Polymeri utoopiline festival meelitab uue maailma kunstnikke / Sandra Jõgeva ; intervjueerinud Mari Peegel

Index Scriptorium Estoniae

Jõgeva, Sandra, 1976-

2011-01-01

Festivali kava üks koostajaid Sandra Jõgeva 24.-28. augustini 2011 toimuvast kultuuritehase Polymer festivalist ja tähtsamatest esinejatest. Selle aasta festivalil tegeldakse utoopiliste visioonidega

The second-phase development of the China JinPing underground Laboratory

OpenAIRE

Li, Jainmin; Ji, Xiangdong; Haxton, Wick; Wang, Joseph S. Y.

2014-01-01

During 2013-2015 an expansion of the China JinPing underground Laboratory (CJPL) will be undertaken along a main branch of a bypass tunnel in the JinPing tunnel complex. This second phase of CJPL will increase laboratory space to approximately 96,000 m^3, which can be compared to the existing CJPL-I volume of 4,000 m^3. One design configuration has eight additional hall spaces, each over 60 m long and approximately 12 m in width, with overburdens of about 2.4 km of rock, oriented parallel to ...

Use of Awamori-pressed Lees and Tofu Lees as Feed Ingredients for Growing Female Goats

Directory of Open Access Journals (Sweden)

Itsuki Nagamine

2012-12-01

Full Text Available Okinawan Awamori is produced by fermenting steamed indica rice with black mold, yeast, and water. Awamori-pressed lees is a by-product of the Awamori production process. Tofu lees is a by-product of the Tofu production process. This research consisted of two experiments conducted to elucidate whether or not dried Awamori-pressed lees and Tofu lees can be used as a mixed feed ingredient for raising female goats. In experiment 1, digestion trials were conducted to ascertain the nutritive values of dried Awamori-pressed lees and dried Tofu lees for goats. The digestible crude protein (DCP and total digestible nutrients (TDN contents of dried Awamori-pressed lees and Tofu lees were 22.5%, 22.5% (DCP, and 87.2%, 94.4% (TDN respectively. In experiment 2, 18 female goats (Japanese Saanen×Nubian, three months old, body weight 15.4±0.53 kg were divided into three groups of six animals (control feed group (CFG, Awamori-pressed lees mixed feed group (AMFG, Tofu lees mixed feed group (TMFG. The CFG control used feed containing 20% soybean meal as the main protein source, while the AMFG and TMFG treatments used feed mixed with 20% dried Awamori-pressed lees or dried Tofu lees. The groups were fed mixed feed (volume to provide 100 g/d increase in body weight twice a day (10:00, 16:00. The klein grass hay and water was given ad libitum. The hay intake was measured at 08:00 and 16:00. Body weight and size measurements were taken once a month. At the end of the experiment, a blood sample was drawn from the jugular vein of each animal. The DCP and TDN intakes in AMFG and TMFG showed no significant difference to the CFG. Cumulative measurements of growth in body weight, withers height, chest depth, chest girth, and hip width over the 10 mo period in the AMFG and TMFG were similar to the CFG. By contrast, cumulative growth in body length and hip height in the AMFG and TMFG tended to be larger than the CFG. Cumulative growth in chest width in the AMFG was

Inhibition of Inducible Nitric Oxide Synthase, Cycleooxygenase-2 ...

African Journals Online (AJOL)

HP

Won Chung, Jin Uk Oh, Sehyung Lee and Sung-Jin Kim* ... was determined by Western blot analysis for iNOS and COX-2 expression in LPS-stimulated RAW ..... Nitric oxide-scavenging and antioxidant effects ofUraria crinite root. Food.

[Learning experience of acupuncture technique from professor ZHANG Jin].

Science.gov (United States)

Xue, Hongsheng; Zhang, Jin

2017-08-12

As a famous acupuncturist in the world, professor ZHANG Jin believes the key of acupuncture technique is the use of force, and the understanding of the "concentrating the force into needle body" is essential to understand the essence of acupuncture technique. With deep study of Huangdi Neijing ( The Inner Canon of Huangdi ) and Zhenjiu Dacheng ( Compendium of Acupuncture and Moxibustion ), the author further learned professor ZHANG Jin 's theory and operation specification of "concentrating force into needle body, so the force arriving before and together with needle". The whole-body force should be subtly focused on the tip of needle, and gentle force at tip of needle could get significant reinforcing and reducing effect. In addition, proper timing at tip of needle could start reinforcing and reducing effect, lead qi to disease location, and achieve superior clinical efficacy.

Battling Machismo in the Poetry and Prose of Sandra Cisneros.

Science.gov (United States)

Breshears, Russell D.

Sandra Cisneros is giving a voice to farm workers, migrant workers, and Latinos living in the inner cities across the United States in poems and short stories that call attention to gender, class, and race issues that many would prefer to ignore. While her women protagonists challenge destructive "machismo," which takes the form of…

Nüüd kunst, nüüd tulevik / Sandra Jõgeva

Index Scriptorium Estoniae

Jõgeva, Sandra, 1976-

2008-01-01

Vilniuse II rahvusvaheline graafikabiennal "Present Time. Now Art Now Future" Vilniuse Kaasaegse Kunsti Keskuses kuni 11. V. Kuraatorid Ignas Kazakevicius ja Jurate Rekeviciute. Eestist osalevad Peeter Allik, Eve Kask ja Sandra Jõgeva. Kuraator Jurate Rekeviciute biennaali alanäitusest "Valmis ajalooks" Gediminase avenüü kaubanduskeskuse galeriis

Use of Awamori-pressed Lees and Tofu Lees as Feed Ingredients for Growing Male Goats

Directory of Open Access Journals (Sweden)

Itsuki Nagamine

2013-09-01

Full Text Available Awamori is produced by fermenting steamed indica rice. Awamori-pressed lees is a by-product of the Awamori production process. Tofu lees is a by-product of the Tofu production process. Research was conducted to test if dried Awamori-pressed lees and Tofu lees can be used as a mixed feed ingredient for raising male goats. Eighteen male kids were divided into three groups of six animals (control feed group (CFG, Awamori-pressed lees mixed feed group (AMFG, Tofu lees mixed feed group (TMFG. The CFG used feed containing 20% soybean meal as the main protein source, while the AMFG and TMFG used feed mixed with 20% dried Awamori-pressed lees or dried Tofu lees. The groups were fed mixed feed (volume to provide 100 g/d increase in body weight and alfalfa hay cubes (2.0 kg/d twice a day (10:00, 16:00. Klein grass hay and water was given ad libitum. Hay intake was measured at 10:00 and 16:00. Body weight and size measurements were taken once a month. At the end of the experiment, a blood sample was drawn from the jugular vein of each animal and the carcass characteristics, the physical and chemical characteristics of loin were analyzed. DCP and TDN intakes in AMFG and TMFG showed no significant difference to the CFG. Cumulative measurements of growth in body weight and size over the 10 mo period in the AMFG and TMFG were similar to the CFG. Blood parameter values were similar to those in normal goats. Dressing carcass weight and percentages, and total weight of meat in the AMFG were similar to that in the CFG, but smaller in the TMFG. The compressed meat juice ratio was higher in both the TMFG and AMFG than the CFG. While the fat in corn, Awamori-pressed lees, and Tofu lees contains more than 50% linoleic acid, the loin fat in both the AMFG and TMFG was very low in linoleic acid due to the increase in the content of oleic acid, stearic acid, and palmitic acid. This indicates that feeding on AMF and TMF does not inhibit hydrogenation by ruminal

Měkkýši Národní přírodní rezervace Soos Molluscs (Mollusca of the Soos National Nature Reserve

Directory of Open Access Journals (Sweden)

Jitka Horáčková

2012-12-01

Full Text Available The Soos National Nature Reserve nearby Františkovy Lázně Town (Western Bohemia, Czech Republic is a spectacular peatbog site with the occurrence of fens on numerous mineral spring effluents, emanations of pure carbon dioxide in mofettes (i.e. false mud volcanoes, parts with saltwater wetlands, and diatomite mantel in its central part. These natural conditions affect general character of all habitats, vegetation and malacocoenoses in the reserve. Altogether, 31 mollusc species were found there, but only two of them are considered as near threatened (Pisidium obtusale and Vertigo substriata. The majority of recorded assemblage was composed of common and generalist mollusc species.

[Influences of Confucianism, Taoism and Buddhism on Chinese Medical Formulas in Jin-Tang Dynasties].

Science.gov (United States)

Wu, Xiao-xiang

2006-04-01

In the Jin-Tang Dynasties, when Confucianism, Taoism and Buddhism contended, conflicted and well blent, forming a state of mingled thoughts of the three sects. It exerted profound influences on Chinese Medical Formulas and promoted the academic fashion of compiling books about medical formulas characterized by collecting various formulas especially the simple and proved recipes. This plays a role in the formation of the formulas used in the Jin-Tang Dynasties, featuring simplicity, convenience, cheapness, and effectiveness, different from those of other periods.

Water footprint of Jing-Jin-Ji urban agglomeration in China

Science.gov (United States)

Zhao, D.

2017-12-01

A rapidly expanding economy and increasing water demand for economic production is placing enormous stress on water quantity and aquatic environment in Northern China, especially the so-called Jing-Jin-Ji (Beijing-Tianjin-Hebei) urban agglomeration. Several studies have focused on energy consumption, air pollution, CO2 emissions and regional blue water footprint (WF) following release of the Jing-Jin-Ji Integration Strategy by the China government. However, a comprehensive assessment distinguishing blue, green and grey WF amongst different industrial sectors, ascertaining how WF transfers internally and beyond the region and final demand consumption is not available. In this study, we quantified the WF and virtual water flow on a sectoral basis for the year 2010 through coupling the multi-regional input-output model (MRIO) with WF assessment. The results showed that Beijing and Tianjin are net importers of green, blue and grey water from Hebei and other provinces to support their needs. Conversely, Hebei exports all WF colors to Beijing, Tianjin and other provinces in China, more than 60% of WF is transferred as virtual water. For the overall Jing-Jin-Ji region a small amount of blue water (2,086 million m3) is exported, but huge amounts of green water (15,573 million m3) and grey water (30,620 million m3) are outsourced. A "Virtual Water Strategy" is one measure which could alleviate water stress at the regional scale, with consideration of financial compensation from water receiving regions made to water supplying regions for achieving water management targets. We also found that physical water transfer to Jing-Jin-Ji could not balance virtual blue water exports. Our research suggests that a continuation of an export-based economic development model will worsen Hebei's water stress. Reducing the dependency of Hebei's sectoral economy on export of water intensive and low value added agricultural products may be one strategy to reduce the pressure on regional water

Mi Casa Es Su Casa: Sandra Tauler--City Librarian, Calexico, CA

Science.gov (United States)

Library Journal, 2005

2005-01-01

Sandra Tauler has tailored her collection and services to the needs of a community that is 97 percent Hispanic. Unfortunately, that's only half the job. The other half is getting potential users through the door. The solution Tauler and other Imperial Valley librarians came up with was Proyecto Televista. With LSTA funding, and the assistance of…

Comment on "Combination of cupric ion with hydroxylamine and hydrogen peroxide for the control of bacterial biofilms on RO membranes by Hye-Jin Lee, Hyung-Eun Kim, Changha Lee [Water Research 110, 2017, 83-90]".

Science.gov (United States)

Chen, Long; Peng, Ying; Tang, Min; Wu, Feng

2017-07-01

The methodology employed by Lee et al. to terminate their bactericidal assays was found to be flawed via our demonstrations. Briefly, EDTA or sulfite combining with cupric ion did not fully terminate, and instead even boosted the P. aeruginosa death. We therefore suggested them to seek for other means of reaction termination, such as the combination of buffering agent PBS and Cu(II)-complexing agent EDTA. Copyright © 2017 Elsevier Ltd. All rights reserved.

Treatment of wine lees on an industrial scale. [wine lees processing

Energy Technology Data Exchange (ETDEWEB)

1978-04-24

EtOH and tartaric acid are recovered from wine lees by compressing the lees into pellets, distillation with steam to remove alcohols followed by fractional distillation to recover EtOH, roasting and pulverization of the EtOH-free pellets to coagulate collids, and extraction of the suspension with water and mineral acid to recover tartaric acid. Mother liquors are recirculated through the tartaric acid recovery process and the residual material is dried to a protein product which is useful as fertilizer or as animal feed.

Optimization and physicochemical characterization of a cationic lipid-phosphatidylcholine mixed emulsion formulated as a highly efficient vehicle that facilitates adenoviral gene transfer

Directory of Open Access Journals (Sweden)

Kim SY

2017-10-01

Full Text Available Soo-Yeon Kim,1,2 Sang-Jin Lee,2 Jin-Ki Kim,3 Han-Gon Choi,3 Soo-Jeong Lim1 1Department of Bioscience and Bioengineering, Sejong University, Seoul, Kwangjin-gu, Seoul, 2Immunotherapeutics Branch, Research Institute, National Cancer Center, Ilsandong-gu, Goyang-si, Gyeonggi-do, 3College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, Sangnok-gu, Ansan, Republic of Korea Abstract: Cationic lipid-based nanoparticles enhance viral gene transfer by forming electrostatic complexes with adenoviral vectors. We recently demonstrated the superior complexation capabilities of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP emulsion compared with a liposomal counterpart but the cytotoxicity of DOTAP emulsions remained a challenge. The present study is aimed at formulating an emulsion capable of acting as a highly effective viral gene transfer vehicle with reduced cytotoxicity and to physicochemically characterize the structures of virus-emulsion complexes in comparison with virus–liposome complexes when the only difference between emulsions and liposomes was the presence or absence of inner oil core. The emulsion formulation was performed by 1 reducing the content of DOTAP while increasing the content of zwitterionic lipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC, and 2 optimizing the oil content. The complexation capability of formulated DOTAP:DMPC mixed emulsions was similar to those of emulsions containing DOTAP alone while displaying significantly lower cytotoxicity. The complexation capabilities of the DOTAP:DMPC mixed emulsion were serum-compatible and were monitored in a variety of cell types, whereas its liposomal counterpart was totally ineffective. Characterization by scanning electron microscopy, transmission electron microscopy, atomic force microscopy, and dynamic light scattering studies indicated that the optimized emulsions spontaneously surrounded the virus particles to generate emulsions that

Characterization of Phenolic Compounds in Wine Lees.

Science.gov (United States)

Zhijing, Ye; Shavandi, Amin; Harrison, Roland; Bekhit, Alaa El-Din A

2018-03-25

The effect of vinification techniques on phenolic compounds and antioxidant activity of wine lees are poorly understood. The present study investigated the antioxidant activity of white and red wine lees generated at early fermentation and during aging. In this study, the total phenol content (TPC), total tannin content (TTC), mean degree of polymerization (mDP), and antioxidant activities of five white and eight red wine lees samples from different vinification backgrounds were determined. The results showed that vinification techniques had a significant ( p tannin content of the samples. White wine lees had high mDP content compared with red ones. Catechin (50-62%) and epicatechin contents were the predominant terminal units of polymeric proanthocyanidin extracted from examined samples. Epigallocatechin was the predominant extension unit of white wine lees, whereas epicatechin was the predominant compound in red wine marc. The ORAC (oxygen radical absorbance capacity) assay was strongly correlated with the DPPH (α, α-diphenyl-β-picrylhydrazyl) assay, and the results showed the strong antioxidant activities associated with red wine lees (PN > 35 mg Trolox/g FDM) (PN: Pinot noir lees; FDM: Freeze-dried Material). This study indicates that tannin is one of the major phenolic compounds available in wine lees that can be useful in human and animal health applications.

Characterization of Phenolic Compounds in Wine Lees

Science.gov (United States)

Zhijing, Ye; Shavandi, Amin; Harrison, Roland; Bekhit, Alaa El-Din A.

2018-01-01

The effect of vinification techniques on phenolic compounds and antioxidant activity of wine lees are poorly understood. The present study investigated the antioxidant activity of white and red wine lees generated at early fermentation and during aging. In this study, the total phenol content (TPC), total tannin content (TTC), mean degree of polymerization (mDP), and antioxidant activities of five white and eight red wine lees samples from different vinification backgrounds were determined. The results showed that vinification techniques had a significant (p wine lees had high mDP content compared with red ones. Catechin (50–62%) and epicatechin contents were the predominant terminal units of polymeric proanthocyanidin extracted from examined samples. Epigallocatechin was the predominant extension unit of white wine lees, whereas epicatechin was the predominant compound in red wine marc. The ORAC (oxygen radical absorbance capacity) assay was strongly correlated with the DPPH (α,α-diphenyl-β-picrylhydrazyl) assay, and the results showed the strong antioxidant activities associated with red wine lees (PN > 35 mg Trolox/g FDM) (PN: Pinot noir lees; FDM: Freeze-dried Material). This study indicates that tannin is one of the major phenolic compounds available in wine lees that can be useful in human and animal health applications. PMID:29587406

Characterization of Phenolic Compounds in Wine Lees

Directory of Open Access Journals (Sweden)

Ye Zhijing

2018-03-01

Full Text Available The effect of vinification techniques on phenolic compounds and antioxidant activity of wine lees are poorly understood. The present study investigated the antioxidant activity of white and red wine lees generated at early fermentation and during aging. In this study, the total phenol content (TPC, total tannin content (TTC, mean degree of polymerization (mDP, and antioxidant activities of five white and eight red wine lees samples from different vinification backgrounds were determined. The results showed that vinification techniques had a significant (p < 0.05 impact on total phenol and tannin content of the samples. White wine lees had high mDP content compared with red ones. Catechin (50–62% and epicatechin contents were the predominant terminal units of polymeric proanthocyanidin extracted from examined samples. Epigallocatechin was the predominant extension unit of white wine lees, whereas epicatechin was the predominant compound in red wine marc. The ORAC (oxygen radical absorbance capacity assay was strongly correlated with the DPPH (α, α-diphenyl-β-picrylhydrazyl assay, and the results showed the strong antioxidant activities associated with red wine lees (PN > 35 mg Trolox/g FDM (PN: Pinot noir lees; FDM: Freeze-dried Material. This study indicates that tannin is one of the major phenolic compounds available in wine lees that can be useful in human and animal health applications.

Traditsioonist ja uuendusest korea modernkunstis / Katrin Kivimaa

Index Scriptorium Estoniae

Kivimaa, Katrin, 1969-

2005-01-01

Souli galeriides ja muuseumides valitseb eeldatud kõrgtehnoloogilise kunsti asemel maalikunst. Pikemalt naiskunstnik Wook-kyung Choi (1940-1985) ja Jong-gu Lee näitustest ning soo- ja naisuuringute kongressist "Women's World 2005"

On the linear programming bound for linear Lee codes.

Science.gov (United States)

Astola, Helena; Tabus, Ioan

2016-01-01

Based on an invariance-type property of the Lee-compositions of a linear Lee code, additional equality constraints can be introduced to the linear programming problem of linear Lee codes. In this paper, we formulate this property in terms of an action of the multiplicative group of the field [Formula: see text] on the set of Lee-compositions. We show some useful properties of certain sums of Lee-numbers, which are the eigenvalues of the Lee association scheme, appearing in the linear programming problem of linear Lee codes. Using the additional equality constraints, we formulate the linear programming problem of linear Lee codes in a very compact form, leading to a fast execution, which allows to efficiently compute the bounds for large parameter values of the linear codes.

Farmers of Jin county want fewer children.

Science.gov (United States)

Xiao, M

1986-04-01

The economic reform practiced in the vast rural areas in China gives a great impetus to the vigorous development of rural economy and the the rapid improvement of living standard. Meanwhile, reform pounds at the traditional childbearing ideas. The striking change in the childbearing attitudes of the farmers of the Jin County is a good example. As the farmers of the country are getting well-off when the commodity economy develops rapidly with the rural economic reforms, their childbearing attitudes change. Profound changes have taken place in their mode of production and their life style. The young couples of the county begin to seek small families instead of traditional big ones. They are convinced that under the new situation of reforms, the farmers of an old generation are in no way competent as the head of the family to guide production and therefore want to build their own small families by freeing themselves from the binds of the traditional patriarchal system. The increase in the cost of bringing up children and the economic loss resulting from the absence from work for looking after children constitute another reason to prefer a small family. The son is no more the only economic guarantee for the aged. As a result of the rapid development of the rural economy, a retirement system has been established among the farmers of the Jin county. "It is unreliable to expect that the son will support his aged parents. Now it is better to earn more money and the collective can be depended upon by the aged."

Tim Berners-Lee during the WSIS

CERN Multimedia

Maximilien Brice

2003-01-01

Tim Berners-Lee stands in front of the first web server at the Geneva Palexpo during the World Summit on the Information Society (WSIS) in 2003. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

Sandra Steingraber: vähiepideemia vastu tuleb võidelda süsteemselt / intervjueerinud Epp Petrone

Index Scriptorium Estoniae

Steingraber, Sandra

2010-01-01

Vestlus ameerika bioloogi ja ise vähki põdenud Sandra Steingraberiga vähivastasest võitlusest. S. Steingraberil on ilmunud ka mitu raamatut, nendest "Having faith" on tõlgitud ka eesti keelde (Mina olen ookean. Tartu : Petrone Print, 2009)

Colon-targeted delivery of piceatannol enhances anti-colitic effects of the natural product: potential molecular mechanisms for therapeutic enhancement

Directory of Open Access Journals (Sweden)

Yum S

2015-08-01

Full Text Available Soohwan Yum, Seongkeun Jeong, Sunyoung Lee, Joon Nam, Wooseong Kim, Jin-Wook Yoo, Min-Soo Kim, Bok Luel Lee, Yunjin Jung College of Pharmacy, Pusan National University, Busan, Republic of Korea Abstract: Piceatannol (PCT, an anti-colitic natural product, undergoes extensive Phase II hepatic metabolism, resulting in very low bioavailability. We investigated whether colon-targeted delivery of PCT could enhance anti-colitic effects and how therapeutic enhancement occurred at the molecular level. Molecular effects of PCT were examined in human colon carcinoma cells and inflamed colons. The anti-colitic effects of PCT in a colon-targeted capsule (colon-targeted PCT were compared with PCT in a gelatin capsule (conventional PCT in a trinitrobenzene sulfonic acid-induced rat colitis model. Colon-targeted PCT elicited greatly enhanced recovery of the colonic inflammation. In HCT116 cells, PCT inhibited nuclear factor kappaB while activating anti-colitic transcription factors, nuclear factor-erythroid 2 (NF-E2 p45-related factor 2, and hypoxia-inducible factor-1. Colon-targeted PCT, but not conventional PCT, modulated production of the target gene products of the transcription factors in the inflamed colonic tissues. Rectal administration of PCT, which simulates the therapeutic action of colon-targeted PCT, also ameliorated rat colitis and reproduced the molecular effects in the inflamed colonic tissues. Colon-targeted delivery increased therapeutic efficacy of PCT against colitis, likely resulting from multitargeted effects exerted by colon-targeted PCT. The drug delivery technique may be useful for therapeutic optimization of anti-colitic lead compounds including natural products. Keywords: piceatannol, colitis, colon-targeted delivery, multitarget, polypharmacology

76 FR 30947 - Stephen Lee Seldon: Debarment Order

Science.gov (United States)

2011-05-27

...] Stephen Lee Seldon: Debarment Order AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY... Act (the FD&C Act) permanently debarring Stephen Lee Seldon, M.D. from providing services in any... authority delegated to the Director (Staff Manual Guide 1410.35), finds that Stephen Lee Seldon has been...

Interactions between yeast lees and wine polyphenols during simulation of wine aging. II. Analysis of desorbed polyphenol compounds from yeast lees.

Science.gov (United States)

Mazauric, Jean-Paul; Salmon, Jean-Michel

2006-05-31

In the first part of this work, the analysis of the polyphenolic compounds remaining in the wine after different contact times with yeast lees during simulation of red wine aging was undertaken. To achieve a more precise view of the wine polyphenols adsorbed on lees during red wine aging and to establish a clear balance between adsorbed and remnant polyphenol compounds, the specific analysis of the chemical composition of the adsorbed polyphenolic compounds (condensed tannins and anthocyanins) after their partial desorbtion from yeast lees by denaturation treatments was realized in the second part of the study. The total recovery of polyphenol compounds from yeast lees was not complete, since a rather important part of the initial wine colored polyphenols, especially those with a dominant blue color component, remained strongly adsorbed on yeast lees, as monitored by color tristimulus and reflectance spectra measurements. All anthocyanins were recovered at a rather high percentage (about 62%), and it was demonstrated that they were not adsorbed in relation with their sole polarity. Very few monomeric phenolic compounds were extracted from yeast lees. With the use of drastic denaturing treatments, the total recovery of condensed tannins reached 83%. Such tannins extracted from yeast lees exhibited very high polymeric size and a rather high percentage of galloylated residues by comparison with initial wine tannins, indicating that nonpolar tannins were preferentially desorbed from yeast lees by the extraction treatments.

Higher-derivative Lee-Wick unification

International Nuclear Information System (INIS)

Carone, Christopher D.

2009-01-01

We consider gauge coupling unification in Lee-Wick extensions of the Standard Model that include higher-derivative quadratic terms beyond the minimally required set. We determine how the beta functions are modified when some Standard Model particles have two Lee-Wick partners. We show that gauge coupling unification can be achieved in such models without requiring the introduction of additional fields in the higher-derivative theory and we comment on possible ultraviolet completions.

AMS radiocarbon dating of cemetery of Jin Marquises in China

CERN Document Server

Wu, X; Wang, J; Guo, Z; Liu, K; Lü, X; Ma, H; Li, K; Yuan, J; Cai, L

2000-01-01

Bones are very important samples to determine the hosts of the cemetery of Jin Marquises which were excavated at Tianma-Qucun site in Shanxi Province in China. In order to obtain accurate AMS radiocarbon dates, bones were pretreated by two kinds of methods, the gelatin-extraction method and the amino-acid method. Charcoals collected from the same sites were also used. The measured dates agree with historical record.

Sandra Szir (coord., Ilustrar e imprimir. Una historia de la cultura gráfica en Buenos Aires, 1830-1930

Directory of Open Access Journals (Sweden)

Antonela Pandolfi

2017-09-01

Full Text Available Reseña bibliográfica del libro de Sandra Szir (coord., Ilustrar e imprimir. Una historia de la cultura gráfica en Buenos Aires, 1830-1930, Buenos Aires, Ampersand, 2016, 298 pp. Ilustrar e imprimir. Una historia de la cultura gráfica en Buenos Aires, 1830-1930 reúne a un grupo de investigadores coordinados por Sandra Szir.  Se toman diferentes objetos de estudio relacionados con el diseño gráfico y se los analizan en función de la disciplina correspondiente pero también relacionados con el contexto histórico en el cual se enmarcan.

Constraints on the Lee-Wick Higgs sector

International Nuclear Information System (INIS)

Carone, Christopher D.; Primulando, Reinard

2009-01-01

Lee-Wick partners to the standard model Higgs doublet may appear at a mass scale that is significantly lower than that of the remaining Lee-Wick partner states. The relevant effective theory is a two-Higgs doublet model in which one doublet has wrong-sign kinetic and mass terms. We determine bounds on this effective theory, including those from neutral B-meson mixing, b→X s γ, and Z→bb. The results differ from those of conventional two-Higgs doublet models and lead to meaningful constraints on the Lee-Wick Higgs sector.

The Earl Lee Street Art Campaign

Science.gov (United States)

Bubba

2013-01-01

This article describes a catchy phrase with more to its meaning than first view. A slogan "All the girls love Earl Lee," appears in street art around the world. Earl Lee is a lovable, handsome man who owns the fictitious Earl Lube industries. Originally intended to bring a smile to people's faces at a time when there wasn't much to smile…

Tim Berners-Lee receives the Millennium Technology Prize

CERN Multimedia

2004-01-01

On 15 April, for his invention of the Web, Tim Berners-Lee was awarded the first ever Millennium Technology Prize by the Finnish Technology Award Foundation, which recognises technological innovations of lasting benefit to society. "Tim Berners-Lee's invention perfectly encapsulates the spirit of the Prize. The Web is encouraging new types of social networks, contributing to transparency and democracy, and opening up new avenues for information management and business development," underlined Pekka Tarjanne, chairman of the jury and former Secretary-General of the International Telecommunication Union (ITU). Tim Berners-Lee is congratulated by Jukka Valtasaari, Finland's Ambassador to the United States. Tim Berners-Lee created the first server, browser and editor, the HTML code, the URL address and the HTTP transmission protocol at CERN in 1990. CERN released the Web into the public domain in 1993. Tim Berners-Lee is currently head of the World Wide Web Consortium, managed by ERCIM (Europe...

Lapset median käyttäjinä

OpenAIRE

Jalonen, Taru; Suomela, Sonja

2010-01-01

Laurea-ammattikorkeakoulu Tiivistelmä Hyvinkää Sosiaali-, terveys- ja liikunta-ala Hoitotyön koulutusohjelma Terveydenhoitaja AMK Sairaanhoitaja AMK Taru Jalonen, Sonja Suomela Lapset median käyttäjinä Vuosi ‎2010‎ Sivumäärä ‎63‎ Tämän opinnäytetyön tarkoituksena oli selvittää lasten tottumuksia ja kokemuksia mediasta sekä ‎niiden herättämiä tunteita. Lisäksi selvitimme lasten käyttämiä mediaympäristöjä sekä median ‎näkymistä lasten leikeissä. Tämä työ on os...

Study on embodied CO2 transfer between the Jing-Jin-Ji region and other regions in China: a quantification using an interregional input-output model.

Science.gov (United States)

Chen, Mengmeng; Wu, Sanmang; Lei, Yalin; Li, Shantong

2018-03-08

Jing-Jin-Ji region (i.e., Beijing, Tianjin, and Hebei) is China's key development region, but it is also the leading and most serious air pollution region in China. High fossil fuel consumption is the major source of both carbon dioxide (CO 2 ) emissions and air pollutants. Therefore, it is important to reveal the source of CO 2 emissions to control the air pollution in the Jing-Jin-Ji region. In this study, an interregional input-output model was applied to quantitatively estimate the embodied CO 2 transfer between Jing-Jin-Ji region and other region in China using China's interregional input-output data in 2010. The results indicated that there was a significant difference in the production-based CO 2 emissions in China, and furthermore, the Jing-Jin-Ji region and its surrounding regions were the main regions of the production-based CO 2 emissions in China. Hebei Province exported a large amount of embodied CO 2 to meet the investment, consumption, and export demands of Beijing and Tianjin. The Jing-Jin-Ji regions exported a great deal of embodied CO 2 to the coastal provinces of southeast China and imported it from neighboring provinces.

Radiation bounce from the Lee-Wick construction?

International Nuclear Information System (INIS)

Karouby, Johanna; Brandenberger, Robert

2010-01-01

It was recently realized that matter modeled by the scalar field sector of the Lee-Wick standard model yields, in the context of a homogeneous and isotropic cosmological background, a bouncing cosmology. However, bouncing cosmologies induced by pressureless matter are in general unstable to the addition of relativistic matter (i.e. radiation). Here we study the possibility of obtaining a bouncing cosmology if we add not only radiation, but also its Lee-Wick partner, to the matter sector. We find that, in general, no bounce occurs. The only way to obtain a bounce is to choose initial conditions with very special phases of the radiation field and its Lee-Wick partner.

Web Inventor Berners-Lee starts a Blog

CERN Multimedia

Olson, Parmy

2005-01-01

Berners-Lee created what is known today as the World Wide Web. Now, just in time for the Web's 15th anniversary and after taking his proverbial stroll around the global dwelling of cyberspace, Berners-Lee is chatting with the rest of us about what he thinks with a blog

Interprovincial transfer of embodied energy between the Jing-Jin-Ji area and other provinces in China: A quantification using interprovincial input-output model.

Science.gov (United States)

Chen, Weiming; Wu, Sanmang; Lei, Yalin; Li, Shantong

2017-04-15

Commodity trade between regions implies a large amount of energy transfer. As an important economic growth pole of China, the Jing-Jin-Ji area (Beijing-Tianjin-Hebei) is also one of the areas with the largest energy consumption in China. Moreover, the primary energy consumer goods in this area are fossil fuels, such as coal. This has led to serious air pollution in the area. Therefore, the reduction of energy consumption under the premise of maintaining sustained economic growth is an important task of the Jing-Jin-Ji area. In this study, an interprovincial input-output model was applied to quantitatively estimate the embodied energy transfer between Jing-Jin-Ji area and other provinces in China. The results indicated that the Metal and nonmetal mineral processing industry and the Electrical, gas and water industry in the Jing-Jin-Ji area exported a large amount of embodied energy to the Yangtze River Delta and the Pearl River Delta. However, the embodied energy export of the Jing-Jin-Ji area mainly exported by Hebei province. Beijing and Tianjin even have some net import of embodied energy. The embodied energy transfer between Tianjin, Hebei and other provinces was mainly driven by investment, while the main media of embodied energy transfer between Beijing and other provinces was consumption. Therefore, we suggest that the Jing-Jin-Ji area should further increase the degree of dependence on other provinces' energy-intensive products and reduce the export of energy-intensive products. In addition, there should be difference in the energy and industrial policies among Beijing, Tianjin and Hebei, and the problems of high energy consumption and high proportion of heavy industry in Hebei should be first resolved. Copyright © 2017 Elsevier B.V. All rights reserved.

Complete synchronization of two Chen-Lee systems

International Nuclear Information System (INIS)

Sheu, L-J; Chen, J-H; Chen, H-K; Tam, L-M; Lao, S-K; Chen, W-C; Lin, K-T

2008-01-01

This study demonstrates that complete synchronization of two Chen-Lee chaotic systems can be easily achieved. The upper bound of the Chen-Lee chaotic system is estimated numerically. A controller is designed to synchronize two chaotic systems. Sufficient conditions for synchronization are obtained using Lyapunov's direct method. Two numerical examples are presented to verify the proposed synchronization approach

Drug–drug interaction of microdose and regular-dose omeprazole with a CYP2C19 inhibitor and inducer

OpenAIRE

Park G; Bae SH; Park W; Han S; Park M; Shin S; Shin YG; Yim DS

2017-01-01

Gab-jin Park,1 Soo Hyeon Bae,1 Wan-Su Park,1 Seunghoon Han,1 Min-Ho Park,2 Seok-Ho Shin,2 Young G Shin,2 Dong-Seok Yim1,2 1Department of Clinical Pharmacology and Therapeutics, Seoul St Mary’s Hospital, PIPET (Pharmacometrics Institute for Practical Education and Training), College of Medicine, Catholic University of Korea, Seoul, South Korea; 2College of Pharmacy, Chungnam National University, Daejeon, South Korea Purpose: A microdose drug–drug interaction (DDI) study may be a ...

Research of Ancient Architectures in Jin-Fen Area Based on GIS&BIM Technology

Science.gov (United States)

Jia, Jing; Zheng, Qiuhong; Gao, Huiying; Sun, Hai

2017-05-01

The number of well-preserved ancient buildings located in Shanxi Province, enjoying the absolute maximum proportion of ancient architectures in China, is about 18418, among which, 9053 buildings have the structural style of wood frame. The value of the application of BIM (Building Information Modeling) and GIS (Geographic Information System) is gradually probed and testified in the corresponding fields of ancient architecture’s spatial distribution information management, routine maintenance and special conservation & restoration, the evaluation and simulation of related disasters, such as earthquake. The research objects are ancient architectures in JIN-FEN area, which were first investigated by Sicheng LIANG and recorded in his work of “Chinese ancient architectures survey report”. The research objects, i.e. the ancient architectures in Jin-Fen area include those in Sicheng LIANG’s investigation, and further adjustments were made through authors’ on-site investigation and literature searching & collection. During this research process, the spatial distributing Geodatabase of research objects is established utilizing GIS. The BIM components library for ancient buildings is formed combining on-site investigation data and precedent classic works, such as “Yingzao Fashi”, a treatise on architectural methods in Song Dynasty, “Yongle Encyclopedia” and “Gongcheng Zuofa Zeli”, case collections of engineering practice, by the Ministry of Construction of Qing Dynasty. A building of Guangsheng temple in Hongtong county is selected as an example to elaborate the BIM model construction process based on the BIM components library for ancient buildings. Based on the foregoing work results of spatial distribution data, attribute data of features, 3D graphic information and parametric building information model, the information management system for ancient architectures in Jin-Fen Area, utilizing GIS&BIM technology, could be constructed to support the

One-loop renormalization of Lee-Wick gauge theory

International Nuclear Information System (INIS)

Grinstein, Benjamin; O'Connell, Donal

2008-01-01

We examine the renormalization of Lee-Wick gauge theory to one-loop order. We show that only knowledge of the wave function renormalization is necessary to determine the running couplings, anomalous dimensions, and vector boson masses. In particular, the logarithmic running of the Lee-Wick vector boson mass is exactly related to the running of the coupling. In the case of an asymptotically free theory, the vector boson mass runs to infinity in the ultraviolet. Thus, the UV fixed point of the pure gauge theory is an ordinary quantum field theory. We find that the coupling runs more quickly in Lee-Wick gauge theory than in ordinary gauge theory, so the Lee-Wick standard model does not naturally unify at any scale. Finally, we present results on the beta function of more general theories containing dimension six operators which differ from previous results in the literature.

Wrong vertex displacements due to Lee-Wick resonances at LHC

International Nuclear Information System (INIS)

Alvarez, E.; Schat, C.; Rold, L. da; Szynkman, A.

2009-01-01

We show how a resonance from the recently proposed Lee-Wick Standard Model could lead to wrong vertex displacements at LHCb. We study which could be the possible 'longest lived' Lee-Wick particle that could be created at LHC, and we study its possible decays and detections. We conclude that there is a region in the parameter space which would give wrong vertex displacements as a unique signature of the Lee-Wick Standard Model at LHCb. Further numerical simulation shows that LHC era could explore these wrong vertex displacements through Lee-Wick leptons below 500 GeV. (author)

Retrospective: Ivy Lee and the German Dye Trust.

Science.gov (United States)

Hainsworth, Brad E.

1987-01-01

Examines the relationship between public relations trailblazer Ivy Lee and the German Dye Trust, which became an agent for the policies of Adolf Hitler. Discusses how Lee's efforts to use this relationship to persuade his contacts to influence the Nazi leadership failed because of his formal connection with this group. (JD)

Die brein soos beskou deur die Grieke en Romeine

Directory of Open Access Journals (Sweden)

Francois P. Retief

2015-02-01

Full Text Available In Ou Egipte is mummifikasie met uitgebreide reseksie of uitsnyding van organe geassosieer, maar geen kennis is geneem van die morfologie van die brein nie. Griekse skrywers van die sesde en vyfde eeue v.C. het die brein aanvanklik gesien as die setel van intelligensie, die orgaan van sensoriese waarneming en gedeeltelik die oorsprong van sperma. Pneuma het ’n belangrike rol in breinfunksie gespeel. Hippokrates was die eerste om die brein te beskryf as ’n dubbele orgaan, wat met harsingvlies (meninges bedek, funksioneel van pneuma afhanklik en vertolker van begrip is. Tydgenote soos Plato, Aristoteles en Diokles het tot die beskrywing bygedra, maar laasgenoemde twee het beweer dat die hart die middelpunt van intelligensie is en nie die brein nie. Gedurende die laaste helfte van die vierde eeu v.C. is disseksie van die menslike liggaam tydelik aan die mediese skool van Alexandrië toegelaat en het dit tot merkwaardige vooruitgang in die begrip van die menslike anatomie en fisiologie gelei. Herofilus en Erasistratus het uitstekende beskrywings van die struktuur en funksie van die brein gegee wat eers in die tweede eeu n.C. deur Galenus geëwenaar is.

Research of Ancient Architectures in Jin-Fen Area Based on GIS and BIM Technology

International Nuclear Information System (INIS)

Jia, Jing; Zheng, Qiuhong; Gao, Huiying; Sun, Hai

2017-01-01

The number of well-preserved ancient buildings located in Shanxi Province, enjoying the absolute maximum proportion of ancient architectures in China, is about 18418, among which, 9053 buildings have the structural style of wood frame. The value of the application of BIM (Building Information Modeling) and GIS (Geographic Information System) is gradually probed and testified in the corresponding fields of ancient architecture’s spatial distribution information management, routine maintenance and special conservation and restoration, the evaluation and simulation of related disasters, such as earthquake. The research objects are ancient architectures in JIN-FEN area, which were first investigated by Sicheng LIANG and recorded in his work of “Chinese ancient architectures survey report”. The research objects, i.e. the ancient architectures in Jin-Fen area include those in Sicheng LIANG’s investigation, and further adjustments were made through authors’ on-site investigation and literature searching and collection. During this research process, the spatial distributing Geodatabase of research objects is established utilizing GIS. The BIM components library for ancient buildings is formed combining on-site investigation data and precedent classic works, such as “Yingzao Fashi”, a treatise on architectural methods in Song Dynasty, “Yongle Encyclopedia” and “Gongcheng Zuofa Zeli”, case collections of engineering practice, by the Ministry of Construction of Qing Dynasty. A building of Guangsheng temple in Hongtong county is selected as an example to elaborate the BIM model construction process based on the BIM components library for ancient buildings. Based on the foregoing work results of spatial distribution data, attribute data of features, 3D graphic information and parametric building information model, the information management system for ancient architectures in Jin-Fen Area, utilizing GIS and BIM technology, could be constructed to support

Enhanced therapeutic efficacy of budesonide in experimental colitis with enzyme/pH dual-sensitive polymeric nanoparticles

Directory of Open Access Journals (Sweden)

Naeem M

2015-07-01

Full Text Available Muhammad Naeem, Jiafu Cao, Moonjeong Choi, Woo Seong Kim, Hyung Ryong Moon, Bok Luel Lee, Min-Soo Kim, Yunjin Jung, Jin-Wook Yoo College of Pharmacy, Pusan National University, Busan, South Korea Abstract: Current colon-targeted drug-delivery approaches for colitis therapy often utilize single pH-triggered systems, which are less reliable due to the variation of gut pH in individuals and in disease conditions. Herein, we prepared budesonide-loaded dual-sensitive nanoparticles using enzyme-sensitive azo-polyurethane and pH-sensitive methacrylate copolymer for the treatment of colitis. The therapeutic potential of the enzyme/pH dual-sensitive nanoparticles was evaluated using a rat colitis model and compared to single pH-triggered nanoparticles. Clinical activity scores, colon/body weight ratios, myeloperoxidase activity, and proinflammatory cytokine levels were markedly decreased by dual-sensitive nanoparticles compared to single pH-triggered nanoparticles and budesonide solution. Moreover, dual-sensitive nanoparticles accumulated selectively in inflamed segments of the colon. In addition, dual-sensitive nanoparticle plasma concentrations were lower than single pH-triggered nanoparticles, and no noticeable in vitro or in vivo toxicity was observed. Our results demonstrate that enzyme/pH dual-sensitive nanoparticles are an effective and safe colon-targeted delivery system for colitis therapy. Keywords: azo-polyurethane, methacrylate copolymer, budesonide, colon-targeted nanoparticles, colitis

Development of a chitosan based double layer-coated tablet as a platform for colon-specific drug delivery

Directory of Open Access Journals (Sweden)

Kim MS

2016-12-01

Full Text Available Min Soo Kim,1,* Dong Woo Yeom,1,* Sung Rae Kim,1 Ho Yub Yoon,1 Chang Hyun Kim,1 Ho Yong Son,1 Jin Han Kim,1 Sangkil Lee,2 Young Wook Choi1 1College of Pharmacy, Chung-Ang University, Seoul, 2College of Pharmacy, Keimyung University, Daegu, South Korea *These authors contributed equally to this work Abstract: A double layer-coated colon-specific drug delivery system (DL-CDDS was developed, which consisted of chitosan (CTN based polymeric subcoating of the core tablet containing citric acid for microclimate acidification, followed by an enteric coating. The polymeric composition ratio of Eudragit E100 and ethyl cellulose and amount of subcoating were optimized using a two-level factorial design method. Drug-release characteristics in terms of dissolution efficiency and controlled-release duration were evaluated in various dissolution media, such as simulated colonic fluid in the presence or absence of CTNase. Microflora activation and a stepwise mechanism for drug release were postulated. Consequently, the optimized DL-CDDS showed drug release in a controlled manner by inhibiting drug release in the stomach and intestine, but releasing the drug gradually in the colon (approximately 40% at 10 hours and 92% at 24 hours in CTNase-supplemented simulated colonic fluid, indicating its feasibility as a novel platform for CDD. Keywords: chitosan, colon-specific delivery, acidification, microflora, factorial design, controlled release

Radiology examination as a diagnostic aid in presentations with ...

African Journals Online (AJOL)

Radiology examination as a diagnostic aid in presentations with wide differential diagnoses: Case report of new Hodgkin's lymphoma on a background of poorly controlled HIV. Rachel Hubbard, Jalpa Kotecha, Thomas Nash, Yu Jin Lee, Nasir Khan, Farhat Kazmi ...

Baikov-Lee representations of cut Feynman integrals

International Nuclear Information System (INIS)

Harley, Mark; Moriello, Francesco; Schabinger, Robert M.

2017-01-01

We develop a general framework for the evaluation of d-dimensional cut Feynman integrals based on the Baikov-Lee representation of purely-virtual Feynman integrals. We implement the generalized Cutkosky cutting rule using Cauchy’s residue theorem and identify a set of constraints which determine the integration domain. The method applies equally well to Feynman integrals with a unitarity cut in a single kinematic channel and to maximally-cut Feynman integrals. Our cut Baikov-Lee representation reproduces the expected relation between cuts and discontinuities in a given kinematic channel and furthermore makes the dependence on the kinematic variables manifest from the beginning. By combining the Baikov-Lee representation of maximally-cut Feynman integrals and the properties of periods of algebraic curves, we are able to obtain complete solution sets for the homogeneous differential equations satisfied by Feynman integrals which go beyond multiple polylogarithms. We apply our formalism to the direct evaluation of a number of interesting cut Feynman integrals.

Even a monkey can understand fan activism: Political speech, artistic expression, and a public for the Japanese dôjin community

Directory of Open Access Journals (Sweden)

Alex Leavitt

2012-06-01

Full Text Available We examine the creation of dôjinshi works critiquing the passage of the metropolitan Tokyo ordinance Bill 156 in December 2010 as a case of fan-driven political activism. Bill 156 aims to limit artistic freedom and is specifically targeted at anime, manga, and other works of visual pop culture. Fans who participate in dôjin production perform both a love for this media and an active form of citizenship that is historically fannish but transformative beyond the mere appropriation and remix of media texts. We argue that dôjin fans and works constitute a recursive public, wherein participants actively create discourse around artistic and ideological issues while engaging in added layers of discourse regarding the maintenance of their existence as a public. We examine fan discourse and dôjin works engaging Bill 156 as an object for political activism, as anime and manga otaku perform their citizenship in the wider society of Japan for their local public and for a global audience of like-minded fans.

TERT-CLPTM1 locus polymorphism (rs401681 is associated with the prognosis of hepatocellular carcinoma

Directory of Open Access Journals (Sweden)

Lee HW

2017-10-01

Full Text Available Hye Won Lee,1,* Won-Jin Park,2,* Yu-Ran Heo,2 Tae In Park,3 Soo Young Park,4 Jae-Ho Lee2,* 1Department of Pathology, Keimyung University School of Medicine, Daegu, Republic of Korea; 2Department of Anatomy, Keimyung University School of Medicine, Daegu, Republic of Korea; 3Department of Pathology, Kyungpook National University School of Medicine, Daegu, Republic of Korea; 4Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Republic of Korea *These authors contributed equally to this work Abstract: Telomere length is associated with the development of hepatocellular carcinoma (HCC, and recent studies have focused on the genetic alteration or polymorphism in telomere-maintaining genes. We examined the clinicopathologic and prognostic value of rs401681 polymorphism, located in the TERT-CLPTM1L locus, in HCC. The relationship between rs401681 variants and telomere length was also analyzed in 156 HCC patients. The rs401681 polymorphism had the following genotype frequencies: C/C in 51.3% of the samples, C/T in 39.7%, and T/T in 9.0%. Telomeres in the tumor samples were 4.04-fold longer, on average, than the telomeres in matched normal samples (SD =1.32, and there were no differences in telomere length according to rs401681 polymorphism (p=0.802. Our results indicate that the rs401681 C allele was significantly associated with increased T and International Union for Cancer Control stages (p<0.01. Univariate and multivariate survival analyses showed that HCC with C allele had poorer prognosis (p<0.01. In conclusion, our findings suggest that rs401681 is a possible prognostic biomarker for HCC patients. Keywords: CLPTM1L polymorphism, hepatocellular carcinoma, TERT-CLPTM1L locus, telomere length

Design of a novel theranostic nanomedicine: synthesis and physicochemical properties of a biocompatible polyphosphazene–platinum(II conjugate

Directory of Open Access Journals (Sweden)

Avaji PG

2016-03-01

Full Text Available Prakash G Avaji,1,2,* Jung Hyun Park,1,* Hyun Jeong Lee,1 Yong Joo Jun,2 Kyung Su Park,3 Kyung Eun Lee,3 Soo-Jin Choi,4 Hwa Jeong Lee,1 Youn Soo Sohn2 1Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Republic of Korea; 2C & Pharm, Ewha Womans University, Seoul, Republic of Korea; 3Advanced Analysis Center, Korea Institute of Science and Technology, Seoul, Republic of Korea; 4Department of Food Science and Technology, Seoul Women’s University, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: To develop a theranostic nanomedicine involving the antitumor-active moiety (dachPt(II (dach: trans-(±-1,2-diaminocyclohexane of oxaliplatin (OX, a new biocompatible polyphosphazene carrier polymer was designed by grafting with a methoxy poly(ethylene glycol (MPEG to increase duration of circulation in the blood and with aminoethanol (AE as a spacer group. The antitumor (dachPt moiety was conjugated to the carrier polymer using cis-aconitic acid (AA as a linker, resulting in a polymer conjugate formulated as [NP(MPEG550(AE-AAPt(dach]n, named “Polyplatin” (PP. PP was found to self-assemble into very stable polymeric nanoparticles with a mean diameter of 55.1 nm and a critical aggregation concentration of 18.5 mg/L in saline. PP could easily be labeled with a fluorescence dye such as Cy5.5 for imaging studies. The time-dependent ex vivo image studies on organ distributions and clearance of Cy-labeled PP have shown that PP accumulated in the tumor with high selectivity by the enhanced permeability and retention effect but was cleared out from all the major organs including the liver in about 4 weeks postinjection. Another time-dependent bioimaging study on distribution and clearance of PP in mouse kidney using laser ablation inductively coupled plasma mass spectroscopy has shown that PP accumulates much less in kidney and is more rapidly excreted than monomeric OX, which is in accord with the

The Measurement of Urbanization Level Based on Entity Space: A Case Study of JingJinJi Region, China

Directory of Open Access Journals (Sweden)

Wen Fenghua

2017-01-01

Full Text Available On the basis of analyzing the pros and cons of different urbanization level measurement methods, this paper puts forward urbanization level measurement method based on entity space and then uses entity space data to describe the urbanization rate of various districts and counties of JingJinJi Region in 2005 and 2009. According to the analysis of time and space differences on such basis, JingJinJi may be divided from high to low order according to the urbanization rate of the entity space: central urban area, urban development area and suburb, which respectively bear different functions. According to the comparison of entity space urbanization rate and population urbanization rate in the aspects of sequence, primacy ratio, zipf index, etc., we find the non-intensive land use status quo of urban development area of JingJinJi and the feature that the distribution of entity space urbanization scale is much uniform than distribution of population urbanization scale. Accordingly, the paper puts forward the following suggestions : (1 The space construction should depend upon function division; (2 The urban development area should pay attention to the construction of the supporting facilities and meanwhile enhance land use rate; (3 The urban construction should be enhanced in small and middle regions and counties surrounding Beijing and Tianjin.

An interview with Sandra C. Matherly and Shannon Hodges. Interview by Connie C. Curran.

