusion This study has revealed marked differences in anthelmintic drug effects against larvae. Drug treatment increases surface antigen presentation and renders larvae accessible to antibody attack. PMID:25774883

  2. Expression of CD55, CD59, and CD35 on red blood cells of β-thalassaemia patients

    Directory of Open Access Journals (Sweden)

    Ayşegül Uğur Kurtoğllu

    2017-05-01

    Full Text Available Aim of the study : β-thalassaemia (β-Thal is considered a severe, progressive haemolytic anaemia, which needs regular blood transfusions for life expectancy. Complement-mediated erythrocyte destruction can cause both intravascular and extravascular haemolysis. Complement regulatory proteins protect cells from such effects of the complement system. We aimed to perform quantitative analysis of membrane-bound complement regulators, CD55 (decay accelerating factor – DAF, CD35 (complement receptor type 1 – CR1, and CD59 (membrane attack complex inhibitory factor – MACIF on peripheral red blood cells by flow cytometry. Material and methods: The present study was carried out on 47 β-thalassemia major (β-TM patients, 20 β-thalassaemia intermedia (β-TI patients, and 17 healthy volunteers as control subjects. Results : CD55 levels of β-TM patients (58.64 ±17.06% were significantly decreased compared to β-TI patients (83.34 ±13.82% and healthy controls (88.57 ±11.69% (p < 0.01. CD59 levels of β-TM patients were not significantly different than β-TI patients and controls, but CD35 levels were significantly lower in the β-TM patients (3.56 ±4.87% and β-TI patients (12.48 ±9.19% than in the control group (39.98 ±15.01% (p < 0.01. Conclusions : Low levels of CD55 and CD35 in thalassaemia major patients indicates a role for them in the aetiopathogenesis of haemolysis in this disease, and also this defect in a complement system may be responsible for the chronic complications seen in these patients.

  3. The Constitutional Review Chamber of the Republic of Estonia : no. of the case 3-2-1-59-04 : date of decision 18 March 2005

    Index Scriptorium Estoniae

    2004-01-01

    Riigikohtu lahendi 3-2-1-59-04 (Eesti Vabariik ja AS Desintegraator kassatsioonkaebused Tallinna Ringkonnakohtu tsiviilkolleegiumi 12. 12. 2003 otsusele AS Desintegraator hagis Eesti Vabariigi vastu 411 000 krooni väljamõistmiseks) tekst inglise keeles

  4. Transforming growth factor-beta isoforms regulate the surface expression of membrane cofactor protein (CD46) and CD59 on human keratinocytes [corrected

    NARCIS (Netherlands)

    Pasch, M. C.; Bos, J. D.; Daha, M. R.; Asghar, S. S.

    1999-01-01

    We studied the regulation of the expression of complement regulatory proteins, membrane cofactor protein (MCP), decay accelerating factor (DAF) and CD59, on human keratinocytes by supernatant of activated mononuclear cells and by some individual cytokines present therein. Cultured keratinocytes

  5. 2017-10-02T05:59:02Z https://www.ajol.info/index.php/all/oai oai:ojs ...

    African Journals Online (AJOL)

    article/70154 2017-10-02T05:59:02Z jemdsa:ART Management of diabetic ketoacidosis Jivan, D diabetic ketoacidosis, fluid replacement, normal saline, Ringer's lactate, hyperchloraemic acidosis, insulin Although the mortality of diabetic ...

  6. Immunogenicity and safety of cell-derived MF59®-adjuvanted A/H1N1 influenza vaccine for children

    Science.gov (United States)

    Knuf, Markus; Leroux-Roels, Geert; Rümke, Hans; Rivera, Luis; Pedotti, Paola; Arora, Ashwani Kumar; Lattanzi, Maria; Kieninger, Dorothee; Cioppa, Giovanni Della

    2015-01-01

    Mass immunization of children has the potential to decrease infection rates and prevent the transmission of influenza. We evaluated the immunogenicity, safety, and tolerability of different formulations of cell-derived MF59-adjuvanted and nonadjuvanted A/H1N1 influenza vaccine in children and adolescents. This was a randomized, single-blind, multicenter study with a total of 666 healthy subjects aged 6 months–17 y in one of 3 vaccination groups, each receiving formulations containing different amounts of influenza A/H1N1 antigen with or without MF59. A booster trivalent seasonal MF59 vaccine was administered one year after primary vaccinations. Antibody titers were assessed by hemagglutination inhibition (HI) and microneutralization assays obtained on days 1, 22, 43, 366, and 387 (3 weeks post booster). Safety was monitored throughout the study. One vaccination with 3.75 μg of A/H1N1 antigen formulated with 50% MF59 (3.75_halfMF59) or 7.5 μg of A/H1N1 antigen formulated with 100% MF59 (7.5_fullMF59) induced an HI titer ≥1:40 in >70% of children in the 1–vaccinations with nonadjuvanted 15 μg A/H1N1 antigen were needed to achieve this response in the 1–children aged 6–11 months, 1 dose of 7.5_fullMF59 resulted in an HI titer ≥1:40 in >70% while 2 doses of 3.75_halfMF59 were required to achieve this result. All vaccines were well tolerated. Our findings support the immunogenicity and safety of the 3.75_halfMF59 (2 doses for children vaccine formulations for use in children and adolescents aged 6 months to 17 y The use of the 3.75_halfMF59 could have the benefit of antigen and adjuvant sparing, increasing the available vaccine doses allowing vaccination of more people. PMID:25621884

  7. NP-59 SPECT/CT Imaging in Stage 1 Hypertensive and Atypical Primary Aldosteronism: A 5-Year Retrospective Analysis of Clinicolaboratory and Imaging Features

    Directory of Open Access Journals (Sweden)

    Yi-Chun Chen

    2013-01-01

    Full Text Available Objective. We retrospectively analyzed all primary aldosteronism (PA patients undergoing NP-59 SPECT/CT imaging with regard to their clinicolaboratory and imaging features, investigation, and outcomes. Material and Methods. 11 PA patients who presented to our hospital for NP-59 SPECT/CT imaging between April 2007 and March 2012 and managed here were analyzed. Results. Among 11 PA patients, eight (73% had stage 1 hypertension, three (27% stage 2 hypertension, four (36% normal plasma aldosterone concentration, nine (82% nonsuppressed plasma renin activity (PRA, six (55% normal aldosterone-renin-ratio (ARR, eight (73% serum potassium ≧3 mEq/L, seven (64% subclinical presentation, seven (64% negative confirmatory testing, and four (36% inconclusive results on CT scan and seven (64% on planar NP-59 scan. All 11 (100% patients had positive results on NP-59 SPECT/CT scan. Two (18% met typical triad and nine (82% atypical triad. Among nine atypical PA patients, three (33% had clinical presentation, six (67% subclinical presentation, six (67% negative confirmatory testing, and four (44% inconclusive results on CT scan and six (67% on planar NP-59 scan. All patients had improved outcomes. Significant differences between typical and atypical PA existed in PRA and ARR. Conclusions. NP-59 SPECT/CT may provide diagnostic potential in stage 1 hypertensive and atypical PA.

  8. Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases.

    Science.gov (United States)

    Fukuzawa, Taku; Sampei, Zenjiro; Haraya, Kenta; Ruike, Yoshinao; Shida-Kawazoe, Meiri; Shimizu, Yuichiro; Gan, Siok Wan; Irie, Machiko; Tsuboi, Yoshinori; Tai, Hitoshi; Sakiyama, Tetsushi; Sakamoto, Akihisa; Ishii, Shinya; Maeda, Atsuhiko; Iwayanagi, Yuki; Shibahara, Norihito; Shibuya, Mitsuko; Nakamura, Genki; Nambu, Takeru; Hayasaka, Akira; Mimoto, Futa; Okura, Yuu; Hori, Yuji; Habu, Kiyoshi; Wada, Manabu; Miura, Takaaki; Tachibana, Tatsuhiko; Honda, Kiyofumi; Tsunoda, Hiroyuki; Kitazawa, Takehisa; Kawabe, Yoshiki; Igawa, Tomoyuki; Hattori, Kunihiro; Nezu, Junichi

    2017-04-24

    Dysregulation of the complement system is linked to the pathogenesis of a variety of hematological disorders. Eculizumab, an anti-complement C5 monoclonal antibody, is the current standard of care for paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). However, because of high levels of C5 in plasma, eculizumab has to be administered biweekly by intravenous infusion. By applying recycling technology through pH-dependent binding to C5, we generated a novel humanized antibody against C5, SKY59, which has long-lasting neutralization of C5. In cynomolgus monkeys, SKY59 suppressed C5 function and complement activity for a significantly longer duration compared to a conventional antibody. Furthermore, epitope mapping by X-ray crystal structure analysis showed that a histidine cluster located on C5 is crucial for the pH-dependent interaction with SKY59. This indicates that the recycling effect of SKY59 is driven by a novel mechanism of interaction with its antigen and is distinct from other known pH-dependent antibodies. Finally, SKY59 showed neutralizing effect on C5 variant p.Arg885His, while eculizumab does not inhibit complement activity in patients carrying this mutation. Collectively, these results suggest that SKY59 is a promising new anti-C5 agent for patients with PNH and other complement-mediated disorders.

  9. State of implementation of directive 2013/59/Euratom regarding radon protection in selected member states of the European Union; Stand der Umsetzung der Richtlinie 2013/59/Euratom hinsichtlich des Radonschutzes in ausgewaehlten Mitgliedstaaten der EU

    Energy Technology Data Exchange (ETDEWEB)

    Hurst, Stephanie [Saechsisches Staatsministerium fuer Umwelt und Landwirtschaft (Germany)

    2015-07-01

    Directive 2013/59/Euratom came 6th February 2014 into force. The member states have to implement the directive into national legislation until 6th of February 2018. According to different legal structures in the member states legislation will be comparable with regards to content, but may be implemented in different legal areas. Additionally the different current experience regarding radon regulation as well as different expertise with all aspects of radon protection will affect the implementation. Activities for implementation started in many member states, but at present it is not possible to make a mandatory statement for any member state, which modifications will come until 2018. On the other hand it is assumed that member states who have engaged themselves with radon protection issues since many years will not change their plans basically until 2018. The member states mentioned in the following text are chosen exemplary. A comprehensive compilation of the situation in all member states of the European Union was not possible. The inclusion of Switzerland resulted from the fact, that this European country is basically orientating its radon regulations on the international state of the art and international (also European) legislation.

  10. Measurement of {sup 63}Ni and {sup 59}Ni by accelerator mass spectrometry using characteristic projectile x-rays

    Energy Technology Data Exchange (ETDEWEB)

    McAninch, J.E.; Hainsworth, L.J.; Marchetti, A.A. [and others

    1996-05-01

    The long-lived isotopes of nickel ({sup 59}Ni, {sup 63}Ni) have current and potential use in a number of applications including cosmic radiation studies, biomedical tracing, characterization of low-level radioactive wastes, and neutron dosimetry. Methods are being developed at LLNL for the routine detection of these isotopes by AMS. One intended application is in Hiroshima dosimetry. The reaction {sup 63}Cu(n,p){sup 63}Ni has been identified as one of a small number of reactions which might be used for the direct determination of the fast neutron fluence emitted by the Hiroshima bomb. AMS measurement of {sup 63}Ni(t{sub 1/2} = 100 y) requires the chemical removal of {sup 63}Cu, which is a stable isobar of {sup 63}Ni. Following the electrochemical separation of Ni from gram-sized copper samples, the Cu concentration is further lowered to < 2 x 10{sup -8} (Cu/Ni) using the reaction of Ni with carbon monoxide to form the gas Ni(CO){sub 4}. The Ni(CO){sub 4} is thermally decomposed directly in sample holders for measurement by AMS. After analysis in the AMS spectrometer, the ions are identified using characteristic projectile x-rays, allowing further rejection of remaining {sup 63}Cu. In a demonstration experiment, {sup 63}Ni was measured in Cu wires (2-20 g) which had been exposed to neutrons from a {sup 252}Cf source. We successfully measured {sup 63}Ni at levels necessary for the measurement of Cu samples exposed near the Hiroshima hypocenter. For the demonstration samples, the Cu content was chemically reduced by a factor of 10{sup 12} with quantitative retention of {sup 63}Ni. Detection sensitivity (3{sigma}) was {approximately}20 fg {sup 63}Ni in 1 mg Ni carrier ({sup 63}Ni/Ni {approx} 2 x 10{sup -11}). Significant improvements in sensitivity are expected with planned incremental changes in the methods. Preliminary results indicate that a similar sensitivity is achievable for {sup 59}Ni (t{sub 1/2} = 10{sup 5} y).

  11. Characterization and comparison of 2 distinct epidemic community-associated methicillin-resistant Staphylococcus aureus clones of ST59 lineage.

    Directory of Open Access Journals (Sweden)

    Chih-Jung Chen

    Full Text Available Sequence type (ST 59 is an epidemic lineage of community-associated (CA methicillin-resistant Staphylococcus aureus (MRSA isolates. Taiwanese CA-MRSA isolates belong to ST59 and can be grouped into 2 distinct clones, a virulent Taiwan clone and a commensal Asian-Pacific clone. The Taiwan clone carries the Panton-Valentine leukocidin (PVL genes and the staphylococcal chromosomal cassette mec (SCCmec VT, and is frequently isolated from patients with severe disease. The Asian-Pacific clone is PVL-negative, carries SCCmec IV, and a frequent colonizer of healthy children. Isolates of both clones were characterized by their ability to adhere to respiratory A549 cells, cytotoxicity to human neutrophils, and nasal colonization of a murine and murine sepsis models. Genome variation was determined by polymerase chain reaction of selected virulence factors and by multi-strain whole genome microarray. Additionally, the expression of selected factors was compared between the 2 clones. The Taiwan clone showed a much higher cytotoxicity to the human neutrophils and caused more severe septic infections with a high mortality rate in the murine model. The clones were indistinguishable in their adhesion to A549 cells and persistence of murine nasal colonization. The microarray data revealed that the Taiwan clone had lost the ø3-prophage that integrates into the β-hemolysin gene and includes staphylokinase- and enterotoxin P-encoding genes, but had retained the genes for human immune evasion, scn and chps. Production of the virulence factors did not differ significantly in the 2 clonal groups, although more α-toxin was expressed in Taiwan clone isolates from pneumonia patients. In conclusion, the Taiwan CA-MRSA clone was distinguished by enhanced virulence in both humans and an animal infection model. The evolutionary acquisition of PVL, the higher expression of α-toxin, and possibly the loss of a large portion of the β-hemolysin-converting prophage likely

  12. Increased expression of complement regulators CD55 and CD59 on peripheral blood cells in patients with EAHEC O104:H4 infection.

    Directory of Open Access Journals (Sweden)

    Werner Dammermann

    Full Text Available BACKGROUND: An outbreak of Shiga Toxin 2 (Stx-2 producing enterohemorrhagic and enteroaggregative E.coli (EAHEC O104H4 infection in May 2011 caused enterocolitis and an unprecedented high 22% rate of hemolytic uremic syndrome (HUS. The monoclonal anti-C5 antibody Eculizumab (ECU has been used experimentally in EAHEC patients with HUS but treatment efficacy is uncertain. ECU can effectively prevent hemolysis in paroxysmal nocturnal hemoglobinuria (PNH caused by a lack of complement-regulating CD55 and CD59 on blood cells. We hypothesized a low expression of CD55 and CD59, as seen in PNH, might correlate with HUS development in EAHEC patients. METHODS: 76 EAHEC patients (34 only gastrointestinal symptoms [GI], 23: HUS, 19: HUS and neurological symptoms [HUS/N] and 12 healthy controls (HC were tested for the expression of CD55 and CD59 on erythrocytes and leukocytes retrospectively. Additionally, the effect of Stx-2 on CD55 and CD59 expression on erythrocytes and leukocytes was studied ex vivo. RESULTS: CD55 expression on erythrocytes was similar in all patient groups and HC while CD59 showed a significantly higher expression in HUS and HUS/N patients compared to HC and the GI group. CD55 and CD59 expression on leukocytes and their subsets was significantly higher in all patient groups compared to HC regardless of treatment type. However, CD59 expression on erythrocytes was significantly higher in HUS and HUS/N patients treated combined with plasma separation (PS and ECU compared to HC. Adding Stx-2 ex vivo had no effect on CD55 and CD59 expression on leukocytes from HC or patients. CONCLUSION: HUS evolved independently from CD55 and CD59 expression on peripheral blood cells in EAHEC O104:H4 infected patients. Our data do not support a role for CD55 and CD59 in HUS development during EAHEC O104:H4 infection and point to a different mechanism within the complement system for HUS development in EAHEC patients.

  13. Effects of three interventions and determinants of full vaccination among children aged 12-59 months in Nyanza province, Kenya.

    Science.gov (United States)

    Kawakatsu, Y; Tanaka, J; Ogawa, K; Ogendo, K; Honda, S

    2015-11-01

    The purpose of this study is to describe the effects of the three main interventions and identify the individual and community determinants of full vaccination coverage among children aged 12-59 months in Nyanza province, Kenya. Cross-sectional study. We utilized three datasets. One is the Nyanza Province County-based Multiple Indicator Cluster Survey 2011. The other two datasets are the lists of community units and health facilities in Nyanza Province, Kenya. A three-level multilevel logistic regression analysis was performed. In the final model, the highest wealth quintile (AOR: 2.49; 95% CI: 1.333-4.642; P = 0.004), the community with high coverage of media devices (AOR: 1.50; 95% CI: 1.029-2.198; P = 0.035), the participation of mass immunization campaigns (AOR: 1.63; 95% CI: 1.153-2.303; P = 0.006) were the significant determinants of complete child vaccination. In conclusion, further implementation of mass immunization campaigns is the recommended intervention to increase the uptake of required vaccinations among children. In addition, further attention to the poor and the low coverage of media devices is necessary, since they are the most vulnerable population in terms of accessibility of vaccination services. Implementation community based activity, such as community health workers, would have a positive impact on vaccination coverage, if their performance is continuously high. Copyright © 2015 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

  14. Executive functions and sustained attention:Comparison between age groups of 19-39 and 40-59 years old

    Directory of Open Access Journals (Sweden)

    Camila Rosa de Oliveira

    Full Text Available ABSTRACT Few studies involving the cognition of middle-aged adults are available in the international literature, particularly investigating the process of cognitive aging, executive components and attention. Objectives: The aim of this study was to investigate whether there are differences in performance on neuropsychological tasks of executive functions and sustained attention between two age groups. Methods: The sample consisted of 87 adults aged from 19 to 59 years old, divided into two groups according to the age variable (younger adults and middle-aged adults. All participants were Brazilian and had no sensory, psychiatric or neurological disorders; subjects also had no history of alcohol abuse, and no self-reported use of illicit drugs or antipsychotics. The neuropsychological instruments administered were the Hayling Test, Trail Making Test, Bells Test and verbal fluency tasks. Results: Groups showed no significant differences in relation to sociodemographic variables, educational level or frequency of reading and writing habits. The younger adult group performed better than the middle-aged group on tasks that involved mainly processing speed, cognitive flexibility and lexical search. Conclusions: These findings serve as a valuable reference for cognitive processing in middle-aged adults, since a large number of comparative studies focus only on the younger and later phases of adulthood. Additional studies are needed to investigate possible interaction between different factors such as age and education.

  15. All-fiber high-power monolithic femtosecond laser at 1.59 µm with 63-fs pulse width

    Science.gov (United States)

    Hekmat, M. J.; Omoomi, M.; Gholami, A.; Yazdabadi, A. Bagheri; Abdollahi, M.; Hamidnejad, E.; Ebrahimi, A.; Normohamadi, H.

    2018-01-01

    In this research, by adopting an alternative novel approach to ultra-short giant pulse generation which basically originated from difficulties with traditional employed methods, an optimized Er/Yb co-doped double-clad fiber amplifier is applied to boost output average power of single-mode output pulses to a high level of 2-W at 1.59-µm central wavelength. Output pulses of approximately 63-fs pulse width at 52-MHz repetition rate are obtained in an all-fiber monolithic laser configuration. The idea of employing parabolic pulse amplification for stretching output pulses together with high-power pulse amplification using Er/Yb co-doped active fibers for compressing and boosting output average power plays crucial role in obtaining desired results. The proposed configuration enjoys massive advantages over previously reported literature which make it well-suited for high-power precision applications such as medical surgery. Detailed dynamics of pulse stretching and compressing in active fibers with different GVD parameters are numerically and experimentally investigated.

