... after blisters form If you have Stevens-Johnson syndrome, several days before the rash develops you may experience: Fever Sore mouth and throat Fatigue Cough Burning eyes When to see a doctor Stevens-Johnson ...
Brodie, Carolyn S.
Describes the life of Steven Kellogg, a children's book illustrator and writer. Includes extension ideas for school library media center activities related to his works and presents a selected annotated bibliography in chronological order, videos, and biographical information. (LRW)
Steven Weinberg visiting the ATLAS cavern accompanied by Peter JenniIt was no surprise that the CERN audience arrived early in the Globe of Science and Innovation for the colloquium on 7 July. Nobel laureate Steven Weinberg is one of the major contributors to the Standard Model of particle physics. He received the Nobel Prize for Physics in 1979 for his work on the unified theory of the electromagnetic and weak interactions, one of the essential pillars of the Standard Model. After lunch at CERN and a visit to ATLAS, Weinberg gave a colloquium on "The Quantum Theory of Fields: Effective or Fundamental" to a packed audience. In his talk, he looked at how the use of quantum field theory in particle physics has fluctuated in popularity since Paul Dirac first introduced the approach to describe the interaction of particles with electromagnetic fields in the late 1920s. In particular, he posed the question: Is quantum field theory fundamental or does it a...
duced in this issue. Steven Vogel was an eminent American biophysicist. ... as unusual and remarkable as his own work. He pre- .... called Reynolds stress, after the scientist who taught us to think in this ... PES Institute of Technology. Campus.
Inglise disainerist James Stevensist (sünd. 1962) ja tema tegevusest. J. Stevens 2000. a. Amsterdamis tehtud intervjuus koos Jon Bainsi ja Kim Bulliga 1995. a. Londonis avatud Interneti-agentuurist Obsolete, 1996-2000 tegutsenud Interneti-kohvikust Backspace, mittekommertsiaalse juhtmeteta nerworki Consume.net rajamisest Londonis
Steven Hawking is seen meeting with CERN's Director-General, Robert Aymar. Hawking visited CERN between 24 September and 1 October 2006. During his stay he gave two lectures and toured the LHC, which may provide insights into Hawking's most famous area of study, black holes.
National Oceanic and Atmospheric Administration, Department of Commerce — The Magnuson-Stevens Fishery Conservation and Management Act (MSA) is the primary law governing marine fisheries management in U.S. federal waters. It has since been...
Howell, W.R.; Knight, A.L.; Scruggs, H.J.
We have reported a case of classic Stevens-Johnson syndrome in association with treatment using a cobalt radiation therapy unit. Previous reports of such an association have been extremely rare. At the time of the reaction, the patient's only medications were methyldopa and trichlormethiazide. Other drugs in the thiazide class have been associated with such a reaction. We feel this is an unlikely association in our patient, however, because she had been on trichlormethiazide for a number of years. This report suggests the role of radiotherapy as a rare cause of Stevens-Johnson syndrome. 14 references
Steven Spielbergi raskused J.M. Barrie "Peeter Paani" ekraniseerimisel, tulemuseks mängufilm "Hook" : Ameerika Ühendriigid 1991. Järgneb 16. aug. 2004, lk. 38 pealkirja all "Rahulolematu Steven Spielberg"
Caraban Gonzalez, Noemi
Steven William Moffat, OBE is a Scottish television writer and producer, known for his work as showrunner, writer and producer of the British television series Doctor Who and Sherlock. Susan "Sue" Nicola Vertue is an English television producer, mainly of comedy shows, including Mr. Bean and Coupling.
Kaur-Knudsen, Diljit; Zachariae, Claus; Thomsen, Simon Francis
Stevens-Johnson syndrome and toxic epidermal necrolysis are acute mucocutaneous diseases primarily due to drug intake. The diseases are characterised by the separation of epidermis from dermis which can be life-threatening. Mortality is often caused by sepsis and multiple organ failure. The most...
Holfinger, Steven; Roy, Asim; Schmidt, Markus
We present the case of a 21-year-old woman in whom Stevens-Johnson syndrome (SJS) developed after initiation of armodafinil. Although this rare and life-threatening reaction is listed on armodafinil's label, no cases have been reported in the literature. This case, in addition to an update of the drug's label after post-marketing research, both support the link between armodafinil and SJS. Providers should maintain a high clinical suspicion for SJS when starting therapy to minimize associated morbidity and mortality by discontinuing armodafinil at the onset of first symptoms. © 2018 American Academy of Sleep Medicine.
Keywords. Steven Vogel, biomechanics, Péclet number, diffusion, advection, transport. Abstract. Steven Vogel was a pinoneer in applying principles of mechanics to diverse living systems. This article first provides a brief overview of his career. It then reviews the concepts of P´eclet number and Reynolds number which are ...
Stevens-Johnson Syndrome is an uncommon life threatening disease generally induced by drugs. Antibiotics, mainly sulphonamides, are the most involved drugs in Stevens-Johnson Syndrome in children. Co-amoxiclav is a well tolerated antibiotic. It has never been reported to cause, lonely this syndrome in children.
REVIEW. Introduction. Stevens-Johnson syndrome (SJS) and toxic epidermal ... that affect the skin and mucous membranes. ... Open Access article distributed under the terms of the .... pathogenic components are removed from plasma. The.
Two autographs given to author by professor Cecile Dewitt and Robert Hawking (the son of Steven Hawking for his father) in 1987 during the Quantum Gravity Seminar in Moscow are presented. The first was given during a visit to Physical Institute of the Academy of sciences of the USSR, where a seminar held in the Theoretical department. the second was given during a lunch with Steven Hawking, Andrei Linde and Robert Hawking at the 2-nd floor of the Conference floor.
Marco-Del Río, José; Domingo-Chiva, Esther; Cuesta-Montero, Pablo; Valladolid-Walsh, Ana; García-Martínez, Eva María
We describe a recent case of Stevens-Johnson Syndrome. A 49-year-old man was admitted to the Intensive Care Unit of an Anaesthesia and Resuscitation Department because of a Fournier gangrene that derived in a sepsis, ventilator-associated pneumonia, and renal failure. He was under treatment with cefepime and suffered a generalized status epilepticus, so started treatment with phenytoin. The next day he developed a "maculous cutaneous eruption in trunk and lower limbs" compatible with a Stevens-Johnson Syndrome. Stevens-Johnson Syndrome is a very severe and potentially fatal multiorganic disease, especially when present in critically ill patients, with a strong drug-related etiology, especially with antiepileptic drugs.
Numerical tables of products of tensor (Racah) operators, Rl,m(J), and Stevens operators Olm(J), working within a J-multiplet are given as a function of X=J(J+1). Examples of the use of the tables, such as the calculation of commutation relations and thermal averages are given.......Numerical tables of products of tensor (Racah) operators, Rl,m(J), and Stevens operators Olm(J), working within a J-multiplet are given as a function of X=J(J+1). Examples of the use of the tables, such as the calculation of commutation relations and thermal averages are given....
Justice John Paul Stevens of the United States Supreme Court has ruled on obscenity cases in seven instances since his appointment. His rulings reveal that he regards obscenity as a nuisance rather than as a danger threatening to undermine the nation's morality, that he supports a nationwide standard to adjudicate obscenity cases, and that he…
Background. Stevens-Johnson syndrome (SJS) is an acute life-threatening condition often elicited by drugs. The government's indecisiveness in deciding to stop the use of nevirapine (NVP) in HIV-infected pregnant women owing to the increase of SJS among this population group in South Africa prompted this investigation ...
Marco Benoit Carbone
Full Text Available Steven Poole is the author of Trigger Happy (2000. New York, NY: Arcade Publish, Unspeak (2006. New York, NY: Grove Press, and You Aren’t What You Eat (2012. In press. He has written extensively on books, culture, and videogames for The Guardian and other publications.
American Psychologist, 2009
Steven F. Maier, winner of the Award for Distinguished Scientific Contributions, is cited for his work in the fields of learned helplessness; cytokines, depressed mood, and cognitive interference; and the brain structures that produce and counteract learned helplessness. In addition to the citation, a biography and selected bibliography of Maier's…
Laasik, Andres, 1960-2016
Oscari võitnud dokumentaalfilm "Need viimased päevad" ("The Last Days") : režissöör James Moll : Tootja Steven Spielbergi loodud Survivors of the Shoah Visual History Foundation : Ameerika Ühendriigid 1999. Filmi esitlusest Eesti Vabariigi Välisministeeriumis
Aug 26, 2016 ... Steven Vogel was a pinoneer in applying principles of mechanics to diverse living systems. This article first provides a brief overview of his career. It then reviews the concepts of P´eclet number and Reynolds number which are helpful in appreciating the Classics article by Vogel reproduced in this issue.
Presents a profile of Steven Kellogg, an illustrator of children's books. Gives an overview of his career discussing how he got started and broke into the scene. Describes some of the books he has illustrated and relates his experiences with those books. (SG)
Berry, John N., III
This article profiles Steven L. MacCall, winner of "Library Journal's" 2010 Teaching Award. An associate professor at the School of Library and Information Studies (SLIS) at the University of Alabama, Tuscaloosa, MacCall was nominated by Kathie Popadin, known as "Kpop" to the members of her cohort in the online MLIS program at SLIS. Sixteen of…
Jun 1, 2014 ... of Stevens-Johnson syndrome highlights the dilemmas and complications that may arise when prescribing multiple medications in HIV-associated ... HIV enters the central nervous system early in the course of HIV ... Affected individuals with SJS/TEN are genetically predisposed to developing severe ...
Ivo Cavalcanti Pita Neto
Full Text Available Among the severe reactions to medications, immune-mediated Mucocutaneous Disorders are widely represented. Steven-Johnson’s syndrome, or great multiform erythema, appears as a systemic disturbance, involving the skin and mucous membranes, and is related to several factors, such as, viral or bacterial infections and particularly the administration of medicines, in general painkillers and antibiotics. The objective of this article is report the onset of ulcerative vesicle –blister lesions in the regions of the lips, gums, tongue and genital mucosa membrane in a 26 year-old patient, a leukoderm man, being treated with sulfamethoxazole trimethoprim for a respiratory infection, after being diagnosed as having the Steven-Johnson syndrome. SSJ1 558187121279.
Stevens -Johnson Syndrome and Toxic Epidermal Necrolysis Brittany L. Lenz, MD, Andrew T. Patterson, MD, Amanda J . Laska, MD, Patrick J . Brown, MD, and...59 MDW/SGVU SUBJECT: Professional Presentation Approval 8 DEC 2016 1. Your paper, entitled HLA-B Sequencing in Patients with Stevens -Johnson...PATIENTS WITH STEVENS -JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROL YSIS 2. FUNDING RECEIVED FOR THIS STUDY? DYES rgj NO FUNDING SOURCE: I I 3. IS THIS
Full Text Available Wallace Stevens’s “The Man with the Blue Guitar” (1937 is widely recognized as one of the most important and influential poems of the 20th century. Inspired by Picasso’s painting The Old Guitarist, the poem in turn inspired Michael Tippett’s sonata for solo guitar, “The Blue Guitar” (Tippett 1983 and David Hockney’s The Blue Guitar: Etchings by David Hockney who was inspired by Wallace Stevens who was inspired by Pablo Picasso (Hockney and Stevens 1977. Central to “The Man with the Blue Guitar,” the metaphor of the musical instrument as a transformational symbol of the imagination is common in Stevens’s poems. The structure of “The Man with the Blue Guitar,” according to J. Hillis Miller, is the structure of stream-of-consciousness. Stevens’s poem creates what has been called “the deconstructed moment in modern poetry,” “an attempt to project a spatialized time that can be viewed from the privileged position of a timeless, static moment capable of encompassing a life at a glance” (Jackson 1982. This consciousness, which Derrida refers to as the “trace,” Stevens calls “the evasive movement of language.” The trace is the perception of the absence of meaning after the word or perception has passed, the glimpse of a hidden meaning that immediately vanishes. Stevens’s poem influenced not only other poets, artists and composers; references to and echoes of his ideas and techniques can be seen in popular music and culture well into the 21st century.
Emberger, Michael; Lechner, Arno Michael; Zelger, Bernhard
To the best of our knowledge, Stevens-Johnson syndrome (SJS) has not been reported previously as an adverse reaction to Malarone, which is a combination of atovaquone and proguanil hydrochloride used for antimalarial prophylaxis and therapy. We describe a 65-year-old patient who had SJS with typical clinical and histopathological findings associated with the use of Malarone prophylaxis for malaria. This report should alert physicians to this severe cutaneous reaction, and Malarone should be added to the list of drugs that can potentially cause SJS.
... Management Act (Magnuson-Stevens Act) Provisions; Fishing Vessel, Fishing Facility and Individual Fishing... Fisheries Finance Program (FFP or the Program) provides long-term financing to the commercial fishing and...) lending program, 16 U.S.C. 1855(i)(1). The Magnuson-Stevens Fishery Conservation and Management...
Drayer, Sara M; Laufer, Larry R; Farrell, Maureen E
Autoimmune progesterone dermatitis is an uncommon disease presenting with cyclical skin eruptions corresponding with the menstrual cycle luteal phase. Because symptoms are precipitated by rising progesterone levels, treatment relies on hormone suppression. A 22-year-old nulligravid woman presented with symptoms mistaken for Stevens-Johnson syndrome. A cyclic recurrence of her symptoms was noted, and the diagnosis of autoimmune progesterone dermatitis was made by an intradermal progesterone challenge. After 48 months, she remained refractory to medical management and definitive surgical treatment with bilateral oophorectomy was performed. Autoimmune progesterone dermatitis is a challenging diagnosis owing to its rarity and variety of clinical presentations. Treatment centers on suppression of endogenous progesterone and avoidance of exogenous triggers. When these modalities fail, surgical management must be undertaken.
Ravin, Karen A; Rappaport, Lara D; Zuckerbraun, Noel S; Wadowsky, Robert M; Wald, Ellen R; Michaels, Marian M
Mycoplasma pneumoniae is a common cause of community-acquired respiratory illness in the adolescent population. Stevens-Johnson syndrome is an extrapulmonary manifestation that has been associated with M. pneumoniae infections. Three adolescent males presented within a 1-month period with M. pneumoniae respiratory illnesses and severe mucositis but without the classic rash typical of Stevens-Johnson. Diagnosis was facilitated by the use of a polymerase chain reaction-based assay. This case series highlights the potential for M. pneumoniae-associated Stevens-Johnson syndrome to occur without rash and supports the use of polymerase chain reaction for early diagnosis.
... Hung SI. Recent advances in the genetics and immunology of Stevens-Johnson syndrome and toxic epidermal necrosis. ... 2012 May 29. Citation on PubMed or Free article on PubMed Central More from Genetics Home Reference ...
Full Text Available Eeckhout, Bart and Edward Ragg, eds. Wallace Stevens Across the Atlantic (Basingstoke and New York: Palgrave Macmillan, 2008. Pp. xvii + 246. ISBN 978-0-230-53584-8.Bart Eeckhout and Edward Ragg’s edited collection of essays entitled Wallace Stevens Across the Atlantic is a diverse, well-informed and excellently conceptualized volume offering fresh insights into Wallace Stevens’ poetry. This book can serve as a good introduction to Wallace Stevens’ oeuvre for the general reader, university s...
Kim, M.J.; Lee, K.Y.
About one third of children with Stevens-Johnson syndrome have pulmonary involvement. As a consequence of airway epithelial injury, bronchiolitis obliterans can occur in these patients. Two cases of Stevens-Johnson syndrome-associated bronchiolitis obliterans in children were diagnosed and followed by high resolution CT without open lung biopsy. Serial changes of high resolution CT features of bronchiolitis obliterans are discussed and the literature is reviewed. (orig.)
Sri ram Anne
Full Text Available Toxic epidermal necrolysis (TEN and Stevens Johnson Syndrome (SJS are severe adverse cutaneous drug reactions that predominantly involve the skin and mucous membranes. They are characterized by mucocutaneous tenderness and typically hemorrhagic erosions, erythema and more or less severe epidermal detachment presenting as blisters and areas of denuded skin. Drugs are assumed or identified as the main cause of SJS/TEN in most cases, but Mycoplasma pneumoniae and Herpes simplex virus infections are well documented causes alongside rare cases in which the etiology remains unknown. Several drugs are at "high" risk of inducing TEN/SJS including: Allopurinol, Trimethoprim-sulfamethoxazole and other sulfonamide-antibiotics, aminopenicillins, cephalosporins, quinolones, carbamazepine, phenytoin, phenobarbital and NSAID's of the oxicam-type. Differential diagnosis includes linear IgA dermatosis and paraneoplastic pemphigus, pemphigus vulgaris and bullous pemphigoid, acute generalized exanthematous pustulosis (AGEP, disseminated fixed bullous drug eruption and staphyloccocal scalded skin syndrome (SSSS. Due to the high risk of mortality, management of patients with SJS/TEN requires rapid diagnosis, identification and interruption of the culprit drug, specialized supportive care ideally in an intensive care unit, and consideration of immunomodulating agents such as high-dose intravenous immunoglobulin therapy.
Yoshitake, Tadamasa; Nakamura, Katsumasa; Shioyama, Yoshiyuki
Erythema multiforme (EM) and Stevens-Johnson syndrome (SJS) are thought to be hypersensitivity syndromes with various causes, and radiotherapy might be one of the causes of these syndromes. We herein report two cases of EM/SJS following radiotherapy. The first case was a 63-year-old woman with breast cancer. At the end of postoperative radiotherapy with 60 Gy, severe pruritic erythema appeared in the irradiated area and spread over the whole body. She was diagnosed with EM by a skin biopsy. The second case was a 77-year-old woman with uterine cervical cancer who underwent postoperative radiotherapy. At a dose of 30.6 Gy, pruritic redness appeared in the irradiated area and the precordial region, and it became widespread rapidly with polymorphic transformation. Although without any histological confirmation, SJS was strongly suspected because of her pruritic conjunctivitis. Because both patients were given medicines during irradiation, radiotherapy may not be the only cause of EM/SJS. However, it should be noted that radiotherapy might trigger EM/SJS. (author)
Full Text Available Background and objectives: The genus Colchicum belongs to the family Colchicaceae, which comprises of 19 genera, and 225 species worldwide. They have been recognized for more than 2000 years for their noticeable biological properties. The Colchicum species are well known for presence of tropolonic alkaloids, mainly colchicine. Colchicine, is still the drug of choice for treatment of gout, and is used for the treatment of a number of proinflammatory disorders, such as familial Mediterranean fever, and Behcet’s disease. Clinical studies have proved colchicine to posses potent anti-tumor activity. Colchicum speciosum Steven is an indigenous perennial herbaceous plant widely distributed in northern, central and western regions of Iran. Methods: In the present study, the phytochemical composition of MeOH extract from bulbs of C. speciosum collected fromSavadkouh region, Iranwas investigated by combination of HPLC-PDA-MS spectrometry and NMR specroscopy. The fractionation of MeOH extract was carried out by partitioning on CH2Cl2, EtOAc and water. Results: The isolation and purification of CH2Cl2 portion by combination of reverse and normal phase chromatography resulted in the isolation, purification and identification of two new tropolonic alkaloids, compounds (1 and (2, as well as two known compound colchicine (3 and demecolcine (4. Their structures were established by extensive spectroscopic methods, including 1D (1H NMR and 2D-NMR (COSY, HSQC and HMBC. The absolute configurations of isolated compounds were established by aid of circular dichroism. Conclusion: Phytochemical investigation of CH2Cl2 extract of C. speciosum by combination of HPLC, column chromatography and hyphenated spectroscopic techniques led to identification two new alkaloids with potential as lead compounds.
French Lars E
Full Text Available Abstract Toxic epidermal necrolysis (TEN and Stevens Johnson Syndrome (SJS are severe adverse cutaneous drug reactions that predominantly involve the skin and mucous membranes. Both are rare, with TEN and SJS affecting approximately 1or 2/1,000,000 annually, and are considered medical emergencies as they are potentially fatal. They are characterized by mucocutaneous tenderness and typically hemorrhagic erosions, erythema and more or less severe epidermal detachment presenting as blisters and areas of denuded skin. Currently, TEN and SJS are considered to be two ends of a spectrum of severe epidermolytic adverse cutaneous drug reactions, differing only by their extent of skin detachment. Drugs are assumed or identified as the main cause of SJS/TEN in most cases, but Mycoplasma pneumoniae and Herpes simplex virus infections are well documented causes alongside rare cases in which the aetiology remains unknown. Several drugs are at "high" risk of inducing TEN/SJS including: Allopurinol, Trimethoprim-sulfamethoxazole and other sulfonamide-antibiotics, aminopenicillins, cephalosporins, quinolones, carbamazepine, phenytoin, phenobarbital and NSAID's of the oxicam-type. Genetic susceptibility to SJS and TEN is likely as exemplified by the strong association observed in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and SJS induced by carbamazepine. Diagnosis relies mainly on clinical signs together with the histological analysis of a skin biopsy showing typical full-thickness epidermal necrolysis due to extensive keratinocyte apoptosis. Differential diagnosis includes linear IgA dermatosis and paraneoplastic pemphigus, pemphigus vulgaris and bullous pemphigoid, acute generalized exanthematous pustulosis (AGEP, disseminated fixed bullous drug eruption and staphyloccocal scalded skin syndrome (SSSS. Due to the high risk of mortality, management of patients with SJS/TEN requires rapid diagnosis, evaluation of the prognosis
Martin, L; Hazouard, E; Michalak-Provost, S; Maurage, C; Machet, L
Acute bronchial mucosal sloughing related to Toxic Epidermal Necrolysis (Lyell syndrome) is widely reported in literature. On the contrary severe respiratory involvement is rare in post-infectious or toxic Epitheliolysis (Stevens-Johnson syndrome). There is no well-known predictive sign of bronchial epithelium involvement. An 18-year-old patient was admitted for Stevens-Johnson syndrome related to sulfasalazine (salazosulfapyridine). There were no respiratory signs. An acute respiratory failure occurred 36 hours after from admission due to an obstructive and desquamative necrosis of the tracheobronchial epithelium. We purpose that a fiberoptic laryngoscopy should be performed even in non-dyspneic patients suffering from Stevens-Johnson syndrome if hypersecretion is present. Fiberoptic bronchoscopy can be helpful in these cases.
... Number: 12-014. Applicant: California Institute of Technology, Pasadena, CA 91125. Instrument: Nova Nano... DEPARTMENT OF COMMERCE International Trade Administration Stevens Institute of Technology, et al... Constitution Avenue NW, Washington, DC Docket Number: 12-008. Applicant: Stevens Institute of Technology...
... Railway Service Corporation, Steven C. Hawkins and Cheryl R. Hawkins--Continuance in Control Exemption--Aiken Railway Company, LLC Western Carolina Railway Service Corporation (WCRS) and Steven C. Hawkins and Cheryl R. Hawkins (the Hawkins) (collectively, Applicants) have filed a verified notice of exemption...
Soheili, Arash; Tambar, Uttam K
A formal total synthesis of (±)-amathaspiramide F through a tandem palladium-catalyzed allylic amination/[2,3]-Stevens rearrangement is reported. The unexpected diastereoselectivity of the [2,3]-Stevens rearrangement was controlled by the substitution patterns of an aromatic ring. This discovery represents a new stereocontrolling element for [2,3]-sigmatropic rearrangements in complex molecular settings.
... for Sustainable Fisheries, Northeast Region, NMFS (Assistant Regional Administrator), has made a... University Cooperative Extension of Suffolk County, NY. Regulations under the Magnuson-Stevens Fishery... limits to conduct onboard sampling. This project proposes to evaluate bottom trawl modifications as a...
Owczarczyk-Saczonek, Agnieszka; Zdanowska, Natalia; Znajewska-Pander, Aleksandra; Placek, Waldemar
Etanercept and other anti-TNF-alpha agents have been indicated as a therapeutic option in severe drug reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis. Etanercept has been shown to quickly reduce the detachment of the epidermis and shorten healing time. Cases of etanercept-induced severe adverse drug reactions were also described. A 27-year-old woman with a 4-year history of etanercept and sulfasalazine treatment for rheumatoid arthritis was admitted with Stevens-Johnson syndrome. The patient received one dose of an OTC drug containing acetaminophen, phenylephrine and pheniramine two days prior to developing fist mucocutaneous symptoms. The most probable causative agent was paracetamol. Throughout the successful routine therapy of Stevens-Johnson syndrome etanercept therapy was continued. Sulfosalazin administration was stopped and administered again after recovery with no recurrence of the skin and mucosal symptoms. This case indicates that there is no justification for discontinuation of long-term anti-TNF-alpha treatment in patients who develop Stevens- Johnson syndrome / toxic epidermal necrolysis.
.... The pollock peer-reviewed benchmark stock assessment review (Stock Assessment Workshop, or SAW, 50... overfishing, rebuild overfished stocks, achieve optimum yield (OY), and minimize the economic impact of... Management Act (Magnuson-Stevens Act). This action would revise the biological reference points and stock...
... to estimate total haddock catch by the herring midwater trawl fleet in these herring management areas.... 110627355-1539-02] RIN 0648-BB08 Magnuson-Stevens Fishery Conservation and Management Act Provisions... the NE Multispecies Fishery Management Plan (FMP), which increases the haddock incidental catch cap...
... during the course of the FY. Management uncertainty for the LAGC IFQ fleet is considered very low because... incorporate ACT into the LAGC IFQ fleet allocation, but chose not to apply any management uncertainty buffer... Atmospheric Administration 50 CFR Part 648 Magnuson-Stevens Fishery Conservation and Management Act (MSA...
"Stevens v. Tillman" illustrates the limited reach of federal law in controversies where community activists use extreme, even illegal, methods to exert their will over objecting school officials. Defamation charges against activists for verbal abuses will apparently be very difficult to sustain, given court views that being called a…
Steven Hou, Ph.D., senior investigator in the Basic Research Laboratory at the Center for Cancer Research describes his latest research that has uncovered potential ways to eliminate cancer stem cells and may offer hope to patients with reoccurring tumors. Learn more...
An annotated facsimile of those pages of Alfred Russel Wallace’s notebook recording his consignments from the Malay Archipelago to his London agent, Samuel Stevens, is provided. Records of individual consignments are linked with the stages of Wallace’s and Charles Allen’s itineraries to which they
.../13monkeia.html . Copies of the small entity compliance guide are available at the following internet address... Procedure Act (APA). Pursuant to section 305(c)(3)(B) of the Magnuson-Stevens Act, management measures... APA. Comments and Responses Fifteen comments were received during the public comment period on the...
30. juunil üheaegselt Jaapanis ja USAs esilinastub Steven Spielbergi "Tehisintellekt" ("A.I. Artificial Intelligence"), mille kohta režissöör Tokyos pressikonverentsil väitis, et see on õieti Stanley Kubricku film, kuna põhineb temast järelejäänud 90-leheküljelisel ideeprojektil
... Massachusetts, Dartmouth, School for Marine Science and Technology. Regulations under the Magnuson-Stevens..., 978-281-9177. SUPPLEMENTARY INFORMATION: The University of Massachusetts, Dartmouth, School for Marine... preliminary determination that an exempted fishing permit application contains all of the required information...
... Massachusetts, Dartmouth, School for Marine Science and Technology. Regulations under the Magnuson-Stevens... preliminary determination that an exempted fishing permit application contains all of the required information....'' Fax: (978) 281-9135. FOR FURTHER INFORMATION CONTACT: Jason Berthiaume, Fishery Management Specialist...
Full Text Available Carbamazepine and other anticonvulsants are commoner cause of severe adverse cutaneous drug reactions such as erythema multiforme, toxic epidermal necrolysis (TEN, and Stevens-Johnson syndrome (SJS. We report a case of SJS rapidly progressing to TEN with a combination of haloperidol and carbamazepine in a patient with bipolar affective disorder. The pathophysiological mechanism underlying this reaction is discussed.
..., Dartmouth, School for Marine Science and Technology. Regulations under the Magnuson-Stevens Fishery.... SUPPLEMENTARY INFORMATION: The University of Massachusetts, Dartmouth, School for Marine Science and Technology... study and examining the influence of temperature. To facilitate compensation fishing in support of this...
Butchart, Ronald E.
Asserts that Steven Spielberg's film "Amistad" fictionalizes the overall facts of the case by inaccurately portraying many of the events that occurred. Explains that the myth-making tradition of Hollywood changes the messages derived from the Amistad court case. Critiques the teaching kit that corresponds to the movie. (CMK)
.... 111014628-3329-01] RIN 0648-BB54 Magnuson-Stevens Act Provisions; Implementation of the Shark Conservation... implement the provisions of the Shark Conservation Act of 2010 (SCA) and prohibit any person from removing any of the fins of a shark at sea, possessing shark fins on board a fishing vessel unless they are...
... Multispecies Fishery Management Plan which was approved on March 8, 2012. This action amends the Northeast Multispecies Fishery Management Plan to explicitly define and facilitate the effective operation of state.... 110901552-20494-02] RIN 0648-BB34 Magnuson-Stevens Fishery Conservation and Management Act Provisions...
Feinberg, Stephen; Totten, Samuel
Presents an interview with Steven Spielberg on his goals and methods for making "Schindler's List." Maintains that the important lessons of truth and tolerance will help prevent the Holocaust from happening again. Describes cooperative ventures with educational groups to develop instructional materials associated with the film. (CFR)
Full Text Available Objective: Monnose-Binding lectin (MBL appears to play an important role in the immune system. The genetic polymorphisms in the MBL2 gene can result in a reduction of serum levels, leading to a predisposition to recurrent infection. The aim of this study is to investigate the influence of a polymorphism in codon 54 of the MBL2 gene on the susceptibility to Erythema Multiforme, Stevens-Johnson Syndrome and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Syndrome (EM, SJS and SJS/TEN overlap syndrome. Material and Methods: Our study included 64 patients who were clinically and/or histopathologically diagnosed with EM, SJS, and SJS/TEN overlap syndrome and 66 healthy control subjects who were genotyped for the MBL2 gene codon 54 polymorphism using the PCR-RFLP method. For all statistical analyses, the level of significance was set at p<0.05. Results: The prevalence of the B allele was 18% in the EM, SJS and SJS/TEN patient groups and 13% in the control group. No significant differences in allele frequencies of any polymorphism were observed between the patient and control groups, although the B allele was more frequent in the patient groups (p=0.328.Conclusion: Our results provide no evidence of a relationship between MBL2 gene codon 54 polymorphism and the susceptibility to EM, SJS and SJS/TEN overlap syndrome. However, these findings should be confirmed in studies with a larger sample size.
Chu, Steven; Gates, Bill; Podesta, John
The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. This video captures a session called Fireside Chat that featured Steven Chu, the Secretary of Energy, and Bill Gates, Chairman of Microsoft Corporation. The session is moderated by John Podesta, Chair of the Center for American Progress. Energy Secretary Steven Chu and Microsoft Founder and Chairman Bill Gates exchanged ideas about how small businesses and innovators can overcome the challenges that face many startups.
Ferreira, M. R.; Amado, A.; Jorge, M.; Grillo, I. M.