Science.gov (United States)

Matherly, S C; Hodges, S

1995-01-01

Sandra C. Matherly, MA, RNC, FNP, is senior vice president, business development, and Shannon Hodges, MBA, is vice president, clinical development, Nurse On Call, Inc., Norcross, GA. Founded in 1993, Nurse on Call is a software and services company offering nursing, medical, and business expertise in setting up and operating a patient management unit using telecommunications and information systems. In this interview, Ms. Matherly and Ms. Hodges discuss the history and development of Nurse on Call, and offer advice for starting a successful nurse entrepreneur enterprise.

Thomas George Lee - Implantation and early development of North American rodents

DEFF Research Database (Denmark)

Carter, Anthony Michael

2011-01-01

A century ago Thomas G. Lee amassed an unparalleled collection of developmental series of North American rodents such as the thirteen-lined ground squirrel, the Plains pocket gopher and Merriam's kangaroo rat. He was the first to describe the initial attachment of the squirrel blastocyst to the a......A century ago Thomas G. Lee amassed an unparalleled collection of developmental series of North American rodents such as the thirteen-lined ground squirrel, the Plains pocket gopher and Merriam's kangaroo rat. He was the first to describe the initial attachment of the squirrel blastocyst...... to the antimesometrial side of the uterus. The full potential of Lee's material was not realized until after his death, when it came into the possession of Mossman. The latter relied heavily on Lee's collection when writing his seminal monograph on the comparative morphogenesis of fetal membranes and much of Lee...

Tim Berners-Lee and Kofi Annan during the WSIS

CERN Multimedia

Patrice Loïez

2003-01-01

During the 2003 World Summit on the Information Society (WSIS) at Geneva Palexpo, Tim Berners-Lee W3C's director (World Wide Web consortium) was introduced to Kofi Annan, Secretary General of the United Nations. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

Tim Berners-Lee and Kofi Annan during the WSIS

CERN Multimedia

Patrice Loïez

2003-01-01

During the 2003 World Summit on the Information Society (WSIS) at Geneva Palexpo, Tim Berners-Lee, W3C's director (World Wide Web consortium) was introduced to Kofi Annan, Secretary General of the United Nations. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

Deterministic and stochastic trends in the Lee-Carter mortality model

DEFF Research Database (Denmark)

Callot, Laurent; Haldrup, Niels; Kallestrup-Lamb, Malene

The Lee and Carter (1992) model assumes that the deterministic and stochastic time series dynamics loads with identical weights when describing the development of age specific mortality rates. Effectively this means that the main characteristics of the model simplifies to a random walk model...... that characterizes mortality data. We find empirical evidence that this feature of the Lee-Carter model overly restricts the system dynamics and we suggest to separate the deterministic and stochastic time series components at the benefit of improved fit and forecasting performance. In fact, we find...... that the classical Lee-Carter model will otherwise over estimate the reduction of mortality for the younger age groups and will under estimate the reduction of mortality for the older age groups. In practice, our recommendation means that the Lee-Carter model instead of a one-factor model should be formulated...

Lee de Forest King of Radio, Television, and Film

CERN Document Server

Adams, Mike

2012-01-01

Lee de Forest, Yale doctorate and Oscar winner, gave voice to the radio and the motion picture. Yet by the 1930s, after the radio and the Talkies were regular features of American life, Lee de Forest had seemingly lost everything. Why? Why didn’t he receive the recognition and acclaim he sought his entire life until years later in 1959, when he was awarded an Oscar? A lifelong innovator, Lee de Forest invented the three-element vacuum tube which he developed between 1906 and 1916 as a detector, amplifier, and oscillator of radio waves. As early as 1907, he was broadcasting music programming. In 1918, he began to develop a system for recording and playing back sound by using light patterns on motion picture film. In order to promote and demonstrate his process he made hundreds of short sound films, found theatres for their showing, and issued publicity to gain audiences for his invention. While he received many patents for this technology, he was ignored by the film industry. Lee de Forest, King of Radio, Te...

Dissecting and Targeting Latent Metastasis

Science.gov (United States)

2014-09-01

Option in Brain Metastasis Manuel Valiente,1 Anna C. Obenauf,1 Xin Jin,1 Qing Chen,1 Xiang H.-F. Zhang,1,8 Derek J. Lee,1 Jamie E. Chaft,2 Mark G. Kris,2...of poor response to tamoxifen therapy in recurrent breast cancer. J. Natl. Cancer Inst. 87, 751–756. Francia, G., Cruz -Munoz, W., Man, S., Xu, P... Manuel Valiente1, Xin Jin1†, Ekrem Emrah Er1, Ruzeen Patwa1, Ke Xu3 and Joan Massagué1 1 Cancer Biology and Genetics Program, 2 Department of

[Evaluation on efficacy of Jin's "Sanzhen" therapy combined with rehabilitation training for hemiplegia of stroke patients by Fugl-Meyer scale].

Science.gov (United States)

Han, De-Xiong; Zhuang, Li-Xing; Zhang, Ying

2011-06-01

To assess the therapeutic effect of Jin's "Sanzhen" therapy combined with rehabilitation training on limb-motor function of stroke patients by using Fugl-Meyer scale. A total of 254 hemiplegic stroke outpatients and inpatients from 7 hospitals were randomly divided into Jin's "Sanzhen" (JSZ) group (n = 83), rehabilitation group (n = 84) and combination group (n = 87). Acupuncture was applied to acupoints of Jin's "Sanzhen" including Quchi (LI 11), Waiguan (SJ 5) and Hegu (LI 4); Futu (ST 32). Zusanli (ST 36) and Sanyinjiao (SP 6); etc. The acupuncture needles were retained for 30 min after "Deqi". Rehabilitation training included passive joint movement, standing-sitting training, tapping-pressing stimulation, walking training, etc. The treatment was conducted once daily, 5 sessions a week and for 4 weeks. Fugl-Meyer scale composed of 100-point motor domain of the upper- and lower-extremity sections was used to assess the patients' motor function. On day 28 after the treatment, of the 83.84 and 87 hemiplegic stroke patients in the JSZ, rehabilitation and combination groups, 48 (57.8%), 31 (36.9%) and 50 (57.5%) experienced marked improvement in their clinical symptoms and signs, 26 (31.3%), 44 (52.4%) and 31(35.6%) had an improvement, and 9 (10.8%), 9 (10.7%) and 6 (6.9%) failed in the treatment, with the total effective rates being 89.2%, 89.3% and 93.1%, respectively. The neurological deficit score (NDS) of the combination group was significantly lower than that of the rehabilitation group (P rehabilitation groups (P rehabilitation groups in both NDS and FMAS (P > 0.05). Jin's "Sanzhen" therapy combined with rehabilitation training can significantly improve the limb motor function of hemiplegic stroke patients, and has a good synergistic effect.

Manumycin from a new Streptomyces strain shows antagonistic ...

African Journals Online (AJOL)

Manumycin from a new Streptomyces strain shows antagonistic effect against methicillin-resistant Staphylococcus aureus (MRSA)/vancomycin-resistant enterococci (VRE) strains from Korean Hospitals. Yun Hee Choi, Seung Sik Cho, Jaya Ram Simkhada, Chi Nam Seong, Hyo Jeong Lee, Hong Seop Moon, Jin Cheol Yoo ...

DsRed gene expression by doxycycline in porcine fibroblasts and ...

African Journals Online (AJOL)

DsRed gene expression by doxycycline in porcine fibroblasts and cloned embryos using transposon. SuJin Kim, JoonHo Moon, BegoRoibas da Torre, Islam M Saadeldin, JungTaek Kang, JiYei Choi, SolJi Park, Byeong-Chun Lee, Goo Jang Goo Jang ...

Fluorinated Materials for Air-stable and Moisture-resistant Flexible Optoelectronics

Science.gov (United States)

2014-01-02

Kim Jong , H.; Shin, S.; Yang, H.; An, B.-K.; Yang, L.; Park Soo, Y. Adv Mater 2012, 24, 911-915; (c) Geng, Y.; Li, H.-B.; Wu, S.-X.; Su, Z.-M. J...Park, J.-U.; Shir, D. J.-L.; Nam , Y.-S.; Jeon, S.; Rogers, J. A. Chem. Rev. 2007, 107, 1117-1160; (g) Murphy, A. R.; Frechet, J. M. J. Chem. Rev. 2007...2649-2655; (w) Song, H.-J.; Kim , D.-H.; Lee, E.-J.; Heo, S.-W.; Lee, J.-Y.; Moon, D.-K. Macromolecules (Washington, DC, U. S.) 2012, 45, 7815- 7822; (x

Virginia Lee Burton's "Little House" in Popular Consciousness

DEFF Research Database (Denmark)

Goddard, Joseph

2011-01-01

This article considers the significance of Victoria Lee Burton’s authorship, specifically The Little House, for lifestyle preferences and the development of environmental consciousness in the postwar period. The article argues that Burton deliberately designed her work to evoke country-friendly s......This article considers the significance of Victoria Lee Burton’s authorship, specifically The Little House, for lifestyle preferences and the development of environmental consciousness in the postwar period. The article argues that Burton deliberately designed her work to evoke country...

Delphine Letort, The Spike Lee Brand: A Study of Documentary Filmmaking

OpenAIRE

Lipson, David

2017-01-01

Spike Lee is known the world over for films like She’s Gotta Have It (1986), School Daze (1988), Do the Right Thing (1989), etc. This association with fiction films is so strong that one could mistakenly think that Delphine Letort’s book The Spike Lee Brand: A Study of Documentary Filmmaking would explore the connection between these fiction films and the documentary genre. However, the first pages of the book clearly indicate that it will focus on Spike Lee the documentary filmmaker. Making ...

E. S. M ulder . Ds. S. H oekstra , Het Boek Leviticus. J. H . Kok, N. V. ...

African Journals Online (AJOL)

Test

14:10 lees ons van een volkomen schaap van een jaar oud, Hoekstra omskryf dit as een een-jarig vrouwtjesschaap, die N.B.G. een eenjarige gave ooi. Soms kry ons minder juiste omskrywings b.v. in Lev. 26:13, waar sprake is nie van die verbreking van die juk soos die skrywer wil nie, maar van die jukskeie. Die inhoud ...

[The medical theory of Lee Je-ma and its character].

Science.gov (United States)

Lee, Kyung-Lock

2005-12-01

Lee Je-ma 1837-1900) was a prominent scholar as well as an Korean physician. classified every people into four distinctive types: greater yang [tai yang] person, lesser yin [shao yin] person, greater yin [tai yin] person, lesser yin [shao yin] person. This theory would dictate proper treatment for each type in accordance with individual differences of physical and temperament features. Using these four types he created The Medical Science of Four Types. This article is intended to look into the connection between Lee Je-Ma's 'The Medical Science of Four Types' and 'The Modern' with organizing his ideas about the human body and the human being. Through The Modern, the theory of human being underwent a complete change. Human being in The Premodern, which was determined by sex, age and social status has been changed to the individual human being, which is featured by equality. Lee Je-Ma's medical theory of The Medical Science of Four Types would be analyzed as follow. His concept of human body is oriented toward observable objectivity. But on the other hand, it still remains transcendent status of medical science, which is subordinated by philosophy. According to Lee Je-Ma's theory of human being, human is an equal individual in a modern way of thinking, not as a part of hierarchical group. But on the other hand, it still remains incomplete from getting rid of morality aspect that includes virtue and vice in the concept of human body. The common factors in Lee Je-Ma's ideas about the human body and the human being is 'Dualism of mind and body that means all kinds of status and results depends on each individual. As is stated above, Lee Je-Ma's medical theory has many aspects of The Modern and it proves that Korean traditional medicine could be modernized by itself.

Heidegger and the source of meaning | Knowles | South African ...

African Journals Online (AJOL)

Sandra Lee Bartky criticises the account of meaning contained in Heidegger's ontology in Being and Time. In her view, Heidegger must choose between the claim that meaning is received and the claim that it is created, but is unable to do so. This paper argues that Bartky's criticism is misconceived, by showing that ...

The Impact of Land Use and Land Cover Change on Water Yield in the Jing- Jin-Ji Region in China

Science.gov (United States)

Li, Suxiao; Yang, Hong

2017-04-01

Water yield is one of the key ecosystem services sustaining both people's life and economic development. However, the water yield function is sensitive to anthropogenic activity especially the land use and land cover change (LUCC). Assessment of historical LUCC and its impact on water yield could benefit designing and implementing appropriate land use strategy that enhance the water yield capacity. Beijing (Jing) and its surrounding areas of Tianjin (Jin) and Hebei (Ji) is the political, cultural and economic center of China. The region is facing increasingly water crisis. Taking the Jing-Jin-Ji region as a study area, this study analyzed the historical LUCC and its impact on water yield by using the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) model to spatially map and quantify the changes of water yield from 1995 to 2010. The results showed there was main decline in area of wetland and forest and increase in area of crop land and built up land. An abrupt decline in water yield was found for year 2000. The water yield was influenced to a great extent by precipitation and evapotranspiration, but the land use played an important role in the water yield capacity (water yield per unit area) through plant cover that affected evapotranspiration, soil water permeability and the capacity of holding the moisture content. By general ranking, the water yield capacity of different land use type was as follows: built-up>bare land>cropland> grassland>forest >wetland, which illustrated that the built-up and bare land had higher run off rate while the vegetation area had higher capacity to control surface run off to increase the groundwater. A good understanding of temporal-spatial allocation of historical LUCC and Water yield of the Jing-Jin-Ji region could help guide land use policy decisions that take into consideration of tradeoffs with respect to spatial distribution of ecosystem services amongst the three administrative entities (Jing-Jin-Ji) and

Comparative steady-state pharmacokinetic study of an extended-release formulation of itopride and its immediate-release reference formulation in healthy volunteers

OpenAIRE

Yoon, Seonghae; Lee, Howard; Kim, Tae-Eun; Lee, SeungHwan; Chee, Dong-Hyun; Cho, Joo-Youn; Yu, Kyung-Sang; Jang, In-Jin

2014-01-01

Seonghae Yoon,1,* Howard Lee,2,* Tae-Eun Kim,1 SeungHwan Lee,1 Dong-Hyun Chee,3 Joo-Youn Cho,1 Kyung-Sang Yu,1 In-Jin Jang1 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 2Clinical Trials Center, Seoul National University Hospital, 3AbbVie Ltd., Seoul, Republic of Korea *These authors contributed equally to this work Background: This study was conducted to compare the oral bioavailability of an itopride extended-release (ER...

Targeting Biological Sensing with Commercial SERS Substrates

Science.gov (United States)

2012-09-01

substrate substrate. Sl x 4 mm waf urement to re ossible contam substrates, fiv resented as an e being used f tigated, and nam eived in an ac cations...targeted nanotechnology-based inhalation co-delivery of anticancer drugs and siRNA," Journal of Drug Targeting, 900-914 (2011). [35] Jong , H.J., Na...J.H., Jin, B.S., Lee, W.K., Lee, W.H., Jung, H.J., Kim , S.C., Lim, S.H., Yu, Y.G., "Identification of Dinitrotoluene Selective Peptides by Phage

Optimization of biohydrogen production from beer lees using anaerobic mixed bacteria

Energy Technology Data Exchange (ETDEWEB)

Cui, Maojin; Yuan, Zhuliang; Zhi, Xiaohua; Shen, Jianquan [Beijing National Laboratory for Molecular Sciences (BNLMS), Laboratory of New Materials, Institute of Chemistry, Chinese Academy of Sciences, Zhongguancun North First Street 2, Beijing 100190 (China)

2009-10-15

Beer lees are the main by-product of the brewing industry. Biohydrogen production from beer lees using anaerobic mixed bacteria was investigated in this study, and the effects of acidic pretreatment, initial pH value and ferrous iron concentration on hydrogen production were studied at 35 C in batch experiments. The hydrogen yield was significantly enhanced by optimizing environmental factors such as hydrochloric acid (HCl) pretreatment of substrate, initial pH value and ferrous iron concentration. The optimal environmental factors of substrate pretreated with 2% HCl, pH = 7.0 and 113.67 mg/l Fe{sup 2+} were observed. A maximum cumulative hydrogen yield of 53.03 ml/g-dry beer lees was achieved, which was approximately 17-fold greater than that in raw beer lees. In addition, the degradation efficiency of the total reducing sugar, and the contents of hemicellulose, cellulose, lignin and metabolites are presented, which showed a strong dependence on the environmental factors. (author)

Awards: New Year Knighthood for Tim Berners-Lee

CERN Multimedia

2004-01-01

Tim Berners-Lee has been awarded his country's highest honour - a knighthood - in the UK's New Year Honours list for his work while at CERN on the World Wide Web. In the same honours list, Roger Cashmore has been made a Companion of the Order of St Michael and St George (CMG) "for his services to international co-operation in particle physics". Cashmore was CERN's Director for Collider Programmes from 1999-2003, and is now Principal of Brasenose College, Oxford. Tim Berners-Lee stands in front of the first web server at Palexpo during the World Summit on the Information Society.

Spotlight on nano-theranostics in South Korea: applications in diagnostics and treatment of diseases

Directory of Open Access Journals (Sweden)

Lee S

2015-08-01

Full Text Available Sangwha Lee,1,* Jongsung Kim,1,* Chung Wung Bark,2 Bonghee Lee,3 Heongkyu Ju,4 Se Chan Kang,5 TaeYoung Kim,6 Moon Il Kim,6 Young Tag Ko,3 Jeong-Seok Nam,3 Hyon Hee Yoon,1 Kyu-Sik Yun,1,6 Young Soo Yoon,1 Seong Soo A An,1,6 John Hulme6 1BioNano Sensor Research Center, 2Department of Electrical Engineering, Gachon University, Seongnam-si, 3Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, 4Department of Nano-Physics, 5Department of Life Science, Gachon University, 6Department of BioNano Technology, Gachon BioNano Research Institute, Seongnam-si, South Korea *These authors contributed equally to this work Abstract: From the synergistic integration and the multidisciplinary strengths of the BioNano Sensor Research Center, Gachon Bionano Research Institute, and Lee GilYa Cancer and Diabetes Institute, researchers, students, and faculties at Gachon University in collaboration with other institutions in Korea, Australia, France, America, and Japan have come together to produce a special issue on the diverse applications of nano-theranostics in nanomedicine. This special issue will showcase new research conducted by various scientific groups in Gyonggi-do and Songdo/Incheon, South Korea. The objectives of this special issue are as follows: 1 to bring together and demonstrate some of the latest research results in the field, 2 to introduce new multifunctional nanomaterials and their applications in imaging and detection methods, and 3 to stimulate collaborative interdisciplinary research at both national and international levels in nanomedicine. Keywords: cancer, imaging and therapeutics, antibacterial, disease, neurodegenerative

Lee-Nauenberg theorem and Coulomb scattering

Energy Technology Data Exchange (ETDEWEB)

Fleming, H; Frenkel, J [Sao Paulo Univ. (Brazil). Instituto de Fisica

1975-08-01

Lee-Nauenberg analysis is extended to the case of Coulomb scattering, where the diagonal elements of the Hamiltonian interaction are singular functions. It is shown, using a simple argument, that the leading infrared singularities in the cross-section are mutually canceled out.

The Use of Nontreated Mosquito‑Net Mesh Cloth for a Tension Free ...

African Journals Online (AJOL)

Wideochir Inne Tech Malo. Inwazyjne 2013;8:36‑42. 15. Taylor EW, Duffy K, Lee K, Hill R, Noone A, Macintyre I, et al. Surgical site infection after groin hernia repair. Br J Surg. 2004;91:105‑11. 16. Tongaonkar RR, Sandra DL, Kingsnorth AN. Ten year personal experience of using Low Density Polyethylene (LDPE) mesh for.

Grain-size sorting in grainflows at the lee side of deltas

NARCIS (Netherlands)

Kleinhans, M.G.

2005-01-01

The sorting of sediment mixtures at the lee slope of deltas (at the angle of repose) is studied with experiments in a narrow, deep flume with subaqueous Gilbert-type deltas using varied flow conditions and different sediment mixtures. Sediment deposition and sorting on the lee slope of the delta

Targeting CD81 to Prevent Metastases in Breast Cancer

Science.gov (United States)

2015-10-01

height) and/or by bioluminescence using the in vivo optical imaging system ( IVIS 100, Xenogen). Mice were sacrificed when s.c. tumor size reached 2...Hong IK, Byun HJ, Lee J, Jin YJ, Wang SJ, Jeoung DI, et al. The tetraspanin CD81 protein increases melanoma cell motility by up-regulating

The medical theory of Lee Je-ma and its character

Directory of Open Access Journals (Sweden)

LEE Kyung-Lock

2005-12-01

Full Text Available Lee Je-ma(李濟馬, 1837-1900 was a prominent scholar as well as an Korean physician He classified every people into four distinctive types: greater yang[tai yang] person, lesser yin[shao yin] person greater yin[tai yin] person, lesser yin[shao yin] person. This theory would dictate proper treatment for each type in accordance with individual differences of physical and temperament features Using these four types he created The Medical Science of Four Types(四象體質論.This article is intended to look into the connection between Lee Je-Ma's 'The Medical Science of Four Types' and 'The Modern' with organizing his ideas about the human body and the human being. Through The Modern, the theory of human being(人間觀 underwent a complete change. Human being in The Premodern, which was determined by sex, age and social status has been changed to the individual human being, which is featured by equality. Lee Je-Ma's medical theory of The Medical Science of Four Types would be analyzed as follow. His concept of human body(人體論 is oriented toward observable objectivity. But on the other hand, it still remains transcendent status of medical science, which is subordinated by philosophy According to Lee Je-Ma's theory of human being human is an equal individual in a modern way of thinking not as a part of hierarchical group. But on the other hand, it still remains incomplete from getting rid of morality aspect that includes virtue and vice in the concept of human body.The common factors in Lee Je-Ma's ideas about the human body and the human being is 'Dualism of mind and body(心身二元論' that means all kinds of status and results depends on each individual. As is stated above, Lee Je-Ma's medical theory has many aspects of The Modern and it proves that Korean traditional medicine could be modernized by itself.

Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy

OpenAIRE

Oh, Keun Sang; Kim, Kyungim; Yoon, Byeong Deok; Lee, Hye Jin; Park, Dal Yong; Kim, Eun-yeong; Lee, Kiho; Seo, Jae Hong; Yuk, Soon Hong

2016-01-01

Keun Sang Oh,1,* Kyungim Kim,1,* Byeong Deok Yoon,1 Hye Jin Lee,1 Dal Yong Park,1 Eun-yeong Kim,1 Kiho Lee,1 Jae Hong Seo,2 Soon Hong Yuk1,2 1College of Pharmacy, Korea University, Sejong, 2Biomedical Research Center, Korea University Guro Hospital, Guro-gu, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: A mixture of docetaxel (DTX) and Solutol® HS 15 (Solutol) transiently formed nanodroplets when it was suspended in an aqueous medium. However, n...

Tim Berners-Lee at the RSIS conference from 8-9 December 2003.

CERN Multimedia

Patrice Loiez

2003-01-01

Tim Berners-Lee participated in the Role of Science in the Information Society conference held at CERN from 8-9 December 2003. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

Subordinations In “To Kill A Mockingbird” By Harper Lee

OpenAIRE

Siregar, Rut Sri Novitawaty

2011-01-01

Salah satu yang dipelajari mahasiswa adalah tulis menulis. Secara ilmiah tulis menulis adalah penyampaian informasi dalam bentuk tulisan serta bagaimana informasi itu disampaikan. Judul kertas karya ini adalah Kalimat Subordinat yang ditemukan dalam novel To Kill a Mockingbird karya Harper Lee: SUBORDINATION IN TO KILL A MOCKINGBIRD BY HARPER LEE. Penulis mengangkat hal ini karena penulis tertarik dengan bentuk–bentuk serta fungsi-fungsi kalimat subordinat yang terdapat dalam tulisan-tulisan ...

Instability of the Lee-Wick bounce

International Nuclear Information System (INIS)

Karouby, Johanna; Brandenberger, Robert; Qiu, Taotao

2011-01-01

It was recently realized [Y. F. Cai, T. t. Qiu, R. Brandenberger, and X. m. Zhang, Phys. Rev. D 80, 023511 (2009).] that a model constructed from a Lee-Wick type scalar field theory yields, at the level of homogeneous and isotropic background cosmology, a bouncing cosmology. However, bouncing cosmologies induced by pressureless matter are in general unstable to the addition of relativistic matter (i.e. radiation). Here we study the possibility of obtaining a bouncing cosmology if we add radiation coupled to the Lee-Wick scalar field. This coupling in principle would allow the energy to flow from radiation to matter, thus providing a drain for the radiation energy. However, we find that it takes an extremely unlikely fine-tuning of the initial phases of the field configurations for a sufficient amount of radiative energy to flow into matter. For general initial conditions, the evolution leads to a singularity rather than a smooth bounce.

Lee waves, benign and malignant

Science.gov (United States)

Wurtele, M. G.; Datta, A.

1992-01-01

The flow of an incompressible, stratified fluid over an obstacle will produce an oscillation in which buoyancy is the restoring force, called a gravity wave. For disturbances of this scale, the atmosphere may be treated as incompressible; and even the linear approximation will explain many of the phenomena observed in the lee of mountains. However, nonlinearities arise in two ways: (1) through the large (scaled) size of the mountain, and (2) from dynamically singular levels in the fluid field. These produce a complicated array of phenomena that present hazards to aircraft and to lee surface areas. If there is no dynamic barrier, these waves can penetrate vertically into the middle atmosphere (30-100 km attitude), where recent observations show them to be of a length scale that must involve the Coriolis force in any modeling. At these altitudes, the amplitude of the waves is very large, and the waves are studied with a view to their potential impact on the projected National Aerospace Plane. This paper presents the results of analyses and state-of-the-art numerical simulations, validated where possible by observational data.

Expression of porcine myosin heavy chain 1 gene in Berkshire loins ...

African Journals Online (AJOL)

Expression of porcine myosin heavy chain 1 gene in Berkshire loins with a high pH24 value. Jin Hun Kang, Woo Young Bang, Eun Jung Kwon, Yong Hwa Lee, Da Hye Park, Eun Seok Cho, Min Ji Kim, Jong-Soon Choi, Hwa Chun Park, Beom Young Park, Chul Wook Kim ...

The Statecraft of Singapore's Lee Kuan Yew

National Research Council Canada - National Science Library

Toh, K

1996-01-01

.... The ejection of Singapore from the Federation led Lee to focus on two strategic goals: the survival of Singapore as an independent state while simultaneously pursuing nation-building under the threats of communism and internal ethnic conflicts...

Compound mitochondrial DNA mutations in a neurological patient ...

Indian Academy of Sciences (India)

Compound mitochondrial DNA mutations in a neurological patient with ataxia, myoclonus and deafness. Ji Hoon Park, Bo Ram Yoon, Hye Jin Kim, Phil Hyu Lee, Byung-Ok Choi and Ki Wha Chung. J. Genet. 93, 173–177. Table 1. Variations from the whole mtDNA sequence in the AMDF patient. Mutation. Report. Locus/ ...

Sandra Boehringer, L'Homosexualité féminine dans l'Antiquité grecque et romaine

Directory of Open Access Journals (Sweden)

Rostom Mesli

2008-07-01

Full Text Available La publication de L’Homosexualité féminine dans l’Antiquité grecque et romaine de Sandra Boehringer est, à plusieurs titres, une excellente nouvelle.Sur le plan universitaire et éditorial, d’abord, ce livre vient confirmer qu’après de longues années de chape de plomb, les départements de lettres classiques et d’histoire ancienne sont en train de s’ouvrir aux recherches sur la sexualité. L’université française ne s’est mise – c’est le moins que l’on puisse dire – que très lentement aux recherc...

Triniti daripada Perspektif Taoisme: Analisis Pemikiran Jung Young Lee

Directory of Open Access Journals (Sweden)

ZURAIZA HUSIN

2016-06-01

Full Text Available Jung Young Lee is a Korean-born theologian who employs creatively the doctrine of the Trinity from an Asian worldview. This article aims to analyze Lee’s approaches of the Trinity with the Yin-Yang symbolism. The main reference is based on the book written by him entitled ‘The Trinity in Asian Perspective (1996’. Lee has turned his attention to the topic of Trinity through the lens of the culture and thought patterns of his own milieu. One of the leading point in presenting Yin-Yang principle as Trinitarian thinking, Lee examines the interpretation of the term “in” in the Bible, "Believe me that I am in the Father and the Father is in me" (John 14:11. The statement leads to the point that Yin and Yang cannot exist without each other because relationality is given priority than individuality. The idea is based on the terminology of ‘both/and’. So, ‘and’ indicates a Trinitarian statement, there is interdependence and unification. With reference to Trinity, the Father and the Son are One because of ‘and’. In addition, the same concept implements to the Holy Spirit. Lee views ‘and’ is not only a linking principle in both-and thinking but also the principle that is ‘between’ two. When ‘two’ exists, the third also exist between them. Based on the idea of ‘middle’, represents the connecting element between two, which contributes for the existence of the Third. Accordingly, the Spirit is the third element in the Trinity relationship.

The impact of the "Air Pollution Prevention and Control Action Plan" on PM2.5 concentrations in Jing-Jin-Ji region during 2012-2020.

Science.gov (United States)

Cai, Siyi; Wang, Yangjun; Zhao, Bin; Wang, Shuxiao; Chang, Xing; Hao, Jiming

2017-02-15

In order to cope with heavy haze pollution in China, the Air Pollution Prevention and Control Action Plan including phased goals of the fine particulate matter (PM 2.5 ) was issued in 2013. In this study, China's emission inventories in the baseline 2012 and the future scenarios of 2017 and 2020 have been developed based on this Action Plan. Beijing-Tianjin-Hebei (Jing-Jin-Ji) region, one of the most polluted regions in China, was taken as a case to assess the impact of phased emission control measures on PM 2.5 concentration reduction using WRF-CMAQ model system. With the implementation of the Action Plan, the emissions of sulfur dioxide (SO 2 ), nitrogen oxides (NO X ) , PM 2.5 , non-methane volatile organic compound (NMVOC), and ammonia (NH 3 ) in 2017 will decrease by36%, 31%, 30%,12%, and -10% from the 2012 levels in Jing-Jin-Ji, respectively. In 2020, the emissions of SO 2 , NO X, PM 2.5 , NMVOC, and NH 3 will decrease by 40%, 44%, 40%, 22%, and -3% from the 2012 levels in Jing-Jin-Ji, respectively. Consequently, the ambient annual PM 2.5 concentration under the scenarios of 2017 and 2020 will be 28.3% and 37.8% lower than those in 2012, respectively. The Action Plan provided an effective approach to alleviate PM 2.5 pollution level in Jing-Jin-Ji region. However, emission control of NMVOC and NH 3 should be paid more attention and be strengthened in future. Meanwhile, emission control of NO x , SO 2 , NH 3 and NMVOC synergistically are highly needed in the future because multiple pollutants impact on PM 2.5 and O 3 concentrations nonlinearly. Copyright © 2016 Elsevier B.V. All rights reserved.

Comparative genomics and stx phage characterization of LEE-negative Shiga toxin-producing Escherichia coli

Directory of Open Access Journals (Sweden)

Susan Renee Steyert

2012-11-01

Full Text Available Infection by Escherichia coli and Shigella species are among the leading causes of death due to diarrheal disease in the world. Shiga toxin producing Escherichia coli (STEC that do not encode the locus of enterocyte effacement (LEE-negative STEC often possess Shiga toxin gene variants and have been isolated from humans and a variety of animal sources. In this study, we compare the genomes of nine LEE-negative STEC harboring various stx alleles with four complete reference LEE-positive STEC isolates. Compared to a representative collection of prototype E. coli and Shigella isolates representing each of the pathotypes, the whole genome phylogeny demonstrated that these isolates are diverse. Whole genome comparative analysis of the 13 genomes revealed that in addition to the absence of the LEE pathogenicity island, phage encoded genes including non-LEE encoded effectors, were absent from all nine LEE-negative STEC genomes. Several plasmid-encoded virulence factors reportedly identified in LEE-negative STEC isolates were identified in only a subset of the nine LEE-negative isolates further confirming the diversity of this group. In combination with whole genome analysis, we characterized the lambdoid phages harboring the various stx alleles and determined their genomic insertion sites. Although the integrase gene sequence corresponded with genomic location, it was not correlated with stx variant, further highlighting the mosaic nature of these phages. The transcription of these phages in different genomic backgrounds was examined. Expression of the Shiga toxin genes, stx1 and/or stx2, as well as the Q genes, were examined with quantitative reverse transcriptase polymerase chain reaction (qRT-PCR assays. A wide range of basal and induced toxin induction was observed. Overall, this is a first significant foray into the genome space of this unexplored group of emerging and divergent pathogens.

Practical Improvements to the Lee-More Conductivity Near the Metal-Insulator Transition

International Nuclear Information System (INIS)

Desjarlais, Michael P.

2000-01-01

The wide-range conductivity model of Lee and More is modified to allow better agreement with recent experimental data and theories for dense plasmas in the metal-insulator transition regime. Modifications primarily include a new ionization equilibrium model, consisting of a smooth blend between single ionization Saha (with a pressure ionization correction) and the generic Thomas-Fermi ionization equilibrium, a more accurate treatment of electron-neutral collisions using a polarization potential, and an empirical modification to the minimum allowed collision time. These simple modifications to the Lee-More algorithm permit a more accurate modeling of the physics near the metal-insulator transition, while preserving the generic Lee-More results elsewhere

Practical improvements to the Lee-More conductivity near the metal-insulator transition

International Nuclear Information System (INIS)

Desjarlais, M.P.

2001-01-01

The wide-range conductivity model of Lee and More is modified to allow better agreement with recent experimental data and theories for dense plasmas in the metal-insulator transition regime. Modifications primarily include a new ionization equilibrium model, consisting of a smooth blend between single ionization Saha (with a pressure ionization correction) and the generic Thomas-Fermi ionization equilibrium, a more accurate treatment of electron-neutral collisions using a polarization potential, and an empirical modification to the minimum allowed collision time. These simple modifications to the Lee-More algorithm permit a more accurate modeling of the physics near the metal-insulator transition, while preserving the generic Lee-More results elsewhere. (orig.)

Effectiveness of Traditional Chinese Medicine Compound JieDuTongLuoShengJin Granules Treatment in Primary Sjögren’s Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Directory of Open Access Journals (Sweden)

Ben Li

2017-01-01

Full Text Available Objective. To evaluate the clinical therapeutic efficacy and safety of JieDuTongLuoShengJin granules + HCQ in patients with pSS. Methods. 40 patients with low-activity-level pSS and without visceral involvement participated in this study and were randomized to receive either JieDuTongLuoShengJin granules with HCQ or placebo with HCQ. Patients and investigators were blinded to treatment allocation. The primary endpoint was week 12 ESSPRI score, while secondary endpoints included ESSDAI, salivary and lacrimal gland function, and some laboratory variables. Safety-related data were also assessed. Results. Comparing with the placebo group, the treatment group experienced statistically significant improvement in the mean change from baseline for the primary endpoint of ESSPRI score and also in PGA. Moreover, in comparison with baseline values, the treatment group had significantly improved ESSDAI score, unstimulated saliva flow rate, and several laboratory variables. However, upon comparison of the two groups, there were no significant differences for them. The incidence of AEs was 10.0%, one in treatment group and three in placebo group. Conclusion. Treatment with a combination of JieDuTongLuoShengJin granules with HCQ is effective in improving patients’ subjective symptoms and some objective indicators of pSS. These results indicate that JieDuTongLuoShengJin is promising as a safe and effective treatment of pSS.

Tim Berners-Lee, World Wide Web inventor

CERN Multimedia

1998-01-01

The "Internet, Web, What's next?" conference on 26 June 1998 at CERN: Tim Berners-Lee, inventor of the World Wide Web and Director of the W3C, explains how the Web came to be and gave his views on the future.

Alternative implementation of the chaotic Chen-Lee system

International Nuclear Information System (INIS)

Sheu, L.-J.; Tam, L.-M.; Chen, H.-K.; Lao, S.-K.

2009-01-01

The chaotic Chen-Lee system was developed with a formalism based on the Euler equations for the motion of a rigid body. It was proved that this system is the governing set of equations for gyro motion with feedback control. Recently, studies were conducted to explore the dynamic behavior of this system, including fractional order behavior, the generation of hyperchaos and perturbation analysis, control and anti-control of chaos, synchronization, etc. In this study, we further explore (1) the stability of the equilibrium points and (2) the implementation of an electronic circuit using the Chen-Lee system. It is shown that not only is this system related to gyro motion but can also be applied to electronic circuits for encryption purposes.

Courtland Lee: A Global Advocate for Counseling

Science.gov (United States)

Gladding, Samuel T.

2011-01-01

Courtland Lee is exemplary in his accomplishments nationally and internationally. His academic achievements are notable in multicultural counseling and social justice. His leadership in counseling has been outstanding with his having served as president of the American Counseling Association, the Association for Multicultural Counseling and…

Consumption-based Total Suspended Particulate Matter Emissions in Jing-Jin-Ji Area of China

Science.gov (United States)

Yang, S.; Chen, S.; Chen, B.

2014-12-01

The highly-industrialized regions in China have been facing a serious problem of haze mainly consisted of total suspended particulate matter (TSPM), which has attracted great attention from the public since it directly impairs human health and clinically increases the risks of various respiratory and pulmonary diseases. In this paper, we set up a multi-regional input-output (MRIO) model to analyze the transferring routes of TSPM emissions between regions through trades. TSPM emission from particulate source regions and sectors are identified by analyzing the embodied TSPM flows through monetary flow and carbon footprint. The track of TSPM from origin to end via consumption activities are also revealed by tracing the product supply chain associated with the TSPM emissions. Beijing-Tianjin-Hebei (Jing-Jin-Ji) as the most industrialized area of China is selected for a case study. The result shows that over 70% of TSPM emissions associated with goods consumed in Beijing and Tianjin occurred outside of their own administrative boundaries, implying that Beijing and Tianjin are net embodied TSPM importers. Meanwhile, 63% of the total TSPM emissions in Hebei Province are resulted from the outside demand, indicating Hebei is a net exporter. In addition, nearly half of TSPM emissions are the by-products related to electricity and heating supply and non-metal mineral products in Jing-Jin-Ji Area. Based on the model results, we provided new insights into establishing systemic strategies and identifying mitigation priorities to stem TSPM emissions in China. Keywords: total suspended particulate matter (TSPM); urban ecosystem modeling; multi-regional input-output (MRIO); China

Nooruslikud juubilarid: fotokelder Lee 20 ja fotomuuseum 30 / Mall Parmas, Betty Ester-Väljaots

Index Scriptorium Estoniae

Parmas, Mall

2013-01-01

Peeter Toominga algatusel 1992. aastal asutatud Lee fotokeldrist. Loetletud fotomuuseumis oma töid eksponeerinud fotograafid. Ülevaatenäitus "Lee fotokelder 20" 17. jaanuarist 20. märtsini, koostaja Betty Ester-Väljaots

Synchronization and anti-synchronization coexist in Chen-Lee chaotic systems

International Nuclear Information System (INIS)

Chen, J.-H.; Chen, H.-K.; Lin, Y.-K.

2009-01-01

This study demonstrates that synchronization and anti-synchronization can coexist in Chen-Lee chaotic systems by direct linear coupling. Based on Lyapunov's direct method, a linear controller was designed to assure that two different types of synchronization can simultaneously be achieved. Further, the hybrid projective synchronization of Chen-Lee chaotic systems was studied using a nonlinear control scheme. The nonlinear controller was designed according to the Lyapunov stability theory to guarantee the hybrid projective synchronization, including synchronization, anti-synchronization, and projective synchronization. Finally, numerical examples are presented in order to illustrate the proposed synchronization approach.

Economist Innovation Award for Tim Berners-Lee

CERN Multimedia

2003-01-01

In September, Tim Berners-Lee, who invented the World Wide Web at CERN and is now Director of the W3C World Wide Web Consortium, received the 2nd Economist Annual Innovation Award in Computing. With the award The Economist, a British weekly newspaper, recognises individuals responsible for breakthroughs in Bioscience, Computing, Energy and the Environment, and Telecommunications that have a profound impact on industry. A fifth award is given in a special "No Boundaries" category, observing innovation that transcends industries. Candidates for the awards are proposed by The Economist readers and writers, and by a group of judges. Tim Berners-Lee received the Computing award for his global hypertext project, to be known as the World Wide Web, which "forever altered the way information is shared" and is a huge contribution to the efficiency of the scientific community. Based on a programme for storing information using random associations called "Enquire", it...

[Lee Jungsook, a Korean independence activist and a nurse during the Japanese colonial period].

Science.gov (United States)

Kim, Sook Young

2015-04-01

This article examines the life of Lee Jungsook, a Korean nurse, as a independence activist during the Japanese colonial period. Lee Jungsook(1896-1950) was born in Bukchung in Hamnam province. She studied at Chungshin girl's high school and worked at Severance hospital. The characteristics and culture of her educational background and work place were very important factors which influenced greatly the life of Lee Jungsook. She learned independent spirit and nationalism from Chungshin girls' high school and worked as nurse at the Severance hospital which were full of intense aspiration for Korea's independence. Many of doctors, professors and medical students were participated in the 3.1 Independence Movement. Lee Jungsook was a founding member of Hyulsungdan who tried to help the independence activists in prison and their families and worked as a main member of Korean Women's Association for Korean Independece and Kyungsung branch of the Korean Red Cross. She was sent to jail by the Japanese government for her independence activism. After being released after serving two years confinement, she worked for the Union for Women's Liberation as a founding member. Lee Joungsook was a great independence activist who had a nursing care spirit as a nurse.

Test procedure for the Master-Lee and the modified Champion four inch hydraulic cutters

International Nuclear Information System (INIS)

Crystal, J.B.

1995-01-01

The Master-Lee and the modified Champion 4 Inch hydraulic cutters are being retested to gather and document information related to the following: determine if the Master-Lee cutters will cut the trunnions of an Aluminum fuel canister and a Stainless Steel fuel canister; determine if the Master-Lee cutters will cut 1 1/2 inch diameter fire hose; determine if the modified Champion 4 inch blade will cut sections of piping; and determine the effectiveness of the centering device for the Champion 4 Inch cutters. Determining the limitations of the hydraulic cutter will aid in the process of debris removal in the K-Basin. Based on a previous test, the cutters were returned to the manufacturer for modifications. The modifications to the Champion 4 Inch Cutter and further testing of the Master-Lee Cutter are the subjects of these feature tests

Parametric study of the fractional-order Chen-Lee system

International Nuclear Information System (INIS)

Tam, L.M.; Tou, W.M.S.

2008-01-01

The dynamics of fractional-order systems have attracted a great deal of attention in recent years. In this paper, the effects of parameter changes on the dynamics of the fractional-order Chen-Lee system were studied numerically. The parameter ranges used were relatively broad. The order used for the system was fixed at 2.7 (q 1 = q 2 = q 3 = 0.9). The system displays rich dynamic behaviors, such as a fixed point, periodic motion (including period-3 motion), chaotic motion, and transient chaos. The chaotic motion identified was validated by the confirmation of a positive Lyapunov exponent. Period-doubling routes to chaos in the fractional-order Chen-Lee system were also found

Lee Acculturation Dream Scale for Korean-American college students.

Science.gov (United States)

Lee, Sang Bok

2005-04-01

This study examined acculturation as represented in dream narratives of 165 Korean immigrant college students living in the USA. A total of 165 dreams were collected and evaluated using the Lee Acculturation Dream Scale, for which locations of dream contents were coded. 39% of the dreams took place in South Korea, while 38% were in the USA. Also, 16% of the dreams included both locations, whereas 7% had no specific dream location. The dreams contained overlapping dream messages, images, scenes, and interactions in both South Korea and the USA. A two-sample t test on the mean scores of the Lee Acculturation Dream Scale indicated no significant difference between men and women.

Parametric study of the fractional-order Chen-Lee system

Energy Technology Data Exchange (ETDEWEB)

Tam, L.M. [Department of Electromechanical Engineering, Faculty of Science and Technology, University of Macau, Av. Padre Tomas Pereira S.J., Taipa, Macau (China)], E-mail: fstlmt@umac.mo; Tou, W.M.S. [Department of Electromechanical Engineering, Faculty of Science and Technology, University of Macau, Av. Padre Tomas Pereira S.J., Taipa, Macau (China)

2008-08-15

The dynamics of fractional-order systems have attracted a great deal of attention in recent years. In this paper, the effects of parameter changes on the dynamics of the fractional-order Chen-Lee system were studied numerically. The parameter ranges used were relatively broad. The order used for the system was fixed at 2.7 (q{sub 1} = q{sub 2} = q{sub 3} = 0.9). The system displays rich dynamic behaviors, such as a fixed point, periodic motion (including period-3 motion), chaotic motion, and transient chaos. The chaotic motion identified was validated by the confirmation of a positive Lyapunov exponent. Period-doubling routes to chaos in the fractional-order Chen-Lee system were also found.

Pro-lipogenic Action of Lysophosphatidic Acid in Ovarian Cancer

Science.gov (United States)

2014-04-01

Function. IUBMB Life. 2008. 60: 347-354. 11. Tse C, Shoemaker AR, Adickes J, Anderson MG, Chen J, Jin S, Johnson EF, Marsh KC , Mitten MJ, Nimmer P...Ann. Oncol. 9, 437–442 14. Choi, J. W., Herr, D. R., Noguchi, K., Yung, Y. C., Lee, C. W., Mutoh, T., Lin, M. E., Teo , S. T., Park, K. E., Mosley, A

Isoeugenol monooxygenase and its putative regulatory gene are located in the eugenol metabolic gene cluster in Pseudomonas nitroreducens Jin1.

Science.gov (United States)

Ryu, Ji-Young; Seo, Jiyoung; Unno, Tatsuya; Ahn, Joong-Hoon; Yan, Tao; Sadowsky, Michael J; Hur, Hor-Gil

2010-03-01

The plant-derived phenylpropanoids eugenol and isoeugenol have been proposed as useful precursors for the production of natural vanillin. Genes involved in the metabolism of eugenol and isoeugenol were clustered in region of about a 30 kb of Pseudomonas nitroreducens Jin1. Two of the 23 ORFs in this region, ORFs 26 (iemR) and 27 (iem), were predicted to be involved in the conversion of isoeugenol to vanillin. The deduced amino acid sequence of isoeugenol monooxygenase (Iem) of strain Jin1 had 81.4% identity to isoeugenol monooxygenase from Pseudomonas putida IE27, which also transforms isoeugenol to vanillin. Iem was expressed in E. coli BL21(DE3) and was found to lead to isoeugenol to vanillin transformation. Deletion and cloning analyses indicated that the gene iemR, located upstream of iem, is required for expression of iem in the presence of isoeugenol, suggesting it to be the iem regulatory gene. Reverse transcription, real-time PCR analyses indicated that the genes involved in the metabolism of eugenol and isoeugenol were differently induced by isoeugenol, eugenol, and vanillin.

Pear distillates from pear juice concentrate: effect of lees in the aromatic composition.

Science.gov (United States)

García-Llobodanin, L; Achaerandio, I; Ferrando, M; Güell, C; López, F

2007-05-02

Pear juice obtained from pear concentrate was fermented at room temperature using Saccharomyces cerevisiae (BDX, ENOFERM, France) as the fermentation microorganism. During the fermentation process, total sugars were measured. High performance liquid chromatography analyses were used to monitor the fermentation process and to characterize the pear wine. The pear wine obtained was distilled with its lees using three different equipments: a glass alembic (a glass pot still coupled to a glass column), a copper alembic, and a glass alembic with the addition of 5 g/L of copper shavings to the pot still. The same distillations were repeated with the wine without its lees (separated by decanting). Several distillation fractions were collected, up to a total of 500 mL of distillate. Gas chromatography was used to identify and quantify the volatile compounds in each fraction, and the methanol and ethanol contents. Based on these results, the heart fraction was defined. ANOVA tests were performed on the heart fractions to determine quantitative differences between some volatile compounds depending on the equipment used and the presence or absence of the wine lees. From this series of ANOVA tests, it can be concluded that the concentrations of the compounds that are considered to have a negative effect on the quality of the distillates (methanol, ethyl acetate, furfural) decrease or do not change when they are distilled in the presence of lees and in the copper alembic. In addition, the concentrations of the positive compounds (ethyl decanoate and ethyl-2-trans-4-cis-decadienoate) increase in the presence of lees for all of the equipment tested. So, it can be assumed that the distillation of pear wine with its lees in copper alembic leads to a better quality product.

Berners-Lee wins inaugural Millennium Technology prize

CERN Document Server

2004-01-01

"World Wide Web inventor Tim Berners-Lee today was named recipient of the first-ever Millennium Technology Prize. The honor, which is accompanied by one million euros, is bestowed by the Finnish Technology Award Foundation as an international acknowledgement of outstanding technological innovation aimed at promoting quality of life and sustainable economic and societal development" (1 page)

Dan Gilmor Column [Berners-Lee and the WWW

CERN Multimedia

Gillmore, D

2002-01-01

In the keynote speech at the 11th Annual World Wide Web Conference, Tim Berner's Lee said that in the early days of the web, people were worrying about the same thing as today - one company dominating the market and controlling standards (2 pages).

The Statecraft of Lee Kuan Yew, Visionary and Opportunist

National Research Council Canada - National Science Library

Thomas, David

1996-01-01

...." "Not so," replied the passenger, Lee Kuan Yew, "Singapore intends to continue to ride along as part of the federation created with Malaysia, Sarawak, and Sabah -- we have no plans for getting off...

Iklan Sebagai Media Kritik Sosial (Pesan Simbolik Iklan Kretek Djarum 76 Seri Jin

Directory of Open Access Journals (Sweden)

Firdaus Azwar Ersyad

2016-04-01

Full Text Available The presence of television advertising is a prayer one way to manufacturer for review introduce and selling products for society. Regarding the regulation of advertising especially cigarettes and tobacco products manufacturer in order to encourage creative hearts introducing more on audience their product . As a result , the creativity in the hearts smoking ads aimed lifting product image so not operate direct products display .Singer study originated from the interest against visualization advertisements Djarum 76 series java jin  has its own peculiarities compared to other products . Zoom the one consolation is not revealed that an advertiser is selling products . Views are interpreted by different groups various ad viewers, but the views can be grouped into some basic ideas

General Robert E. Lee -- Brightest Star in the South

National Research Council Canada - National Science Library

Dalton, Kent B

2006-01-01

.... Lee's distinctive application of operational art and leadership as the commander of the Army of Northern Virginia, we can discern many lessons which are still pertinent to our commanders at the operational level today...

[Status of diagnosis and treatment devices of acupuncture based on SooPAT and bibliometrics in China].

Science.gov (United States)

Bai, Lin; Ren, Yulan; Guo, Taipin; Chen, Lin; Zhou, Yumei; Feng, Shuwei; Li, Ji; Liang, Fanrong

2016-11-12

To perform a bibliometrics analysis on patent literature regarding diagnosis and treatment devices of acupuncture in China, aiming to provide references for the development of diagnosis and treatment devices of acupuncture. Based on SooPAT, a patent database, the patent literature regarding diagnosis and treatment devices of acupuncture in China was collected. With bibliometrics methods, the annual distribution of type, quantity, classification and content of diagnosis and treatment devices of acupuncture were analyzed. The number of acupuncture diagnosis and treatment devices reached its peak in 2012 and 2013 in China. The A61N in patent and utility model patent were the most, which were mainly related to electrotherapy, magnetic therapy, radioactive therapy and ultrasound therapy, etc. The main content was acupuncture treatment devices and meridian treatment devices. The 24-01 in design patent was the most, involving fixation devices used by doctors, hospitals and laboratories, etc. Currently the majority of diagnosis and treatment devices of acupuncture is therapeutic apparatus, while the acupuncture diagnosis devices are needed.

Observation of Mountain Lee Waves with MODIS NIR Column Water Vapor

Science.gov (United States)

Lyapustin, A.; Alexander, M. J.; Ott, L.; Molod, A.; Holben, B.; Susskind, J.; Wang, Y.