  16. Determinants of Anemia among Children Aged 6–59 Months Living in Kilte Awulaelo Woreda, Northern Ethiopia

    Science.gov (United States)

    Gebreegziabiher, Gebremedhin; Niggusie, Daniel

    2014-01-01

    Introduction. The aim of this study was to determine the prevalence of anemia and determinant factors among children aged 6–59 months living in Kilte Awulaelo Woreda, eastern zone. Method. A community based cross-sectional study was conducted during February 2013 among 6 tabias of Kilte Awulaelo Woreda, northern Ethiopia. A total of 568 children were selected by systematic random sampling method. Anthropometric data and blood sample were collected. Bivariate and multivariate logistic regression analyses were performed to identify factors related to anemia. Result. The mean hemoglobin level was 11.48 g/dl and about 37.3% of children were anemic. Children who were aged 6–23 months [AOR = 1.89: 95% CI (1.3, 2.8)], underweight [AOR = 2.05: 95% CI (1.3, 3.3)], having MUAC less than 12 cm [AOR = 3.35: 95% CI (2.1, 5.3)], and from households with annual income below 10,000 Ethiopian birr [AOR = 4.86: 95% CI (3.2, 7.3)] were more likely to become anemic. Conclusion. The prevalence of anemia among the children is found to be high. It was associated with annual household income, age, and nutritional status of the child. So, improving family income and increasing awareness of the mother/caregiver were important intervention. PMID:25302116

  17. Tratamento da doença hemorroidária com ligadura elástica: estudo prospectivo com 59 pacientes Rubber band ligation for the treatment of hemorrhoidal disease: prospective study with 59 patients

    Directory of Open Access Journals (Sweden)

    Marcel Machado da Motta

    2011-06-01

    Full Text Available A ligadura elástica (LE é considerada um método minimamente invasivo para o tratamento da doença hemorroidária (DH e apresenta vantagens em relação à hemorroidectomia, como: simplicidade de execução e realização ambulatorial sem o emprego de anestesia. Trata-se de um método eficaz, principalmente nos portadores de DH grau II. Porém, apresenta complicações, sendo as mais frequentes: dor, tenesmo, hematoquezia e retenção urinária. Alguns trabalhos mostram complicações mais graves, como sangramentos vultosos que necessitaram de hemotransfusão. Assim, este trabalho avaliou a eficácia e a morbidade do tratamento da DH pelo método da LE. Foi um estudo prospectivo, com 59 pacientes. Destes, cinco (8,5% eram portadores de DH grau I, 33 (55,9% de DH grau II e 21 (35,6% de DH grau III. Todos os pacientes foram submetidos pelo menos a duas sessões. Nas 135 sessões realizadas, encontramos: hematoquezia em 62 (45,9%, dor intensa em 39 (28,9%, sintomas vagais em 10 (7,4% e pseudoestrangulamento em um (0,7% sessão. A taxa de cura do prolapso hemorroidário entre os portadores de DH grau II foi de 87,9% e entre aqueles com DH grau III, de 76,2%. O tratamento da DH pelo método da ligadura elástica mostrou-se seguro e com boa taxa de cura.Rubber band ligation (RB is considered a minimally invasive method for the treatment of hemorrhoidal disease (HD and has advantages in relation to hemorrhoidectomy whereby: simplicity of execution, outpatient realization and no need of anesthesia. It is an effective method, especially in the HD grade II. However, shows complications, and the most frequents are: anal pain, tenesmus, hematochezia and urinary retention. Some studies have shown severe complications as major bleeding that needs blood transfusion. Thus, this study evaluated the effectiveness and the morbidity of the treatment of HD by the method of RB. It was a prospective study with 59 patients. Five (8,5% patients had HD graded in the

  18. Immunogenicity of trivalent influenza vaccines in patients with chronic kidney disease undergoing hemodialysis: MF59-adjuvanted versus non-adjuvanted vaccines.

    Science.gov (United States)

    Noh, Ji Yun; Song, Joon Young; Choi, Won Suk; Lee, Jacob; Seo, Yu Bin; Kwon, Young Joo; Ko, Gang Jee; Cha, Dae Ryong; Kang, Young Sun; Lee, Young-Ki; Cheong, Hee Jin; Kim, Woo Joo

    2016-11-01

    Patients with chronic kidney disease (CKD) are at an increased risk of morbidity and mortality from influenza. However, the immunogenicity of influenza vaccine is known to be attenuated in these patients. In this study, the immunogenicity of MF59-adjuvanted and non-adjuvanted trivalent influenza vaccines was compared in CKD patients undergoing hemodialysis (HD). During 2013-2014, 179 CKD patients undergoing HD participated in the study. The patients were randomized into either MF59-adjuvanted vaccine group or non-adjuvanted vaccine group and were immunized with the respective vaccine. Sera were collected prior to vaccination and at 1 month (88 patients in MF59-adjuvanted vaccine group and 86 patients in non-adjuvanted vaccine group) and 6 months post vaccination. Levels of hemagglutination inhibition antibodies were measured. The seroconversion rate of all 3 vaccine strains at 1 month post-vaccination was significantly higher in the MF59-adjuvanted group than in the non-adjuvanted group (47.7% vs. 17.4%, A/H1N1; 42.0% vs. 16.3%, A/H3N2; 31.8% vs. 7.0%, B, P vaccination, the fold increase in geometric mean titer from pre-vaccination for A/H1N1, A/H3N2 and B viruses was significantly greater in the MF59-adjuvanted group than in the non-adjuvanted group. In elderly patients (≥65 years), the seroconversion rate at 1 month post-vaccination against influenza B strain was higher in the MF59-adjuvanted group than in the non-adjuvanted group (33.3% vs. 7.1%, P = 0.03). The MF59-adjuvanted influenza vaccine showed better immunogenicity than the non-adjuvanted influenza vaccine in CKD patients undergoing HD.

  19. MF59 Mediates Its B Cell Adjuvanticity by Promoting T Follicular Helper Cells and Thus Germinal Center Responses in Adult and Early Life.

    Science.gov (United States)

    Mastelic Gavillet, Beatris; Eberhardt, Christiane S; Auderset, Floriane; Castellino, Flora; Seubert, Anja; Tregoning, John S; Lambert, Paul-Henri; de Gregorio, Ennio; Del Giudice, Giuseppe; Siegrist, Claire-Anne

    2015-05-15

    The early life influenza disease burden calls for more effective vaccines to protect this vulnerable population. Influenza vaccines including the MF59 oil-in-water adjuvant induce higher, broader, and more persistent Ab responses in adults and particularly in young, through yet undefined mechanisms. In this study, we show that MF59 enhances adult murine IgG responses to influenza hemagglutinin (HA) by promoting a potent T follicular helper cells (TFH) response, which directly controls the magnitude of the germinal center (GC) B cell response. Remarkably, this enhancement of TFH and GC B cells is already fully functional in 3-wk-old infant mice, which were fully protected by HA/MF59 but not HA/PBS immunization against intranasal challenge with the homologous H1N1 (A/California/7/2009) strain. In 1-wk-old neonatal mice, MF59 recruits and activates APCs, efficiently induces CD4(+) effector T cells and primes for enhanced infant responses but induces few fully functional TFH cells, which are mostly follicular regulatory T cells, and poor GC and anti-HA responses. The B cell adjuvanticity of MF59 appears to be mediated by the potent induction of TFH cells which directly controls GC responses both in adult and early life, calling for studies assessing its capacity to enhance the efficacy of influenza immunization in young infants. Copyright © 2015 by The American Association of Immunologists, Inc.

  20. Use of a polyanionic carbomer, Carbopol971P, in combination with MF59, improves antibody responses to HIV-1 envelope glycoprotein

    Science.gov (United States)

    Dey, Antu K.; Burke, Brian; Sun, Yide; Hartog, Karin; Heeney, Jonathan L.; Montefiori, David; Srivastava, Indresh K.; Barnett, Susan W.

    2012-01-01

    Identification of optimal antigen(s) and adjuvant combination(s) to elicit potent, protective, and long-lasting immunity has been a major challenge for the development of effective vaccines against chronic viral pathogens, such as HIV-1, for which there are not yet any licensed vaccines. Here we describe the use of a novel adjuvant approach employing Carbopol 971P® NF (hereafter referred to as Carbopol971P), a cross-linked polyanionic carbomer, in combination with the Novartis proprietary oil-in-water adjuvant, MF59, as a potentially safe and effective adjuvant to augment humoral immune responses to the HIV-1 envelope glycoprotein (Env). Intramuscular immunization of small animals with recombinant Env glycoprotein (gp140) formulated in Carbopol971P plus MF59 gave significantly higher titers of binding and virus neutralizing antibodies as compared to immunization using gp140 with either MF59 or Carbopol971P alone. In addition, the antibodies generated were of higher avidity. Importantly, the use of Carbopol971P plus MF59 did not cause any serious adverse reactions or any obvious health problems in animals upon intramuscular administration. Hence, the Carbopol971P plus MF59 adjuvant formulation may provide a benefit for future vaccine applications. PMID:22366638

  1. Factors Which Influenced the Success of the Implementation of the Regulation of the Minister of Home Affairs Number 59 of 2007 in North Sumatera Provincial Government

    Directory of Open Access Journals (Sweden)

    Amar Rinanda Lubis

    2016-06-01

    Full Text Available This study aimed to test empirically and analyze the influence of regulation, commitment, human resources and supporting devices to the successful implementation of the Regulation of the Minister of Home Affairs No.59 Year 2007. Population in this study is SKPD Officer of North Sumatra Province (108 people which was sampled for 93 people. Simultaneous F test and partial t test were used to studies effects of regulation, commitment, human resources and supporting facilities to the successful implementation of the Regulation of the Minister of Home Affairs No. 59, year 2007. These results prove that the regulation, commitment, human resources and supporting devices simultaneously influenced the successful implementation of the Regulation of the Minister of Home Affairs No. 59 Year 2007. In partial, regulation, commitment and human resources affected successful implementation of the Regulation of the Minister of Home Affairs No. 59 Year 2007, while the supporting facilities did not have an effect. These results showed that 48% variations of successful implementation of the Regulation of the Minister of Home Affairs No.59 Year 2007, depended on variable of regulation, commitment, human resources and supporting facilities and the remaining 52% depended on other uninvestigated variables.

  2. Risk factors of severe pneumonia among children aged 2-59 months in western Kenya: a case control study.

    Science.gov (United States)

    Onyango, Dickens; Kikuvi, Gideon; Amukoye, Evans; Omolo, Jared

    2012-01-01

    Globally, pneumonia is the leading cause of death in children under the age of 5 years. In Kenya, it is the second leading cause of mortality, accounting for greater than 30,000 deaths in this age group annually. This study sought to identify risk factors for severe pneumonia in children under the age of five years. We conducted a case control study. Cases were children aged 2 to 59 months with severe pneumonia or very severe pneumonia and controls were those with non-severe pneumonia as defined by the integrated management of childhood illnesses classification. We administered structured questionnaires to mothers of participants to obtain data on socio-demographics, nutritional status and potential environmental risk factors. Data was analyzed using Epi Info; significance level was set at 0.05. We recruited 103 cases and 103 controls. The median age of cases was 14.0 (Range 3-58) months and of controls 14.0 (Range 2-54) months. Comorbidity (Odds Ratio = 3.8, Confidence Interval 1.4-10.6), delay in seeking treatment for three days or more (Odds Ratio = 2.3, Confidence Interval 1.2-4.2) and contact with upper respiratory tract infection (Odds Ratio = 2.7, Confidence Interval 1.1-6.5) were independent risk factors for severe pneumonia. Receiving antibiotics at home (Odds Ratio = 0.4, Confidence Interval 0.2-0.8) was protective. Co-morbidity, contact with upper respiratory tract infection and delay in seeking treatment are risk factors for severe pneumonia. We recommend health education regarding appropriate health seeking and engaging community health workers in pneumonia prevention, control and treatment.

  3. Appearance distress and dysfunction in the elderly: international contrasts across Italy and the UK using DAS59.

    Science.gov (United States)

    Moss, Timothy P; Cogliandro, Annalisa; Pennacchini, Maddalena; Tambone, Vittoradolfo; Persichetti, Paolo

    2013-12-01

    As the global population grows, the percentage of those over 60 will escalate disproportionately. Their needs will become an ever more dominant feature of public policy and healthcare provision. Older adults' appearance is often removed from cultural ideals and stereotypes of beauty, often seen as synonymous with "youth." This has seen older adults' concerns about appearance and body image somewhat sidelined in practice and in research. This study investigates the extent to which self-consciousness of appearance is associated with distress and dysfunction in those over 60 years old. Furthermore, we contrast the extent of this phenomenon in two European nations, UK and Italy, and consider the direct impact and interaction of cultural context and participant gender. To make an objective measurement of distress and dysfunction, we translated a widely used psychometric measure, the Derriford Appearance Scale 59 following an established and reliable translation protocol. Data were collected from community samples. The Italian translation was sound, with acceptability in the Italian-speaking sample and acceptable internal consistency scores for full-scale and subscales. ANOVA analysis demonstrated that for overall adjustment, and all subscale scores, the Italians were more distressed about their appearance than UK comparators. Moreover, there were significant differences between Italian women and men, with Italian women more distressed than Italian men overall, and also general self-consciousness, sexual self-consciousness, and social self-consciousness subscales. These results are considered in the context of aging and cultural and gender issues in appearance, including the Italian concept of bella figura. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

  4. Lacosamide for uncontrolled primary generalized tonic-clonic seizures: An open-label pilot study with 59-week extension.

    Science.gov (United States)

    Wechsler, Robert T; Yates, Stephen L; Messenheimer, John; Leroy, Robert; Beller, Cynthia; Doty, Pamela

    2017-02-01

    Assess the safety of adjunctive lacosamide for the treatment of uncontrolled primary generalized tonic-clonic seizures in patients (16-65 years) with primary generalized (genetic) epilepsy (PGE). An open-label pilot safety study (SP0961; NCT01118949), comprising 12 weeks' historical baseline, 4 weeks' prospective baseline, 3 weeks' titration (target: 400mg/day adjunctive lacosamide) and 6 weeks' maintenance. Patients who continued to the extension study (SP0962; NCT01118962) then received ≤59 weeks of flexible treatment (100-800mg/day lacosamide with flexible dosing of concomitant antiepileptic drugs). The primary outcomes for SP0961 were the mean change (±standard deviation) in absence seizure or myoclonic seizure days per 28days from prospective baseline to maintenance; for SP0962, the incidence of treatment-emergent adverse events (TEAEs) and withdrawals because of TEAEs. Of the 49 patients who enrolled, 40 (82%) completed the pilot study and 9 discontinued (5 because of adverse events). Of the 39 patients who continued to the extension study, 10 discontinued (2 owing to TEAEs) and 29 (74%) completed the study. During the pilot study, patients reported a reduction in mean (±standard deviation) absence and myoclonic seizure days per 28days (-0.37±4.80, -2.19±5.80). Reductions were also observed during the extension study (-2.38±5.54, -2.78±6.43). Five patients in SP0961 and 2 patients in SP0962 experienced TEAEs of new or increased frequency of absence seizures or myoclonic seizures. The most common TEAEs during SP0961 were dizziness (39%) and nausea (27%), and during SP0962 were dizziness (26%) and upper respiratory tract infection (26%). The safety profile of adjunctive lacosamide was similar to that previously published. Adjunctive lacosamide did not systematically worsen absence or myoclonic seizures, and appears to be well tolerated in patients with PGE. Copyright © 2016. Published by Elsevier B.V.

  5. Immune reconstitution after allogeneic hematopoietic stem cell transplantation in children: a single institution study of 59 patients

    Directory of Open Access Journals (Sweden)

    Hyun O Kim

    2013-01-01

    Full Text Available &lt;b&gt;Purpose:&lt;/b&gt; Lymphocyte subset recovery is an important factor that determines the success of hematopoietic stem cell transplantation (HSCT. Temporal differences in the recovery of lymphocyte subsets and the factors influencing this recovery are important variables that affect a patient's posttransplant immune reconstitution, and therefore require investigation. &lt;b&gt;Methods:&lt;/b&gt; The time taken to achieve lymphocyte subset recovery and the factors influencing this recovery were investigated in 59 children who had undergone HSCT at the Department of Pediatrics, The Catholic University of Korea Seoul St. Mary's Hospital, and who had an uneventful follow-up period of at least 1 year. Analyses were carried out at 3 and 12 months post-transplant. An additional study was performed 1 month post-transplant to evaluate natural killer (NK cell recovery. The impact of preand post-transplant variables, including diagnosis of Epstein-Barr virus (EBV DNAemia posttransplant,on lymphocyte recovery was evaluated. &lt;b&gt;Results:&lt;/b&gt; The lymphocyte subsets recovered in the following order: NK cells, cytotoxic T cells, B cells,and helper T cells. At 1 month post-transplant, acute graft-versus-host disease was found to contribute significantly to the delay of CD16+/56+ cell recovery. Younger patients showed delayed recovery of both CD3+/CD8+ and CD19+ cells. EBV DNAemia had a deleterious impact on the recovery of both CD3+ and CD3+/CD4+ lymphocytes at 1 year post-transplant. &lt;b&gt;Conclusion:&lt;/b&gt; In our pediatric allogeneic HSCT cohort, helper T cells were the last subset to recover. Younger age and EBV DNAemia had a negative impact on the post-transplant recovery of T cells and B cells.

  6. Prevalência da anemia e fatores associados em crianças de seis a 59 meses de Pernambuco

    Directory of Open Access Journals (Sweden)

    Luciana Pedrosa Leal

    2011-06-01

    Full Text Available OBJETIVO: Estimar a prevalência de anemia e identificar seus fatores associados em crianças de seis a 59 meses. MÉTODOS: Estudo transversal com dados da III Pesquisa Estadual de Saúde e Nutrição/Pernambuco em amostra representativa de 1.403 crianças para as áreas urbana e rural. A anemia foi diagnosticada pela dosagem da hemoglobina. A análise multivariada foi realizada a partir de um modelo hierárquico, utilizando a regressão de Poisson, com variância robusta para estimar a razão de prevalência em função de variáveis: biológicas, de morbidade e estado nutricional da criança, socioeconômicas, de habitação, de saneamento e fatores maternos. RESULTADOS: A prevalência ponderada de anemia foi de 32,8%: 31,5% na área urbana e 36,6% na rural. Na área urbana, as variáveis que se associaram significantemente à anemia foram: escolaridade materna, bens de consumo, número de crianças menores de cinco anos no domicílio, tratamento da água de beber, idade e anemia materna e idade da criança. Na área rural, apenas a idade materna e a idade da criança associaram-se de modo significante à anemia. CONCLUSÕES: A prevalência de anemia nas crianças pernambucanas é semelhante nas áreas urbana e rural. Os fatores associados à anemia apresentados devem ser considerados no planejamento de medidas efetivas para o seu controle.

  7. Sex differences in child nutritional and immunological status 5-9 years post contact in fringe highland Papua New Guinea.

    Science.gov (United States)

    Decaro, Jason A; Decaro, Erin; Worthman, Carol M

    2010-01-01

    This study examines sex differences in vulnerability among children experiencing rapid culture change that may reflect distinct microecologies driven by differential parental investment and/or sex-specific life history strategies. Apparent female growth canalization may be a life history strategy favoring growth over maintenance but also may reflect sex-differentiated selection for resilience based on unequal treatment during early life. Stature, weight, and serum measures of C-reactive protein (CRP, an inflammation marker) and Epstein-Barr Virus antibodies (EBV, a humoral immune response marker) were collected longitudinally among children/adolescents ages 5-20 years (N = 65), 5-9 years after sustained contact in a fringe highland hunter-horticulturalist group from the Schrader Range in Papua New Guinea exhibiting male preference and sex-biased survival. It was hypothesized that girls would exhibit canalization, with better nutritional status than boys; lower maintenance investment would yield lower female immune activation; and because of differential survivorship, females would appear increasingly canalized as early conditions for girls worsened relative to boys. Girls had greater arm circumference z-scores than boys, less frequent stunting, and lower CRP despite high pathogen load. Average nutritional status for girls improved over time as the sex ratio became increasingly male biased and the condition of female infants reportedly worsened. Both canalization and survivorship effects were found. Although a life history perspective on female canalization can help explain developmental outcomes in populations undergoing rapid culture change amid adversity, possible sex differences in the strength of survivorship effects that select for resiliency should not be ignored. (c) 2010 Wiley-Liss, Inc.

  8. Prevalence and demographic factors associated with vitamin A deficiency in Colombian children aged 12-59 months.

    Science.gov (United States)

    Martínez-Torres, Javier; Meneses-Echavéz, José F; Ramírez-Vélez, Robinson

    2014-11-01

    To examine the sociodemographic factors associated with subclinical vitamin A deficiency in a representative sample of Colombian children. Subjects and methods A cross-sectional, descriptive study was conducted of data from the 2010 National Nutrition Survey of Colombia (ENSIN 2010) on 4,279 children aged 12 to 59 months. Plasma vitamin A levels were measured using high resolution liquid chromatography (HRLC), and sociodemographic factors (sex, age, ethnicity, SISBEN score, and geographic region) were collected using a structured survey. Prevalence rates and associations were established using a multivariate regression model. Vitamin A levels ranged from 7.5-93.7 μg/dL (mean=26.2; 95% CI, 25.9 to 26.5μg/dL). Vitamin A levels less than 20 μg/dL (subclinical deficiency) were found in 24.3% of children. Children belonging to ethnic groups of African ascent, those living in the Orinoquia and Amazonia regions, and those aged 12-23 months had the greatest subclinical vitamin A deficiencies (29.5%, 31.1%, and 27.6% respectively. Regression models showed that age ranging from 12 and 23 months (OR 1.32; 95% CI, 1.01 to 1.73), a SISBEN score 1 (OR 1.66; 95% CI, 1.18 to 2.34), an African ascent (OR 1.35; 95% CI, 1.05 to 1.74), and living in the Orinoquia and Amazonia regions (OR 2.38; 95% CI, 1.62 to 3.51) were factors associated to subclinical vitamin A deficiency. The study population shows a high prevalence of subclinical vitamin A deficiency, and comprehensive interventions involving nutritional and educational components are therefore recommended. Copyright © 2014 SEEN. Published by Elsevier Espana. All rights reserved.

  9. Immunogenicity, safety, and lot consistency of a novel inactivated enterovirus 71 vaccine in Chinese children aged 6 to 59 months.