Background: Stevens Johnson Syndrome and Erythema Multiforme are hypersensitivity skin reactions generally arising in the context of multiple causes. Radiation therapy is considered to be one of these causes, although most reports are hindered by concomitant medications. Aim: The aim of this paper was to present a case of Stevens Johnson Syndrome arising in a patient undergoing gynaecological brachytherapy with an unusual presentation. Case:We describe a case of a 56-year-old woman with endometrial cancer undergoing adjuvant gynaecological radiotherapy. While undergoing a gynaecological brachytherapy boost, she developed bilateral conjunctivitis that progressed to oral mucositis and pruritic erythema with sloughing of the skin on her arms and legs but not the torso or irradiated fields (namely the vaginal mucosa). Conclusion: This case illustrates the association of RT/SJS; however, it also raises the question of patients undergoing RT being more susceptible to SJS as opposed to a direct cause of the disease. (authors)
Full Text Available Minocycline is an antibiotic of tetracycline derivatives that is commonly used in the treatment of moderate to severe acne vulgaris. It has been reported to cause rare adverse events from mild cutaneous eruption to severe forms including drug-induced lupus, serum sickness-like reaction, and hypersensitivity reactions, etc. The risks of adverse events attributed to minocycline have not been ascertained reliably and there are concerns about the safety of minocycline which could possibly result in life-threatening events such as the Stevens-Johnson syndrome. Here we demonstrate an unusual case of Stevens-Johnson syndrome in conjunction with bilateral parotitis after the intake of minocycline in a Korean boy suggesting discreet use of the drug.
Chidester, S K; Vandersall, K S; Switzer, L L; Tarver, C M
Characterization of the reaction violence of LX-04 explosive (85% HMX and 15% Viton A by weight) was obtained from Steven Impact Tests performed above the reaction initiation threshold. A 155 mm Howitzer propellant driven gas gun was used to accelerate the Steven Test projectiles in the range of approximately 170-300 m/s to react (ignite) the LX-04 explosive. Blast overpressure gauges, acoustic microphones, and high-speed photography characterized the level of high explosive reaction violence. A detonation in this velocity range was not observed and when comparing these results (and the Susan test results) with that of other HMX based explosives, LX-04 has a more gradual reaction violence slope as the impact velocity increases. The high binder content (15%) of the LX-04 explosive is believed to be the key factor to the lower level of violence
Luisa María Pacheco Álvarez
Full Text Available El síndrome de Stevens-Johnson, es una enfermedad inflamatoria aguda, originada por una hipersensibilidad, que incluye la piel y las membranas mucosas; en una forma mayor pone en peligro la vida del paciente. Puede ser inducida por muchos factores precipitantes, desde los medicamentos hasta una infección. La afección se caracteriza por una súbita erupción morfológicamente variable, acompañada de estomatitis y oftalmia. En este trabajo se presenta un niño de 8 años de edad, con la entidad clínica en forma muy severa, el síndrome de Stevens-Johnson, que involucra manifestaciones cutáneas, oculares y de la mucosa oral, acompañada de otras complicaciones graves, por lo que requirió terapéutica en cuidados intensivos, y se logró una evolución satisfactoria del paciente.Stevens-Johnson syndrome is an acute inflammatory disease caused by a hypersensibility that includes the skin and the mucous membranes and that in a severe form endangers the patient’s life. It may be induced by many precipitating factors, from drugs to infection. The affection is characterized by a sudden morphologically variable rash, accompanied with stomatitis and ophthalmia. An 8-year-old boy suffering from this clinical entity in a very severe form, Stevens-Johnson syndrome, with skin , ocular and oral mucosa manifestations and with other serious complications, is presented in this paper. He had to be treated at the ICU and a satisfactory evolution was attained.
Gavigan, Geneviève M; Kanigsberg, Nordau D; Ramien, Michele L
We report a case of an 11-year-old female with Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) overlap, most likely triggered by sulfamethoxazole-trimethoprim, who was treated with the combination of methylprednisolone, cyclosporine, and etanercept. Her condition stabilized and her skin involvement did not progress after the addition of etanercept. To our knowledge, this is the first report of etanercept for pediatric SJS/TEN.
Full Text Available OBJECTIVE: To determine the conjunctival bacterial flora present in patients with Stevens-Johnson syndrome. METHODS: A prospective study of the conjunctival bacterial flora was performed in 41 eyes of 22 patients with Stevens-Johnson syndrome. The information gathered included the patient's sex and age, the duration of disease, the cause of Stevens-Johnson syndrome, and treatments. Scrapings of the inferior conjunctival fornix were performed in both eyes. Fourteen days before scraping, the patients were asked to interrupt all topical medication and start using 0.5% nonpreserved methylcellulose. The microbiological evaluation included microorganism identification and determination of antibiotic sensitivity. RESULTS: Of 22 patients (41 eyes, 14 (64% were females, and eight (36% were males. The mean age was 33.2 years, and the mean duration of disease was 15.6 years. Visual acuity ranged from light perception to 20/25 (1.57 logMar. The treatment received by most patients consisted of tear substitutes, topical antibiotics, and contact lenses. Bacterial identification was positive in 39 eyes (95% and negative in two eyes (5%. Gram-positive cocci accounted for 55.5% of the microorganisms, whereas gram-positive bacilli and gram-negative bacilli accounted for 19% and 25.5%, respectively. Half of the patients (54% had multiple bacterial species in their flora, and only one bacterial species was identified in the other half. Resistant bacteria were isolated from four eyes. The antibiotic sensitivity results for the Streptococcus group showed the lowest sensitivity and the highest microbial resistance identified. CONCLUSION: Patients with Stevens-Johnson syndrome have a diverse conjunctival flora that includes many pathogenic species.
Burkhart, Keith K.; Abernethy, Darrell; Jackson, David
Drug features that are associated with Stevens-Johnson syndrome (SJS) have not been fully characterized. A molecular target analysis of the drugs associated with SJS in the FDA Adverse Event Reporting System (FAERS) may contribute to mechanistic insights into SJS pathophysiology. The publicly available version of FAERS was analyzed to identify disproportionality among the molecular targets, metabolizing enzymes, and transporters for drugs associated with SJS. The FAERS in-house version was al...
Mazumdar, Goutameswar; Shome, Koushik
Metronidazole alone rarely causes Stevens-Johnson syndrome (SJS). We present a case of an elderly male patient who, following metronidazole use, developed neurological symptoms followed by pain and blisters on both soles, erythema of face and neck, scrotal itching and erosion, and hemorrhagic encrustation around the lips and oral mucous membrane. Initial neurological symptoms followed by mucocutaneous manifestation of SJS following metronidazole use is probably a new presentation of this case.
Al-Motowa, Saeed; Ahmad, Nauman; Khandekar, Rajiv; Zahoor, Abdul
To compare the efficacy of the olive tipped (OT) cannula to the conventional Steven's cannula for sub-Tenon block (STB) before cataract surgery. This prospective, randomized, double-masked compared STB delivered in cataract surgery patients with an OT cannula or a conventional Steven's cannula (ST). Outcome variables included the akinesia score and lid movement scores at 5 and 10 min. The patient perception of pain during delivery of the STB and surgery were also compared between groups. Surgeon satisfaction with anesthesia was compared between groups. P <0.05 was statistically significant. There were sixty patients in each group. The age between groups was not statistically different ( P = 0.4). The body mass index was higher in the ST group compared to the OT group ( P < 0.001). The akinesia score at 5 and 10 min did not differ between groups ( P = 0.07 and P = 0.6, respectively). The patient perception of pain during STB and surgery were similar between groups ( P = 0.1 and P = 0.06, respectively). There were six patients with mild chemosis and redness in the OT group and 15 patients in the ST group. An OT cannula is equally effective as the conventional Steven's cannula for delivering STB anesthesia before cataract surgery.
Norwich's Entropy Theory of Perception (1975-present) is a general theory of perception, based on Shannon's Information Theory. Among many bold claims, the Entropy Theory presents a truly astounding result: that Stevens' Law with an Index of 1, an empirical power relation of direct proportionality between perceived taste intensity and stimulus concentration, arises from theory alone. Norwich's theorizing starts with several extraordinary hypotheses. First, 'multiple, parallel receptor-neuron units' without collaterals 'carry essentially the same message to the brain', i.e. the rate-level curves are identical. Second, sensation is proportional to firing rate. Third, firing rate is proportional to the taste receptor's 'resolvable uncertainty'. Fourth, the 'resolvable uncertainty' is obtained from Shannon's Information Theory. Finally, 'resolvable uncertainty' also depends upon the microscopic thermodynamic density fluctuation of the tasted solute. Norwich proves that density fluctuation is density variance, which is proportional to solute concentration, all based on the theory of fluctuations in fluid composition from Tolman's classic physics text, 'The Principles of Statistical Mechanics'. Altogether, according to Norwich, perceived taste intensity is theoretically proportional to solute concentration. Such a universal rule for taste, one that is independent of solute identity, personal physiological differences, and psychophysical task, is truly remarkable and is well-deserving of scrutiny. Norwich's crucial step was the derivation of density variance. That step was meticulously reconstructed here. It transpires that the appropriate fluctuation is Tolman's mean-square fractional density fluctuation, not density variance as used by Norwich. Tolman's algebra yields a 'Stevens Index' of -1 rather than 1. As 'Stevens Index' empirically always exceeds zero, the Index of -1 suggests that it is risky to infer psychophysical laws of sensory response from information theory
Chong, Ian; Chao, Alice
One of the most dangerous dermatologic emergencies is Stevens-Johnson Syndrome (SJS)/toxic epidermal necrolysis (TEN). Although a rare disease, it can often lead to significant mortality. In this case report, we present a 77-year-old man who developed a sloughing rash that was secondary to a nonsteroidal anti-inflammatory drug. In addition to the recommended supportive care, the patient was treated with etanercept, a new, less commonly used intervention. We provide a brief review of SJS/TEN. Nonsteroidal anti-inflammatory drugs are a rare cause of SJS/TEN, and additionally, the use of biologics is a novel treatment modality for SJS/TEN.
Idar, D.J.; Lucht, R.A.; Straight, J.W. [and others
Low-velocity mechanical impact and subsequent high explosive (HE) reaction are of concern in credible accident scenarios involving the handling, transport, and storage of nuclear weapons. Using modified Steven spigot gun tests, the authors have investigated the high-explosive violent-reaction (HEVR) potential of PBX 9501 to low-amplitude insult. Reliable modeling predictions require that one identify the relevant parameters and behavioral responses that are key to the reaction mechanism(s) in PBX 9501. Additional efforts have been targeted at identifying relevant differences in the response between baseline and stockpile-aged PBX 9501 to low-velocity impacts.
Soheili, Arash; Tambar, Uttam K
We have developed a catalytic allylic amination involving tertiary aminoesters and allylcarbonates, which is the first example of the use of tertiary amines as intermolecular nucleophiles in metal-catalyzed allylic substitution chemistry. This process is employed in a tandem ammonium ylide generation/[2,3]-rearrangement reaction, which formally represents a palladium-catalyzed Stevens rearrangement. Low catalyst loadings and mild reaction conditions are compatible with an unprecedented substrate scope for the ammonium ylide functionality, and products are generated in high yields and diastereoselectivities. Mechanistic studies suggested the reversible formation of an ammonium intermediate.
Gupta, Lalit Kumar; Martin, Abhay Mani; Agarwal, Nidheesh; D'Souza, Paschal; Das, Sudip; Kumar, Rajesh; Pande, Sushil; Das, Nilay Kanti; Kumaresan, Muthuvel; Kumar, Piyush; Garg, Anubhav; Singh, Saurabh
Stevens-Johnson syndrome and toxic epidermal necrolysis are severe, life-threatening mucocutaneous adverse drug reactions with a high morbidity and mortality that require immediate medical care. The various immunomodulatory treatments include systemic corticosteroids, cyclosporine, intravenous immunoglobulin, cyclophosphamide, plasmapheresis and tumor necrosis factor-α inhibitors. The ideal therapy of Stevens-Johnson syndrome/toxic epidermal necrolysis still remains a matter of debate as there are only a limited number of studies of good quality comparing the usefulness of different specific treatments. The aim of this article is to comprehensively review the published medical literature and frame management guidelines suitable in the Indian perspective. The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL) assigned the task of preparing these guidelines to its special interest group on cutaneous adverse drug reactions. The group performed a comprehensive English language literature search for management options in Stevens-Johnson syndrome/toxic epidermal necrolysis across multiple databases (PubMed, EMBASE, MEDLINE and Cochrane) for keywords (alone and in combination) and MeSH items such as "guidelines," "Stevens-Johnson syndrome," "toxic epidermal necrolysis," "corticosteroids," "intravenous immunoglobulin," "cyclosporine" and "management." The available evidence was evaluated using the strength of recommendation taxonomy and graded using a three-point scale. A draft of clinical recommendations was developed on the best available evidence which was also scrutinized and critically evaluated by the IADVL Academy of Dermatology. Based on the inputs received, this final consensus statement was prepared. A total of 104 articles (meta-analyses, prospective and retrospective studies, reviews [including chapters in books], previous guidelines [including Indian guidelines of 2006] and case series) were critically evaluated and the evidence
Full Text Available Stevens-Johnson syndrome (SJS is an uncommon occurrence in Mycoplasma pneumoniae (M. pneumoniae infection (1–5% and has been mainly reported in children and young adults. We present a case of SJS in a 32-year-old male induced by M. pneumoniae infection. This patient presented with fever, cough, and massive occupation of mucus membranes with swelling, erythema, and necrosis accompanied by a generalized cutaneous rash. He clinically responded after treatment with antibiotics and IVIG. SJS is usually a drug-induced condition; however, M. pneumoniae is the commonest infectious cause and should be considered in the differential diagnosis.
Fernández Brizuela, Ener de Jesús; Morales Díaz, Felicia
Fundamento: el síndrome de Stevens-Johnson, también llamado eritema multiforme mayor, se caracteriza por una serie de lesiones cutáneas de diversa morfología, es una grave lesión en la cual están afectadas al menos dos membranas mucosas y la piel. La patogenia de esta enfermedad es desconocida aunque generalmente se considera que es provocada por una reacción de hipersensibilidad a drogas, infecciones y exposición a sustancias tóxicas. Caso clínico: esta afección fue diagnosticada en un niño ...
Graham, Laurie A; Finnigan, Gregory C; Kane, Patricia M
Tom Stevens' lab has explored the subunit composition and assembly of the yeast V-ATPase for more than 30 years. Early studies helped establish yeast as the predominant model system for study of V-ATPase proton pumps and led to the discovery of protein splicing of the V-ATPase catalytic subunit. The Vma - phenotype, characteristic of loss-of-V-ATPase activity in yeast was key in determining the enzyme's subunit composition via yeast genetics. V-ATPase subunit composition proved to be highly conserved among eukaryotes. Genetic screens for new vma mutants led to identification of a set of dedicated V-ATPase assembly factors and helped unravel the complex pathways for V-ATPase assembly. In later years, exploration of the evolutionary history of several V-ATPase subunits provided new information about the enzyme's structure and function. This review highlights V-ATPase work in the Stevens' lab between 1987 and 2017. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Full Text Available Resumen La necrólisis epidérmica tóxica y el síndrome de Stevens-Johnson son reacciones cutáneas adversas graves a medicamentos e infecciones. Los corticoides se describen como una alternativa terapéutica, sin embargo, su uso es aún controvertido. Utilizando la base de datos Epistemonikos, la cual es mantenida mediante búsquedas en múltiples bases de datos, identificamos cuatro revisiones sistemáticas que en conjunto incluyen once estudios primarios que responden la pregunta de interés. Extrajimos los datos y preparamos una tabla de resumen de los resultados utilizando el método GRADE. Concluimos que no está claro si los corticoides disminuyen la mortalidad o la estadía hospitalaria en la necrólisis epidérmica tóxica y el síndrome de Stevens-Johnson porque la certeza de la evidencia es muy baja.
Michael T. Catalano
Strogatz, Steven. The Joy of x: A Guided Tour of Math, from One to Infinity, (New York, NY, Houghton Mifflin Harcourt, 2012). 316 pp. ISBN 978-0-547-51765-0 The Joy of x: A Guided Tour of Math, from One to Infinity, by Steven Strogatz, is an engaging and example-filled argument for mathematics as a valuable and enjoyable activity. The thirty chapters are divided into six parts, entitled Numbers, Relationships, Shapes, Change, Data, and Frontiers. The discussion ranges from intuitive expl...
.... 111014628-3329-01] RIN 0648-BB54 Magnuson-Stevens Act Provisions; Implementation of the Shark Conservation.... SUMMARY: NMFS published a proposed rule on May 2, 2013, to implement provisions of the Shark Conservation Act of 2010 (SCA) that prohibit any person from removing any of the fins of a shark at sea, possessing...
.... 111014628-3329-01] RIN 0648-BB54 Magnuson-Stevens Act Provisions; Implementation of the Shark Conservation... period. SUMMARY: NMFS published a proposed rule on May 2, 2013, to implement provisions of the Shark Conservation Act of 2010 (SCA) that prohibit any person from removing any of the fins of a shark at sea...
Delattre, J.Y.; Safai, B.; Posner, J.B.
In 15 months we encountered eight patients with intracranial tumors who developed erythema multiforme (EM) or erythema multiforme bullosa (Stevens-Johnson syndrome). All occurred shortly after use of phenytoin (DPH) and brain radiation therapy (WBRT). The clinical picture differed from the classic form of EM in that the erythema began on the scalp and spread to the extremities, progressing in three cases to extensive bullous formation. There were no cases of EM among patients who received either DPH or radiotherapy alone. The combination of DPH, WBRT, and tapering of steroids seems to predispose to EM. The pathogenesis of the disorder is probably immunologic. In the absence of seizures, anticonvulsants should not be given routinely to patients with brain tumors. When anticonvulsants are necessary in patients scheduled for WBRT, DPH may not be the drug of choice
Khafaga, Y.M.; Jamshed, A.; Allam, A.A.K.; Ezzat, A.; Gray, A.J.; Schultz, H.; Mourad, W.A.; Al Eisa, A.
The use of phenytoin as a prophylactic anticonvulsant after brain surgery, particularly for brain tumors, is a common practice, regardless of whether the patient has a previous history of convulsions. This treatment policy assumes that the benefits exceed the risks. Four cases are described of adverse reactions of phenytoin during the cocomitant use of cranial radiotherapy. In one patient this proved fatal. There is increasing anecdotal support in the literature for a synergistic effect between phenytoin therapy and cranial radiotherapy that can result in the life-threatening Stevens-Johnson syndrome. While the association is uncommon, four cases within 24 months in one department suggest that the routine use of postoperative phenytoin as a prophylactic anticonvulsant in the absence of a history of seizures may not be warranted, particularly if the patient is to receive cranial radiotherapy. (orig.)
Musio, D.; Parisi, E.; Dionisi, F.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two of the most severe, rare, and life-threatening adverse reactions to medications. Their incidence is approximately two patients per million population per year. Several cases have been reported in the literature in which SJS and TEN have occurred in patients with a neoplasm undergoing radiation therapy and who are taking an anticonvulsant. We report a case of SJS-TEN that developed in a 51-year-old woman with nonresectable non-small-cell lung cancer during treatment with phenobarbital plus radiation therapy for bone metastases but in whom the irradiated areas did not exhibit the SJS skin reaction. To our knowledge, no similar cases have been reported in the literature. (author)
Carvalho, Evanilda Souza de Santana; Araújo, Edna Maria de; Santos, Silvone Santa Bárbara da Silva; Santos, Alexandro Gesner Gomes Dos
Objectives To analyze the representations of the nurse and individual in mental suffering portrayed in the photographic work by Steven Klein, in the USAnatomy exhibit held at the Museum of Sculpture (Museu da escultura) in São Paulo, in 2011. Methods Qualitative study carried out in 2012. Three photographs were submitted to iconographic analysis. The interpretation of the findings was based on theoretical frameworks of Foucault and Bourdieu on power relations. Results The nurse is represented as a sensual, insensitive person, with the power to control and torture while the person in psychological distress is represented as dirty, imprisoned and subjected to an asymmetrical relationship of power with the nurse. Final considerations Relationships of submission and symbolic dominance, in which the person in psychological distress has their body molded by discipline imposed by the nurse. Stereotypes of the image of the nurse oppose the ideology of the profession, which is to ensure the integrity of those being cared for.
Iyer, Geetha; Srinivasan, Bhaskar; Agarwal, Shweta; Kamala Muralidharan, Seema; Arumugam, Sumathi
Stevens Johnson Syndrome (SJS) can lead to end stage corneal blindness. This study describes the comprehensive treatment measures and their outcomes in the management of ocular sequelae and complications of SJS. Four hundred sixty-four eyes of 232 patients of SJS who underwent surgical intervention (punctal cautery, mucus membrane grafting for lid margin keratinisation, fornix reconstructive procedures, tectonic procedures, keratoplasty and keratoprosthesis) were studied. It was a non-comparative, retrospective, interventional case series. The primary outcome was the change in the best corrected visual acuity (BCVA). Secondary outcome measures included an improvement in the ocular surface status as indicated by corneal epithelial fluorescein staining and Schirmer's I strip wetting. The BCVA and the ocular surface status improved and/or stabilized in > 70 % of eyes following punctal cautery (n = 160) and > 80 % of eyes following lid margin mucus membrane grafting (n = 238). BCVA improved in 50 % of eyes following fornix reconstructive procedures (n = 24) with COMET (n = 6), in 63.9 % eyes with the Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) lens (n = 36), in 81.8 % of eyes after cataract surgery (n = 22). A BCVA of ≥20/200 was achieved in 72.34 % of eyes following keratoprostheses procedures (n = 47). The mean duration of follow up was 53.3 ± 15.2 months. The ocular sequelae of Stevens Johnson Syndrome can be blinding. They need to be identified and addressed early to retard the continued deterioration of the ocular surface. Our study aims to highlight the problem as well as the importance of comprehensive measures in the management of this potentially blinding disorder.
Forlini, Matteo; Adabache-Guel, Tania; Bratu, Adriana; Rossini, Paolo; Mingaine, Mpekethu Sam; Cavallini, Gian Maria; Forlini, Cesare
To report successful treatment of refractive glaucoma in a patient submitted to osteo-odonto-keratoprosthesis surgery for Stevens-Johnson syndrome. An interventional case report. The patient is a 62-year-old Indian man with known Stevens-Johnson syndrome since 1972 secondary to tetracycline therapy, with bilateral dry eye and corneal blindness. He underwent symblepharon release surgery with mucous membrane graft in both eyes. Osteo-odonto-keratoprosthesis surgery was later performed on the left eye. He was submitted to 2 Ahmed valve implants to control secondary glaucoma but visual fields continued to worsen; hence, he underwent endoscopic 140° cyclophotocoagulation with a good control of IOP. Endoscopic cyclophotocoagulation as alternative treatment provides good results in refractory glaucoma after osteo-odonto-keratoprosthesis surgery.
Rufini, Sara; Ciccacci, Cinzia; Politi, Cristina; Giardina, Emiliano; Novelli, Giuseppe; Borgiani, Paola
Stevens-Johnson syndrome and toxic epidermal necrolysis are severe, life-threatening drug reactions involving skin and membranes mucous, which are associated with significant morbidity and mortality and triggered, especially by drug exposure. Different studies have demonstrated that drug response is a multifactorial character and that the interindividual variability in this response depends on both environmental and genetic factors. The last ones have a relevant significance. In fact, the identification of new specific genetic markers involved in the response to drugs, will be of great utility to establish a more personalized therapeutic approach and to prevent the appearance of these adverse reactions. In this review, we summarize recent progresses in the Pharmacogenetics studies related to Stevens-Johnson syndrome/toxic epidermal necrolysis reporting the major genetic factors identified in the last years as associated with the disease and highlighting the use of some of these genomic variants in the clinical practice.
We describe the case history of a 9-year-old boy who developed Stevens-Johnson syndrome (SJS) following concomitant use of valproic acid and lamotrigine. He presented with rash and fever several weeks after introduction of lamotrigine, having been on valproic acid for seizure disorder. SJS happens to be one of the rare adverse reactions of antiepilepsy drugs (AED). Management is mainly supportive with care escalation when necessary because of the significant morbidity.
Bae, Hyun Min; Park, Yoo Jung; Kim, Young Hoon; Moon, Dong Eon
Stevens-Johnson syndrome (SJS) is a rare but life-threatening skin reaction disease and carbamazepine is one of its most common causes. We report a case of SJS secondary to carbamazepine in a patient with previous pruritus due to carbamazepine which was given for treatment of trigeminal neuralgia. We would like to caution all providers that carbamazepine readministration should be avoided in the patient with a previous history of SJS or adverse skin reaction. In addition, we strongly recommen...
Sc, Reddy; I, Tajunisah; T, Tan D
To report a successful osteo-odonto keratoprosthesis (OOKP) procedure in a case of end stage of corneal blindness due to Stevens-Johnson syndrome (SJS). An interventional case report. We describe a 35-year-old Indian woman, a known case of SJS with bilateral dry eyes and corneal blindness (failed corneal graft with vascularised total corneal opacity in the right eye and non-healing corneal ulcer in the left eye). Vision was hand movement only in both eyes. The corneal ulcer healed with medical treatment resulting in vascularised total corneal opacity with no improvement in vision. OOKP was performed in the right eye and the vision was improved from hand movement to 6/6. The same vision was maintained in the right eye at the last follow-up 5 years after surgery. OOKP provides good visual rehabilitation with long-term anatomically stable prosthesis in patients with end-stage of ocular surface disorders and corneal blindness secondary to SJS.
Nesburn, Anthony B; BenMohamed, Lbachir
Professor Steven L. Wechsler, a world-renowned eye researcher and virologist, passed away unexpectedly on June 12, 2016 at the age of 68. Many scientists came to know Professor Wechsler as a gifted researcher in the field of ocular Herpes Simplex Virus (HSV-1) latency, reactivation, and pathogenesis. Professor Wechsler published over 150 peer-reviewed scientific papers during his career, pushing forward the frontiers of his field eye research. His colleagues would say, 'Steve literally wrote the book on herpes latency and reactivation.' He was the first to show that the HSV-1 latency-associated transcript (LAT) is essential for the HSV-1 high spontaneous reactivation phenotype and that LAT has anti-apoptosis activity. This discovery of LAT's anti-apoptosis activity, which is a key factor in how the LAT gene enhances reactivation, was published in Science in 2000 and created a new paradigm that greatly increased understanding of HSV-1 latency and reactivation. In collaboration with Professor Lbachir BenMohamed, an immunologist, they later demonstrated that LAT also acts as an immune evasion gene. He was a caring scientist who truly enjoyed working and sharing his experience and expertise with young researchers. He will be remembered as a significant pillar within scientific and ocular herpes research communities worldwide. Professor Wechsler's dedication to science, his compassionate character, and wonderful sense of humor were exemplary. We, who were his friends and colleagues, will mourn his passing deeply.
Jayanta Kumar Das
Full Text Available An 18-year-old woman was referred with late sequelae of chloroquine-induced Steven-Johnson syndrome. At the time of presentation, the symblepharon was involving the upper lids to almost the whole of the cornea, and part of the lower bulbar conjunctiva with the lower lid bilaterally. Other ocular examinations were not possible due to the symblepharon. B-scan ultrasonography revealed acoustically clear vitreous, normal chorioretinal thickness, and normal optic nerve head, with an attached retina. Conjunctivo-corneal adhesion released by superficial lamellar dissection of the cornea. Ocular surface reconstruction was carried out with a buccal mucous membrane. A bandage contact lens was placed over the cornea followed by the symblepharon ring to prevent further adhesion. The mucosal graft was well taken up along with corneal re-epithelization. Best corrected visual acuity of 20/120 in both sides after 1 month and 20/80 after 3 months was achieved and maintained till the 2.5-year follow-up.
Full Text Available Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN are life-threatening disease. However, there are only few epidemiologic studies of SJS/TEN from China. To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case reports of patients with SJS/TEN from the China National Knowledge Infrastructure (CNKI and Wanfang database from 2006 to 2016 and patients with SJS/TEN who were admitted to the First Affiliated Hospital of Fujian Medical University during the same period. There were 166 patients enrolled, including 70 SJS, 2 SJS/TEN overlap, and 94 TEN. The most common offending drugs were antibiotics (29.5% and anticonvulsants (24.1%. Carbamazepine, allopurinol, and penicillins were the most common single offending drugs (17.5%, 9.6%, and 7.2%. Chinese patent medicines accounted for 5.4%. There were 76 (45.8% patients receiving systemic steroid and intravenous immunoglobulin (IVIG in combination therapy, especially for TEN (80.3%, and others were treated with systemic steroids alone. Mortality rate of combination treatment comparing with steroid alone in TEN patients had no statistical significance. In conclusion, carbamazepine and allopurinol were the leading causative drugs for SJS/TEN in China. Combination of IVIG and steroids is a common treatment for TEN, but its efficacy in improving mortality needs further investigation.
Full Text Available This article interprets the work of cultural theorists Steven Connor and Sianne Ngai in terms of their efforts to reevaluate certain key presumptions of aesthetic theory that inherits the surprisingly resilient biases of the 18th century, in particular the work of Immanuel Kant and Edmund Burke. Focusing on the work of Ngai and Connor, I think through the implications this recent theory has for the previously peripheral position occupied by gustatory taste and the cultural objects and experiences it implicates. I discuss the possibility that ideas and examples drawn from the work of Connor and Ngai might form the basis for an alternative area of analysis that is better adapted to the peculiarities of gustatory taste and the culinary. In particular, I argue that the visceral element, which tends to accompany gustatory taste, ought to be interpreted in terms of its generative contribution to the creation of concepts through metaphor, rather than as a muddying influence that prevents clarity of discrimination. Similarly, the close relationship between the edible and the domestic is deserving of a more generous reading than is commonly found in aesthetic theory underwritten by the categories of the sublime and the beautiful.
Full Text Available Stevens-Johnson syndrome (SJS and toxic epidermal necrolysis (TEN are life-threatening adverse reactions, which could be induced by a variety of drugs. It was proposed that human leukocyte antigen (HLA-restricted presentation of antigens (drugs or their metabolites to T lymphocytes initiates the immune reactions of SJS/ TEN. However, the genetic susceptibility and the exact pathogenesis were not clear until the recent studies. We first identified that HLA-B*1502 is strongly associated with carbamazepine (CBZ-induced SJS/TEN and HLA-B*5801 with allopurinol-SJS/TEN in Han Chinese. The same associations had been validated across different human populations. For the downstream danger signals, Fas-Fas ligand (FasL and perforin/granzyme B had been advocated as cytotoxic mediators for keratinocyte death in SJS/TEN. However, expression levels of these cytotoxic proteins from the skin lesions were too low to explain the distinct and extensive epidermal necrosis. Our recent study identified that the granulysin, a cytotoxic protein released from cytotoxic T cells or natural killer (NK cells, is a key mediator for disseminated keratinocyte death in SJS/TEN. This article aims to provide an overview of both of the genomic and immunologic perspectives of SJS/TEN. These studies give us a better understanding of the immune mechanisms, biomarkers for disease prevention and early diagnosis, as well as providing the therapeutic targets for the treatments of SJS/TEN.