2014-01-01

Mountain lee waves have been previously observed in data from the Moderate Resolution Imaging Spectroradiometer (MODIS) "water vapor" 6.7 micrometers channel which has a typical peak sensitivity at 550 hPa in the free troposphere. This paper reports the first observation of mountain waves generated by the Appalachian Mountains in the MODIS total column water vapor (CWV) product derived from near-infrared (NIR) (0.94 micrometers) measurements, which indicate perturbations very close to the surface. The CWV waves are usually observed during spring and late fall or some summer days with low to moderate CWV (below is approx. 2 cm). The observed lee waves display wavelengths from3-4 to 15kmwith an amplitude of variation often comparable to is approx. 50-70% of the total CWV. Since the bulk of atmospheric water vapor is confined to the boundary layer, this indicates that the impact of thesewaves extends deep into the boundary layer, and these may be the lowest level signatures of mountain lee waves presently detected by remote sensing over the land.

Potential of lees from wine, beer and cider manufacturing as a source of economic nutrients: An overview.

Science.gov (United States)

Pérez-Bibbins, B; Torrado-Agrasar, A; Salgado, J M; Oliveira, R Pinheiro de Souza; Domínguez, J M

2015-06-01

Lees are the wastes generated during the fermentation and aging processes of different industrial activities concerning alcoholic drinks such as wine, cider and beer. They must be conveniently treated to avoid uncontrolled dumping which causes environmental problems due to their high content of phenols, pesticides, heavy metals, and considerable concentrations of nitrogen, phosphate and potassium as well as high organic content. The companies involved must seek alternative environmental and economic physicochemical and biological treatments for their revalorization consisting in the recovery or transformation of the components of the lees into high value-added compounds. After describing the composition of lees and market of wine, beer and cider industries in Spain, this work aims to review the recent applications of wine, beer and cider lees reported in literature, with special attention to the use of lees as an endless sustainable source of nutrients and the production of yeast extract by autolysis or cell disruption. Lees and/or yeast extract can be used as nutritional supplements with potential exploitation in the biotechnological industry for the production of natural compounds such as xylitol, organic acids, and biosurfactants, among others. Copyright © 2015 Elsevier Ltd. All rights reserved.

Biokinetics of zinc oxide nanoparticles: toxicokinetics, biological fates, and protein interaction

Directory of Open Access Journals (Sweden)

Choi SJ

2014-12-01

Full Text Available Soo-Jin Choi,1 Jin-Ho Choy2 1Department of Food Science and Technology, Seoul Women's University, 2Center for Intelligent Nano Bio Materials (CINBM, Department of Bioinspired Science and Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, South Korea Abstract: Biokinetic studies of zinc oxide (ZnO nanoparticles involve systematic and quantitative analyses of absorption, distribution, metabolism, and excretion in plasma and tissues of whole animals after exposure. A full understanding of the biokinetics provides basic information about nanoparticle entry into systemic circulation, target organs of accumulation and toxicity, and elimination time, which is important for predicting the long-term toxic potential of nanoparticles. Biokinetic behaviors can be dependent on physicochemical properties, dissolution property in biological fluids, and nanoparticle–protein interaction. Moreover, the determination of biological fates of ZnO nanoparticles in the systemic circulation and tissues is critical in interpreting biokinetic behaviors and predicting toxicity potential as well as mechanism. This review focuses on physicochemical factors affecting the biokinetics of ZnO nanoparticles, in concert with understanding bioavailable fates and their interaction with proteins. Keywords: ZnO nanoparticles, biokinetics, distribution, excretion, fate, interaction

Quantization of the Lee static model by the Bogolyubov transformation method

International Nuclear Information System (INIS)

Bornyakov, V.G.

1984-01-01

The Lee static strong-coupling model is studied. The model permits to find an exact solution for the state vector of the system and for the scattering matrix in the first permanent order of expansion in the inverse value of the coupling constant. The Bogolyubov method has been applied to quantize the Lee model with a hamiltonian, provided a high classical constituent of a boson field exists. Ground state of the system and scattering matrix from the obtained bound state are found. The way to avoid additional zero modes arising at Bogolyubov transformation for creation and annihilation operators is shown

Co-ordinate single-cell expression of LEE4- and LEE5-encoded proteins of Escherichia coli O157:H7.

Science.gov (United States)

Roe, Andrew J; Naylor, Stuart W; Spears, Kevin J; Yull, Helen M; Dransfield, Tracy A; Oxford, Matthew; McKendrick, Iain J; Porter, Megan; Woodward, Martin J; Smith, David G E; Gally, David L

2004-10-01

Escherichia coli O157:H7 is a zoonotic pathogen that can express a type III secretion system (TTSS) considered important for colonization and persistence in ruminants. E. coli O157:H7 strains have been shown to vary markedly in levels of protein secreted using the TTSS and this study has confirmed that a high secretion phenotype is more prevalent among isolates associated with human disease than isolates shed by healthy cattle. The variation in secretion levels is a consequence of heterogeneous expression, being dependent on the proportion of bacteria in a population that are actively engaged in protein secretion. This was demonstrated by indirect immunofluorescence and eGFP fusions that examined the expression of locus of enterocyte effacement (LEE)-encoded factors in individual bacteria. In liquid media, the expression of EspA, tir::egfp, intimin, but not map::egfp were co-ordinated in a subpopulation of bacteria. In contrast to E. coli O157:H7, expression of tir::egfp in EPEC E2348/69 was equivalent in all bacteria although the same fusion exhibited variable expression when transformed into an E. coli O157:H7 background. An E. coli O157:H7 strain deleted for the LEE demonstrated weak but variable expression of tir::egfp indicating that the elements controlling the heterogeneous expression lie outside the LEE. The research also demonstrated the rapid induction of tir::egfp and map::egfp on contact with bovine epithelial cells. This control in E. coli O157:H7 may be required to limit exposure of key surface antigens, EspA, Tir and intimin during colonization of cattle but allow their rapid production on contact with bovine gastrointestinal epithelium at the terminal rectum.

The Garrett Lee Smith Memorial Suicide Prevention Program

Science.gov (United States)

Goldston, David B.; Walrath, Christine M.; McKeon, Richard; Puddy, Richard W.; Lubell, Keri M.; Potter, Lloyd B.; Rodi, Michael S.

2010-01-01

In response to calls for greater efforts to reduce youth suicide, the Garrett Lee Smith (GLS) Memorial Act has provided funding for 68 state, territory, and tribal community grants, and 74 college campus grants for suicide prevention efforts. Suicide prevention activities supported by GLS grantees have included education, training programs…

INCA Modelling of the Lee System: strategies for the reduction of nitrogen loads

Directory of Open Access Journals (Sweden)

N. J. Flynn

2002-01-01

Full Text Available The Integrated Nitrogen Catchment model (INCA was applied successfully to simulate nitrogen concentrations in the River Lee, a northern tributary of the River Thames for 1995-1999. Leaching from urban and agricultural areas was found to control nitrogen dynamics in reaches unaffected by effluent discharges and abstractions; the occurrence of minimal flows resulted in an upward trend in nitrate concentration. Sewage treatment works (STW discharging into the River Lee raised nitrate concentrations substantially, a problem which was compounded by abstractions in the Lower Lee. The average concentration of nitrate (NO3 for the simulation period 1995-96 was 7.87 mg N l-1. Ammonium (NH4 concentrations were simulated less successfully. However, concentrations of ammonium rarely rose to levels which would be of environmental concern. Scenarios were run through INCA to assess strategies for the reduction of nitrate concentrations in the catchment. The conversion of arable land to ungrazed vegetation or to woodland would reduce nitrate concentrations substantially, whilst inclusion of riparian buffer strips would be unsuccessful in reducing nitrate loading. A 50% reduction in nitrate loading from Luton STW would result in a fall of up to 5 mg N l-1 in the reach directly affected (concentrations fell from maxima of 13 to 8 mg N l-1 , nearly a 40 % reduction, whilst a 20% reduction in abstractions would reduce maximum peaks in concentration in the lower Lee by up to 4 mg l-1 (from 17 to 13 mg N l-1, nearly a 25 % reduction,. Keywords: modelling, water quality, nitrogen, nitrate, ammonium, INCA, River Lee, River Thames, land-use.

Tim Berners-Lee: inventor de la World Wide Web

OpenAIRE

Universidad de Granada. Biblioteca

2015-01-01

El presente Cat??logo contiene la exposici??n organizada por la Biblioteca de la ETSIIT de la Universidad de Granada durante los meses de noviembre-diciembre de 2015 y titulada: "Tim Berners-Lee: inventor de la World Wide Web"

Forecasting selected specific age mortality rate of Malaysia by using Lee-Carter model

Science.gov (United States)

Shukri Kamaruddin, Halim; Ismail, Noriszura

2018-03-01

Observing mortality pattern and trend is an important subject for any country to maintain a good social-economy in the next projection years. The declining in mortality trend gives a good impression of what a government has done towards macro citizen in one nation. Selecting a particular mortality model can be a tricky based on the approached method adapting. Lee-Carter model is adapted because of its simplicity and reliability of the outcome results with approach of regression. Implementation of Lee-Carter in finding a fitted model and hence its projection has been used worldwide in most of mortality research in developed countries. This paper studies the mortality pattern of Malaysia in the past by using original model of Lee-Carter (1992) and hence its cross-sectional observation for a single age. The data is indexed by age of death and year of death from 1984 to 2012, in which are supplied by Department of Statistics Malaysia. The results are modelled by using RStudio and the keen analysis will focus on the trend and projection of mortality rate and age specific mortality rate in the future. This paper can be extended to different variants extensions of Lee-Carter or any stochastic mortality tool by using Malaysia mortality experience as a centre of the main issue.

BANGUNAN TINGGI MULTI FUNGSI SEBAGAI SINTESIS ARSITEKTUR DAN STRUKTUR Studi Analisis Jin Mao Tower Grand Hyatt Shanghai

Directory of Open Access Journals (Sweden)

Jimmy Priatman

2005-01-01

Full Text Available More than two decades, after the emerging of post- modern architecture, the split between construction technology and cultural expression in architecture appeared to become wider and wider. With the exception of a few "high-tech" buildings, the unity of art and applied science (technology in design seems facing challenges. It is interesting to see how fast and unexpectedly the situation has changed. Many factors and people played a role in this reversal, many new buildings demonstrate that utilitarian artifacts do not have to be oppressive to creativity but can evoke new innovation. One of the most significant contributors was JIN MAO TOWER at Shanghai, China. The paper analyses this building as a genuine synthesis of rational intelligence with art poetry that is still possible. Abstract in Bahasa Indonesia : Lebih dari dua dekade setelah timbulnya arsitektur pasca modern, pemisahan antara tekknologi konstruksi dan ekspresi kultural dalam arsitektur menjadi semakin lebar. Dengan perkecualian beberapa gedung "high-tech", kesatuan antara seni dan teknologi dalam tahap desain terlihat menghadapi tantangan tantangan. Tetapi menarik untuk diamati bahwa situasi telah berubah. Banyak faktor dan tokoh tokoh arsitek memegang peranan penting dalam perubahan ini, banyak bangunan bangunan baru mendemontrasikan bahwa artefak fungsionil tidak bearti menindas kreativitas namun dapat membangkitkan inovasi baru. Salah satu kontributor yang sangat penting adalah JIN MAO TOWER di Shanghai-China. Makalah ini membahas bangunan tersebut sebagai sintesis orijinal yang masih memungkinkan antara kecerdasan rasional dengan puisi seni arsitektur. Kata kunci: Sintesis.

Relation between the Lee-Wick and Nambu-Jona-Lasinio models of chiral symmetry breaking

International Nuclear Information System (INIS)

Klevansky, S.P.; Lemmer, R.H.

1990-01-01

The connection between the sigma model of Lee and Wick and the Nambu-Jona-Lasinio (NJL) model is discussed. It is shown that the sigma field potential of the linear Lee-Wick model is identical in form with the variation of the vacuum energy of the NJL system with the baryonic scalar density n s . The sigma field is proportional to n s . Furthermore, the coupling constant and mass of this σ field are fully determined by the NJL model version of the Goldberger-Treiman relation. It is shown further that the restoration of chiral symmetry with increasing baryonic density always occurs via a second order transition in the NJL model, while it is necessarily of first order in the associated linear Lee-Wick model. (orig.)

Persistence of the longnose darter (P. nasuta) in Lee Creek, Oklahoma

Science.gov (United States)

Gatlin, Michael R.; Long, James M.

2011-01-01

The longnose darter Percina nasuta (Bailey) is one of Oklahoma’s rarest fish species (1) and is listed by the state as endangered. Throughout the rest of its range, which includes Missouri, Arkansas and the far eastern portion of Oklahoma, the longnose darter is classified as “rare” or “threatened” (2, 3, 4, 5, 6, 1). This species inhabits both slow- and fast-water habitats with cobble and gravel substrates in medium to large streams (7, 8, 1). Oklahoma populations of longnose darter are known to occur only in the Poteau River and Lee Creek drainages in Le Flore and Sequoyah counties, respectively (9, 10). Cross and Moore (9) collected longnose darters from the Poteau River in 1947. The species was not collected in a subsequent survey of the Poteau River in 1974 (11), possibly because of the effects from the Wister Dam, which was completed in 1949. Darters are especially susceptible to flow alterations from dams (2, 12). This, together with the 1992 completion of Lee Creek Reservoir in Arkansas, has raised concern for the Lee Creek population of longnose darters (13).

W3C head Berners-Lee to be knighted

CERN Multimedia

Gross, G

2004-01-01

"Tim Berners-Lee, credited with inventing the World Wide Web and now director of the World Wide Web Consortium, will be named a knight commander, Order of the British Empire, by Queen Elizabeth II, the W3C announced Wednesday" (1 page)

T.D Lee and Lisa Randall visit ATLAS

CERN Multimedia

Pauline Gagnon

Professor Tsung-Dao Lee, who received the Nobel Prize for Physics in 1957 for postulating that parity is not conserved in weak interactions, visited the ATLAS detector this month. He is seen here in the company of Peter Jenni, spokesperson for ATLAS. T.D. Lee is still very active at over 80, pursuing his theory work to this day. Professor Lisa Randall from Harvard University, the well-known theorist behind the Randall-Sundrum theory for extra dimensions, was also part of the group visiting the ATLAS detector. She is seen here with Fabiola Gianotti, deputy spokesperson for ATLAS. Lisa Randall's two initial papers have been quoted both more than 2500 times, making her the most cited theoretical physicist in the world in the last five years as of last autumn - a total of about 10,000 citations! One wonders here if Peter is pointing to a CP-violating graviton spotted in the ATLAS cavern... From left to right: Fabiola Gianotti, Gustaaf Brooijmans, convener of the ATLAS Exotics physics gro...

Ultra-Sensitive Biological Detection via Nanoparticle-Based Magnetically Amplified Surface Plasmon Resonance (Mag-SPR) Techniques

Science.gov (United States)

2008-10-08

surfactant such as hexadecyltrimethyl ammonium bromide (CTMA). And also CTMA- polymethacrylic acid (PMA), CTMA-Polyglutamic acid were synthesized as reference...rich world of naturally occurring biomaterials probably none is more important and more fundamental than DNA (deoxyribonucleic acid ), the polymeric...deoxyribonucleic acid gate dielectric," Journal of Applied Physics, vol. 100, p. 024514, 2006. [3] C. H. Lee, E.-D. Do, Y.-W. Kwon, D.-H. Choi, J.-I. Jin

Feminist Refiguring of La Malinche in Sandra Cisneros’ Never Marry A Mexican

Directory of Open Access Journals (Sweden)

Dian Natalia Sutanto

2016-12-01

Full Text Available La Malinche, the mistress of Spanish conquistador Hernán Cortés, has evolved from a historical figure into Mexican national myth that connotes all the negative aspects of woman’s sexuality in Mexican and Mexican-American Culture. Sandra Cisneros in her Never Marry A Mexican reinterpretsLa Malinchein a more positive light and points out how women sexuality can be the site for women empowerment.By drawing on insights from feminist theories on motherhood, marriage, and incest taboo, this study identifies the way Cisneros revises the negative image of La Malinche as a dupe, passive and submissive mistress. This study identifies that Cisneros has created a strong protagonist character named Clemencia, who exerts her subjectivity and claims for her sexual agency totransgress patriarchal construction of woman passive sexuality, imposition of maternal identity as asexual mother and taboo on incestuous relationship. Cisneros’s La Malinche is no longer depicted as the victim duped by the patriarchy, but as the survivor who is able to preserve her sense of herself in the dominating patriarchal world.   DOI: https://doi.org/10.24071/llt.2015.180103

Yang-Lee zeros for a Potts model of helix-coil transition with nontrivial topology

International Nuclear Information System (INIS)

Ananikian, N.; Ananikyan, L.; Artuso, R.; Sargsyan, K.

2007-07-01

The Yang-Lee partition function zeros of the Q-state Potts model on a zigzag ladder are studied by a transfer-matrix approach. This Q-state model has a non-trivial topology induced by three-site interactions on a zigzag ladder and is proposed as a description of helix-coil transition in homo-polymers. The Yang-Lee zeros are associated to complex values of the solvent-related coupling constant K (magnetic field) and they are exactly derived for arbitrary values of the system parameters: Q, J (coupling constant of hydrogen binding) and temperature. It is shown that there is only a quasi-phase transition for all temperatures. The densities of the Yang-Lee zeros are singular at the edge singularity points and the critical exponent σ = -1/2. (author)

What Lee Raymond actually said in Beijing [15th WPC

International Nuclear Information System (INIS)

Raymond, Lee.

1997-01-01

When Lee Raymond, Chairman and Chief Executive Officer, Exxon Corporation gave this keynote address at the recent World Petroleum Congress in Beijing, he drew attention to the way economic growth alleviates poverty and to the close linkage between economic growth and energy use. He also drew attention to the weakness of the scientific evidence for climate change being caused by fossil fuel burning and his doubts about the wisdom of setting targets for the reduction of CO 2 emissions. At a press conference after the presentation Lee Raymond assented to the suggestion that the European oil companies have been hijacked by the environmentalists. Petroleum Review has reproduced the full text of the speech so that readers can judge for themselves the merits of the arguments and their likely impact on the Kyoto conference. (UK)

SDE and SPME Analysis of Flavor Compounds in Jin Xuan Oolong Tea.

Science.gov (United States)

Sheibani, Ershad; Duncan, Susan E; Kuhn, David D; Dietrich, Andrea M; O'Keefe, Sean F

2016-02-01

Simultaneous distillation-extraction (SDE) and solid phase micro extraction (SPME) are procedures used for the isolation of flavor compounds in foods. The purpose of this study was to optimize SDE conditions (solvent and time) and to compare SDE with SPME for the isolation of flavor compounds in Jin Xuan oolong tea using GC-MS and GC-O. The concentration of volatile compounds isolated with diethyl ether was higher (P < 0.05) than for dichloromethane and concentration was higher at 40 min (P < 0.05) than 20 or 60 min extractions. For SDE, 128 volatiles were identified using GC-MS and 45 aroma active compounds using GC-O. Trans-nerolidol was the most abundant compound in oolong tea. The number of volatiles identified using GC-MS was lower in SPME than SDE. For SPME, 59 volatiles and 41 aroma active compounds were identified. The composition of the volatiles isolated by the 2 methods differed considerably but provided complementary information. © 2016 Institute of Food Technologists®

Lee waves: Benign and malignant

Science.gov (United States)

Wurtele, M. G.; Datta, A.; Sharman, R. D.

1993-01-01

The flow of an incompressible fluid over an obstacle will produce an oscillation in which buoyancy is the restoring force, called a gravity wave. For disturbances of this scale, the atmosphere may be treated as dynamically incompressible, even though there exists a mean static upward density gradient. Even in the linear approximation - i.e., for small disturbances - this model explains a great many of the flow phenomena observed in the lee of mountains. However, nonlinearities do arise importantly, in three ways: (1) through amplification due to the decrease of mean density with height; (2) through the large (scaled) size of the obstacle, such as a mountain range; and (3) from dynamically singular levels in the fluid field. These effects produce a complicated array of phenomena - large departure of the streamlines from their equilibrium levels, high winds, generation of small scales, turbulence, etc. - that present hazards to aircraft and to lee surface areas. The nonlinear disturbances also interact with the larger-scale flow in such a manner as to impact global weather forecasts and the climatological momentum balance. If there is no dynamic barrier, these waves can penetrate vertically into the middle atmosphere (30-100 km), where recent observations show them to be of a length scale that must involve the coriolis force in any modeling. At these altitudes, the amplitude of the waves is very large, and the phenomena associated with these wave dynamics are being studied with a view to their potential impact on high performance aircraft, including the projected National Aerospace Plane (NASP). The presentation shows the results of analysis and of state-of-the-art numerical simulations, validated where possible by observational data, and illustrated with photographs from nature.

Polyphenols from Wine Lees as a Novel Functional Bioactive Compound in the Protection Against Oxidative Stress and Hyperlipidaemia

Directory of Open Access Journals (Sweden)

Irena Landeka Jurčević

2017-01-01

Full Text Available The study examines the potential of wine industry by-product, the lees, as a rich mixture of natural polyphenols, and its physiological potential to reduce postprandial metabolic and oxidative stress caused by a cholesterol-rich diet in in vivo model. Chemical analysis of wine lees showed that their total solid content was 94.2 %. Wine lees contained total phenols, total nonflavonoids and total flavonoids expressed in mg of gallic acid equivalents per 100 g of dry mass: 2316.6±37.9, 1332.5±51.1 and 984.1±28.2, respectively. The content of total anthocyanins expressed in mg of cyanidin-3-glucoside equivalents per 100 g of dry mass was 383.1±21.6. Antioxidant capacity of wine lees determined by the DPPH and FRAP methods and expressed in mM of Trolox equivalents per 100 g was 259.8±1.8 and 45.7±1.05, respectively. The experiment lasted 60 days using C57BL/6 mice divided in four groups: group 1 was fed normal diet and used as control, group 2 was fed normal diet with added wine lees, group 3 was fed high-cholesterol diet (HCD, i.e. normal diet with the addition of sunflower oil, and group 4 was fed HCD with wine lees. HCD increased serum total cholesterol (TC by 2.3-fold, triacylglycerol (TAG by 1.5-fold, low-density lipoprotein (LDL by 3.5-fold and liver malondialdehyde (MDA by 50 %, and reduced liver superoxide dismutase (SOD by 50 %, catalase (CAT by 30 % and glutathione (GSH by 17.5 % compared to control. Conversely, treatment with HCD and wine lees reduced TC and LDL up to 1.4 times more than with HCD only, with depletion of lipid peroxidation (MDA and restoration of SOD and CAT activities in liver, approximating values of the control. HDL levels were unaffected in any group. Serum transaminase activity showed no hepatotoxic properties in the treatment with lees alone. In the proposed model, wine lees as a rich polyphenol source could be a basis for functional food products without alcohol.

"Cairo must address the equity issue." Interview: Sandra Postel.

Science.gov (United States)

1994-01-01

Sandra Postel, of the Worldwatch Institute, believes that inequalities in consumption and income foster environmental degradation. The richest 20% are getting richer and consuming excessively. The bottom 20%, comprising about 1 billion people, are getting poorer and are degrading their environment in order to survive. Per capita availability of resources is continually being reduced. If there is a desire to improve the quality of life for the poorest segment of the world population, then the richest must forfeit something. Environmental taxation could reduce excessive consumption in general; this strategy would be the most efficient and useful. Taxes would be placed on pollution and resources in danger of depletion; income taxes could be reduced to balance the impact of increased taxes on the economy. Wealthy countries must make a renewed commitment to poverty alleviation and to realistic sustainable development. Aid budgets should no longer reflect military priorities or strategic objectives. Trade is clearly related to the environment and poverty, and these connections must be made publicly known. National and international trade policies must deal with poverty issues and not contribute to further environmental destruction. Eliminating debt problems is another problem in need of change. The World Bank and structural adjustment policies have not proved to be environmentally sound and have not benefitted the poor. Evaluation of programs is needed, and lending policies should reflect the growing awareness of the problems of the poor and environmental consequences. Consumption of energy, wood, paper, and water are all higher among industrialized wealthy countries. Technology needs to be applied to maximize resource use, and policies must reflect this commitment. Israel has set a good example with water consumption reduction through advanced technology.

Dynamical fragmentation of flux tubes in the Friedberg-Lee model

International Nuclear Information System (INIS)

Loh, S.; Greiner, C.; Mosel, U.; Thoma, M.H.

1997-01-01

We present two novel dynamical features of flux tubes in the Friedberg-Lee model. First the fusion of two (anti-)parallel flux tubes, where we extract a string-string interaction potential which has a qualitative similarity to the nucleon-nucleon potential in the Friedberg-Lee model obtained by Koepf et al. Furthermore we show the dynamical breakup of flux tubes via qq-particle production and the disintegration into mesons. We find, as a shortcoming of the present realization of the model, that the full dynamical transport approach presented in a previous publication fails to provide the disintegration mechanism in the semiclassical limit. Therefore, in addition, we present here a molecular dynamical approach for the motion of the quarks and show, as a first application, the space-time development of the quarks and their mean-fields for Lund-type string fragmentation processes. (orig.)

Intermittency and dynamical Lee-Yang zeros of open quantum systems.

Science.gov (United States)

Hickey, James M; Flindt, Christian; Garrahan, Juan P

2014-12-01

We use high-order cumulants to investigate the Lee-Yang zeros of generating functions of dynamical observables in open quantum systems. At long times the generating functions take on a large-deviation form with singularities of the associated cumulant generating functions-or dynamical free energies-signifying phase transitions in the ensemble of dynamical trajectories. We consider a driven three-level system as well as the dissipative Ising model. Both systems exhibit dynamical intermittency in the statistics of quantum jumps. From the short-time behavior of the dynamical Lee-Yang zeros, we identify critical values of the counting field which we attribute to the observed intermittency and dynamical phase coexistence. Furthermore, for the dissipative Ising model we construct a trajectory phase diagram and estimate the value of the transverse field where the stationary state changes from being ferromagnetic (inactive) to paramagnetic (active).

Tim Berners-Lee, World Wide Web inventor

CERN Multimedia

1994-01-01

Former physicist, Tim Berners-Lee invented the World Wide Web as an essential tool for high energy physics at CERN from 1989 to 1994. Together with a small team he conceived HTML, http, URLs, and put up the first server and the first 'what you see is what you get' browser and html editor. Tim is now Director of the Web Consortium W3C, the International Web standards body based at INRIA, MIT and Keio University.

Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy

Directory of Open Access Journals (Sweden)

Naeem M

2015-07-01

Full Text Available Muhammad Naeem,1 Moonjeong Choi,1 Jiafu Cao,1 Yujeong Lee,1 Muhammad Ikram,2 Sik Yoon,2 Jaewon Lee,1 Hyung Ryong Moon,1 Min-Soo Kim,1 Yunjin Jung,1 Jin-Wook Yoo11College of Pharmacy, Pusan National University, Busan, 2Pusan National University School of Medicine, Yangsan, South KoreaAbstract: Single pH-dependent drug delivery systems have been widely used for colon-targeted delivery, but their efficiency is often hampered by the variation in gut pH. To overcome the limitation of single pH-dependent delivery systems, in this study, we developed and evaluated the therapeutic potential of budesonide-loaded dual pH/time-dependent nanoparticles (NPs for the treatment of colitis. Eudragit FS30D was used as a pH-dependent polymer, and Eudragit RS100 as a time-dependent controlled release polymer. Single pH-dependent NPs (pH_NPs, single time-dependent NPs (Time_NPs, and dual pH/time-dependent NPs (pH/Time_NPs were prepared using the oil-in-water emulsion method. The physicochemical properties and drug release profiles of these NPs in gastrointestinal (GI tract conditions were investigated. The therapeutic potential and in vivo distribution of the NPs were evaluated in a dextran sulfate sodium (DSS-induced colitis mice model. The pH/Time_NPs prevented a burst drug release in acidic pH conditions and showed sustained release at a colonic pH. The in vivo distribution study in the mice GI tract demonstrated that pH/Time_NPs were more efficiently delivered to the inflamed colon than pH_NPs were. Compared to the single pH_NPs-treated group, the pH/Time_NPs-treated group showed increased body weight and colon length and markedly decreased disease activity index, colon weight/length ratios, histological damage, and inflammatory cell infiltration in colon tissue. Our results demonstrate that the dual pH/time-dependent NPs are an effective oral colon-targeted delivery system for colitis therapy.Keywords: colon-specific delivery, dual-sensitive delivery

Fundamental solution of bond pricing in the Ho-Lee stochastic interest rate model under the invariant criteria

Directory of Open Access Journals (Sweden)

Burhaneddin İzgi

2017-03-01

under the invariant criteria. We obtain transformations between Ho-Lee model with the corresponding linear (1 + 1 partial differential equation and the first Lie canonical form which is identical to the classical heat equation. These transformations help us to generate the fundamental solution for the Ho-Lee model with respect to the fundamental solution of the classical heat equation sense. Moreover, as a financial application of the Ho-Lee model, we choose the drift term from power functions and perform simulations via Milstein method. Furthermore, we obtain important results for the parameter calibration of the corresponding drift term by using the simulation results.

Duke Power's William Lee says INPO's purpose is solving industry problems, not educating the public

International Nuclear Information System (INIS)

Anon.

1984-01-01

Former Institute of Nuclear Power Operations (INPO) head, William Lee thinks that nuclear critics could misuse institute reports on investigations of nuclear plant construction and operation. If so, that would outweigh any public relations benefits of using the reports to inform and educate the public. Lee thinks the best way to gain public confidence is for the industry to perform well. The four-year-old institute was originally formed to improve operations, but recent problems with unfinished plants led to a system of construction audits. By offering guidance to companies building nuclear plants, INPO is meeting competition from utilities such as Duke Power, which is now marketing its expertise in designing and building plants. Lee emphasizes the importance of asking the right questions that will lead to quality control

Exposure–response model for sibutramine and placebo: suggestion for application to long-term weight-control drug development

Directory of Open Access Journals (Sweden)

Han S

2015-09-01

Full Text Available Seunghoon Han,1,2 Sangil Jeon,1,2 Taegon Hong,1,2 Jongtae Lee,1,2 Soo Hyeon Bae,1,2 Wan-su Park,1,2 Gab-jin Park,1,2 Sunil Youn,1,2 Doo Yeon Jang,1,2 Kyung-Soo Kim,3 Dong-Seok Yim1,2 1Department of Pharmacology, College of Medicine, The Catholic University of Korea, 2Pharmacometrics Institute for Practical Education and Training, 3Department of Family Medicine, Seoul St Mary’s Hospital, Seochogu, Seoul, Republic of KoreaAbstract: No wholly successful weight-control drugs have been developed to date, despite the tremendous demand. We present an exposure–response model of sibutramine mesylate that can be applied during clinical development of other weight-control drugs. Additionally, we provide a model-based evaluation of sibutramine efficacy. Data from a double-blind, randomized, placebo-controlled, multicenter study were used (N=120. Subjects in the treatment arm were initially given 8.37 mg sibutramine base daily, and those who lost <2 kg after 4 weeks’ treatment were escalated to 12.55 mg. The duration of treatment was 24 weeks. Drug concentration and body weight were measured predose and at 4 weeks, 8 weeks, and 24 weeks after treatment initiation. Exposure and response to sibutramine, including the placebo effect, were modeled using NONMEM 7.2. An asymptotic model approaching the final body weight was chosen to describe the time course of weight loss. Extent of weight loss was described successfully using a sigmoidal exposure–response relationship of the drug with a constant placebo effect in each individual. The placebo effect was influenced by subjects’ sex and baseline body mass index. Maximal weight loss was predicted to occur around 1 year after treatment initiation. The difference in mean weight loss between the sibutramine (daily 12.55 mg and placebo groups was predicted to be 4.5% in a simulation of 1 year of treatment, with considerable overlap of prediction intervals. Our exposure–response model, which

Deterministic and stochastic trends in the Lee-Carter mortality model

DEFF Research Database (Denmark)

Callot, Laurent; Haldrup, Niels; Kallestrup-Lamb, Malene

2015-01-01

The Lee and Carter (1992) model assumes that the deterministic and stochastic time series dynamics load with identical weights when describing the development of age-specific mortality rates. Effectively this means that the main characteristics of the model simplify to a random walk model with age...... mortality data. We find empirical evidence that this feature of the Lee–Carter model overly restricts the system dynamics and we suggest to separate the deterministic and stochastic time series components at the benefit of improved fit and forecasting performance. In fact, we find that the classical Lee......–Carter model will otherwise overestimate the reduction of mortality for the younger age groups and will underestimate the reduction of mortality for the older age groups. In practice, our recommendation means that the Lee–Carter model instead of a one-factor model should be formulated as a two- (or several...

INCA Modelling of the Lee System: strategies for the reduction of nitrogen loads

Science.gov (United States)

Flynn, N. J.; Paddison, T.; Whitehead, P. G.

The Integrated Nitrogen Catchment model (INCA) was applied successfully to simulate nitrogen concentrations in the River Lee, a northern tributary of the River Thames for 1995-1999. Leaching from urban and agricultural areas was found to control nitrogen dynamics in reaches unaffected by effluent discharges and abstractions; the occurrence of minimal flows resulted in an upward trend in nitrate concentration. Sewage treatment works (STW) discharging into the River Lee raised nitrate concentrations substantially, a problem which was compounded by abstractions in the Lower Lee. The average concentration of nitrate (NO3) for the simulation period 1995-96 was 7.87 mg N l-1. Ammonium (NH4) concentrations were simulated less successfully. However, concentrations of ammonium rarely rose to levels which would be of environmental concern. Scenarios were run through INCA to assess strategies for the reduction of nitrate concentrations in the catchment. The conversion of arable land to ungrazed vegetation or to woodland would reduce nitrate concentrations substantially, whilst inclusion of riparian buffer strips would be unsuccessful in reducing nitrate loading. A 50% reduction in nitrate loading from Luton STW would result in a fall of up to 5 mg N l-1 in the reach directly affected (concentrations fell from maxima of 13 to 8 mg N l-1 , nearly a 40 % reduction), whilst a 20% reduction in abstractions would reduce maximum peaks in concentration in the lower Lee by up to 4 mg l-1 (from 17 to 13 mg N l-1, nearly a 25 % reduction),.

A critique of the Lees-Marshment market-oriented party model

DEFF Research Database (Denmark)

Ormrod, Robert P.

2006-01-01

This article presents conceptual and empirical criticisms of the Lees-Marshment market-oriented party model. Conceptual criticisms are the short-term approach, the narrow focus on voters, the nature of the relationship to competitors, a tendency towards centralisation and the lack of a distinction...

Interactions between yeast lees and wine polyphenols during simulation of wine aging: I. Analysis of remnant polyphenolic compounds in the resulting wines.

Science.gov (United States)

Mazauric, Jean-Paul; Salmon, Jean-Michel

2005-07-13

Wine aging on yeast lees is a traditional enological practice used during the manufacture of wines. This technique has increased in popularity in recent years for the aging of red wines. Although wine polyphenols interact with yeast lees to a limited extent, such interactions have a large effect on the reactivity toward oxygen of wine polyphenolic compounds and yeast lees. Various domains of the yeast cell wall are protected by wine polyphenols from the action of extracellular hydrolytic enzymatic activities. Polysaccharides released during autolysis are thought to exert a significant effect on the sensory qualities of wine. We studied the chemical composition of polyphenolic compounds remaining in solution or adsorbed on yeast lees after various contact times during the simulation of wine aging. The analysis of the remnant polyphenols in the wine indicated that wine polyphenols adsorption on yeast lees follows biphasic kinetics. An initial and rapid fixation is followed by a slow, constant, and saturating fixation that reaches its maximum after about 1 week. Only very few monomeric phenolic compounds remained adsorbed on yeast lees, and no preferential adsorption of low or high polymeric size tannins occurred. The remnant condensed tannins in the wine contained fewer epigallocatechin units than the initial tannins, indicating that polar condensed tannins were preferentially adsorbed on yeast lees. Conversely, the efficiency of anthocyanin adsorption on yeast lees was unrelated to its polarity.

Outlining the influence of non-conventional yeasts in wine ageing over lees.

Science.gov (United States)

Belda, Ignacio; Navascués, Eva; Marquina, Domingo; Santos, Antonio; Calderón, Fernando; Benito, Santiago

2016-07-01

During the last decade, the use of innovative yeast cultures of both Saccharomyces cerevisiae and non-Saccharomyces yeasts as alternative tools to manage the winemaking process have turned the oenology industry. Although the contribution of different yeast species to wine quality during fermentation is increasingly understood, information about their role in wine ageing over lees is really scarce. This work aims to analyse the incidence of three non-Saccharomyces yeast species of oenological interest (Torulaspora delbrueckii, Lachancea thermotolerans and Metschnikowia pulcherrima) and of a commercial mannoprotein-overproducer S. cerevisiae strain compared with a conventional industrial yeast strain during wine ageing over lees. To evaluate their incidence in mouthfeel properties of wine after 4 months of ageing, the mannoprotein content of wines was evaluated, together with other wine analytic parameters, such as colour and aroma, biogenic amines and amino acids profile. Some differences among the studied parameters were observed during the study, especially regarding the mannoprotein concentration of wines. Our results suggest that the use of T. delbrueckii lees in wine ageing is a useful tool for the improvement of overall wine quality by notably increasing mannoproteins, reaching values higher than obtained using a S. cerevisiae overproducer strain. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Selective Migration among Southern Blacks: A Reinterpretation of Lee (1951).

Science.gov (United States)

Wolff, JosePh L.

1979-01-01

Explanations of differences in IQs of Northern and Southern Blacks focus on selective migration (hereditarians) or environmental causes such as education, discrimination and cultural deprivation. In this paper the environmentalist position is questioned and certain neglected features of Lee's data are construed as providing strong evidence for…

CXCL14 Blockade of CXCL12/CXCR4 Signaling in Prostate Cancer Bone Metastasis

Science.gov (United States)

2017-10-01

10.1158/0008-5472.CAN-04-3785. 55. Jung Y, Kim JK, Shiozawa Y, Wang J, Mishra A, Joseph J, Berry JE, McGee S, Lee E, Sun H, Wang J, Jin T, Zhang H...and unfortunate complication of advanced prostate cancer resulting in significant pain and fractures . The most devastating consequence, however, is...treatments. These data suggest a mechanism of increased migration and invasion may be associated with expression of EMT genes. Regulation of Kinase

A Highly Responsive Silicon Nanowire/Amplifier MOSFET Hybrid Biosensor

Science.gov (United States)

2015-07-21

Hybrid Biosensor Jieun Lee1,2, Jaeman Jang1, Bongsik Choi1, Jinsu Yoon1, Jee-Yeon Kim3, Yang-Kyu Choi3, Dong Myong Kim1, Dae Hwan Kim1 & Sung-Jin Choi1...This study demonstrates a hybrid biosensor comprised of a silicon nanowire (SiNW) integrated with an amplifier MOSFET to improve the current response...of field-effect-transistor (FET)-based biosensors . The hybrid biosensor is fabricated using conventional CMOS technology, which has the potential

Modulation of Estrogen-Depurinating DNA Adducts by Sulforaphane for Breast Cancer

Science.gov (United States)

2014-12-01

system in cancers: stress response and anabolic metabolism. Front. Oncol., 2, 200. doi: 10.3389/ fonc.2012.00200. 20. Agyeman,S.A. et  al. (2012...to science education and young scientists. We look forward to working with you. Sincerely, Chuck  37 From: "Gary A. Lorigan...Drosophila," by Ki Moon Seong, Mira Yu, Kyu-Sun Lee, Young Woo Jin and Kyung J. Min, and for taking the time and effort to review this manuscript. Best

Cleófilas and La Llorona: Latin Heroines Against Patriarchal Marginalisation in ‘El arroyo de la Llorona’, a Short Story by Sandra Cisneros

OpenAIRE

Luis fernando Gómez R

2012-01-01

This paper discusses the short story ‘El arroyo de la Llorona’ by female Mexican-American writer Sandra Cisneros. In it the main character, Cleófilas, is subject to social, emotional and economic dependence on her husband, according to the cultural constructs on female identity that are still relevant in Latin-American patriarchal societies. Due to her circumstances of complete marginalisation and domestic violence, Cleófilas chooses to avoid reality, and this avoidance not only costs her men...

Lee Miller à travers la Roumanie, l’appareil photo à la main (1946

Directory of Open Access Journals (Sweden)

Adrian-Silvan Ionescu

2012-01-01

Full Text Available A former model and fashion photographer turned war photographer, Lee Miller visited Romania twice, in 1938 and 1946 respectively. After her second visit she published her impressions and pictures, under the title of Roumania, in Vogue magazine. Besides the published material there are her manuscripts from The Lee Miller Achives at Farley Farm House, East Sussex, England, on which this paper is based. She crossed the border coming from Hungary in early February 1946. Heading for Sibiu her car, a Chevrolet Sedan, slipping on the ice-covered road, stopped on a snowbank far off in the ditch. While looking for help in the nearby village she and her companions left the car unguarded to discover it plundered of everything, wheels included.On a Sunday afternoon she had the privilege of being received by King Mihai I and Queen Mother Elena with whom she talked exstensively. She also took magnificent pictures with the Royal Family in the imposing Peleş Castle. At Sinaia, „the summer capital of Roumania” she had also the opportunity to portray Dinu Brătianu and Iuliu Maniu, the two elderly statesmen. Maniu was surrounded by friends and party members, among whom was young Corneliu Coposu, his private secretary.Moving to Bucharest, she met old friends such as Harri Brauner and his wife, Lena Constante, with whom she wandered through the country eight years ago. Lena and Elena Pătrășcanu, wife of Lucrețiu Pătrășcanu, Minister of Justice, have started a successful marionette theatre where Lee took nice pictures. Other were taken on the streets, with peasants, street vendors and their customers. Harri took her to a bistro where they met Maria Lătărețu, the celebrating folk singer whom Brauner recorded many times. They enjoyed her songs. Suffering from fibrositis, Lee Miller undertook a peculiar treatment in a gypsy village where the inhabitants were dancing bears trainers. She was massaged by a bear weighing about 300 pounds while Brauner took

A State-Space Estimation of the Lee-Carter Mortality Model and Implications for Annuity Pricing

OpenAIRE

Man Chung Fung; Gareth W. Peters; Pavel V. Shevchenko

2015-01-01

In this article we investigate a state-space representation of the Lee-Carter model which is a benchmark stochastic mortality model for forecasting age-specific death rates. Existing relevant literature focuses mainly on mortality forecasting or pricing of longevity derivatives, while the full implications and methods of using the state-space representation of the Lee-Carter model in pricing retirement income products is yet to be examined. The main contribution of this article is twofold. Fi...

APF-The Lick Observatory Automated Planet Finder

Science.gov (United States)

2014-04-01

WILLIAM DEICH,1 BRIAN DUPRAW,1 WAYNE EARTHMAN,1 HARLAND EPPS,1 SANDRA FABER,1 DEBRA FISCHER ,3 ELINOR GATES,1 DAVID HILYARD,1 BRAD HOLDEN,1 KEN JOHNSTON,4...SANDY KEISER,2 DICK KANTO,1 MYRA KATSUKI,1 LEE LAITERMAN,1 KYLE LANCLOS,1 GREG LAUGHLIN,1 JEFF LEWIS,1 CHRIS LOCKWOOD,1,5 PAUL LYNAM,1 GEOFFREY MARCY,6...with S. Vogt as principal investigator, G. Marcy and D. Fischer as coinvestgators, and M. Radovan as project manager and principal engineer. A large

Diglossie et biculturalisme littéraires :le cas de A Free Life, de Ha Jin

OpenAIRE

Perrin, Isabelle

2013-01-01

Le roman La Liberté de vivre, de Ha Jin, place son lecteur face à un type d’« écriture-traduction », puisqu’il suit le parcours d’un Chinois contraint par son exil aux États-Unis après les événements de Tian’anmen d’adopter la langue et la culture américaines. La représentation mimétique du réel joue sur le concept d’étrangeté, que le texte fait fonctionner en miroir : étrangeté des référents langagiers et culturels américains pour le héros chinois, étrangeté des référents langagiers et cultu...

A 90-day study of sub-chronic oral toxicity of 20 nm positively charged zinc oxide nanoparticles in Sprague Dawley rats

Directory of Open Access Journals (Sweden)

Park HS

2014-12-01

Full Text Available Hark-Soo Park,1 Seon-Ju Kim,1 Taek-Jin Lee,1 Geon-Yong Kim,1 EunHo Meang,1 Jeong-Sup Hong,1 Su-Hyon Kim,1 Sang-Bum Koh,1 Seung-Guk Hong,1 Yle-Shik Sun,1 Jin Seok Kang,2 Yu-Ri Kim,3 Meyoung-Kon Kim,3 Jayoung Jeong,4 Jong-Kwon Lee,4 Woo-Chan Son,5 Jae-Hak Park61General Toxicology Team, Korea Testing and Research Institute, Seoul, 2Department of Biomedical Laboratory Science, Namseoul University, Cheonan, 3Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, 4National Institute of Food and Drug Safety Evaluation, Seoul, 5Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 6Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, KoreaPurpose: The study reported here was conducted to determine the systemic oral toxicity and to find the no-observed-adverse-effect level of 20 nm positively charged zinc oxide (ZnOSM,20(+ nanoparticles in Sprague Dawley rats for 90 days.Methods: For the 90-day toxicity study, the high dose was set as 500 mg per kg of body weight (mg/kg and the middle and low dose were set to 250 mg/kg and 125 mg/kg, respectively. The rats were held for a 14-day recovery period after the last administration, to observe for the persistence or reduction of any toxic effects. A distributional study was also carried out for the systemic distribution of ZnOSM,20(+ NPs.Results: No rats died during the test period. There were no significant clinical changes due to the test article during the experimental period in functional assessment, body weight, food and water consumption, ophthalmological testing, urine analysis, necropsy findings, or organ weights, but salivation was observed immediately after administration in both sexes. The total red blood cell count was increased, and hematocrit, albumin, mean cell volume, mean cell hemoglobin, and mean cell hemoglobin concentration were decreased significantly compared with

The analysis of Sandra Cisneros' House on Mango Steet based on social criticism of Gloria Anzaldúa's Borderlands: La Frontera

Directory of Open Access Journals (Sweden)

Špela Grum

2015-12-01

Full Text Available The article deals with the main female characters that appear in Sandra Cisneros' collection of vignettes, House on Mango Street (1991. It sheds light on their lives and motives for their actions, through social criticism of Gloria Anzaldúa and the main points she establishes in her semi-autobiographical collection of essays Borderlands: La Frontera (1999. The topics Anzaldúa addresses give an insight into the Chicano identity, and the struggle of Chicano women in particular. Through her vantage point, I discuss gender roles, the immigrants' search for identity and their quest for a more dignified life, by trying to reconcile the antagonizing forces of the different parts of their identity.

Brassia campestris L. ssp. chinensis L.var. utilis Tsen et Lee

African Journals Online (AJOL)

omodibo

2012-12-31

Dec 31, 2012 ... On the basis of morphological and cultural features, the pathogen ... Alternaria isolate from Purple-Caitai showed 99% identity with other ITS sequences of .... Cho KH, Park SH, Kim KT, Kim S, Kim JS, Park BS, Woo JG, Lee HJ.

Numerical Simulation of a Lee Wave Case over Three-Dimensional Mountainous Terrain under Strong Wind Condition

Directory of Open Access Journals (Sweden)

Lei Li

2013-01-01

Full Text Available This study of a lee wave event over three-dimensional (3D mountainous terrain in Lantau Island, Hong Kong, using a simulation combining mesoscale model and computational fluid dynamics (CFD model has shown that (1 3D steep mountainous terrain can trigger small scale lee waves under strong wind condition, and the horizontal extent of the wave structure is in a dimension of few kilometers and corresponds to the dimension of the horizontal cross-section of the mountain; (2 the life cycle of the lee wave is short, and the wave structures will continuously form roughly in the same location, then gradually move downstream, and dissipate over time; (3 the lee wave triggered by the mountainous terrain in this case can be categorized into “nonsymmetric vortex shedding” or “turbulent wake,” as defined before based on water tank experiments; (4 the magnitude of the wave is related to strength of wind shear. This study also shows that a simulation combining mesoscale model and CFD can capture complex wave structure in the boundary layer over realistic 3D steep terrain, and have a potential value for operational jobs on air traffic warning, wind energy utilization, and atmospheric environmental assessment.

Armed Forces Institute of Regenerative Medicine Annual Report 2011

Science.gov (United States)

2012-01-01

using the virus . They have generated high titer viruses for both the decorin and CAR- decorin and produced high yields of decorins devoid of the...involve goats, sheep, dogs, cats , and primates with nerve gaps ranging from 3–90 mm. However, large animal studies are very expensive and take 2–4 years...Leader(s): George Christ, PhD (WFIRM) Project Team Members: James Yoo, MD, PhD, Sang Jin Lee, PhD, Benjamin T. Corona , PhD, and Masood A

N-Terminal Tau Fragments as Biomarkers for Alzheimer’s Disease and Neurotrauma

Science.gov (United States)

2014-10-01

from the Tau Front: Cantoblanco 2013 J Alzheimers Dis Parkinsonism 4, e133 3. Saman S, Lee N, Inoyo I, Jin J, Li Z, Doyle T, McKee AC, Hall GF...diseases, as mitochondrial markers are prominently associated with Parkinsons Disease (hsa05012) and Huntington’s Disease (hsa05016) as well as AD...connectivity in Figure 2b, the 1” boxes (shaded) were placed so as to maximize icon inclusion (black dots) for each 1.9” diagram shown. The

Markkinointisuunnitelma digitaaliseen markkinointiin Case Baan Lee Beach Resort & Sauna

OpenAIRE

Lähteenmäki, Essi

2017-01-01

Tämän opinnäytetyön tavoitteena on kehittää Baan Lee Beach Resort & Saunan digitaalista markkinointia markkinointisuunnitelman avulla. Yritys on aloittamassa liiketoimintaansa erittäin kilpailulla alalla, jossa digitaalinen markkinointi on tärkeä osa kilpailussa menestymistä ja se on otettava huomioon yrityksen markkinointistrategian tärkeänä osana. Markkinointisuunnitelmalla pyritään takaamaan markkinointistrategian mukainen toiminta. Markkinointisuunnitelmassa kuvataan yrityksen nykyti...

Servicing the first web server - Tim Berners-Lee's NeXT

CERN Multimedia

unknown, Association aBCM

2009-01-01

In August 2009 a team from the Association aBCM in Lausanne came to CERN to give the world's first web server a health check under the watchful eye of web pioneer Robert Cailliau. They took an image of the hard drive at this time, copies of which were given to Robert Cailliau and Tim Berners-Lee.

In Pompeii and Volterra the Earth Really Trembles: De-Territorialisation, European Art-Cinema, and the Fate of Neorealism in Roberto Rossellini's Journey to ltaly and Luchino Visconti's Sandra

Directory of Open Access Journals (Sweden)

Stefano Ciammaroni

2007-06-01

Full Text Available Este trabalho se utiliza de dois estudos de caso - Viagem to Italy (1953, de Roberto Rossellini e Sandra (1965, de Luchino Visconti para discutir questões políticas, historiográficas e estéticas [que interferem] no relacionamento entre o neo-realismo como cinema da nação italiana e o "cinema de arte europeu" como uma instituição desnacionalizada.

A relation between deformed superspace and Lee-Wick higher-derivative theories

Science.gov (United States)

Dias, M.; Ferrari, A. F.; Palechor, C. A.; Senise, C. R., Jr.