    Science.gov (United States)

    Hu, Yue-Mei; Wang, Xu; Wang, Jun-Zhi; Wang, Ling; Zhang, Yong-Jie; Chang, Lin; Liang, Zheng-Lun; Xia, Jie-Lai; Dai, Qi-Gang; Hu, Ya-Ling; Mao, Qun-Ying; Zhu, Feng-Cai; Song, Yu-Fei; Gao, Fan; Chen, Jiang-Ting

    2013-12-01

    The determination of lot-to-lot consistency in the manufacturing process is a mandatory step in the clinical development of the novel enterovirus 71 (EV71) vaccine. A phase III, randomized, placebo-controlled, double-blind trial assessed the lot consistency, immunogenicity, and safety of the EV71 vaccine in children aged 6 to 59 months. Healthy children (n = 1,400) received one of three lots of the EV71 vaccine containing 400 U of EV71 antigen or a placebo at days 0 and 28. Blood samples were collected before dose 1 and at 28 days after dose 2 (day 56) for an anti-EV71 neutralizing antibody (NTAb) assay. The geometric mean titer (GMT) and the seropositivity rates (with titers of ≥1:8) were compared at day 56. After each dose, the solicited injection site and general adverse events (AEs) were recorded for 7 days, and unsolicited AEs were recorded for 28 days. At day 56, the seropositivity rates ranged from 99.7% to 100% for the vaccine groups. The NTAb GMTs for the vaccine were 140.3 (95% confidence interval [CI], 117.8 to 167.1), 141.5 (95% CI, 118.0 to 169.6), and 146.6 (95% CI, 122.5 to 175.3). The two-sided 95% CI of the log difference in GMTs between the pairs of lots were between -0.176 and 0.176, therefore meeting the predefined equivalence criteria. The percentages of subjects reporting any injection site AEs, general AEs, or serious AEs were similar across the four vaccination groups. In conclusion, the demonstration of consistency between the manufacturing lots confirms for the purposes of clinical development the reliability of the EV71 vaccine production process. (This study has been registered at ClinicalTrials.gov under registration no. NCT01636245.).

  10. The β-decay rates of 59Fe isotopes in shell burning environments and their influences on the production of 60Fe in massive star

    Directory of Open Access Journals (Sweden)

    Li K.

    2016-01-01

    Full Text Available The experimental B(GT strengths of the 59Fe excited states were employed to determine the transition strengths which greatly contribute 59Fe stellar β–decay at typical carbon shell burning temperature. The result has been compared with the theoretical rates FFN (Fuller-Fowler-Newman and LMP (Langanke&Martinez-Pinedo. Impact of the newly determined rate on the synthesis of cosmic γ emitter 60Fe has also been studied using one-zone model calculation. Our results show 59Fe stellar β−decay rate plays an important role in the 60Fe nucleosynthesis. However the uncertainty of the decay rate is rather large due to the error of B(GT strength that requires further studies.

  11. Removal of the Tag from His-tagged ILYd4, a Human CD59 Inhibitor, Significantly Improves its Physical Properties and its Activity

    Science.gov (United States)

    Wu, Lin; Su, Sanbao; Liu, Fengming; Xu, Tao; Wang, Xiaoxiao; Huang, Yan; Sun, Xinlu; Ge, Xiaowen; Chen, Ting; Liu, Huixia; Wang, Chun; Chorev, Michael; Xu, Ting; Qin, Xuebin

    2014-01-01

    Complement dependent cytotoxicity (CDC) significantly contributes to Rituximab (RTX) and Ofatumumab (OFA) efficacies in the treatment of B-cell non-Hodgkin’s lymphoma (NHL) and chronic lymphocytic leukemia (CLL). Human CD59 (hCD59) is a key complement regulatory protein that restricts the formation of the membrane attack complex and thereby inhibits CDC. hCD59 is an important determinant of the sensitivity of NHL and CLL to RTX and OFA treatment. Recently, we developed a specific and potent hCD59 inhibitor, His-tagged ILYd4, which consists of 30 amino acid sequences extending from the N-terminus of ILYd4. Our previously published results indicate that His-tagged ILYd4 can be used as a lead candidate to further develop a potential therapeutic adjuvant for RTX and OFA treatment of RTX-resistant NHL and CLL. However, these studies were conducted using ILYd4 tagged on the N-terminus with 30 additional amino acids (AA) containing 6 X His used for immobilized metal affinity chromatograph. As a further step towards the development of ILYd4-based therapeutics, we investigated the impact of the removal of this extraneous sequence on the anti-hCD59 activity. In this paper, we report the generation and characterization of tag-free ILYd4. We demonstrate that tag-free ILYd4 has over three-fold higher anti-hCD59 activities than the His-tagged ILYd4. The enhanced RTX-mediated CDC effect on B-cell malignant cells comes from tag-free ILYd4’s improved functionality and physical properties including better solubility, reduced tendency to aggregation, and greater thermal stability. Therefore, tag-free ILYd4 is a better candidate for the further development for the clinical application. PMID:22642361

  12. Interaction of Kaposi's sarcoma-associated herpesvirus ORF59 with oriLyt is dependent on binding with K-Rta.

    Science.gov (United States)

    Rossetto, Cyprian C; Susilarini, Ni Ketut; Pari, Gregory S

    2011-04-01

    Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 (HHV-8) displays two distinct life stages, latency and lytic reactivation. Progression through the lytic cycle and replication of the viral genome constitute an essential step toward the production of infectious virus and human disease. KSHV K-RTA has been shown to be the major transactivator required for the initiation of lytic reactivation. In the transient-cotransfection replication assay, K-Rta is the only noncore protein required for DNA synthesis. K-Rta was shown to interact with both C/EBPα binding motifs and the R response elements (RRE) within oriLyt. It is postulated that K-Rta acts in part to facilitate the recruitment of replication factors to oriLyt. In order to define the role of K-Rta in the initiation of lytic DNA synthesis, we show an interaction with ORF59, the DNA polymerase processivity factor (PF), one of the eight virally encoded proteins necessary for origin-dependent DNA replication. Using the chromatin immunoprecipitation (ChIP) assay, both K-Rta and ORF59 interact with the RRE and C/EBPα binding motifs within oriLyt in cells harboring the KSHV bacterial artificial chromosome (BAC). A transient-transfection ChIP assay demonstrated that the interaction of ORF59 with oriLyt is dependent on binding with K-Rta and that ORF59 fails to bind to oriLyt in the absence of K-Rta. Also, using the cotransfection replication assay, overexpression of the interaction domain of K-Rta with ORF59 has a dominant negative effect on oriLyt amplification, suggesting that the interaction of K-Rta with ORF59 is essential for DNA synthesis and supporting the hypothesis that K-Rta facilitates the formation of a replication complex at oriLyt.

  13. First Experimental Constraint on the Fe59(n ,γ)Fe60 Reaction Cross Section at Astrophysical Energies via the Coulomb Dissociation of Fe60

    Science.gov (United States)

    Uberseder, E.; Adachi, T.; Aumann, T.; Beceiro-Novo, S.; Boretzky, K.; Caesar, C.; Dillmann, I.; Ershova, O.; Estrade, A.; Farinon, F.; Hagdahl, J.; Heftrich, T.; Heil, M.; Heine, M.; Holl, M.; Ignatov, A.; Johansson, H. T.; Kalantar, N.; Langer, C.; Le Bleis, T.; Litvinov, Yu. A.; Marganiec, J.; Movsesyan, A.; Najafi, M. A.; Nilsson, T.; Nociforo, C.; Panin, V.; Pietri, S.; Plag, R.; Prochazka, A.; Rastrepina, G.; Reifarth, R.; Ricciardi, V.; Rigollet, C.; Rossi, D. M.; Savran, D.; Simon, H.; Sonnabend, K.; Streicher, B.; Terashima, S.; Thies, R.; Togano, Y.; Volkov, V.; Wamers, F.; Weick, H.; Weigand, M.; Wiescher, M.; Wimmer, C.; Winckler, N.; Woods, P. J.

    2014-05-01

    The radionuclide Fe60 has been of great interest to the nuclear astrophysics community for over a decade. An initial discrepancy between the observed and modeled Galactic Fe60/Al26 ratio motivated numerous studies focused on the nucleosynthesis of these two isotopes, though the cross section of the primary astrophysical production reaction, Fe59(n ,γ)Fe60, has remained purely theoretical. The present work offers a first experimental constraint on the Fe59(n ,γ)Fe60 cross section at astrophysical energies, obtained indirectly via Coulomb dissociation, and demonstrates that the theoretical reaction rates used in present stellar models are not highly erroneous.

  14. Albedo factors of some elements in the atomic number range 26≤Z≤79 for 59.54keV.

    Science.gov (United States)

    Yılmaz, Demet; Uzunoğlu, Zeynep; Demir, Celalettin

    2017-04-01

    In this study, we aimed to determine the albedo factors for Fe, Co, Ni, Cu, Zr, Mo, Ag, Dy, Yb, and Au. Albedo factors were investigated experimentally for 59.54keV photon energy by using an HPGe detector with a resolution of 182eV at 5.9keV. Albedo number (AN), albedo energy (AE), and albedo dose (AD) were plotted as a function of atomic number of the target. It was observed that albedo factors decreased with increasing atomic number. In addition, there was a good third-order polynomial relationship between the albedo factors and atomic number. Copyright © 2017. Published by Elsevier Ltd.

  15. A global assessment of the gender gap in self-reported health with survey data from 59 countries

    Directory of Open Access Journals (Sweden)

    Ties Boerma

    2016-07-01

    Full Text Available Abstract Background While surveys in high-income countries show that women generally have poorer self-reported health than men, much less is known about gender differences in other regions of the world. Such data can be used to examine the determinants of sex differences. Methods We analysed data on respondents 18 years and over from the World Health Surveys 2002–04 in 59 countries, which included multiple measures of self-reported health, eight domains of functioning and presumptive diagnoses of chronic conditions. The age-standardized female excess fraction was computed for all indicators and analysed for five regional groups of countries. Multivariate regression models were used to examine the association between country gaps in self-reported health between the sexes with societal and other background characteristics. Results Women reported significantly poorer health than men on all self-reported health indicators. The excess fraction was 15 % for the health score based on the eight domains, 28 % for “poor” or “very poor” self-rated health on the single question, and 26 % for “severe” or “extreme” on a single question on limitations. The excess female reporting of poorer health occurred at all ages, but was smaller at ages 60 and over. The female excess was observed in all regions, and was smallest in the European high-income countries. Women more frequently reported problems in specific health domains, with the excess fraction ranging from 25 % for vision to 35 % for mobility, pain and sleep, and with considerable variation between regions. Angina, arthritis and depression had female excess fractions of 33, 32 and 42 % respectively. Higher female prevalence of the presumptive diagnoses was observed in all regional country groups. The main factors affecting the size of the gender gap in self-reported health were the female-male gaps in the prevalence of chronic conditions, especially arthritis and depression and

  16. A global assessment of the gender gap in self-reported health with survey data from 59 countries.

    Science.gov (United States)

    Boerma, Ties; Hosseinpoor, Ahmad Reza; Verdes, Emese; Chatterji, Somnath

    2016-07-30

    While surveys in high-income countries show that women generally have poorer self-reported health than men, much less is known about gender differences in other regions of the world. Such data can be used to examine the determinants of sex differences. We analysed data on respondents 18 years and over from the World Health Surveys 2002-04 in 59 countries, which included multiple measures of self-reported health, eight domains of functioning and presumptive diagnoses of chronic conditions. The age-standardized female excess fraction was computed for all indicators and analysed for five regional groups of countries. Multivariate regression models were used to examine the association between country gaps in self-reported health between the sexes with societal and other background characteristics. Women reported significantly poorer health than men on all self-reported health indicators. The excess fraction was 15 % for the health score based on the eight domains, 28 % for "poor" or "very poor" self-rated health on the single question, and 26 % for "severe" or "extreme" on a single question on limitations. The excess female reporting of poorer health occurred at all ages, but was smaller at ages 60 and over. The female excess was observed in all regions, and was smallest in the European high-income countries. Women more frequently reported problems in specific health domains, with the excess fraction ranging from 25 % for vision to 35 % for mobility, pain and sleep, and with considerable variation between regions. Angina, arthritis and depression had female excess fractions of 33, 32 and 42 % respectively. Higher female prevalence of the presumptive diagnoses was observed in all regional country groups. The main factors affecting the size of the gender gap in self-reported health were the female-male gaps in the prevalence of chronic conditions, especially arthritis and depression and gender characteristics of the society. Large female-male differences in self

  17. The maturation of auditory responses in infants and young children: a cross-sectional study from 6 to 59 months

    Directory of Open Access Journals (Sweden)

    James Christopher eEdgar

    2015-10-01

    Full Text Available Background: An understanding of the maturation of auditory cortex responses in typically developing infants and toddlers is needed to later identify auditory processing abnormalities in infants at risk for neurodevelopmental disorders. The availability of infant and young child magnetoencephalography (MEG systems may now provide near optimal assessment of left and right hemisphere auditory neuromagnetic responses in young populations. To assess the performance of a novel whole-head infant MEG system, a cross-sectional study examined the maturation of left and right auditory cortex responses in children 6- to 50-months of age. Methods: Blocks of 1000Hz (1st and 3rd blocks and 500Hz tones (2nd block were presented while MEG data were recorded using an infant/young child biomagnetometer (Artemis 123. Data were obtained from 29 children (11 males; 6 months to 59 months. Latency measures were obtained for the first positive-to-negative evoked response waveform complex in each hemisphere. Latency and age associations as well as frequency and hemisphere latency differences were examined. For the 1000 Hz tone, measures of reliability were computed. Results: For the first response - a response with a ‘P2m’ topography - latencies decreased as a function of age. For the second response - a response with a ‘N2m’ topography - no N2m latency and age relationships were observed. A main effect of tone frequency showed earlier P2m responses for 1st 1000 Hz (150 ms and 2nd 1000 Hz (148 ms versus 500 Hz tones (162 ms. A significant main effect of hemisphere showed earlier N2m responses for 2nd 1000 Hz (226 ms versus 1st 1000 Hz (241 ms versus 500 Hz tones (265 ms. P2m and N2m interclass correlation coefficient latency findings were as follows: left P2m (0.72, p < 0.001, right P2m (0.84, p < 0.001, left N2m (0.77, p < 0.001, and right N2m (0.77, p < 0.01.Conclusions: Findings of strong age and latency associations, sensitivity to tone frequency, and good

  18. Internet remote control of pump settings for postoperative continuous peripheral nerve blocks: a feasibility study in 59 patients.

    Science.gov (United States)

    Macaire, P; Nadhari, M; Greiss, H; Godwin, A; Elhanfi, O; Sainudeen, S; Abdul, M; Capdevila, X

    2014-01-01

    During continuous peripheral nerve blocks, infusion adjustments are essential for postoperative analgesia without side effects. Beside, physicians and nurse visits related to pump's settings and monitoring are time consuming and costly. We hypothesized that a remote control of pump's settings, by telemedicine transmission, adjusted to patients' feedbacks, is feasible and interesting in optimizing patient's postoperative pain management. Fifty-nine ASA physical status I and II patients were included. Ropivacaine 0.2% was infused during 72 h in CPNB catheters. After returning to the surgical ward, the patient was allowed to answer a 10 indicators questionnaire 3 times a day (8.00 AM, 2.00 PM, 8.00 PM), or unlimited on patient's demand. This information was transmitted from the pump to a server through the Internet. If one indicator was out of the predefined thresholds, the anesthesiologist in charge was immediately informed by texto on his cell phone. The anesthesiologist connected to the website, checked the data from the patient and modified the settings of the pump by remote control according to a written protocol. The changes need a secure access with a password and a confirmation. The number of settings changes, the time to realize the procedure and the adverse events related to the technique were noted. When the catheter was removed, the pump was unassigned to the patient and the data archived. Thirty sciatic, 24 femoral and 5 interscalene catheters were inserted in 59 patients. Five catheters were accidentally removed before the end of the 72-h period. The median VAS pain values at rest and during movement were respectively at 2 and 3. Sixteen patients complained about numbness promoting 2 (0-3) changes in pump settings; 9 about motor blockade with 1 (0-2) change; 5 about difficulties for physiotherapy with 1 (0-3) change. The mean time of pump settings modification after response to questionnaire or voluntarily patient's alert was 15 ± 2.2 minutes. Early

  19. Endoscopic mucosal resection for proximal superficial lesions: efficacy and safety study in 59 consecutive resections Resección endoscópica mucosa de lesiones superficiales altas: estudio de su eficacia y seguridad en 59 resecciones consecutivas

    Directory of Open Access Journals (Sweden)

    Eduardo Albéniz-Arbizu

    2012-09-01

    superficiales del tracto digestivo. Objetivos: evaluar la eficacia y seguridad de dicho procedimiento en el tracto digestivo superior. Material y métodos: se incluyeron en nuestro estudio 41 pacientes consecutivos (23 hombres y 18 mujeres, edad media de 60,6 años a los que se les realizaron 59 resecciones en 69 sesiones. Se trataron las siguientes patologías: lesiones sobreelevadas con displasia de alto grado sobre esófago de Barrett (grupo A, displasia de alto grado en biopsias aleatorias del seguimiento de esófago de Barrett (grupo B y lesiones superficiales gastroduodenales (grupo C. Las técnicas utilizadas fueron la resección con asa tras inyección submucosa, la asistida por bandas o por capuchón. Resultados: se resecaron 7 lesiones sobreelevadas con displasia de alto grado sobre esófago de Barrett, 6 esófagos de Barrett con displasia de alto grado de forma completa en 16 sesiones secuenciales de resección mucosa y 46 lesiones superficiales gastroduodenales (10 adenomas, 9 carcinomas gástricos superficiales, 18 carcinoides y 9 lesiones de diferente estirpe. Las resecciones se realizaron con éxito en el 100% de los dos primeros grupos y en el 97,9% del grupo C. Como complicaciones tuvimos 2 sangrados diferidos autolimitados (grupos A y B y dos casos de estenosis con escasa relevancia clínica en el grupo B. Conclusiones: a la resección endoscópica mucosa es una técnica eficaz en el tratamiento de lesiones superficiales del tracto digestivo superior; b se trata de un procedimiento seguro, con un porcentaje de complicaciones muy bajo y que generalmente pueden ser manejadas de forma endoscópica; y c al contrario que otras técnicas ablativas, permite el estudio anatomopatológico de las muestras.

  20. Inhibition of Atg6 and Pi3K59F autophagy genes in neurons decreases lifespan and locomotor ability in Drosophila melanogaster.

    Science.gov (United States)

    M'Angale, P G; Staveley, B E

    2016-10-24

    Autophagy is a cellular mechanism implicated in the pathology of Parkinson's disease. The proteins Atg6 (Beclin 1) and Pi3K59F are involved in autophagosome formation, a key step in the initiation of autophagy. We first used the GMR-Gal4 driver to determine the effect of reducing the expression of the genes encoding these proteins on the developing Drosophila melanogaster eye. Subsequently, we inhibited their expression in D. melanogaster neurons under the direction of a Dopa decarboxylase (Ddc) transgene, and examined the effects on longevity and motor function. Decreased longevity coupled with an age-dependent loss of climbing ability was observed. In addition, we investigated the roles of these genes in the well-studied α-synuclein-induced Drosophila model of Parkinson's disease. In this context, lowered expression of Atg6 or Pi3K59F in Ddc-Gal4-expressing neurons results in decreased longevity and associated age-dependent loss of locomotor ability. Inhibition of Atg6 or Pi3K59F together with overexpression of the sole pro-survival Bcl-2 Drosophila homolog Buffy in Ddc-Gal4-expressing neurons resulted in further decrease in the survival and climbing ability of Atg6-RNAi flies, whereas these measures were ameliorated in Pi3K59F-RNAi flies.

  1. 2017-10-08T20:59:55Z https://www.ajol.info/index.php/all/oai oai:ojs ...

    African Journals Online (AJOL)

    article/101259 2017-10-08T20:59:55Z ijbcs:ART Exposure to cigarette smoke altered the cytoarchitecture and anti-oxidant activity of the frontal cortex in Wistar rats Omotoso, GO Kadir, RE Alabi, JT Alabi, AS Oyabambi, AO This study was ...

  2. 2017-11-05T01:11:59Z https://www.ajol.info/index.php/all/oai oai:ojs ...

    African Journals Online (AJOL)

    article/15048 2017-11-05T01:11:59Z ajb:ART Evaluation of microbial systems for bioremediation of petroleum refinery effluents in Nigeria Ojumu, TV; Bioprocess Engineering Unit, University of Cape Town, Cape Town, South Africa Bello, OO; ...

  3. Induction of Antibodies and T Cell Responses by a Recombinant Influenza Virus Carrying an HIV-1 TatΔ51–59 Protein in Mice

    Directory of Open Access Journals (Sweden)

    B. Garulli

    2014-01-01

    Full Text Available Recombinant influenza viruses hold promise as vectors for vaccines to prevent transmission of mucosal pathogens. In this study, we generated a recombinant WSN/TatΔ51–59 virus in which Tat protein lacking residues 51 to 59 of the basic domain was inserted into the N-terminus of the hemagglutinin (HA of A/WSN/33 virus. The TatΔ51–59 insertion into the viral HA caused a 2-log reduction in viral titers in cell culture, compared with the parental A/WSN/33 virus, and severely affected virus replication in vivo. Nevertheless, Tat-specific antibodies and T cell responses were elicited upon a single intranasal immunization of BALB/c mice with WSN/TatΔ51–59 virus. Moreover, Tat-specific immune responses were also detected following vaccine administration via the vaginal route. These data provide further evidence that moderately large HIV antigens can be delivered by chimeric HA constructs and elicit specific immune responses, thus increasing the options for the potential use of recombinant influenza viruses, and their derivatives, for prophylactic and therapeutic vaccines.