Burkhart, Keith K; Abernethy, Darrell; Jackson, David
Drug features that are associated with Stevens-Johnson syndrome (SJS) have not been fully characterized. A molecular target analysis of the drugs associated with SJS in the FDA Adverse Event Reporting System (FAERS) may contribute to mechanistic insights into SJS pathophysiology. The publicly available version of FAERS was analyzed to identify disproportionality among the molecular targets, metabolizing enzymes, and transporters for drugs associated with SJS. The FAERS in-house version was also analyzed for an internal comparison of the drugs most highly associated with SJS. Cyclooxygenases 1 and 2, carbonic anhydrase 2, and sodium channel 2 alpha were identified as disproportionately associated with SJS. Cytochrome P450 (CYPs) 3A4 and 2C9 are disproportionately represented as metabolizing enzymes of the drugs associated with SJS adverse event reports. Multidrug resistance protein 1 (MRP-1), organic anion transporter 1 (OAT1), and PEPT2 were also identified and are highly associated with the transport of these drugs. A detailed review of the molecular targets identifies important roles for these targets in immune response. The association with CYP metabolizing enzymes suggests that reactive metabolites and oxidative stress may have a contributory role. Drug transporters may enhance intracellular tissue concentrations and also have vital physiologic roles that impact keratinocyte proliferation and survival. Data mining FAERS may be used to hypothesize mechanisms for adverse drug events by identifying molecular targets that are highly associated with drug-induced adverse events. The information gained may contribute to systems biology disease models.
Full Text Available In Steven Spielberg's cinema the flight is a recurring theme. Flying scenes can be sorted into two classes: those involving a realistic flight – by aircraft – and those involving a magical flight – by supernatural powers. The realistic flight is influenced by the war stories of Spielberg's father – a radio man in U.S. Air-force during WWII – and it is featured in such films as Empire of the Sun (1987, Always (1989, and 1941 (1979. The magical flight is influenced by James M. Barries' character Peter Pan (Peter and Wendy, 1911, which is quoted directly in E.T. the Extraterrestrial (1982 and, above all, in Hook (1991, which is a sequel to Barrie's story. These two types of flying scenes are analysed as to their meanings, compared to the models that influenced them, and surveyed as to their evolution across Spielberg's films. A central case study is the episode The Mission from Amazing Stories (1985, in which the realistic and the magical flights overlap.
Kiser, S.C.; Chenot, D.W.
Waste-water disposal is a major concern of the petroleum business, especially because of complications associated with many produced-water surface-impoundment percolation facilities. In the San Joaquin Valley, California, the current environmental regulations protecting the potentially usable groundwaters are stringent. the Stevens has significant potential as a disposal zone that may offer considerable capacity when the project is designed using proper geologic and engineering studies. The Stevens sands are well known for their oil-producing capabilities, however, not much has been published regarding its suitability as a zone for deep well injection. Conditions that make the Stevens potentially suitable include (1) adequate confinement providing geologic separation from the groundwater sources in the basin, (2) storage capacity, and (3) large areal extent. Because the search for acceptable disposal options is becoming critical, the current class II disposal options is becoming critical, the current class II disposal activities in the Stevens sands were reviewed and the areas offering the greatest future potential were identified. The authors then discuss class II disposal projects in Stevens sands in the West Bellevue and Midway Sunset oil fields and estimate the ultimate basin-wide disposal capacity of the Stevens
Full Text Available Background: Stevens - Johnson syndrome (SJS and Toxic Epidermal Necrolysis (TEN are currently regarded to be same disease entity which differs only in the extent and severity of epidermal sloughing. Both are potentially life-threatening mucocutaneous immunologic reaction, which are most frequently induced by drug consumption. The epithelial destruction of skin and mucosal membrane can cause both acute as well as chronic/ long term outcomes in term of late sequelae during the course of the disease. Sequelae often occur during the late phase of SJS/TEN and become a significant problem due its chronicity and severe degree of impairment, which leads to deterioration of quality of life for the patients. This may prevented or decreased in terms of intensity if the patient’s received prompt and sufficient topical therapy, particularly in managing lesions on the mucosa of the eye, oral, and genital. Objective : This review underlines topical therapies which could be delivered for management of mucocutaneous lesions from SJS/ TEN, aimed to prevent late sequelae due to SJS – TEN in order to improve the life quality of SJS – TEN survivors. Conclusion: SJS/ TEN frequently lead to late sequeale which includes skin, ocular, oral, and genital involvement. These sequelaes are often severe and chonic. Thus, may cause significant decrease in quality of life of SJS/TEN survivors. It is therefore most important to detect them early in order to manage them adequately. To date, we still have an impression that the specific sequelae of SJS – TEN are often late diagnosed and insufficiently treated. Finally, we want to emphasize that for mucosal involvement in particular, such as ocular, genital and oral involvement, a careful topical treatment have to be taken into special consideration in order to prevent severe late sequelae.
Basu, Sayan; Pillai, Vinay Sukumara; Sangwan, Virender S
To describe clinical outcomes of complications afflicting the autologous oral mucous membrane graft after modified osteo-odonto keratoprosthesis surgery in chronic Stevens-Johnson syndrome (SJS). Prospective case series. This study included 30 eyes of 30 patients with SJS-induced dry keratinized ocular surfaces; the patients underwent various stages of this procedure between August 2009 and February 2012. Mucosal complications were classified as either necrosis or overgrowth. Mucosal necrosis was managed according to a predesigned algorithm based on timing (pre- and postimplantation) and location (central or peripheral) of necrosis. Cases with mucosal overgrowth underwent mucosal debulking and trimming. Mucosal necrosis developed in 15 (50%) eyes and overgrowth in 4 (13.3%) eyes. Preimplantation necrosis (n = 7) was initially managed conservatively, but 2 eyes required free labial-mucous membrane grafting for persistent corneal exposure. Free labial-mucous membrane grafting was performed in all cases of postimplantation necrosis (n = 10), but 8 eyes required additional tarsal pedicle flaps (n = 6, for peripheral necrosis) or through-the-lid revisions (n = 2, for central necrosis). Debulking and trimming effectively managed all cases of mucosal overgrowth, but 3 eyes required repeat procedures. At 24.1 ± 6.5 months postimplantation, the keratoprosthesis was retained in all eyes, and the probability of maintaining 20/60 or better vision was similar in eyes with or without mucosal necrosis (86 ± 8.8% vs 80 ± 10.3%). Mucosal complications, especially necrosis, occurred commonly following modified osteo-odonto keratoprosthesis surgery in dry keratinized post-SJS eyes. The algorithm-based management approach described in this study was successful in treating these complications, retaining the prosthesis and preserving useful vision. Copyright © 2013 Elsevier Inc. All rights reserved.
Nizamoglu, M; Ward, J A; Frew, Q; Gerrish, H; Martin, N; Shaw, A; Barnes, D; Shelly, O; Philp, B; El-Muttardi, N; Dziewulski, P
Stevens Johnson Syndrome/toxic epidermal necrolysis (SJS/TEN) are rare, potentially fatal desquamative disorders characterised by large areas of partial thickness skin and mucosal loss. The degree of epidermal detachment that occurs has led to SJS/TEN being described as a burn-like condition. These patients benefit from judicious critical care, early debridement and meticulous wound care. This is best undertaken within a multidisciplinary setting led by clinicians experienced in the management of massive skin loss and its sequelae. In this study, we examined the clinical outcomes of SJS/TEN overlap & TEN patients managed by our regional burns service over a 12-year period. We present our treatment model for other burn centres treating SJS/TEN patients. A retrospective case review was performed for all patients with a clinical diagnosis of TEN or SJS/TEN overlap admitted to our paediatric and adult burns centre between June 2004 and December 2016. Patient demographics, percentage total body surface area (%TBSA), mucosal involvement, causation, severity of illness score (SCORTEN), length of stay and survival were appraised with appropriate statistical analysis performed using Graph Pad Prism 7.02 Software. During the study period, 42 patients (M26; F: 16) with TEN (n=32) and SJS/TEN overlap (n=10) were managed within our burns service. Mean %TBSA of cutaneous involvement was 57% (range 10-100%) and mean length of stay (LOS) was 27 days (range 1-144 days). We observed 4 deaths in our series compared to 16 predicted by SCORTEN giving a standardised mortality ratio (SMR) of 24%. Management in our burns service with an aggressive wound care protocol involving debridement of blistered epidermis and wound closure with synthetic and biological dressings seems to have produced benefits in mortality when compared to predicted outcomes. Copyright © 2017 Elsevier Ltd and ISBI. All rights reserved.
Macke, D.L.; Johnson, S.Y.; Otton, J.K.
Surficial accumulations of uranium (up to 0.2 wt. % U/sub 3/O/sub 8/, dry basis) are currently forming in organic-rich, poorly drained sediments deposited in fluvial-lacustrine environments. Known occurrences are in northeastern Washington, northern Idaho, the Sierra Nevada, the Colorado Front Range, New Hampshire, and several areas in Canada. The first accumulation of this type to be mined is in postglacial sediments of a 10-acre boggy meadow along North Flodelle Creek in Stevens County, Washington. The meadow is flanked by hills of fine- to medium-grained two-mica quartz monzonite that are mantled by glacial drift of late Wisconsin age (about 18,000 to 11,500 yr B.P.). Relatively thick, hummocky deposits of this same glacial drift impede drainage at the lower end of the meadow. Following ice retreat, glacial sediments on the meadow floor were reworked by fluvial processes, and patches of organic-rich sediment may have formed in ice-melt depressions. About 6700 yr B.P., a blanket of Mazama ash from the Crater Lake eruption was deposited in the meadow. Shortly thereafter, a beaver dam across the lower end of the meadow further restricted drainage, and peat and organic mud accumulated in the pond behind the dam. The dam is preserved in the stratigraphic record as a sheet-like body of woody peat (with beaver-gnawed sticks) about 100m wide and 60 cm thick. After the gradual influx of sand and coarse silt had filled the pond, and the beavers had abandoned the site, fluvial deposition was reestablished
Full Text Available OBJETIVO: Avaliar a qualidade de vida dos pacientes portadores de síndrome de Stevens-Johnson. MÉTODOS: Foram avaliados 14 pacientes com SSJ no período de 1998 e 1999 no Setor de Córnea do Departamento de Oftalmologia da UNIFESP. Empregou-se o questionário S. F. 36 - pesquisa em saúde. A pontuação indica melhor condição de saúde. A mesma avaliação foi repetida quatro vezes em intervalo de três meses. RESULTADOS: As médias das médias das 4 avaliações dos 14 pacientes apresentaram importante redução dos seus valores em todos os subitens do S.F. 36 (41,04±22,38 para aspectos físicos, 53,82±22,82 para aspectos sociais, 26,24±22,46 para aspectos emocionais, 34,95±25,45 para capacidade funcional, 42,03±31,85 para dor, 46,33±18,37 para vitalidade, 46,18±24,83 para saúde mental e 50,26±16,29 para saúde geral. CONCLUSÃO: O questionário S.F. 36 representa método adequado de avaliação de aspectos físicos e emocionais em pacientes com baixa de acuidade visual, que nos permitiu detectar comprometimento importante nas funções básicas dos pacientes com SSJ. Mais pacientes com maior tempo de seguimento são necessários para aprimorar a análise de qualidade de vida nesses pacientes e avaliar os efeitos do acompanhamento psicológico.
Full Text Available The Russian military largely went below the radar of Western interest after the disintegration of the Soviet Union. More than a decade after the creation of the Armed Forces of the Russian Federation, they have become again the object of interest for scholars – this time, both Western and Russian, as demonstrated by the reviewed volume, whose editors assembled a group of extraordinarily knowledgeable experts from Russia and the West. In his introduction, Steven Miller explains that the purp...
Nash, Aaron; Soheili, Arash; Tambar, Uttam K
Unnatural cyclic amino acids are valuable tools in biomedical research and drug discovery. A two-step stereoselective strategy for converting simple glycine-derived aminoesters into unnatural cyclic amino acid derivatives has been developed. The process includes a palladium-catalyzed tandem allylic amination/[2,3]-Stevens rearrangement followed by a ruthenium-catalyzed ring-closing metathesis. The [2,3]-rearrangement proceeds with high diastereoselectivity through an exo transition state. Oppolzer's chiral auxiliary was utilized to access an enantiopure cyclic amino acid by this approach, which will enable future biological applications.
Peppercorn, Amanda F.; Miller, Melissa B.; Fitzgerald, David; Weber, David J.; Groben, Pamela A.; Cairns, Bruce A.
The pathogenesis of Stevens Johnson Syndrome (SJS) remains obscure but it has been associated with various infectious agents, including members of the Herpes virus family. We present the first report of high level human herpesvirus-6 (HHV-6) viremia at the onset of SJS suggesting a possible new association. This finding supports the need for further investigation into the possible relationship between HHV-6 and SJS which may illuminate the pathogenesis of SJS and bring us closer to achieving enhanced prevention and treatment of this rare disease. PMID:20182379
The winners for 2011 of the Department of Energy's Ernest Orlando Lawrence Award were recognized in a ceremony held May 21, 2012. Dr. Steven Chu and others spoke of the importance of the accomplishments and the prestigious history of the award. The recipients of the Ernest Orlando Lawrence Award for 2011 are: Riccardo Betti (University of Rochester); Paul C. Canfield (Ames Laboratory); Mark B. Chadwick (Los Alamos National Laboratory); David E. Chavez (Los Alamos National Laboratory); Amit Goyal (Oak Ridge National Laboratory); Thomas P. Guilderson (Lawrence Livermore National Laboratory); Lois Curfman McInnes (Argonne National Laboratory); Bernard Matthew Poelker (Thomas Jeffereson National Accelerator Facility); and Barry F. Smith (Argonne National Laboratory).
Graham, Christopher F; Solter, Davor; Gearhart, John D; Nadeau, Joseph H; Knowles, Barbara B
In 2016, a symposium was convened in Leroy C. Stevens' honor, in association with a meeting of the International Stem Cell Initiative (ISCI). ISCI, funded internationally, is composed of a group of ~100 scientists from many countries, under the leadership of Peter Andrews, who have worked together to characterize a significant number of human pluripotent stem cell lines, to monitor their genetic stability and their differentiation into mature cell types and tissues in vitro and in vivo. Those at the ISCI meeting puzzled through one of the thorniest problems in the therapeutic use of the differentiated derivatives of pluripotent stem cells for human therapy; namely, pluripotent stem cells can differentiate into any cell type in the adult organism, but they also have the capacity for unlimited self-renewal, hence if mutated they may have tumorigenic potential. The meeting considered how these cells might become genetically or epigenetically abnormal and how the safety of these cells for human therapeutic uses could be assessed and assured. The symposium was an opportunity to pay tribute to Leroy Stevens and to the basic science origins of this newest aspect of regenerative medicine. It was a time to reflect on the past and on how it can influence the future of our field.
Michael T. Catalano
Full Text Available Strogatz, Steven. The Joy of x: A Guided Tour of Math, from One to Infinity, (New York, NY, Houghton Mifflin Harcourt, 2012. 316 pp. ISBN 978-0-547-51765-0 The Joy of x: A Guided Tour of Math, from One to Infinity, by Steven Strogatz, is an engaging and example-filled argument for mathematics as a valuable and enjoyable activity. The thirty chapters are divided into six parts, entitled Numbers, Relationships, Shapes, Change, Data, and Frontiers. The discussion ranges from intuitive explanations of basic concepts such as place value, the four arithmetic operations, percentage increase and decrease, and solving equations, to “higher” levels of mathematics such as calculus, probability and statistics, group theory, and the nature of infinity. As in John Allen Paulos’ work, Beyond Numeracy, the chapters are short and punchy, and they can be read independently. While the book is not specifically devoted to numeracy, several chapters, especially those in Part Five on Data, address ideas and examples relevant to quantitative literacy.
Dennis C Odion
Full Text Available In a recent PLOS ONE paper, we conducted an evidence-based analysis of current versus historical fire regimes and concluded that traditionally defined reference conditions of low-severity fire regimes for ponderosa pine (Pinus ponderosa and mixed-conifer forests were incomplete, missing considerable variability in forest structure and fire regimes. Stevens et al. (this issue agree that high-severity fire was a component of these forests, but disagree that one of the several sources of evidence, stand age from a large number of forest inventory and analysis (FIA plots across the western USA, support our findings that severe fire played more than a minor role ecologically in these forests. Here we highlight areas of agreement and disagreement about past fire, and analyze the methods Stevens et al. used to assess the FIA stand-age data. We found a major problem with a calculation they used to conclude that the FIA data were not useful for evaluating fire regimes. Their calculation, as well as a narrowing of the definition of high-severity fire from the one we used, leads to a large underestimate of conditions consistent with historical high-severity fire. The FIA stand age data do have limitations but they are consistent with other landscape-inference data sources in supporting a broader paradigm about historical variability of fire in ponderosa and mixed-conifer forests than had been traditionally recognized, as described in our previous PLOS paper.
Odion, Dennis C; Hanson, Chad T; Baker, William L; DellaSala, Dominick A; Williams, Mark A
In a recent PLOS ONE paper, we conducted an evidence-based analysis of current versus historical fire regimes and concluded that traditionally defined reference conditions of low-severity fire regimes for ponderosa pine (Pinus ponderosa) and mixed-conifer forests were incomplete, missing considerable variability in forest structure and fire regimes. Stevens et al. (this issue) agree that high-severity fire was a component of these forests, but disagree that one of the several sources of evidence, stand age from a large number of forest inventory and analysis (FIA) plots across the western USA, support our findings that severe fire played more than a minor role ecologically in these forests. Here we highlight areas of agreement and disagreement about past fire, and analyze the methods Stevens et al. used to assess the FIA stand-age data. We found a major problem with a calculation they used to conclude that the FIA data were not useful for evaluating fire regimes. Their calculation, as well as a narrowing of the definition of high-severity fire from the one we used, leads to a large underestimate of conditions consistent with historical high-severity fire. The FIA stand age data do have limitations but they are consistent with other landscape-inference data sources in supporting a broader paradigm about historical variability of fire in ponderosa and mixed-conifer forests than had been traditionally recognized, as described in our previous PLOS paper.
Capobianco, Amedeo; Caruso, Tonino; Palombi, Laura; Peluso, Andrea
Highlights: ► Mechanistic insights of the electro-induced Stevens rearrangement are provided. ► The reduction of PhCOCH 2 N + (CH 3 ) 2 CH 2 Ph is ascribed to a one-electron transfer process. ► An electrogenerated ammonium ylide has been detected by UV-spectroelectrochemistry. -- Abstract: The electrochemically-induced Stevens rearrangement of 2-(benzyldimethyl)ammonium acetophenone has been investigated by in situ UV–vis spectroelectrochemistry. Voltammetric analysis and absorption spectra recorded during the potentiostatic reduction indicate that the reaction proceeds via a one-electron transfer with a Platinum cathode and generation of an ammonium ylide intermediate
This paper reviews the history of the emergence of the molds and plastics industries in Portugal, finding that this history fits nicely with the accounts—originally proposed in Steven Klepper’s various works—of new industries emerging from older, related industries, and regional clusters emerging
Det här arbetet behandlar kreativ frihet och konstnärligt oberoende i filmskapande, utgående från begreppet independent film och regissörerna David Lynch, Jim Jarmusch och Steven Soderbergh. Den centrala frågeställningen är hur det har varit möjligt för en filmkonstnär att uppnå konstnärligt oberoende och samtidigt ha en långlivad och framgångsrik karriär. Arbetets fokus ligger på de tre regissörernas genombrottsfilmer; Eraserhead, Stranger Than Paradise och sex, lies, and videotape, och förs...
Coelho, Inês Dionísio
Trabalho final de mestrado integrado em Medicina (Dermatologia), apresentado à Faculdade de Medicina da Universidade de Coimbra. A Síndrome de Stevens-Johnson (SSJ) e a necrólise epidérmica tóxica (NET) são reacções mucocutâneas raras consideradas emergências médicas, podendo tornar-se fatais. Constituem dois extremos do mesmo espectro clínico das reacções cutâneas severas adversas a fármacos com necrose epidérmica, diferindo apenas na extensão do descolamento epidérmico. A gra...
Full Text Available Background and Aims: Stevens Johnson syndrome (SJS, toxic epidermal necrolysis (TEN and SJS-TEN overlap are serious adverse cutaneous drug reactions. Drugs are often implicated in these reactions. Methods: A retrospective analysis of inpatients′ data with these dermatological diagnoses were carried out for three years, to study the causative drugs, clinical outcome, and mortality in these conditions. Results: Thirty patients (15 TEN, nine SJS-TEN overlap, and six SJS were admitted. In 21 cases, multiple drugs were implicated whereas single drugs were responsible in nine. Anticonvulsants (35.08% were the most commonly implicated drugs followed by antibiotics (33.33% and NSAIDS (24.56%. Twenty-five patients recovered whereas five died (four TEN, one SJS-TEN overlap. Conclusion: Anticonvulsants, antibiotics and NSAIDs were the most frequently implicated drugs. TEN causes higher mortality than both SJS and SJS-TEN overlap.
Full Text Available Background: Stevens-Johnson Syndrome (SJS and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA-BFNx011502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-BFNx011502 is not a universal marker but is ethnicity-specific for Asians. Aim: To study the association between HLA-BFNx011502 and carbamazepine-induced SJS in Indian patients. Methods: Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers. Results: Out of eight patients studied for genotype, six patients were found to have the HLA-BFNx011502 allele. Conclusion: This study suggests an association between HLA-BFNx011502 and carbamazepine-induced SJS in Indian patients.
Jairo Antonio Melo Flórez
Aunque ya es una tesis bastante aceptada por los historiadores y sociólogos, la posibilidad de que, al contrario de la creencia popular, vivamos en tal vez una de las épocas más pacíficas de la historia es aún controvertida, más aún cuando llega un trabajo de una de las figuras públicas de la academia como es el profesor de Harvard Steven Pinker. Sin embargo, Pinker se había dedicado a psicología cognitiva y ganó fama al presentar al lenguaje como un instinto de la humanidad, y más aún al pre...
Jairo Antonio Melo Flórez
Full Text Available Aunque ya es una tesis bastante aceptada por los historiadores y sociólogos, la posibilidad de que, al contrario de la creencia popular, vivamos en tal vez una de las épocas más pacíficas de la historia es aún controvertida, más aún cuando llega un trabajo de una de las figuras públicas de la academia como es el profesor de Harvard Steven Pinker. Sin embargo, Pinker se había dedicado a psicología cognitiva y ganó fama al presentar al lenguaje como un instinto de la humanidad, y más aún al presentar sus resultados en libros dirigidos al público en general, algo bastante común entre los científicos norteamericanos.
Stevens measured the distribution, retention, and excretion of U-233 in seven beagles each given a single injection of U-233 citrate [2.8 μCi/kg U-233 (VI) (approx.3 mg/dog)]. These data, when plotted together with results obtained with the ICRP (Pub. 30) retention functions for purposes of comparison, are seen to differ only slightly from the ICRP-30 model. The number of transformations in the body, over a fifty-year period agree within a factor of 2. A three-compartment mammillary model has been parameterized from the data of Stevens by the method of Bernard. Retention in tissues of the body is represented by a linear combination of three compartments. The data plots for the dogs and ICRP-30 model will be presented and discussed together with the three compartment mammillary model for U-233 retention, distribution, and excretion. 3 figs., 2 tabs
Schneider, Jeremy A.; Cohen, Philip R.
Introduction Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two of the most severe dermatologic conditions occurring in the inpatient setting. There is a lack of consensus regarding appropriate management of SJS and TEN. Purpose The scientific literature pertaining to SJS and TEN (subsequently referred to as SJS/TEN) is summarized and assessed. In addition, an interventional approach for the clinician is provided. Methods PubMed was searched with the key words: cortic...
Pham, A J; Schilling, M W; Yoon, Y; Kamadia, V V; Marshall, D L
The objectives of this study were to characterize volatile compounds and to determine the characteristic aromas associated with impact compounds in 4 fish sauces using solid-phase micro-extraction, gas chromatography-mass spectrometry, Osme, and gas chromatography olfactometry (SPME-Osme-GCO) coupled with Stevens' Power Law. Compounds were separated using GCMS and GCO and were identified with the mass spectral database, aroma perceived at the sniffing port, retention indices, and verification of compounds by authentic standards in the GCMS and GCO. Aromas that were isolated and present in all 4 fish sauce samples at all concentrations included fishy (trimethylamine), pungent and dirty socks (combination of butanoic, pentanoic, hexanoic, and heptanoic acids), cooked rice and buttery popcorn (2,6-dimethyl pyrazine), and sweet and cotton candy (benzaldehyde). All fish sauces contained the same aromas as determined by GCO and GCMS (verified using authentic standard compounds), but the odor intensity associated with each compound or group of compounds was variable for different fish sauce samples. Stevens' Power Law exponents were also determined using this analytical technique, but exponents were not consistent for the same compounds that were found in all fish sauces. Stevens' Power Law exponents ranged from 0.14 to 0.37, 0.24 to 0.34, 0.09 to 0.21, and 0.10 to 0.35 for dirty socks, fishy, buttery popcorn, and sweet aromas, respectively. This demonstrates that there is variability in Stevens' Power Law exponents for odorants within fish sauce samples.
As I talked with Steven Spencer, Professor at the University of Waterloo and a groundbreaking researcher in the field of stereotype threat, I was impressed by his kind demeanor and effective speaking style. He shared information about his academic career, advice for graduate students as well as discussing this research on how to dismantle the negative stereotypes that inhibit women’s progression in science, technology, engineering, and math fields (STEM).
Mawson, Anthony R; Eriator, Ike; Karre, Sridhar
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are overlapping manifestations on a spectrum of acute drug-induced conditions associated with severe blistering, skin peeling, and multi-organ damage. TEN is an eruption resembling severe scalding, with ≥30% skin detachment. SJS is a mild form of TEN, characterized histologically by epidermal keratinocyte apoptosis with dermo-epidermal separation and extensive small blisters with <10% body surface skin detachment. The syndrome can be induced by numerous medications and typically occurs 1-4 weeks after the initiation of therapy. Granulysin is found in the lesions of patients with SJS/TEN and plays a significant pathogenic role in the condition, but the overall mechanisms linking medications, granulysin, and disease manifestations remain obscure. This paper reviews evidence suggesting that the different medications implicated in SJS/TEN have the common property of interacting and synergizing with endogenous retinoids (vitamin A and its congeners), in many instances causing the latter to accumulate in and damage the liver, the main storage organ for vitamin A. It is hypothesized that liver damage leads to the spillage of toxic retinoid compounds into the circulation, resulting in an endogenous form of hypervitaminosis A and cytotoxicity with widespread apoptosis, mediated by granulysin and recognized as SJS/TEN. Subject to testing, the model suggests that symptom worsening could be arrested at onset by lowering the concentration of circulating retinoids and/or granulysin via phlebotomy or plasmapheresis or by pharmacological measures to limit their expression.
Full Text Available Steven Spielberg’s 2005 film Munich tells the story of an Israeli counter-terrorist team in the aftermath of the hijacking and massacre at the Olympic Games in 1972. The film spawned broad discussion about its historical accuracy and its political standpoint. While criticism primarily focused on the historiographical representation of the actions depicted, this paper analyzes in two steps the genuinely filmic mode of historical representation ofMunich. First, the analysis discusses the interplay of two conflicting narrative strategies that negotiate the character development with the political struggle. And second, analysis focuses on the two formal devices at the core of the narrative conflict: The reflexive framing of television in the depiction of the Munich massacre as a traumatic media event and the excessive transformation of its memory in a series of flashbacks. Such elaboration of the narrative and formal strategies reveals the implicit historiographical structures of the film and suggests that the notion of ‘cultural trauma’ serves as the preferential—but problematic—template in telling the history of terrorism and violence.
Kohanim, Sahar; Palioura, Sotiria; Saeed, Hajirah N; Akpek, Esen K; Amescua, Guillermo; Basu, Sayan; Blomquist, Preston H; Bouchard, Charles S; Dart, John K; Gai, Xiaowu; Gomes, José A P; Gregory, Darren G; Iyer, Geetha; Jacobs, Deborah S; Johnson, Anthony J; Kinoshita, Shigeru; Mantagos, Iason S; Mehta, Jodhbir S; Perez, Victor L; Pflugfelder, Stephen C; Sangwan, Virender S; Sippel, Kimberly C; Sotozono, Chie; Srinivasan, Bhaskar; Tan, Donald T H; Tandon, Radhika; Tseng, Scheffer C G; Ueta, Mayumi; Chodosh, James
The intent of this review is to comprehensively appraise the state of the art with regard to Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with particular attention to the ocular surface complications and their management. SJS and TEN represent two ends of a spectrum of immune-mediated, dermatobullous disease, characterized in the acute phase by a febrile illness followed by skin and mucous membrane necrosis and detachment. The widespread keratinocyte death seen in SJS/TEN is rapid and irreversible, and even with early and aggressive intervention, morbidity is severe and mortality not uncommon. We have divided this review into two parts. Part I summarizes the epidemiology and immunopathogenesis of SJS/TEN and discusses systemic therapy and its possible benefits. We hope this review will help the ophthalmologist better understand the mechanisms of disease in SJS/TEN and enhance their care of patients with this complex and often debilitating disease. Part II (April 2016 issue) will focus on ophthalmic manifestations. Copyright © 2016 Elsevier Inc. All rights reserved.
Maritza Morales Solís
Full Text Available El síndrome de Stevens-Johnson (SSJ es una variante severa del eritema multiforme, consistente en una reacción de hipersensibilización que afecta piel y mucosa, además de otros órganos internos, y que se manifiesta con lesiones en zonas genitales, bucales y cutáneas, es idiopático en el 50% de los casos, generalmente producido por alergia a medicamentos. La muerte sobreviene en el 5-15% de los casos sin tratar. El riesgo de recurrencia es del 37% o más. Al Hospital Pediátrico Provincial Docente “Mártires de Las Tunas” fue traído un niño de seis años de edad, que tras el uso del Sulfaprín comenzó con lesiones que afectaban la piel y todas las mucosas, además de toma del estado general. Inmediatamente fue admitido en la Unidad de Cuidados Intensivos Pediátricos, donde fueron tomadas medidas que incluyeron supresión del agente causal, corticoterapia endovenosa, antibioticoterapia endovenosa, tratamiento de las lesiones, vigilancia del balance hidromineral y atención oftalmológica, respondiendo favorablemente. Se presenta el caso, por ser una enfermedad poco frecuente y de muy mal pronóstico.