2015-07-01

We propose a non-anticommutative superspace that relates to the Lee-Wick type of higher-derivative theories, which are known for their interesting properties and have led to proposals of phenomenologically viable higher-derivative extensions of the Standard Model. The deformation of superspace we consider does not preserve supersymmetry or associativity in general, but, we show that a non-anticommutative version of the Wess-Zumino model can be properly defined. In fact, the definition of chiral and antichiral superfields turns out to be simpler in our case than in the well known N=1/2 supersymmetric case. We show that when the theory is truncated at the first nontrivial order in the deformation parameter, supersymmetry is restored, and we end up with a well-known Lee-Wick type of higher-derivative extension of the Wess-Zumino model. Thus, we show how non-anticommutativity could provide an alternative mechanism for generating these higher-derivative theories.

Forecasting the mortality rates using Lee-Carter model and Heligman-Pollard model

Science.gov (United States)

Ibrahim, R. I.; Ngataman, N.; Abrisam, W. N. A. Wan Mohd

2017-09-01

Improvement in life expectancies has driven further declines in mortality. The sustained reduction in mortality rates and its systematic underestimation has been attracting the significant interest of researchers in recent years because of its potential impact on population size and structure, social security systems, and (from an actuarial perspective) the life insurance and pensions industry worldwide. Among all forecasting methods, the Lee-Carter model has been widely accepted by the actuarial community and Heligman-Pollard model has been widely used by researchers in modelling and forecasting future mortality. Therefore, this paper only focuses on Lee-Carter model and Heligman-Pollard model. The main objective of this paper is to investigate how accurately these two models will perform using Malaysian data. Since these models involves nonlinear equations that are explicitly difficult to solve, the Matrix Laboratory Version 8.0 (MATLAB 8.0) software will be used to estimate the parameters of the models. Autoregressive Integrated Moving Average (ARIMA) procedure is applied to acquire the forecasted parameters for both models as the forecasted mortality rates are obtained by using all the values of forecasted parameters. To investigate the accuracy of the estimation, the forecasted results will be compared against actual data of mortality rates. The results indicate that both models provide better results for male population. However, for the elderly female population, Heligman-Pollard model seems to underestimate to the mortality rates while Lee-Carter model seems to overestimate to the mortality rates.

Comparisons of predictive values of sarcopenia with different muscle mass indices in Korean rural older adults: a longitudinal analysis of the Aging Study of PyeongChang Rural Area

Directory of Open Access Journals (Sweden)

Jang IY

2018-01-01

Full Text Available Il-Young Jang,1,2,* Hee-Won Jung,3,4,* Chang Ki Lee,5 Sang Soo Yu,2 Young Soo Lee,1 Eunju Lee1 1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 2PyeongChang Health Center & County Hospital, Gangwon-Do, 3Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST, Daejeon, 4Geriatric Center, Seoul National University Bundang Hospital, Gyeonggi-Do, 5Goldman Urology Clinic, Seoul, Republic of Korea *These authors contributed equally to this work Purpose: It is important to define lean muscle mass when diagnosing sarcopenia, but there is still controversy on the clinical implication of sarcopenia derived by height, weight, and body mass index (BMI adjusted muscle mass indices. We aimed to evaluate the longitudinal clinical relevance of 3 sarcopenia definitions in the Korean population. Patients and methods: We conducted comprehensive geriatric assessments for 1,379 community-dwelling older participants in the Aging Study of PyeongChang Rural Area (ASPRA cohort and followed them up prospectively for death, institutionalization, and disability every 3 months. Sarcopenia was defined using the Asian Working Group consensus algorithm, combining grip strength, gait speed, and muscle mass.Results: Among 1,343 participants (mean age: 76 years, 741 women analyzed, there were 29 deaths and 89 institutionalizations during 22.0 ± 8.3 months follow-up (mean ± SD. All three muscle indices correlated to age and sex. All sarcopenia criteria with muscle mass indices of height, weight, and body mass index (BMI adjustment significantly predicted death or institutionalization. However, when adjusted for age and sex, only the sarcopenia criteria with muscle mass index of height adjustment were significantly associated with major adverse health outcomes.Conclusion: Adjusting age and gender, the sarcopenia definition from the quintile-based muscle index of height

Optimization Evaluation: Lee Chemical Superfund Site, City Of Liberty, Clay County, Missouri

Science.gov (United States)

The Lee Chemical Superfund Site (site) is located along Missouri Highway 210 in Liberty, Missouri, approximately 15 miles east of Kansas City, Missouri. Currently, the site is a vacant lot of approximately2.5 acres in a flat alluvial plain.

Latent class analysis on internet and smartphone addiction in college students

OpenAIRE

Mok, Jung-Yeon; Choi, Sam-Wook; Kim, Dai-Jin; Choi, Jung-Seok; Lee, Jaewon; Ahn, Heejune; Choi, Eun-Jeung; Song, Won-Young

2014-01-01

Jung-Yeon Mok,1 Sam-Wook Choi,1,2 Dai-Jin Kim,3 Jung-Seok Choi,4 Jaewon Lee,2 Heejune Ahn,5 Eun-Jeung Choi,6 Won-Young Song7 1Eulji Addiction Institute, Eulji University, Seoul, South Korea; 2Department of Psychiatry, Gangnam Eulji Hospital, Eulji University, Seoul, South Korea; 3Department of Psychiatry, Seoul St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, South Korea; 4Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, South Korea; 5Depar...

Komisjon plaanib ökotoodete eelistamist liidu hangetel / Merike Lees

Index Scriptorium Estoniae

Lees, Merike, 1976-

2004-01-01

Euroopa Komisjon kavatseb luua reeglid, mis annavad hangetel eelise lisaks keskkonnajuhtimisstandardeid rakendanud ettevõtetele ka ühenduse ökomärgist omavatele toodetele. Ettevõtete juhtide kommentaarid ökomärgise kasutamise kohta. Lisad: Ökotoode peab vastama ligi paarikümnele kriteeriumile; Ökomärgise litsentsi eeltöö tehakse Eestis. Vt. samas: Ökomärgise litsentsi väljastav pädev asutus tuleb Eestisse. Kommenteerivad Merike Lees ja Anu-Maaja Pallok

Tentative identification of polar and mid-polar compounds in extracts from wine lees by liquid chromatography-tandem mass spectrometry in high-resolution mode.

Science.gov (United States)

Delgado de la Torre, M P; Priego-Capote, F; Luque de Castro, M D

2015-06-01

Sustainable agriculture has a pending goal in the revalorization of agrofood residues. Wine lees are an abundant residue in the oenological industry. This residue, so far, has been used to obtain tartaric acid or pigments but not for being qualitatively characterized as a source of polar and mid-polar compounds such as flavonoids, phenols and essential amino acids. Lees extracts from 11 Spanish wineries have been analyzed by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) in high resolution mode. The high-resolution power of LC-MS/MS has led to the tentative identification of the most representative compounds present in wine lees, comprising primary amino acids, anthocyans, flavanols, flavonols, flavones and non-flavonoid phenolic compounds, among others. Attending to the profile and content of polar and mid-polar compounds in wine lees, this study underlines the potential of wine lees as an exploitable source to isolate interesting compounds. Copyright © 2015 John Wiley & Sons, Ltd.

HISTORY EDUCATION - SOME THOUGHTS FROM THE UK: interviews Peter J. Lee

Directory of Open Access Journals (Sweden)

Cristiani Bereta da Silva

2014-05-01

Peter Lee was, until he very recently retired, a senior lecturer in the History Education Unit at the Institute of Education at the University of London. Having taught History in primary and secondary schools, Professor Lee has coordinated several research projects related to History Teaching and Learning, including CHATA (Concepts of History and Teaching Approaches a project well-known in Brazil. Several of his publications investigate the ideas that children and teenagers have over History in several books, chapters, and articles – many of these with Rosalyn Ashby as co-author.  Some of his articles have been translated to Portuguese, circulating among researchers concerned with understanding how children learn History. The questions in this interview have been elaborated so that Peter Lee’s reflections may collaborate with the development of History Teaching and History Education research in Brazil. All contact has been made via e-mail, a rather useful tool that has shortened the distance between Florianópolis and London for a few long moments between July and October 2012.

' "Life is Movement": Vernon Lee and Sculpture'

DEFF Research Database (Denmark)

Østermark-Johansen, Lene

2018-01-01

How do living, breathing human bodies respond to the inert bodies of sculpture? This article examines some of the art-theoretical and psychological writings of Violet Paget (‘Vernon Lee’) and Clementina Anstruther-Thomson of the 1880s and 1890s in an attempt to map the evolution of their formalist...... art criticism. Engaging with the eighteenth-century ghosts of Johann Joachim Winckelmann and Gotthold Ephraim Lessing, Lee and Anstruther-Thomson created their very own exploration of art forms evolving in space and in time. Questioning how our reading of literature affects our reading of sculpture...... from Lee’s early essays in Belcaro: Being Essays on Sundry Aesthetical Questions (1881) to the late collaborative volume Art and Man (1924)....

Looking for Asian butch-dykes: exploring filmic representations of East Asian butch-dykes in Donna Lee's Enter the Mullet.

Science.gov (United States)

Lin, Hui-Ling

2009-01-01

Asian butch-dykes have been overlooked in analyses of Chinese cinema, studies that often concentrate on "feminized" transgender roles. This article examines cinematic representations of Asian butch-dykes through film analysis of Enter the Mullet (2004), a five-minute short, and in-depth interviews with the filmmaker, Donna Lee, a Chinese-Canadian in Vancouver. Lee's film is inspired by Enter the Dragon (1973), starring Bruce Lee, the most recognized icon of Asian masculinity. Combining with the mullet hairstyle, which is often associated with White working-class, the filmmaker introduces viewers to the hybrid masculinity of Asian butch-dykes. The article argues that Asian female masculinity can be a strategic means of destabilizing the hegemony of White-male-middle-class masculinity.

Vertical structure and microphysical characteristics of precipitation on the high terrain and lee side of the Olympic Mountains

Science.gov (United States)

Zagrodnik, J. P.; McMurdie, L. A.; Houze, R.

2017-12-01

As mid-latitude cyclones pass over coastal mountain ranges, the processes producing their clouds and precipitation are modified when they encounter complex terrain, leading to a maximum in precipitation fallout on the windward slopes and a minimum on the lee side. The precipitation that does reach the high terrain and lee side of a mountain range can be theoretically determined by a complex interaction between the dynamics of air lifting over the terrain, the thermodynamics of moist air, and the microphysical time required to grow particles large enough to fall out. To date, there have been few observational studies that have focused on the nonlinear microphysical processes contributing to the variability of precipitation that is received on the lee side slopes of a mountain range such as the Olympic Mountains. The 2015-16 Olympic Mountains Experiment (OLYMPEX) collected unprecedented observations on the high terrain and lee side of the Olympic Mountains including frequent soundings on Vancouver Island, dual-polarization Doppler radar, multi-frequency airborne radar, and ground-based particle size and crystal habit observations at the higher elevation Hurricane Ridge site. We utilize these observations to examine the evolution of the vertical structure and microphysical precipitation characteristics over the high terrain and leeside within the context of large-scale dynamic and thermodynamic conditions that evolve during the passage of cold season mid-latitude cyclones. The primary goal is to determine the degree to which the observed variability in lee side precipitation amount and microphysical properties are controlled by variations in temperature, flow speed and direction, shear, and stability associated with characteristic synoptic storm sectors and frontal passages.

On the Seventh Day, He Rested: Lee Kuan Yew and the Creation of Singapore

National Research Council Canada - National Science Library

Neary, Patrick C

1997-01-01

...-oriented domestic policies in pursuit of national goals. Lee's paternal authoritarianism proved to be highly successful, but this success sowed the seeds of discontent now producing weeds in his island paradise.

Phenolic characterization of aging wine lees: Correlation with antioxidant activities.

Science.gov (United States)

Romero-Díez, R; Rodríguez-Rojo, S; Cocero, M J; Duarte, C M M; Matias, A A; Bronze, M R

2018-09-01

Aging wine lees are water-wastes produced during the wine aging inside wood barrels that can be considered as alternative sources of bioactive compounds. Phenolic characterization and antioxidant activity (AA) measurements of wines lees solid-liquid extracts have been undertaken on a dry extract (DE) basis. Solvents with different polarities (water, methanol, ethanol, two hydroalcoholic mixtures and acetone) were used. Total phenolic (TPC) and total flavonoid contents (TFC) were determined. The mixture of 75:25(v/v) EtOH:H 2 O showed the highest values with 254 mg GAE /g DE and 146 mg CATE /g DE respectively. HORAC, HOSC and FRAP were used to determine the AA of the extracts being also highest for the mixture of 75:25(v/v) EtOH:H 2 O (4690 µmol CAE /g DE , 4527 µmol TE /g DE and 2197 µmol TE /g DE , respectively). For ORAC method, methanol extract showed the best value with 2771 µmol TE /g DE . Correlations between TPC, TFC, phenolic compounds and AA were determined. Most relevant compounds contributing to AA were identified using data from mass spectrometry, being mainly anthocyanins. Copyright © 2018 Elsevier Ltd. All rights reserved.

Pharmacokinetic and bioequivalence study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828) formulation and coadministered telmisartan and S-amlodipine in healthy subjects

OpenAIRE

Kang,Woo Youl; Seong,Sook Jin; Ohk,Boram; Gwon,Mi-Ri; Kim,Bo Kyung; La,Sookie; Kim,Hyun-Ju; Cho,Seungil; Yoon,Young-Ran; Yang,Dong Heon; Lee,Hae Won

2018-01-01

Woo Youl Kang,1,2,* Sook Jin Seong,1,* Boram Ohk,1,2 Mi-Ri Gwon,1,3 Bo Kyung Kim,1,2 Sookie La,4 Hyun-Ju Kim,3 Seungil Cho,1 Young-Ran Yoon,1,2 Dong Heon Yang,5 Hae Won Lee1 1Clinical Trial Center, Kyungpook National University Hospital, Daegu, Republic of Korea; 2Department of Biomedical Science, BK21 Plus KNU Bio-Medical Convergence Program for Creative Talent, Kyungpook National University Graduate School, Daegu, Republic of Korea; 3Department of Molecular Medicine, Cell and Matrix Resear...

Tissue distribution and excretion kinetics of orally administered silica nanoparticles in rats

Directory of Open Access Journals (Sweden)

Lee JA

2014-12-01

Full Text Available Jeong-A Lee,1 Mi-Kyung Kim,1 Hee-Jeong Paek,1 Yu-Ri Kim,2 Meyoung-Kon Kim,2 Jong-Kwon Lee,3 Jayoung Jeong,3 Soo-Jin Choi1 1Department of Food Science and Technology, Seoul Women’s University, Seoul, Republic of Korea; 2Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, Republic of Korea; 3Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Chungchungbuk–do, Republic of Korea Purpose: The effects of particle size on the tissue distribution and excretion kinetics of silica nanoparticles and their biological fates were investigated following a single oral administration to male and female rats. Methods: Silica nanoparticles of two different sizes (20 nm and 100 nm were orally administered to male and female rats, respectively. Tissue distribution kinetics, excretion profiles, and fates in tissues were analyzed using elemental analysis and transmission electron microscopy. Results: The differently sized silica nanoparticles mainly distributed to kidneys and liver for 3 days post-administration and, to some extent, to lungs and spleen for 2 days post-administration, regardless of particle size or sex. Transmission electron microscopy and energy dispersive spectroscopy studies in tissues demonstrated almost intact particles in liver, but partially decomposed particles with an irregular morphology were found in kidneys, especially in rats that had been administered 20 nm nanoparticles. Size-dependent excretion kinetics were apparent and the smaller 20 nm particles were found to be more rapidly eliminated than the larger 100 nm particles. Elimination profiles showed 7%–8% of silica nanoparticles were excreted via urine, but most nanoparticles were excreted via feces, regardless of particle size or sex. Conclusion: The kidneys, liver, lungs, and spleen were found to be the target organs of orally-administered silica nanoparticles in rats, and this organ

Lee-side flow structures of very low aspect ratio cruciform wing–body configurations

CSIR Research Space (South Africa)

Tuling, S

2013-12-01

Full Text Available A numerical and experimental investigation was performed to study the dominant flow structures in the lee side of a cruciform wing–body configuration at supersonic speeds in the + orientation. The wings or strakes are of very low aspect ratio...

Näitleja Tommy Lee Jonesi meditatsioon režissööritoolis / Andris Feldmanis

Index Scriptorium Estoniae

Feldmanis, Andris, 1982-

2007-01-01

Vestern "Melquiades Estrada kolm matust" ("The Three Burials of Melquiades Estrada") : stsenarist Guillermo Arriaga : režissöör ja osatäitja Tommy Lee Jones : operaator Chris Menges : Ameerika Ühendriigid, 2005

Comparison of a new digital KM screen test with conventional Hess and Lees screen tests in the mapping of ocular deviations.

Science.gov (United States)

Thorisdottir, Rannveig Linda; Sundgren, Johanna; Sheikh, Rafi; Blohmé, Jonas; Hammar, Björn; Kjellström, Sten; Malmsjö, Malin

2018-05-28

To evaluate the digital KM screen computerized ocular motility test and to compare it with conventional nondigital techniques using the Hess and Lees screens. Patients with known ocular deviations and a visual acuity of at least 20/100 underwent testing using the digital KM screen and the Hess and Lees screen tests. The examination duration, the subjectively perceived difficulty, and the patient's method of choice were compared for the three tests. The accuracy of test results was compared using Bland-Altman plots between testing methods. A total of 19 patients were included. Examination with the digital KM screen test was less time-consuming than tests with the Hess and Lees screens (P digital KM screen). Patients found the test with the digital KM screen easier to perform than the Lees screen test (P = 0.009) but of similar difficulty to the Hess screen test (P = 0.203). The majority of the patients (83%) preferred the digital KM screen test to both of the other screen methods (P = 0.008). Bland-Altman plots showed that the results obtained with all three tests were similar. The digital KM screen is accurate and time saving and provides similar results to Lees and Hess screen testing. It also has the advantage of a digital data analysis and registration. Copyright © 2018 American Association for Pediatric Ophthalmology and Strabismus. Published by Elsevier Inc. All rights reserved.

The Pitzer-Lee-Kesler-Teja (PLKT) Strategy and Its Implementation by Meta-Computing Software

Czech Academy of Sciences Publication Activity Database

Smith, W. R.; Lísal, Martin; Missen, R. W.

2001-01-01

Roč. 35, č. 1 (2001), s. 68-73 ISSN 0009-2479 Institutional research plan: CEZ:AV0Z4072921 Keywords : The Pitzer -Lee-Kesler-Teja (PLKT) strategy * implementation Subject RIV: CF - Physical ; Theoretical Chemistry

Ocean PHILLS Data Collection and Processing: May 2000 Deployment, Lee Stocking Island, Bahamas

National Research Council Canada - National Science Library

Leathers, Robert

2002-01-01

.... It was deployed in a region near Lee Stocking Island (LSI), Bahamas in May 2000. This document describes the LSI 2000 PHILLS data set and the manner in which it was processed to obtain remote-sensing reflectance images for use by the scientific community...

Comparison of Benedict-Webb-Rubin, Starling and Lee-Kesler equations of state for use in P-V-T calculations

International Nuclear Information System (INIS)

McFee, D.G.; Mueller, K.H.; Lielmezs, J.

1982-01-01

By means of the available experimental gas compressibility data, the predictive accuracy of the Benedict-Webb-Rubin, Starling and Lee-Kesler equations was tested over wide temperature and pressure ranges for the following commonly used industrial gases: CH 4 , C 2 H 6 , C 3 H 8 , CO 2 , Ar, He, H 2 and N 2 . The root mean square (RMS) percent errors calculated over the T-P range investigated for all compounds, showed a degree of superiority and ease of use of the Lee-Kesler equation over the Benedict-Webb-Rubin and Starling equations. In order to treat quantal fluids H 2 and He, the Benedict-Webb-Rubin equation was modified by making constant B 0 temperature dependent, while the Starling and Lee-Kesler equations were rewritten through inclusion of quantum effect corrected pseudo-critical state parameters. (orig.)

77 FR 18852 - Lee Metcalf National Wildlife Refuge, Stevensville, MT; Draft Comprehensive Conservation Plan and...

Science.gov (United States)

2012-03-28

... business hours at the Lee Metcalf National Wildlife Refuge headquarters located at 4567 Wildfowl Lane... habitats and has created and modified wetlands. Riverfront forest includes early succession tree species...

Tuning of Lee Path Loss Model based on recent RF measurements in 400 MHZ conducted in Riyadh City, Saudi Arabia

International Nuclear Information System (INIS)

Alotaibi, Faihan D.; Ali, Adel A.

2008-01-01

In mobile radio systems, path loss models are necessary for proper planning, interference estimations, frequently assignments and cell parameters which are basic for network planning process as well as Location Based Services (LBS) techniques that are not based on GPS system. Empirical models are the most adjustable models that can be suited to different types of environments. In this paper, the Lee path loss model has been tuned using Least Square (LS) algorithm to fit measured data for TETRA system operating 400 MHz in Riyadh urban and suburbs. Consequently, Lee model's parameter (L0, y) are obtained for the targeted areas. The performance of the tuned Lee model is then compared to the three most widely used empirical path loss models: Hat, ITU-R and Cost 231 Walfisch-Ikegami non line-of-sight (CWI-NLOS) path loss models. The performance criterion selected for the comparison of various empirical path loss models are the Root Mean Square Error (RMSE) and goodness of fit (R2). The RMSE and R2between the actual and predicted data are calculated for various path loss models. It turned that the tuned Lee model outperforms the other empirical models. (author)

Lee as Critical Thinker: The Example of the Gettysburg Campaign

Science.gov (United States)

2012-05-04

importance were “ Hannibal , Frederick the Great, and especially Napoleon, all of whom were models for Lee as he led the Army of Northern Virginia in battle...Cannae, Leuthen, and Austerlitz. The Battle of Cannae culminated in a double envelopment by Hannibal against the Romans and “is important…because...it shows how Hannibal was able to completely surround a much larger force Roman force (40,000 versus 70,000, as compared with Lee’s 74,000 facing

Dynamic Changes Analysis and Hotspots Detection of Land Use in the Central Core Functional Area of Jing-Jin-Ji from 2000 to 2015 Based on Remote Sensing Data

Directory of Open Access Journals (Sweden)

Yafei Li

2017-01-01

Full Text Available The article uses GIS spatial analysis and grid technologies to study the dynamic changes, hotspot regions, and driving forces in land use of the central core functional area of Jing-Jin-Ji. The research results are as follows: from 2000 to 2015, the main types of land use in the central core functional area of Jing-Jin-Ji are cultivated land, woodland, and built-up land. In the period of 2005–2010, the transfer between built-up land and cultivated land was frequent. The dynamic degree of single land use in unused land was highest. It also finds out that the dynamic degree of the integrated land use from 2005 to 2010 was higher. The center of gravity transfer of the dynamic degree of integrated land use was concentrated in research area. As for the hotspots, their number and scope are increasing, and the positions located in the edge of original main urban area and developed transportation network. The main characteristics of land use dynamic change in the study area are the rapid decrease of cultivated land area and rapid growth of built-up land. The spatial agglomeration of economic factors caused by human activities has an important influence on the spatial and temporal dynamic changes of land use.

Grey relational analysis for evaluating the effects of different rates of wine lees-derived biochar application on a plant-soil system with multi-metal contamination.

Science.gov (United States)

Xu, Min; Zhu, Qihong; Wu, Jun; He, Yan; Yang, Gang; Zhang, Xiaohong; Li, Li; Yu, Xiaoyu; Peng, Hong; Wang, Lilin

2018-03-01

In this study, grey relational analysis (GRA) was used to investigate the effects of different application rates of wine lees-derived biochar on a plant-soil system with multi-metal contamination. A pot experiment was conducted to determine rice growth in multi-metal-contaminated soil amended with samples of wine lees-derived biochar, and 47 indicators (including soil properties, microbial activity, and plant physiology) were selected as evaluation indexes to assess the plant-soil system. The results indicated that higher wine lees-derived biochar application rates (2% W/W) were favorable for soil fertility, the bioconcentration factor (BF), and the mobility factor (MF, %) (with the exception of Cr, Zn, and Hg), but an application of 1% produced the highest plant growth, enzymatic activities, and bacterial diversity. The richness of the bacterial communities was reduced in the soil amended with the wine lees-derived biochar. According to the GRA assessment, the 1% application rate of wine lees-derived biochar was more suitable for restoring the holistic plant-soil system than were the application rates of 0, 0.5, and 2% (W/W). Furthermore, this study shows that GRA is a useful method for evaluating plant-soil systems.

Presence of sarcopenia in asthma–COPD overlap syndrome may be a risk factor for decreased bone-mineral density, unlike asthma: Korean National Health and Nutrition Examination Survey (KNHANES IV and V (2008–2011

Directory of Open Access Journals (Sweden)

Lee DW

2017-08-01

Full Text Available Dong-Won Lee,1 Hyun-Jung Jin,2 Kyeong-Cheol Shin,2 Jin-Hong Chung,2 Hyoung-Woo Lee,3 Kwan-Ho Lee2 1Division of Pulmonology, Department of Internal Medicine, Andong Sungso Hospital, Andong, 2Division of Pulmonology and Allergy, 3Division of Endocrinology, Department of Internal Medicine, Yeungnam University Hospital, Daegu, South Korea Background: Sarcopenia and decreased bone-mineral density (BMD are common in elderly people, and are major comorbidities of obstructive airway disease (OAD. However, the relationship between sarcopenia and BMD in each OAD phenotype, especially asthma–COPD overlap syndrome (ACOS, is not yet clear. We aimed to evaluate differences in BMD according to the presence of sarcopenia in each OAD phenotype. Materials and methods: Among the research subjects in KNHANES IV and V (2008–2011, 5,562 were ≥50 years old and underwent qualified spirometry and dual-energy X-ray absorptiometry. A total of 947 subjects were included in the study: 89 had asthma, 748 COPD, and 110 ACOS. Results: In the COPD and ACOS phenotypes, T-scores were lower in the sarcopenia group than the nonsarcopenia group. Prevalence rates of osteopenia and osteoporosis were higher in the sarcopenia group than the nonsarcopenia group. (P<0.001 and P=0.017, respectively. The sarcopenia group had higher risks of developing osteopenia, osteoporosis, and low BMD than the nonsarcopenia group in the ACOS phenotype (OR 6.620, 95% CI 1.129–38.828 [P=0.036], OR 9.611, 95% CI 1.133–81.544 [P=0.038], and OR 6.935, 95% CI 1.194–40.272 [P=0.031], respectively. However, in the asthma phenotype, the sarcopenia group showed no increased risk compared with the nonsarcopenia group. Conclusion: In the ACOS phenotype, individuals with sarcopenia had a higher prevalence rate and higher risks of osteopenia and osteoporosis than those without sarcopenia among all OAD phenotypes. Keywords: asthma, chronic obstructive pulmonary disease, asthma–COPD overlap syndrome

Nobelist TD LEE Scientist Cooperation Network and Scientist Innovation Ability Model

OpenAIRE

Fang, Jin-Qing; Liu, Qiang

2013-01-01

Nobelist TD Lee scientist cooperation network (TDLSCN) and their innovation ability are studied. It is found that the TDLSCN not only has the common topological properties both of scale-free and small-world for a general scientist cooperation networks, but also appears the creation multiple-peak phenomenon for number of published paper with year evolution, which become Nobelist TD Lee’s significant mark distinguished from other scientists. This new phenomenon has not been revealed in the scie...

Berners-Lee and the IPEN reality

International Nuclear Information System (INIS)

Sacramento, Jose Miguel Noronha; Rogero, Jose Roberto

2010-01-01

This article discusses a study held with researchers from IPEN and organizations that operate or could act as IPEN partners or clients on research projects and consumption of its products and services. The survey had its origin in the perception of the difficulties in alignment of IPEN with the demands of society, taking as a point of attention processes used in the disclosure and dissemination of scientific knowledge to the public other than the academic communities or specialists in the areas of IPEN usually operates. Were mapped communication flows between the researchers of IPEN and between companies and the IPEN so as to identify the necessary conditions to improve communication between different universes such as academic and business. The comparison of the conditions currently found in the IPEN with the 1991 initial proposal of Tim Berners-Lee when creating the World Wide Web to CERN and with web portals of organizations similar to IPEN provided valuable grants for the planning of next steps of IPEN organization in terms of its relationship with potential partners and, ultimately, the society. (author)

Transcriptional control of the isoeugenol monooxygenase of Pseudomonas nitroreducens Jin1 in Escherichia coli.

Science.gov (United States)

Ryu, Ji-Young; Seo, Jiyoung; Ahn, Joong-Hoon; Sadowsky, Michael J; Hur, Hor-Gil

2012-01-01

Vanillin is one of the most valuable compounds in the flavoring and fragrance industries, and many attempts to produce natural vanillin have been made in recent years. Isoeugenol monooxygenase (Iem) converts the phenylpropanoid compound isoeugenol to vanillin. In Pseudomonas nitroreducens Jin1, the positive regulatory protein IemR is divergently expressed from Iem, and the promoter region is located between the genes. In this study, we investigated the transcriptional regulation of iem in Escherichia coli. We focused on inducers and regulatory protein IemR. Transcription of iem was found to be dependent on the amounts of isoeugenol and IemR. Isoeugenol was found to be the best inducer of iem, followed by trans-anethole, which induced iem to 58% of the transcription level observed for isoeugenol. Overproduction of IemR in E. coli significantly increased the transcription of iem, up to 96-fold, even in the absence of isoeugenol, as compared to basally expressed IemR. Results of this study indicate that the transcription of iem iss dependent on the type of inducers and on IemR. They should contribute to the development of bioengineering strategies for increased production of vanillin through high-level expression of the isoeugenol monooxygenase gene in microorganisms.

Effects of amoxicillin/clavulanic acid on the pharmacokinetics of valproic acid

Directory of Open Access Journals (Sweden)

Lee SY

2015-08-01

Full Text Available Soo-Yun Lee,1 Wooseong Huh,2 Jin Ah Jung,3 Hye Min Yoo,2 Jae-Wook Ko,1,2 Jung-Ryul Kim2,4 1Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, 2Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, Seoul, 3Department of Clinical Pharmacology, Inje University, Busan Paik Hospital, Busan, 4Department of Clinical Research and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea Abstract: Valproic acid (VPA is mainly metabolized via glucuronide, which is hydrolyzed by β-glucuronidase and undergoes enterohepatic circulation. Amoxicillin/clavulanic acid (AMC administration leads to decreased levels of β-glucuronidase-producing bacteria, suggesting that these antibiotics could interrupt enterohepatic circulation and thereby alter the pharmacokinetics of VPA. This study aimed to evaluate the effects of AMC on the pharmacokinetics of VPA. This was an open-label, two-treatment, one-sequence study in 16 healthy volunteers. Two treatments were evaluated; treatment VPA, in which a single dose of VPA 500 mg was administered, and treatment AMC + VPA, in which multiple doses of AMC 500/125 mg were administered three times daily for 7 days and then a single dose of VPA was administered. Blood samples were collected up to 48 hours. Pharmacokinetic parameters were calculated using noncompartmental methods. Fifteen subjects completed the study. Systemic exposures and peak concentrations of VPA were slightly lower with treatment AMC + VPA than with treatment VPA (AUClast, 851.0 h·mg/L vs 889.6 h·mg/L; Cmax, 52.1 mg/L vs 53.0 mg/L. There were no significant between-treatment effects on pharmacokinetics (95% confidence interval [CI] of AUClast and Cmax (95.7 [85.9–106.5] and 98.3 [91.6–105.6], respectively. Multiple doses of AMC had no significant effects on the pharmacokinetics of VPA; thus, no dose adjustment is necessary. Keywords: drug–drug interaction, pharmacokinetics

The Friedberg-Lee symmetry and minimal seesaw model

International Nuclear Information System (INIS)

He Xiaogang; Liao Wei

2009-01-01

The Friedberg-Lee (FL) symmetry is generated by a transformation of a fermionic field q to q+ξz. This symmetry puts very restrictive constraints on allowed terms in a Lagrangian. Applying this symmetry to N fermionic fields, we find that the number of independent fields is reduced to N-1 if the fields have gauge interaction or the transformation is a local one. Using this property, we find that a seesaw model originally with three generations of left- and right-handed neutrinos, with the left-handed neutrinos unaffected but the right-handed neutrinos transformed under the local FL translation, is reduced to an effective theory of minimal seesaw which has only two right-handed neutrinos. The symmetry predicts that one of the light neutrino masses must be zero.

THE YUAN-TSEH LEE ARRAY FOR MICROWAVE BACKGROUND ANISOTROPY

International Nuclear Information System (INIS)

Ho, Paul T. P.; Altamirano, Pablo; Chang, C.-H.; Chang, S.-H.; Chang, S.-W.; Chen, C.-C.; Chen, K.-J.; Chen, M.-T.; Han, C.-C.; Ho, West M.; Huang, Y.-D.; Hwang, Y.-J.; Ibanez-Romano, Fabiola; Jiang Homin; Koch, Patrick M.; Kubo, Derek Y.; Li, C.-T.; Lim, Jeremy; Lin, K.-Y.; Liu, G.-C.

2009-01-01

The Yuan-Tseh Lee Array for microwave background anisotropy is the first interferometer dedicated to study the cosmic microwave background radiation at 3 mm wavelength. The choice of 3 mm is to minimize the contributions from foreground synchrotron radiation and Galactic dust emission. The initial configuration of seven 0.6 m telescopes mounted on a 6 m hexapod platform was dedicated in 2006 October on Mauna Loa, Hawaii. Scientific operations began with the detection of a number of clusters of galaxies via the thermal Sunyaev-Zel'dovich effect. We compare our data with Subaru weak-lensing data to study the structure of dark matter. We also compare our data with X-ray data to derive the Hubble constant.

’n Murgtere saak: ’n Gendermatige lees van Boom van my lewe en Ad hominem

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Louisemarié Combrink

2012-11-01

Full Text Available Hierdie artikel bied ontleed twee kunstenaarsboeke deur manlike kunstenaars wat aan die praktykgebaseerderde navorsingsprojek Oor die einders van die bladsy deelgeneem het. Die gekose kunstenaars spreek spesifiek die gedagte van manlike weerloosheid en verwonding aan en maak in die proses van ’n aantal sogenaamde manlike maar veral ook vroulike genderbetekenaars gebruik. Schutte se Boom van my lewe en Strydom en Burger se Ad hominem word ondersoek. Daar word aangevoer dat die gebruik van veral konvensioneel vroulike mediums tesame met temas wat sowel ’n manlike as vroulike karakter het, meewerk om die ervaring van manlike weerloosheid en verwonding op so ’n wyse te kommunikeer dat ’n ongewone manlike subjekposisie daargestel word. Hierdie subjekposisie bied ’n meer genuanseerde beskouing van manlikheid as wat konvensionele (heteronormatiewe en selfs ook sogenaamde ‘nuwe’ of alternatiewe manlike subjekposisies (soos transgender, homoseksueel en dies meer diskoerse bied.

Acceleration of ageing on lees in red wines by application of ultrasounds

OpenAIRE

Fresno, Juan Manuel del; Morata Barrado, Antonio Dionisio; Loira, Iris; Escott, Carlos; Cuerda, Rafael; Calderon Fernandez, Fernando; Suarez Lepe, Jose Antonio

2017-01-01

A transfer of parietal polysaccharides and mannoproteins is produced during aging on lees [1]. This transfer of compounds to wine is carried out after cell death. It comes to breakdown of polysaccharides from cell wall (yeast autolysis). This technique increases the density in wines [2] and gives more body and structure. Interactions between yeast polysaccharides and wine tannins will result in decrease of tannic perception (decrease of astringency). Increase of varietal characteristics is pr...

The Brain Dead Patient Is Still Sentient: A Further Reply to Patrick Lee and Germain Grisez.

Science.gov (United States)

Austriaco, Nicanor Pier Giorgio

2016-06-01

Patrick Lee and Germain Grisez have argued that the total brain dead patient is still dead because the integrated entity that remains is not even an animal, not only because he is not sentient but also, and more importantly, because he has lost the radical capacity for sentience. In this essay, written from within and as a contribution to the Catholic philosophical tradition, I respond to Lee and Grisez's argument by proposing that the brain dead patient is still sentient because an animal with an intact but severed spinal cord can still perceive and respond to external stimuli. The brain dead patient is an unconscious sentient organism. © The Author 2016. Published by Oxford University Press, on behalf of the Journal of Medicine and Philosophy Inc. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Nonsingular cosmology with a scale-invariant spectrum of cosmological perturbations from Lee-Wick theory

International Nuclear Information System (INIS)

Cai Yifu; Qiu Taotao; Brandenberger, Robert; Zhang Xinmin

2009-01-01

We study the cosmology of a Lee-Wick type scalar field theory. First, we consider homogeneous and isotropic background solutions and find that they are nonsingular, leading to cosmological bounces. Next, we analyze the spectrum of cosmological perturbations which result from this model. Unless either the potential of the Lee-Wick theory or the initial conditions are finely tuned, it is impossible to obtain background solutions which have a sufficiently long period of inflation after the bounce. More interestingly, however, we find that in the generic noninflationary bouncing cosmology, perturbations created from quantum vacuum fluctuations in the contracting phase have the correct form to lead to a scale-invariant spectrum of metric inhomogeneities in the expanding phase. Since the background is nonsingular, the evolution of the fluctuations is defined unambiguously through the bounce. We also analyze the evolution of fluctuations which emerge from thermal initial conditions in the contracting phase. The spectrum of gravitational waves stemming from quantum vacuum fluctuations in the contracting phase is also scale-invariant, and the tensor to scalar ratio is not suppressed.

Fighting with Reality: Considering Mark Johnson's Pragmatic Realism through Bruce Lee's Jeet Kune Do Method

Science.gov (United States)

Miller, Alexander David

2015-01-01

This dissertation considers the supportive and complementary relation between Mark Johnson's embodied realism and Bruce Lee's Jeet Kune Do as a philosophical practice. In exploring this relationship, the emphasis on one's embodiment condition and its relationship with metaphor and self-expression are the primary focus. First, this work involves…

77 FR 14032 - John H. Chafee Coastal Barrier Resources System; Lee County, FL, and Newport County, RI...

Science.gov (United States)

2012-03-08

... conduct a comprehensive review of the history of the CBRS unit in question. The Service has a large... by Lee County, and 1 restaurant. The Service's assessment of 2011 aerial imagery estimates that the...

Functional renormalization group approach to the Yang-Lee edge singularity

Energy Technology Data Exchange (ETDEWEB)

An, X. [Department of Physics, University of Illinois at Chicago,845 W. Taylor St., Chicago, IL 60607 (United States); Mesterházy, D. [Albert Einstein Center for Fundamental Physics, University of Bern,Sidlerstrasse 5, 3012 Bern (Switzerland); Stephanov, M.A. [Department of Physics, University of Illinois at Chicago,845 W. Taylor St., Chicago, IL 60607 (United States)

2016-07-08

We determine the scaling properties of the Yang-Lee edge singularity as described by a one-component scalar field theory with imaginary cubic coupling, using the nonperturbative functional renormalization group in 3≤d≤6 Euclidean dimensions. We find very good agreement with high-temperature series data in d=3 dimensions and compare our results to recent estimates of critical exponents obtained with the four-loop ϵ=6−d expansion and the conformal bootstrap. The relevance of operator insertions at the corresponding fixed point of the RG β functions is discussed and we estimate the error associated with O(∂{sup 4}) truncations of the scale-dependent effective action.

Reescribir la historia desde la frontera: reparación de la memoria en Engel des Vergessens de Maja Haderlap y Caramelo o puro cuento de Sandra Cisneros

Directory of Open Access Journals (Sweden)

Ana Gimenez Calpe

2016-04-01

Full Text Available A parir del análisis comparativo de dos novelas recientes, Engel des Vergessens, de Maja Haderlap, y Caramelo o Puro cuento, de Sandra Cisneros, el artículo examina los mecanismos empleados en los textos para  reescribir la historia nacional, recuperando y reorganizando para ello los recuerdos familiares de las narradoras protagonistas. Este proceso se produce en un contexto transnacional, en el que los límites entre países vecinos quedan cada vez más difusos. En este sentido, el artículo examina la reescritura de la memoria nacional desde la perspectiva de unos actantes determinados, esto es, de unos personajes en continuo tránsito entre fronteras.  

Analysis of the membrane fouling on cross-flow ultrafiltration and microfiltration of soy sauce lees; Shoyuhiireden no kurosuforo roka ni okeru fauringu no kaiseki

Energy Technology Data Exchange (ETDEWEB)

Furukakwa, T. [Kikkoman Corporation, Chiba (Japan); Kobayashi, H.; Kokubo, K.; Watanabe, A. [Niigata University, Niigata (Japan). Graduate School of Science and Technology

2000-05-10

Although since the 1980's Japanese soy sauce manufactures have developed cross-flow membrane filtration systems to recover soy sauce from its lees, the mechanisms by which the membrane fouls during filtration have not been theoretically discussed. Calculated flux declines using a theoretical equation developed for cross-flow cake filtration were compared against experimental results involving the filtration of soy sauce lees using polysulfone ultrafiltration and micro filtration membranes. Membrane fouling due to the deposition and intrusion of soy sauce lees was evaluated from the hydraulic resistances of the membrane and the cake layer. Calculated flux declines with time agree with the experimental results. Specific resistance of the cake layer which is an adjustable parameter of the equation, decreases with increasing cross-flow velocity. Hydraulic resistance exhibited by the membranes is independent of feed flow velocity. However, the resistance of the cake layers decreases with increasing cross-flow velocity. This corresponds to the steady-state flux increase. In conclusion, the main cause of fouling in the filtration of soy sauce lees is cake layer formation. By using the cake filtration model for cross-flow, the flux decline with time during the filtration is capable of being predicted. (author)

Space-time PM2.5 mapping in the severe haze region of Jing-Jin-Ji (China) using a synthetic approach.

Science.gov (United States)

He, Junyu; Christakos, George

2018-05-07

Long- and short-term exposure to PM 2.5 is of great concern in China due to its adverse population health effects. Characteristic of the severity of the situation in China is that in the Jing-Jin-Ji region considered in this work a total of 2725 excess deaths have been attributed to short-term PM 2.5 exposure during the period January 10-31, 2013. Technically, the processing of large space-time PM 2.5 datasets and the mapping of the space-time distribution of PM 2.5 concentrations often constitute high-cost projects. To address this situation, we propose a synthetic modeling framework based on the integration of (a) the Bayesian maximum entropy method that assimilates auxiliary information from land-use regression and artificial neural network (ANN) model outputs based on PM 2.5 monitoring, satellite remote sensing data, land use and geographical records, with (b) a space-time projection technique that transforms the PM 2.5 concentration values from the original spatiotemporal domain onto a spatial domain that moves along the direction of the PM 2.5 velocity spread. An interesting methodological feature of the synthetic approach is that its components (methods or models) are complementary, i.e., one component can compensate for the occasional limitations of another component. Insight is gained in terms of a PM 2.5 case study covering the severe haze Jing-Jin-Ji region during October 1-31, 2015. The proposed synthetic approach explicitly accounted for physical space-time dependencies of the PM 2.5 distribution. Moreover, the assimilation of auxiliary information and the dimensionality reduction achieved by the synthetic approach produced rather impressive results: It generated PM 2.5 concentration maps with low estimation uncertainty (even at counties and villages far away from the monitoring stations, whereas during the haze periods the uncertainty reduction was over 50% compared to standard PM 2.5 mapping techniques); and it also proved to be computationally very

Gu Jin Tan Gai with the Perspective of Carnival Poetics%狂欢诗学视域下的《古今谭概》

Institute of Scientific and Technical Information of China (English)

刘云春; 赵豫科

2014-01-01

《古今谭概》是晚明著名文学家冯梦龙编纂的一部笑话集。他在博览历代正史、稗官野史的基础上，选取众多可笑有趣的逸闻趣事，以戏谑的口吻略加评点，遂成此集。《古今谭概》内容多为真人真事，上自历代君主，下至市井百姓，各色人等，种种笑话，应有尽有。本文运用文艺理论家巴赫金的狂欢诗学理论，从时空狂欢、语言狂欢、体裁狂欢、狂欢的内核几个层面对其进行解读，论述了作品产生的时代背景和狂欢化艺术特色，旨在发掘文本内涵，拓宽文本研究视野，发现其更深层次的文学价值。%Gu Jin Tan Gai is a collection of jokes compiled by Feng Menglong. He selects many stories from the official history and the romance and comments in a bantering tone. A majority of the content is true which in-cludes emperors and common people. This paper uses the Russian literary theorist Bakhtin's Carnival Poetics theory to discuss four aspects:space - time carnival,language carnival,style carnival,carnival essence. The paper dis-cusses the background and carnival artistic characteristics of Gu Jin Tan Gai to find the deeper value of literature.

Distribution of non-LEE-encoded type 3 secretion system dependent effectors in enteropathogenic Escherichia coli

Directory of Open Access Journals (Sweden)

Fábia A. Salvador

2014-09-01

Full Text Available Enteropathogenic Escherichia coli (EPEC are important human gastroenteritis agents. The prevalence of six non-LEE genes encoding type 3 translocated effectors was investigated. The nleC, cif and nleB genes were more prevalent in typical than in atypical EPEC, although a higher diversity of genes combinations was observed in atypical EPEC.

Generation of hyperchaos from the Chen-Lee system via sinusoidal perturbation

International Nuclear Information System (INIS)

Tam, L.M.; Chen, J.H.; Chen, H.K.; Wai Meng Si Tou

2008-01-01

A system with more than one positive Lyapunov exponent can be classified as a hyperchaotic system. In this study, a sinusoidal perturbation was designed for generating hyperchaos from the Chen-Lee chaotic system. The hyperchaos was identified by the existence of two positive Lyapunov exponents and bifurcation diagrams. The system is hyperchaotic in several different regions of the parameters c, ε, and ω. It was found that this method not only can enhance or suppress chaotic behavior, but also induces chaos in non-chaotic parameter ranges. In addition, two interesting dynamical behaviors, Hopf bifurcation and intermittency, were also found in this study

Generation of hyperchaos from the Chen-Lee system via sinusoidal perturbation

Energy Technology Data Exchange (ETDEWEB)

Tam, L.M. [Department of Electromechanical Engineering, Faculty of Science and Technology, University of Macau, Av. Padre Thomas Pereira S.J., Taipa, Macau (China)], E-mail: fstlmt@umac.mo; Chen, J.H. [Department of Mechanical Engineering, Chung Hua University, Hsinchu, Taiwan (China); Chen, H.K. [Department of Mechanical Engineering, Hsiuping Institute of Technology, Taichung, Taiwan (China); Wai Meng Si Tou [Department of Electromechanical Engineering, Faculty of Science and Technology, University of Macau, Av. Padre Thomas Pereira S.J., Taipa, Macau (China)

2008-11-15

A system with more than one positive Lyapunov exponent can be classified as a hyperchaotic system. In this study, a sinusoidal perturbation was designed for generating hyperchaos from the Chen-Lee chaotic system. The hyperchaos was identified by the existence of two positive Lyapunov exponents and bifurcation diagrams. The system is hyperchaotic in several different regions of the parameters c, {epsilon}, and {omega}. It was found that this method not only can enhance or suppress chaotic behavior, but also induces chaos in non-chaotic parameter ranges. In addition, two interesting dynamical behaviors, Hopf bifurcation and intermittency, were also found in this study.

Lee-Yang zeroes and logarithmic corrections in the Φ44 theory

International Nuclear Information System (INIS)

Kenna, R.; Lang, C.B.

1993-01-01

The leading mean-field critical behaviour of φ 4 4 -theory is modified by multiplicative logarithmic corrections. We analyse these corrections both analytically and numerically. In particular we present a finite-size scaling theory for the Lee-Yang zeroes and temperature zeroes, both of which exhibit logarithmic corrections. On lattices from size 8 4 to 24 4 , Monte-Carlo cluster methods and multi-histogram techniques are used to determine the partition function zeroes closest to the critical point. Finite-size scaling behaviour is verified and the logarithmic corrections are found to be in good agreement with our analytical predictions. (orig.)

Study of provenance character on ancient celadon of Jin Dynasty produced in Yaozhou Kiln of Lidipo and Shangdian using nuclear technology

International Nuclear Information System (INIS)

Wang, Y.Q.; Feng, S.L.; Feng, X.Q.; Lei, Y.; Cheng, L.; Xu, Q.; Zhou, Z.X.; Xue, D.X.

2005-01-01

Yaozhou ware is a typical product of celadon porcelain in northern China. It was very famous for the various color glazes, multiple utensils and unique grain pattern. Yaozhou kiln series were made of Tongchuan, Lidipo, Shangdian, Chenlu kiln site and etc in Shanxi Province of china. It is one of seven kiln series in China. Celadon samples of 63 pieces of sherds were collected, which excavated in stratum of Jin Dynasty (1127-1234A.D.) from Yaozhou kiln of Lidipo and Shangdian sites. The main and trace elements of theses specimens were analyzed by NAA and EDXRF respectively. The contents of 10 main and 18 trace elements were determined precisely. The experimental data are performed with factor and discrimination analysis of statistic method. The result indicates that the trace elements can reveal the provenance character of porcelain better than main compositions.

Electricity generation using white and red wine lees in air cathode microbial fuel cells

Science.gov (United States)

Pepe Sciarria, Tommy; Merlino, Giuseppe; Scaglia, Barbara; D'Epifanio, Alessandra; Mecheri, Barbara; Borin, Sara; Licoccia, Silvia; Adani, Fabrizio

2015-01-01

Microbial fuel cell (MFC) is a useful biotechnology to produce electrical energy from different organic substrates. This work reports for the first time results of the application of single chamber MFCs to generate electrical energy from diluted white wine (WWL) and red wine (RWL) lees. Power obtained was of 8.2 W m-3 (262 mW m-2; 500 Ω) and of 3.1 W m-3 (111 mW m-2; 500Ω) using white and red wine lees, respectively. Biological processes lead to a reduction of chemical oxygen (TCOD) and biological oxygen demand (BOD5) of 27% and 83% for RWL and of 90% and 95% for WWL, respectively. These results depended on the degradability of organic compounds contained, as suggest by BOD5/TCOD of WWL (0.93) vs BOD5/TCOD of RWL (0.33), and to the high presence of polyphenols in RWL that inhibited the process. Coulombic efficiency (CE) of 15 ± 0%, for WWL, was in line with those reported in the literature for other substrates, i.e. CE of 14.9 ± 11.3%. Different substrates led to different microbial consortia, particularly at the anode. Bacterial species responsible for the generation of electricity, were physically connected to the electrode, where the direct electron transfer took place.

Comments, with reply, on 'Parallel resonant converter with LLC-type commutation' by C. Q. Lee et al.

Science.gov (United States)

Hamill, David C.

1991-05-01

In a recent paper by Lee et al. (1989), the authors analyzed a DC-DC converter that they termed the LLC-type PRC (parallel resonant converter). Its resonant network contains three active components-two inductances and a parallel capacitance -and as a consequence the the converter might be expected to have third-order dynamics. But Lee et al. employed a matrix transformation to show that the behavior of the circuit may be represented as a state-plane trajectory, as for a second-order circuit. The purpose of this contribution is to show that the converter has a zero-frequency eigenvalue, associated with undesirable circulating DC. The second-order dynamics exhibited by the third-order converter are explained by an application of Thevenin's theorem. Some aerospace applications of the LLC-type parallel resonant converter (PRC) are discussed. In their reply, the authors show that the circulating direct current does not exist in the practical converter circuit.

Analyses and optimization of Lee propagation model for LoRa 868 MHz network deployments in urban areas

Directory of Open Access Journals (Sweden)

Dobrilović Dalibor

2017-01-01

Full Text Available In the recent period, fast ICT expansion and rapid appearance of new technologies raised the importance of fast and accurate planning and deployment of emerging communication technologies, especially wireless ones. In this paper is analyzed possible usage of Lee propagation model for planning, design and management of networks based on LoRa 868MHz technology. LoRa is wireless technology which can be deployed in various Internet of Things and Smart City scenarios in urban areas. The analyses are based on comparison of field measurements with model calculations. Besides the analyses of Lee propagation model usability, the possible optimization of the model is discussed as well. The research results can be used for accurate design, planning and for preparation of high-performance wireless resource management of various Internet of Things and Smart City applications in urban areas based on LoRa or similar wireless technology. The equipment used for measurements is based on open-source hardware.

