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Sample records for sas proc ttest

  1. Using SAS PROC MCMC for Item Response Theory Models

    Science.gov (United States)

    Ames, Allison J.; Samonte, Kelli

    2015-01-01

    Interest in using Bayesian methods for estimating item response theory models has grown at a remarkable rate in recent years. This attentiveness to Bayesian estimation has also inspired a growth in available software such as WinBUGS, R packages, BMIRT, MPLUS, and SAS PROC MCMC. This article intends to provide an accessible overview of Bayesian…

  2. SAS FORMATS: USES AND ABUSES

    Science.gov (United States)

    SAS formats are a very powerful tool. They allow you to display the data in a more readable manner without modifying it. Formats can also be used to group data into categories for use in various procedures like PROC FREQ, PROC TTEST, and PROC MEANS (as a class variable). As ...

  3. PROC LCA: A SAS Procedure for Latent Class Analysis

    Science.gov (United States)

    Lanza, Stephanie T.; Collins, Linda M.; Lemmon, David R.; Schafer, Joseph L.

    2007-01-01

    Latent class analysis (LCA) is a statistical method used to identify a set of discrete, mutually exclusive latent classes of individuals based on their responses to a set of observed categorical variables. In multiple-group LCA, both the measurement part and structural part of the model can vary across groups, and measurement invariance across…

  4. PROC LCA: A SAS Procedure for Latent Class Analysis

    Science.gov (United States)

    Lanza, Stephanie T.; Collins, Linda M.; Lemmon, David R.; Schafer, Joseph L.

    2007-01-01

    Latent class analysis (LCA) is a statistical method used to identify a set of discrete, mutually exclusive latent classes of individuals based on their responses to a set of observed categorical variables. In multiple-group LCA, both the measurement part and structural part of the model can vary across groups, and measurement invariance across…

  5. Conducting Meta-Analysis Using SAS

    CERN Document Server

    Arthur, Winfried; Huffcutt, Allen I; Arthur, Winfred

    2001-01-01

    Conducting Meta-Analysis Using SAS reviews the meta-analysis statistical procedure and shows the reader how to conduct one using SAS. It presents and illustrates the use of the PROC MEANS procedure in SAS to perform the data computations called for by the two most commonly used meta-analytic procedures, the Hunter & Schmidt and Glassian approaches. This book serves as both an operational guide and user's manual by describing and explaining the meta-analysis procedures and then presenting the appropriate SAS program code for computing the pertinent statistics. The practical, step-by-step instru

  6. Traitement des données par le logiciel SAS: introduction au module de base

    OpenAIRE

    Carletti, Isabelle; Prevot, Hugues

    2006-01-01

    Cette note constitue une introduction au module de base SAS. Après un bref aperçu de l'environnement de travail SAS et des principes du langage SAS, les étapes DATA et PROC d'un programme SAS sont exposées en plus en détails.

  7. SAS essentials mastering SAS for data analytics

    CERN Document Server

    Elliott, Alan C

    2015-01-01

    A step-by-step introduction to using SAS® statistical software as a foundational approach to data analysis and interpretation Presenting a straightforward introduction from the ground up, SAS® Essentials: Mastering SAS for Data Analytics, Second Edition illustrates SAS using hands-on learning techniques and numerous real-world examples. Keeping different experience levels in mind, the highly-qualified author team has developed the book over 20 years of teaching introductory SAS courses. Divided into two sections, the first part of the book provides an introduction to data manipulation, st

  8. Planetary Radars Operating Centre PROC

    Science.gov (United States)

    Catallo, C.; Flamini, E.; Seu, R.; Alberti, G.

    2007-12-01

    Planetary exploration by means of radar systems, mainly using Ground Penetrating Radars (GPR) plays an important role in Italy. Numerous scientific international space programs are currently carried out jointly with ESA and NASA by Italian Space Agency, the scientific community and the industry. Three important experiments under Italian leadership ( designed and manufactured by the Italian industry), provided by ASI either as contribution to ESA programs either within a NASA/ASI joint venture framework, are now operating: MARSIS on-board Mars Express, SHARAD on-board Mars Reconnaissance Orbiter and CASSINI Radar on-board Cassini spacecraft. In order to support all the scientific communities, institutional customers and experiment teams operation three Italian dedicated operational centers have been realized, namely SHOC, (Sharad Operating Centre), MOC (Marsis Operating Center) and CASSINI PAD ( Processing Altimetry Data). Each center is dedicated to a single instrument management and control, data processing and distribution. Although they had been conceived to operate autonomously and independently one from each other, synergies and overlaps have been envisaged leading to the suggestion of a unified center, the Planetary Radar Processing Center (PROC). PROC is conceived in order to include the three operational centers, namely SHOC, MOC and CASSINI PAD, either from logistics point of view and from HW/SW capabilities point of view. The Planetary Radar Processing Center shall be conceived as the Italian support facility to the scientific community for on-going and future Italian planetary exploration programs. Therefore, scalability, easy use and management shall be the design drivers. The paper describes how PROC is designed and developed, to allow SHOC, MOC and CASSINI PAD to operate as before, and to offer improved functionalities to increase capabilities, mainly in terms of data exchange, comparison, interpretation and exploitation. Furthermore, in the frame of

  9. SAS for dummies

    CERN Document Server

    McDaniel, Stephen

    2010-01-01

    The fun and easy way to learn to use this leading business intelligence tool Written by an author team who is directly involved with SAS, this easy-to-follow guide is fully updated for the latest release of SAS and covers just what you need to put this popular software to work in your business. SAS allows any business or enterprise to improve data delivery, analysis, reporting, movement across a company, data mining, forecasting, statistical analysis, and more. SAS For Dummies, 2nd Edition  gives you the necessary background on what SAS can do for you and explains how to use the Enterprise Gui

  10. Nyheder i SAS

    DEFF Research Database (Denmark)

    Milhøj, Anders

    2016-01-01

    I sommeren 2015 blev Analytical Produts opgraderet version 14.1, men stadig til Base SAS, version 9.4 sendt på markedet. Denne opdatering til nu Analytical Products 14.1 indeholder opdateringer af de analytiske programpakker indenfor statistik, økonometri, operationsanalyse etc. Disse opdateringer...... er nu løsrevet fra samtidige opdateringer af det samlede SAS-program. Desuden er den gratis SAS-applikation SAS-U opdateret; især er det bemærkelsesværdigt at der via SAS-U nu også stilles procedurer til rådighed for avancerede ikke-modelbaserede tidsrækkeanalyser....

  11. Matrixregning med SAS

    DEFF Research Database (Denmark)

    Andersen, Aage T.; Feilberg, Michael; Milhøj, Anders

    IML i SAS anvendes til matrixberegninger som en integreret del af SAS pakken. Den anvendes typisk til matrixberegninger i tilknytning til andre SAS applikationer, fx kan matricer let dannes ud fra datasæt i SAS. Desuden indeholder IML en række videregående matematiske og statistiske subroutiner......, der ikke findes andre steder i SAS.I bogen gennemgås matrixregning svarende til et indledende matematikkursus ved en højere læreanstalt. Den teoretiske gennemgang understøttes og demonstreres konsekvent med IML programmering, så fokus er på praktiske anvendelser af matricer....

  12. SAS and Sata SSDs

    Science.gov (United States)

    Yasarapu, S.

    This chapter focuses on the different types of solid state drives. The chapter details the differences between consumer and enterprise solid state drives and also details the differences between SAS and SATA solid state drive and what lies ahead for SATA and SAS protocols for SSDs.

  13. Data analysis using SAS

    CERN Document Server

    Peng, Chao-Ying Joanne

    2008-01-01

    "Peng provides an excellent overview of data analysis using the powerful statistical software package SAS. This book is quite appropriate as a self-placed tutorial for researchers, as well as a textbook or supplemental workbook for data analysis courses such as statistics or research methods. Peng provides detailed coverage of SAS capabilities using step-by-step procedures and includes numerous comprehensive graphics and figures, as well as SAS printouts. Readers do not need a background in computer science or programming. Includes numerous examples in education, health sciences, and business.

  14. SAS for dummies

    CERN Document Server

    McDaniel, Stephen

    2010-01-01

    The fun and easy way to learn to use this leading business intelligence tool Written by an author team who is directly involved with SAS, this easy-to-follow guide is fully updated for the latest release of SAS and covers just what you need to put this popular software to work in your business. SAS allows any business or enterprise to improve data delivery, analysis, reporting, movement across a company, data mining, forecasting, statistical analysis, and more. SAS For Dummies, 2nd Edition  gives you the necessary background on what SAS can do for you and explains how to use the Enterprise Guide. SAS provides statistical and data analysis tools to help you deal with all kinds of data: operational, financial, performance, and more Places special emphasis on Enterprise Guide and other analytical tools, covering all commonly used features Covers all commonly used features and shows you the practical applications you can put to work in your business Explores how to get various types of data into the software and...

  15. Sidste nyt fra SAS

    DEFF Research Database (Denmark)

    Milhøj, Anders

    2014-01-01

    I juli 2013 blev version 9.4 af SAS sendt på markedet. Denne release indeholdt ikke mange nye faciliteter indenfor statistik, økonometri, operationsanalyse etc, men alligevel er der vigtige aspekter at forholde sig til. Ved årsskiftet 2013/2014 er der siden kommet en opdatering af de analytiske...... programpakker for statistik, økonometri, operationsanalyse etc uden en samtidig opdatering af det samlede SAS-program. Denne opdatering kaldes Analytical Products 13.1 og er en væsentlig opdatering fra version 12, der i første version kom i august 2012....

  16. Nyheder i SAS

    DEFF Research Database (Denmark)

    Milhøj, Anders

    2015-01-01

    I juli 2013 blev version 9.4 af SAS sendt på markedet. Denne release indeholdt ikke i sig selv mange nye faciliteter indenfor statistik, økonometri, operations-analyse etc, men alligevel er der vigtige aspekter at forholde sig til. Ved årsskiftet 2013/2014 kom opdateringen Analytical Products 13.......1 af de analytiske programpakker for statistik, økonometri, operationsanalyse etc uden en samtidig opdatering af det samlede SAS-program. Denne opdatering er siden fulgt op med en yderligere opdatering 13.2 i august 2014....

  17. Differences in ODS formatting for HTML with Proc Print and Proc Report

    Science.gov (United States)

    While proc print is a terrific tool for data checking and data summary, proc report is similar to, but more powerful because it can do some basic calculations or statistics and data can be broken more effectively into manageable fields. The ODS procedure can produce HTML files from either procedure...

  18. An enhanced Planetary Radar Operating Centre (PROC)

    Science.gov (United States)

    Catallo, C.

    2010-12-01

    Planetary exploration by means of radar systems, mainly using GPRs is an important role of Italy and numerous scientific international space programs are carried out jointly with ESA and NASA by Italian Space Agency, the scientific community and the industry. Three experiments under Italian leadership ( designed and manufactured by the Italian industry) provided by ASI within a NASA/ESA/ASI joint venture framework are successfully operating: MARSIS on-board MEX, SHARAD on-board MRO and CASSINI Radar on-board Cassini spacecraft: the missions have been further extended . Three dedicated operational centers, namely SHOC, (Sharad Operating Centre), MOC (Marsis Operating Center) and CASSINI PAD are operating from the missions beginning to support all the scientific communities, institutional customers and experiment teams operation Each center is dedicated to a single instrument management and control, data processing and distribution and even if they had been conceived to operate autonomously and independently one from each other, synergies and overlaps have been envisaged leading to the suggestion of a unified center, the Planetary Radar Processing Center (PROC). In order to harmonize operations either from logistics point of view and from HW/SW capabilities point of view PROC is designed and developed for offering improved functionalities to increase capabilities, mainly in terms of data exchange, comparison, interpretation and exploitation. PROC is, therefore, conceived as the Italian support facility to the scientific community for on-going and future Italian planetary exploration programs, such as Europa-Jupiter System Mission (EJSM) The paper describes how the new PROC is designed and developed, to allow SHOC, MOC and CASSINI PAD to operate as before, and to offer improved functionalities to increase capabilities, mainly in terms of data exchange, comparison, interpretation and exploitation aiding scientists to increase their knowledge in the field of surface

  19. SASWeave: Literate Programming Using SAS

    Directory of Open Access Journals (Sweden)

    Russell V. Lenth

    2007-05-01

    Full Text Available SASweave is a collection of scripts that allow one to embed SAS code into a LATEX document, and automatically incorporate the results as well. SASweave is patterned after Sweave, which does the same thing for code written in R. In fact, a document may contain both SAS and R code. Besides the convenience of being able to easily incorporate SAS examples in a document, SASweave facilitates the concept of “literate programming”: having code, documentation, and results packaged together. Among other things, this helps to ensure that the SAS output in the document is in concordance with the code.

  20. Time Series Modelling using Proc Varmax

    DEFF Research Database (Denmark)

    Milhøj, Anders

    2007-01-01

    In this paper it will be demonstrated how various time series problems could be met using Proc Varmax. The procedure is rather new and hence new features like cointegration, testing for Granger causality are included, but it also means that more traditional ARIMA modelling as outlined by Box & Je...... & Jenkins is performed in a more modern way using the computer resources which are now available...

  1. SASWeave: Literate Programming Using SAS

    DEFF Research Database (Denmark)

    Lenth, Russell V; Højsgaard, Søren

    2007-01-01

    the convenience of being able to easily incorporate SAS examples in a document, SASweave facilitates the concept of "literate programming": having code, documentation, and results packaged together. Among other things, this helps to ensure that the SAS output in the document is in concordance with the code...

  2. SASWeave: Literate Programming Using SAS

    DEFF Research Database (Denmark)

    Lenth, Russell V; Højsgaard, Søren

    2007-01-01

    SASweave is a collection of scripts that allow one to embed SAS code into a LATEX document, and automatically incorporate the results as well. SASweave is patterned after Sweave, which does the same thing for code written in R. In fact, a document may contain both SAS and R code. Besides the conv...

  3. Applied medical statistics using SAS

    CERN Document Server

    Der, Geoff

    2012-01-01

    ""Each chapter in the book is well laid out, contains examples with SAS code, and ends with a concise summary. The chapters in the book contain the right level of information to use SAS to apply different statistical methods. … a good overview of how to apply in SAS 9.3 the many possible statistical analysis methods.""-Caroline Kennedy, Takeda Development Centre Europe Ltd., Statistical Methods for Medical Research, 2015""… a well-organized and thorough exploration of broad coverage in medical statistics. The book is an excellent reference of statistical methods

  4. Nye grafiske muligheder i SAS

    DEFF Research Database (Denmark)

    Milhøj, Anders

    2009-01-01

    Den vigtigste i SAS version 9.2 indenfor grafik er mulighederne for at producere dokumentationsgrafik i mange statistiske procedurer. Det drejer sig især om grafikker til modelkontrol, fx. residualdiagrammer, influensplot, normalfraktildiagrammer for residualerne etc.......Den vigtigste i SAS version 9.2 indenfor grafik er mulighederne for at producere dokumentationsgrafik i mange statistiske procedurer. Det drejer sig især om grafikker til modelkontrol, fx. residualdiagrammer, influensplot, normalfraktildiagrammer for residualerne etc....

  5. Development and validation of a smartphone addiction scale (SAS.

    Directory of Open Access Journals (Sweden)

    Min Kwon

    Full Text Available OBJECTIVE: The aim of this study was to develop a self-diagnostic scale that could distinguish smartphone addicts based on the Korean self-diagnostic program for Internet addiction (K-scale and the smartphone's own features. In addition, the reliability and validity of the smartphone addiction scale (SAS was demonstrated. METHODS: A total of 197 participants were selected from Nov. 2011 to Jan. 2012 to accomplish a set of questionnaires, including SAS, K-scale, modified Kimberly Young Internet addiction test (Y-scale, visual analogue scale (VAS, and substance dependence and abuse diagnosis of DSM-IV. There were 64 males and 133 females, with ages ranging from 18 to 53 years (M = 26.06; SD = 5.96. Factor analysis, internal-consistency test, t-test, ANOVA, and correlation analysis were conducted to verify the reliability and validity of SAS. RESULTS: Based on the factor analysis results, the subscale "disturbance of reality testing" was removed, and six factors were left. The internal consistency and concurrent validity of SAS were verified (Cronbach's alpha = 0.967. SAS and its subscales were significantly correlated with K-scale and Y-scale. The VAS of each factor also showed a significant correlation with each subscale. In addition, differences were found in the job (p<0.05, education (p<0.05, and self-reported smartphone addiction scores (p<0.001 in SAS. CONCLUSIONS: This study developed the first scale of the smartphone addiction aspect of the diagnostic manual. This scale was proven to be relatively reliable and valid.

  6. Applications of Proc ESM in SAS® 9.2

    DEFF Research Database (Denmark)

    Milhøj, Anders

    2010-01-01

    modern time series analysis than its successor Proc Forecast as the smoothing parameters are estimated and not fixed. Moreover Proc ESM has facilities to accumulate transactional data in various ways and has a broad flexibility in transforming the time series to be forecasted....

  7. Applications of Proc ESM in SAS® 9.2

    DEFF Research Database (Denmark)

    Milhøj, Anders

    2010-01-01

    In this paper the various facilities of Proc ESM in SAS® 9.2 will be demonstrated using a dataset of 87789 registrations of the speed of passing cars on a highway near Copenhagen. Proc ESM (for Exponential Smoothing Models) was introduced in SAS® version 9.2 as a procedure corresponding to more...

  8. PSHREG: a SAS macro for proportional and nonproportional subdistribution hazards regression.

    Science.gov (United States)

    Kohl, Maria; Plischke, Max; Leffondré, Karen; Heinze, Georg

    2015-02-01

    We present a new SAS macro %pshreg that can be used to fit a proportional subdistribution hazards model for survival data subject to competing risks. Our macro first modifies the input data set appropriately and then applies SAS's standard Cox regression procedure, PROC PHREG, using weights and counting-process style of specifying survival times to the modified data set. The modified data set can also be used to estimate cumulative incidence curves for the event of interest. The application of PROC PHREG has several advantages, e.g., it directly enables the user to apply the Firth correction, which has been proposed as a solution to the problem of undefined (infinite) maximum likelihood estimates in Cox regression, frequently encountered in small sample analyses. Deviation from proportional subdistribution hazards can be detected by both inspecting Schoenfeld-type residuals and testing correlation of these residuals with time, or by including interactions of covariates with functions of time. We illustrate application of these extended methods for competing risk regression using our macro, which is freely available at: http://cemsiis.meduniwien.ac.at/en/kb/science-research/software/statistical-software/pshreg, by means of analysis of a real chronic kidney disease study. We discuss differences in features and capabilities of %pshreg and the recent (January 2014) SAS PROC PHREG implementation of proportional subdistribution hazards modelling.

  9. SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae.

    OpenAIRE

    Xu, E. Y; S. Kim; Rivier, D H

    1999-01-01

    Sir2p, Sir3p, Sir4p, and the core histones form a repressive chromatin structure that silences transcription in the regions near telomeres and at the HML and HMR cryptic mating-type loci in Saccharomyces cerevisiae. Null alleles of SAS4 and SAS5 suppress silencing defects at HMR; therefore, SAS4 and SAS5 are negative regulators of silencing at HMR. This study revealed that SAS4 and SAS5 contribute to silencing at HML and the telomeres, indicating that SAS4 and SAS5 are positive regulators of ...

  10. When "t"-Tests or Wilcoxon-Mann-Whitney Tests Won't Do

    Science.gov (United States)

    McElduff, Fiona; Cortina-Borja, Mario; Chan, Shun-Kai; Wade, Angie

    2010-01-01

    "t"-Tests are widely used by researchers to compare the average values of a numeric outcome between two groups. If there are doubts about the suitability of the data for the requirements of a "t"-test, most notably the distribution being non-normal, the Wilcoxon-Mann-Whitney test may be used instead. However, although often applied, both tests may…

  11. MLGA: A SAS Macro to Compute Maximum Likelihood Estimators via Genetic Algorithms

    Directory of Open Access Journals (Sweden)

    Francisco Juretig

    2015-08-01

    Full Text Available Nonlinear regression is usually implemented in SAS either by using PROC NLIN or PROC NLMIXED. Apart from the model structure, initial values need to be specified for each parameter. And after some convergence criteria are fulfilled, the second order conditions need to be analyzed. But numerical problems are expected to appear in case the likelihood is nearly discontinuous, has plateaus, multiple maxima, or the initial values are distant from the true parameter estimates. The usual solution consists of using a grid, and then choosing the set of parameters reporting the highest log-likelihood. However, if the amount of parameters or grid points is large, the computational burden will be excessive. Furthermore, there is no guarantee that, as the number of grid points increases, an equal or better set of points will be found. Genetic algorithms can overcome these problems by replicating how nature optimizes its processes. The MLGA macro is presented; it solves a maximum likelihood estimation problem under normality through PROC GA, and the resulting values can later be used as the starting values in SAS nonlinear procedures. As will be demonstrated, this macro can avoid the usual trial and error approach that is needed when convergence problems arise. Finally, it will be shown how this macro can deal with complicated restrictions involving multiple parameters.

  12. What's new in SAS 9.3

    DEFF Research Database (Denmark)

    Milhøj, Anders

    2012-01-01

    I foråret 2010 blev den ny SAS version SAS 9.22 lanceret som en opdatering af SAS 9.2, med væsentlige nye muligheder for netop statistik. Her i sommeren 2011 blev version 9.3 så lanceret med endnu flere nyskabelser i både generel performance og specielt indenfor statistik, økonometri og...

  13. SAS : kosheljok ili proshtshai, Estonian Air!

    Index Scriptorium Estoniae

    2008-01-01

    Lennukompanii SAS saatis Eesti valitsusele kirja, milles teatab, et on nõus raskustesse sattunud Estonian Airile lisainvesteeringuid tegema ainult siis, kui valitsus müüb SAS-ile oma osaluse. Ettevõtjate, parlamendiliige Marko Mihkelsoni ja ministrite arvamusi

  14. A SAS IML Macro for Loglinear Smoothing

    Science.gov (United States)

    Moses, Tim; von Davier, Alina

    2011-01-01

    Polynomial loglinear models for one-, two-, and higher-way contingency tables have important applications to measurement and assessment. They are essentially regarded as a smoothing technique, which is commonly referred to as loglinear smoothing. A SAS IML (SAS Institute, 2002a) macro was created to implement loglinear smoothing according to…

  15. The SAS-3 delayed command system

    Science.gov (United States)

    Hoffman, E. J.

    1975-01-01

    To meet the requirements arising from the increased complexity of the power, attitude control and telemetry systems, a full redundant high-performance control section with delayed command capability was designed for the Small Astronomy Satellite-3 (SAS-3). The relay command system of SAS-3 is characterized by 56 bystate relay commands, with capability for handling up to 64 commands in future versions. The 'short' data command service of SAS-1 and SAS-2 consisting of shifting 24-bit words to two users was expanded to five users and augmented with a 'long load' data command service (up to 4080 bits) used to program the telemetry system and the delayed command subsystem. The inclusion of a delayed command service ensures a program of up to 30 relay or short data commands to be loaded for execution at designated times. The design and system operation of the SAS-3 command section are analyzed, with special attention given to the delayed command subsystem.

  16. The SAS-3 programmable telemetry system

    Science.gov (United States)

    Peterson, M. R.

    1975-01-01

    Basic concept, system design and operation principles of the telemetry system developed for the Small Astronomy Satellite-3 (SAS-3) are analyzed. The concept of programmable format selected for the SAS-3 represents an optical combination of the fixed format system of SAS-1 and SAS-2, and the adaptive format concept. The programmable telemetry system permits a very wide range of changes in the data sampling order by a ground control station, depending on the experimental requirements, so that the maximal amount of useful data can be returned from orbit. The programmable system also allows the data format to differ from one spacecraft to another without changing hardware. Attention is given to the command requirements and redundancy of the SAS-3 telemetry system.

  17. t-tests, non-parametric tests, and large studies—a paradox of statistical practice?

    Directory of Open Access Journals (Sweden)

    Fagerland Morten W

    2012-06-01

    Full Text Available Abstract Background During the last 30 years, the median sample size of research studies published in high-impact medical journals has increased manyfold, while the use of non-parametric tests has increased at the expense of t-tests. This paper explores this paradoxical practice and illustrates its consequences. Methods A simulation study is used to compare the rejection rates of the Wilcoxon-Mann-Whitney (WMW test and the two-sample t-test for increasing sample size. Samples are drawn from skewed distributions with equal means and medians but with a small difference in spread. A hypothetical case study is used for illustration and motivation. Results The WMW test produces, on average, smaller p-values than the t-test. This discrepancy increases with increasing sample size, skewness, and difference in spread. For heavily skewed data, the proportion of p Conclusions Non-parametric tests are most useful for small studies. Using non-parametric tests in large studies may provide answers to the wrong question, thus confusing readers. For studies with a large sample size, t-tests and their corresponding confidence intervals can and should be used even for heavily skewed data.

  18. Use of "t"-Test and ANOVA in Career-Technical Education Research

    Science.gov (United States)

    Rojewski, Jay W.; Lee, In Heok; Gemici, Sinan

    2012-01-01

    Use of t-tests and analysis of variance (ANOVA) procedures in published research from three scholarly journals in career and technical education (CTE) during a recent 5-year period was examined. Information on post hoc analyses, reporting of effect size, alpha adjustments to account for multiple tests, power, and examination of assumptions…

  19. Comparison of the results of T-Test from different versions of Epi Info

    Institute of Scientific and Technical Information of China (English)

    Junke Tang; Jinliang Zhu

    2005-01-01

    Objective: To take advantage of Epi Info to manage and analyze disease data. Methods: After selecting the living examples for independent sample T-Test, Epi Info 5.00, 5.01a(Chinese), 6.00, 6.04 b, 6.04 d, 2000, 2002(Chinese)were used to do the independent sample T-Test on the two living examples. Then, Intercooled Stata7, Microsoft Excel(2002) and SPSS 10.0 for Windows were used to verify the results. Results: The statistical results from the Epi Info 5.00, 5.01a(Chinese) and 6.00 were the same while that from Epi Info 6.04 b, 6.04 d, 2000,2002 (Chinese), Intercooled Stata7, Microsoft Excel(2002) and SPSS 10.0 for Windows were identical In independent sample T-Test,. But the former result is different with the latter. Conclusion: There was an error in the result of T-Test from Epi Info 6.00 and former versions. Thus, it's important to be alert to select the versions of Epi Info to manage and analyze disease data. On the other hand, it's also quite pivotal to distinguish the adopted Epi Info versions when referring to the articles ane use the statistical results.

  20. A Spreadsheet Tool for Learning the Multiple Regression F-Test, T-Tests, and Multicollinearity

    Science.gov (United States)

    Martin, David

    2008-01-01

    This note presents a spreadsheet tool that allows teachers the opportunity to guide students towards answering on their own questions related to the multiple regression F-test, the t-tests, and multicollinearity. The note demonstrates approaches for using the spreadsheet that might be appropriate for three different levels of statistics classes,…

  1. Extending and Enhancing SAS (Static Analysis Suite)

    CERN Document Server

    Ho, David

    2016-01-01

    The Static Analysis Suite (SAS) is an open-source software package used to perform static analysis on C and C++ code, helping to ensure safety, readability and maintainability. In this Summer Student project, SAS was enhanced to improve ease of use and user customisation. A straightforward method of integrating static analysis into a project at compilation time was provided using the automated build tool CMake. The process of adding checkers to the suite was streamlined and simplied by developing an automatic code generator. To make SAS more suitable for continuous integration, a reporting mechanism summarising results was added. This suitability has been demonstrated by inclusion of SAS in the Future Circular Collider Software nightly build system. Scalability of the improved package was demonstrated by using the tool to analyse the ROOT code base.

  2. Key Performance Indicators for SAS Flights

    OpenAIRE

    Arhall, Johanna; Cox, Emmie

    2013-01-01

    Revenue management is a thoroughly researched field of study and it is widely used in several different industries. The Revenue Management Department at the airline SAS (Scandinavian Airline System) serves to maximise the profit of the company’s flights. At their disposal they have a number of tools, which use KPIs (Key Performance Indicators) as a measurement. The KPIs are used in prognosis to determine future initiatives, and to analyse and verify results. SAS does not know if the KPIs they...

  3. SAS doctors career progression survey 2013.

    Science.gov (United States)

    Oroz, Carlos; Sands, Lorna R; Lee, John

    2016-03-01

    We conducted a national survey of Staff, Associate Specialists and Specialty (SAS) doctors working in sexual health clinics in the UK in 2013 in order to explore their career progression. The aim of the survey was to assess SAS doctors' experience in passing through the thresholds and to gather information about the adherence by SAS doctors and employers to the terms and conditions of service laid out by the new 2008 contract. Out of 185 responders, whom the authors estimate comprise 34% of the total workforce, 159 were on the new contract. Of those, most SAS doctors were women (84%), the majority (67%) worked less than nine programmed activities per week; only a few had intentions to join the consultant grade (15%), and a considerable minority (26%) were older than 54 years of age and likely to retire in the next ten years. The survey showed that most participating SAS doctors had undergone appraisal in the previous 15 months (90%), most had a job planning discussion (83%) with their employer and most had some allocated time for supporting professional activities (86%). However, a significant minority had no appraisal (10%), no job planning discussion (17%) and had no allocated supporting professional activities (14%), which allows time for career development in the specialty. Most SAS doctors, who had the opportunity, had progressed through the thresholds automatically (88%); some experienced difficulties in passing (8%) and only a few did not pass (4%). SAS doctors must ensure that they work together with their employer in order to improve adherence to the terms and conditions of service of the contract, which allow for career progression and benefit both the individual doctors and ultimately service provision.

  4. The SAS-3 X-ray observatory

    Science.gov (United States)

    Mayer, W. F.

    1975-01-01

    The experiment section of the Small Astronomy Satellite-3 (SAS-3) launched in May 1975 is an X-ray observatory intended to determine the location of bright X-ray sources to an accuracy of 15 arc-seconds; to study a selected set of sources over a wide energy range, from 0.1 to 55 keV, while performing very specific measurements of the spectra and time variability of known X-ray sources; and to monitor the sky continuously for X-ray novae, flares, and unexpected phenomena. The improvements in SAS-3 spacecraft include a clock accurate to 1 part in 10 billion, rotatable solar panels, a programmable data format, and improved nutation damper, a delayed command system, improved magnetic trim and azimuth control systems. These improvements enable SAS-3 to perform three-axis stabilized observations of any point on the celestial sphere at any time of the year. The description of the experiment section and the SAS-3 operation is followed by a synopsis of scientific results obtained from the observations of X-ray sources, such as Vela X-1 (supposed to be an accreting neutron star), a transient source of hard X-ray (less than 36 min in duration) detected by SAS-3, the Crab Nebula pulsar, the Perseus cluster of galaxies, and the Vela supernova remnant.

  5. SAS-2 galactic gamma ray results, 1

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.; Bignami, G. F.; Lamb, R. C.; Oegelman, H.; Oezel, M. E.; Tuemer, T.

    1976-01-01

    Continuing analysis of the data from the SAS-2 high energy gamma-ray experiment has produced an improved picture of the sky at photon energies above 35 MeV. On a large scale, the diffuse emission from the galactic plane is the dominant feature observed by SAS-2. This galactic plane emission is most intense between galactic longitude 310 and 45 deg, corresponding to a region within 7kpc of the galactic center. Within the high-intensity region, SAS-2 observes peaks around galactic longitudes 315 deg, 330 deg, 345 deg, 0 deg, and 35 deg. These peaks appear to be correlated with such galactic features and components as molecular hydrogen, atomic hydrogen, magnetic fields, cosmic ray concentrations, and photon fields.

  6. Statistical hypothesis testing with SAS and R

    CERN Document Server

    Taeger, Dirk

    2014-01-01

    A comprehensive guide to statistical hypothesis testing with examples in SAS and R When analyzing datasets the following questions often arise:Is there a short hand procedure for a statistical test available in SAS or R?If so, how do I use it?If not, how do I program the test myself? This book answers these questions and provides an overview of the most commonstatistical test problems in a comprehensive way, making it easy to find and performan appropriate statistical test. A general summary of statistical test theory is presented, along with a basicdescription for each test, including the

  7. A two-sample Bayesian t-test for microarray data

    Directory of Open Access Journals (Sweden)

    Dimmic Matthew W

    2006-03-01

    Full Text Available Abstract Background Determining whether a gene is differentially expressed in two different samples remains an important statistical problem. Prior work in this area has featured the use of t-tests with pooled estimates of the sample variance based on similarly expressed genes. These methods do not display consistent behavior across the entire range of pooling and can be biased when the prior hyperparameters are specified heuristically. Results A two-sample Bayesian t-test is proposed for use in determining whether a gene is differentially expressed in two different samples. The test method is an extension of earlier work that made use of point estimates for the variance. The method proposed here explicitly calculates in analytic form the marginal distribution for the difference in the mean expression of two samples, obviating the need for point estimates of the variance without recourse to posterior simulation. The prior distribution involves a single hyperparameter that can be calculated in a statistically rigorous manner, making clear the connection between the prior degrees of freedom and prior variance. Conclusion The test is easy to understand and implement and application to both real and simulated data shows that the method has equal or greater power compared to the previous method and demonstrates consistent Type I error rates. The test is generally applicable outside the microarray field to any situation where prior information about the variance is available and is not limited to cases where estimates of the variance are based on many similar observations.

  8. SAS wave experiment on board Magion 4

    Directory of Open Access Journals (Sweden)

    J. Błęcki

    Full Text Available A short description of the SAS (subsatellite analyser of spectra wave experiment on board the Magion-4 subsatellite is given. We present first measurements of the magnetic-field fluctuations in the frequency range 32–2000 Hz obtained in the magnetotail during the disturbed period at the magnetopause and in the polar cusp.

  9. Beijing, the SAS Gateway to China

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Scandinavian Airlines has launched the direct route from Stockholm to Beijing.China's Foreign Trade had an interview with Mr. Lars Lindgren,CEO of Scandinavian Airlines International (SAS).He pointed out that they expect to see that all across Scandinavia will be opened to China,and before long Beijing will become Scandinavian Airlines' gateway to China. The follows are the interview.

  10. Estimating relative risks for common outcome using PROC NLP.

    Science.gov (United States)

    Yu, Binbing; Wang, Zhuoqiao

    2008-05-01

    In cross-sectional or cohort studies with binary outcomes, it is biologically interpretable and of interest to estimate the relative risk or prevalence ratio, especially when the response rates are not rare. Several methods have been used to estimate the relative risk, among which the log-binomial models yield the maximum likelihood estimate (MLE) of the parameters. Because of restrictions on the parameter space, the log-binomial models often run into convergence problems. Some remedies, e.g., the Poisson and Cox regressions, have been proposed. However, these methods may give out-of-bound predicted response probabilities. In this paper, a new computation method using the SAS Nonlinear Programming (NLP) procedure is proposed to find the MLEs. The proposed NLP method was compared to the COPY method, a modified method to fit the log-binomial model. Issues in the implementation are discussed. For illustration, both methods were applied to data on the prevalence of microalbuminuria (micro-protein leakage into urine) for kidney disease patients from the Diabetes Control and Complications Trial. The sample SAS macro for calculating relative risk is provided in the appendix.

  11. The SAS-3 power and thermal systems

    Science.gov (United States)

    Sullivan, R. M.; Hogrefe, A. F.; Brenza, P. T.

    1975-01-01

    Solar array configurations of the SAS-3 are described: a configuration with two sets of coplanar panels in the horizontal and two others in the vertical position, and two other configurations with either four horizontal or four vertical sets of panels. The nickel-cadmium battery of the power subsystem is described in detail, with emphasis on voltage limits and charge-discharge characteristics. The characteristic of 'solar-only' operation in the case of damage to the battery is discussed. The thermal subsystem of SAS-3 is considered, with discussions of thermal design criteria and the thermal environment. Temperature is controlled by using internal thermal louvers that regulate the rate at which the heat load from electronic equipment is transmitted to the outer surface for dumping to space.

  12. Fitting polytomous Rasch models in SAS

    DEFF Research Database (Denmark)

    Christensen, Karl Bang

    2006-01-01

    The item parameters of a polytomous Rasch model can be estimated using marginal and conditional approaches. This paper describes how this can be done in SAS (V8.2) for three item parameter estimation procedures: marginal maximum likelihood estimation, conditional maximum likelihood estimation......, and pairwise conditional estimation. The use of the procedures for extensions of the Rasch model is also discussed. The accuracy of the methods are evaluated using a simulation study....

  13. Design and analysis of experiments with SAS

    CERN Document Server

    Lawson, John

    2010-01-01

    IntroductionStatistics and Data Collection Beginnings of Statistically Planned Experiments Definitions and Preliminaries Purposes of Experimental Design Types of Experimental Designs Planning Experiments Performing the Experiments Use of SAS SoftwareCompletely Randomized Designs with One Factor Introduction Replication and Randomization A Historical Example Linear Model for Completely Randomized Design (CRD) Verifying Assumptions of the Linear Model Analysis Strategies When Assumptions Are Violated Determining the Number of Replicates Comparison of Treatments after the F-TestFactorial Designs

  14. Simultaneous critical values for $t$-tests in very high dimensions

    CERN Document Server

    Cao, Hongyuan; 10.3150/10-BEJ272

    2011-01-01

    This article considers the problem of multiple hypothesis testing using $t$-tests. The observed data are assumed to be independently generated conditional on an underlying and unknown two-state hidden model. We propose an asymptotically valid data-driven procedure to find critical values for rejection regions controlling the $k$-familywise error rate ($k$-FWER), false discovery rate (FDR) and the tail probability of false discovery proportion (FDTP) by using one-sample and two-sample $t$-statistics. We only require a finite fourth moment plus some very general conditions on the mean and variance of the population by virtue of the moderate deviations properties of $t$-statistics. A new consistent estimator for the proportion of alternative hypotheses is developed. Simulation studies support our theoretical results and demonstrate that the power of a multiple testing procedure can be substantially improved by using critical values directly, as opposed to the conventional $p$-value approach. Our method is applie...

  15. Colombian Safe Guide S.A.S

    OpenAIRE

    2012-01-01

    Colombian Safe Guide S.A.S. es una compañía de servicios de asesoramiento y acompañamiento a los visitantes extranjeros que vienen a la ciudad de Bogotá. Funciona a través de una página web, que facilitan a sus clientes la obtención de todos los servicios necesarios durante su estadía, en un solo lugar. El principal objetivo es proporcionar nuevas alternativas de servicios de asesoramiento, capitalizando la compañía bajo el cumplimiento del objetivo y cuota del mercado propuesta por la compañ...

  16. The SAS-3 attitude control system

    Science.gov (United States)

    Mobley, F. F.; Konigsberg, R.; Fountain, G. H.

    1975-01-01

    SAS-3 uses a reaction wheel to provide torque to control the spin rate. If the wheel speed becomes too great or too small, it must be restored to its nominal rate by momentum dumping which is done by magnetic torquing against the earth's magnetic field by the satellite's magnetic coils. A small rate-integrating gyro is used to sense the spin rate so that closed loop control of the spin rate can be achieved. These various systems are described in detail including the reaction wheel system, the gyro system, along with control modes (spin rate control and the star lock mode).

  17. SAS-Expander and Its Realization%SAS-Expander及其实现

    Institute of Scientific and Technical Information of China (English)

    王宇

    2009-01-01

    SAS(Serial Attached SCSI)即串行SCSI技术,是一种磁盘连接技术.而Expander本质上就是SAS交换机,可以将多个SAS连接到有限数量的主机端口上.这里主要介绍了通过MAX-IM公司的VSC7154实现SAS-Expander磁盘阵列柜.此阵列柜机构部件依据SBB规范实现.

  18. Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly.

    Science.gov (United States)

    Lettman, Molly M; Wong, Yao Liang; Viscardi, Valeria; Niessen, Sherry; Chen, Sheng-Hong; Shiau, Andrew K; Zhou, Huilin; Desai, Arshad; Oegema, Karen

    2013-05-13

    Assembly of SAS-6 dimers to form the centriolar cartwheel requires the ZYG-1/Plk4 kinase. Here, we show that ZYG-1 recruits SAS-6 to the mother centriole independently of its kinase activity; kinase activity is subsequently required for cartwheel assembly. We identify a direct interaction between ZYG-1 and the SAS-6 coiled coil that explains its kinase activity-independent function in SAS-6 recruitment. Perturbing this interaction, or the interaction between an adjacent segment of the SAS-6 coiled coil and SAS-5, prevented SAS-6 recruitment and cartwheel assembly. SAS-6 mutants with alanine substitutions in a previously described ZYG-1 target site or in 37 other residues, either phosphorylated by ZYG-1 in vitro or conserved in closely related nematodes, all supported cartwheel assembly. We propose that ZYG-1 binding to the SAS-6 coiled coil recruits the SAS-6-SAS-5 complex to the mother centriole, where a ZYG-1 kinase activity-dependent step, whose target is unlikely to be SAS-6, triggers cartwheel assembly.

  19. Meta-Analysis of Ordinal Data and Its Solution by SAS%有序数据的Meta分析方法及SAS实现

    Institute of Scientific and Technical Information of China (English)

    张天嵩; 熊茜

    2012-01-01

    目的 介绍有序数据的Meta分析方法及其在SAS软件的实现.方法 以实例说明,采用两步法:第一步,基于累积比数模型,采用SAS中的GENMOD过程计算产生每个研究的效应量及其标准误;第二步,采用固定效应模型和随机效应模型以SAS中的MIXED过程进行经典Meta分析.结果 固定效应和随机效应模型Meta分析结果显示,汇总比值比及95%可信区间均为2.853 9(2.106 4,3.864 8).结论 对于有序数据,可以应用SAS中的GENMOD过程和MIXED过程进行Meta分析.%Objective To introduce methodology for undertaking a meta-analysis on ordinal data and its realization in SAS. Methods It was illustrated on an example data by using two-step method. In the first step, it was calculated treatment effect and its standard error for an individual study by using PROC GENMOD in SAS based on cumulative odds models; in the second step, a classical meta-analysis was proposed for fixed and random effect model by using PROC MIXED in SAS. Results Results from the traditional meta-analysis of summary odds ratio and its 95% CI were same 2.853 9(2.106 4,3.864 8) for fixed and random effect model. Conclusions The procedure SAS PROC GENMOD and MIXED were utilized to undertake a meta-analysis on ordinal data.

  20. Composites reinforcement by rods: a SAS study

    Energy Technology Data Exchange (ETDEWEB)

    Urban, V. [ESRF, BP220, 38043 Grenoble Cedex (France); Botti, A.; Pyckhout-Hintzen, W.; Richter, D. [IFF-Forschungszentrum Juelich, 52425 Juelich (Germany); Straube, E. [University of Halle, FB Physik, 06099 Halle (Germany)

    2002-07-01

    The mechanical properties of composites are governed by size, shape and dispersion degree of so-called reinforcing particles. Polymeric fillers based on thermodynamically driven microphase separation of block copolymers offer the opportunity to study a model system of controlled rod-like filler particles. We chose a triblock copolymer (PBPSPB) and carried out SAS measurements with both X-rays and neutrons, in order to characterize separately the hard phase and the cross-linked PB matrix. The properties of the material depend strongly on the way that stress is carried and transferred between the soft matrix and the hard fibers. The failure of the strain-amplification concept and the change of topological contributions to the free energy and scattering factor have to be addressed. In this respect the composite shows a similarity to a two-network system, i.e. interpenetrating rubber and rod-like filler networks. (orig.)

  1. Composites reinforcement by rods a SAS study

    CERN Document Server

    Urban, V; Pyckhout-Hintzen, W; Richter, D; Straube, E

    2002-01-01

    The mechanical properties of composites are governed by size, shape and dispersion degree of so-called reinforcing particles. Polymeric fillers based on thermodynamically driven microphase separation of block copolymers offer the opportunity to study a model system of controlled rod-like filler particles. We chose a triblock copolymer (PBPSPB) and carried out SAS measurements with both X-rays and neutrons, in order to characterize separately the hard phase and the cross-linked PB matrix. The properties of the material depend strongly on the way that stress is carried and transferred between the soft matrix and the hard fibers. The failure of the strain-amplification concept and the change of topological contributions to the free energy and scattering factor have to be addressed. In this respect the composite shows a similarity to a two-network system, i.e. interpenetrating rubber and rod-like filler networks. (orig.)

  2. Regression modeling methods, theory, and computation with SAS

    CERN Document Server

    Panik, Michael

    2009-01-01

    Regression Modeling: Methods, Theory, and Computation with SAS provides an introduction to a diverse assortment of regression techniques using SAS to solve a wide variety of regression problems. The author fully documents the SAS programs and thoroughly explains the output produced by the programs.The text presents the popular ordinary least squares (OLS) approach before introducing many alternative regression methods. It covers nonparametric regression, logistic regression (including Poisson regression), Bayesian regression, robust regression, fuzzy regression, random coefficients regression,

  3. SAS and R data management, statistical analysis, and graphics

    CERN Document Server

    Kleinman, Ken

    2014-01-01

    An Up-to-Date, All-in-One Resource for Using SAS and R to Perform Frequent TasksThe first edition of this popular guide provided a path between SAS and R using an easy-to-understand, dictionary-like approach. Retaining the same accessible format, SAS and R: Data Management, Statistical Analysis, and Graphics, Second Edition explains how to easily perform an analytical task in both SAS and R, without having to navigate through the extensive, idiosyncratic, and sometimes unwieldy software documentation. The book covers many common tasks, such as data management, descriptive summaries, inferentia

  4. Relative and absolute reliability of a modified agility T-test and its relationship with vertical jump and straight sprint.

    Science.gov (United States)

    Sassi, Radhouane Haj; Dardouri, Wajdi; Yahmed, Mohamed Haj; Gmada, Nabil; Mahfoudhi, Mohamed Elhedi; Gharbi, Zied

    2009-09-01

    The aims of this study were to evaluate the reliability of a modified agility T-test (MAT) and to examine its relationship to the free countermovement jump (FCMJ) and the 10-m straight sprint (10mSS). In this new version, we preserved the same nature of displacement of the T-test but we reduced the total distance to cover. A total of 86 subjects (34 women: age = 22.6 +/- 1.4 years; weight = 63.7 +/- 10.2 kg; height = 1.65 +/- 0.05 m; body mass index = 23.3 +/- 3.3 kg x m(-2) and 52 men: age = 22.4 +/- 1.5 years; weight = 68.7 +/- 8.0 kg; height = 1.77 +/- 0.06 m; body mass index = 22.0 +/- 2.0 kg x m(-2)) performed MAT, T-test, FCMJ, and 10mSS. Our results showed no difference between test-retest MAT scores. Intraclass reliability of the MAT was greater than 0.90 across the trials (0.92 and 0.95 for women and men, respectively). The mean difference (bias) +/- the 95% limits of agreement was 0.03 +/- 0.37 seconds for women and 0.03 +/- 0.33 seconds for men. MAT was correlated to the T-test (r = 0.79, p women and men, respectively). Significant correlations were found between both MAT and FCMJ, and MAT and 10mSS for women (r = -0.47, p men. These results indicate that MAT is a reliable test to assess agility. The weak relationship between MAT and strength and straight speed suggests that agility requires other determinants of performance as coordination. Considering that field sports generally include sprints with change direction over short distance, MAT seems to be more specific than the T-test when assessing agility.

  5. Adaptive beamforming for low frequency SAS imagery and bathymetry

    NARCIS (Netherlands)

    Hayes, M.P.; Hunter, A.J.

    2012-01-01

    Synthetic aperture side-scan sonar (SAS) is a mature technology for high-resolution sea floor imaging [1]. Interferometric synthetic aperture sonars (InSAS) use additional hydrophones in a vertical array for bathymetric mapping [2]. This has created high-resolution bathymetry in deep water environme

  6. Adaptive beamforming for low frequency SAS imagery and bathymetry

    NARCIS (Netherlands)

    Hayes, M.P.; Hunter, A.J.

    2012-01-01

    Synthetic aperture side-scan sonar (SAS) is a mature technology for high-resolution sea floor imaging [1]. Interferometric synthetic aperture sonars (InSAS) use additional hydrophones in a vertical array for bathymetric mapping [2]. This has created high-resolution bathymetry in deep water

  7. Hotelli Radisson SAS mantra : jah, ma saan! / Kai Vare

    Index Scriptorium Estoniae

    Vare, Kai, 1968-

    2004-01-01

    Radisson SAS hotell Tallinnas on kliendirahulolu-uuringute järgi keti hotellide seas esimeste hulgas. Hotelli direktor Kaido Ojaperv ja müügijuht Ann-Kai Tõrs Radisson SAS-i standarditest, kliendi sajaprotsendilise rahulolu tagamise põhimõtetest, personali valikust, koolitusest. Kommenteerib Sandra Dimitrovich

  8. SAS-6 coiled-coil structure and interaction with SAS-5 suggest a regulatory mechanism in C. elegans centriole assembly.

    Science.gov (United States)

    Qiao, Renping; Cabral, Gabriela; Lettman, Molly M; Dammermann, Alexander; Dong, Gang

    2012-11-14

    The centriole is a conserved microtubule-based organelle essential for both centrosome formation and cilium biogenesis. Five conserved proteins for centriole duplication have been identified. Two of them, SAS-5 and SAS-6, physically interact with each other and are codependent for their targeting to procentrioles. However, it remains unclear how these two proteins interact at the molecular level. Here, we demonstrate that the short SAS-5 C-terminal domain (residues 390-404) specifically binds to a narrow central region (residues 275-288) of the SAS-6 coiled coil. This was supported by the crystal structure of the SAS-6 coiled-coil domain (CCD), which, together with mutagenesis studies, indicated that the association is mediated by synergistic hydrophobic and electrostatic interactions. The crystal structure also shows a periodic charge pattern along the SAS-6 CCD, which gives rise to an anti-parallel tetramer. Overall, our findings establish the molecular basis of the specific interaction between SAS-5 and SAS-6, and suggest that both proteins individually adopt an oligomeric conformation that is disrupted upon the formation of the hetero-complex to facilitate the correct assembly of the nine-fold symmetric centriole.

  9. An improved predictive association rule based classifier using gain ratio and T-test for health care data diagnosis

    Indian Academy of Sciences (India)

    M Nandhini; S N Sivanandam

    2015-09-01

    Health care data diagnosis is a significant task that needs to be executed precisely, which requires much experience and domain-knowledge. Traditional symptoms-based disease diagnosis may perhaps lead to false presumptions. In recent times, Associative Classification (AC), the combination of association rule mining and classification has received attention in health care applications which desires maximum accuracy. Though several AC techniques exist, they lack in generating quality rules for building efficient associative classifier. This paper aims to enhance the accuracy of the existing CPAR (Classification based on Predictive Association Rule) algorithm by generating quality rules using Gain Ratio. Mostly, health care applications deal with high dimensional datasets. Existence of high dimensions causes unfair estimates in disease diagnosis. Dimensionality reduction is commonly applied as a preprocessing step before classification task to improve classifier accuracy. It eliminates redundant and insignificant dimensions by keeping good ones without information loss. In this work, dimensionality reductions by T-test and reduct sets (or simply reducts) are performed as preprocessing step before CPAR and CPAR using Gain Ratio (CPAR-GR) algorithms. An investigation was also performed to determine the impact of T-test and reducts on CPAR and CPAR-GR. This paper synthesizes the existing work carried out in AC, and also discusses the factors that influence the performance of CPAR and CPAR-GR. Experiments were conducted using six health care datasets from UCI machine learning repository. Based on the experiments, CPAR-GR with T-test yields better classification accuracy than CPAR.

  10. SAS and R data management, statistical analysis, and graphics

    CERN Document Server

    Kleinman, Ken

    2009-01-01

    An All-in-One Resource for Using SAS and R to Carry out Common TasksProvides a path between languages that is easier than reading complete documentationSAS and R: Data Management, Statistical Analysis, and Graphics presents an easy way to learn how to perform an analytical task in both SAS and R, without having to navigate through the extensive, idiosyncratic, and sometimes unwieldy software documentation. The book covers many common tasks, such as data management, descriptive summaries, inferential procedures, regression analysis, and the creation of graphics, along with more complex applicat

  11. Substrate Activity Screening (SAS) and Related Approaches in Medicinal Chemistry.

    Science.gov (United States)

    Gladysz, Rafaela; Lambeir, Anne-Marie; Joossens, Jurgen; Augustyns, Koen; Van der Veken, Pieter

    2016-03-04

    Substrate activity screening (SAS) was presented a decade ago by Ellman and co-workers as a straightforward methodology for the identification of fragment-sized building blocks for enzyme inhibitors. Ever since, SAS and variations derived from it have been successfully applied to the discovery of inhibitors of various families of enzymatically active drug targets. This review covers key achievements and challenges of SAS and related methodologies, including the modified substrate activity screening (MSAS) approach. Special attention is given to the kinetic and thermodynamic aspects of these methodologies, as a thorough understanding thereof is crucial for successfully transforming the identified fragment-sized hits into potent inhibitors.

  12. Usual Dietary Intakes: SAS Macros for the NCI Method

    Science.gov (United States)

    SAS macros are currently available to facilitate modeling of a single dietary component, whether consumed daily or episodically; ratios of two dietary components that are consumed nearly every day; multiple dietary components, whether consumed daily or episodically.

  13. Breast Cancer Risk Assessment SAS Macro (Gail Model)

    Science.gov (United States)

    A SAS macro (commonly referred to as the Gail Model) that projects absolute risk of invasive breast cancer according to NCI’s Breast Cancer Risk Assessment Tool (BCRAT) algorithm for specified race/ethnic groups and age intervals.

  14. Islandlased tahavad SAS-i Skandinaavia turult kukutada / Mikk Salu

    Index Scriptorium Estoniae

    Salu, Mikk, 1975-

    2006-01-01

    Islandlastele kuuluv investeerimisfirma FL Grupp koondab lennufirmasid, et haarata liidrirolli Põhjala lennunduses. Lisad: Island; Islandi rikkaim mees; Uus põlvkond. Diagrammid: Islandi lennuärimehed versus SAS

  15. Structure of the SAS-6 cartwheel hub from Leishmania major.

    Science.gov (United States)

    van Breugel, Mark; Wilcken, Rainer; McLaughlin, Stephen H; Rutherford, Trevor J; Johnson, Christopher M

    2014-01-01

    Centrioles are cylindrical cell organelles with a ninefold symmetric peripheral microtubule array that is essential to template cilia and flagella. They are built around a central cartwheel assembly that is organized through homo-oligomerization of the centriolar protein SAS-6, but whether SAS-6 self-assembly can dictate cartwheel and thereby centriole symmetry is unclear. Here we show that Leishmania major SAS-6 crystallizes as a 9-fold symmetric cartwheel and provide the X-ray structure of this assembly at a resolution of 3.5 Å. We furthermore demonstrate that oligomerization of Leishmania SAS-6 can be inhibited by a small molecule in vitro and provide indications for its binding site. Our results firmly establish that SAS-6 can impose cartwheel symmetry on its own and indicate how this process might occur mechanistically in vivo. Importantly, our data also provide a proof-of-principle that inhibition of SAS-6 oligomerization by small molecules is feasible. DOI: http://dx.doi.org/10.7554/eLife.01812.001.

  16. A SAS Package for Logistic Two-Phase Studies

    Directory of Open Access Journals (Sweden)

    Walter Schill

    2014-04-01

    Full Text Available Two-phase designs, in which for a large study a dichotomous outcome and partial or proxy information on risk factors is available, whereas precise or complete measurements on covariates have been obtained only in a stratified sub-sample, extend the standard case-control design and have been proven useful in practice. The application of two-phase designs, however, seems to be hampered by the lack of appropriate, easy-to-use software. This paper introduces sas-twophase-package, a collection of SAS-macros, to fulfill this task. sas-twophase-package implements weighted likelihood, pseudo likelihood and semi- parametric maximum likelihood estimation via the EM algorithm and via profile likelihood in two-phase settings with dichotomous outcome and a given stratification.

  17. Social Anxiety Scale for Adolescents (SAS-A) Short Form.

    Science.gov (United States)

    Nelemans, Stefanie A; Meeus, Wim H J; Branje, Susan J T; Van Leeuwen, Karla; Colpin, Hilde; Verschueren, Karine; Goossens, Luc

    2017-01-01

    In this study, we examined the longitudinal measurement invariance of a 12-item short version of the Social Anxiety Scale for Adolescents (SAS-A) in two 4-year longitudinal community samples ( Nsample 1 = 815, Mage T1 = 13.38 years; Nsample 2 = 551, Mage T1 = 14.82 years). Using confirmatory factor analyses, we found strict longitudinal measurement invariance for the three-factor structure of the SAS-A across adolescence, across samples, and across gender. Some developmental changes in social anxiety were found from early to mid-adolescence, as well as gender differences across adolescence. These findings suggest that the short version of the SAS-A is a developmentally appropriate instrument that can be used effectively to examine adolescent social anxiety development.

  18. SAS-2 galactic gamma-ray results. 1: Diffuse emission

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.; Bignami, G. F.; Lamb, R. C.; Oegelman, H.; Oezel, M. E.; Tuemer, T.

    1977-01-01

    Continuing analysis of the data from the SAS-2 high energy gamma ray experiment has produced an improved picture of the sky at photon energies above 35 MeV. On a large scale, the diffuse emission from the galactic plane is the dominant feature observed by SAS-2. This galactic plane emission is most intense between galactic longitudes 310 deg and 45 deg, corresponding to a region within 7 kpc of the galactic center. Within the high-intensity region, SAS-2 observes peaks around galactic longitudes 315, 330, 345, 0, and 35 deg. These peaks appear to be correlated with galactic features and components such as molecular hydrogen, atomic hydrogen, magnetic fields, cosmic-ray concentrations, and photon fields.

  19. Want independent validation and assurance? Ask for a SAS-70.

    Science.gov (United States)

    Boutin, Christopher C

    2008-08-01

    The AICPA's Statement on Auditing Standards No.70, Service Organizations addresses CPA audits of service providers conducted to verify that a provider has adequate controls over its operations. Hospitals should request a SAS-70, the report produced by such an audit, from all of their third-party service providers. SAS-70s can be issued for a specific date or for a six-month period, and they typically consist of three sections: a CPA opinion, a description of controls, and information about the design of the controls.

  20. Observations of A0620-00 by SAS-3

    Science.gov (United States)

    Bradt, H.; Matilsky, T.

    1976-01-01

    The transient X-ray source A0620-00 was observed by the SAS-3 group with the SAS-3 X-ray observatory. At maximum X-ray luminosity limits of 2% were placed on periodic variations from 0.2 ms - 2,000 sec. A precise position was obtained with the rotating modulation collimator. This led directly to radio and optical identification by groups at the NRAO, Arecibo, and McGraw Hill Observatories. The low energy (0.15-0.9 keV) system was pointed at the source, and a spectrum was derived. Hardness ratios are presented, as well as detailed light curves.

  1. Distribution of the two-sample t-test statistic following blinded sample size re-estimation.

    Science.gov (United States)

    Lu, Kaifeng

    2016-05-01

    We consider the blinded sample size re-estimation based on the simple one-sample variance estimator at an interim analysis. We characterize the exact distribution of the standard two-sample t-test statistic at the final analysis. We describe a simulation algorithm for the evaluation of the probability of rejecting the null hypothesis at given treatment effect. We compare the blinded sample size re-estimation method with two unblinded methods with respect to the empirical type I error, the empirical power, and the empirical distribution of the standard deviation estimator and final sample size. We characterize the type I error inflation across the range of standardized non-inferiority margin for non-inferiority trials, and derive the adjusted significance level to ensure type I error control for given sample size of the internal pilot study. We show that the adjusted significance level increases as the sample size of the internal pilot study increases. Copyright © 2016 John Wiley & Sons, Ltd.

  2. A Modified T-test Feature Selection Method and Its Application on the HapMap Genotype Data

    Institute of Scientific and Technical Information of China (English)

    Nina Zhou; Lipo Wang

    2007-01-01

    Single nucleotide polymorphisms (SNPs) are genetic variations that determine the differences between any two unrelated individuals. Various population groups can be distinguished from each other using SNPs. For instance, the HapMap dataset has four population groups with about ten million SNPs. For more insights on human evolution, ethnic variation, and population assignment, we propose to find out which SNPs are significant in determining the population groups and then to classify different populations using these relevant SNPs as input features. In this study, we developed a modified t-test ranking measure and applied it to the HapMap genotype data. Firstly, we rank all SNPs in comparison with other feature importance measures including F-statistics and the informativeness for assignment. Secondly, we select different numbers of the most highly ranked SNPs as the input to a classifier, such as the support vector machine, so as to find the best feature subset corresponding to the best classification accuracy. Experimental results showed that the proposed method is very effective in finding SNPs that are significant in determining the population groups, with reduced computational burden and better classification accuracy.

  3. SAS Radisson esitab Tallinnale väljakutse / Tõnis Arnover

    Index Scriptorium Estoniae

    Arnover, Tõnis, 1952-

    2000-01-01

    Tallinna Radisson SAS hotelli juht T. Bodin on kindel, et suudab pakkuda tipphotellile kohast teenindus. Vt. samas Mägus, Feliks. Hinnasõda hotellide vahel jääb ära. Ilmunud ka: Delovõje Vedomosti 1. nov. lk. 20-21

  4. Tubulin nucleotide status controls Sas-4-dependent pericentriolar material recruitment.

    Science.gov (United States)

    Gopalakrishnan, Jayachandran; Chim, Yiu-Cheung Frederick; Ha, Andrew; Basiri, Marcus L; Lerit, Dorothy A; Rusan, Nasser M; Avidor-Reiss, Tomer

    2012-08-01

    Regulated centrosome biogenesis is required for accurate cell division and for maintaining genome integrity. Centrosomes consist of a centriole pair surrounded by a protein network known as pericentriolar material (PCM). PCM assembly is a tightly regulated, critical step that determines the size and capability of centrosomes. Here, we report a role for tubulin in regulating PCM recruitment through the conserved centrosomal protein Sas-4. Tubulin directly binds to Sas-4; together they are components of cytoplasmic complexes of centrosomal proteins. A Sas-4 mutant, which cannot bind tubulin, enhances centrosomal protein complex formation and has abnormally large centrosomes with excessive activity. These results suggest that tubulin negatively regulates PCM recruitment. Whereas tubulin-GTP prevents Sas-4 from forming protein complexes, tubulin-GDP promotes it. Thus, the regulation of PCM recruitment by tubulin depends on its GTP/GDP-bound state. These results identify a role for tubulin in regulating PCM recruitment independent of its well-known role as a building block of microtubules. On the basis of its guanine-bound state, tubulin can act as a molecular switch in PCM recruitment.

  5. A SAS Interface for Bayesian Analysis with WinBUGS

    Science.gov (United States)

    Zhang, Zhiyong; McArdle, John J.; Wang, Lijuan; Hamagami, Fumiaki

    2008-01-01

    Bayesian methods are becoming very popular despite some practical difficulties in implementation. To assist in the practical application of Bayesian methods, we show how to implement Bayesian analysis with WinBUGS as part of a standard set of SAS routines. This implementation procedure is first illustrated by fitting a multiple regression model…

  6. A SAS/IML algorithm for an exact permutation test

    Directory of Open Access Journals (Sweden)

    Neuhäuser, Markus

    2009-03-01

    Full Text Available An algorithm written in SAS/IML is presented that can perform an exact permutation test for a two-sample comparison. All possible permutations are considered. The Baumgartner-Weiß-Schindler statistic is exemplarily used as the test statistic for the permutation test.

  7. SAS- Semantic Annotation Service for Geoscience resources on the web

    Science.gov (United States)

    Elag, M.; Kumar, P.; Marini, L.; Li, R.; Jiang, P.

    2015-12-01

    There is a growing need for increased integration across the data and model resources that are disseminated on the web to advance their reuse across different earth science applications. Meaningful reuse of resources requires semantic metadata to realize the semantic web vision for allowing pragmatic linkage and integration among resources. Semantic metadata associates standard metadata with resources to turn them into semantically-enabled resources on the web. However, the lack of a common standardized metadata framework as well as the uncoordinated use of metadata fields across different geo-information systems, has led to a situation in which standards and related Standard Names abound. To address this need, we have designed SAS to provide a bridge between the core ontologies required to annotate resources and information systems in order to enable queries and analysis over annotation from a single environment (web). SAS is one of the services that are provided by the Geosematnic framework, which is a decentralized semantic framework to support the integration between models and data and allow semantically heterogeneous to interact with minimum human intervention. Here we present the design of SAS and demonstrate its application for annotating data and models. First we describe how predicates and their attributes are extracted from standards and ingested in the knowledge-base of the Geosemantic framework. Then we illustrate the application of SAS in annotating data managed by SEAD and annotating simulation models that have web interface. SAS is a step in a broader approach to raise the quality of geoscience data and models that are published on the web and allow users to better search, access, and use of the existing resources based on standard vocabularies that are encoded and published using semantic technologies.

  8. A SAS-6-like protein suggests that the Toxoplasma conoid complex evolved from flagellar components.

    Science.gov (United States)

    de Leon, Jessica Cruz; Scheumann, Nicole; Beatty, Wandy; Beck, Josh R; Tran, Johnson Q; Yau, Candace; Bradley, Peter J; Gull, Keith; Wickstead, Bill; Morrissette, Naomi S

    2013-07-01

    SAS-6 is required for centriole biogenesis in diverse eukaryotes. Here, we describe a novel family of SAS-6-like (SAS6L) proteins that share an N-terminal domain with SAS-6 but lack coiled-coil tails. SAS6L proteins are found in a subset of eukaryotes that contain SAS-6, including diverse protozoa and green algae. In the apicomplexan parasite Toxoplasma gondii, SAS-6 localizes to the centriole but SAS6L is found above the conoid, an enigmatic tubulin-containing structure found at the apex of a subset of alveolate organisms. Loss of SAS6L causes reduced fitness in Toxoplasma. The Trypanosoma brucei homolog of SAS6L localizes to the basal-plate region, the site in the axoneme where the central-pair microtubules are nucleated. When endogenous SAS6L is overexpressed in Toxoplasma tachyzoites or Trypanosoma trypomastigotes, it forms prominent filaments that extend through the cell cytoplasm, indicating that it retains a capacity to form higher-order structures despite lacking a coiled-coil domain. We conclude that although SAS6L proteins share a conserved domain with SAS-6, they are a functionally distinct family that predates the last common ancestor of eukaryotes. Moreover, the distinct localization of the SAS6L protein in Trypanosoma and Toxoplasma adds weight to the hypothesis that the conoid complex evolved from flagellar components.

  9. CTTITEM: SAS macro and SPSS syntax for classical item analysis.

    Science.gov (United States)

    Lei, Pui-Wa; Wu, Qiong

    2007-08-01

    This article describes the functions of a SAS macro and an SPSS syntax that produce common statistics for conventional item analysis including Cronbach's alpha, item difficulty index (p-value or item mean), and item discrimination indices (D-index, point biserial and biserial correlations for dichotomous items and item-total correlation for polytomous items). These programs represent an improvement over the existing SAS and SPSS item analysis routines in terms of completeness and user-friendliness. To promote routine evaluations of item qualities in instrument development of any scale, the programs are available at no charge for interested users. The program codes along with a brief user's manual that contains instructions and examples are downloadable from suen.ed.psu.edu/-pwlei/plei.htm.