On the one hand, the arts are particularly called for in this situation to fill the documentary gaps and silences through acts of experiment and imagination, and they may indeed have a redemptive effect by offering, in Hayden White’s terms, successful ‘emplotments’ of a traumatic past. One the other hand, this redemptive potential simultaneously poses a serious ethical challenge: As Theodor W. Adorno has warned with reference to the Holocaust, it is precisely by making ‘sense’ of human suffering, and by making accessible to the ‘senses’ what is utterly senseless and incomprehensible, that injustice may be done to the victims. In this paper, I will try to illustrate this problematic by looking at two recent films that have attempted to represent the horrors of the middle passage – Steven Spielberg’s canonical Amistad (a terrible failure, in my view, and Guy Deslauriers’ film The Middle Passage [Passage du Milieu]. Based on a script by the Martiniquean novelist and poet Patrick Chamoiseau, the latter example uses an aesthetic approach which may point at a way out of the dilemma outlined above.
Monteiro, Diana; Egipto, Paula; Barbosa, Julia; Horta, Ricardo; Amarante, Jose; Silva, Pedro; Silva, Alvaro
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) corresponds to a rare and acute life-threatening mucocutaneous reactions characterized by extensive necrosis and epidermal detachment. There are no efficacious pharmaceutical interventions proven through large clinical trials. We sought to study clinical cases admitted in our institution in order to determine which drugs and medical comorbidities or treatments impacted the mortality. In a retrospective study over 9 years we evaluated all patients presenting biopsy-proven SJS or TEN for age, gender, total body surface area involved, causing agents, SCORTEN score, blood transfusion, steroid administration, intubation, length of intensive care stay and death rate. Statistical analysis was done using SPSS statistical software. The highest incidence of SJS and TEN was in age group of 71-80 years. Of the 30 patients, 30% died from SJS/TEN, mainly due sepsis. For each subgroup SJS/TEN overlap had the highest mortality. The highest mortality was from antibiotic treatment as causing agent. Step-wise regression analysis identified mechanical ventilation requirement and age over 65 years as mortality high-risk factors. The most crucial interventions are discontinuation of the offending drug and prompt referral to a burn unit, which helps in early diagnosis and decrease mortality in these diseases. When SJS/TEN is caused by antibiotics suspicion of developing fatal sepsis should be high, independently of patients' medical condition.
Özel Halil Barış
Full Text Available Frost-resistance variability of Scotch pine (Pinus sylvestris L. var. hamata Steven seedlings grown in nurseries conditions, originated from 10 provenances, have been analyzed. The provenances from Black Sea region, Central Anatolian region and Eastern Anatolian region in Turkey have been used in selection of seed zones. The results of frost-resistance tests indicated a strong relationship of implemented freezing degrees with injury degrees of Scotch pine needles and photosynthetic productivities. On the other hand, another significant relationship has been determined between chlorophyll fluorescence and ion leakage methods (r=-0.801. This result shows that those two methods can be safely used in determining the damages due to low temperatures. In frost resistance tests, Scotch pine seedlings from different provenances have been frozen at -10, -20, -30 and -40°C. According to the Duncan test results, it has been determined that damage increased as temperature decreased. The damage level at -10°C implementation is 3.5% which can be tolerated by plants. But when the temperature has been decreased to -20°C, the level of damage has increased to 51.25%. As a result of photosynthetic analyses in this phase, it has been determined that there is a statistically significant relationship between provenances and temperature levels. Under the light of those findings, they have determined that the photosynthetic productivity has significantly decreased at temperatures between -20°C and -40°C. This situation conforms to injury index values determined in this study. As a result of injury index and photosynthetic productivity tests used for determining the damage after frost-resistance tests, it has been determined that the provenances of Amasya-Kunduz, Bolu-Aladağ, Düzce-Yığılca, Samsun-Vezirköprü and Eskişehir-Çatacık are more sensitive to frost than other provenances.
Katherine J. Sullivan
Full Text Available Stevens-Johnson syndrome (SJS, toxic epidermal necrolysis (TEN, and overlap syndrome (SJS-TEN are rare, serious skin and mucosa break-down conditions frequently associated with antibiotic use. The role of nonprescription medications alone, or in combination with antibiotics in triggering SJS/TEN, is largely unknown. This study summarized data collected from patient surveys about nonprescription and antibiotic use prior to a SJS/TEN diagnosis. The survey was administered online to members of the U.S. SJS Foundation who had been diagnosed with SJS/TEN or were the parent of a child who had been diagnosed with SJS/TEN. Respondents were asked about nonprescription medications taken within the year before diagnosis, and the approximate point in time before diagnosis that they had taken them. They were also asked about specific prescription medications, including antibiotics, that they took before diagnosis. An estimated 4500 patients received an invitation to complete the survey. 251 patients completed it, resulting in a response rate of 5.6%. The mean age of respondents was 43 years (SD (standard deviation = 17.3 and 70% were female. 32.3% of respondents indicated that a prescription antibiotic triggered their reaction. 14.1% indicated a nonprescription medication had triggered their SJS/TEN, and 18.1% said a nonprescription medication may have triggered their SJS/TEN. 85.5% of respondents said they took a nonprescription medication within three months of their SJS/TEN diagnosis. Of those respondents who reported that an antibiotic triggered their SJS/TEN, 35.2% reported taking a nonprescription medication within the three months prior to their diagnosis. This survey captured valuable information about nonprescription and antibiotic use in SJS/TEN patients. It is important for future studies to estimate the impact of antibiotics on SJS/TEN, and account for nonprescription medication use in that relationship.
Ana Paula Sakamoto
Full Text Available Objective: To assess Stevens-Johnson syndrome (SJS and toxic epidermal necrolysis (TEN in a large population of childhood-onset systemic lupus erythematosus (cSLE patients. Methods: Multicenter study including 852 cSLE patients followed in Pediatric Rheumatology centers in São Paulo, Brazil. SJS was defined as epidermal detachment below 10% of body surface area (BSA, overlap SJS-TEN 10-30% and TEN greater than 30% of BSA. Results: SJS and TEN was observed in 5/852 (0.6% cSLE female patients, three patients were classified as SJS and two patients were classified as overlap SJS-TEN; TEN was not observed. The mean duration of SJS and overlap SJS-TEN was 15 days (range 7-22 and antibiotics induced four cases. Regarding extra-cutaneous manifestations, hepatomegaly was observed in two cSLE patients, nephritis in two and neuropsychiatric involvement and conjunctivitis were observed respectively in one patient. Hematological involvement included lymphopenia in four, leucopenia in three and thrombocytopenia in two patients. The mean SLEDAI-2K score was 14.8 (range 6-30. Laboratory analysis showed low C3, C4 and/or CH50 in two patients and the presence of anti-dsDNA autoantibody in two patients. One patient had lupus anticoagulant and another one had anticardiolipin IgG. All patients were treated with steroids and four needed additional treatment such as intravenous immunoglobulin in two patients, hydroxychloroquine and azathioprine in two and intravenous cyclophosphamide in one patient. Sepsis was observed in three cSLE patients. Two patients required intensive care and death was observed in one patient. Conclusion: Our study identified SJS and overlap SJS-TEN as rare manifestations of active cSLE associated with severe multisystemic disease, with potentially lethal outcome.
Küsimusele vastavad hariduskolleegiumi algkooli 3. klassi õpilane Egert, prantsuse lütseumi 12. klassi õpilane Triinu Lepp, Sillamäe kutsekooli 3. kursuse õpilane Gleb Tšurbanov, Tallinna reaalkooli 11. klassi õpilane Erik Paemurru, Toronto Crescenti keskkooli õpilane Steven Huang, kunstiakadeemia muinsuskaitse- ja restaureerimisosakonna õppejõud Jaan Tamm, Tartu Miina Härma gümnaasiumi 2. a klassi õpilane Erki Külaots, Tallinna 21. kooli 11. klassi õpilane Sander Kaur ja Tapa gümnaasiumi 7. klassi õpilane Evelin Orgse
Susheera Chatproedprai; Vanvara Wutticharoenwong; Therdpong Tempark; Siriwan Wananukul
Aim. To determine the probable causative factors, clinical features, and treatment outcomes of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS-TEN overlap in children. Methods. A 20-year database review of all children diagnosed with SJS/TEN/SJS-TEN overlap at the King Chulalongkorn Memorial Hospital, Thailand. Results. 36 patients (M : F, 16 : 20) with the mean age of 9.2±4.0 years were identified. There were 20 cases of SJS, 4 cases of SJS-TEN overlap, and 12 cases...
Arafat, Samer N.; Suelves, Ana M.; Spurr-Michaud, Sandra; Chodosh, James; Foster, C. Stephen; Dohlman, Claes H.; Gipson, Ilene K.
Objective To investigate the levels of matrix metalloproteinases (MMPs), myeloperoxidase (MPO) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in tears of patients with Stevens-Johnson syndrome (SJS) and ocular cicatricial pemphigoid (OCP). Design Prospective non-interventional cohort study. Participants Four SJS patients (7 eyes), 19 OCP patients (37 eyes) and 20 post-phacoemulsification healthy controls (40 eyes). Methods Tear washes were collected from all patients and were analyzed for levels of MMP-2, -3, -7, -8, -9, -12, MPO and TIMP-1 using multi-analyte bead-based enzyme-linked immunosorbent assays (ELISA). Total MMP activity was determined using a fluorimetric assay. Correlation studies were performed between the various analytes within study groups. Main Outcome Measures Levels of MMP-2, -3, -7, -8, -9, -12, MPO and TIMP-1 (in ng/µg protein), total MMP activity (in relative fluorescent units/min/µg protein) in tears, MMP-8/TIMP-1, MMP-9/TIMP-1 ratios and the correlations between MMP-8 and MMP-9 and each MMP and MPO. Results MMP-8, MMP-9 and MPO levels were significantly elevated in SJS and OCP tears (SJS > OCP) when compared to controls. MMP activity was highest in SJS while OCP and controls showed lower and similar activities. TIMP-1 levels were decreased in SJS and OCP when compared to controls with OCP levels reaching significance. MMP-8/TIMP-1 and MMP-9/TIMP-1 ratios were markedly elevated in SJS and OCP tears (SJS > OCP) when compared to controls. Across all study groups, MMP-9 levels correlated strongly with MMP-8 and MPO levels and MMP-8 correlated with MPO but did not reach significance in SJS. There was no relationship between MMP-7 and MPO. Conclusions Since MMP-8 and MPO are produced by inflammatory cells, particularly neutrophils, the correlation data indicate that they may be the common source of elevated enzymes including MMP-9 in SJS and OCP tears. Elevated MMP/TIMP ratios and MMP activity suggest an imbalance in tear MMP regulation
Arafat, Samer N; Suelves, Ana M; Spurr-Michaud, Sandra; Chodosh, James; Foster, C Stephen; Dohlman, Claes H; Gipson, Ilene K
To investigate the levels of matrix metalloproteinases (MMPs), myeloperoxidase (MPO), and tissue inhibitor of metalloproteinase-1 (TIMP-1) in tears of patients with Stevens-Johnson syndrome (SJS) and ocular cicatricial pemphigoid (OCP). Prospective, noninterventional cohort study. Four SJS patients (7 eyes), 19 OCP patients (37 eyes), and 20 healthy controls who underwent phacoemulsification (40 eyes). Tear washes were collected from all patients and were analyzed for levels of MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MPO, and TIMP-1 using multianalyte bead-based enzyme-linked immunosorbent assays. Total MMP activity was determined using a fluorometric assay. Correlation studies were performed between the various analytes within study groups. Levels of MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MPO, and TIMP-1 (in nanograms per microgram of protein) and total MMP activity (in relative fluorescent units per minute per microgram of protein) in tears; MMP-8-to-TIMP-1 ratio; MMP-9-to-TIMP-1 ratio; and the correlations between MMP-8 and MMP-9 and both MMP and MPO. MMP-8, MMP-9, and MPO levels were elevated significantly in SJS and OCP tears (SJS>OCP) when compared with controls. The MMP activity was highest in SJS patients, whereas OCP patients and controls showed lower and similar activities. The TIMP-1 levels were decreased in SJS and OCP patients when compared with those in controls, with levels in OCP patients reaching significance. The MMP-8-to-TIMP-1 and MMP-9-to-TIMP-1 ratios were markedly elevated in SJS and OCP tears (SJS>OCP) when compared with those of controls. Across all study groups, MMP-9 levels correlated strongly with MMP-8 and MPO levels, and MMP-8 correlated with MPO, but it did not reach significance in SJS patients. There was no relationship between MMP-7 and MPO. Because MMP-8 and MPO are produced by inflammatory cells, particularly neutrophils, the correlation data indicate that they may be the common source of elevated enzymes, including MMP-9
Full Text Available Amanda J Laska,1 Marie J Han,1 Josh A Lospinoso,2 Patrick J Brown,1 Thomas M Beachkofsky1 1Department of Dermatology, San Antonio Uniformed Services Health Education Consortium, San Antonio, TX, 2780th Military Intelligence Brigade, Ft Meade, MD, USA Purpose: Genetic polymorphisms have been linked to an increased predisposition to developing certain diseases. For example, patients of Han-Chinese descent carrying the HLA-B*1502 allele are at an increased risk of developing Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN if given carbamazepine. Given the complexity of in vivo drug metabolism, it is plausible that the activity of enzyme systems unrelated to specific drug metabolism may be important. Although multiple biomarkers have been identified in unique ethnic groups, there has yet to be a study investigating the presence of the slow metabolizing allele of CYP2C19, denoted CYP2C19*2, in diverse groups and the risk of developing SJS/TEN. Patients and methods: This study looked into the carrier status of CYP2C19*2, a poor metabolizing variant of CYP2C19, in patients diagnosed with SJS/TEN. We looked at its status in our series as a whole and when patients were divided by ethnicity. Genomic DNA was extracted from formalin-fixed paraffin-embedded tissue of patients with biopsy-proven SJS/TEN and real-time polymerase chain reaction was used to assess for the presence of CYP2C19*2. Results: CYP2C19*2 status was determined in 47 patients. Twenty-nine of these 47 patients had a single medication implicated as causing their disease, and eight of these patients were heterozygous or homozygous for CYP2C19*2. There was insufficient evidence to conclude that the presence of CYP2C19*2 is an independent predictor of risk for developing SJS/TEN in our series as a whole. This analysis also confirmed that the frequency of the CYP2C19*2 polymorphism within the different ethnicities in our series did not vary statistically from reported ethnic
Full Text Available Stevens-Johnson syndrome (SJS and toxic epidermal necrolysis (TEN form a spectrum of a rare and life-threatening cutaneous drug reaction. SJS/TEN in pregnancy poses largely unknown risk factors and outcomes for both the mother and foetus compared to the general population.We conducted a study of consecutive pregnant women admitted to single tertiary referral centre in South Africa with SJS/TEN over a 3 year period. They were all managed by the same medical team using the same protocols. We evaluated their underlying illnesses, offending drugs and the course of pregnancy and outcomes to determine factors influencing maternal and foetal outcomes.We identified twenty-two women who developed SJS/TEN while pregnant, all of them HIV-infected. Their median age was 29 years. The majority 16/22 (73% had SJS, the milder variant of the disease affecting < 10% body surface area. Nevirapine was the offending drug in 21/22 (95% cases. All 22 of the mothers survived with 3/22 (14% developing postpartum sepsis. Pregnancy outcomes were known in 18/22 women and 9/18 (50% babies were delivered by caesarean section. There were 2 foetal deaths at 21 and 31 weeks respectively and both were associated with post-partum sepsis. Postnatal complications occurred in 5 cases, 3 involving the respiratory system and the other two being low birth weight deliveries. Eight placentae and one foetus were sent for histology and none showed macroscopic or microscopic features of SJS/TEN. On follow-up, only 12/20 children were tested for HIV at 6 weeks post-delivery and none of them were HIV-infected. All had received prophylactic ARVs including nevirapine.TEN, the severe form of the disease, was associated with poorer foetal outcomes. SJS/TEN-associated mortality is not increased in HIV-infected pregnant women. Maternal SJS/TEN does not seem to commonly manifest in the foetus.
Duty Free Shoppersi asutaja Chuck Feeney on oma sihtasutusega Atlantic Philanthropies 30 aasta jooksul annetanud juba üle 6 miljardi dollari toetades erinevaid meditsiini, haridust ning päästeprojekte kogu maailmas, tehes seejuures kõik, et tema isik avalikuks ei tuleks
The Fermi Award is a Presidential award and is one of the oldest and most prestigious science and technology honors bestowed by the U.S. Government. On May 7, 2012 it was conferred upon two exceptional scientists: Dr. Mildred Dresselhaus, 'for her scientific leadership, her major contributions to science and energy policy, her selfless work in science education and the advancement of diversity in the scientific workplace, and her highly original and impactful research,' and Dr. Burton Richter, 'for the breadth of his influence in the multiple disciplines of accelerator physics and particle physics, his profound scientific discoveries, his visionary leadership as SLAC Director, his leadership of science, and his notable contributions in energy and public policy.' Dr. John Holder, Director of the White House Office of Science and Technology Policy, opened the ceremony, and Dr. Bill Brinkman, Director of DOE's Office of Science introduced the main speaker, Dr. Steven Chu, U.S. Energy Secretary.
Ways of Narrating Memory: Hannah Arendt’s "Eichmann in Jerusalem" and Steven Spielberg’s "Schindler’s List" / Formas de narração da memória: “Eichmann em Israel”, de Hannah Arendt e “A Lista de Schindler”, de Steven Spielberg
Full Text Available Abstract It is self-evident that events of the past are bound to places and acting people, they are playing a decisive role for memory and history. Meaning and importance of places and actions in the past depend on their contexts and each change inevitably also changes the meaning of the events itself. I would like to demonstrate some of the consequences of such a change by comparing Hannah Arendt’s “Eichmann in Jerusalem“ with Steven Spielberg’s “Schindler’s List“ who decontextualized a factual story and thus changed places and acting people. But before doing this, I would like to emphasize the importance which places and acting people play for memory and history with some perhaps unusual remarks. They refer to the official European history and politics which seem to be marked by the absence of places and acting people.Keywords: Eichmann in Jerusalem, Hannah Arendt, Schindler’s List, Steven SpielbergResumo É autoevidente que acontecimentos do passado estão condicionados a lugares e a pessoas atuantes, que têm papel fundamental na memória e na história. O significado e a importância de lugares e de ações do passado dependem de seu contexto e cada mudança sua inevitavelmente altera também os próprios acontecimentos. Eu gostaria de demonstrar algumas das consequências de tal mudança comparando “Eichmann em Israel”, de Hannah Arendt com “A Lista de Schindler”, de Steven Spielberg, que descontextualizou uma história real e, assim, modificou lugares e pessoas de atuação. Mas antes disso, eu gostaria de enfatizar a importância que lugares e pessoas atuantes têm a memória e na história com alguns comentários talvez inusitados. Eles fazem referência à História oficial e à política da Europa que parecem ser marcados pela ausência de lugares e de pessoas de atuação marcante.Palavras-chaves: Eichmann em Israel, Hannah Arendt, Lista de Schindler, Steven Spielberg
Schneider, Jeremy A; Cohen, Philip R
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two of the most severe dermatologic conditions occurring in the inpatient setting. There is a lack of consensus regarding appropriate management of SJS and TEN. The scientific literature pertaining to SJS and TEN (subsequently referred to as SJS/TEN) is summarized and assessed. In addition, an interventional approach for the clinician is provided. PubMed was searched with the key words: corticosteroids, cyclosporine, etanercept, intravenous immunoglobulin, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The papers generated by the search, and their references, were reviewed. Supportive care is the most universally accepted intervention for SJS/TEN. Specific guidelines differ from the care required for patients with thermal burns. Adjuvant therapies are utilized in most severe cases, but the data are thus far underwhelming and underpowered. Using systemic corticosteroids as sole therapy is not supported. A consensus regarding combined corticosteroids and intravenous immunoglobulin (IVIG) has not been reached. Data regarding IVIG, currently the standard of care for most referral centers, is conflicting. Newer studies regarding cyclosporine and tumor necrosis factor inhibitors are promising, but not powered to provide definitive evidence of efficacy. Data regarding plasmapheresis is equivocal. Thalidomide increases mortality. Clinicians who manage SJS/TEN should seek to employ interventions with the greatest impact on their patients' condition. While supportive care measures may seem an obvious aspect of SJS/TEN patient care, providers should understand that these interventions are imperative and that they differ from the care recommended for other critically ill or burn patients. While adjuvant therapies are frequently discussed and debated for hospitalized patients with SJS/TEN, a standardized management approach is not yet clear based on the current data. Therefore, until further data
Higher-order Zeeman and spin terms in the electron paramagnetic resonance spin Hamiltonian; their description in irreducible form using Cartesian, tesseral spherical tensor and Stevens' operator expressions
McGavin, Dennis G; Tennant, W Craighead
In setting up a spin Hamiltonian (SH) to study high-spin Zeeman and high-spin nuclear and/or electronic interactions in electron paramagnetic resonance (EPR) experiments, it is argued that a maximally reduced SH (MRSH) framed in tesseral combinations of spherical tensor operators is necessary. Then, the SH contains only those terms that are necessary and sufficient to describe the particular spin system. The paper proceeds then to obtain interrelationships between the parameters of the MRSH and those of alternative SHs expressed in Cartesian tensor and Stevens operator-equivalent forms. The examples taken, initially, are those of Cartesian and Stevens' expressions for high-spin Zeeman terms of dimension BS 3 and BS 5 . Starting from the well-known decomposition of the general Cartesian tensor of second rank to three irreducible tensors of ranks 0, 1 and 2, the decomposition of Cartesian tensors of ranks 4 and 6 are treated similarly. Next, following a generalization of the tesseral spherical tensor equations, the interrelationships amongst the parameters of the three kinds of expressions, as derived from equivalent SHs, are determined and detailed tables, including all redundancy equations, set out. In each of these cases the lowest symmetry, 1-bar Laue class, is assumed and then examples of relationships for specific higher symmetries derived therefrom. The validity of a spin Hamiltonian containing mixtures of terms from the three expressions is considered in some detail for several specific symmetries, including again the lowest symmetry. Finally, we address the application of some of the relationships derived here to seldom-observed low-symmetry effects in EPR spectra, when high-spin electronic and nuclear interactions are present.
大嶋, 繁; 羽鳥, 有紀子; 本間, 精一; 寺澤, 捷年; 齋藤, 侑也; 小林, 大介
Reports have indicated a relationship between adverse drug reaction (ADR) and Human Leukocyte Antigen (HLA) polymorphism and a relationship between Body Constitution (BC) and HLA polymorphism. Thus, a relationship between ADR and BC is suggested. We therefore created a questionnaire (hereinafter “Questionnaire”) to survey the typical BC of Stevens-Johnson Syndrome (SJS) patients to determine how they differ from healthy persons, and studied the relationship between the development of SJS and ...
Maverakis, Emanual; Wang, Elizabeth A; Shinkai, Kanade; Mahasirimongkol, Surakameth; Margolis, David J; Avigan, Mark; Chung, Wen-Hung; Goldman, Jennifer; La Grenade, Lois; Pirmohamed, Munir; Shear, Neil H; Tassaeeyakul, Wichittra; Hoetzenecker, Wolfram; Klaewsongkram, Jettanong; Rerkpattanapipat, Ticha; Manuyakorn, Wiparat; Yasuda, Sally Usdin; Sharon, Victoria R; Sukhov, Andrea; Micheletti, Robert; Struewing, Jeff; French, Lars E; Cheng, Michelle Y
Toxic epidermal necrolysis (TEN) and Stevens-Johnson Syndrome (SJS) are rare, acute, life-threatening dermatologic disorders involving the skin and mucous membranes. Research into these conditions is hampered by a lack of standardization of case reporting and data collection. To establish a standardized case report form to facilitate comparisons and maintain data quality based on an international panel of SJS/TEN experts who performed a Delphi consensus-building exercise. The elements presented for committee scrutiny were adapted from previous case report forms and from PubMed literature searches of highly cited manuscripts pertaining to SJS/TEN. The expert opinions and experience of the members of the consensus group were included in the discussion. Overall, 21 out of 29 experts who were invited to participate in the online Delphi exercise agreed to participate. Surveys at each stage were administered via an online survery software tool. For the first 2 Delphi rounds, results were analyzed using the Interpercentile Range Adjusted for Symmetry method and statements that passed consensus formulated a new case report form. For the third Delphi round, the case report form was presented to the committee, who agreed that it was "appropriate and useful" for documenting cases of SJS/TEN, making it more reliable and valuable for future research endeavors. With the consensus of international experts, a case report form for SJS/TEN has been created to help standardize the collection of patient information in future studies and the documentation of individual cases.
Full Text Available Stevens-Johnson syndrome (SJS and toxic epidermal necrolysis (TEN are severe drug hypersensitivities with high mortality. Typical over-the-counter drugs of cold medicines are suggested to be causative. As multiple ingredients are generally contained in cold medicines, it is of particular interest to investigate which ingredients are responsible for SJS/TEN. However, experimental examination of causal relationships between SJS/TEN and a particular drug molecule is not straightforward. Significant association between HLA-A*02:06 and SJS/TEN with severe ocular surface complications has been observed in the Japanese. In the present study, we have undertaken in silico docking simulations between various ingredients contained in cold medicines available in Japan and the HLA-A*02:06 molecule. We use the composite risk index (CRI that is the absolute value of the binding affinity multiplied by the daily dose to assess the potential risk of the adverse reactions. The drugs which have been recognized as causative drugs of SJS/TEN in Japan have revealed relatively high CRI, and the association between SJS/TEN and HLA-A*02:06 has been qualitatively verified. The results have also shown that some drugs whose links to SJS/TEN have not been clinically recognized in Japan show the high CRI and suggested that attention should be paid to their adverse drug reactions.
Full Text Available Toxic epidermal necrolysis (TEN is a rare but life-threatening skin disease that is most commonly drug-induced. It has recently been suggested that Stevens-Johnson syndrome (SJS belongs to the same group of skin disorders, although it has a lower mortality rate than TEN. We report the case of a 26-year-old male schizophrenic patient with a history of carbamazepine-induced SJS 5 years earlier. At the time of his current admission, he was admitted to our psychiatry department with acute agitation due to schizophrenia. However, the patient and his family denied history of drug allergy. After 3 days of carbamazepine treatment, the patient developed TEN (body surface area > 90%. He was transferred to the burn center, but despite appropriate treatment, including intravenous hydrocortisone 200 mg q6h and being covered with sterile biological material, he died. It is important to note that re-administration of a drug that previously caused SJS may lead to TEN, which has a very high mortality rate.
Mariane Ferreira Barbosa Emerick
Full Text Available Objetivou-se analisar as características demográficas e clínicas dos clientes diagnosticados com Síndrome de Stevens Johnson (SSJ e Necrólise Epidérmica Tóxica (NET, bem como identificar as ações dos profissionais de saúde para o manejo das Reações Adversas a Medicamentos (RAM em um hospital público do Distrito Federal. Pesquisa descritiva, retrospectiva, com abordagem quantitativa. Dados coletados em todos os prontuários de 22 clientes internados de janeiro de 2005 a setembro de 2012. Análise mediante estatística descritiva. Houve aumento gradativo de casos, com maior número nos anos de 2007 e 2012. Dos casos analisados, 9 foram diagnosticados com NET e 7 com SSJ; predominaram as mulheres (14 e a faixa etária de 21 aos 40 anos (10; 21 obtiveram cura. Os fármacos associados a RAM mais frequentes foram os antiepilépticos (10. Observou-se fragilidade nos registros clínicos nos prontuários e nas ações de monitoramento de RAM no serviço estudado.
Kolstad, Henrik A; Garde, Anne Helene; Hansen, Åse Marie
We thank Dr Richard Stevens for his comments (1) on our recent article that showed no increased risk of breast cancer following recent night shift work when compared with recent day shift work (2). This finding was based on linkage of day-by-day information on working hours and breast cancer...... incidence data. Results are thus less likely to have been biased by differential misclassification than findings from earlier studies relying on self-report (3). We defined a night shift as ≥3 hours of work between 24:00-05:00 hours and a day shift as ≥3 hours work between 6:00-20:00 hours. This day shift...... definitions of shifts affect the risk of breast cancer, which will be possible using this type of data. We only had information on working hours from 2007 and onwards, and night shift work prior to 2007 could have confounded our analyses towards no effect but only if inversely associated with night shift work...
Kolstad, Henrik A; Garde, Anne Helene; Hansen, Åse Marie; Frydenberg, Morten; Christiansen, Peer; Vistisen, Helene Tilma; Bonde, Jens Peter E
We thank Dr Richard Stevens for his comments (1) on our recent article that showed no increased risk of breast cancer following recent night shift work when compared with recent day shift work (2). This finding was based on linkage of day-by-day information on working hours and breast cancer incidence data. Results are thus less likely to have been biased by differential misclassification than findings from earlier studies relying on self-report (3). We defined a night shift as ≥3 hours of work between 24:00-05:00 hours and a day shift as ≥3 hours work between 6:00-20:00 hours. This day shift definition did not exclude shifts starting before 05:00 or ending after 24:00 hours. However, this affected only 0.02% and 0.3% of all day shifts, respectively. This diminutive misclassification, that is expected to be non-differential, can hardly explain our negative findings. It is suggested that shifts that begin after 07:00 and end before 18:00 would constitute a more sensible baseline comparison group. Since the biological mechanism is not certain, it is not obvious to us if this will be a more appropriate reference than the present. However, we agree that future studies should test how different definitions of shifts affect the risk of breast cancer, which will be possible using this type of data. We only had information on working hours from 2007 and onwards, and night shift work prior to 2007 could have confounded our analyses towards no effect but only if inversely associated with night shift work in 2007 or later. We find this unlikely. Left truncation could also have biased findings towards the null. We therefore supplemented analyses of the total study population with analyses of the one-third of the population with first recorded employment in 2008 or later (the inception population). Even if the mean age was 35.5 years - and many undoubtedly had been working (with and without night shifts) prior to 2008 - this population should be less affected by such
Sant' Anna, Ana Estela B P P; Hazarbassanov, Rossen M; de Freitas, Denise; Gomes, José Álvaro P
To evaluate minor salivary glands and labial mucous membrane graft in patients with severe symblepharon and dry eye secondary to Stevens-Johnson syndrome (SJS). A prospective, non-comparative, interventional case series of 19 patients with severe symblepharon and dry eye secondary to SJS who underwent labial mucous membrane and minor salivary glands transplantation. A complete ophthalmic examination including the Schirmer I test was performed prior to and following surgery. All patients had a preoperative Schirmer I test value of zero. Nineteen patients with severe symblepharon and dry eye secondary to SJS were included in the study. There was a statistically significant improvement in the best spectacle-corrected visual acuity in eight patients (t test; p=0.0070). Values obtained in the Schirmer I test improved significantly in 14 eyes (73.7%) 6 months following surgery (χ(2) test; p=0.0094). A statistically significant increase in tear production (Schirmer I test) was found in eyes that received more than 10 glands per graft compared with eyes that received fewer glands (χ(2) test; p=0.0096). Corneal transparency improved significantly in 11 (72.2%) eyes and corneal neovascularisation improved significantly in five eyes (29.4%) (McNemar test; p=0.001 and p=0.0005). The symptoms questionnaire revealed improvement in foreign body sensation in 53.6% of the patients, in photophobia in 50.2% and in pain in 54.8% (Kruskal-Wallis test; p=0.0167). Labial mucous membrane and minor salivary glands transplantation were found to constitute a good option for the treatment of severe symblepharon and dry eye secondary to SJS. This may be considered as a step prior to limbal stem cell and corneal transplantation in these patients.