78 FR 77508 - Duke Energy Carolinas, LLC; William States Lee III Nuclear Station, Units 1 and 2; Combined...

Science.gov (United States)

2013-12-23

... NUCLEAR REGULATORY COMMISSION [Docket Nos. 52-018 and 52-019; NRC-2008-0170] Duke Energy Carolinas, LLC; William States Lee III Nuclear Station, Units 1 and 2; Combined Licenses Application Review AGENCY: Nuclear Regulatory Commission. ACTION: Final environmental impact statement; availability...

Lee Silverman Voice Treatment for People with Parkinson's: Audit of Outcomes in a Routine Clinic

Science.gov (United States)

Wight, Sheila; Miller, Nick

2015-01-01

Background: Speaking louder/more intensely represents a longstanding technique employed to manage voice and intelligibility changes in people with Parkinson's. This technique has been formalized into a treatment approach and marketed as the Lee Silverman Voice Treatment (LSVT®) programme. Evidence for its efficacy has been published. Studies…

Oxidative stress by layered double hydroxide nanoparticles via an SFK-JNK and p38-NF-κB signaling pathway mediates induction of interleukin-6 and interleukin-8 in human lung epithelial cells

Directory of Open Access Journals (Sweden)

Choi SJ

2015-04-01

Full Text Available Soo-Jin Choi, Hee-Jeong Paek, Jin YuDepartment of Food Science and Technology, Seoul Women’s University, Seoul, Republic of KoreaAbstract: Anionic nanoclays are layered double hydroxide nanoparticles (LDH-NPs that have been shown to exhibit toxicity by inducing reactive oxidative species and a proinflammatory mediator in human lung epithelial A549 cells. However, the molecular mechanism responsible for this LDH-NP-induced toxicity and the relationship between oxidative stress and inflammatory events remains unclear. In this study, we focused on intracellular signaling pathways and transcription factors induced in response to oxidative stress caused by exposure to LDH-NPs in A549 cells. Mitogen-activated protein kinase (MAPK cascades, such as extracellular signal-regulated kinase, c-Jun-N-terminal kinase (JNK, and p38, were investigated as potential signaling mechanisms responsible for regulation of oxidative stress and cytokine release. Src family kinases (SFKs, which are known to mediate activation of MAPK, together with redox-sensitive transcription factors, including nuclear factor kappa B and nuclear factor-erythroid 2-related factor-2, were also investigated as downstream events of MAPK signaling. The results obtained suggest that LDH-NP exposure causes oxidative stress, leading to expression of antioxidant enzymes, such as catalase, glucose reductase, superoxide dismutase, and heme oxygenase-1, via a SFK-JNK and p38-nuclear factor kappa B signaling pathway. Further, activation of this signaling was also found to regulate release of inflammatory cytokines, including interleukin-6 and interleukin-8, demonstrating the inflammatory potential of LDH-NP.Keywords: layered double hydroxide, mitogen-activated protein kinases, Src family kinases, nuclear factor kappa B, oxidative stress, inflammatory cytokine

Quantum-statistical mechanics of an atom-dimer mixture: Lee-Yang cluster expansion approach

International Nuclear Information System (INIS)

Ohkuma, Takahiro; Ueda, Masahito

2006-01-01

We use the Lee-Yang cluster expansion method to study quantum-statistical properties of a mixture of interconvertible atoms and dimers, where the dimers form in a two-body bound state of the atoms. We point out an infinite series of cluster diagrams whose summation leads to the Bose-Einstein condensation of the dimers below a critical temperature. Our theory captures some important features of a cold atom-dimer mixture such as interconversion of atoms and dimers and properties of the mixture at the unitarity limit

Adaptation of Sing Lee's model to the Filippov type plasma focus geometry

International Nuclear Information System (INIS)

Siahpoush, V; Tafreshi, M A; Sobhanian, S; Khorram, S

2005-01-01

A new model for plasma behaviour in Filippov type plasma focus (PF) systems has been described and used. This model is based on the so-called slug model and Sing Lee's model for Mather type PF devices. Using the model, the discharge current and its derivative as a function of time, and the pinch time and the maximum discharge current as a function of pressure, have been predicted. At the end, the predicted data are compared with the experimental data obtained through a Filippov type PF facility with a nominal maximum energy of 90 kJ

The cost-effectiveness analysis of JinQi Jiangtang tablets for the treatment on prediabetes: a randomized, double-blind, placebo-controlled, multicenter design.

Science.gov (United States)

Sun, Xiao; Guo, Liping; Shang, Hongcai; Ren, Ming; Wang, Yue; Huo, Da; Lei, Xiang; Wang, Hui; Zhai, Jingbo

2015-11-03

reduced the incidence of diabetes mellitus and enhanced reversion rate. compared with the control group (p 0.05); finally the compliance of participants between the two groups had no significant difference. The cost-effectiveness analysis outcomes:in the intervention period of 12 months,on the aspect of reversion rate, the treatment group had better economic advantage by using cost-effectiveness ratio and the incremental cost-effectiveness ratio;on the aspect of the incidence of diabetes, the control group had better economic advantage by using cost-effectiveness ratio and the incremental cost-effectiveness ratio; in the follow-up period of 24 months, on the aspect of reversion rate, the treatment group had better economic advantage by using cost-effectiveness ratio and the incremental cost-effectiveness ratio, on the aspect of the incidence of diabetes, the control group had better economic advantage by using cost-effectivenes ratio and the incremental cost-effectiveness ratio.At the same time, these outcomes remained the same by sensitivity analysis. Assuming that prices and resident incomes rose 5%, the sensitiveness analysis shows that the two group affected by the paremeters changed little. The importance and effectiveness of lifestyle education and JinQi Jiangtang tablets was proven. In both the intervention period and follow-up, JinQi Jiangtang tablets combined with lifestyle education had a greater cost advantage effect than the lifestyle education alone on the reversion rate; the lifestyle education had a greater cost advantage effect than the JinQi Jiangtang tablets combined with lifestyle education on the incidence of diabetes. Chinese Clinical Trials ChiCTR-TRC-09000401 ) , registered on 25 May 2009.

Cleófilas and La Llorona: Latin Heroines Against Patriarchal Marginalisation in ‘El arroyo de la Llorona’, a Short Story by Sandra Cisneros

Directory of Open Access Journals (Sweden)

Luis fernando Gómez R

2012-08-01

Full Text Available This paper discusses the short story ‘El arroyo de la Llorona’ by female Mexican-American writer Sandra Cisneros. In it the main character, Cleófilas, is subject to social, emotional and economic dependence on her husband, according to the cultural constructs on female identity that are still relevant in Latin-American patriarchal societies. Due to her circumstances of complete marginalisation and domestic violence, Cleófilas chooses to avoid reality, and this avoidance not only costs her mental well-being,but also annuls her will to make changes to her suffocating life. Oppressed by a patriarchal system,Cleófilas develops an unusual interest in the Llorona legend and, through the remembrance of this myth, these two female figures become symbols of resistance and liberation. In the story, the Llorona ceases to be the denigrated woman tradition has always made her out to be, and becomes the image of a contemporary heroine capable of challenging radical patriarchal norms.

Visioni vittoriane: il paesaggio fiorentino nelle opere di Janet Ross e Vernon Lee

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Gabriele Corsani

2015-11-01

Full Text Available Fra l’ultimo scorcio dell’Ottocento e i primi decenni del Novecento Firenze e i suoi dintorni sono il soggetto privilegiato di una grande quantità di descrizioni, note di diario, racconti, opera di scrittori stranieri, in particolare inglesi, che si radicano nell’approdo elettivo di quei luoghi. Il testo presenta la traccia letteraria del paesaggio fiorentino nelle opere di Vernon Lee e Janet Ross, due tipiche rappresentanti di questa tendenza che hanno vissuto, attraverso vicende biografiche in qualche modo parallele, un’esperienza di intensa identificazione con il paesaggio fiorentino. Di Janet Ross, viene commentato Old Florence and Modern Tuscany, volume che raccoglie una serie di articoli pubblicati su alcune riviste inglesi e fornisce una efficace panoramica sull’interesse molto concreto di Janet Ross per il mondo rurale che la vede addirittura impegnata nella gestione della fattoria di Castagnolo, a Lastra a Signa. Più sfaccettato è il commento alle opere di Vernon Lee, di cui sono commentati passi da Vanitas. Polite Stories, Genius Loci, Hortus Vitae and Limbo, in virtù della maggiore ampiezza e complessità del suo mondo culturale. Ne sono cifra distintiva la associazione fra storia e realtà attraverso la dimensione del mistero, che risulta una delle chiavi di acccesso alla bellezza e alla vitalità del paesagggio e la capacità di cogliere il ritmo proprio dei luoghi e di entrare in reale sintonia con essi. 

James Lee Byars 1/2 an autobiography, sourcebook

CERN Document Server

Byars, James Lee; Eleey, Peter

2014-01-01

"I see my autobiography as an arbitrary segment of so many pages of time, of things that I have paid attention to at this point in my life," wrote James Lee Byars (1932-1997) in 1969. He was then 37, about half the average male lifespan at the time, and accordingly thought it appropriate to write his "1/2 autobiography." Byars' art ranged from highly refined objects to extremely minimal performance and events, and books, ephemera and correspondence that he distributed widely among friends and colleagues. Today, more than 15 years after his death, assessments of his art must negotiate Byars' performance of his charismatic self in his life and art. For his first major posthumous survey in the US, exhibition curators Magalí Arriola and Peter Eleey decided to produce a catalogue in two "halves," playing on his "1/2 autobiography": a catalogue of the exhibition itself, including new scholarship, and a sourcebook of primary documents. 1/2 an Autobiography, Sourcebook constitutes the latter volume--a reference guid...

Fungal and enzymatic remediation of a wine lees and five wine-related distillery wastewaters

CSIR Research Space (South Africa)

Strong, PJ

2008-09-01

Full Text Available The alcohol fermentation industry is divided into three main categories: brewing, distilling and wine manufacture. Each of these categories produces wastewaters with com- mon characteristics, such as acidic pH values and high bio- chemical oxygen demand....O. Box 94, Grahamstown 6140, South Africa , Pretoria 0001, South Africa 6 December 2007; accepted 12 December 2007 (2008) xxx–xxx and enzymatic remediation of a wine lees and five ..., Bioresour. e ARTICLE IN PRESS Distillery and wine...

Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension

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Ahn KT

2016-04-01

Full Text Available Kye Taek Ahn, Kwang-In Park, Mi Joo Kim, Jin Kyung Oh, Ji Hye Han, Hee Jin Kwon, Seon-Ah Jin, Jun-Hyung Kim, Jae-Hyeong Park, Jae-Hwan Lee, Si Wan Choi, In-Whan Seong, Jin-Ok Jeong Department of Internal Medicine, Division of Cardiology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Republic of Korea Objectives: Central hemodynamics may better represent the load imposed on the coronary and cerebral arteries and thereby bear a stronger relationship to cardiovascular outcomes. Methods: Patients who had confirmed hypertension as assessed by daytime 24-hour ambulatory blood pressure monitoring (≥135/85 mmHg were enrolled. Central blood pressure and radial augmentation index (AIx corrected for a heart rate of 75 bpm (radial AIx 75 were measured for all patients. We evaluated the association of age, height, and sex with central hemodynamics in patients with never-treated hypertension. Results: A total of 203 patients were enrolled, of whom men numbered 101 (49.7%. The median height of all patients was 162 cm, and mean age was 53.2 years. In the Pearson correlation analysis, regardless of sex difference (R=-0.627 for height, R=0.035 for age, P-value =0.005, a stronger relationship was observed between height and radial AIx 75 than between age and radial AIx 75. In the multiple regression analysis, the sex difference and height were strongly associated with elevated radial AIx 75 in all patients (adjusted R2=0.428, β=6.237, 95% confidence interval [CI] for women 1.480–10.995, P-value =0.011 and β=-0.632, 95% CI for height -0.929 to -0.335, P-value =0.009, respectively. Conclusion: In patients with never-treated hypertension, female sex and shorter height are the important risk factors of elevated radial AIx 75. Keywords: hypertension, augmentation index, height, sex

金批«西厢»美学论%On Aesthetic Thought of Jin Shengtan’ s Comments on The Romance of West Chamber

Institute of Scientific and Technical Information of China (English)

周锡山

2013-01-01

在全面论述金圣叹戏曲美学的基础上，着重论述其“天人合一”、“无和梦”、“通鬼神”和“文有魂”等观点。这些重要观点是以儒、道、佛三家的哲学结合其心得体会而论述的，故而取得了精深的成就。金批«西厢»的鉴赏论是针对普通读者的，艺术论是兼顾读者和作家的，美学论是针对文化修养高的欣赏者和作家诗人的；以上美学观点的阐发，则更是针对文化修养极高的鉴赏者和诗人作家的，高深而玄妙，需要长期反复学习、体会才能掌握。%Based on the comprehensive discussion on Jin Shengtan’ s opera aesthetics,the paper focuses on the theory that heaven-man integration,nature and literature creation, nothing and dream, intercommunion with supernatural beings, and the soul in the article. The above views are put forward with combination of Confucianism,Taoism and Buddhism and Jin’ s own stud-y,and accordingly,Jin made profound achievements. Jin’ s appreciation theory on The Romance of West Chamber is aimed at the common readers;his art theory is aimed at both readers and writers; and his aesthetics is aimed at writers and poets with great accomplishments. The paper holds that the explorations of the above aesthetics are aimed at appreciators, writers and poets with great accomplishments,which needs to be repeatedly and further studied.

Sandra Cisneros’s The House on Mango Street: (Collective Memory Resonating from “the Barrio”

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Jelena Nikodinoska

2014-11-01

Full Text Available  “The people I wrote about were real, for the most part, from here and there, now and then, but sometimes three real people would be braided together into one made-up person… I cut apart and stitched together events to tailor the story, gave it shape so it had a beginning, middle, and end, because real life stories rarely come to us complete. Emotions, though, can’t be invented, can’t be borrowed. All the emotions my characters feel, good or bad are mine.” (xxiii Although Sandra Cisneros draws on autobiographical elements in The House on Mango Street (1984, her novella does not stand for an autobiography, but it rather represents a collage of events, characters, and places that independently from one another constitute vignettes. These vignettes are not necessarily chronologically related, yet they make up a whole of voices, stories, colors, and movements that once reverberated along Mango Street. Through her (Cisneros’s stories, Esperanza Cordero’s stories, and Esperanza’s neighbors’ stories, Cisneros conveys the Southwestern Latino experience of the big city and the streets, of the barrios that is. Taking my cue from Cisneros’s “The House on Mango Street,” I will try to examine how personal experiences become memories and those memories transcend into stories. Is what comes from experience and memory that makes writing strong, powerful, persuasive, and to a certain extent relatable? Have Cisneros’s memories, reflected in Esperanza’s living experience and language contributed to the Latino’s collective memory of the life in the barrios coupled with racism, poverty and shame? On that note, I shall see how Maurice Halbwachs’s concept of collective memory applies to Cisneros’ story and the Latino experience, where Latinos’ memory is dependent upon the life in the barrio within which the majority were/are situated.

Enhancement of the dissolution rate and bioavailability of fenofibrate by a melt-adsorption method using supercritical carbon dioxide

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Cha KH

2012-10-01

Full Text Available Kwang-Ho Cha,1,3 Kyung-Jin Cho,3 Min-Soo Kim,4 Jeong-Soo Kim,3 Hee Jun Park,1,3 Junsung Park,1,3 Wonkyung Cho,1,3 Jeong-Sook Park,3 Sung-Joo Hwang1,21Yonsei Institute of Pharmaceutical Sciences, 2College of Pharmacy, Yonsei University, Incheon, Republic of Korea; 3College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea; 4Department of Pharmaceutical Engineering, Inje University, Gimhae, Republic of KoreaBackground: The aim of this study was to enhance the bioavailability of fenofibrate, a poorly water-soluble drug, using a melt-adsorption method with supercritical CO2.Methods: Fenofibrate was loaded onto Neusilin® UFL2 at different weight ratios of fenofibrate to Neusilin UFL2 by melt-adsorption using supercritical CO2. For comparison, fenofibrate-loaded Neusilin UFL2 was prepared by solvent evaporation and hot melt-adsorption methods. The fenofibrate formulations prepared were characterized by differential scanning calorimetry, powder x-ray diffractometry, specific surface area, pore size distribution, scanning electron microscopy, and energy-dispersive x-ray spectrometry. In vitro dissolution and in vivo bioavailability were also investigated.Results: Fenofibrate was distributed into the pores of Neusilin UFL2 and showed reduced crystal formation following adsorption. Supercritical CO2 facilitated the introduction of fenofibrate into the pores of Neusilin UFL2. Compared with raw fenofibrate, fenofibrate from the prepared powders showed a significantly increased dissolution rate and better bioavailability. In particular, the area under the drug concentration-time curve and maximal serum concentration of the powders prepared using supercritical CO2 were 4.62-fold and 4.52-fold greater than the corresponding values for raw fenofibrate.Conclusion: The results of this study highlight the usefulness of the melt-adsorption method using supercritical CO2 for improving the bioavailability of fenofibrate.Keywords: fenofibrate

Numerical Simulation of Wake Effects in the Lee of a Farm of Wave Dragon Wave Energy Converters

DEFF Research Database (Denmark)

Beels, C.; Troch, P.; De Visch, K.

2009-01-01

. In this paper wake effects in the lee of a single Wave Dragon WEC and multiple Wave Dragon WECs are studied in a time-dependent mild-slope equation model. The Wave Dragon WEC is a floating offshore converter of the overtopping type. The water volume of overtopped waves is first captured in a basin above mean...

Sometimes Pursuits Don't Pan Out: Anticipated Destinations and Other Caveats--Comment on Hom, Mitchell, Lee, and Griffeth (2012)

Science.gov (United States)

Bergman, Mindy E.; Payne, Stephanie C.; Boswell, Wendy R.

2012-01-01

Hom, Mitchell, Lee, and Griffeth (2012) presented an extensive review of employee turnover research, reconceptualized the turnover criterion to include multiple destinations, and proposed to expand the predictor domain. They illuminated the multiple destinations employees pursue following turnover. By crossing desire to remain and volitional…

Comparative analysis of nanotechnology awareness in consumers and experts in South Korea

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Kim YR

2014-12-01

Full Text Available Yu-Ri Kim,1 Eun Jeong Lee,1 Sung Ha Park,2 Hyo Jin Kwon,3 Seong Soo A An,4 Sang Wook Son,5 Young Rok Seo,6 Jae-Eun Pie,7 Myoung Yoon,8 Ja Hei Kim,8 Meyoung-Kon Kim1 1Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, South Korea; 2Department of Biochemistry, University of Bath, Bath, UK; 3Department of Medical Education, Korea University Medical School and College, Seoul, South Korea; 4Department of Bionanotechnology, Gachon University, Seongnam, Gyeonggi, South Korea; 5Department of Dermatology, Korea University Medical School and College, Seoul, South Korea; 6Department of Life Science, Institute of Environmental Medicine for Green Chemistry, Dongguk University, Seoul, South Korea; 7Department of Food and Nutrition, College of Science and Engineering, Anyang University, Anyang, Gyeonggi, South Korea; 8Consumers Korea, Seoul, South Korea Purpose: This study examined the need for public communication about nanotechnologies and nanoparticles by providing a comparative analysis of the differences in risk awareness of nanotechnologies and nanoparticles between consumers and experts. Methods: A total of 1,007 consumers and 150 experts participated in this study. A questionnaire was prepared examining their awareness of nanotechnologies and nanomaterials and their view of the necessity for information and education about the latest nanotechnologies and nanomaterials. Results: Our results indicated that the expert group recognized that they knew more than consumers about nanotechnology and that there was a need for relevant education in nanotechnology and nanomaterials among consumers. We found that the consumer group had a more positive attitude toward nanotechnology, even though they did not know much about it. Moreover, the consumer group was inconclusive about the type of information on nanotechnology deemed necessary for the public, as well as the suitable party to be responsible for education

Interactive survey of consumer awareness of nanotechnologies and nanoparticles in consumer products in South Korea

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Kim YR

2014-12-01

Full Text Available Yu-Ri Kim,1 Eun Jeong Lee,1 Sung Ha Park,2 Hyo Jin Kwon,3 Seong Soo A An,4 Sang Wook Son,5 Young Rok Seo,6 Jae-Eun Pie,7 Myoung Yoon,8 Ja Hei Kim,8 Meyoung-Kon Kim1 1Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, South Korea; 2Department of Biochemistry, University of Bath, Bath, UK; 3Department of Medical Education, Korea University Medical School and College, Seoul, South Korea; 4Department of Bionanotechnology, Gachon University, Seongnam, South Korea; 5Department of Dermatology, Korea University Medical School and College, 6Department of Life Science, Institute of Environmental Medicine for Green Chemistry, Dongguk University, Seoul, South Korea; 7Department of Food and Nutrition, College of Science and Engineering, Anyang University, Anyang, Korea; 8Consumers Korea, Seoul, South Korea Background: The purpose of our study was to understand consumers' risk awareness and need for relevant information about nanotechnology and nanoparticles contained in products currently being sold in Korea. Methods: One thousand and seven adult consumers (aged 20–50 years were randomly selected from all over South Korea between November 1 and 9, 2010. We surveyed the origin and degree of their concern and their need for information and education regarding nanomaterials. Results: Analysis of the survey results showed no significant differences in responses by sex, age, and level of education, but significant differences were found in responses based on average monthly household income. Our research showed that consumers have vague expectations for and positive image of nanotechnology and nanoproducts but do not clearly understand what they are. In addition, we found that preparing and disseminating information to consumers is required in order to provide correct information about nanotechnology to the public. Conclusion: A communication system should be established among the multiple stakeholders involved

Finite-volume spectra of the Lee-Yang model

Energy Technology Data Exchange (ETDEWEB)

Bajnok, Zoltan [MTA Lendület Holographic QFT Group, Wigner Research Centre for Physics,H-1525 Budapest 114, P.O.B. 49 (Hungary); Deeb, Omar el [MTA Lendület Holographic QFT Group, Wigner Research Centre for Physics,H-1525 Budapest 114, P.O.B. 49 (Hungary); Physics Department, Faculty of Science, Beirut Arab University (BAU),Beirut (Lebanon); Pearce, Paul A. [School of Mathematics and Statistics, University of Melbourne,Parkville, Victoria 3010 (Australia)

2015-04-15

We consider the non-unitary Lee-Yang minimal model M(2,5) in three different finite geometries: (i) on the interval with integrable boundary conditions labelled by the Kac labels (r,s)=(1,1),(1,2), (ii) on the circle with periodic boundary conditions and (iii) on the periodic circle including an integrable purely transmitting defect. We apply φ{sub 1,3} integrable perturbations on the boundary and on the defect and describe the flow of the spectrum. Adding a Φ{sub 1,3} integrable perturbation to move off-criticality in the bulk, we determine the finite size spectrum of the massive scattering theory in the three geometries via Thermodynamic Bethe Ansatz (TBA) equations. We derive these integral equations for all excitations by solving, in the continuum scaling limit, the TBA functional equations satisfied by the transfer matrices of the associated A{sub 4} RSOS lattice model of Forrester and Baxter in Regime III. The excitations are classified in terms of (m,n) systems. The excited state TBA equations agree with the previously conjectured equations in the boundary and periodic cases. In the defect case, new TBA equations confirm previously conjectured transmission factors.

Further Clarifying Proximal Withdrawal States and the Turnover Criterion Space: Comment on Hom, Mitchell, Lee, and Griffeth (2012)

Science.gov (United States)

Maertz, Carl P., Jr.

2012-01-01

In "Reviewing Employee Turnover: Focusing on Proximal Withdrawal States and an Expanded Criterion," Hom, Mitchell, Lee, and Griffeth (2012) brought together many of the most important content and process factors in the employee turnover literature. In this paper, I attempt to clarify the true contributions of this framework for the turnover area…

Silica nanoparticle-based dual imaging colloidal hybrids: cancer cell imaging and biodistribution

Directory of Open Access Journals (Sweden)

Lee H

2015-08-01

Full Text Available Haisung Lee,1 Dongkyung Sung,2 Jinhoon Kim,3 Byung-Tae Kim,3 Tuntun Wang,4 Seong Soo A An,5 Soo-Won Seo,6 Dong Kee Yi4 1Molecular Diagnostics, In Vitro Diagnostics Unit, New Business Division, SK Telecom, 2Department of Life Sciences, Graduate School of Korea University, 3Interdisciplinary Graduate Program of Biomedical Engineering, School of Medicine, Sungkyunkwan University, Samsung Medical Center, 4Department of Chemistry, Myongji University, Seoul, 5Department of Bionanotechnology, Gachon Medical Research Institute, Gachon University, Seongnam, 6Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea Abstract: In this study, fluorescent dye-conjugated magnetic resonance (MR imaging agents were investigated in T mode. Gadolinium-conjugated silica nanoparticles were successfully synthesized for both MR imaging and fluorescence diagnostics. Polyamine and polycarboxyl functional groups were modified chemically on the surface of the silica nanoparticles for efficient conjugation of gadolinium ions. The derived gadolinium-conjugated silica nanoparticles were investigated by zeta potential analysis, transmission electron microscopy, inductively coupled plasma mass spectrometry, and energy dispersive x-ray spectroscopy. MR equipment was used to investigate their use as contrast-enhancing agents in T1 mode under a 9.4 T magnetic field. In addition, we tracked the distribution of the gadolinium-conjugated nanoparticles in both lung cancer cells and organs in mice. Keywords: dual bioimaging, MR imaging, silica colloid, T1 contrast imaging, nanohybrid

The fate of calcium carbonate nanoparticles administered by oral route: absorption and their interaction with biological matrices

Directory of Open Access Journals (Sweden)

Lee JA

2015-03-01

Full Text Available Jeong-A Lee,1,* Mi-Kyung Kim,1,* Hyoung-Mi Kim,2,* Jong Kwon Lee,3 Jayoung Jeong,4 Young-Rok Kim,5 Jae-Min Oh,2 Soo-Jin Choi1 1Department of Food Science and Technology, Seoul Women’s University, Seoul, Republic of Korea; 2Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Wonju, Republic of Korea; 3Hazard Substances Analysis Division, Gwangju Regional Food and Drug Administration, Ministry of Food and Drug Safety, Gwangju, Republic of Korea; 4Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Chungcheongbuk-do, Republic of Korea; 5Department of Food Science and Biotechnology, Kyung Hee University, Yongin, Republic of Korea *These authors contributed equally to this work Background: Orally administered particles rapidly interact with biological fluids containing proteins, enzymes, electrolytes, and other biomolecules to eventually form particles covered by a corona, and this corona potentially affects particle uptake, fate, absorption, distribution, and elimination in vivo. This study explored relationships between the biological interactions of calcium carbonate particles and their biokinetics.Methods: We examined the effects of food grade calcium carbonates of different particle size (nano [N-Cal] and bulk [B-Cal]: specific surface areas of 15.8 and 0.83 m2/g, respectively on biological interactions in in vitro simulated physiological fluids, ex vivo biofluids, and in vivo in gastrointestinal fluid. Moreover, absorption and tissue distribution of calcium carbonates were evaluated following a single dose oral administration to rats.Results: N-Cal interacted more with biomatrices than bulk materials in vitro and ex vivo, as evidenced by high fluorescence quenching ratios, but it did not interact more actively with biomatrices in vivo. Analysis of coronas revealed that immunoglobulin, apolipoprotein, thrombin, and fibrinogen

KANUNISASI FIKIH JINAYAT KONTEMPORER Studi Materi Muatan Qānūn Jināyat Aceh dan Brunei Darussalam

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Samsudin Aziz

2014-10-01

Full Text Available This article will view specifically codification of Islamic Criminal Law in `Muslim community, such as Brunei Darussalam, a country based on Islamic principles, and Aceh is a part of Indonesian territory administratively, granted special autonomy to implement Islamic Sharia. Despite having different qualities, -as a country and a province- both have in common as a political power which apply Islamic Criminal Law. Refer to both qānūn jināyat in Brunei and Aceh, the author’ll explain the substance of the criminal law in both area, while also reinforces the implementation of Islamic Criminal Law in the framework of a modern state. The article concludes that basically the application of Islamic Sharia, particularly the Islamic Criminal Law, is closely related to the situation and socio-political conditions of a community or country. The differences of political system, for example, has contributed to the difference in the output of product or policy made by a particular country or territory. On the other hand, Brunei and the Aceh case show that there has been adjustment Islamic Criminal Law specifically set forth in the books of fiqh (as illustration of the Qur'an and Sunnah with the needs of the community itself

Development of gold nanoparticles coated with silica containing the antibiofilm drug cinnamaldehyde and their effects on pathogenic bacteria

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Ramasamy M

2017-04-01

Full Text Available Mohankandhasamy Ramasamy, Jin-Hyung Lee, Jintae Lee School of Chemical Engineering, Yeungnam University, Gyeongsan, Republic of Korea Abstract: Emerging resistance to antibiotics is a mounting worldwide health concern and increases the need for nonantibiotic strategies to combat infectious diseases caused by bacterial pathogens. In this study, the authors used the antibiofilm activity of the naturally occurring antimicrobial cinnamaldehyde (CNMA conjugated to the surface of gold nanoparticles (GNPs to deliver CNMA efficiently and eradicate biofilms of Gram-negative organisms (enterohemorrhagic Escherichia coli O157:H7, and Pseudomonas aeruginosa, Gram positive (methicillin-sensitive Staphylococcus aureus organisms, and methicillin-resistant Staphylococcus aureus bacteria. CNMA-GNPs containing 0.005% (v/v of CNMA were found to inhibit biofilm formation efficiently. The distributions of nanoparticles in biofilm cells and their biofilm disruption activities, including distorted cell morphology, were determined by transmission electron microscopy. In addition to their antibiofilm activities, CNMA-GNPs attenuated S. aureus virulence and protected Caenorhabditis elegans (C. elegans worms. Here, the authors report the antibiofilm effects of CNMA-GNPs and suggest that they could be used to treat pathogenic bacterial infections in vivo. Keywords: antibiofilm, biocompatible, Caenorhabditis elegans, cinnamaldehyde, gold nanoparticles, Staphylococcus aureus

Characterization of mannoproteins during white wine (Vitis vinifera L. cv. ENCRUZADO ageing on lees with stirring in oak wood barrels and in a stainless steel tank with oak staves

Directory of Open Access Journals (Sweden)

Ana Rodrigues

2012-12-01

Significance and impact of the study: This study is a technological approach of a process largely used by white wine producers who want to market a fresh wine produced with stirring of lees with a woody character. It reports the evolution of mannoproteins through four months of ageing on lees with two different stirring processes that can have a direct impact on the cost of the final product.

Evaluating the performance of the Lee-Carter method and its variants in modelling and forecasting Malaysian mortality

Science.gov (United States)

Zakiyatussariroh, W. H. Wan; Said, Z. Mohammad; Norazan, M. R.

2014-12-01

This study investigated the performance of the Lee-Carter (LC) method and it variants in modeling and forecasting Malaysia mortality. These include the original LC, the Lee-Miller (LM) variant and the Booth-Maindonald-Smith (BMS) variant. These methods were evaluated using Malaysia's mortality data which was measured based on age specific death rates (ASDR) for 1971 to 2009 for overall population while those for 1980-2009 were used in separate models for male and female population. The performance of the variants has been examined in term of the goodness of fit of the models and forecasting accuracy. Comparison was made based on several criteria namely, mean square error (MSE), root mean square error (RMSE), mean absolute deviation (MAD) and mean absolute percentage error (MAPE). The results indicate that BMS method was outperformed in in-sample fitting for overall population and when the models were fitted separately for male and female population. However, in the case of out-sample forecast accuracy, BMS method only best when the data were fitted to overall population. When the data were fitted separately for male and female, LCnone performed better for male population and LM method is good for female population.

Die dagboek van Bertha Marks as ‘n heterotopia, soos verwoord in die kunswerk, The Futility of Writing 24-Page Letters

Directory of Open Access Journals (Sweden)

Leora Farber

2012-11-01

Full Text Available Hierdie artikel ondersoek die konsepsie, historiese konteks en teoretiese raamwerk van Leora Farber se 2010 kunswerk The Futility of Writing 24-Page Letters wat ‘n voortsetting is van haar uitstalling Dis-Location/Re-Location. The Futility of Writing 24-Page Letters val binne die tematiek van Dis-Location/Re-Location, maar beklemtoon één aspek van laasgenoemde, naamlik hoe fin-de-siècle Joodse koloniale immigrante vrouens in Suiderlike-Afrika – soos versinnebeeld in die persona van Bertha Marks (1862–1934 – negentiende-eeuse, Viktoriaanse genderideologieë ervaar het. Hierdie vrouens se lewenservarings het dikwels verset teenoor hul posisies as subjekte van ‘n patriargale sosiale sisteem behels, tog, as vrouens, was hul tegelykertyd medepligtig aan die onderskraging van diskriminerende koloniale ideologieë, en aan die handhawing van die rasse, sosiale en kulturele vooroordele, asook vorms van onderdrukking, wat hierdie ideologieë ingelig het. Daar word geargumenteer dat Bertha Marks ‘n verpersoonlikte heterotopia bewoon het; terwyl sy haar plek binne die struktuur van die rasse- en sosiale vooroordele van die koloniale tydperk ten volle ingeneem het, was sy terselfdertyd beperk deur haar posisionering binne dié raamwerk. Hierdie heterotopiese lewenservaring word weerspieël in die dagboekuittreksels waaruit The Futility of Writing 24-Page Letters bestaan. Daarin word haar teenstrydige posisies as slagoffer, getuie, bystander, meeloper en begunstigde van koloniale onreg en uitbuiting geopenbaar, en aanvaar sy in wisselende mate mede-verantwoordelikheid en mede-aanspreeklikheid vir haar rol en optrede.

W3C director Tim Berners-Lee to be Knighted by Queen Elizabeth web inventor recognized for contributions to internet development

CERN Document Server

2003-01-01

"Tim Berners-Lee, the inventor of the World Wide Web and director of the World Wide Web Consortium (W3C), will be made a Knight Commander, Order of the British Empire (KBE) by Queen Elizabeth" (1/2 page).

76 FR 79228 - Combined Licenses at William States Lee III Nuclear Station Site, Units 1 and 2; Duke Energy...

Science.gov (United States)

2011-12-21

... NUCLEAR REGULATORY COMMISSION [Docket Nos. 52-018 and 52-019; NRC-2008-0170] Combined Licenses at William States Lee III Nuclear Station Site, Units 1 and 2; Duke Energy Carolinas, LLC AGENCY: Nuclear.... SUMMARY: Notice is hereby given that the U.S. Nuclear Regulatory Commission (NRC) and the U.S. Army Corps...

Vernon Lee in the Vatican: the uneasy alliance of aestheticism and archaeology.

Science.gov (United States)

Evangelista, Stefano

2009-01-01

From the 1800s onward, aesthetic critics attempted to free the study of ancient Greek art from the frameworks of institutional education and professionalized criticism. In this process, aestheticism entered an uneasy alliance with archaeology, a discipline that was likewise challenging traditional modes of classical learning practiced in public schools and the old universities. In "The Child in the Vatican" (1881), Vernon Lee -- writing under the influence of Pater and from a position of cosmopolitan female amateurism -- examines the uses of archaeological science in the study of classical art. Her analysis of the sculptures of the Niobe Group at once relies on the archaeological method and asks readers to doubt scientific approaches to art that dim the sublime power of the art object.

Kinoshita-Lee-Nauenberg theorem and soft radiation in gauge theories: Abelian case

International Nuclear Information System (INIS)

Akhoury, R.; Sotiropoulos, M.G.; Zakharov, V.I.

1997-01-01

We present a covariant formulation of the Kinoshita-Lee-Nauenberg (KLN) theorem for processes involving the radiation of soft particles. The role of the disconnected diagrams is explored and a rearrangement of the perturbation theory is performed such that the purely disconnected diagrams are factored out. The remaining effect of the disconnected diagrams results in a simple modification of the usual Feynman rules for the S-matrix elements. As an application, we show that, when combined with the Low theorem, this leads to a proof of the absence of the 1/Q corrections to inclusive processes (such as the Drell-Yan process). In this paper the Abelian case is discussed to all orders in the coupling. copyright 1997 The American Physical Society

The Effects of Input Enhancement on Grammar Learning and Comprehension: A Modified Replication of Lee (2007) with Eye-Movement Data

Science.gov (United States)

Winke, Paula M.

2013-01-01

In his 2007 study "Effects of Textual Enhancement and Topic Familiarity on Korean EFL Students' Reading Comprehension and Learning of Passive Form," Lee demonstrated that learners were better able to correct written sentences that contained incorrect English passive forms after exposure to texts flooded with enhanced (versus…

Brown trout in the Lees Ferry reach of the Colorado River—Evaluation of causal hypotheses and potential interventions

Science.gov (United States)

Runge, Michael C.; Yackulic, Charles B.; Bair, Lucas S.; Kennedy, Theodore A.; Valdez, Richard A.; Ellsworth, Craig; Kershner, Jeffrey L.; Rogers, R. Scott; Trammell, Melissa A.; Young, Kirk L.

2018-04-17

Over the period 2014–2016, the number of nonnative brown trout (Salmo trutta) captured during routine monitoring in the Lees Ferry reach of the Colorado River, downstream of Glen Canyon Dam, began increasing. Management agencies and stakeholders have questioned whether the increase in brown trout in the Lees Ferry reach represents a threat to the endangered humpback chub (Gila cypha), to the rainbow trout (Oncorhynchus mykiss) sport fishery, or to other resources of concern. In this report, we evaluate the evidence for the expansion of brown trout in the Lees Ferry reach, consider a range of causal hypotheses for this expansion, examine the likely efficacy of several potential management interventions to reduce brown trout, and analyze the effects of those interventions on other resources of concern.The brown trout population at Lees Ferry historically consisted of a small number of large fish supported by low levels of immigration from downstream reaches. This population is now showing signs of sustained successful reproduction and is on the cusp of recruiting locally hatched fish into the spawning class, based on analysis with a new integrated population model. The proximate causes of this change in status are a large pulse of immigration in the fall of 2014 and higher reproductive rates in 2015–2017. The ultimate causes of this change are not clear. The pulse of immigrants from downstream reaches in fall 2014 may have been induced by three sequential high-flow releases from the dam in November of 2012–2014, but may also have been the result of a unique set of circumstances unrelated to dam operations. The increase in reproduction may have been the result of any number of changes, including an Allee effect, warmer water temperatures, a decrease in competition from rainbow trout, or fall high-flow releases. Correlations over space and time among predictor variables do not allow us to make a clear inference about the cause of the changes. Under a null causal

Pyrite-coated granite cobbles at Lee Bay, Stewart Island

International Nuclear Information System (INIS)

Brathwaite, R.L.; Skinner, D.N.B.; Faure, K.; Edwards, E.

2014-01-01

On the west side of Lee Bay on the northeast coast of Stewart Island, ventifact cobbles of pyrite-coated granite occur on the beach near the high tide mark and appear to be derived from a sand-cemented gravel deposit that forms a low bank at the back of the beach. The pyrite coat (up to 1 mm thick) completely covers the granitic cobbles and is zoned, with an inner zone of fine-grained colloform pyrite and an outer framboidal zone. Framboidal pyrite is typically formed in anoxic sedimentary environments. Subrounded grains of hematite, ilmenite with hematite blebs, magnetite, feldspar, biotite, quartz and zircon are present in the outer framboidal zone, with some ilmenite and hematite grains being partially replaced by pyrite. The assemblage of ilmenite-hematite-magnetite-biotite-zircon is similar both in mineralogy and size range to that found in heavy mineral beach sands. Sulphur isotope values of the pyrite coat are consistent with formation of the pyrite by microbial sulphate reduction of seawater sulphate. The framboidal texture together with the presence of grains of beach sand in the pyrite coating indicate that it was deposited in a low-temperature sedimentary environment. (author)

Generalized Lee-Wick formulation from higher derivative field theories

International Nuclear Information System (INIS)

Cho, Inyong; Kwon, O-Kab

2010-01-01

We study a higher derivative (HD) field theory with an arbitrary order of derivative for a real scalar field. The degree of freedom for the HD field can be converted to multiple fields with canonical kinetic terms up to the overall sign. The Lagrangian describing the dynamics of the multiple fields is known as the Lee-Wick (LW) form. The first step to obtain the LW form for a given HD Lagrangian is to find an auxiliary field (AF) Lagrangian which is equivalent to the original HD Lagrangian up to the quantum level. Until now, the AF Lagrangian has been studied only for N=2 and 3 cases, where N is the number of poles of the two-point function of the HD scalar field. We construct the AF Lagrangian for arbitrary N. By the linear combinations of AF fields, we also obtain the corresponding LW form. We find the explicit mapping matrices among the HD fields, the AF fields, and the LW fields. As an exercise of our construction, we calculate the relations among parameters and mapping matrices for N=2, 3, and 4 cases.

Using the Light Microscopy Module (LMM) on the International Space Station (ISS), The Advanced Colloids Experiment (ACE) and MacroMolecular Biophysics (MMB)

Science.gov (United States)

Meyer, William; Foster, William M.; Motil, Brian J.; Sicker, Ronald; Abbott-Hearn, Amber; Chao, David; Chiaramonte, Fran; Atherton, Arthur; Beltram, Alexander; Bodzioney, Christopher M.;

Light Microscopy Module: International Space Station Premier Automated Microscope

Science.gov (United States)

Sicker, Ronald J.; Foster, William M.; Motil, Brian J.; Meyer, William V.; Chiaramonte, Francis P.; Abbott-Hearn, Amber; Atherton, Arthur; Beltram, Alexander; Bodzioney, Christopher; Brinkman, John;

AXENIC IN-VITRO NITROGEN AND PHOSPHORUS RESPONSES OF SOME DUTCH MARSH ORCHIDS

NARCIS (Netherlands)

DIJK, E; ECK, N

1995-01-01

Seedlings of Dactylorhiza majalis (Reichb.) Hunt & Summerh., D. praetermissa (Druce) Soo var.junialis (Vermen.) Sengh., D. incarnata (L.) Soo and D. maculata (L.) Soo ssp. maculata were grown axenically in vitro at various concentrations of ammonium nitrate and phosphate to assess the extent of

Data and statistical summaries of background concentrations of metals in soils and streambed sediments in part of Big Soos Creek drainage basin, King County, Washington

Science.gov (United States)

Prych, E.A.; Kresch, D.L.; Ebbert, J.C.; Turney, G.L.

1995-01-01

Twenty-nine soil samples from 14 holes at 9 sites in part of the Big Soos Creek drainage basin in southwest King County, Washington, were collected and analyzed to obtain data on the magnitude and variability of background concentrations of metals in soils. Seven streambed-sediment samples and three streamwater samples from three sites also were collected and analyzed. These data are needed by regulating government agencies to determine if soils at sites of suspected contamination have elevated concentrations of metals, and to evaluate the effectiveness of remediation at sites with known contamination. Concentrations of 43 metals were determined by a total method, and concentrations of 17 metals were determined by a total-recoverable method and two different leaching methods. Metals analyzed for by all methods included most of those on the U.S. Environmental Protection agency list of priority pollutants, plus alluminum, iron, and manganese. Ranges of concentrations of metals determined by the total method are within ranges found by others for the conterminous United States. Concentrations of mercury, manganese, phosphorus, lead, selenium, antimony, and zinc as determined by the total method, and of some of these plus other metals as determined by the other methods were larger in shallow soil (less than 12 inches deep) than in deep soil (greater than 12 inches). Concentrations of metals in streambed sediments were more typical of shallow than deep soils.

Q & A with Ed Tech Leaders: Interview with Curtis J. Bonk, Mimi Miyoung Lee, Thomas C. Reeves, & Thomas H. Reynolds

Science.gov (United States)

Viner, Mark; Gardner, Ellen; Shaughnessy, Michael F.

2016-01-01

Curtis J. Bonk, is Professor of Instructional Systems Technology at Indiana University and President of CourseShare. Mimi Miyoung Lee is Associate Professor in the Department of Curriculum and instruction at the University of Houston. Thomas C. Reeves is Professor Emeritus of Learning, Design, and Technology at the University of Georgia. Thomas H.…

Nobelist TD LEE Scientist Cooperation Network and Scientist Innovation Ability Model

Directory of Open Access Journals (Sweden)

Jin-Qing Fang

2013-01-01

Full Text Available Nobelist TD Lee scientist cooperation network (TDLSCN and their innovation ability are studied. It is found that the TDLSCN not only has the common topological properties both of scale-free and small-world for a general scientist cooperation networks, but also appears the creation multiple-peak phenomenon for number of published paper with year evolution, which become Nobelist TD Lee’s significant mark distinguished from other scientists. This new phenomenon has not been revealed in the scientist cooperation networks before. To demonstrate and explain this new finding, we propose a theoretical model for a nature scientist and his/her team innovation ability. The theoretical results are consistent with the empirical studies very well. This research demonstrates that the model has a certain universality and can be extended to estimate innovation ability for any nature scientist and his/her team. It is a better method for evaluating scientist innovation ability and his/her team for the academic profession and is of application potential.

Application of ultrasound to improve lees ageing processes in red wines.

Science.gov (United States)

Del Fresno, Juan Manuel; Loira, Iris; Morata, Antonio; González, Carmen; Suárez-Lepe, Jose Antonio; Cuerda, Rafael

2018-09-30

Ageing on lees (AOL) is a technique that increases volatile compounds, promotes colour stability, improves mouthfeel and reduces astringency in red wines. The main drawback is that it is a slow process. Several months are necessary to obtain perceptible effects in wines. Different authors have studied the application of new techniques to accelerate the AOL process. Ultrasound (US) has been used to improve different food industry processes; it could be interesting to accelerate the yeast autolysis during AOL. This work evaluates the use of the US technique together with AOL and oak chips for this purpose studying the effects of different oenological parameters of red wines. The results obtained indicate an increase of polysaccharides content when US is applied in wine AOL. In addition, total polyphenol index (TPI) and volatile acidity were not affected. However, this treatment increases the dissolved oxygen affecting the volatile compounds and total anthocyanins. Copyright © 2018 Elsevier Ltd. All rights reserved.

Looking Forward: Texas and Its Elderly. Highlights of the Robert Lee Sutherland Seminar (4th, Austin, Texas, May 12, 1984).

Science.gov (United States)

Coleman, Marion Tolbert, Ed.; And Others

This document presents the program agenda and highlights from the one-day Robert Lee Sutherland Seminar held to examine the current status and the future of the elderly population of Texas. Included is the speech, "The Longevity Revolution" by Robert N. Butler, in which is discussed the gain in life expectancy, the feminization of aging,…

Electromagnetic and Scalar Pion form factor in the Kroll-Lee-Zumino model

International Nuclear Information System (INIS)

Dominguez, C.A.; Jottar, J.I.; Loewe, M.; Willers, B.

2009-01-01

The renormalizable Abelian quantum field theory model of Kroll, Lee, and Zumino is used at the one loop level to compute vertex corrections to the tree-level, Vector Meson Dominance (VMD) electromagnetic pion form factor. These corrections, together with the one-loop vacuum polarization contribution, imply a resulting electromagnetic pion form factor in excellent agreement with data in the whole range of accessible momentum transfers in the space-like region. The time-like form factor, which reproduces the Gounaris-Sakurai formula at and near the rho-meson peak, is unaffected by the vertex correction at order O(g 2 ). The KLZ model is also used to compute the scalar radius of the pion at the one loop level, finding π 2 > S =0.40fm 2 . This value implies for the low energy constant of chiral perturbation theory l-bar 4 =3.4

On Dallas Smythe’s “Audience Commodity”: An Interview with Lee McGuigan and Vincent Manzerolle

Directory of Open Access Journals (Sweden)

Henry Adam Svec

2015-07-01

Full Text Available This interview with Lee McGuigan and Vincent Manzerolle explores some concepts and debates charted by their new co-edited book, The Audience Commodity in a Digital Age: Revisiting a Critical Theory of Commercial Media, which both celebrates and scrutinizes Dallas Smythe’s canonical 1977 essay, “Communications: Blindspot of Western Marxism”. The discussion covers Smythe’s contribution to the field of media studies and the state of current debates pertaining to the theory of the audience commodity, and it also touches on questions of Smythe’s mainstream reception and legacy.

LA PSICOLOGIA PARAGUAYA REPRESENTADA EN LA PSICOLOGIA DE JAMES O. WHITTAKER Y SANDRA J. WHITTAKER

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José E. García

2014-01-01

Full Text Available En 1987 los psicólogos estadounidenses James O. Whittaker y Sandra J. Whittaker publicaron la cuarta edición de su famoso libro Psicología. Este fue uno de los textos de introducción más conocidos y utilizados en América Latina y a través de él muchos miles de estudiantes aprendieron sus primeros conceptos sobre la psicología. Esta edición estaba preparada especialmente para su utilización con los alumnos de habla castellana e introducía numerosos tópicos relacionados a la psicología latinoamericana. Además incluía menciones específicas a algunos psicólogos de la región y sus contribuciones a la psicología. Uno de ellos era José de Jesús Aguirre, psicólogo y sacerdote jesuita y uno de los pioneros de la psicología profesional en el Paraguay. Aguirre aplicó la teoría del filósofo holandés Gerard Heymans y su colaborador el psiquiatra Enno Dirk Wiersma con las modificaciones que unos años más tarde introdujo el psicólogo francés René Le Senne. El propósito de la investigación era el análisis de los rasgos tipológicos característicos en la población paraguaya. Con ello, Aguirre iniciaba el estudio científico de la personalidad en el Paraguay. Este artículo estudia la importancia que corresponde asignar a la investigación de Aguirre como parte del texto introductorio de Whittaker y Whittaker. Se analizan los fundamentos teóricos de la tipología de Heymans-Wiersma-Le Senne y las adaptaciones realizadas por Aguirre, además de su aplicación a una muestra superior a las setecientas personas. Esta provenía de diversos niveles educativos, tanto secundarios como universitarios. En la parte concluyente se analiza la relevancia de Aguirre y su trabajo en el contexto de la psicología paraguaya y latinoamericana.

Impacts of Land-Use and Land-Cover Changes on Water Yield: A Case Study in Jing-Jin-Ji, China

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Suxiao Li

2018-03-01

Full Text Available Knowing the impact of land-use and land-cover (LULC changes on the distribution of water yield (WY is essential for water resource management. Using the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST model, we investigated the spatial-temporal variations of WY from 1990 to 2015 in China’s northern semi-arid region of Beijing–Tianjin–Hebei (Jing-Jin-Ji. We quantified the combined effects of LULC dynamics and climatic variation on WY. Furthermore, we identified the relative contribution of main LULC types to WY. For our study region, the built-up area increased by 35.66% (5380 km2 during the study period. In the meantime, cropland, grassland, and wetland decreased continuously. The expansion of built-up area and decline of vegetated land led to an increase of 1047 million m3 (5.1% in total WY. The impacts of LULC changes on WY were mainly determined by the biophysical characteristics of LULC composition. Vegetated land has relatively lower WY coefficients due to higher rates of evapotranspiration and water infiltration. Built-up areas and bare land have higher WY coefficients as a result of their impermeable surface. The spatial-temporal analysis of WY with specification of WY coefficients by LULC types can facilitate integrated land-use planning and water resource management.

Details of the general numerical solutions of the Friedberg-Lee soliton model for ground and exited states

International Nuclear Information System (INIS)

Koeppel, T.; Harvey, M.