  10. Anatomy of the TAMA SAS seismic attenuation system

    CERN Document Server

    Marka, S; Ando, M; Bertolini, A; Cella, G; DeSalvo, R; Fukushima, M; Iida, Y; Jacquier, F; Kawamura, S; Nishi, Y; Numata, K; Sannibale, V; Somiya, K; Takahashi, R; Tariq, H; Tsubono, K; Ugas, J; Viboud, N; Wang Chen Yang; Yamamoto, H; Yoda, T

    2002-01-01

    The TAMA SAS seismic attenuation system was developed to provide the extremely high level of seismic isolation required by the next generation of interferometric gravitational wave detectors to achieve the desired sensitivity at low frequencies. Our aim was to provide good performance at frequencies above approx 10 Hz, while utilizing only passive subsystems in the sensitive frequency band of the TAMA interferometric gravitational wave detectors. The only active feedback is relegated below 6 Hz and it is used to damp the rigid body resonances of the attenuation chain. Simulations, based on subsystem performance characterizations, indicate that the system can achieve rms mirror residual motion measured in a few tens of nanometres. We will give a brief overview of the subsystems and point out some of the characterization results, supporting our claims of achieved performance. SAS is a passive, UHV compatible and low cost system. It is likely that extremely sensitive experiments in other fields will also profit ...

  11. SAS/QC在统计质量管理中的功能与应用

    Institute of Scientific and Technical Information of China (English)

    钟英莲

    2008-01-01

    在统计教学与实践中,对SAS系统的开发应用较多的是SAS/BASE、SAS/STAT、SAS/ETS等软件,而对于SAS/QC软件的开发应用尚属少见。本文将概括性地介绍SAS/QC软件在质量管理中的功能和作用,通过案例介绍SAS/QC在质量控制中的具体应用。

  12. Genome sequencing and annotation of Proteus sp. SAS71

    Directory of Open Access Journals (Sweden)

    Samy Selim

    2015-12-01

    Full Text Available We report draft genome sequence of Proteus sp. strain SAS71, isolated from water spring in Aljouf region, Saudi Arabia. The draft genome size is 3,037,704 bp with a G + C content of 39.3% and contains 6 rRNA sequence (single copies of 5S, 16S & 23S rRNA. The genome sequence can be accessed at DDBJ/EMBL/GenBank under the accession no. LDIU00000000.

  13. Combination of functional MRI with SAS and MRA

    Energy Technology Data Exchange (ETDEWEB)

    Sumida, Masayuki; Takeshita, Shinichirou; Kutsuna, Munenori; Akimitsu, Tomohide; Arita, Kazunori; Kurisu, Kaoru [Hiroshima Univ. (Japan). School of Medicine

    1999-02-01

    For presurgical diagnosis of brain surface, combination of functional MRI (fMRI) with the MR angiography was examined. This method could visualize brain bay, convolution and vein as index of surface. Five normal adults (male, mean age: 28-year-old) and 7 patients with brain tumor on the main locus to surface (male: 4, female: 3, mean age: 52.3-year-old) were studied. fMRI was performed by SPGR method (TR 70, TE 40, flip angle 60, one slice, thickness 10 mm, FOV 20 cm, matrix 128 x 128). The brain surface was visualized by SAS (surface anatomy scanning). SAS was performed by FSE method (TR 6000, TE 200, echo train 16, thickness 20 mm, slice 3, NEX 2). Cortical veins near superior sagittal sinus were visualized by MRA with 2D-TOF method (TR 50, TE 20, flip angle 60, thickness 2 mm, slice 28, NEX 1). These images were superimposed and functional image of peripheral sensorimotor region was evaluated anatomically. In normal adults, high signal was visualized at another side of near sensorimotor region at 8 of 10 sides. All high signal area of fMRI agreed with cortical vein near sensorimotor region that was visualized by MRA. In patients with brain tumor, signal was visualized at another side of sensorimotor region of tumor without 2 cases with palsy. In another side of tumor, signal of fMRI was visualized in 5 of 7 cases. The tumor was visualized as opposite low signal field in SAS. Locational relation between tumor and brain surface and brain function was visualized distinctly by combination of MRA, SAS and MRA. This method could become useful for presurgical diagnosis. (K.H.)

  14. Quality assurance management plan (QAPP) special analytical support (SAS)

    Energy Technology Data Exchange (ETDEWEB)

    LOCKREM, L.L.

    1999-05-20

    It is the policy of Special Analytical Support (SAS) that the analytical aspects of all environmental data generated and processed in the laboratory, subject to the Environmental Protection Agency (EPA), U.S. Department of Energy or other project specific requirements, be of known and acceptable quality. It is the intention of this QAPP to establish and assure that an effective quality controlled management system is maintained in order to meet the quality requirements of the intended use(s) of the data.

  15. Implementing the Law of Sines to solve SAS triangles

    CERN Document Server

    Zelator, Konstantine

    2010-01-01

    By "solving a triangle", one refers to determining the three sidelengths and the three angles, based on given information.Depending on the specific information, one or more triangles may satisfy the requirements of the given information.In the SAS case, two of sidelengths are given, as well as the angle contained by the two sides.According to Euclidean Geometry, such a triangle must be unique. In reference [1], and pretty much in standard trigonometry and precalculus texts,the Law of Cosines is employed in solving a SAS triangle. In this work we use an alternative approach by using the Law of Cosines.In Section 2, we list some basic trigonometric identities and in Section 3 we prove a lemma which is used in Section4. In Section4, we demonstrate the use of the Law of Sines in solving an SAS triangle. In Section 5 we offer three examples in detail; the last one being more general in nature.

  16. SPSS and SAS programming for the testing of mediation models.

    Science.gov (United States)

    Dudley, William N; Benuzillo, Jose G; Carrico, Mineh S

    2004-01-01

    Mediation modeling can explain the nature of the relation among three or more variables. In addition, it can be used to show how a variable mediates the relation between levels of intervention and outcome. The Sobel test, developed in 1990, provides a statistical method for determining the influence of a mediator on an intervention or outcome. Although interactive Web-based and stand-alone methods exist for computing the Sobel test, SPSS and SAS programs that automatically run the required regression analyses and computations increase the accessibility of mediation modeling to nursing researchers. To illustrate the utility of the Sobel test and to make this programming available to the Nursing Research audience in both SAS and SPSS. The history, logic, and technical aspects of mediation testing are introduced. The syntax files sobel.sps and sobel.sas, created to automate the computation of the regression analysis and test statistic, are available from the corresponding author. The reported programming allows the user to complete mediation testing with the user's own data in a single-step fashion. A technical manual included with the programming provides instruction on program use and interpretation of the output. Mediation modeling is a useful tool for describing the relation between three or more variables. Programming and manuals for using this model are made available.

  17. ¿Es un sistema financiero menos procíclico una meta alcanzable?

    OpenAIRE

    Goodhart, Charles

    2011-01-01

    La banca y las finanzas son inherentemente procíclicas, una condición exacerbada por la combinación de Basilea II y la contabilidad a valor de mercado (mark-to-market accounting), por lo que se requiere crear políticas macroprudenciales anticíclicas. Esta fragilidad se vio intensificada por la reducción en la liquidez bancaria (mayor dependencia en fondos de segundo piso) y el cambio organizacional de sociedades generales a sociedades anónimas abiertas. Algunos comentaristas han visto como so...

  18. Usual Dietary Intakes: SAS Macros for Fitting Multivariate Measurement Error Models & Estimating Multivariate Usual Intake Distributions

    Science.gov (United States)

    The following SAS macros can be used to create a multivariate usual intake distribution for multiple dietary components that are consumed nearly every day or episodically. A SAS macro for performing balanced repeated replication (BRR) variance estimation is also included.

  19. REddyProc: Enabling researchers to process Eddy-Covariance data

    Science.gov (United States)

    Wutzler, Thomas; Moffat, Antje; Migliavacca, Mirco; Knauer, Jürgen; Menzer, Olaf; Sickel, Kerstin; Reichstein, Markus

    2017-04-01

    Analysing Eddy-Covariance measurements involves extensive processing, which puts technical labour to researchers. There is a need to overcome difficulties in data processing associated with deploying, adapting and using existing software and online tools. We tackled that need by developing the REddyProc package in the open source cross-platform language R that provides standard processing routines for reading half-hourly files from different formats, including from the recently released FLUXNET 2015 dataset, uStar threshold estimation and associated uncertainty, gap-filling, flux partitioning (both night-time or daytime based), and visualization of results. Although different in some features, the package mimics the online tool that has been extensively used by many users and site Principal Investigators (PIs) in the last years, and available on the website of the Max Planck Institute for Biogeochemistry. Generally, REddyProc results are statistically equal to results based on the state-of the art tools. The provided routines can be easily installed, configured, used, and integrated with further analysis. Hence the eddy covariance community will benefit from using the provided package allowing easier integration of standard processing with extended analysis. This complements activities by AmeriFlux, ICOS, NEON, and other regional networks for developing codes for standardized data processing of multiple sites in FLUXNET.

  20. SAS-macros for estimation and prediction in an model of the electricity consumption

    DEFF Research Database (Denmark)

    1998-01-01

    SAS-macros for estimation and prediction in an model of the electricity consumption'' is a large collection of SAS-macros for handling a model of the electricity consumption in the Eastern Denmark. The macros are installed at Elkraft, Ballerup.......SAS-macros for estimation and prediction in an model of the electricity consumption'' is a large collection of SAS-macros for handling a model of the electricity consumption in the Eastern Denmark. The macros are installed at Elkraft, Ballerup....

  1. A Tool that Uses the SAS (registered trademark) PRX Functions to Fix Delimited Text Files

    Science.gov (United States)

    2015-07-07

    Article 3. DATES COVERED (From – To) Dec 2014 – Apr 2015 4. TITLE AND SUBTITLE A Tool that Uses the SAS® PRX Functions to Fix Delimited Text Files 5a...Guide® project that uses the SAS PRX functions to import, fix, and export a delimited text file. This fixed file can then be easily imported and...sas, perl, prx , prx functions, sas enterprise guide, sas eg, prxmatch, prxchange 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT SAR

  2. The SAS Education Value-Added Assessment System (SAS[R] EVAAS[R]) in the Houston Independent School District (HISD): Intended and Unintended Consequences

    Science.gov (United States)

    Amrein-Beardsley, Audrey; Collins, Clarin

    2012-01-01

    The SAS Educational Value-Added Assessment System (SAS[R] EVAAS[R]) is the most widely used value-added system in the country. It is also self-proclaimed as "the most robust and reliable" system available, with its greatest benefit to help educators improve their teaching practices. This study critically examined the effects of SAS[R] EVAAS[R] as…

  3. 面向对象的SAS/AF程序设计语言的研究%Research on Object-Oriented Programming with SAS/AF Language

    Institute of Scientific and Technical Information of China (English)

    陈宇术

    2001-01-01

    This paper aims at introducing object-oriented program language using SAS/AF with the concepts of OOA and OOD.And it also discusses how to achieve these concepts in SAS/AF language.%本文结合面向对象分析(OOA)与面向对象设计(OOD)介绍了面向对象的SAS/AF程序语言及探讨了面向对象的理念在SAS/AF中的实现。

  4. Olev Schults : SAS vajab Estonian Airi rahvusliku lennufirmana / Olev Schults ; interv. Andres Reimer

    Index Scriptorium Estoniae

    Schults, Olev

    2008-01-01

    Estonian Airi nõukogu esimees vastab küsimustele, kas SAS arendas Läti airBalticut Estonian SAS-i arvel, mis mõte on rahvuslikul lennukompaniil, kui riik ei tohi seda finantseerida, kuidas mõjutab investorite meeleolu SAS-i Eestis tabanud poliitikute kriitika tulv

  5. %HPGLIMMIX: A High-Performance SAS Macro for GLMM Estimation

    Directory of Open Access Journals (Sweden)

    Liang Xie

    2014-06-01

    Full Text Available Generalized linear mixed models (GLMMs comprise a class of widely used statistical tools for data analysis with fixed and random effects when the response variable has a conditional distribution in the exponential family. GLMM analysis also has a close relationship with actuarial credibility theory. While readily available programs such as the GLIMMIX procedure in SAS and the lme4 package in R are powerful tools for using this class of models, these progarms are not able to handle models with thousands of levels of fixed and random effects. By using sparse-matrix and other high performance techniques, procedures such as HPMIXED in SAS can easily fit models with thousands of factor levels, but only for normally distributed response variables. In this paper, we present the %HPGLIMMIX SAS macro that fits GLMMs with large number of sparsely populated design matrices using the doubly-iterative linearization (pseudo-likelihood method, in which the sparse-matrix-based HPMIXED is used for the inner iterations with the pseudo-variable constructed from the inverse-link function and the chosen model. Although the macro does not have the full functionality of the GLIMMIX procedure, time and memory savings can be large with the new macro. In applications in which design matrices contain many zeros and there are hundreds or thousands of factor levels, models can be fitted without exhausting computer memory, and 90% or better reduction in running time can be observed. Examples with a Poisson, binomial, and gamma conditional distribution are presented to demonstrate the usage and efficiency of this macro.

  6. SAS 3 survey of the soft X-ray background

    Science.gov (United States)

    Marshall, F. J.; Clark, G. W.

    1984-01-01

    The results of a survey of the soft X-ray sky in the C band (0.10-0.28keV) are reported. The observations were carried out using two independent flow proportional counters on board the SAS 3 X-ray satellite which had a total angular resolution of 2.9 deg FWHM, and a total exposure of 2.2 x 10 to the 4th per sq cm s sr. It is found that C band counting rates were generally inversely correlated with the column density of the neutral hydrogen on all angular scales down to the lowest angular resolution of the detectors. In the region 90-180 deg l and 0-10 deg b, the relation between C-band rates and the column densities of neutral hydrogen was fitted with a residual rms deviation of less than 13 percent by a two-component numerical model of the X-ray background. For the apparent attenuation column density a value of 2.7 x 10 to the 20th per sq cm was obtained. On the basis of a computer simulation of the SAS 3 data, it is shown that the observed clumping of interstellar matter was consistent with the magnitude of spatial fluctuations in the C-band map. When the background rates were subtracted from the survey map, the subsequent map showed foreground emission and absorption features with improved sensitivity and clarity. A series of computer-generated maps incorporating the SAS 3 data is given in an appendix.

  7. Categorical Data Analysis With Sas and Spss Applications

    CERN Document Server

    Lawal, H Bayo

    2003-01-01

    This book covers the fundamental aspects of categorical data analysis with an emphasis on how to implement the models used in the book using SAS and SPSS. This is accomplished through the frequent use of examples, with relevant codes and instructions, that are closely related to the problems in the text. Concepts are explained in detail so that students can reproduce similar results on their own. Beginning with chapter two, exercises at the end of each chapter further strengthen students' understanding of the concepts by requiring them to apply some of the ideas expressed in the text in a more

  8. Identify S.A.S. -Plan de empresa

    OpenAIRE

    2012-01-01

    IDENTIFY S.A.S. – Soluciones en Tecnología, tiene como objetivos desarrollar un plan de empresa para suplir una de las necesidades, que en la actualidad cobra importancia en los centros hospitalarios y que contribuye al control y detección automática de personas y activos y control de temperatura enn activos dedicados al almacenamiento de medicamentos e insumos, permitiendo el manejo de la información en tiempo real; teniendo presente la normatividad que las rige, la seguridad que les propor...

  9. Plan de empresa SZ Gastroconsulting S.A.S.

    OpenAIRE

    Zuloaga Galofre, David; Serrano Zuleta, Juanita

    2015-01-01

    SZ GastroConsulting S.A.S. es una empresa colombiana que prestará servicios de consultoría al sector de restaurantes. El core del negocio estará orientado a incrementar la rotación de clientes y la facturación de los restaurantes. De forma complementaria, se adoptarán prácticas tecnológicas, aprovechando el entorno actual donde los comensales inician su experiencia de consumo antes de ir al restaurante, y la finalizan días después de vivirla. La compañía será dirigida por los socios y consult...

  10. Plan de Negocios Qualitas S.A.S.

    OpenAIRE

    Verutti Bonilla, María Cecilia; Ávila González, Gloria Inés; Ortiz Alvarado, Francisco Javier

    2012-01-01

    Qualitas S.A.S. Health & Consulting (del latín: “calidad”), nace un equipo multidisciplinario de profesionales de crear una empresa de consultoría especializada en salud en Popayán, como apoyo a los Prestadores de Servicios de Salud, en aspectos relacionados con los requisitos que deben cumplir ante las normas del Sistema Obligatorio de Garantía de la Calidad en Salud que reglamentan la atención de calidad en los servicios de salud en Colombia, teniendo como meta la excelencia. Objetivos: R...

  11. Polymer encapsulation of amoxicillin microparticles by SAS process.

    Science.gov (United States)

    Montes, A; Baldauf, E; Gordillo, M D; Pereyra, C M; Martínez de la Ossa, E J

    2014-01-01

    Encapsulation of amoxicillin (AMC) with ethyl cellulose (EC) by a supercritical antisolvent process (SAS) was investigated. AMC microparticles obtained previously by an SAS process were used as host particles and EC, a biodegradable polymer used for the controlled release of drugs, was chosen as the coating material. In this work, a suspension of AMC microparticles in a solution of ethyl cellulose in dichloromethane (DCM) was sprayed through a nozzle into supercritical CO2. Scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) and HPLC analyses were carried out. The effects of AMC:EC ratio, the initial polymer concentration of the solution, temperature and pressure on the encapsulation process were investigated. Although all the experiments led to powder precipitation, the AMC encapsulation was achieved in only half of the cases, particularly when the lower drug:polymer ratios were assayed. In general, it was observed that the percentages of AMC present in the precipitates were higher on increasing the AMC:EC ratio. In these cases composites rather than encapsulates were obtained. The in vitro release profiles of the resulting materials were evaluated in order to ascertain whether composites can be used as encapsulated systems for drug delivery systems.

  12. Recent high energy gamma-ray results from SAS-2

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.; Bignami, G. F.; Ogelman, H. B.; Ozel, M. E.; Tumer, T.; Lamb, R. C.

    1977-01-01

    Recent developments in gamma-ray astronomy due to the results from SAS-2 have focused on two areas. First, the emission from the plane of the Galaxy is the dominant feature in the gamma-ray sky. The galactic latitude and longitude distributions are consistent with the concept that the high-energy radiation originates from cosmic rays interacting with interstellar matter, and the measurements support a galactic origin for cosmic rays. Second, searches of the SAS-2 data for emission from localized sources have shown three strong discrete gamma-ray sources: the Crab nebula and PSR 0531 + 21, the Vela supernova remnant and PSR 0833-45, and a source near galactic coordinates 193 deg longitude, +3 deg latitude, which does not appear to be associated with other known celestial objects. Evidence has also been found for pulsed gamma-ray emission from two other radio pulsars, PSR 1818-04 and PSR 1747-46. A localized source near longitudes 76-80 deg may be associated with the X-ray source Cyg X-3.

  13. The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation.

    Science.gov (United States)

    Rogala, Kacper B; Dynes, Nicola J; Hatzopoulos, Georgios N; Yan, Jun; Pong, Sheng Kai; Robinson, Carol V; Deane, Charlotte M; Gönczy, Pierre; Vakonakis, Ioannis

    2015-05-29

    Centrioles are microtubule-based organelles crucial for cell division, sensing and motility. In Caenorhabditis elegans, the onset of centriole formation requires notably the proteins SAS-5 and SAS-6, which have functional equivalents across eukaryotic evolution. Whereas the molecular architecture of SAS-6 and its role in initiating centriole formation are well understood, the mechanisms by which SAS-5 and its relatives function is unclear. Here, we combine biophysical and structural analysis to uncover the architecture of SAS-5 and examine its functional implications in vivo. Our work reveals that two distinct self-associating domains are necessary to form higher-order oligomers of SAS-5: a trimeric coiled coil and a novel globular dimeric Implico domain. Disruption of either domain leads to centriole duplication failure in worm embryos, indicating that large SAS-5 assemblies are necessary for function in vivo.

  14. pROC: an open-source package for R and S+ to analyze and compare ROC curves

    Directory of Open Access Journals (Sweden)

    Lisacek Frédérique

    2011-03-01

    Full Text Available Abstract Background Receiver operating characteristic (ROC curves are useful tools to evaluate classifiers in biomedical and bioinformatics applications. However, conclusions are often reached through inconsistent use or insufficient statistical analysis. To support researchers in their ROC curves analysis we developed pROC, a package for R and S+ that contains a set of tools displaying, analyzing, smoothing and comparing ROC curves in a user-friendly, object-oriented and flexible interface. Results With data previously imported into the R or S+ environment, the pROC package builds ROC curves and includes functions for computing confidence intervals, statistical tests for comparing total or partial area under the curve or the operating points of different classifiers, and methods for smoothing ROC curves. Intermediary and final results are visualised in user-friendly interfaces. A case study based on published clinical and biomarker data shows how to perform a typical ROC analysis with pROC. Conclusions pROC is a package for R and S+ specifically dedicated to ROC analysis. It proposes multiple statistical tests to compare ROC curves, and in particular partial areas under the curve, allowing proper ROC interpretation. pROC is available in two versions: in the R programming language or with a graphical user interface in the S+ statistical software. It is accessible at http://expasy.org/tools/pROC/ under the GNU General Public License. It is also distributed through the CRAN and CSAN public repositories, facilitating its installation.

  15. Micro-Nano : des comportements différents, des procédés à adapter

    OpenAIRE

    Guillemin, Jean-Philippe; Lamy, Peggy; Thomas, Gérard; Bonnefoy, Olivier

    2005-01-01

    6 pages; L'arrivée de nanomatériaux parmi les différents matériaux utilisés en pyrotechnie pose de nombreux problèmes de mise en œuvre. En effet, leurs propriétés texturales particulières ne permettent pas de les utiliser comme des matériaux classiques. Il est impératif d'adapter les procédés de mise en œuvre habituels. Pour obtenir l'adéquation de ces nouveaux matériaux et de nos procédés, des études spécifiques du comportement des nanomatériaux au cours des procédés de mise en œuvre par cou...

  16. SPSS and SAS programs for generalizability theory analyses.

    Science.gov (United States)

    Mushquash, Christopher; O'Connor, Brian P

    2006-08-01

    The identification and reduction of measurement errors is a major challenge in psychological testing. Most investigators rely solely on classical test theory for assessing reliability, whereas most experts have long recommended using generalizability theory instead. One reason for the common neglect of generalizability theory is the absence of analytic facilities for this purpose in popular statistical software packages. This article provides a brief introduction to generalizability theory, describes easy to use SPSS, SAS, and MATLAB programs for conducting the recommended analyses, and provides an illustrative example, using data (N = 329) for the Rosenberg Self-Esteem Scale. Program output includes variance components, relative and absolute errors and generalizability coefficients, coefficients for D studies, and graphs of D study results.

  17. Modeling binary correlated responses using SAS, SPSS and R

    CERN Document Server

    Wilson, Jeffrey R

    2015-01-01

    Statistical tools to analyze correlated binary data are spread out in the existing literature. This book makes these tools accessible to practitioners in a single volume. Chapters cover recently developed statistical tools and statistical packages that are tailored to analyzing correlated binary data. The authors showcase both traditional and new methods for application to health-related research. Data and computer programs will be publicly available in order for readers to replicate model development, but learning a new statistical language is not necessary with this book. The inclusion of code for R, SAS, and SPSS allows for easy implementation by readers. For readers interested in learning more about the languages, though, there are short tutorials in the appendix. Accompanying data sets are available for download through the book s website. Data analysis presented in each chapter will provide step-by-step instructions so these new methods can be readily applied to projects.  Researchers and graduate stu...

  18. Non-linear Growth Models in Mplus and SAS.

    Science.gov (United States)

    Grimm, Kevin J; Ram, Nilam

    2009-10-01

    Non-linear growth curves or growth curves that follow a specified non-linear function in time enable researchers to model complex developmental patterns with parameters that are easily interpretable. In this paper we describe how a variety of sigmoid curves can be fit using the Mplus structural modeling program and the non-linear mixed-effects modeling procedure NLMIXED in SAS. Using longitudinal achievement data collected as part of a study examining the effects of preschool instruction on academic gain we illustrate the procedures for fitting growth models of logistic, Gompertz, and Richards functions. Brief notes regarding the practical benefits, limitations, and choices faced in the fitting and estimation of such models are included.

  19. %ERA: A SAS Macro for Extended Redundancy Analysis

    Directory of Open Access Journals (Sweden)

    Pietro Giorgio Lovaglio

    2016-10-01

    Full Text Available A new approach to structural equation modeling based on so-called extended redundancy analysis has been recently proposed in the literature, enhanced with the added characteristic of generalizing redundancy analysis and reduced-rank regression models for more than two blocks. In this approach, the relationships between the observed exogenous variables and the observed endogenous variables are moderated by the presence of unobservable composites that were estimated as linear combinations of exogenous variables, permitting a great flexibility to specify and fit a variety of structural relationships. In this paper, we propose the SAS macro %ERA to specify and fit structural relationships in the extended redundancy analysis (ERA framework. Two examples (simulation and real data are provided in order to reproduce results appearing in the original article where ERA was proposed.

  20. SAS-2 galactic gamma ray results. 2. Localized sources

    Science.gov (United States)

    Hartman, R. C.; Fichtel, C. E.; Kniffen, D. A.; Lamb, R. C.; Thompson, D. J.; Bignami, G. F.; Oegelman, H.; Oezel, M. E.; Tuemer, T.

    1976-01-01

    Gamma-ray emission was detected from the radio pulsars PSR1818-04 and PSR1747-46, in addition to the previously reported gamma-ray emission from the Crab and Vela pulsars. Since the Crab pulsar is the only one observed in the optical and X-ray bands, these gamma-ray observations suggest a uniquely gamma-ray phenomenon occurring in a fraction of the radio pulsars. Using distance estimates it is found that PSR1818-04 has a gamma-ray luminosity comparable to that of the Crab pulsar, while the luminosities of PSR1747-46 and the Vela pulsar are approximately an order of magnitude lower. This survey of SAS-2 data for pulsar correlations has also yielded upper limits to gamma-ray luminosity for 71 other radio pulsars.

  1. Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth.

    Science.gov (United States)

    Sharma, Ashwani; Aher, Amol; Dynes, Nicola J; Frey, Daniel; Katrukha, Eugene A; Jaussi, Rolf; Grigoriev, Ilya; Croisier, Marie; Kammerer, Richard A; Akhmanova, Anna; Gönczy, Pierre; Steinmetz, Michel O

    2016-05-23

    Centrioles are fundamental and evolutionarily conserved microtubule-based organelles whose assembly is characterized by microtubule growth rates that are orders of magnitude slower than those of cytoplasmic microtubules. Several centriolar proteins can interact with tubulin or microtubules, but how they ensure the exceptionally slow growth of centriolar microtubules has remained mysterious. Here, we bring together crystallographic, biophysical, and reconstitution assays to demonstrate that the human centriolar protein CPAP (SAS-4 in worms and flies) binds and "caps" microtubule plus ends by associating with a site of β-tubulin engaged in longitudinal tubulin-tubulin interactions. Strikingly, we uncover that CPAP activity dampens microtubule growth and stabilizes microtubules by inhibiting catastrophes and promoting rescues. We further establish that the capping function of CPAP is important to limit growth of centriolar microtubules in cells. Our results suggest that CPAP acts as a molecular lid that ensures slow assembly of centriolar microtubules and, thereby, contributes to organelle length control.

  2. SAS program for quantitative stratigraphic correlation by principal components

    Science.gov (United States)

    Hohn, M.E.

    1985-01-01

    A SAS program is presented which constructs a composite section of stratigraphic events through principal components analysis. The variables in the analysis are stratigraphic sections and the observational units are range limits of taxa. The program standardizes data in each section, extracts eigenvectors, estimates missing range limits, and computes the composite section from scores of events on the first principal component. Provided is an option of several types of diagnostic plots; these help one to determine conservative range limits or unrealistic estimates of missing values. Inspection of the graphs and eigenvalues allow one to evaluate goodness of fit between the composite and measured data. The program is extended easily to the creation of a rank-order composite. ?? 1985.

  3. Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos.

    Science.gov (United States)

    Kitagawa, Daiju; Busso, Coralie; Flückiger, Isabelle; Gönczy, Pierre

    2009-12-01

    Despite being essential for proper cell division, the mechanisms governing centrosome duplication are incompletely understood and represent an important open question in cell biology. Formation of a new centriole next to each existing one is critical for centrosome duplication. In Caenorhabditis elegans embryos, the proteins SPD-2, ZYG-1, SAS-6, SAS-5, and SAS-4 are essential for centriole formation, but the mechanisms underlying their requirement remain unclear. Here, we demonstrate that the kinase ZYG-1 phosphorylates the coiled-coil protein SAS-6 at serine 123 in vitro. Importantly, we show that this phosphorylation event is crucial for centriole formation in vivo. Furthermore, we establish that such phosphorylation ensures the maintenance of SAS-6 at the emerging centriole. Overall, our findings establish that phosphorylation of the evolutionarily conserved protein SAS-6 is critical for centriole formation and thus for faithful cell division.

  4. LSI推出首批半高SAS RAID适配器

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    LSI Logic公司近日宣布推出首批半高(low—profile,LP)SAS RAID存储适配器。新的MegaRAID SAS 8308ELP和SAS8344ELP是具有8个SAS端口的PCI Express接口适配器,应用于需要使用3GbpsSAS和/或SATAⅡ驱动器的服务器和工作站环境。

  5. Find the fish: using PROC SQL to build a relational database

    Science.gov (United States)

    Fabrizio, Mary C.; Nelson, Scott N.

    1995-01-01

    Reliable estimates of abundance and survival, gained through mark-recapture studies, are necessary to better understand how to manage and restore lake trout populations in the Great Lakes. Working with a 24-year data set from a mark-recapture study conducted in Lake Superior, we attempted to disclose information on tag shedding by examining recaptures of double-tagged fish. The data set consisted of 64,288 observations on fish which had been marked with one or more tags; a subset of these fish had been marked with two tags at initial capture. Although DATA and PROC statements could be used to obtain some of the information we sought, these statements could not be used to extract a complete set of results from the double-tagging experiments. We therefore used SQL processing to create three tables representing the same information but in a fully normalized relational structure. In addition, we created indices to efficiently examine complex relationships among the individual capture records. This approach allowed us to obtain all the information necessary to estimate tag retention through subsequent modeling. We believe that our success with SQL was due in large part to its ability to simultaneosly scan the same table more than once and to permit consideration of other tables in sub-queries.

  6. Le procédé du collage dans l’oeuvre de Max Ernst

    Directory of Open Access Journals (Sweden)

    Márcia Maria Valle Arbex

    2011-10-01

    Full Text Available Considerado um dos inventores da colagem, no sentido moderno da palavra, Max Ernst desenvolve a técnica estendendo sua prática e transformando-a em conceito. Nossa reflexão aborda este “recurso” sob ângulo de sua relação com a noção de imagem surrealista, a partir de exemplos de trabalhos executados em 1919-1920, onde as imagens vêm acompanhadas de legendas, formando o que chamamos de poema-duplo.Considéré l’un des créateurs du collage dans le sens moderne du mot, Max Ernst développe cete technique en élargissant sa pratique et en la transformant en concept. Notre réflexion porte sur ce “procédé”, sous l’angle de ses rapports avec la notion d’image poétique surréaliste, à partir d’exemples de travaux réalisés en 1919-1920, où des légendes accompagnent les images formant une sorte poème-double.

  7. Validity of Simpson-Angus Scale (SAS in a naturalistic schizophrenia population

    Directory of Open Access Journals (Sweden)

    Tuisku Katinka

    2005-03-01

    Full Text Available Abstract Background Simpson-Angus Scale (SAS is an established instrument for neuroleptic-induced parkinsonism (NIP, but its statistical properties have been studied insufficiently. Some shortcomings concerning its content have been suggested as well. According to a recent report, the widely used SAS mean score cut-off value 0.3 of for NIP detection may be too low. Our aim was to evaluate SAS against DSM-IV diagnostic criteria for NIP and objective motor assessment (actometry. Methods Ninety-nine chronic institutionalised schizophrenia patients were evaluated during the same interview by standardised actometric recording and SAS. The diagnosis of NIP was based on DSM-IV criteria. Internal consistency measured by Cronbach's α, convergence to actometry and the capacity for NIP case detection were assessed. Results Cronbach's α for the scale was 0.79. SAS discriminated between DSM-IV NIP and non-NIP patients. The actometric findings did not correlate with SAS. ROC-analysis yielded a good case detection power for SAS mean score. The optimal threshold value of SAS mean score was between 0.65 and 0.95, i.e. clearly higher than previously suggested threshold value. Conclusion We conclude that SAS seems a reliable and valid instrument. The previously commonly used cut-off mean score of 0.3 has been too low resulting in low specificity, and we suggest a new cut-off value of 0.65, whereby specificity could be doubled without loosing sensitivity.

  8. 关于SAS-Weblogic的数据挖掘模型的应用分析

    Institute of Scientific and Technical Information of China (English)

    周清松

    2015-01-01

    本文在对SAS-Weblogic的数据挖掘模型和应用进行应用分析时,首先分析了SAS-Weblogic的数据挖掘模型,最后基于实例分析了SAS-Weblogic的数据挖掘模型的具体应用。SAS-Weblogic数据挖掘模型不仅仅解决了一般数据量的设计要求,结合ARIMA模型同样对于大数据量的设计要求也能得到有效的解决。

  9. Observations of low energy gamma-ray bursts with SAS-2

    Science.gov (United States)

    Oegelman, H.; Fichtel, C. E.; Kniffen, D. A.

    1975-01-01

    The present paper reports on the low-energy gamma-ray bursts observed by the plastic scintillator anticoincidence dome of the Small Astronomy Satellite-2 (SAS-2) gamma-ray telescope. SAS-2 detected two events observed by other satellites and discovered one which was subsequently confirmed by other satellite observations. Two events seen by other satellites were not detected by SAS-2, probably due to earth occultation. The event detection threshold for SAS-2 was almost two orders of magnitude lower than that of the Vela satellites.

  10. A SAS/IML program using the Kalman filter for estimating state space models.

    Science.gov (United States)

    Gu, Fei; Yung, Yiu-Fai

    2013-03-01

    To help disseminate the knowledge and software implementation of a state space model (SSM), this article provides a SAS/IML (SAS Institute, 2010) program for estimating the parameters of general linear Gaussian SSMs using the Kalman filter algorithm. In order to use this program, the user should have SAS installed on a computer and have a valid license for SAS/IML. Since the code is completely open, it is expected that this program can be used not only by applied researchers, but also by quantitative methodologists who are interested in improving their methods and promoting SSM as a research instrument.

  11. PP2A phosphatase acts upon SAS-5 to ensure centriole formation in C. elegans embryos.

    Science.gov (United States)

    Kitagawa, Daiju; Flückiger, Isabelle; Polanowska, Jolanta; Keller, Debora; Reboul, Jérôme; Gönczy, Pierre

    2011-04-19

    Centrosome duplication occurs once per cell cycle and ensures that the two resulting centrosomes assemble a bipolar mitotic spindle. Centriole formation is fundamental for centrosome duplication. In Caenorhabditis elegans, the evolutionarily conserved proteins SPD-2, ZYG-1, SAS-6, SAS-5, and SAS-4 are essential for centriole formation, but how they function is not fully understood. Here, we demonstrate that Protein Phosphatase 2A (PP2A) is also critical for centriole formation in C. elegans embryos. We find that PP2A subunits genetically and physically interact with the SAS-5/SAS-6 complex. Furthermore, we show that PP2A-mediated dephosphorylation promotes centriolar targeting of SAS-5 and ensures SAS-6 delivery to the site of centriole assembly. We find that PP2A is similarly needed for the presence of HsSAS-6 at centrioles and for centriole formation in human cells. These findings lead us to propose that PP2A-mediated loading of SAS-6 proteins is critical at the onset of centriole formation.

  12. SAS molecular tests Salmonella detection kit. Performance tested method 021202.

    Science.gov (United States)

    Bapanpally, Chandra; Montier, Laura; Khan, Shah; Kasra, Akif; Brunelle, Sharon L

    2014-01-01

    The SAS Molecular tests Salmonella Detection method, a Loop-mediated Isothermal Amplification method, performed as well as or better than the U.S. Department of Agriculture-Food Safety Inspection Service Microbiology Laboratory Guidebook and the U.S. Food and Drug Administration Bacteriological Analytical Manual reference methods for ground beef, beef trim, ground turkey, chicken carcass rinses, bagged mixed lettuce, and fresh spinach. The ground beef (30% fat, 25 g test portion), poultry matrixes and leafy greens were validated in a 6-7 h enrichment, and ground beef (30% fat, 375 g composite test portion) and beef trim (375 g composite test portion) were validated in a 16-20 h enrichment. The method performance for meat and leafy green matrixes was shown to be acceptable under conditions of co-enrichment with Escherichia coli 0157. Thus, after a short 6-7 h co-enrichment step, ground beef, beef trim, lettuce, and spinach can be tested for both Salmonella and E. coli O157. Inclusivity and exclusivity testing revealed no false negatives and no false positives among the 100 Salmonella serovars and 30 non-Salmonella species examined. The method was shown to be robust when enrichment time, DNA extract hold time, and DNA volume were varied.

  13. Circinus X-1 - X-ray observations with SAS 3

    Science.gov (United States)

    Dower, R. G.; Bradt, H. V.; Morgan, E. H.

    1982-01-01

    Eight observations of Cir X-1 with SAS 3, each lasting 1-6 days, have yielded a variety of new phenomena, viz., a luminous state of steady emission, rapid large-intensity dips, an extremely rapid X-ray transition, and bright flares. Through searches for periodic X-ray pulsations were carried out on data trains of duration up to 6 days; upper limits for pulsations with periods greater than 250 microsec range down to 0.3%. Aperiodic variability with characteristic times of 0.4-1.0 sec was observed but is not well characterized by a simple shot noise model. No millisecond bursts were observed during 40,000 sec in three separate observations. Spectral parameters derived before and after several X-ray transitions indicate that the transitions are not due to absorption of X-rays by intervening gas. Models previously proposed for the Cir X-1 system do not easily provide explanations for all the complex phenomena reported herein.

  14. SAS-2 galactic gamma-ray results. 2: Localized sources

    Science.gov (United States)

    Hartman, R. C.; Fichtel, C. E.; Kniffen, D. A.; Lamb, R. C.; Thompson, D. J.; Bignami, G. F.; Oegelman, H.; Oezel, M. E.; Tuemer, T.

    1977-01-01

    Gamma ray emission was detected from the radio pulsars PSR 1818-04 and PSR 1747-46, in addition to the previously reported gamma ray emission from the Crab and Vela pulsars. Because the Crab pulsar is the only one observed in the optical and X-ray bands, these gamma ray observations suggest a uniquely gamma ray phenomenon occurring in a fraction of the radio pulsars. PSR 1818-04 has a gamma ray luminosity comparable to that of the Crab pulsar, whereas the luminosities of PSR 1747-46 and the Vela pulsar are approximately an order of magnitude lower. SAS-2 data for pulsar correlations yielded upper limits to gamma ray luminosity for 71 other radio pulsars. For five of the closest pulsars, upper limits for gamma ray luminosity are found to be at least three orders of magnitude lower than that of the Crab pulsar. Gamma ray enhancement near the Milky Way satellite galaxy and the galactic plane in the Cygnus region is also discussed.

  15. Using SAS/IntrNet for Evaluating Web-Based Courses.

    Science.gov (United States)

    Yu, Chong-ho; Jannasch-Pennell, Angel; Digangi, Sam; Wasson, Barnaby

    1998-01-01

    Describes the use of SAS/IntrNet, a Web service rather than a Web server, to evaluate and enhance university level Web-based courses. IntrNet provides the ability to create both static and dynamic Web pages, using Web publishing tools to convert SAS output to hypertext markup language for the creation of static Web pages. (Author/LRW)

  16. Using SAS/IntrNet for Evaluating Web-Based Courses.

    Science.gov (United States)

    Yu, Chong-ho; Jannasch-Pennell, Angel; Digangi, Sam; Wasson, Barnaby

    1998-01-01

    Describes the use of SAS/IntrNet, a Web service rather than a Web server, to evaluate and enhance university level Web-based courses. IntrNet provides the ability to create both static and dynamic Web pages, using Web publishing tools to convert SAS output to hypertext markup language for the creation of static Web pages. (Author/LRW)

  17. SAS üritab panna riiki lennufirma aktsiaid müüma / Lemmi Kann

    Index Scriptorium Estoniae

    Kann, Lemmi

    2007-01-01

    SAS-i eesmärgiks on saada enamusosalus nii Estonian Airis kui ka airBalticus, et seeläbi oma positsioone Baltimaades kinnistada. Diagramm: Estonian Airi majandusnäitajad ja omanikud. Vt. samas: SAS on Estonian Airi jahtinud kaua. Kommenteerib Raivo Vare

  18. SAS tahab Estonian Airi liita lätlaste firmaga airBaltic / Andres Eilart

    Index Scriptorium Estoniae

    Eilart, Andres

    2007-01-01

    SAS plaanib Estonian Airi ja Läti firma airBalticu liitmisega luua uue lennufirma. Autori hinnangul viitavad Estonian Airi laienemisplaanidele kriipsu peale tõmbamine ja SAS-i investeeringud airBalticusse sellele, et ühendamise käigus "neelab" Läti firma Estonian Airi

  19. Social Anxiety Scale for Adolescents (SAS-A): Measuring Social Anxiety among Finnish Adolescents

    Science.gov (United States)

    Ranta, Klaus; Junttila, Niina; Laakkonen, Eero; Uhmavaara, Anni; La Greca, Annette M.; Niemi, Paivi M.

    2012-01-01

    The aim of this study was to investigate symptoms of social anxiety and the psychometric properties of the "Social Anxiety Scale for Adolescents" (SAS-A) among Finnish adolescents, 13-16 years of age. Study 1 (n = 867) examined the distribution of SAS-A scores according to gender and age, and the internal consistency and factor structure…

  20. Pro-C5, a marker of true type V collagen formation and fibrillation, correlates with portal hypertension in patients with alcoholic cirrhosis

    DEFF Research Database (Denmark)

    Leeming, Diana J; Veidal, Sanne S; Karsdal, Morten A

    2015-01-01

    Pro-C5 reflects liver hemodynamics, liver function, disease stage and clinically significant portal hypertension (PH). A multimarker model in combination with clinical scores predicted HVPG and separated clinical relevant HVPG thresholds. Plasma Pro-C5 may be suitable for the noninvasive evaluation...

  1. [Standardization of the Greek version of Zung's Self-rating Anxiety Scale (SAS)].

    Science.gov (United States)

    Samakouri, M; Bouhos, G; Kadoglou, M; Giantzelidou, A; Tsolaki, K; Livaditis, M

    2012-01-01

    Self-rating Anxiety Scale (SAS), introduced by Zung, has been widely used in research and in clinical practice for the detection of anxiety. The present study aims at standardizing the Greek version of SAS. SAS consists of 20 items rated on a 1-4 likert type scale. The total SAS score may vary from 20 (no anxiety at all) to 80 (severe anxiety). Two hundred and fifty four participants (114 male and 140 female), psychiatric patients, physically ill and general population individuals, aged 45.40±11.35 years, completed the following: (a) a demographic characteristics' questionnaire, (b) the SAS Greek version, (c) the Spielberg's Modified Greek State-Trait Anxiety Scale (STAI-Gr.-X) and (d) the Zung Depression Rating Scale (ZDRS). Seventy six participants answered the SAS twice within a 12th-day median period of time. The following parameters were calculated: (a) internal consistency of the SAS in terms of Cronbach's α co-efficient, (b) its test-retest reliability in terms of the Intraclass Correlation Coefficient (ICC) and (c) its concurrent and convergent validities through its score's Spearman's rho correlations with both the state and trait subscales of STAI-Gr X and the ZDRS. In addition, in order to evaluate SAS' discriminant validity, the scale's scores of the three groups of participants (psychiatric patients, physically ill and general population individuals) were compared among each other, in terms of Kruskall Wallis and Mann Whitney U tests. SAS Cronbach's alpha equals 0.897 while ICC regarding its test-retest reliability equals 0.913. Spearman's rho concerning validity: (a) when SAS is compared to STAI-Gr.-X (state), equals it 0.767, (b) when SAS is compared to STAI-Gr. X (trait), it equals 0.802 and (c) when SAS is compared to ZDRS, it equals 0.835. The mentally ill scored significantly higher in SAS compared to both the healthy and the general population. In conclusion, the SAS Greek version presents very satisfactory psychometric properties regarding

  2. SAS-1 is a C2 domain protein critical for centriole integrity in C. elegans.

    Science.gov (United States)

    von Tobel, Lukas; Mikeladze-Dvali, Tamara; Delattre, Marie; Balestra, Fernando R; Blanchoud, Simon; Finger, Susanne; Knott, Graham; Müller-Reichert, Thomas; Gönczy, Pierre

    2014-11-01

    Centrioles are microtubule-based organelles important for the formation of cilia, flagella and centrosomes. Despite progress in understanding the underlying assembly mechanisms, how centriole integrity is ensured is incompletely understood, including in sperm cells, where such integrity is particularly critical. We identified C. elegans sas-1 in a genetic screen as a locus required for bipolar spindle assembly in the early embryo. Our analysis reveals that sperm-derived sas-1 mutant centrioles lose their integrity shortly after fertilization, and that a related defect occurs when maternal sas-1 function is lacking. We establish that sas-1 encodes a C2 domain containing protein that localizes to centrioles in C. elegans, and which can bind and stabilize microtubules when expressed in human cells. Moreover, we uncover that SAS-1 is related to C2CD3, a protein required for complete centriole formation in human cells and affected in a type of oral-facial-digital (OFD) syndrome.

  3. SAS-1 is a C2 domain protein critical for centriole integrity in C. elegans.

    Directory of Open Access Journals (Sweden)

    Lukas von Tobel

    2014-11-01

    Full Text Available Centrioles are microtubule-based organelles important for the formation of cilia, flagella and centrosomes. Despite progress in understanding the underlying assembly mechanisms, how centriole integrity is ensured is incompletely understood, including in sperm cells, where such integrity is particularly critical. We identified C. elegans sas-1 in a genetic screen as a locus required for bipolar spindle assembly in the early embryo. Our analysis reveals that sperm-derived sas-1 mutant centrioles lose their integrity shortly after fertilization, and that a related defect occurs when maternal sas-1 function is lacking. We establish that sas-1 encodes a C2 domain containing protein that localizes to centrioles in C. elegans, and which can bind and stabilize microtubules when expressed in human cells. Moreover, we uncover that SAS-1 is related to C2CD3, a protein required for complete centriole formation in human cells and affected in a type of oral-facial-digital (OFD syndrome.

  4. First report of sasX-positive methicillin-resistant Staphylococcus aureus in Japan.

    Science.gov (United States)

    Nakaminami, Hidemasa; Ito, Teruyo; Han, Xiao; Ito, Ayumu; Matsuo, Miki; Uehara, Yuki; Baba, Tadashi; Hiramatsu, Keiichi; Noguchi, Norihisa

    2017-09-01

    SasX is a known virulence factor of Staphylococcus aureus involved in colonisation and immune evasion of the bacterium. The sasX gene, which is located on the ϕSPβ prophage, is frequently found in the sequence type (ST) 239 S. aureus lineage, which is the predominant healthcare-associated clone in Asian countries. In Japan, ST239 clones have rarely been identified, and sasX-positive strains have not been reported to date. Here, we report the first identification of 18 sasX-positive methicillin-resistant S. aureus (MRSA) strains in Japanese hospitals between 2009 and 2011. All sasX-positive isolates belonged to an ST239-staphylococcal cassette chromosome mec type III (ST239-III) lineage. However, we were unable to identify additional sasX-positive MRSA strains from 2012 to 2016, indicating that the small epidemic of sasX-positive isolates observed in this study was temporary. The sequence surrounding sasX in the strain TOHH628 lacked 51 genes that encode phage packaging and structural proteins, and no bacteriophage was induced by mitomycin C. Additionally, in the TOHH628 strain, the region (64.6 kb) containing sasX showed high identity to the ϕSPβ-like element (71.3 kb) of the Taiwanese MRSA strain Z172. The data strongly suggest that the present sasX-positive isolates found in Japanese hospitals were transmitted incidentally from other countries. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  5. Zinc-dependent mechanical properties of Staphylococcus aureus biofilm-forming surface protein SasG.

    Science.gov (United States)

    Formosa-Dague, Cécile; Speziale, Pietro; Foster, Timothy J; Geoghegan, Joan A; Dufrêne, Yves F

    2016-01-12

    Staphylococcus aureus surface protein SasG promotes cell-cell adhesion during the accumulation phase of biofilm formation, but the molecular basis of this interaction remains poorly understood. Here, we unravel the mechanical properties of SasG on the surface of living bacteria, that is, in its native cellular environment. Nanoscale multiparametric imaging of living bacteria reveals that Zn(2+) strongly increases cell wall rigidity and activates the adhesive function of SasG. Single-cell force measurements show that SasG mediates cell-cell adhesion via specific Zn(2+)-dependent homophilic bonds between β-sheet-rich G5-E domains on neighboring cells. The force required to unfold individual domains is remarkably strong, up to ∼500 pN, thus explaining how SasG can withstand physiological shear forces. We also observe that SasG forms homophilic bonds with the structurally related accumulation-associated protein of Staphylococcus epidermidis, suggesting the possibility of multispecies biofilms during host colonization and infection. Collectively, our findings support a model in which zinc plays a dual role in activating cell-cell adhesion: adsorption of zinc ions to the bacterial cell surface increases cell wall cohesion and favors the projection of elongated SasG proteins away from the cell surface, thereby enabling zinc-dependent homophilic bonds between opposing cells. This work demonstrates an unexpected relationship between mechanics and adhesion in a staphylococcal surface protein, which may represent a general mechanism among bacterial pathogens for activating cell association.

  6. SAS-6 assembly templated by the lumen of cartwheel-less centrioles precedes centriole duplication.

    Science.gov (United States)

    Fong, Chii Shyang; Kim, Minhee; Yang, T Tony; Liao, Jung-Chi; Tsou, Meng-Fu Bryan

    2014-07-28

    Centrioles are 9-fold symmetric structures duplicating once per cell cycle. Duplication involves self-oligomerization of the centriolar protein SAS-6, but how the 9-fold symmetry is invariantly established remains unclear. Here, we found that SAS-6 assembly can be shaped by preexisting (or mother) centrioles. During S phase, SAS-6 molecules are first recruited to the proximal lumen of the mother centriole, adopting a cartwheel-like organization through interactions with the luminal wall, rather than via their self-oligomerization activity. The removal or release of luminal SAS-6 requires Plk4 and the cartwheel protein STIL. Abolishing either the recruitment or the removal of luminal SAS-6 hinders SAS-6 (or centriole) assembly at the outside wall of mother centrioles. After duplication, the lumen of engaged mother centrioles becomes inaccessible to SAS-6, correlating with a block for reduplication. These results lead to a proposed model that centrioles may duplicate via a template-based process to preserve their geometry and copy number.

  7. Self-assembling SAS-6 multimer is a core centriole building block.

    Science.gov (United States)

    Gopalakrishnan, Jayachandran; Guichard, Paul; Smith, Andrew H; Schwarz, Heinz; Agard, David A; Marco, Sergio; Avidor-Reiss, Tomer

    2010-03-19

    Centrioles are conserved microtubule-based organelles with 9-fold symmetry that are essential for cilia and mitotic spindle formation. A conserved structure at the onset of centriole assembly is a "cartwheel" with 9-fold radial symmetry and a central tubule in its core. It remains unclear how the cartwheel is formed. The conserved centriole protein, SAS-6, is a cartwheel component that functions early in centriole formation. Here, combining biochemistry and electron microscopy, we characterize SAS-6 and show that it self-assembles into stable tetramers, which serve as building blocks for the central tubule. These results suggest that SAS-6 self-assembly may be an initial step in the formation of the cartwheel that provides the 9-fold symmetry. Electron microscopy of centrosomes identified 25-nm central tubules with repeating subunits and show that SAS-6 concentrates at the core of the cartwheel. Recombinant and native SAS-6 self-oligomerizes into tetramers with approximately 6-nm subunits, and these tetramers are components of the centrosome, suggesting that tetramers are the building blocks of the central tubule. This is further supported by the observation that elevated levels of SAS-6 in Drosophila cells resulted in higher order structures resembling central tubule morphology. Finally, in the presence of embryonic extract, SAS-6 tetramers assembled into high density complexes, providing a starting point for the eventual in vitro reconstruction of centrioles.

  8. [Generating person-years and calculating SMR using SAS: a simple program for exact calculations].

    Science.gov (United States)

    Marchand, J-L

    2010-10-01

    The computation of standardized incidence/mortality ratios or Poisson regression requires the calculation of person-years generated in a cohort. Softwares can do that, but SAS users still need to program this step themselves. Various algorithms were published previously, but they do not perform exact calculations: the present paper describes a simple program, which creates exact person-years, and computes SMRs. This program provides a referenced tool to perform this analysis in a cohort, with SAS or another language (the algorithm used can be easily adapted). Copyright © 2010 Elsevier Masson SAS. All rights reserved.

  9. SAS paneb Estonian Airi kiirmüüki / Gert D. Hankewitz

    Index Scriptorium Estoniae

    Hankewitz, Gert D.

    2009-01-01

    Majandusraskustes lennufirma SAS kavatseb loobuda osalustest kõigis lennufirmades, mis ei sobi kokku nende uue tegevuskavaga. Majandus- ja kommunikatsiooniminister Juhan Parts arvab, et riik peaks leidma Estonian Airile kodumaised partnerid

  10. Physicochemical properties and oral bioavailability of ursolic acid nanoparticles using supercritical anti-solvent (SAS) process.

    Science.gov (United States)

    Yang, Lei; Sun, Zhen; Zu, Yuangang; Zhao, Chunjian; Sun, Xiaowei; Zhang, Zhonghua; Zhang, Lin

    2012-05-01

    The objective of the study was to prepare ursolic acid (UA) nanoparticles using the supercritical anti-solvent (SAS) process and evaluate its physicochemical properties and oral bioavailability. The effects of four process variables, pressure, temperature, drug concentration and drug solution flow rate, on drug particle formation during SAS process, were investigated. Particles with mean particle size ranging from 139.2±19.7 to 1039.8±65.2nm were obtained by varying the process parameters. The UA was characterised by scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, thermal gravimetric analysis, specific surface area, dissolution test and bioavailability test. It was concluded that physicochemical properties and bioavailability of crystalline UA could be improved by physical modification, such as particle size reduction and generation of amorphous state using SAS process. Further, SAS process was a powerful methodology for improving the physicochemical properties and bioavailability of UA.

  11. SAS ihub hammast Estonian Airile / Lauri Linnamäe, Meeli Vilukas

    Index Scriptorium Estoniae

    Linnamäe, Lauri

    2007-01-01

    Skandinaavia lennukompanii SAS soovib suurendada osalust Estonian Airis ja Läti airBalticus, soovides luua Baltimaade tugevaima lennufirma. Peaminister Andrus Ansipi sõnul on Eesti kaalunud oma osaluse müüki Estonian Airis. Lisa: Omanikering

  12. Reactivity and fate of secondary alkane sulfonates (SAS) in marine sediments.

    Science.gov (United States)

    Baena-Nogueras, Rosa María; Rojas-Ojeda, Patricia; Sanz, José Luis; González-Mazo, Eduardo; Lara-Martín, Pablo A

    2014-06-01

    This research is focused on secondary alkane sulfonates (SAS), anionic surfactants widely used in household applications that access aquatic environments mainly via sewage discharges. We studied their sorption capacity and anaerobic degradation in marine sediments, providing the first data available on this topic. SAS partition coefficients increased towards those homologues having longer alkyl chains (from up to 141 L kg(-1) for C14 to up to 1753 L kg(-1) for C17), which were those less susceptible to undergo biodegradation. Overall, SAS removal percentages reached up to 98% after 166 days of incubation using anoxic sediments. The degradation pathway consisted on the formation of sulfocarboxylic acids after an initial fumarate attack of the alkyl chain and successive β-oxidations. This is the first study showing that SAS can be degraded in absence of oxygen, so this new information should be taken into account for future environmental risk assessments on these chemicals.

  13. SAS 2 observation of pulsed high-energy gamma radiation from Geminga

    Science.gov (United States)

    Mattox, J. R.; Bertsch, D. L.; Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.; Thompson, D. J.

    1992-01-01

    Following the detection of pulsed X-rays and gamma rays from Geminga, the 1972-1973 SAS 2 data which first revealed this source have been reanalyzed. The 237 ms periodicity is visible in those observations. The phase of the SAS 2 periodicity is consistent with that of COS B suggesting that the gamma-ray data allow an accounting for every revolution of the Geminga pulsar between 1972 and 1982.

  14. Comparative assessment of SAS and DES turbulence modeling for massively separated flows

    Science.gov (United States)

    Zheng, Weilin; Yan, Chao; Liu, Hongkang; Luo, Dahai

    2016-02-01

    Numerical studies of the flow past a circular cylinder at Reynolds number 1.4× 105 and NACA0021 airfoil at the angle of attack 60° have been carried out by scale-adaptive simulation (SAS) and detached eddy simulation (DES), in comparison with the existing experimental data. The new version of the model developed by Egorov and Menter is assessed, and advantages and disadvantages of the SAS simulation are analyzed in detail to provide guidance for industrial application in the future. Moreover, the mechanism of the scale-adaptive characteristics in separated regions is discussed, which is obscure in previous analyses. It is concluded that: the mean flow properties satisfactorily agree with the experimental results for the SAS simulation, although the prediction of the second order turbulent statistics in the near wake region is just reasonable. The SAS model can produce a larger magnitude of the turbulent kinetic energy in the recirculation bubble, and, consequently, a smaller recirculation region and a more rapid recovery of the mean velocity outside the recirculation region than the DES approach with the same grid resolution. The vortex shedding is slightly less irregular with the SAS model than with the DES approach, probably due to the higher dissipation of the SAS simulation under the condition of the coarse mesh.

  15. SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.

    Science.gov (United States)

    Hilbert, Manuel; Noga, Akira; Frey, Daniel; Hamel, Virginie; Guichard, Paul; Kraatz, Sebastian H W; Pfreundschuh, Moritz; Hosner, Sarah; Flückiger, Isabelle; Jaussi, Rolf; Wieser, Mara M; Thieltges, Katherine M; Deupi, Xavier; Müller, Daniel J; Kammerer, Richard A; Gönczy, Pierre; Hirono, Masafumi; Steinmetz, Michel O

    2016-04-01

    Centrioles are critical for the formation of centrosomes, cilia and flagella in eukaryotes. They are thought to assemble around a nine-fold symmetric cartwheel structure established by SAS-6 proteins. Here, we have engineered Chlamydomonas reinhardtii SAS-6-based oligomers with symmetries ranging from five- to ten-fold. Expression of a SAS-6 mutant that forms six-fold symmetric cartwheel structures in vitro resulted in cartwheels and centrioles with eight- or nine-fold symmetries in vivo. In combination with Bld10 mutants that weaken cartwheel-microtubule interactions, this SAS-6 mutant produced six- to eight-fold symmetric cartwheels. Concurrently, the microtubule wall maintained eight- and nine-fold symmetries. Expressing SAS-6 with analogous mutations in human cells resulted in nine-fold symmetric centrioles that exhibited impaired length and organization. Together, our data suggest that the self-assembly properties of SAS-6 instruct cartwheel symmetry, and lead us to propose a model in which the cartwheel and the microtubule wall assemble in an interdependent manner to establish the native architecture of centrioles.

  16. Preparation and pharmaceutical characterization of amorphous cefdinir using spray-drying and SAS-process.

    Science.gov (United States)

    Park, Junsung; Park, Hee Jun; Cho, Wonkyung; Cha, Kwang-Ho; Kang, Young-Shin; Hwang, Sung-Joo

    2010-08-30

    The aim of this study was to investigate the effects of micronization and amorphorization of cefdinir on solubility and dissolution rate. The amorphous samples were prepared by spray-drying (SD) and supercritical anti-solvent (SAS) process, respectively and their amorphous natures were confirmed by DSC, PXRD and FT-IR. Thermal gravimetric analysis was performed by TGA. SEM was used to investigate the morphology of particles and the processed particle had a spherical shape, while the unprocessed crystalline particle had a needle-like shape. The mean particle size and specific surface area were measured by dynamic light scattering (DLS) and BET, respectively. The DLS result showed that the SAS-processed particle was the smallest, followed by SD and the unprocessed cefdinir. The BET result was the same as DLS result in that the SAS-processed particle had the largest surface area. Therefore, the processed cefdinir, especially the SAS-processed particle, appeared to have enhanced apparent solubility, improved intrinsic dissolution rate and better drug release when compared with SD-processed and unprocessed crystalline cefdinir due not only to its amorphous nature, but also its reduced particle size. Conclusions were that the solubility and dissolution rate of crystalline cefdinir could be improved by physically modifying the particles using SD and SAS-process. Furthermore, SAS-process was a powerful methodology for improving the solubility and dissolution rate of cefdinir.

  17. Different Effects of Startling Acoustic Stimuli (SAS) on TMS-Induced Responses at Rest and during Sustained Voluntary Contraction.

    Science.gov (United States)

    Chen, Yen-Ting; Li, Shengai; Zhou, Ping; Li, Sheng

    2016-01-01

    Previous studies have shown that a habituated startling acoustic stimulus (SAS) can cause a transient suppression of motor evoked potentials (MEPs) induced by transcranial magnetic stimulation (TMS) during light muscle contraction. However, it is still unknown whether this phenomenon persists when at rest or during a sustained voluntary contraction task. Therefore, the purpose of this study was to determine whether a conditioning SAS has different effects. TMS was delivered to the hot spot for the left biceps on 11 subjects at rest both with and without a conditioning SAS. Of the 11subjects, 9 also had TMS delivered during isometric flexion of the left elbow, also with and without a conditioning SAS. TMS-induced MEPs, TMS-induced force, and silent periods were used to determine the effect of conditioning SAS. Consistent with previous findings, TMS-induced MEPs were smaller with a conditioning SAS (0.49 ± 0.37 mV) as compared without the SAS (0.69 ± 0.52 mV) at rest. However, a conditioning SAS during the voluntary contraction tasks resulted in a significant shortening of the MEP silent period (187.22 ± 22.99 ms with SAS vs. 200.56 ± 29.71 ms without SAS) without any changes in the amplitude of the MEP (1.37 ± 0.9 mV with SAS V.S. 1.32 ± 0.92 mV without SAS) or the TMS-induced force (3.11 ± 2.03 N-m with SAS V.S. 3.62 ± 1.33 N-m without SAS). Our results provide novel evidence that a conditioning SAS has different effects on the excitability of the motor cortex when at rest or during sustained voluntary contractions.

  18. Mesures de procédure spéciales et respect des droits de l'homme Rapport général

    NARCIS (Netherlands)

    Vervaele, J.A.E.

    2009-01-01

    Le but du rapport général est de mener une analyse comparative des rapports nationaux en vue de présenter les processus de transformation des systèmes de justice pénale internes, en particulier du procès pénal, étant donné que des mesures procédurales spéciales sont introduites pour appréhender le t

  19. Conserved TCP domain of Sas-4/CPAP is essential for pericentriolar material tethering during centrosome biogenesis.

    Science.gov (United States)

    Zheng, Xiangdong; Gooi, Li Ming; Wason, Arpit; Gabriel, Elke; Mehrjardi, Narges Zare; Yang, Qian; Zhang, Xingrun; Debec, Alain; Basiri, Marcus L; Avidor-Reiss, Tomer; Pozniakovsky, Andrei; Poser, Ina; Saric, Tomo; Hyman, Anthony A; Li, Haitao; Gopalakrishnan, Jay

    2014-01-21

    Pericentriolar material (PCM) recruitment to centrioles forms a key step in centrosome biogenesis. Deregulation of this process leads to centrosome aberrations causing disorders, one of which is autosomal recessive primary microcephaly (MCPH), a neurodevelopmental disorder where brain size is reduced. During PCM recruitment, the conserved centrosomal protein Sas-4/CPAP/MCPH6, known to play a role in centriole formation, acts as a scaffold for cytoplasmic PCM complexes to bind and then tethers them to centrioles to form functional centrosomes. To understand Sas-4's tethering role, we determined the crystal structure of its T complex protein 10 (TCP) domain displaying a solvent-exposed single-layer of β-sheets fold. This unique feature of the TCP domain suggests that it could provide an "extended surface-like" platform to tether the Sas-4-PCM scaffold to a centriole. Functional studies in Drosophila, human cells, and human induced pluripotent stem cell-derived neural progenitor cells were used to test this hypothesis, where point mutations within the 9-10th β-strands (β9-10 mutants including a MCPH-associated mutation) perturbed PCM tethering while allowing Sas-4/CPAP to scaffold cytoplasmic PCM complexes. Specifically, the Sas-4 β9-10 mutants displayed perturbed interactions with Ana2, a centrosome duplication factor, and Bld-10, a centriole microtubule-binding protein, suggesting a role for the β9-10 surface in mediating protein-protein interactions for efficient Sas-4-PCM scaffold centriole tethering. Hence, we provide possible insights into how centrosomal protein defects result in human MCPH and how Sas-4 proteins act as a vehicle to tether PCM complexes to centrioles independent of its well-known role in centriole duplication.

  20. New Shortwave Array Spectroradiometer-Hemispheric (SAS-He): Hyperspectral Design and Initial Applications

    Energy Technology Data Exchange (ETDEWEB)

    Kassianov, Evgueni I.; Flynn, Connor J M.; Barnard, James C.; Ermold, Brian D.; Berg, Larry K.

    2016-10-31

    Aerosol optical depth (AOD) derived from hyperspectral measurements can serve as an invaluable input for simultaneous retrievals of particle size distributions and major trace gases. The required hyperspectral measurements are provided by a new ground-based radiometer, the so-called Shortwave Array Spectroradiometer-Hemispheric (SAS-He), recently developed with support from the Department of Energy (DOE) Office Atmospheric Radiation Measurement (ARM) Program. The SAS-He has wide spectral coverage (350-1700nm) and high spectral resolution: about 2.4 nm and 6 nm within 350-1000 nm and 970-1700 nm spectral ranges, respectively. To illustrate an initial performance of the SAS-He, we take advantage of integrated dataset collected during the ARM-supported Two-Column Aerosol Project (TCAP) over the US coastal region (Cape Cod, Massachusetts). This dataset includes AODs derived using data from Aerosol Robotic Network (AERONET) sunphotometer and Multi-Filter Rotating Shadowband Radiometer (MFRSR). We demonstrate that, on average, the SAS-He AODs closely match the MFRSR and AERONET AODs in the ultraviolet and visible spectral ranges for this area with highly variable AOD. Also, we discuss corrections of SAS-He total optical depth for gas absorption in the near-infrared spectral range and their operational implementation.