  4. 2017-10-05T01:54:59Z https://www.ajol.info/index.php/all/oai oai:ojs ...

    African Journals Online (AJOL)

    article/22421 2017-10-05T01:54:59Z ai:ART Internet Adoption among Ghana\\'s SME Non-Traditional Exporters Hinson, Robert E; Marketing Department, University of Ghana Business School In spite of the apparent benefits of using the Internet as ...

  5. 2017-11-04T13:59:38Z https://www.ajol.info/index.php/all/oai oai:ojs ...

    African Journals Online (AJOL)

    article/35440 2017-11-04T13:59:37Z jtmb:ART The anti-viral effect of Acacia mellifera, Melia azedarach and Prunus Africana, extracts against herpes simplex virus type 1 infection in mice Tolo, FM; Kenya Medical Research Institute, P.O Box ...

  6. Efficacy of vaccination with different combinations of MF59-adjuvanted and nonadjuvanted seasonal and pandemic influenza vaccines against pandemic H1N1 influenza virus infection in ferrets

    NARCIS (Netherlands)

    J.M.A. van den Brand (Judith); J.H.C.M. Kreijtz (Joost); R. Bodewes (Rogier); K.J. Stittelaar (Koert); G. van Amerongen (Geert); T. Kuiken (Thijs); J.H. Simon (James); R.A.M. Fouchier (Ron); G. del Giudice (Giuseppe); R. Rappuoli (Rino); G.F. Rimmelzwaan (Guus); A.D.M.E. Osterhaus (Albert)

    2011-01-01

    textabstractSerum antibodies induced by seasonal influenza or seasonal influenza vaccination exhibit limited or no cross-reactivity against the 2009 pandemic swine-origin influenza virus of the H1N1 subtype (pH1N1). Ferrets immunized once or twice with MF59-adjuvanted seasonal influenza vaccine

  7. Quantitation of CD55 and CD59 expression on reticulocytes and mature erythrocytes in paroxysmal nocturnal hemoglobinuria, aplastic anemia, and healthy control subjects.

    Science.gov (United States)

    Kim, Yeongsic; Lim, Jihyang; Kim, Myungshin; Kim, Yonggoo; Lee, Jong-Wook; Han, Kyungja

    2010-01-01

    Since PNH occasionally results in bone marrow failure, it is difficult to differentiate PNH from AA with small numbers of CD(55) (-)CD(59) (-) erythrocytes. We quantified CD55 and CD59 molecules expressed on normal reticulocytes and mature erythrocytes of paroxysmal nocturnal hemoglobinuria (PNH), aplastic anemia (AA), and normal individuals in order to determine their usefulness for differentiation between PNH and AA. A total of 56 patients (AA 39 patients, PNH 17 patients) and 10 healthy volunteers were enrolled. Two-color flow cytometric analyses were conducted using thiazole orange, anti-CD55 and CD59 monoclonal antibodies to identify CD(55) (-)CD(59) (-) reticulocytes and mature erythrocytes. Mean fluorescence level of CD(55) (+) mature erythrocytes was lowest in the PNH patients (13.2 x 10(3) MESF), and was significantly lower than in normal controls (16.7 x 10(3) MESF, p erythrocytes was lowest in the PNH subjects (24.5 x 10(3) MESF), significantly less than in normal controls (39.0 x 10(3) MESF, p erythrocytes may be useful in differentiating PNH from AA patients with small numbers of PNH-phenotype erythrocytes, and the total reticulocyte count may prove useful as a marker for PNH clone size.

  8. 2017-10-31T15:59:20Z https://www.ajol.info/index.php/all/oai oai:ojs ...

    African Journals Online (AJOL)

    article/43652 2017-10-31T15:59:20Z safp:ART A Bibliometric Analysis of Research Publications Funded Partially by the Cancer Association of South Africa (CANSA) during a 10-year Period (1994-2003) Albrecht, CF bibliometric analysis; cancer ...

  9. 2017-12-10T07:42:59Z https://www.ajol.info/index.php/all/oai oai:ojs ...

    African Journals Online (AJOL)

    article/76423 2017-12-10T07:42:59Z pie:ART The public role of the university reconsidered Waghid, Y Today, higher education has become a commodity in the global education market aiming to serve the knowledge society through 'the ...

  10. Coulomb stress interactions among M≥5.9 earthquakes in the Gorda deformation zone and on the Mendocino Fracture Zone, Cascadia megathrust, and northern San Andreas fault

    Science.gov (United States)

    Rollins, John C.; Stein, Ross S.

    2010-01-01

    The Gorda deformation zone, a 50,000 km2 area of diffuse shear and rotation offshore northernmost California, has been the site of 20 M ≥ 5.9 earthquakes on four different fault orientations since 1976, including four M ≥ 7 shocks. This is the highest rate of large earthquakes in the contiguous United States. We calculate that the source faults of six recent M ≥ 5.9 earthquakes had experienced ≥0.6 bar Coulomb stress increases imparted by earthquakes that struck less than 9 months beforehand. Control tests indicate that ≥0.6 bar Coulomb stress interactions between M ≥ 5.9 earthquakes separated by Mw = 7.3 Trinidad earthquake are consistent with the locations of M ≥ 5.9 earthquakes in the Gorda zone until at least 1995, as well as earthquakes on the Mendocino Fault Zone in 1994 and 2000. Coulomb stress changes imparted by the 1980 earthquake are also consistent with its distinct elbow-shaped aftershock pattern. From these observations, we derive generalized static stress interactions among right-lateral, left-lateral and thrust faults near triple junctions.

  11. Elicited soybean (Glycine max) extract effect on improving levels of Ter-119+Cd59+ in a mouse model fed a high fat-fructose diet

    Science.gov (United States)

    Safitri, Yunita Diyah; Widyarti, Sri; Rifa'i, Muhaimin

    2017-05-01

    People who have unbalanced lifestyles and habits such as consuming high fat and sugar foods, as well as the lack of physical activity, have an increased risk of obesity and related metabolic diseases. The condition of obesity occurs due to an excess of nutrients which leads to low-grade inflammation. Inflammation induced by obesity causes unstable bone marrow homeostasis which is associated with proliferation and differentiation of Hematopoietic Stem Cells (HSCs). This study aimed to observe the erythroid progenitor (TER-119) and complement regulator (CD59) on bone marrow cells in mouse models fed a high fat-fructose diet (HFFD). This research was conducted by modeling obese mice using high fat and fructose food for 20 weeks, and then treating them with elicited soybean extract (ESE) for four weeks with several doses: low dose (78 mg/kgBB), moderate dose (104 mg/kgBB) and high dose (130 mg/kgBB). Cell TER119+CD59+ expression decreased in the HFFD group compared to the normal group. In the low, moderate and high dose group, TER119+CD59+ expression significantly increased compared to the HFFD group. These results demonstrate that soybean elicited extract can improve the hematopoietic system by increasing TER119+CD59+ expression in a high fat and fructose diet mouse model.

  12. Acute Uncomplicated Febrile Illness in Children Aged 2-59 months in Zanzibar - Aetiologies, Antibiotic Treatment and Outcome.

    Directory of Open Access Journals (Sweden)

    Kristina Elfving

    Full Text Available Despite the fact that a large proportion of children with fever in Africa present at primary health care facilities, few studies have been designed to specifically study the causes of uncomplicated childhood febrile illness at this level of care, especially in areas like Zanzibar that has recently undergone a dramatic change from high to low malaria transmission.We prospectively studied the aetiology of febrile illness in 677 children aged 2-59 months with acute uncomplicated fever managed by IMCI (Integrated Management of Childhood Illness guidelines in Zanzibar, using point-of-care tests, urine culture, blood-PCR, chest X-ray (CXR of IMCI-pneumonia classified patients, and multiple quantitative (qPCR investigations of nasopharyngeal (NPH (all patients and rectal (GE swabs (diarrhoea patients. For comparison, we also performed NPH and GE qPCR analyses in 167 healthy community controls. Final fever diagnoses were retrospectively established based on all clinical and laboratory data. Clinical outcome was assessed during a 14-day follow-up. The utility of IMCI for identifying infections presumed to require antibiotics was evaluated.NPH-qPCR and GE-qPCR detected ≥1 pathogen in 657/672 (98% and 153/164 (93% of patients and 158/166 (95% and 144/165 (87% of controls, respectively. Overall, 57% (387/677 had IMCI-pneumonia, but only 12% (42/342 had CXR-confirmed pneumonia. Two patients were positive for Plasmodium falciparum. Respiratory syncytial virus (24.5%, influenza A/B (22.3%, rhinovirus (10.5% and group-A streptococci (6.4%, CXR-confirmed pneumonia (6.2%, Shigella (4.3% were the most common viral and bacterial fever diagnoses, respectively. Blood-PCR conducted in a sub-group of patients (n = 83 without defined fever diagnosis was negative for rickettsiae, chikungunya, dengue, Rift Valley fever and West Nile viruses. Antibiotics were prescribed to 500 (74% patients, but only 152 (22% had an infection retrospectively considered to require

  13. Activation of the dormant secondary metabolite production by introducing gentamicin-resistance in a marine-derived Penicillium purpurogenum G59.

    Science.gov (United States)

    Chai, Yun-Jing; Cui, Cheng-Bin; Li, Chang-Wei; Wu, Chang-Jing; Tian, Cong-Kui; Hua, Wei

    2012-03-01

    A new approach to activate silent gene clusters for dormant secondary metabolite production has been developed by introducing gentamicin-resistance to an originally inactive, marine-derived fungal strain Penicillium purpurogenum G59. Upon treatment of the G59 spores with a high concentration of gentamicin in aqueous DMSO, a total of 181 mutants were obtained by single colony isolation. In contrast to the strain G59, the EtOAc extracts of nine mutant cultures showed inhibitory effects on K562 cells, indicating that the nine mutants had acquired capability to produce antitumor metabolites. This was evidenced by TLC and HPLC analysis of EtOAc extracts of G59 and the nine mutants. Further isolation and characterization demonstrated that four antitumor secondary metabolites, janthinone (1), fructigenine A (2), aspterric acid methyl ester (3) and citrinin (4), were newly produced by mutant 5-1-4 compared to the parent strain G59, and which were also not found in the secondary metabolites of other Penicillium purpurogenum strains. However, Compounds 1-4 inhibited the proliferation of K562 cells with inhibition rates of 34.6% (1), 60.8% (2), 31.7% (3) and 67.1% (4) at 100 μg/mL, respectively. The present study demonstrated the effectiveness of a simple, yet practical approach to activate the production of dormant fungal secondary metabolites by introducing acquired resistance to aminoglycoside antibiotics, which could be applied to the studies for eliciting dormant metabolic potential of fungi to obtain cryptic secondary metabolites.

  14. MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action.

    Science.gov (United States)

    Caproni, Elena; Tritto, Elaine; Cortese, Mario; Muzzi, Alessandro; Mosca, Flaviana; Monaci, Elisabetta; Baudner, Barbara; Seubert, Anja; De Gregorio, Ennio

    2012-04-01

    The innate immune pathways induced by adjuvants required to increase adaptive responses to influenza subunit vaccines are not well characterized. We profiled different TLR-independent (MF59 and alum) and TLR-dependent (CpG, resiquimod, and Pam3CSK4) adjuvants for the ability to increase the immunogenicity to a trivalent influenza seasonal subunit vaccine and to tetanus toxoid (TT) in mouse. Although all adjuvants boosted the Ab responses to TT, only MF59 and Pam3CSK4 were able to enhance hemagglutinin Ab responses. To identify innate immune correlates of adjuvanticity to influenza subunit vaccine, we investigated the gene signatures induced by each adjuvant in vitro in splenocytes and in vivo in muscle and lymph nodes using DNA microarrays. We found that flu adjuvanticity correlates with the upregulation of proinflammatory genes and other genes involved in leukocyte transendothelial migration at the vaccine injection site. Confocal and FACS analysis confirmed that MF59 and Pam3CSK4 were the strongest inducers of blood cell recruitment in the muscle compared with the other adjuvants tested. Even though it has been proposed that IFN type I is required for adjuvanticity to influenza vaccines, we found that MF59 and Pam3CSK4 were not good inducers of IFN-related innate immunity pathways. By contrast, resiquimod failed to enhance the adaptive response to flu despite a strong activation of the IFN pathway in muscle and lymph nodes. By blocking IFN type I receptor through a mAb, we confirmed that the adjuvanticity of MF59 and Pam3CSK4 to a trivalent influenza vaccine and to TT is IFN independent.

  15. Safety and immunogenicity of an MF59-adjuvanted A/H1N1 pandemic influenza vaccine in children from three to seventeen years of age.

    Science.gov (United States)

    Knuf, Markus; Leroux-Roels, Geert; Rümke, Hans C; Abarca, Katia; Rivera, Luis; Lattanzi, Maria; Pedotti, Paola; Arora, Ashwani; Kieninger-Baum, Dorothee; Della Cioppa, Giovanni

    2015-01-01

    This study was designed to identify the optimal dose of an MF59-adjuvanted, monovalent, A/H1N1 influenza vaccine in healthy paediatric subjects. Subjects aged 3-8 years (n=194) and 9-17 years (n=160) were randomized to receive two primary doses of A/H1N1 vaccine containing either 3.75 μg antigen with half a standard dose of MF59 adjuvant, 7.5 μg antigen with a full dose of MF59, or (children 3-8 years only), a non-adjuvanted 15 μg formulation. A booster dose of MF59-adjuvanted seasonal influenza vaccine including homologous A/H1N1 strain was given one year after priming. Immunogenicity was assessed by haemagglutination inhibition (HI) and microneutralization assays. Vaccine safety was assessed throughout the study (up to 18 months). A single priming dose of either MF59-adjuvanted formulation was sufficient to meet the European licensure criteria for pandemic influenza vaccines (HI titres ≥1:40>70%; seroconversion>40%; and GMR>2.5). Two non-adjuvanted vaccine doses were required to meet the same licensure criteria. After first and second doses, percentage of subjects with HI titres ≥1:40 were between 97% and 100% in the adjuvanted vaccine groups compared with 68% and 91% in the non-adjuvanted group, respectively. Postvaccination seroconversion rates ranged from 91% to 98% in adjuvanted groups and were 68% (first dose) and 98% (second dose) in the non-adjuvanted group. HI titres ≥1:330 after primary doses were achieved in 69% to 90% in adjuvanted groups compared with 41% in the non-adjuvanted group. Long-term antibody persistence after priming and a robust antibody response to booster immunization were observed in all vaccination groups. All A/H1N1 vaccine formulations were generally well tolerated. No vaccine-related serious adverse events occurred, and no subjects were withdrawn from the study due to an adverse event. An MF59-adjuvanted influenza vaccine containing 3.75 μg of A/H1N1 antigen was well tolerated and sufficiently immunogenic to meet all the

  16. Ferromagnetic critical behavior in U(Co1-xFex)Al (0 ≤x ≤0.02 ) studied by 59Co nuclear quadrupole resonance measurements

    Science.gov (United States)

    Karube, K.; Hattori, T.; Ishida, K.; Kimura, N.

    2015-02-01

    In order to investigate physical properties around a ferromagnetic (FM) quantum transition point and a tricritical point (TCP) in the itinerant-electron metamagnetic compound UCoAl, we have performed the 59Co nuclear quadrupole resonance (NQR) measurement for the Fe-substituted U(Co1-xFex)Al(x =0 ,0.5 ,1 ,and2 %) in zero external magnetic field. The Fe concentration dependence of 59Co -NQR spectra at low temperatures indicates that the first-order FM transition occurs at least above x =1 % . The magnetic fluctuations along the c axis detected by the nuclear spin-spin relaxation rate 1 /T2 exhibit an anomaly at Tmax˜20 K and enhance with increasing x . These results are in good agreement with theoretical predictions and indicate the presence of prominent critical fluctuations at the TCP in this system.

  17. A Caprine Herpesvirus 1 Vaccine Adjuvanted with MF59™ Protects against Vaginal Infection and Interferes with the Establishment of Latency in Goats

    Science.gov (United States)

    Marinaro, Mariarosaria; Rezza, Giovanni; Del Giudice, Giuseppe; Colao, Valeriana; Tarsitano, Elvira; Camero, Michele; Losurdo, Michele; Buonavoglia, Canio; Tempesta, Maria

    2012-01-01

    The immunogenicity and the efficacy of a beta-propiolactone-inactivated caprine herpesvirus 1 (CpHV-1) vaccine adjuvanted with MF59™ were tested in goats. Following two subcutaneous immunizations, goats developed high titers of CpHV-1-specific serum and vaginal IgG and high serum virus neutralization (VN) titers. Peripheral blood mononuclear cells (PBMC) stimulated in vitro with inactivated CpHV-1 produced high levels of soluble IFN-gamma and exhibited high frequencies of IFN-gamma producing cells while soluble IL-4 was undetectable. On the other hand, control goats receiving the inactivated CpHV-1 vaccine without adjuvant produced only low serum antibody responses. A vaginal challenge with virulent CpHV-1 was performed in all vaccinated goats and in naïve goats to assess the efficacy of the two vaccines. Vaginal disease was not detected in goats vaccinated with inactivated CpHV-1 plus MF59™ and these animals had undetectable levels of infectious challenge virus in their vaginal washes. Goats vaccinated with inactivated CpHV-1 in the absence of adjuvant exhibited a less severe disease when compared to naïve goats but shed titers of challenge virus that were similar to those of naïve goats. Detection and quantitation of latent CpHV-1 DNA in sacral ganglia in challenged goats revealed that the inactivated CpHV-1 plus MF59™ vaccine was able to significantly reduce the latent viral load when compared either to the naïve goats or to the goats vaccinated with inactivated CpHV-1 in the absence of adjuvant. Thus, a vaccine composed of inactivated CpHV-1 plus MF59™ as adjuvant was strongly immunogenic and induced effective immunity against vaginal CpHV-1 infection in goats. PMID:22511971

  18. Chemical consequences of the nuclear reactions 58Fe(n,γ)59Fe and 57Co(EC)57Fe in soluble Prussian Blue

    DEFF Research Database (Denmark)

    Fenger, Jes; Maddock, A. G.; Siekierska, K. E.

    1970-01-01

    KFe[Fe(CN)6],H2O was prepared with 58Fe in either the cation or the complex, and both samples were neutron-irradiated and analysed for free and complexed 59Fe. Parallel experiments were performed on K4[Fe(CN)6],3H2O. In Prussian Blue the retention in the hexacyano-complex is ca. 5% and can be inc...

  19. Urinary alpha-1 antitrypsin and CD59 glycoprotein predict albuminuria development in hypertensive patients under chronic renin-angiotensin system suppression.

    Science.gov (United States)

    Gonzalez-Calero, Laura; Martin-Lorenzo, Marta; de la Cuesta, Fernando; Maroto, Aroa S; Baldan-Martin, Montserrat; Ruiz-Hurtado, Gema; Pulido-Olmo, Helena; Segura, Julian; Barderas, Maria G; Ruilope, Luis M; Vivanco, Fernando; Alvarez-Llamas, Gloria

    2016-01-16

    Hypertension is a multi-factorial disease of increasing prevalence and a major risk factor for cardiovascular mortality even in the presence of adequate treatment. Progression of cardiovascular disease (CVD) occurs frequently during chronic renin-angiotensin-system (RAS) suppression, and albuminuria is a marker of CV risk. High prevalence of albuminuria in treated hypertensive patients has been demonstrated, but there are no available markers able to predict evolution. The aim of this study was the identification of novel indicators of albuminuria progression measurable in urine of diabetic and non-diabetic patients. 1143 hypertensive patients under chronic treatment were followed for a minimum period of 3 years. Among them, 105 diabetic and non-diabetic patients were selected and classified in three groups according to albuminuria development during follow-up: (a) patients with persistent normoalbuminuria; (b) patients developing de novo albuminuria; (c) patients with maintained albuminuria. Differential urine analysis was performed by 2D gel electrophoresis (2D-DIGE) and further confirmed by liquid chromatography-mass spectrometry. Non-parametric statistical tests were applied. CD59 glycoprotein and alpha-1 antitrypsin (AAT) resulted already altered in patients developing albuminuria de novo, with a similar response in those with maintained albuminuria. A prospective study in a sub-group of normoalbuminuric patients who were clinically followed up for at least 1 year from urine sampling, revealed CD59 and AAT proteins significantly varied in the urine collected from normoalbuminurics who will negatively progress, serving as predictors of future albuminuria development. CD59 and AAT proteins are significantly altered in hypertensive patients developing albuminuria. Interestingly, CD59 and AAT are able to predict, in normoalbuminuric individuals, who will develop albuminuria in the future, being potential predictors of vascular damage and CV risk. These findings

  20. Distribution of /sup 51/Cr, /sup 54/Mn, /sup 59/Fe, /sup 60/Co, /sup 109/Cd and /sup 124/Sb in organs of lactating cows

    Energy Technology Data Exchange (ETDEWEB)

    Bruwaene, R. van; Kirchmann, R.; Gerber, G.B.; Colard, J.; Vankerkom, J. (Centre d' Etude de l' Energie Nucleaire, Mol (Belgium))

    1983-05-01

    Lactating cows were given /sup 51/Cr, /sup 54/Mn, /sup 59/Fe, /sup 60/Co, /sup 109/Cd and /sup 124/Sb together with maize silage. The animals were slaughtered 97 days later and the distribution of the isotopes in the body was determined. With some notable exceptions, the isotopes accumulated in the large parenchymal organs (liver, kidney and spleen), but substantial amounts, particularly of cadmium and chromium, were also found in the intestine. Manganese concentrated in the pancreas and brain.