1984-06-01

A new numerical method is applied to solving the equations of motion of the Friedberg-Lee Soliton model for both ground and spherically symmetric excited states. General results have been obtained over a wide range of parameters. Critical coupling constants and critical particle numbers have been determined below which soliton solutions cease to exist. The static properties of the proton are considered to show that as presently formulated the model fails to fit all experimental data for any set of parameters

Further Clarification on the Hom, Mitchell, Lee, and Griffeth (2012) Model: Reply to Bergman, Payne, and Boswell (2012) and Maertz (2012)

Science.gov (United States)

Griffeth, Rodger W.; Lee, Thomas W.; Mitchell, Terence R.; Hom, Peter W.

2012-01-01

In this article, we reply to Bergman, Payne, and Boswell (2012) and Maertz (2012), who commented on our reconceptualization of the employee turnover criterion and proximal withdrawal states (Hom, Mitchell, Lee, & Griffeth, 2012). We agree with some points (e.g., anticipated destinations) but take issue with others (e.g., turnover intentions as…

Samuel Holden Parsons Lee (1772-1863): American physician, entrepreneur and selfless fighter of the 1798 Yellow Fever epidemic of New London, Connecticut.

Science.gov (United States)

Mattie, James K; Desai, Sukumar P

2015-02-01

Samuel Holden Parsons Lee practised medicine at a time when the germ theory of disease had not yet been proposed and antibiotics remained undiscovered. In 1798 he served selflessly as the only physician in town who was willing to battle the Yellow Fever outbreak of New London, Connecticut. Because he practised at the dawn of the age of patent medicine, unfortunately his name also came to be associated with medical quackery. We argue that his contributions have been grossly underestimated. He compounded and vended medications - including bilious pills and bitters - that were gold standards of the day. Moreover, one preparation for treatment of kidney stones led to his sub-specialization in this field and was met with such success that its sale continued for nearly 100 years after his death. While a talented medical man, Lee also had a knack for business, finding success in trading, whaling and real estate. © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Comparison of total polyphenols content and antioxidant potential of wines from ‘Welschriesling’ and ‘Sauvignon Blanc’ varieties during ageing on fine lees

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Jasna Lužar

2016-10-01

Full Text Available Phenolic compounds are key components of wine, since they contribute to wine characteristics such as colour, astringency and bitterness. They also act like antioxidants, with mechanisms involving free-radical scavenging that could prevent cardiovascular diseases and cancer. The aim of the present work was to compare the obtained results of total polyphenols content and antioxidant potential (AOP of several white wines (welschriesling and sauvignon blanc during ageing on fine lees. The total polyphenols content decreased in average for 16.1 % in welschriesling wines and for 18.7 % in sauvignon blanc wines in the period of three months of wine ageing on lees. In the same period AOP of wines decreased in average for 16.0 % in welschriesling wines and for 8.0 % in sauvignon blanc wines. Expectedly, the samples with added oak chips in grape must had higher antioxidant potential than others.

In the spotlight. Interview with Kenneth Lee, Health Economist, University of Leeds, U.K.. Interview by Johannes Stoelwinder.

Science.gov (United States)

Lee, K

1984-01-01

Ken Lee appointed to the staff of the Nuffield Centre, University of Leeds, as Lecturer in Health Economics in 1970. He is now Senior Lecturer and Director of the Master's Programme in Health Service Studies. His main teaching interests are in health planning and health economics, and he has carried out research and written extensively on approaches to health economics, health planning and management, care of the elderly, primary health care, health financing, and emergency health services.

Development of megestrol acetate solid dispersion nanoparticles for enhanced oral delivery by using a supercritical antisolvent process

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Ha ES

2015-08-01

Full Text Available Eun-Sol Ha,1 Jeong-Soo Kim,2 In-hwan Baek,3 Jin-Wook Yoo,1 Yunjin Jung,1 Hyung Ryong Moon,1 Min-Soo Kim1 1College of Pharmacy, Pusan National University, 2Dong-A ST Co Ltd, Yongin, 3College of Pharmacy, Kyungsung University, Busan, South Korea Abstract: In the present study, solid dispersion nanoparticles with a hydrophilic polymer and surfactant were developed using the supercritical antisolvent (SAS process to improve the dissolution and oral absorption of megestrol acetate. The physicochemical properties of the megestrol acetate solid dispersion nanoparticles were characterized using scanning electron microscopy, differential scanning calorimetry, powder X-ray diffraction, and a particle-size analyzer. The dissolution and oral bioavailability of the nanoparticles were also evaluated in rats. The mean particle size of all solid dispersion nanoparticles that were prepared was <500 nm. Powder X-ray diffraction and differential scanning calorimetry measurements showed that megestrol acetate was present in an amorphous or molecular dispersion state within the solid dispersion nanoparticles. Hydroxypropylmethyl cellulose (HPMC solid dispersion nanoparticles significantly increased the maximum dissolution when compared with polyvinylpyrrolidone K30 solid dispersion nanoparticles. The extent and rate of dissolution of megestrol acetate increased after the addition of a surfactant into the HPMC solid dispersion nanoparticles. The most effective surfactant was Ryoto sugar ester L1695, followed by d-a-tocopheryl polyethylene glycol 1000 succinate. In this study, the solid dispersion nanoparticles with a drug:HPMC:Ryoto sugar ester L1695 ratio of 1:2:1 showed >95% rapid dissolution within 30 minutes, in addition to good oral bioavailability, with approximately 4.0- and 5.5-fold higher area under the curve (0–24 hours and maximum concentration, respectively, than raw megestrol acetate powder. These results suggest that the preparation of megestrol

The health care burden of high grade chronic obstructive pulmonary disease in Korea: analysis of the Korean Health Insurance Review and Assessment Service data

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Kim JH

2013-11-01

Full Text Available JinHee Kim,1 Chin Kook Rhee,2 Kwang Ha Yoo,3 Young Sam Kim,4 Sei Won Lee,5 Yong Bum Park,6 Jin Hwa Lee,7 YeonMok Oh,5 Sang Do Lee,5 Yuri Kim,8 KyungJoo Kim,8 HyoungKyu Yoon9 1Office of Health Service Research, National Evidence-Based Healthcare Collaborating Agency, Seoul, Korea; 2Department of Internal Medicine, Seoul St Mary’s Hospital, Catholic University of Korea College of Medicine, Seoul, Korea; 3Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea; 4Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea; 5Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; 6Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea; 7Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Korea; 8Department of Clinical Research Support, National Strategic Coordinating Center for Clinical Research, Seoul, Korea; 9Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St Mary’s Hospital, Catholic University of Korea College of Medicine, Seoul, Korea Background: Patients with high grade chronic pulmonary obstructive disease (COPD account for much of the COPD-related mortality and incur excessive financial burdens and medical care utilization. We aimed to determine the characteristics and medical care use of such patients using nationwide data from the Korean Health Insurance Review and Assessment Service in 2009. Materials and methods: Patients with COPD were identified by searching with the International Classification of Diseases–10th Revision for those using medication. Patients with high grade COPD were selected based on their patterns of tertiary institute visits and medication use. Results: The numbers of patients with high grade COPD increased rapidly

Lee-Carter state space modeling: Application to the Malaysia mortality data

Science.gov (United States)

Zakiyatussariroh, W. H. Wan; Said, Z. Mohammad; Norazan, M. R.

2014-06-01

This article presents an approach that formalizes the Lee-Carter (LC) model as a state space model. Maximum likelihood through Expectation-Maximum (EM) algorithm was used to estimate the model. The methodology is applied to Malaysia's total population mortality data. Malaysia's mortality data was modeled based on age specific death rates (ASDR) data from 1971-2009. The fitted ASDR are compared to the actual observed values. However, results from the comparison of the fitted and actual values between LC-SS model and the original LC model shows that the fitted values from the LC-SS model and original LC model are quite close. In addition, there is not much difference between the value of root mean squared error (RMSE) and Akaike information criteria (AIC) from both models. The LC-SS model estimated for this study can be extended for forecasting ASDR in Malaysia. Then, accuracy of the LC-SS compared to the original LC can be further examined by verifying the forecasting power using out-of-sample comparison.

Improving dissolution and oral bioavailability of pranlukast hemihydrate by particle surface modification with surfactants and homogenization

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Ha ES

2015-06-01

Full Text Available Eun-Sol Ha,1 In-hwan Baek,2 Jin-Wook Yoo,1 Yunjin Jung,1 Min-Soo Kim1 1College of Pharmacy, Pusan National University, 2College of Pharmacy, Kyungsung University, Busan, Republic of Korea Abstract: The present study was carried out to develop an oral formulation of pranlukast hemihydrate with improved dissolution and oral bioavailability using a surface-modified microparticle. Based on solubility measurements, surface-modified pranlukast hemihydrate microparticles were manufactured using the spray-drying method with hydroxypropylmethyl cellulose, sucrose laurate, and water and without the use of an organic solvent. The hydrophilicity of the surface-modified pranlukast hemihydrate microparticle increased, leading to enhanced dissolution and oral bioavailability of pranlukast hemihydrate without a change in crystallinity. The surface-modified microparticles with an hydroxypropylmethyl cellulose/sucrose laurate ratio of 1:2 showed rapid dissolution of up to 85% within 30 minutes in dissolution medium (pH 6.8 and oral bioavailability higher than that of the commercial product, with approximately 2.5-fold and 3.9-fold increases in area under the curve (AUC0→12 h and peak plasma concentration, respectively. Therefore, the surface-modified microparticle is an effective oral drug delivery system for the poorly water-soluble therapeutic pranlukast hemihydrate. Keywords: solubility, wettability, sucrose laurate, cellulose

The administration of long-term high-fat diet in ovariectomized wistar rat (Study on Daily Food Intake, Lee Index, Abdominal Fat Mass and Leptin Serum Levels

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Dita Fitriani

2016-12-01

Conclusion: Serum leptin levels positively correlated with Lee index and abdominal fat mass, but negatively correlated with daily food intake. Administration of long-term high-fat diet in this study cannot induce leptin resistance.

A pharmacokinetic and pharmacodynamic drug interaction between rosuvastatin and valsartan in healthy subjects

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Jung JA

2015-03-01

Full Text Available Jin Ah Jung,1 Soo-Yun Lee,2 Jung-Ryul Kim,1 Jae-Wook Ko,1,2 Seong Bok Jang,3 Su Youn Nam,3 Wooseong Huh1,41Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, 2Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, 3Yuhan Research Institute, Yuhan Corporation, 4Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaPurpose: Valsartan, an angiotensin-receptor blocker, and rosuvastatin, a competitive inhibitor of the 3-hydroxy-3-methylglutaryl coenzyme A reductase, are frequently coadministered to treat patients with hypertension and dyslipidemia. The study reported here sought to evaluate the pharmacokinetic and pharmacodynamic interactions between rosuvastatin and valsartan in healthy Korean subjects. Subjects and methods: Thirty healthy male Korean subjects were administered with rosuvastatin (20 mg/day, valsartan (160 mg/day, and both drugs concomitantly for 4 days in a randomized, open-label, multiple-dose, three-treatment, three-period crossover study. Plasma concentrations of rosuvastatin, N-desmethyl rosuvastatin, and valsartan were determined using validated high-performance liquid chromatography with tandem mass spectrometry. Lipid profiles and vital signs (systolic and diastolic blood pressure and pulse rate were measured for the pharmacodynamic assessment.Results: For rosuvastatin, the geometric mean ratios (90% confidence intervals [CIs] of coadministration to mono-administration were 0.8809 (0.7873-0.9857 for maximum plasma concentration at steady state and 0.9151 (0.8632-0.9701 for area under the concentration–time curve (AUC over a dosing interval at steady state. For valsartan, the geometric mean ratios (90% CIs of those were 0.9300 (0.7946-1.0884 and 1.0072 (0.8893-1.1406, respectively. There were no significant differences in the metabolic ratio of N

Interpretation for ''high''-Tc of the totally interconnected solution of the Ma and Lee model

International Nuclear Information System (INIS)

Wiecko, C.

1988-09-01

The already presented totally interconnected (mean-field) approximation of the Ma and Lee model, pictures very well many ingredients of the present status of comprehension of high-T c superconductors. The picture is that of a disordered grain with variable number of particles available for an attractive on-site pairing interaction, embedded in a reservoir of normal particles which fix the chemical potential. Interesting effect of absence of T c and then a sharp increase and slow decay of T c with disorder appears for weak coupling pairing as compared with the hopping probability for single particles. Interpretation is given in terms of one-particle Anderson localization theory and standard mechanisms. (author). 13 refs, 4 figs

Valence-associated uranium isotope fractionation of uranium enriched phosphate in a shallow aquifer, Lee County, Florida

International Nuclear Information System (INIS)

Weinberg, J.M.; Levine, B.R.; Cowart, J.B.

1993-01-01

The source of anomalously high concentrations of uranium, characterized by U-234/U-238 activity ratios significantly less than unity, in shallow groundwaters of Lee County, Florida, was investigated. Uranium in cores samples was separated into U(IV) and U(VI) oxidation state fractions, and uranium analyses were conducted by alpha spectrometry. Uranium mobility was also studied in selected leaching experiments. Results indicate that mobilization of unusually soluble uranium, present in uranium enriched phosphate of the Pliocene age Tamiami Formation at determined concentrations of up to 729 ppm, is the source for high uranium concentrations in groundwater. In leaching experiments, approximately one-third of the uranium present in the uranium enriched phosphate was mobilized into the aqueous phase. Results of previous investigations suggest that U-234, produced in rock by U-238 decay, is selectively oxidized to U(VI). The uranium enriched phosphate studied in this investigation is characterized by selective reduction of U-234, with a pattern of increasing isotopic fractionation with core depth. As a consequence, U-234/U-238 activity ratios greater than 1.0 in the U(IV) fraction, and less than 1.0 in the U(VI) fraction have developed in the rock phase. In leaching experiments, the U(VI) fraction from the rock was preferentially mobilized into the aqueous phase, suggesting that U-234/U-238 activity ratios of leaching groundwaters are strongly influenced by the isotopic characteristics of the U(VI) fraction of rock. It is suggested that preferential leaching of U(VI), present in selectivity reduced uranium enriched phosphate, is the source for low activity ratio groundwaters in Lee County

Trajectory phase transitions and dynamical Lee-Yang zeros of the Glauber-Ising chain.

Science.gov (United States)

Hickey, James M; Flindt, Christian; Garrahan, Juan P

2013-07-01

We examine the generating function of the time-integrated energy for the one-dimensional Glauber-Ising model. At long times, the generating function takes on a large-deviation form and the associated cumulant generating function has singularities corresponding to continuous trajectory (or "space-time") phase transitions between paramagnetic trajectories and ferromagnetically or antiferromagnetically ordered trajectories. In the thermodynamic limit, the singularities make up a whole curve of critical points in the complex plane of the counting field. We evaluate analytically the generating function by mapping the generator of the biased dynamics to a non-Hermitian Hamiltonian of an associated quantum spin chain. We relate the trajectory phase transitions to the high-order cumulants of the time-integrated energy which we use to extract the dynamical Lee-Yang zeros of the generating function. This approach offers the possibility to detect continuous trajectory phase transitions from the finite-time behavior of measurable quantities.

Origin of the waves in ‘A case-study of mesoscale spectra of wind and temperature, observed and simulated’: Lee waves from the Norwegian mountains

DEFF Research Database (Denmark)

Larsén, Xiaoli Guo; Larsen, Søren Ejling; Hahmann, Andrea N.

2012-01-01

their initiation and ending, propagation, spatial orientation and wavelength, are consistent among the different data sources. This evidence and the key wave parameters derived from the WRF simulation, including the Scorer parameter and wave tilt, all suggest that the waves are lee waves generated by uplift from...

Solutions of simple dual bootstrap models satisfying Lee--Veneziano relation and the smallness of cut discontinuities

International Nuclear Information System (INIS)

Chiu, C.B.; Hossain, M.; Tow, D.M.

1977-07-01

To investigate the t-dependent solutions of simple dual bootstrap models, two general formulations are discussed, one without and one with cut cancellation at the planar level. The possible corresponding production mechanisms are discussed. In contrast to Bishari's formulation, both models recover the Lee-Veneziano relation, i.e., in the peak approximation the Pomeron intercept is unity. The solutions based on an exponential form for the reduced triple-Reggeon vertex for both models are discussed in detail. Also calculated are the cut discontinuities for both models and for Bishari's and it is shown that at both the planar and cylinder levels they are small compared with the corresponding pole residues. Precocious asymptotic planarity is also found in the solutions

LEE SHULMAN: CONTRIBUIÇÕES PARA A INVESTIGAÇÃO DA FORMAÇÃO DOCENTE EM ENFERMAGEM E SAÚDE

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Vânia Marli Schubert Backes

2017-01-01

Full Text Available Objetivo : reflexionar sobre los constructos de conocimiento básico para la enseñanza, fuentes de este conocimiento y el modelo de acción y raciocinio pedagógico de Shulman con miras a la investigación de la formación docente en enfermería y salud. Método : se trata de reflexión articulada en tres secciones: Sobre Lee Shulman; Fuentes y conocimiento básico para la enseñanza; Modelo de acción y raciocinio pedagógico. Resultados: Lee Shulman es un investigador norteamericano, profesor emérito de la Universidad de Standford, y en el artículo titulado Knowledge and teaching: foundations of the new reform, publicado originalmente en 1987, presentó tres constructos para la comprensión e investigación de la práctica docente, que influye desde entonces a investigadores de diversas áreas del conocimiento, como biología, matemáticas, lengua inglesa, música y ciencias sociales, ahora utilizados e insertados también en la investigación en enfermería y salud. Conclusión : se presentaron los constructos, concluyendo que su utilización en la investigación puede contribuir tanto al análisis de la formación y de la práctica docente.

NANOTECHNOLOGY, NANOMEDICINE; ETHICAL ASPECTS

OpenAIRE

G?K?AY, Banu; ARDA, Berna

2015-01-01

Nanotechnology is a field that we often hear of its name nowadays. Altough what we know about it is soo poor, we admire this field of technlogy, moreover some societies even argues that nanotechnology will cause second endustrial revolution. In addition, nanotechnology makes our basic scientific knowledge upside down and is soo powerfull that it is potent in nearly every scientific field. Thereby, it is imposible to say that nanotechnology; which is soo effective on human and human life; will...

Missionary Medicine of Canadian Presbytery and Korean Doctors under Japanese Occupation - focusing Sung-jin and Ham-heung

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Yun-Jung HEO

2015-12-01

Full Text Available In East Asia during the second half of the 19th century, overseas mission work by Protestant churches thrived. Missionaries built schools and hospitals and effectively used them for evangelism. In the 20th century when Social Gospel Movement was expanding, medical work has been recognized as a significant mission service in and by itself. This article reviewed the construction and characteristics of missions work conducted by Canadian Presbytery; missionary doctors and Korean doctors who worked at the mission hospitals; why the missionary medical work had to stop; and career paths taken by Korean doctors upon liberation from Japanese occupation. The Canadian Presbytery missionaries, unlike other denomination missionaries, were rather critical of Imperial Japan, but supportive towards Koreans. This could have stemmed from the reflection of their own experience of once a colony of British Empire and also their value system that promotes egalitarian, democratic and progressive theology. The Sung-jin and Ham-heung Mission Bases were a community, interacting organically as a ‘Triangle of Church, School and Hospital.’ The missionaries mobilized the graduates from Christian schools and organized a Young Men’s Christian Association (YMCA. Some of the graduates were trained to become medical doctors or assistants and worked at mission hospitals. Missionary doctors’ approaches to balancing evangelism and medical practice varied. For example, Robert Grieson went through confusion and struggled to balance conflicting roles as a pastor for evangelism and also as a physician. Kate McMillan, on the other hand, had less burden for evangelism than Grieson, and focused on medical work by taking advantage of the opportunity that, as a woman, she can easily approach Korean women. Still another case was Florence Murray who practised evangelism within the hospital setting, and successfully carried out the role as a hospital administrator, going beyond �

[Missionary Medicine of Canadian Presbytery and Korean Doctors under Japanese Occupation--focusing Sung-jin and Ham-heung].

Science.gov (United States)

Heo, Yun-Jung; Cho, Young-Soo

2015-12-01

In East Asia during the second half of the 19th century, overseas mission work by Protestant churches thrived. Missionaries built schools and hospitals and effectively used them for evangelism. In the 20th century when Social Gospel Movement was expanding, medical work has been recognized as a significant mission service in and by itself. This article reviewed the construction and characteristics of missions work conducted by Canadian Presbytery; missionary doctors and Korean doctors who worked at the mission hospitals; why the missionary medical work had to stop; and career paths taken by Korean doctors upon liberation from Japanese occupation. The Canadian Presbytery missionaries, unlike other denomination missionaries, were rather critical of Imperial Japan, but supportive towards Koreans. This could have stemmed from the reflection of their own experience of once a colony of British Empire and also their value system that promotes egalitarian, democratic and progressive theology. The Sung-jin and Ham-heung Mission Bases were a community, interacting organically as a 'Triangle of Church, School and Hospital.' The missionaries mobilized the graduates from Christian schools and organized a Young Men's Christian Association (YMCA). Some of the graduates were trained to become medical doctors or assistants and worked at mission hospitals. Missionary doctors' approaches to balancing evangelism and medical practice varied. For example, Robert Grieson went through confusion and struggled to balance conflicting roles as a pastor for evangelism and also as a physician. Kate McMillan, on the other hand, had less burden for evangelism than Grieson, and focused on medical work by taking advantage of the opportunity that, as a woman, she can easily approach Korean women. Still another case was Florence Murray who practised evangelism within the hospital setting, and successfully carried out the role as a hospital administrator, going beyond 'women's work' as McMillan did

Association of systolic blood pressure drop with intravenous administration of itraconazole in children with hemato-oncologic disease

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Lee HJ

2015-12-01

Full Text Available Hyeong Jin Lee,1,* Bongjin Lee,2,* June Dong Park,2 Hyung Joo Jeong,2 Yu Hyeon Choi,2 Hee Young Ju,1 Che Ry Hong,1 Ji Won Lee,1 Hyery Kim,1 Dong In Suh,3 Kyung Duk Park,1 Hyoung Jin Kang,1 Hee Young Shin,1 Hyo Seop Ahn1 1Department of Pediatrics, Cancer Research Institute, 2Division of Pediatric Intensive Care, Department of Pediatrics, 3Division of Pulmonology, Department of Pediatrics, Seoul National University College of Medicine, Seoul National University, Seoul, South Korea *These authors contributed equally to this work Purpose: Although few adverse effects have been reported for itraconazole, a widely used antifungal therapy for febrile neutropenia, we found intravenous (IV itraconazole to be associated with serious cases of blood pressure (BP drop. We therefore evaluated the incidence and risk factors for BP drop during IV administration of the drug.Materials and methods: We reviewed the medical records of children with hemato-oncologic disease who were treated with IV itraconazole from January 2012 to December 2013. By analyzing systolic BP (SBP measurements made from 4 hours before through to 4 hours after itraconazole administration, we evaluated the changes in SBP and the risk factors for an SBP drop, especially clinically meaningful (≥20% drops.Results: Itraconazole was administered 2,627 times to 180 patients. The SBP during the 4 hours following itraconazole administration was lower than during the 4 hours before administration (104 [53.0–160.33 mmHg] versus 105 [59.8–148.3 mmHg]; P<0.001. The decrease in SBP was associated with the application of continuous renal replacement therapy (CRRT (P=0.012 and the use of inotropic (P=0.005 and hypotensive drugs (P=0.021. A clinically meaningful SBP drop was seen in 5.37% (141 out of 2,627 of the administrations, and the use of inotropics (odds ratio [OR] 6.70, 95% confidence interval [CI] 3.22–13.92; P<0.001, reducing the dose of inotropics (OR 8.08; 95% CI 1.39–46.94; P=0

Crescimento de Hymenaea courbaril L. var. stilbocarpa (Hayne Lee et Lang. e Enterolobium contortisiliquum (Vell. Morong (Leguminosae sob diferentes níveis de sombreamento Growth of Hymenaea courbaril L. var. stilbocarpa (Hayne Lee et Lang. e Enterolobium contortisiliquum (Vell. Morong (Leguminosae under different shading levels

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Ana Lúcia da Silva Lima

2010-03-01

Full Text Available Hymenaea courbaril L. var. stilbocarpa (Hayne Lee et Lang. é uma espécie clímax tolerante a sombra, ao passo que Enterolobium contortisiliquum (Vell. Morong. é uma espécie pioneira. O desenvolvimento destas espécies pode refletir a habilidade de adaptação aos diferentes fatores ambientais (luz, água e temperatura no local em que estão crescendo. O suprimento inadequado de um desses fatores pode reduzir o vigor da planta e limitar seu desenvolvimento. O presente trabalho teve como objetivo avaliar os efeitos do nível de sombreamento no crescimento e a concentração de pigmentos fotossintéticos em duas espécies de leguminosas arbóreas, Hymenaea courbaril L. var. stilbocarpa (Hayne Lee et Lang. e Enterolobium contortisiliquum (Vell. Morong. O experimento foi conduzido no Setor de Olericultura do Centro Universitário Luterano de Ji-Paraná (CEULJI/ULBRA/Rondônia. Durante a formação das mudas, ambas as espécies foram expostas a quatro tratamentos de sombra: 0 % (controle - sol pleno; 30 %; 50 % e 80 %. Cada tratamento foi constituído com três repetições de cada espécie; o delineamento experimental foi inteiramente casualisado. Quatro meses após a semeadura, as seguintes análises foram realizadas: número de folhas, altura da planta, comprimento do sistema radicular, massa seca total e concentração de pigmentos fotossintéticos. O tratamento sob sol pleno afetou negativamente o crescimento de ambas as espécies. As mudas crescidas sob 50% e 80% apresentaram melhor desenvolvimento. Conforme o aumento do sombreamento houve um decréscimo na razão clorofila a/b e um aumento nas concentrações de clorofila total e carotenóides totais.Hymenaea courbaril L. var. stilbocarpa (Hayne Lee et Lang. is a clímax shadow tolerant specie and Enterolobium contortisiliquum (Vell. Morong., by the other hand, is considered as a pioneer specie. The development of these species may reflect its adaptation ability to different environmental

Effect of Saccharomyces strains on the quality of red wines aged on lees.

Science.gov (United States)

Loira, I; Vejarano, R; Morata, A; Ricardo-da-Silva, J M; Laureano, O; González, M C; Suárez-Lepe, J A

2013-08-15

Ageing on lees involves ageing the wine in contact with yeast cells after fermentation. If combined with the addition of oak chips, it can soften the wood flavour and increase the aromatic complexity of wine. The aim of the present work is to optimise both ageing techniques through selection of an adequate Saccharomyces cerevisiae strain. The study lasted 6 months and content of polysaccharides, anthocyanins, proanthocyanidins, volatile compounds, colour parameters and sensory analysis, were periodically evaluated. Among the strains tested, G37 showed the highest release of polysaccharides (24.4±5.5 mg l(-1)). Vanillin, syringaldehyde and furfuryl alcohol increased with ageing time in 7VA2 treatment. The wine aged with CTPL14 strain presented fewer monomeric and oligomeric proanthocyanidins (12.4±0.6 and 83.4±8.3 mg l(-1), respectively), and showed the lowest astringency and bitterness sensations. Results show an improvement in the sensory profile of the red wine aged with a combination of these two techniques. Copyright © 2013 Elsevier Ltd. All rights reserved.

Natural oxygenation of Champagne wine during ageing on lees: A metabolomics picture of hormesis.

Science.gov (United States)

Roullier-Gall, Chloé; Witting, Michael; Moritz, Franco; Gil, Ryan B; Goffette, Delphine; Valade, Michel; Schmitt-Kopplin, Philippe; Gougeon, Régis D

2016-07-15

The oxygenation of Champagne wine after 4 and 6 years of aging on lees in bottle was investigated by FTICR-MS and UPLC-Q-TOF-MS. Three levels of permeability were considered for the stoppers, ranging from 0.2 to 1.8 mg/L/year of oxygen transfer rate. Our results confirmed a good repeatability of ultra-high resolution FTICR-MS, both in terms of m/z and coefficient of variation of peak intensities among biological replicates. Vintages appeared to be the most discriminated features, and metabolite annotations suggested that the oldest wines (2006) were characterized by a higher sensitivity towards oxygenation. Within each vintage, the oxygenation mechanisms appeared to be different for low and high ingresses of oxygen, in agreement with the hormesis character of wine oxygenation. In the particular case of single variety wines and for a given level of stopper permeability, our results also showed that variety discrimination could be easily achieved among wines. Copyright © 2016 Elsevier Ltd. All rights reserved.

High coronary calcium score and post-procedural CK-MB are noninvasive predictors of coronary stent restenosis

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Lee JB

2017-02-01

Full Text Available Jae-Beom Lee,1 Yun-Seok Choi,2 Woo-Baek Chung,2 Ami Kwon,2 Chul-Soo Park,2 Man-Young Lee2 1Anyang Sam Hospital, 2Division of Cardiology, Department of Internal Medicine, Youido St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Purpose: High coronary calcium score (CCS and post-procedural cardiac enzyme may be related with poor outcomes in patients with coronary stent implantation. Methods: A total of 1,072 patients (63.2% male, mean age: 61.7±10.3 years who underwent coronary multi-detect computed tomography at index procedure and follow-up coronary angiography (CAG after drug-eluting stent (DES were divided into two groups: those with and without target lesion revascularization (TLR; >50% reduction in luminal stent diameter or angina symptoms on follow-up CAG. The CCSs for predicting stent revascularization were elucidated. Results: There were no significant differences between the two groups with regard to risk factors. The initial CCS was significantly higher in the TLR group (1,102.4±743.7 vs 345.8±51.05, P=0.04. After adjustment of significant factors for TLR, only CCS and post-procedural creatine kinase MB form (CK-MB elevation were significant predictors of coronary artery TLR. Receiver operation curve revealed that >800 in CCS had 69% in sensitivity and 88% in specificity about predicting the TLR. Conclusion: High CCS with post-procedural CK-MB might be the useful predictors for TLR after DES implantation. Keywords: coronary restenosis, drug-eluting stents, calcium, creatine kinase

PENGARUH KEADILAN ORGANISASI TERHADAP KOMITMEN AFEKTIF MELALUI KEPUASAN KERJA PADA PERUSAHAAN PERBANKAN SWASTA DI DKI JAKARTA

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Darra Pradita Hidayat

2016-08-01

Full Text Available This research refers to a previous study conducted by Matthew S. Crow, Chang-Bae Lee Jae-Jin and Joo (2011 and completed by Andy Myhill & Ben Bradford (2012. This research is about “The Impact of Organizational Justice to Affective Commitment mediated by Job Satisfaction on Banking Companies In Jakarta”. The background of this research is to analyze the Affective Commitment as determining factors dedication and loyalty in banking industry. The purpose of this research was to examine the impact of Organizational Justice to Affective Commitment mediated by Job Satisfaction. The design of this research using primary data obtained by distributing questionnaires to 130 employees of Private Bank in Jakarta. Data analysis method used in this research is Structural Equation Model (SEM. The results of this research concluded that there is a positive effect of Organizational Justice, Procedural Justice, Distributive Justice, Interactional Justice against Affective Commitment through Job Satisfaction.

Uudised

Index Scriptorium Estoniae

2007-01-01

Kalev Saare näitus "Portfolio" Võru Linnagaleriis kuni 2. III. Arhitektuurinäitused "Praha kubism" ja Jozhe Plechnik" Eesti Arhitektuurimuuseumis 03.-04. 2007. Tallinnas Soo 4 avatud kunsti- ja sisustusgaleriist SooSoo (galeristid Kadi Kõpper, Ülle Jehe), kus avanäitusena on kuni 17. III väljas Martin Pedaniku graafikaseeria "Kizoo". Hando Tamme maalinäitus "Meie aja kangelased vol 2" Jõhvi Kunstikooli galeriis 5.-31. III. Kunstiteaduste Instituudi Talvefoorum 007 ja muusikaürituste sari Müsteerium 3.-4. III Juurus. Loetletud "Kujundite taaskasutusel" esinejaid

Islandi-elamus

Index Scriptorium Estoniae

2008-01-01

Galeriis SooSoo on müügil islandi noorte disainerite tööd: Gudrun Lilja Gunnlaugsdottiri laserlõiketehnoloogias raamaturiiulid "Fairytale", Ingibjörg Hanna Bjarnadottiri riidepuud "Raven", Tinna Gunnarsdottiri kummist laualinikud "Samurai", Katrin Olina riidenagid "Tree" ja portselannõud

Pehkinud palkseintega luksusvilla / Jana Rand

Index Scriptorium Estoniae

Rand, Jana, 1963-

2005-01-01

Pädaste mõisa (omanikud Imre Sooäär ja Martin Breuer) 350-aastase moonakatemaja renoveerimine puhkemajaks. Nõu ümberehitamiseks andis soome disainer Ristomatti Ratia. Sisekujunduse autor Imre Sooäär, tema kommentaarid. 10 värv. ill

Why Can't They Keep the Book Longer and Do We Really Need to Charge Fines? Assessing Circulation Policies at the Harold B. Lee Library: A Case Study

Science.gov (United States)

Wilson, Duane

2014-01-01

In response to a charge from the library administration, the Circulation Committee of the Harold B. Lee Library at Brigham Young University designed and implemented a thorough assessment of circulation policies. Using multiple assessment methods including surveys, focus groups, and statistical analysis, the committee determined that the…

Tratamento dos distúrbios da voz na doença de Parkinson: o método Lee Silverman

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Dias Alice Estevo

2003-01-01

Full Text Available Alterações discretas na qualidade da voz e da articulação podem ser observadas em fases relativamente iniciais da doença de Parkinson (DP. As alterações da voz e da fala na DP constituem, em conjunto, o que se denomina disartria hipocinética ou disartrofonia e caracterizam-se por monotonia e redução da intensidade da voz, articulação imprecisa e distúrbios do ritmo. Recentemente, foram relatados resultados favoráveis através de método de tratamento intensivo e dirigido especificamente para o tratamento da voz na DP, denominado Lee Silverman Voice Treatment (LSVT®. O objetivo essencial desse método é aumentar a intensidade vocal através do incremento do esforço fonatório. O presente estudo teve por objetivo a caracterização das anormalidades vocais (qualidade vocal, padrão articulatório e inteligibilidade em um grupo de pacientes com DP e a avaliação da resposta terapêutica obtida pela administração do método Lee Silverman. A comparação dos dados de análise acústica, bem como da análise perceptivo-auditiva nos períodos pré e pós-tratamento mostraram modificações estatisticamente significantes após o tratamento. Embora o padrão articulatório tenha se mantido impreciso, os benefícios obtidos pelo tratamento na melhora da qualidade vocal e, sobretudo, na intensidade vocal favoreceram a qualidade da comunicação oral, reduziram os sintomas negativos e adequaram a qualidade vocal às necessidades pessoais e sociais dos indivíduos.

Mass elevation and lee effects markedly lift the elevational distribution of ground beetles in the Himalaya-Tibet orogen.

Science.gov (United States)

Schmidt, Joachim; Böhner, Jürgen; Brandl, Roland; Opgenoorth, Lars

2017-01-01

Mass elevation and lee effects markedly influence snow lines and tree lines in high mountain systems. However, their impact on other phenomena or groups of organisms has not yet been quantified. Here we quantitatively studied their influence in the Himalaya-Tibet orogen on the distribution of ground beetles as model organisms, specifically whether the ground beetle distribution increases from the outer to the inner parts of the orogen, against latitudinal effects. We also tested whether July temperature and solar radiation are predictors of the beetle's elevational distribution ranges. Finally, we discussed the general importance of these effects for the distributional and evolutionary history of the biota of High Asia. We modelled spatially explicit estimates of variables characterizing temperature and solar radiation and correlated the variables with the respective lower elevational range of 118 species of ground beetles from 76 high-alpine locations. Both July temperature and solar radiation significantly positively correlated with the elevational ranges of high-alpine beetles. Against the latitudinal trend, the median elevation of the respective species distributions increased by 800 m from the Himalayan south face north to the Transhimalaya. Our results indicate that an increase in seasonal temperature due to mass elevation and lee effects substantially impact the regional distribution patterns of alpine ground beetles of the Himalaya-Tibet orogen and are likely to affect also other soil biota there and in mountain ranges worldwide. Since these effects must have changed during orogenesis, their potential impact must be considered when biogeographic scenarios based on geological models are derived. As this has not been the practice, we believe that large biases likely exist in many paleoecological and evolutionary studies dealing with the biota from the Himalaya-Tibet orogen and mountain ranges worldwide.

Revealing Interactions between Human Resources, Quality of Life and Environmental Changes within Socially-oriented Observations : Results from the IPY PPS Arctic Project in the Russian North

Science.gov (United States)

Vlasova, Tatiana

2010-05-01

Socially-oriented Observations (SOO) in the Russian North have been carried out within multidisciplinary IPY PPS Arctic project under the leadership of Norway and supported by the Research Council of Norway as well as Russian Academy of Sciences. The main objective of SOO is to increase knowledge and observation of changes in quality of life conditions (state of natural environment including climate and biota, safe drinking water and foods, well-being, employment, social relations, access to health care and high quality education, etc.) and - to reveal trends in human capital and capacities (health, demography, education, creativity, spiritual-cultural characteristics and diversity, participation in decision making, etc.). SOO have been carried out in industrial cities as well as sparsely populated rural and nature protection areas in observation sites situated in different bioms (from coastal tundra to southern taiga zone) of Murmansk, Arkhangelsk Oblast and Republic of Komi. SOO were conducted according to the international protocol included in PPS Arctic Manual. SOO approaches based both on local people's perceptions and statistics help to identify main issues and targets for life quality, human capital and environment improvement and thus to distinguish leading SOO indicators for further monitoring. SOO have revealed close interaction between human resources, quality of life and environmental changes. Negative changes in human capital (depopulation, increasing unemployment, aging, declining physical and mental health, quality of education, loss of traditional knowledge, marginalization etc.), despite peoples' high creativity and optimism are becoming the major driving force effecting both the quality of life and the state of environment and overall sustainability. Human induced disturbances such as uncontrolled forests cuttings and poaching are increasing. Observed rapid changes in climate and biota (ice and permafrost melting, tundra shrubs getting taller and

Barriers to the adoption of energy-saving technologies in the building sector: A survey study of Jing-jin-tang, China

International Nuclear Information System (INIS)

Du, Ping; Zheng, Li-Qun; Xie, Bai-Chen; Mahalingam, Arjun

2014-01-01

The building sector of China currently consumes 20% of the total energy consumption. Studies on barriers to the adoption of building energy-saving technologies are of great significance on implementing policies related to achieving energy-saving goals. This paper studied 15 barriers with the aid of information collected through questionnaires and semi-structured interviews. The respondents were 135 employees working in the Jing-jin-tang area. Based on the results of the factor analysis, the barriers were categorized into five groups: attitudes of stakeholders, policies and regulations, auxiliary resources, profitability, and adaptability of the technologies. Analysis of the entire sample showed that the stakeholders’ reluctance to use was the largest barrier, followed by high initial investment and low profitability. Further analysis showed that the occupation and designation of the respondents and the size of the enterprises that they served influenced their perspectives on the barriers. It was found that architects attributed more importance to the adoption of energy-saving technologies than contractors; barriers confronted by employees of large enterprises and small enterprises were different; managers perceived weaker barriers than frontline employees and were more optimistic about the prospect of building energy-saving technologies. Finally, policy recommendations were proposed based on these in-depth and targeted analyses. - Highlights: • Fifteen barriers to the adoption of energy-saving technologies are discussed. • Surveys are conducted in one of China's most technologically developed area. • The barriers are divided into 5 groups according to the results of factor analysis. • Barriers related to profitability greatly hamper the adoption of the technologies. • Comparative analyses show the background of respondents influence their viewpoints

Application of the Time-Dependent Mild-Slope Equations for the Simulation of Wake Effects in the Lee of a Farm of Wave Dragon Wave Energy Converters

DEFF Research Database (Denmark)

Beels, Charlotte; Troch, Peter; Visch, Kenneth De

2010-01-01

the wake effect is decreasing with increasing directional spreading. The wake in the lee of a farm of five Wave Dragon WECs, installed in a staggered grid (3 WECs in the first row and 2 WECs in the second row), is calculated for three in-between distances of respectively D, 2D and 3D, with D the distance...

Kanna hy kô hystoe, Joanie Galant-hulle en

African Journals Online (AJOL)

Owner

Vermeulen (3) beskryf dié agtergrond soos volg: “Kanna hy kô hystoe(1965) wortel, soos. Adam Small se ... ten opsigte van die titelkarakters in Van Wyk Louw se dramas Dias(1952) en Germanicus ...... tesis, U van Witwatersrand, 1984. Olivier ...

Factors that influence the selection of learning opportunities for ...

African Journals Online (AJOL)

Sekere knelpunte het egter opgeduik wat as temas beskryf is, naamlik: Bestuursknelpunte, Onderrigknelpunte. Wat betref ";bestuursknelpunte"; as tema is verskeie kategorieë soos werkslading, verpleegtekorte, en kommunikasie probleme geïdentifiseer. Die tema ";onderrigknelpunte"; het kategorieë soos 'n gebrek aan ...

EFFECTS OF MYCORRHIZAL FUNGI ON IN-VITRO NITROGEN RESPONSE OF SOME DUTCH INDIGENOUS ORCHID SPECIES

NARCIS (Netherlands)

DIJK, E; ECK, ND

The effect of mycorrhizal infection on the response to mineral nitrogen was studied in Orchis morio L., Dactylorhiza praetermissa (Druce) Soo var. junialis (Vermin.) Sengh., Dactylorhiza majalis (Reichb.) Hunt & Summerh., and Dactylorhiza incarnara (L.) Soo, using two strains of Ceratorhiza sp. and

Okhee Lee, Cory A. Buxton, James A. Banks (ed.), Diversity and equity in science education: research, policy, and practice

Science.gov (United States)

Bannier, Betsy J.

2015-06-01

Highly relevant for academic study among K-12 educators and the higher education faculty who train pre-service teachers, Diversity and equity in science education highlights three interrelated issues impacting science education in the United States. First, complicated dynamics related to the large and increasing population of English language learning (ELL) students are discussed. Second, the realities of standardized test scores are comparatively explored, both within and beyond the United States. Third, the politics of accountability in education are vigorously discussed. Okhee Lee and Cory A. Buxton weave through the contexts of politics, education, science, and culture to expand existing discourse about how to best educate our nation's children.

Li et al., Afr J Tradit Complement Altern Med. (2013) 10(5):375-379 ...

African Journals Online (AJOL)

cadewumi

-gang, Zhao Jin-ning, Wang Zhi, Li Jin. (2004). Effects of Total Flavone from Drynaria Fortunei on Bone. Density and IL-6, IL-4 and TNFα Levels in Ovariectomized Rats. Chinese Journal of Basic Medicine in Traditional Chinese Medicine, 01:.

Interplay of agency and ownership: the intentional binding and rubber hand illusion paradigm combined.

Directory of Open Access Journals (Sweden)

Niclas Braun

Full Text Available The sense of agency (SoA refers to the phenomenal experience of initiating and controlling an action, whereas the sense of ownership (SoO describes the feeling of myness an agent experiences towards his or her own body parts. SoA has been investigated with intentional binding paradigms, and the sense of ownership (SoO with the rubber-hand illusion (RHI. We investigated the relationship between SoA and SoO by incorporating intentional binding into the RHI. Explicit and implicit measures of agency (SoA-questionnaire, intentional binding and ownership (SoO-questionnaire, proprioceptive drift were used. Artificial hand position (congruent/incongruent and mode of agent (self-agent/other-agent were systematically varied. Reported SoO varied mainly with position (higher in congruent conditions, but also with agent (higher in self-agent conditions. Reported SoA was modulated by agent (higher in self-agent conditions, and moderately by position (higher in congruent conditions. Implicit and explicit agency measures were not significantly correlated. Finally, intentional binding tended to be stronger in self-generated than observed voluntary actions. Results provide further evidence for a partial double dissociation between SoA and SoO, empirically distinct agency levels, and moderate intentional binding differences between self-generated and observed voluntary actions.

Interplay of agency and ownership: the intentional binding and rubber hand illusion paradigm combined.

Science.gov (United States)

Braun, Niclas; Thorne, Jeremy D; Hildebrandt, Helmut; Debener, Stefan

2014-01-01

The sense of agency (SoA) refers to the phenomenal experience of initiating and controlling an action, whereas the sense of ownership (SoO) describes the feeling of myness an agent experiences towards his or her own body parts. SoA has been investigated with intentional binding paradigms, and the sense of ownership (SoO) with the rubber-hand illusion (RHI). We investigated the relationship between SoA and SoO by incorporating intentional binding into the RHI. Explicit and implicit measures of agency (SoA-questionnaire, intentional binding) and ownership (SoO-questionnaire, proprioceptive drift) were used. Artificial hand position (congruent/incongruent) and mode of agent (self-agent/other-agent) were systematically varied. Reported SoO varied mainly with position (higher in congruent conditions), but also with agent (higher in self-agent conditions). Reported SoA was modulated by agent (higher in self-agent conditions), and moderately by position (higher in congruent conditions). Implicit and explicit agency measures were not significantly correlated. Finally, intentional binding tended to be stronger in self-generated than observed voluntary actions. Results provide further evidence for a partial double dissociation between SoA and SoO, empirically distinct agency levels, and moderate intentional binding differences between self-generated and observed voluntary actions.

Impact of the Garrett Lee Smith youth suicide prevention program on suicide mortality.

Science.gov (United States)

Walrath, Christine; Garraza, Lucas Godoy; Reid, Hailey; Goldston, David B; McKeon, Richard

2015-05-01

We examined whether a reduction in youth suicide mortality occurred between 2007 and 2010 that could reasonably be attributed to Garrett Lee Smith (GLS) program efforts. We compared youth mortality rates across time between counties that implemented GLS-funded gatekeeper training sessions (the most frequently implemented suicide prevention strategy among grantees) and a set of matched counties in which no GLS-funded training occurred. A rich set of background characteristics, including preintervention mortality rates, was accounted for with a combination of propensity score-based techniques. We also analyzed closely related outcomes that we did not expect to be affected by GLS as control outcomes. Counties implementing GLS training had significantly lower suicide rates among the population aged 10 to 24 years the year after GLS training than similar counties that did not implement GLS training (1.33 fewer deaths per 100 000; P = .02). Simultaneously, we found no significant difference in terms of adult suicide mortality rates or nonsuicide youth mortality the year after the implementation. These results support the existence of an important reduction in youth suicide rates resulting from the implementation of GLS suicide prevention programming.

Comorbidities in obstructive lung disease in Korea: data from the fourth and fifth Korean National Health and Nutrition Examination Survey

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Park HJ

2015-08-01

Full Text Available Hee Jin Park, Ah Young Leem, Sang Hoon Lee, Ju Han Song, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Kyung Soo Chung Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Institute of Chest Disease, Yonsei University College of Medicine, Seoul, South Korea Background: Comorbidities can occur frequently in patients with chronic obstructive pulmonary disease (COPD and can influence mortality and morbidity independently. It is increasingly recognized that many patients with COPD have comorbidities that have a major impact on their quality of life and survival. Therefore, we investigated the prevalence of comorbidities in Korean COPD populations. Methods: We used data obtained in the 6 years of the fourth and fifth Korean National Health and Nutrition Examination Survey (KNHANES IV and V. Among 50,405 subjects, 16,151 subjects aged ≥40 years who performed spirometry adequately were included in this study. Airway obstruction was defined as forced expiratory volume in 1 second/forced vital capacity <0.7, and the Global Initiative For Chronic Obstructive Lung Disease stage was used to evaluate the severity of airway obstruction. Statistical analyses were performed using SAS 9.2. Results: Among the 16,151 subjects (43.2% male, 56.8% female; mean age: 57.1 years for men and 57.2 years for women, 13.1% had obstructive lung function; 11.3%, restrictive lung function; and 75.6%, normal lung function. Among individuals with obstructive lung function, 45.3%, 49.4%, and 5.3% had mild, moderate, and severe and very severe airflow limitation. The prevalence of hypertension, diabetes mellitus (DM, underweight, and hypertriglyceridemia was higher in the obstructive lung function group than in the normal lung function group (49.6% vs 35.2%; 16.8% vs 10.5%; 3.3% vs 1.3%; 19.7% vs 17.0%. According to the severity of airway obstruction, hypertension and underweight were more common as severity increased

Comparison of methods for calculating thermodynamic properties of binary mixtures in the sub and super critical state: Lee-Kesler and cubic equations of state for binary mixtures containing either CO2 or H2S

International Nuclear Information System (INIS)

Yang, Jyisy; Griffiths, Peter R.; Goodwin, Anthony R.H.

2003-01-01

The (ρ,T,p) and (vapor + liquid) equilibria for fluid mixtures containing either CO 2 or H 2 S have been determined from 13 equations of state. The estimated values have been compared with published experimental results. CO 2 and H 2 S were used to represent non-polar and polar fluids, respectively. The equations of state investigated were as follows: (a) the Lee-Kesler equation; (b) two equations that included new reference fluids for the Lee-Kesler method; (c) three so-called extended equations of state; and (d) seven cubic equations of state. After adjustment of the binary interaction parameters the predicted values differed from the experimental data by about 0.8% for CO 2 mixtures while for H 2 S mixtures the uncertainty was about ±2.8%. Somewhat larger errors, although still lower than ±5%, were obtained for co-existing phase densities; the Lee-Kesler method provided results of the highest accuracy. The cubic equations proposed by Schmidt and Wenzel and Valderrama provide the most reliable predictions of both single and co-existing phase densities. Comparison of the predicted (vapor + liquid) equilibrium with experiment shows that each of the seven cubic equations provides results of similar accuracy and all within ±6%

The viscous lee wave problem and its implications for ocean modelling

Science.gov (United States)

Shakespeare, Callum J.; Hogg, Andrew McC.

2017-05-01

Ocean circulation models employ 'turbulent' viscosity and diffusivity to represent unresolved sub-gridscale processes such as breaking internal waves. Computational power has now advanced sufficiently to permit regional ocean circulation models to be run at sufficiently high (100 m-1 km) horizontal resolution to resolve a significant part of the internal wave spectrum. Here we develop theory for boundary generated internal waves in such models, and in particular, where the waves dissipate their energy. We focus specifically on the steady lee wave problem where stationary waves are generated by a large-scale flow acting across ocean bottom topography. We generalise the energy flux expressions of [Bell, T., 1975. Topographically generated internal waves in the open ocean. J. Geophys. Res. 80, 320-327] to include the effect of arbitrary viscosity and diffusivity. Applying these results for realistic parameter choices we show that in the present generation of models with O(1) m2s-1 horizontal viscosity/diffusivity boundary-generated waves will inevitably dissipate the majority of their energy within a few hundred metres of the boundary. This dissipation is a direct consequence of the artificially high viscosity/diffusivity, which is not always physically justified in numerical models. Hence, caution is necessary in comparing model results to ocean observations. Our theory further predicts that O(10-2) m2s-1 horizontal and O(10-4) m2s-1 vertical viscosity/diffusivity is required to achieve a qualitatively inviscid representation of internal wave dynamics in ocean models.