  1. SAS/IntrNet功能简介及初步应用

    Institute of Scientific and Technical Information of China (English)

    杨舒静; 刘沛

    2014-01-01

    目的 介绍统计分析软件(statistical analysis system,SAS)网络化模块(SAS/IntrNet)的基本功能并应用于医学实际.方法 应用SAS/IntrNet远程调用SAS程序进行在线分析,从客户端获取参数通过网络传递给服务器端的SAS程序进行分析,并反馈结果给客户端.结果 利用SAS/IntrNet程序处理流程和相关配置文件,成功地实现了在线膳食暴露评估分析实例,使得用户可以在不安装SAS软件的情况下方便地通过网页进行在线SAS统计分析.结论 利用SAS/IntrNet模块实现SAS网络化应用,可使不甚了解SAS编程的使用者通过友好的访问界面即可实现SAS的在线统计分析,大大提高了SAS系统信息共享的能力.

  2. Centriolar SAS-7 acts upstream of SPD-2 to regulate centriole assembly and pericentriolar material formation.

    Science.gov (United States)

    Sugioka, Kenji; Hamill, Danielle R; Lowry, Joshua B; McNeely, Marie E; Enrick, Molly; Richter, Alyssa C; Kiebler, Lauren E; Priess, James R; Bowerman, Bruce

    2017-01-16

    The centriole/basal body is a eukaryotic organelle that plays essential roles in cell division and signaling. Among five known core centriole proteins, SPD-2/Cep192 is the first recruited to the site of daughter centriole formation and regulates the centriolar localization of the other components in C. elegans and in humans. However, the molecular basis for SPD-2 centriolar localization remains unknown. Here we describe a new centriole component, the coiled-coil protein SAS-7, as a regulator of centriole duplication, assembly and elongation. We also show that SAS-7 binds SPD-2 and regulates SPD-2 centriolar recruitment, while SAS-7 centriolar localization is SPD-2-independent. Furthermore, pericentriolar material (PCM) formation is abnormal in sas-7 mutants, and the PCM-dependent induction of cell polarity that defines the anterior-posterior body axis frequently fails. We conclude that SAS-7 functions at the earliest step in centriole duplication yet identified and plays important roles in the orchestration of centriole and PCM assembly.

  3. Determination and occurrence of secondary alkane sulfonates (SAS) in aquatic environments.

    Science.gov (United States)

    Baena-Nogueras, Rosa María; González-Mazo, Eduardo; Lara-Martín, Pablo A

    2013-05-01

    A new methodology has been developed for the determination of secondary alkane sulfonates (SAS), an anionic surfactant, in environmental matrices. Sediment and sludge samples were extracted using pressurized liquid extraction and sonication, whereas wastewater and surface water samples were processed using solid-phase extraction. Extraction recoveries were acceptable for both aqueous (78-120%) and solid samples (83-100%). Determination of SAS was carried out by high or ultra performance liquid chromatography - mass spectrometry using ion trap and time-of-flight detectors. The methodology was applied to samples from Guadalete River (SW Spain), where SAS concentrations below 1 μg L(-1) were measured in surface water, and from 72 to 9737 μg kg(-1) in sediments. Differential partitioning was observed for SAS homologues as those having a longer hydrocarbon chain which preferentially sorbed onto particulate matter. A preliminary environmental risk assessment also showed that SAS measured levels were not harmful to the aquatic community in the sampling area.

  4. Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome.

    Science.gov (United States)

    Gopalakrishnan, Jayachandran; Mennella, Vito; Blachon, Stephanie; Zhai, Bo; Smith, Andrew H; Megraw, Timothy L; Nicastro, Daniela; Gygi, Steven P; Agard, David A; Avidor-Reiss, Tomer

    2011-06-21

    Centrosomes are conserved organelles that are essential for accurate cell division and cilium formation. A centrosome consists of a pair of centrioles surrounded by a protein network of pericentriolar material (PCM) that is essential for the centrosome's function. In this study, we show that Sas-4 provides a scaffold for cytoplasmic complexes (named S-CAP), which include CNN, Asl and D-PLP, proteins that are all found in the centrosomes at the vicinity of the centriole. When Sas-4 is absent, nascent procentrioles are unstable and lack PCM, and functional centrosomes are not generated. When Sas-4 is mutated, so that it cannot form S-CAP complexes, centrosomes are present but with dramatically reduced levels of PCM. Finally, purified S-CAP complexes or recombinant Sas-4 can bind centrosomes stripped of PCM, whereas recombinant CNN or Asl cannot. In summary, PCM assembly begins in the cytosol where Sas-4 provides a scaffold for pre-assembled cytoplasmic complexes before tethering of the complexes in a centrosome.

  5. SAS-Pro: simultaneous residue assignment and structure superposition for protein structure alignment.

    Science.gov (United States)

    Shah, Shweta B; Sahinidis, Nikolaos V

    2012-01-01

    Protein structure alignment is the problem of determining an assignment between the amino-acid residues of two given proteins in a way that maximizes a measure of similarity between the two superimposed protein structures. By identifying geometric similarities, structure alignment algorithms provide critical insights into protein functional similarities. Existing structure alignment tools adopt a two-stage approach to structure alignment by decoupling and iterating between the assignment evaluation and structure superposition problems. We introduce a novel approach, SAS-Pro, which addresses the assignment evaluation and structure superposition simultaneously by formulating the alignment problem as a single bilevel optimization problem. The new formulation does not require the sequentiality constraints, thus generalizing the scope of the alignment methodology to include non-sequential protein alignments. We employ derivative-free optimization methodologies for searching for the global optimum of the highly nonlinear and non-differentiable RMSD function encountered in the proposed model. Alignments obtained with SAS-Pro have better RMSD values and larger lengths than those obtained from other alignment tools. For non-sequential alignment problems, SAS-Pro leads to alignments with high degree of similarity with known reference alignments. The source code of SAS-Pro is available for download at http://eudoxus.cheme.cmu.edu/saspro/SAS-Pro.html.

  6. New Shortwave Array Spectroradiometer-Hemispheric (SAS-He): hyperspectral design and initial applications

    Science.gov (United States)

    Kassianov, Evgueni; Flynn, Connor; Barnard, James; Ermold, Brian; Berg, Larry

    2016-10-01

    Aerosol optical depth (AOD) derived from hyperspectral measurements can serve as an invaluable input for simultaneous retrievals of particle size distributions and major trace gases. The required hyperspectral measurements are provided by a new ground-based radiometer, the so-called Shortwave Array Spectroradiometer-Hemispheric (SAS-He), recently developed with support from the Department of Energy (DOE) Office Atmospheric Radiation Measurement (ARM) Program. The SAS-He has wide spectral coverage (350-1700nm) and high spectral resolution: about 2.4 nm and 6 nm within 350-1000 nm and 970-1700 nm spectral ranges, respectively. To illustrate an initial performance of the SAS-He, we take advantage of integrated dataset collected during the ARM-supported Two-Column Aerosol Project (TCAP) over the US coastal region (Cape Cod, Massachusetts). This dataset includes AODs derived using data from Aerosol Robotic Network (AERONET) sunphotometer and Multi-Filter Rotating Shadowband Radiometer (MFRSR). We demonstrate that, on average, the SAS-He AODs closely match the MFRSR and AERONET AODs in the ultraviolet and visible spectral ranges for this area with highly variable AOD. Also, we discuss corrections of SAS-He total optical depth for gas absorption in the near-infrared spectral range and their operational implementation

  7. Spanish Validation of the School Anxiety Scale-Teacher Report (SAS-TR).

    Science.gov (United States)

    Orgilés, Mireia; Fernández-Martínez, Iván; Lera-Miguel, Sara; Marzo, Juan Carlos; Medrano, Laura; Espada, José Pedro

    2016-11-04

    This study aimed to examine the factorial structure and psychometric properties of the School Anxiety Scale-Teacher Report (SAS-TR) in a community sample of 315 Spanish children aged 5 to 12 years. Thirty-seven teachers from eleven schools completed the SAS-TR and the Strengths and Difficulties Questionnaire (SDQ) for each child. Confirmatory factor analysis supported the original two-factor structure, but a better fit model was obtained after removing four items. The scale was found to have high internal consistency (α = 0.91) and satisfactory test-retest reliability (ICC = 0.87) for the Spanish sample. Convergent validity was supported by positive significant correlations between the SAS-TR and the Emotional Symptoms subscale of the SDQ. Lower correlations between the SAS-TR and the SDQ Conduct Problems subscale supported the divergent validity. Overall, the findings suggest that the Spanish version of the SAS-TR is a reliable and valid instrument for teachers to assess anxiety in Spanish children.

  8. 基于SAS/IntrNet的预测系统实现%Implementation of Forecasting System Based on SAS/IntrNet

    Institute of Scientific and Technical Information of China (English)

    谢红

    2008-01-01

    SAS是一个使用广泛的大型模块化的应用软件系统,具有强大的数据分析和管理能力.文章以预测系统的实现为例,介绍如何使用SAS/IntrNet组件,实现SAS和J2EEWEB技术的结合.

  9. The SAS-5 N-terminal domain is a tetramer, with implications for centriole assembly in C. elegans.

    Science.gov (United States)

    Shimanovskaya, Ekaterina; Qiao, Renping; Lesigang, Johannes; Dong, Gang

    2013-07-01

    The centriole is a conserved microtubule-based organelle essential for both centrosome formation and cilium biogenesis. It has a unique 9-fold symmetry and its assembly is governed by at least five component proteins (SPD-2, ZYG-1, SAS-5, SAS-6 and SAS-4), which are recruited in a hierarchical order. Recently published structural studies of the SAS-6 N-terminal domain have greatly advanced our understanding of the mechanisms of centriole assembly. However, it remains unclear how the weak interaction between the SAS-6 N-terminal head groups could drive the assembly of a closed ring-like structure, and what determines the stacking of multiple rings on top one another in centriole duplication. We recently reported that SAS-5 binds specifically to a very narrow region of the SAS-6 central coiled coil through its C-terminal domain (CTD, residues 391-404). Here, we further demonstrate by both static light scattering and small angle X-ray scattering that the SAS-5 N-terminal domain (NTD, residues 1-260) forms a tetramer. Specifically, we found that the tetramer is formed by SAS-5 residues 82-260, whereas residues 1-81 are intrinsically disordered. Taking these results together, we propose a working model for SAS-5-mediated assembly of the multi-layered central tube structure.

  10. Smoothing point data into maps using SAS/GRAPH (trade name) software. Forest Service research note

    Energy Technology Data Exchange (ETDEWEB)

    Chojnacky, D.C.; Rubey, M.E.

    1996-01-01

    Point of plot data are commonly available for mapping forest landscapes. Because such data are sampled, mapping a complete coverage usually requires some type of interpolation between plots. SAS/GRAPH software includes the G3GRID procedure for interpolating or smoothing this type of data to map with G3D or GCONTOUR procedures. However, the smoothing process in G3GRID is not easily controlled, nor can it be used to display missing data within rectangular grid maps. These shortcomings motivated development of SAS code that prepares point data for display in mapping units. This code links well with the rest of the SAS system to allow for powerful, easily controlled data analysis within mapping units. Examples are given for mapping forest vegetation with the GMAP procedure.

  11. The Artful Use of SAS/OR Software for Solving Integer Linear Programming with Many Solutions%巧用SAS/OR软件求解多解整数线性规划

    Institute of Scientific and Technical Information of China (English)

    邹祥福

    2004-01-01

    通过实例讲解如何巧用SAS/OR软件求解多解整数线性规划问题的多个解,弥补了用SAS/OR软件仅能得出多解整数线性规划一个解的缺点,使SAS/OR软件有了更广阔的应用.

  12. Calendrier, représentations mentales et procédures de calcul chez les Nahuas (Mexique)

    OpenAIRE

    Chamoux, Marie-Noëlle

    2014-01-01

    Calendrier, représentations mentales et procédures de calcul chez les Nahuas (Mexique). Pour le calcul des dates de fêtes importantes se rapportant à la Toussaint ou Fête des Morts, les Nahuas de la région de Huauchinango (Puebla) utilisaient, il y a peu, un système de repères qui s’avère être une mesure exacte, à condition d’abandonner notre préjugé spontané d’une numération séquentielle et de reconstruire des représentations mentales sous-jacentes de type topologique. Le temps des « paysans...

  13. Analyse thermo énergétique d’un procédé de dessalement d’eau

    OpenAIRE

    MANDI, BENAISSA

    2014-01-01

    En Algérie, comme dans les pays en voie de développement, le problème d’approvisionnement en eau potable devient de plus en plus crucial, du fait de la croissance démographique et de l’élévation du niveau de vie. Le dessalement de l’eau de mer et des eaux saumâtres est désormais envisageable pour répondre à la demande en eau potable. Parmi les différents procédés, la distillation solaire est une solution intéressantes. L’objectif de ce travail est l’analyse thermo physique de l...

  14. Le Procès de Tôkyô, l’empereur et la question du Yasukuni*

    OpenAIRE

    Takahashi, Tetsuya

    2010-01-01

    Au Japon, toute une partie de la classe politique conservatrice persiste à refuser les conclusions du procès de Tôkyô, considérant celui-ci comme une justice « orchestrée par les vainqueurs ». Ce faisant, les partisans de cette thèse se trouvent dans une contradiction puisque l’empereur Hirohito lui-même, qui avait exprimé sa gratitude auprès des forces d’occupation américaines pour l’avoir épargné, en avait de facto admis les conclusions. Ce paradoxe pour le camp conservateur est aggravé par...

  15. Comparing fibre channel, serial attached SCSI (SAS) and serial ATA (SATA)

    OpenAIRE

    Lam, Hin Wing Allen

    2009-01-01

    Serial Attached SCSI (SAS), Serial ATA (SATA) and Fibre Channel (FC) are the main storage interconnect technologies at present. FC is the main interconnect in Storage Area Network (SAN) with a well-known high performance and strong foundation of SCSI. SATA is the most cost-effective and high capacity in the hard drive market. On the other hand, SAS is just picking-up the momentum in both storage and hard drive areas and positions itself as a potential player. All three of these technologies h...

  16. Univariate and multivariate general linear models theory and applications with SAS

    CERN Document Server

    Kim, Kevin

    2006-01-01

    Reviewing the theory of the general linear model (GLM) using a general framework, Univariate and Multivariate General Linear Models: Theory and Applications with SAS, Second Edition presents analyses of simple and complex models, both univariate and multivariate, that employ data sets from a variety of disciplines, such as the social and behavioral sciences.With revised examples that include options available using SAS 9.0, this expanded edition divides theory from applications within each chapter. Following an overview of the GLM, the book introduces unrestricted GLMs to analyze multiple regr

  17. Median and quantile tests under complex survey design using SAS and R.

    Science.gov (United States)

    Pan, Yi; Caudill, Samuel P; Li, Ruosha; Caldwell, Kathleen L

    2014-11-01

    Techniques for conducting hypothesis testing on the median and other quantiles of two or more subgroups under complex survey design are limited. In this paper, we introduce programs in both SAS and R to perform such a test. A detailed illustration of the computations, macro variable definitions, input and output for the SAS and R programs are also included in the text. Urinary iodine data from National Health and Nutrition Examination Survey (NHANES) are used as examples for comparing medians between females and males as well as comparing the 75th percentiles among three salt consumption groups.

  18. A SAS-macro for estimation of the cumulative incidence using Poisson regression

    DEFF Research Database (Denmark)

    Waltoft, Berit Lindum

    2009-01-01

    the hazard rates, and the hazard rates are often estimated by the Cox regression. This procedure may not be suitable for large studies due to limited computer resources. Instead one uses Poisson regression, which approximates the Cox regression. Rosthøj et al. presented a SAS-macro for the estimation...... of the cumulative incidences based on the Cox regression. I present the functional form of the probabilities and variances when using piecewise constant hazard rates and a SAS-macro for the estimation using Poisson regression. The use of the macro is demonstrated through examples and compared to the macro presented...

  19. Encadrement des produits et des procédés : réglementation et normalisation du commerce international

    Directory of Open Access Journals (Sweden)

    Morin Odile

    2003-07-01

    Full Text Available Produits et procédés sont encadrés à la fois par des réglementations et, à un autre niveau, par des normes du commerce international. Cette présentation traite des textes réglementaires au niveau communautaire et national. On rappellera que l’entrée en vigueur d’un règlement européen est suivie d’une transposition dans le droit de chaque pays membre et que la réglementation nationale s’applique en l’absence de dispositions communautaires. En matière de commerce international, seront évoquées les actions de normalisation du Conseil Oléicole International (COI pour les huiles d’olive et de grignons d’olive et celles du Codex Alimentarius pour les huiles et graisses comestibles. L’ensemble des dispositions réglementaires constitue un cadre englobant les productions de l’amont vers l’aval, à la fois sur un plan vertical (oléagineux, huiles et corps gras, huiles d’olive, margarines, procédés de raffinage et transversalement (composés organiques volatils, OGM, solvants d’extraction, additifs, contaminants…. Le cas de l’huile d’olive est particulier en ce qu’il bénéficie d’un encadrement au niveau international (normes commerciales COI et Codex Alimentarius, européen et national (réglementation. Le Codex Alimentarius, quant à lui, établit des normes à caractère vertical (huiles végétales, graisses animales, huiles d’olive, matières grasses tartinables… et horizontal (additifs, résidus de pesticides…. L’essentiel de cet encadrement est résumé dans les tableaux qui illustrent cette contribution.

  20. Testing the Short and Screener versions of the Social Adjustment Scale-Self-report (SAS-SR).

    Science.gov (United States)

    Gameroff, Marc J; Wickramaratne, Priya; Weissman, Myrna M

    2012-03-01

    The 54-item Social Adjustment Scale-Self-report (SAS-SR) is a measure of social functioning used in research studies and clinical practice. Two shortened versions were recently developed: the 24-item SAS-SR: Short and the 14-item SAS-SR: Screener. We briefly describe the development of the shortened scales and then assess their reliability and validity in comparison to the full SAS-SR in new analyses from two separate samples of convenience from a family study and from a primary care clinic. Compared to the full SAS-SR, the shortened scales performed well, exhibiting high correlations with full SAS-SR scores (r values between 0.81 and 0.95); significant correlations with health-related quality of life as measured by the Short Form 36 Health Survey; the ability to distinguish subjects with major depression versus other psychiatric disorders versus no mental disorders; and sensitivity to change in clinical status as measured longitudinally with the Symptom Checklist-90 and Global Assessment Scale. The SAS-SR: Short and SAS-SR: Screener retained the areas assessed by the full SAS-SR with fewer items in each area, and appear to be promising replacements for the full scale when a shorter administration time is desired and detailed information on performance in different areas is not required. Further work is needed to test the validity of the shortened measures.

  1. SAS-4 Protein in Trypanosoma brucei Controls Life Cycle Transitions by Modulating the Length of the Flagellum Attachment Zone Filament.

    Science.gov (United States)

    Hu, Huiqing; Zhou, Qing; Li, Ziyin

    2015-12-18

    The evolutionarily conserved centriole/basal body protein SAS-4 regulates centriole duplication in metazoa and basal body duplication in flagellated and ciliated organisms. Here, we report that the SAS-4 homolog in the flagellated protozoan Trypanosoma brucei, TbSAS-4, plays an unusual role in controlling life cycle transitions by regulating the length of the flagellum attachment zone (FAZ) filament, a specialized cytoskeletal structure required for flagellum adhesion and cell morphogenesis. TbSAS-4 is concentrated at the distal tip of the FAZ filament, and depletion of TbSAS-4 in the trypomastigote form disrupts the elongation of the new FAZ filament, generating cells with a shorter FAZ associated with a longer unattached flagellum and repositioned kinetoplast and basal body, reminiscent of epimastigote-like morphology. Further, we show that TbSAS-4 associates with six additional FAZ tip proteins, and depletion of TbSAS-4 disrupts the enrichment of these FAZ tip proteins at the new FAZ tip, suggesting a role of TbSAS-4 in maintaining the integrity of this FAZ tip protein complex. Together, these results uncover a novel function of TbSAS-4 in regulating the length of the FAZ filament to control basal body positioning and life cycle transitions in T. brucei.

  2. The Centriole Cartwheel Protein SAS-6 in Trypanosoma brucei Is Required for Probasal Body Biogenesis and Flagellum Assembly.

    Science.gov (United States)

    Hu, Huiqing; Liu, Yi; Zhou, Qing; Siegel, Sara; Li, Ziyin

    2015-09-01

    The centriole in eukaryotes functions as the cell's microtubule-organizing center (MTOC) to nucleate spindle assembly, and its biogenesis requires an evolutionarily conserved protein, SAS-6, which assembles the centriole cartwheel. Trypanosoma brucei, an early branching protozoan, possesses the basal body as its MTOC to nucleate flagellum biogenesis. However, little is known about the components of the basal body and their roles in basal body biogenesis and flagellum assembly. Here, we report that the T. brucei SAS-6 homolog, TbSAS-6, is localized to the mature basal body and the probasal body throughout the cell cycle. RNA interference (RNAi) of TbSAS-6 inhibited probasal body biogenesis, compromised flagellum assembly, and caused cytokinesis arrest. Surprisingly, overexpression of TbSAS-6 in T. brucei also impaired probasal body duplication and flagellum assembly, contrary to SAS-6 overexpression in humans, which produces supernumerary centrioles. Furthermore, we showed that depletion of T. brucei Polo-like kinase, TbPLK, or inhibition of TbPLK activity did not abolish TbSAS-6 localization to the basal body, in contrast to the essential role of Polo-like kinase in recruiting SAS-6 to centrioles in animals. Altogether, these results identified the essential role of TbSAS-6 in probasal body biogenesis and flagellum assembly and suggest the presence of a TbPLK-independent pathway governing basal body duplication in T. brucei.

  3. SAS võib omapoolse panusena kustutada osa Estonian Airi laenust / Gert D. Hankewitz

    Index Scriptorium Estoniae

    Hankewitz, Gert D.

    2011-01-01

    Lennufirma SAS investorsuhete asepresidendi Sture Stoleni sõnul ei ole tõenäoline, et nende firma maksaks mingit raha Estonian Airi kapitali, küll aga ei saa välistada võimalust, et võidakse kustutada osa antud laenust

  4. Essentials of Excel, Excel VBA, SAS and Minitab for statistical and financial analyses

    CERN Document Server

    Lee, Cheng-Few; Chang, Jow-Ran; Tai, Tzu

    2016-01-01

    This introductory textbook for business statistics teaches statistical analysis and research methods via business case studies and financial data using Excel, MINITAB, and SAS. Every chapter in this textbook engages the reader with data of individual stock, stock indices, options, and futures. One studies and uses statistics to learn how to study, analyze, and understand a data set of particular interest. Some of the more popular statistical programs that have been developed to use statistical and computational methods to analyze data sets are SAS, SPSS, and MINITAB. Of those, we look at MINITAB and SAS in this textbook. One of the main reasons to use MINITAB is that it is the easiest to use among the popular statistical programs. We look at SAS because it is the leading statistical package used in industry. We also utilize the much less costly and ubiquitous Microsoft Excel to do statistical analysis, as the benefits of Excel have become widely recognized in the academic world and its analytical capabilities...

  5. A new SAS program for behavioral analysis of Electrical Penetration Graph (EPG) data

    Science.gov (United States)

    A new program is introduced that uses SAS software to duplicate output of descriptive statistics from the Sarria Excel workbook for EPG waveform analysis. Not only are publishable means and standard errors or deviations output, the user also is guided through four relatively simple sub-programs for ...

  6. Measuring Statistics Anxiety: Cross-Country Validity of the Statistical Anxiety Scale (SAS)

    Science.gov (United States)

    Chiesi, Francesca; Primi, Caterina; Carmona, Jose

    2011-01-01

    The aim of the research was to test the psychometric properties of the Italian version of the Vigil-Colet et al.'s Statistical Anxiety Scale (SAS), taking into account evidences based on (a) internal structure (factorial structure and cross-country invariance) and (b) relationships to other variables (the statistics anxiety's nomological network).…

  7. Kuue riigi tudengid mängivad Radisson SAS hotelli juhatust / Agne Narusk

    Index Scriptorium Estoniae

    Narusk, Agne

    2003-01-01

    90 soome, eesti, ungari, prantsusmaa, hollandi ja belgia tudengit kehastuvad Radisson SAS hotellide rahvusvahelise juhatuse liikmeteks ja esitavad kujuteldavale aktsionäride üldkoosolekule nägemuse uutest võimalikest hotellidest. Hotelliülesanded koostas Eesti Kõrgema Kommertskooli (EBS) ettevõtluse õppetooli lektor Elena Pruvli

  8. SAS pani Estonian Airi aktsiad müüki / Riina Kallas, Tuuli Aug

    Index Scriptorium Estoniae

    Kallas, Riina

    2009-01-01

    SAS müüb enamusosaluse Estonian Airis ja veel kuues tütarfirmas, majandus- ja kommunikatsiooniminister Juhan Parts näeb Estonian Airi uue osanikuna mõnda Eesti investorit. Endise Estonian Airi presidendi Erki Urva arvamus

  9. SAS-2 high-energy gamma-ray observations of the Vela pulsar. II

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Kniffen, D. A.; Ogelman, H. B.

    1977-01-01

    Analysis of additional data from SAS-2 experiment and improvements in the orbit-attitude data and analysis procedures have produced revised values for the flux from the Vela gamma-ray source. The pulsar phase plot shows two peaks, neither of which is in phase with the single radio pulse.

  10. Estudi i millora del procés de fabricació d’emblemes per al sector d’automoció

    OpenAIRE

    Zamora Putin, Esther

    2015-01-01

    Aquest Projecte de Fi de Carrera tracta sobre el procés de fabricació de la lent Fiat, un emblema del sector de l’automoció fet amb polimetilmetactrilat. Els processos principals dels que està composat són injecció, tampografia pintura muntatge i empaquetat; que es descriuen en detall en aquest treball. L’objectiu d’aquest treball és estudiar la situació inicial del procés de fabricació per proposar-ne millores. Les eines emprades per a realitzar aquest anàlisi són les que proporciona el L...

  11. Plasma Pro-C3 (N-terminal type III collagen propeptide) predicts fibrosis progression in patients with chronic hepatitis C

    DEFF Research Database (Denmark)

    Nielsen, Mette J.; Veidal, Sanne S.; Karsdal, Morten A.

    2015-01-01

    BACKGROUND & AIMS: Fibrogenesis results in release of certain extracellular matrix protein fragments into the circulation. We evaluated the diagnostic and prognostic performance of two novel serological markers, the precisely cleaved N-terminal propeptide of type III collagen (Pro-C3) and a peptide...... of helical collagen type III degradation (C3M), in chronic hepatitis C (CHC) patients. METHOD: Pro-C3 and C3M were measured by ELISA in plasma from CHC patients (n = 194) from a prior phase II antifibrotic trial (NCT00244751). Plasma samples and paired liver biopsies were obtained at baseline and after 1...

  12. Clinical SAS programming in India: A study of industry needs versus wants

    Directory of Open Access Journals (Sweden)

    Nithiyanandhan Ananthakrishnan

    2014-01-01

    Full Text Available Background: The clinical SAS (www.sas.com programming industry, in India, has seen a rapid growth in the last decade and the trend seems set to continue, for the next couple of years, due to cost advantage and the availability of skilled labor. On one side the industry needs are focused on less execution time, high margins, segmented tasks and the delivery of high quality output with minimal oversight. On the other side, due to the increased demand for skilled resources, the wants of the programmers have taken a different shift toward diversifying exposure, unsustainable wage inflation due to multiple opportunities and generally high expectations around career progression. If the industry needs are not going to match with programmers want, or vice versa, then there is the possibility that the current year on year growth may start to slow or even go into decline. Aim: This paper is intended to identify the gap between wants and need and puts forwards some suggestions, for both sides, in ways to change the equation to benefit all. Settings and Design: Questionnaire on similar themes created to survey managers and programmers working in clinical SAS programming industry and was surveyed online to collect their perspectives. Their views are compared for each theme and presented as results. Materials and Methods: Two surveys were created in www.surveymonkey.com. Management: https://www.surveymonkey.com/s/SAS_India_managment_needvswant_survey. Programmer: https://www.surveymonkey.com/s/SAS_India_programmer_needvswant_survey. Statistical Analysis Used: Bar chart and pie chart used on data collect to show segmentation of data. Results and Conclusions: In conclusion, it seeks to highlight the future industry direction and the skillset that existing programmers need to have, in order to sustain the momentum and remain competitive, to contribute to the future pipeline and the development of the profession in India.

  13. The SAS4A/SASSYS-1 Safety Analysis Code System, Version 5

    Energy Technology Data Exchange (ETDEWEB)

    Fanning, T. H. [Argonne National Lab. (ANL), Argonne, IL (United States); Brunett, A. J. [Argonne National Lab. (ANL), Argonne, IL (United States); Sumner, T. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-01-01

    The SAS4A/SASSYS-1 computer code is developed by Argonne National Laboratory for thermal, hydraulic, and neutronic analysis of power and flow transients in liquidmetal- cooled nuclear reactors (LMRs). SAS4A was developed to analyze severe core disruption accidents with coolant boiling and fuel melting and relocation, initiated by a very low probability coincidence of an accident precursor and failure of one or more safety systems. SASSYS-1, originally developed to address loss-of-decay-heat-removal accidents, has evolved into a tool for margin assessment in design basis accident (DBA) analysis and for consequence assessment in beyond-design-basis accident (BDBA) analysis. SAS4A contains detailed, mechanistic models of transient thermal, hydraulic, neutronic, and mechanical phenomena to describe the response of the reactor core, its coolant, fuel elements, and structural members to accident conditions. The core channel models in SAS4A provide the capability to analyze the initial phase of core disruptive accidents, through coolant heat-up and boiling, fuel element failure, and fuel melting and relocation. Originally developed to analyze oxide fuel clad with stainless steel, the models in SAS4A have been extended and specialized to metallic fuel with advanced alloy cladding. SASSYS-1 provides the capability to perform a detailed thermal/hydraulic simulation of the primary and secondary sodium coolant circuits and the balance-ofplant steam/water circuit. These sodium and steam circuit models include component models for heat exchangers, pumps, valves, turbines, and condensers, and thermal/hydraulic models of pipes and plena. SASSYS-1 also contains a plant protection and control system modeling capability, which provides digital representations of reactor, pump, and valve controllers and their response to input signal changes.

  14. Les procès d’animaux en Lorraine (XIVe-XVIIIe siècles

    Directory of Open Access Journals (Sweden)

    Laurent Litzenburger

    2011-12-01

    Full Text Available Les archives lorraines et barroises livrent, en l’état actuel de la recherche, trente-quatre mentions de procès d’animaux et d’insectes, qui s’inscrivent dans une fourchette chronologique assez large, débutant vers le milieu du XIVe siècle et s’achevant dans le premier tiers du XVIIIe siècle. De tels procès ont eu lieu dans tout l’Occident chrétien à partir du milieu du XIIIe siècle. Les exemples sont toutefois rares, ce qui a longtemps fait dire aux historiens que ces affaires ne sont que des épiphénomènes trahissant certains archaïsmes judiciaires des sociétés anciennes. Pour comprendre ce phénomène, il est nécessaire de s’interroger sur le contexte culturel qui le rend possible. Celui-ci s’inscrit dans la longue durée, de l’antiquité jusqu’au renouveau de la pensée humaniste et à l’éclosion de l’esprit des Lumières. Comment expliquer que, pendant toute cette période, les sociétés trouvèrent tout à fait raisonnable de traduire animaux et insectes devant la justice ?Lorraine and Barrois archives deliver – in the current state of research – thirty-four mentions of animals and insects trials that are part of a broad chronological range, beginning in the mid-fourteenth century and finishing during the first third of the eighteenth century. Such trials took place across the Christian West since the mid-thirteenth century. Examples are rare and were long been considered by historians as a epiphenomena, betraying some archaism of ancient societies. To understand this phenomenon, it is necessary to consider the cultural context that makes it possible. This is part of the long-term revival of antiquity to the humanist tought and the emergence of the Enlightenment. How to explain that, during these period, societies found it perfectly reasonable to prosecute animals and insects?

  15. Coupling the System Analysis Module with SAS4A/SASSYS-1

    Energy Technology Data Exchange (ETDEWEB)

    Fanning, T. H. [Argonne National Lab. (ANL), Argonne, IL (United States); Hu, R. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-09-30

    SAS4A/SASSYS-1 is a simulation tool used to perform deterministic analysis of anticipated events as well as design basis and beyond design basis accidents for advanced reactors, with an emphasis on sodium fast reactors. SAS4A/SASSYS-1 has been under development and in active use for nearly forty-five years, and is currently maintained by the U.S. Department of Energy under the Office of Advanced Reactor Technology. Although SAS4A/SASSYS-1 contains a very capable primary and intermediate system modeling component, PRIMAR-4, it also has some shortcomings: outdated data management and code structure makes extension of the PRIMAR-4 module somewhat difficult. The user input format for PRIMAR-4 also limits the number of volumes and segments that can be used to describe a given system. The System Analysis Module (SAM) is a fairly new code development effort being carried out under the U.S. DOE Nuclear Energy Advanced Modeling and Simulation (NEAMS) program. SAM is being developed with advanced physical models, numerical methods, and software engineering practices; however, it is currently somewhat limited in the system components and phenomena that can be represented. For example, component models for electromagnetic pumps and multi-layer stratified volumes have not yet been developed. Nor is there support for a balance of plant model. Similarly, system-level phenomena such as control-rod driveline expansion and vessel elongation are not represented. This report documents fiscal year 2016 work that was carried out to couple the transient safety analysis capabilities of SAS4A/SASSYS-1 with the system modeling capabilities of SAM under the joint support of the ART and NEAMS programs. The coupling effort was successful and is demonstrated by evaluating an unprotected loss of flow transient for the Advanced Burner Test Reactor (ABTR) design. There are differences between the stand-alone SAS4A/SASSYS-1 simulations and the coupled SAS/SAM simulations, but these are mainly

  16. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT-A AND A ENVIRONMENTAL SEALS, INC., SEAL ASSIST SYSTEM (SAS) PHASE II REPORT

    Science.gov (United States)

    The Environmental Technology Verification report discusses the technology and performance of Seal Assist System (SAS) for natural gas reciprocating compressor rod packing manufactured by A&A Environmental Seals, Inc. The SAS uses a secondary containment gland to collect natural g...

  17. Houston, We Have a Problem: Teachers Find No Value in the SAS Education Value-Added Assessment System (EVAAS®)

    Science.gov (United States)

    Collins, Clarin

    2014-01-01

    This study examined the SAS Education Value-Added Assessment System (EVAAS®) in practice, as perceived and experienced by teachers in the Southwest School District (SSD). To evaluate teacher effectiveness, SSD is using SAS EVAAS® for high-stakes consequences more than any other district or state in the country. A mixed-method design including a…

  18. Optimisation de fonctionnements de pompe à chaleur chimique : synchronisation et commande du procédé

    Science.gov (United States)

    Cassou, T.; Amouroux, M.; Labat, P.

    1995-04-01

    We present the mathematical modelling of a chemical heat pump and the associated simulator. This simulator is able to determine the influence of different parameters (which would be associated to the heat exchanges or to the chemical kinetics), but also to simulate the main operating modes. An optimal management of process represents the objective to reach; we materialize it by a continuous and steady production of the power delivered by the machine. Nous présentons le modèle mathématique d'un pilote de pompe à chaleur chimique et le simulateur numérique correspondant. Ce simulateur est capable de déterminer l'influence de divers paramètres (qu'ils soient liés aux échanges de chaleur ou à la cinétique chimique), mais aussi de simuler les principaux modes de fonctionnement. Une gestion optimale du procédé représente le but à atteindre: une conduite optimisée du système permet, par une gestion des différentes phases, une production continue et stable de la puissance délivrée par la machine.

  19. Unsteady Simulations of the Flow in a Channel Flow and a Ventilated Room Using the SST-SAS Model

    DEFF Research Database (Denmark)

    Davidson, Lars; Nielsen, Peter V.

    -SAS model is evaluated for two flows: developing channel flow and the flow in a three-dimensional ventilated room. Unsteady inlet boundary conditions are prescribed in both cases by superimposing isotropic synthetic fluctuations on a steady inlet boundary velocity profile.......The SAS model (Scale Adapted Simulation) was invented by Menter and his co-workers. The idea behind the SST-SAS model is to add an additional production term - the SAS term - in the w equation which is sensitive to resolved (i.e. unsteady) fluctuations. In regions where the flow is on the limit...... of going unsteady, the object of the SAS term is to increase w. The result is that k and vt are reduced so that the dissipating (damping) effect of the turbulent viscosity on the resolved fluctuations is reduced, thereby promoting the momentum equations to switch from steady to unsteady mode. The SST...

  20. SAS macro programs for geographically weighted generalized linear modeling with spatial point data: applications to health research.

    Science.gov (United States)

    Chen, Vivian Yi-Ju; Yang, Tse-Chuan

    2012-08-01

    An increasing interest in exploring spatial non-stationarity has generated several specialized analytic software programs; however, few of these programs can be integrated natively into a well-developed statistical environment such as SAS. We not only developed a set of SAS macro programs to fill this gap, but also expanded the geographically weighted generalized linear modeling (GWGLM) by integrating the strengths of SAS into the GWGLM framework. Three features distinguish our work. First, the macro programs of this study provide more kernel weighting functions than the existing programs. Second, with our codes the users are able to better specify the bandwidth selection process compared to the capabilities of existing programs. Third, the development of the macro programs is fully embedded in the SAS environment, providing great potential for future exploration of complicated spatially varying coefficient models in other disciplines. We provided three empirical examples to illustrate the use of the SAS macro programs and demonstrated the advantages explained above.

  1. Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry.

    Science.gov (United States)

    Hilbert, Manuel; Erat, Michèle C; Hachet, Virginie; Guichard, Paul; Blank, Iris D; Flückiger, Isabelle; Slater, Leanne; Lowe, Edward D; Hatzopoulos, Georgios N; Steinmetz, Michel O; Gönczy, Pierre; Vakonakis, Ioannis

    2013-07-09

    Centrioles are evolutionary conserved organelles that give rise to cilia and flagella as well as centrosomes. Centrioles display a characteristic ninefold symmetry imposed by the spindle assembly abnormal protein 6 (SAS-6) family. SAS-6 from Chlamydomonas reinhardtii and Danio rerio was shown to form ninefold symmetric, ring-shaped oligomers in vitro that were similar to the cartwheels observed in vivo during early steps of centriole assembly in most species. Here, we report crystallographic and EM analyses showing that, instead, Caenorhabotis elegans SAS-6 self-assembles into a spiral arrangement. Remarkably, we find that this spiral arrangement is also consistent with ninefold symmetry, suggesting that two distinct SAS-6 oligomerization architectures can direct the same output symmetry. Sequence analysis suggests that SAS-6 spirals are restricted to specific nematodes. This oligomeric arrangement may provide a structural basis for the presence of a central tube instead of a cartwheel during centriole assembly in these species.

  2. Aerosol Optical Depth Value-Added Product for the SAS-He Instrument

    Energy Technology Data Exchange (ETDEWEB)

    Ermold, B [Pacific Northwest National Laboratory; Flynn, CJ [Pacific Northwest National Laboratory; Barnard, J [University of Nevada Reno

    2013-11-27

    The Shortwave Array Spectroradiometer – Hemispheric (SAS-He) is a ground-based, shadowband instrument that measures the direct and diffuse solar irradiance. In this regard, the instrument is similar to the Multi-Filter Rotating Shadowband Radiometer (MFRSR) – an instrument that has been in the ARM suite of instruments for more than 15 years. However, the two instruments differ significantly in wavelength resolution and range. In particular, the MFRSR only observes the spectrum in six discrete wavelength channels of about 10 nm width from 415 to 940 nm. The SAS-He, in contrast, incorporates two fiber-coupled grating spectrometers: a Si CCD spectrometer with over 2000 pixels covering the range from 325-1040 nm with ~ 2.5 nm resolution ,and an InGaAs array spectrometer with 256 pixels covering the wavelength range from 960-1700 nm with ~ 6 nm resolution.

  3. SPSS and SAS programs for comparing Pearson correlations and OLS regression coefficients.

    Science.gov (United States)

    Weaver, Bruce; Wuensch, Karl L

    2013-09-01

    Several procedures that use summary data to test hypotheses about Pearson correlations and ordinary least squares regression coefficients have been described in various books and articles. To our knowledge, however, no single resource describes all of the most common tests. Furthermore, many of these tests have not yet been implemented in popular statistical software packages such as SPSS and SAS. In this article, we describe all of the most common tests and provide SPSS and SAS programs to perform them. When they are applicable, our code also computes 100 × (1 - α)% confidence intervals corresponding to the tests. For testing hypotheses about independent regression coefficients, we demonstrate one method that uses summary data and another that uses raw data (i.e., Potthoff analysis). When the raw data are available, the latter method is preferred, because use of summary data entails some loss of precision due to rounding.

  4. POWERLIB: SAS/IML Software for Computing Power in Multivariate Linear Models

    Directory of Open Access Journals (Sweden)

    Jacqueline L. Johnson

    2009-04-01

    Full Text Available The POWERLIB SAS/IML software provides convenient power calculations for a widerange of multivariate linear models with Gaussian errors. The software includes the Box,Geisser-Greenhouse, Huynh-Feldt, and uncorrected tests in the univariate" approach torepeated measures (UNIREP, the Hotelling Lawley Trace, Pillai-Bartlett Trace, andWilks Lambda tests in multivariate" approach (MULTIREP, as well as a limited butuseful range of mixed models. The familiar univariate linear model with Gaussian errorsis an important special case. For estimated covariance, the software provides condencelimits for the resulting estimated power. All power and condence limits values canbe output to a SAS dataset, which can be used to easily produce plots and tables formanuscripts.

  5. PREFACE Proceedings of the XIV International Conference on Small-Angle Scattering, SAS-2009

    Science.gov (United States)

    King, Stephen; Terrill, Nicholas

    2010-10-01

    The XIV International Conference on Small-Angle Scattering, SAS-2009, was held in Oxford UK, 13-18 September 2009, and was jointly organised under the auspices of the International Union of Crystallography Commission on SAS by a team from the Diamond Light Source and the ISIS Pulsed Neutron Source - their first such joint venture - with help from the UK Science and Technology Facilities Council. It was the first time that this long running and successful series of conferences on the application, science and technology of small-angle scattering techniques had been staged in the UK. The UK has a proud heritage in small-angle scattering: as home to one of the world's first SANS instruments (at AERE Harwell), as the site of the world's first 2nd generation X-ray Synchrotron (the SRS at Daresbury with its suite of SAXS beamlines), and latterly as the location of the world's most successful pulsed source SANS instrument. Indeed, 2009 also marked the 25th Anniversary of neutron operations at ISIS and the opening of a Second Target Station. Whilst the SRS ceased operations in 2008, its mantle has been inherited by the Diamond synchrotron. Many delegates took the opportunity to visit both Diamond and ISIS during a conference excursion. Despite the prevailing global economic downturn, we were delighted that 434 delegates from 32 different countries were able to attend SAS-2009; two-thirds were drawn from the UK, Germany, Japan, the USA and France, but there were also sizeable contingents from Australia, Korea, Taiwan and South America. In many ways this geographical spread reflects the present and emerging distribution, respectively, of 3rd generation X-ray synchrotrons and high-flux neutron sources, although the scope of the conference was not solely limited to these probes. Financial support from the IUCr enabled us to grant bursaries to attend SAS-2009 to 12 delegates from emerging countries (Algeria, Argentina, Brazil, India, Nepal, Romania, Russia and the Ukraine). The

  6. SAS 2.0丰收期即将到来?

    Institute of Scientific and Technical Information of China (English)

    袁绍龙

    2009-01-01

    @@ SAS技术诞生8年以来经历了重重考验,现在SAS2.0走入产品化,也意味着苦熬多年的SAS技术即将迎来自己的丰收期. 2001年11月26号,Compaq、IBM、LSI、Maxtor和Seagate联合宣布成立SAS(Serial Attached SCSI,也称串行SCSI)工作组,标志着SAS正式走入存储的舞台.一晃近8年时间过去了,从刚开始的广泛质疑到现在的逐渐接受,SAS技术在这8年中经历了重重考验.

  7. SAS-2 observations of celestial diffuse gamma radiation above 30 MeV

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Kniffen, D. A.; Hartman, R. C.

    1974-01-01

    The small astronomy satellite, SAS-2, used a 32-deck magnetic core digitized spark chamber to study gamma rays with energies above 30 MeV. Data for four regions of the sky away from the galactic plane were analyzed. These regions show a finite, diffuse flux of gamma rays with a steep energy spectrum, and the flux is uniform over all the regions. Represented by a power law, the differential energy spectrum shows an index of 2.5 + or - 0.4. The steep SAS-2 spectrum and the lower energy data are reasonably consistent with a neutral pion gamma-ray spectrum which was red-shifted (such as that proposed by some cosmological theories). It is concluded that the diffuse celestial gamma ray spectrum observed presents the possibility of cosmological studies and possible evidence for a residual cosmic ray density, and supports the galactic superclusters of matter and antimatter remaining from baryon-symmetric big bang.

  8. The PLK4-STIL-SAS-6 module at the core of centriole duplication.

    Science.gov (United States)

    Arquint, Christian; Nigg, Erich A

    2016-10-15

    Centrioles are microtubule-based core components of centrosomes and cilia. They are duplicated exactly once during S-phase progression. Central to formation of each new (daughter) centriole is the formation of a nine-fold symmetrical cartwheel structure onto which microtubule triplets are deposited. In recent years, a module comprising the protein kinase polo-like kinase 4 (PLK4) and the two proteins STIL and SAS-6 have been shown to stay at the core of centriole duplication. Depletion of any one of these three proteins blocks centriole duplication and, conversely, overexpression causes centriole amplification. In this short review article, we summarize recent insights into how PLK4, STIL and SAS-6 co-operate in space and time to form a new centriole. These advances begin to shed light on the very first steps of centriole biogenesis.

  9. Síndrome de apnea del sueño (SAS Sleep apnea syndrome

    Directory of Open Access Journals (Sweden)

    Camilo José Borrego Abello

    1994-03-01

    Full Text Available Se describe el síndrome de apnea del sueño (SAS abarcando los aspectos históricos, signos y síntomas, las diversas modalidades (apneas obstructiva, central y mixta, complicaciones, principalmente cardiovasculares y cerebrovasculares y formas de tratamiento. Se hace énfasis en la ayuda diagnóstica del polisomnograma que ha permitido definir como SAS síntomas antes considerados inespecíficos y cuantificar su gravedad. Se describen las diversas medidas terapéuticas, locales y generales, recalcando los beneficios que se obtienen con la aplicación de los aparatos de respiración a presión positiva. Estos permiten tratamientos no invasivos que hacen desaparecer la totalidad de los síntomas y evitan los riesgos incrementados de trastornos cardiovasculares y accidentes laborales o de tránsito. Este grave síndrome afecta a un grupo grande de población por lo que su importancia es indudable.

    Different aspects of the sleep apnea síndrome (SAS are described, including history, clinical manifestations, clinical forms (obstructive, central and mixed, cardiovascular, cerebrovascular and other complications and treatment. With the use of the polysomnogram it has been possible to define non-specific symptoms as due to SAS and to quantitate their seriousness. Different therapeutic approaches are described, both local and systemic, with emphasis on the benefits obtained from the use of positive pressure breathing machines which control every manifestation of the syndrome and avoid the increased cardiovascular risks aswell as work and traffic accidents. This syndrome is important in terms of frequency and of increased death risk.

  10. Simple and flexible SAS and SPSS programs for analyzing lag-sequential categorical data.

    Science.gov (United States)

    O'Connor, B P

    1999-11-01

    This paper describes simple and flexible programs for analyzing lag-sequential categorical data, using SAS and SPSS. The programs read a stream of codes and produce a variety of lag-sequential statistics, including transitional frequencies, expected transitional frequencies, transitional probabilities, adjusted residuals, z values, Yule's Q values, likelihood ratio tests of stationarity across time and homogeneity across groups or segments, transformed kappas for unidirectional dependence, bidirectional dependence, parallel and nonparallel dominance, and significance levels based on both parametric and randomization tests.

  11. Immunomagnetic separation and visual fluorescence detection of Salmonella spp., using AOAC approved SAS Molecular Tests.

    Science.gov (United States)

    Bapanpally, Chandra; Maganty, Gayatri; Khan, Shah; Kasra, Akif; Morey, Amit

    2014-01-01

    The SAS Molecular Tests method for detection of Salmonella spp. in various food matrixes has been certified by the AOAC Research Institute and designated Performance Tested Method No. 021202. The current method modification includes the optional immunomagnetic separation (IMS) to enrich the bacteria as well as optional visual fluorescence readout without the use of a turbidimeter. The modifications were validated against the U.S. Department of Agriculture/ Food Safety and Inspection Service Microbiology Laboratory Guidebook (MLG) and the U.S. Food and Drug Administration Bacteriological Analytical Manual (BAM) reference methods. Food matrixes (chicken carcass rinse, beef trim, and spinach) were inoculated with low levels of Salmonella spp. (0.2-2 CFU/test portion) to generate fractional positives (5-15) in 20 inoculated samples. Samples were enriched with SAS Enrichment medium and incubated at 42 +/- 1 degree C. Enrichments were tested directly and subjected to anti-Salmonella IMS prior to the SAS Molecular Tests. Results were determined via visual fluorescence and via turbidity using a turbidimeter. All replicates were confirmed using the MLG or BAM reference method procedures, regardless of presumptive result. The SAS Molecular Tests Salmonella Detection modified methods were determined to be equivalent to the reference methods for the detection of Salmonella in chicken carcass rinse, beef trim, and fresh spinach. The inclusion of IMS in the modified method improved the detection rate of Salmonella in chicken carcass rinses and spinach. The optional use of visual fluorescent reagent and heat block either with IMS or without IMS produced results that were comparable to the results obtained from using a real-time turbidimeter.

  12. Learning SAS’s Perl Regular Expression Matching the Easy Way: By Doing

    Science.gov (United States)

    2015-01-12

    Regular Expression ( PRX ) functions were added in SAS9. The key to learning how to use them is learning PRX metacharacter behavior within a PRX match. The...more you practice PRX matching, the more proficient you become. Ideally, practice would involve a method for repeating the matching process so as to...regex_learning_tool allows both beginner and expert to efficiently practice PRX matching by selecting and processing only the match records that the user is interested

  13. Poisson回归模型的SAS GENMOD实现方法

    Institute of Scientific and Technical Information of China (English)

    孟小平

    2000-01-01

    通过实例演示了Poisson回归模型的SAS程序实现方法,采用SAS GENMOD过程进行Poisson回归分析,结果齐全、应用灵活,为服从Poisson分布的队列、随访等频数资料提供了有力的分析工具.

  14. Recent results of X-ray observations from OSO-7 and SAS-3

    Science.gov (United States)

    Clark, G. W.

    1978-01-01

    Recent observations bearing on the nature of compact X-ray sources obtained from the MIT instruments aboard OSO-7 and SAS-3 are discussed. Results on the X-ray sky survey, new ultralow-energy X-ray sources, X-ray sources in globular clusters, slow X-ray pulsars, and variability and position of compact X-ray sources in Cen A are discussed. Descriptions of the satellite-borne X-ray instruments are provided.

  15. SAS-3 observations of an X-ray flare from Cygnus X-1

    Science.gov (United States)

    Canizares, C. R.; Bradt, H.; Buff, J.; Laufer, B.

    1976-01-01

    Preliminary results are presented for the SAS-3 observation of an X-ray flare from Cygnus X-1. The 1.5 to 6 keV intensity rose by a factor of four and exhibited variability on several time scales from seconds to hours. The 6 to 15 keV intensity showed less activity. The event is similar to that observed by ANS and Ariel 5, but lasted less than two weeks.

  16. SAS统计分析软件模块揽要%Profiles on Modules of SAS

    Institute of Scientific and Technical Information of China (English)

    黄伟; 黄瑜

    2008-01-01

    SAS(Statistics Analysis System)是20世纪60年代初美国SAS公司研发的统计分析软件.SAS与SPSS及BMDP并称为国际上最有知名度的三大统计软件,如今,在我国社会科学乃至自然科学领域已得到了广泛应用.

  17. The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition.

    Science.gov (United States)

    Yamamoto, Masatoshi; Ohsawa, Shizue; Kunimasa, Kei; Igaki, Tatsushi

    2017-02-09

    Normal epithelial cells often exert anti-tumour effects against nearby oncogenic cells. In the Drosophila imaginal epithelium, clones of oncogenic cells with loss-of-function mutations in the apico-basal polarity genes scribble or discs large are actively eliminated by cell competition when surrounded by wild-type cells. Although c-Jun N-terminal kinase (JNK) signalling plays a crucial role in this cell elimination, the initial event, which occurs at the interface between normal cells and polarity-deficient cells, has not previously been identified. Here, through a genetic screen in Drosophila, we identify the ligand Sas and the receptor-type tyrosine phosphatase PTP10D as the cell-surface ligand-receptor system that drives tumour-suppressive cell competition. At the interface between the wild-type 'winner' and the polarity-deficient 'loser' clones, winner cells relocalize Sas to the lateral cell surface, whereas loser cells relocalize PTP10D there. This leads to the trans-activation of Sas-PTP10D signalling in loser cells, which restrains EGFR signalling and thereby enables elevated JNK signalling in loser cells, triggering cell elimination. In the absence of Sas-PTP10D, elevated EGFR signalling in loser cells switches the role of JNK from pro-apoptotic to pro-proliferative by inactivating the Hippo pathway, thereby driving the overgrowth of polarity-deficient cells. These findings uncover the mechanism by which normal epithelial cells recognize oncogenic polarity-deficient neighbours to drive cell competition.

  18. Solubilization of the poorly water soluble drug, telmisartan, using supercritical anti-solvent (SAS) process.

    Science.gov (United States)

    Park, Junsung; Cho, Wonkyung; Cha, Kwang-Ho; Ahn, Junhyun; Han, Kang; Hwang, Sung-Joo

    2013-01-30

    Telmisartan is a biopharmaceutical classification system (BCS) class II drug that has extremely low water solubility but is freely soluble in highly alkalized solutions. Few organic solvents can dissolve telmisartan. This solubility problem is the main obstacle achieving the desired bioavailability. Because of its unique characteristics, the supercritical anti-solvent (SAS) process was used to BCS class II drug in a variety of ways including micronization, amorphization and solid dispersion. Solid dispersions were prepared using hydroxypropylmethylcellulose/polyvinylpyrrolidone (HPMC/PVP) at 1:0.5, 1:1, and 1:2 weight ratios of drug to polymer, and pure telmisartan was also treated using the SAS process. Processed samples were characterized for morphology, particle size, crystallinity, solubility, dissolution rate and polymorphic stability. After the SAS process, all samples were converted to the amorphous form and were confirmed to be hundreds nm in size. Solubility and dissolution rate were increased compared to the raw material. Solubility tended to increase with increases in the amount of polymer used. However, unlike the solubility results, the dissolution rate decreased with increases in polymer concentration due to gel layer formation of the polymer. Processed pure telmisartan showed the best drug release even though it had lower solubility compared to other solid dispersions; however, because there were no stabilizers in processed pure telmisartan, it recrystallized after 1 month under severe conditions, while the other solid dispersion samples remained amorphous form. We conclude that after controlling the formulation of solid dispersion, the SAS process could be a promising approach for improving the solubility and dissolution rate of telmisartan.

  19. Cosmic radiation and airline pilots. Exposure patterns of Norwegian SAS-pilots 1960 to 1994

    Energy Technology Data Exchange (ETDEWEB)

    Tveten, U.

    1997-02-01

    The work which is presented in this report is part of a Norwegian epidemiological project, carried out in cooperation between Institutt for Energiteknikk (IFE), the Norwegian Cancer Registry (NCR) and the Norwegian Radiation Protection Authority (NRPA). The project has been partially financed by the Norwegian Research Council. Originating from the Norwegian project, a number of similar projects have been started or are in the planning stage in a number of European countries. The present report lays the ground for estimation of individual exposure histories to cosmic radiation of pilots employed by the Scandinavian Airline System (SAS). The results presented in this report (radiation doserates for the different types of aircraft in the different years) will, in a later stage of the project, be utilized to estimate the individual radiation exposure histories. The major sources of information used as basis for this work is the collection of old SAS time tables found in the SAS Museum at Fornebu Airport in Oslo, and information provided by members of the Pilots Associations.

  20. Adaptation and Validation of the Sexual Assertiveness Scale (SAS) in a Sample of Male Drug Users.

    Science.gov (United States)

    Vallejo-Medina, Pablo; Sierra, Juan Carlos

    2015-04-21

    The aim of the present study was to adapt and validate the Sexual Assertiveness Scale (SAS) in a sample of male drug users. A sample of 326 male drug users and 322 non-clinical males was selected by cluster sampling and convenience sampling, respectively. Results showed that the scale had good psychometric properties and adequate internal consistency reliability (Initiation = .66, Refusal = .74 and STD-P = .79). An evaluation of the invariance showed strong factor equivalence between both samples. A high and moderate effect of Differential Item Functioning was only found in items 1 and 14 (∆R 2 Nagelkerke = .076 and .037, respectively). We strongly recommend not using item 1 if the goal is to compare the scores of both groups, otherwise the comparison will be biased. Correlations obtained between the CSFQ-14 and the safe sex ratio and the SAS subscales were significant (CI = 95%) and indicated good concurrent validity. Scores of male drug users were similar to those of non-clinical males. Therefore, the adaptation of the SAS to drug users provides enough guarantees for reliable and valid use in both clinical practice and research, although care should be taken with item 1.

  1. Living Together v. Living Well Together: A Normative Examination of the SAS Case

    Directory of Open Access Journals (Sweden)

    Lori G. Beaman

    2016-04-01

    Full Text Available The European Court of Human Rights decision in SAS from France illustrates how a policy and national mantra that ostensibly aims to enhance inclusiveness, ‘living together’, is legally deployed in a manner that may have the opposite effect. In essence, despite acknowledging the sincerity of SAS’s religious practice of wearing the niqab, and her agency in making the decision to do so, the Court focuses on radicalism and women’s oppression amongst Muslims. Taking the notion of living together as the beginning point, the paper explores the normative assumptions underlying this notion as illustrated in the judgment of the Court. An alternative approach, drawing on the work of Derrida for the notion of ‘living well together’ will be proposed and its implications for social inclusion explicated. The paper’s aim is to move beyond the specific example of SAS and France to argue that the SAS pattern of identifying particular values as ‘national values’, the deployment of those values through law, policy and public discourse, and their exclusionary effects is playing out in a number of Western democracies, including Canada, the country with which the author is most familiar. Because of this widespread dissemination of values and their framing as representative of who ‘we’ are, there is a pressing need to consider the potentially alienating effects of a specific manifestation of ‘living together’ and an alternative model of ‘living well together’.

  2. Embedding SAS approach into conjugate gradient algorithms for asymmetric 3D elasticity problems

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Hsin-Chu; Warsi, N.A. [Clark Atlanta Univ., GA (United States); Sameh, A. [Univ. of Minnesota, Minneapolis, MN (United States)

    1996-12-31

    In this paper, we present two strategies to embed the SAS (symmetric-and-antisymmetric) scheme into conjugate gradient (CG) algorithms to make solving 3D elasticity problems, with or without global reflexive symmetry, more efficient. The SAS approach is physically a domain decomposition scheme that takes advantage of reflexive symmetry of discretized physical problems, and algebraically a matrix transformation method that exploits special reflexivity properties of the matrix resulting from discretization. In addition to offering large-grain parallelism, which is valuable in a multiprocessing environment, the SAS scheme also has the potential for reducing arithmetic operations in the numerical solution of a reasonably wide class of scientific and engineering problems. This approach can be applied directly to problems that have global reflexive symmetry, yielding smaller and independent subproblems to solve, or indirectly to problems with partial symmetry, resulting in loosely coupled subproblems. The decomposition is achieved by separating the reflexive subspace from the antireflexive one, possessed by a special class of matrices A, A {element_of} C{sup n x n} that satisfy the relation A = PAP where P is a reflection matrix (symmetric signed permutation matrix).

  3. [Perioperative management in children with sleep apnea syndrome (SAS) undergoing adenoidotonsillectomy].

    Science.gov (United States)

    Mizuno, Ju; Nemoto, Mikiko; Sato, Tomoko; Yokoyama, Takeshi; Hanaoka, Kazuo

    2013-02-01

    We should take care of the occurrences of apnea and hypopnea after emergence from general anesthesia in the children with sleep apnea syndrome (SAS) due to an increase in sensitivity to opioid agonists given for previous recurrent hypoxia. Preoperative assessment for SAS with apnea hypopnea index (AHI), oxygen desaturation index (ODI), and minimum artery oxygen saturation by pulse oxymetry (lowest SpO2) obtained from polysomnography (PSG) test could help to predict the postoperative respiratory depression. In perioperative management in the children with SAS who are candidates for adenotonsillectomy, the dose of opioid agonists during anesthesia maintenance for purpose of postoperative analgesia and sedation should be reduced; postoperative respiratory and circulatory management with monitoring of respiratory movement of the thoracoabdominal part, and electrographic (ECG) and SpO2 monitoring should be continued intensively under long-term oxygen administration; and airway management, nasal continuous positive airway pressure (nCPAP), and artificial ventilation should be prepared for the occurrence of postoperative respiratory depression.

  4. [Perioperative management of an obese patient complicated with sleep apnea syndrome (SAS) undergoing awake craniotomy].

    Science.gov (United States)

    Komayama, Noriaki; Kamata, Kotoe; Maruyama, Takashi; Nitta, Masayuki; Muragaki, Yoshihiro; Ozaki, Makoto

    2014-10-01

    Both obesity (BMI over 30) and SAS are risks for Supper airway maintenance. We report an obese patient (BMI 33.5) with SAS who underwent awake craniotomy. Weight reduction was instructed 1 month before the operation, and the patient lost enough weight to use intraoperative MRI. Under general anesthesia, surgical pads containing 2% lidocaine with adrenaline were inserted into the nasal cavities. The patient's airway S was secured by i-gel® until dura was opened. A nasal airway was then inserted to confirm the upper airway patency and anesthetics were terminated The patient regained consciousness and started respiration. The i-gel® was removed. The nasal airway was changed to an RAE tracheal tube ; the tube was fixed above the vocal cords under bronchofiberscopic observation. Continuous positive airway pressure (CPAP) via RAE tube was started. Neither coughing nor epistaxis was observed.The RAE tube prevented glossoptosis and did not disturb speech mapping. Emergent endotracheal intubation was easily managed because the tube was close to the glottis. The RAE tube was removed and nasal CP AP was applied overnight Carefully prepared CP AP support via nasal RAE tube was practical in keeping upper airway patency for an obese patient complicated with SAS undergoing awake craniotomy.

  5. 基于SAS-WEBLOGIC的数据挖掘模型及应用%Data mining model and application based on SAS-weblogic

    Institute of Scientific and Technical Information of China (English)

    宋丽红

    2009-01-01

    提出了一种基于SAS-Weblogic的数据挖掘模型,SAS作为数据挖掘语言处于模型的核心,Weblogic作为中间构件,负责SAS数据集联系前端浏览器和后台数据库,起着监控和管理作用.该模型适用于大中型数据挖掘应用,为现代企业提供了一种重要的决策支持系统模型.最后通过实验证明了模型的有效性.

  6. Aprenentatge cooperatiu interdisciplinari i rúbriques per a la millora del procés d'ensenyament-aprenentatge

    Directory of Open Access Journals (Sweden)

    Beatriz Corchuelo Martínez-Azúa

    2016-06-01

    Full Text Available L'adaptació dels títols a l'Espai Europeu d'Educació Superior (EEES suposa l'ocasió de millorar l'educació integral dels alumnes, orientant les accions docents cap al desenvolupament de competències. L'adquisició de competències exigeix la incorporació de metodologies docents actives que permetin la generació enfront de la mera transmissió de coneixements. Així mateix, nombrosos estudis adverteixen de l'escassa transferència existent en els coneixements tractats en les assignatures quan es consideren de manera individual. El treball interdisciplinari constitueix una valuosa eina perquè els estudiants facin connexions, plantegin i trobin respostes a situacions problemàtiques i ajustin el seu aprenentatge a un coneixement integral. Pel que s'ha vist la necessitat de desenvolupar, en el currículum formatiu de l'alumne, aproximacions interdisciplinàries.Tenint en compte aquests aspectes, s'ha realitzat una experiència d'innovació docent universitària de caràcter interdisciplinari en la qual s'integren els continguts i competències de diverses assignatures per abordar el procés de solució de problemes econòmics. S'ha treballat la interdisciplinaritat amb tècniques d'aprenentatge cooperatiu. La interacció d’aquests aspectes és la raó por la quual hem denominat a l'experiència “Aprenentatge Cooperatiu Interdisciplinari” (ACI. L'avaluació de l'aprenentatge es realitza de forma individual, (mitjançant heteroevaluació i coevaluació, i grupal, (mitjançant rúbriques i coevaluació.Els resultats mostren diversos aspectes: 1 La metodologia ACI no solament permet formar en continguts sinó també en competències. 2 La interconnexió entre assignatures ha permès que els alumnes ajuste n els seus aprenentatges cap a un coneixement més integral. 3 La unió de les diferents innovacions docents ha repercutit positivament en la motivació de l'alumnat. 4 S'han assolit resultats d'aprenentatge positius en l'alumnat, majors

  7. Les procès contre le sanctuaire Yasukuni The trials of WW2 veterans’ families against the Yasukuni shrine

    Directory of Open Access Journals (Sweden)

    Nobumasa Tanaka

    2010-07-01

    Full Text Available Le sanctuaire Yasukuni a été fondé à Tôkyô en 1869 par l’empereur Meiji pour célébrer la mémoire des guerriers japonais tombés au combat pour l’empereur et la patrie. Etablissement religieux chargé d’honorer les hauts faits de ces « âmes héroïques », il fut longtemps le symbole du militarisme japonais. Or, parmi les familles qui ont perdu l’un des leurs au cours de la guerre d’agression menée par le Japon en Asie, certaines ont engagé des poursuites contre l’administration du Yasukuni, afin d’obtenir que les noms de leurs proches soient radiés des listes du sanctuaire. Cet article retrace l’historique des procès engagés par ces familles, en examinant au passage les plaintes déposées contre le caractère anticonstitutionnel des visites répétées du Premier ministre Koizumi au Yasukuni.The Yasukuni shrine was founded in Tokyo in 1868 by the Emperor Meiji to celebrate the memory of Japanese warriors fallen during battles for the Emperor and the country. As religious institution devoted to honor these “brave souls”, it became the symbol of Japanese militarism. However, among the families who lost relatives during the war, some have sued the administration of Yasukuni to get the names of their relatives deleted from the lists of the shrine. This article describes the genesis of those trials and exams also the anti-constitutional nature of the repeated visits of Prime Minister Koizumi to Yasukuni.