Stevens-Johnson syndrome and toxic epidermal necrolysis due to anticonvulsants share certain clinical and laboratory features with drug-induced hypersensitivity syndrome, despite differences in cutaneous presentations.
Teraki, Y; Shibuya, M; Izaki, S
Drug-induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is characterized by late disease onset, fever, rash, hepatic dysfunction, haematological abnormalities, lymphadenopathy and often, human herpesvirus (HHV) reactivation. The diagnosis of DIHS is based on the combined presence of these findings. Anticonvulsants are a major cause of DIHS and may also cause Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). We examined whether SJS/TEN due to anticonvulsants display similar clinical and laboratory features seen in DIHS. Patients diagnosed with SJS or TEN due to anticonvulsants (n = 8) were examined and their clinical features and laboratory findings were compared with patients with anticonvulsant-related DIHS (n = 6). Seven of the eight patients with SJS/TEN developed symptoms > 3 weeks after starting anticonvulsants. Hepatic dysfunction was present in six patients with SJS/TEN and five patients with DIHS. Leucocytosis and/or eosinophilia was noted in seven patients with SJS/TEN and four patients with DIHS. Only one patient in the SJS/TEN group had atypical lymphocytosis; this was present in four patients with DIHS. Reactivation of HHV-6 was detected in one of the four patients tested in the SJS/TEN group, although it was seen in five of the six patients with DIHS. TSJS/TEN due to anticonvulsants may exhibit some clinical and laboratory features of DIHS. The nature of the cutaneous involvement should be emphasized in the diagnosis of DIHS. © 2009 The Author(s). Journal compilation © 2009 British Association of Dermatologists.
Lu, Na; Rai, Sharan K; Terkeltaub, Robert; Kim, Seoyoung C; Menendez, Mariano E; Choi, Hyon K
HLA-B*5801 allele carriage (a strong determinant of allopurinol hypersensitivity syndrome) varies substantially among races, which may lead to racial disparities in the risk of Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) in the context of urate-lowering drug adverse events (ULDAEs). We examined this hypothesis in a large, racially diverse, and generalizable setting. Using a database representative of US hospitalizations (2009-2013), we investigated the racial distribution of hospitalized SJS/TEN (principal discharge diagnosis) as ULDAEs (ICD-9-CM Classification of External Causes). Our reference groups included the US Census population, US allopurinol users, and ULDAE hospitalizations without SJS/TEN. We identified 606 cases hospitalized for SJS/TEN as ULDAEs (mean age = 68 years; 44% male), among which there was an overrepresentation of Asians (27%) and Blacks (26%), and an underrepresentation of Whites (29%) and Hispanics (% too-low-to-report), compared with the US Census population (5%, 12%, 67%, and 15%, respectively). The hospitalization rate ratios for SJS/TEN among Asians, Blacks, and Whites were 11.9, 5.0, and 1.0 (referent), respectively. These associations persisted using other national referents. According to the NHANES 2009-2012, allopurinol constituted 96.8% of urate-lowering drug use, followed by probenecid (2.1%). These national data indicate that Asians and Blacks have a substantially higher risk of SJS/TEN as ULDAEs than Whites (or Hispanics), correlating well with corresponding frequencies of HLA-B*5801 in the US population (i.e., 7.4%, 4%, 1%, and 1%, respectively). Given its market dominance and established association with SJS/TEN, our findings support the use of vigilance in these minorities when considering allopurinol. Copyright © 2016 Elsevier Inc. All rights reserved.
Full Text Available Aim. To determine the probable causative factors, clinical features, and treatment outcomes of Stevens-Johnson syndrome (SJS, toxic epidermal necrolysis (TEN, and SJS-TEN overlap in children. Methods. A 20-year database review of all children diagnosed with SJS/TEN/SJS-TEN overlap at the King Chulalongkorn Memorial Hospital, Thailand. Results. 36 patients (M : F, 16 : 20 with the mean age of 9.2±4.0 years were identified. There were 20 cases of SJS, 4 cases of SJS-TEN overlap, and 12 cases of TEN. Drugs were the leading cause for the diseases (72.3%; antiepileptics were the most common culprits (36.1%. Cutaneous morphology at presentation was morbilliform rash (83.3%, blister (38.9%, targetoid lesions (25.0%, and purpuric macules (2.8%. Oral mucosa (97.2% and eye (83.3% were the 2 most common mucosal involvements. Majority of the cases (77.8% were treated with systemic corticosteroids, intravenous immunoglobulin, or both. Treatment outcomes between those who received systemic therapy and those who received only supportive care were comparable. Skin and eye were the principal sites of short-term and long-term complications. Conclusions. SJS/TEN are not common but are serious diseases which lead to significant morbidities in children. Early withdrawal of suspicious causes and meticulous supportive care are very important. This study found that the systemic therapy was not superior to supportive care because the treatment outcomes for both groups were comparable.
León Ruiz, Maria Juliana
Las reacciones alérgicas a medicamentos cutáneas severas (RAM) como el Síndrome Stevens Johnson (SJS) y la Necrólisis Epidérmica Tóxica (NET),caracterizadas por exantema, erosión de la piel y las membranas mucosas, flictenas, desprendimiento de la piel secundario a la muerte de queratinocitos y compromiso ocular. Son infrecuentes en la población pero con elevada morbi-mortalidad, se presentan luego de la administración de diferentes fármacos. En Asia se ha asociado el alelo HLA-B*15:02 como m...
Phasukkijwatana, Nopasak; Lertrit, Patcharee; Liammongkolkul, Sompong; Prabhasawat, Pinnita
To compare the concentrations of epitheliotrophic factors in autologous serum eye drops (ASE) prepared from sera of chronic Stevens-Johnson syndrome (SJS) patients with dry eyes to those prepared from non-autoimmune dry eye controls and to study the stability of the epitheliotrophic factors in different storage conditions. Twenty-percent ASE were prepared from 10 chronic SJS patients with dry eyes and 10 age-matched non-autoimmune dry eye controls. The concentrations of major epitheliotrophic factors comprising epidermal growth factor (EGF), transforming growth factor-beta1 (TGF-β1), transforming growth factor-beta2 (TGF-β2), and fibronectin in those ASE preparations were determined by enzyme-linked immunosorbent assay (ELISA) at baseline and after different storage conditions: at 4 °C for 1 week and 1 month; and at -20 °C for 1, 3 and 6 months. There were no significant differences in the concentrations of EGF, TGF-β1, TGF-β2 and fibronectin in 20% ASE between the SJS and control groups (EGF: 176.9 ± 40.9 vs. 185.5 ± 36.9 pg/mL, TGF-β1: 9.5 ± 2.1 vs. 9.5 ± 1.9 ng/mL, TGF-β2: 55.3 ± 30.0 vs. 63.91 ± 45.6 pg/mL and fibronectin: 70.5 ± 20.2 vs. 62.2 ± 21.3 µg/mL, respectively). These factors were stable at 4 °C for up to 1 month. Storage at -20 °C for up to 6 months resulted in a slight decrease in TGF-β1 (SJS: from 9.5-8.4 ng/mL, p dry eye patients, and that ASE should be sufficiently stable for up to 6 months, if stored properly at -20 °C.
Full Text Available Etienne Février : I would like to begin this interview with a question about architecture. Images of architecture appear frequently in your fiction, from Martin Dressler to more recent collections like Dangerous Laughter. In that collection’s “thirteen stories,” we find a tower reaching all the way to heaven, a life-size replica of a town so precise that even the “levels of salt in the saltshakers” match those of the original town, and a series of outwardly expanding domes—covering a house, f...
Kahle, Sue C.; Taylor, William A.; Lin, Sonja; Sumioka, Steven S.; Olsen, Theresa D.
A study of the water resources of the unconsolidated groundwater system of the Chamokane Creek basin was conducted to determine the hydrogeologic framework, interactions of shallow and deep parts of the groundwater system with each other and the surface-water system, changes in land use and land cover, and water-use estimates. Chamokane Creek basin is a 179 mi2 area that borders and partially overlaps the Spokane Indian Reservation in southern Stevens County in northeastern Washington State. Aquifers within the Chamokane Creek basin are part of a sequence of glaciofluvial and glaciolacustrine sediment that may reach total thicknesses of about 600 ft. In 1979, most of the water rights in the Chamokane Creek basin were adjudicated by the United States District Court requiring regulation in favor of the Spokane Tribe of Indians' senior water right. The Spokane Tribe, the State of Washington, and the United States are concerned about the effects of additional groundwater development within the basin on Chamokane Creek. Information provided by this study will be used to evaluate the effects of potential increases in groundwater withdrawals on groundwater and surface-water resources within the basin. The hydrogeologic framework consists of six hydrogeologic units: The Upper outwash aquifer, the Landslide Unit, the Valley Confining Unit, the Lower Aquifer, the Basalt Unit, and the Bedrock Unit. The Upper outwash aquifer occurs along the valley floors of the study area and consists of sand, gravel, cobbles, boulders, with minor silt and (or) clay interbeds in places. The Lower aquifer is a confined aquifer consisting of sand and gravel that occurs at depth below the Valley confining unit. Median horizontal hydraulic conductivity values for the Upper outwash aquifer, Valley confining unit, Lower aquifer, and Basalt unit were estimated to be 540, 10, 19, and 3.7 ft/d, respectively. Many low-flow stream discharge measurements at sites on Chamokane Creek and its tributaries
Full Text Available Cet article a pour objet de présenter brièvement le fonds de l’atelier Hébert-Stevens - Bony, entré aux Archives nationales (Archives nationales du monde du travail, Roubaix en 2002
Case Report: Stevens-Johnson syndrome following a single double dosing of nevirapine-containing regimen once in an HIV-infected woman on long-term antiretroviral therapy. [version 1; referees: 1 approved, 2 approved with reservations
Full Text Available A 31-year old HIV-infected African woman on nevirapine, tenofovir and lamivudine for more than 4 years presented with an 8-day history of symptoms and signs of Stevens-Johnson syndrome. She was on no other medication. Her viral load was undetectable and she had maintained a CD4 count of between 356 and 387cells/mm3 in the preceding 2½ years. She missed her antiretrovirals 10 days before the onset of her symptoms and subsequently doubled her daily dose the following day. She had been on no other medication in the preceding 8 weeks. Her ARVs were stopped and she fully re-epithelialized with the exception of the lips, over the following 10 days. She was started on a daily single tablet of Odimune® (a fixed drug combination antiretroviral containing tenofovir, emtricitabine and efavirenz. Nevirapine is the most common offender in cases of antiretroviral-associated SJS in published literature. Lamivudine is very rarely implicated while there are no similar reports with tenofovir. We concluded that nevirapine was by far the most likely offender in this case. Nevirapine toxicity is associated with high CD4 counts, undetectable viral load and high drug plasma level. We postulate that the sudden increase of the plasma levels of nevirapine in a patient with a high CD4 count and undetectable viral load created a perfect storm for the development of SJS in our patient, who had been on the NVP-containing regimen for many years. Clinicians should be aware that severe adverse drug reactions are dynamic and can occur even when the drug has been in use for a long time.
Kakande, Betty; Isaacs, Thuraya; Muloiwa, Rudzani; Dlamini, Sipho; Lehloenya, Rannakoe
A 31-year old HIV-infected African woman on nevirapine, tenofovir and lamivudine for more than 4 years presented with an 8-day history of symptoms and signs of Stevens-Johnson syndrome. She was on no other medication. Her viral load was undetectable and she had maintained a CD4 count of between 356 and 387cells/mm (3) in the preceding 2½ years. She missed her antiretrovirals 10 days before the onset of her symptoms and subsequently doubled her daily dose the following day. She had been on no other medication in the preceding 8 weeks. Her ARVs were stopped and she fully re-epithelialized with the exception of the lips, over the following 10 days. She was started on a daily single tablet of Odimune® (a fixed drug combination antiretroviral containing tenofovir, emtricitabine and efavirenz). Nevirapine is the most common offender in cases of antiretroviral-associated SJS in published literature. Lamivudine is very rarely implicated while there are no similar reports with tenofovir. We concluded that nevirapine was by far the most likely offender in this case. Nevirapine toxicity is associated with high CD4 counts, undetectable viral load and high drug plasma level. We postulate that the sudden increase of the plasma levels of nevirapine in a patient with a high CD4 count and undetectable viral load created a perfect storm for the development of SJS in our patient, who had been on the NVP-containing regimen for many years. Clinicians should be aware that severe adverse drug reactions are dynamic and can occur even when the drug has been in use for a long time.
Cost-effectiveness analysis of HLA-B*58: 01 genetic testing before initiation of allopurinol therapy to prevent allopurinol-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in a Malaysian population.
Chong, Huey Yi; Lim, Yi Heng; Prawjaeng, Juthamas; Tassaneeyakul, Wichittra; Mohamed, Zahurin; Chaiyakunapruk, Nathorn
Studies found a strong association between allopurinol-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and the HLA-B*58:01 allele. HLA-B*58:01 screening-guided therapy may mitigate the risk of allopurinol-induced SJS/TEN. This study aimed to evaluate the cost-effectiveness of HLA-B*58:01 screening before allopurinol therapy initiation compared with the current practice of no screening for Malaysian patients with chronic gout in whom a hypouricemic agent is indicated. This cost-effectiveness analysis adopted a societal perspective with a lifetime horizon. A decision tree model coupled with Markov models were developed to estimate the costs and outcomes, represented by quality-adjusted life years (QALYs) gained, of three treatment strategies: (a) current practice (allopurinol initiation without HLA-B*58:01 screening); (b) HLA-B*58:01 screening before allopurinol initiation; and (c) alternative treatment (probenecid) without HLA-B*58:01 screening. The model was populated with data from literature review, meta-analysis, and published government documents. Cost values were adjusted for the year 2016, with costs and health outcomes discounted at 3% per annum. A series of sensitivity analysis including probabilistic sensitivity analysis were carried out to determine the robustness of the findings. Both HLA-B*58:01 screening and probenecid prescribing were dominated by current practice. Compared with current practice, HLA-B*58:01 screening resulted in 0.252 QALYs loss per patient at an additional cost of USD 322, whereas probenecid prescribing resulted in 1.928 QALYs loss per patient at an additional cost of USD 2203. One SJS/TEN case would be avoided for every 556 patients screened. At the cost-effectiveness threshold of USD 8695 per QALY, the probability of current practice being the best choice is 99.9%, in contrast with 0.1 and 0% in HLA-B*58:01 screening and probenecid prescribing, respectively. This is because of the low incidence of
Leedu presidendi Rolandas Paksase ümber vallandunud skandaali üks võtmeisikuid, Vene kodanik Juri Borissov teatas, et hakkab tööle presidendi ühiskondliku nõunikuna, mõni tund hiljem otsustas president distantseeruda oma valimiskampaania suursponsorist
Leedu ametieetika peakomisjon otsustas, et ametist tagandatud ekspresident Rolandas Paksas ei saa kolm aastat riigiametites töötada. See otsus võib takistada Paksase kandideerimist ennetähtaegsetel presidendivalimistel. Vt. samas: And here's the competition...
Gajek, Z.; Mulak, J.
General expressions for reduction coefficients of matrix elements of angular momentum operator in ionic clusters or molecular systems have been derived. The reduction in this approach results from overlap and covalency effects and plays an important role in the reconciling of magnetic and spectroscopic experimental data. The formulated expressions make possible a phenomenological description of the effect with two independent parameters for typical equidistant clusters. Some detailed calculations also suggest the possibility of a one-parameter description. The results of these calculations for some ionic uranium compounds are presented as an example.
Vilniuse linnapea Arturas Zuokas kuulati üle seoses võimaliku häälteostmisega kohalike omavalitsuste valimistel. A. Zuokas peab ülekuulamise põhjuseks president Rolandas Paksase survet uurimisorganitele
Läti transpordiministeerium avaldas riigi teedevõrgu arengukava järgmiseks 25 aastaks, mille kohaselt investeeritakse maanteede ja raudteede ehitusse kuni 18 miljardit litti. Leedu transpordiettevõtjate hinnangul ei ole uued suuremahulised projektid majandusarengu seisukohalt vajalikud
addiction to foreign oil, address the global climate crisis and create millions of new jobs. Prior to his , the Korean Academy of Sciences and Technology and numerous other civic and professional organizations
African Health Sciences. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 5, No 4 (2005) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register · Download this PDF file. The PDF file you selected should load here ...
Vene peaprokuratuur andis välja rahvusvahelise vahistamisorderi Mazheikiu Nafta juhatuse esimehe ja Jukose aktsionäri Mihhail Brudno suhtes. Leedu valitsus kaalub võimalikke samme, sealhulgas Mazheikiu Nafta aktsiate tagasiostmist
Bruno, Michael S; Blumberg, Alan F
.... In the long-term, the observation and modeling systems will be linked in a unique fashion, whereby the model forecast system will be enhanced by data assimilation, and the observing system will...
Leedu presidendi ümber puhkenud skandaali uuriv Seimi erikomisjon leidis, et president Rolandas Paksas oli ja on oma sidemete tõttu haavatav ning see kujutab ohtu riigi julgeolekule. Lisa: Commission conclusions
Leedu valitsus seiskab tõenäoliselt elektrijaotusvõrgu Rytu Skirstomieji Tinklai (RTS) erastamise. Teise võrgufirma Vakaru Skirstomieji Tinklai (VST) erastamiskomisjon on palunud konkursil osalejatelt täpsustatud pakkumisi
Stephen Hawking will visit Texas A&M University from Feb. 24 to March 21 2003 to participate in the inaugural meeting of the George P. and Cynthia W. Mitchell Institute for Fundamental Physics. This institute will bring several of the world's top physicists to A&M for a month-long exploration of the latest ideas on topics ranging from superstrings to M-theory and supergravity (1/2 page).
on the development, physiology, and disease of living things. I have a ... Vogel was a prolific writer of popular science articles and books. .... is a new line of thinking here. Even though the .... to make it suitable to teach engineering stu- dents?
Vilniuse linnapea Arturas Zuokase suhtes on algatatud kriminaalmenetlus, süüdistuseks koos korporatsiooni Rubicon juhi Andrius Janukonisega altkäemaksu pakkumine linnavolikogu liikmele Vilmantas Dremale linnapea valimiste eel
Leedu Sotsiaaldemokraatliku Partei liikme, Euroopa Parlamendi saadiku Aloyzas Sakalase hinnangul finantseeritakse Leedu parteisid altkäemaksudest ja korruptsioonis süüdistatavad parlamendiliikmed tegutsesid oma parteide nimel
Leedu Seimi korruptsioonivastase võitluse komisjon otsustas avalikustada parlamendiliikmete Vytenis Andriukaitise, Vytautas Kvietkauskase ja Arvydas Vidziunase telefonikõnede lindistused, mis tõendavad, et nad võtsid altkäemaksu kontserni Rubicon Group juhilt Andrius Janukoniselt
... for comment are not required pursuant to 5 U.S.C. 553, or any other law, the analytical requirements..., rod and reel, spear, trap, slurp gun, hand harvest. C. Charter fishery C. Bandit gear, buoy gear..., gillnet, hand harvest, seine, slurp gun, trap, spear, rod and reel, hook and line. 12. Recreational...
illness until research found that morbidity can result from a ... for the widespread keratinocyte necrosis in SJS and TEN.⁷. Granulysin is the most ... Clinical presentation. SJS and ... Burns Intensive Care Unit may be one of the most important.
Inimõiguste ekspertide uuring näitab, et nii Leedu presidendi Rolandas Paksase administratsiooni töötajad, presidendi tegevuse uurijad kui ka Leedu ajakirjandus rikkusid mitmeid inimõigusi, eelkõige aga õigust privaatsusele
Vilniuse linnapea, Leedu Liberaaltsentristliku Liidu liider Arturas Zuokas süüdistab ajalehe Respublika peatoimetajat Vitas Tomkust väljapressimises. Ajaleht on avaldanud mitu Zuokase jaoks ebameeldivat artiklit, milles räägitakse tema väidetavatest sidemetest vastuolulise mainega ettevõtjatega
Pärast EL-iga liitumist on Balti riikides hinnad tõusnud keskmiselt 5,7%, pankade hinnangul on oodata ka inflatsiooni kiirenemist. Lisa: Thank you, accession: Consumer Price Index, percent increase, year-on-year
Bruno, Michael S; Blumberg, Alan F
... for the real-time assessment of ocean, weather, environmental, and vessel traffic conditions throughout the New York Harbor region, and the forecast of conditions in the near and long-term and under specific threat scenarios...
group development and social capital formation. .... This model of group development is therefore a successive-stage theory as it ... learning or development. .... Bandura (1986) stated that group efficacy “ will influence what people will do as a.
... for Sustainable Fisheries, Northeast Region, NMFS (Assistant Regional Administrator), has made a.... SUPPLEMENTARY INFORMATION: An application for an EFP was submitted by the University of Maryland Eastern Shore (UMES) on February 18, 2011, in support of a project preliminarily selected under the New England and...
... fishing. SUMMARY: The Regional Administrator for Sustainable Fisheries, Northeast Region, NMFS, has issued a revised EFP in support of a drop chain small mesh net study conducted by the University of Rhode... temporarily retained for data collection purposes. Field work for this project began in April 2010, and 8 of...
..., cowcod, and yelloweye rockfish. Order on Remedy, Dkt. No. 342 (April 29, 2010) (Opinion). The Court held... Order on Remedy, Dkt. No. 342 (April 29, 2010). For darkblotched rockfish, NMFS notes that modifying the...
... the Atlantic surfclam and ocean quahog Georges Bank Closure Area. This would continue research to... testing to obtain additional data in locations where toxin levels may be higher than were present during the pilot phase of the study. NMFS has made a preliminary determination that the exempted fishing...
... Atlantic surfclam and ocean quahog Georges Bank Closure Area to continue testing the safety and efficacy of... research project that has been ongoing since 2006. NMS has made a preliminary determination that the...: http://www.nero.noaa.gov/sfd/clams . This project is a pilot program with the goal of determining if...
...) Georges Bank winter flounder. Sec. 648.86(l) Zero retention of Atlantic wolffish. Sec. 648.86(o..., fecundity, bioelectrical impedance analysis (BIA), food habits, and genetic research. The yellowtail... (GOM), Georges Bank (GB), Southern New England/Mid-Atlantic (SNE/MA)), or 1,200 fish total from each...
... rule; request for comments. SUMMARY: NMFS proposes to open a portion of the Georges Bank (GB) Closed... the presence of toxins known to cause paralytic shellfish poisoning (PSP). The U.S. Food and Drug... these trips to enter the food market. On January 21, 2010, NMFS received a letter from the FDA...
... monkfish for sale, but the sampling locations are determined by CCE. To conduct compensation fishing in... as to how the waiver could influence fishing behavior, and if it could increase the likelihood of an... white hake and witch flounder, which would be landed for commercial sale. All catch of Northeast...
... the influence of temperature on monkfish distribution and abundance. Regulations under the Magnuson... goal of this study is to investigate the influence of temperature on monkfish distribution and... use standard commercial gear and land monkfish for sale. Monkfish EFPs that waive possession limits...
... shell and egg-bearing lobsters. The commenters state that lobster fishing takes place in the southern... fewer dredges and shorter dredge time anticipated in an area of high biomass such as GB. This fishery is... from the three gears being used together in this area. However, because the biomass of surfclams and...
... optimum yield. This action would also continue to suspend the minimum shell size for Atlantic surfclams... still above the biomass target reference points. Based on this information, the Council is recommending...
... continues to suspend the minimum shell size for Atlantic surfclams for the 2014 fishing year. DATES: This... relatively low fishing mortality, the stock is still above the biomass target reference points. This action...
... management measures. * * * * * (c) * * * (1) * * * (ii) Differential trip landing limits and frequency limits based on gear type, closed seasons, and bycatch limits. Trip landing and frequency limits that differ by... Arena South Biogenic Area, Cordell Bank/Biogenic Area, Farallon Islands/Fanny Shoal, Half Moon Bay...
Leedu kaitseminister Linas Linkevicius räägib rahvusvahelistes rahuvalveoperatsioonides osalemise tähtsusest, Leedu - USA tihedast koostööst ning käimasoleva presidendiskandaali mõjust Leedu rahvusvahelisele mainele
Taagepera, Rein, 1933-
Autorid võrdlevad eri maade esinduskogude kodade suurust ja elanike arvu neis maades ning arutlevad, kui suur kohtade arv peaks olema Euroopa Liidu Nõukogus ja Euroopa Parlamendis. Tabelid, diagrammid
... information on three types of proposed changes. NMFS begins with proposed changes that concern the expanded... could be disclosed. This interpretation of limited access program would include specific types of... section 402(b)(1)(D). Unless expressly waived by Congress, sovereign immunity precludes state court...
... disruption to summer fisheries, as no additional restrictions to fishery management measures are necessary at... impacts within the lowered yelloweye rockfish OY in accordance with the court's order; makes routine in...
... the appropriate [sigma] value the Council chooses a P star (P*) based on its chosen level of risk aversion considering the scientific uncertainties. As the P* value is reduced, the probability of the ABC... additional reduction for scientific uncertainty beyond the sigma value reduction. A lower P* is more risk...
... communities, and will provide more flexibility for negotiating annual catches with Canada. 3. Overfishing... overfishing, rebuild overfished stocks, achieve optimum yield, and ensure that management measures are based... established accountability measures (AMs) for the 20 groundfish stocks in order to prevent overfishing of...
... and marketing evaluation and strategies; and outreach and implementation of the project results. The... devise strategies and means to efficiently harvest the redfish resource in the Gulf of Maine (GOM) while... in terms of their potential effects on results. Sources of variability include: Area fished; seasonal...
merely hint at the gruesome reality in Nazi Germany. With the hindsight granted to present-day readers, we know the fate that awaited these men and women as an elongated and agonising social death reached its culmination in systematic mass murder. In describing his journeys to Germany,. Poland, Israel and the United ...
... and ocean quahogs from the Exclusive Economic Zone to prevent overfishing and to allow harvesting of... appropriate. The fishing quotas must be in compliance with overfishing definitions for each species. In... same ocean quahog overfishing definition. When the two quota amounts (ocean quahog and Maine ocean...
... programs for NE multispecies stocks newly classified as being overfished and subject to overfishing; and to... to end overfishing, rebuild overfished regulated NE multispecies and ocean pout stocks, and mitigate... and subject to overfishing, and that stocks currently classified as overfished require additional...
... to reduce overfishing occurring on Gulf of Maine cod in anticipation of further action to end overfishing in the 2013 fishing year. DATES: The expiration date of the temporary rule published May 1, 2012..., overfishing of GOM cod while the Council developed a rebuilding plan. In response to the Council request and...
... harvest as intended by the Council in fisheries that are important to coastal communities in a manner that... actions need to be in effect. For the actions to be implemented in this final rule, affording the time... of the Pacific Coast Groundfish FMP goals and objectives of preventing overfishing and rebuilding...
... are available, preventing additional harvest in fisheries that are important to coastal communities... document and undergo proposed and final rulemaking before these actions need to be in effect. For the... delay could impair achievement of one of the Pacific Coast Groundfish FMP goals to prevent overfishing...
... Analyst, phone: 978-281-9257, fax: 978-281-9135. SUPPLEMENTARY INFORMATION: Background The NE Multispecies... acceptable biological catches (ABCs) and ACLs for regulated species and ocean pout, as well as distributing... (Framework 44) set the ABCs and ACLs for FYs 2010-2012. In 2011, Framework 45 to the NE Multispecies FMP...
... 02543-1026, or online at: www.nefsc.noaa.gov/nefsc/publications/ . The revised EFP would exempt vessels.... Category F vessels would be charged monkfish RSA DAS at a higher pro- rated rate of 2.909:1 RSA DAS for... tail-to-whole-weight conversion factor from 3.32 to 2.91, which essentially reduced the whole weight...
... increase in biomass and recruitment on Georges Bank and off Long Island, NY. Based on this information, the..., stock recruitment, projected fishing effort and catches, and areas closed to fishing. In June 2010, the... Quahogs \\3\\ 100,000 35,240 100,000 35,240 100,000 35,240 \\1\\ Numerical values are in millions except for...
... overfishing and was overfished. A new benchmark assessment (SARC 54) was completed for this stock in June 2012... stock was overfished. Final results from the February 2013 benchmark assessment for white hake are... Management Council (Council) as part of the biennial review process to respond to updated stock information...
... adopted an FY 2013 ABC for white hake based on the 2008 benchmark assessment for this stock, which was the... estimate current stock size and fishing mortality, and this model was approved at the last benchmark... hake benchmark stock assessment (SARC 56) was completed in February 2013. The results of the assessment...
... assessment for white hake was completed in 2008. A benchmark assessment for this stock was completed in... years (FYs) 2013-2015, including 2013 total allowable catches (TACs) for the three U.S./Canada stocks... management measures for this stock consistent with the proposed rebuilding strategy. This action also...
... updated peer-reviewed benchmark stock assessment conducted in July 2010 (Stock Assessment Workshop, or SAW..., including preventing overfishing, rebuilding overfished stocks, achieving optimum yield (OY), and minimizing... revises the biological reference points and stock status for pollock, updates annual catch limits (ACLs...
... monitor recruitment, benefits, insurance and taxes; logistical costs associated with deployment; and at..., such as logistical costs generated by deployment, which are outside its statutory obligations under the... measures in Framework 48: A provision for cost- sharing of monitoring costs between the industry and NMFS...
... surfclam/ocean quahog cage, and would allow project participants to test alternatives to the industry... applicant stated that offloading into cages can be burdensome and dangerous and the extra handling and the... proposed research and have minimal impacts that do not change the scope or impact of the initially approved...
.... Amendment 16 also stated that each sector would develop an at-sea monitoring plan to monitor bycatch across... industry-funded at-sea monitoring program for sector trips targeting redfish with trawl nets with mesh... to have an observer or at-sea monitor on board. Mesh sizes are measured as described at 50 CFR 648.80...
... Atmospheric Administration (NOAA), Commerce. ACTION: Proposed rule; request for comments. SUMMARY: NMFS... border between the United States and Canada, the Hague Line, and is a U.S./Canada shared stock. The... promulgate emergency rules or interim measures ``to address the emergency or overfishing.'' (16 U.S.C. 1855(c...
... that boat too much quota to catch. Response: FFP lending decisions and fishery management decisions are... FFP direct lending is subject to the above general credit standards and requirements found in Sec. Sec...) Credit decision. (1) The Program shall issue to approved applicants an AIP letter, which shall describe...
..., has been closed to the harvest of surfclams and ocean quahogs since 1990 due to red tide blooms that... surfclams and ocean quahogs since 1990 due to red tide blooms that cause PSP, without resulting in...; Fisheries of the Northeastern United States; Atlantic Surfclam and Ocean Quahog Fishery AGENCY: National...