Urologic symptoms and burden of frailty and geriatric conditions in older men: the Aging Study of PyeongChang Rural Area

Directory of Open Access Journals (Sweden)

Jang IY

2018-02-01

Full Text Available Il-Young Jang,1,2 Chang Ki Lee,3 Hee-Won Jung,4,5 Sang Soo Yu,2 Young Soo Lee,1 Eunju Lee,1 Dae Hyun Kim6,7 1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; 2PyeongChang Health Center & County Hospital, PyeongChang, Gangwon-Do, Republic of Korea; 3Goldman Urology Clinic, Seoul, Republic of Korea; 4Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST, Daejeon, Republic of Korea; 5Geriatric Center, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-Do, Republic of Korea; 6Division of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; 7Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA Purpose: Frailty is an important consideration in the management of lower urinary tract symptoms and erectile dysfunction in older men; frailty increases vulnerability to treatment-related adverse outcomes, but its burden is not known. The authors aimed to examine the burden of frailty and associated geriatric conditions in community-dwelling older men.Patients and methods: A cross-sectional study was conducted with 492 community-dwelling older men (mean age, 74.2 years; standard deviation, 5.6 years. All the participants were administered the International Prostate Symptom Score (IPSS (range: 0–35 and a five-item version of the International Index of Erectile Function (IIEF-5 (range: 5–25. Frailty phenotype was assessed based on exhaustion, inactivity, slowness, weakness, and weight loss. Prevalence of frailty phenotype and geriatric conditions were assessed by the IPSS severity category (mild, 0–7; moderate, 8–19; severe, 20–35 points and the first IIEF-5 question, which assesses the confidence in erectile function (low, 1–2; moderate, 3; high, 4–5 points.Results: Older men with severe urologic

Identity as Fleeting Fashion? Revealing the Background of Popularity Through Bosniaherzegovina’s Adoption of Bruce Lee

Directory of Open Access Journals (Sweden)

Alenka Bartulović

2007-12-01

Full Text Available This paper reflects on the background to popular research on identification processes in modern ethnology and cultural or social anthropology. By discussing themes closely connected to identity (national and popular culture, and the construction of Others, the author reveals that identity is not merely a redundant trend that researchers recklessly pursue, but that it reflects the need to reveal existing uncertainties and is an attempt to revise errors made to date, as well as lapses of the discipline we work in. The author primarily focuses on national identity and its situational transformations and intertwining with other existing identities. Bosnia-Herzegovina is placed at the center of interest. This theoretically oriented text concludes by analyzing the idea of erecting a monument to Bruce Lee in Mostar, which reveals the full complexity of identity processes around a world marked by intense and unique global and transnational currents.

Disainiöös / Kaija-Luisa Kurik

Index Scriptorium Estoniae

Kurik, Kaija-Luisa

2008-01-01

26.-28. sept. 2008 Tallinnas toimunud festivalist "Arts and Lights" ja disainiööst "Kummardus loovusele!". Anti üle disainiauhinnad Bruno tootedisaini kategoorias Mare Kelpmanile ning disainiprojekti kategoorias Tarmo Luisule. Islandi disaini näitusest Kultuurikatlas ja poola disaini näitusest SooSoo galeriis. Üritusest Pecha Kucha Night

Die huwelik in die eerste-eeuse Mediterreense wêreld (I): Vroue in ...

African Journals Online (AJOL)

p1243322

huwelikstrategie gekoppel aan sekere tydperke in die geskiedenis van Israel en die Jodedom. .... eeuse Mediterreense wêreld soos volg: “Unlike our Western guilt-focused society, the pivotal value of the ... soos volg: “[Honor] is recognized as the 'pivotal value' of the ancient Mediterranean world, and 'love of honor' ...

The Taiwanese Perspective in Investigating Korean Confucianism: Lee Ming-huei's Interpretation of Han Wonjin (1682–1750

Directory of Open Access Journals (Sweden)

Martina GREIF

2014-12-01

Full Text Available Numerous representatives of the contemporary Confucian revival from Taiwan are increasingly demonstrating the fact that the development of Confucian philosophy has to be viewed in a broader cultural context, especially in the context of different East Asian regions. While the development of the Japanese Confucian studies has been elaborated to a great extent during the last decades, studies in Korean Confucianism are still rare. Hence, the present article aims to offer a report on a pioneer contribution in this regard. It introduces Lee Ming-huei’s investigation into the work of one of the most influential Korean Confucians of the Joseon period; on the basis of Huang Chun-chieh’s methodology which exposes the contextualization paradigm, the article explains the main hypotheses and offers a theoretical reflection of the main issues discussed in this research work.

"Loomakari" kui uue ühiskonnakorralduse näide / Ernest Truely ; tõlkinud Ulla Juske

Index Scriptorium Estoniae

Truely, Ernest

2009-01-01

Sandra Jõgeva kuraatoriprojektist "Loomakari" Tallinna Kunstihoones, avatud 12. aprillini. Kujundaja Tanel Saar. Sandra Jõgeva, Tanel Saare, Anthony Faroux' (Inglismaa), Jenni Juulia Wallinheimo (Soome) ja Kjetil Kauslandi (Norra) töödest

Tase '08 - kui tase siis ikkagi? / Maarin Ektermann

Index Scriptorium Estoniae

Ektermann, Maarin

2008-01-01

Eesti Kunstiakadeemia lõputööde näitustest, mis toimuvad festivali "Tase '08" raames: vabade kunstide teaduskonna magistritööde väljapanekust Kumu Kunstimuuseumis; disainiteaduskonna lõputööde, mis valmisid koostöös IT Kolledzhi üliõpilastega, näitusest "Arukalt" "SooSoo" galeriis

Structure analysis and core community detection of embodied resources networks among regional industries

Science.gov (United States)

He, Xijun; Dong, Yanbo; Wu, Yuying; Wei, Guodan; Xing, Lizhi; Yan, Jia

2017-08-01

To address the double pressure of scarce resources and regional industrial isomorphism, this paper applied the concepts of exergy and embodied resources based on economic input-output (I-O) data. We constructed the embodied resources networks among the regional industries of Beijing-Tianjin-Hebei (also known as Jing-Jin-Ji) in China. We analyzed the rules of embodied resources consumption in the area's industries, identified the core community structures, and studied the characteristics of industrial homogeneity through regional comparisons. The results showed that the dependence on scarce resources of industrial operations in Beijing was less than in Jin-Ji, while the dependence on finance, technology, information, and other service resources in Beijing was higher than in Jin-Ji. The I-O efficiency of embodied resources among industries and the agglomeration of correlation relationships in industries with large embodied resources were higher than in Jin-Ji. The industrial coincidence degree in the ;bridge; industries and in the core community in Jin-Ji was higher than in Jing-Jin and Jing-Ji, which means the industrial homogeneous competition of Jin-Ji was higher, too. This study makes a significant contribution toward promoting the dislocation development of regional industries, accelerating the coordination of resources, and reducing homogeneity competition.

Design of a gelatin microparticle-containing self-microemulsifying formulation for enhanced oral bioavailability of dutasteride

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Baek I

2015-06-01

Full Text Available In-hwan Baek,1,* Eun-Sol Ha,2,* Jin-Wook Yoo,2 Yunjin Jung,2 Min-Soo Kim21College of Pharmacy, Kyungsung University, 2College of Pharmacy, Pusan National University, Busan, Republic of Korea*These authors contributed equally to this workAbstract: In this study, a gelatin microparticle-containing self-microemulsifying formulation (SMF was developed using a spray-drying method to enhance the oral delivery of the poorly water-soluble therapeutic dutasteride. The effect of the amount of gelatin and the type and amount of hydrophilic additives, namely, Gelucire® 44/14, poloxamer 407, sodium lauryl sulfate, Soluplus®, Solutol™ HS15, and D-α-tocopheryl polyethylene glycol 1000 succinate, on the droplet size, dissolution, and oral absorption of dutasteride from the SMF was investigated. Upon dispersion of the gelatin microparticle-containing SMF in water after spray-drying, the mean droplet size of the aqueous dispersion was in the range of 110–137 nm. The in vitro dissolution and recrystallization results showed that gelatin could be used as a solid carrier and recrystallization inhibitor for the SMF of dutasteride. Furthermore, combination of the gelatin microparticle-containing SMF and Soluplus enhanced the dissolution properties and oral absorption of dutasteride. The results of our study suggest that the gelatin microparticle-containing SMF in combination with Soluplus could be useful to enhance the oral absorption of dutasteride.Keywords: dissolution, solubility, bioavailability, dutasteride

Increased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation

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Al-Amin M

2016-12-01

Full Text Available Md Al-Amin, Jiafu Cao, Muhammad Naeem, Hasanul Banna, Min-Soo Kim, Yunjin Jung, Hae Young Chung, Hyung Ryong Moon, Jin-Wook Yoo College of Pharmacy, Pusan National University, Busan, South Korea Abstract: Hyperpigmentation caused by melanin overproduction is a major skin disorder in humans. Inhibition of tyrosinase, a key regulator of melanin production, has been used as an effective strategy to treat hyperpigmentation. In this study, we investigated the use of solid lipid nanoparticles (SLNs as a highly effective and nontoxic means to deliver a newly synthesized potent tyrosinase inhibitor, MHY498, and to target melanocytes through the skin. MHY498-loaded SLNs (MHY-SLNs were prepared by an oil-in-water emulsion solvent-evaporation method, and their morphological and physicochemical properties were characterized. MHY-SLNs showed a prolonged drug-release profile and higher skin permeation than that of MHY solution. In an in vivo evaluation of antimelanogenic activity, MHY-SLNs showed a prominent inhibitory effect against ultraviolet B-induced melanogenesis, resulting in no change in the skin color of C57BL/6 mouse, compared with that observed in an MHY solution-treated group and an untreated control group. The antimelanogenic effect of MHY-SLNs was further confirmed through Fontana–Masson staining. Importantly, MHY-SLNs did not induce any toxic effects in the L929 cell line. Overall, these data indicate that MHY-SLNs show promise in the topical treatment of hyperpigmentation. Keywords: melanogenesis, hyperpigmentation, MHY498, solid lipid nanoparticles, skin delivery

Systematic identification of yeast proteins extracted into model wine during aging on the yeast lees.

Science.gov (United States)

Rowe, Jeffrey D; Harbertson, James F; Osborne, James P; Freitag, Michael; Lim, Juyun; Bakalinsky, Alan T

2010-02-24

Total protein and protein-associated mannan concentrations were measured, and individual proteins were identified during extraction into model wines over 9 months of aging on the yeast lees following completion of fermentations by seven wine strains of Saccharomyces cerevisiae. In aged wines, protein-associated mannan increased about 6-fold (+/-66%), while total protein only increased 2-fold (+/-20%), which resulted in a significantly greater protein-associated mannan/total protein ratio for three strains. A total of 219 proteins were identified among all wine samples taken over the entire time course. Of the 17 "long-lived" proteins detected in all 9 month samples, 13 were cell wall mannoproteins, and four were glycolytic enzymes. Most cytosolic proteins were not detected after 6 months. Native mannosylated yeast invertase was assayed for binding to wine tannin and was found to have a 10-fold lower affinity than nonglycosylated bovine serum albumin. Enrichment of mannoproteins in the aged model wines implies greater solution stability than other yeast proteins and the possibility that their contributions to wine quality may persist long after bottling.

Mesophilic and thermophilic anaerobic co-digestion of winery wastewater sludge and wine lees: An integrated approach for sustainable wine production.

Science.gov (United States)

Da Ros, C; Cavinato, C; Pavan, P; Bolzonella, D

2017-12-01

In this work, winery wastes generated by a cellar producing approximately 300,000 hL of wine per year was monitored for a period of one year. On average, 196 L of wastewater, 0.1 kg of waste activated sludge (dry matter) and 1.6 kg of wine lees were produced per hectoliter of wine produced. Different winery wastes, deriving from different production steps, namely waste activated sludge from wastewater treatment and wine lees, were co-treated using an anaerobic digestion process. Testing was conducted on a pilot scale for both mesophilic and thermophilic conditions. The process was stable for a long period at 37 °C, with an average biogas production of 0.386 m 3 /kg COD fed . On the other hand, for thermophilic conditions, volatile fatty acids accumulated in the reactor and the process failed after one hydraulic retention time (23 days). In order to fix the biological process, trace elements (iron, cobalt and nickel) were added to the feed of the thermophilic reactor. Metals augmentation improved process stability and yields at 55 °C. The pH ranged between 7.8 and 8.0, and specific gas production was 0.450 m 3 /kg COD fed , which corresponded to dry matter and COD removals of 34% and 88%, respectively. Although the observed performances in terms of biogas production were good, the thermophilic process exhibited some limitations related to both the necessity of metals addition and the worse dewaterability properties. In fact, while the mesophilic digestates reached a good dewatering quality via the addition of 6.5 g of polymer per kg of dry matter, the required dosage for the thermophilic sludge was greater than 10 g/kg of dry matter. Copyright © 2016 Elsevier Ltd. All rights reserved.

Diagnosis of prostate cancer via nanotechnological approach

Directory of Open Access Journals (Sweden)

Kang BJ

2015-10-01

Full Text Available Benedict J Kang,1,2,* Minhong Jeun,1,2,* Gun Hyuk Jang,1,2 Sang Hoon Song,3 In Gab Jeong,3 Choung-Soo Kim,3 Peter C Searson,4 Kwan Hyi Lee1,2 1KIST Biomedical Research Institute, 2Department of Biomedical Engineering, Korea University of Science and Technology (UST, 3Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; 4Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, USA *These authors contributed equally to this work Abstract: Prostate cancer is one of the leading causes of cancer-related deaths among the Caucasian adult males in Europe and the USA. Currently available diagnostic strategies for patients with prostate cancer are invasive and unpleasant and have poor accuracy. Many patients have been overly or underly treated resulting in a controversy regarding the reliability of current conventional diagnostic approaches. This review discusses the state-of-the-art research in the development of novel noninvasive prostate cancer diagnostics using nanotechnology coupled with suggested diagnostic strategies for their clinical implication.Keywords: bioassay, nanomaterial, nanodevice, PSA, non-PSA biomarker, bodily fluid

Lauren Berlant and Lee Edelman, Sex, Or The Unbearable (Durham: Duke University Press, 2014, pp. 168, ISBN: 9780822355946, £13.99, paperback.

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Hannah Proctor

2014-01-01

Full Text Available 'So few colleges and universities bother to teach human sexuality...so much stigma adheres even to scholarly investigation of sex,' Gayle Rubin lamented in her 1984 essay 'Thinking Sex'. But it was an academic conference on Rubin's work - 'Rethinking Sex', a lavish threeday event, held at the University of Pennsylvania in 2009 - that provided the initial impetus for Lauren Berlant and Lee Edelman to enter into a dialogue on sexuality. The result is Sex, or the Unbearable, published by Duke University Press, the first in a series on queer theory edited by the authors.

Dzhässimaal, avalik loomevabadus / Tui Hirv

Index Scriptorium Estoniae

Hirv, Tui, 1984-

2008-01-01

20. aprillil Tallinna Kunstihoones toimunud üritusest Dzhässimaal, kus improviseeris 20.04.2008 Estonian Guitar Octet koosseisus Jaak Sooäär, Paul Daniel, Robert Jürjendal, Tõnis Leemets, Virgo Sillamaa, Mart Soo, Kalle Tikas ja Tarvo Kaspar Toome. Samal ajal maalisid pilte noored kunstnikud Tallinna kunstikoolist, Sally stuudiost ja Pelgulinna kunstigümnaasiumist

Pädaste mõis pakub nii uut kui vana! / Aale Kask

Index Scriptorium Estoniae

Kask, Aale

2008-01-01

Renoveeritud Pädaste mõisa peahoonest (1875). Omanikud Imre Sooäär ja Martin Breuer. Mõisaansambli restaureerimine toimus aastail 1996-2008. Restaureerimisarhitekt Katrin Etverk. Sisearhitektuur: Imre Sooäär, Kärt Kukkur. Restoranisaal kasvab üle talveaiaks. Kärt Kukkuri, Katrin Etverki ja Ülle Grishakovi kommentaarid. Värv. välisvaade, 14 sisevaadet

Reattachment Zone Characterisation Under Offshore Winds With Flow Separation On The Lee Side Of Coastal Dunes

Science.gov (United States)

Delgado-Fernandez, I.; Jackson, D.; Cooper, J. A.; Baas, A. C.; Lynch, K.; Beyers, M.

2010-12-01

Airflow separation, lee-side eddies and secondary flows play an essential role on the formation and maintenance of sand dunes. Downstream from dune crests the flow surface layer detaches from the ground and generates an area characterised by turbulent eddies in the dune lee slope (the wake). At some distance downstream from the dune crest, flow separates into a reversed component directed toward the dune toe and an offshore “re-attached” component. This reattachment zone (RZ) has been documented in fluvial and desert environments, wind tunnel experiments and numerical simulations, but not yet characterised in coastal dunes. This study examines the extent and temporal evolution of the RZ and its implications for beach-dune interaction at Magilligan, Northern Ireland. Wind parameters were measured over a profile extending from an 11 m height dune crest towards the beach, covering a total distance of 65 m cross-shore. Data was collected using an array of nine ultrasonic anemometers (UAs) deployed in April-May 2010, as part of a larger experiment to capture airflow data under a range of incident wind velocities and offshore directions. UAs were located along the profile (5 m tower spacing) over the beach, which allowed a detailed examination of the RZ with empirical data. Numerical modelling using Computational Fluid Dynamics (CFD) software was also conducted with input data from anemometer field measurements, running over a surface mesh generated from LiDAR and DGPS surveys. Results demonstrate that there is a wind threshold of approximately 5-6 ms-1 under which no flow separation exists with offshore winds. As wind speed increases over the threshold, a flow reversal area is quickly formed, with the maximum extent of the RZ at approximately 3.5 dune heights (h). The maximum extent of the RZ increases up to 4.5h with stronger wind speeds of 8-10 ms-1 and remains relatively constant as wind speed further increases. This suggests that the spatial extent of the RZ is

Topography and vegetation as predictors of snow water equivalent across the alpine treeline ecotone at Lee Ridge, Glacier National Park, Montana, U.S.A.

Science.gov (United States)

Geddes, C.A.; Brown, D.G.; Fagre, D.B.

2005-01-01

We derived and implemented two spatial models of May snow water equivalent (SWE) at Lee Ridge in Glacier National Park, Montana. We used the models to test the hypothesis that vegetation structure is a control on snow redistribution at the alpine treeline ecotone (ATE). The statistical models were derived using stepwise and "best" subsets regression techniques. The first model was derived from field measurements of SWE, topography, and vegetation taken at 27 sample points. The second model was derived using GIS-based measures of topography and vegetation. Both the field- (R² = 0.93) and GIS-based models (R² = 0.69) of May SWE included the following variables: site type (based on vegetation), elevation, maximum slope, and general slope aspect. Site type was identified as the most important predictor of SWE in both models, accounting for 74.0% and 29.5% of the variation, respectively. The GIS-based model was applied to create a predictive map of SWE across Lee Ridge, predicting little snow accumulation on the top of the ridge where vegetation is scarce. The GIS model failed in large depressions, including ephemeral stream channels. The models supported the hypothesis that upright vegetation has a positive effect on accumulation of SWE above and beyond the effects of topography. Vegetation, therefore, creates a positive feedback in which it modifies its, environment and could affect the ability of additional vegetation to become established.

Novel phytoceramides containing fatty acids of diverse chain lengths are better than a single C18-ceramide N-stearoyl phytosphingosine to improve the physiological properties of human stratum corneum

Directory of Open Access Journals (Sweden)

Oh MJ

2017-09-01

Full Text Available Myoung Jin Oh,1 Young Hoon Cho,1 So Yoon Cha,1 Eun Ok Lee,2 Jin Wook Kim,2 Sun Ki Kim,2 Chang Seo Park1 1Department of Chemical and Biochemical Engineering, Dongguk University, Chung-gu, Seoul, 2LCS Biotech, Gwonseon-gu, Suwon-si, Gyeonggi-do, Republic of Korea Abstract: Ceramides in the human stratum corneum (SC are a mixture of diverse N-acylated fatty acids (FAs with different chain lengths. C24 is the major class of FAs of ceramides. However, there are also other classes of ceramides with diverse chain lengths of FAs, and these lengths generally range from C16 to C26. This study aimed to prepare several types of phytoceramide containing diverse chain lengths of N-acylated FAs and compare them with C18-ceramide N-stearoyl phytosphingosine (NP in terms of their effects on the physiological properties of the SC. We chose natural oils, such as horse fat oil, shea butter, sunflower oil, and a mixture of macadamia nut, shea butter, moringa, and meadowfoam seed oil, as sources of FAs and phytosphingosine as a sphingoid backbone to synthesize diverse phytoceramides. Each phytoceramide exhibited a distinctive formation of the lamellar structure, and their FA profiles were similar to those of their respective natural oil. The skin barrier properties, as analyzed in human skin, clearly demonstrated that all the phytoceramides improved the recovery rate of the damaged SC and enhanced hydration better than C18-ceramide NP did. In conclusion, natural oil-derived phytoceramides could represent a novel class of ceramides for cosmetic applications in the development of an ideal skin barrier moisturizer. Keywords: fatty acid, chain length, phytoceramide, skin barrier, natural oil

Neutrino mixing: from the broken μ-τ symmetry to the broken Friedberg–Lee symmetry

International Nuclear Information System (INIS)

Xing, Zhizhong

2007-01-01

I argue that the observed flavor structures of leptons and quarks might imply the existence of certain flavor symmetries. The latter should be a good starting point to build realistic models towards deeper understanding of the fermion mass spectra and flavor mixing patterns. The μ-τ permutation symmetry serves for such an example to interpret the almost maximal atmospheric neutrino mixing angle (θ 23 ~ 45°) and the strongly suppressed CHOOZ neutrino mixing angle (θ 13 < 10°). In this talk I like to highlight a new kind of flavor symmetry, the Friedberg–Lee symmetry, for the effective Majorana neutrino mass operator. Luo and I have shown that this symmetry can be broken in an oblique way, such that the lightest neutrino remains massless but an experimentally-favored neutrino mixing pattern is achievable. We get a novel prediction for θ 13 in the CP-conserving case: sinθ 13 = tanθ 12 |(1 - tanθ 23 )/(1 + tanθ 23 )|. Our scenario can simply be generalized to accommodate CP violation and be combined with the seesaw mechanism. Finally I stress the importance of probing possible effects of μ-τ symmetry breaking either in terrestrial neutrino oscillation experiments or with ultrahigh-energy cosmic neutrino telescopes. (author)

Amet kohustab / Sandra Peetso

Index Scriptorium Estoniae

Peetso, Sandra

2008-01-01

18.-22. okt. Pärnu teatris Endla toimunud rahvusvahelisest laste- ja noorteteatrite festivalist "NB festival 2008". Pikemalt lavastustest "Võimaluste aed" (Prantsuse teatritrupp Association 16 rue de Plaisance), "Sailor & Pekka" (Rootsi teater TRE), "Misantroop" (VAT-teater), "Maria Bonita" (Taani teater Batida), "Avatud ring" (Leedu teatrilabor Open Circle)

Leningradi aktsioonid / Sandra Jõgeva

Index Scriptorium Estoniae

Jõgeva, Sandra, 1976-

2006-01-01

Eesti kunstnike väljapanekust "Empty Spaces and their Occupants" 12.-24. augustini 2006 a. toimuval Peterburi Maneezhi 6. rahvusvahelisel eksperimentaalkunsti festivalil, kuraator Maksim Surin. Osalevad Kaido Ole, Merike Estna, Meeland Sepp jt

Multiobjective Optimization of Linear Cooperative Spectrum Sensing: Pareto Solutions and Refinement.

Science.gov (United States)

Yuan, Wei; You, Xinge; Xu, Jing; Leung, Henry; Zhang, Tianhang; Chen, Chun Lung Philip

2016-01-01

In linear cooperative spectrum sensing, the weights of secondary users and detection threshold should be optimally chosen to minimize missed detection probability and to maximize secondary network throughput. Since these two objectives are not completely compatible, we study this problem from the viewpoint of multiple-objective optimization. We aim to obtain a set of evenly distributed Pareto solutions. To this end, here, we introduce the normal constraint (NC) method to transform the problem into a set of single-objective optimization (SOO) problems. Each SOO problem usually results in a Pareto solution. However, NC does not provide any solution method to these SOO problems, nor any indication on the optimal number of Pareto solutions. Furthermore, NC has no preference over all Pareto solutions, while a designer may be only interested in some of them. In this paper, we employ a stochastic global optimization algorithm to solve the SOO problems, and then propose a simple method to determine the optimal number of Pareto solutions under a computational complexity constraint. In addition, we extend NC to refine the Pareto solutions and select the ones of interest. Finally, we verify the effectiveness and efficiency of the proposed methods through computer simulations.

Prevalence and correlates of suicide ideation in patients with COPD: a mixed methods study

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Fleehart S

2014-12-01

Full Text Available Sara Fleehart,1,* Vincent S Fan,2,3,* Huong Q Nguyen,4 Jungeun Lee,1 Ruth Kohen,3 Jerald R Herting,5 Gustavo Matute-Bello,2,3 Sandra G Adams,6,7 Genevieve Pagalilauan,3 Soo Borson3 1School of Nursing, University of Washington, Seattle, WA, USA; 2VAPuget Sound Health Care Center, Seattle, WA, USA; 3School of Medicine, University of Washington, Seattle, WA, USA; 4Reseach and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA; 5Department of Sociology, University of Washington, Seattle, WA, USA; 6School of Medicine, University of Texas Health Science Center; 7South Texas Veterans Health Care System, San Antonio, TX, USA *These authors contributed equally to this paper Purpose: The purpose of this study was to examine the prevalence and correlates of suicidal ideation (SI in patients with stable moderate to very severe chronic obstructive pulmonary disease (COPD. Patients and methods: We conducted an exploratory mixed methods analysis of data from participants in a longitudinal observational study of depression in COPD. We measured depression with the Patient Health Questionnaire-9 (PHQ-9, which includes an item on SI. We compared participants with and without SI in relation to sociodemographics, symptoms, anxiety, and healthcare resource use with independent t-tests and chi-square tests. Content analysis was performed on qualitative data gathered during a structured SI safety assessment. Results: Of 202 participants, 121 (60% had depressive symptoms (PHQ ≥6; 51 (25% had a PHQ-9 ≥10, indicating a high likelihood of current major depression; and 22 (11% reported SI. Compared to the 99 depressed participants without SI, those with SI were more likely to be female (59% vs 27%, P=0.004; had worse dyspnea (P=0.009, depression (P<0.001, and anxiety (P=0.003; and were also more likely to have received treatment for depression and/or anxiety (82% vs 40%, P<0.001 and more hospitalizations for COPD exacerbations (P=0.03 but had similar

Development of a robust pH-sensitive polyelectrolyte ionomer complex for anticancer nanocarriers

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Lim CM

2016-02-01

Full Text Available Chaemin Lim,1,* Yu Seok Youn,2,* Kyung Soo Lee,1 Ngoc Ha Hoang,1 Taehoon Sim,1 Eun Seong Lee,3 Kyung Taek Oh1 1Department of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University, Seoul, 2Department of Pharmaceutical Sciences, School of Pharmacy, Sungkyunkwan University, Suwon, 3Division of Biotechnology, The Catholic University of Korea, Gyeonggi-do, South Korea *These authors contributed equally to this work Abstract: A polyelectrolyte ionomer complex (PIC composed of cationic and anionic polymers was developed for nanomedical applications. Here, a poly(ethylene glycol–poly(lactic acid–poly(ethylene imine triblock copolymer (PEG–PLA–PEI and a poly(aspartic acid (P[Asp] homopolymer were synthesized. These polyelectrolytes formed stable aggregates through electrostatic interactions between the cationic PEI and the anionic P(Asp blocks. In particular, the addition of a hydrophobic PLA and a hydrophilic PEG to triblock copolyelectrolytes provided colloidal aggregation stability by forming a tight hydrophobic core and steric hindrance on the surface of PIC, respectively. The PIC showed different particle sizes and zeta potentials depending on the ratio of cationic PEI and anionic P(Asp blocks (C/A ratio. The doxorubicin (dox-loaded PIC, prepared with a C/A ratio of 8, demonstrated pH-dependent behavior by the deprotonation/protonation of polyelectrolyte blocks. The drug release and the cytotoxicity of the dox-loaded PIC (C/A ratio: 8 increased under acidic conditions compared with physiological pH, due to the destabilization of the formation of the electrostatic core. In vivo animal imaging revealed that the prepared PIC accumulated at the targeted tumor site for 24 hours. Therefore, the prepared pH-sensitive PIC could have considerable potential as a nanomedicinal platform for anticancer therapy. Keywords: polyelectrolyte ionomer complex, PEG–PLA–PEI, nanomedicine, pH-sensitive, animal imaging

Anmeldelse af: Bruner og de små børns læring

DEFF Research Database (Denmark)

Christensen, Bodil

2013-01-01

Anmeldelse af: Bruner og de små børns læring - en introduktion af Sandra Smidt, Hans Reitzels Forlag, 2013.......Anmeldelse af: Bruner og de små børns læring - en introduktion af Sandra Smidt, Hans Reitzels Forlag, 2013....

IDENTIFICATION OF ODOR SUBSTANCES IN YAMABUSHITAKE MUSHROOM (Hericium erinaceum) CULTURE MEDIA CONTAINING 'SHOCHU' LEES AND STARCH WASTES, AND BASIC STUDIES ON THEIR DISAPPEARANCE

Science.gov (United States)

Yamauchi, Masahito; Matsumoto, Hirotaka; Yamada, Masayoshi; Yagi, Fumio; Murayama, Ryou; Yamaguchi, Yoshinori; Yamaguchi, Takashi

In this study, odor substances from mushroom culture media containing 'shochu' lees and starch wastes were identified and determined. It was apparent that in the media, acetoin, butyric acid and diacetyl were found as main odor substances, and mixed with some other ordor substances to produce unpleasant odor. The main substances disappeared with growth of mycelia. It was not likely that these ordor substances were degraded by extracellular enzymes but suggested that they were degraded by mycelia. Further it was found with the growth of mycelia that odor quality changed from rancid ordor (unpleasant ordor) to mushroom smell (pleasant odor) and the odor index was decreasing.

Lee Sang Gak Telescope (LSGT): A Remotely Operated Robotic Telescope for Education and Research at Seoul National University

Science.gov (United States)

Im, Myungshin; Choi, Changsu; Kim, Kihyun

2015-08-01

We introduce the Lee Sang Gak Telescope (LSGT), a remotely operated, robotic 0.43-meter telescope. The telescope was installed at the Siding Spring Observatory, Australia, in 2014 October, to secure regular and exclusive access to the dark sky and excellent atmospheric conditions in the southern hemisphere from the Seoul National University (SNU) campus. Here, we describe the LSGT system and its performance, present example images from early observations, and discuss a future plan to upgrade the system. The use of the telescope includes (i) long-term monitoring observations of nearby galaxies, active galactic nuclei, and supernovae; (ii) rapid follow-up observations of transients such as gamma-ray bursts and gravitational wave sources; and (iii) observations for educational activities at SNU. Based on observations performed so far, we find that the telescope is capable of providing images to a depth of R=21.5 mag (point source detection) at 5-σ with 15 min total integration time under good obs-erving conditions.

Unexpected Climatological Behavior of MLT Gravity Wave Momentum Flux in the Lee of the Southern Andes Hot Spot

Science.gov (United States)

DeWit, R. J.; Janches, D.; Fritts, D. C.; Stockwell, R. G.; Coy, L.

2017-01-01

The Southern Argentina Agile MEteor Radar (SAAMER), located at Tierra del Fuego (53.7degS, 67.7degW), has been providing near-continuous high-resolution measurements of winds and high-frequency gravity wave (GW) momentum fluxes of the mesopause region since May 2008. As SAAMER is located in the lee of the largest seasonal GW hot spot on Earth, this is a key location to study GWs and their interaction with large-scale motions. GW momentum flux climatologies are shown for the first time for this location and discussed in light of these unique dynamics. Particularly, the large eastward GW momentum fluxes during local winter are surprising, as these observations cannot be explained by the direct upward propagation of expected large-amplitude mountain waves (MWs) through the eastward stratospheric jet. Instead, these results are interpreted as secondary GWs propagating away from stratospheric sources over the Andes accompanying MW breaking over the Southern Andes.

Detergents enhance EspB secretion from Escherichia coli strains harboring the locus for the enterocyte effacement (LEE) gene.

Science.gov (United States)

Nakasone, Noboru; Toma, Claudia; Higa, Naomi; Koizumi, Yukiko; Ogura, Yasunori; Suzuki, Toshihiko

2011-02-01

The effects of detergents (cholic acid, deoxycholic acid, Triton X-100, and Nonidet P-40) on the secretion of EspB from the locus for enterocyte effacement (LEE) gene-positive Escherichia coli strains were examined. Clinical isolates of eight EPEC strains and seven STEC strains were used to detect EspB after they had been cultivated in Luria-Bertani (LB) broth containing one of the detergents. When the bacteria were cultured in LB broth supplemented with one of the detergents, the amount of EspB produced was increased by 2-32-fold depending on the detergent and the strain used. EspB was detected in all strains when they were cultured in LB broth containing all of the detergents. The results obtained in this study can be applied to immunological diagnostic methods for detecting EspB and also to the production of EspB for research purposes. © 2010 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

Joint Institute for Nanoscience Annual Report 2004

Energy Technology Data Exchange (ETDEWEB)

Baer, Donald R.; Campbell, Charles

2005-02-01

Due to the inherently interdisciplinary nature of nanoscience and nanotechnology, research in this arena is often significantly enhanced through creative cooperative activities. The Joint Institute for Nanoscience (JIN) is a venture of the University of Washington (UW) and Pacific Northwest National Laboratory (PNNL) to encourage and enhance high impact and high quality nanoscience and nanotechnology research that leverages the strengths and capabilities of both institutions, and to facilitate education in these areas. This report summarizes JIN award activities that took place during fiscal year 2004 and provides a historical list of JIN awardees, their resulting publications, and JIN-related meetings. Major portions of the JIN efforts and resources are dedicated to funding graduate students and postdoctoral research associates to perform research in collaborations jointly directed by PNNL staff scientists and UW professors. JIN fellowships are awarded on the basis of applications that include research proposals. They have been very successful in expanding collaborations between PNNL and UW, which have led to many excellent joint publications and presentations and enhanced the competitiveness of both institutions for external grant funding. JIN-based interactions are playing a significant role in creating new research directions and reshaping existing research programs at both the UW and PNNL. The JIN also co-sponsors workshops on Nanoscale Science and Technology, four of which have been held in Seattle and one in Richland. In addition to involving PNNL staff in various UW nanoscience courses and seminars, a National Science Foundation grant, Development of UW-PNL Collaborative Curriculums in Nano-Science and Technology, has allowed the development of three intensive short courses that are taught by UW faculty, PNNL staff, and faculty from other institutions, including Washington State University, the University of Idaho, Stanford University, and the University of

Cationic PLGA/Eudragit RL nanoparticles for increasing retention time in synovial cavity after intra-articular injection in knee joint

Directory of Open Access Journals (Sweden)

Kim SR

2015-08-01

Full Text Available Sung Rae Kim,1 Myoung Jin Ho,2 Eugene Lee,3 Joon Woo Lee,3 Young Wook Choi,1 Myung Joo Kang21College of Pharmacy, Chung-Ang University, Dongjak-gu, Seoul, 2College of Pharmacy, Dankook University, Dongnam-gu, Cheonan, Chungnam, 3Department of Radiology, Seoul National University Bundang Hospital, Bundang-gu, Seongnam, Gyeonggi-do, South KoreaAbstract: Positively surface-charged poly(lactide-co-glycolide (PLGA/Eudragit RL nanoparticles (NPs were designed to increase retention time and sustain release profile in joints after intra-articular injection, by forming micrometer-sized electrostatic aggregates with hyaluronic acid, an endogenous anionic polysaccharide found in high amounts in synovial fluid. The cationic NPs consisting of PLGA, Eudragit RL, and polyvinyl alcohol were fabricated by solvent evaporation technique. The NPs were 170.1 nm in size, with a zeta potential of 21.3 mV in phosphate-buffered saline. Hyperspectral imaging (CytoViva® revealed the formation of the micrometer-sized filamentous aggregates upon admixing, due to electrostatic interaction between NPs and the polysaccharides. NPs loaded with a fluorescent probe (1,1'-dioctadecyl-3,3,3',3' tetramethylindotricarbocyanine iodide, DiR displayed a significantly improved retention time in the knee joint, with over 50% preservation of the fluorescent signal 28 days after injection. When DiR solution was injected intra-articularly, the fluorescence levels rapidly decreased to 30% of the initial concentration within 3 days in mice. From these findings, we suggest that PLGA-based cationic NPs could be a promising tool for prolonged delivery of therapeutic agents in joints selectively.Keywords: PLGA, Eudragit RL, hyaluronic acid, cationic nanoparticles, intra-articular injection, electrostatic interaction

A fixed-dose combination tablet of gemigliptin and metformin sustained release has comparable pharmacodynamic, pharmacokinetic, and tolerability profiles to separate tablets in healthy subjects

Directory of Open Access Journals (Sweden)

Park SI

2015-02-01

Full Text Available Sang-In Park,1,* Howard Lee,1,2,* Jaeseong Oh,1 Kyoung Soo Lim,3 In-Jin Jang,1 Jeong-Ae Kim,4 Jong Hyuk Jung,4 Kyung-Sang Yu1 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, 2Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Clinical Trials Center, Seoul National University Hospital, Seoul, 3Department of Clinical Pharmacology and Therapeutics, CHA University School of Medicine and CHA Bundang Medical Center, Seongnam, 4LG Life Sciences, Ltd, Seoul, Republic of Korea *These authors contributed equally to this work Background: In type 2 diabetes mellitus, fixed-dose combination (FDC can provide the complementary benefits of correction of multiple pathophysiologic defects such as dysfunctions in glycemic or metabolic control while improving compliance compared with separate tablets taken together. The objective of the study reported here was to compare the pharmacodynamic (PD, pharmacokinetic (PK, and tolerability profiles of gemigliptin and extended-release metformin (metformin XR between FDC and separate tablets.Methods: A randomized, open-label, single-dose, two-way, two-period, crossover study was conducted in 28 healthy male volunteers. Two FDC tablets of gemigliptin/metformin 25/500 mg or separate tablets of gemigliptin (50 mg ×1 and metformin XR (500 mg ×2 were orally administered in each period. Serial blood samples were collected up to 48 hours post-dose to determine dipeptidyl peptidase 4 (DPP-4 activity using spectrophotometric assay and concentrations of gemigliptin and metformin using tandem mass spectrometry. Geometric mean ratios (GMRs of FDC to separate tablet formulations and their 90% confidence intervals (CIs were calculated to compare the PD and PK parameters between the two formulations. Tolerability was assessed throughout the study.Results: The plasma DPP-4 activity�

Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration

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La WG

2014-05-01

Full Text Available Wan-Geun La,1 Min Jin,1 Saibom Park,1,2 Hee-Hun Yoon,1 Gun-Jae Jeong,1 Suk Ho Bhang,1 Hoyoung Park,1,2 Kookheon Char,1,2 Byung-Soo Kim1,31School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea; 2The National Creative Research Initiative Center for Intelligent Hybrids, Seoul National University, Seoul, Republic of Korea; 3Institute of Bioengineering, Institute of Chemical Processes, Engineering Research Institute, Seoul National University, Seoul, Republic of KoreaAbstract: In this study, we demonstrate that graphene oxide (GO can be used for the delivery of bone morphogenetic protein-2 (BMP-2 and substance P (SP, and that this delivery promotes bone formation on titanium (Ti implants that are coated with GO. GO coating on Ti substrate enabled a sustained release of BMP-2. BMP-2 delivery using GO-coated Ti exhibited a higher alkaline phosphatase activity in bone-forming cells in vitro compared with bare Ti. SP, which is known to recruit mesenchymal stem cells (MSCs, was co-delivered using Ti or GO-coated Ti to further promote bone formation. SP induced the migration of MSCs in vitro. The dual delivery of BMP-2 and SP using GO-coated Ti showed the greatest new bone formation on Ti implanted in the mouse calvaria compared with other groups. This approach may be useful to improve osteointegration of Ti in dental or orthopedic implants.Keywords: bone morphogenetic protein-2, bone regeneration, graphene oxides, stem cell recruitment, substance P

Structural modeling of age specific fertility curves in Peninsular Malaysia: An approach of Lee Carter method

Science.gov (United States)

Hanafiah, Hazlenah; Jemain, Abdul Aziz

2013-11-01

In recent years, the study of fertility has been getting a lot of attention among research abroad following fear of deterioration of fertility led by the rapid economy development. Hence, this study examines the feasibility of developing fertility forecasts based on age structure. Lee Carter model (1992) is applied in this study as it is an established and widely used model in analysing demographic aspects. A singular value decomposition approach is incorporated with an ARIMA model to estimate age specific fertility rates in Peninsular Malaysia over the period 1958-2007. Residual plots is used to measure the goodness of fit of the model. Fertility index forecast using random walk drift is then utilised to predict the future age specific fertility. Results indicate that the proposed model provides a relatively good and reasonable data fitting. In addition, there is an apparent and continuous decline in age specific fertility curves in the next 10 years, particularly among mothers' in their early 20's and 40's. The study on the fertility is vital in order to maintain a balance between the population growth and the provision of facilities related resources.

Three-dimensional culture and interaction of cancer cells and dendritic cells in an electrospun nano-submicron hybrid fibrous scaffold

Directory of Open Access Journals (Sweden)

Kim TE

2016-03-01

Full Text Available Tae-Eon Kim,1–3,* Chang Gun Kim,1–3,* Jin Soo Kim,4 Songwan Jin,4 Sik Yoon,5 Hae-Rahn Bae,6 Jeong-Hwa Kim,7,8 Young Hun Jeong,7,8 Jong-Young Kwak1–3 1Department of Pharmacology, School of Medicine, 2Department of Biomedical Sciences, The Graduate School, Ajou University, Suwon, South Korea; 3Immune Network Pioneer Research Center, Ajou University Medical Center, Suwon, South Korea; 4Department of Mechanical Engineering, Korea Polytechnic University, Gyeonggi, South Korea; 5Department of Anatomy, School of Medicine, Pusan National University, Yangsan, South Korea; 6Department of Physiology, College of Medicine, Dong-A University, Busan, South Korea; 7School of Mechanical Engineering, 8Department of Mechanical Engineering, Graduate School, Kyungpook National University, Daegu, South Korea *These authors contributed equally to this work Abstract: An artificial three-dimensional (3D culture system that mimics the tumor microenvironment in vitro is an essential tool for investigating the cross-talk between immune and cancer cells in tumors. In this study, we developed a 3D culture system using an electrospun poly(ε-caprolactone (PCL nanofibrous scaffold (NFS. A hybrid NFS containing an uninterrupted network of nano- and submicron-scale fibers (400 nm to 2 µm was generated by deposition onto a stainless steel mesh instead of an aluminum plate. The hybrid NFS contained multiplanar pores in a 3D structure. Surface-seeded mouse CT26 colon cancer cells and bone marrow-derived dendritic cells (BM-DCs were able to infiltrate the hybrid NFS within several hours. BM-DCs cultured on PCL nanofibers showed a baseline inactive form, and lipopolysaccharide (LPS-activated BM-DCs showed increased expression of CD86 and major histocompatibility complex Class II. Actin and phosphorylated FAK were enriched where unstimulated and LPS-stimulated BM-DCs contacted the fibers in the 3D hybrid NFS. When BM-DCs were cocultured with mitoxantrone-treated CT26 cells in

Economic Growth and Sustainable Housing: An Uneasy Relationship

DEFF Research Database (Denmark)

Buch-Hansen, Hubert

2017-01-01

Book review of: "Economic Growth and Sustainable Housing: An Uneasy Relationship" by Jin Xue (Routledge, 2014)......Book review of: "Economic Growth and Sustainable Housing: An Uneasy Relationship" by Jin Xue (Routledge, 2014)...

Dreams of the Hmong Kingdom: The Quest for Legitimation in French Indochina, 1850- 1960, by Mai Na M. Lee. Madison, University of Wisconsin Press, 2015. 430 pages.

Directory of Open Access Journals (Sweden)

Nengher N. Vang

2015-12-01

Full Text Available This article provides a book review of Mai Na M. Lee’s Dreams of the Hmong Kingdom: The Quest for Legitimation in French Indochina, 1850-1960. Dreams of the Hmong Kingdom. It highlights the contribution of the book to the historiography of the Hmong and provides a critical assessment of the dichotomous analytical framework that Lee uses to analyze the rivalry between Hmong messianic leaders and Hmong political brokers and the competition between the Ly and Lo clans for paramountcy in French Indochina

O Vigia de O Sol é Para Todos: representações do racismo e das relações raciais sulistas na obra de Harper Lee

OpenAIRE

Goulart, Henrique Rodrigues de Paula

2017-01-01

O presente trabalho dedica-se a uma leitura crítica de O Sol é Para Todos, célebre romance publicado em 1960 pela escritora norte-americana Harper Lee e adaptado para o cinema em 1962. A  proposta consiste em compreender as representações históricas produzidas pelas obras – literária e fílmica – acerca dos embates raciais atravessados pelo Sul dos Estados Unidos no contexto do Movimento pelos Direitos Civis. Por último, pretende-se comparar tais representações às de Vá, Coloque um Vigia, vers...

Isolation of reovirus T3D mutants capable of infecting human tumor cells independent of junction adhesion molecule-A.

Directory of Open Access Journals (Sweden)

Diana J M van den Wollenberg

Full Text Available Mammalian Reovirus is a double-stranded RNA virus with a distinctive preference to replicate in and lyse transformed cells. On that account, Reovirus type 3 Dearing (T3D is clinically evaluated as oncolytic agent. The therapeutic efficacy of this approach depends in part on the accessibility of the reovirus receptor Junction Adhesion Molecule-A (JAM-A on the target cells. Here, we describe the isolation and characterization of reovirus T3D mutants that can infect human tumor cells independent of JAM-A. The JAM-A-independent (jin mutants were isolated on human U118MG glioblastoma cells, which do not express JAM-A. All jin mutants harbour mutations in the S1 segments close to the region that encodes the sialic acid-binding pocket in the shaft of the spike protein. In addition, two of the jin mutants encode spike proteins with a Q336R substitution in their head domain. The jin mutants can productively infect a wide range of cell lines that resist wt reovirus T3D infection, including chicken LMH cells, hamster CHO cells, murine endothelioma cells, human U2OS and STA-ET2.1 cells, but not primary human fibroblasts. The jin-mutants rely on the presence of sialic-acid residues on the cell surface for productive infection, as is evident from wheat germ agglutinin (WGA inhibition experiments, and from the jin-reovirus resistance of CHO-Lec2 cells, which have a deficiency of sialic-acids on their glycoproteins. The jin mutants may be useful as oncolytic agents for use in tumors in which JAM-A is absent or inaccessible.

Improvement in the amine glass platform by bubbling method for a DNA microarray

Directory of Open Access Journals (Sweden)

Jee SH

2015-10-01

Full Text Available Seung Hyun Jee,1 Jong Won Kim,2 Ji Hyeong Lee,2 Young Soo Yoon11Department of Chemical and Biological Engineering, Gachon University, Seongnam, Gyeonggi, Republic of Korea; 2Genomics Clinical Research Institute, LabGenomics Co., Ltd., Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of KoreaAbstract: A glass platform with high sensitivity for sexually transmitted diseases microarray is described here. An amino-silane-based self-assembled monolayer was coated on the surface of a glass platform using a novel bubbling method. The optimized surface of the glass platform had highly uniform surface modifications using this method, as well as improved hybridization properties with capture probes in the DNA microarray. On the basis of these results, the improved glass platform serves as a highly reliable and optimal material for the DNA microarray. Moreover, in this study, we demonstrated that our glass platform, manufactured by utilizing the bubbling method, had higher uniformity, shorter processing time, lower background signal, and higher spot signal than the platforms manufactured by the general dipping method. The DNA microarray manufactured with a glass platform prepared using bubbling method can be used as a clinical diagnostic tool. Keywords: DNA microarray, glass platform, bubbling method, self-assambled monolayer

Social networks and inference about unknown events: A case of the match between Google's AlphaGo and Sedol Lee.

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Jonghoon Bae

Full Text Available This study examines whether the way that a person makes inferences about unknown events is associated with his or her social relations, more precisely, those characterized by ego network density that reflects the structure of a person's immediate social relation. From the analysis of individual predictions over the Go match between AlphaGo and Sedol Lee in March 2016 in Seoul, Korea, this study shows that the low-density group scored higher than the high-density group in the accuracy of the prediction over a future state of a social event, i.e., the outcome of the first game. We corroborated this finding with three replication tests that asked the participants to predict the following: film awards, President Park's impeachment in Korea, and the counterfactual assessment of the US presidential election. Taken together, this study suggests that network density is negatively associated with vision advantage, i.e., the ability to discover and forecast an unknown aspect of a social event.

Demixing and nematic behaviour of oblate hard spherocylinders and hard spheres mixtures: Monte Carlo simulation and Parsons-Lee theory

Science.gov (United States)

Gámez, Francisco; Acemel, Rafael D.; Cuetos, Alejandro

2013-10-01

Parsons-Lee approach is formulated for the isotropic-nematic transition in a binary mixture of oblate hard spherocylinders and hard spheres. Results for the phase coexistence and for the equation of state in both phases for fluids with different relative size and composition ranges are presented. The predicted behaviour is in agreement with Monte Carlo simulations in a qualitative fashion. The study serves to provide a rational view of how to control key aspects of the behaviour of these binary nematogenic colloidal systems. This behaviour can be tuned with an appropriate choice of the relative size and molar fractions of the depleting particles. In general, the mixture of discotic and spherical particles is stable against demixing up to very high packing fractions. We explore in detail the narrow geometrical range where demixing is predicted to be possible in the isotropic phase. The influence of molecular crowding effects on the stability of the mixture when spherical molecules are added to a system of discotic colloids is also studied.

The Impacts of Different PBL Schemes on the Simulation of PM2.5 during Severe Haze Episodes in the Jing-Jin-Ji Region and Its Surroundings in China

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Tian Li

2016-01-01

Full Text Available In this study, three schemes [Yonsei University (YSU, Mellor-Yamada-Janjic (MYJ, and Bougeault-Lacarrère (Boulac] were employed in the Weather Research and Forecasting/Chemistry (WRF-Chem model to simulate the severe haze that occurred in February 2014 in the Jing-Jin-Ji region and its surroundings. The PM2.5 concentration simulated using the three schemes, together with the meteorological factors closely related to PM2.5 (wind speed, local vertical diffusivity, and PBL height, was evaluated through comparison with observations. The results indicated that the eastern plain cities produced better simulation results than the western cities, and the cities under the eastern root of Taihang Mountain produced the worst results in simulating high PM2.5 concentration in haze. All three schemes simulated very similar variation trends of the surface PM2.5 concentration compared with observations. The diurnal variations of simulated surface PM2.5 were not as reasonable as their reflection of daily averaged variation. The simulated concentrations of surface PM2.5 using the YSU, MYJ, and Boulac schemes all showed large negative errors during daytime in polluted days due to their inefficient descriptions of local atmospheric stability or diffusion processes in haze. The lower ability of PBL schemes in distinguishing the diffusion between haze and clean days in the complex topography areas in China is an important problem for PM2.5 forecasting, which is worthy of being studied in detail.

JPRS Report, China, Maos Legacy in Anhui, Rural Reform 1978-80.

Science.gov (United States)

1989-07-28

boil some noodles , and then asked Zhan Shaozhou: "What brought you here?" "To report to you!" "Report what?" "It has begun. More is being done...policy of looking after serious disaster areas on holidays, providing each person with 3 jin of rice, 2 jin of noodles , and xh jin of meat. They went...abandon for an instant ! Chapter 6. A Tragedy Not To Be Repeated—1980: The Great Anhui Flood History Continues To Testify 1 The Earth, which nurtures us

Určení hodnoty věcných břemen stavby na cizím pozemku a přechodu nebo přejezdu přes pozemek jiného vlastníka

OpenAIRE

Kuhrová, Kristýna

2011-01-01

Diplomová práce je zaměřena na problematiku věcných břemen z hlediska činnosti znalce. V první části práce je proveden rozbor platné právní úpravy věcných břemen, jejich členění, příčiny možného vzniku, změn a zániku. Dále následuje obecný popis metodiky oceňování věcných břemen, vymezení jednotlivých druhů cen a účelů oceňování věcných břemen. V návrhové části je teoretický rozbor aplikován na dva konkrétní případy věcných břemen, a to věcného břemene přechodu přes pozemek jiného vlastníka a...