  1. Incidence of narcolepsy before and after MF59-adjuvanted influenza A(H1N1)pdm09 vaccination in South Korean soldiers.

    Science.gov (United States)

    Kim, Woo Jung; Lee, Sang Don; Lee, Eun; Namkoong, Kee; Choe, Kang-Won; Song, Joon Young; Cheong, Hee Jin; Jeong, Hye Won; Heo, Jung Yeon

    2015-09-11

    Previous reports mostly from Europe suggested an association between an occurrence of narcolepsy and an influenza A(H1N1)pdm09 vaccine adjuvanted with AS03 (Pandemrix(®)). During the 2009 H1N1 pandemic vaccination campaign, the Korean military performed a vaccination campaign with one type of influenza vaccine containing MF59-adjuvants. This study was conducted to investigate the background incidence rate of narcolepsy in South Korean soldiers and the association of the MF59-adjuvanted vaccine with the occurrence of narcolepsy in a young adult group. To assess the incidence of narcolepsy, we retrospectively reviewed medical records of suspicious cases of narcolepsy in 2007-2013 in the whole 20 military hospitals of the Korean military. The screened cases were classified according to the Brighton Collaboration case definition of narcolepsy. After obtaining the number of confirmed cases of narcolepsy per 3 months in 2007-2013, we compared the crude incidence rate of narcolepsy before and after the vaccination campaign. We included 218 narcolepsy suspicious cases in the initial review, which were screened by the diagnostic code on the computerized disease registry in 2007-2013. Forty-one cases were finally diagnosed with narcolepsy in 2007-2013 (male sex, 95%; median age, 21 years). The average background incidence rate of narcolepsy in Korean soldiers was 0.91 cases per 100,000 persons per year. During the 9 months before vaccination implementation (April to December 2009), 6 narcolepsy cases occurred, whereas during the next 9 months (January to September 2010) including the 3-month vaccination campaign, 5 cases occurred. The incidence of narcolepsy in South Korean soldiers was not increased after the pandemic vaccination campaign using the MF59-adjuvanted vaccine. Our results suggest that the MF59-adjuvanted H1N1 vaccine did not contribute to the occurrence of narcolepsy in this young adult group. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. ¹H, ¹⁵N, and ¹³C backbone chemical shift assignment of titin domains A59-A60 and A60 alone.

    Science.gov (United States)

    Czajlik, András; Thompson, Gary S; Khan, Ghulam N; Kalverda, Arnout P; Homans, Steve W; Trinick, John

    2014-10-01

    The giant protein titin is the third most abundant protein of vertebrate striated muscle. The titin molecule is >1 μm long and spans half the sarcomere, from the Z-disk to the M-line, and has important roles in sarcomere assembly, elasticity and intracellular signaling. In the A-band of the sarcomere titin is attached to the thick filaments and mainly consists immunoglobulin-like and fibronectin type III-like domains. These are mostly arranged in long-range patterns or 'super-repeats'. The large super-repeats each contain 11 domains and are repeated 11 times, thus forming nearly half the titin molecule. Through interactions with myosin and C-protein, they are involved in thick filament assembly. The importance of titin in muscle assembly is highlighted by the effect of mutations in the A-band portion, which are the commonest cause of dilated cardiomyopathy, affecting ~1 in 250 (Herman et al. in N Engl J Med 366:619-628, 2012). Here we report backbone (15)N, (13)C and (1)H chemical shift and (13)Cβ assignments for the A59-A60 domain tandem from the titin A59-A69 large super-repeat, completed using triple resonance NMR. Since, some regions of the backbone remained unassigned in A60 domain of the complete A59-A60 tandem, a construct containing a single A60 domain, A60sd, was also studied using the same methods. Considerably improved assignment coverage was achieved using A60sd due to its lower mass and improved molecular tumbling rate; these assignments also allowed the analysis of inter-domain interactions using chemical shift mapping against A59-A60.

  3. Anemia and Micronutrient Status of Women of Childbearing Age and Children 6-59 Months in the Democratic Republic of the Congo.

    Science.gov (United States)

    Harvey-Leeson, Sarah; Karakochuk, Crystal D; Hawes, Meaghan; Tugirimana, Pierrot L; Bahizire, Esto; Akilimali, Pierre Z; Michaux, Kristina D; Lynd, Larry D; Whitfield, Kyly C; Moursi, Mourad; Boy, Erick; Foley, Jennifer; McLean, Judy; Houghton, Lisa A; Gibson, Rosalind S; Green, Tim J

    2016-02-17

    Little is known about the micronutrient status of women and children in the Democratic Republic of the Congo, which is critical for the design of effective nutrition interventions. We recruited 744 mother-child pairs from South Kivu (SK) and Kongo Central (KC). We determined hemoglobin (Hb), serum zinc, vitamin B12, folate, ferritin, soluble transferrin receptor (sTfR), retinol binding protein (RBP), C-reactive protein, and α-1 acid glycoprotein concentrations. Anemia prevalence was determined using Hb adjusted for altitude alone and Hb adjusted for both altitude and ethnicity. Anemia prevalence was lower after Hb adjustment for altitude and ethnicity, compared to only altitude, among women (6% vs. 17% in SK; 10% vs. 32% in KC), children 6-23 months (26% vs. 59% in SK; 25% vs. 42% in KC), and children 24-59 months (14% vs. 35% in SK; 23% vs. 44% in KC), respectively. Iron deficiency was seemingly higher with sTfR as compared to inflammation-adjusted ferritin among women (18% vs. 4% in SK; 21% vs. 5% in KC), children 6-23 months (51% vs. 14% in SK; 74% vs. 10% in KC), and children 24-59 months (23% vs. 4% in SK; 58% vs. 1% in KC). Regardless of indicator, iron deficiency anemia (IDA) never exceeded 3% in women. In children, IDA reached almost 20% when sTfR was used but was only 10% with ferritin. Folate, B12, and vitamin A (RBP) deficiencies were all very low (children. The prevalence of anemia was unexpectedly low. Inflammation-adjusted zinc deficiency was high among women (52% in SK; 58% in KC), children 6-23 months (23% in SK; 20% in KC), and children 24-59 months (25% in SK; 27% in KC). The rate of biochemical zinc deficiency among Congolese women and children requires attention.

  4. Anemia and Micronutrient Status of Women of Childbearing Age and Children 6–59 Months in the Democratic Republic of the Congo

    Science.gov (United States)

    Harvey-Leeson, Sarah; Karakochuk, Crystal D.; Hawes, Meaghan; Tugirimana, Pierrot L.; Bahizire, Esto; Akilimali, Pierre Z.; Michaux, Kristina D.; Lynd, Larry D.; Whitfield, Kyly C.; Moursi, Mourad; Boy, Erick; Foley, Jennifer; McLean, Judy; Houghton, Lisa A.; Gibson, Rosalind S.; Green, Tim J.

    2016-01-01

    Little is known about the micronutrient status of women and children in the Democratic Republic of the Congo, which is critical for the design of effective nutrition interventions. We recruited 744 mother-child pairs from South Kivu (SK) and Kongo Central (KC). We determined hemoglobin (Hb), serum zinc, vitamin B12, folate, ferritin, soluble transferrin receptor (sTfR), retinol binding protein (RBP), C-reactive protein, and α-1 acid glycoprotein concentrations. Anemia prevalence was determined using Hb adjusted for altitude alone and Hb adjusted for both altitude and ethnicity. Anemia prevalence was lower after Hb adjustment for altitude and ethnicity, compared to only altitude, among women (6% vs. 17% in SK; 10% vs. 32% in KC), children 6–23 months (26% vs. 59% in SK; 25% vs. 42% in KC), and children 24–59 months (14% vs. 35% in SK; 23% vs. 44% in KC), respectively. Iron deficiency was seemingly higher with sTfR as compared to inflammation-adjusted ferritin among women (18% vs. 4% in SK; 21% vs. 5% in KC), children 6–23 months (51% vs. 14% in SK; 74% vs. 10% in KC), and children 24–59 months (23% vs. 4% in SK; 58% vs. 1% in KC). Regardless of indicator, iron deficiency anemia (IDA) never exceeded 3% in women. In children, IDA reached almost 20% when sTfR was used but was only 10% with ferritin. Folate, B12, and vitamin A (RBP) deficiencies were all very low (children. The prevalence of anemia was unexpectedly low. Inflammation-adjusted zinc deficiency was high among women (52% in SK; 58% in KC), children 6–23 months (23% in SK; 20% in KC), and children 24–59 months (25% in SK; 27% in KC). The rate of biochemical zinc deficiency among Congolese women and children requires attention. PMID:26901219

  5. Children aged 12–59 months missed through the National Vitamin A Capsule Distribution Program in Bangladesh: findings of the Nutritional Surveillance Project

    OpenAIRE

    Akhter, N.; Witten, C.; Stallkamp, G.; Anderson, V.; Pee, S. de; Haselow, N.

    2009-01-01

    From January 1990 to December 2006, Helen Keller International implemented the Nutritional Surveillance Project (NSP) in Bangladesh, which has been used to conduct regular surveillance and special surveys to provide information on health and nutritional status of children and mothers, and report on the coverage and impact of nutrition and health programs in Bangladesh. The Government of Bangladesh (GOB) distributes vitamin A Capsule (VAC) among children aged 12–59 months biannually. The NSP d...

  6. Carboxymethyl chitosan nanoparticles coupled with CD59-specific ligand peptide for targeted delivery of C-phycocyanin to HeLa cells.

    Science.gov (United States)

    Yang, Peng; Li, Bing; Yin, Qi-Feng; Wang, Yu-Juan

    2017-03-01

    The combination of nanotechnology and medicine will be the next generation of vehicles for targeted drug delivery. Carboxymethyl chitosan loaded with the anticancer drug C-phycocyanin and the CD59-specific ligand peptide for cancer cell targeting were used to create C-phycocyanin/carboxymethyl chitosan-CD59-specific ligand peptide nanoparticles using the ionic-gelation method. Optimal synthesis conditions, selected by response surface methodology, comprised the ratio carboxymethyl chitosan:C-phycocyanin = 3:1, and carboxymethyl chitosan and CaCl2 concentrations of 2.0 and 1.0 mg/mL, respectively. The resulting nanoparticles were spherical, with diameters of approximately 200 nm; the entrapment efficient was about 65%; and the drug loading was about 20%. The release of C-phycocyanin from C-phycocyanin/carboxymethyl chitosan nanoparticles was pH sensitive and had a sustainable effect in vitro. Guided by the CD59-specific ligand peptide, the nanoparticles efficiently targeted the surface of HeLa cells and had an obvious inhibitory effect on HeLa cell proliferation as determined by methyl thiazolyl tetrazolium assays. The nanoparticles were hemocompatible and induced apoptosis by upregulation of cleaved caspase-3 and cleaved polyADP-ribose polymerase proteins, and downregulation of Bcl-2 proteins. Our study provides a novel approach to the research and development of marine drugs, and support for targeted therapy using anticancer drugs.

  7. Positive iodine-131 6 beta-iodomethyl-19-norcholesterol (NP-59) adrenal images can precede return of adrenocortical function after o,p' DDD treatment

    Energy Technology Data Exchange (ETDEWEB)

    Sparagana, M.; Ackerman, L.

    1988-05-01

    A patient with bilateral adrenal hyperplasia, due to the ectopic adrenocorticotrophic hormone (ACTH) syndrome, received a 3-month course of treatment with 1,1 dichloro-2(o-chlorophenyl)-2-(p-chlorophenyl)ethane (o,p' DDD), which caused adrenal hypofunction requiring steroid therapy. Eleven months later, Cushing's syndrome recurred. His CT scan showed a left adrenal gland that was enlarged and a normal-sized right adrenal gland. However, the NP-59 image showed increased uptake by both glands. Venous effluent was sampled from each adrenal vein. The plasma cortisol level from the left gland was 1392 ng/ml, and that from the right gland was 667 ng/ml. The latter value was not significantly different from the values obtained at peripheral sites (517-744 ng/ml). In the course of recovery from o,p' DDD damage, the ability of the adrenal gland to take up NP-59 may be restored before the return of its biosynthetic and secretory functions. Serial NP-59 adrenal images can anticipate the recurrence of Cushing's syndrome after adrenolytic therapy, thereby permitting early retreatment.

  8. The effects of marathon running on expression of the complement regulatory proteins CD55 (DAF) and CD59 (MACIF) on red blood cells.

    Science.gov (United States)

    Simpson, Richard J; Florida-James, Geraint D; Whyte, Greg P; Middleton, Natalie; Shave, Rob; George, Keith; Guy, Keith

    2007-01-01

    Exercise is known to result in the haemolysis of red blood cells (RBCs). Although mechanical stressors such as footstrike and an increased velocity of blood flow may be involved, the biological mechanisms that underpin RBC haemolysis remain elusive. RBCs are potentially susceptible to lysis by autologous complement activation. RBCs are protected from the lytic effects of complement by regulatory proteins (CRPs) bound to the cell membrane via glycosylphosphatidylinositol (GPI) anchors. This study aimed to determine if marathon running would result in RBC haemolysis through a loss of membrane expression of the CRPs CD55 (decay accelerating factor) and CD59 (membrane attack complex inhibitory factor). Blood samples were obtained from 14 male runners before, within 30 min after, and 24 h after completion of the 2004 London Marathon. RBCs were assessed for cell surface CD55 and CD59 expression using indirect immunofluorescence assays and flow cytometry. No significant changes in the total RBC count, haematocrit or haemoglobin concentrations were found in response to running the marathon (P > 0.05). Blood bilirubin concentrations after the marathon were significantly greater than the pre-race values (P 0.05). In conclusion, marathon running did not alter the expression of CD55 or CD59 on RBCs, despite concomitant elevations in blood bilirubin concentrations. Consequently, any haemolysis of RBCs that occurred in response to the marathon was not likely due to a loss of membrane bound CRPs and subsequent cell lysis by autologous complement.

  9. Household Food Insecurity and Its Association with Nutritional Status of Children 6–59 Months of Age in East Badawacho District, South Ethiopia

    Science.gov (United States)

    Ejajo, Tekle; Alemseged, Fissahaye; Massa, Desalegn

    2017-01-01

    Background. Ethiopia has one of the highest child malnutrition rates in the world. Food insecurity is one of the determinant factors of malnutrition in developing countries; however its role remains unclear. Objective. To assess household food insecurity and its association with the nutritional status of children 6–59 months of age in East Badawacho District, South Ethiopia. Methods. A community based cross-sectional study was conducted from February 20 to 30, 2014 on a sample of 508 mother/child pairs of 6–59-month-old children. Sample households with eligible children were selected using systematic random sampling technique. Both bivariate and multivariate analysis were used to identify factors associated with nutritional status of children. P value of underweight, and wasting among children were 45.6%, 26.3%, and 14.6%, respectively. Household food insecurity was significantly associated with underweight (AOR = 3.82; CI = 1.78–8.19) and stunting (AOR = 6.7; CI = 3.71–12.1) but not with wasting. Conclusion and Recommendation. Household food insecurity and the prevalence rates of stunting, underweight, and wasting, among children 6 to 59 months, were high. Intervention programs should focus on improving household food insecurity and nutritional status of children. PMID:28408936

  10. Household Food Insecurity and Its Association with Nutritional Status of Children 6-59 Months of Age in East Badawacho District, South Ethiopia.

    Science.gov (United States)

    Betebo, Bealu; Ejajo, Tekle; Alemseged, Fissahaye; Massa, Desalegn

    2017-01-01

    Background . Ethiopia has one of the highest child malnutrition rates in the world. Food insecurity is one of the determinant factors of malnutrition in developing countries; however its role remains unclear. Objective . To assess household food insecurity and its association with the nutritional status of children 6-59 months of age in East Badawacho District, South Ethiopia. Methods . A community based cross-sectional study was conducted from February 20 to 30, 2014 on a sample of 508 mother/child pairs of 6-59-month-old children. Sample households with eligible children were selected using systematic random sampling technique. Both bivariate and multivariate analysis were used to identify factors associated with nutritional status of children. P value of underweight, and wasting among children were 45.6%, 26.3%, and 14.6%, respectively. Household food insecurity was significantly associated with underweight (AOR = 3.82; CI = 1.78-8.19) and stunting (AOR = 6.7; CI = 3.71-12.1) but not with wasting. Conclusion and Recommendation . Household food insecurity and the prevalence rates of stunting, underweight, and wasting, among children 6 to 59 months, were high. Intervention programs should focus on improving household food insecurity and nutritional status of children.

  11. O papel das proteínas reguladoras do complemento CD55/CD59 em células de sangue periférico de pacientes com lúpus eritematoso sistêmico The role of CD55/CD59 complement regulatory proteins on peripheral blood cells of systemic lupus erythematosus patients

    Directory of Open Access Journals (Sweden)

    Ana Paula Alegretti

    2009-06-01

    Full Text Available CD55 e CD59 são proteínas de membrana ancoradas por glicosilfosfatidilinositol que apresentam propriedades reguladoras da ativação da cascata do complemento. Essa regulação ocorre através da inibição da C3 convertase pelo CD55 e prevenção da etapa final de polimerização do complexo de ataque à membrana pelo CD59. Deficiência na expressão dessas proteínas pode estar associada a uma maior ativação do sistema complemento, inclusive do complexo de ataque à membrana, levando à morte celular. Pacientes com lúpus eritematoso sistêmico, com anemia hemolítica e linfopenia, parecem apresentar uma deficiência adquirida de CD55 e CD59. Contudo, os mecanismos que modulam essa diminuída expressão continuam desconhecidos e o seu impacto nas manifestações do lúpus eritematoso sistêmico precisa ser mais bem estudado.CD55 and CD59 are glycosylphosphatidylinositol-anchored proteins with regulatory properties on the activating cascades of the complement system. This regulation occurs through inhibition of the C3-convertase formation by CD55, and prevention of the terminal polymerization of the membrane attack complex by CD59. Deficiency in the expression of these proteins can be associated with increased susceptibility to complement-mediated cell death. Systemic lupus erythematosus patients with hemolytic anemia and lymphopenia seem to have an acquired deficiency of CD55 and CD59 proteins. However, the mechanisms involved in this deficiency and its impact on the clinical manifestation of SLE needs to be further investigated.

  12. Neonatal, 1-59 month, and under-5 mortality in 597 Indian districts, 2001 to 2012: estimates from national demographic and mortality surveys.

    Science.gov (United States)

    Ram, Usha; Jha, Prabhat; Ram, Faujdar; Kumar, Kaushalendra; Awasthi, Shally; Shet, Anita; Pader, Joy; Nansukusa, Stella; Kumar, Rajesh

    2013-10-01

    India has the largest number of child deaths of any country in the world, and has wide local variation in under-5 mortality. Worldwide achievement of the UN 2015 Millennium Development Goal for under-5 mortality (MDG 4) will depend on progress in the subregions of India. We aimed to estimate neonatal, 1-59 months, and overall under-5 mortality by sex for 597 Indian districts and to assess whether India is on track to achieve MDG 4. We divided the 2012 UN sex-specific birth and mortality totals for India into state totals using relative birth rates and mortality from recent demographic surveys of 24 million people, and divided state totals into totals for the 597 districts using 3 million birth histories. We then split the results into neonatal mortality and 1-59 month mortality using data for 109,000 deaths in children younger than 5 years from six national surveys. We compared results with the 2001 census for each district. Under-5 mortality fell at a mean rate of 3·7% (IQR 3·2-4·9) per year between 2001 and 2012. 222 (37%) of 597 districts are on track to achieve the MDG 4 of 38 deaths in children younger than 5 years per 1000 livebirths by 2015, but an equal number (222 [37%]) will achieve MDG 4 only after 2020. These 222 lagging districts are home to 41% of India's livebirths and 56% of all deaths in children younger than 5 years. More districts lag behind the relevant goal for neonatal mortality (251 [42%]) than for 1-59 month mortality (197 [33%]). Just 81 (14%) districts account for 37% of deaths in children younger than 5 years nationally. Female mortality at ages 1-59 months exceeded male mortality by 25% in 303 districts in nearly all states of India, totalling about 74,000 excess deaths in girls. At current rates of progress, MDG 4 will be met by India around 2020-by the richer states around 2015 and by the poorer states around 2023. Accelerated progress to reduce mortality during the neonatal period and at ages 1-59 months is needed in most Indian

  13. Diarrheal Disease in Rural Mozambique: Burden, Risk Factors and Etiology of Diarrheal Disease among Children Aged 0-59 Months Seeking Care at Health Facilities.