... surfclams and ocean quahogs since 1990 due to red tide blooms that cause paralytic shellfish poisoning (PSP...; Fisheries of the Northeastern United States; Atlantic Surfclam and Ocean Quahog Fishery AGENCY: National... Area to the harvest of Atlantic surfclams and ocean quahogs. The area has been closed since 1990 due to...
... closed to the harvest of surfclams and ocean quahogs since 1990 due to red tide blooms that cause...; Atlantic Surfclam and Ocean Quahog Fishery AGENCY: National Marine Fisheries Service (NMFS), National... portion of the Georges Bank Closed Area to the harvest of Atlantic surfclams and ocean quahogs. The full...
Valge Maja ökonomist Austan Goolsbee vastab küsimustele, mis puudutavad riigi keskset kontrolli majanduse üle, maksumäära tõstmist rikkamatel maksumaksjatel, majanduskasvu juhtimist tulevikus, kultuurilisi muutusi, ideaalset maksumäära ning hüperinflatsiooni võimalikkust
... accounting concept as described in the FW 50 final rule and outlined in Sec. 648.87(b)(1)(i)(G)(1) through (5... Catch Entitlement (ACE) carryover accounting for FY2014 and beyond. For Sector Operations Plans: A...
... longer, which could increase interactions with protected resources and trigger additional management... action is necessary to help mitigate expected adverse economic and social harm resulting from substantial... biological, economic, and social impact analysis for this action are contained in the environmental...
..., Newburyport, MA 01950. The FEIS/RIR/IRFA is also accessible via the internet at http://www.nero.nmfs.gov . You... accept anonymous comments (enter ``N/A'' in the required fields if you wish to remain anonymous...
... or protected information. NMFS will accept anonymous comments (if submitting comments via the Federal Rulemaking portal, enter ``N/A'' in the relevant required fields if you wish to remain anonymous... Access This notice is accessible via the Internet at the Office of the Federal Register's Web site at...
... voluntarily by the sender will be publicly accessible. NMFS will accept anonymous comments (enter ``N/A'' in the required fields if you wish to remain anonymous). Attachments to electronic comments will be... . SUPPLEMENTARY INFORMATION: Electronic Access This document is accessible via the Internet at the Office of the...
... is also accessible via the Internet at http://www.nero.nmfs.gov . You may submit comments, identified... protected information. NMFS will accept anonymous comments (enter N/A in the required fields, if you wish to remain anonymous). You may submit attachments to electronic comments in Microsoft Word, Excel, Word...
..../Canada Management Area AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric... announces a temporary closure of the Eastern U.S./Canada Area to limited access Northeast (NE) multispecies days-at-sea (DAS) vessels and a prohibition on the harvest, possession, and landing of Georges Bank (GB...
Ignacio Senra Fernández-Miranda
Full Text Available RESUMEN Poco tiene que ver la edición original de 1972 de Learning from las Vegas, the forgotten symbolism of the architectural form, con la edición revisada de 1977, que fue traducida al español y publicada por Gustavo Gili en 1978. El gran formato del libro original (38x28cm se justificaba por la importancia del material gráfico desplegado, un ejercicio de análisis que aspiraba a descubrir nuevas técnicas de representación capaces de reproducir una realidad tan compleja sensorialmente como la de la ciudad de las Vegas. La drástica transformación, impulsada por los propios autores, suponía un abaratamiento y por tanto una mayor difusión del libro, pero sobretodo trataba de acabar con el conflicto entre su crítica al diseño Bauhaus y el diseño Bauhaus tardío del libro original, como señaló la propia Denise Scott Brown en el prologo de la edición revisada de 1977.
This paper has reviewed three cases of erythema multiforme major who presented with ocular complications. In one of the cases, the patient became blind because of mismanagement. The precipitating factors in the three patients were a herbal remedy, Fansidar® (Sulfadoxine 500mg; Pyrimethamine 25mg) and ...
... (50 CFR part 660, subparts C through G). Changes to current groundfish management measures implemented... Groundfish Fishery Management Measures The State of Washington manages canary and yelloweye rockfish under a... guidelines for canary and/or yelloweye rockfish. During 2011, the Washington State Department of Fish and...
... decrease in estimated current abundance from the prior assessment. The SRG met in Seattle, Washington, from... that the current modeling approach, which implements a relatively simple base case in the Stock...[deg] N. lat. The 2012 allocations of Pacific Ocean perch, canary rockfish, darkblotched rockfish, and...
... final rule and current codified regulations that resulted from incorrect amendatory instructions in the... bag limit is 10 RCG Complex fish per day coastwide. Retention of canary rockfish, yelloweye rockfish...
... more heavily towards the most recent year, to predict how current management measures will affect the... bycatch rate of co-occurring overfished species, primarily widow rockfish and canary rockfish, in the... initial testing of the jig gear, some additional catch of widow rockfish and canary rockfish is...
... (50 CFR part 660, subparts C through G). Changes to current groundfish management measures implemented... indicate that the probability of encountering canary rockfish, darkblotched rockfish, Pacific ocean perch...
... collection-of-information requirements contained in this rule may be submitted to Alan Risenhoover, Director... basis for salary of Council executive directors be put on par with that of NMFS Regional Administrators... broadened and clarified to include any income, grant, or other monetary or in-kind remuneration received by...
... as another product form due to processing and/or marketing reasons. The Council further states that... Sec. 648.322(b) of the proposed regulations would have exempted vessels targeting skate that also... sector vessels could increase targeting of skates by these vessels. Response: The Council's Amendment 3...
... would not provide a viable targeting opportunity and will force fishers to target sablefish instead... action to reduce overall targeting of rockfish using hook and line gears, both commercial and... appropriate harvest levels while providing for fishing and marketing opportunities. Ultimately, taking the...
Vabariikliku noorte tantsijate X suvelaagri lõputööna etendub vabaõhumuusikal "Kaua võib" (stsenarist Rünno Karna, muusika autor ja projektijuht Kalle Erm, kunstnik Rait Potisepp, dirigent Hirvo Surva). Püünsi põhikooli tantsulapsed sellest, mis laagris meeltmööda ja mis mitte. Vastab ka laste õpetaja Hele Pomerants
... all of the required information and warrants further consideration. Study Fleet projects are managed by the University of Massachusetts Dartmouth School of Marine Science and Technology (SMAST). The EFP... INFORMATION CONTACT: Jason Berthiaume, Fishery Management Specialist, (978) 281-9177. SUPPLEMENTARY...
... . SUPPLEMENTARY INFORMATION: The School for Marine Science and Technology at the University of Massachusetts... would be conducted by the School for Marine Science and Technology at the University of Massachusetts... preliminary determination that an exempted fishing permit application contains all of the required information...
Full Text Available Stevens’s poems grant a curious status to material reality. Famously abstract, they refuse to abandon the realm of the material. Rather, “material reality” is inseparable from “abstract” concepts. Stevens’s position is pragmatist: the status and significance of material objects is founded by the entirely human linguistic/mental activity, which is also an interpretive activity. The poem is a site of initiating this activity. As such, Stevens’s poetics remains in opposition to other aesthetic positions: the linguistic idealism of Mallarmé, the metaphysical realism of Miłosz and Herbert, and the material realism of Ponge and American “objectivists”. While the metaphysical positions tend to overcome the material, the realistic poets will reify it by “taking the side of things”. Stevens’s poetic pragmatism sees no lure in the extra-material, while also refusing to see matter as meaningful in itself, beyond the human interpretive activity.
... public that NMFS is extending the deadline to join a sector for FY 2012 through April 30, 2012. NMFS is..., Northeast Fishery Sector IV and Sustainable Harvest Sector 3 would operate as private lease-only sectors... require a different scheme for determining each permit's potential sector contribution. Sector vessels are...
..., fax (978) 281-9135. SUPPLEMENTARY INFORMATION: A proposed rule soliciting public comment on 19 sector... 3, will operate as private lease-only sectors. The Sustainable Harvest Sector 3 has not explicitly... leases among vessels within individual sectors, as well as between vessels in different sectors, was...
... TINSS and SS model revealed that: (1) Agreement in fit to the acoustic survey biomass was better between.... During the comment period, NMFS received four letters of comment. The U.S. Department of Interior... from the U.S. and Canadian fisheries; and biomass indices from the Joint U.S.-Canadian acoustic...
Euroopa, sh Eesti sõltuvus Venemaa energiaressurssidest ja energeetiline julgeolek. Diagramm: Gaasi kasutamine Eestis. Arvamust avaldavad majandus- ja kommunikatsiooniministeeriumi energeetika osakonna juhataja Einari Kisel ja parlamendisaadik Marko Mihkelson
... through daily Vessel Monitoring System (VMS) catch reports, as is currently proposed through a regulatory..., transfer, receive, sell, purchase, trade, or barter; or attempt to transfer, receive, sell, purchase, trade, or barter, or sell more than 2,000 lb (907 kg) of Atlantic [[Page 42670
... and were not sold, bartered or traded. At the time, DAS was the only effort control for the FMP, and... current system does not accurately account for the disposition of fish landed under the ``home consumption... receipt of the TSH report via a back-up system specified by the DSM service provider. While the...
... Fishery Management Plan (FMP), are intended to allow fisheries to access more abundant groundfish stocks.... Because of the restructuring, beginning on November 1, 2010, these specifications and management measures... complexity of the biennial specifications and management measures, the need for adequate National...
... opportunities to harvest available healthy stocks and meet the objective of the Pacific Coast Groundfish FMP to... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration 50 CFR Part 660 [Docket No... Coast Groundfish Fishery; Inseason Adjustments to Fishery Management Measures AGENCY: National Marine...
... specifications and management measures for most species of the Pacific Coast groundfish fishery (75 FR 67810... mortality of overfished and target species are the result of management measures designed to achieve, to the... rebuilding of overfished stocks by remaining within their rebuilding ACLs. Limited Entry Fixed Gear Fishery...
... Multispecies Fishery Management Plan (FMP) and is intended to increase the likelihood of harvesting the total... action is being taken to allow vessels to fully harvest the TACs for transboundary stocks of GB cod... Management Area through April 30, 2010, to facilitate the harvest of the TAC while ensuring that the TAC will...
... for FYs 2010 and 2011. 7. Multispecies Minimum Fish Sizes and Fillet Provisions The current... (ACE) for the sector in which that vessel participates. Currently, fillets and parts of fish as... limits. That is, the regulations require the weight of fillets or parts of fish to be multiplied by 3 and...
... based on a linear interpolation of the bycatch rates for widow rockfish from 2006-2009. From the overall... defined by the RFA (although some of these vessels may be affiliated with larger processing companies... processing companies). Tribal trawlers are presumed to be small entities, whereas the Tribes are presumed to...
... collaborating with the Council on the development of stock- rebuilding measures over the months to come. The... months and measures would be implemented for the May 1 start of the fishing year. For the cycle leading...
... its intent to address the rebuilding needs and NMFS anticipates collaborating with the Council on the... for the May 1 start of the fishing year. For the cycle leading into fishing year 2012, the Council and...
... States; Northeast Multispecies Fishery; 2013 Sector Operations Plans and Contracts and Allocation of Northeast Multispecies Annual Catch Entitlements AGENCY: National Marine Fisheries Service (NMFS), National..., provide allocations of Northeast (NE) multispecies to these sectors, and grant regulatory exemptions. We...
... States; Northeast Multispecies Fishery; 2011 Sector Operations Plans and Contracts, and Allocation of Northeast Multispecies Annual Catch Entitlements AGENCY: National Marine Fisheries Service (NMFS), National.... SUMMARY: As part of the process for the NMFS Northeast Regional Administrator approval of proposed sector...
... States; Northeast Multispecies Fishery; Proposed Rule To Allow Northeast Multispecies Sector Vessels.... ADDRESSES: A copy of the accompanying environmental assessment is available from the NMFS Northeast Regional.... SUPPLEMENTARY INFORMATION: Background Amendment 16 to the Northeast Multispecies Fisheries Management Plan...
... Northeastern United States; Northeast Multispecies Fishery; Final Rule To Allow Northeast Multispecies Sector... allows fishing access for Northeast multispecies sectors to two portions of the Southern New England... of the accompanying environmental assessment is available from the NMFS Northeast Regional Office...
... States; Northeast Multispecies Fishery; 2013 Sector Operations Plans and Contracts and Allocation of Northeast Multispecies Annual Catch Entitlements AGENCY: National Marine Fisheries Service (NMFS), National... year (FY) 2013, providing allocations of Northeast (NE) multispecies to these sectors, and granting 23...
... States; Northeast Multispecies Fishery; 2010 Sector Operations Plans and Contracts, and Allocation of Northeast Multispecies Annual Catch Entitlements AGENCY: National Marine Fisheries Service (NMFS), National... approval on a parallel track with Amendment 16 to the Northeast (NE) Multispecies Fishery Management Plan...
This graduate level textbook on Condensed Matter Physics is written lucidly by two leading luminaries in this field. The volume draws its material from the graduate course in condensed matter physics that has been offered by the authors for several decades at the University of California, Berkeley. Cohen and Louie have done an admirable job of guiding the reader gradually from elementary concepts to advanced topics. The book is divided into four main parts that have four chapters each. Chapter 1 presents models of solids in terms of interacting atoms, which is appropriate for the ground state, and excitations to describe collective effects. Chapter 2 deals with the properties of electrons in crystalline materials. The authors introduce the Born-Oppenheimer approximation and then proceed to the periodic potential approximation. Chapter 3 discusses energy bands in materials and covers concepts from the free electron model to the tight binding model and periodic boundary conditions. Chapter 4 starts with fixed atomic cores and introduces lattice vibrations, phonons, and the concept of density of states. By the end of this part, the student should have a basic understanding of electrons and phonons in materials. Part II presents electron dynamics and the response of materials to external probes. Chapter 5 covers the effective Hamiltonian approximation and the motion of the electron under a perturbation, such as an external field. The discussion moves to many-electron interactions and the exchange-correlation energy in Chapter 6, the widely-used Density Functional Theory (DFT) in chapter 7, and the dielectric response function in Chapter 8. The next two parts of the book cover advanced topics. Part III begins with a discussion of the response of materials to photons in Chapter 9. Chapter 10 goes into the details of electron-phonon interactions in different materials and introduces the polaron. Chapter 11 presents electron dynamics in a magnetic field and Chapter 12 discusses electrical and thermal transport in materials. Part IV takes the reader further into many body effects, superconductivity, and nanoscale materials. The authors introduce Feynman diagrams and many-body perturbation theory in Chapter 13, theories of superconductivity in Chapter 14, magnetism in Chapter 15, and low dimensional systems in Chapter 16. The first two parts are required reading for the beginner planning to perform DFT calculations. The advanced student interested in conducting research in condensed matter physics will benefit from continuing on to the last two parts. There is a set of problems at the end of each part. The narrative is aided by equations and detailed figures. References at the end of the book direct the reader to relevant books and review articles for each chapter. The inside covers include a periodic table and a useful list of fundamental physical constants. The authors present the underlying mathematics elegantly, which makes the textbook quite readable for those with a good mathematical background. Students lacking a firm footing in math will find the terrain rough after Chapter 1. This field has seen many good undergraduate textbooks including those by Kittel and by Ashcroft and Mermin. This volume fills the need for a rigorous graduate level textbook, and is a required addition to the bookshelf of every condensed matter physicist. Cohen and Louie have brought refreshing clarity to a challenging subject and made it eminently accessible to the motivated student.
... definition of BSIA should be avoided due to the dynamic nature of science. Therefore, as recommended by the... impact of this action on current Council peer review practices should be minimal because the peer review..., social and economic impacts of management measures, and sustainability of fishing practices.'' Id. 16 U.S...
... that he was using his relationship as a physician with a patient to divert medication for his own use... a corollary, [it] also bars doctors from peddling to patients who crave the drugs for those... units to patients'' and that he ``received half the dosage units back from the patients after the...
... fishery, including a requirement for independent, third-party dockside and at-sea monitoring of sector...; Approved Sector Monitoring Service Providers AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA), Commerce. ACTION: Notification of NMFS-approved sector...
Donahue, Mavis L.; Szymanski, Carol M.; Flores, Christine Wujek
Uses current research and theory to frame the peer interactions of "Emily Dickinson," a 16-year-old with oral-language problems and social isolation. Classroom-based assessment revealed an interaction pattern in which Emily used her strong literacy interests and skills to initiate and mediate social interaction with peers, including another gifted…
... state-operated permit banks for the purpose of maximizing the fishing opportunities made available by... activity to regain their DAS for that trip, providing another opportunity to profit from the DAS that would... entities. Further, no reductions in profit are expected for any small entities, so the profitability...
... envelope, ``Comments on MSB Amendment 14 NOA.'' Fax: (978) 281-9135, Attn: Aja Szumylo. Instructions... compromises the safety of the vessel, (2) mechanical failure prevents the catch from being brought aboard, or... slipping was safety or mechanical failure, would be required to return to port. This aspect of the measure...
... tagging, and model development to better evaluate the growth and reproductive performance of the... to initial logistical delays and additional time to complete research and funding components of this... study remain consistent with the Atlantic Deep-Sea Red Crab Fishery Management Plan. If approved, the...
... economic benefits, create individual economic stability, provide full utilization of the trawl sector... taken in the U.S. exclusive economic zone (EEZ) off the coasts of Washington, Oregon, and California... holistic alternatives relative to the biological and socio-economic environment and consistent with the...
... Research program. The primary objective of this study is to assess the effects of different stressors on... Reflex Action Mortality Predictors (RAMP) under different stressors to assess the discard mortality rates... research landings from the VTRs in their ACE accounting, in addition to the vessel's dealer-recorded...
lapsed ja lapsevanemad Austraaliast meenutavad oma viibimist Sõrve lastelaagris: This is a story of a family from Sõrve; Nicholas Wurm - Age 9 (Adelaide); Alan and Debbie Mikkor (Melbourne); Jesse Mikkor's point of view: Age 8; Lauren Mikkor's point of view: Age 13
... communities. The court upheld the integrated or holistic approach used to develop the harvest levels for all... Amendment 16-4. The Council, continuing the integrated or holistic approach developed in Amendment 16-4 and...:01-cv-00421-JLI. Review of recent catch levels as well as trends in the economic health of the...
..., including an adjustment to the overfishing definition, modification of the essential fish habitat (EFH... some IFQ separate from the vessel's LAGC permit; Revision of the essential fish habitat (EFH) closures...
..., including: A revision of the overfishing definition (OFD); modification of the essential fish habitat (EFH... by LAGC vessels as they continue to fish would count toward that stock area's sub-ACL for the scallop...: Fishing [[Page 19934
... stable trip limit approach for these fisheries will help provide consistency, safety, and predictability... available data. A stable trip limit approach will help provide consistency, safety, and predictability to... exceed, annual catch limits (ACLs) of target species; and to foster the rebuilding of overfished stocks...
... developed by the Council to modify the accountability measures for the Atlantic mackerel, Atlantic bluefish... mackerel, butterfish, Atlantic bluefish, summer flounder, scup, black sea bass, golden tilefish, ocean...
... Bluefish FMP; Amendment 2 to the Spiny Dogfish FMP; Amendment 15 to the Summer Flounder, Scup, and Black... developing ABC recommendations for the summer flounder, scup, and bluefish stocks. NMFS disagrees that the...
... amendment changes the accountability measures for the Atlantic mackerel, Atlantic bluefish, summer flounder... catch Atlantic mackerel, butterfish, Atlantic bluefish, summer flounder, scup, black sea bass, golden... bass and a single-year point estimate from MRIP for the Atlantic bluefish and mackerel fisheries...
... amendment proposes to change the accountability measures for the Atlantic mackerel, Atlantic bluefish... mackerel, butterfish, Atlantic bluefish, summer flounder, scup, black sea bass, golden tilefish, ocean.... (Note, Atlantic mackerel and bluefish currently use only a single-year comparison.) The Council also...
..., the Council decided to amend the Atlantic Mackerel, Squids, and Butterfish; Atlantic Bluefish; Spiny... Bluefish FMP; Amendment 2 to the Spiny Dogfish FMP; Amendment 15 to the Summer Flounder, Scup, and Black... subsequent fishing year. Atlantic Bluefish. The Council's proposed approach for bluefish would establish a...
Osawa, Takahito; Hatsukawa, Yuichi; Nagao, Keisuke; Koizumi, Mitsuo; Oshima, Masumi; Toh, Yosuke; Kimura, Atsushi; Furutaka, Kazuyoshi
The Cretaceous-Tertiary (K-T) boundary about 65 million years ago records a mass extinction event caused by a bolide impact. K-T boundary clay collected from Stevns Klint, Denmark was investigated in this work. Iridium concentrations of eight clays across the K-T boundary were determined using a multiple gamma-ray analysis system after neutron activation. Anomalously high Ir concentrations were detected in five marl samples, with the highest concentration being 29.9 ppb. Four samples were analyzed for all noble gases. NO extraterrestrial Ar, Kr, and Xe were discovered in any of the samples, although most of the 3 He which was detected was extraterrestrial. Solar-like Ne was observed only in the sample SK4, which had an Ir concentration of 14.3 ppb, indicating the presence of micrometeorites. The solar-like Ne clearly did not originate from an asteroid/comet associated with the bolide impact, as that asteroid is thought to have been extremely large. Also, because there was no sign of a high accretion rate of micrometeorites at the boundary it could not be ascertained whether the solar-like Ne was related to a catastrophic event that led to the extinction of the dinosaurs. (author)
... fishery is managed under an individual fishing quota system. In the mothership sector, catcher vessels deliver to floating processors called motherships. This fishery is managed under a single mothership co-op... fishermen opportunities to sustainably harvest over 90 species of groundfish managed under the FMP. Since...
The objectives of this study were to characterize volatile compounds and to determine the characteristic aromas associated with impact compounds in 4 fish sauces using solid-phase micro-extraction, gas chromatography-mass spectrometry, Osme, and gas chromatography olfactometry (SPME-Osme-GCO) couple...
Redalje, Susanne J.
For those unfamiliar with Star Trek, "Dunsel" was a term introduced in the episode titled "The Ultimate Computer." It is a term used by Star Fleet cadets to refer to an entity that serves no useful purpose, in this case a human who has been replaced by a machine. The episode touches on finding the best balance between human and machine to run a…
Sisu: Pühapäeva hommik ; Peter Quince klahvide ees ; Mozart, 1935 ; Postkaart vulkaanist ; Moodsast luulest ; Paks punane mees loeb ette ; Seesmise armukese viimane üksikõne ; Ühe üksikasja kulg. Elu- ja loomeloolisi andmeid autori kohta lk. 531-532
Autori hinnangul aja väärkasutajate probleem ei olegi niivõrd oskamatuses oma aega kasutada, vaid pigem vähene eneseusk ning alateadlik hirm, et tema tööle pannakse mingi hinnang. Neljast ajakasutaja tüübist. Kommenteerib psühhoterapeut Endel Talvik
Maria Elisa Montironi
Full Text Available This paper aims at describing the ways in which the Shakespeare myth is dealt with by The Simpsons, the worldwide successful American sit-com which since 1990 has depicted and reflected upon contemporary society, including its relation to and the institutionalization of literary canons, such as the Shakespearean one. In this investigation, The Simpsons will be considered as a trans-medial phenomenon, including, besides the celebrated sit-com, also the Simpsons based adaptation of Shakespeare’s Macbeth created and performed by Rick Miller (2002, the video games that feature the famous yellow-skinned characters, and the comic book series entitled Simpsons Comics. After a brief theoretical introduction, this paper will illustrate how the Shakespeare myth is de-mythologized through The Simpsons, to be re-mythologized so as to function and be meaningful in our contemporary world. In the conclusion, an attempt will be made to answer the extremely complex question about the political effectiveness of these acts.
... Information or otherwise sensitive or protected information. NMFS will accept anonymous comments (if... wish to remain anonymous). Attachments to electronic comments will be accepted in Microsoft Word, Excel... INFORMATION: Electronic Access This document is accessible via the Internet at the Office of the Federal...
Reviews a doctoral dissertation that attempts to identify and analyze the behavior of successful middle school music teachers. Describes the instrument developed to measure these behavioral characteristics. Suggests that the videotapes of class sessions may be the most useful portion of the study. (LS)
James Simmons began his career in the US Army as a laboratory officer and his assignments progressed into tropical medicine research. His interests and work evolved into preventive medicine (PM, as the Army termed public health), and he took both a PhD and a Doctorate in Public Health. As the Army's leading PM officer he was appointed head of PM in 1940 and guided the Army's PM effort through World War II. His responsibility ran from gas masks through healthy nutrition and occupational health to an enormous variety of diseases; by the war's end, the breadth and importance of PM was reflected in the Preventive Medicine Division, having fully one-sixth of all military personnel at the Surgeon General's Office. Simmons used his strong professional credentials to tap into civilian medicine for expertise the Army lacked and he established organizations that survive to this day. After retirement, he sought to expand the field of public health and raise another generation of public health physicians.
Puspa, Jessica; Handojo, Priska Febrinia
This study aims to understand the consequences that Josey Aimes and Erin Brockovich face in disobeying the patriarchal values in North Country and Erin Brockovich. Patriarchal society where Aimes and Brockovich live, demands that the roles of women are as domestic creatures. If they cannot accept their roles, as the consequences, they will be punished by the people who guard the patriarchal values. It can be seen that Aimes and Brockovich are still bound by the patriarchal values which inhibi...
.... MacDonald, Assistant Regional Counsel, U.S. Environmental Protection Agency, Region 10, 1200 Sixth Avenue, Suite 900, Seattle, Washington 98101; fax: (206) 553-1762; email: MacDonald[email protected] . FOR FURTHER INFORMATION CONTACT: Jennifer G. MacDonald, Assistant Regional Counsel, U.S. Environmental...
Mansbach, Steven, 1950-
Euroopa 20. saj. kunsti ajaloo õpetamisest Ameerikas. Pärast Teist maailmasõda Ameerikasse emigreerunud kunstiteadlaste tegevusest. Ignoreerivast suhtumisest Ida-Euroopa maade kunsti. Geograafiliste, ajaliste ja kultuuriliste eripärade ületamise vajadusest
The pollen assemblages of a core in the coniferhardwood formation in northwestern Minnesota are compared with the floristics of the recent vegetation in the region. Percentage levels of the main tree components have been compared first with those from recent surface samples taken at the same short
Church, Stan E.; Kirschner, Frederick E.; Choate, LaDonna M.; Lamothe, Paul J.; Budahn, James R.; Brown, Zoe Ann
Geochemical and radionuclide studies of sediment recovered from eight core sites in the Blue Creek flood plain and Blue Creek delta downstream in Lake Roosevelt provided a stratigraphic geochemical record of the contamination from uranium mining at the Midnite Mine. Sediment recovered from cores in a wetland immediately downstream from the mine site as well as from sediment catchments in Blue Creek and from cores in the delta in Blue Creek cove provided sufficient data to determine the premining geochemical background for the Midnite Mine tributary drainage. These data provide a geochemical background that includes material eroded from the Midnite Mine site prior to mine development. Premining geochemical background for the Blue Creek basin has also been determined using stream-sediment samples from parts of the Blue Creek, Oyachen Creek, and Sand Creek drainage basins not immediately impacted by mining. Sediment geochemistry showed that premining uranium concentrations in the Midnite Mine tributary immediately downstream of the mine site were strongly elevated relative to the crustal abundance of uranium (2.3 ppm). Cesium-137 (137Cs) data and public records of production at the Midnite Mine site provided age control to document timelines in the sediment from the core immediately downstream from the mine site. Mining at the Midnite Mine site on the Spokane Indian Reservation between 1956 and 1981 resulted in production of more than 10 million pounds of U3O8. Contamination of the sediment by uranium during the mining period is documented from the Midnite Mine along a small tributary to the confluence of Blue Creek, in Blue Creek, and into the Blue Creek delta. During the period of active mining (1956?1981), enrichment of base metals in the sediment of Blue Creek delta was elevated by as much as 4 times the concentration of those same metals prior to mining. Cadmium concentrations were elevated by a factor of 10 and uranium by factors of 16 to 55 times premining geochemical background determined upstream of the mine site. Postmining metal concentrations in sediment are lower than during the mining period, but remain elevated relative to premining geochemical background. Furthermore, the sediment composition of surface sediment in the Blue Creek delta is contaminated. Base-metal contamination by arsenic, cadmium, lead, and zinc in sediment in the delta in Blue Creek cove is dominated by suspended sediment from the Coeur d?Alene mining district. Uranium contamination in surface sediment in the delta of Blue Creek cove extends at least 500 meters downstream from the mouth of Blue Creek as defined by the 1,290-ft elevation boundary between lands administered by the National Park Service and the Spokane Indian Tribe. Comparisons of the premining geochemical background to sediment sampled during the period the mine was in operation, and to the sediment data from the postmining period, are used to delineate the extent of contaminated sediment in Blue Creek cove along the thalweg of Blue Creek into Lake Roosevelt. The extent of contamination out into Lake Roosevelt by mining remains open.
High Temperature Superconductors: From Delivery to Applications (Presentation from 2011 Ernest Orlando Lawrence Award-winner, Dr. Amit Goyal, and including introduction by Energy Secretary, Dr. Steven Chu)
Dr. Amit Goyal, a high temperature superconductivity (HTS) researcher at Oak Ridge National Laboratory, was named a 2011 winner of the Department of Energy's Ernest Orlando Lawrence Award honoring U.S. scientists and engineers for exceptional contributions in research and development supporting DOE and its mission. Winner of the award in the inaugural category of Energy Science and Innovation, Dr. Goyal was cited for his work in 'pioneering research and transformative contributions to the field of applied high temperature superconductivity, including fundamental materials science advances and technical innovations enabling large-scale applications of these novel materials.' Following his basic research in grain-to-grain supercurrent transport, Dr. Goyal focused his energy in transitioning this fundamental understanding into cutting-edge technologies. Under OE sponsorship, Dr. Goyal co-invented the Rolling Assisted Bi-Axially Textured Substrate technology (RABiTS) that is used as a substrate for second generation HTS wires. OE support also led to the invention of Structural Single Crystal Faceted Fiber Substrate (SSIFFS) and the 3-D Self Assembly of Nanodot Columns. These inventions and associated R and D resulted in 7 R and D 100 Awards including the 2010 R and D Magazine's Innovator of the Year Award, 3 Federal Laboratory Consortium Excellence in Technology Transfer National Awards, a DOE Energy100 Award and many others. As a world authority on HTS materials, Dr. Goyal has presented OE-sponsored results in more than 150 invited talks, co-authored more than 350 papers and is a fellow of 7 professional societies.