  8. Mesures de procédure spéciales et respect des droits de l'homme Rapport général

    Directory of Open Access Journals (Sweden)

    John A.E. Vervaele

    2009-10-01

    Full Text Available Le but du rapport général est de mener une analyse comparative des rapports nationaux en vue de présenter les processus de transformation des systèmes de justice pénale internes, en particulier du procès pénal, étant donné que des mesures procédurales spéciales sont introduites pour appréhender le terrorisme et la criminalité organisée, et de voir si cela a conduit les pays à se départir de leur propres règles fondamentales, procédures, principes et standards des droits de l’homme applicables. Partant de la prémisse qu’un système intégré de droit pénal a trois dimensions – la protection des individus (la dimension de bouclier, la mise à disposition d’instruments d’application de la loi (la dimension d’épée et les contrôles et équilibres c’est-à-dire la séparation des pouvoirs (la dimension constitutionnelle – le rapport fournit un aperçu d’ensemble des transformations corrélées, surtout dans la procédure d’enquête préliminaire, qui les ont affectées toutes les trois dans trois vagues de « guerre » (contre la drogue, le crime organisé et le terrorisme. Dans beaucoup de pays, les garanties procédurales et les principes qui protègent contre la violation du droit à un procès équitable sont considérés comme un fardeau du point de vue de l’efficacité de l’application de la loi à la criminalité grave. Ces réformes se sont traduites par une claire extension de l’état répressif et un estompement des distinctions classiques, et ne favorisent pas la primauté du droit. La focalisation sur la sécurité publique et les investigations contraignantes préventives sapent le système de justice pénale. Avec l’usage croissant du système de justice criminelle comme instrument de régulation du présent et/ou de l’avenir plutôt que de sanction d’un comportement passé, et un procès pénal dans lequel l’enquête préliminaire ne concerne pas la recherche de la v

  9. Jacqueline Hoareau-Dodinau, Guillaume Metairie, Pascal Texier. Procéder. Pas d’action, pas de droit ou pas de droit, pas d’action ?

    Directory of Open Access Journals (Sweden)

    Robert Pageard

    2009-05-01

    Full Text Available Cet ensemble de vingt-cinq textes est le produit d’une collaboration entre l’Institut d’Anthropologie Juridique de Limoges et l’Association Française Droit et Cultures, éditrice de la présente revue, en union avec le Centre Droit et Cultures de l’Université de Paris X-Nanterre.Les vingt-quatre contributions sont suivies d’une vue globale de Guillaume Métairie : « Procéder… à la synthèse ».De manière générale, la procédure peut être définie comme une démarche obligatoire et ordonnée tendant à ...

  10. Usual Dietary Intakes: SAS Macros for Estimating Ratios of Two Dietary Components that are Consumed Nearly Every Day

    Science.gov (United States)

    The following SAS macros can be used to create a bivariate distribution of usual intake of two dietary components that are consumed nearly every day and to calculate percentiles of the population distribution of the ratio of usual intakes.

  11. Repositioning the substrate activity screening (SAS) approach as a fragment-based method for identification of weak binders.

    Science.gov (United States)

    Gladysz, Rafaela; Cleenewerck, Matthias; Joossens, Jurgen; Lambeir, Anne-Marie; Augustyns, Koen; Van der Veken, Pieter

    2014-10-13

    Fragment-based drug discovery (FBDD) has evolved into an established approach for "hit" identification. Typically, most applications of FBDD depend on specialised cost- and time-intensive biophysical techniques. The substrate activity screening (SAS) approach has been proposed as a relatively cheap and straightforward alternative for identification of fragments for enzyme inhibitors. We have investigated SAS for the discovery of inhibitors of oncology target urokinase (uPA). Although our results support the key hypotheses of SAS, we also encountered a number of unreported limitations. In response, we propose an efficient modified methodology: "MSAS" (modified substrate activity screening). MSAS circumvents the limitations of SAS and broadens its scope by providing additional fragments and more coherent SAR data. As well as presenting and validating MSAS, this study expands existing SAR knowledge for the S1 pocket of uPA and reports new reversible and irreversible uPA inhibitor scaffolds.

  12. De novo centriole formation in human cells is error-prone and does not require SAS-6 self-assembly.

    Science.gov (United States)

    Wang, Won-Jing; Acehan, Devrim; Kao, Chien-Han; Jane, Wann-Neng; Uryu, Kunihiro; Tsou, Meng-Fu Bryan

    2015-11-26

    Vertebrate centrioles normally propagate through duplication, but in the absence of preexisting centrioles, de novo synthesis can occur. Consistently, centriole formation is thought to strictly rely on self-assembly, involving self-oligomerization of the centriolar protein SAS-6. Here, through reconstitution of de novo synthesis in human cells, we surprisingly found that normal looking centrioles capable of duplication and ciliation can arise in the absence of SAS-6 self-oligomerization. Moreover, whereas canonically duplicated centrioles always form correctly, de novo centrioles are prone to structural errors, even in the presence of SAS-6 self-oligomerization. These results indicate that centriole biogenesis does not strictly depend on SAS-6 self-assembly, and may require preexisting centrioles to ensure structural accuracy, fundamentally deviating from the current paradigm.

  13. Validation of SCALE (SAS2H) Isotopic Predictions for BWR Spent Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Hermann, O.W.

    1998-01-01

    Thirty spent fuel samples obtained from boiling-water-reactor (BWR) fuel pins have been modeled at Oak Ridge National Laboratory using the SAS2H sequence of the SCALE code system. The SAS2H sequence uses transport methods combined with the depletion and decay capabilities of the ORIGEN-S code to estimate the isotopic composition of fuel as a function of its burnup history. Results of these calculations are compared with chemical assay measurements of spent fuel inventories for each sample. Results show reasonable agreement between measured and predicted isotopic concentrations for important actinides; however, little data are available for most fission products considered to be important for spent fuel concerns (e.g., burnup credit, shielding, source-term calculations, etc.). This work is a follow-up to earlier works that studied the ability to predict spent fuel compositions in pressurized-water-reactor (PWR) fuel pins. Biases and uncertainties associated with BWR isotopic predictions are found to be larger than those of PWR calculations. Such behavior is expected, as the operation of a BWR is significantly more complex than that of a PWR plant, and in general the design of a BWR has a more heterogeneous configuration than that of a PWR. Nevertheless, this work shows that the simple models employed using SAS2H to represent such complexities result in agreement to within 5% (and often less than 1%) or less for most nuclides important for spent fuel applications. On the other hand, however, the set of fuel samples analyzed represent a small subset of the BWR fuel population, and results reported herein may not be representative of the full population of BWR spent fuel.

  14. Validation of SCALE (SAS2H) isotopic predictions for BWR spent fuel

    Energy Technology Data Exchange (ETDEWEB)

    Hermann, O.W.; DeHart, M.D.

    1998-09-01

    Thirty spent fuel samples obtained from boiling-water-reactor (BWR) fuel pins have been modeled at Oak Ridge National Laboratory using the SAS2H sequence of the SCALE code system. The SAS2H sequence uses transport methods combined with the depletion and decay capabilities of the ORIGEN-S code to estimate the isotopic composition of fuel as a function of its burnup history. Results of these calculations are compared with chemical assay measurements of spent fuel inventories for each sample. Results show reasonable agreement between measured and predicted isotopic concentrations for important actinides; however, little data are available for most fission products considered to be important for spent fuel concerns (e.g., burnup credit, shielding, source-term calculations, etc.). This work is a follow-up to earlier works that studied the ability to predict spent fuel compositions in pressurized-water-reactor (PWR) fuel pins. Biases and uncertainties associated with BWR isotopic predictions are found to be larger than those of PWR calculations. Such behavior is expected, as the operation of a BWR is significantly more complex than that of a PWR plant, and in general the design of a BWR has a more heterogeneous configuration than that of a PWR. Nevertheless, this work shows that the simple models employed using SAS2H to represent such complexities result in agreement to within 5% (and often less than 1%) or less for most nuclides important for spent fuel applications. On the other hand, however, the set of fuel samples analyzed represent a small subset of the BWR fuel population, and results reported herein may not be representative of the full population of BWR spent fuel.

  15. Handling missing data in cluster randomized trials: A demonstration of multiple imputation with PAN through SAS

    Directory of Open Access Journals (Sweden)

    Jiangxiu Zhou

    2014-09-01

    Full Text Available The purpose of this study is to demonstrate a way of dealing with missing data in clustered randomized trials by doing multiple imputation (MI with the PAN package in R through SAS. The procedure for doing MI with PAN through SAS is demonstrated in detail in order for researchers to be able to use this procedure with their own data. An illustration of the technique with empirical data was also included. In this illustration thePAN results were compared with pairwise deletion and three types of MI: (1 Normal Model (NM-MI ignoring the cluster structure; (2 NM-MI with dummy-coded cluster variables (fixed cluster structure; and (3 a hybrid NM-MI which imputes half the time ignoring the cluster structure, and the other half including the dummy-coded cluster variables. The empirical analysis showed that using PAN and the other strategies produced comparable parameter estimates. However, the dummy-coded MI overestimated the intraclass correlation, whereas MI ignoring the cluster structure and the hybrid MI underestimated the intraclass correlation. When compared with PAN, the p-value and standard error for the treatment effect were higher with dummy-coded MI, and lower with MI ignoring the clusterstructure, the hybrid MI approach, and pairwise deletion. Previous studies have shown that NM-MI is not appropriate for handling missing data in clustered randomized trials. This approach, in addition to the pairwise deletion approach, leads to a biased intraclass correlation and faultystatistical conclusions. Imputation in clustered randomized trials should be performed with PAN. We have demonstrated an easy way for using PAN through SAS.

  16. SAS molecular tests Escherichia coli O157 detection kit. Performance tested method 031203.

    Science.gov (United States)

    Bapanpally, Chandra; Montier, Laura; Khan, Shah; Kasra, Akif; Brunelle, Sharon L

    2014-01-01

    The SAS Molecular tests Escherichia coli O157 Detection method, a loop-mediated isothermal amplification method, performed as well as or better than the U.S. Department of Agriculture, Food Safety Inspection Service Microbiology Laboratory Guidebook and the U.S. Food and Drug Administration Bacteriological Analytical Manual reference methods for ground beef, beef trim, bagged mixed lettuce, and fresh spinach. Ground beef (30% fat, 25 g test portion) was validated for 7-8 h enrichment, leafy greens were validated in a 6-7 h enrichment, and ground beef (30% fat, 375 g composite test portion) and beef trim (375 g composite test portion) were validated in a 16-20 h enrichment. The method performance for meat and leafy green matrixes was also shown to be acceptable under conditions of co-enrichment with Salmonella. Thus, after a short co-enrichment step, ground beef, beef trim, lettuce, and spinach can be tested for both Salmonella and E. coli O157. The SAS Molecular tests Salmonella Detection Kit was validated using the same test portions as for the SAS Molecular tests E. coli O157 Detection Kit and those results are presented in a separate report. Inclusivity and exclusivity testing revealed no false negatives and no false positives among the 50 E. coli 0157 strains, including H7 and non-motile strains, and 30 non-E. coli O157 strains examined. Finally, the method was shown to be robust when variations to DNA extract hold time and DNA volume were varied. The method comparison and robustness data suggest a full 7 h enrichment time should be used for 25 g ground beef test portions.

  17. Human SAS-6 C-Terminus Nucleates and Promotes Microtubule Assembly in Vitro by Binding to Microtubules.

    Science.gov (United States)

    Gupta, Hindol; Badarudeen, Binshad; George, Athira; Thomas, Geethu Emily; Gireesh, K K; Manna, Tapas K

    2015-10-20

    Centrioles are essential components of the animal centrosome and play crucial roles in the formation of cilia and flagella. They are cylindrical structures composed of nine triplet microtubules organized around a central cartwheel. Recent studies have identified spindle assembly abnormal protein SAS-6 as a critical component necessary for formation of the cartwheel. However, the molecular details of how the cartwheel participates in centriolar microtubule assembly have not been clearly understood. In this report, we show that the C-terminal tail (residues 470-657) of human SAS-6, HsSAS-6 C, the region that has been shown to extend toward the centriolar wall where the microtubule triplets are organized, nucleated and induced microtubule polymerization in vitro. The N-terminus (residues 1-166) of HsSAS-6, the domain known to be involved in formation of the central hub of the cartwheel, did not, however, exert any effect on microtubule polymerization. HsSAS-6 C bound to the microtubules and localized along the lengths of the microtubules in vitro. Microtubule pull-down and coimmunoprecipitation (Co-IP) experiments with S-phase synchronized HeLa cell lysates showed that the endogenous HsSAS-6 coprecipitated with the microtubules, and it mediated interaction with tubulin. Isothermal calorimetry titration and size exclusion chromatography showed that HsSAS-6 C bound to the αβ-tubulin dimer in vitro. The results demonstrate that HsSAS-6 possesses an intrinsic microtubule assembly promoting activity and further implicate that its outer exposed C-terminal tail may play critical roles in microtubule assembly and stabilizing microtubule attachment with the centriolar cartwheel.

  18. Modelo de franquicia "Wico y Dass Pasteleritos S.A.S"

    OpenAIRE

    2013-01-01

    El modelo de franquicia para la empresa Wico Y Dass Pasteleritos S.A.S. se realizó con base a la investigación en torno al modelo de desarrollo de las franquicias tanto a nivel nacional como internacional, evidenciando en los grandes logros que han obtenido algunas empresas internacionales al aplicar el modelo franquiciario. En Colombia, los tipos de negociación basados en franquicias aún no se encuentran reglamentados por la jurisprudencia colombiana, por lo tanto, fue necesario guia...

  19. Café de la Montaña S.A.S

    OpenAIRE

    2013-01-01

    Crear la empresa Café de la Montaña S.A.S, para la implementación y sostenimiento de 27.500 árboles de café variedad castillo y producir 27.500 Kg de café pergamino seco de alta calidad en la finca La Estrella, vereda Buena Vista, municipio de Campo alegre departamento del Huila. El concepto innovador en este proyecto se encuentra en la implementación de un sistema agroforestal asociado al cultivo de café, además la implementación del modelo becolsub como alternativa para descontaminar los su...

  20. Adaptive Tests of Significance Using Permutations of Residuals with R and SAS

    CERN Document Server

    O'Gorman, Thomas W

    2012-01-01

    Provides the tools needed to successfully perform adaptive tests across a broad range of datasets Adaptive Tests of Significance Using Permutations of Residuals with R and SAS illustrates the power of adaptive tests and showcases their ability to adjust the testing method to suit a particular set of data. The book utilizes state-of-the-art software to demonstrate the practicality and benefits for data analysis in various fields of study. Beginning with an introduction, the book moves on to explore the underlying concepts of adaptive tests, including:Smoothing methods and normalizing transforma

  1. Generation of Synthetic SAS Data for Targets near the Seafloor: Propagation Component

    Science.gov (United States)

    2012-09-30

    ωωϕθω ωω srcijij it imin ti tj jmjn ti ij PFrr BAe rr BAeP ij       −        − =  , (1) where Psrc(ω) is the frequency... application and consists of the source and receiver locations rs and rr and a single image source located at rsi and image receiver at rri. This...range (provide the range meets the far field requirement). IMPACT/ APPLICATIONS The current version of SAS-ST has been used in comparisons with data

  2. %lrasch_mml: A SAS Macro for Marginal Maximum Likelihood Estimation in Longitudinal Polytomous Rasch Models

    Directory of Open Access Journals (Sweden)

    Maja Olsbjerg

    2015-10-01

    Full Text Available Item response theory models are often applied when a number items are used to measure a unidimensional latent variable. Originally proposed and used within educational research, they are also used when focus is on physical functioning or psychological wellbeing. Modern applications often need more general models, typically models for multidimensional latent variables or longitudinal models for repeated measurements. This paper describes a SAS macro that fits two-dimensional polytomous Rasch models using a specification of the model that is sufficiently flexible to accommodate longitudinal Rasch models. The macro estimates item parameters using marginal maximum likelihood estimation. A graphical presentation of item characteristic curves is included.

  3. %lrasch_mml: A SAS Macro for Marginal Maximum Likelihood Estimation in Longitudinal Polytomous Rasch Models

    Directory of Open Access Journals (Sweden)

    Maja Olsbjerg

    2015-10-01

    Full Text Available Item response theory models are often applied when a number items are used to measure a unidimensional latent variable. Originally proposed and used within educational research, they are also used when focus is on physical functioning or psychological wellbeing. Modern applications often need more general models, typically models for multidimensional latent variables or longitudinal models for repeated measurements. This paper describes a SAS macro that fits two-dimensional polytomous Rasch models using a specification of the model that is sufficiently flexible to accommodate longitudinal Rasch models. The macro estimates item parameters using marginal maximum likelihood estimation. A graphical presentation of item characteristic curves is included.

  4. SAS-2 observations of high energy gamma rays from discrete sources

    Science.gov (United States)

    Kniffen, D. A.; Fichtel, C. E.; Hartman, R. C.; Lamb, R. C.; Thompson, D. J.

    1977-01-01

    The SAS-2 identified six localized high energy (greater than 35 MeV) gamma ray sources. Four of these are the radio pulsars, PSR 0531+21, PSR 0833-45, PSR 1818-04, and PSR 1717-46 discovered in a search of 75 radio pulsars. The fact that only one of these is observed in X-rays, and the significant differences in pulse profiles in the gamma ray and radio observations, leads to the speculation that different mechanisms are involved.

  5. Gypenosides causes DNA damage and inhibits expression of DNA repair genes of human oral cancer SAS cells.

    Science.gov (United States)

    Lu, Kung-Wen; Chen, Jung-Chou; Lai, Tung-Yuan; Yang, Jai-Sing; Weng, Shu-Wen; Ma, Yi-Shih; Tang, Nou-Ying; Lu, Pei-Jung; Weng, Jing-Ru; Chung, Jing-Gung

    2010-01-01

    Gypenosides (Gyp) are the major components of Gynostemma pentaphyllum Makino, a Chinese medical plant. Recently, Gyp has been shown to induce cell cycle arrest and apoptosis in many human cancer cell lines. However, there is no available information to address the effects of Gyp on DNA damage and DNA repair-associated gene expression in human oral cancer cells. Therefore, we investigated whether Gyp induced DNA damage and DNA repair gene expression in human oral cancer SAS cells. The results from flow cytometric assay indicated that Gyp-induced cytotoxic effects led to a decrease in the percentage of viable SAS cells. The results from comet assay revealed that the incubation of SAS cells with Gyp led to a longer DNA migration smear (comet tail) when compared with control and this effect was dose-dependent. The results from real-time PCR analysis indicated that treatment of SAS cells with 180 mug/ml of Gyp for 24 h led to a decrease in 14-3-3sigma, DNA-dependent serine/threonine protein kinase (DNAPK), p53, ataxia telangiectasia mutated (ATM), ataxia-telangiectasia and Rad3-related (ATR) and breast cancer gene 1 (BRCA1) mRNA expression. These observations may explain the cell death caused by Gyp in SAS cells. Taken together, Gyp induced DNA damage and inhibited DNA repair-associated gene expressions in human oral cancer SAS cells in vitro.

  6. Detection of sasX gene in Staphylococcus aureus and molecular epidemiological characteristics%金黄色葡萄球菌sasX基因的检测及其分子流行特征

    Institute of Scientific and Technical Information of China (English)

    钟一鸣; 丁健生; 刘文恩; 李虹玲; 晏群; 刘清霞

    2016-01-01

    目的:调查医院金黄色葡萄球菌 sasX 基因的携带情况并探究其分子流行特征,为揭示该基因在本地区的流行状况提供依据。方法收集中南大学湘雅医院2012年1-12月临床分离鉴定的金黄色葡萄球菌128株,采用 PCR 检测 sasX 基因,对该基因阳性的菌株采用多重 PCR 检测 SCCmec 分型、PCR 扩增 pvl 毒素基因,并进行多位点序列分型(MLST )和葡萄球菌 A 蛋白序列分析。结果128株金黄色葡萄球菌中共检测出2株 sasX 基因阳性菌株,检出率为1.6%,经头孢西丁鉴定这2株菌株均为耐甲氧西林金黄色葡萄球菌(MRSA),SCCmec Ⅲ分型均为 SCCmec Ⅲ型,pv l 基因均阴性,MLST 分型为 ST239,spa 分型为 t037型。结论首次在湖南地区临床分离的金黄色葡萄球菌中发现存在 sasX 基因,sasX 基因可能是导致医院持续感染的毒力因素之一,应密切关注其流行发展趋势。%OBJECTIVE To investigate the prevalence of sasX gene in Staphylococcus aureus (S .aureus) strains and explore the molecular epidemiological characteristics so as to reveal the prevalence of the gene in this area . METHODS A total of 128 clinical S .aureus isolates were collected from Xiangya Hospital ,Central South Universi-ty from Jan 2012 to Dec 2012 ,then the sasX gene was detected by using PCR ,the SCCmec Ⅲ genotypes were de-tected for the sasX-positive strains with the use of multiple PCR ,the pvl toxin gene was amplified by PCR ,the multilocus sequence typing (MLST) was conducted to determine the sequence types(STs) ,and the staphylococcal protein A sequence typing (spa) of the sasX-positive strains was performed .RESULTS Of the 128 strains of S .au-reus ,2 were detected positive for the sasX gene ,with the detection rate 1 .6% ;both of the 2 strains were identi-fied as methicillin-resistant S .aureus (MRSA) by cefoxitin ,all of the SCCmec Ⅲ genotypes were SCCmec Ⅲ ,and the pvl gene was detected

  7. Social Anxiety Scale for Adolescents (SAS-A: Psychometric properties in a Spanish-speaking population

    Directory of Open Access Journals (Sweden)

    José Olivares

    2005-01-01

    Full Text Available El objetivo de este estudio instrumental fue estudiar la estructura factorial y propiedades psicométricas de la Escala de Ansiedad Social para Adolescentes (SASA. Participaron 2407 adolescentes (1263 chicos y 1144 chicas, con una edad media de 15 años, alumnos de nueve institutos de la región de Murcia. Los resultados obtenidos apoyan la estructura tri-factorial propuesta por los autores de la escala (FNE, SAD-New, SAD-General. Se encontraron correlaciones interescalas significativas y niveles de consistencia interna elevados para las subescalas, así como respecto de los efectos del sexo en la puntuación SAS-A/Total y en sus subescalas, alcanzando las chicas las puntuaciones más elevadas. Sólo se hallaron diferencias significativas para la edad en la subescala FNE y no se constataron efectos de interacción entre los dos factores. Estos hallazgos parecen avalar el uso de la SAS-A en población adolescente de habla española.

  8. Preparation and Physicochemical Properties of 10-Hydroxycamptothecin (HCPT Nanoparticles by Supercritical Antisolvent (SAS Process

    Directory of Open Access Journals (Sweden)

    Baoyou Zhang

    2011-04-01

    Full Text Available The goal of the present work was to study the feasibility of 10-hydroxycamptothecin (HCPT nanoparticle preparation using supercritical antisolvent (SAS precipitation. The influences of various experimental factors on the mean particle size (MPS of HCPT nanoparticles were investigated. The optimum micronization conditions are determined as follows: HCPT solution concentration 0.5 mg/mL, the flow rate ratio of CO2 and HCPT solution 19.55, precipitation temperature 35 °C and precipitation pressure 20 MPa. Under the optimum conditions, HCPT nanoparticles with a MPS of 180 ± 20.3 nm were obtained. Moreover, the HCPT nanoparticles obtained were characterized by Scanning electron microscopy, Dynamic light scattering, Fourier-transform infrared spectroscopy, High performance liquid chromatography-mass spectrometry, X-ray diffraction and Differential scanning calorimetry analyses. The physicochemical characterization results showed that the SAS process had not induced degradation of HCPT. Finally, the dissolution rates of HCPT nanoparticles were investigated and the results proved that there is a significant increase in dissolution rate compared to unprocessed HCPT.

  9. Krāsas un atmosfēra Edgara Alana Po dzejā

    OpenAIRE

    Kļimova, Kristīna

    2009-01-01

    Bakalaura darba tēma ir krāsas un noskaņa Edgar Allana Po dzejā. Pētījuma uzdevums ir noteikt biežāk lietojamos tēlainās izteiksmes līdzekļus un krāsas Edgara Po dzejā, turklāt identificēt gaisotni un noskaņu šajos darbos. Darba autore ir veikusi pētījumu balstoties uz praktiskām un teorētiskām zināšanām. Teorētiskā daļa iztirzā tāda veida problēmas kā: tēlainās izteiksmes līdzekļu būtību, simbolu un simbolsisko krāsu izmantošana literatūrā, ka arī to nozīmi Edgara Allana Po dzejā, un cit...

  10. Efficiency prediction for a low head bulb turbine with SAS SST and zonal LES turbulence models

    Science.gov (United States)

    Jošt, D.; Škerlavaj, A.

    2014-03-01

    A comparison between results of numerical simulations and measurements for a 3-blade bulb turbine is presented in order to determine an appropriate numerical setup for accurate and reliable simulations of flow in low head turbines. Numerical analysis was done for three angles of runner blades at two values of head. For the smallest blade angle the efficiency was quite accurately predicted, but for the optimal and maximal blade angles steady state analysis entirely failed to predict the efficiency due to underestimated torque on the shaft and incorrect results in the draft tube. Transient simulation with SST did not give satisfactory results, but with SAS and zonal LES models the prediction of efficiency was significantly improved. From the results obtained by SAS and zonal LES the interdependence between turbulence models, vortex structures in the flow, values of eddy viscosity and flow energy losses in the draft tube can be seen. Also the effect of using the bounded central differential scheme instead of the high resolution scheme was evident. To test the effect of grid density, simulations were performed on four grids. While a difference between results obtained on the basic grid and on the fine grid was small, the results obtained on the coarse grids were not satisfactory.

  11. Comparing the importance of prognostic factors in Cox and logistic regression using SAS.

    Science.gov (United States)

    Heinze, Georg; Schemper, Michael

    2003-06-01

    Two SAS macro programs are presented that evaluate the relative importance of prognostic factors in the proportional hazards regression model and in the logistic regression model. The importance of a prognostic factor is quantified by the proportion of variation in the outcome attributable to this factor. For proportional hazards regression, the program %RELIMPCR uses the recently proposed measure V to calculate the proportion of explained variation (PEV). For the logistic model, the R(2) measure based on squared raw residuals is used by the program %RELIMPLR. Both programs are able to compute marginal and partial PEV, to compare PEVs of factors, of groups of factors, and even to compare PEVs of different models. The programs use a bootstrap resampling scheme to test differences of the PEVs of different factors. Confidence limits for P-values are provided. The programs further allow to base the computation of PEV on models with shrinked or bias-corrected parameter estimates. The SAS macros are freely available at www.akh-wien.ac.at/imc/biometrie/relimp

  12. Final SAS-2 gamma ray results on sources in the galactic anticenter region

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.; Lamb, R. C.

    1976-01-01

    Analysis of SAS-2 high energy Gamma ray data from the direction of the galactic anticenter shows that this region is characterized by: a diffuse emission from the galactic plane which has a maximum along b=0 deg and an enhancement toward negative latitudes associated with Gould's Belt, a strong point source in the direction of the Crab nebula, and a second intense localized source near galactic coordinates 195 deg, +5 deg. Gamma ray emission from the Crab source is dominated by a pulsed flux from PSR 0531+21. The total flux above 100MeV is 3.7 + or - 0.8 million/sq cm s. The source near 195 deg, + 5 deg has a flux above 100 MeV of 4.3 + or - 0.9 million/sq cm s. Its spectrum appears flatter than that of the Crab. The diffuse galactic plane emission at negative lattitudes shows a general correlation with the local matter distribution associated with Gould's Belt. The calculated Gamma ray intensity agrees well with the SAS-2 observations.

  13. Effects of 2D and 3D Error Fields on the SAS Divertor Magnetic Topology

    Science.gov (United States)

    Trevisan, G. L.; Lao, L. L.; Strait, E. J.; Guo, H. Y.; Wu, W.; Evans, T. E.

    2016-10-01

    The successful design of plasma-facing components in fusion experiments is of paramount importance in both the operation of future reactors and in the modification of operating machines. Indeed, the Small Angle Slot (SAS) divertor concept, proposed for application on the DIII-D experiment, combines a small incident angle at the plasma strike point with a progressively opening slot, so as to better control heat flux and erosion in high-performance tokamak plasmas. Uncertainty quantification of the error fields expected around the striking point provides additional useful information in both the design and the modeling phases of the new divertor, in part due to the particular geometric requirement of the striking flux surfaces. The presented work involves both 2D and 3D magnetic error field analysis on the SAS strike point carried out using the EFIT code for 2D equilibrium reconstruction, V3POST for vacuum 3D computations and the OMFIT integrated modeling framework for data analysis. An uncertainty in the magnetic probes' signals is found to propagate non-linearly as an uncertainty in the striking point and angle, which can be quantified through statistical analysis to yield robust estimates. Work supported by contracts DE-FG02-95ER54309 and DE-FC02-04ER54698.

  14. Development and validation of logistic prognostic models by predefined SAS-macros

    Directory of Open Access Journals (Sweden)

    Ziegler, Christoph

    2006-02-01

    Full Text Available In medical decision making about therapies or diagnostic procedures in the treatment of patients the prognoses of the course or of the magnitude of diseases plays a relevant role. Beside of the subjective attitude of the clinician mathematical models can help in providing such prognoses. Such models are mostly multivariate regression models. In the case of a dichotomous outcome the logistic model will be applied as the standard model. In this paper we will describe SAS-macros for the development of such a model, for examination of the prognostic performance, and for model validation. The rational for this developmental approach of a prognostic modelling and the description of the macros can only given briefly in this paper. Much more details are given in. These 14 SAS-macros are a tool for setting up the whole process of deriving a prognostic model. Especially the possibility of validating the model by a standardized software tool gives an opportunity, which is not used in general in published prognostic models. Therefore, this can help to develop new models with good prognostic performance for use in medical applications.

  15. [Use of the anatomical cemented femoral stem SAS I: mid-term results].

    Science.gov (United States)

    Mikláš, M; Pink, M; Valoušek, T

    2015-01-01

    PURPOSE OF THE STUDY In view of increasing interest in a relationship between the surface of an implant and its behaviour and longevity in total hip arthroplasty (THA), the aim of this study is to present the clinical and radiographic results, as well as complications, of hip replacement surgery using the cemented femoral stem SAS I. MATERIAL AND METHODS A total of 298 cemented femoral stems SAS I were implanted in 275 patients at our department between 1996 and 2005. The patient average age was 72.1 years, with the range from 64 to 92 years. The pre-operative diagnoses were as follows: primary osteoarthritis in 179 (30.1%); post-dysplastic osteoarthritis in 41 (13.7%); femoral neck fracture in 44 (14.8%); avascular necrosis of the femoral head in 23 (7.7%); rheumatoid arthritis in nine (3%) and other causes in two (0.7%) patients. Of the 275 patients who had the surgery, 186 (204 THAs) underwent clinical and X-ray examination at an average follow-up of 11.5 years (range, 8 to 17 years). The clinical results were used to calculate the Harris hip score and radiographic evaluation was based on antero-posterior views. RESULTS The group of 186 assessed patients (204 THAs) comprised 106 women and 80 men, who were on average 85.4 years old on evaluation (range, 72 to 92 years). Of the remaining patients, 62 patients (64 THAs) died from causes unrelated to the surgery and 27 patients (30 THAs) were lost to follow-up. The functional outcome of surgery assessed by the Harris hip score was excellent in 61 (32.8%), good in 94 (50.5%), satisfactory in 26 (14%) and poor in five (2.7%) patients. The 93.1% SAS I stem longevity was recorded in relation to aseptic loosening; reimplantation for this indication was performed in 14 THAs. No revision surgery for failure due to valgus/varus deviations of the stem was carried out. Of the 204 hips, 188 had femoral stems aligned in neutral, 12 (5.9%) in valgus and four (2%) in varus positions. DISCUSSION The anatomical femoral stem SAS I

  16. The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies.

    Science.gov (United States)

    Cottee, Matthew A; Muschalik, Nadine; Johnson, Steven; Leveson, Joanna; Raff, Jordan W; Lea, Susan M

    2015-05-23

    Sas-6 and Ana2/STIL proteins are required for centriole duplication and the homo-oligomerisation properties of Sas-6 help establish the ninefold symmetry of the central cartwheel that initiates centriole assembly. Ana2/STIL proteins are poorly conserved, but they all contain a predicted Central Coiled-Coil Domain (CCCD). Here we show that the Drosophila Ana2 CCCD forms a tetramer, and we solve its structure to 0.8 Å, revealing that it adopts an unusual parallel-coil topology. We also solve the structure of the Drosophila Sas-6 N-terminal domain to 2.9 Å revealing that it forms higher-order oligomers through canonical interactions. Point mutations that perturb Sas-6 or Ana2 homo-oligomerisation in vitro strongly perturb centriole assembly in vivo. Thus, efficient centriole duplication in flies requires the homo-oligomerisation of both Sas-6 and Ana2, and the Ana2 CCCD tetramer structure provides important information on how these proteins might cooperate to form a cartwheel structure.

  17. Realization of data analysis system for Internet negotiation based on SAS/IntrNet%基于SAS/IntrNet的网上谈判数据分析系统的实现

    Institute of Scientific and Technical Information of China (English)

    冯玉强; 马兴辉

    2005-01-01

    针对SAS统计分析系统局限于单机应用的现状,提出了SAS与Web服务器相结合的方式来弥补SAS系统在Web环境下应用的不足,介绍了利用SAS/IntrNet实现SAS的Web应用的基本原理,给出了SAS/IntrNet程序处理的一般流程和相关配置文件的详细配置方法,解决了SAS/IntrNet系统实现中的几个关键问题.同时给出这一应用的具体实例--网上谈判数据分析系统的具体实现方法.

  18. GLUMIP 2.0: SAS/IML Software for Planning Internal Pilots

    Directory of Open Access Journals (Sweden)

    John A. Kairalla

    2008-09-01

    Full Text Available Internal pilot designs involve conducting interim power analysis (without interim data analysis to modify the final sample size. Recently developed techniques have been described to avoid the type~I error rate inflation inherent to unadjusted hypothesis tests, while still providing the advantages of an internal pilot design. We present GLUMIP 2.0, the latest version of our free SAS/IML software for planning internal pilot studies in the general linear univariate model (GLUM framework. The new analytic forms incorporated into the updated software solve many problems inherent to current internal pilot techniques for linear models with Gaussian errors. Hence, the GLUMIP 2.0 software makes it easy to perform exact power analysis for internal pilots under the GLUM framework with independent Gaussian errors and fixed predictors.

  19. Computational procedures for probing interactions in OLS and logistic regression: SPSS and SAS implementations.

    Science.gov (United States)

    Hayes, Andrew F; Matthes, Jörg

    2009-08-01

    Researchers often hypothesize moderated effects, in which the effect of an independent variable on an outcome variable depends on the value of a moderator variable. Such an effect reveals itself statistically as an interaction between the independent and moderator variables in a model of the outcome variable. When an interaction is found, it is important to probe the interaction, for theories and hypotheses often predict not just interaction but a specific pattern of effects of the focal independent variable as a function of the moderator. This article describes the familiar pick-a-point approach and the much less familiar Johnson-Neyman technique for probing interactions in linear models and introduces macros for SPSS and SAS to simplify the computations and facilitate the probing of interactions in ordinary least squares and logistic regression. A script version of the SPSS macro is also available for users who prefer a point-and-click user interface rather than command syntax.

  20. Estimation of the concordance correlation coefficient for repeated measures using SAS and R.

    Science.gov (United States)

    Carrasco, Josep L; Phillips, Brenda R; Puig-Martinez, Josep; King, Tonya S; Chinchilli, Vernon M

    2013-03-01

    The concordance correlation coefficient is one of the most common approaches used to assess agreement among different observers or instruments when the outcome of interest is a continuous variable. A SAS macro and R package are provided here to estimate the concordance correlation coefficient (CCC) where the design of the data involves repeated measurements by subject and observer. The CCC is estimated using U-statistics (UST) and variance components (VC) approaches. Confidence intervals and standard errors are reported along with the point estimate of the CCC. In the case of the VC approach, the linear mixed model output and variance components estimates are also provided. The performance of each function is shown by means of some examples with real data sets.

  1. Valoración de empresa Haceb Whirpool Industrial S.A.S.

    OpenAIRE

    Giraldo Cardona, Juan Camilo

    2015-01-01

    Este trabajo presenta la valoración de la empresa Haceb Whirlpool Industrial S.A.S. -- En la primera sección se describe la situación en estudio a través de la presentación de la empresa, una breve reseña histórica de cada uno de los accionistas, información del mercado de electrodomésticos en Colombia (especialmente la relacionada con el mercado de lavadoras), también se describe qué es un Joint Venture y por último la pertinencia de la valoración para los órganos de dirección -- En la segun...

  2. [Calculating Pearson residual in logistic regressions: a comparison between SPSS and SAS].

    Science.gov (United States)

    Xu, Hao; Zhang, Tao; Li, Xiao-song; Liu, Yuan-yuan

    2015-01-01

    To compare the results of Pearson residual calculations in logistic regression models using SPSS and SAS. We reviewed Pearson residual calculation methods, and used two sets of data to test logistic models constructed by SPSS and STATA. One model contained a small number of covariates compared to the number of observed. The other contained a similar number of covariates as the number of observed. The two software packages produced similar Pearson residual estimates when the models contained a similar number of covariates as the number of observed, but the results differed when the number of observed was much greater than the number of covariates. The two software packages produce different results of Pearson residuals, especially when the models contain a small number of covariates. Further studies are warranted.

  3. Plan estratégico para la empresa A.L Telecomunicaciones S.A.S

    OpenAIRE

    Martínez Ascencio, Nohra Alejandra; Fonseca Torrijos, Camila Andrea

    2016-01-01

    El presente trabajo está constituido por cinco capítulos en los que se desarrolla el plan estratégico para la empresa A.L Telecomunicaciones S.A.S. El primer capítulo expone los antecedentes de la compañía y por qué se hace necesaria la elaboración del plan estratégico para el nuevo negocio de la empresa. En el segundo capítulo se elabora la fundamentación teórica, donde se describe la importancia de la planeación estratégica y el direccionamiento estratégico y los conceptos fundamental...

  4. SAS-2 observations of the high energy gamma radiation from the Vela region

    Science.gov (United States)

    Thompson, D. J.; Bignami, G. F.; Fichtel, C. E.; Kniffen, D. A.

    1974-01-01

    Data from a scan of the galactic plane by the SAS-B high energy gamma ray experiment in the region 250 deg smaller than 12 smaller than 290 deg show a statistically significant excess over the general radiation from the galactic plane for gamma radiation of energy larger than 100 MeV. If the enhanced gamma radiation results from interactions of cosmic rays with galactic matter, as the energy spectrum suggests, it seems reasonable to associate the enhancement with large scale galactic features, such as spiral arm segments in that direction, or with the region surrounding the Vela supernova remnant with which PSR 0833-45 is associated. If the excess is attributed to cosmic rays released from the supernova interacting with the interstellar matter in that region, than on the order of 3 x 10 to the 50th power ergs would have been released by that supernova in the form of cosmic rays.

  5. McSAS: A package for extracting quantitative form-free distributions

    CERN Document Server

    Breßler, Ingo; Thünemann, Andreas

    2014-01-01

    A reliable and user-friendly characterisation of nano-objects in a target material is presented here in the form of a software data analysis package for interpreting small-angle X-ray scattering (SAXS) patterns. When provided with data on absolute scale with reasonable uncertainty estimates, the software outputs (size) distributions in absolute volume fractions complete with uncertainty estimates and minimum evidence limits, and outputs all distribution modes of a user definable range of one or more model parameters. A multitude of models are included, including prolate and oblate nanoparticles, core-shell objects, polymer models (Gaussian chain and Kholodenko worm) and a model for densely packed spheres (using the LMA-PY approximations). The McSAS software can furthermore be integrated as part of an automated reduction and analysis procedure in laboratory instruments or at synchrotron beamlines.

  6. The dental X-ray file of crew members in the Scandinavian Airlines System (SAS).

    Science.gov (United States)

    Keiser-Nielsen, S; Johanson, G; Solheim, T

    1981-11-01

    In 1977, the Scandinavian Airlines System (SAS) established a dental X-ray file of all crew members. Its aim was to have immediately available an adequate set of physical antemortem data useful for identification in case of a fatal crash. Recently, an investigation into the quality and suitability of this material was carried out. The radiographs of 100 Danish, 100 Norwegian, and 100 Swedish pilots were picked at random and evaluated for formal deficiences, technical deficiencies, treatment pattern as useful for identification purposes, and the presence of pathology. The major results of the investigation were that a number of formal and technical deficiencies were disclosed, that the treatment pattern would seem adequate for identification purposes, and that a number of pathological findings were made, several of which had to be considered possible safety risks in the form of barodontalgia.

  7. SAS-2 high-energy gamma-ray observations of the Vela pulsar

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Kniffen, D. A.; Ogelman, H. B.

    1975-01-01

    The Second Small Astronomy Satellite (SAS-2) high-energy (in excess of 35 MeV) gamma-ray telescope has detected pulsed gamma-ray emission at the radio period from PSR 0833-45, the Vela pulsar, as well as an unpulsed flux from the Vela region. The pulsed emission consists of two peaks following the single radio peak by about 13 ms and 48 ms. The luminosity of the pulsed emission above 100 MeV from Vela is about 0.1 that of the pulsar NP 0532 in the Crab nebula, whereas the pulsed emission from Vela at optical wavelengths is less than 0.0002 that from the Crab. The relatively high intensity of the pulsed gamma-ray emission, and the double peak structure, compared with the single pulse in the radio emission, suggest that the high-energy gamma-ray pulsar emission may be produced under different conditions from those at lower energies.

  8. SAS-2 observations of gamma rays from the galactic plane. [noting longitude and latitude observation

    Science.gov (United States)

    Thompson, D. J.; Bignami, G. F.; Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.

    1974-01-01

    Preliminary data are given for the SAS-2 high energy galactic gamma ray observation. These data include both latitude and longitude distributions. The longitude distribution shows a high density region. The latitude distributions toward the center and the anti-center are markedly different, the former showing a two-component structure of half-widths of approximately 3 and 6 deg. The energy spectrum in the range 35 to 200 MeV is hard, consistent with cosmic ray interactions with interstellar matter, including neutral pions decay and emission from energetic electron interactions. The data is consistent with an interpretation in terms of the confinement of the cosmic rays in the spiral arms.

  9. Final SAS-2 gamma-ray results on sources in the galactic anticenter region

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.; Lamb, R. C.

    1977-01-01

    Final results are presented for SAS-2 observations of high-energy gamma-rays from the galactic anticenter region. Three main gamma-ray features are shown to characterize this region: a localized source associated with the Crab Nebula and its pulsar, another localized source near galactic coordinates 195 deg, +5 deg, and a general enhancement of the diffuse background 10 to 15 deg south of the galactic plane, which is associated with the Gould Belt. For the Crab, it is found that the radiation is mostly pulsed, the pulsed fraction increases with energy, and the intensity of the radiation in the main and interpulse peaks is approximately the same. The other localized source, provisionally designated as gamma 195+5, is found to have a harder spectrum than the Crab but no obvious radio counterpart; emission from an external galaxy is ruled out.

  10. SAS-2 gamma-ray observations of PSR 1747-46. [radio pulsar

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Kniffen, D. A.; Ogelman, H. B.; Lamb, R. C.

    1976-01-01

    Evidence is reported for the observation of gamma-ray emission from the radio pulsar PSR 1747-46 by the gamma-ray telescope aboard SAS 2. The evidence is based on the presence of both an approximately 3-sigma enhancement of gamma rays at the pulsar's location and an approximately 4-sigma peak in the phase plot of 79 gamma-ray events whose phase was calculated from the pulsar's known period. The gamma-ray pulsation is found to appear at a phase lag of about 0.16 from that predicted by the radio observations. The pulsed gamma-ray fluxes above 35 MeV and 100 MeV are estimated, and it is shown that the gamma-ray pulse width is similar to the radio pulse width. It is concluded that PSR 1747-46 is a most likely candidate for pulsed gamma-ray emission.

  11. Numerical Investigation of Pressure Fluctuation in Centrifugal Pump Volute Based on SAS Model and Experimental Validation

    Directory of Open Access Journals (Sweden)

    Qiaorui Si

    2014-02-01

    Full Text Available This paper presents an investigation of pressure fluctuation of a single-suction volute-type centrifugal pump, particularly volute casing, by using numerical and experimental methods. A new type of hybrid Reynolds-averaged Navier-Stokes/Large Eddy Simulation, referred to as the shear stress transport-scale-adaptive simulation (SAS model, is employed to study the unsteady flow. Statistical analysis method is adopted to show the pressure fluctuation intensity distribution in the volute channel. A test rig for pressure pulsation measurement is built to validate the numerical simulation results using eight transient pressure sensors in the middle section of the volute wall. Results show that the SAS model can accurately predict the inner flow field of centrifugal pumps. Radial force acting on the impeller presents a star distribution related to the blade number. Pressure fluctuation intensity is strongest near the tongue and shows irregular distribution in the pump casing. Pressure fluctuation is distributed symmetrically at the cross-section of the volute casing because the volute can eliminate the rotational movement of the liquid discharged from the impeller. Blade passing frequency and its multiples indicate the dominant frequency of the monitoring points within the volute, and the low-frequency pulsation, particularly in the shaft component, increases when it operates at off-design condition, particularly with a small flow rate. The reason is that the vortex wave is enhanced at the off-design condition, which has an effect on the axle and is presented in the shaft component in the frequency domain.

  12. Integrative Biological Chemistry Program Includes The Use Of Informatics Tools, GIS And SAS Software Applications.

    Science.gov (United States)

    D'Souza, Malcolm J; Kashmar, Richard J; Hurst, Kent; Fiedler, Frank; Gross, Catherine E; Deol, Jasbir K; Wilson, Alora

    Wesley College is a private, primarily undergraduate minority-serving institution located in the historic district of Dover, Delaware (DE). The College recently revised its baccalaureate biological chemistry program requirements to include a one-semester Physical Chemistry for the Life Sciences course and project-based experiential learning courses using instrumentation, data-collection, data-storage, statistical-modeling analysis, visualization, and computational techniques. In this revised curriculum, students begin with a traditional set of biology, chemistry, physics, and mathematics major core-requirements, a geographic information systems (GIS) course, a choice of an instrumental analysis course or a statistical analysis systems (SAS) programming course, and then, students can add major-electives that further add depth and value to their future post-graduate specialty areas. Open-sourced georeferenced census, health and health disparity data were coupled with GIS and SAS tools, in a public health surveillance system project, based on US county zip-codes, to develop use-cases for chronic adult obesity where income, poverty status, health insurance coverage, education, and age were categorical variables. Across the 48 contiguous states, obesity rates are found to be directly proportional to high poverty and inversely proportional to median income and educational achievement. For the State of Delaware, age and educational attainment were found to be limiting obesity risk-factors in its adult population. Furthermore, the 2004-2010 obesity trends showed that for two of the less densely populated Delaware counties; Sussex and Kent, the rates of adult obesity were found to be progressing at much higher proportions when compared to the national average.

  13. Contribution à l’amélioration du procédé d’élaboration de la tequila par l’utilisation d’enzymes

    OpenAIRE

    Waleckx, Etienne

    2007-01-01

    Les objectifs de ce travail étaient : (i) la substitution, dans un procédé d’élaboration de tequila, du traitement chimique du jus de cuisson de l’agave – appliqué pour hydrolyser les fructanes non dégradés lors de la cuisson et rendre tous les sucres disponibles - par un traitement enzymatique, (ii) sa validation au niveau industriel, (iii) l’évaluation de l’utilisation d’enzymes de dégradation de la paroi végétale pour faciliter l’étape de pressage de l’agave. Les bilans sur ...

  14. Comment to the paper: 'Seeded quantum FEL at 478 keV' AIP Conf. Proc. 'Light at Extreme Intensities' 1462 173-176 (2012)'

    CERN Document Server

    Petrillo, Vittoria

    2012-01-01

    We criticize the thesis exposed the paper 'Seeded quantum FEL at 478 keV' AIP Conf. Proc. 'Light at Extreme Intensities,' 1462 173-176 (2012), which presents the possibility of producing gamma rays at 478 KeV by means of a seeded quantum FEL driven by an electron beam at 125 MeV, current I=40 A, interacting with an infrared laser. We show that, in the case analyzed, the FEL Pierce parameter has a value two orders of magnitude less than what claimed in the paper in question, overturning the conclusions of the analysis.

  15. Proteomic analysis of cellular response induced by boron neutron capture reaction in human squamous cell carcinoma SAS cells.

    Science.gov (United States)

    Sato, Akira; Itoh, Tasuku; Imamichi, Shoji; Kikuhara, Sota; Fujimori, Hiroaki; Hirai, Takahisa; Saito, Soichiro; Sakurai, Yoshinori; Tanaka, Hiroki; Nakamura, Hiroyuki; Suzuki, Minoru; Murakami, Yasufumi; Baiseitov, Diaz; Berikkhanova, Kulzhan; Zhumadilov, Zhaxybay; Imahori, Yoshio; Itami, Jun; Ono, Koji; Masunaga, Shinichiro; Masutani, Mitsuko

    2015-12-01

    To understand the mechanism of cell death induced by boron neutron capture reaction (BNCR), we performed proteome analyses of human squamous tumor SAS cells after BNCR. Cells were irradiated with thermal neutron beam at KUR after incubation under boronophenylalanine (BPA)(+) and BPA(-) conditions. BNCR mainly induced typical apoptosis in SAS cells 24h post-irradiation. Proteomic analysis in SAS cells suggested that proteins functioning in endoplasmic reticulum, DNA repair, and RNA processing showed dynamic changes at early phase after BNCR and could be involved in the regulation of cellular response to BNCR. We found that the BNCR induces fragments of endoplasmic reticulum-localized lymphoid-restricted protein (LRMP). The fragmentation of LRMP was also observed in the rat tumor graft model 20 hours after BNCT treatment carried out at the National Nuclear Center of the Republic of Kazakhstan. These data suggest that dynamic changes of LRMP could be involved during cellular response to BNCR.

  16. Physicochemical properties and oral bioavailability of amorphous atorvastatin hemi-calcium using spray-drying and SAS process.

    Science.gov (United States)

    Kim, Jeong-Soo; Kim, Min-Soo; Park, Hee Jun; Jin, Shun-Ji; Lee, Sibeum; Hwang, Sung-Joo

    2008-07-09

    The objective of the study was to prepare amorphous atorvastatin hemi-calcium using spray-drying and supercritical antisolvent (SAS) process and evaluate its physicochemical properties and oral bioavailability. Atorvastatin hemi-calcium trihydrate was transformed to anhydrous amorphous form by spray-drying and SAS process. With the SAS process, the mean particle size and the specific surface area of amorphous atorvastatin were drastically changed to 68.7+/-15.8nm, 120.35+/-1.40m2/g and 95.7+/-12.2nm, 79.78+/-0.93m2/g from an acetone solution and a tetrahydrofuran solution, respectively and appeared to be associated with better performance in apparent solubility, dissolution and pharmacokinetic studies, compared with unprocessed crystalline atorvastatin. Oral AUC0-8h values in SD rats for crystalline and amorphous atorvastatin were as follow: 1121.4+/-212.0ngh/mL for crystalline atorvastatin, 3249.5+/-406.4ngh/mL and 3016.1+/-200.3ngh/mL for amorphous atorvastatin from an acetone solution and a tetrahydrofuran solution with SAS process, 2227.8+/-274.5 and 2099.9+/-339.2ngh/mL for amorphous atorvastatin from acetone and tetrahydrofuran with spray-drying. The AUCs of all amorphous atorvastatin significantly increased (PSAS process exhibits better bioavailability than spray-drying because of particle size reduction with narrow particle size distribution. It was concluded that physicochemical properties and bioavailability of crystalline atorvastatin could be improved by physical modification such as particle size reduction and generation of amorphous state using spray-drying and SAS process. Further, SAS process was a powerful methodology for improving the physicochemical properties and bioavailability of atorvastatin.

  17. ARP: Automatic rapid processing for the generation of problem dependent SAS2H/ORIGEN-s cross section libraries

    Energy Technology Data Exchange (ETDEWEB)

    Leal, L.C.; Hermann, O.W.; Bowman, S.M.; Parks, C.V.

    1998-04-01

    In this report, a methodology is described which serves as an alternative to the SAS2H path of the SCALE system to generate cross sections for point-depletion calculations with the ORIGEN-S code. ARP, Automatic Rapid Processing, is an algorithm that allows the generation of cross-section libraries suitable to the ORIGEN-S code by interpolation over pregenerated SAS2H libraries. The interpolations are carried out on the following variables: burnup, enrichment, and water density. The adequacy of the methodology is evaluated by comparing measured and computed spent fuel isotopic compositions for PWR and BWR systems.

  18. A leave-one-out cross-validation SAS macro for the identification of markers associated with survival.

    Science.gov (United States)

    Rushing, Christel; Bulusu, Anuradha; Hurwitz, Herbert I; Nixon, Andrew B; Pang, Herbert

    2015-02-01

    A proper internal validation is necessary for the development of a reliable and reproducible prognostic model for external validation. Variable selection is an important step for building prognostic models. However, not many existing approaches couple the ability to specify the number of covariates in the model with a cross-validation algorithm. We describe a user-friendly SAS macro that implements a score selection method and a leave-one-out cross-validation approach. We discuss the method and applications behind this algorithm, as well as details of the SAS macro.

  19. SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules.

    Science.gov (United States)

    Dammermann, Alexander; Maddox, Paul S; Desai, Arshad; Oegema, Karen

    2008-02-25

    Centrioles are surrounded by pericentriolar material (PCM), which is proposed to promote new centriole assembly by concentrating gamma-tubulin. Here, we quantitatively monitor new centriole assembly in living Caenorhabditis elegans embryos, focusing on the conserved components SAS-4 and SAS-6. We show that SAS-4 and SAS-6 are coordinately recruited to the site of new centriole assembly and reach their maximum levels during S phase. Centriolar SAS-6 is subsequently reduced by a mechanism intrinsic to the early assembly pathway that does not require progression into mitosis. Centriolar SAS-4 remains in dynamic equilibrium with the cytoplasmic pool until late prophase, when it is stably incorporated in a step that requires gamma-tubulin and microtubule assembly. These results indicate that gamma-tubulin in the PCM stabilizes the nascent daughter centriole by promoting microtubule addition to its outer wall. Such a mechanism may help restrict new centriole assembly to the vicinity of preexisting parent centrioles that recruit PCM.

  20. Ús dels blogs com a suport al procés d'ensenyament i aprenentatge en l'Educació Superior

    Directory of Open Access Journals (Sweden)

    Francesc Balagué-Puxan

    2011-01-01

    Full Text Available Crear un compte, triar un títol i una plantilla. Amb aquestes tres simples accions, Blogger anuncia la senzillesa de crear un blog. Però aquesta senzillesa no té res a veure amb la complexitat de l’ús d’aquestes plataformes en un context educatiu.Es presenta una recerca basada en l’educació superior, concretament en l’ús del blog com a suport al procés d’ensenyament i aprenentatge. S’han fet tres estudis de cas. Els dos primers, basats en dos grups d’estudiants ben diferents, i un tercer cas basat en el mateix blog que documenta, des del seu inici, tot el procés de desenvolupament de la tesi.Aquests casos es complementen amb una extensa revisió bibliogràfica i entrevistes a diferents professors pioners en l’ús de les tecnologies aplicades a la seva docència.A partir de les conclusions, s’obren noves línies de recerca. Una de les més destacades és la mateixa evolució de l’eina i el que s’anomena entorns personals d’aprenentatge (PLE.

  1. Design of a Road Friendly SAS System for Heavy-Duty Vehicles Based on a Fuzzy-Hybrid-ADD and GH-Control Strategy

    OpenAIRE

    Jing Zhao; Pak Kin Wong; Zhengchao Xie; Xinbo Ma; Caiyang Wei

    2016-01-01

    Semiactive suspension (SAS) system has been widely used for its outstanding performance in offering competent ride quality, road holding, and handling capacity. However, the road friendliness is also one of the crucial factors that should be attached in the design of the SAS system for heavy-duty vehicles. In this study, a fuzzy controlled hybrid-acceleration driven damper (ADD) and ground hook- (GH-) control strategy is proposed for SAS system of heavy-duty vehicles. Firstly, a quarter-vehic...

  2. Monoclonal Antibody Targeting Staphylococcus aureus Surface Protein A (SasA) Protect Against Staphylococcus aureus Sepsis and Peritonitis in Mice.

    Science.gov (United States)

    Yang, Yilong; Qian, Mengying; Yi, Shaoqiong; Liu, Shuling; Li, Bing; Yu, Rui; Guo, Qiang; Zhang, Xiaopeng; Yu, Changming; Li, Jianmin; Xu, Junjie; Chen, Wei

    2016-01-01

    Epidemic methicillin-resistant Staphylococcus aureus (MRSA) imposes an increasing impact on public health. Due to multi-antibiotics resistance in MRSA strains, there is an urgent need to develop novel therapeutics such as effective monoclonal antibodies (mAbs) against MRSA infections. Staphylococcus aureus surface protein A (SasA), a large surface-located protein (~240 kDa), is one of MSCRAMMs (microbial surface components recognizing adhesive matrix molecules) and a potential target for immunotherapeutic approaches against S. aureus infections. In the present study, we analyzed the sequence of SasA with bioinformatics tools and generated a protective monoclonal antibody (2H7) targeting the conserved domain of SasA. 2H7 was shown to recognize wild-type S. aureus and promote opsonophagocytic killing of S. aureus. In both sepsis and peritoneal infection models, prophylactic administration of 2H7 improved the survival of BALB/c mice challenged by S. aureus strain USA300 and ST239 (prevalent MRSA clones in North America and Asian countries, respectively) and enhanced bacterial clearance in kidneys. Additionally, 2H7 prophylaxis prevented the formation of intraperitoneal abscess in a murine model of peritoneal infection and therapeutic administration of 2H7 showed protective efficacy in a murine sepsis model. Our results presented here provide supporting evidences that an anti-SasA mAb might be a potential component in an antibody-based immunotherapeutic treatment of MRSA infections.

  3. SAS Code for Calculating Intraclass Correlation Coefficients and Effect Size Benchmarks for Site-Randomized Education Experiments

    Science.gov (United States)

    Brandon, Paul R.; Harrison, George M.; Lawton, Brian E.

    2013-01-01

    When evaluators plan site-randomized experiments, they must conduct the appropriate statistical power analyses. These analyses are most likely to be valid when they are based on data from the jurisdictions in which the studies are to be conducted. In this method note, we provide software code, in the form of a SAS macro, for producing statistical…

  4. Development and validation of the self-acceptance scale for persons with early blindness: the SAS-EB.

    Science.gov (United States)

    Morgado, Fabiane Frota da Rocha; Campana, Angela Nogueira Neves Betanho; Tavares, Maria da Consolação Gomes Cunha Fernandes

    2014-01-01

    Investigations of self-acceptance are critical to understanding the development and maintenance of psychological health. However, valid and reliable instruments for measuring self-acceptance in persons with early blindness have yet to be developed. The current research describes three studies designed to develop and validate the Self-acceptance Scale for Persons with Early Blindness (SAS-EB). In Study 1, we developed the initial item pool. Thirty-three items were generated, based on data from specialized literature and from 2 focus groups. Items were organized in a three-factor structure, theoretically predicted for SAS-EB - (1) body acceptance, (2) self-protection from social stigmas, and (3) feeling and believing in one's capacities. In Study 2, information obtained from a panel of 9 experts and 22 persons with early blindness representing the target population was used to refine the initial item pool, generating a new pool of 27 items. In Study 3, 318 persons with early blindness (141 women and 177 men), between 18 and 60 years of age (M = 37.74 years, SD = 12.37) answered the new pool of 27 items. After the elimination of 9 items using confirmatory factor analysis, we confirmed the theoretical three-factor structure of the SAS-EB. Study 3 also provided support for the scale's internal consistency and construct validity. Finally, the psychometric properties of the SAS-EB, its utility, and its limitations are discussed along with considerations for future research.

  5. An essential role of the basal body protein SAS-6 in Plasmodium male gamete development and malaria transmission.

    Science.gov (United States)

    Marques, Sara R; Ramakrishnan, Chandra; Carzaniga, Raffaella; Blagborough, Andrew M; Delves, Michael J; Talman, Arthur M; Sinden, Robert E

    2015-02-01

    Gametocytes are the sole Plasmodium parasite stages that infect mosquitoes; therefore development of functional gametes is required for malaria transmission. Flagellum assembly of the Plasmodium male gamete differs from that of most other eukaryotes in that it is intracytoplasmic but retains a key conserved feature: axonemes assemble from basal bodies. The centriole/basal body protein SAS-6 normally regulates assembly and duplication of these organelles and its depletion causes severe flagellar/ciliary abnormalities in a diverse array of eukaryotes. Since basal body and flagellum assembly are intimately coupled to male gamete development in Plasmodium, we hypothesized that SAS-6 disruption may cause gametogenesis defects and perturb transmission. We show that Plasmodium berghei sas6 knockouts display severely abnormal male gametogenesis presenting reduced basal body numbers, axonemal assembly defects and abnormal nuclear allocation. The defects in gametogenesis reduce fertilization and render Pbsas6 knockouts less infectious to mosquitoes. Additionally, we show that lack of Pbsas6 blocks transmission from mosquito to vertebrate host, revealing an additional yet undefined role in ookinete to sporulating oocysts transition. These findings underscore the vulnerability of the basal body/SAS-6 to malaria transmission blocking interventions.

  6. Integrating SAS and GIS software to improve habitat-use estimates from radiotelemetry data

    Science.gov (United States)

    Kenow, K.P.; Wright, R.G.; Samuel, M.D.; Rasmussen, P.W.

    2001-01-01

    Radiotelemetry has been used commonly to remotely determine habitat use by a variety of wildlife species. However, habitat misclassification can occur because the true location of a radiomarked animal can only be estimated. Analytical methods that provide improved estimates of habitat use from radiotelemetry location data using a subsampling approach have been proposed previously. We developed software, based on these methods, to conduct improved habitat-use analyses. A Statistical Analysis System (SAS)-executable file generates a random subsample of points from the error distribution of an estimated animal location and formats the output into ARC/INFO-compatible coordinate and attribute files. An associated ARC/INFO Arc Macro Language (AML) creates a coverage of the random points, determines the habitat type at each random point from an existing habitat coverage, sums the number of subsample points by habitat type for each location, and outputs tile results in ASCII format. The proportion and precision of habitat types used is calculated from the subsample of points generated for each radiotelemetry location. We illustrate the method and software by analysis of radiotelemetry data for a female wild turkey (Meleagris gallopavo).

  7. Acetyltransferase SAS2 and sirtuin SIR2, respectively, control flocculation and biofilm formation in wine yeast.

    Science.gov (United States)

    Rodriguez, María E; Orozco, Helena; Cantoral, Jesús M; Matallana, Emilia; Aranda, Agustín

    2014-09-01

    Cell-to-cell and cell-to-environment interactions of microorganisms are of substantial relevance for their biotechnological use. In the yeast Saccharomyces cerevisiae, flocculation can be an advantage to clarify final liquid products after fermentation, and biofilm formation may be relevant for the encapsulation of strains of interest. The adhesion properties of wine yeast strains can be modified by the genetic manipulation of transcriptional regulatory proteins, such as histone deacetylases, and acetylases. Sirtuin SIR2 is essential for the formation of mat structures, a kind of biofilm that requires the expression of cell-wall protein FLO11 as its deletion reduces FLO11 expression, and adhesion of cells to themselves and to agar in a commercial wine strain. Deletion of acetyltransferase GCN5 leads to a similar phenotype. A naturally flocculant wine yeast strain called P2 was characterized. Its flocculation happens only during grape juice fermentation and is due to the presence of a highly transcribed version of flocculin FLO5, linked to the presence of a δ sequence in the promoter. Deletion of acetyltransferase SAS2 enhances this phenotype and maltose fermentation even more. Therefore, the manipulation of acetylation/deacetylation machinery members is a valid way to alter the interaction of industrial yeast to their environment.

  8. Design of experiment and data analysis by JMP (SAS institute) in analytical method validation.

    Science.gov (United States)

    Ye, C; Liu, J; Ren, F; Okafo, N

    2000-08-15

    Validation of an analytical method through a series of experiments demonstrates that the method is suitable for its intended purpose. Due to multi-parameters to be examined and a large number of experiments involved in validation, it is important to design the experiments scientifically so that appropriate validation parameters can be examined simultaneously to provide a sound, overall knowledge of the capabilities of the analytical method. A statistical method through design of experiment (DOE) was applied to the validation of a HPLC analytical method for the quantitation of a small molecule in drug product in terms of intermediate precision and robustness study. The data were analyzed in JMP (SAS institute) software using analyses of variance method. Confidence intervals for outcomes and control limits for individual parameters were determined. It was demonstrated that the experimental design and statistical analysis used in this study provided an efficient and systematic approach to evaluating intermediate precision and robustness for a HPLC analytical method for small molecule quantitation.

  9. The ZpiM algorithm: a method for interferometric image reconstruction in SAR/SAS.

    Science.gov (United States)

    Dias, José M B; Leitao, José M N

    2002-01-01

    This paper presents an effective algorithm for absolute phase (not simply modulo-2-pi) estimation from incomplete, noisy and modulo-2pi observations in interferometric aperture radar and sonar (InSAR/InSAS). The adopted framework is also representative of other applications such as optical interferometry, magnetic resonance imaging and diffraction tomography. The Bayesian viewpoint is adopted; the observation density is 2-pi-periodic and accounts for the interferometric pair decorrelation and system noise; the a priori probability of the absolute phase is modeled by a compound Gauss-Markov random field (CGMRF) tailored to piecewise smooth absolute phase images. We propose an iterative scheme for the computation of the maximum a posteriori probability (MAP) absolute phase estimate. Each iteration embodies a discrete optimization step (Z-step), implemented by network programming techniques and an iterative conditional modes (ICM) step (pi-step). Accordingly, the algorithm is termed ZpiM, where the letter M stands for maximization. An important contribution of the paper is the simultaneous implementation of phase unwrapping (inference of the 2pi-multiples) and smoothing (denoising of the observations). This improves considerably the accuracy of the absolute phase estimates compared to methods in which the data is low-pass filtered prior to unwrapping. A set of experimental results, comparing the proposed algorithm with alternative methods, illustrates the effectiveness of our approach.