    Directory of Open Access Journals (Sweden)

    Tacilta Nhampossa

    Full Text Available Diarrheal disease remains a leading cause of illness and death, particularly in low-income countries. Its burden, microbiological causes and risk factors were examined in children aged 0-59 months living in Manhiça, rural southern Mozambique.Trends of diarrhea-related burden of disease were estimated during the period 2001-2012. A prospective, age-stratified and matched (by age, gender and geographical origin, case-control study was conducted during 2007-2011. Clinical, epidemiology, anthropometric measurement and fecal samples obtained from recruited children were used to estimate moderate-to-severe diarrhea (MSD weighted attributable fractions.Over the last decade the incidence of acute diarrhea has dropped by about 80%. Incidence of MSD per 100 child years at risk for the period 2007-2011 was 9.85, 7.73 and 2.10 for children aged 0-11, 12-23 and 24-59 months respectively. By adjusted population attributable fractions, most cases of MSD were due to rotavirus, Cryptosporidium, ETEC ST (ST only or ST/LT, Shigella and Adenovirus 40/41. Washing hands and having facilities to dispose child's stools were associated with a reduced risk of MSD, while giving stored water to the child was associated with an increased risk of MSD.Despite the predominantly decreasing trends observed throughout the last decade, diarrheal diseases remain today a major cause of morbidity among children aged 0-59 months living in this rural Mozambican area. Rotavirus, cryptosporidium, Shigella, ETEC ST and Adenovirus 40/41 were the most important aetiologies of MSD. Thus, well-known preventive strategies such as washing hands, improving the treatment of stored water, having facilities to dispose children stools, and accelerating the introduction of the rotavirus vaccine should be promoted on a wider scale to reduce the current burden of diarrheal diseases.

  14. Diet and nutritional status among children 24-59 months by seasons in a mountainous area of Northern Vietnam in 2012.

    Science.gov (United States)

    Huong, Le Thi; Xuan, Le Thi Thanh; Phuong, Le Hong; Huyen, Doan Thi Thu; Rocklöv, Joacim

    2014-01-01

    Seasonal variation affects food availability. However, it is not clear if it affects dietary intake and nutritional status of children in Vietnam. This paper aims at examining the seasonal variation in nutrition status and dietary intake of children aged 24-59 months. A repeated cross-sectional study design was used to collect data of changes in nutritional status and diets of children from 24 to 59 months through four seasons in Chiem Hoa district, Tuyen Quang province, a predominately rural mountainous province of northern Vietnam. The quantitative component includes anthropometric measurements, 24 hours dietary recall and socio-economic characteristics. The qualitative component was conducted through focus group discussions (FGDs) with mothers of the children surveyed in the quantitative component. The purpose of FGDs was to explore the food habits of children during the different seasons and the behaviours of their mothers in relation to the food that they provide during these seasons. The prevalence of underweight among children aged 24-59 months is estimated at around 20-25%; it peaked in summer (24.9%) and reached a low in winter (21.3%). The prevalence of stunting was highest in summer (29.8%) and lowest in winter (22.2%). The prevalence of wasting in children was higher in spring and autumn (14.3%) and lower in summer (9.3%). Energy intake of children was highest in the autumn (1259.3 kcal) and lowest in the summer (996.9 kcal). Most of the energy and the nutrient intakes during the four seasons did not meet the Vietnamese National Institute of Nutrition recommendation. Our study describes some seasonal variation in nutrition status and energy intake among children in a mountainous area northern Vietnam. Our study indicated that the prevalence of stunting and underweight was higher in summer and autumn, while the prevalence of wasting was higher in spring and autumn. Energy intake did not always meet national recommendations, especially in summer.

  15. On the signatures of companion formation in the spectral energy distributions of Sz54 and Sz59—the young stars with protoplanetary disks

    Science.gov (United States)

    Zakhozhay, O. V.

    2017-07-01

    We study spectral energy distributions of two young systems Sz54 and Sz59, that belong to Chameleon II star forming region. The results of the modeling indicate that protoplanetary disks of these systems contain gaps in the dust component. These gaps could be a result of a planetary or brown dwarf companion formation, because the companion would accumulate a disk material, moving along its orbit. In a present work we have determined physical characteristics of the disks. We also discuss possible companion characteristics, based on the geometrical parameters of the gaps.

  16. Persistent self-consciousness about facial appearance, measured with the Derriford appearance scale 59, in patients after long-term biochemical remission of acromegaly.

    Science.gov (United States)

    Roerink, S H P P; Wagenmakers, M A E M; Wessels, J F; Sterenborg, R B T M; Smit, J W; Hermus, A R M M; Netea-Maier, R T

    2015-06-01

    Acromegaly is associated with impaired quality of life (QoL) and causes anatomical disproportions, which may contribute to the decreased QoL after successful treatment. The Derriford appearance scale 59 (DAS59) is a questionnaire measuring psychological distress and disruptions to everyday life associated with self-consciousness of appearance. Investigate the psychological distress and dysfunction related to self-consciousness about appearance and its effect on QoL in patients in long-term remission of acromegaly. Patients (>18 years old) treated for acromegaly at the Department of Endocrinology of the Radboud University Medical Center Nijmegen were invited to participate. A gender-, age- and body mass index matched control group was provided by the patients themselves. Participants were asked to complete the modified DAS59-, research and development 36- (RAND-36), acromegaly quality of life questionnaire (AcroQoL) and a sociodemographic questionnaire. Differences between patient- and control groups and correlations between questionnaire scores and clinical characteristics collected from medical records were analyzed. Questionnaire scores. Of the 120 respondents, 73 agreed to participate [all cured or under biochemical control, median remission time 10.5 years (range 2.3-43.6 years)]. Of these, 34 (46.6%) reported self-consciousness about their appearance. Twenty-nine of these patients (85.3%) pointed out their face to be a prominent source of self-consciousness. Fifty-seven matched control subjects were included as well. Significant correlations were found between the scores of the DAS59 and the AcroQoL, RAND-36 and VAS in patients. Even after long-term remission of acromegaly, a large number of patients are self-conscious about their appearance, leading to psychological distress and disruptions to everyday life and decreased QoL. Facial features were the most important source of self-consciousness. This stresses the importance of addressing self-consciousness of

  17. Decay Data Evaluation Project (DDEP): Updated decay data evaluations for (24)Na, (46)Sc, (51)Cr, (54)Mn, (57)Co, (59)Fe, (88)Y, (198)Au.

    Science.gov (United States)

    Chechev, Valery P; Kuzmenko, Nikolay K

    2016-03-01

    Updated DDEP evaluations have been presented for the decay characteristics of the radionuclides (24)Na, (46)Sc, (51)Cr, (54)Mn, (57)Co, (59)Fe, (88)Y and (198)Au. Previous DDEP evaluations for these radionuclides were published in the BIPM-5 monographie in 2004. The experimental data published during the intervening period of 2004-2014 were taken into account in the current evaluations as well as other information: new compilations, analyses, and corrections. The updated evaluations are compared to previous results. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Degradation of Textile Dye Reactive Navy – Blue Rx (Reactive blue–59 by an Isolated Actinomycete Streptomyces krainskii SUK – 5

    Directory of Open Access Journals (Sweden)

    Mane, U. V.

    2008-01-01

    Full Text Available The isolated Actinomycete, Streptomyces krainskii, SUK -5 was found to decolorize and degrade textile dye Reactive blue–59.This azo dye was decolorized and degraded completely by Streptomyces krainskii SUK–5 at 24 h in shaking condition in the nutrient medium at pH 8. Induction in the activity of Lignin Peroxidase,and NADH-DCIP Reductase and MR reductase represents their role in degradation .The biodegradation was monitored by TLC, UV vis spectroscopy, FTIR. and GCMS analysis. Microbial and phytotoxicity studies of the product were carried out.

  19. Determinants of Acute Malnutrition among Children Aged 6–59 Months in Public Health Facilities of Pastoralist Community, Afar Region, Northeast Ethiopia: A Case Control Study

    Directory of Open Access Journals (Sweden)

    Anwar Seid

    2017-01-01

    Full Text Available Background. In low income countries, acute malnutrition continues to be the most important risk factor for illnesses and deaths. The aim of this study was to assess the determinants of acute malnutrition among children aged 6–59 months. Methods. A facility based unmatched case control study was employed on 420 (140 cases and 280 controls children aged 6–59 months with their caregivers between January 20 and February 20, 2014. Data was analyzed using SPSS version 20.0. A P value < 0.05 was considered statistically significant. Results. Children aged 12–23 months [AOR = 10.51, 95% CI = 4.93, 22.34], rural residence [AOR = 2.42, 95% CI = 1.22, 4.79], illiterate father [AOR = 2.47, 95% CI = 1.32, 4.61], Monthly income of less than 1000 birr [AOR = 3.98, 95% CI 2.05, 7.69], and food served together with family [AOR = 2.18, 95% CI = 1.10, 4.30] were associated with acute malnutrition. Conclusion. Rural residence, illiterate father, monthly income of less than 1000 birr, and food served together with family are statistically associated with acute malnutrition. Improving practices of parents on appropriate child feeding and creating awareness related to key risk factors of acute malnutrition should be further strengthened.

  20. Liver intake in 24-59-month-old children from an impoverished South African community provides enough vitamin A to meet requirements.

    Science.gov (United States)

    Nel, Jana; van Stuijvenberg, Martha E; Schoeman, Serina E; Dhansay, Muhammad A; Lombard, Carl J; du Plessis, Lisanne M

    2014-12-01

    To assess the contribution of liver to the vitamin A intake of 24-59-month-old children from an impoverished South African community where liver is frequently consumed and vitamin A deficiency previously shown to be absent. Cross-sectional. Northern Cape Province, South Africa. Children aged 24-59 months (n 150). Vitamin A intake from liver was assessed using a single 24 h recall and a quantified liver frequency questionnaire. In addition, information on vitamin A intake via the national fortification programme was obtained from the 24 h recall and information on vitamin A supplementation from the Road-to-Health Chart. Height, weight and socio-economic data were also collected. Stunting, underweight and wasting were prevalent in 36·9 %, 25·5 % and 12·1 % of children. Mean daily vitamin A intake from liver was 537 and 325 μg retinol equivalents measured by the 24 h recall and liver frequency questionnaire, respectively. Liver was consumed in 92·7 % of households and by 84·7 % of children; liver intake was inversely related to socio-economic status (P impoverished community. The results also challenge the notion generally held by international health bodies that vitamin A deficiency, poor anthropometric status and poverty go together, and reinforces the fact that South Africa is a culturally diverse society for which targeted interventions are required.

  1. Association of lower urinary tract symptoms and maximal oxygen uptake (VO2max) in men aged 50 to 59 years: a case-control study.

    Science.gov (United States)

    Brum, Christiano Silva; Rezende, Edson Campana; de Lima, Jorge Roberto Perrout; Santos, Isaias Chaves; Netto, Jose Murilo Bastos; Figueiredo, André Avarese

    2013-10-01

    To determine the association of lower urinary tract symptoms (LUTS) with maximal oxygen uptake (VO2max), flexibility, physical activity level, and anthropometric variables. A case-control study has been conducted in which LUTS was the outcome and VO2max, flexibility, physical activity level, and anthropometric variables the exposure variables. We evaluated 100 men aged between 50 and 59 years, assigning 49 to the case group and 51 to the control group. The patients underwent the following: physical activity level assessment using the International Physical Activity Questionnaire; LUTS assessment using the International Prostate Symptom Score Questionnaire; anthropometric assessment measuring body mass index, waist-to-hip ratio, and waist circumference; VO2max assessment through the Polar Fitness Test; and flexibility assessment using the Sit and Reach test. Multivariable analysis using a logistic regression model was performed for the assessment of odds ratio (OR) and 95% confidence interval (95% CI). In bivariable analysis, a statistically significant association was identified for LUTS with physical activity level (OR = 0.375, 95% CI = 0.167-0.841, P = .02); with VO2max (OR = 0.206, 95% CI = 0.086-0.495, P VO2max was the only statistically significant variable associated with LUTS (OR = 0.303, 95% CI = 0.105-0.875, P = .027). In men aged between 50 and 59 years, an association between inadequate VO2max with LUTS was found. Copyright © 2013 Elsevier Inc. All rights reserved.

  2. Correlation factors for C-14, Cl-36, Ni-59, Ni-63, Mo-93, Tc-99, I-129 and Cs-135. In operational waste for SFR 1

    Energy Technology Data Exchange (ETDEWEB)

    Lindgren, Maria; Pettersson, Michael; Wiborgh, Marie (Kemakta AB, Stockholm (SE))

    2007-01-15

    The use of correlation factors is one possibility to estimate a reference radionuclide inventory for the purpose of safety assessment studies, when waste-type specific information is not at hand. The correlation factor approach requires that there is a correlation between the activity content of the difficult-to-measure nuclide and the key nuclide. A safety assessment of a future deep repository for low and intermediate level waste (SFL 3-5) was conducted during the second half of the 1990's. Within that project, correlation factors for estimating the inventory of radionuclides which are difficult to measure experimentally were developed. These factors have also partly been used to estimate a reference inventory for SFR 1. Based on a literature survey and recent reports published by SKB, it is concluded that new information is available making an update of some correlation factors relevant. For these radionuclides, reported data from estimations and measurements of radionuclide content and correlation factors in different types of radioactive wastes are summarised. The data is evaluated and updated correlation factors representative for fresh waste for eight radionuclides (C-14, Cl-36, Ni-59, Ni-63, Mo-93, Tc-99, I-129 and Cs-135) are suggested. New information from measurements in Swedish NPP has made it possible to define factors that are BWR and PWR specific for C-14, Ni-59 and Ni-63. The uncertainties in suggested data and the applicability of the correlation factors for estimates of the radionuclide content in operational waste are commented upon

  3. [Validating mid-upper arm circumference (MUAC) measurement for detecting acute malnutrition in 6-59 month-old children in emergency and disaster situations].

    Science.gov (United States)

    Mantilla-Hernández, Laura C; Niño-Bautista, Lucila; Prieto-Pinilla, Elva E; Galvis-Padilla, Diana C; Bueno-Pérez, Inés

    2014-01-01

    Validating the results of mid-upper arm circumference (MUAC) measurement in 6-59 month-old children when MUAC was measured by community agents in areas where an emergency had been declared. Evaluating the cut-offs used for identifying children suffering from acute malnutrition in Colombia today. Previously trained community agents and a nutritionist carried out a cross-sectional study for evaluating MUAC agreement, reproducibility and sensitivity in detecting acute malnutrition. Three hundred and six children were assessed in three municipalities where an emergency had been declared in the Cordoba department of Colombia. A Bland and Altman plot gave high agreement regarding measurements taken by the community agents and the nutritionist, 94 % of the measurements coming within the agreement limits. The intra-class correlation coefficient gave 0.87 reproducibility; however, validating the criterion for calculating the area below the ROC curve, sensitivity and the impact of the children's age on MUAC measurements highlighted problems in using 11.5 centimeters as the cut-off. MUAC measurement was reliable, had good reproducibility and led to rapid diagnosis of nourishment status in 6-59 month-old children living in areas where an emergency had been declared. Validating the criterion, sensitivity, the impact of the children's age on MUAC measurement results and improved nourishment status concerning children aged less than 5 years old in Colombia highlighted the need for changing the current cut-off and using 14 centimeters instead.

  4. A direct estimate of poleward volume, heat and fresh water flux at 59.5°N between Greenland and Scotland

    Science.gov (United States)

    Rossby, Thomas; Reverdin, Gilles; Chafik, Leon; Søiland, Henrik

    2017-04-01

    The meridional overturning circulation (MOC) in the North Atlantic plays a major role in the transport of heat from low latitudes to high. In this study we combine recent measurements of currents from the surface to >700 m from a shipboard acoustic Doppler current profiler on the Nuka Arctica, a freighter in regular service between Greenland and Denmark with Argo profiles (to 2000 m) to estimate poleward volume, heat and freshwater flux at 59.5°N between Greenland and Scotland. For the period late 2012 to early 2016 the de-seasoned mean meridional overturning circulation reaches a 14.9±1.7 Sv maximum at the σθ = 27.55 kg m-3 isopycnal, which varies in depth from near the surface in the western Irminger Sea to 1000 m in Rockall Trough. The surface to bottom transport has a -0.44 Sv (southward) residual, which is not significantly different from zero. The total heat and fresh water fluxes across 59.5°N = 307 PW and 0.15 Sv, both with a 12% uncertainty principally due to uncertainties of the MOC. Comparing this ADCP dataset with an earlier one of comparable size from 1999-2002 (to 400 m depth only) shows strikingly similar transports in both west and east of the Reykjanes Ridge suggesting at least for these two periods 13 years apart very little difference in the strength of the MOC.

  5. Enhanced and persistent antibody response against homologous and heterologous strains elicited by a MF59-adjuvanted influenza vaccine in infants and young children.

    Science.gov (United States)

    Nolan, Terry; Bravo, Lulu; Ceballos, Ana; Mitha, Essack; Gray, Glenda; Quiambao, Beatriz; Patel, Sanjay S; Bizjajeva, Svetlana; Bock, Hans; Nazaire-Bermal, Nancy; Forleo-Neto, Eduardo; Cioppa, Giovanni Della; Narasimhan, Vas

    2014-10-21

    Non-adjuvanted seasonal influenza vaccines show only modest efficacy in young children. This study compared the immunogenicity, reactogenicity and safety of the MF59-adjuvanted trivalent subunit vaccine (aTIV) with two non-adjuvanted trivalent vaccines, TIV-1, the non-adjuvanted version of aTIV, and TIV-2, a split virion vaccine. 6078 children received two doses of aTIV (n=3125), TIV-1 (n=1479), or TIV-2 (n=1474) four weeks apart (Days 1 and 29). Children aged 6 to vaccination (Day 50), the aTIV group showed significantly higher geometric mean HI titers and seroconversion rates than the TIV-1 or TIV-2 groups against all homologous and heterologous strains. The difference was enhanced at HI titers ≥110. aTIV elicited a faster, more persistent antibody response, with significantly higher titers in the aTIV group after one vaccination (Day 29) and after six months (Day 209) than in either TIV group. aTIV was more reactogenic than were TIV-1 and TIV-2 but rates of severe adverse events were very low for all three vaccines. In infants and young children, the MF59-adjuvanted vaccine induced substantially faster (after one dose), higher, persistent HI titers than the non-adjuvanted vaccines, with consistently higher seroprotection rates at increased threshold HI titers. This trial is registered at clinicaltrials.gov: NCT01346592. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Age-period-cohort analysis of colorectal cancer, service members aged 20-59 years, active component, U.S. Armed Forces, 1997-2016.

    Science.gov (United States)

    Stahlman, Shauna; Oetting, Alexis

    2017-07-01

    In the U.S. general population, incidence of colorectal cancer appears to be increasing in younger age groups since the mid-1980s. The objective of this report was to better understand the time-varying elements (age, period, and birth cohort effects) in the epidemiology of colorectal cancer among the active component of the U.S. Armed Forces. During 1997-2016, there were 1,108 incident cases of colorectal cancer among service members aged 20-59 years, corresponding to an overall incidence rate of 4.3 per 100,000 person-years (p-yrs). Rates were particularly high among men (4.4 per 100,000 p-yrs) and non- Hispanic black service members (5.3 per 100,000 p-yrs). Overall crude incidence of colorectal cancer increased in an exponential fashion with increasing age groups until the oldest age group (55-59 years), in which the increase was attenuated. No birth cohort or period effects were identified in the age-period-cohort analysis. This finding could be due to limited power, selection bias, better screening practices in the Military Health System (MHS) compared with the general population, or true lack of effects. Continued population-based screening for colorectal cancer in the MHS is recommended to maintain low and decreasing incidence in the U.S. Armed Forces.

  7. Genome comparisons of two Taiwanese community-associated methicillin-resistant Staphylococcus aureus ST59 clones support the multi-origin theory of CA-MRSA.

    Science.gov (United States)

    Feng, Ye; Chen, Hsiu-Ling; Chen, Chih-Jung; Chen, Chyi-Liang; Chiu, Cheng-Hsun

    2017-10-01

    Sequence type (ST) 59 is an epidemic lineage of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in Asia. Two ST59 clones are prevalent in Taiwan: the Taiwan clone (TW) causes severe infections, whereas the Asian-Pacific clone (AP) is usually commensal. In this study, we sequenced the genome and transcriptome of the representative strains of these two clones and found their differences to focus on three mobile genetic elements: TW carries SCCmec Type V T , Panton-Valentine leucocidin (PVL)-encoding prophage ΦSa2, whereas AP carries SCCmec Type IV and staphylokinase (SAK)-encoding prophage ΦSa3. The anti-virulent role of SAK was confirmed using murine skin and bloodstream infection models. ΦSa3 usually integrates into the hlb gene, but in AP was found to be integrated at the genomic island νSaβ. The mutation of the attB site "TGTATCCAAACTGG" to "TGTATCCGAATTGG" led to a failure in the integration of ΦSa3 in hlb, prompting atypical integration at other sites. The sak gene possessed remarkably different patterns of distribution among the different STs of S. aureus. We conclude that the atypical integration of ΦSa3 may help S. aureus adapt to the human host habitat and that the subsequent loss of ΦSa3 contributes toward the development of a virulent CA-MRSA lineage for wider horizontal transmission. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. PREVALENSI HIPERTENSI DAN KEBIASAAN MEROKOK, KONSUMSI ALKOHOL, SERTA KONSUMSI GARAM PADA PENDUDUK USIA 20-59 TAHUN DI WILAYAH KERJA UPTD PUSKESMAS KUBU II

    Directory of Open Access Journals (Sweden)

    Uttari Priyadarshini

    2016-03-01

    Full Text Available PREVALENCE OF HYPERTENSION AND SMOKING HABITS, ALKOHOL CONSUMPTION, AND CONSUMPTION OF SALT IN THE POPULATION AGED 20-59 YEARS IN THE WORKING AREA UPTD KUBU HEALTH CENTER II ABSTRACT From the report of UPTD Puskesmas Kubu II in 2012, hypertension was one of the tenmost frequent illnesses in their working area. Hypertension is connected with smoking habit, alcohol and salt consumption. The purpose of this study is to describe the prevalence of hypertension and smoking habit, consumption of alcohol and salt among the villagers in the working area of UPTD Puskesmas Kubu II. This research was conducted in August 2012 atworking area of UPTD Puskesmas Kubu II with a cross-sectional study design which was participated by 80 samples within 20-59 years old. Data were collected directly using an anthropometric measurements, blood pressure measurement and questionnaires. The result showed that hypertension tends to affect villagers who drinkalcohol ≥ 7 times per week and smoke>20ciggarettes per day. We may conclude that the prevalence of hypertension among villagersinworking area of UPTD Puskesmas Kubu IIis quite high. There are also tendencies of bad habit regarding risk factor of hypertension. This requires further attention.