The purpose of the report is to present the results of a study done to determine (1) the monthly and annual water budgets and probable variation in runoff for the drainage basin in which the mine is located; (2) if precipitation is the source of low pH water found in pit 3 and the retention pond; (3) the quality of water in pits 3 and 4, the retention pond, streamflow from the basin, Blue Creek upstream and downstream of the point the drainage enters, and near the mouth of Blue Creek; (4) the quality of ground water discharged from the basin into Blue Creek; and (5) the daily mean values of discharge, water temperature, specific conductance, and pH for mine drainage from the basin, Blue Creek upstream and downstream of the mine drainage, and near the mouth of Blue Creek. The report also describes a potential water-quality monitoring program that would allow the determination of annual loads of selected chemical constituents entering Blue Creek from the mine basin and information about the type of ground-water tracers and procedures needed to examine flow paths near the retention pond
Artikkel analüüsib, kuidas eurooplased tajuvad sotsiaalset ühtekuuluvust, võttes sealjuures arvesse majandussurvet ja institutsionaalset usaldust. Aluseks on Eurobaromeetri uuring vaesusest ja sotsiaalsest tõrjutusest (2010), mis haaras 27 liikmesriiki (sh Eesti)
Meyers, Carol A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
This study provides a modern take on an age-old need: busy parents need extremely fast, high quality home-cooked dinners that their kids will eat. In the past decade, the number of choices that parents have for filling this need have proliferated, largely due to technological advances. Our study proposes to leverage this technology in building a system geared toward decreasing whining in kids and increasing the sanity of their parents.
... of the Magnuson-Stevens Act, or to meet overfishing and rebuilding requirements of the Magnuson... consistent with the national standards of the Magnuson-Stevens Act, or to meet overfishing and rebuilding...
... DEPARTMENT OF COMMERCE Performance Review Board Membership AGENCY: Economics and Statistics... the Performance Review Board (PRB) in accordance with the Economics and Statistics Administration's.... Bostic, Jr., Arnold A. Jackson, Theodore A. Johnson, Steven J. Jost, J. Steven Landefeld, Jennifer Madans...
National Oceanic and Atmospheric Administration, Department of Commerce — The Magnuson-Stevens Fishery Conservation and Management Act (Magnuson-Stevens Act) requires NOAA’s National Marine Fisheries Service (NMFS) to collect fees to...
Schein, Edgar H.
"Adapted from the text of the Sixteenth Annual Frederick J. Gaudet Lecture, sponsored by the Stevens Chapter of Psi Chi, The National Honor Society in Psychology, Stevens Institute, Hoboken, N.J., April 30, 1991"--P. 1.
... Prickett (NHGRI), and Steven Rosenberg (NCI). Publication: Prickett TD, et al. Exon capture analysis of G... Steven Rosenberg (NCI) Publication: Prickett TD, et al. Exon capture analysis of G-protein coupled... Steven Rosenberg (NCI) Publication: Cronin JC, et al. Frequent mutations in the MITF pathway in melanoma...
... Immunotherapy. For collaboration opportunities, please contact Steven A. Rosenberg, M.D., Ph.D. at [email protected], Richard A. Morgan, Steven A. Rosenberg (all of NCI). Intellectual Property: HHS Reference No. E-105-2012/0... contact Steven A. Rosenberg, M.D., Ph.D. at [email protected] . Antagonists of Hyaluronan Signaling for...
technology has changed history , Apollo lunar program made a staggering contribution to high tech development. Report No. SERC-2018-TR-106...Gregg Vesonder, Stevens Institute of Technology Co-Principal Investigator: Dr. Dinesh Verma, Stevens Institute of Technology Research Team...Stevens Institute of Technology : Dr. Nicole Hutchison, Mr. Sergio Luna, Mr. William Miller, Dr. Hoong Yan See Tao, Dr. Jon
... Renville Rice Sherburne Sibley Stearns Steele Stevens Swift Todd Traverse Wabasha Wadena Waseca Watonwan... Langlade Lincoln Marathon Marinette Menominee Oneida Pepin Portage Price Richland Rusk Shawano Taylor...
..., Tommy Beck, Richard Belin, Alletta Berrigan, Michael Black, Michael Black, Steven Blanchard, Mary Josie..., Robert Reidenbach, Dennis Reynolds, Michael Rice, Bryan Roberson, Edwin Rountree, Carl Russ, David...
National Aeronautics and Space Administration — Steven Winter Associates, Inc. (SWA) proposes to develop a nation-wide informal technology education program that integrates math, science, engineering and...
Surmahiirte tants; Pühapäeva hommik; Unistus venna külaskäigust; Kolm päeva voodipuhkust; Veepiir; Ei sugutunnuseid ega muid iseärasusi : [Luuletused] / Wallace Stevens ; inglise k. tlk. ja järelsõna: Andres Ehin
Autorist lk. 212. Luuletuste 'Unistus venna külaskäigust', 'Kolm päeva voodipuhkust', 'Veepiir' ja 'Ei sugutunnuseid ega muid iseärasusi', mis on samuti ekslikult sealsamas W. Stevensile omistatud, autor on tegelikult Carlos Stewal. Vt. Ehin, Andres. Veavabandus // Looming. 1995. Nr. 5. Lk. 718
The isotopic composition of ore lead of the Creede mining district and vicinity, San Juan Mountains, Colorado: Text of a talk presented at the San Juan Mountains symposium to honor Thomas A. Steven; Rocky Mountain Section meeting of the Geological Society of America, May 2, 1987, Boulder, Colorado
Foley, N.K.; Barton, P.B.; Bethke, P.M.; Doe, B.R.
Galenas from the major Creede veins and their northern extensions are remarkably homogeneous in Pb-isotopic composition and are too radiogenic to have been derived from any magma comparable in composition to the principal volcanic rocks. This pattern was identified by Doe et al. in 1979 who proposed that the lead was derived from the Precambrian basement. The homogeneity of the ore leads, however, requires a uniform reservoir; an unlikely prospect for lead from the Precambrian basement. We report on 16 new analyses of geographically and paragenetically dispersed galenas from the Creede district and other areas as far as 11 km to the north. The lead values range from 18.972 to 19.060 for 206Pb/204Pb, from 15.591 to 15.671 for 207Pb/204Pb, and from 37.781 to 37.921 for 208Pb/204Pb. These ranges overlap those previously reported for the main ore zone.
2003 (Fort Sill, OK: US Army Field Artillery Center, 2004), 62-63. 3 Sean Bateman and Steven Hady, “King of Battle Once Again: An Organizational...To What Ends Military Power?” International Security 4, no. 4 (Spring 1980): 3- 35. Bateman , Sean and Steven Hady. “King of Battle Once Again: An
The article analyzes the use of memory and history in Steven Spielberg's war films Schindler's List (1993), Saving Private Ryan (1998) og tv-serien Band of Brothers (2001)......The article analyzes the use of memory and history in Steven Spielberg's war films Schindler's List (1993), Saving Private Ryan (1998) og tv-serien Band of Brothers (2001)...
... Purpose and scope. Regulations in this part were developed by the Council under the Magnuson-Stevens... activities that will result in an ongoing, regionally based, fisheries-related economy. (f) Groundfish... measures. Regulations in this part were developed by NMFS and the Council under the Magnuson-Stevens Act...
... in advance through local media, newspapers and the BLM Web site at: http://www.blm.gov/ca/st/en/fo...: Casa Diablo IV Development Project, C/O Steven Nelson, Project Manager. Documents pertinent to this... National Forest, telephone (760) 873- 2424; or mail to: Steven Nelson, Project Manager, BLM [[Page 16807...
Berg, Steven; Burns, James MacGregor; McKay, Ritchie
This article presents a transcript of Steven Berg's interviews with James MacGregor Burns and Ritchie McKay regarding leadership. James Burns is a senior fellow in the Jepson School of Leadership Studies at the University of Richmond, Virginia. Ritchie McKay is Head Coach of the men's basketball team at University of New Mexico. Steven Berg is an…
Paul A. Volden, Erin L. Wonder, Maxwell N. Skor, Christopher M. Carmean, Honggang Ye, Masha Kocherginsky, Eleanor Smith, Steven Kregel, Martha K...Wonder, Maxwell N. Skor, Christopher M. Carmean, Honggang Ye, Masha Kocherginsky, Steven Kregel, Martha K. McClintock, Matthew J. Brady, and Suzanne
A Commentary on the heading article "The Philosophy and Semantics of the Cognitive Science of Religion" by Steven Engler and Mark Q. Gardiner......A Commentary on the heading article "The Philosophy and Semantics of the Cognitive Science of Religion" by Steven Engler and Mark Q. Gardiner...
Interactive Model-Centric Systems Engineering (IMCSE) Phase 5 Technical Report SERC-2018-TR-104 Feb 28, 2018 Principal Investigator...Date February 28, 2018 Copyright © 2018 Stevens Institute of Technology, Systems Engineering ...Research Center The Systems Engineering Research Center (SERC) is a federally funded University Affiliated Research Center managed by Stevens
... MD Steven Karceski, MD Stroke, tPA, and physician decision-making Dominic Hovsepian, BS Steven Karceski, MD WHAT DID ... has not been carefully studied is the physician ’ s decision-making process. It was because of this that Dr. ...
Rack Mount System Mechanical Drawing Package by Steven P Callaway Approved for public release; distribution unlimited...Laboratory White House Communications Agency (WHCA) Presidential Voice Communications Rack Mount System Mechanical Drawing Package by Steven P...Note 3. DATES COVERED (From - To) 04/2013 4. TITLE AND SUBTITLE White House Communications Agency (WHCA) Presidential Voice Communications Rack
Keystone Symposia kicked off the start of 2012 with two joint meetings on Epigenomics and Chromatin Dynamics and a star-studded list of speakers. Held in Keystone, CO, January 17-22, and organized by Steven Jacobsen and Steven Henikoff and by Bradley Cairns and Geneviève Almouzni, respectively...
...'Tonya Davis Sheryl Lard-Whiteford David Elder Murray Lumpkin Denise Esposito William Maisel Tracy Forfa... Steven Solomon Daniel McChesney Stephen Spielberg William McConagha Roberta Wagner Patrick McGarey David... Murphy Donald Zink Melinda Plaisier Lynne Rice Mark Roh James Sigg Steven Silverman Howard Sklamberg...
Directed by Steven Spielberg , Performed by Haley Joel Osment, Jude Law, William Hurt, Frances O’Connor and Sam Robards. 16 well-structured, and ill...Artificial Intelligence. Directed by Steven Spielberg . Performed by Haley Joel Osment, Jude Law, William Hurt, Frances O’Connor and Sam Robards
Steven Spielberg Vincent Price Buster Keaton Harry Ritz Robert Duvall (2) Results for Role-based Entity Clustering We validate our role-based entity...Connery Jeanette Macdonal d Robert Benchley 1 0 Vincent Price Steven Spielberg Vincent Price Buster Keaton Harry Ritz Robert Duvall
Stevens-Johnson syndrome is an adverse muco-cutaneous complication arising from a number of conditions which include the administration of some drugs. A female Nigerian with chronic lymphocytic leukaemia, (Binet stage C) who developed Stevens-Johnson syndrome following commencement of allopurinol is ...
PTSD study and the Steven and Alexandra Cohen Veterans Center for the Study for Post - Traumatic Stress Disorder ... Post - Traumatic Stress Disorder and Traumatic Brain Injury recruitment protocol. All subjects participating in an MRI scan are required to provide...include subjects from the Steven and Alexandra Cohen Veterans Center for the Study for Post - Traumatic Stress Disorder and Traumatic Brain Injury who
Agents and Multi- Agent Systems (AAMAS), Valencia, Spain, June 4-8, 2012. Steven Okamoto_, Praveen Paruchuri, Yonghong Wang, Katia Sycara, Janusz...Society, Santa Monica, CA: Human Factors and Ergonomics Society. 86. Steven Okamoto_, Praveen Paruchuri, Yonghong Wang, Katia Sycara, Janusz
Home; Journals; Resonance – Journal of Science Education. Prasad Perlekar. Articles written in Resonance – Journal of Science Education. Volume 21 Issue 5 May 2016 pp 395-400 General Article. Steven Vogel (1940-2015) · Prasad Perlekar Rajaram Nityananda · More Details Abstract Fulltext PDF. Steven Vogel was a ...
Steven A. Bank, Kirk J. Stark, and Joseph J. Thorndike provide a historical account of America’s war-time fiscal policies for the major American wars...accessed January 16, 2012). 63 Steven A. Bank, Kirk J. Stark, Joseph J. Thorndike , War and Taxes (Washington, DC: The Urban Institute Press, 2008
mice. Toxicol Sci 45(1): 33-41. Merdink, J.L., Stenner , R.D., Stevens, D.K., Parker, J.C. and Bull, R.J. 1999. Effect of enterohepatic circulation...Document RR-03-07. Stenner , R.D., Merdink, J.L., Stevens, D.K., Springer, D.L. and Bull, R.J. 1997. Enterohepatic recirculation of trichloroethanol...Pharmacol 123(1): 1-8. Templin, M.V., Stevens, D.K., Stenner , R.D., Bonate, P.L., Tuman, D. and Bull, R.J. 1995. Factors affecting species differences
The United States Institute of Peace, 2006. 35 Steven Kotler , “’Dark Web’ Project Takes on Cyber-Terrorism,” October 12, 2010, http...245 Gabriel, “Terror on the Internet: The New Arena, the New Challenge.” 246 Ibid., 218. 247 Steven Kotler , “’Dark...Washington Law School Pub. L. Research Paper No. 13, Harvard L. Rev. 119 (2005): 531. King v. U.S., 55 F.3rd 1193 (6th Cir. 1995). Kotler , Steven. “’Dark
Local Purchasing of Journals is Required in Addition to a Nationally Purchased Collection to Meet the Information Needs of NHS Staff. A review of: Glover, Steven William, John Addison, Colette Gleghorn, and John Bramwell. “Journal Usage in NHS Hospitals: A Comparison Report of Total Usage at an Acute NHS Trust and a Specialist NHS Trust in the North West of England.” Health Information and Libraries Journal 24.3 (2007: 193‐9.
Full Text Available Objective ‐ To compare journal usage between an acute National Health Service (NHS Trust and a specialist NHS Trust located in North West England to provide some evidence as to how well the National Core Content Collection (provided by ProQuest meets the needs of staff in these settings.Design ‐ Comparative studySetting ‐ An acute NHS Trust, comprising four hospital sites, and a cancer specialist NHS Trust based on a single site. Both Trusts are located in North West England. The cancer specialist NHS Trust is a teaching hospital with undergraduate nurses, medical students, and student radiographers. This Trust is also closely associated with an adjoining cancer research institute. The acute NHS Trust has a large number of healthcare staff in training and was not described as a teaching hospital.Subjects ‐ Staff of the respective NHS Trusts. The staff numbers for each organisation were not provided.Methods ‐ COUNTER usage statistics of online journals, obtained from publisher administration tools, were collected for one year covering the period 1 December 2005 to 30 November 2006. Where available, the number of photocopies made from print journals during the same period by library users for their own use was also included. All full‐text downloads of journal articles were counted as part of this study, hence the possibility of double counting if a single article was requested in both HTML and PDF versions. Details of free or open access articles accessed without the need for a username and password were not included in the study. To encourage use of the electronic journals, library services at both Trusts implemented a number of initiatives to maximize publicity. These included direct e‐mails to staff, posters, and presentations to staff. Athens registration, required for access to the electronic journal collections, was promoted as part of the induction process for new library users. Staff members were encouraged to apply for the electronic table of contents alert for journals in their area of specialty. An A‐Z list of journals was accessible via the Trusts’ intranet and internet sites, and direct links to electronic journals were added to the NHS Dialog/Datastar databases and on PubMed.Main results ‐ The libraries at both Trusts in the study provide the majority of their journals in electronic‐only format. In addition to the National Core Content titles, the cancer specialist Trust provides access to an additional five journal collections: Science Direct Health Sciences, Blackwell Synergy Medical and Nursing collection, five journals selected from Nature Publishing Group, selected society journals via HighWire Press and Oxford University Press titles. Staff members of the acute Trust have access to an additional three journal collections: Science Direct Health Sciences, the BMJ Publishing Group (BMJPG collection and 16 LWW titles via Ovid. During the study period, a total of 93,376 articles were downloaded or copied. Of these, 47,079 articles were downloaded or copied by staff of the cancer specialist NHS Trust and 46,297 articles were downloaded or copied by staff of the acute NHS Trust. The usage of each of the journal collections during the study period for each Trust is shown in the table below with the most used resource shown in bold. (See article for table General information regarding some of the commonly used journal titles by staff of each Trust was included in the commentary, but levels of use were not enumerated. Staff of the cancer specialist NHS Trust favoured cancer‐related titles, whilst staff of the acute NHS Trust accessed journal titles over a greater range of subject areas. Details of the top titles accessed from the National Core Content collection were not provided for either Trust. A possible reason given for the lower usage level of the National Core Content collection by the cancer specialist NHS Trust compared to the acute NHS Trust was the presence of embargoes on many cancer‐related titles within the National Core Content collection. Information about training offered to staff, their level of access to computer facilities,or familiarity with accessing electronic journal collections was not provided.Conclusion ‐ Staff of both Trusts in the study recorded a high level of journal use, with a total of 93,376 articles downloaded or photocopied during the study period. There was a marked difference in the usage patterns of the National Core Content journals between the two Trusts studied with the acute NHS Trust showing a higher proportion of usage (29.9%compared with the cancer specialist Trust(4.5%. Staff members of the acute NHS Trust accessed a greater range of subject areas, while staff those at the cancer specialist NHS Trust favoured cancer related titles.The results indicated that the National Core Content collection did not meet the information needs of the specialist cancer Trust as well as it met the needs of the more generalist acute Trust. The National Core Content collection appears insufficient to meet the diverse information needs of all NHS staff. Local purchasing of journals, in addition to national level provision, is therefore required to ensure that the needs of local specialties are adequately supported.
Laasik, Andres, 1960-2016
Inglise näitleja Steven Dykesi näidend "Kolonistid" Londoni Bridge Lane Theatre laval. Näidend on inspireeritud A. Tshehhovi "Kolmest õest" ja tegevus toimub Eestis, tegelased on siinsed venelased
USA majandusajakirja BusinessWeek poolt läbi viidud uuringu andmetel olid 2004. aasta parimad juhid Jeffrey Immelt (General Electric) ja Steven Reinemund (PepsiCo) ning halvimad juhid Raymond Gilmartin (Merck) ja Michael Eisner (Walt Disney)
Ermel, Aare, 1957-2013
Kolmest iseseisvast armastusloost koosnev episoodfilm "Eros" : režissöörid Wong Kar-Wai ("Käsi"), Steven Soderbergh ("Tasakaal" / "Equilibrium"), Michelangelo Antonioni ("Asjade ohtlik käik") : Hongkong - Hiina - USA - Prantsuse - Itaalia 2004
Priimägi, Tristan, 1976-
Heliplaatidest: Iron & Wine "Our Endless Numbered Days", Sufjan Stevens "Seven Swans", Joanna Newsom "The Milk-Eyed Mender", Nick Drake "Made to Love Magic", Kings Of Convenience "Riot On an Empty Street", White Magic "Through the Sun Door"
... 31 (45-ST-31), one-quarter of a mile above the Gifford-Inchelium ferry landing, in Stevens County, WA... deformation, and structural remnants found at the sites (pit and earth ovens), it is determined that the human...
... your own well-being, which is another important value to model for your children. Reviewed by: Steven Dowshen, ... Your Child Tolerance Teaching Your Child Self-Control Disciplining Your Child ...
Rootsi disainer Steven Stahlberg on modelliagentuurile "Elite" loonud esimese virtuaalmodelli Webbie Tookay. Virtuaalmodellide tulevikust. Kommenteerivad "Elite Illusion 2K" direktor R. Bellino, briti moefotograaf N. Knight, moeajaloolane C. McDowell.
... been out exploring the woods, you might want to give your pet a shower, too! Reviewed by: Steven Dowshen, MD Date reviewed: February ... Visit the Nemours Web site. Note: All information on KidsHealth® is for ...
Uuest heliplaadist "Pärt: Berliner Messe. The Beatitudes. Annum per Annum. Magnificat. Seven Magnificat Antiphons. De profundis. Polyphony / Steven Layton with Andrew Lucas" Hyperion CDA66960 (74 minutes:DDD)
... Overview of Gallbladder Cancer Additional Content Medical News Portal Hypertension By Steven K. Herrine, MD, Professor of Medicine, ... Liver Hepatic Encephalopathy Jaundice in Adults Liver Failure Portal Hypertension Portal hypertension is abnormally high blood pressure in ...
... how to let things go.” “We can find support groups for people who hoard.” “We can ask the ... of neural activity during response inhibition. Tolin DF, Witt ST, Stevens MC. Psychiatry Res . ...
... still protecting skates from overfishing. DATES: Effective November 28, 2011, through April 30, 2012... conservation concerns (e.g., overfishing), and Magnuson-Stevens Act emergency actions have been used in the...
Venville, Grady; Milne, Catherine
Draws on an array of historical documents to delve into the history of genetics and the lives and scientific accomplishments of female geneticists that include Nettie Stevens, Rosalind Franklin, and Barbara McClintock. (Contains 20 references.) (Author/WRM)
... C. Spencer, MD Steven Karceski, MD The placebo effect Joseph H. Friedman, MD Richard Dubinsky, MD WHAT ... placebo: a “dummy” medication that should have no effect on the condition. Placebos are not only drugs. ...
Dr Steven Weinberg, in 1977, heard a rumor that collisions were spitting out weird triplets of particles known as muons, which are sor of fat electrons. He tried to concoct a theory to explain the trimuons. (1 page)
Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008
Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008. Indiana Jonesi tähestik
Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008
Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008
Tuch, Boris, 1946-
Sarapik, Rivo, 1981-
22 mail esilinastub Steven Spielbergi järjekordne Indiana Jones'i film, kaasstsenaristiks ja produtsendiks George Lucas ja Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull")
22 mail esilinastub Steven Spielbergi järjekordne Indiana Jones'i film, kaasstsenaristiks ja produtsendiks George Lucas ja Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull")
Ruben, Aarne, 1971-
Laasik, Andres, 1960-2016
Poliitiliselt tundlikud Hollywoodi uued mängufilmid - George Clooney "Head õhtut ja õnn kaasa" ("Good Night, and Good Luck"), Steven Spielbergi "München" ("Munich") ja Ang Lee "Brokebacki mägi" ("Brokeback Mountain")
Soukup, W.G.; Gillies, D.C.; Myette, C.F.
The surf icial sands in the Pomme de Terre and Chippewa River valleys in Grant, Pope, Stevens, and Swift Counties have been studied to determine the occurrence, availability, and quality of ground water in these aquifers.
Horsten, Hans-Henrik; Kemp, Michael; Fischer, Thea K
, vasculitis, syphilis, dermatophytid, erythema multiforme and Stevens-Johnson syndrome. Three adults and 3 children required hospitalization due to extensive skin involvement and fever. All reported patients had laboratory confirmed enterovirus infection. This study demonstrated an upsurge in atypical HFMD...
... Health Information Technology: Revisions to Initial Set of Standards, Implementation Specifications, and... Health Information Technology (ONC), Department of Health and Human Services. ACTION: Interim final rule... Coordinator for Health Information Technology, Attention: Steven Posnack, Hubert H. Humphrey Building, Suite...
Tuumalu, Tiit, 1971-
Inglise originaalist tõlgitud ligi 1000-leheküljeline teatmeteos "1001 filmi, mida elu jooksul peab nägema" (toimetaja Steven Jay Schneider). Artiklile lisatud filmikriitikute Jaan Ruusi ja Lauri Kärgi kommentaarid
..., 75 FR 81565 (December 28, 2010). \\3\\ Certain Oil Country Tubular Goods from the People's Republic of..., from Steven Hampton, International Trade Analyst, ``Certain Hot-Rolled Carbon Steel Flat Products from...
Research Priorities for NCI’s Center for Global Health' and included presentations on our mission, objectives, currently funded programs, and future programs given by Dr. Lisa Stevens and Paul Pearlman, as well as three special presentations by NCI grantees.
for Prevention Policy Member Rear Admiral Stephen Metruck Assistant Commandant for Resources, Chief Financial Officer Member Rear Admiral Steven...R. Grawe (Acting) Director of National Pollution Funds Center Member Mr. Gary C. Rasicot Director of Marine Transportation Systems Management
Environ Planning Design, 1970
Floor plans and photographs illustrate a description of the Samuel C. Williams Library at Stevens Institute of Technology, Hoboken, N.J. The unusual interior design allows students to take full advantage of the library's resources. (JW)
... Nicollet Olmsted Pope Redwood Renville Rice Sherburne Sibley Stearns Steele Stevens Swift Todd Traverse... Shawano Taylor Vernon Vilas Waupaca Wood * * * * * [FR Doc. 2012-30805 Filed 12-20-12; 8:45 am] BILLING...
Sobolev, Mari, 1968-
Jaan Toomiku ja Paul Rodgersi organiseeritud tegevuskunsti festivalist "Viinistu 2004", kavas performance'id, installatsioonid, video, näitused. Pikemalt Steven Coheni, Elu, Neeme Külma, Minna Hindi, Erik Alalooga esinemisest
Hallas-Murula, Karin, 1957-
2004. a. Rovaniemis läbiviidavast rahvusvahelisest jää- ja lumearhitektuuri üritusest, kuraator Lance Fung. Steven Holli jääplokkidest kuup - projekti pilootehitis. Osalevate arhitektide ja kunstnike osaline loetelu
Festivalist, mis toimub loosungi all "Towards tolerance" ja võistluskava filmidest : briti režissööri Michael Winterbottomi "Siin maailmas", sakslase Wolfgang Beckeri absurdikomöödia "Jumalaga, Lenin!" ning Steven Soderberghi "Solaris"
... techniques or other forms of information technology. Comments may be sent to: Steven Carlson, Director... States will receive remuneration of $75,000 to offset the costs of participating in the study. Interview...
National Aeronautics and Space Administration — DATA MINING THE GALAXY ZOO MERGERS STEVEN BAEHR, ARUN VEDACHALAM, KIRK BORNE, AND DANIEL SPONSELLER Abstract. Collisions between pairs of galaxies usually end in the...
Sisu: six six six paradox ; cat stevens ; "vahel tundub, et mu ümber..." ; sääse ; Salaalaealised ; kolkalapsed ; longin mööda lumiseid tänavaid ; punkrock dekadents ; "Igast kirjaneitsist..." ; "mina olengi see saikochick..."
..., mechanical, or other technological collection techniques or other forms of information technology. Comments... be directed to Steven Carlson at 703-305-2017. SUPPLEMENTARY INFORMATION: Title: National School... DEPARTMENT OF AGRICULTURE Food and Nutrition Service Agency Information Collection Activities...
... may have an infection such as TRENCH MOUTH, GINGIVITIS or PERIODONTITIS. A rare drug reaction, STEVENS-JOHNSON ... Control Family Health Infants and Toddlers Kids and Teens Pregnancy and Childbirth Women Men Seniors Your Health ...
Prevalence, risk factors and risk perception of tuberculosis infection among medical students and healthcare workers in Johannesburg, South Africa. A van Rie, K McCarthy, L Scott, A Dow, WDF Venter, WS Stevens ...
The crew (Commander Eileen M. Collins, Pilot Jeffrey S. Ashby, Mission Specialists Steven A. Hawley, Catherine G. Coleman, and Michael Tognini) are dressed in cleanroom suits while overseeing the solar panel installation.
... D. Bennett, Johnny W. Bradford Sr., Levi A. Brown, Charlie F. Cook, Clifford H. Dovel, Arthur L..., Steven L. Valley, Thomas E. Voyles, Jr., Darel G. Wagner, Bernard J. Wood. These exemptions are extended...
..., Sr., Levi A. Brown, Charlie F. Cook, Clifford H. Dovel, Arthur L. Fields, John W. Forgy, Glenn E. Gee..., Monte L. Purciful, Luis F. Saavedra, Earl W. Sheets, Robert V. Sloan, Steven L. Valley, Thomas E. Voyles...
... A. Lawson (KY) Everett H. Logan (OH) Joseph L. Mast (OR) Jesse R. McClary, Sr. (MO) Kevin L. Moody.... Huelster (OK) Roger D. Kloss (IL) Mark D. Kraft (IL) Steven R. Lechtenberg (NE) Thomas W. Markham (MN) Paul...
... Individual), Steven L. Leturno, Director, Application Type: QI Change. Combined Freight System, Inc. (NVO...), 148-08 Guy R. Brewer Blvd., Jamaica, NY 11434, Officers: Wei Hu, Vice President, (Qualifying...
... Editors David C. Spencer, MD Steven Karceski, MD Multiple sclerosis and vitamin D Andrew J. Solomon, MD WHAT ... caused by improper immune responses (autoimmune diseases), including multiple sclerosis (MS). A recent Patient Page in Neurology provided ...
... James C. Askin, Paul J. Bannon, Ernie E. Black, Ronnie F. Bowman, Gary O. Brady, Stephen H. Goldcamp, Steven F. Grass, Wai F. King, Dennis E. Krone, Richard J. McKenzie, Jr., Christopher J. Meerten, Craig W...
.... Askin, Paul J. Bannon, Ernie E. Black, Ronnie F. Bowman, Gary O. Brady, Stephen H. Goldcamp, Steven F. Grass, Wai F. King, Dennis E. Krone, Richard J. McKenzie, Jr., Christopher J. Meerten, Craig W. Miller...
..., Duane C. Jackson, John J. Long, Jerry A. McMurdy, Steven L. Miller, Joe E. Montoya, Jonathan A. Morisoli.... Tomasik, Leonard D. Tournear, Booker T. Ware and Joseph H. Watkins, from the ITDM standard in 49 CFR 391...
Nestor, Siim, 1974-
Lauludest: Sufjan Stevens "Come On! Let's Boogey to the Elf dance", Frank Sinatra "Whatever Happened to Christmas?", Vaiko Eplik ja Eliit "Kas usud sinagi", Panda Bear "Bros", Prince "Another Lonely Christmas"
... intended to enter commerce or enter commerce through sale, barter, or trade. All lobster fishing in... under the Magnuson-Stevens Act. Vessel monitoring system unit (VMS unit) means the hardware and software...
... (FPA), proposing to study the feasibility of the Microturbine Hydrokinetic River-In-Stream Energy.... Applicant Contact: Mr. Steven M. Selvaggio, Whitestone Power and Communications, P.O. Box 1630, Delta...
Beecher, David Ilmar
Lastekirjandusest teadusliku allikana ning Maurice Sendaci lasteraamatust "Where the wild things are" (1964) ja Steven Kelloggi lasteraamatust "The island of the Skog" (1976). Tekst põhineb "Õnnekonverentsi" ettekandel, mis peeti 3. mail 2011. aastal
Priimägi, Tristan, 1976-
Tristan Priimägi kohtumisest Londoni klubis Hard Rock Cafe ameerika rockansambli Aerosmith liikmetega, intervjuu Steven Tyleriga. Heliplaatidest "Aerosmith", "Toys in the Attic", Run D.M.C & Aerosmith "Walk This Way", Get a Grip"
Laaniste, Mari, 1977-
Mängufilm "Karusnahk: Diane Arbuse kujutletav portree" ("Fur: An Imaginary Portrait of Diane Arbuse") : stsenarist Erin Cressida Wilson : režissöör Steven Shainberg : nimiosas Nicole Kidman : Ameerika Ühendriigid 2006
... Christopher W. Bailey (OH), Kent S. Bills (IN), Bobby B. Brown (VA), Maryland A. Chandler (KY), Ronald D. Clark (AR), Larry L. Eberly (PA), Steven J. Fessler (IL), Michael R. Fisher (IA), Mark A. Krause (PA...