  10. Evaluation of sleep apnea syndrome (SAS) with low field MR fluoroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Fukatsu, Hiroshi; Ando, Yoko; Ishigaki, Takeo [Nagoya Univ. (Japan). School of Medicine; Okada, Tamotsu

    1995-02-01

    Eight cases of clinically diagnosed sleep apnea syndrome (SAS) and two normal volunteers were studied with low field MR fluoroscopy in order to monitor the waking and sleeping status of the upper airway. MR fluoroscopy revealed that only the sleeping patients showed occlusions of the upper airway. This technique provided us with useful information about the level, frequency and duration of occlusion in each case. Four of the eight patients demonstrated simple retropalatal occlusion, whereas the other four demonstrated mixed retropalatal and retropalato-retroglossal occlusion. Thus long-time monitoring, which is only possible with MR fluoroscopy, is needed to appreciate the complex nature of the disease. In addition, the comfortable surroundings and low noise level provided by the low field enabled physiological study to be performed without any tranquilizers in most of the patients, which is again only possible with MR fluoroscopy. MR fluoroscopy may become a tool of great clinical value, providing much important information for disease evaluation and treatment selection. (author).

  11. SPSS and SAS procedures for estimating indirect effects in simple mediation models.

    Science.gov (United States)

    Preacher, Kristopher J; Hayes, Andrew F

    2004-11-01

    Researchers often conduct mediation analysis in order to indirectly assess the effect of a proposed cause on some outcome through a proposed mediator. The utility of mediation analysis stems from its ability to go beyond the merely descriptive to a more functional understanding of the relationships among variables. A necessary component of mediation is a statistically and practically significant indirect effect. Although mediation hypotheses are frequently explored in psychological research, formal significance tests of indirect effects are rarely conducted. After a brief overview of mediation, we argue the importance of directly testing the significance of indirect effects and provide SPSS and SAS macros that facilitate estimation of the indirect effect with a normal theory approach and a bootstrap approach to obtaining confidence intervals, as well as the traditional approach advocated by Baron and Kenny (1986). We hope that this discussion and the macros will enhance the frequency of formal mediation tests in the psychology literature. Electronic copies of these macros may be downloaded from the Psychonomic Society's Web archive at www.psychonomic.org/archive/.

  12. [Evaluation of the factorial and metric equivalence of the Sexual Assertiveness Scale (SAS) by sex].

    Science.gov (United States)

    Sierra, Juan Carlos; Santos-Iglesias, Pablo; Vallejo-Medina, Pablo

    2012-05-01

    Sexual assertiveness refers to the ability to initiate sexual activity, refuse unwanted sexual activity, and use contraceptive methods to avoid sexually transmitted diseases, developing healthy sexual behaviors. The Sexual Assertiveness Scale (SAS) assesses these three dimensions. The purpose of this study is to evaluate, using structural equation modeling and differential item functioning, the equivalence of the scale between men and women. Standard scores are also provided. A total of 4,034 participants from 21 Spanish provinces took part in the study. Quota sampling method was used. Results indicate a strict equivalent dimensionality of the Sexual Assertiveness Scale across sexes. One item was flagged by differential item functioning, although it does not affect the scale. Therefore, there is no significant bias in the scale when comparing across sexes. Standard scores show similar Initiation assertiveness scores for men and women, and higher scores on Refusal and Sexually Transmitted Disease Prevention for women. This scale can be used on men and women with sufficient psychometric guarantees.

  13. Cosmic radiation and airline pilots. Exposure patterns of Norwegian pilots flying aircraft not used by SAS

    Energy Technology Data Exchange (ETDEWEB)

    Tveten, U.

    1997-05-01

    The work which is presented in this report is part of a Norwegian epidemiological project, carried out in cooperation between Institutt for Energiteknikk (IFE), the Norwegian Cancer Registry (NCR) and the Norwegian Radiation Protection Authority (NRPA). The project has been partially financed by the Norwegian Research Council. Originating from the Norwegian project, a number of similar projects have been started or are in the planning stage in a number of European countries. The present report lays the ground for estimation of individual exposure histories to cosmic radiation of pilots flying a great diversity of different aircrafts. Aircrafts that appear in the time-tables of the Scandinavian Airline System (SAS) have been treated in an earlier report. The results presented in this report (radiation doserates for the different types of aircrafts in the different years) will, in a later stage of the project be utilized to estimate the individual radiation exposure histories. The major sources of information used as basis for the work in this report is information provided by several active pilots, members of the Pilots Associations, along with calculations performed using US Federal Aviation Administration`s computer code CARI-3N. 2 refs.

  14. SAS-2 observations of the galactic gamma radiation from the Vela region

    Science.gov (United States)

    Thompson, D. J.; Bignami, G. F.; Fichtel, C. E.; Kniffen, D. A.

    1974-01-01

    Data from a scan of the galactic plane by the SAS-2 high energy gamma ray experiment in the region 250 deg l2 290 deg show a statistically-significant excess over the general radiation from the galactic plane for gamma radiation of energy 100 MeV in the region 260 deg l2 270 deg and -7.5 deg b2 0 deg. If the enhanced gamma radiation results from interactions of cosmic rays with galactic matter, as the energy spectrum suggests, it seems reasonable to associate the enhancement with large scale galactic features, such as spiral arm segments in that direction, or with the region surrounding the Vela supernova remnant, with which PSR 0833-45 is associated. If the excess is attributed to cosmic rays released from this supernova interacting with the interstellar matter in that region, then on the order of 3.10 to the 50th power ergs would be released by that supernova in the form of cosmic rays.

  15. Age-related changes in the bone marrow and spleen of SAS/4 mice.

    Science.gov (United States)

    Coggle, J E; Gordon, M Y; Proukakis, C; Bogg, C E

    1975-01-01

    The total number of nucleated cells in the bone marrow of SAS/4 mice increase some twofold between 1 and 24 months of age but when related to body weight remains essentially constant over a wide range of ages. The concentration of CFU-S in femoral marrow is also constant with age and since other bones containing marrow appear, at least in young mice, to have the same CFU-S concentration as the femur it is concluded that the CFU-S compartment size of the whole bone marrow is independent of age when expressed on a body weight basis, In contrast, both the absolute number and the concentration of exogenous CFU-S in the spleen decline markedly in old mice. Smilary there is a decline in the number of endogenous colony-forming cells and the spleens of 24-month-old mice seem virtually devoid of such colonies. Not only were older mice less capable of supporting the growth of endogenous colonies, but their spleens also appear to provide a poorer environment for exogenous colony growth when compared with growth in younger recipient spleens.

  16. SAS 3 observations of two X-ray transient events with precursors

    Science.gov (United States)

    Hoffman, J. A.; Lewin, W. H. G.; Doty, J.; Jernigan, J. G.; Haney, M.; Richardson, J. A.

    1978-01-01

    SAS 3 has observed two unusual fast transient X-ray events from different sources, one lasting about 150 s and one, approximately 1500 s. Both events were preceded by precursor pulses which lasted a few seconds and which rose and fell in less than 0.4 s. The precursors were separated from the 'main' events by several seconds, during which no X-rays were detected. There are similarities between the two main events and X-ray bursts in both their temporal and spectral evolution. The spectra of the main events started out much softer than the spectra of the precursors, became harder as they approached maximum intensity, and softened as they decayed. In the 1500-s event, X-rays with energies greater than 10 keV were delayed by about 80 s compared with 1.5-6-keV X-rays. A blackbody fit to the spectral data of the main event of approximately 1500-s duration gives a maximum temperature of 29 million K and a radius for the emitting region of at least about 9 km (at a distance of 10 kpc); this is similar to the temperature and sizes found for several X-ray burst sources.

  17. Sulfuric acid speleogenesis (SAS) close to the water table: Examples from southern France, Austria, and Sicily

    Science.gov (United States)

    De Waele, Jo; Audra, Philippe; Madonia, Giuliana; Vattano, Marco; Plan, Lukas; D'Angeli, Ilenia M.; Bigot, Jean-Yves; Anoux, Catherine; Nobécourt, Jean-Claude

    2016-01-01

    Caves formed by rising sulfuric waters have been described from all over the world in a wide variety of climate settings, from arid regions to mid-latitude and alpine areas. H2S is generally formed at depth by reduction of sulfates in the presence of hydrocarbons and is transported in solution through the deep aquifers. In tectonically disturbed areas major fractures eventually allow these H2S-bearing fluids to rise to the surface where oxidation processes can become active producing sulfuric acid. This extremely strong acid reacts with the carbonate bedrock creating caves, some of which are among the largest and most spectacular in the world. Production of sulfuric acid mostly occurs at or close to the water table but also in subaerial conditions in moisture films and droplets in the cave environment. These caves are generated at or immediately above the water table, where condensation-corrosion processes are dominant, creating a set of characteristic meso- and micromorphologies. Due to their close connection to the base level, these caves can also precisely record past hydrological and geomorphological settings. Certain authigenic cave minerals, produced during the sulfuric acid speleogenesis (SAS) phase, allow determination of the exact timing of speleogenesis. This paper deals with the morphological, geochemical and mineralogical description of four very typical sulfuric acid water table caves in Europe: the Grotte du Chat in the southern French Alps, the Acqua Fitusa Cave in Sicily (Italy), and the Bad Deutsch Altenburg and Kraushöhle caves in Austria.

  18. SAS-2 gamma-ray observations of PSR 1747-46

    Science.gov (United States)

    Thompson, D. J.; Fichtel, C. E.; Kniffen, D. A.; Lamb, R. C.; Oegelman, H. B.

    1976-01-01

    Observations with the SAS-2 high energy ( 35 MeV) gamma-ray telescope show evidence of gamma-ray emission from the radio pulsar PSR 1747-46. When the arrival times of gamma-rays from the region of the pulsar were converted to pulsar phases using the radio period and period derivative, a single peak was found in the phase plot, with a Poisson probability of occurring by chance of .00008. Independently, the time-averaged data for the PSR 1747-46 region show an enhancement over the surrounding region of the sky at the same galactic latitude, with a Poisson probability of chance occurrence of less than .008. The probability that these results are chance is the product of these two probabilities times the number of radio pulsars examined (73). This overall probability is sufficiently small (.00005) to suggest an identification of a new gamma-ray pulsar. In the gamma-ray pulsar plot, the peak falls 0.16 + or - 0.03 period after the radio pulsar peak. This phase shift is, within uncertainties, the same as that observed between the single radio peak and the first of the two gamma-ray peaks seen in the phase plot for PSR-0833-45 (the Vela pulsar).

  19. Activation des puits : critères de sélection des procédés Activation of Wells: Criteria for Process Selection

    Directory of Open Access Journals (Sweden)

    Corteville J.

    2006-11-01

    Full Text Available Il existe quatre modes principaux de pompage des bruts pétroliers en fond de puits qui comportent le transfert de l'énergie nécessaire de la surface vers le fond de manière mécanique, électrique, pneumatique ou hydraulique. Aussi l'équipement d'un champ pose-t-il un problème difficile de choix parmi ces procédés et leurs diverses variantes. Cet article comporte d'abord une analyse résumée des techniques actuelles en ce domaine. Il décrit ensuite une méthode générale de sélection des procédés permettant d'optimiser les équipements. Cette méthode est basée sur un système expert et un modèle de calcul des rendements énergétiques et des coûts de revient. Un exemple de résultats de calculs effectués sur un gisement de type classique est présenté. Ces résultats permettent de comparer de manière quantitative les principaux procédés. There are four main methods for the downhole pumping of crude oil that involve the transfer of the necessary power from the surface to downhole: mechanical, electric, pneumatic, hydraulic. Likewise, the equipment of a field raises a difficult problem of choosing among these processes and their different variants. This article first makes a review analysis of techniques now used in this area. It then describes a general method for selecting processes with a view to optimizing equipment. This method is based on an expert system and a model for computing energy efficiencies and cost prices. An example of computing results is given for a conventional type of field. These results can be used to make a quantitative comparison of the leading processes.

  20. The School Anxiety Scale-Teacher Report (SAS-TR: translation and psychometric properties of the Iranian version

    Directory of Open Access Journals (Sweden)

    Hajiamini Zahra

    2012-07-01

    Full Text Available Abstract Background The School Anxiety Scale-Teacher Report (SAS-TR was designed to assess anxiety in children at school. The SAS-TR is a proxy rated measure and could assess social anxiety, generalized anxiety and also gives a total anxiety score. This study aimed to translate and validate the SAS-TR in Iran. Methods The translation and cultural adaptation of the original questionnaire were carried out in accordance with the published guidelines. A sample of students participated in the study. Reliability was estimated using internal consistency and test-retest analysis. Validity was assessed using content validity. The factor structure of the questionnaire was extracted by performing both exploratory and confirmatory factor analyses. Results In all 200 elementary students aged 6 to 10 years were studied. Considering the recommended cut-off values, overall the prevalence of high anxiety condition in elementary students was found to be 21 %. Cronbach's alpha coefficient for the Iranian SAS-TR was 0.92 and intraclass correlation coefficient (ICC was found to be 0.81. The principal component analysis indicated a two-factor structure for the questionnaire (generalized and social anxiety that jointly accounted for 55.3 % of variances observed. The confirmatory factory analysis also indicated a good fit to the data for the two-latent structure of the questionnaire. Conclusion In general the findings suggest that the Iranian version of SAS-TR has satisfactory reliability, and validity for measuring anxiety in 6 to 10 years old children in Iran. It is simple and easy to use and now can be applied in future studies.

  1. Comparison of ArcGIS and SAS Geostatistical Analyst to Estimate Population-Weighted Monthly Temperature for US Counties.

    Science.gov (United States)

    Xiaopeng, Q I; Liang, Wei; Barker, Laurie; Lekiachvili, Akaki; Xingyou, Zhang

    Temperature changes are known to have significant impacts on human health. Accurate estimates of population-weighted average monthly air temperature for US counties are needed to evaluate temperature's association with health behaviours and disease, which are sampled or reported at the county level and measured on a monthly-or 30-day-basis. Most reported temperature estimates were calculated using ArcGIS, relatively few used SAS. We compared the performance of geostatistical models to estimate population-weighted average temperature in each month for counties in 48 states using ArcGIS v9.3 and SAS v 9.2 on a CITGO platform. Monthly average temperature for Jan-Dec 2007 and elevation from 5435 weather stations were used to estimate the temperature at county population centroids. County estimates were produced with elevation as a covariate. Performance of models was assessed by comparing adjusted R(2), mean squared error, root mean squared error, and processing time. Prediction accuracy for split validation was above 90% for 11 months in ArcGIS and all 12 months in SAS. Cokriging in SAS achieved higher prediction accuracy and lower estimation bias as compared to cokriging in ArcGIS. County-level estimates produced by both packages were positively correlated (adjusted R(2) range=0.95 to 0.99); accuracy and precision improved with elevation as a covariate. Both methods from ArcGIS and SAS are reliable for U.S. county-level temperature estimates; However, ArcGIS's merits in spatial data pre-processing and processing time may be important considerations for software selection, especially for multi-year or multi-state projects.

  2. Étude d’un procédé de mise en forme de matières naturelles lignocellulosiques par thermocompression uniaxiale haute pression

    OpenAIRE

    2015-01-01

    L’objet de cette thèse est l’étude d’un nouveau procédé de fabrication d’agromatériaux : le moulage par thermocompression uniaxiale haute pression de matières végétales, sans prétraitement et sans ajout de liant. Le premier chapitre dresse l’état de l’art des matériaux lignocellulosiques « auto-liés », tels que définis dans le domaine des panneaux de fibres. Sont étudiés : l’influence des conditions opératoires pour servir de référence malgré une pression de moulage inférieure à celle envisag...

  3. The neo-epitope specific PRO-C3 ELISA measures true formation of type III collagen associated with liver and muscle parameters

    DEFF Research Database (Denmark)

    Nielsen, Mette J; Nedergaard, Anders F; Sun, Shu;

    2013-01-01

    AIM: The present study describes the assessment of true formation of type III collagen in different pathologies using a neo-epitope specific competitive Enzyme-linked immunosorbent assay (ELISA) towards the N-terminal propeptide of type III collagen (PRO-C3). METHODS: The monoclonal antibody...... was raised against the N-protease mediated cleavage site of the N-terminal propeptide of type III collagen and a competitive ELISA was developed using the selected antibody. The assay was evaluated in relation to neo-epitope specificity, technical performance, and as a marker for liver fibrosis and muscle...... mass using the rat carbon tetrachloride (CCl4) model and a study of immobilization induced muscle loss in humans, respectively. RESULTS: The ELISA was neo-epitope specific, technically stable and can be assessed in serum and plasma samples. In the CCl4 liver fibrosis model it was observed that serum...

  4. Modélisation multi-physique couplée d'un procédé de traitement thermique par induction

    OpenAIRE

    Cardinaux, David; Bay, François; Chastel, Yvan; Feraille, Julien

    2009-01-01

    http://hdl.handle.net/2042/36901; International audience; L'étude s'applique à la trempe après chauffage par induction localisé d'une tôle emboutie. Le procédé génère des distorsions dans la structure qui sont à maîtriser. Un outil de calcul numérique tenant compte des couplages multi-physiques entre électromagnétisme, thermique, mécanique et métallurgie est alors nécessaire. La création d'un tel outil utilisant la méthode des éléments finis est le but de ce travail.

  5. La pràctica espiritual del ioga incorporada al procés de socialització primària.

    OpenAIRE

    Roca Samon, Núria

    2016-01-01

    L'estudi tracta sobre el ioga entès com una pràctica espiritual, la qual és incorporada per algunes famílies dins del procés de socialització primària, i com aquest fenomen social és interpretat com a mecanisme de reencantament del món, concepte emprat pel sociòleg francès Michel Maffesoli. Metodològicament, es caracteritza per ser una recerca qualitativa la qual s'emmarca al barri de Gràcia de Barcelona, on s'ha realitzat observació participant a diferents centres de ioga especialitzats en i...

  6. Développement d’un procédé biotechnologique de production de molécules à note verte à partir de feuilles de betterave

    OpenAIRE

    Gigot, Cédric

    2011-01-01

    La grande richesse des feuilles de betterave en 13-HPL (entre 10 et 12 UE1/g de poids frais), une enzyme produisant le (3Z)-hexénol, le (2E)-hexénal et le n-hexanal, fait de ce substrat un candidat potentiel pour le développement d’un procédé biotechnologique de production d’arômes alimentaires. Maillon essentiel du système de défense des plantes, l’enzyme 13-HPL est inductible par des stimuli externes et son expression dépend de l’âge et de l’état physiologique de la plante. Au cours de c...

  7. Le Procès de Tôkyô, l’empereur et la question du Yasukuni The Tokyo trial, the emperor and the Yasukuni shrine

    OpenAIRE

    Tetsuya Takahashi

    2010-01-01

    Au Japon, toute une partie de la classe politique conservatrice persiste à refuser les conclusions du procès de Tôkyô, considérant celui-ci comme une justice « orchestrée par les vainqueurs ». Ce faisant, les partisans de cette thèse se trouvent dans une contradiction puisque l’empereur Hirohito lui-même, qui avait exprimé sa gratitude auprès des forces d’occupation américaines pour l’avoir épargné, en avait de facto admis les conclusions. Ce paradoxe pour le camp conservateur est aggravé par...

  8. Procédé AD-OX d'élimination de polluants organiques non biodégradables (par adsorption puis oxydation catalytique)

    OpenAIRE

    Manole Creanga, Carmen

    2007-01-01

    Vers un nouveau procédé séquentiel AD-OX (Adsorption–Oxydation) de traitement d'eau par charbon actif nous avons examiné les deux étapes séparément, pour des polluants peu biodégradables (phénol et acide 4-hydroxybenzoïque (4AHB), seuls et en mélange). Les isothermes d'adsorption sur charbon actif neuf, puis après oxydation catalytique, ont été obtenues à température ambiante et à 150°C. Les mélanges binaires ont aussi été testés montrant l'adsorption très préférentielle du 4AHB. L'oxydation...

  9. PRO-C3-levels in patients with HIV/HCV-Co-infection reflect fibrosis stage and degree of portal hypertension

    DEFF Research Database (Denmark)

    Jansen, Christian; Leeming, Diana J; Mandorfer, Mattias

    2014-01-01

    BACKGROUND: Liver-related deaths represent the leading cause of mortality among patients with HIV/HCV-co-infection, and are mainly related to complications of fibrosis and portal hypertension. In this study, we aimed to evaluate the structural changes by the assessment of extracellular matrix (ECM......) derived degradation fragments in peripheral blood as biomarkers for fibrosis and portal hypertension in patients with HIV/HCV co-infection. METHODS: Fifty-eight patients (67% male, mean age: 36.5 years) with HIV/HCV-co-infection were included in the study. Hepatic venous pressure gradient (HVPG......4M and C5M levels were higher in patients with portal hypertension (HVPG>5 mmHg). CONCLUSION: PRO-C3 levels reflect liver injury, stage of liver fibrosis and degree of portal hypertension in HIV/HCV-co-infected patients. Furthermore, C4M and C5M were associated with increased portal pressure...

  10. Analyse statistique de l'assemblage acier/aluminium réalisé par le procédé de soudage MIG-CMT

    OpenAIRE

    Mezrag, Bachir; Benachour, Mustapha; Deschaux Beaume, Frédéric

    2014-01-01

    International audience; La dépendance vis-à-vis des paramètres de soudage de la géométrie de l'assemblage hétérogène acier/aluminium réalisé par le procédé MIG-CMT dans une configuration à clin est étudiée à travers un plan d'expérience. Les paramètres choisis comme facteurs d'influence sont la puissance de soudage, la distance entre la torche et la pièce ou "stick-out", le débit de gaz et la vitesse de soudage, tandis que les caractéristiques géométriques sélectionnées comme fonctions object...

  11. PROC, PROCR, and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study

    Science.gov (United States)

    Reiner, Alexander P.; Carty, Cara L.; Jenny, Nancy S.; Nievergelt, Caroline; Cushman, Mary; Stearns-Kurosawa, Deborah J.; Kurosawa, Shinichiro; Kuller, Lewis H.; Lange, Leslie A.

    2010-01-01

    Background & Objectives Genes encoding protein C anticoagulant pathways are candidates for athero-thrombotic and other aging-related disorders. Methods Using a tagSNP approach, and data from the Cardiovascular Health Study (CHS), we assessed associations of common polymorphisms of PROC, PROS1, and PROCR with (1) plasma protein C, soluble protein C receptor (sEPCR), and protein S levels measured in a sub-sample of 336 participants at study entry; (2) risk of incident clinical outcomes (coronary heart disease or CHD, stroke, and mortality) in 4,547 participants during follow-up. Secondarily, we explored associations between plasma protein C, S, and sEPCR levels and other candidate genes involved in thrombosis, inflammation, and aging. Results The PROCR Ser219Gly polymorphism (rs867186) was strongly associated with higher sEPCR levels, explaining 75% of the phenotypic variation. The Ser219Gly variant was also associated with higher levels of circulating protein C antigen. An IL10 polymorphism was associated with higher free protein S levels. The minor alleles of PROC rs2069901 and PROS1 rs4857343 were weakly associated with lower protein C and free protein S levels, respectively. There was no association between PROCR Ser219Gly and risk of CHD, stroke, or mortality. The minor allele of another common PROCR tagSNP, rs2069948, was associated with lymphoid PROCR mRNA expression and with increased risk of incident stroke and all-cause mortality, and decreased healthy survival during follow-up. Conclusions A common PROCR variant may be associated with decreased healthy survival in older adults. Additional studies are warranted to establish the role of PROCR variants in ischemic and aging-related disorders. PMID:18680534

  12. Procédé IFP de proction de protéines ex-paraffines Ifp Process for Protein Production Ex Praffins

    Directory of Open Access Journals (Sweden)

    Ballerini D.

    2006-11-01

    Full Text Available Cet article présente les grandes lignes du procédé ,IFP de production de protéines d'organismes unicellulaires, procédé réalisé avec un nouveau type de réacteur (jet-liquide Vogelbusch. Le microorganisme sélectionné est une souche de levure Candida tropicalis IFP 10, le substrat carboné employé étant une coupe de n-paraffines purifiées C18-C18. Avec le réacteur Vogelbusch, la fermentation est réalisée en un seul étage avec un taux d'hydrocarbures résiduels inférieur à 0,5 %o et une productivité élevée de l'ordre de 4 g " I-1 " h-1. Enfin sont résumés les résultats des tests toxicologiques et nutritionnels effectués sur la poudre de levures sèches. This article describes the leading aspects of the IFP process for producing singlecell proteins by means of a new type of reactor (Vogelbusch liquid jet. The microoganism chosen is a strain of Candida tropicalis IFP 10 yeast, while the carbon-containing substrate utilized is a C13-c18 cut of purified n-paraffins. With the Vogelbusch reactor, fermentation is done in a single stage with a residual hydrocarbon concentration lower than 0.5 %o and a high productivity of about 4 g-I-1- h r1. The results of toxicological and nutritional tests performed with dry yeast powder are summed up.

  13. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT, PERFORMANCE TEST RESULTS FOR THE A AND A ENVIRONMENTAL SEALS' SEAL ASSIST SYSTEM (SAS), PHASE I--TECHNOLOGY VERIFICATION REPORT

    Science.gov (United States)

    The report presents results of tests determining the efficacy of A&A Environmental Seals, Inc's Seal Assist System (SAS) in preventing natural gas compressor station's compressor rod packing leaks from escaping into the atmosphere. The SAS consists of an Emission Containment Glan...

  14. 效应量在外语研究独立样本T检验中的应用及意义%Application and Significance of Effect Sizes of Independent Sample T-test in Foreign Language Research

    Institute of Scientific and Technical Information of China (English)

    秦学锋; 杨东益; 杨东英

    2014-01-01

    The level of statistical significance doesn’t mean the magnitude of practical significance in experimental research. Effect sizes can be a useful adjunct to evaluate the practical significance of research outcomes. By computing and analyzing the effect sizes from 33 independent samples T-test results, this thesis argues that measures of effect sizes have a legitimate place in the advancement of current foreign language research, and that meta-analysis is conducted based on effect sizes.%统计上的显著意义不能等同于实验结果的实际意义显著。效应量可来辅助评价研究结果的实际意义大小。通过对33个独立样本T检验研究效应量的计算分析,建议外语研究者重视对效应量的研究与运用,并进一步开展元分析研究。

  15. RHESSI/SAS Observations of the Optical Solar Limb Over More Than 14 Years

    Science.gov (United States)

    Fivian, Martin; Hudson, Hugh S.; Krucker, Sam

    2016-05-01

    The Solar Aspect System (SAS) of the RHESSI satellite measures the optical solar limb with a cadence typically set at 100 samples/s.RHESSI has observed the Sun continuously since its launch in early 2002, and we have acquired a unique data set ranging over more than a full 11-year solar cycle and consisting of about 4x10^10 single data points.The optics has a point spread of about 4.5 arcsec FWHM imaging the red continuum onto three linear CCD sensors with a pixel resolution of 1.7 arcsec.However, careful study of systematics, masking of contaminated data, and accumulation of data over appropriate time intervals has led to measurementswith sub-milli arcsec accuracy.Analyzing data for an initial period in 2004, these measurements have led to the most accurate oblateness measurement to date, 8.01+-0.14 milli arcsec (Fivian et al., 2008), a value consistent with models predicting an oblateness from surface rotation.An excess oblateness term can be attributed to magnetic elements possibly located in the enhanced network.We also study photometric properties of our data. Previous observations of latitude-dependent brightness variations at the limb had suggested the presence of a polar temperature excess as large as 1.5 K.The RHESSI observations, made with a rotating telescope in space, have great advantages in the rejection of systematic errors in the very precise photometry required for such an observation.Our measurements of latitude-dependent brightness variations at the limb lead to a quadrupolar term (a pole-to-equator temperature variation) of the order of 0.1 K, an order of magnitude smaller than previously reported.We present the analysis of these unique data, an overview of some results and we report on our progress as we apply our developed analysis method to the whole 14 years of data.

  16. Procédé de fabrication de Gaz Naturel de Synthèse par couplage d'une méthanation avec une électrolyse de vapeur d'eau à haute température

    OpenAIRE

    De Saint Jean, Myriam; Lacroix, Vincent; Baurens, Pierre; Bouallou, Chakib

    2013-01-01

    National audience; Le procédé présenté ici est un procédé de type Power-to-Gas dont l'objectif est de produire un gaz de synthèse injectable sur les réseaux de gaz naturel, en couplant une électrolyse de vapeur d'eau à haute température à cellule à oxyde solide (Solid Oxide Electrolysis Cell) et une hydrogénation de CO2 afin de produire du méthane, composant majeur du gaz naturel de synthèse. La simulation de ce procédé est réalisée avec le logiciel de simulation ProSim Plus 3® et des modèles...

  17. Cdk1 Phosphorylates Drosophila Sas-4 to Recruit Polo to Daughter Centrioles and Convert Them to Centrosomes.

    Science.gov (United States)

    Novak, Zsofia A; Wainman, Alan; Gartenmann, Lisa; Raff, Jordan W

    2016-06-20

    Centrosomes and cilia are organized by a centriole pair comprising an older mother and a younger daughter. Centriole numbers are tightly regulated, and daughter centrioles (which assemble in S phase) cannot themselves duplicate or organize centrosomes until they have passed through mitosis. It is unclear how this mitotic "centriole conversion" is regulated, but it requires Plk1/Polo kinase. Here we show that in flies, Cdk1 phosphorylates the conserved centriole protein Sas-4 during mitosis. This creates a Polo-docking site that helps recruit Polo to daughter centrioles and is required for the subsequent recruitment of Asterless (Asl), a protein essential for centriole duplication and mitotic centrosome assembly. Point mutations in Sas-4 that prevent Cdk1 phosphorylation or Polo docking do not block centriole disengagement during mitosis, but block efficient centriole conversion and lead to embryonic lethality. These observations can explain why daughter centrioles have to pass through mitosis before they can duplicate and organize a centrosome.

  18. An essential role of the basal body protein SAS-6 in Plasmodium male gamete development and malaria transmission

    OpenAIRE

    Marques, SR; Ramakrishnan, C; Carzaniga, R.; Blagborough, AM; Delves, MJ; Talman, AM; Sinden, RE

    2014-01-01

    Gametocytes are the sole P lasmodium parasite stages that infect mosquitoes; therefore development of functional gametes is required for malaria transmission. Flagellum assembly of the P lasmodium male gamete differs from that of most other eukaryotes in that it is intracytoplasmic but retains a key conserved feature: axonemes assemble from basal bodies. The centriole/basal body protein SAS-6 normally regulates assembly and duplication of these organelles and its depletion causes severe flage...

  19. Annotated Computer Output for Illustrative Examples of Clustering Using the Mixture Method and Two Comparable Methods from SAS.

    Science.gov (United States)

    1987-06-26

    BUREAU OF STANDAR-S1963-A Nw BOM -ILE COPY -. 4eo .?3sa.9"-,,A WIN* MAT HEMATICAL SCIENCES _*INSTITUTE AD-A184 687 DTICS!ELECTE ANNOTATED COMPUTER OUTPUT...intoduction to the use of mixture models in clustering. Cornell University Biometrics Unit Technical Report BU-920-M and Mathematical Sciences Institute...mixture method and two comparable methods from SAS. Cornell University Biometrics Unit Technical Report BU-921-M and Mathematical Sciences Institute

  20. Plan de negocios para la creación de la empresa Agua Vida S.A.S.

    OpenAIRE

    Del Rio Caicedo, Sergio Antonio; Rosero Morán, Daniel Hernando

    2013-01-01

    El trabajo contiene el plan de negocios para crear la empresa Agua Vida SAS., donde sus productos son la purificación y comercialización de agua potable en universidades mediante dispensadores; el documento presenta el plan de mercadeo y a su vez pretende despertar en los estudiantes conciencia ambiental para que carguen un termo y paguen para que este sea llenado en los dispensadores de las instituciones educativas

  1. Exergy Analysis and Exergo-Economic Optimization of Industrial Processes Optimisation des procédés industriels par analyse exergétique et exergo-économique

    Directory of Open Access Journals (Sweden)

    Le Goff P.

    2006-11-01

    Full Text Available The overall evaluation of a process can be made by exergy accounting or by financial accounting. In all cases, a process can be optimized by determining the best compromise between the various input fluxes. L'évaluation globale d'un procédé peut être faite soit au moyen d'un bilan exergétique, soit par l'intermédiaire d'un bilan économique. Dans tous les cas, un procédé peut être optimisé en déterminant le meilleur compromis entre les différents flux mis en jeu.

  2. Cosmic radiation and airline pilots. Exposure patterns of Norwegian SAS-pilots 1960 to 1994. Revised Version

    Energy Technology Data Exchange (ETDEWEB)

    Tveten, U

    1999-02-01

    The present report is a revised version of an earlier report (IFE/KR/E-96/008). The revision has been carried out since a completely new version of the computational tool has recently been released. All calculations have been redone. The work which is presented in this report is part of a Norwegian epidemiological project, carried out in cooperation between Institute for Energy Technology (IFE), the Norwegian Cancer Registry (NCR) and the Norwegian Radiation Protection Authority (NRPA). Originating from the Norwegian project, a number of similar projects have been started in a number of European countries. The present report lays the ground for estimation of individual exposure histories to cosmic radiation of pilots employed by the the Scandinavian Airlines System (SAS). The result presented in this report (radiation dose rates for the different types of aircraft in the different years) were calculated with the most recent computer program for this purpose, the CARI-5E from the United States Civil Aviation Authority. The other major sources of information used as basis for this work is the collection of old SAS time tables found the the SAS Museum at Fornebu Airport in Oslo, and information provided by members of the Pilots Association in Norway.

  3. Tutorial: Survival Estimation for Cox Regression Models with Time-Varying Coe?cients Using SAS and R

    Directory of Open Access Journals (Sweden)

    Laine Thomas

    2014-10-01

    Full Text Available Survival estimates are an essential compliment to multivariable regression models for time-to-event data, both for prediction and illustration of covariate effects. They are easily obtained under the Cox proportional-hazards model. In populations defined by an initial, acute event, like myocardial infarction, or in studies with long-term followup, the proportional-hazards assumption of constant hazard ratios is frequently violated. One alternative is to fit an interaction between covariates and a prespecified function of time, implemented as a time-dependent covariate. This effectively creates a time-varying coefficient that is easily estimated in software such as SAS and R. However, the usual programming statements for survival estimation are not directly applicable. Unique data manipulation and syntax is required, but is not well documented for either software. This paper offers a tutorial in survival estimation for the time-varying coefficient model, implemented in SAS and R. We provide a macro coxtvc to facilitate estimation in SAS where the current functionality is more limited. The macro is validated in simulated data and illustrated in an application.

  4. Cucurbitacin E as inducer of cell death and apoptosis in human oral squamous cell carcinoma cell line SAS.

    Science.gov (United States)

    Hung, Chao-Ming; Chang, Chi-Chang; Lin, Chen-Wei; Ko, Shun-Yao; Hsu, Yi-Chiang

    2013-08-20

    Human oral squamous cell carcinoma (OSCC) is a common form of malignant cancer, for which radiotherapy or chemotherapy are the main treatment methods. Cucurbitacin E (CuE) is a natural compound previously shown to be an antifeedant as well as a potent chemopreventive agent against several types of cancer. The present study investigates anti-proliferation (using MTT assay, CuE demonstrated cytotoxic activity against SAS cell with IC50 values at 3.69 µM) and induced apoptosis of human oral squamous cell carcinoma SAS cells after 24 h treatment with CuE. Mitochondrial membrane potential (MMP) and caspase activity were studied and our results indicate that CuE inhibits cell proliferation as well as the activation of apoptois in SAS cells. Both effects increased in proportion to the dosage of CuE and apoptosis was induced via mitochondria- and caspase-dependent pathways. CuE can induce cell death by a mechanism that is not dependent on apoptosis induction, and thus represents a promising anticancer agent for prevention and treatment of OSCC.

  5. Le Procès de Tôkyô, l’empereur et la question du Yasukuni The Tokyo trial, the emperor and the Yasukuni shrine

    Directory of Open Access Journals (Sweden)

    Tetsuya Takahashi

    2010-07-01

    Full Text Available Au Japon, toute une partie de la classe politique conservatrice persiste à refuser les conclusions du procès de Tôkyô, considérant celui-ci comme une justice « orchestrée par les vainqueurs ». Ce faisant, les partisans de cette thèse se trouvent dans une contradiction puisque l’empereur Hirohito lui-même, qui avait exprimé sa gratitude auprès des forces d’occupation américaines pour l’avoir épargné, en avait de facto admis les conclusions. Ce paradoxe pour le camp conservateur est aggravé par le fait que l’empereur a cessé de se rendre au sanctuaire Yasukuni à partir du moment où les mânes de quatorze haut responsables condamnés comme criminels de guerre lors du procès de Tôkyô y furent transférés sans son accord. Ces contradictions internes à la droite irrédentiste japonaise invite ainsi à envisager le procès de Tôkyô sous un autre jour. Loin d’être une simple « justice de vainqueur », la stratégie américaine fut éminemment bénéfique pour la droite conservatrice : Hirohito n’étant pas traduit en justice, il devenait possible de lui conférer une fonction symbolique par l’article I de la nouvelle Constitution de 1946, ce qui permit à la droite conservatrice de sauver le système impérial et d’assurer une continuité entre l’avant et l’après-guerre.In Japan, a part of the conservative political class continues to deny the conclusions of the Tokyo trial, as a justice “of the victors”. But the proponents of this theory face a contradiction since the Emperor Hirohito himself expressed his gratitude to the American occupation authority (SCAP for not condemning him. Hirohito therefore admitted the conclusions of the trial. The paradox goes even further as the conservative leaders publicize their visit to Yasukuni shrine although the Emperor himself ceased to visit the shrine after top leaders convicted as war criminals at the Tokyo Trial were transferred to the shrine without his

  6. Mexican Seismic Alert System's SAS-I algorithm review considering strong earthquakes felt in Mexico City since 1985

    Science.gov (United States)

    Cuellar Martinez, A.; Espinosa Aranda, J.; Suarez, G.; Ibarrola Alvarez, G.; Ramos Perez, S.; Camarillo Barranco, L.

    2013-05-01

    The Seismic Alert System of Mexico (SASMEX) uses three algorithms for alert activation that involve the distance between the seismic sensing field station (FS) and the city to be alerted; and the forecast for earthquake early warning activation in the cities integrated to the system, for example in Mexico City, the earthquakes occurred with the highest accelerations, were originated in the Pacific Ocean coast, whose distance this seismic region and the city, favors the use of algorithm called Algorithm SAS-I. This algorithm, without significant changes since its beginning in 1991, employs the data that generate one or more FS during P wave detection until S wave detection plus a period equal to the time employed to detect these phases; that is the double S-P time, called 2*(S-P). In this interval, the algorithm performs an integration process of quadratic samples from FS which uses a triaxial accelerometer to get two parameters: amplitude and growth rate measured until 2*(S-P) time. The parameters in SAS-I are used in a Magnitude classifier model, which was made from Guerrero Coast earthquakes time series, with reference to Mb magnitude mainly. This algorithm activates a Public or Preventive Alert if the model predicts whether Strong or Moderate earthquake. The SAS-I algorithm has been operating for over 23 years in the subduction zone of the Pacific Coast of Mexico, initially in Guerrero and followed by Oaxaca; and since March 2012 in the seismic region of Pacific covering the coasts among Jalisco, Colima, Michoacan, Guerrero and Oaxaca, where this algorithm has issued 16 Public Alert and 62 Preventive Alerts to the Mexico City where its soil conditions increase damages by earthquake such as the occurred in September 1985. This work shows the review of the SAS-I algorithm and possible alerts that it could generate from major earthquakes recordings detected by FS or seismometers near the earthquakes, coming from Pacific Ocean Coast whose have been felt in Mexico

  7. Simulació d'un procés industrial de cristallització de clorur de sodi (NaCl i aplicacions

    Directory of Open Access Journals (Sweden)

    Josefina Renedo Omaechevarría

    2014-12-01

    Full Text Available La cristal·lització a partir de dissolucions és important industrialment  donada la gran varietat de substàncies que es comercialitzen  cristal·litzades. Per millorar el procés  d’ensenyament-aprenentatge d’aquesta “Operació Bàsica”, en aquest treball, realitzat com a Treball de Fi de Carrera de la titulació  d’ Enginyeria Química, s’ha  desenvolupat un programa de simulació d’una cristal·lització industrial de NaCl.  L’objectiu ha sigut manejar  eines de càlcul  per simular  i optimitzar una cristal·lització, la qual cosa permet conèixer més profundament el procés de la cristal·lització i la utilització de les eines de càlcul, és a dir, utilitzar simultàniament els coneixements adquirits en les assignatures de Operacions amb Sòlid  i la de Simulació i Optimització de Processos. L’objectiu últim de l’ús d’aquest programa de simulació és que els estudiants de l’assignatura optativa Operacions  amb Sòlids del Grau en Enginyeria Química puguin fer servir aquest recurs a l’aula. Amb el programa utilitzat, en llenguatge Fortran, obtenim, d’una manera ràpida i eficaç, la velocitat de creixement dels cristalls G i la velocitat de nucleació B. Un cop calculats els valors de G i B, es pot programar una cristal·lització per obtenir  la distribució de tamany de cristall (DTC desitjat. Per últim s´han determinat els valors dels paràmetres cinètiques de B0.

  8. Tetrandrine induces cell death in SAS human oral cancer cells through caspase activation-dependent apoptosis and LC3-I and LC3-II activation-dependent autophagy.

    Science.gov (United States)

    Huang, An-Cheng; Lien, Jin-Cherng; Lin, Meng-Wei; Yang, Jai-Sing; Wu, Ping-Ping; Chang, Shu-Jen; Lai, Tung-Yuan

    2013-08-01

    Numerous studies have demonstrated that autophagy is associated with cancer development. Thus, agents to induce autophagy could be employed in some cases for the treatment of cancer. Our results showed that tetrandrine significantly decreased the viability of SAS cells in a concentration- and time-dependent manner. Tetrandrine induced nuclear condensation, demonstrated by DAPI staining. The early events in apoptosis analysed by Annexin V/PI staining indicated that the percentage of cells staining positive for Annexin V was slightly increased in SAS cells with tetrandrine treatment but was much lower following bafilomycin A1 pre-treatment. Tetrandrine caused AVO and MDC induction in SAS cells in a concentration-dependent manner by fluorescence microscopy. Tetrandrine also caused LC-3 expression in SAS cells in a time-dependent manner. Our results show that tetrandrine treatment induced the levels of cleaved caspase-3 in a concentration- and time-dependent manner. Tetrandrine treatment induced the levels of LC-3 II, Atg-5, beclin-1, p-S6, p-ULK, p-mTOR, p-Akt (S473) and raptor. Tetrandrine decreased cell viability, but bafilomycin A1, 3-MA, chloroquine and NAC protected tetrandrine-treated SAS cells against decrease of cell viability. Atg-5, beclin-1 siRNA decreased tetrandrine-induced cleaved caspase-3 and cleaved PARP in SAS cells and protected tetrandrine-treated SAS cells against decrease in cell viability. Chloroquine, NAC and bafilomycin A1 also decreased tetrandrine-induced cleaved caspase-3 and cleaved PARP in SAS cells. Our results indicate the tetrandrine induces apoptosis and autophagy of SAS human cancer cells via caspase-dependent and LC3-I and LC3-II‑dependent pathways.

  9. LSI的半高SAS RAID适配器满足了DSA环境下成本和空间的需求

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    LSI Logic公司近日宣布推出业内首批半高(low-profile.LP)SAS RAID存储适配器。新的MegaRAID SAS 8308ELP和SAS 8344ELP是具有8个SAS端口的PCI Express接口适配器,应用于需要使用3Gb/sSAS和/或SATA Ⅱ驱动器的服务器和工作站环境。

  10. Riik võib lüüa SAS-i esmaspäevaks Estonian Airi omanikeringist välja / Erik Müürsepp, Mikk Salu

    Index Scriptorium Estoniae

    Müürsepp, Erik

    2008-01-01

    SAS osaleb Estonian Airþile lisakapitali eraldamises ainult juhul, kui Eesti riik müüb oma osaluses lennukompaniis SAS-ile. Peaminister Andrus Ansipi ning majandus- ja kommunikatsiooniminister Juhan Partsi seisukoht

  11. Novel acridine-based N-acyl-homoserine lactone analogs induce endoreduplication in the human oral squamous carcinoma cell line SAS.

    Science.gov (United States)

    Chai, Hongbo; Hazawa, Masaharu; Hosokawa, Yoichiro; Igarashi, Jun; Suga, Hiroaki; Kashiwakura, Ikuo

    2012-01-01

    The cytotoxicity of novel acridine-based N-acyl-homoserine lactone (AHL) analogs was investigated on the human oral squamous carcinoma cell line SAS. One analog induced G2/M phase arrest at 5.3-10.6 µM and induced polyploidy at a higher dose (21.2 µM). Importantly, treatment of SAS cells with a combination of the AHL analog and the Jun N-terminal kinase (JNK) inhibitor, SP600125, prevented mitosis and induced polyploidy. The AHL analog synergized with X-irradiation to inhibit clonogenic survival of SAS cells; however, its radiosensitizing effects were relative to not X-irradiation-induced apoptosis but mitotic failure following enhanced expression of Aurora A and B. These results suggest that the active AHL analog showed growth-suppressive and radiosensitizing effects, which involve polyploidy followed by G2/M accumulation and atypical cell death in the SAS cell line.

  12. TD-LTE Test System Anite SAS Based on Anite 9000%基于AniteSAS的TD-LTE IOT测试系统开发

    Institute of Scientific and Technical Information of China (English)

    康亮; 李传峰; 秦方民; 崔斌

    2012-01-01

    this article makes an all-around introduction to SAS, the TD-LTE Test system based on Anite 9000. Firstly, the necessity and the contents of SAS Test system is introduced. Then, how to realize TD-LTE test in SAS system is presented detailedly. Finally, the advantage of SAS system is analyzed.%对基于Anite9000的SAS测试系统进行了全面的介绍。首先介绍了SAS测试的必要陛和基本内容,接着阐述了如何使用SAS测试系统实现TD—LTE的测试。最后对SAS的优点进行飞龠舐。

  13. The Music Therapy Session Assessment Scale (MT-SAS): Validation of a new tool for music therapy process evaluation.

    Science.gov (United States)

    Raglio, Alfredo; Gnesi, Marco; Monti, Maria Cristina; Oasi, Osmano; Gianotti, Marta; Attardo, Lapo; Gontero, Giulia; Morotti, Lara; Boffelli, Sara; Imbriani, Chiara; Montomoli, Cristina; Imbriani, Marcello

    2017-08-25

    Music therapy (MT) interventions are aimed at creating and developing a relationship between patient and therapist. However, there is a lack of validated observational instruments to consistently evaluate the MT process. The purpose of this study was the validation of Music Therapy Session Assessment Scale (MT-SAS), designed to assess the relationship between therapist and patient during active MT sessions. Videotapes of a single 30-min session per patient were considered. A pilot study on the videotapes of 10 patients was carried out to help refine the items, define the scoring system and improve inter-rater reliability among the five raters. Then, a validation study on 100 patients with different clinical conditions was carried out. The Italian MT-SAS was used throughout the process, although we also provide an English translation. The final scale consisted of 7 binary items accounting for eye contact, countenance, and nonverbal and sound-music communication. In the pilot study, raters were found to share an acceptable level of agreement in their assessments. Explorative factorial analysis disclosed a single homogeneous factor including 6 items (thus supporting an ordinal total score), with only the item about eye contact being unrelated to the others. Moreover, the existence of 2 different archetypal profiles of attuned and disattuned behaviours was highlighted through multiple correspondence analysis. As suggested by the consistent results of 2 different analyses, MT-SAS is a reliable tool that globally evaluates sonorous-musical and nonverbal behaviours related to emotional attunement and empathetic relationship between patient and therapist during active MT sessions. Copyright © 2017 John Wiley & Sons, Ltd.

  14. Phenethyl isothiocyanate suppresses EGF-stimulated SAS human oral squamous carcinoma cell invasion by targeting EGF receptor signaling.

    Science.gov (United States)

    Chen, Hui-Jye; Lin, Chung-Ming; Lee, Chao-Ying; Shih, Nai-Chen; Amagaya, Sakae; Lin, Yung-Chang; Yang, Jai-Sing

    2013-08-01

    Phenethyl isothiocyanate (PEITC) is a natural compound that is involved in chemoprevention as well as inhibition of cell growth and induction of apoptosis in several types of cancer cells. Previous studies have revealed that PEITC suppresses the invasion of AGS gastric and HT-29 colorectal cancer cells. However, the effects of PEITC on the metastasis of SAS oral cancer cells remain to be determined. Our results showed that PEITC treatment inhibited the invasion of EGF-stimulated SAS cells in a concentration-dependent manner, but appeared not to affect the cell viability. The expression and enzymatic activities of matrix metalloprotease-2 (MMP-2) and matrix metalloprotease-9 (MMP-9) were suppressed by PEITC. Concomitantly, we observed an increase in the protein expression of both tissue inhibitor of metalloproteinase-1 (TIMP-1) and -2 (TIMP-2) in treated cells. Furthermore, PEITC treatments decreased the protein phosphorylation of epidermal growth factor receptor (EGFR) and downstream signaling proteins including PDK1, PI3K (p85), AKT, phosphorylated IKK and IκB to inactivate NF-κB for the suppression of MMP-2 and MMP-9 expression. In addition, PEITC can trigger the MAPK signaling pathway through the increase in phosphorylated p38, JNK and ERK in treated cells. Our data indicate that PEITC is able to inhibit the invasion of EGF-stimulated SAS oral cancer cells by targeting EGFR and its downstream signaling molecules and finally lead to the reduced expression and enzymatic activities of both MMP-2 and MMP-9. These results suggest that PEITC is promising for the therapy of oral cancer metastasis.

  15. Atomistic modelling of scattering data in the Collaborative Computational Project for Small Angle Scattering (CCP-SAS).

    Science.gov (United States)

    Perkins, Stephen J; Wright, David W; Zhang, Hailiang; Brookes, Emre H; Chen, Jianhan; Irving, Thomas C; Krueger, Susan; Barlow, David J; Edler, Karen J; Scott, David J; Terrill, Nicholas J; King, Stephen M; Butler, Paul D; Curtis, Joseph E

    2016-12-01

    The capabilities of current computer simulations provide a unique opportunity to model small-angle scattering (SAS) data at the atomistic level, and to include other structural constraints ranging from molecular and atomistic energetics to crystallography, electron microscopy and NMR. This extends the capabilities of solution scattering and provides deeper insights into the physics and chemistry of the systems studied. Realizing this potential, however, requires integrating the experimental data with a new generation of modelling software. To achieve this, the CCP-SAS collaboration (http://www.ccpsas.org/) is developing open-source, high-throughput and user-friendly software for the atomistic and coarse-grained molecular modelling of scattering data. Robust state-of-the-art molecular simulation engines and molecular dynamics and Monte Carlo force fields provide constraints to the solution structure inferred from the small-angle scattering data, which incorporates the known physical chemistry of the system. The implementation of this software suite involves a tiered approach in which GenApp provides the deployment infrastructure for running applications on both standard and high-performance computing hardware, and SASSIE provides a workflow framework into which modules can be plugged to prepare structures, carry out simulations, calculate theoretical scattering data and compare results with experimental data. GenApp produces the accessible web-based front end termed SASSIE-web, and GenApp and SASSIE also make community SAS codes available. Applications are illustrated by case studies: (i) inter-domain flexibility in two- to six-domain proteins as exemplified by HIV-1 Gag, MASP and ubiquitin; (ii) the hinge conformation in human IgG2 and IgA1 antibodies; (iii) the complex formed between a hexameric protein Hfq and mRNA; and (iv) synthetic 'bottlebrush' polymers.

  16. Analysis of Correlates in SAS.SDS and MMPI of Stutters%口吃患者MMPI与SAS、SDS的相关分析

    Institute of Scientific and Technical Information of China (English)

    刘盈; 丁宝坤; 肖可畏; 石文惠; 李晓东; 王晓武; 孙晓敏

    2001-01-01

    Objective:To investigate the personality feature of stuttering. Methods: SAS, SDS, MMPI were administered to 108 patients with stuttering, 110 normal controls, 103 patients with OCD, 137 patients with depression. Results: The scores of F, K, D, Mf, Pa, Pt, Sc, Si in stuttering group were significantly differen from OCD and depression groups. The scores of SAS were positively correlated with the score of F, D, Ht, Pd, Pt, Sc, Si. Conclusion: The personality feature of stuttering were depressive and compulsive personality.

  17. ¿Cuáles son las consecuencias jurídicas de constituir una Sociedad por Acciones Simplificada (SAS) para hacer fraude a la ley?

    OpenAIRE

    Pinchao, Edith

    2015-01-01

    Abstract: The Sociedades por Acciones Simplificadas, commonly known as SAS, offer to their stockholders a kind of company with multiple economic and juridical benefits. Nevertheless, this has caused that some of these SAS have been created with the aim to do fraud or to harm third parties, i.e. they are constituted with illicit purposes. As a result, the limited responsibility of partners becomes unlimited and shared; removing corporate image from juridical person, a legal phenomenon named di...

  18. Escala de sociotropía-autonomía (SAS: propiedades psicométricas de la adaptación a Colombia

    Directory of Open Access Journals (Sweden)

    Ronald Alberto Toro Tobar

    2014-07-01

    Full Text Available Este artículo presenta los resultados de una investigación cuyo objetivo fue adaptar y validar la Escala de Sociotropía-Autonomía (SAS de Clark & Beck, la cual evalúa dos dimensiones de personalidad cognitiva: la orientación interpersonal y actitudes de logro y metas personales. La muestra consistió en 460 participantes entre 15 y 71 años, escolarizados de distintos estratos socioeconómicos. Los resultados mostraron índices de consistencia interna en la Escala SAS: total (,85, SAS Sociotropía (,82 y menores para SAS autonomía (,61. Estos resultados guardan relación con investigaciones acerca de este instrumento; por lo tanto se considera confiable y válido para el contexto sociocultural; además podría apoyar la investigación en psicoterapia cognitiva y en procesos clínicos basados en el modelo diátesis estrés. Abstract This paper presents the results of a study whose aim was adapt and validate the Sociotropy-Autonomy Scale (SAS Clark & Beck. This scale assesses two dimensions of cognitive personality: interpersonal orientation and attitudes of achievement and personal goals. The sample consisted of 460 participants between 15 and 71 years enrolled from different socioeconomic levels. The results showed internal consistency in SAS Scale: Total (.85, SAS Sociotropy (.82 and lower for SAS Autonomy (.61. These results are relevant to research on this instrument. It is considered a reliable and valid instrument for socio-cultural context; could also support research in cognitive psychotherapy and clinical processes based on the diathesis stress model.

  19. SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test.

    Science.gov (United States)

    O'Connor, B P

    2000-08-01

    Popular statistical software packages do not have the proper procedures for determining the number of components in factor and principal components analyses. Parallel analysis and Velicer's minimum average partial (MAP) test are validated procedures, recommended widely by statisticians. However, many researchers continue to use alternative, simpler, but flawed procedures, such as the eigenvalues-greater-than-one rule. Use of the proper procedures might be increased if these procedures could be conducted within familiar software environments. This paper describes brief and efficient programs for using SPSS and SAS to conduct parallel analyses and the MAP test.

  20. Exploring item and higher order factor structure with the Schmid-Leiman solution: syntax codes for SPSS and SAS.

    Science.gov (United States)

    Wolff, Hans-Georg; Preising, Katja

    2005-02-01

    To ease the interpretation of higher order factor analysis, the direct relationships between variables and higher order factors may be calculated by the Schmid-Leiman solution (SLS; Schmid & Leiman, 1957). This simple transformation of higher order factor analysis orthogonalizes first-order and higher order factors and thereby allows the interpretation of the relative impact of factor levels on variables. The Schmid-Leiman solution may also be used to facilitate theorizing and scale development. The rationale for the procedure is presented, supplemented by syntax codes for SPSS and SAS, since the transformation is not part of most statistical programs. Syntax codes may also be downloaded from www.psychonomic.org/archive/.

  1. SAS Enterprise Data Integration Server - A Complete Solution Designed To Meet the Full Spectrum of Enterprise Data Integration Needs

    Directory of Open Access Journals (Sweden)

    Silvia BOLOHAN

    2012-05-01

    Full Text Available This paper is about why is Data Integration important for organisations around the world. Organizations struggle daily with the challenges of large distributed data volumes, inconsistently defined data across disparate systems and the high expectations of data consumers who depend on information to be correct, complete and available when they need it. SAS Enterprise Data Integration Server provides a comprehensive solution that enables organizations to solve these challenges in a timely, cost-effective manner with the ability to efficiently manage data integration projects on an enterprise scale, increasing overall productivity and reducing the total cost of ownership.

  2. Estructuración de un modelo de gestión eficiente para AJ Colombia SAS

    OpenAIRE

    Vargas Gallego, Daniel Felipe; Morales Chavez, Daniela; Ortega Diaz, Melissa

    2016-01-01

    En la mayoría de los países, los negocios familiares representan un alto porcentaje de todas las empresas constituidas. Colombia no es la excepción a este comportamiento, donde las empresas familiares representan el 70% de todas las compañías, según la Superintendencia de Sociedades, en las que se incluyen PYMES y grandes grupos económicos. Este trabajo de grado tiene como objetivo estructurar un modelo de gestión eficiente para la empresa AJ Colombia S.A.S. una empresa mediana que se ha v...

  3. 基于 SAS 机床行业发展的数量化研究%Quantification Study of the Development of the Machine Tool Industry Based on SAS

    Institute of Scientific and Technical Information of China (English)

    翟芳婷

    2014-01-01

    Obtained large historical data of 11 typical industry and six machine tool companies from the stock market by using SAS software ,we get a mathematical formula about the development of machine tool industry by SAS programming , principal component analysis method and multivariate linear regression analysis method .This formula reflects the relationship between the development of machine tool industry and the national economy ,infrastructure ,the real estate .The study pro-vide a reference for the future development and investment of machine tool industry .%利用SAS软件从证券市场上获取11个典型行业和6家机床公司2008~2013年的庞大经济数据,通过SAS编程借助主成份分析法和多元线性回归分析法建立了影响机床行业发展的模型方程,数量化阐述了机床行业发展指数与国民经济、基础设施和房地产三者发展的关系,为机床行业的未来发展及投资提供借鉴。

  4. Développement d'outils de mesure pour l'amélioration du procédé d'impression offset

    Science.gov (United States)

    Boumaïza, K.; Baudin, G.; Catusse, R.; Viallet, A.

    1999-03-01

    The offset printing process rests primarily on the balance between ink and damping solution. However, this balance remains difficult to realize. The corresponding wastes of time and into consumable (ink, paper and damping solution) are harmful for the industrialist, the consumer and the environment. The main feature of this work is to control and thus to optimize these flux. With this intention, two optical sensors functioning in reflection were developed. A laser with receiving photodiode for the control of damping solution film thickness, and an optical fiber related to a photoelectric sensor for control of ink film thickness. The current study aims at the calibration of these two sensors for respectively the control of water and ink flux in the offset press. Le procédé d'impression offset repose essentiellement sur l'équilibre entre la solution de mouillage et l'encre. Toutefois, cet équilibre reste une tâche difficile à réaliser. Les pertes en temps et en consommables (encre, papier, solution de mouillage) correspondantes sont nuisibles à la fois pour l'industriel, le consommateur et l'environnement. L'objectif de ce travail est de contrôler et donc d'optimiser ces flux pour un tirage donné. Pour ce faire, deux capteurs de type optique fonctionnant en réflexion ont été développés. Un laser avec photodiode réceptrice pour le contrôle du film de solution de mouillage, et une fibre optique liée à un capteur photoélectrique pour le contrôle du film d'encre. L'étude actuelle vise la mise en ouvre et l'étalonnage de ces deux capteurs pour la mesure et le contrôle des films respectifs d'eau et d'encre dans la presse offset.

  5. The High Throughput Sequence Annotation Service (HT-SAS – the shortcut from sequence to true Medline words

    Directory of Open Access Journals (Sweden)

    Siedlecki Pawel

    2009-05-01

    Full Text Available Abstract Background Advances in high-throughput technologies available to modern biology have created an increasing flood of experimentally determined facts. Ordering, managing and describing these raw results is the first step which allows facts to become knowledge. Currently there are limited ways to automatically annotate such data, especially utilizing information deposited in published literature. Results To aid researchers in describing results from high-throughput experiments we developed HT-SAS, a web service for automatic annotation of proteins using general English words. For each protein a poll of Medline abstracts connected to homologous proteins is gathered using the UniProt-Medline link. Overrepresented words are detected using binomial statistics approximation. We tested our automatic approach with a protein test set from SGD to determine the accuracy and usefulness of our approach. We also applied the automatic annotation service to improve annotations of proteins from Plasmodium bergei expressed exclusively during the blood stage. Conclusion Using HT-SAS we created new, or enriched already established annotations for over 20% of proteins from Plasmodium bergei expressed in the blood stage, deposited in PlasmoDB. Our tests show this approach to information extraction provides highly specific keywords, often also when the number of abstracts is limited. Our service should be useful for manual curators, as a complement to manually curated information sources and for researchers working with protein datasets, especially from poorly characterized organisms.

  6. Benchmark of SCALE (SAS2H) isotopic predictions of depletion analyses for San Onofre PWR MOX fuel

    Energy Technology Data Exchange (ETDEWEB)

    Hermann, O.W.

    2000-02-01

    The isotopic composition of mixed-oxide (MOX) fuel, fabricated with both uranium and plutonium, after discharge from reactors is of significant interest to the Fissile Materials Disposition Program. The validation of the SCALE (SAS2H) depletion code for use in the prediction of isotopic compositions of MOX fuel, similar to previous validation studies on uranium-only fueled reactors, has corresponding significance. The EEI-Westinghouse Plutonium Recycle Demonstration Program examined the use of MOX fuel in the San Onofre PWR, Unit 1, during cycles 2 and 3. Isotopic analyses of the MOX spent fuel were conducted on 13 actinides and {sup 148}Nd by either mass or alpha spectrometry. Six fuel pellet samples were taken from four different fuel pins of an irradiated MOX assembly. The measured actinide inventories from those samples has been used to benchmark SAS2H for MOX fuel applications. The average percentage differences in the code results compared with the measurement were {minus}0.9% for {sup 235}U and 5.2% for {sup 239}Pu. The differences for most of the isotopes were significantly larger than in the cases for uranium-only fueled reactors. In general, comparisons of code results with alpha spectrometer data had extreme differences, although the differences in the calculations compared with mass spectrometer analyses were not extremely larger than that of uranium-only fueled reactors. This benchmark study should be useful in estimating uncertainties of inventory, criticality and dose calculations of MOX spent fuel.

  7. Moving-Bed Process for Residue Hydrotreating Procédé à lit mobile pour l'hydrotraitement des résidus

    Directory of Open Access Journals (Sweden)

    Euzen J. P.

    2006-11-01

    the solid particles during the sequential withdrawal. It is the reason why the movement of the solid and, moreover, the residence time distribution of the catalyst particles have been especially followed. To this end, a new technique has been developed to measure the concentration of magnetically marked particles. Furthermore, a specific effort has been devoted to technological problems such as selection and developement of special valves able to insure efficient tightness between the various sections at elevated temperatures and pressures in the presence of solid particles. Another study has been devoted to the operation of addition and withdrawal of the catalyst to and from the reactor running at high pressure and temperature. The solid flows and the catalyst transfer conditions have been carefully studied and tested. Finally a demonstration unit has been built at a semi-industrial scale in a mini-refinery. It was a convincing way to check all the conclusions drawed from the developement step with models, smaller scale pilots and mock-ups. As the fluids and the catalyst were real industrial products, the feasibility of the whole process has been demonstrated. Therefore, a new industrial process using the countercurrent moving bed is now available and permits a very efficient use of the catalyst particles. Un grand nombre de procédés chimiques, pétrochimiques ou de raffinage nécessitent un contact entre 3 phases : un produit de base liquide, un réactif gazeux et un catalyseur solide. Il arrive souvent que l'activité du catalyseur soit réduite par un empoisonnement des sites actifs ou par des dépôts de coke. C'est particulièrement le cas des procédés utilisés dans l'hydrotraitement des résidus lourds. La durée de vie du catalyseur étant réduite, il est nécessaire de remplacer ou de régénérer fréquemment le catalyseur devenu inactif. Différentes solutions permettent d'effectuer ce travail tout en limitant les pertes de temps et de production

  8. EDITORIAL Proceedings of the XIV International Conference on Small-Angle Scattering, SAS-2009

    Science.gov (United States)

    Ungar, Goran; Heenan, Richard

    2010-10-01

    particles based on the radial pair distance distribution function. The model takes account of different types of disorder, i.e. of both 1st ('thermal') and 2nd ('paracrystalline') kind, as well as finite size, stacking and orientational disorder. In paper 012014 Salvino Ciccariello works out the 3D correlation function of plane objects, specifically a triangle of a general shape. This paves the way to analysing morphologies that can be approximated by cylinders of different cross-sections. Papers 012051 (Polte et al.) and 012047 (Bras et al.) report the use of SAS in combination with X-ray spectroscopy. Ristic et al. describe a real-time study of crystal nucleation induced by ultrasound (012049), while Marianne Imperor-Clerc et al. present an investigation of lyotropic liquid crystals under shear (012052). In the Polymers section Geoff Mitchell describes modelling of SANS data on electrospun fibres (012042), while Cabral et al. describes a study of nanoparticle aggregation in bulk and thin polymer films (012046). Work on phospholipid membranes was reported by Spinozzi et al. and by Onai et al. in papers 012019 and 012018, respectively. The latter deals with the effect of osmotic pressure on model 'lipid rafts', these being considered as having an important role in the function of the mammalian cell membrane. Readers interested in biological systems will find a number of other interesting papers describing the use of either SAXS or SANS in the Biological Systems and Membranes section. A number of descriptions of recent designs of SAXS (synchrotron) and SANS beamlines, as well as detector developments can be found in the section on Beamlines and Instrumentation. Goran Ungar, Editor-in-Chief Richard Heenan, Deputy Editor-in-Chief

  9. POSO-MA-SAS 三元共聚物的制备及脱墨应用%Synthesis of terpolymer surfactant POSO-MA-SAS and its deinking performance

    Institute of Scientific and Technical Information of China (English)

    张昌辉; 李强; 李丹; 崔丽萍

    2014-01-01

    The terpolymer anionic surfactant POSO-MA-SAS was synthesized by copolymeri-zation reaction of potassium sorbate (POSO) ,methyl acrylate (MA) and sodium allyl sulfon-ate (SAS) .The better synthesis process and the application to waste paper deinking used washing method was studied ,and terpolymer compounded performance was compared with commercial deinking agent .It was found that the better synthesis condition was determined as follow s :the molar ratio of potassium sorbate (POSO ) to methyl acrylate (M A ) to sodi-um allyl sulfonate (SAS) was 1∶3∶1 at 90 ℃ for 5 h ,dosage of initiator is 6% of monomer mass fraction .The terpolymer has good deinking effect ;the deinking effect was further im-prove when terpolymer compound with AES as the ratio 1∶1 .Compound dosage was 0 .2% , the whiteness of the paper deinked can be increased by 3 .8% ISO compared with commercial-ly available deinking agent and the residual ink concentration was 49 .53 mm2 · m -2 .%以山梨酸钾(POSO)、丙烯酸甲酯(MA)和烯丙基磺酸钠(SAS)为单体通过共聚反应制得POSO-M A-SAS三元共聚物阴离子表面活性剂.研究了最佳合成工艺,考察了共聚物在洗涤法废纸脱墨中的应用,复配后与市售脱墨剂进行了对比.结果表明,当 n(POSO )∶ n (MA)∶ n(SAS)=1∶3∶1,聚合反应温度为90℃,聚合反应时间5 h ,引发剂用量为单体总质量6%时,共聚物具有较好洗涤脱墨效果;共聚物与A ES复配使用时洗涤脱墨效果进一步提高,当m(POSO-MA-SAS)∶ m(AES)=1∶1,用量为0.2%时,脱墨后成纸白度相比市售脱墨剂提高3.8% ISO ,残余油墨量仅为49.53 mm2· m -2.