  9. Feasibility of laparoscopic abdomino-perineal resection for large-sized anorectal cancers: a single-institution experience of 59 cases.

    Science.gov (United States)

    Shukla, Parul J; Barreto, Savio G; Hawaldar, Rohini; Nadkarni, Mandar; Kanitkar, Gajanan A; Kerkar, Rajendra; Shrikhande, Shailesh V

    2009-03-01

    Laparoscopic surgery for anorectal carcinoma is steadily gaining acceptance. While feasibility has already been reported, there are no reports addressing the impact of the actual size of large tumors on laparoscopic resectability. To assess the feasibility and short-term results (including oncological surrogate end points) of performing laparoscopic abdomino-perineal resection (APR) for large rectal cancers. Data of 59 patients undergoing laparoscopic APR (LAPR) for anorectal malignancies were reviewed retrospectively. Outcomes were evaluated considering the surgical procedure, surface area of the tumor and short-term outcomes. Of the 59 cases, LAPR could be completed in 53 (89.8%) patients. Thirty-one (58.4%) patients had Astler-Coller C2 stage disease. The mean surface area of the tumors was 24+/-17.5 (4-83) cm2. The number of median lymph nodes harvested per case was 12 (1-48). Circumferential resection margin (CRM) was positive in 11 (20.7%) patients. No mortality was reported. This appears to be the first report analyzing the impact of the size of the rectal tumor in LAPR. The data clearly indicates that LAPR is not hampered by the size of the tumor. There appears to be a need for preoperative radiotherapy and chemotherapy before undertaking surgery on larger tumors in view of the higher circumferential resection margin positivity.

  10. Excitations, optical absorption spectra, and optical excitonic gaps of heterofullerenes: I. C60, C59N+ and C48N12

    Energy Technology Data Exchange (ETDEWEB)

    Xie, R; Bryant, G W; Sun, G; C.Nicklaus, M; Heringer, D; Frauenheim, T; Manaa, M R; Smith, Jr., V H; Araki, Y; Ito, O

    2003-10-02

    Low-energy excitations and optical absorption spectrum of C{sub 60} are computed by using time-dependent (TD) Hartree-Fock (HF), TD-density functional theory (TD-DFT), TD-DFT-based tight-binding (TD-DFT-TB) and a semiempirical ZINDO method. A detailed comparison of experiment and theory for the excitation energies, optical gap and absorption spectrum of C{sub 60} is presented. It is found that electron correlations and collective effects of exciton pairs play important roles in assigning accurately the spectral features of C{sub 60} and the TD-DFT method with non-hybrid functionals or a local spin density approximation leads to more accurate excitation energies than with hybrid functionals. The level of agreement between theory and experiment for C{sub 60} justifies similar calculations of the excitations and optical absorption spectrum of a monomeric azafullerene cation C{sub 59}N{sup +} exhibits distinguishing spectral features different from C{sub 60}: (1) the first singlet is dipole-allowed and the optical gap is redshifted by 1.44 eV; (2) several weaker absorption maxima occur in the visible region; (3) the transient triplet-triplet absorption at 1.60 eV (775 nm) is much broader and the decay of the triplet state is much faster. The calculated spectra of C{sub 59}N{sup +} characterize and explain well our measured ultraviolet-visible (UV-vis) and transient absorption spectra of the carborane anion salt [C{sub 59}N][Ag(CB{sub 11}H{sub 6}Cl{sub 6}){sub 2}]. For the most stable isomer of C{sub 48}N{sub 12}, we predict that the first singlet is dipole-allowed, the optical gap is redshifted by 1.22 eV relative to that of C{sub 60}, and optical absorption maxima occur at 585, 528, 443, 363, 340, 314 and 303 nm. We point out that the characterization of the UV-vis and transient absorption spectra of C{sub 48}N{sub 12} isomers is helpful in distinguishing the isomer structures required for applications in molecular electronics. For C{sub 59}N{sup +} and C{sub 48}N

  11. Prevalência e fatores associados à obesidade abdominal em indivíduos na faixa etária de 25 a 59 anos do Estado de Pernambuco, Brasil Prevalencia y factores asociados a la obesidad abdominal en individuos en una franja de edad de 25 a 59 años del estado de Pernambuco, Brasil Prevalence of abdominal obesity and associated factors among individuals 25 to 59 years of age in Pernambuco State, Brazil

    Directory of Open Access Journals (Sweden)

    Claudia Porto Sabino Pinho

    2013-02-01

    Full Text Available Com o objetivo de estimar a prevalência de obesidade abdominal e avaliar os fatores associados em adultos do Estado de Pernambuco, Brasil, foi realizado, em 2006, um estudo transversal, de base populacional, envolvendo 1.580 indivíduos na faixa etária de 25-59 anos. A obesidade abdominal foi determinada pela circunferência da cintura ≥ 80cm para mulheres e ≥ 94cm para homens. O modelo conceitual considerou variáveis socioeconômicas, demográficas, reprodutivas e comportamentais. A prevalência de obesidade abdominal foi de 27,1% (IC95%: 23,8-30,7 no sexo masculino e 69,9% (IC95%: 66,8-72,8 no feminino (p Con el objetivo de estimar la prevalencia de obesidad abdominal y evaluar los factores asociados en adultos del estado de Pernambuco, Brasil, se realizó, en 2006, un estudio transversal, de base poblacional, involucrando a 1.580 individuos en una franja de edad de 25-59 años. La obesidad abdominal fue determinada por la circunferencia de la cintura ≥ 80cm para mujeres y ≥ 94cm para hombres. El modelo conceptual consideró variables socioeconómicas, demográficas, reproductivas y de comportamiento. La prevalencia de obesidad abdominal fue de un 27,1% (IC95%: 23,8-30,7 en el sexo masculino y un 69,9% (IC95%: 66,8-72,8 en el femenino (p In order to estimate the prevalence of abdominal obesity and associated factors in Pernambuco State, Brazil, a cross-sectional population-based study was conducted in 2006, including 1,580 adults 25 to 59 years of age. Abdominal obesity was defined as waist circumference (WC ≥ 80cm in women and ≥ 94cm in men. The conceptual model included demographic, socioeconomic, reproductive, and behavioral variables. Prevalence of abdominal obesity was 27.1% (95%CI: 23.8-30.7 in males and 69.9% (95%CI: 66.8-72.8 in females (p < 0.001. Multivariate analysis showed higher prevalence in men 50 years or older in the metropolitan area and those with higher income, former smokers, and drinkers. Among women

  12. South African Crime Quarterly 59

    African Journals Online (AJOL)

    and Others v South African Rugby Football. Union and Others, an .... administration and administrative activities to ensure that the exercise of public powers does not adversely affect the rights of individuals.47. It is clear that administrative law effectively regulates what the administration may or may not do, and what ...

  13. South African Crime Quarterly 59

    African Journals Online (AJOL)

    and penalise non-compliance. How has this emphasis on accountability translated into practice? What, specifically, have been its effects on the policing of intimate partner violence? To answer these questions, this article begins by detailing the framework of police accountability created by the Domestic Violence Act (DVA),.

  14. Compilation of Reprints, Number 59.

    Science.gov (United States)

    1981-11-01

    identify by block number) Organic detritus passing from the sea surface through the water column to the sea floor controls nutrient regeneration, fules ...ot burn :! cumt,r Ind tiepi-huid livers, nii irlier itr oif this tnlnt;,s lpt Lill. :r- ’le 1 i ’ (,(ti-i;~ lc~su Iiii i- thi l’rrruiiiin tii peile.- ft...Fate of Fossil CO2 in the eastern equatorial Atlantic. Science, 198. p. 605-608. Oceans, Plenum Press, New York. BERNER R.A. (1974). - Kinetic models

  15. South African Crime Quarterly 59

    African Journals Online (AJOL)

    Johan Burger (JB): Who is Gary Kruser? Where do you come from? What makes you tick? Gary Kruser (GK): I was born in Athlone, in Cape Town. It's surrounded by a lot of gangsterism and inequality. We grew up under the apartheid system, and we are primarily a coloured community. What makes me tick is to ensure ...

  16. South African Crime Quarterly 59

    African Journals Online (AJOL)

    In February this year, Statistics South Africa (Stats SA) released the findings of the 2015/16 Victims of Crime Survey, and announced that it would release the 2016/17 results in November. Victim surveys, though not without fault, capture valuable data relating to crime, justice and safety that are not typically collected by ...

  17. South African Crime Quarterly 59

    African Journals Online (AJOL)

    topic has been covered in the media, we sought. • The murder of private investigator Kevin. Trytsman, allegedly by his ... interviews with criminal associates, journalists, private investigators and prominent figures in ..... European bank accounts.28 It was this existing system that Krejcir exploited with Alekos Panayi, a banker ...

  18. South African Crime Quarterly 59

    African Journals Online (AJOL)

    'observatory' has expanded recently, from its origins in astronomy to that of specialised informational repositories and knowledge-building centres, housing cross-referenced databases with advanced analytic and research capacities. This review essay provides information regarding the conceptual framework, historical ...

  19. Coincident emission of neutrons and charged particles after π- absorption in 6Li, 7Li, 12C, 59Co and 197Au

    Science.gov (United States)

    Heusi, P.; Isaak, H. P.; Pruys, H. S.; Engfer, R.; Hermes, E. A.; Kozlowski, T.; Sennhauser, U.; Walter, H. K.

    1983-10-01

    Energy spectra d 3W/d E1 d E2 d cos ϑ of neutron-neutron and neutron-charged particle pairs (nn, np, nd, nt) emitted after the absorption of stopped negative pions in 6Li, 7Li, 12C, 59Co and 197Au have been measured for opening angles between 50° and 180°. Particle pairs emitted from light nuclei without energy loss due to final-state interactions were identified by the energy balance. Pion absorption on two nucleons (quasi-deuteron mechanism) was found to be the main process. The yields of nucleon pairs from quasi-free absorption on a quasi-deuteron are 0.52 ± 0.09 per π-stop, 0.57 ± 0.10 per π-stop and 0.19 ± 0.04 per π-stop for 6Li, 7Li and 12C, respectively. The ratio R of np to pp pairs that absorb the pion was determined for quasi-free absorption on p-shell nucleons of 12C: R(p-shell) = 6.3 ± 1.4. For pion absorption on s-shell nucleons of lithium lower limits R(s-shell) > 4.4 for 6Li and R(s-shell) > 7.8 for 7Li were determined. These values are larger than the statistical ratios Rstat = 2 N/( Z - 1) of np to pp pairs in the nucleus. Lower limits for the probability for pion absorption on heavier clusters ( 3He, α) are W(hc) > 0.16 per π-stop for 6Li, W(hc) > 0.11 per π-stop for 7Li and W( α) > 0.01 per π-stop for 12C. The shape of the energy spectra of pairs emitted directly after quasi-free absorption on 2 or 4 nucleons could be explained by a simple model for the momentum distribution of the absorbing nucleons. The results are in agreement with the parameters of the momentum distributions known from other reactions. Energy spectra and opening-angle distributions were compared with the intranuclear cascade calculations of Chiang, Hüfner and Hachenberg. For 59Co and 197Au the spectra are strongly influenced by the final-state interactions; lower limits of R > 1.8 for 59Co and R > 2.5 for 197Au were determined.

  20. Coincident emission of neutrons and charged particles after. pi. /sup -/ absorption in /sup 6/Li, /sup 7/Li, /sup 12/C, /sup 59/Co and /sup 197/Au

    Energy Technology Data Exchange (ETDEWEB)

    Heusi, P.; Isaak, H.P.; Pruys, H.S.; Engfer, R.; Hermes, E.A. (Zurich Univ. (Switzerland). Physik-Institut); Kozlowski, T.; Sennhauser, U.; Walter, H.K. (Eidgenoessische Technische Hochschule, Zurich (Switzerland). Lab. fuer Hochenergiephysik)

    1983-10-17

    Energy spectra d/sup 3/W/dE/sub 1/dE/sub 2/ d cos theta of neutron-neutron and neutron-charged particle pairs (nn, np, nd, nt) emitted after the absorption of stopped negative pions in /sup 6/Li, /sup 7/Li, /sup 12/C, /sup 59/Co and /sup 197/Au have been measured for opening angles between 50/sup 0/ and 180/sup 0/. Particle pairs emitted from light nuclei without energy loss due to final-state interactions were identified by the energy balance. Pion absorption on two nucleons (quasi-deuteron mechanism) was found to be the main process. The yields of nucleon pairs from quasi-free absorption on a quasi-deuteron are 0.52 +- 0.09 per ..pi..-stop, 0,57 +- 0.10 per ..pi..-stop and 0.19 +- 0.04 per ..pi..-stop for /sup 6/Li, /sup 7/Li and /sup 12/C, respectively. The ratio R of np to pp pairs that absorb the pion was determined for quasi-free absorption on p-shell nucleons of /sup 12/C: R(p-shell)=6.3 +- 1.4. For pion absorption on s-shell nucleons of lithium lower limits R(s-shell) > 4.4 for /sup 6/Li and R(s-shell) > 7.8 for /sup 7/Li were determined. These values are larger than the statistical ratios Rsub(stat)=2N/(Z-1) of np to pp pairs in the nucleus. Lower limits for the probability for pion absorption on heavier clusters (/sup 3/He, ..cap alpha..) are W(hc) > 0.16 per ..pi..-stop for /sup 6/Li, W (hc) > 0.11 per ..pi..-stop for /sup 7/Li and W(..cap alpha..) > 0.01 per ..pi..-stop for /sup 12/C. The shape of the energy spectra of pairs emitted directly after quasi-free absorption on 2 or 4 nucleons could be explained by a simple model for the momentum distribution of the absorbing nucleons. The results are in agreement with the parameters of the momentum distributions known from other reactions. Energy spectra and opening-angle distributions were compared with the intranuclear cascade calculations of Chiang, Huefner, and Hachenberg. For /sup 59/Co and /sup 197/ Au the spectra are strongly influenced by the final-state interactions; lower limits of R > 1.8 for /sup

  1. Short-course versus long-course intravenous therapy with the same antibiotic for severe community-acquired pneumonia in children aged two months to 59 months.

    Science.gov (United States)

    Lassi, Zohra S; Imdad, Aamer; Bhutta, Zulfiqar A

    2015-06-16

    Pneumonia remains the single leading cause of childhood mortality, causing an estimated 1.3 million childhood deaths each year in children under the age of five years. The greater burden of disease occurs in low-income countries, where medical resources and hospital-based management are poor. The World Health Organization (WHO) current evidence summaries recommend intravenous antibiotics for five days as first-line treatment for severe pneumonia. Although there is controversy around the specificity of clinical features in the diagnosis of pneumonia, the criteria for the diagnosis of severe pneumonia are better defined and widely used to triage children for referral and second-line therapy.Approximately 120 million new cases of pneumonia occur globally each year in children under five years of age, of which 14 million progress to severe episodes. Hospitalisation for severe pneumonia in children places a significant burden on both patients and their families, including substantial expense, loss of routine and decrease in quality of life. By reducing the duration of treatment in the hospital, this burden could potentially be lessened and possibly lead to better treatment compliance. To evaluate the efficacy of short-course (two to three days) versus long-course (five days) intravenous therapy with the same antibiotic for severe community-acquired pneumonia (CAP) in children aged two months to 59 months. We searched CENTRAL (2015, Issue 1), MEDLINE (1966 to January week 4, 2015) and EMBASE (1974 to February 2015). Randomised controlled trials (RCTs) evaluating the efficacy of short-course (two to three days) versus long-course (five days) intravenous antibiotic therapy for severe pneumonia in children aged two months to 59 months. We excluded children with any other debilitating disease, including those infected with HIV and we excluded children with signs and symptoms of very severe pneumonia (i.e. unable to drink or breast feed, vomiting, lethargic, unconscious

  2. Biochemical and pathological changes in the male rat kidney and bladder following exposure to continuous 900-MHz electromagnetic field on postnatal days 22-59.

    Science.gov (United States)

    Türedi, Sibel; Kerimoğlu, Gökçen; Mercantepe, Tolga; Odacı, Ersan

    2017-09-01

    To investigate the effect on male rat kidney and bladder tissues of exposure to 900-megahertz (MHz) electromagnetic field (EMF) applied on postnatal days 22-59, inclusive. Twenty-four male Sprague Dawley rats, aged 21 days, were used. These were divided equally into one of three groups, control (CG), sham (SG) or EMF (EMFG). CG was not exposed to any procedure. SG rats were kept inside a cage, without being exposed to the effect of EMF, for 1 h a day on postnatal days 22-59, inclusive. EMFG rats were exposed to continuous 900-MHz EMF for 1 h a day under the same conditions as those for the SG rats. Rats were sacrificed on postnatal day 60, and the kidney and bladder tissues were removed. Tissues were stained with hematoxylin and eosin (H&E) and Masson trichrome for histomorphological evaluation. The TUNEL method was used to assess apoptosis. Transmission electron microscopy (TEM) was also used for the kidney tissue. Oxidant/antioxidant parameters were studied in terms of biochemical values. The findings showed that tissue malondialdehyde increased in EMFG compared to CG and SG in both kidney (p = 0.004 and p = 0.004, respectively) and bladder tissue (p = 0.004, p = 0.006, respectively), while catalase and glutathione levels decreased compared to CG (p = 0.004; p = 0.004, respectively) and SG (p = 0.004; p = 0.004, respectively). In the EMF group, pathologies such as dilatation and vacuolization in the distal and proximal tubules, degeneration in glomeruli and an increase in cells tending to apoptosis were observed in kidney tissue. In bladder tissue, degeneration in the transitional epithelium and stromal irregularity and an increase in cells tending to apoptosis were observed in EMFG. Additionally, EMFG samples exhibited glomerular capillary degeneration with capillary basement membranes under TEM. We conclude that continuous exposure to the effect of 900-MHz EMF for 1 h a day on postnatal days 22-59, inclusive, causes an

  3. Production of multiple transgenic Yucatan miniature pigs expressing human complement regulatory factors, human CD55, CD59, and H-transferase genes.

    Directory of Open Access Journals (Sweden)

    Young-Hee Jeong

    Full Text Available The present study was conducted to generate transgenic pigs coexpressing human CD55, CD59, and H-transferase (HT using an IRES-mediated polycistronic vector. The study focused on hyperacute rejection (HAR when considering clinical xenotransplantation as an alternative source for human organ transplants. In total, 35 transgenic cloned piglets were produced by somatic cell nuclear transfer (SCNT and were confirmed for genomic integration of the transgenes from umbilical cord samples by PCR analysis. Eighteen swine umbilical vein endothelial cells (SUVEC were isolated from umbilical cord veins freshly obtained from the piglets. We observed a higher expression of transgenes in the transgenic SUVEC (Tg SUVEC compared with the human umbilical vein endothelial cells (HUVEC. Among these genes, HT and hCD59 were expressed at a higher level in the tested Tg organs compared with non-Tg control organs, but there was no difference in hCD55 expression between them. The transgenes in various organs of the Tg clones revealed organ-specific and spatial expression patterns. Using from 0 to 50% human serum solutions, we performed human complement-mediated cytolysis assays. The results showed that, overall, the Tg SUVEC tested had greater survival rates than did the non-Tg SUVEC, and the Tg SUVEC with higher HT expression levels tended to have more down-regulated α-Gal epitope expression, resulting in greater protection against cytotoxicity. By contrast, several Tg SUVEC with low CD55 expression exhibited a decreased resistance response to cytolysis. These results indicated that the levels of HT expression were inversely correlated with the levels of α-Gal epitope expression and that the combined expression of hCD55, hCD59, and HT proteins in SUVECs markedly enhances a protective response to human serum-mediated cytolysis. Taken together, these results suggest that combining a polycistronic vector system with SCNT methods provides a fast and efficient alternative

  4. Implementation of the directive 2013/59 EURATOM from the view of a federal state authority - new challenges for the federal state authorities in the frame of the federal executive administration; Umsetzung der Richtlinie 2013/59 EURATOM aus Sicht einer Landesbehoerde. Neue Herausforderungen fuer die Landesbehoerde im Rahmen der Bundesauftragsverwaltung im Strahlenschutz

    Energy Technology Data Exchange (ETDEWEB)

    Lorenz, J. [Saechsisches Staatsministerium fuer Umwelt und Landwirtschaft, Dresden (Germany). Referat Strahlenschutz, Gentechnik und Chemikalien; Honolka, J. [Saechsisches Landesamt fuer Umwelt, Landwirtschaft und Geologie, Dresden (Germany). Referat Strahlenschutz

    2016-07-01

    The directive 2013/59 EURATOM must be implemented in Germany by the Federal Environment Ministry until 2018. The implementation is to modernize the law in the field of the Radiation Protection in Germany. New assignments are coming to the Saxon authorities. The implementation of Article 63 in the field of medicine will be described in more detail and the problems for the authorities in Saxony are discussed. The new tasks require additional staff.

  5. 5.9 Mb microdeletion in chromosome band 17q22-q23.2 associated with tracheo-esophageal fistula and conductive hearing loss.