... Chief Steven A. Hady, Designated Federal Officer, MLDC, at (703) 602-0838, 1851 South Bell Street, Suite 532, Arlington, VA, E-mail [email protected] . Dated: February 16, 2010. Mitchell S. Bryman...
... TJ, Vreeburg M, Rouhl RPW, Stevens SJC, Stegmann APA, Schieving J, Pfundt R, van Dijk K, Smeets ... article on PubMed Central More from Genetics Home Reference Bulletins Genetics Home Reference Celebrates Its 15th Anniversary ...
... David C. Spencer, MD Steven Karceski, MD Mild cognitive impairment and progression to dementia New findings John C.S. ... exami- nations showed that 534 persons had mild cognitive impairment, or MCI (see About MCI, following sec- tion). ...
From left to right, sitting: Elena Shaposhnikova, Thomas Bohl, Gianluigi Arduini, and standing: Klaus Hanke, Trevor Linnecar, Rende Steerenberg, Michel Chanel, Roland Garoby, Elias Métral. Not pictured: Steven Hancock and Bernard Vandorpe.
Ecological periodic tables for nekton and benthic macrofaunal community usage of estuarine habitats Steven P. Ferraro, U.S. Environmental Protection Agency, Newport, OR Background/Questions/Methods The chemical periodic table, the Linnaean system of classification, and the Her...
Ulmeline seiklusfilm "Hüppaja" ("Jumper") Steven Gould'i teoste põhjal : stsenaristid David Goyer, Simon Kinberg, Jim Uhls : režissöör Doug Liman : peaosas Hayden Christensen : Ameerika Ühendriigid 2008
Ulmeline seiklusfilm "Hüppaja" ("Jumper") Steven Gould'i teoste põhjal : stsenaristid David Goyer, Simon Kinberg, Jim Uhls : režissöör Doug Liman : peaosas Hayden Christensen : Ameerika Ühendriigid 2008
..., search, seizure, or disposition of seized property in connection with enforcement of the Magnuson-Stevens..., due to the Deepwater Horizon oil spill. [60 FR 13919, Mar. 15, 1995, as amended at 67 FR 47469, July...
Appropriate tools and methods for tropical microepidemiology: a case-study of malaria clustering in Ethiopia. Tedros A Ghebreyesus, Peter Byass, Karen H Witten, Asfaw Getachew, Mitiku Haile, Mekonnen Yohannes, Steven W Lindsay ...
Pavel Tshuhrai USA televisiooni miniseriaalile tehtud dokumentaalfilm holokaustist "Sügaviku lapsed" ("Children from the Abyss"/"Deti iz bezdnõ"), mille tellis Steven Spielbergi asutatud fond "Shoa"
... Management Act (Magnuson-Stevens Act) and the Atlantic Tunas Convention Act (ATCA). Under the Magnuson... August 28, 2013, 6 San Antonio, TX.... Hilton Palacio Del Rio, 200 S. with the Gulf of Mexico Fishery p.m...
Bachmann, Karin, 1976-
Eesti Kunstiakadeemia X Urbanistika ja linnamaastike päevad "Between Architecture of War and Military Urbanism" ("Sõjaarhitektuuri ja militaarurbanistika vahel") 25.-28. aprillil 2013. a. Telliskivi Loomelinnakus Tallinnas. Konverentsi peaesinejad Stephen Graham ja Steven Flusty
... Development Infections Diseases & Conditions Pregnancy & Baby Nutrition & Fitness Emotions & Behavior School & Family Life First Aid & Safety Doctors & ... avoid sunburn . If your child tends to get eczema flare-ups, avoid harsh soaps. Reviewed by: Steven ...
Plaatselijke verdovingsmiddelen zetten een mechanisme in gang waarbij zenuwcellen zichzelf vernietigen. Dit kan leiden tot zenuwschade. Stevens wilde achterhalen hoe die zenuwschade ontstaat. Hij toont aan dat alle gangbare plaatselijke verdovingsmiddelen een soort zelfmoordmechanisme van
... to essential fish habitat covered by the Magnuson-Stevens Act are expected. There are no impacts to... Elimination System permit are needed. No effects on the aquatic or terrestrial habitat in the vicinity or the...
... the General Counsel, or Steven Kane, Consultant, 202-418-5911, [email protected] , Office of the Chief...., letter dated July 1, 2011, from R. Michael Sweeney, Jr., Hunton & Williams, on behalf of the Working...
...-Scott Rodino Antitrust Improvements Act of 1976, requires persons contemplating certain mergers or... status Party name 30-JUN-10 20100840 G Li & Fung Limited. G Steven Kahn. G The Max Leather Group, Inc. G...
... Drive, St. Thomas, U.S. Virgin Islands. FOR FURTHER INFORMATION CONTACT: Caribbean Fishery Management... contained in this agenda may come before this group for discussion, in accordance with the Magnuson- Stevens...
.... Applicant: Steven D. Emslie, Department of Biology and Marine Biology, University of North Carolina... bone concentrations, rich vegetation). These sites will be sampled by placing a test pit, no more than...
steel . Successful martempering requires a cooling rate sufficient to avoid the nose of the C- curve and thus prevent significant bainite formation. When...STUDY OF THE EFFECT OF INTERRUPTED QUENCHES ON A THERMONECHANICALLY PROCESSED HIGH CARBON STEEL by Steven A. Barton October 1982 Thesis Advisor: T.R...unlimited. A Study of the Effect of Interrupted Quenches on a Thermomechanically Processed High Carbon Steel by Steven A. Barton Lieutenant, United
Clarke Gray, Brenna
'Captain America, Masculinity, and Violence: The Evolution of a National Icon', by J. Richard Stevens, Syracuse University Press, 376 pages, 6 . 9, 2015, ISBN 978-0-8156-3395-2; ebook 978-0-8156-5320-2 This article favourably reviews' Captain America, Masculinity, and Violence: The Evolution of a National Icon' (Stevens 2015) and offers some suggestions for further research. The review explores the ways in which the book offers insights into one of the most popular characters in comics and a...
protected. Organizational theory has identified actions that organizations normally pursue or avoid in order to increase—or at least preserve—their...thesis. See note 1 for details. 85 179. Jeffrey W. Taliaferro, Steven E. Lobell, and Norrin M. Ripsman, “Introduction: Neoclassical Realism, the State...and For- eign Policy,” in Steven E. Lobell, Norrin M. Ripsman and Jeffrey W. Taliaferro, eds., Neoclassical Realism, the State, and Foreign Poli- cy
source of dangerous and confused policy guidance. Pifer, Steven, Richard C. Bush, Vanda Felbab- Brown , Martin S. Indyk, Michael O’Hanlon and Kenneth M...Japanese hedging option, while progressives, including Gareth Evans, are committed to global reductions of nuclear weapons. South Korea is primarily...September 2009. http://www.mda.mil/global/documents/pdf/paa.pdf Pifer, Steven, Richard C. Bush, Vanda Felbab- Brown , Martin S. Indyk, Michael E
34MISCELLANEOUS" ACCOUNT CATEGORY WITHIN THE DOD INSTRUCTION 7220.29-H DEPOT LEVEL MAINTENANCE COST ACCOUNTING SYSTEM by a. Steven Eugene Lehr CDecember 1984...PERFORMING ONG. REPORT NUMBER Maintenance Cost Accounting System 7. AUTHOR(&) S. CONTRACT OR GRANT NUMBER(@) Steven Eugene Lehr 9. PERFORMING ORGANIZATION...Availability Codes IS. KEY WORDS (Continue on reverse *ids It necessary and Identify by block number) Dvi Special Uniform Cost Accounting System DoD
Ulrich, Karl T., and Steven D. Eppinger. 2012. Product Design and Development, 5th ed. New York: McGraw-Hill Irwin. Warner, Jamie H., Franziska Schaffel...of tasks that an organization or business generally follows to transform a thought or idea of a product to a manufactured good. In the early stages...established product design and development processes. Karl Ulrich and Steven Eppinger (2012) state that one of the initial steps in the opportunity
En introduktion til Hollywoodbloggen på videnskab.dk med første indlæg om hollywoodfilmens alsidighed fra Van Damme til Schindler's List af Steven Spielberg Udgivelsesdato: 27 januar......En introduktion til Hollywoodbloggen på videnskab.dk med første indlæg om hollywoodfilmens alsidighed fra Van Damme til Schindler's List af Steven Spielberg Udgivelsesdato: 27 januar...
Pedersen, Peter Ole
Filmhistorisk artikel om fremstillingen af overvågning i science fiction-genren fra 1920 og frem til nutidige værker som bl.a. Steven Spielbergs Minority Report og George Lucas nyklassiker THX 1138......Filmhistorisk artikel om fremstillingen af overvågning i science fiction-genren fra 1920 og frem til nutidige værker som bl.a. Steven Spielbergs Minority Report og George Lucas nyklassiker THX 1138...
49 Derek Scissors and Steven Bucci. “China Cyber Threat: Huawei and American Policy Toward Chinese Companies.” The...Heritage Foundation, no. 3761, October 23, 2012, http://www.heritage.org/research/reports/2012/10/china-cyber-threat- huawei -and-american-policy-toward...try- to-avoid-a-cold-war-mentality.html?pagewanted=all. 113 Scissors, Derek, and Steven Bucci. “China Cyber Threat: Huawei and American Policy
Isolated Ion- Pair 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide Emmanuel I. Obi†, Christopher M. Leavitt†, Paul L. Raston... Christopher P. Moradi†, Steven D. Flynn†, Jerry A. Boatz§,*, Steven D. Chambreau‡,* and Gary E. Douberly†,* †Department of Chemistry, University of...Windus, T. L.; Dupuis , M.; Montgomery, J. A. General Atomic and Molecular Electronic-Structure System. J. Comput. Chem. 1993, 14, 1347-1363
digital animation industry, which is drawing audiences around the world, and profits for the U.S. entertainment sector. Leonard explained to attendees... audiences in large part because a range of HPC hardware and software tools enabled filmmakers to control subtle aspects of lighting to characters’ fur and...Blackstone Group Harold J. Raveché Stevens Institute of Technology Steven S Reinemund Pepsi -Cola Company Judith Rodin University of Pennsylvania Allen B
Full Text Available Granqvist, Raoul, editor. Canonization and Teaching of African Literature. Matatu 7 by Claire L. Dehon Margolis, Joseph. Texts Without Referents: Reconciling Science and Narrative by David J. Depew Keitel, Evelyne. Reading Psychosis, Readers, Texts and psychoanalysis by Reinhild Steingrover Shaviro, Steven. Passion and excess: Blanchot, Bataille, and Literary Theory by Steven Ungar Kellner, Douglas. Jean Baudrillard From Marxism to Postmodernism and Beyond by Allan Stoeld Pecorora, Vincent P. Self & Form in Modern Narrative by Walter A. Strauss Jordan, Barry. Writers and Politics in Franco's Spain by Salvador J. Fajardo Motard-Noar, Martine. Les Fictions d'Hélène Cixous. Une autre lanque de femme by Randi Brox Birn Alexandrov, Vladimir E. Nabokov's Otherworld by Dale E. Peterson Baker, Peter. Obdurate Brilliance: Exteriority and the Modern Long Poem by Steven Winspur
Positioning System by Ma, Wei-Ming September 1988 Co-Advisor: Kandiah Jeyapalan Co-Advisor: Stevens P. Tucker Approved for public release; distribution is... Jeyapalan and Stevens P. Tucker, my thesis advisors, for their dedicated assistance and guidance during the study. Without their encouragement...method of collocation is [ Jeyapalan , 1977]: x = A*X+S +n +O.S q q P where x the vector of the observation (x = Ah - N0(X,Y,Z) - H) A a given rectangular
Grein, M.E., Elgin, L.E., Robinson, B.S., Kachelmyer, A.L., Caplan , D.O., Stevens, M.L., Carney, J.J., Hamilton, S.A., and Boroson, D.M., “Demonstration...Robinson, B.S., Kerman, A.J., Dauler, E.A., Barron, R.J., Caplan , D.O., Stevens, M.L., Carney, J.J., Hamilton, S.A., Yang, J.K.W., and Berggren, K.K., “781...Mbit/s photon-counting optical communications using a superconducting nanowire detector,” Optics Letters, v. 31 no. 4 444-446 (2006).  Caplan
8217VPaoli, molyore, ’leming# Daily, Otis, AKrun, Brus , LcKley, "ray, Jos, Id~lia, and Vernon. Thjen tncrc are a nuuber ul CceUCeerleS in tebween witl Ourialz...KS Public Comments VI - 5-101 Grace Eastin Yuma, CO M. H. Eaton Oakley, KS Mr. Dan R. Ebener Dubuque, IA Mr. Tom Eberhart Burlington, CO Elizabeth ...Russell Springs, KS Burlington, CO Rebecca L. Smith Mrs. Elizabeth StevensWinona, KS Potter, NE * r. Ronald L. Smith Mr. Wesley L. Stevens Winona, KS
Pedersen, Peter Ole
Filmbog med hovedfokus på temaet overvågning i thriller og science fiction-genren. Gennem omfattende analyser af Francis Ford Coppolas The Conversation (1974), David Finchers Panic Room (2002), George Lucas THX 1138 (1971) og Steven Spielbergs Minority Report (2002) gives kritisk bud på populærfi......Filmbog med hovedfokus på temaet overvågning i thriller og science fiction-genren. Gennem omfattende analyser af Francis Ford Coppolas The Conversation (1974), David Finchers Panic Room (2002), George Lucas THX 1138 (1971) og Steven Spielbergs Minority Report (2002) gives kritisk bud på...
Brenna Clarke Gray
Full Text Available 'Captain America, Masculinity, and Violence: The Evolution of a National Icon', by J. Richard Stevens, Syracuse University Press, 376 pages, 6 . 9, 2015, ISBN 978-0-8156-3395-2; ebook 978-0-8156-5320-2 This article favourably reviews' Captain America, Masculinity, and Violence: The Evolution of a National Icon' (Stevens 2015 and offers some suggestions for further research. The review explores the ways in which the book offers insights into one of the most popular characters in comics and also gestures towards the work scholars of mainstream American superhero comics must tackle in the future.
Full Text Available Tree Search Steven James∗, George Konidaris† & Benjamin Rosman∗‡ ∗University of the Witwatersrand, Johannesburg, South Africa †Brown University, Providence RI 02912, USA ‡Council for Scientific and Industrial Research, Pretoria, South Africa steven....email@example.com, firstname.lastname@example.org, email@example.com Abstract Monte Carlo Tree Search (MCTS) is a family of directed search algorithms that has gained widespread attention in re- cent years. Despite the vast amount of research into MCTS, the effect of modifications...
..., to the extent practicable, adverse social and economic effects. The Magnuson-Stevens Act provides the...-hire harvest. Producer surplus represents profit in the for- hire sector. Producer surplus estimates... legally retain wreckfish, by definition, producer surplus due to the harvest of wreckfish is zero. A study...
biodiversity Daniel J. Isaak, Michael K. Young, Charles H. Luce, Steven W. Hostetler, Seth J. Wenger, Erin E author on Google Scholar Find this author on PubMed Search for this author on this site Charles H. Luce climate change will cause widespread extinctions of flora and fauna in mountain environments because of
Larsen, Mette Vinther
In this article we meet Steven,the manager of a Danish regional regional medical supply organization. With him, we explore how – even for leaders – it can feel liberating to let go of existing knowledge and understanding and embark on a journey with others with the certainty that no one knows where...
Quantum physics is a central and fascinating, albeit unpopular by many students theme of physics. Steven Holzner explains understandably and alively, what must be known about quantum physics. He explains the foundations of angular momentum and spin, gives tips how complex equations can be solved. Thereby he works with examples, which he explains extensively.
almost negligible detection by EO cameras in the dark . In order to compare the estimated SfM trajectories, the point clouds created by VisualSFM for...IEEE, 2000.  Noah Snavely, Steven M Seitz, and Richard Szeliski. Photo tourism : exploring photo collections in 3d. In ACM transactions on graphics
Book Title: Letters of Stone. From Nazi Germany to South Africa. Book Author: Steven Robins. Cape Town: Penguin, 2016. 314 pp. ISBN 978 1 77609 024 2. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.17159/tvl.v.54i1.18.
... Project (MRP), comprised of a new 6,300 horsepower compressor station in Portage County, Wisconsin, all as... TTY, (202) 502-8659. Located in Portage County, Wisconsin, north of Stevens Point, Wisconsin, the MRP... service commitments of ANR's shippers in Wisconsin. ANR states that the MRP will increase the reliability...
Items 1 - 50 of 108 ... Paul Tiyambe Zeleza. Vol 2004, No 1 (2004), Africanity: \\'The (Third) World as a Ghetto\\'?: Looking for A Third Space Between \\'Postmodern\\' Cosmopolitanism and Cultural Nationalism, Abstract. Steven Robins. Vol 1999, No 3-4 (1999), Alien-Nation: Zombies, Immigrants and Millennial Capitalism, Details.
More than two years in the making, the agreement concluded by China, the EU, France, Germany, Russia, the UK and the US with Iran to prevent the ‘weaponisation’ of the latter’s nuclear programme is a big deal. But, cautions Steven Blockmans in this CEPS Commentary, it is not the silver bullet to the
Purpose: To build a microRNA and gene signature of severe cutaneous adverse drug reactions (SCAR), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Methods: MicroRNA expression profiles were downloaded from miRNA expression profile of patients' skin suffering from TEN using an ...
Mathematical Psychology and presently a graduate psychology and cognitive science student at Stanford University) developed a toolbox for standard GRT... Cognition Vol. II, A Festschrift for James T. Townsend, Scientific Psychology Series, New York: Routledge. 4. Townsend, J. T., Wenger, M. J. & Houpt...The Stevens Handbook of Experimental Psychology and Cognitive Neurosicence. Chichester, West Sussex; Malden, MA: John Willey and Sons Inc. 5
10 déc. 2015 ... 5. Chandler JR, Langenbrunner DJ, Stevens ER. The Pathogenesis. Of Orbital complications in acute sinusitis. Laryngoscope. 1970. Sep; 80(9): 1414-28. PubMed | Google Scholar. 6. Hodges E, Tabbara KF. Orbital cellulitis: review of 23 cases from Saudi Arabia. Br J Ophthalmol. 1989 Mar; 73(3): 205-8.
Scheerder, J.; Breedveld, K.
Who is doing a run with the running boom? The growth and governance of one of Europe's most popular sport activities / Jeroen Scheerder, Koen Breedveld and Julie Borgers -- Belgium (Flanders): trends and governance in running / Julie Borgers, Steven Vos and Jeroen Scheerder -- Denmark: running for
Filmiprodutsent Sheldon Abendi pärijad nõuavad Steven Spielbergilt, tootjatelt DreamWorks ja Paramount Pictures kahjutasu filmi "Disturbia" linastamise eest, kuna see kopeerivat Cornell Woodrichi lühijuttu, mille järgi tegi A. Hitchcock filmi "Rear Window" ning mille autoriõigused kuuluvad S. Abendi pärijatele
Andrew E. Bowkett, Trevor Jones, Francesco Rovero, Martin R. Nielsen, Amy B. Plowman, Jamie R. Stevens, 91-125 ... Andrew R. Marshall, Ricardo J.R. Lemos de Figueiredo, Roy E. Gereau, Yahya Abeid, Antje Ahrends, Eibleis Fanning, Trevor Jones, Jon C. Lovett, Cara J. Marshall, Tim R.B. Davenport, Claire E.
Dissing, Kristina Boe; Hartvigsen, Jan; Wedderkopp, Niels
Title Spinal pain in Danish school children – how often and how long? The CHAMPS Study-DK Authors First author: Kristina Boe Dissing1 Last author: Lise Hestbæk1,2 Co-authors: Jan Hartvigsen1,2, Christopher Williams3,4, Steven Kamper5, Eleanor Boyle1, Niels Wedderkopp6,7 Affiliations 1 Department...
... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Conduct and operation of a fishery negotiation panel. 600.756 Section 600.756 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Fishery Negotiation Panels § 600.756 Conduct and...
... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Establishment of a fishery negotiation panel. 600.755 Section 600.755 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Fishery Negotiation Panels § 600.755 Establishment of a...
... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Decision to establish a fishery negotiation panel. 600.754 Section 600.754 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Fishery Negotiation Panels § 600.754 Decision to...
... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Notice of intent to establish a fishery negotiation panel. 600.753 Section 600.753 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Fishery Negotiation Panels § 600.753 Notice...
... Hillary Rodham Clinton has determined that the recent deaths of Ambassador J. Christopher Stevens..., Libya involved loss of life at or related to a U.S. mission abroad. Therefore, Secretary Clinton has... cooperation. The Board will submit its conclusions and recommendations to Secretary Clinton within 60 days of...
Craig Symes, Mark Brown, Louise Warburton, Michael Perrin, Colleen Downs, 106-109 ... The Birds of Hispaniola (an annotated checklist) by Allan R Keith, James W Wiley, Steven C Latta and JosE9 A Ottenwalder ... WRJ Dean, 184-185.
Shamburger, Content Editor Sherry Terrell , Editorial Assistant Steven C. Garst, Director of Art and Pdaction Daniel M. Armstrong, Illustrator Nedra Looney...Ibid. 41 . Ann Scott I son, "US Army Battling to Save Equipment," Washington Post, 5 December 2006. 42. John A. Tirpak, "Warning: USAF is ’Going out
Opinions and Thoughts Air University Press Team Chief Editor Jeanne Shamburger Copy Editor Sherry Terrell Cover Art and Book...Design Steven C. Garst Illustrations Daniel Armstrong Composition and Prepress Production Ann Bailey Quality Review Mary J. Moore Print Preparation Joan Hickey Distribution Diane Clark
Wieling, Wouter; Jardine, David L.; de Lange, Frederik J
. Plethysmographic measurements were intermittent and not frequent enough to capture rapid changes in blood flow during progressive hypotension. However, later investigations by Weissler, Murray, and Stevens performed between 1950 and 1970 used invasive beat-to-beat BP measurements and more frequent measurements...
.... Response: This comment seems to be based on a misunderstanding of the management measures in Amendment 5... Monkfish Fishery Management Plan (FMP). The New England and Mid-Atlantic Fishery Management Councils... accountability measure (AM) requirements of the Magnuson-Stevens Fishery Conservation and Management Act...
... Magnuson-Stevens Act requires fishery managers to end overfishing of stocks and to minimize bycatch and..., which would lower overall cost, or as a marketing tool to attract additional angler trips, which could... illegal, this practice could pose problems in tracking recreational versus commercial landings of snapper...
Maron, Michael B.
In 1973, the Institute of Environmental Stress of the University of California-Santa Barbara, under the direction of Steven M. Horvath, began a series of field and laboratory studies of marathon runners during competition. As one of Horvath's graduate students, many of these studies became part of my doctoral dissertation. The rationale for…
.... Crocetti Jr., Louis D. Cullen, Susan M. Cummiskey, Chris Daitch, William Davis, Delia P. Dayton, Mark de.... Armstrong, Charles R. Ayala, Janice Aytes, Michael L. Bacon, Roxana Baldwin, William D. Baroukh, Nader Barr... Brundage, William Bucella, Donna A. Bucher, Steven P. Buckingham, Patricia A. Burke, Richard Butcher...
for public release ; distribution is unlimited. 4 Figure 3. First Kuroshio survey. Colors show MODIS SST image. Inset shows the survey...Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA. *To whom correspondence should be addressed. E-mail: firstname.lastname@example.org 15
Biederman, Joseph; Spencer, Thomas J.; Wilens, Timothy E.; Prince, Jefferson B.; Faraone, Stephen V.
This article is a response to Dr. Steven E. Nissen's comments (Nissen, 2006) about attention deficit/hyperactivity disorder (ADHD) and its treatment with stimulant medications. In this article, the authors refute his arguments and provide accurate information. Here, they answer the questions, such as: (1) Do stimulants increase the risk for sudden…
Valme, Valner, 1970-
Uutest heliplaatidest Talib Kweli "The Beautiful Struggle", Evanescence "Anywhere But Home", Fly Pan Am "N'Ecoutez Pas", Status Quo "XS All Areas - The Greatest Hits", Stevens, Shakin "Collectable", Europe "Rock The Night. Very Best Of", Nas "Video Anthology", Nas "Street Disciple", Miossec "1964"
Kogupere ulmefilm "E.T. - sõber kaugelt" ("E.T. The Extra-Terrestrial") : režissöör Steven Spielberg : Ameerika Ühendriigid 1982. Restaureeritud ja paari omal ajal välja jäetud stseeniga täiendatud uusversioon
Kogupere ulmefilm "E.T. - sõber kaugelt" ("E.T. The Extra-Terrestrial") : režissöör Steven Spielberg : Ameerika Ühendriigid 1982. Restaureeritud ja paari omal ajal välja jäetud stseeniga täiendatud uusversioon
... States this year. Women will be disproportionately affected constituting 76% of these new cases... to develop more accurate diagnostic tests to detect thyroid cancer. Inventors: Steven K. Libutti (NCI... necessarily limited to, cancer, inflammation, and tumor progression or regression. Inventors: Thomas H. Bugge...
described by the Watts and Strogatz model (Watts & Strogatz , 1998). Based on the Watts and Strogatz model, the AF can be viewed as a small world...chemical casualties handbook (Vol. 7). Fort Detrick, MD: U.S. Government Printing Office. Watts, Duncan, & Strogatz , Steven (1998). Collective dynamics of
... Crossing Agreement and replace the current crossing diamond with a turnout and switches lining CSXT's spur into NSR's spur north of Craven's Yard. CSXT states that, by retiring the crossing diamond, the parties... served on Steven C. Armbrust, Esq., CSX Transportation, Inc., 500 Water Street J-150, Jacksonville, FL...
...-Stevens Act), the NMFS Assistant Administrator has determined that this final rule is consistent with the...: March 28, 2011. Samuel D. Rauch III, Deputy Assistant Administrator for Regulatory Programs, National...; current estimates of fishing mortality; stock status; recent estimates of recruitment; virtual population...
.... Classification Pursuant to section 304(c)(1)(A) of the Magnuson-Stevens Act, the NMFS Assistant Administrator has..., Deputy Assistant Administrator for Regulatory Programs, National Marine Fisheries Service. For the...-effort (CPUE); discards; stock status; recent estimates of recruitment; virtual population analysis...
... prevent overfishing on a continuing basis, as required by National Standard 1 of the Magnuson-Stevens Act... expected to achieve OY and prevent overfishing on a continuing basis, the PDT shall recommend to the... overfishing on a continuing basis. When making the status determination in the SAFE Report, the PDT shall...
... accountability measures (AMs) to prevent overfishing in the target fishery for weathervane scallops. Implementing... statewide estimate of spawning biomass for weathervane scallops, the overfishing level (OFL) is specified as...-Stevens Act relative to preventing overfishing and establishing an ABC and ACL. The following is a summary...
... measures (AMs) for nine snapper-grouper species, eight of which are undergoing overfishing; specify... address overfishing of eight snapper-grouper species while maintaining catch levels consistent with...-Stevens Act in 2006 require that if a stock or stock complex in an FMP is undergoing overfishing, the FMP...
Canning, Steven; Betrus, Anthony
This article is written in the first-person, from the perspective of Steven Canning, a SUNY Potsdam instructor of educational technology and part-time professional gamer, with contributions from Anthony Betrus, Professor of Educational Technology at SUNY Potsdam. The author delves deeply into the world of professional online gaming, or eSports,…
Stenner , R.D., Merdink, J.L., Fisher, J.W., and Bull, R., Physiologically-based pharmacokinetic model for trichloroethylene considering enterohepatic...B6C3F1 mice. Toxicol. Appl. Pharmacol., 123, 1- 8, 1993. 21. Templin, M.V., Stevens, D.K., Stenner , R.D., Bonate, P.L., Tuman, D., and Bull, R.J
and free trichloroethanol. Toxicol. App!. Pharmacol., 152, 339-359, 1998. 10. Stenner , R.D., Merdink, J.L., Fisher, J.W., and Bull, R...M.V., Stevens, D.K., Stenner , R.D., Bonate, P.L., Tuman, D., and Bull, R.J., Factors affecting species differences in the kinetics of metabolites of
Ruus, Kertu, 1977-
Autor võrdleb Apple'i asutajat ja juhti Steve Jobsi Eesti meediaärimehe Hans H. Luigega. Vt. samas: Jobs: ärge raisake aega teiste elu elamisele; Forbes: iPhone'ist saab Apple'i suur hitt; CV: Steven Paul Jobs. Diagramm: Apple'i aktsia
bureaucratically appealing, politically correct, and relatively useless. Gabriel Marcella & Steven Fought “Teaching Strategy in the 21st Century” JFQ...achieve objectives, within the limits imposed by policy Gabriel Marcella & Stephen Fought “Teaching Strategy in the 21st Century” JFQ (2009) 70
study report. Qual Life Res 2007;16(6):947–960. 162. Vgontzas AN, Zoumakis E, Bixler EO, Lin HM, Follett H, Kales A, et al. Adverse effects of modest...9 10. Li Y, CB Ambrosone, MJ McCullough, J Ahn, VL Stevens, MJ Thun3, C Hong+. Oxidative Stress Related Genotypes, Fruit and Vegetable Consumption
conditions (e.g., dry eyes , mild cataractous conditions, Stevens-Johnson Syndrome ) using CS alone as the performance index. More commonly, it has been...subjects tested under conditions of spherical blur, astigmatic blur, low luminance, and one eye vs. two eyes ...conditions). The vast majority of past mesopic visual performance studies were predominantly isolated to evaluations of various eye disease
...). This emergency action increases the butterfish allowable biological catch (ABC) for the 2011 fishing... CONTACT: Aja Peters-Mason, Fishery Policy Analyst, (978) 281-9195, fax (978) 281-9135. SUPPLEMENTARY... Magnuson-Stevens Act, to increase the butterfish ABC for the 2011 fishing year (FY) from 1,500 mt to 1,811...
Full Text Available OWL, Description Graphs and Rules Janna Hastings1;2;3?, Michel Dumontier4, Duncan Hull1, Matthew Horridge5, Christoph Steinbeck1, Ulrike Sattler5, Robert Stevens5, Tertia H orne2, and Katarina Britz2;3 1 European Bioinformatics Institute, UK 2...
Full Text Available , Description Graphs and Rules Janna Hastings1;2;3?, Michel Dumontier4, Duncan Hull1, Matthew Horridge5, Christoph Steinbeck1, Ulrike Sattler5, Robert Stevens5, Tertia H orne2, and Katarina Britz2;3 1 European Bioinformatics Institute, UK 2 University...