  10. Comprehensive analysis of interacting proteins and genome-wide location studies of the Sas3-dependent NuA3 histone acetyltransferase complex.

    Science.gov (United States)

    Vicente-Muñoz, Sara; Romero, Paco; Magraner-Pardo, Lorena; Martinez-Jimenez, Celia P; Tordera, Vicente; Pamblanco, Mercè

    2014-01-01

    Histone acetylation affects several aspects of gene regulation, from chromatin remodelling to gene expression, by modulating the interplay between chromatin and key transcriptional regulators. The exact molecular mechanism underlying acetylation patterns and crosstalk with other epigenetic modifications requires further investigation. In budding yeast, these epigenetic markers are produced partly by histone acetyltransferase enzymes, which act as multi-protein complexes. The Sas3-dependent NuA3 complex has received less attention than other histone acetyltransferases (HAT), such as Gcn5-dependent complexes. Here, we report our analysis of Sas3p-interacting proteins using tandem affinity purification (TAP), coupled with mass spectrometry. This analysis revealed Pdp3p, a recently described component of NuA3, to be one of the most abundant Sas3p-interacting proteins. The PDP3 gene, was TAP-tagged and protein complex purification confirmed that Pdp3p co-purified with the NuA3 protein complex, histones, and several transcription-related and chromatin remodelling proteins. Our results also revealed that the protein complexes associated with Sas3p presented HAT activity even in the absence of Gcn5p and vice versa. We also provide evidence that Sas3p cannot substitute Gcn5p in acetylation of lysine 9 in histone H3 in vivo. Genome-wide occupancy of Sas3p using ChIP-on-chip tiled microarrays showed that Sas3p was located preferentially within the 5'-half of the coding regions of target genes, indicating its probable involvement in the transcriptional elongation process. Hence, this work further characterises the function and regulation of the NuA3 complex by identifying novel post-translational modifications in Pdp3p, additional Pdp3p-co-purifying chromatin regulatory proteins involved in chromatin-modifying complex dynamics and gene regulation, and a subset of genes whose transcriptional elongation is controlled by this complex.

  11. Immunomagnetic separation and visual fluorescence detection of E. coli O157 using AOAC approved SAS Molecular Tests.

    Science.gov (United States)

    Bapanpally, Chandra; Maganty, Gayatri; Khan, Shah; Kasra, Akif; Morey, Amit

    2014-01-01

    The SAS Molecular Tests method for the detection of E. coli O157 in various food matrixes has been certified by the AOAC Research Institute and designated Performance Tested Method No. 031203. The current method modification includes the optional immunomagnetic separation (IMS) to enrich the bacteria as well as optional visual fluorescence readout without the use of a turbidimeter. The following study was conducted to validate the proposed modifications against the U.S. Department of Agriculture/Food Safety and Inspection Service Microbiology Laboratory Guidebook (MLG) and the U.S. Food and Drug Administration Bacteriological Analytical Manual (BAM) reference methods. E. coli O157:H7 ATCC 35150 and NM (non-motile) 700377 strains were used to inoculate the ground beef, beef trim, and spinach to obtain 20 low (0.23-2 CFU/test portion) and five high levels (3-5 CFU/test portion) of inoculations. Enriched samples were tested directly and subjected to anti-E. coli IMS prior to the SAS Molecular Tests. Results were determined via visual fluorescence and via turbidity using a turbidimeter. All the replicates, irrespective of the results, were confirmed using MLG 5.05 or BAM Chapter 4A methods. Results indicated that there were no significant differences in the detection of fractional positives (5-15 positives out of 20 replicates) with any of the methods tested above as compared to the reference methods. No false positives or negatives were detected except for two in the ground beef with IMS+Turbidity method. No false-negative samples were detected. Statistical analysis indicated that the modified methods were equivalent to the reference methods in detecting E. coli O157:H7 in the food matrixes tested. SAS Molecular Tests E. coli O157 Detection Kit can be used to detect E. coli O157:H7 in ground beef, beef trim, and spinach. The inclusion of IMS in the modified method improved the detection rate of E. coli O157:H7 in spinach and showed comparable detection rate in ground

  12. Design of a Road Friendly SAS System for Heavy-Duty Vehicles Based on a Fuzzy-Hybrid-ADD and GH-Control Strategy

    Directory of Open Access Journals (Sweden)

    Jing Zhao

    2016-01-01

    Full Text Available Semiactive suspension (SAS system has been widely used for its outstanding performance in offering competent ride quality, road holding, and handling capacity. However, the road friendliness is also one of the crucial factors that should be attached in the design of the SAS system for heavy-duty vehicles. In this study, a fuzzy controlled hybrid-acceleration driven damper (ADD and ground hook- (GH- control strategy is proposed for SAS system of heavy-duty vehicles. Firstly, a quarter-vehicle model with SAS system is constructed. Then, aiming to improve the ride quality and road friendliness, a hybrid-ADD and GH-control strategy is proposed under the coordination of the fuzzy controller. Numerical results show that the ride quality and road friendliness of the SAS system with the proposed control strategy outperform those with traditional hybrid-sky hook and ground hook-control strategy. It is also verified that the proposed strategy is superior to the sole ADD approach and sole ground hook approach in improving the vehicle overall performance.

  13. El procés d'integració de la primera biblioteca interuniversitària d'Espanya : la Biblioteca del campus universitari de Manresa

    Directory of Open Access Journals (Sweden)

    Riu Amblàs, Trini

    2015-12-01

    Full Text Available Fa deu anys, la biblioteca de l'Escola Politècnica Superior d'Enginyeria de Manresa de la Universitat Politècnica de Catalunya, la de la Fundació Universitària del Bages i la del Centre de Suport del Bages de la Universitat Oberta de Catalunya, s'integraven per formar una única biblioteca universitària: la Biblioteca del campus universitari de Manresa. Amb l'objectiu de descriure aquest procés d'integració, s'introdueix què són les biblioteques integrades, se n'enumeren els beneficis i se'n presenten els diferents models. A continuació, partint de l'experiència, es defineixen les actuacions dutes a terme per aconseguir la integració total d'usuaris, recursos i serveis, i es descriu l'estructura i organització creades per integrar de manera eficient les biblioteques existents en una de nova. Així, s'analitza el context i es descriu la gestió duta a terme en cada una de les fases del procés, des de la planificació i definició del projecte fins a la integració total del personal, els serveis, el fons i el catàleg. Finalment, es posen de manifest les aportacions de l'experiència d'integrar-se i treballar conjuntament durant deu anys.Hace diez años, la biblioteca de la Escola Politècnica Superior d'Enginyeria de Manresa de la Universitat Politècnica de Catalunya, la de la Fundació Universitària del Bages y la del Centre de Suport del Bages de la Universitat Oberta de Catalunya se integraban para formar una única biblioteca universitaria: la Biblioteca del campus universitario de Manresa. Con el objetivo de describir este proceso de integración, se introduce qué son las bibliotecas integradas, se enumeran sus beneficios y se presentan sus diferentes modelos. A continuación, partiendo de la experiencia, se definen las actuaciones llevadas a cabo para conseguir la integración total de usuarios, recursos y servicios, y se describe la estructura y organización creadas para integrar de manera eficiente las bibliotecas

  14. SPSS and SAS programs for addressing interdependence and basic levels-of-analysis issues in psychological data.

    Science.gov (United States)

    O'Connor, Brian P

    2004-02-01

    Levels-of-analysis issues arise whenever individual-level data are collected from more than one person from the same dyad, family, classroom, work group, or other interaction unit. Interdependence in data from individuals in the same interaction units also violates the independence-of-observations assumption that underlies commonly used statistical tests. This article describes the data analysis challenges that are presented by these issues and presents SPSS and SAS programs for conducting appropriate analyses. The programs conduct the within-and-between-analyses described by Dansereau, Alutto, and Yammarino (1984) and the dyad-level analyses described by Gonzalez and Griffin (1999) and Griffin and Gonzalez (1995). Contrasts with general multilevel modeling procedures are then discussed.

  15. SAS and SPSS macros to calculate standardized Cronbach's alpha using the upper bound of the phi coefficient for dichotomous items.

    Science.gov (United States)

    Sun, Wei; Chou, Chih-Ping; Stacy, Alan W; Ma, Huiyan; Unger, Jennifer; Gallaher, Peggy

    2007-02-01

    Cronbach's a is widely used in social science research to estimate the internal consistency of reliability of a measurement scale. However, when items are not strictly parallel, the Cronbach's a coefficient provides a lower-bound estimate of true reliability, and this estimate may be further biased downward when items are dichotomous. The estimation of standardized Cronbach's a for a scale with dichotomous items can be improved by using the upper bound of coefficient phi. SAS and SPSS macros have been developed in this article to obtain standardized Cronbach's a via this method. The simulation analysis showed that Cronbach's a from upper-bound phi might be appropriate for estimating the real reliability when standardized Cronbach's a is problematic.

  16. Mediation analysis allowing for exposure-mediator interactions and causal interpretation: theoretical assumptions and implementation with SAS and SPSS macros.

    Science.gov (United States)

    Valeri, Linda; Vanderweele, Tyler J

    2013-06-01

    Mediation analysis is a useful and widely employed approach to studies in the field of psychology and in the social and biomedical sciences. The contributions of this article are several-fold. First we seek to bring the developments in mediation analysis for nonlinear models within the counterfactual framework to the psychology audience in an accessible format and compare the sorts of inferences about mediation that are possible in the presence of exposure-mediator interaction when using a counterfactual versus the standard statistical approach. Second, the work by VanderWeele and Vansteelandt (2009, 2010) is extended here to allow for dichotomous mediators and count outcomes. Third, we provide SAS and SPSS macros to implement all of these mediation analysis techniques automatically, and we compare the types of inferences about mediation that are allowed by a variety of software macros.

  17. VecDec4SAS program for analyzing the dynamic processes observed by the small-angle scattering technique

    Science.gov (United States)

    Molodenskii, D. S.

    2017-01-01

    A VecDec4SAS program has been developed to provide a fast and easy description of the dynamics of any process occurring in a nanoparticle solution observed by the small-angle scattering technique. The process should be characterized by the some conditional initial and final stages, in fractions of which all intermediate data are expanded. The program makes it possible to estimate the adequacy of two-basis approximation and indicate the presence of an additional process introducing a systematic error into the initial data. Scattering curves for human serum albumin protein in solutions with pH 7.4 and 3.0 and a concentration of 20 mg/mL, obtained on the DICSY station at the National Research Centre "Kurchatov Institute" in the solution temperature range from 25 to 70°C, were taken to be initial data to illustrate the potential of the program.

  18. Modification of the SAS4A Safety Analysis Code for Integration with the ADAPT Discrete Dynamic Event Tree Framework.

    Energy Technology Data Exchange (ETDEWEB)

    Jankovsky, Zachary Kyle [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Denman, Matthew R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-05-01

    It is difficult to assess the consequences of a transient in a sodium-cooled fast reactor (SFR) using traditional probabilistic risk assessment (PRA) methods, as numerous safety-related sys- tems have passive characteristics. Often there is significant dependence on the value of con- tinuous stochastic parameters rather than binary success/failure determinations. One form of dynamic PRA uses a system simulator to represent the progression of a transient, tracking events through time in a discrete dynamic event tree (DDET). In order to function in a DDET environment, a simulator must have characteristics that make it amenable to changing physical parameters midway through the analysis. The SAS4A SFR system analysis code did not have these characteristics as received. This report describes the code modifications made to allow dynamic operation as well as the linking to a Sandia DDET driver code. A test case is briefly described to demonstrate the utility of the changes.

  19. Homology modeling and validation of SAS2271 transcriptional regulator of AraC family in Staphylococcus aureus

    Directory of Open Access Journals (Sweden)

    Money Gupta

    2013-02-01

    Full Text Available Objective: To predict three dimensional structure of AraC Family transcription regulator protein in staphylococcus aureus involved in causing virulence. Methods: Evolutionary dynamics of S. aureus reveled that several mutations preceding virulence lead to truncated proteins that plays an important role in virulence. The Structural templates are identified using homology search and then homology modelling is used to get the 3-D structure of the protein. Results: The 3-D structure of SAS2271 transcriptional factor of AraC family in MSSA476 strain of S. aureus was modelled and validated using the Ramachandran plot. Conclusions: The knowledge of 3-D structure of the protein will be helpful in identifying its biochemical function along with its regulatory mechanism in causing virulence.

  20. Data Ellipses, HE Plots and Reduced-Rank Displays for Multivariate Linear Models: SAS Software and Examples

    Directory of Open Access Journals (Sweden)

    Michael Friendly

    2006-11-01

    Full Text Available This paper describes graphical methods for multiple-response data within the framework of the multivariate linear model (MLM, aimed at understanding what is being tested in a multivariate test, and how factor/predictor effects are expressed across multiple response measures. In particular, we describe and illustrate a collection of SAS macro programs for: (a Data ellipses and low-rank biplots for multivariate data, (b HE plots, showing the hypothesis and error covariance matrices for a given pair of responses, and a given effect, (c HE plot matrices, showing all pairwise HE plots, and (d low-rank analogs of HE plots, showing all observations, group means, and their relations to the response variables.

  1. Battlefield Utility of Antipersonnel Landmines and Proposed Alternatives (Analysis in Support of the NATO SAS-023 APM Study)

    Energy Technology Data Exchange (ETDEWEB)

    Crandley, J F; Greenwalt, R J; Magnoli, D E; Randazzo, A S

    2002-02-05

    This study consists of work done in support of the U.S. delegation to the NATO SAS-023 Antipersonnel Landmine Study Group, supplemented by additional work done for the U.S. Office of the Secretary of Defense Antipersonnel Landmine Alternative Concept Exploration Program (Track III). It explores the battlefield utility of current antipersonnel landmines (APL) in both pure and mixed APL/antitank minefields and evaluates the value of military suggested non-materiel alternatives. The historical record is full of examples where the presence (or absence) of antipersonnel landmines made a critical difference in battle. The current generation of military thinkers and writers lack any significant combat experience employing either mixed or antipersonnel minefields, which leaves a critical gap in available expert advice for policy and decision-makers. Because of this lack of experienced-based professional military knowledge, Lawrence Livermore National Laboratory analyzed the employment of antipersonnel landmines in tactical mixed minefields and in protective antipersonnel minefields. The scientific method was employed where hypotheses were generated from the tactics and doctrine of the antipersonnel landmine era and tested in a simulation laboratory. A high-resolution, U.S. Joint Forces Command combat simulation model (the Joint Conflict and Tactical Simulation--JCATS) was used as the laboratory instrument. A realistic European scenario was obtained from a multi-national USAREUR exercise and was approved by the SAS-023 panel members. Additional scenarios were provided by U.S. CINC conferences and were based on Southwest Asia and Northeast Asia. Weapons data was obtained from the U.S. family of Joint Munitions Effectiveness Manuals. The U.S. Army Materiel Systems Analysis Agency conducted a limited verification and validation assessment of JCATS for purposes of this study.

  2. The Spectral Analysis of X-Ray Binaries from the XMM-Newton Space Craft Data using SAS Software

    Science.gov (United States)

    Baki, P.; Mito, C. O.

    2009-10-01

    A spectral data analysis on a luminous object of sky-coordinates 12h52m24.28s-29d115'02.3'12.6arcsec using Science Analysis Software (SAS) is presented. The analysis, based on data acquired by the Reflection Grating Spectrometer (RGS) camera aboard the XMM-Newton Space satellite, shows that the primary constituents of the X-ray source are Fe (Iron) and O (oxygen). This suggests that the source may be a magnetized plasma in a binary system and as this magnetic field accelerates the cooling of a star, one may speculate that this may be a compact star in its last stages of a thermonuclear fusion process. Nous présentons une analyse du spectre d'une source a rayons X située -- en coordonnées sidérales - à 12h52m24.28s - 29d115'02.312.6 arcsec. Science Analysis Software (SAS) est le programme informatique utilisé pour l'analyse des données. Cette analyse est basée sur les données provenant du spectromètre à haute résolution (RGS) à bord du satellite spatiale XMM-Newton. Nous montrons que ladite source est principalement constituée de Fer (Fe) et d'oxygene (O). Ce résultat suggère que la source pourrait être un plasma magnétisé au sein d'un système binaire. Et du fait que ce champ magnétique accélère le refroidissement de l'étoile, nous supposons que cette étoile pourrait ètre un objet compact en phase terminale d'un processus de fusion thermonucléaire.

  3. 新的细胞壁锚定蛋白SasX对金黄葡萄球菌生物膜形成和毒力的影响%The novel surface-anchored protein SasX promotes biofilm formation and is a virulence factor of Staphylococcus aureus

    Institute of Scientific and Technical Information of China (English)

    杜昕; 宋燕; 胡锦辉; 阮斐怡; 吕元; 李敏

    2011-01-01

    Objective To determine whether the novel surface-anchored protein SasX mediates biofilm formation of Staphylococcus aureus and to investigate the function of SasX in the virulence of S.aureus.Methods Methicillin-resistant Staphylococcus aureus(MRSA) ST-239 HS sasX gene mutant (HS770 △ sasX) and complement [ HS770 △sasX(pRBsasX) ] were gotten by gene knock out and complement methods.Semiquantitative biofilm assay was used for detection of the biofilm formation of wild type and mutant.By using abscess model in mice,we investigate the function of SasX in the virulence of S.aureus.Results The sasX gene mutant strain was gotten successfully by using pKOR1 plasmid.HS770 △sasX with a very clear reduction of biofilm formation compared to wild type and complement(P<0.05),there was no significant difference of biofilm formation between wild type and complement(P>0.05).Primary attachment assays demonstrated that comparing to wild type,there was significant reduction of initial accumulative phases of biofilm development in HS770△sasX(P<0.05),but there was no difference between wild type and complement(P>0.05).Both sasX wild type and mutant could cause abscess in the skin of mice,no abscess were forming in the PBS control group.The biggest abscess size was found on the second day after injection.The size of abscess was smaller with extension of the time.But on the same time,the wild type group produced significantly larger abscesses compared to mutant group( P<0.05 ).Conclusion It could improve the effect of gene knocking out by using pKOR1 plasmid.SasX promotes biofilm formation by influencing on the initial accumulative phases of biofilm development,SasX is a marker of invasive infection of S.aureus,it is very important for S.aureus persistence in the hospital setting.%目的 研究新的细胞壁锚定蛋白SasX对金黄葡萄球菌生物膜形成及毒力的影响.方法 采用基因敲除及基因互补技术获得耐甲

  4. Distribution of the novel cell wall anchored protein-encoding gene sasX in Staphylococcus aureus strains%新的细胞壁锚定蛋白编码基因sasX在金黄色葡萄球菌中的分布

    Institute of Scientific and Technical Information of China (English)

    杜昕; 宋燕; 田月如; 阮斐怡; 吕元; 李敏

    2011-01-01

    Objective To investigate the distribution and effect on antibiotic resistance of the novel cell wall anchored protein-encoding gene sasX.Methods A total of 300 S.aureus isolates were randomly collected from inpatients with S.aureus infection in Shanghai Huashan hospital in 2004, 2007 and 2010.Meanwhile,170 S.aureus isolates from the nasal swabs of healthy people were collected as part of a population-based community prevalence study.Typing of S.aureus isolates were identified by using multilocus sequence typing (MLST) and S.aureus-specific staphylococcal protein A typing (spa typing).Determination of oxacillin MICs was used to screen MRSA.PCR and sequencing were used to analyze sasX gene.The effect on antibiotic resistance of sasX gene was detect by disc agar diffusion drug sensitive test.Results The major clonal types of the 300 S.aureus isolates collected from inpatients with S.aureus infection were ST239 ( 110,36.7%) and ST5 (122,40.7%).From 2004 to 2010,the percentage of isolates from inpatients with S.aureus infection was increased from 17% to 39%,but sasX was only found in 0.59% of the S.aureus isolates from the nasal swabs of healthy people.The percentage of sasX positive was increased from 47.2% to 83.8% in ST239.The percentage of sasX positive MRSA was increased from 26.4% to 50.8%,but the percentage of sasX positive MSSA was about 10%.Antibiotic resistance of sasX positive strains were higher than that of sasX negative strains.Conclusions SasX gene is mainly detected in nosocomial pathogenic S.aureus and it is a possible virulence factor of S.aureus in hosptal setting.The presence of sasX gene is related to antibiotic resistance.For better understanding the real function of this novel gene,further studies such as expression of the encoded protein should be carried out.%目的 研究细胞壁锚定蛋白编码基因sasX在金黄色葡萄球菌中的分布及对细菌耐药性的影响.方法 随机收集上海华山医院2004、2007

  5. Combined SAXS/EM Based Models of the S. elongatus Post-Translational Circadian Oscillator and its Interactions with the Output His-Kinase SasA

    Energy Technology Data Exchange (ETDEWEB)

    Pattanayek, Rekha; Williams, Dewight R.; Rossi, Gian; Weigand, Steven; Mori, Tetsuya; Johnson, Carl H.; Stewart, Phoebe L.; Egli, Martin (Vanderbilt); (NWU)

    2012-03-15

    The circadian clock in the cyanobacterium Synechococcus elongatus is composed of a post-translational oscillator (PTO) that can be reconstituted in vitro from three different proteins in the presence of ATP and a transcription-translation feedback loop (TTFL). The homo-hexameric KaiC kinase, phosphatase and ATPase alternates between hypo- and hyper-phosphorylated states over the 24-h cycle, with KaiA enhancing phosphorylation, and KaiB antagonizing KaiA and promoting KaiC subunit exchange. SasA is a His kinase that relays output signals from the PTO formed by the three Kai proteins to the TTFL. Although the crystal structures for all three Kai proteins are known, atomic resolution structures of Kai and Kai/SasA protein complexes have remained elusive. Here, we present models of the KaiAC and KaiBC complexes derived from solution small angle X-ray scattering (SAXS), which are consistent with previous EM based models. We also present a combined SAXS/EM model of the KaiC/SasA complex, which has two N-terminal SasA sensory domains occupying positions on the C-terminal KaiC ring reminiscent of the orientations adopted by KaiB dimers. Using EM we demonstrate that KaiB and SasA compete for similar binding sites on KaiC. We also propose an EM based model of the ternary KaiABC complex that is consistent with the sequestering of KaiA by KaiB on KaiC during the PTO dephosphorylation phase. This work provides the first 3D-catalogue of protein-protein interactions in the KaiABC PTO and the output pathway mediated by SasA.

  6. Diseño de una Oficina de Gestión de Proyectos (PMO) para la empresa RINCCO S.A.S.

    OpenAIRE

    Arias Sánchez, Néstor Jaime

    2015-01-01

    La Reforestadora industrial y comercial de Colombia S.A.S. (RINCCO S.A.S.) empresa del sector forestal, mueble y madera ha definido como visión organizacional ser una empresa líder en producción, transformación y comercialización de productos maderables -- Es un momento clave para empresa, ya que de las decisiones que se tomen hoy, dependerá si esta visión se vuelve una realidad -- Como base para poder emprender este camino deberá establecer en su estructura organizacional procesos que le per...

  7. PERBANDINGAN PEMBELAJARANMEMBACA PERMULAAN DENGAN MENGGUNAKAN METODE SAS DANMETODE KATA LEMBAGA BERDASARKAN PERBEDAAN GAYA BELAJAR PADA PESERTA DIDIK TAMAN KANAK-KANAK

    Directory of Open Access Journals (Sweden)

    Wiwik Kus Endah

    2014-08-01

    Full Text Available Penelitian ini bertujuan untuk membuktikan (1 perbedaan kemampuan membaca permulaan antara peserta didik taman kanak-kanak bergaya belajar auditori dan visual yang dibimbing dengan metode SAS, (2 perbedaan kemampuan membaca permulaan antara peserta didik taman kanak-kanak bergaya belajar auditori dan visual yang dibimbing dengan metode  kata lembaga, (3 interaksi antara penggunaan metode SAS dan metode kata lembaga untuk meningkatkan kemampuan membaca permulaan peserta didik taman kanak-kanak bergaya belajar auditori dan visual. Metode penelitian ini exsperimental design. Teknik pengumpulan data penelitian menggunakan instrumen tes kemampuan membaca permulaan, modality assessment test, wawancara, lembar observasi, dan dokumentasi. Untuk menganalisis data penelitian digunakan one sample kolmogorov-smirnov test pada program SPSS 16, uji homogenitas levene test, dan uji hipotesis dengan analisis varian 2x2. Simpulan hasil penelitian ini yaitu (1 terdapat perbedaan kemampuan membaca permulaan antara peserta didik TK Islam Pangeran Diponegoro yang memiliki gaya belajar auditori dan visual yang dibimbing dengan metode SAS, (2 terdapat perbedaan kemampuan membaca permulaan antara peserta didik TK Islam Pangeran Diponegoro yang memiliki gaya belajar auditori dan visual yang dibimbing dengan metode kata lembaga dan (3 terdapat interaksi antara penggunaan metode pembelajaran (SAS dan kata lembaga dengan gaya belajar (auditori dan visual  pada kemampuan membaca permulaan peserta didik taman kanak-kanak.This study aimed to describe (1 the difference between the beginning reading skills of students kindergarten auditory and visual learning style that is guided by the SAS method; (2 the difference between the beginning reading skills of students kindergarten style learning auditory and visual guided the “kata lembaga”method;and (3 the interaction between the use of SAS methods and methods of ‘kata lembaga”to improve literacy learners beginning

  8. CVD silicon carbide monofilament reinforced SrO-Al2O3-2SiO2 (SAS) glass-ceramic composites

    Science.gov (United States)

    Bansal, Narottam P.

    1995-01-01

    Unidirectional CVD SiC fiber-reinforced SrO.Al2O3.2SiO2 (SAS) glass-ceramic matrix composites have been fabricated by hot pressing at various combinations of temperature, pressure and time. Both carbon-rich surface coated SCS-6 and uncoated SCS-0 fibers were used as reinforcements. Almost fully dense composites have been obtained. Monoclinic celsian, SrAl2Si2O8, was the only crystalline phase observed in the matrix from x-ray diffraction. During three point flexure testing of composites, a test span to thickness ratio of approximately 25 or greater was necessary to avoid sample delamination. Strong and tough SCS-6/SAS composites having a first matrix crack stress of approximately 300 MPa and an ultimate bend strength of approximately 825 MPa were fabricated. No chemical reaction between the SCS-6 fibers and the SAS matrix was observed after high temperature processing. The uncoated SCS-0 fiber-reinforced SAS composites showed only limited improvement in strength over SAS monolithic. The SCS-0/SAS composite having a fiber volume fraction of 0.24 and hot pressed at 1400 deg C exhibited a first matrix cracking stress of approximately 231 +/- 20 MPa and ultimate strength of 265 +/- 17 MPa. From fiber push-out tests, the fiber/matrix interfacial debonding strength (tau(sub debond)) and frictional sliding stress (tau(sub friction)) in the SCS-6/SAS system were evaluated to be approximately 6.7 +/- 2.3 MPa and 4.3 +/- 0.6 MPa, respectively, indicating a weak interface. However, for the SCS-0/SAS composite, much higher values of approximately 17.5 +/- 2.7 MPa for tau(sub debond) and 11.3 +/- 1.6 MPa for tau(sub friction) respectively, were observed; some of the fibers were so strongly bonded to the matrix that they could not be pushed out. Examination of fracture surfaces revealed limited short pull-out length of SCS-0 fibers. The applicability of various micromechanical models for predicting the values of first matrix cracking stress and ultimate strength of these

  9. Stratospheric Air Sub-sampler (SAS) and its application to analysis of Δ17O(CO2) from small air samples collected with an AirCore

    Science.gov (United States)

    Janina Mrozek, Dorota; van der Veen, Carina; Hofmann, Magdalena E. G.; Chen, Huilin; Kivi, Rigel; Heikkinen, Pauli; Röckmann, Thomas

    2016-11-01

    We present the set-up and a scientific application of the Stratospheric Air Sub-sampler (SAS), a device to collect and to store the vertical profile of air collected with an AirCore (Karion et al., 2010) in numerous sub-samples for later analysis in the laboratory. The SAS described here is a 20 m long 1/4 inch stainless steel tubing that is separated by eleven valves to divide the tubing into 10 identical segments, but it can be easily adapted to collect smaller or larger samples. In the collection phase the SAS is directly connected to the outlet of an optical analyzer that measures the mole fractions of CO2, CH4 and CO from an AirCore sampler. The stratospheric part (or if desired any part of the AirCore air) is then directed through the SAS. When the SAS is filled with the selected air, the valves are closed and the vertical profile is maintained in the different segments of the SAS. The segments can later be analysed to retrieve vertical profiles of other trace gas signatures that require slower instrumentation. As an application, we describe the coupling of the SAS to an analytical system to determine the 17O excess of CO2, which is a tracer for photochemical processing of stratospheric air. For this purpose the analytical system described by Mrozek et al. (2015) was adapted for analysis of air directly from the SAS. The performance of the coupled system is demonstrated for a set of air samples from an AirCore flight in November 2014 near Sodankylä, Finland. The standard error for a 25 mL air sample at stratospheric CO2 mole fraction is 0.56 ‰ (1σ) for δ17O and 0.03 ‰ (1σ) for both δ18O and δ13C. Measured Δ17O(CO2) values show a clear correlation with N2O in agreement with already published data.

  10. DIMG92 : un simulateur de formation pour le procédé DIMERSOL Dimg92: a Training Simulator for the Dimersol Process

    Directory of Open Access Journals (Sweden)

    Nica A.

    2006-11-01

    Full Text Available DIMG92 est un simulateur de formation sur le procédé pétrochimique DIMERSOL (procédé IFP de dimérisation du propylène. En simulant le réacteur et ses équipements annexes, les opérateurs s'exercent à conduire l'unité et comprennent les effets des divers paramètres à prendre en compte. Le simulateur est composé de deux logiciels : - Un logiciel de modélisation, basé sur la représentation mathématique de connaissances physico-chimiques et physiques. Aucun empirisme n'est utilisé dans le modèle. Ce logiciel a été développé par l'Institut Français du Pétrole (IFP. - Un logiciel d'environnement de simulation dynamique pour la formation. Ce logiciel à interface graphique et interactive est distribué par la société française Réalisation en Systémique Industrielle (RSI. Industrial units are tending to become more and more complex and are characterized by a very high degree of integration. The operating of such units requires highly skilled operators. This is why dynamic simulators have training as their prime goal. The DIMG92 simulator falls within this category. It simulates the reaction section of the DIMERSOL G process in a steady state or not. The DIMERSOL G process is designed for the dimerization of propylene into hexene. In the modeled unit, the reaction section includes a liquid-phase reactor and a pump-around on which a heat exchanger is installed. The heat exchanger, which uses water as the cooling fluid, evacuates the heat of reaction. The reaction temperature is between 45 and 55°C. The reactor pressure is in the vicinity of 22 effective bars. The catalyst is in a liquid state. A standard feedstock is made up of 30 weight % inert matter and 70% propylene. Modeling is broken down into three parts : the kinetics, the reactor, the heat exchanger. Mathematical modeling of the oligomerization kinetics was performed at Institut Français du Pétrole (IFP in 1987. By taking into consideration the initiation

  11. Preparation of HA/P(AM-SAS) blend and their inhibition performance of scale and corrosion%改性腐植酸新型阻垢缓蚀剂的制备及应用

    Institute of Scientific and Technical Information of China (English)

    邱广明; 邱广亮

    2001-01-01

    The blends [HA/P(AM-SAS)]of humic acids(HA)and copolymer P(AM-SAS) of acrylamide(AM) and sodium allylsulfonate(SAS) have been prepared by solution blend. Their inhibition performance of scale and corrosion and dispersion performance have been studied and compared with HA and P(AM-SAS). Experimental results indicates that their scale and corrosion inhibition rates and dispersing Fe2O3 capability increase with the increasing of their concentration. Compared with HA and P(AM-SAS),HA/P(AM-SAS)blends have better scale and corrosion inhibition performance and dispersion capability. During the blending of HA and P(AM-SAS),HA and P(AM-SAS)have synergistic effects for CaCO3 and Ca3(PO4)2 scale inhibition when HA/P(AM-SAS)mass ratio is above 1 and 2.Under the condition:ρ(Ca2+)=250 mg/L、ρ(HCO3-)=250 mg/L、ρ(CO32-)=85 mg/L、ρ(PO43-)=5 mg/L、pH=8.5、T=80 ℃、t=10 h,the inhibition rates of HA/P(AM-SAS)blends on the CaCO3 and Ca3(PO4)2 scale are up to 98.9%and 97.2%respectively. When the dosage ofHA/P(AM-SAS)blends is beyond 20 mg/L,the corrosion inhibition rate on mild steel reaches 95.0%.%采用溶液共混技术,制备了腐植酸钠(HA)和丙烯酰胺—烯丙基磺酸钠(SAS)共聚物[P(AM-SAS)]的共混物[HA/P(AM-SAS)],研究了共混物[HA/P(AM-SAS)]的阻垢、缓蚀和分散性能,并与HA和P(AM-SAS)做了对比分析。实验表明,HA/P(AM-SAS)共混物、HA和P(AM-SAS)的阻垢、缓蚀和分散能力随着使用浓度的增加而提高。与HA和P(AM-SAS)相比,HA/P(AM-SAS)共混物具有更好的阻垢、缓蚀和分散能力。当HA/P(AM-SAS)质量比超过1或2时,HA和P(AM-SAS)的共混对于CaCO3和Ca3(PO4)2的阻垢作用表现出了明显的协同效应。当ρ(Ca2+)=250 mg/L、ρ(HCO3-)=250 mg/L、ρ(CO32-)=85 mg/L、ρ(PO43-)=5 mg/L、pH=8.5、T=80 ℃、t=10 h时,HA/P(AM-SAS)共混物对CaCO3和Ca3(PO4)2的阻垢率分别达到了98.9%和97.2%。当HA/P(AM-SAS)共混物的使用浓度超过20 mg/L,共混物

  12. El món de ficció com a clau en el procés d'adaptació: el cas de Blade Runner, el videojoc

    OpenAIRE

    Fernández Vara, Clara

    2016-01-01

    La narratologia tradicional se centra a descriure estructures basades en models lingüístics que compliquen entendre la narrativa en mitjans interactius. No obstant això, basant-nos en teories més recents, com les proposades per Herman a Story Logic (2002), el qual es refereix als storyworlds (mons-història) com l'element central de les narratives, podem ver com els mons de ficció ens serveix tant per entendre les narratives en mitjans interactius com en el procés de translació entre ells. Per...

  13. Development of PCR protocols for specific identification of Clostridium spiroforme and detection of sas and sbs genes.

    Science.gov (United States)

    Drigo, Ilenia; Bacchin, Cosetta; Cocchi, Monia; Bano, Luca; Agnoletti, Fabrizio

    2008-10-15

    Rabbit diarrhoea caused by toxigenic Clostridium spiroforme is responsible for significant losses in commercial rabbitries but the accurate identification of this micro-organism is difficult due to the absence of both a commercial biochemical panel and biomolecular methods. The aim of this study was therefore to develop PCR protocols for specific detection of C. spiroforme and its binary toxin encoding genes. The C. spiroforme specie-specific primers were designed based on its 16S rDNA published sequences and the specificity of these primers was tested with DNA extracted from closely related Clostridium species. The sa/bs_F and sa/bs _R C. spiroforme binary toxin specific primers were designed to be complementary, respectively, to a sequence of 21 bases on the 3' and of sas gene and on the 5' of the sbs gene. The detection limits of in house developed PCR protocols were 25CFU/ml of bacterial suspension and 1.38x10(4)CFU/g of caecal content for specie-specific primers and 80CFU/ml of bacterial suspension and 2.8x10(4)CFU/g of caecal content in case of sa/bs primers. These results indicated that the described PCR assays enable specific identification of C. spiroforme and its binary toxin genes and can therefore be considered a rapid, reliable tool for the diagnosis of C. spiroforme-related enterotoxaemia.

  14. NParCov3: A SAS/IML Macro for Nonparametric Randomization-Based Analysis of Covariance

    Directory of Open Access Journals (Sweden)

    Richard C. Zink

    2012-07-01

    Full Text Available Analysis of covariance serves two important purposes in a randomized clinical trial. First, there is a reduction of variance for the treatment effect which provides more powerful statistical tests and more precise confidence intervals. Second, it provides estimates of the treatment effect which are adjusted for random imbalances of covariates between the treatment groups. The nonparametric analysis of covariance method of Koch, Tangen, Jung, and Amara (1998 defines a very general methodology using weighted least-squares to generate covariate-adjusted treatment effects with minimal assumptions. This methodology is general in its applicability to a variety of outcomes, whether continuous, binary, ordinal, incidence density or time-to-event. Further, its use has been illustrated in many clinical trial settings, such as multi-center, dose-response and non-inferiority trials.NParCov3 is a SAS/IML macro written to conduct the nonparametric randomization-based covariance analyses of Koch et al. (1998. The software can analyze a variety of outcomes and can account for stratification. Data from multiple clinical trials will be used for illustration.

  15. SNP_NLMM: A SAS Macro to Implement a Flexible Random Effects Density for Generalized Linear and Nonlinear Mixed Models.

    Science.gov (United States)

    Vock, David M; Davidian, Marie; Tsiatis, Anastasios A

    2014-01-01

    Generalized linear and nonlinear mixed models (GMMMs and NLMMs) are commonly used to represent non-Gaussian or nonlinear longitudinal or clustered data. A common assumption is that the random effects are Gaussian. However, this assumption may be unrealistic in some applications, and misspecification of the random effects density may lead to maximum likelihood parameter estimators that are inconsistent, biased, and inefficient. Because testing if the random effects are Gaussian is difficult, previous research has recommended using a flexible random effects density. However, computational limitations have precluded widespread use of flexible random effects densities for GLMMs and NLMMs. We develop a SAS macro, SNP_NLMM, that overcomes the computational challenges to fit GLMMs and NLMMs where the random effects are assumed to follow a smooth density that can be represented by the seminonparametric formulation proposed by Gallant and Nychka (1987). The macro is flexible enough to allow for any density of the response conditional on the random effects and any nonlinear mean trajectory. We demonstrate the SNP_NLMM macro on a GLMM of the disease progression of toenail infection and on a NLMM of intravenous drug concentration over time.

  16. Supplier Assessment System (SAS)

    Science.gov (United States)

    Dietrich, Kristen

    2016-01-01

    Background: Sponsored by NASA Headquarters; Charter - provide information to assist the quality assurance community in evaluating and determining supplier risk; Comprehensive on-line repository of supplier information; Available to approved civil service personnel from all NASA Centers, other U.S. Government Agencies, Prime Contractors, and NASA direct support contractors; User access to specific data types or documents is controlled as needed.

  17. Sustainable Ammunition Safety (SAS)

    NARCIS (Netherlands)

    Klerk, W.P.C. de; Hooijmeijer, P.; Harmelen, P. van

    2014-01-01

    In the Netherlands, no national industry in the field of energetic materials / ammunition for military applications is available. The knowledge of explosives, ammunition and ammunition on the vulnerability of platforms is limited, first to Defence regarding the logistical and operational practice an

  18. Can the Immune System Perform a t-Test?

    Science.gov (United States)

    Faria, Bruno Filipe; Mostardinha, Patricia

    2017-01-01

    The self-nonself discrimination hypothesis remains a landmark concept in immunology. It proposes that tolerance breaks down in the presence of nonself antigens. In strike contrast, in statistics, occurrence of nonself elements in a sample (i.e., outliers) is not obligatory to violate the null hypothesis. Very often, what is crucial is the combination of (self) elements in a sample. The two views on how to detect a change seem challengingly different and it could seem difficult to conceive how immunological cellular interactions could trigger responses with a precision comparable to some statistical tests. Here it is shown that frustrated cellular interactions reconcile the two views within a plausible immunological setting. It is proposed that the adaptive immune system can be promptly activated either when nonself ligands are detected or self-ligands occur in abnormal combinations. In particular we show that cellular populations behaving in this way could perform location statistical tests, with performances comparable to t or KS tests, or even more general data mining tests such as support vector machines or random forests. In more general terms, this work claims that plausible immunological models should provide accurate detection mechanisms for host protection and, furthermore, that investigation on mechanisms leading to improved detection in “in silico” models can help unveil how the real immune system works. PMID:28046042

  19. Saksa telekanal näitab filmi Tättest

    Index Scriptorium Estoniae

    2006-01-01

    Saksa telekanalis NDR esilinastub täna Eestist kõnelev loodusfilm, mille stsenarist ja režissöör on Urmas E: Liiv, muusika autor Ardo-Ran Varres, tekst on Jaan Tättelt, operaator Maris Maskalams, tootja Valdis Abols Lätist

  20. Evaluation of the Potential Application on the Wag Process in a North Sea Reservoir Evaluation de l'utilisation potentielle du procédé WAG dans un gisement de mer du Nord

    Directory of Open Access Journals (Sweden)

    Stensen J. A.

    2006-11-01

    Full Text Available The paper discusses the potential increase in oil recovery due to injection of water alternating gas (WAG. The WAG process is compared to waterflooding and gas injection. The mechanisms of the WAG process which makes the process interesting for a North Sea reservoir are discussed. The application of a WAG scheme is discussed with regard to the field restrictions and possibilities of Norwegian reservoirs. The WAG process is found to improve the oil recovery primarily due to improved vertical sweep efficiency. Cross-sectional models have been used to study the sensitivity to variations in vertical permeability. The paper also reports results of multi-phase displacement experiments using sequences of gas and water injections. The oil recovery by primary and secondary injection of both gas and water have been measured both on Berea sandstone cores and sandstone reservoir cores. The measurements include experiments at realistic reservoir conditions using reservoir fluids, and also series of experiments performed at reduced pressure and temperature utilising model fluids. Cette communication envisage l'accroissement potentiel de la récupération de pétrole par le procédé WAG d'injection alternée d'eau et de gaz. Le procédé WAG est comparé ici à l'injection de gaz et à l'injection d'eau. Les mécanismes qui rendent intéressant le procédé WAG pour un gisement de mer du Nord font l'objet d'une discussion. L'application du procédé WAG est envisagée en fonction des limitations et des possibilités des gisements norvégiens ; On constate que le procédé WAG améliore la récupération de pétrole, surtout du fait d'une meilleure efficacité verticale de balayage. Des modèles en coupe ont été utilisés pour étudier la sensibilité aux variations de la perméabilité verticale. Cette communication rapporte également les résultats d'expériences de déplacement multi-phases avec injections alternées d'eau et de gaz. La récupération de

  1. Enregistrements, procès-verbaux, transcriptions devant la Commission d’enquête : le traitement de l’oral en questions Recordings, official reports, transcriptions before the Inquiry committee: questioning the treatment of orality

    Directory of Open Access Journals (Sweden)

    Evelyne Serverin

    2009-02-01

    Full Text Available Nombre d’observations formulées devant la Commission d’enquête sur l’affaire dite d’Outreau, et nombre de préconisations ont porté sur les procédés employés pour consigner les déclarations des personnes entendues au cours d’une procédure pénale. Le passage de l’oral à l’écrit a été abordé sous deux dimensions : 1 la première dimension est institutionnelle et pose la question de l’incidence du droit processuel sur les événements rapportés devant la Commission d’enquête. Il est apparu que si l’enregistrement des auditions des enfants était obligatoire, les moyens légaux d’y échapper étaient multiples, de sorte que les procès-verbaux sont restés la référence exclusive dans le cours de l’instruction ; 2 la deuxième dimension est linguistique, et concerne les problèmes de la transcription de l’oral en interaction. Les écarts entre les enregistrements vidéos réalisés devant la Commission d’enquête et leurs transcriptions dans le rapport final montrent qu’un procès-verbal, rédigé dans le cours même d’une audition, ne peut restituer ni la teneur ni le déroulement des propos échangés. Le visionnage s’impose donc pour guider les problèmes d’interprétation. En l’absence de réforme profonde du statut de l’oral dans la procédure pénale, force est de conclure qu’une affaire comme celle d’Outreau a toutes les chances de se reproduire.Many observations formulated before the Investigation Committee on the Outreau case and many recommendations have concerned the devices used to record the declarations of the persons heard during the criminal proceedings. The transformation of the oral into written declarations is considered from two dimensions: 1 the first dimension is institutional and raises the question of the impact of criminal procedure law on the events reported before the Investigation Committee. It has appeared that if registering the hearings of the children is

  2. From Uhuru at CfA to SAS-3 at MIT: Looking for X-Ray Binaries in all the Right Places

    Science.gov (United States)

    Cominsky, Lynn R.

    2013-01-01

    My career in X-ray astronomy started almost accidentally, when in 1975 I was hired fresh out of college as a “data aide” for the Uhuru satellite, in Riccardo Giacconi’s group at the Harvard-Smithsonian Center for Astrophysics. Working first for Mel Ulmer, and later for Bill Forman and Christine Jones, I learned the fundamentals of data analysis, and helped produce the Fourth Uhuru catalog of X-ray sources (Forman et al. 1978), as well as studying transient X-ray sources (Cominsky et al. 1978). Christine was the first woman scientist I had ever met, and with her encouragement, I applied to graduate school to continue on in X-ray astronomy. Lured down the street to MIT by the chance to work on SAS-3, I eagerly learned how to operate the satellite from a control room in the Center for Space Research. The SAS-3 group was led by Prof. George Clark, and it was my good luck that he was around during the holiday break in January 1978 when everyone else in the group was at an AAS meeting in Hawaii. A source I recognized from my Uhuru work, 4U0115+63, had reappeared, and I knew that it was likely to be a pulsar. With the help of George and Project Scientist Bill Mayer, I managed to send the commands to stop SAS-3 and point at the source. The 3.6 second pulsations were so strong that they could be seen in the raw data! This discovery made the New York Times, as 4U0115+63 was the first transient x-ray source shown to be in a binary system (Cominsky et al. 1978, Rappaport et al. 1978). Another personal SAS-3 highlight included working on Prof. Walter Lewin’s “World-wide Burst Watch” - coordinated multi-wavelength observations of x-ray burst sources which led to the discoveries of slightly delayed but coincident optical bursts (Grindlay et al. 1978, McClintock et al. 1979). Although live operations of SAS-3 ended when it re-entered on April 9, 1979, many years of additional data analysis remained. And later, as a continuation of work I began in my Ph.D. Thesis on X

  3. SAS implementation of the multi index panel data clustering%多指标面板数据聚类的 SAS实现

    Institute of Scientific and Technical Information of China (English)

    姜超

    2013-01-01

    基于多指标面板数据聚类的理论,以全国31个省市的城市化水平为例,介绍利用SAS编程实现此聚类方法的过程,结果表明,该SAS程序显示了良好的应用性,为多指标面板数据聚类的实现提供了参考和依据。%Multi index panel data clustering based on the theory of the city,the 31 provinces and municipalities level as an example,intro-duces the process,the clustering method by using SAS program shows that,the SAS program shows good application,provides the reference and the basis for the realization of multi index panel data clustering.

  4. The Application of the SAS Software in Chemical Education%SAS统计软件在化学教育上的应用

    Institute of Scientific and Technical Information of China (English)

    王琴

    2007-01-01

    报道了SAS(统计分析系统)软件的特点.列举了一些在化学教育研究中使用SAS软件应用的实例.这一软件可实现化学、数学和计算机技术的良好结合,SAS软件已在化学教育和科研中获得了广泛应用.

  5. Small-angle scattering computed tomography (SAS-CT) using a Talbot-Lau interferometerand a rotating anode x-ray tube:theory and experiments.

    Science.gov (United States)

    Chen, Guang-Hong; Bevins, Nicholas; Zambelli, Joseph; Qi, Zhihua

    2010-06-01

    X-ray differential phase contrast imaging methods, including projection imaging and the corresponding computed tomography (CT), have been implemented using a Talbot interferometer and either a synchrotron beam line or a low brilliance x-ray source generated by a stationary-anode x-ray tube. From small-angle scattering events which occur as an x-ray propagates through a medium, a signal intensity loss can be recorded and analyzed for an understanding of the micro-structures in an image object. This has been demonstrated using a Talbot-Lau interferometer and a stationary-anode x-ray tube. In this paper, theoretical principles and an experimental implementation of the corresponding CT imaging method are presented. First, a line integral is derived from analyzing the cross section of the small-angle scattering events. This method is referred to as small-angle scattering computed tomography (SAS-CT). Next, a Talbot-Lau interferometer and a rotating-anode x-ray tube were used to implement SAS-CT. A physical phantom and human breast tissue sample were used to demonstrate the reconstructed SAS-CT image volumes.

  6. Studies on prevalence of biofilm associated genes and primary observation on sasX gene in clinical isolates of coagulase negative staphylococci (CoNS).

    Science.gov (United States)

    Soumya, Kandammuriyil Radhakrishnan; Mathew, Shiji; Sugathan, Sheela; Mathew, Jyothis; Radhakrishnan, Edayileveettil Krishnankutty

    2016-04-01

    Coagulase negative staphylococci (CoNS) are nosocomial pathogens that cause indwelling medical device associated infections due to its biofilm forming potential and multiple antibiotic resistance. The current study focused on species identification, antibiotic resistance profile and molecular basis of biofilm formation and attachment of CoNS isolated from clinical samples. Along with this, molecular screening for mecA and newly identified surface colonization protein encoded by sasX gene was also conducted. S. epidermidis (n = 19, 47%) was identified as the most prevalent CoNS species and very interestingly two biofilm forming, mecA positive S. epidermidis isolates were found to carry all the biofilm associated genes screened in this study, which indicates its potential to form the strong biofilm. Another novel observation of the study is the detection of sasX gene in one biofilm positive S. epidermidis isolate. The study also identified one doxycycline resistant mecA positive, multidrug resistant S. haemolyticus isolate. In conclusion, the study signifies the existence of multiple biofilm related genes, multidrug resistance and the presence of sasX gene among clinical isolates of CoNS.

  7. On Teaching Problems about Medical Statistics SAS Experimental Courses%医学统计学SAS实验课程相关教学问题探讨

    Institute of Scientific and Technical Information of China (English)

    汤在祥

    2012-01-01

    SAS软件实验课是医学统计学的重要课程,上好SAS软件实验课对于学生掌握和应用统计学方法具有重要实践意义。针对医学统计学SAS软件实验课特点,以及当前教学过程中存在的问题,对SAS软件实验课了提出了几点探讨,为提高医学院校SAS软件实验课的教学效果提供参考。%SAS software experimental course is an important course about medical statistics, which is of great significance for students to master and apply the statistical method. According to characteristics of medical statistics SAS software, as well as problems in the educational process, the paper discusses the experimental course and hopes to improve the teach-ing effect of the SAS software.

  8. Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways.

    Science.gov (United States)

    Lai, Wan-Wen; Hsu, Shu-Chun; Chueh, Fu-Shih; Chen, Ya-Yin; Yang, Jai-Sing; Lin, Jing-Pin; Lien, Jin-Cherng; Tsai, Chung-Hung; Chung, Jing-Gung

    2013-05-01

    Quercetin, a principal flavanoid compound in onions, has been shown to possess a wide spectrum of pharmacological properties, including anticancer activities. Our earlier study showed that quercetin induced cytotoxic effects on SAS human oral cancer cells. In this study, we found that quercetin significantly reduced wound closure of SAS cells in culture plates after 12- and 24-h treatments. Results indicated that quercetin inhibited the expression and activity of matrix metalloproteinase (MMP)-2 and MMP-9, as measured by western blotting and gelatin zymography. The results from western blotting also showed that quercetin reduced the protein levels of MMP-2, -7, -9 and -10, vascular endothelial growth factor (VEGF), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) p65, inductible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), urokinase-type plasminogen activator (uPA), phosphatidylinositide-3 kinases (PI3K), nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IKBα), IKB-α/β, phosphorylated nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor kinase, alpha/beta (p-IKKα/β), focal adhesion kinase (FAK), son of sevenless homolog-1 (SOS1), growth factor receptor-bound protein-2 (GRB2), mitogen-activated protein kinase kinase kinase-3 (MEKK3), MEKK7, extracellular-signal-regulated kinase 1/2 (ERK1/2), p-ERK1/2, c-Jun N-terminal kinase 1/2 (JNK1/2), p38, p-p38, Jun proto-oncogene (c-JUN) and p-c-JUN but it did not affect Ras homolog gene family, member A (RhoA), Protein kinase C (PKC) and rat sarcoma viral oncogene homolog (RAS) in SAS cells. Confocal laser microscopy also showed that quercetin promoted the expressions of RhoA and Rho-associated, coiled-coil containing protein kinase-1 (ROCK1), but inhibited the expression of NF-κB p65 in SAS cells. It is concluded from these data that inhibition of migration and invasion of SAS cells by quercetin is associated with the down

  9. Protocolo de Observação Comportamental - PROC: valores de referência para uma análise quantitativa Behavioral Observation Protocol: reference values for a quantitative analysis

    Directory of Open Access Journals (Sweden)

    Simone Rocha de Vasconcellos Hage

    2012-08-01

    Full Text Available OBJETIVO: obter valores de referência para protocolo de observação comportamental (PROC sobre o desenvolvimento de habilidades comunicativas e de esquemas simbólicos em crianças com desenvolvimento típico de linguagem. MÉTODO: foram avaliadas 44 crianças entre 24 e 47 meses de ambos os gêneros, selecionadas em escolas de educação infantil, por meio de triagem do desenvolvimento global Denver II e questionário com os pais. Todas as crianças foram filmadas durante 30 minutos em interação com um adulto em atividade envolvendo brinquedos. As gravações foram analisadas por meio do PROC. A análise estatística descreveu valores de média, mediana, valores mínimos e máximos. Foi utilizado o teste T de Student para comparação das idades. RESULTADOS: nas habilidades comunicativas, as crianças do estudo mostraram evolução com a idade (média para três e dois anos, respectivamente: 58,12 e 51,44, apesar de não ter sido encontrada diferença estatisticamente significante para as faixas etárias comparadas (p=0,486. Quanto ao item compreensão verbal, as crianças de três anos obtiveram melhor desempenho que as de dois (respectivas médias: 59,41 e 50,70, havendo diferença estatisticamente significante (p=0,0000020. Em relação ao item aspectos do desenvolvimento cognitivo, as crianças de três anos apresentaram melhor desempenho em comparação com as de dois (respectivas médias: 44,53 e 31,96, havendo diferença estatisticamente significante entre as pontuações obtidas (p=0,00364, mostrando que as crianças evoluem na hierarquia do simbolismo. CONCLUSÃO: a obtenção de valores de referência para o PROC veio combinar análise qualitativa e quantitativa, contribuindo, além do diagnóstico, para o acompanhamento objetivo de processos terapêuticos.PURPOSE: to obtain reference values for behavioral observation protocol on the development of communicative and symbolic schemes of children with typical language development

  10. Généralisation d'une approche de conception de procédés de distillation réactive : application à la production d'hydrogène par le cycle thermochimique I-S.

    OpenAIRE

    Belaissaoui, Bouchra

    2006-01-01

    La distillation réactive constitue une voie de production prometteuse pour améliorer les procédés conventionnels. Cependant les méthodes, outils et applications proposés dans la littérature se limitent aux systèmes réactifs en phase liquide. L'objectif majeur des travaux est ainsi de généraliser l'approche de conception séquentielle et hiérarchisée proposée par R. Théry (2002). Au niveau des outils, un modèle mathématique général de condensation et d'évaporation ouvertes de systèmes réactifs ...

  11. Etudes fondamentales et développement de procédés innovants pour l'élimination biologique de l'azote et du phosphore dans des effluents d'abattoir

    OpenAIRE

    Lemaire, Romain

    2007-01-01

    L’industrie de la viande utilise de larges quantités d’eau lors de l’abattage, du découpage et du nettoyage des équipements. Les effluents produits sont très chargés en DCO, azote et phosphore. Afin d’éviter toute pollution des milieux aquatiques environnants, ces effluents doivent subir des traitements poussés. Le but principal de cette thèse était de développer un procédé de traitement par boues activées qui puisse éliminer plus de 95% de la DCO, de l’azote et du phosphore dans les effluent...

  12. Le procès de Tôkyô et le débat sur l’Histoire de Shôwa The Tokyo trial and the History of Shôwa

    Directory of Open Access Journals (Sweden)

    Tristan Brunet

    2010-07-01

    Full Text Available Paru en 1955, l’Histoire de Shôwa représente l’exemple le plus représentatif du projet des historiens japonais pour élaborer, au lendemain de la Seconde Guerre mondiale, une nouvelle histoire nationale. Le but avoué des auteurs est de dépasser les limites du procès de Tôkyô, et la menace que celles-ci font peser à leurs yeux sur la démocratie au Japon. L’ouvrage fait l’objet d’une polémique qui permet de mesurer les résistances qui se développent au sein de la société japonaise contre un tel projet. Cet article cherche à souligner les enjeux politiques et mémoriels qui entourent le débat, particulièrement en ce qui concerne la question centrale des responsabilités de guerre, et par conséquent du traitement réservé dans cette histoire au procès de Tôkyô.Published in 1955, the History of Shôwa is the most prominent example of the project by Japanese academic historians to elaborate a new national history, in the aftermath of the Second World War. Their intended goal was to exceed the limits of the Tokyo trial, and the threat those limits put, according to the authors, on the Japanese democracy. A polemic took place after the publication of the book, which allows us to acknowledge the growing resistance within Japanese society against such a project. This paper will try to underline the political and memorial stakes behind this debate, especially in relation to the responsibilities of war, and consequently the depiction of the Tokyo trial in such an history.

  13. SAS продаёт свою долю Estonian Air / Герт Д. Ханкевиц

    Index Scriptorium Estoniae

    Ханкевиц, Герт Д.

    2009-01-01

    Majandusraskustes lennufirma SAS kavatseb loobuda osalustest kõigis lennufirmades, mis ei sobi kokku nende uue tegevuskavaga. Majandus- ja kommunikatsiooniminister Juhan Parts arvab, et riik peaks leidma Estonian Airile kodumaised partnerid

  14. Assessment of SFR reactor safety issues: Part II: Analysis results of ULOF transients imposed on a variety of different innovative core designs with SAS-SFR

    Energy Technology Data Exchange (ETDEWEB)

    Kruessmann, R., E-mail: regina.kruessmann@kit.edu [Karlsruhe Institute of Technology, Institute of Neutron Physics and Reactor Technology INR, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Ponomarev, A.; Pfrang, W.; Struwe, D. [Karlsruhe Institute of Technology, Institute of Neutron Physics and Reactor Technology INR, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Champigny, J.; Carluec, B. [AREVA, 10, rue J. Récamier, 69456 Lyon Cedex 06 (France); Schmitt, D.; Verwaerde, D. [EDF R& D, 1 avenue du général de Gaulle, 92140 Clamart (France)

    2015-04-15

    Highlights: • Comparison of different core designs for a sodium-cooled fast reactor. • Safety assessment with the code system SAS-SFR. • Unprotected Loss of Flow (ULOF) scenario. • Sodium boiling and core melting cannot be avoided. • A net negative Na void effect provides more grace time prior to local SA destruction. - Abstract: In the framework of cooperation agreements between KIT-INR and AREVA SAS NP as well as between KIT-INR and EDF R&D in the years 2008–2013, the evaluation of severe transient behavior in sodium-cooled fast reactors (SFRs) was investigated. In Part I of this contribution, the efficiency of newly conceived prevention and mitigation measures was investigated for unprotected loss-of-flow (ULOF), unprotected loss-of-heat-sink (ULOHS) and the unprotected transient-overpower (UTOP) transients. In this second part, consequence analyses were performed for the initiation phase of different unprotected loss-of-flow (ULOF) scenarios imposed on a variety of different core design options of SFRs. The code system SAS-SFR was used for this purpose. Results of analyses for cases postulating unavailability of prevention measures as shut-down systems, passive and/or active additional devices show that entering into an energetic power excursion as a consequence of the initiation phase of a ULOF cannot be avoided for those core designs with a cumulative void reactivity feedback larger than zero. However, even for core designs aiming at values of the void reactivity less than zero it is difficult to find system design characteristics which prevent the transient entering into partial core destruction. Further studies of the transient core and system behavior would require codes dedicated to specific aspects of transition phase analyses and of in-vessel material relocation analyses.

  15. Los efectivos del último ejército de la Persia Sasánida (572-642. Una solución desde las fuentes

    Directory of Open Access Journals (Sweden)

    Soto Chica, José

    2015-12-01

    Full Text Available The question of the number of troops that existed in the Sassanids’ armies during the 6th and 7th century has received various answers. Answers that, paradoxically, have not taken into account the specific and multiple information that provide the sources of this period. From our side in this paper, we address this question taking into account all the sources, whether these are Byzantine, Oriental, Persian or Perso-Islamic, and we try to show that the careful study of the data and the critical comparison permits us to evaluate with extreme precision the military power of the Sassanian Persia and to establish a comparative basis to shed new light on the late conflicts between Sassanid Persia and the Justinian’s or Heraclius’ Byzantium as well as those with the Arab armies of early Islam.La cuestión del número de efectivos con que contaron los ejércitos sasánidas de los siglos VI y VII ha recibido diferentes respuestas. Respuestas que, paradójicamente, no han tenido en cuenta las precisas y múltiples informaciones que al respecto proporcionan las fuentes del periodo. Por nuestra parte y en este trabajo, abordamos dicha cuestión teniendo en cuenta la totalidad de las fuentes, ya sean estas bizantinas, orientales, persas o persoislámicas y tratamos de mostrar que el atento estudio de los datos y su confrontación crítica, permite evaluar con suma precisión el poderío militar de la Persia sasánida y establecer así una base comparativa que arroje nueva luz sobre los últimos conflictos de la Persia sasánida con el Bizancio Justinianeo y Heraclida y con los ejércitos árabes del primer Islam.

  16. Inorganic Species Behaviour in Thermochemical Processes for Energy Biomass Valorisation Comportement des espèces inorganiques dans les procédés thermochimiques de valorisation énergétique de la biomasse

    Directory of Open Access Journals (Sweden)

    Froment K.

    2013-09-01

    difficulties (corrosion, fouling, etc.: a detailed summary of the specific behaviour of the inorganic compounds in biomass thermal conversion facilities will be given, going from the description of inorganic species included in biomass up to the prevention and the solution, as far as possible. The following topics will therefore be developed: inventory of inorganic species in different biomasses; general review of the inorganic speciation during thermal conversion processes; technological barriers to overcome for economic and technological process improvements; specific aspects related to inorganic species behaviour investigated at CEA: inorganic species release and condensation; aerosol behaviour and deposits; hot particles filtration; slag formation and interactions with reactor wall. Les espèces inorganiques de la biomasse (bois, déchets agricoles, déchets ménagers voire boues d’épuration présentent un large spectre en compositions et quantités, dépendant de l’origine de la biomasse (nature, lieux et conditions de sa croissance, etc.. Les différents procédés de conversion (combustion, pyrolyse, gazéification, etc. et les différentes technologies associées (fours à grille, lits fixes ou fluidisés, réacteurs à flux entraînés, etc. utilisant l’énergie de la biomasse, fournissent des conditions opératoires très variées en atmosphère, température, pression, etc. Au cours de chacun de ces procédés thermiques de conversion, en fonction de la composition initiale de la biomasse, de l’atmosphère et la température du procédé (la pression est un paramètre de second ordre par rapport aux précédents, certaines espèces inorganiques réagissent pour former des composés liquides ou gazeux, seuls ou combinés à d’autres espèces : celles-ci peuvent être soit piégées à différents endroits dans le procédé, soit relâchées avec le gaz. Les interactions potentielles de ces espèces inorganiques avec les parois des réacteurs, les mat

  17. Smart substation is the further objective of SAS%智能变电站是变电站综合自动化的发展目标

    Institute of Scientific and Technical Information of China (English)

    黄益庄

    2013-01-01

    The main principle and idea of determining a development goal is proposed. Based on the development tendency of power network at home and abroad, the concept of “Smart Substation” is considered as the higher stage and further objective of technological development of SAS. The key point for “Smart Substation” lies in “intelligence”, i.e., to intelligentize different kinds of equipments in the substation. It should be a qualitative leap based on the realized functions of SAS. In smart substation, more attention should be paid on the technologies of switching on the distributed generation and realizing two-way interaction. The safety strategy of information management and storage is specially noticed. Many complicated key technologies need to be studied. Anyway,“Smart Substation” is a comprehensive system engineering. It is necessary to set a long term construction goal and planning.%  提出了确定建设目标需要考虑的主要原则和理念。根据国内外电网技术发展的趋势,论述了“智能变电站”是 SAS 技术发展的高级阶段和进一步发展的目标。“智能变电站”需要立足于一次和二次设备都实现智能化,必须在 SAS 已实现的功能的基础上有质的飞跃和扩展。对目前关于“智能变电站”建设过程中流传的一些模糊认识进行澄清。指出建设“智能变电站”有许多复杂的关键技术尚待解决,要充分重视分布式电源接入电网的相关技术的研究、要注意电力信息的科学管理和存储的安全策略等问题,是一项综合性、多学科的系统工程,需要制定长期发展的建设目标和规划。

  18. La SAS unipersonal y la empresa unipersonal de responsabilidad limitada-similitudes, diferencias, ventajas y proyección de ambas figuras dentro del ordenamiento mercantil colombiano

    OpenAIRE

    Adriana López

    2012-01-01

    La investigación consta de dos partes. La primera describe el marco regulatorio general de la Empresa Unipersonal y de la Sociedad por Acciones Simplificada (SAS) Unipersonal dentro del ordenamiento jurídico colombiano, haciendo énfasis en las similitudes, diferencias y ventajas de una figura sobre la otra, y la segunda parte hace una proyección de ambas figuras dentro del ordenamiento colombiano con base en las características, similitudes, diferencias y ventajas de la una sobre la otra, par...