    Science.gov (United States)

    Puusepp, Helen; Zilina, Olga; Teek, Rita; Männik, Katrin; Parkel, Sven; Kruustük, Katrin; Kuuse, Kati; Kurg, Ants; Ounap, Katrin

    2009-01-01

    Only eight cases involving deletions of chromosome 17 in the region q22-q24 have been reported previously. We describe an additional case, a 7-year-old boy with profound mental retardation, severe microcephaly, facial dysmorphism, symphalangism, contractures of large joints, hyperopia, strabismus, bilateral conductive hearing loss, genital abnormality, psoriasis vulgaris and tracheo-esophageal fistula. Analysis with whole-genome SNP genotyping assay detected a 5.9 Mb deletion in chromosome band 17q22-q23.2 with breakpoints between 48,200,000-48,300,000 bp and 54,200,000-54,300,000 bp (according to NCBI 36). The aberration was confirmed by real-time quantitative PCR analysis. Haploinsufficiency of NOG gene has been implicated in the development of conductive hearing loss, skeletal anomalies including symphalangism, contractures of joints, and hyperopia in our patient and may also contribute to the development of tracheo-esophageal fistula and/or esophageal atresia.

  6. Strongly screening electron capture for nuclides 52, 53, 59, 60Fe by the Shell-Model Monte Carlo method in pre-supernovae

    Science.gov (United States)

    Liu, Jing-Jing; Peng, Qiu-He; Liu, Dong-Mei

    2017-09-01

    The death of massive stars due to supernova explosions is a key ingredient in stellar evolution and stellar population synthesis. Electron capture (EC) plays a vital role in supernova explosions. Using the Shell-Model Monte Carlo method, based on the nuclear random phase approximation and linear response theory model for electrons, we study the strong screening EC rates of 52, 53, 59, 60Fe in pre-supernovae. The results show that the screening rates can decrease by about 18.66%. Our results may become a good foundation for future investigation of the evolution of late-type stars, supernova explosion mechanisms and numerical simulations. Supported by National Natural Science Foundation of China (11565020), Counterpart Foundation of Sanya (2016PT43), Special Foundation of Science and Technology Cooperation for Advanced Academy and Regional of Sanya (2016YD28), Scientific Research Staring Foundation for 515 Talented Project of Hainan Tropical Ocean University (RHDRC201701) and Natural Science Foundation of Hainan Province (114012)

  7. Mass attenuation coefficient of binderless, pre-treated and tannin-based Rhizophora spp. particleboards using 16.59 - 25.26 keV photon energy range

    Science.gov (United States)

    Mohd Yusof, Mohd Fahmi; Hamid, Puteri Nor Khatijah Abdul; Bauk, Sabar; Hashim, Rokiah; Tajuddin, Abdul Aziz

    2015-04-01

    The Rhizophora spp. particleboards were fabricated using ≤ 104 µm particle size at three different fabrication methods; binderless, steam pre-treated and tannin-added. The mass attenuation coefficient of Rhizophora spp. particleboards were measured using x-ray fluorescent (XRF) photon from niobium, molybdenum, palladium, silver and tin metal plates that provided photon energy between 16.59 to 25.26 keV. The results were compared to theoretical values for water calculated using photon cross-section database (XCOM).The results showed that all Rhizophora spp. particleboards having mass attenuation coefficient close to calculated XCOM for water. Tannin-added Rizophora spp. particleboard was nearest to calculated XCOM for water with χ2 value of 13.008 followed by binderless Rizophora spp. (25.859) and pre-treated Rizophora spp. (91.941).

  8. Close-packed Arrays of Transition-edge X-ray Microcalorimeters with High Spectral Resolution at 5.9 keV

    Science.gov (United States)

    Iyomoto, N.; Bandler, S. R.; Brekosky, R. P.; Brown, A.-D.; Chervenak, J. A.; Finkbeiner, F. M.; Kelley, R. L.; Kilbourne, C. A.; Porter, F. S.; Sadleir, J. E.; hide

    2007-01-01

    We present measurements of high fill-factor arrays of superconducting transition-edge x-ray microcalorimeters designed to provide rapid thermalization of the x-ray energy. We designed an x-ray absorber that is cantilevered over the sensitive part of the thermometer itself, making contact only at normal metal-features. With absorbers made of electroplated gold, we have demonstrated an energy resolution between 2.4 and 3.1 eV at 5.9 keV on 13 separate pixels. We have determined the thermal and electrical parameters of the devices throughout the superconducting transition, and, using these parameters, have modeled all aspects of the detector performance.

  9. Intranasal Immunization Using Mannatide as a Novel Adjuvant for an Inactivated Influenza Vaccine and Its Adjuvant Effect Compared with MF59.

    Directory of Open Access Journals (Sweden)

    Shu-Ting Ren

    Full Text Available Intranasal vaccination is more potent than parenteral injection for the prevention of influenza. However, because the poor efficiency of antigen uptake across the nasal mucosa is a key issue, immunostimulatory adjuvants are essential for intranasal vaccines. The immunomodulator mannatide or polyactin (PA has been used for the clinical treatment of impaired immunity in China, but its adjuvant effect on an inactivated trivalent influenza vaccine (ITIV via intranasal vaccination is unclear. To explore the adjuvant effect of PA, an inactivated trivalent influenza virus with or without PA or MF59 was instilled intranasally once a week in BALB/c mice. Humoral immunity was assessed by both the ELISA and hemagglutination inhibition (HI methods using antigen-specific antibodies. Splenic lymphocyte proliferation and the IFN-γ level were measured to evaluate cell-mediated immunity. The post-vaccination serum HI antibody geometric mean titers (GMTs for the H1N1 and H3N2 strains, antigen-specific serum IgG and IgA GMTs, mucosal SIgA GMT, splenic lymphocyte proliferation, and IFN-γ were significantly increased in the high-dose PA-adjuvanted vaccine group. The seroconversion rate and the mucosal response for the H3N2 strain were significantly elevated after high-dose PA administration. These adjuvant effects of high-dose PA for the influenza vaccine were comparable with those of the MF59 adjuvant, and abnormal signs or pathological changes were not found in the evaluated organs. In conclusion, PA is a novel mucosal adjuvant for intranasal vaccination with the ITIV that has safe and effective mucosal adjuvanticity in mice and successfully induces both serum and mucosal antibody responses and a cell-mediated response.

  10. Directly measured currents and estimated transport pathways of Atlantic Water between 59.5°N and the Iceland–Faroes–Scotland Ridge

    Directory of Open Access Journals (Sweden)

    Katelin H. Childers

    2015-11-01

    Full Text Available Using vessel-mounted acoustic Doppler current profiler data from four different routes between Scotland, Iceland and Greenland, we map out the mean flow of water in the top 400 m of the northeastern North Atlantic. The poleward transport east of the Reykjanes Ridge (RR decreases from ~8.5 to 10 Sv (1 Sverdrup=106 m3 s−1 at 59.5°N to 61°N to 6 Sv crossing the Iceland–Faroes–Scotland Ridge. The two longest ~1200 km transport integrals have 1.4–0.94 Sv uncertainty, respectively. The overall decrease in transport can in large measure be accounted for by a ~1.5 Sv flow across the RR into the Irminger Sea north of 59.5°N and by a ~0.5 Sv overflow of dense water along the Iceland–Faroes Ridge. A remaining 0.5 Sv flux divergence is at the edge of detectability, but if real could be accounted for through wintertime convection to >400 m and densification of upper ocean water. The topography of the Iceland Basin and the banks west of Scotland play a fundamental role in controlling flow pathways towards and past Iceland, the Faroes and Scotland. Most water flows north unimpeded through the Iceland Basin, some in the centre of the basin along the Maury Channel, and some along Hatton Bank, turning east along the northern slopes of George Bligh Bank, Lousy Bank and Bill Bailey's Bank, whereupon the flow splits with ~3 Sv turning northwest towards the Iceland–Faroes Ridge and the remainder continuing east towards and north of the Wyville-Thomson Ridge (WTR to the Scotland slope thereby increasing the Slope Current transport from ~1.5 Sv south of the WTR to 3.5 Sv in the Faroes–Shetland Channel.

  11. Prostate-specific antigen, sexual behavior, and sexually transmitted infections in US men 40–59 years old, 2001–2004: a cross – sectional study

    Directory of Open Access Journals (Sweden)

    Platz Elizabeth A

    2007-10-01

    Full Text Available Abstract Background Sexually transmitted infections (STIs are hypothesized to play a role in the development of prostate cancer, perhaps due to inflammation-induced oncogenesis. We assessed in a nationally representative population of middle-aged men whether sexual behavior indicators for an increased risk of genital infection were associated with serum prostate-specific antigen (PSA concentration, a marker of prostatic disease and inflammation. Results The percentage of men between the ages of 40 and 59 with a PSA ≥ 4.0 ng/ml was 2.6% (95% confidence interval [CI], 1.8% – 3.8%. The percentage of men between the ages of 40 and 59 self-reporting a past diagnosis of genital warts or genital herpes, or a recent diagnosis of gonorrhea or chlamydia is estimated to be 7.3% (95% CI, 6.2% – 8.6%. Men self-reporting that they had had sex without using a condom in the past month had a lower PSA concentration and higher %fPSA than those who did not. There were no associations between any of the other sexual activity or laboratory measures and PSA or %fPSA. Conclusion In this nationally representative sample of middle-aged American men, we did not find consistent evidence for an association between sexual behavior or a history of STIs and PSA levels. Therefore, sexual factors are unlikely to lead to falsely elevated PSA tests in this population. We cannot rule out the role of these factors in causing false positive PSA tests in subgroups of the population that have a higher prevalence of high-risk sexual behavior, and more protracted or recent exposures to these agents.

  12. Predictors of Health-Care Utilization Among Children 6-59 Months of Age in Zambézia Province, Mozambique.

    Science.gov (United States)

    Bayham, Mary; Blevins, Meridith; Lopez, Melanie; Olupona, Omo; González-Calvo, Lazaro; Ndatimana, Elisée; Green, Ann F; Moon, Troy D

    2017-02-08

    Globally, approximately 5.9 million children under 5 years of age died in 2015, a reduction of over 50% since 1990. Millennium Development Goal 4 established the goal of reducing child mortality by two-thirds by 2015. Multiple countries have surpassed this goal; however, regional and within-country inequities exist. We sought to study determinants of health-care utilization among children 6-59 months of age with fever, diarrhea, and respiratory symptoms in Zambézia Province, Mozambique. We conducted a population-based cross-sectional survey of female heads of household between April and May 2014. Mobile teams conducted interviews in 262 enumeration areas, with three distinct districts being oversampled for improved precision. Descriptive statistics and logistic regression using Stata 13.1 and R 3.2.2 were used to examine factors associated with health-care utilization. A total of 2,317 children were evaluated in this study. Mothers' median age was 26 years, whereas child median age was 24 months. The proportion of children reporting fever, diarrhea, or respiratory illness in the prior 30 days was 44%, 22%, and 22%, respectively. Health-care utilization varied with 65% seeking health care for fever, compared with 57% for diarrhea and 25% for respiratory illness. In multivariable logistic regression, the characteristics most associated with health-care utilization across illnesses were delivery of last child at a facility, higher maternal education, and household ownership of a radio. The decision or ability to use health care is a multifaceted behavior swayed by societal norms, values, socioeconomics, and perceived need. Recognizing the predictors of a particular population may offer useful information to increase uptake in health-care services. © The American Society of Tropical Medicine and Hygiene.

  13. Predictors of Health-Care Utilization Among Children 6–59 Months of Age in Zambézia Province, Mozambique

    Science.gov (United States)

    Bayham, Mary; Blevins, Meridith; Lopez, Melanie; Olupona, Omo; González-Calvo, Lazaro; Ndatimana, Elisée; Green, Ann F.; Moon, Troy D.

    2017-01-01

    Globally, approximately 5.9 million children under 5 years of age died in 2015, a reduction of over 50% since 1990. Millennium Development Goal 4 established the goal of reducing child mortality by two-thirds by 2015. Multiple countries have surpassed this goal; however, regional and within-country inequities exist. We sought to study determinants of health-care utilization among children 6–59 months of age with fever, diarrhea, and respiratory symptoms in Zambézia Province, Mozambique. We conducted a population-based cross-sectional survey of female heads of household between April and May 2014. Mobile teams conducted interviews in 262 enumeration areas, with three distinct districts being oversampled for improved precision. Descriptive statistics and logistic regression using Stata 13.1 and R 3.2.2 were used to examine factors associated with health-care utilization. A total of 2,317 children were evaluated in this study. Mothers' median age was 26 years, whereas child median age was 24 months. The proportion of children reporting fever, diarrhea, or respiratory illness in the prior 30 days was 44%, 22%, and 22%, respectively. Health-care utilization varied with 65% seeking health care for fever, compared with 57% for diarrhea and 25% for respiratory illness. In multivariable logistic regression, the characteristics most associated with health-care utilization across illnesses were delivery of last child at a facility, higher maternal education, and household ownership of a radio. The decision or ability to use health care is a multifaceted behavior swayed by societal norms, values, socioeconomics, and perceived need. Recognizing the predictors of a particular population may offer useful information to increase uptake in health-care services. PMID:27821686

  14. Determinants of successful vitamin A supplementation coverage among children aged 6-59 months in thirteen sub-Saharan African countries.

    Science.gov (United States)

    Janmohamed, Amynah; Klemm, Rolf Dw; Doledec, David

    2017-08-01

    Vitamin A supplementation (VAS) for children aged 6-59 months occurs regularly in most sub-Saharan African countries. The present study aimed to explore child, household and delivery platform factors associated with VAS coverage and identify barriers to compliance in thirteen African countries. We pooled data (n ~60 000) from forty-four household coverage surveys and used bivariate and multivariable regression analyses to assess the effects of supplementation strategy, rural v. urban residence, child sex, child age, caregiver education and campaign awareness on child VAS status. Setting/Subjects Primary caregivers of children aged 6-59 months in thirteen countries. Door-to-door distribution resulted in higher VAS coverage than fixed-site plus outreach approaches (91 v. 63 %) and was a significant predictor of supplementation in the adjusted model (OR=19·0; 95 % CI 17·2, 21·1; P<0·001). Having been informed about the campaign was the main predictor of VAS in the door-to-door (OR=6·8; 95 % CI 5·8, 7·9; P<0·001) and fixed-site plus outreach (OR=72·5; 95 % CI 66·6, 78·8; P<0·001) groups. Door-to-door provision of VAS may achieve higher coverage than fixed-site models in the African context. However, the phase-out of door-to-door polio immunization campaigns in most sub-Saharan African countries threatens the main distribution vehicle for VAS. Our findings suggest well-informed communities are key to attaining higher coverage using fixed-site delivery alternatives.

  15. MF59-adjuvanted H5N1 vaccine induces immunologic memory and heterotypic antibody responses in non-elderly and elderly adults.

    Directory of Open Access Journals (Sweden)

    Angelika Banzhoff

    Full Text Available Pathogenic avian influenza virus (H5N1 has the potential to cause a major global pandemic in humans. Safe and effective vaccines that induce immunologic memory and broad heterotypic response are needed.Healthy adults aged 18-60 and > 60 years (n = 313 and n = 173, respectively were randomized (1:1 to receive two primary and one booster injection of 7.5 microg or 15 microg doses of a subunit MF59-adjuvanted H5N1 (A/Vietnam/1194/2004 (clade 1 vaccine. Safety was monitored until 6 months after booster. Immunogenicity was assessed by hemagglutination inhibition (HI, single radial hemolysis (SRH and microneutralization assays (MN. Mild injection-site pain was the most common adverse reaction. No serious adverse events relating to the vaccine were reported. The humoral immune responses to 7.5 microg and 15 microg doses were comparable. The rates for seroprotection (HI>40; SRH>25 mm(2; MN > or = 40 after the primary vaccination ranged 72-87%. Six months after primary vaccination with the 7.5 microg dose, 18% and 21% of non-elderly and elderly adults were seroprotected; rates increased to 90% and 84%, respectively, after the booster vaccination. In the 15 microg group, seroprotection rates among non-elderly and elderly adults increased from 25% and 62% after primary vaccination to 92% and 88% after booster vaccination, respectively. A heterologous immune response to the H5N1/turkey/Turkey/05 strain was elicited after second and booster vaccinations.Both formulations of MF59-adjuvanted influenza H5N1 vaccine were well tolerated. The European Union requirement for licensure for pre-pandemic vaccines was met by the lower dose tested. The presence of cross-reactive antibodies to a clade 2 heterologous strain demonstrates that this vaccine may be appropriate for pre-pandemic programs.(ClinicalTrials.gov NCT00311480.

  16. Production of scandium-44m and scandium-44g with deuterons on calcium-44: cross section measurements and production yield calculations

    Science.gov (United States)

    Duchemin, C.; Guertin, A.; Haddad, F.; Michel, N.; Métivier, V.

    2015-09-01

    HIGHLIGHTS • Production of Sc-44m, Sc-44g and contaminants. • Experimental values determined using the stacked-foil technique. • Thick-Target production Yield (TTY) calculations. • Comparison with the TALYS code version 1.6. Among the large number of radionuclides of medical interest, Sc-44 is promising for PET imaging. Either the ground-state Sc-44g or the metastable-state Sc-44m can be used for such applications, depending on the molecule used as vector. This study compares the production rates of both Sc-44 states, when protons or deuterons are used as projectiles on an enriched Calcium-44 target. This work presents the first set of data for the deuteron route. The results are compared with the TALYS code. The Thick-Target production Yields of Sc-44m and Sc-44g are calculated and compared with those for the proton route for three different scenarios: the production of Sc-44g for conventional PET imaging, its production for the new 3 γ imaging technique developed at the SUBATECH laboratory and the production of a Sc-44m/Sc-44g in vivo generator for antibody labelling.

  17. Art. 59 Abs. 2 S. 1 GG im Lichte von Brexit und IStGH-Austritt. Zur Parlamentarisierung der Kündigung völkerrechtlicher Verträge / Felix Lange

    Index Scriptorium Estoniae

    Lange, Felix

    2017-01-01

    Rahvusvahelistest lepingutest loobumisest ja parlamendi kaasamisest otsustusprotsessi Saksa põhiseaduse artikli 59 tähenduses; Suurbritannia ja Lõuna-Aafrika ülemkohtute lahenditest. Kokkuvõte inglise keeles

  18. Physical and underway data collected aboard the ATLANTIS during cruise AT15-59 in the North Pacific Ocean from 2010-01-04 to 2010-01-13 (NODC Accession 0103915)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC accession 0103915 includes physical and underway data collected aboard the ATLANTIS during cruise AT15-59 in the North Pacific Ocean from 2010-01-04 to...

  19. Multiclonal Outbreak of Klebsiella pneumoniae Producing Extended-Spectrum β-Lactamase CTX-M-2 and Novel Variant CTX-M-59 in a Neonatal Intensive Care Unit in Brazil▿

    Science.gov (United States)

    de Oliveira Garcia, Doroti; Doi, Yohei; Szabo, Dora; Adams-Haduch, Jennifer M.; Vaz, Tânia M. I.; Leite, Daniela; Padoveze, Maria Clara; Freire, Maristela P.; Silveira, Fernanda P.; Paterson, David L.

    2008-01-01

    An outbreak of cephalosporin-resistant Klebsiella pneumoniae occurred in a neonatal intensive care unit in São Paulo, Brazil. Of the 10 pulsotypes identified during the outbreak and follow-up periods, nine produced CTX-M-2 or its new variant CTX-M-59 and one produced SHV-5. blaCTX-M-2/59 genes were located on closely related plasmids that were transferable. PMID:18347108

  20. Riwayat pola asuh, pola makan, asupan zat gizi berhubungan dengan stunting pada anak 24–59 bulan di Biboki Utara, Timor Tengah Utara, Nusa Tenggara Timur

    Directory of Open Access Journals (Sweden)

    Christin Debora Nabuasa

    2016-08-01

    Full Text Available ABSTRACTBackground: Stunting is an indicator of chronic malnutrition that reflects problem of overall social economic condition in the past and as a manifestation of further consequences of the prevalence of low birth weight and undernutrition in children underfive and absence of supreme catch-up growth in the followingyears. Stunting brings impact to physical growth disorder that results in low capacity in working memory, learning memory, visuospatial ability and cognitive function. Low economic condition, rearing pattern, eating pattern, nutrient intake for a long time cause high prevalence of stunting in children underfives. The result of basic health survey 2007 showed the prevalence of stunting at the Province of Nusa Tenggara Timur was 46.7%, in District of Timor Tengah Utara was 59.6% and at Subdistrict of Biboki Utara in two subsequent years were 64.6% and 60.2%.Objectives: To identify association between history of rearing pattern, eating pattern, nutrient intake and stunting in children of 24-59 months in Subdistrict of Biboki Utara District of Timor Tengah Utara Province of Nusa Tenggara Timur.Methods: The study was observational with case control design. Research instrument was questionnaire that was used to identify history of rearing pattern, eating pattern and nutrient intake through recall 4x24 hours subsequently. The study was carried out in Subdistrict of Biboki Utara with subject of the study were children of 24-59 months old involving a total of 152 subjects consisting of 76 children underfive as cases and 76 as control.Results: History of inadequate rearing pattern was 53.9%, eating pattern 55.9%, energy intake 55.9%, protein intake 52.6%, calcium intake 52.0%, infection disease 51.3%, family economy 61.8%, food tenacity 71.7%. The result of bivariate analysis showed variables of history of rearing pattern, eating pattern, nutrient intake, infection disease, family economy had significant association (p<0