  19. Planteamiento estratégico de Pronalfo S.A.S. y Reingeniería del Proceso de Producción

    OpenAIRE

    Fajardo Castillo, Erika Esperanza; Quiroga Arguello, Luz Andrea

    2012-01-01

    Pronalfo S.A.S es una empresa dedicada a la elaboración de núcleos balanceados como materia prima para la alimentación animal, fue creada hace 7 años y se encuentra en la etapa de crecimiento y posicionamiento en el mercado. Es necesario establecer el planeamiento estratégico mediante la definición de misión, visión, objetivos y estrategias, para tener clara su razón de ser y proyectándose al futuro estableciendo una ventaja competitiva mediante estrategias que le permitan mantenerse en ...

  20. Estudio de factibilidad para la prestación de asistencia técnica integral a motos en el Diagnosticentro S.A.S.

    OpenAIRE

    Acosta Chamorro, Darío Fernando

    2015-01-01

    El objetivo del presente trabajo es realizar una evaluación sobre la factibilidad de crear una nueva línea de negocio de asistencia técnica integral para motos en la empresa Diagnosticentro S.A.S., ubicada en la ciudad de Pereira -- Para ello se utiliza la metodología del modelo ONUDI, estableciendo una guía detallada acerca del proceso de planeación, que incluye: estudio del entorno mundial, nacional y local, estudio de mercado, técnico y administrativo, estudio legal y ambiental y evaluació...

  1. Procès inquisitorial contra el castellà d'Amposta Fra Pedro Roiç de Moros a la cúria pontificia del papa Benet XIII (I414-1418

    Directory of Open Access Journals (Sweden)

    Alanyà i Roig, Josep

    2002-06-01

    Full Text Available The Arxiu de la Corona d'Aragó in Barcelona houses the original commital proceedings instituted by a court of cardinals set up by pope Benedict XIII in the year 1414 and teh trial itself of the lord of Amposta, Fra Pedro Roiç de Moros, knight of the Order of St. John of Jerusalem, who had been charged with indictable offences—concubinage, robbery, housing apostates, oath breaking and counterfeiting money, mismanagement of the Castlery's assets, excesses against his vassals, wasteful use of assets, dereliction and property abandonment— of which he was found guilty, and thereafter sentenced to losing the dignity of his lordship. Roiç de Moros appealed to the Council of Constance as well as to pope Martin V. It would be to no avail. Roiç de Moros paid a very high price for choosing to support count Jaume d'Urgell and deciding to oppose Ferran dAntequera and the policies of pope Benedict XIII. The follow up and analysis of the court´s records are very interesting for their human variety and interesting informations about fortresses, houses, barns, treaures and services there were in different locations of the Castlery of Amposta, such as Batea, Gandesa, Miravet, Ulldecona, Ascó and other towns and villages along the Ribera d´Ebre. The whole criminal prosecution bears a very peculiar historic interest mainly because the protagonists, the court procedures, and their causes are the link between the Interregnum in the Aragonese Crown and the fìnal days of the Western Schism.

    A l'Arxiu de la Corona d'Aragó de Barcelona es conserva el procés original instruït per un tribunal de cardenals creat pel papa Benet XIII l'any 1414 per jutjar el Castella d'Amposta, l'hospitaler Fra Pedro Roiç de Moros, acusat de crims greus —concubinat, bandositats, recepció d’apòstates, perjuri i fabricació de moneda falsa, mala administració dels bens de la Castellania, comissió d'excessos contra els seus vassalls, dilapidado de bens i abando

  2. Le procédé de blanchiment dans les ateliers monétaires français au XV-XVIème siècle: approche archéométrique et expérimentale

    Directory of Open Access Journals (Sweden)

    Téreygeol, Florian

    2011-12-01

    Full Text Available In the late nineties, excavations in La Rochelle (France have discovered the remains of a royal mint of the sixteenth century. This discovery enabled the collection of artefacts directly related to the manufacture of coins. The exceptional corpus gathered is the subject of a study of the chaîne opératoire of coining in the medieval time. Special attention is paid to an operation which takes place before the strike: the blanching of blanks. Well documented in ancient times, the samples from La Rochelle offer the opportunity to study this process during the medieval period and in a royal mint. In addition, thanks to reconstitution experiments, it is possible to define a reaction mechanism that helps to understand our historical observations.[fr] À la fin des années quatre-vingtdix, des fouilles menées à La Rochelle (France ont permis de mettre au jour les vestiges d’un atelier monétaire royal du XVIe siècle. Cette découverte a permis la collecte de matériel directement liée à la fabrication monétaire. Le corpus exceptionnel rassemblé est l’objet d’une étude qui vise à mettre en évidence la chaîne opératoire de fabrication de monnaie à l’époque considérée. Un intérêt particulier est porté à une technique d’argenture qui intervient avant la frappe des monnaies, le blanchiment des flans. Bien documenté pour les périodes antiques, le matériel de La Rochelle offre la possibilité de mettre en évidence ce procédé pour une période plus récente et dans un cadre officiel. De plus, à partir d’expériences de reconstitution, il a été possible de proposer un mécanisme réactionnel. Les hypothèses proposées permettent alors de dégager des implications historiques dans le procédé de fabrication.

  3. STUDIES ON HIBISCUS CANNABINUS, HIBISCUS SABDARIFFA, AND CANNABINUS SATIVA PULP TO BE A SUBSTITUTE FOR SOFTWOOD PULP- PART 2: SAS-AQ AND NSSC-AQ DELIGNIFICATION PROCESSES

    Directory of Open Access Journals (Sweden)

    Dharm Dutt

    2010-08-01

    Full Text Available Hibiscus cannabinus, Cannabis sativa, and Hibiscus sabdariffa, fast growing productive annual plants, could provide fiber necessary to partially alleviate the world’s fiber deficit. The present study aimed at producing high yield pulp and the best mechanical strength properties with minimum impact on environment by SAS-AQ, and NSSC-AQ pulping processes. A total alkali of 13% (as Na2O, an alkali ratio of 0.80, and a Na2SO3 charge 11.70% (as Na2O were found optimum to reduce maximum kappa number. A lower kappa number and good strength properties were achieved by increasing total alkali and Na2SO3 charge. SAS-AQ pulps showed good response towards CEHH bleaching. The NSSC-AQ pulping was conducted at a total alkali charge of 8% (as Na2O by varying the ratio of sulphite-to-carbonate (100:0-0:100, and cooking time (60-120 min at 1600C. A ratio of sulphite-to-carbonate 60:40 was suitable for corrugating medium (cooking time 60 min, while a ratio of sulphite-to-carbonate 70:30 showed better strength properties (longer cooking time.

  4. La SAS unipersonal y la empresa unipersonal de responsabilidad limitada-similitudes, diferencias, ventajas y proyección de ambas figuras dentro del ordenamiento mercantil colombiano

    Directory of Open Access Journals (Sweden)

    Adriana López

    2012-07-01

    Full Text Available La investigación consta de dos partes. La primera describe el marco regulatorio general de la Empresa Unipersonal y de la Sociedad por Acciones Simplificada (SAS Unipersonal dentro del ordenamiento jurídico colombiano, haciendo énfasis en las similitudes, diferencias y ventajas de una figura sobre la otra, y la segunda parte hace una proyección de ambas figuras dentro del ordenamiento colombiano con base en las características, similitudes, diferencias y ventajas de la una sobre la otra, para llegar a la conclusión de que la utilización de la empresa unipersonal disminuirá progresivamente hasta desaparecer de la práctica jurídica colombiana, para ser remplazada por la utilización de la SAS unipersonal la cual detenta las características principales de la empresa unipersonal pero la supera al tener todas las ventajas implícitas de la sociedad por acciones simplificada.

  5. La SAS unipersonal y la empresa unipersonal de responsabilidad limitada-similitudes, diferencias, ventajas y proyección de ambas figuras dentro del ordenamiento mercantil colombiano

    Directory of Open Access Journals (Sweden)

    Adriana López

    2012-06-01

    Full Text Available La investigación consta de dos partes. La primera describe el marco regulatorio general de la Empresa Unipersonal y de la Sociedad por Acciones Simplificada (SAS Unipersonal dentro del ordenamiento jurídico colombiano, haciendo énfasis en las similitudes, diferencias y ventajas de una figura sobre la otra, y la segunda parte hace una proyección de ambas figuras dentro del ordenamiento colombiano con base en las características, similitudes, diferencias y ventajas de la una sobre la otra, para llegar a la conclusión de que la utilización de la empresa unipersonal disminuirá progresivamente hasta desaparecer de la práctica jurídica colombiana, para ser remplazada por la utilización de la SAS unipersonal la cual detenta las características principales de la empresa unipersonal pero la supera al tener todas las ventajas implícitas de la sociedad por acciones simplificada.

  6. sas profesionālās lomas pacientu baiļu mazināšanā

    OpenAIRE

    Ivanova, Laura

    2016-01-01

    Bakalaura darba tēma: “Māsas profesionālās lomas pacientu baiļu mazināšanā”. Tēmas aktualitāti nosaka fakts, ka mūsdienās sabiedrība ļoti bieži izjūt bailes un stresu, tāpēc ir svarīgi noskaidrot māsu lomas gan māsu, gan pacientu skatījumā, lai turpmāk māsu sniegtā aprūpe tiktu orientēta uz katra konkrēta pacienta vajadzībām un baiļu mazināšanu. Darba mērķis ir noskaidrot māsas profesionālās lomas pacientu baiļu mazināšanā māsu un pacientu skatījumā. Pētniecības uzdevumi ir: 1.Analizēt lit...

  7. 基于SAS的Web使用日志用户聚类分析%User Cluster Analysis of Web Usages Logs Based on SAS

    Institute of Scientific and Technical Information of China (English)

    欧阳烽

    2013-01-01

    The user cluster Analysis of Web Usages Logs based on SAS is the data of Web Usages Logs for data conversion, get-ting the user transaction table which is pre-formed after the handling of the corresponding data, then making the user cluster anal-ysis through the SAS data mining tools. Digital resources are reasonably procured and managed according to the demands of dif-ferent users on digital resources. Personalized services can be provided for different users.%基于SAS的Web使用日志用户聚类分析,即通过SAS数据挖掘工具将由Web使用日志数据经过数据转换和数据预处理后形成的用户事务表数据运用不同的方法进行聚类分析,以达到根据不同类别用户的需求对数字资源进行合理的采购和管理,为用户提供个性化服务的目的。

  8. Re-examining the role of Drosophila Sas-4 in centrosome assembly using two-colour-3D-SIM FRAP.

    Science.gov (United States)

    Conduit, Paul T; Wainman, Alan; Novak, Zsofia A; Weil, Timothy T; Raff, Jordan W

    2015-11-04

    Centrosomes have many important functions and comprise a 'mother' and 'daughter' centriole surrounded by pericentriolar material (PCM). The mother centriole recruits and organises the PCM and templates the formation of the daughter centriole. It has been reported that several important Drosophila PCM-organising proteins are recruited to centrioles from the cytosol as part of large cytoplasmic 'S-CAP' complexes that contain the centriole protein Sas-4. In a previous paper (Conduit et al., 2014b) we showed that one of these proteins, Cnn, and another key PCM-organising protein, Spd-2, are recruited around the mother centriole before spreading outwards to form a scaffold that supports mitotic PCM assembly; the recruitment of Cnn and Spd-2 is dependent on another S-CAP protein, Asl. We show here, however, that Cnn, Spd-2 and Asl are not recruited to the mother centriole as part of a complex with Sas-4. Thus, PCM recruitment in fly embryos does not appear to require cytosolic S-CAP complexes.

  9. Cerebral scintigraphy by {sup 99m}Tc-HMPAO in sleep apnea syndromes (SAS) during the wakeful state; Scintigraphie cerebrale au Tc99m-HMPAO dans les syndromes d`apnees du sommeil (SAS) pendant l`etat de veille

    Energy Technology Data Exchange (ETDEWEB)

    Tainturier, C.; Benamor, M.; Hausser-Hauw, C.; Rakotonanahary, D.; Fleury, B. [CMC FOCH 92150 SURESNES (France)

    1997-12-31

    The SAS is associated to cerebral hemodynamic modifications and to a high frequency of cerebro-vascular accidents. The aim of this study was to verify, during wakeful state, the cerebral hemodynamic in 14 patients afflicted with SAS of various intensity (Apnea Index = 5-120/h). 555 MBq of {sup 99m}Tc-HMPAO were injected in patients maintained awake. The images were obtained 20 minutes after injection by mean of a double-head chamber equipped with fan-beam collimators. They were interpreted visually by two independent readers. Anomalies of cerebral fixation were observed in 12/14 patients. They were small sores of diffuse hypo-fixations, with a `riddly` aspect (4 cases), sores of bi-temporal hypo-fixation with a right- or left- hemispheric predominance (6 cases), or right fronto-temporal hypo-fixations (2 cases). The cerebral fixation anomalies were reported in the SASs. Ficker et al (1997) have shown in-sleep frontal hypo-perfusions in 5/14 apneic patients, reversible under continuous positive airing pressure (CPAP). In conclusion, anomalies of cerebral fixation exist in SAS-carrying patients, even in the wakeful state. Questions about hypoperfusion, pre-lacunar syndrome, atrophy still remain. A check of this study is planned after the CPAP treatment to determine the hemodynamic or anatomic origin and the anomaly reversibility

  10. A Comprehensive Model of the Dry Desulphurisation Process Une modélisation non empirique du procédé de désulfuration par voie sèche

    Directory of Open Access Journals (Sweden)

    Flament P.

    2006-11-01

    Full Text Available Due to the high investment cost of the wet scrubbing, the dry desulphurisation process remains an attractive way to remove sulphur dioxide when reduction level should not be higher than 90%. In this technique, the SO2 is removed from flue gases by direct injection of small calcium based sorbents such as calcium carbonate (CaCO3 or calcium hydroxide (Ca(OH² . The sorbent is first transformed into calcium oxide (CaO before reacting with SO2 to form a stable calcium sulphate (CaSO4. Although the global reactions are rather simple, a full description of the mechanism requires the knowledge of both, the initial physical properties of the sorbent and the evolution of these properties during the reaction. Furthermore, the way how particles are injected and dispersed into the SO2 containing gases is also a major issue of the dry desulphurisation process. Both aspects are considered in this paper since a specialised routine was build to describe the calcination-sulphation process and coupled with the KIVA code to perform 3D calculations under real industrial conditions. The desulphurisation model was first tested alone using the kinetic data of the International Flame Research Foundation and then, coupled with KIVA to simulate the desulphurisation process in a new type of boiler which is developed by BABCOCK Entreprise and the Institut Français du Pétrole (the AUDE boiler. In this last case, the objective was to determine the sorbent injection locations leading to the highest desulphurisation efficiencies. As the dispersion of particles is an important parameter of the desulphurisation process, an example of validation of the KIVA dispersion model is also presented in this paper. For the selected test case, i. e: particle dispersion in a plane mixing layer, a good agreement was found between the experimental results of Ando et al (1990 and the calculations performed with KIVA. Par suite du coût d'investissement très élevé du procédé de lavage

  11. Efficacy of Phase 3 Trial of RTS, S/AS01 Malaria Vaccine in infants: a systematic review and meta-analysis.

    Science.gov (United States)

    Mahmoudi, Shima; Keshavarz, Hossein

    2017-01-06

    Although vaccines would be the ideal tool for control, prevention, elimination, and eradication of many infectious diseases, developing of parasites vaccines such as malaria vaccine is very complex. The most advanced malaria vaccine candidate is RTS,S, a pre-erythrocytic vaccine for which pivotal phase III trial design is underway. Few recent malaria vaccine review articles have attempted to outline of all clinical trials that have occurred globally and no meta-analysis was performed on efficacy of Phase 3 Trial of RTS, S/AS01 Malaria vaccine up to now in infants. Therefore, a systematic review and meta-analysis was carried out to review new and existing data on efficacy of Phase 3 Trial of RTS, S/AS01 Malaria Vaccine in infants. The electronic databases searched were Pubmed (1965-present) and Web of Science (1970-present) (Search date: May, 2016). After full-text review of the papers evaluating clinical/severe malaria in several well-designed phase III field efficacy trials, 5 were determined to meet the eligibility criteria for inclusion in the systematic review. Four out of the 5 publications dealing with efficacy of Phase 3 Trial of RTS, S/AS01 malaria vaccine were included in the qualitative analysis. Pooled estimate of vaccine efficacy in clinical and severe malaria in children aged 5-17 mo was 29% (95% CL: 19%-46%) and 39% (95% CI 20%-74%), while this estimate vaccine in clinical and severe malaria in children aged 6-12 mo was 19% (95% CI 14%-24%) and 21 (95% CI 19%-37%), respectively. On the other hand, higher VE was seen in both per- protocol and intention-to-treat population in children aged 5-17 than the children aged 6-12 mo. The results of this meta-analysis suggest that this candidate malaria vaccine has relatively little efficacy, and the vaccine apparently will not meet the goal of malaria eradication by itself.

  12. 变电站通信标准向IEC 61850的过渡%Transfering of SAS Communication to IEC 61850 Standard

    Institute of Scientific and Technical Information of China (English)

    肖丽萍; 房同忠

    2006-01-01

    IEC 61850是"变电站通信网络和系统"的系列国际标准,代表了变电站自动化系统(SAS)的最新发展方向.目前广泛应用的变电站通信协议主要是IEC 60870-5-103,因此如何从该协议逐步过渡到IEC 61850是一个现实的课题.本文简要分析了IEC 61850和原有协议之间的异同,并以IEC 60870-5-103规约向IEC 61850标准过渡的一个实例,提出了一种过渡期的解决方法.

  13. SAS-2 gamma-ray results from the galactic plane and their implications for galactic structure and galactic cosmic-ray dynamics

    Science.gov (United States)

    Fichtel, C. E.; Kniffen, D. A.; Thompson, D. J.

    1977-01-01

    The final SAS-2 results related to high energy galactic gamma-ray emission show a strong correlation with galactic structural features seen at other wavelenghts, when the known gamma-ray sources are subtracted. Theoretical considerations and analysis of the gamma-ray data suggest that the galactic cosmic rays are dynamically coupled to the interstellar matter through the magnetic fields, and hence the cosmic ray density is enhanced where the matter density is greatest on the scale of the galactic arms. This concept has been explored in a galactic model that assumes: (1) cosmic rays are galactic and not universal; (2)on the scale of the galactic arms, the cosmic ray column (surface) density is proportional to the total interstellar gas column density; (3)the cosmic ray scale height is significantly larger than the scale height to the matter; and (4) ours is a spiral galaxy characterized by an arm to interarm density ratio of over 2:1.

  14. SAS在辐射剂量-效应研究中的应用%Application of SAS in the study on radiation dose-effect

    Institute of Scientific and Technical Information of China (English)

    刘长安

    2001-01-01

    简述辐射剂量-效应研究中常用的13种数学模型。应用SAS 6.12 for windows统计软件包编写的程序可以方便、快捷地实现辐射剂量-效应曲线的拟合并筛选出最佳的数学模型。%Thirteen mathematical models usually used in study on radiation dose-effect are described in this paper.Radiation dose-effect curve can be fitted conveniently and quickly and an optimal mathematical model for it can be selected with computer programs programmed with Statistical Analysis System(SAS)software package,version 6.12 for windows.

  15. Fibrinogen species as resolved by HPLC-SAXS data processing within the UltraScan Solution Modeler (US-SOMO) enhanced SAS module.

    Science.gov (United States)

    Brookes, Emre; Pérez, Javier; Cardinali, Barbara; Profumo, Aldo; Vachette, Patrice; Rocco, Mattia

    2013-12-01

    Fibrinogen is a large heterogeneous aggregation/degradation-prone protein playing a central role in blood coagulation and associated pathologies, whose structure is not completely resolved. When a high-molecular-weight fraction was analyzed by size-exclusion high-performance liquid chromatography/small-angle X-ray scattering (HPLC-SAXS), several composite peaks were apparent and because of the stickiness of fibrinogen the analysis was complicated by severe capillary fouling. Novel SAS analysis tools developed as a part of the UltraScan Solution Modeler (US-SOMO; http://somo.uthscsa.edu/), an open-source suite of utilities with advanced graphical user interfaces whose initial goal was the hydrodynamic modeling of biomacromolecules, were implemented and applied to this problem. They include the correction of baseline drift due to the accumulation of material on the SAXS capillary walls, and the Gaussian decomposition of non-baseline-resolved HPLC-SAXS elution peaks. It was thus possible to resolve at least two species co-eluting under the fibrinogen main monomer peak, probably resulting from in-column degradation, and two others under an oligomers peak. The overall and cross-sectional radii of gyration, molecular mass and mass/length ratio of all species were determined using the manual or semi-automated procedures available within the US-SOMO SAS module. Differences between monomeric species and linear and sideways oligomers were thus identified and rationalized. This new US-SOMO version additionally contains several computational and graphical tools, implementing functionalities such as the mapping of residues contributing to particular regions of P(r), and an advanced module for the comparison of primary I(q) versus q data with model curves computed from atomic level structures or bead models. It should be of great help in multi-resolution studies involving hydrodynamics, solution scattering and crystallographic/NMR data.

  16. Process optimization studies of 10-Hydroxycamptothecin (HCPT)-loaded folate-conjugated chitosan nanoparticles by SAS-ionic crosslink combination using response surface methodology (RSM)

    Science.gov (United States)

    Zhao, Xiuhua; Jiang, Ru; Zu, Yuangang; Wang, Ying; Zhao, Qi; Zu, Baishi; Zhao, Dongmei; Wang, Meixiang; Sun, Zhiqiang

    2012-01-01

    10-Hydroxycamptothecin (HCPT) is a well-established topoisomerase I inhibitor of a broad spectrum of cancers. However, poor aqueous solubility, low instability, and toxicity to normal tissues have limited its clinical development. A novel HCPT-containing drug carrier system was developed to overcome these disadvantages. The response surface methodology was used to optimize the process of preparing HCPT-chitosan nanoparticles (HCPT-CSNPs) by the SAS-ionic crosslink (supercritical antisolvent SAS) combination method; the resulting HCPT-CSNPs were then conjugated with folate for specific targeting. A central composite design, composed of four independent variables, namely, chitosan concentration, TPP concentration, HCPT nanoparticle concentration, and crosslink time, was applied in the modeling process. The mean particle size and drug entrapment efficiency (DEE) of HCPT-CSNPs were chosen as response variables. The interactive effects of the four independent variables on the response variables were also studied. Nanoparticle characteristics such as morphology, DEE, and mean particle size were investigated. The optimum conditions for preparing HCPT-CSNPs were determined as follows: folate-coupled chitosan concentration 2.46 mg/ml, TPP concentration 7.73 mg/ml, HCPT nanoparticle concentration 0.48 mg/ml, and crosslinking time 47.4 min. Optimum conditions for preparing desired HCPT-CSNPs with a mean particle size of 173.5 nm and entrapment efficiency of 77.3% were obtained. The resulting folate-conjugated HCPT-CSNPs (FA-HCPT-CSNPs) reveal that the amount of folate conjugation was 197.64 mg/g CS. FA-HCPT-CSNPs used in drug carrier systems could have potential value in HCPT-sensitive tumors.

  17. Démonstration du procédé IFP de désulfuration des fumées de centrales Demonstration of the Ifp Stack-Gas Desulfurization Process

    Directory of Open Access Journals (Sweden)

    Busson C.

    2006-11-01

    Full Text Available Les produits pétroliers et le charbon continueront à couvrir les besoins énergétiques pendant plusieurs décennies. La pollution par le SOZ, provenant de la combustion de ces combustibles fossiles, devient une préoccupation pour la population et les Pouvoirs publics. La désulfuration des fumées de combustion devrait, à plus ou moins longue échéance, se développer. L'Institut Français du Pétrole (IFP, mettant à profit ses travaux dans le domaine de la désulfuration, a développé un procédé de traitement des fumées. L'IFP, en collaboration avec Électricité de France (EDF, a effectué en 1976 une opération de démonstration à une échelle pilote (30 MW dans la Centrale de Champagne-sur-Oise. Le procédé consiste à éliminer le S02 des fumées par lavage avec une solution ammoniacale, à produire du soufre à partir de la liqueur obtenue et à recycler l'ammoniaque dans l'étape de lavage. Après quelques modifications d'ordre technologique, l'unité de démonstration a fonctionné d'une manière continue pendant une période de trois mois, correspondant à l'objectif fixé. Les résultats obtenus permettent, actuellement, d'envisager une application de cette technique à une échelle de 250 MW. Oil and coal productswill continue to fulfill energy needs for several more decades. Pollution by SO2 coming from the combustion of such fossil fuels is becoming a preoccupation for the population and the public authorities. The desulfurization of combustion fumes should continue ta develop in the more or less long run. Institut Français du Pétrole (IFP has taken advantage of its research in the fixed of desulfurization to develop a stock-gas treating process. In collaboration with Électricite de Fronce (EDF, IFP carried out a demonsiration operation in 1976 on a pilot-plant scale (30MW in a power plant at Champagne-sur-Oise. The process consists in removing S02 from stock gases by scrubbing them with an ammonia solution

  18. Propriétés électriques et optiques de couches minces de ZnO et ZnO dopé à l'indium, obtenues par le procédé Pyrosol

    Science.gov (United States)

    Tiburcio-Silver, A.; Joubert, J. C.; Labeau, M.

    1992-07-01

    Undoped and indium-doped ZnO thin films deposited by the Pyrosol process onto soda-lime glass substrates were electrically and optically characterized. Resistivities as low as 2× 10^{-3} Ω.cm. Hall mobilities as high as 21 cm^2 V^{-1} s^{-1} and effective carrier concentrations as high as 1 × 10^{20} cm^{-3} have been obtained. Electron concentrations are always lower than indium contents on the films. Average optical transmissions on the whole visible range as high as 85% for the best conductive films have been obtained. Refractive index of layers is modified by the growth temperature and indium doping, been less dependent on doping for high deposition temperatures (better crystallinity). Haacke's figure of merit up to 5× 10^{-3} Ω^{-1} in a 500 nm thick films were obtained. Indium doping improves the time-dependent stability of the electrical properties of ZnO conducting films. Des couches minces de ZnO conducteur non dopé et dopé à l'indium, élaborées par le procédé Pyrosol sur des substrats en verre sodocalcique, ont été caractérisées du point de vue électrique et optique. Résistivités de 2× 10^{-3} Ω.cm, mobilités Hall de 21 cm^2 V^{-1} s^{-1}, et concentrations effectives des porteurs de l'ordre de 1 × 10^{20} cm^{-3} ont été obtenues. La concentration des porteurs mesurée par effet Hall est toujours inférieure à la concentration d'indium dans la couche. La transmission optique moyenne dans le visible atteint 85 % pour les films possédant la meilleure conductivité. La température de dépôt et le dopage à l'indium modifient l'indice de réfraction ; celui-ci dépend moins du dopage à des températures de dépôt élevées (meilleure cristallinité). Les meilleurs facteurs de mérite, \\varnothing_TC, sont de l'ordre de 5× 10^{-3} Ω^{-1} (épaisseur du film 5 000 Å environ). Le dopage à l'indium améliore la stabilité dans le temps des propriétés électriques des couches de ZnO.

  19. La « Nouvelle Mosquée » d’Alger. Le déroulement d’une procédure constructive au xviie siècle

    Directory of Open Access Journals (Sweden)

    Samia Chergui

    2012-01-01

    Full Text Available « La Nouvelle Mosquée » est érigée, à la fin du xviie siècle, dans la seule perspective de doter le rite hanéfite de sa propre Grande Mosquée. Cette nouvelle édification relève, à l’évidence, d’une procédure collective exceptionnelle, celle qu’entreprend la milice d’Alger, en l’occurrence le corps des janissaires, en puisant dans les fonds des Subul al-Khayrât. L’examen du livre de comptes qu’avait tenu cette institution ḥabûs, responsable de la gestion de la plupart des mosquées hanéfites et de leurs awqâf, aussitôt après le lancement du chantier, a permis de suivre le déroulement des travaux sur une période de presque dix années, soit de 1067/1656-1657 à 1076/1665-1666. Ce rôle de chantier apporte des éclairages significatifs notamment sur la nature, la provenance, la quantité et le coût des matériaux employés à la construction. Ils ne manquent pas non plus de documenter les aspects concernant leur fabrication, voire leur préparation, et quelque rares fois leur mise en œuvre ; une mise en œuvre qui, ici, revient à la dextérité de nombreux hommes, mobilisés dans le cadre corporatif. La comptabilité salariale, tenue en cette occasion, compte d’ailleurs parmi les rares initiatives de gestion qui ont permis, durant au moins une décennie, de consigner les plus amples détails non seulement sur le profil distinctif de l’ensemble de ces intervenants, mais également sur leur origine géographique, voire confessionnelle.

  20. Modélisation du procédé de soudage hybride Arc / Laser par une approche level set application aux toles d'aciers de fortes épaisseurs A level-set approach for the modelling of hybrid arc/laser welding process application for high thickness steel sheets joining

    Directory of Open Access Journals (Sweden)

    Desmaison Olivier

    2013-11-01

    Full Text Available Le procédé de soudage hybride Arc/Laser est une solution aux assemblages difficiles de tôles de fortes épaisseurs. Ce procédé innovant associe deux sources de chaleur : un arc électrique produit par une torche MIG et une source laser placée en amont. Ce couplage améliore le rendement du procédé, la qualité du cordon et les déformations finales. La modélisation de ce procédé par une approche Level Set permet une prédiction du développement du cordon et du champ de température associé. La simulation du soudage multi-passes d'une nuance d'acier 18MnNiMo5 est présentée ici et les résultats sont comparés aux observations expérimentales. The hybrid arc/laser welding process has been developed in order to overcome the difficulties encountered for joining high thickness steel sheets. This innovative process gathers two heat sources: an arc source developed by a MIG torch and a pre-located laser source. This coupling improves the efficiency of the process, the weld bead quality and the final deformations. The Level-Set approach for the modelling of this process enables the prediction of the weld bead development and the temperature field evolution. The simulation of the multi-passes welding of a 18MnNiMo5 steel grade is detailed and the results are compared to the experimental observations.

  1. Effect of cell cycle phase on the sensitivity of SAS cells to sonodynamic therapy using low-intensity ultrasound combined with 5-aminolevulinic acid in vitro.

    Science.gov (United States)

    Li, Nan; Sun, Miao; Wang, Yao; Lv, Yanhong; Hu, Zheng; Cao, Wenwu; Zheng, Jinhua; Jiao, Xiaohui

    2015-08-01

    Sonodynamic therapy (SDT) with 5-aminolevulinic acid (5-ALA) can effectively inhibit various types of tumor in vitro and in vivo. However, the association between the efficacy of SDT and the phase of the cell cycle remains to be elucidated. 5-ALA may generate different quantities of sonosensitizer, protoporphyrin IX (PpIX), in different phases of the cell cycle, which may result in differences in sensitivity to 5-ALA-induced SDT. The present study aimed to investigate the effect of the cell cycle on the susceptibility of SAS cells to SDT following synchronization to different cell cycle phases. These results indicates that the rates of cell death and apoptosis of the SAS cells in the S and G2/M phases were significantly higher following SDT, compared with those in the G1-phase cells and unsynchronized cells, with a corresponding increase in PpIX in the S and G2/M cells. In addition, the expression of caspase-3 increased, while that of B-cell lymphoma (Bcl)-2 decreased markedly in theS and G2/M cells following SDT. Cyclin A was also expressed at higher levels in the S and G2/M cells, compared with the G1-phase cells. SDT also caused a significant upregulation of cyclin A in all phases of the cell cycle, however this was most marked in the S and G2/M cells. It was hypothesized that high expression levels of cyclin A in the S and G2/M cells may promote the induction of caspase-3 and reduce the induction of Bcl-2 by SDT and, therefore, enhance apoptosis. Taken together, these data demonstrated that cells in The S and G2/M phases generate more intracellular PpIX, have higher levels of cyclin A and are, therefore, more sensitive to SDT-induced cytotoxicity. These findings indicate the potential novel approach to preventing the onset of cancer by combining cell-cycle regulators with SDT. This sequential combination therapy may be a simple and cost-effective way of enhancing the effects of SDT in clinical settings.

  2. Hotell Radisson SAS = Radisson SAS Hotel / Inga Raukas

    Index Scriptorium Estoniae

    Raukas, Inga, 1967-

    2001-01-01

    Projekteerija Arhitektuuribüroo Künnapu & Padrik. Arhitektid Vilen Künnapu, Ain Padrik, Eero Palm, Tarmo Maiste. Sisekujundajad Christian Lundwall, Jan Öberg. Konstruktsioonid: Teuvo Meriläinen, Jyrki Rautamäki. Projekt ja hotell valmis 2000. 12 ill.: korruste plaanid, sise- ja välisvaated

  3. Hotell Radisson SAS = Radisson SAS Hotel / Inga Raukas

    Index Scriptorium Estoniae

    Raukas, Inga, 1967-

    2001-01-01

    Projekteerija Arhitektuuribüroo Künnapu & Padrik. Arhitektid Vilen Künnapu, Ain Padrik, Eero Palm, Tarmo Maiste. Sisekujundajad Christian Lundwall, Jan Öberg. Konstruktsioonid: Teuvo Meriläinen, Jyrki Rautamäki. Projekt ja hotell valmis 2000. 12 ill.: korruste plaanid, sise- ja välisvaated

  4. Modeling Chemical EOR Processes: Some Illustrations from Lab to Reservoir Scale Modélisation des procédés EOR chimiques : du laboratoire au réservoir

    Directory of Open Access Journals (Sweden)

    Douarche F.

    2013-02-01

    Full Text Available Chemical flooding, SP (Surfactant Polymer or ASP (Alkali-Surfactant-Polymer, are of increasing interest due to the need to increase oil production. Design of chemical processes is very project specific and requires case by case studies including various steps among which reservoir data analysis, chemical formulations, coreflood validations and reservoir simulation. Every step is dependent on the preceding ones and the last reservoir simulation step gathers all the information collected during the project. In this paper, we present a chemical simulator describing two phase flow with chemical transport of alkali, surfactant, polymer and salinity. Two phase flow is related to capillary desaturation curve through the decrease of oil-water interfacial tension. Physical chemistry reactions are described either with a thermodynamic approach or a simplified one using tables or simplified physics to be compatible with large scale reservoir simulations. In this paper, we describe the simulator and present results of numerous experiments specially designed to validate the model: alkaline injections of carbonates and borates, surfactant adsorption experiments at different salinities and pH, systematic effect of salinity on interfacial tension and oil recovery with/without salinity gradient. The good agreement between the experimental and numerical oil recoveries and chemical compositions is very encouraging and supports the validity of the physics implemented in the simulator. In particular, the dominant effect of pH on adsorption and the importance of a salinity gradient on oil recovery is highlighted by numerical simulation. Finally, a sensitivity study at the reservoir scale is presented to illustrate relevant factors for the implementation of an economic surfactant-based process. Les procédés de récupération tertiaire par voie chimique, SP (Surfactant Polymer ou ASP (Alkali-Surfactant-Polymer, sont en plein essor du fait d’une demande croissante

  5. Study on SAS image segmentation using SVM based on statistical and texture features%基于统计和纹理特征的SAS图像SVM分割研究

    Institute of Scientific and Technical Information of China (English)

    陈强; 田杰; 黄海宁; 张春华

    2013-01-01

    Synthetic aperture sonar (SAS) images can effectively describe the topography,geomorphology and substrate of seabed;however,one single SAS image usually corresponds to a larger area ;so it is necessary to segment the SAS image into different regions according to certain property,which benefits further analyzing the image,and detecting and identifying the target.Study found that SAS images of different substrates have different statistical and texture features;in this paper,the statistical properties,such as the mean,standard deviation and kurtosis of the grey level histogram,as well as the texture features,such as the energy,correlation,contrast and entropy of the grey level co-occurrence matrix are selected and used to describe different regions of the SAS image.These selected features are used as the support vector machine (SVM) training characteristics and the classifier is obtained for the SAS image segmentation.The experiment results show that the proposed SVM algorithm is a good segmentation method for the region segmentation of SAS image.%合成孔径声呐图像可以有效反映海底的地形、地貌和底质等情况,但是单幅SAS图像通常对应一片较大的区域,需要按照某种性质将不同性质的区域分割开来,以有利于下一步的图像分析以及目标检测和识别.研究发现,不同底质区域的SAS图像具有不同的统计和纹理特征,选取灰度直方图的均值、标准差、峰度等统计特性和灰度共生矩阵的能量、相关性、对比度、熵值等纹理特性用以描述SAS图像的不同区域.将选取的特征作为SVM的训练特征,进而得到SVM分类器,用于SAS图像分割.实验结果表明,SVM算法可以很好地对SAS图像进行区域分割.

  6. 采用Vernier阵技术的SAS图像重建%Image Reconstruction for Synthetic Aperture Sonar (SAS) System with Vernier Array Technique

    Institute of Scientific and Technical Information of China (English)

    蒋小奎; 孙超; 冯杰

    2005-01-01

    在采用Vernier阵技术时,为了避免由于等效相位中心(DPC)近似而引起的合成孔径声纳(SAS)图像模糊,提出一种新的数据处理方法,该方法根据收发分置成像的几何特性,采用修正的距离-多普勒算法对单个接收元信号独立进行合成孔径处理,并将独立处理产生的所有图像相干叠加,得到SAS系统的高分辨图像.对DPC近似处理、单个接收元合成孔径处理以及相干叠加处理的计算机仿真结果进行了比较,结果验证了该处理方法的可行性和有效性,并且进一步验证了Vernier阵技术的高分辨特性.

  7. SAS-2 observations of the diffuse gamma radiation in the galactic latitude interval from 10 to 90 deg in both hemispheres

    Science.gov (United States)

    Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.; Thompson, D. J.; Ogelman, H. B.; Ozel, M. E.; Tumer, T.

    1977-01-01

    An analysis of all the second Small Astronomy Satellite (SAS-2) gamma-ray data for galactic latitudes higher than 10 deg in both hemispheres has shown that the intensity varies with galactic latitude, being larger near 10 deg than 90 deg. For energies above 100 MeV the gamma-ray data are consistent with a latitude distribution of the form I(b) = C1 + C2/sin b, with the second term being dominant. This result suggests that the radiation above 100 MeV is coming largely from local regions of the galactic disk. Between 35 and 100 MeV, a similar equation is also a good representation of the data, but here the two terms are comparable. These results indicate that the diffuse radiation above 35 MeV consists of two parts, one with a relatively hard galactic component and the other an isotropic steep spectral component which extrapolates back well to the low-energy (less than 10 MeV) diffuse radiation. The steepness of the diffuse isotropic component places significant constraints on possible theoretical models of this radiation.

  8. Gypenosides inhibits migration and invasion of human oral cancer SAS cells through the inhibition of matrix metalloproteinase-2 -9 and urokinase-plasminogen by ERK1/2 and NF-kappa B signaling pathways.

    Science.gov (United States)

    Lu, Kung-Wen; Chen, Jung-Chou; Lai, Tung-Yuan; Yang, Jai-Sing; Weng, Shu-Wen; Ma, Yi-Shih; Lu, Pei-Jung; Weng, Jing-Ru; Chueh, Fu-Shin; Wood, W Gibson; Chung, Jing-Gung

    2011-05-01

    Gypenosides (Gyp), found in Gynostemma pentaphyllum Makino, has been used as a folk medicine in the Chinese population for centuries and is known to have diverse pharmacologic effects, including anti-proliferative and anti-cancer actions. However, the effects of Gyp on prevention from invasion and migration of oral cancer cells are still unsatisfactory. The purpose of this study was to investigate effects of Gyp treatment on migration and invasion of SAS human oral cancer cells. SAS cells were cultured in the presence of 90 and 180 μg/mL Gyp for 24 and 48 hours. Gyp induced cytotoxic effects and inhibited SAS cells migration and invasion in dose- and time-dependent response. Wound-healing assay and boyden chamber assay were carried out to investigate Gyp-inhibited migration and invasion of SAS cells. Gyp decreased the abundance of several proteins, including nuclear factor-kappa B (NF-κB), cyclooxygenase-2 (COX-2), extracellular signal-regulated kinase 1/2 (ERK1/ 2), matrix metalloproteinase-9, -2 (MMP-9, -2), sevenless homolog (SOS), Ras, urokinase-type plasminogen activator (uPA), focal adhesion kinase (FAK) and RAC-alpha serine/threonine-protein kinase (Akt), in a time-dependent manner. In addition, Gyp decreased mRNA levels of MMP-2, MMP-7, MMP-9 but did not affect FAK and Rho A mRNA levels in SAS cells. These results provide evidences for the role of Gyp as a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of oral cancer cells. The inhibition of NF-κB and MMP-2, -7 and -9 signaling may be one of the mechanisms that is present in Gyp-inhibited cancer cell invasion and migration.

  9. Multilevel models applications using SAS

    CERN Document Server

    Wang, Jichuan; Fisher, James F

    2011-01-01

    This book covers a broad range of topics about multilevel modeling. The goal is to help readers to understand the basic concepts, theoretical frameworks, and application methods of multilevel modeling. It is at a level also accessible to non-mathematicians, focusing on the methods and applications of various multilevel models and using the widely used statistical software SAS®. Examples are drawn from analysis of real-world research data.

  10. Multilevel Models Applications Using SAS

    CERN Document Server

    Wang, Jichuan; Fisher, James

    2011-01-01

    This book covers a broad range of topics about multilevel modeling. The goal is to help readersto understand the basic concepts, theoretical frameworks, and application methods of multilevel modeling. Itis at a level also accessible to non-mathematicians, focusing on the methods and applications of various multilevel models and using the widely used statistical software SAS®.Examples are drawn from analysis of real-world research data.

  11. Laborsalud S.A.S.

    OpenAIRE

    2013-01-01

    Crear una empresa prestadora de servicios integrales en salud ocupacional basados en la legislación vigente y enfocada a la satisfacción de las necesidades de los clientes, que brinde un valor agregado como expertos con un sistema de resultados en línea a través de su página web y amplio portafolio que integre los requerimientos en materia de salud ocupacional y seguridad industrial de las empresas.

  12. Radisson SAS tutvustab noori kunstnikke

    Index Scriptorium Estoniae

    2006-01-01

    Näitusest hotelli konverentsikeskuses, millega tähistatakse noorte eesti kunstnike loomingut eksponeeriva internetikunstigalerii Globeart loomist. Eksponeeritakse Paul Sontagi, Rauno Thomas Mossi jt. kunstnike töid

  13. Biomass Conversion to Hydrocarbon Fuels Using the MixAlcoTM Process Conversion de la biomasse en combustibles hydrocarbonés au moyen du procédé MixAlcoTM

    Directory of Open Access Journals (Sweden)

    Taco-Vasquez S.

    2013-04-01

    Full Text Available The MixAlcoTM process converts biomass to hydrocarbons (e.g., gasoline using the following generic steps: pretreatment, fermentation, descumming, dewatering, thermal ketonization, distillation, hydrogenation, oligomerization and saturation. This study describes the production of bio-gasoline from chicken manure and shredded office paper, both desirable feedstocks that do not require pretreatment. Using a mixed culture of microorganisms derived from marine soil, the biomass was fermented to produce a dilute aqueous solution of carboxylate salts, which were subsequently descummed and dried. The dry salts were thermally converted to raw ketones, which were distilled to remove impurities. Using Raney nickel catalyst, the distilled ketones were hydrogenated to mixed secondary alcohols ranging from C3 to C12. Using zeolite HZSM-5 catalyst, these alcohols were oligomerized to hydrocarbons in a plug -flow reactor. Finally, these unsaturated hydrocarbons were hydrogenated to produce a mixture of hydrocarbons that can be blended into commercial gasoline. Le procédé MixAlcoTM convertit la biomasse en hydrocarbures (par exemple, en essence selon les étapes génériques suivantes : prétraitement, fermentation, écumage, déshydratation, cétonisation thermique, distillation, hydrogénation, oligomérisation et saturation. Cette étude décrit la production de bioessence à partir de fumier de poulet et de papier en lambeaux, ces deux sources étant des matières premières convoitées ne nécessitant pas de prétraitement. À l’aide d’une culture mixte de microorganismes dérivés de sols marins, la biomasse a été soumise à une fermentation de manière à produire une solution aqueuse diluée de sels de carboxylates, ultérieurement écumés et séchés. Les sels séchés ont été thermiquement convertis en cétones brutes, ensuite distillées afin d’éliminer les impuretés. À l’aide du catalyseur à base de nickel de Raney, les c

  14. Development of standardized laboratory methods and quality processes for a phase III study of the RTS, S/AS01 candidate malaria vaccine

    Directory of Open Access Journals (Sweden)

    Carter Terrell

    2011-08-01

    Full Text Available Abstract Background A pivotal phase III study of the RTS,S/AS01 malaria candidate vaccine is ongoing in several research centres across Africa. The development and establishment of quality systems was a requirement for trial conduct to meet international regulatory standards, as well as providing an important capacity strengthening opportunity for study centres. Methods Standardized laboratory methods and quality assurance processes were implemented at each of the study centres, facilitated by funding partners. Results A robust protocol for determination of parasite density based on actual blood cell counts was set up in accordance with World Health Organization recommendations. Automated equipment including haematology and biochemistry analyzers were put in place with standard methods for bedside testing of glycaemia, base excess and lactacidaemia. Facilities for X-rays and basic microbiology testing were also provided or upgraded alongside health care infrastructure in some centres. External quality assurance assessment of all major laboratory methods was established and method qualification by each laboratory demonstrated. The resulting capacity strengthening has ensured laboratory evaluations are conducted locally to the high standards required in clinical trials. Conclusion Major efforts by study centres, together with support from collaborating parties, have allowed standardized methods and robust quality assurance processes to be put in place for the phase III evaluation of the RTS, S/AS01 malaria candidate vaccine. Extensive training programmes, coupled with continuous commitment from research centre staff, have been the key elements behind the successful implementation of quality processes. It is expected these activities will culminate in healthcare benefits for the subjects and communities participating in these trials. Trial registration Clinicaltrials.gov NCT00866619

  15. Synthesis and Evaluation of Water Soluble MA/SAS Polymer Scale Inhibitor%MA/SAS水溶性聚合物阻垢剂的合成与评价

    Institute of Scientific and Technical Information of China (English)

    王忠辉; 刘庆旺

    2005-01-01

    以马来酸酐(MA)和烯丙基磺酸钠(SAS)为原料,制得MA/SAS水溶性聚合物阻垢剂.确定了最佳工艺条件:n(MA):n(SAS)=1:1,体系pH值4.0~4.5,反应温度75~80℃,反应时间4~5 h.MA/SAS水溶性聚合物阻垢性能优于现在常用的阻垢剂HEDP,并与其他油田常用药剂具有良好的配伍性.在现场试验中,MA/SAS聚合物阻垢剂阻垢率可达90%,效果明显.

  16. Catalyseurs et procédés catalytiques utilisés dans la production des grands intermédiaires pétrochimiques. Situation actuelle et futur Catalysts and Catalytic Processes Used for the Production of the Major Petrochemical Building Blocks. Present Situation and the Future

    Directory of Open Access Journals (Sweden)

    Boitiaux J. P.

    2006-11-01

    Full Text Available La pétrochimie représente une part modeste du marché des catalyseurs, mais les dix dernières années ont vu des améliorations substantielles des catalyseurs et des procédés utilisés. Ces améliorations ont permis de mieux répondre à la demande en grands intermédiaires pétrochimiques. Cette évolution est bien illustrée par les hydrogénations, autour du vapocraquage destiné à produire des oléfines, par le reformage catalytique et les procédés satellites destinés à produire des aromatiques et par les nouveaux procédés de déshydrogénation, métathèse, oligomérisation. . . qui permettent de mieux équilibrer le marché des oléfines. Petrochemicals account for a modest share of the market for catalysts, but there have been substantial improvements in the catalysts and processes used in the last ten years. These improvements have brought about a better response to the demand for major petrochemical building blocks. This trend is clearly illustrated by hydrogenations in the field of steam cracking to produce olefins, by catalytic reforming and satellite processes to produce aromatics, and by new processes such as dehydrogenation, metathesis and oligomerization which provide better balance to the market for olefins.

  17. Sleep-disordered breathing in acute ischemic stroke and transient ischemic attack: effects on short- and long-term outcome and efficacy of treatment with continuous positive airways pressure--rationale and design of the SAS CARE study.

    Science.gov (United States)

    Cereda, Carlo W; Petrini, Liliane; Azzola, Andrea; Ciccone, Alfonso; Fischer, Urs; Gallino, Augusto; Györik, Sandor; Gugger, Matthias; Mattis, Johannes; Lavie, Lena; Limoni, Costanzo; Nobili, Lino; Manconi, Mauro; Ott, Sebastian; Pons, Marco; Bassetti, Claudio L

    2012-10-01

    Sleep-disordered breathing represents a risk factor for cardiovascular morbidity and mortality and negatively affects short-term and long-term outcome after an ischemic stroke or transient ischemic attack. The effect of continuous positive airways pressure in patients with sleep-disordered breathing and acute cerebrovascular event is poorly known. The SAS CARE 1 study assesses the effects of sleep-disordered breathing on clinical evolution, vascular functions, and markers within the first three-months after an acute cerebrovascular event. The SAS CARE 2 assesses the effect of continuous positive airways pressure on clinical evolution, cardiovascular events, and mortality as well as vascular functions and markers at 12 and 24 months after acute cerebrovascular event. SAS CARE 1 is an open, observational multicenter study in patients with acute cerebrovascular event acutely admitted in a stroke unit: a sample of 200 acute cerebrovascular event patients will be included. Vascular functions and markers (blood pressure, heart rate variability, endothelial function by peripheral arterial tonometry and specific humoral factors) will be assessed in the acute phase and at three-months follow-up. SAS CARE 2 will include a sample of patients with acute cerebrovascular event in the previous 60-90 days. After baseline assessments, the patients will be classified according to their apnea hypopnea index in four arms: non-sleep-disordered breathing patients (apnea hypopnea index acute cerebrovascular event and the feasibility/efficacy of continuous positive airways pressure treatment in selected patients with acute cerebrovascular event and sleep-disordered breathing. © 2012 The Authors. International Journal of Stroke © 2012 World Stroke Organization.

  18. The Risk Factors Affecting and the Influence on the QOL of Patients with SAS%老年SAS患者生存质量及其影响因素分析

    Institute of Scientific and Technical Information of China (English)

    鲁丹

    2011-01-01

    Objective:To explore the risk factors affecting the quality of life(QOL)of patients with obstructive sleep apnea (SAS).Methods:Measuring the quality of life of 150 patients suffered from SAS with WHO QOL-BREF and analyzing the influences of the sleepiness, quality of sleep.Results:The scores on physical domain and psychological domain of patients were less than that of normal person.Conclusions: The sleepiness quality of sleep can affect the QOL of patients with SAS.%目的:探讨老年睡眠呼吸暂停综合征(SAS)患者生存质量及其影响因素.方法:采用WHOQOL-BREF生存质量量表对150例SAS患者进行生存质量测评,并进一步比较嗜睡、睡眠质量对患者生存质量的影响.结果:SAS患者质量评分较低,生理领域评分最低.社会因素、医学因素、自我评价对生存质量影响有显著性意义.SAS组生存质量生理领域、心理领域得分低于健康对照,SAS组内嗜睡组低于不嗜睡组、睡眠质量差组低于睡眠质量好组(P均<0.05).结论:SAS患者的嗜睡、低睡眠质量及慢性病是影响生活质量的因素.

  19. Discussion on the paper entitled "Indian Contribution in the Field of Palaeo-oceanography (2006-2012)" by A K Gupta et al., 2012. Proc Indian Nat Sci Acad Vol. 78, No. 3 (IUGS Special Issue) pp. 313-319: Serious flaws in the status report on Indian palaeoceanography

    Digital Repository Service at National Institute of Oceanography (India)

    Banakar, V.K.

    published papers, which are based on sediment cores collected by several Indian researchers on-board the Indian research vessels”. The third paragraph of Banakar’s comments again raises the question of not incorporating some references. Also he has mentioned... Discussion Discussion on the paper entitled “Indian Contribution in the Field of Palaeo-oceanography (2006-2012)” by A K Gupta et al., 2012. Proc Indian Nat Sci Acad Vol. 78, No. 3 (IUGS Special Issue) pp. 313-319 Discussion: Serious Flaws in the Status...

  20. Behavior of an heterogeneous annular FBR core during an unprotected loss of flow accident: Analysis of the primary phase with SAS-SFR

    Energy Technology Data Exchange (ETDEWEB)

    Massara, S.; Schmitt, D.; Bretault, A.; Lemasson, D.; Darmet, G.; Verwaerde, D. [EDF R and D, 1, Avenue du General de Gaulle, 92141 Clamart (France); Struwe, D.; Pfrang, W.; Ponomarev, A. [Karlsruher Institut fuer Technologie KIT, Institut fuer Neutronenphysik und Reaktortechnik INR, Hermann-von-Helmholtz-Platz 1, Gebaude 521, 76344 Eggenstein-Leopoldshafen (Germany)

    2012-07-01

    In the framework of a substantial improvement on FBR core safety connected to the development of a new Gen IV reactor type, heterogeneous core with innovative features are being carefully analyzed in France since 2009. At EDF R and D, the main goal is to understand whether a strong reduction of the Na-void worth - possibly attempting a negative value - allows a significant improvement of the core behavior during an unprotected loss of flow accident. Also, the physical behavior of such a core is of interest, before and beyond the (possible) onset of Na boiling. Hence, a cutting-edge heterogeneous design, featuring an annular shape, a Na-plena with a B{sub 4}C plate and a stepwise modulation of fissile core heights, was developed at EDF by means of the SDDS methodology, with a total Na-void worth of -1 $. The behavior of such a core during the primary phase of a severe accident, initiated by an unprotected loss of flow, is analyzed by means of the SAS-SFR code. This study is carried-out at KIT and EDF, in the framework of a scientific collaboration on innovative FBR severe accident analyses. The results show that the reduction of the Na-void worth is very effective, but is not sufficient alone to avoid Na-boiling and, hence, to prevent the core from entering into the primary phase of a severe accident. Nevertheless, the grace time up to boiling onset is greatly enhanced in comparison to a more traditional homogeneous core design, and only an extremely low fraction of the fuel (<0.1%) enters into melting at the end of this phase. A sensitivity analysis shows that, due to the inherent neutronic characteristics of such a core, the gagging scheme plays a major role on the core behavior: indeed, an improved 4-zones gagging scheme, associated with an enhanced control rod drive line expansion feed-back effect, finally prevents the core from entering into sodium boiling. This major conclusion highlights both the progress already accomplished and the need for more detailed

  1. 应用SAS软件宏命令实现二分类数据的Meta分析%Application of SAS software macros for realizing Meta-analysis of two-category data

    Institute of Scientific and Technical Information of China (English)

    鄢金柱; 李胜; 翁鸿; 曾宪涛

    2014-01-01

    SAS system is considered as one of international standard software systems in the field of data processing and statistics, however, it required the user has higher capability due to its complex and difficult programming. For well applying SAS for conducting a Meta-analysis, Stephen Senna and his colleagues developed a suite of macros for the Meta-analysis of binary data. These macros will realize the Meta-analysis of binary data conveniently and can generate the forest plot, funnel plot, Galbraith plot, Q-Q plot and other graphs. The authors introduced in the paper how to use these SAS macros for conducting the Meta-analysis of binary data.%SAS被誉为国际上数据处理和统计分析领域的标准软件系统,但其程序编写复杂且难度较大,对使用者的要求较高。为了更好的使用SAS软件实现Meta分析,Stephen Senna等人编写了一套专用于二分类资料的Meta分析的宏命令。这套宏语言可以方便的实现Meta分析,绘制森林图、漏斗图、加尔布雷斯图、Q-Q正态分布图等图形。本文结合实例对应用SAS宏语言实现二分类数据Meta分析的方法进行详细介绍。

  2. Calidad de atención percibida y calidad de vida relacionada con la salud en pacientes participantes de estudios clínicos de la ips idearg sas.

    OpenAIRE

    González Gamboa, Carolina Stella

    2015-01-01

    La presente investigación surge en el programa de Bienestar y Calidad de Vida suscrito a la Línea de Liderazgo en la Escuela de Administración de la Universidad del Rosario, con el objetivo de describir si las subdimensiones de la calidad de la atención percibida guardan relación con la calidad de vida relacionada con la salud en los pacientes participantes en Estudios Clínicos en la Institución Prestadora de Servicios de Salud IDEARG SAS, considerando si los factores sociodemográficos se con...

  3. Evaluación de la gestión de residuos derivados del proceso de impresión en Datapoint de Colombia S.A.S, y propuesta de mejora

    OpenAIRE

    Fino Gallego, Sandra Patricia; Gómez Gianine, Carol Ruchina; Ruano Reyes, Sandra Milena

    2015-01-01

    Este trabajo se centra en el análisis de las actividades desarrolladas en torno a los servicios de procesos de impresión que ofrece la organización DATAPOINT de Colombia SAS para identificar los puntos críticos en la gestión de los residuos de impresión y las decisiones tomadas por parte de los involucrados durante todo el proceso (proveedores, clientes y la empresa), con el fin de revisar medidas y estrategias que permitan fortalecer la gestión integral de residuos de impresión a partir d...

  4. Diseño del sistema de gestión integrado de calidad NTC ISO 9001:2008 y medio ambiente NTC ISO 14001:2004 en Aerologistics S.A.S.

    OpenAIRE

    2012-01-01

    Con el fin de encontrar mejores oportunidades para la empresa Aerologistics S.A.S., se busca diseñar el Sistema de Gestión Integrado que proporcione mayor orden y mejor perspectiva por parte del cliente de lo que es el negocio y los servicios de la empresa. Se busca diseñar un Sistema de gestión con base en las normas NTC ISO 9001: 2008 y NTC ISO 14001: 2004 con el fin de mejorar la gestión de la calidad y ambiental de la actividad de la empresa.

  5. Diseño del plan integrado de gestión basado en las normas ISO 14001:2004 y OHSAS 18001:2007 en Ingeniería del Valle de Mares, Vallmar S.A.S

    OpenAIRE

    Vera Rodríguez, Aura Milena

    2013-01-01

    Evalúa la situación actual de los sistemas de riesgos laborales y medio ambiente en la empresa Vallmar S.A.S., por medio de matrices de riesgos e impactos ambientales. Acorde al resultado de dicho análisis se realiza el diseño del plan integral de gestión, tanto para el contexto administrativo como el operativo de la empresa bajo la norma ISO 14001:2004 y OHSAS 18001:2007. Esta investigación permitirá analizar el funcionamiento de la empresa, evaluando los diferentes procesos, y realizand...

  6. Plan de mejoramiento para el área de logística a nivel local de la compañía RotamAgrochemical Colombia S.A.S.

    OpenAIRE

    Gómez Susa, Martha Jannett; Morales Valero, Nadine Stella; Mosquera López, Diana Milena

    2013-01-01

    El trabajo pretende diseñar un plan de mejoramiento en el área logística que agregue valor, aumente la eficiencia y mejore los procesos de almacenamiento y distribución, gestión de inventarios y control de los productos agroquímicos de la Compañía RotamAgrochemical Colombia S.A.S., se formulan algunas recomendaciones para el mejoramiento de los procesos en las Áreas de almacenamiento, inventarios y seguridad industrial

  7. SAS、PASS、Stata三种常用软件样本量计算方法及结果差异的比较%Comparing the differences between SAS, PASS and Stata for sample size calculation

    Institute of Scientific and Technical Information of China (English)

    林洁; 孙志明

    2015-01-01

    Objective To analyze the differences between SAS, PASS and Stata for sample size calculation in a test of two means (rates) and recommend the appropriate software for sample size calculation. Methods By setting different pa-rameters, sample sizes were calculated using three kinds of software respectively and compared with the formula results. Results In two sample means test, Stata and PASS had the most accurate results, the results in SAS were affected by different parameters. In two sample rates test, the SAS results were the best of three, the accuracy of PASS was related with the sample size, the results in Stata were larger than others and affected by different parameters. Conclusion The results are not consistent using different software, SAS is recommended for two sample mean (rate) of sample size calcu-lation.%目的:分析和探讨运用SAS、PASS、Stata 3种软件在两均数(率)比较中进行样本量估计的结果差异,推荐合适的样本量估计软件。方法通过设定不同的参数情况,分别运用3种软件计算各自样本量,并且与公式计算结果进行比较。结果在两均数比较时,Stata和PASS的样本量估计结果最准确,不同的参数会影响SAS的结果;在两个率比较时,SAS最准确,PASS的准确性与样本量大小有关系,Stata结果偏大且受不同参数的影响。结论不同软件计算结果并不一致,综合考虑推荐用SAS软件进行两样本均数(率)比较的样本量估计。

  8. Etudes de traitement des lixiviats des déchets urbains par les procédés d’oxydation avancée photochimiques et électrochimiques : application aux lixiviats de la décharge tunisienne "Jebel Chakir"

    OpenAIRE

    2011-01-01

    Pas de résumé en anglais; L'installation de décharges sanitaires représente la seule méthode de stockage des déchets ménagers solides dans plusieurs pays. Les lixiviats générés à partir de ces décharges présentent une grande toxicité aigüe et chronique. Lorsqu'ils ne sont pas traités, ces lixiviats peuvent pénétrer dans la nappe phréatique ou contaminer les eaux de surface et donc contribuer à la pollution des eaux. Divers procédés biologiques ont été appliqués au traitement des lixiviats de ...

  9. Sondes intégrées résonantes de lumière : Micro-résonateurs sur polymères couplés aux technologies et procédés issus de la chimie, des plasmas, de la micro-fluidique et de la biophysique

    OpenAIRE

    Bêche, Bruno; Huby, Nolwenn; Moréac, Alain; Vié, Véronique; Panizza, Pascal; Lhermite, Hervé; Solal, Francine

    2015-01-01

    National audience; Au cours de cette allocution, quelques voies de recherche et développement en photonique intégrée à base de matériaux organiques seront développées. Plusieurs approches hybrides qui sont issues de domaines transverses de la physique et de la chimie pour la réalisation de Micro-Résonateurs (MRs) 2D, 2.5D et 3D sur polymères seront présentées. De telles voies parallèles soulignent l'intérêt de développer des technologies et procédés hybrides, comme les traitements plasmas, la...

  10. Thermal Stability of Gas Oil Hydrotreating Processes: Numerical Issues of the Matrix-Eigenvalue Approach Stabilité thermique de procédés d’hydrotraitement des gazoles : aspects numériques de l’approche par valeurs propres matricielles

    Directory of Open Access Journals (Sweden)

    Schweitzer J.-M.

    2010-10-01

    Full Text Available Processes carrying out exothermic reactions must ensure safe operating conditions to avoid uncontrolled thermal excursion, also known as runaway. Therefore, a thermal stability analysis is necessary to determine the safe and productive range of operating conditions of highly exothermic processes. Hydrotreating gas oil feeds consists mainly of hydrogenation reactions; processing highly unsaturated feeds such as light cycle oils can be highly exothermic. For this reason, a thermal stability study of this complex refining is performed. Perturbations theory has already been applied to carry out a thermal stability study of this process under dynamic conditions. This method consists in the perturbation of the hydrotreating reactor model and solution of the perturbed model in the form of an eigenvalue problem. The stability condition imposes that all perturbations must tend to zero when time tends to infinity. Some methodology and numerical aspects applying this theory and the effect on stability results are tackled in this work. The formalization of the perturbed model solution as a standard eigenvalue problem or as a generalized eigenvalue problem are presented. The computation of the Jacobian by a numerical approach or with the analytical expressions is also carried out. In both cases, results are compared and their influence on the stability/instability results is presented. Les procédés qui mettent en oeuvre des réactions très exothermiques nécessitent une attention particulière afin d’éviter l’augmentation non contrôlée de la température connue comme emballement thermique. Une analyse de stabilité thermique est nécessaire afin d’établir les conditions d’opération sûre et productive des procédés exothermiques. L’hydrotraitement de gazoles met en oeuvre principalement des réactions d’hydrogénation ; l’hydrotraitement de charges très insaturées comme les gazoles light cycle oil peut être fortement exothermique

  11. Hydrocraquage sous pression d'une huile de soja : procédé d'étude et allure générale de la transformation Soybean Oil Hydrocracking under Pressure: Process and General Aspect of the Transformation

    OpenAIRE

    Nunes P. P.; Brodzki D.; Bugli G.; Djega-Mariadassou G.

    2006-01-01

    Un procédé d'étude de l'hydrocraquage des huiles végétales en autoclave est décrit. Les principaux objectifs de cette étude sont relatifs à la transformation de l'huile de soja (composé modèle) en essence et gazole, en limitant la formation de polymères et de coke. L'analyse des gaz et la chromatographie haute résolution de deux fractions résultant de la distillation sous vide de la phase liquide ont permis de mettre en évidence les principales étapes de l'hydrocraquage. Pour cette première a...

  12. Toward a Competitive Process Intensification: A New Generation of Heat Exchanger-Reactors Vers une intensification des procédés économiquement viable : une nouvelle génération de réacteur-échangeur de chaleur

    Directory of Open Access Journals (Sweden)

    Tochon P.

    2010-10-01

    Full Text Available Process Intensification (PI in chemical production is a major concern of chemical manufacturers. Among the numerous options to intensify a process, the transposition from a batch reactor to a continuous plug flow reactor is a good alternative when the selectivity and the thermal exchange are an issue. In this context, the RAPIC R&D project aims to develop an innovative low-cost component (in the 10 kg/h range. This project deals with the design from the local to the global scale and with testing, from elementary mock-ups to pilot scale. The present paper gives a detailed description of this research project and presents the main results on specification and definition of the reaction channel and the first simple mock-ups. L’intensification des procédés (IP constitue une des préoccupations majeures de l’industrie chimique. Parmi les nombreuses options possibles pour intensifier un procédé, lorsque le sujet concerne la sélectivité et l’échange thermique, la transposition d’un réacteur discontinu à un réacteur tubulaire continu paraît une bonne alternative. Dans ce contexte, le projet de R&D RAPIC consiste à développer un composant innovant à bas coût (environ 10 kg/heure. Ce projet porte sur la phase de conception, du niveau local au niveau global, et sur la phase de tests, depuis les maquettes élémentaires jusqu’aux essais pilote. Cet article propose une description détaillée de ce projet de recherche et présente les principaux résultats obtenus sur la définition et la spécification du canal de réaction, ainsi que les premières maquettes simples.

  13. La production des oléfines. Etat de la technique et développement dans le domaine des réacteurs chimiques et des procédés Olefin Production. State of Technology and Developement in the Field of Chemical Reactors and Processes

    Directory of Open Access Journals (Sweden)

    Amouyal R.

    2006-11-01

    Full Text Available La production des oléfines légères : éthylène, propylène et butadiène est actuellement entièrement basée sur le vapocraquage d'hydrocarbures dans des fours tubulaires. L'industrie doit faire face à un problème de coûts de production croissants, en grande partie dû au renchérissement des hydrocarbures et de l'énergie. D'autres procédés que le vapocraquage ont été proposés pour favoriser la diversification sur le plan des matières premières ; certains ont même été exploités industriellement. Le présent article fait le point sur l'état des développements en cours concernant plus particulièrement les procédés suivants : - craquage autothermique ; - craquage par caloporteur solide ; - craquage cyclique ; - craquage catalytique ; - prétraitement de charges lourdes ; - oléfines à partir de gaz de synthèse ; - oléfines à partir de biomasse. The production of light olefins (ethylene, propylene and butadien is now based entirely on hydrocarbon steam cracking in pipe stills. The industry must face the problem of increasing production costs, largely due to the higher costs of hydrocarbons and energy. Processes other than steam cracking have been proposed to promote diversification with regard to raw materials, and some such processes have even operated industrially. This article sums up the state of ongoing developments concerning in particular the following processes: a autothermal cracking; b cracking by a solid heat carrier; c cyclic cracking; d catalytic cracking ; e preprocessing of heavy feeds; f olefins from synthetic gas; g olefins from biomass.

  14. Unexplained factors and their effects on second pass R-squared's and t-tests

    NARCIS (Netherlands)

    Kleibergen, F.; Zhan, Z.

    2013-01-01

    We construct the large sample distributions of the OLS and GLS R2’s of the second pass regression of the Fama-MacBeth (1973) two pass procedure when the observed proxy factors are minorly correlated with the true unobserved factors. The small correlation implies a sizeable unexplained factor structu

  15. Research of Linear Programming Problem on SAS/or and LINGO Mathematics Softwear%应用SAS/OR与LINGO求解优化问题的比较研究

    Institute of Scientific and Technical Information of China (English)

    滕飞

    2011-01-01

    本文对一给定的线性规划问题,分别利用统计分析软件SAS的0R模块和LINGO优化软件进行求解和分析,并对这两种数学软件在求解规划问题上的差异上的比较,得出了LINGO优化软件比较适合求解线性规划问题的结论.%In this paper, the writer adopts the statistical analysis software SAS/OR module and the LINGO optimization software to solve linear programming problems, and compares the differences.

  16. Scafom International BV v. Lorraine Tubes S.A.S.: a case review of changing circumstances under the United Nations Convention on International Sale of Goods (CISG of 1980

    Directory of Open Access Journals (Sweden)

    Amalina AHMAD TAJUDIN

    2014-12-01

    Full Text Available This paper analyses the Belgium Supreme Court decision of Scafom International BV v. Lorraine Tubes S.A.S. The case involved a contract of sale of volatile goods ie steel tubes whereby a fixed-price contract caused it to be unenforceable because of the 70% market price increase just before the goods were delivered to the buyer. While the seller requested for renegotiation, for a higher contract price, the buyer refused to come to terms with the former. The court, by virtue of the United Nations sales law, held that renegotiation was the appropriate remedy in such a situation. In addition, the paper tests the different possible outcomes of this decision under the English Sale of Goods Act 1979, as well as the US Uniform Commercial Code. The finding of this test proves that these two sales laws would have tackled the issue of volatile market differently from that of the United Nations’.

  17. 框架的五种重要运算方法及其SAS源代码%Five Important Operation Methods and the SAS Codes of These Methods for Frame

    Institute of Scientific and Technical Information of China (English)

    王萌; 罗纯; 纪忠杰; 张应山

    2012-01-01

    多边矩阵的定义主要基于框架,设计框架是应用多边矩阵理论最基础的部分。为了方便设计出各种复杂框架,现拓展了矩阵理论的相关运算方法,归纳了框架的五种重要运算方法,并提供了这些运算方法的SAS源代码。%The definition of the multilateral matrix is mainly based on the frames. So designing the frames is the basic part of applying multilateral matrix theory. To design complex frames conveniently, the correlative operation methods in the matrix theory are expanded and five important operation methods for frame are generalized. Finally, for other scholars to apply the methods conveniently, the SAS codes of these methods are provided.

  18. Reflexões sobre as transformações contemporâneas no trabalho do Assistente Social: estudo sobre a Superintendência de Assistência Social da Universidade de São Paulo SAS-USP

    OpenAIRE

    Negrão, Adriana Ribeiro

    2015-01-01

    Este estudo teve como objetivos problematizar e aprofundar a reflexão sobre os fenômenos contemporâneos da intensificação, precarização e informatização dos processos de trabalho no cotidiano das assistentes sociais da SAS-USP. O primeiro capítulo retrata a trajetória histórica da Universidade de São Paulo e da Superintendência de Assistência Social, bem como traz à cena do debate a assistência estudantil na perspectiva da viabilização do direito ao ensino superior público e...

  19. La notion de temporalité au cœur de l’analyse des discours représentés à l’oral : essai de typologie, procédés rhétoriques et portées argumentatives des DR dans le débat présidentiel français de 2007

    Directory of Open Access Journals (Sweden)

    Caillat Domitille

    2012-07-01

    Full Text Available Dans le cadre d’un débat, la représentation de propos peut être considérée comme une véritable « arme » rhétorique, tant le recours à ce procédé permet au locuteur de jouer de différentes retombées argumentatives. Aussi, à partir de la transcription de la rencontre entre Nicolas Sarkozy (NS et Ségolène Royal (SR lors du débat présidentiel de l’entre-deux tours de 2007, nous proposons-nous d’étudier les différentes formes de DR utilisées afin d’en dresser une typologie à visée argumentative. Pour ce faire, nous nous placerons dans une optique quelque peu divergente des classifications traditionnelles, puisque nous utiliserons la notion de « temporalité » — en tant que positionnement de l’énonciation de référence par rapport à l’intervention en cours — comme principal critère distinctif des occurrences et des effets dont celles-ci sont directement responsables. En plaçant de la sorte la temporalité au centre de l’étude des discours représentés (dorénavant DR, nous serons tout d’abord amenée à reconsidérer les critères traditionnellement pris en compte dans les classifications temporelles, avant de revenir sur l’importance de la nature des sources énonciatives de référence ; nous reviendrons en outre sur le critère de « virtualité » fréquemment utilisé comme un élément distinctif. Nous procéderons alors, dans le but d’expliquer au mieux la portée de chaque occurrence de DR, à un inventaire des diverses formes recensées, en conduisant pour chaque type de source énonciative une étude des différentes temporalités observables.

  20. Ifp's New Flexible Hydrocracking Process Combines Maximum Conversion with Production of High Viscosity, High Vi Lube Stocks Le nouveau procédé IFP d'hydrocraquage à haute flexibilité combine conversion maximum et production de bases, huile à haute viscosité et à indice de viscosité élevé

    Directory of Open Access Journals (Sweden)

    Hennico A.

    2006-11-01

    Full Text Available Institut Français du Pétrole (IFP has developed a new dual catalytic system for its hydrocracking process that enables high conversion to middle distillates and production of high viscosity, high VI lube stocks. Although the hydrocracking process is mainly devoted to the conversion of vacuum distillates, deasphalted oil or mixture of both into high quality middle distillates, it can also produce a residue, that after dewaxing will be a very high VI lube base oil. In this presentation major emphasis is put on the possibility to produce very high VI lubes with high viscosity thanks to the development of the new catalytic system. Large flexibility in feedstock selection and easy control of operating variables allow the production of all grades of lube oils associated with high quality middle distillates for a large range of conversion levels. L'Institut Français du Pétrole (IFP a mis au point, pour son procédé d'hydrocraquage, un nouveau système catalytique à 2 catalyseurs qui permet une forte conversion en distillats moyens et la production de fractions lubrifiantes à haute viscosité et indice de viscosité élevé. Si le procédé d'hydrocraquage est essentiellement utilisé pour la conversion de distillats sous vide, d'huile désasphaltée ou d'un mélange des deux en distillats moyens de haute qualité, il peut aussi produire un résidu qui, après déparaffinage, fournira une base pour lubrifiant à indice de viscosité très élevé. Cet article souligne particulièrement la possibilité de produire des lubrifiants à indice de viscosité très élevé et haute viscosité, grâce à ce nouveau système catalytique. Une grande flexibilité dans le choix des produits à traiter et la facilité de contrôle des paramètres opératoires permet la production de toutes les qualités d'huiles lubrifiantes associées à des distillats moyens de haute qualité, pour une large gamme de niveaux de conversion.

  1. La biblioteca en procés de canvi

    Directory of Open Access Journals (Sweden)

    Alonso Arévalo, Julio

    2016-06-01

    Full Text Available El context de les biblioteques està mutant de la mateixa manera que passa en altres entorns socials. Les biblioteques s'han d'adaptar a un món en què cada vegada més i més informació està en format digital, accessible en qualsevol moment i en qualsevol lloc. Per això les biblioteques estan redissenyant els seus espais i les seves regles per tal de donar cabuda als nous comportaments, necessitats i hàbits que demanen els usuaris i les seves comunitats. Per aquest motiu, moltes biblioteques estan creant espais rics amb eines i tecnologies avançades que inspiren i faciliten l'aprenentatge, el descobriment, la creació i l'experimentació. Entre les propostes més innovadores hi ha la que fa referència a la biblioteca com a generadora de contingut, un espai per a la creació i dinamització de la seva comunitat.El contexto de las bibliotecas está mutando al igual que ocurre en otros entornos sociales. Las bibliotecas deben adaptarse a un mundo en el que cada vez más y más información está en formato digital, accesible en cualquier momento y en cualquier lugar, por ello las bibliotecas están rediseñando sus espacios y sus reglas para dar cabida a los nuevos comportamientos, necesidades y hábitos que demandan los usuarios y sus comunidades. Por este motivo, muchas bibliotecas están creando espacios ricos con herramientas y tecnologías avanzadas que inspiran y facilitan el aprendizaje, el descubrimiento, la creación y la experimentación. Entre las propuestas más innovadoras está la relativa a la biblioteca como generadora de contenido, un espacio para la creación y dinamización de su comunidad.Like other social environments, libraries are being required to adapt to a world where information is becoming increasingly digitized and can be accessed at any moment in any place. For this reason many library institutions are redesigning the spaces in which they offer services and the rules by which they operate, tailoring these to suit the changing behaviour, needs and habits of users and communities. Many centres are creating spaces enhanced by advanced tools and applications that inspire and facilitate learning, discovery, creation and experimentation. One of the most innovative models for change considers the library as a vehicle for content generation and a space where communities can be created and promoted.

  2. La biblioteca en procés de canvi

    Directory of Open Access Journals (Sweden)

    Alonso Arévalo, Julio

    2016-06-01

    Full Text Available El context de les biblioteques està mutant de la mateixa manera que passa en altres entorns socials. Les biblioteques s'han d'adaptar a un món en què cada vegada més i més informació està en format digital, accessible en qualsevol moment i en qualsevol lloc. Per això les biblioteques estan redissenyant els seus espais i les seves regles per tal de donar cabuda als nous comportaments, necessitats i hàbits que demanen els usuaris i les seves comunitats. Per aquest motiu, moltes biblioteques estan creant espais rics amb eines i tecnologies avançades que inspiren i faciliten l'aprenentatge, el descobriment, la creació i l'experimentació. Entre les propostes més innovadores hi ha la que fa referència a la biblioteca com a generadora de contingut, un espai per a la creació i dinamització de la seva comunitat.El contexto de las bibliotecas está mutando al igual que ocurre en otros entornos sociales. Las bibliotecas deben adaptarse a un mundo en el que cada vez más y más información está en formato digital, accesible en cualquier momento y en cualquier lugar, por ello las bibliotecas están rediseñando sus espacios y sus reglas para dar cabida a los nuevos comportamientos, necesidades y hábitos que demandan los usuarios y sus comunidades. Por este motivo, muchas bibliotecas están creando espacios ricos con herramientas y tecnologías avanzadas que inspiran y facilitan el aprendizaje, el descubrimiento, la creación y la experimentación. Entre las propuestas más innovadoras está la relativa a la biblioteca como generadora de contenido, un espacio para la creación y dinamización de su comunidad.Like other social environments, libraries are being required to adapt to a world where information is becoming increasingly digitized and can be accessed at any moment in any place. For this reason many library institutions are redesigning the spaces in which they offer services and the rules by which they operate, tailoring these to suit the changing behaviour, needs and habits of users and communities. Many centres are creating spaces enhanced by advanced tools and applications that inspire and facilitate learning, discovery, creation and experimentation. One of the most innovative models for change considers the library as a vehicle for content generation and a space where communities can be created and promoted.

  3. Économie d'un procédé d'hydrolyse enzymatique et fermentation de la paille de blé pour la production d'alcool carburant Economics of a Process for Producing Alcohol Fuels by Enzymatic Hydrolysis and Fermentation of Wheat Straw

    Directory of Open Access Journals (Sweden)

    Arlie J. P.

    2006-11-01

    Full Text Available Après définition des grandes lignes d'un procédé de base d'hydrolyse-fermentation de la paille de blé, l'analyse de sensibilité montre que le rendement de l'hydrolyse a une grande importance sur les bilans énergétique et économique. Des rendements de l'ordre de 85 % permettent d'obtenir des valeurs d'investissement par tonne de pétrole économisée tout à fait comparables à celles obtenues par d'autres techniques de valorisation de la biomasse en alcool, telle la synthèse du méthanol obtenu après gazéification du bois à l'oxygène. The basic features of a process for production from cereal straw of an acetone-butanol mixture for use as a gasoline substitute are described. They include pretreatment and enzymatic hydrolysis of the substrate followed by fermentation of the sugars produced. A cost evaluation based on the performances of a reference process is presented. Then, an analysis of the sensitivity of the cost price of the process to the variation of the important parameters such as production capacity, enzyme productivity, hydrolysis yield is carried out. The energy balance of the process is presented.

  4. Application of SAS macro to evaluated multiplicative and additive interaction in logistic and Cox regression in clinical practices%实现logistic与Cox回归相乘相加交互作用的临床实践宏程序

    Institute of Scientific and Technical Information of China (English)

    聂志强; 欧艳秋; 庄建; 曲艳吉; 麦劲壮; 陈寄梅; 刘小清

    2016-01-01

    病例对照研究常采用条件或非条件logistic分析,生存资料分析常采用Cox比例模型,但多数文献仅纳入主效应模型,然而广义线性模型不同于一般线性模型,其交互作用分为相乘交互与相加交互作用,前者只有统计学意义而后者更符合生物学意义.笔者以SAS 9.4软件编写宏,在计算logistic与Cox相乘交互项同时计算交互对比度、归因比、交互作用指数指标及利用Wald、Delta、PL(profile likelihood)3种方法的可信区间评价相加交互作用,便于临床流行病学与遗传学大数据分析相乘相加交互作用时参考.%Conditional logistic regression analysis and unconditional logistic regression analysis are commonly used in case control study,but Cox proportional hazard model is often used in survival data analysis.Most literature only refer to main effect model,however,generalized linear model differs from general linear model,and the interaction was composed of multiplicative interaction and additive interaction.The former is only statistical significant,but the latter has biological significance.In this paper,macros was written by using SAS 9.4 and the contrast ratio,attributable proportion due to interaction and synergy index were calculated while calculating the items of logistic and Cox regression interactions,and the confidence intervals of Wald,delta and profile likelihood were used to evaluate additive interaction for the reference in big data analysis in clinical epidemiology and in analysis of genetic multiplicative and additive interactions.

  5. Evolution of Seismic Velocities in Heavy Oil Sand Reservoirs during Thermal Recovery Process Évolution des vitesses sismiques dans les réservoirs de sables bitumineux au cours des procédés de récupération thermique

    Directory of Open Access Journals (Sweden)

    Nauroy J.-F.

    2013-01-01

    Full Text Available In thermally enhanced recovery processes like Cyclic Steam Stimulation (CSS or Steam Assisted Gravity Drainage (SAGD, continuous steam injection entails changes in pore fluid, pore pressure and temperature in the rock reservoir, that are most often unconsolidated or weakly consolidated sandstones. This in turn increases or decreases the effective stresses and changes the elastic properties of the rocks. Thermally enhanced recovery processes give rise to complex couplings. 4D seismic surveys are currently conducted to delineate the steam-affected areas but the interpretation is difficult. However, it is essential for optimization of reservoir development. Numerical simulations have been carried out on a case study so as to provide an estimation of the evolution of pressure, temperature, pore fluid saturation, stress and strain in any zone located around the injector and producer wells. The approach of Ciz and Shapiro (2007 (Geophysics 72, A75-A79 has been used to model the velocity dispersion in the oil sand mass under different conditions of temperature and stress. A good agreement has been found between these predictions and some laboratory velocity measurements carried out on samples of Canadian oil sand. Results appear to be useful to better interpret 4D seismic data in order to locate the steam chamber. Dans les procédés de récupération des huiles lourdes par méthodes thermiques, comme ia stimulation cyclique par vapeur (CSS ou le drainage par gravité assisté par vapeur (SAGD, l’injection de vapeur en continu entraîne des changements de liquide de pores, de pression interstitielle et de température dans la roche réservoir, qui est constituée le plus souvent de sable non consolidés ou faiblement consolidés- Ces changements à leur tour augmentent ou diminuent les contraintes effectives et modifient les propriétés élastiques des roches. Les procédés de récupération par méthodes thermiques mettent en oeuvre des couplages

  6. Amélioration des procédés de craquage thermique des résidus par optimisation de la transformation des résines et des asphaltènes Improving Heat Treatment Processes for Residues by Optimizing the Transformation of Resins and Asphaltenes

    Directory of Open Access Journals (Sweden)

    Decroocq D.

    2006-11-01

    Full Text Available L'amélioration de procédés de traitement thermiques de coupes lourdes de pétrole en présence d'additifs susceptibles d'augmenter à la fois la qualité et le degré de conversion en limite de formation de coke est décrit. L'hydroviscoréduction du RSV Safaniya en présence d'un diluant aromatique donneur d'hydrogène (tétraline associé à un composé sulfuré (thiol, disulfure ou sulfoxyde permet l'obtention de conversions élevées sans production notable de coke et de gaz, ceci aussi bien en réacteur statique qu'en régime dynamique. Ces résultats sont confirmés par l'étude du traitement thermique de charges lourdes de natures diverses. Des essais menés sur pilote industriel montrent l'influence d'un additif soufré associé à une coupe LCO ou HCO sur la qualité de bases pour fuels commerciaux produites à partir d'un résidu sous vide de Safaniya. La caractérisation analytique des recettes de pyrolyses ou de certaines de leur fraction, par pyroanalyse oxydante, chromatographies liquides (SARA, GPC, spectroscopies RMN 1H et 13C , diffraction des rayons X, microscopies optiques et électroniques, met en évidence de profondes transformations de la matière hydrocarbonée et confirme l'effet de synergie entre les deux types d'additifs dans le traitement thermique de ces coupes lourdes.

  7. 计量资料非劣效临床试验样本量及把握度的计算与SAS程序实现%SAS programming for sample size and power calculation of measurement data in non-inferior trials

    Institute of Scientific and Technical Information of China (English)

    文世梅; 陈云飞; 刘华

    2013-01-01

    AIM: To calculate sample size and power of measurement data in non-inferior trials using SAS programming. METHODS;Two cal culation method, formula and SAS program ming, were compared based on examples and the SAS macro for power was given as well. RE SULTS: The calculation results of SAS program ming was consistent with the formula, and SAS programming can directly give the result was more convenient without looking-up table to ob tain the relevant parameters. CONCLUSION: It is helpful for investigator to have a better under standing at this programming to calculate sample size and power provided in this paper.%目的:利用SAS简易快速对计量资料非劣效临床试验进行样本量及把握度的计算.方法:比较公式及SAS编程两种计算方法,同时给出反推把握度的SAS宏程序.结果:公式和SAS程序两种计算方法的结果一致,利用SAS程序可以直接给出结果,无需要再进行查表获得相关参数,更简单、快捷.结论:利用本文提供的程序可以更好地帮助研究者理解与运用此程序进行样本量和把握度的估算,为此类新药临床试验服务.

  8. HyGenSys: a Flexible Process for Hydrogen and Power Production with Reduction of CO2 Emission HyGenSys : un procédé flexible de production d’hydrogène et d’électricité avec réduction des émissions de CO2

    Directory of Open Access Journals (Sweden)

    Giroudière F.

    2010-09-01

    Full Text Available This paper presents the latest development of HyGenSys, a new sustainable process and technology for the conversion of natural gas to hydrogen and power. The concept combines a specific steam reforming reactor-exchanger with a gas turbine. The heat necessary for the steam reforming reaction comes from hot pressurized flue gases produced in a gas turbine instead of a conventional furnace. Thanks to this high level of heat integration, the overall efficiency is improved and the natural gas consumption is reduced which represents an advantage with regard to economics and CO2 emission reduction. In addition to the efficient HyGenSys process scheme itself, the technology of the reactorexchanger also offers a high level of heat integration for even more energy saving. Two main alternatives are examined in order to meet two different requirements. The first one, named HyGenSys-0, focuses on the hydrogen production for the refining and petrochemical application. The second one named HyGenSys-1, concerns the centralized power production with pre-combustion CO2capture. In that case, the produced hydrogen is fully used to fuel a power gas turbine. HyGenSys-1 has been developed and optimised in CACHET, a European Community funded project. The CACHET electrical power objective was 400 MW at the minimum. HyGenSys-0 and HyGenSys-1 are described in detail with challenges and advantages compared to existing technologies. For both alternatives, the heart of the technology is the reactor-exchanger. The reactor-exchanger design relies on an innovative arrangement of bayonet tubes that allows, at large scale, multiple heat exchanges between hot pressurized flue gas, natural gas feed and hydrogen rich stream produced. Cet article présente les développements récents d’HyGenSys, nouvel éco-procédé de conversion du gaz naturel en hydrogène et électricité. Le concept combine un réacteur-échangeur spécifique de reformage à la vapeur avec une turbine à gaz

  9. Scale Effects in Laboratory and Pilot-Plant Reactors for Trickle-Flow Processes Les conséquences de l'extrapolation appliquée aux procédés à écoulement ruisselant réalisés en laboratoire et dans les réacteurs des unités-pilotes

    Directory of Open Access Journals (Sweden)

    Sie S. T.

    2006-11-01

    carry out meaningful process research on hydrotreating processes on the scale of micro-reactors. Les études et mises au point effectuées en laboratoire sont nécessairement effectuées à plus petite échelle que les réalisations commerciales. Dans le cas de la mise au point et de la commercialisation de la technologie d'un procédé nouveau, il faudra traduire les résultats obtenus en laboratoire pour la technologie envisagée à l'échelle commerciale; le problème est donc l'extrapolation vers le haut. Cependant, bien souvent, la technologie commerciale, pour ce qui touche au type de réacteur, est plus ou moins bien définie et les études de laboratoire s'attachent à produire des données permettant de prévoir le comportement qu'auront dans ce réacteur des catalyseurs nouveaux, de matières premières de substitution, etc. Dans bien des cas, étant donné la complexité de la composition de la matière première et la cinétique de réaction, il est impossible de mener la prévision en s'appuyant sur les données cinétiques et les modèles informatiques, de sorte qu'il n'y a pas d'autre solution que la simulation du réacteur commercial à l'échelle du laboratoire; le problème est donc l'extrapolation vers le bas. Du point de vue de l'efficacité des études de recherche et développement, pour les expériences en laboratoire, l'échelle devra être aussi petite que possible sans nuire à la signification des résultats. Le présent article examine certains problèmes liés à l'extrapolation vers le bas d'un réacteur à écoulement ruisselant telle qu'elle est appliquée dans les procédés d'hydrotraitement à des réacteurs de laboratoire de tailles différentes cinétiquement équivalents. Deux aspects principaux relatifs à des inégalités de dynamique des fluides résultant de différences d'échelle sont décrits plus en détail, i. e. les écarts par rapport à un écoulement idéal donnant lieu à un effet bouchon et au mouillage ou à l

  10. Statistical analysis of medical data using SAS

    CERN Document Server

    Der, Geoff

    2005-01-01

    An Introduction to SASDescribing and Summarizing DataBasic InferenceScatterplots Correlation: Simple Regression and SmoothingAnalysis of Variance and CovarianceMultiple RegressionLogistic RegressionThe Generalized Linear ModelGeneralized Additive ModelsNonlinear Regression ModelsThe Analysis of Longitudinal Data IThe Analysis of Longitudinal Data II: Models for Normal Response VariablesThe Analysis of Longitudinal Data III: Non-Normal ResponseSurvival AnalysisAnalysis Multivariate Date: Principal Components and Cluster AnalysisReferences

  11. SAS 3 observations of GX 1 + 4

    Science.gov (United States)

    Doty, J. P.; Lewin, W. H. G.; Hoffman, J. A.

    1981-01-01

    GX 1 + 4 is one of the brightest celestial sources of high-energy X-rays. It is a pulsar with a period of approximately 2 min (perhaps a multiple of 2 min), decreasing at a variable rate which, since 1971, has averaged approximately 2% per year, but which can be larger than 5% per year. This is the largest rate of decrease observed for any pulsar. The rate of decrease appears to be correlated with the luminosity, in support of the idea that the period decrease is produced by accretion torques acting upon a neutron star. No evidence is seen for a Doppler shift due to motion of the pulsar in a binary orbit; this is consistent with the results of optical observations which suggest that any orbital period is fairly long (months to years). The spectrum of GX 1 + 4 is measured as a function of pulse phase, as well as the phase-averaged total spectrum, and the average spectrum of the pulses alone. The shape of the average pulsed spectrum suggests that the pulsations may be produced by 'hot spots' which are a few hundred meters in extent, with temperatures of approximately 10 to the 8th K (kT being approximately equal to 8 keV).

  12. 基于SAS的全球外来医学媒介生物截获统计地图绘制%Drawing of a global statistical map of captured exotic medical vectors based on SAS system

    Institute of Scientific and Technical Information of China (English)

    裘炯良; 郑剑宁; 林军; 马立新

    2012-01-01

    目的 探索基于SAS的统计地图绘制方法,及其在出入境检验检疫系统卫生检疫外来媒介生物监测工作中的应用.方法 应用统计地图法并采用国际权威的统计分析标准软件SAS分析平台进行编程,实现外来媒介生物截获信息的分类统计、数据分析,以及在世界地图上的实时、动态、全自动标注.结果 计算机自动绘制世界地图,根据20个国家首都的经纬度数据在图中用星号(★)标注出相应的国家位置,并用蓝、黄、橙、红4种颜色分别代表截获的媒介生物数量等级.来自巴拿马、巴西、泰国等国家的外来媒介生物量均以蓝星标注,表明截获量相对较少;来自韩国、南非等国家的外来媒介生物量均以红星标注,提示来自这些国家的外来医学媒介生物截获量相对较多.结论 统计地图可以直观、简便、动态地呈现外来媒介生物截获量在不同国家的分布情况,有助于检验检疫部门及时、准确、合理地分配力量,重点加强媒介截获量较大的来源国卫生检疫监管工作.%Objective To explore the drawing method of a statistical map based on statistics analysis system (SAS) and its application in the surveillance of exotic medical vectors and risk analysis in entry - exit inspection and quarantine system. Methods The statistical map method based on SAS program was applied for the classification statistics and data analysis of exotic medical vectors, with real-time, dynamic and automatic marking on the world map actualized. Results A world map was automatically drawn by computer and the related data and messages were labelled real-timely, dynamically and automatically on the world map in different colours. The locations of the twenty countries covered in this study were marked as asterisk in the map based on the longitude and latitude degree values of the capitals in those countries. Blue, yellow, orange and red colours were used to represent the

  13. 高敏C反应蛋白水平与2型糖尿病患者亚临床动脉粥样硬化关系研究%Research on correlation between Hs-CRP levels and T2D patients' SAS

    Institute of Scientific and Technical Information of China (English)

    张邻川

    2012-01-01

    Objective To discuss the correlation between hs-CRP levels and T2D patients'atheroma.Methods 140 T2D patients were visited for follow-up,tested and divided into groups and the hs-CRP levels were compared as T2D patients with and without SAS and the healthy control group.Results The depths of CCA-TMT and FA-TMT and hs-CRP levels of T2DM with and without SAS were both higher than those of the control group(P < 0.05).The depths of CCA-TMT and FA-TMT and hs-CRP levels of T2DM with SAS were all higher than those of the T2DM without SAS(P < 0.05).Conclusion T2DM patients with SAS all go through sub-clinical inflammation condition of different degrees.Constant and chronic increase of hs-CRP levels is an independent risk factor for SAS occurrence.%目的 探讨高敏C反应蛋白水平与2型糖尿病患者亚临床动脉粥样硬化的关系.方法 通过对140例T2DM患者进行随访、检测、分组,比较T2DM患者伴SAS、不伴SAS与健康对照组的hs-CRP水平.结果 T2DM伴SAS组与无SAS组CCA-IMT、FA-IMT厚度及hs-CRP水平均明显高于对照组(P< 0.05); T2DM伴SAS组CCA-IMT、FA-IMT厚度及hs-CRP水平均高于无SAS组(P<0.05).结论 T2DM及伴有SAS患者和均有不同程度的亚临床炎症状态,持续、慢性的hs-CRP升高是T2DM患者发生SAS的独立危险因素.

  14. Anastrozole versus tamoxifen as adjuvant therapy for Japanese postmenopausal patients with hormone-responsive breast cancer: efficacy results of long-term follow-up data from the N-SAS BC 03 trial.

    Science.gov (United States)

    Aihara, Tomohiko; Yokota, Isao; Hozumi, Yasuo; Aogi, Kenjiro; Iwata, Hiroji; Tamura, Motoshi; Fukuuchi, Atsushi; Makino, Haruhiko; Kim, Ryungsa; Andoh, Masashi; Tsugawa, Koichiro; Ohno, Shinji; Yamaguchi, Takuhiro; Ohashi, Yasuo; Watanabe, Toru; Takatsuka, Yuichi; Mukai, Hirofumi

    2014-11-01

    Aromatase inhibitors are superior to tamoxifen as adjuvant therapy in postmenopausal patients with hormone-responsive breast cancer. We report the follow-up efficacy results from the N-SAS BC 03 trial (UMIN CTRID: C000000056) where anastrozole was compared with tamoxifen as adjuvant therapy in postmenopausal Japanese patients with hormone-responsive early breast cancer. The full analysis set contained 696 patients (anastrozole arm, n = 345; tamoxifen arm, n = 351). The log-rank test was used to compare the two groups in terms of disease-free survival (DFS) and relapse-free survival (RFS); Kaplan-Meier estimates were calculated. The treatment effects were estimated by Cox's proportional hazards model. To examine time-varying effect of hazard ratios, we estimated time-varying hazard ratios at time t [HR(t)] using data from time t up to 12 months. After a median follow-up of 98.5 months, hazard ratios (95% CIs) were 0.90 (0.65-1.24; log-rank p = 0.526) for DFS and 0.83 (0.56-1.23; log-rank p = 0.344) for RFS. Hazard ratios (95% CIs) for DFS and RFS up to 36 months were 0.69 (0.40-1.17) and 0.54 (0.27-1.06) and those after 36 months were 1.06 (0.70-1.59) and 1.05 (0.64-1.73), respectively. Time-varying hazard ratios for both DFS and RFS showed that hazard ratios were initially in favor of anastrozole and approached 1.0 at around 36 months. Superior efficacy of anastrozole to tamoxifen suggested by the initial analysis was not confirmed in the present analysis after a long-term follow-up period. Advantage of anastrozole was the greatest immediately after switching from tamoxifen and then decreased thereafter.

  15. PAI- 1 4G/5G Polymorphism in patients with SAS%睡眠呼吸暂停综合征患者PAI-1 4G/5G基因多态性分析

    Institute of Scientific and Technical Information of China (English)

    徐霞; 王言森; 高辉

    2001-01-01

    目的研究睡眠呼吸暂停综合症(SAS)患者纤溶酶原激活物抑制物-1(PAI-1)活性(PAI-1:A)及含量(PAI-1:Ag)与PAI-1 4G/5G基因多态性的关系.方法依据睡眠呼吸监测的结果,将实验对象分为2组,正常对照组与SAS组,分别测定其血浆PAI-1:A和PA1-1:Ag、PA1-1 4G/5G基因多态性(RFLP),并用SPSS软件包进行统计学分析.结果SAS患者4G/4G+4G/5G基因型出现频率显著高于对照组.4G/4G基因型PA1-1:A和PAI-1:Ag的水平最高,其次为4G/5G基因型,5G/5G基因型PAI-1:A和PAI-1:Ag的水平最低,经统计学检验差异显著.结论 PAI-1的基因型与PA1-1:A及PAI-1:Ag水平之间关系密切.SAS患者具有较高的4G/4G、4G/5G基因频率,血浆PAI-1:A及PAI-1:Ag水平亦较高,所以我们认为SAS患者罹患心血管疾病的危险性更高,但SAS与心血管疾病的相互关系尚待进一步研究.

  16. Les procédés ASVAHL thermiques et catalytiques sous pression d'hydrogène pour la conversion des bruts lourds et des résidus de bruts classiques Thermal and Catalytic Asvahl Processes under Hydrogen Pressure for Converting Heavy Crudes and Conventional Residues

    Directory of Open Access Journals (Sweden)

    Peries J. P.

    2006-11-01

    Full Text Available Cet article décrit les performances comparées des procédés ASVAHL thermiques (TERVAHL T, TERVAHL H, TERVAHL HC et catalytiques (HYVAHL F, HYVAHL C dans deux cas de traitement: - brut désessencié Boscan (base des études objectif Transport; - résidu sous vide Safaniya (base des études Raffinage de résidu. A travers ces résultats, l'importance de la quantité d'hydrogène fixée est mise en évidence. Elle joue sur la conversion obtenue et sur la qualité des résidus. L'introduction de catalyseur soluble ou en suspension catalytique TERVAHL HC (hydroviscoréduction catalytique ou l'utilisation d'un catalyseur supporté (hydrotraiternent HYVAHL favorisent l'activation de l'hydrogène. C'est la combinaison des réactions de craquage, de polycondensation et d'hydrogénation, et les conditions opératoires (températures, temps de séjour et pression qui définiront les limites de la conversion pour une stabilité donnée des résidus. This article describes the comparative performances of thermal ASVAHL processes (TERVAHL T, TERVAHL H, TERVAHL HQ and catalytic ASVAHL processes (HYVAHL F, HYVAHL C for two types of processing: (1 degasolined Boscan crude (basis of studies for transportation feasibility, and (2 Safaniya vacuum residue (basis of studies for residue refining. The results reveal the importance of the amount of fixed hydrogen, which affects the conversion obtained and the quality of the residues. The introduction of a TERVAHL HC soluble catalyst or one in catalytic suspension (catalytic hydrovisbreaking or the use of a supported catalyst (HYVAHL hydrotreatment enhances the activation of hydrogen. The combination of cracking, polycondensation and hydrogen reactions together with the operating conditions (temperatures, residence time and pressure are what will define the conversion limits for a given stability of residues.

  17. The Role of Attrition and Solids Recovery in a Chemical Looping Combustion Process Effet de l’attrition et de la récupération des particules dans le procédé de combustion en boucle chimique

    Directory of Open Access Journals (Sweden)

    Kramp M.

    2011-05-01

    Full Text Available In the present work, the steady-state behavior of a Chemical Looping Combustion process of interconnected fluidized bed reactors is simulated. The simulations have been carried out in two different scales, 50 kWth and 100 MWth. Attrition model derived from small scale laboratory experiments has been employed for the prediction of the process behavior in terms of attrition and Oxygen Carrier loss. Information on Oxygen Carrier characteristics and reaction kinetics were taken from literature. Realistic circulation mass flows of Oxygen Carrier particles are obtained and Oxygen Carrier losses are quantified. The large scale process looses significantly more Oxygen Carrier than the small scale process based on the same amount of thermal energy produced. Incomplete conversion in the air reactor could be identified as a critical point. Another issue is the fuel gas bypassing the Oxygen Carrier particles through bubbles in the large scale process which leads to lowered fuel conversions. The simulations indicate that a similar performance of a pilot scale and a large scale process is not guaranteed due to the scale-up effect on fluid dynamics. Furthermore, the simulations allow an assessment of the influence of the quality of the solids recovery system on the Oxygen Carrier loss. The distribution of the losses between possible origins is investigated and different changes in the solids recovery system are discussed regarding their potential to decrease the Oxygen Carrier loss. For example, the addition of a second-stage cyclone after the air reactor of the large scale process reduces the Oxygen Carrier loss significantly. Le présent travail propose un modèle de simulation en continu du procédé de combustion en boucle chimique constitué de deux lits fluidisés interconnectés. Les simulations ont été conduites à deux échelles 50 kWth correspondant à une installation pilote et 100 MWth correspondant à une installation industrielle. Un modèle d

  18. Procédé de suralcalinisation d'additifs détergents : rôle des promoteurs et détermination du régime de la réaction de surbasage Overbasing Process of Detergent Additives: Behavior of Promoters and Determination of Factors Controling the Reaction

    Directory of Open Access Journals (Sweden)

    Gallo R.

    2006-11-01

    Full Text Available Le mécanisme du procédé de suralcalinisation des huiles lubrifiantes est étudié. L'analyse du contrôle physique et (ou chimique est effectué dans ce procédé polyphasique, où une base solide (chaux, magnésie en suspension dans une solution, constituée d'une microémulsion, est carbonatée. Le carbonate non colloïdal est formé dans le milieu par une réaction successive à celle de la formation de carbonate colloïdal. La réaction, en présence (et en absence de détergent alkylarylsulfonique, n'est pas limitée par la cinétique chimique, mais par la diffusion des réactifs. Le méthanol, utilisé comme cotensioactif, influe sur la quantité de carbonate colloïdal sans augmenter la vitesse de surbasage. Les essais en milieu anhydre montrent que la présence d'une quantité très faible d'eau est indispensable. L'importance de la dilution par le solvant (xylène et la réactivité comparée MgO/Ca(OH2 sont discutées. Overbased (overalcalinized detergent additives are applied in lubrication of modern combustion engines : they neutralize the acidic products coming from combustion and fight corrosive wear. Overbased calcium sulfonates, the most widely used are made by carbonating CaO or Ca(OH2 in an hydrocarbon mixture (alkane + xylene containing a detergent (mostly alkylaryl-sulfonate and reaction promoters (water, alcohol, amine. The process is operated by several companies and a large amount of patent literature is reported on the subject [2]; however if the geometrical and physical nature of the colloidal carbonare particles formed in the process has been studied, very little is known on the fundamental aspects and on the mechanism of the overbasing process; this is what is described and discussed in this paper. Following previous kinetic results on experimental parameters associated to carbonatation, [4], further data are obtained applying kinetic graphs used in reactor analysis of complex reactions (Fig. 1. Plotting YA

  19. Hydrocraquage sous pression d'une huile de soja : procédé d'étude et allure générale de la transformation Soybean Oil Hydrocracking under Pressure: Process and General Aspect of the Transformation

    Directory of Open Access Journals (Sweden)

    Nunes P. P.

    2006-11-01

    Full Text Available Un procédé d'étude de l'hydrocraquage des huiles végétales en autoclave est décrit. Les principaux objectifs de cette étude sont relatifs à la transformation de l'huile de soja (composé modèle en essence et gazole, en limitant la formation de polymères et de coke. L'analyse des gaz et la chromatographie haute résolution de deux fractions résultant de la distillation sous vide de la phase liquide ont permis de mettre en évidence les principales étapes de l'hydrocraquage. Pour cette première approche du processus général, trois types d'hydrocraquages ont été utilisés : thermique et en présence d'un oxyde ou d'un catalyseur bifonctionnel performant (hydrogénant/craquant. Dans ce dernier cas, l'hydrogénation des doubles liaisons des chaînes latérales des triglycérides a été mise en évidence pendant le chauffage du réacteur jusqu'à environ 673 K, température à laquelle s'initie le véritable hydrocraquage. A cette température sont observées la décarbonylation/décarboxylation des acides gras (précédemment issus de la coupure des liaisons ester des triglycérides et une hydrogénolyse marquée en présence d'un catalyseur métallique. Il en résulte principalement des alcanes dont la structure linéaire est celle des acides gras initiaux. Le rendement global brut peut atteindre 83 % dans les conditions de température et de pression choisies, y inclus le pourcentage en fraction gazeuse (CO, CO2, C1-C4 A laboratory process for studying the hydrocracking of vegetable oils in a high-pressure batch reactor is described. The main goals of this study concern the transformation of soybean oil (used as a model into gasoline and diesel fuel fractions while limiting polymerization and coking. Gas analysis and high-resolution chromatography of two liquid fractions resulting from vacuum distillation were used to determine the main steps in the hydrocracking process. For this initial study of the general process, the three

  20. The Prospects of SAS Interferometry for Detection and Classification (SAS Interferometrie voor Detectie en Classificatie)

    Science.gov (United States)

    2008-10-01

    2001. [ 16] Chen, C. W., and Zebker, H.A., "Phase unwrapping for large SAR Interferograms: Statistical segmentation and generalized network models...Defensie en Veiligheid, Directie Directeur Markt , G.D. Klein Baltink 1 ex. TNO Defensie en Veiligheid, vestiging Den Haag, Manager

  1. Efficacité comparée de divers procédés physiques de séparation des argiles d'un sable de gisement A Comparison of Different Physical Processes for the Recovery of Clays from an Unconsolidated Sandstone

    Directory of Open Access Journals (Sweden)

    Yvon J.

    2006-11-01

    Full Text Available Divers procédés physiques (mixage, attrition, vibration ultra-sonique ont été utilisés pour désagréger et disperser les argiles d'un sable de gisement. Le traitement aux ultra-sons s'est avéré le plus efficace : après 10 min de vibration on récupère environ 1,5 fois plus de particules fines ( The characterizing of clays is an essential operation for understanding many problems encountered in production. It goes via a preliminary phase in which species are separated quickly and effectively without altering their nature. Chemical processes disperse clays by solubilizing their cements, amorphous compounds and poorly crystallized oxyhydroxides. But they attack fragile species and lead to mistaken results. Therefore, we have chosen various physical processes (mixing, attrition, ultrasonic vibration and compared their efficacy with a reservoir sand. This sand was a quartzose arenite in which 96. 6 % of the grains were between 63 µm and 2 mm. The < 40 µm fine fraction, obtained by wet sieving, represented 2. 44 % of the unprocessed sand, and the clayey fraction (kaolinite, illite, montmorillonite, interstratified illite-montmorillonite was 1. 20%. Mixing was done with a bladed stirer. 40 g of sand and 100 cm³ of demineralized water were stirred for 3 min at a speed of 3000 rpm. Attrition was done by two devices :(1 For attrition by rotation, 400 g of sand and 0. 5 liter of demineralized water were placed in a porcelain jar rotating at a speed of 37 rpm. Tests were performed with water alone and with the adding of a dispersant (0. 3 % sodium hexametaphosphate and a surfactant (0. 6 mole/liter of sodium sulfonate paraoctylphenyl. (2 Attrition by a Turbula TC2 mixer, which gave the jar a complex rotation movement including shaking and rhythmic rocking. 500 g of sand were thus processed in 1 literof 3 % sodium hexametaphosphate solution for varying times. Ultrasonic processing was done with a Sonifer 830 device. The probe was plunged into a

  2. Epuration des eaux usées de raffinerie par le procédé biologique des lits bactériens. Problèmes pratiques de l'exploitation Purifying Refinery Waste Water by the Bacterial Bed Biological Process. Practical Operational Problems

    Directory of Open Access Journals (Sweden)

    Leising M.

    2006-11-01

    Full Text Available Le traitement des eaux de raffinerie par le procédé des Iits bactériens constitue une solution intéressante. Néanmoins, il subsiste actuellement des problèmes pratiques d'exploitation, en particulier la tendance au colmatage des lits bactériens existants qui résulte d'un encrassement incontrôlé des garnissages en vrac. Après étude, il est confirmé que les hydrocarbures, les matières en suspension contenus dans l'effluent et une mauvaise évacuation de la biomasse sont à l'origine du problème. L'examen des possibilités de lutte contre ce phénomène permet de distinguer des mesures curatives et des mesure préventives. Les mesures curatives qui consistent à régénérer le garnissage par augmentation de la charge hydraulique, nettoyage chimique, ou nettoyage manuel ne donnent pas entière satisfaction. Parmi tes mesures préventives, l'une des méthodes consiset à réduire la charge polluante de l'effluent : les eaux usées phénolées sont dessalées, les eaux de désulfuration du gas oil (DGO et fluid cracking catalytic (FCC sont strippées, les soudes sont réinjectées dans le brut, les huiles récupérées juste en aval de leur rejet, les traitements primaires sont optimisés, notamment par installation de racleurs et de tambours oléophiles sur les séparateurs API et par un meilleur choix de floculants. Néanmoins, l'expérience montre que cette méthode ne permet que de retarder l'échéance du colmatage. Le meilleur moyen de lutte réside dans le choix du matériau de garnissage, ainsi que le montrent les essais pilotes comparatifs réalisés par l'Institut National de Recherche Chimique Appliquée (lRCHA et Compagnie Française de Raffinage (CFR. Ces essais, qui ont portés sur l'évolution de la densité du garnissage, les performances épuratoires et la qualité des boues montrent que le Cloisonyle, garnissage tubulaire, est probablement le matériau le mieux adapté. Refinery waste-water treatment by trickling

  3. Etude d'un procédé d'hydroliquéfaction du charbon pour la production simultanée de gaz et de carburant . . . . . Studies of a Coal Hydrogenation Process to Produce CO-Currently Gas and Gasoline

    Directory of Open Access Journals (Sweden)

    Franckowiak S.

    2006-11-01

    Full Text Available Un des principaux moyens de réintroduire le charbon dans le marché énergétique français est de le transformer en produits utiles comme le gaz de réseau ou les carburants. Les procédés d'oxyvapogazéification permettent d'obtenir un gaz de synthèse qui peut être ensuite converti en gaz riche ou en produits liquides. L'hydrogénation en phase liquide (ou hydroliquéfaction se présente pour le long terme comme une seconde voie qui offre des avantages spécifiques - taux de conversion du charbon et rendement élevés, - production directe de gaz de substitution (GNS et de carburant, - possibilité d'utilisation d'hydrogène provenant de l'électricité nucléaire. Un programme d'étude a été lancé avec la participation du Gaz de France (GDF, du Centre d'études et de recherches des Charbonnages de France (Cerchar, de l'institut Français du Pétrole (lFP et du Centre National de la Recherche Scientifique (CNRS dans le cadre du Groupe d'Étude de la Conversion du Charbon par Hydrogénation (GECH. Un banc d'essai d'hydroliquéfaction situé au Cerchar, d'un débit de 10 kg/h de mélange charbon-solvant, permet d'obtenir des hydrogénats dans des conditions variées et en présence de divers catalyseurs. L'étude de la valorisation de ces hydrogénats est effectuée dans les laboratoires de l'lFP. Les essais et les études effectués permettent d'envisager la production à volonté du GNS, de carburants ou des deux ensemble. Un modèle d'optimisation a été réalisé au GDF pour étudier et comparer les différentes filières en prenant en compte l'utilisation d'hydrogène d'électrolyse ou d'hydrogène produit sur place à partir du résidu de liquéfaction. One of the main ways to bring coal in the future french energy market is to transform it into valuable products. The oxygen steam gasification processes give a synthesis gas which can be converted into SNG or gasoline in a catalytic stage. The liquid phase hydrogenation process is a

  4. The Alkali/Surfactant/ Polymer Process: Effects of Slug Size, Core Length and a Chase Polymer Le procédé alkali/surfactant/polymère : effets de la taille du bouchon, de la longueur de la carotte et d'un polymère de déplacement

    Directory of Open Access Journals (Sweden)

    Green K. A.

    2006-11-01

    Full Text Available An experimental study was conducted to examine the effects of slug size, core length, and a chase polymer on the effectiveness of the alkali/surfactant/polymer (A/S/P process in recovering waterflood residual oil. Core flood experiments were conducted with unfired linear Berea sandstone cores. The tertiary oil recovery, oil cut, pressure drop, and chemical propagation were measured for each flood. Tertiary oil recovery significantly increased with the slug size up to 0. 5 of a pore volume. Increasing the slug size further resulted in a smaller incremental increase in oil recovery. A slight increase in tertiary oil recovery was obtained when small size A/S/P slugs were followed with achase polymer having a viscosity higher than the slug. The lack of oil recovery with small A/S/P slugs was due to the consumption and dilution of the injected chemicals, especially the synthetic surfactant, due to adsorption and dispersion. Increasing the core length by a factor of 4. 5 (from 9 to 40. 6 cm had no significant effect on tertiary oil recovery. Chemical propagation was found to be a function of core length (i. e. , core Peclet number and the size of the chase polymer slug. Increasing core length and employing a chase polymer maintained the integrity of the A/S/P slug by decreasing the effect of dispersion and minimizing the influence of viscous fingering at the tail of the A/S/P slug. Une étude expérimentale a été effectuée pour examiner les effets de la taille du bouchon, de la longueur de la carotte et de l'emploi d'un polymère de déplacement sur l'efficacité du procédé A/S/P (alkali/surfactant/polymère dans la récupération d'huile résiduelle par injection d'eau. Les expériences d'injection ont été faites avec des carottes rectilignes en grès de Berea vert. La récupération tertiaire du pétrole, la présence d'eau, la perte de charge et la propagation chimique ont été mesurées pour chaque injection. La récupération tertiaire du

  5. Analyse quantitative détaillée des distillats moyens par couplage CG/SM. Application à l'étude des schémas réactionnels du procédé d'hydrotraitement Quantitative Analysis of Middle Distillats by Gc/Ms Coupling. Application to Hydrotreatment Process Mechanisms

    Directory of Open Access Journals (Sweden)

    Fafet A.

    2006-11-01

    Full Text Available L'analyse détaillée des distillats moyens est une étape indispensable à la compréhension des mécanismes réactionnels et à la cinétique de certains procédés de raffinage comme l'hydrotraitement. Une nouvelle méthode associant, d'une part un couplage chromatographie en phase gazeuse/spectrométrie de masse (CG/SM et, d'autre part une analyse quantitative par famille chimique par spectrométrie de masse a été développée. La chromatographie en phase gazeuse, réalisée sur une colonne apolaire, effectue la distillation des composés présents dans le gazole et la spectrométrie de masse quantifie les familles chimiques par intervalle de nombre d'atomes de carbone ou de point d'ébullition. Elle permet d'accéder ainsi à la répartition par nombre d'atomes de carbone de chaque famille chimique (alcanes, cycloalcanes, hydrocarbures aromatiques à un ou plusieurs noyaux, hydrocarbures aromatiques soufrés. Cette méthode a été validée et appliquée à une charge et à une recette d'hydrotraitement. A detailed analysis of middle distillates is essential for understanding the reaction mechanism and for studying the kinetics of refining processes such hydrotreatment. In fact, when we see the complexity of saturated and aromatic hydrocarbon mixtures appearing in gas oil, we realize that it's necessary to have a very detailed analysis of those cuts to understand the mechanisms involved in refining processes and to be able to describe their kinetics. Each gas oil has a very different composition and therefore a specific reactivity. That is why we have tried to develop predictive kinetic models to avoid experimenting in pilot plants, which is very expensive. But, even if all the compounds of a gasoline (PI-200°C have now been identified and quantified, using gas chromatography (1, such is not the case for heavier cuts. Only an overall characterization can be made, by chemical family. The techniques employed are, for example, HPLC (3,4 or

  6. Monitoring of SAGD Process: Seismic Interpretation of Ray+Born Synthetic 4D Data Monitoring de procédé SAGD : interprétation sismique de données 4D synthétiques ray+Born

    Directory of Open Access Journals (Sweden)

    Joseph C.

    2012-03-01

    the synthetic (noise-free and noisy seismic data. Some of these attributes prove to be robust to the noise and to show some production effect. Possible trends between these attributes and the modelled reservoir/geomechanical properties (lithofacies, pressure, temperature, steam saturation, etc. are also evaluated. Finally, geobodies are extracted from the seismic attributes. L’objectif de cette étude est d’évaluer quelle information de production peut être déduite d’une campagne sismique 4D durant le procédé de récupération par injection de vapeur SAGD (Steam- Assisted Gravity Drainage. En plus des hétérogénéités réservoir d’origine géologique, de nombreux facteurs interagissent pendant la production thermique d’huile lourde et de bitume, ce qui complique l’interprétation des données sismiques 4D : variation de la viscosité de l’huile, des saturations en fluide, de la pression de pore, etc. Cette étude est basée sur le champ pétrolier Hangingstone de la formation McMurray en Athabasca (Canada. Dans des travaux antérieurs, un modèle statique initial (géologique, pétroacoustique et géomécanique avait été construit. Puis la production thermique d’huile lourde avait été simulée en mettant en oeuvre le couplage d’un modèle d’écoulement de réservoir et d’un modèle géomécanique. Les paramètres sismiques des roches saturées (densité, vitesses de compression et de cisaillement avaient alors été calculés à plusieurs étapes de la production à partir des paramètres mécaniques et de réservoir. À partir de ces résultats, une acquisition sismique est simulée à quatre états de production SAGD. Comme on s’intéresse aux réflexions sismiques en ondes de compression générées dans le réservoir, une modélisation sismique orientée cible est choisie. Cette modélisation est basée sur une approche ray+Born et permet de calculer la réponse sismique en estimant correctement les amplitudes sismiques en

  7. 药物Ⅰ期临床试验计量资料统计分析自动报表的SAS实现%Statistical analysis process by SAS software to realize automatically statements of measurement data in phase Ⅰ clinical trials

    Institute of Scientific and Technical Information of China (English)

    段锋; 魏振满; 陈大为; 朱珍真; 屠舒; 毕京峰; 李文淑; 孙斌

    2013-01-01

    Objective To realize automatically statements of measurement data in phase I clinical trials by SAS software. Methods Based on the SAS software, we used its functions, such as spliting table, statistical analysis, choosing results, transposing table, mergering tables horizontally or lengthways, to built statements of measurement data step by step. Results The statistical analysis results were imported to EXELE form automaticlly as report requirement. Conclusion The process is accurate and reliable, and saves time and effort. It is suitable for the non-professional statistical researchers to realize automatically statements of measurement data.%目的 借助SAS软件实现Ⅰ期临床试验计量资料统计分析的自动报表.方法 基于SAS软件,应用其拆分表格、统计分析、结果选择、表格转置、横向合并表格、纵向合并表格等程序逐步导出报表.结果 借助EXELE表格成功实现药物Ⅰ期临床试验计量资料统计分析结果的自动报表.结论 该过程省时省力,准确可靠,为非统计专业医学研究人员提供了一种简便、可靠的自动报表方法.

  8. Récupération des hydrocarbures des pieds de bacs provenant de la démixtion des mélanges méthanol-supercarburant. Application du procédé de séparation par coalescence Recovery of Hydrocarbons from Bottoms of Storage Tanks Coming from the Demixing of Methanol/Premium-Gasoline Blends. Application of the Coalescence-Separation Process

    Directory of Open Access Journals (Sweden)

    Hoornaert P.

    2006-11-01

    Full Text Available Une solution technique et économique a été mise au point pour traiter les pieds de bacsprovenant de la démixtion de mélanges méthanol - supercarburant au contact de traces d'eau. Le procédé consiste à provoquer une deuxième démixtion par addition d'eau à la phase à traiter. Les hydrocarbures ainsi relargués sont séparés parfaitement en utilisant un coalesceur à résines oléophiles. Il est ainsi possible de récupérer et de recycler la quasi-totalité des hydrocarbures contenus dans lespieds de bacs . L'effluent aqueux résiduel chargé en alcool peut, soit être recyclé, soit traité par la station de traitement d'eaux de la raffinerie. A technical and economic solution has been developed for processing bottoms of storage tankscoming from the demixing of methanol/premium-gasoline blends in contact with traces of water. The process consists in producing a second demixing by the addition of water to the phase to be processed. The hydrocarbons thus salted out are effectively separated by an oleophilic-resin coalescer. In this way almost all of the hydrocarbons contained in the bottoms of storage tankscan be recovered and recycled. The residual aqueous effluent containing alcohol can either be recycled or processed by the waste-water treatment station of the refinery.

  9. 基于SAS的出入境交通工具食源性疾病暴发流行快速溯源调查研究%Tracing survey based on SAS on food-borne disease outbreaks on entry-exit transport

    Institute of Scientific and Technical Information of China (English)

    裘炯良; 郑剑宁; 施惠祥; 张锜

    2012-01-01

    Objective To explore the tracing survey of food-bome disease outbreaks on entry-exit conveyances. Methods Four kind of chi square tests were employed for the analysis of food-bome disease outbreaks on the passenger liner after using relative epidemical survey tables. All of the procedures were executed by computer based on SAS program. Results The latent period was 28.94 h and exposure date was estimated as 9:33 on Sep. 5, 2009. Fresh milk was recognized as contaminated food, the value of OR was 9.03(93% CI = 2.2-33.63). Conclusion The tracing survey of food-borne disease outbreaks and relative SAS programs can provide a convenient, quick and effective tool for the prevention and control of food-bome diseases.%[目的]建立基于数据统计分析系统(SAS)的出入境交通工具食源性疾病暴发流行快速溯源调查方法.[方法]应用4种x2检验法,结合食源性疾病暴发流行调查样表,分析某口岸国际大型豪华邮轮上暴发的食源性疾病.并采用国际权威的统计分析标准软件SAS分析平台进行编程实现.[结果]经流行病学快速溯源调查,潜伏期为28.94h,暴露日期估计为2009年9月5日9时33分,鲜奶作为污染食品列为高风险因素,其OR值为9.03 (95% Cl=2.2~33.63).[结论]食源性疾病暴发流行快速溯源调查方法及SAS程序为口岸食源性疾病的防控提供了一种简便、快捷且客观有效的工具.

  10. Synthèse directe du 1,1-diméthoxyméthane à partir de méthanol moyennant une modification mineure du procédé de production de formaldéhyde sur catalyseurs FeMo Direct Synthesis of 1,1-dimethoxymethane from Methanol by Minor Modification of the Formaldehyde Production Process over FeMo Catalysts

    Directory of Open Access Journals (Sweden)

    Gornay J.

    2010-09-01

    Full Text Available La réaction d’oxydation ménagée du méthanol sur catalyseurs purement redox conduit principalement à la formation de formaldéhyde. Sur des catalyseurs FeMo optimisés, des sous-produits très minoritaires tels que l’acide formique et les oxydes de carbone (COx sont également détectés. Dans le cas de catalyseurs possédant en outre des propriétés acides, des réactions de condensation/déshydratation viennent s’ajouter au schéma réactionnel d’oxydations consécutives, ce qui génère des produits supplémentaires tels que le 1,1-diméthoxyméthane (DMM, aussi appelé méthylal, le diméthyléther ou encore le formiate de méthyle. Parmi ces produits, le DMM possède un intérêt industriel particulier. En effet, de par ses propriétés physiques (très bon solvant, basse viscosité, faible tension superficielle, etc., ses débouchés englobent de nombreuses applications comme solvant vert, intermédiaire de synthèse, voire carburant, en remplacement des produits issus de la pétrochimie. La méthode de synthèse conventionnelle du DMM fait appel à 2 étapes : – production du formaldéhyde et, – réaction par catalyse acide entre le formaldéhyde et le méthanol pour finalement former le DMM. Cependant, afin de réduire les coûts de production du DMM, la mise au point d’un catalyseur et d’un procédé idoine permettant sa synthèse directe sont nécessaires. Comme susmentionné, sur un catalyseur de type FeMo, l’oxydation du méthanol conduit à la formation très majoritaire de formaldéhyde. Ce procédé utilise une faible pression partielle de méthanol, la zone de composition riche en méthanol – hors diagramme d’explosivité – n’étant pas exploitée. En nous plaçant justement dans cette zone riche en méthanol, nous avons observé, sur ce même catalyseur FeMo, la meilleure productivité en DMM jamais reportée dans la littérature (4.6 kgDMM.h−1.kgCat−1 à 553 K avec une conversion de m

  11. Buffered Versus Non-Buffered Lidocaine With Epinephrine for Mandibular Nerve Block: Clinical Outcomes.

    Science.gov (United States)

    Phero, James A; Nelson, Blake; Davis, Bobby; Dunlop, Natalie; Phillips, Ceib; Reside, Glenn; Tikunov, Andrew P; White, Raymond P

    2017-04-01

    Outcomes for peak blood levels were assessed for buffered 2% lidocaine with 1:100,000 epinephrine compared with non-buffered 2% lidocaine with 1:100,000 epinephrine. In this institutional review board-approved prospective, randomized, double-blinded, crossover trial, the clinical impact of buffered 2% lidocaine with 1:100,000 epinephrine (Anutra Medical, Research Triangle Park, Cary, NC) was compared with the non-buffered drug. Venous blood samples for lidocaine were obtained 30 minutes after a mandibular nerve block with 80 mg of the buffered or unbuffered drug. Two weeks later, the same subjects were tested with the alternate drug combinations. Subjects also reported on pain on injection with a 10-point Likert-type scale and time to lower lip numbness. The explanatory variable was the drug formulation. Outcome variables were subjects' peak blood lidocaine levels, subjective responses to pain on injection, and time to lower lip numbness. Serum lidocaine levels were analyzed with liquid chromatography-mass spectrometry. Statistical analyses were performed using Proc TTEST (SAS 9.3; SAS Institute, Cary, NC), with the crossover option for a 2-period crossover design, to analyze the normally distributed outcome for pain. For non-normally distributed outcomes of blood lidocaine levels and time to lower lip numbness, an assessment of treatment difference was performed using Wilcoxon rank-sum tests with Proc NPAR1WAY (SAS 9.3). Statistical significance was set at a P value less than .05 for all outcomes. Forty-eight percent of subjects were women, half were Caucasian, 22% were African American, and 13% were Asian. Median age was 21 years (interquartile range [IQR], 20-22 yr), and median body weight was 147 lb (IQR, 130-170 lb). Median blood levels (44 blood samples) at 30 minutes were 1.19 μg/L per kilogram of body weight. Mean blood level differences of lidocaine for each patient were significantly lower after nerve block with the buffered drug compared with the

  12. El Administrador de Hecho -SAS- frente al Director Oculto

    Directory of Open Access Journals (Sweden)

    María Mónica Pino Sonalo

    2010-06-01

    Full Text Available Con el fin de generar una postura crítica en torno a la consagración del administrador de hecho en la ley 1258 de 2008 como figura novedosa del Ordenamiento Jurídico colombiano, los autores en esta ocasión han hecho un recorrido sobre la noción del administrador de hecho y del administrador oculto alrededor del Derecho Comparado, para determinar su aplicación y consecuencias jurídicas en nuestro ordenamiento jurídico, como unas figuras tendientes a la extensión de la responsabilidad de los administradores de sociedades.

  13. Provider Specific Data for Public Use in SAS Format

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Fiscal Intermediary maintains the Provider Specific File (PSF). The file contains information about the facts specific to the provider that affects computations...

  14. SAS Launches Biometric Identification at Airports All Over Sweden

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Scandinavian Airlines is to launch a new biometric identification system throughout Sweden.When traveling, your fingerprint will be matched to your check-in baggage. This makes the check-in process easier and improves security. The new technology will be launched during November and December at almost all airports served by Scandinavian Airlines in Sweden.

  15. A handbook of statistical graphics using SAS ODS

    CERN Document Server

    Der, Geoff

    2014-01-01

    An Introduction to Graphics: Good Graphics, Bad Graphics, Catastrophic Graphics and Statistical GraphicsThe Challenger DisasterGraphical DisplaysA Little History and Some Early Graphical DisplaysGraphical DeceptionAn Introduction to ODS GraphicsGenerating ODS GraphsODS DestinationsStatistical Graphics ProceduresODS Graphs from Statistical ProceduresControlling ODS GraphicsControlling Labelling in GraphsODS Graphics EditorGraphs for Displaying the Characteristics of Univariate Data: Horse Racing, Mortality Rates, Forearm Lengths, Survival Times and Geyser EruptionsIntroductionPie Chart, Bar Cha

  16. Marginal maximum likelihood estimation in polytomous Rasch models using SAS

    DEFF Research Database (Denmark)

    Christensen, Karl Bang; Olsbjerg, Maja

    2013-01-01

    Dansk radiohistorie er på mange måder et uskrevet kapitel. Selvom der findes flere udgivelser fra Statsradiofonien selv og en dansk mediehistorie i fire bind, henligger mange centrale problemstillinger endnu i historiens mørke. Det vil nærværende afhandling søge at råde bod på med et fokus på tid...

  17. Nueva evidencia sobre la Statistical Anxiety Scale (SAS

    Directory of Open Access Journals (Sweden)

    Amparo Oliver

    2014-01-01

    Full Text Available Las asignaturas relacionadas con la estadística suelen tener problemas de rendimiento académico. La ansiedad se relaciona de forma negativa con el rendimiento y en particular, la ansiedad estadística puede ser un constructo clave en la mejora de la enseñanza de esta materia y afines. La Statistical Anxiety Scale (Vigil-Colet, Lorenzo-Seva y Condon, 2008 se creó con la pretensión de ser útil para predecir el rendimiento académico en estadística. Se fundamenta en tres dimensiones de ansiedad referidas a tres aspectos específicos: respecto al examen, cuando se pide ayuda en la comprensión de estadística y en el proceso de interpretación de resultados. Esta estructura de tres factores fue hallada en un primer momento por los autores de la escala y en una primera validación corroborada en estudiantes italianos y españoles. El presente estudio pretende añadir nueva evidencia sobre la fiabilidad y validez de la escala, empleando en el estudio de fiabilidad técnicas estadísticas robustas, y ampliando el estudio de la validez respecto a su principal criterio, el rendimiento académico, ya que no puede ser considerado sinónimo de autoeficacia.

  18. Plan de negocio para Tamarindo Seco S.A.S

    OpenAIRE

    Salazar Briceño, Julián Danilo; Vargas Gallego, Daniel Felipe; Lotta Gamba, Sebastián Rodrigo

    2017-01-01

    El planteamiento inicial del plan de negocios para Tamarindo Seco tiene como objetivo encontrar oportunidades de negocio con los productos actuales para involucrase y aportar al sector de consumo masivo en lo que se refiere a la alimentación saludable, con el único fin de cumplir un propósito superior, promover una cultura medio ambiental sostenible a través de la modificación en el manejo que se le da a los desperdicios que genera el consumo masivo de alimentos en Colombia y la región. Tenie...

  19. Spa Rituales Ancestrales AüA S.A.S.

    OpenAIRE

    Lozano Socarrás, Rosa Marina

    2013-01-01

    Las practicas ancestrales de las culturas precolombinas cada día son mas validas en su aplicación actual para la medicina alternativa, orientada al bienestar y la salud, es un hecho que en los últimos años se observa un gran crecimiento de endemias de estrés que se presentan bajo determinadas circunstancias propias del sistema actual de vida urbana y actividades cotidianas, ocasionando recargas de tensión como respuesta a la supervivencia en un mundo agitado. La somatizacion del estrés se tra...

  20. Symposium on atomic spectroscopy (SAS-83): abstracts and program

    Energy Technology Data Exchange (ETDEWEB)

    1983-09-01

    Abstracts of papers given at the symposium are presented. Session topics include: Rydbergs, optical radiators, and planetary atoms; highly ionized atoms; ultraviolet radiation; theory, ion traps, and laser cooling; beam foil; and astronomy. (GHT)