Passacaglia van J.S. Bach en Das Passagen-Werk van Walter Benjamin - literêre montage as mosaïekwerk in Memorandum. 'n Verhaal met skilderye (2006)

OpenAIRE

van Vuuren, Helize

2014-01-01

Van Niekerk se Memorandum-narratief is 'n gedenkskrif vir die elegies-realistiese skilder, Adriaan van Zyl, wat in September 2006 sterf - soos Walter Benjamin in sy laat veertigs en insgelyks met sy kunstenaarsloopbaan onderbreek. Van Niekerk stel in Memorandum vir haarself 'n uitdagende taak (soos Wiid dit formuleer aan die begin van "Memorandum 3"): om Bach se Passacaglia en fuga in C Mineur (BWV 582) (± 1715) te "vertaal" in prosa en om 'n kleiner, Afrikaanse weergawe van Benjamin se Das P...

The Effect of Selected Cleaning Techniques on Berkshire Lee Marble: A Scientific Study at Philadelphia City Hall

Science.gov (United States)

Mossotti, Victor G.; Eldeeb, A. Raouf; Fries, Terry L.; Coombs, Mary Jane; Naude, Virginia N.; Soderberg, Lisa; Wheeler, George S.

2002-01-01

This report describes a scientific investigation of the effects of eight different cleaning techniques on the Berkshire Lee marble component of the facade of the East Center Pavilion at Philadelphia City Hall; the study was commissioned by the city of Philadelphia. The eight cleaning techniques evaluated in this study were power wash (proprietary gel detergent followed by water rinse under pressure), misting (treatment with potable, nebulized water for 24-36 hours), gommage (proprietary Thomann-Hanry low-pressure, air-driven, small-particle, dry abrasion), combination (gommage followed by misting), Armax (sodium bicarbonate delivered under pressure in a water wash), JOS (dolomite powder delivered in a low-pressure, rotary-vortex water wash), laser (thermal ablation), and dry ice (powdered-dry-ice abrasion delivered under pressure). In our study approximately 160 cores were removed from the building for laboratory analysis. We developed a computer program to analyze scanning-electron-micrograph images for the microscale surface roughness and other morphologic parameters of the stone surface, including the near-surface fracture density of the stone. An analysis of more than 1,100 samples cut from the cores provided a statistical basis for crafting the essential elements of a reduced-form, mixed-kinetics conceptual model that represents the deterioration of calcareous stone in terms of self-organized soiling and erosion patterns. This model, in turn, provided a basis for identifying the variables that are affected by the cleaning techniques and for evaluating the extent to which such variables influence the stability of the stone. The model recognizes three classes of variables that may influence the soiling load on the stone, including such exogenous environmental variables as airborne moisture, pollutant concentrations, and local aerodynamics, and such endogenous stone variables as surface chemistry and microstructure (fracturing, roughness, and so on). This study

Social networks and inference about unknown events: A case of the match between Google’s AlphaGo and Sedol Lee

Science.gov (United States)

Bae, Jonghoon; Cha, Young-Jae; Lee, Hyungsuk; Lee, Boyun; Baek, Sojung; Choi, Semin

2017-01-01

This study examines whether the way that a person makes inferences about unknown events is associated with his or her social relations, more precisely, those characterized by ego network density that reflects the structure of a person’s immediate social relation. From the analysis of individual predictions over the Go match between AlphaGo and Sedol Lee in March 2016 in Seoul, Korea, this study shows that the low-density group scored higher than the high-density group in the accuracy of the prediction over a future state of a social event, i.e., the outcome of the first game. We corroborated this finding with three replication tests that asked the participants to predict the following: film awards, President Park’s impeachment in Korea, and the counterfactual assessment of the US presidential election. Taken together, this study suggests that network density is negatively associated with vision advantage, i.e., the ability to discover and forecast an unknown aspect of a social event. PMID:28222114

Kuues "Diverse. Universe" / Sandra Jõgeva

Index Scriptorium Estoniae

Jõgeva, Sandra, 1976-

2010-01-01

Non Grata korraldatud rahvusvaheline performance'i-kunsti festival "Diverse Universe 2010" Pärnu Kunstihallis ja Pärnu Kunstnike Majas 23. ja 24. aprillil. Rühmituste Juurikasvu (Soome), Cnopt (Eesti), Rubensid (Eesti), Ornicart (Prantsusmaa), Zane Matule ja Gatis Vectirānsi (Läti) jt. performance'itest

1409-IJBCS-Article-Sandra Farias+

African Journals Online (AJOL)

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reduction, promoting greater social contact, and represent a ... Uberlândia-Brazil (CEP/UFU), receiving the .... Table 4: Profile of research subjects. .... Improvement of Higher Education Personnel ... Biominerals Company and to the teacher.

Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy

Directory of Open Access Journals (Sweden)

Oh KS

2016-03-01

Full Text Available Keun Sang Oh,1,* Kyungim Kim,1,* Byeong Deok Yoon,1 Hye Jin Lee,1 Dal Yong Park,1 Eun-yeong Kim,1 Kiho Lee,1 Jae Hong Seo,2 Soon Hong Yuk1,2 1College of Pharmacy, Korea University, Sejong, 2Biomedical Research Center, Korea University Guro Hospital, Guro-gu, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: A mixture of docetaxel (DTX and Solutol® HS 15 (Solutol transiently formed nanodroplets when it was suspended in an aqueous medium. However, nanodroplets that comprised DTX and Solutol showed a rapid precipitation of DTX because of their unstable characteristics in the aqueous medium. The incorporation of nanodroplets that comprised DTX and Solutol through vesicle fusion and subsequent stabilization was designed to prepare multilayer nanoparticles (NPs with a DTX-loaded Solutol nanodroplet (as template NPs core for an efficient delivery of DTX as a chemotherapeutic drug. As a result, the DTX-loaded Solutol nanodroplets (~11.7 nm were observed to have an increased average diameter (from 11.7 nm to 156.1 nm and a good stability of the hydrated NPs without precipitation of DTX by vesicle fusion and multilayered structure, respectively. Also, a long circulation of the multilayer NPs was observed, and this was due to the presence of Pluronic F-68 on the surface of the multilayer NPs. This led to an improved antitumor efficacy based on the enhanced permeation and retention effect. Therefore, this study indicated that the multilayer NPs have a considerable potential as a drug delivery system with an enhanced therapeutic efficacy by blood circulation and with low side effects. Keywords: multilayer nanoparticles, Solutol, Pluronic F-68, docetaxel, cancer therapy

Chronic depression treated successfully with novel taping therapy: a new approach to the treatment of depression

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Han CH

2016-06-01

Full Text Available Chang Hyun Han,1,* Hwa Soo Hwang,2,* Young Joon Lee,3 Sang Nam Lee,4 Jane J Abanes,5 Bong Hyo Lee6 1Clinical Research Division, Korea Institute of Oriental Medicine, Daejeon, 2Chims-Saengvit Oriental Medicine Clinic, Seoul, 3Department of Preventive Korean Medicine, 4Department of Qigong, College of Korean Medicine, Daegu Haany University, Gyeongsangbuk-do, South Korea; 5Daniel K Inouye Graduate School of Nursing, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; 6Department of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, Daegu, South Korea *These authors contributed equally to this work Introduction: Despite improved research in the treatment, depression remains difficult to treat. Till date, successful treatment of depression using taping therapy has not been known yet. We report cases where patients with severe depressive symptoms were successfully treated by taping therapy, a new approach.Methods: In case 1, a patient was taking several psychiatric medications for 10 years and admitted often to the psychiatric hospital with a leaning head, flexible legs, and nearly closed eyes; in case 2, a patient after a hysterectomy complained with heart palpitations, depressive- and anxiety-like behaviors, insomnia, and gastrointestinal problems; and in case 3, a patient with complaints of adverse effects from antidepressant medications had suicidal thoughts frequently. The medical tapes were placed on acupoints, trigger points, and pain points found by finger pressing examination in the chest, sides, and upper back of the patients.Results: In case 1, the patient started weeping immediately after the first treatment. He discontinued psychiatric drugs and returned to baseline functioning after 2 months. In case 2, the patient felt at ease showing decreased palpitation immediately after the first treatment, and after 1 week, she quit medications. In case 3, the patient experienced a

Produktiwiteit en verantwoordelikheid, enkele sielkundige aspekte

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A. P. Venter

1978-11-01

Maslow se motiveringsteorie wat uit die kliniese sielkunde ontspruit het, is ook deur bedryfsielkundiges van nader beskou, veral in hoe verre dit met produktiwiteit verband het. Enkele sielkundige aspekte word bespreek ten einde op die nut van hierdie teorie in die bedryfsituasie te wys. Die vermoede bestaan dat die teorie deur bedryfsielkundiges nie altyd korrek vertolk word soos Maslow dit self uiteensit nie; veral word die verantwoordelikheidsaspek in die selfuitlewingsbehoeftes misken en nie verreken nie; 'n Logiese konklusie is dat selfuitlewing, soos deur Maslow beskryf, wel verband met produktiwiteit het.

A multivariate assessment of the coral ecosystem health of two embayments on the lee of the island of Hawai'i

Energy Technology Data Exchange (ETDEWEB)

Parsons, Michael L. [Marine Science Department, University of Hawai' i at Hilo, Hilo, HI 96720 (United States)], E-mail: mparsons@fgcu.edu; Walsh, William J. [Division of Aquatic Resources, Department of Land and Natural Resources, Kailua-Kona, HI 96740 (United States); Settlemier, Chelsie J.; White, Darla J.; Ballauer, Josh M.; Ayotte, Paula M.; Osada, Kara M. [Marine Science Department, University of Hawai' i at Hilo, Hilo, HI 96720 (United States); Carman, Brent [Division of Aquatic Resources, Department of Land and Natural Resources, Kailua-Kona, HI 96740 (United States)

2008-06-15

Four coral-dominated coastal sites within two embayments (Kealakekua Bay and Honokohau Bay) on the lee of the island of Hawai'i were studied to assess evidence of anthropogenic impacts in these relatively pristine locales. Nutrient-loading parameters were analyzed in relation to benthic composition data. Statistically, there were significant positive relationships between nitrate + nitrite, silicate, and ammonium with the abundance of macroalgae, coralline algae, and dead coral, and between {delta}{sup 15}N and dead coral abundance. The north outside site of Kealakekua Bay and the south outside site of Honokohau Bay appear to be most impacted by nutrient-loading factors in each bay, respectively. Comparisons with past nutrient data indicate that nutrient inputs have increased to the two bays, and that early impacts of these increased loadings are evident. It is predicted that at current nutrient-loading rates, the north sites of Kealakekua Bay and the south sites of Honokohau Bay will exhibit evidence of further degradation in future years.

Lung function decline rates according to GOLD group in patients with chronic obstructive pulmonary disease

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Kim J

2015-09-01

Full Text Available Joohae Kim,1 Ho Il Yoon,2 Yeon-Mok Oh,3 Seong Yong Lim,4 Ji-Hyun Lee,5 Tae-Hyung Kim,6 Sang Yeub Lee,7 Jin Hwa Lee,8 Sang-Do Lee,3 Chang-Hoon Lee11Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, 3Department of Pulmonary and Critical Care Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, 4Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 5Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, 6Division of Pulmonology, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, 7Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Korea University, 8Department of Internal Medicine, Ewha Womans University Mokdong Hospital, College of Medicine, Ewha Womans University, Seoul, Republic of KoreaBackground: Since the Global Initiative for Chronic Obstructive Lung Disease (GOLD groups A-D were introduced, the lung function changes according to group have been evaluated rarely.Objective: We investigated the rate of decline in annual lung function in patients categorized according to the 2014 GOLD guidelines.Methods: Patients with COPD included in the Korean Obstructive Lung Disease (KOLD prospective study, who underwent yearly postbronchodilator spirometry at least three times, were included. The main outcome was the annual decline in postbronchodilator forced expiratory volume in 1 second (FEV1, which was analyzed by

Measuring Cooperative Biological Engagement Program (CBEP) Performance: Capacities, Capabilities, and Sustainability Enablers for Biorisk Management and Biosurveillance

Science.gov (United States)

2014-01-01

Monica, Calif.: RAND Corporation, MG-662-OSD, 2008. As of May 21, 2014: http://www.rand.org/pubs/monographs/MG662.html de Sa, Joia , Sandra Mounier...Hanvoravongchai, Piya, Wiku Adisasmito, Pham Ngoc Chau, Alexandra Conseil, Joia de Sa, Ralf Krumkamp, Sandra Mounier-Jack, Bounlay Phommasack...This work should be of interest to CBEP and CTR leadership as they seek to improve program design , budget allocation, and execution and to

Clinical Feasibility of Continuously Monitored Data for Heart Rate, Physical Activity, and Sleeping by Wearable Activity Trackers in Patients with Thyrotoxicosis: Protocol for a Prospective Longitudinal Observational Study.

Science.gov (United States)

Lee, Jie-Eun; Lee, Dong Hwa; Oh, Tae Jung; Kim, Kyoung Min; Choi, Sung Hee; Lim, Soo; Park, Young Joo; Park, Do Joon; Jang, Hak Chul; Moon, Jae Hoon

2018-02-21

Thyrotoxicosis is a common disease caused by an excess of thyroid hormones. The prevalence of thyrotoxicosis about 2% and 70-90% of thyrotoxicosis cases are caused by Graves' disease, an autoimmune disease, which has a high recurrence rate when treated with antithyroid drugs such as methimazole or propylthiouracil. The clinical symptoms and signs of thyrotoxicosis include palpitation, weight loss, restlessness, and difficulty sleeping. Although these clinical changes in thyrotoxicosis can be detected by currently available wearable activity trackers, there have been few trials of the clinical application of wearable devices in patients with thyrotoxicosis. The aim of this study is to investigate the clinical applicability of wearable device-generated data to the management of thyrotoxicosis. We are analyzing continuously monitored data for heart rate, physical activity, and sleep in patients with thyrotoxicosis during their clinical course after treatment. Thirty thyrotoxic patients and 10 control subjects were enrolled in this study at Seoul National University Bundang Hospital. Heart rate, physical activity, and sleep are being monitored using a Fitbit Charge HR or Fitbit Charge 2. Clinical data including anthropometric measures, thyroid function test, and hyperthyroidism symptom scale are recorded. Study enrollment began in December 2016, and the intervention and follow-up phases are ongoing. The results of the data analysis are expected to be available by September 2017. This study will provide a foundational feasibility trial of the clinical applications of biosignal measurements to the differential diagnosis, prediction of clinical course, early detection of recurrence, and treatment in patients with thyrotoxicosis. ClinicalTrials.gov NCT03009357; https://clinicaltrials.gov/ct2/show/NCT03009357 (Archived by WebCite at http://www.webcitation.org/6wh4MWPm2). ©Jie-Eun Lee, Dong Hwa Lee, Tae Jung Oh, Kyoung Min Kim, Sung Hee Choi, Soo Lim, Young Joo Park, Do

Embodied Rhythm: Commentary on "The Contribution of Anthropometric Factors to Individual Differences in the Perception of Rhythm" by Neil P. McAngus Todd, Rosanna Cousins, and Christopher S. Lee

Directory of Open Access Journals (Sweden)

Bruno H. Repp

2007-01-01

Full Text Available Todd, Cousins, and Lee (2007 have presented some intriguing data suggesting that body size, as measured by standard anthropometric indices, is related to the preferred beat period in a perceptual task. Curiously, however, they did not find a significant sex difference, even though the women in their sample were clearly smaller than the men. Another recent study of preferred spontaneous tempo (McAuley et al., 2006 likewise failed to find a sex difference in a large sample of young adults. It is unclear why body size should have an effect only within each sex group.

The Militia of Jin-Cha-Ji Border Area in the Anti-Japanese War Period%抗战时期晋察冀边区的民兵

Institute of Scientific and Technical Information of China (English)

栾盈菊

2013-01-01

晋察冀民兵是在共产党的动员和领导下建立和壮大起来的不脱离生产的群众武装。民兵的任务是进行游击战、配合部队作战和担任抗战勤务。民兵的军事战术有麻雀战、地雷战、地道战、扭击战和伏击战等。在民兵队伍中，由于有党的政治动员、党员的带头作用、有组织的军事政治教育和组织的民主性等原因，民兵成为打败日寇的重要力量，同时民兵也是主力军与游击队的助手，是主力军的重要兵源。%The militia of Jin-Cha-Ji border area was the armed masses without departing from the pro-duction,which was established and grew under the leadership of the Party.Its mission was to carry outguerrilla warfare,cooperate with the troops and act as war service.It had many tactics,such as sparrowwarfare,mine warfare,tunnel warfare,torsional warfare and ambush operation.Due to the Party’s politi-cal mobilization and the Party members’leading role,with organized military and political education anddemocratic nature of the organization,the militia was not only an important force to beat the Japanese,butalso assistant of the main force and the guerrillas,and the important sources for the recruits of the mainforce troops.

X-ray Radiation Mechanisms and the Beaming Effect of Hot Spots ...

Indian Academy of Sciences (India)

Astr. (2011) 32, 193–196 c Indian Academy of Sciences. X-ray Radiation Mechanisms and the Beaming Effect of Hot Spots and Knots in AGN Jets. Jin Zhang1,∗. , Jin-Ming Bai2, Liang Chen2 & Enwei Liang3. 1College of Physics and Electronic Engineering, Guangxi Teachers Education University,. Nanning 530001, China.

PREFACE: International Conference on Inverse Problems 2010

Science.gov (United States)

Hon, Yiu-Chung; Ling, Leevan

2011-03-01

Following the first International Conference on Inverse Problems - Recent Theoretical Development and Numerical Approaches held at the City University of Hong Kong in 2002, the fifth International Conference was held again at the City University during December 13-17, 2010. This fifth conference was jointly organized by Professor Yiu-Chung Hon (Co-Chair, City University of Hong Kong, HKSAR), Dr Leevan Ling (Co-Chair, Hong Kong Baptist University, HKSAR), Professor Jin Cheng (Fudan University, China), Professor June-Yub Lee (Ewha Womans University, South Korea), Professor Gui-Rong Liu (University of Cincinnati, USA), Professor Jenn-Nan Wang (National Taiwan University, Taiwan), and Professor Masahiro Yamamoto (The University of Tokyo, Japan). It was agreed to alternate holding the conference among the above places (China, Japan, Korea, Taiwan, and Hong Kong) once every two years. The next conference has been scheduled to be held at the Southeast University (Nanjing, China) in 2012. The purpose of this series of conferences is to establish a strong collaborative link among the universities of the Asian-Pacific regions and worldwide leading researchers in inverse problems. The conference addressed both theoretical (mathematics), applied (engineering) and developmental aspects of inverse problems. The conference was intended to nurture Asian-American-European collaborations in the evolving interdisciplinary areas and it was envisioned that the conference would lead to long-term commitments and collaborations among the participating countries and researchers. There was a total of more than 100 participants. A call for the submission of papers was sent out after the conference, and a total of 19 papers were finally accepted for publication in this proceedings. The papers included in the proceedings cover a wide scope, which reflects the current flourishing theoretical and numerical research into inverse problems. Finally, as the co-chairs of the Inverse Problems

China's 'recycling economy'

DEFF Research Database (Denmark)

Mehlsen, Camilla

2009-01-01

Climate change and sustainability are hot topics in China, but it is hard to find research addressing the outcomes of Education for Sustainable Development, says Associate Professor Yi Jin.......Climate change and sustainability are hot topics in China, but it is hard to find research addressing the outcomes of Education for Sustainable Development, says Associate Professor Yi Jin....

Cyber Practices: What Can the U.S. Air Force Learn from the Commercial Sector?

Science.gov (United States)

2015-01-01

dam/lockheed/data/isgs/documents/LMCSA%20Ov erview%20Fact%20Sheet_Final%20%282%29. pdf Lunt, Barry, Joseph J. Ekstrom, Sandra Gorka, Gregory Hislop ...Electronics Engineers, 2006, p. 33. 21 Barry Lunt, Joseph J. Ekstrom, Sandra Gorka, Gregory Hislop , Reza Kamali, Eydie Lawson, Richard LeBlanc, Jacob Miller...1 (January 1980 ). 106 Daft, 2008, p. 17. 107 Gerald D. Bell, “Determinants of Span of Control,” American Journal of Sociology 73, no. 1 (1967

Reorientando a identidade nacional em Native speaker, de Chang-rae Lee, e O sol se põe em São Paulo, de Bernardo Carvalho

Directory of Open Access Journals (Sweden)

Rex P. Nielson

2014-01-01

Full Text Available A comparative reading of the novels Native speaker (1995, by the North American writer Chang-rae Lee, and O sol se põe em São Paulo (2007, by Bernardo Carvalho, allows for a reevaluation of how minority identities have been constructed in the two American megalopolises New York and São Paulo. The plotlines of both nove ls hinge on the identity crisis of a second-generation Asian immigrant (from Korea in one case and Japan in the other who is seeking to negotiate his American identity (speaking in hemispheric terms in terms of his family‟s origin and language. However, despite the similar anxieties over assimilation present in both novels, they both reveal significant differences regarding the ways in which the United States and Brazil have responded to cultural difference even as they challenge national myths of inclusi on and belonging.

Una mirada crítico-hermenéutica a las representaciones sociales de la infancia a través de las imágenes plasmadas en la cartilla inicial de lectura Nacho lee: 1974-2011

OpenAIRE

Álvarez Torres, Jair Hernando; Naranjo Loaiza, Jenyffer

2013-01-01

This article approaches, from a critical-hermeneutical view, the role played by the teaching manual in the childhood scholarity and its influence on the representations and the imaginaries of children in Colombia between 1974 and 2011. In order to do so, the text for reading initiation Nacho lee was chosen because it is a manual that still exists in the mind and in the imaginaries of Colombians and also is a text that is easy to get in the market, a condition n...

International Space Station Systems Engineering. Case Study

Science.gov (United States)

2010-01-01

negotiators to move beyond an impasse.108  Don’t be so ready to chase revolutionary designs over evolutionary designs. A key lesson from Russian...112 2002 Oct. 7 2002 Oct. 18 9A S1 truss delivery Jeffrey S. Ashby, Pamela A. Melroy, David A. Wolf, Piers J. Sellers, Sandra H. Magnus , Fyodor...2002 Oct. 18 9A S1 truss delivery Jeffrey S. Ashby, Pamela A. Melroy, David A. Wolf, Piers J. Sellers, Sandra H. Magnus , Fyodor N. Yurchikhin

Enhanced oral bioavailability of valsartan using a polymer-based supersaturable self-microemulsifying drug delivery system

Directory of Open Access Journals (Sweden)

Yeom DW

2017-05-01

Full Text Available Dong Woo Yeom,1,* Bo Ram Chae,2,* Ho Yong Son,1 Jin Han Kim,1 Jun Soo Chae,1 Seh Hyon Song,2 Dongho Oh,2 Young Wook Choi1 1College of Pharmacy, Chung-Ang University, Seoul, 2Daewon Pharm. Co., Ltd, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: A novel, supersaturable self-microemulsifying drug delivery system (S-SMEDDS was successfully formulated to enhance the dissolution and oral absorption of valsartan (VST, a poorly water-soluble drug, while reducing the total quantity for administration. Poloxamer 407 is a selectable, supersaturating agent for VST-containing SMEDDS composed of 10% Capmul® MCM, 45% Tween® 20, and 45% Transcutol® P. The amounts of SMEDDS and Poloxamer 407 were chosen as formulation variables for a 3-level factorial design. Further optimization was established by weighting different levels of importance on response variables for dissolution and total quantity, resulting in an optimal S-SMEDDS in large quantity (S-SMEDDS_LQ; 352 mg in total and S-SMEDDS in reduced quantity (S-SMEDDS_RQ; 144.6 mg in total. Good agreement was observed between predicted and experimental values for response variables. Consequently, compared with VST powder or suspension and SMEDDS, both S-SMEDDS_LQ and S-SMEDDS_RQ showed excellent in vitro dissolution and in vivo oral bioavailability in rats. The magnitude of dissolution and absorption-enhancing capacities using quantity-based comparisons was in the order S-SMEDDS_RQ > S-SMEDDS_LQ > SMEDDS > VST powder or suspension. Thus, we concluded that, in terms of developing an effective SMEDDS preparation with minimal total quantity, S-SMEDDS_RQ is a promising candidate. Keywords: valsartan, SMEDDS, supersaturation, factorial design, optimization, bio­availability 

Nooremas keskeas klassikute nukuteater / Sandra Jõgeva

Index Scriptorium Estoniae

Jõgeva, Sandra, 1976-

2010-01-01

Silja Saarepuu ja Villu Plingi näitus "Aknal" Pärnu Kunstihallis 28. veebruarini 2010. Suure osa eksponeeritud loomingust hõlmab nn väikeste inimeste teema. Jasper Zoova ruumiliste maalide näitus "Jass tuli koju" Jazz Cafés Pärnus 3. märtsini 2010

Mitmekülgne universum / Sandra Jõgeva

Index Scriptorium Estoniae

Jõgeva, Sandra, 1976-

2008-01-01

26. V toimunud tegevuskunstifestivali "Diverse Universe 2008" performance''i-konverentsist Pärnus Academia Non Grata majas. Tutvustati kollektiive HorseCow (California, Sacramento), GoGoTrash (Kesselberg), Berliini kunstnikerühmitust Open Space, 500 korea performance'i-kunstnikku koondavat isetekkelist organisatsiooni KOPAS - Korea Performance Art Spirit, ettekandega esines Brightoni kunstnik Orion Maxted

Smells Like Teen Spirit / Sandra Jõgeva

Index Scriptorium Estoniae

Jõgeva, Sandra, 1976-

2009-01-01

Kuigi on majanduslik langus, tekib praegu juurde loomelinnakuid ja kultuuriruume (Rotermanni loovala, Baltika loomeinkubaator, Telliskivi loomelinnak jne.). Riia kesklinnas olid septembris projekti Survival Kit raames avatud ajutised kunstigaleriid südalinna äripindadel. Autori sõnul on õhus üheksakümnendate hõngu, vanad jõuvahekorrad enam ei kehti, tekib uusi võimalusi

Paraproletariaat ja vilets Valgre / Sandra Jõgeva

Index Scriptorium Estoniae

Jõgeva, Sandra, 1976-

2008-01-01

Eesti Kunstiakadeemia interdistsiplinaarsete kunstide osakonna ning Pärnu filmi- ja videofestivali alternatiivkino "Le Cinema Extraordinaire" (kuraatorid Erik Alalooga ja Ville-Karel Viirelaid) Tallinnas Nongrata Kunstikonteineris kultuuritehases Polymer 1.-22. II. Minna Hindi autoriõhtu (filmid "Kolm pilti elust ja ajast" ning "Sees või väljas") ja Jaan-Jürgen Klausi filmid "Sinitäheke" (peategelane Erkki Hüva) ning "Erakpoeet Marko Kompus"

Level II scour analysis for Bridge 38 (JERITH0020038) on Town Highway 20, crossing the Lee River, Jericho, Vermont

Science.gov (United States)

Wild, Emily C.; Degnan, James R.

1997-01-01

This report provides the results of a detailed Level II analysis of scour potential at structure JERITH00200038 on Town Highway 20 crossing the Lee River, Jericho, Vermont (figures 1–8). A Level II study is a basic engineering analysis of the site, including a quantitative analysis of stream stability and scour (U.S. Department of Transportation, 1993). Results of a Level I scour investigation also are included in Appendix E of this report. A Level I investigation provides a qualitative geomorphic characterization of the study site. Information on the bridge, obtained from Vermont Agency of Transportation (VTAOT) files, was compiled prior to conducting Level I and Level II analyses and is found in Appendix D. The site is in the Green Mountain section of the New England physiographic province and the Champlain section of the St. Lawrence physiographic province in northwestern Vermont. The 12.9-mi2 drainage area is in a predominantly rural and forested basin. In the vicinity of the study site, the surface cover on the upstream and downstream right overbank is pasture while the immediate banks have dense woody vegetation. The surface cover on the upstream and downstream left overbank is forested. In the study area, the Lee River has an incised, sinuous channel with a slope of approximately 0.02 ft/ft, an average channel top width of 89 ft and an average bank height of 14 ft. The channel bed material ranges from sand to boulder with a median grain size (D50) of 45.9 mm (0.151 ft). The geomorphic assessment at the time of the Level I and Level II site visit on July 2, 1996, indicated that the reach was stable. The Town Highway 20 crossing of the Lee River is a 49-ft-long, one-lane bridge consisting of a steel through truss span (Vermont Agency of Transportation, written communication, December 12, 1995). The opening length of the structure parallel to the bridge face is 44 ft. The bridge is supported by vertical, concrete abutments with wingwalls. The channel is

Joint Institute for Nanoscience Annual Report 2003

Energy Technology Data Exchange (ETDEWEB)

Baer, Donald R.; Campbell, Charles

2004-02-01

The Joint Institute for Nanoscience (JIN) is a cooperative venture of the University of Washington and Pacific Northwest National Laboratory to encourage and enhance high-impact and high-quality nanoscience and nanotechnology of all types. This first annual report for the JIN summarizes activities beginning in 2001 and ending at the close of fiscal year 2003 and therefore represents somewhat less than two years of activities. Major portions of the JIN resources are dedicated to funding graduate students and postdoctoral research associates to perform research in collaborations jointly directed by Pacific Northwest National Laboratory (PNNL) staff scientists and University of Washington (UW) professors. These fellowships were awarded on the basis of applications that included research proposals. JIN co-sponsors an annual Nanoscale Science and Technology Workshop held in Seattle. In addition to involving PNNL staff in various UW nanoscience courses and seminars, a National Science Foundation grant Development of UW-PNL Collaborative Curriculums in Nano-Science and Technology has allowed the development of three intensive short courses that are taught by UW faculty, PNNL staff, and faculty from other institutions, including Washington State University, the University of Idaho, Stanford University, and the University of Alaska. The initial JIN agreement recognized that expansion of cooperation beyond UW and PNNL would be highly valuable. Starting in early 2003, efforts were initiated to form a regional communication link called the Northwest Nanoscience and Nanotechnology Network (N₄). In concept, N₄ is a tool to encourage communication and help identify regional resources and nanoscience and technology activities.

Retraction RETRACTION of "Methylation of the RASSFIA promoter in breast cancer" by Y. Ji, H.H. Jin, M.D. Wang, W.X. Cao, J.L. Bao - Genet. Mol. Res. 15 (2): gmr.15028261 (2016) - DOI: 10.4238/gmr.15028261.

Science.gov (United States)

Ji, Y; Jin, H H; Wang, M D; Cao, W X; Bao, J L

2016-10-07

The retracted article is: Ji Y, Jin HH, Wang MD, Cao WX, et al. (2016). Methylation of the RASSFIA promoter in breast cancer. Genet. Mol. Res. 15: gmr.15028261. There are significant parts of this article (particularly, in the discussion section) that are copied from "Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome", by Jia Xu, Priya B Shetty, Weiwei Feng, Carol Chenault, Robert C Bast Jr, Jean-Pierre J Issa, Susan G Hilsenbeck and Yinhua Yu, published in BMC Cancer 2012; 12: 243. DOI: 10.1186/1471-2407-12-243. The first paragraphs of both discussions are identical. This is concerning. The abstract and introduction sections have much of their text plagiarized. Overall, there is high plagiarism detected. The GMR editorial staff was alerted and after a thorough investigation, we have strong reason to believe that the peer review process was failure and, after review and contacting the authors, the editors of Genetics and Molecular Research decided to retract the article in accordance with the recommendations of the Committee on Publication Ethics (COPE). The authors and their institutions were advised of this serious breach of ethics.

22nd September 2010 - Korean Minister of Education, Science and Technology J.-H. Lee signing the guest book and exchanging gifts with CERN Director-General R. Heuer and Head of International Relations F. Pauss; visiting ALICE exhibition with Collaboration Spokesperson J. Schukraft; accompanied throughout by Adviser R. Voss.

CERN Multimedia

Teams : M. Brice ; JC Gadmer

2010-01-01

22nd September 2010 - Korean Minister of Education, Science and Technology J.-H. Lee signing the guest book and exchanging gifts with CERN Director-General R. Heuer and Head of International Relations F. Pauss; visiting ALICE exhibition with Collaboration Spokesperson J. Schukraft; accompanied throughout by Adviser R. Voss.

Perspectives on extended Deterrence

International Nuclear Information System (INIS)

Tertrais, Bruno; Yost, David S.; Bunn, Elaine; Lee, Seok-soo; Levite, Ariel e.; Russell, James A.; Hokayem, Emile; Kibaroglu, Mustafa; Schulte, Paul; Thraenert, Oliver; Kulesa, Lukasz

2010-05-01

In November 2009, the Foundation for Strategic Research (Fondation pour la recherche strategique, FRS) convened a workshop on 'The Future of extended Deterrence', which included the participation of some of the best experts of this topic, from the United States, Europe, the Middle East and East Asia, as well as French and NATO officials. This document brings together the papers prepared for this seminar. Several of them were updated after the publication in April 2010 of the US Nuclear Posture Review. The seminar was organized with the support of the French Atomic energy Commission (Commissariat a l'energie atomique - CEA). Content: 1 - The future of extended deterrence: a brainstorming paper (Bruno Tertrais); 2 - US extended deterrence in NATO and North-East Asia (David S. Yost); 3 - The future of US extended deterrence (Elaine Bunn); 4 - The future of extended deterrence: a South Korean perspective (Seok-soo Lee); 5 - Reflections on extended deterrence in the Middle East (Ariel e. Levite); 6 - extended deterrence, security guarantees and nuclear weapons: US strategic and policy conundrums in the Gulf (James A. Russell); 7 - extended deterrence in the Gulf: a bridge too far? (Emile Hokayem); 8 - The future of extended deterrence: the case of Turkey (Mustafa Kibaroglu); 9 - The future of extended deterrence: a UK view (Paul Schulte); 10 - NATO and extended deterrence (Oliver Thraenert); 11 - extended deterrence and assurance in Central Europe (Lukasz Kulesa)

Influence of cationic lipid concentration on properties of lipid–polymer hybrid nanospheres for gene delivery

Directory of Open Access Journals (Sweden)

Bose RJC

2015-09-01

Full Text Available Rajendran JC Bose,1,2 Yoshie Arai,1 Jong Chan Ahn,1 Hansoo Park,2 Soo-Hong Lee11Department of Biomedical Science, College of Life Science, CHA University, Seongnam, 2Department of Integrative Engineering, Chung-Ang University, Seoul, South Korea Abstract: Nanoparticles have been widely used for nonviral gene delivery. Recently, cationic hybrid nanoparticles consisting of two different materials were suggested as a promising delivery vehicle. In this study, nanospheres with a poly(D,l-lactic-co-glycolic acid (PLGA core and cationic lipid shell were prepared, and the effect of cationic lipid concentrations on the properties of lipid polymer hybrid nanocarriers investigated. Lipid–polymer hybrid nanospheres (LPHNSs were fabricated by the emulsion-solvent evaporation method using different concentrations of cationic lipids and characterized for size, surface charge, stability, plasmid DNA-binding capacity, cytotoxicity, and transfection efficiency. All LPHNSs had narrow size distribution with positive surface charges (ζ-potential 52–60 mV, and showed excellent plasmid DNA-binding capacity. In vitro cytotoxicity measurements with HEK293T, HeLa, HaCaT, and HepG2 cells also showed that LPHNSs exhibited less cytotoxicity than conventional transfection agents, such as Lipofectamine and polyethyleneimine–PLGA. As cationic lipid concentrations increased, the particle size of LPHNSs decreased while their ζ-potential increased. In addition, the in vitro transfection efficiency of LPHNSs increased as lipid concentration increased. Keywords: core–shell hybrid nanospheres, lipid concentration, surface modification, low cytotoxicity, transfection efficiency

The effects of Hurricane Irene and Tropical Storm Lee on the bed sediment geochemistry of U.S. Atlantic coastal rivers

Science.gov (United States)

Horowitz, Arthur J.

2013-01-01

Hurricane Irene and Tropical Storm Lee, both of which made landfall in the U.S. between late August and early September 2011, generated record or near record water discharges in 41 coastal rivers between the North Carolina/South Carolina border and the U.S./Canadian border. Despite the discharge of substantial amounts of suspended sediment from many of these rivers, as well as the probable influx of substantial amounts of eroded material from the surrounding basins, the geochemical effects on the TOC), total nitrogen (TN), Zn, Se, Co, Cu, Pb, As, Cr, and total carbon (TC). As a group, these constituents tend to be associated either with urbanization/elevated population densities and/or wastewater/solid sludge. The limited number of significant sediment-associated chemical changes that were detected probably resulted from two potential processes: (1) the flushing of in-stream land-use affected sediments that were replaced by baseline material more representative of local geology and/or soils (declining concentrations), and/or (2) the inclusion of more heavily affected material as a result of urban nonpoint-source runoff and/or releases from flooded treatment facilities (increasing concentrations). Published 2013. This article is a U.S. Government work and is in the public domain in the USA.

Economic value of angling on the Colorado River at Lees Ferry: Using secondary data to estimate the influence of seasonality

Science.gov (United States)

Bair, Lucas S.; Rogowski, David L.; Neher, Christopher

2016-01-01

Glen Canyon Dam (GCD) on the Colorado River in northern Arizona provides water storage, flood control, and power system benefits to approximately 40 million people who rely on water and energy resources in the Colorado River basin. Downstream resources (e.g., angling, whitewater floating) in Glen Canyon National Recreation Area (GCNRA) and Grand Canyon National Park are impacted by the operation of GCD. The GCD Adaptive Management Program was established in 1997 to monitor and research the effects of dam operations on the downstream environment. We utilized secondary survey data and an individual observation travel cost model to estimate the net economic benefit of angling in GCNRA for each season and each type of angler. As expected, the demand for angling decreased with increasing travel cost; the annual value of angling at Lees Ferry totaled US$2.7 million at 2014 visitation levels. Demand for angling was also affected by season, with per-trip values of $210 in the summer, $237 in the spring, $261 in the fall, and $399 in the winter. This information provides insight into the ways in which anglers are potentially impacted by seasonal GCD operations and adaptive management experiments aimed at improving downstream resource conditions.

Los géneros efímeros: el caso del programa de mano

OpenAIRE

Sánchez, Sandra

2014-01-01

Fil: Di Stéfano, Mariana. Universidad Nacional de las Artes. Área Transdepartamental de Crítica de Artes. Instituto de Investigación y Experimentación en Arte y Crítica; Argentina Fil: Sánchez, Sandra. Universidad Nacional de las Artes. Área Transdepartamental de Crítica de Artes. Instituto de Investigación y Experimentación en Arte y Crítica; Argentina Fil: Sánchez, Sandra. Universidad de Ciencias Empresariales y Sociales; Facultad de Ciencias de la Comunicación; Argentina. Fil: Di ...

Scaled particle theory for a hard spherocylinder fluid in a disordered porous medium: Carnahan-Starling and Parsons-Lee corrections

Directory of Open Access Journals (Sweden)

M.F. Holovko

2018-03-01

Full Text Available The scaled particle theory (SPT approximation is applied for the study of the influence of a porous medium on the isotropic-nematic transition in a hard spherocylinder fluid. Two new approaches are developed in order to improve the description in the case of small lengths of spherocylinders. In one of them, the so-called SPT-CS-PL approach, the Carnahan-Starling (CS correction is introduced to improve the description of thermodynamic properties of the fluid, while the Parsons-Lee (PL correction is introduced to improve the orientational ordering. The second approach, the so-called SPT-PL approach, is connected with generalization of the PL theory to anisotropic fluids in disordered porous media. The phase diagram is obtained from the bifurcation analysis of a nonlinear integral equation for the singlet distribution function and from the thermodynamic equilibrium conditions. The results obtained are compared with computer simulation data. Both ways and both approaches considerably improve the description in the case of spherocylinder fluids with smaller spherocylinder lengths. We did not find any significant differences between the results of the two developed approaches. We found that the bifurcation analysis slightly overestimates and the thermodynamical analysis underestimates the predictions of the computer simulation data. A porous medium shifts the phase diagram to smaller densities of the fluid and does not change the type of the transition.

Silicon improves salt tolerance by increasing root water uptake in Cucumis sativus L.

Science.gov (United States)

Zhu, Yong-Xing; Xu, Xuan-Bin; Hu, Yan-Hong; Han, Wei-Hua; Yin, Jun-Liang; Li, Huan-Li; Gong, Hai-Jun

2015-09-01

Silicon enhances root water uptake in salt-stressed cucumber plants through up-regulating aquaporin gene expression. Osmotic adjustment is a genotype-dependent mechanism for silicon-enhanced water uptake in plants. Silicon can alleviate salt stress in plants. However, the mechanism is still not fully understood, and the possible role of silicon in alleviating salt-induced osmotic stress and the underlying mechanism still remain to be investigated. In this study, the effects of silicon (0.3 mM) on Na accumulation, water uptake, and transport were investigated in two cucumber (Cucumis sativus L.) cultivars ('JinYou 1' and 'JinChun 5') under salt stress (75 mM NaCl). Salt stress inhibited the plant growth and photosynthesis and decreased leaf transpiration and water content, while added silicon ameliorated these negative effects. Silicon addition only slightly decreased the shoot Na levels per dry weight in 'JinYou 1' but not in 'JinChun 5' after 10 days of stress. Silicon addition reduced stress-induced decreases in root hydraulic conductivity and/or leaf-specific conductivity. Expressions of main plasma membrane aquaporin genes in roots were increased by added silicon, and the involvement of aquaporins in water uptake was supported by application of aquaporin inhibitor and restorative. Besides, silicon application decreased the root xylem osmotic potential and increased root soluble sugar levels in 'JinYou 1.' Our results suggest that silicon can improve salt tolerance of cucumber plants through enhancing root water uptake, and silicon-mediated up-regulation of aquaporin gene expression may in part contribute to the increase in water uptake. In addition, osmotic adjustment may be a genotype-dependent mechanism for silicon-enhanced water uptake in plants.

Die wese, doel en belangrikheid van liggaamlike opvoeding in 'n moderne kulturele samelewing en die prinsipiële grondbeginsels waarop dit moet berus*

Directory of Open Access Journals (Sweden)

I. R. van der Merwe

1963-03-01

Full Text Available Om dat die begrip Liggaamlike Opvoeding in die alledaagsc taalgebruik ligtclik assosieer word o.a. m et sulke begrippe soos sport, liggaamsoefeninge, in Engels m et physical culture; in Duits m et kórpcrerziehung; in Grieks met gym nastiek en andcr moontlike m isleidende begrippe in aanverw ante tale, en om dat in die alledaagse spreek- taal daar wanopvattings ook kan bestaan i.v.m. so ’n begrip soos kultuur, wil ons dan ten einde m isverstand uit die weg te ruim , vir eers kortliks nagaan w at presies onder die begrippe K ultuur en Liggaamlike Opvoeding verstaan moet word voordat ’n poging aangewend w ord om bogenoemde onderwerp te ondersoek.

"Improtest" kui "improbleem" / Tõnis Kahu

Index Scriptorium Estoniae

Kahu, Tõnis, 1962-

2009-01-01

Improvisatsioonilise muusika kontserdisarjast "Improtest", sarja hooaja avakontserdist, kus esines prantsuse kitarrist Jean-Francois Pauvros. "Improtesti" eestvedajad Taavi Kerikmäe ja Mart Soo vastavad küsimustele

Kuula. Kuu artist Sam Sparro. Kuu plaat / Mart Juur

Index Scriptorium Estoniae

Juur, Mart, 1964-

2008-01-01

Artistist Sam Sparrost. Heliplaatidest: "Sex And The City" Original Motion Picture Soundtrack, "Maestro: Blue Note Trip", Melvin/Soo/Remmel/Julm "Geografix", Alanis Morrisette "Flavors Of Entanglement", Guillemots "Red"

A contemplation in negation and emphasizes of outstanding philosophers of Tehran philosophy school in immortality of subject in substantial movement.

Directory of Open Access Journals (Sweden)

mohamad khosravi farsani

2015-03-01

Full Text Available Agha Ali and Jelveh ,two of outstanding of Tehran philosophy school, have reconsidered Sandra's opinions in two opposite sides. Agha Ali is the claimant of negation and ambiguity in most of Sandra's opinions while emphasizing on transcendent theosophy foundations ,and he tries to make these ambiguities clear .However , Jelveh follows Avicenna's way and has the idea of criticizing Sandra .This article has chosen the problem Of immortality of subject in substantial movement between all debates of these two philosophers of the same age.in this essay we are going to survey Agha Ali's claims in his new explantation in one hand ,and survey and criticize the new explanation of Jelveh in negation Of substantial movement .One of the consequences of surveying and criticizing these two philosophers is that we recognize Agha Ali has succeeded in making Sadra's opinions clear by presenting a new explanation of substantial movement subject. However ,Jelveh has merged Sadra's opinions with Avicenna's instead of debilitating Sadra's opinions and stabilizing Avicenna's opinions.

Candidate genes for COPD: current evidence and research

Directory of Open Access Journals (Sweden)

Kim WJ

2015-10-01

Full Text Available Woo Jin Kim,1 Sang Do Lee2 1Department of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon, 2Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea Abstract: COPD is a common complex disease characterized by progressive airflow limitation. Several genome-wide association studies (GWASs have discovered genes that are associated with COPD. Recently, candidate genes for COPD identified by GWASs include CHRNA3/5 (cholinergic nicotine receptor alpha 3/5, IREB2 (iron regulatory binding protein 2, HHIP (hedgehog-interacting protein, FAM13A (family with sequence similarity 13, member A, and AGER (advanced glycosylation end product–specific receptor. Their association with COPD susceptibility has been replicated in multiple populations. Since these candidate genes have not been considered in COPD, their pathological roles are still largely unknown. Herein, we review some evidences that they can be effective drug targets or serve as biomarkers for diagnosis or subtyping. However, more study is required to understand the functional roles of these candidate genes. Future research is needed to characterize the effect of genetic variants, validate gene function in humans and model systems, and elucidate the genes’ transcriptional and posttranscriptional regulatory mechanisms. Keywords: chronic obstructive pulmonary disease, genetics, genome-wide association study

Gevalle van positiewe taalbeplanning soos gerapporteer in die ...

African Journals Online (AJOL)

Southern African Linguistics and Applied Language Studies ... Conversely, however, cases of positive language planning in respect of the languages ... generally and enthusiastically treated as part of a general policy, it would not have been ...

Kuidas tagada efektiivne riigi õigusabi kriminaalmenetluses? / Anneli Soo

Index Scriptorium Estoniae

Soo, Anneli, 1984-

2014-01-01

Riigi vastutusest efektiivse kaitse õiguse rikkumise korral. Kohtulikust järelevalvest kaitsjate tegevuse üle kriminaalmenetluses. Efektiivse süsteemi väljatöötamisest riigi õigusabi andmiseks

Remote monitoring of chlorophyll fluorescence in two reef corals during the 2005 bleaching event at Lee Stocking Island, Bahamas

Science.gov (United States)

Manzello, D.; Warner, M.; Stabenau, E.; Hendee, J.; Lesser, M.; Jankulak, M.

2009-03-01

Zooxanthellae fluorescence was measured in situ, remotely, and in near real-time with a pulse amplitude modulated (PAM) fluorometer for a colony of Siderastrea siderea and Agaricia tenuifolia at Lee Stocking Island, Bahamas during the Caribbean-wide 2005 bleaching event. These colonies displayed evidence of photosystem II (PS II) inactivation coincident with thermal stress and seasonally high doses of solar radiation. Hurricane-associated declines in temperature and light appear to have facilitated the recovery of maximum quantum yield of PS II within these two colonies, although both corals responded differently to individual storms. PAM fluorometry, coupled with long-term measurement of in situ light and temperature, provides much more detail of coral photobiology on a seasonal time scale and during possible bleaching conditions than sporadic, subjective, and qualitative observations. S. siderea displayed evidence of PS II inactivation over a month prior to the issuing of a satellite-based, sea surface temperature (SST) bleaching alert by the National Oceanic and Atmospheric Administration (NOAA). In fact, recovery had already begun in S. siderea when the bleaching alert was issued. Fluorescence data for A. tenuifolia were difficult to interpret because the shaded parts of a colony were monitored and thus did not perfectly coincide with thermal stress and seasonally high doses of solar radiation as in S. siderea. These results further emphasize the limitations of solely monitoring SST (satellite or in situ) as a bleaching indicator without considering the physiological status of coral-zooxanthellae symbioses.

The contributions of Donald Lee Johnson to understanding the Quaternary geologic and biogeographic history of the California Channel Islands

Science.gov (United States)

Muhs, Daniel R.

2013-01-01

Over a span of 50 years, native Californian Donald Lee Johnson made a number of memorable contributions to our understanding of the California Channel Islands. Among these are (1) recognizing that carbonate dunes, often cemented into eolianite and derived from offshore shelf sediments during lowered sea level, are markers of glacial periods on the Channel Islands; (2) identifying beach rock on the Channel Islands as the northernmost occurrence of this feature on the Pacific Coast of North America; (3) recognizing of the role of human activities in historic landscape modification; (4) identifying both the biogenic and pedogenic origins of caliche “ghost forests” and laminar calcrete forms on the Channel Islands; (5) providing the first soil maps of several of the islands, showing diverse pathways of pedogenesis; (6) pointing out the importance of fire in Quaternary landscape history on the Channel Islands, based on detailed stratigraphic studies; and (7), perhaps his greatest contribution, clarifying the origin of Pleistocene pygmy mammoths on the Channel Islands, due not to imagined ancient land bridges, but rather the superb swimming abilities of proboscideans combined with lowered sea level, favorable paleowinds, and an attractive paleovegetation on the Channel Islands. Don was a classic natural historian in the great tradition of Charles Darwin and George Gaylord Simpson, his role models. Don’s work will remain important and useful for many years and is an inspiration to those researching the California Channel Islands today.

Flux of nitrogen, phosphorus, and suspended sediment from the Susquehanna River Basin to the Chesapeake Bay during Tropical Storm Lee, September 2011, as an indicator of the effects of reservoir sedimentation on water quality

Science.gov (United States)

Hirsch, Robert M.

2012-01-01

Concentrations of nitrogen, phosphorus, and suspended sediment are measured at the U.S. Geological Survey streamgage at Conowingo Dam at the downstream end of the Susquehanna River Basin in Maryland, where the river flows into the Chesapeake Bay. During the period September 7-15, 2011, in the aftermath of Tropical Storm Lee, concentrations of these three constituents were among the highest ever measured at this site. These measurements indicate that sediment-storage processes behind the three dams on the lower Susquehanna River are evolving. In particular, they indicate that scouring of sediment (and the nitrogen and phosphorus attached to that sediment) may be increasing with time. Trends in flow-normalized fluxes at the Susquehanna River at Conowingo, Maryland, streamgage during 1996-2011 indicate a 3.2-percent decrease in total nitrogen, but a 55-percent increase in total phosphorus and a 97-percent increase in suspended sediment. These large increases in the flux of phosphorus and sediment from the Susquehanna River to the Chesapeake Bay have occurred despite reductions in the fluxes of these constituents from the Susquehanna River watershed upstream from the reservoirs. Although the Tropical Storm Lee flood event contributed about 1.8 percent of the total streamflow from the Susquehanna River to the Chesapeake Bay over the past decade (water years 2002-11), it contributed about 5 percent of the nitrogen, 22 percent of the phosphorus, and 39 percent of the suspended sediment during the same period. These results highlight the importance of brief high-flow events in releasing nitrogen, phosphorus, and sediment derived from the Susquehanna River watershed and stored in the Conowingo Reservoir to the Chesapeake Bay.

Provenance and indirect dating study on Hongzhou Kiln porcelains by INAA

International Nuclear Information System (INIS)

Feng, X.Q.; Feng, S.L.; Fan, C.S.; Zhang, W.J.; Quan, K.S.

2005-01-01

Hongzhou Kiln is one of the six leading celadon kilns in Tang Dynasty and plays an important role in the history of Chinese ceramics for its diverse decoration styles and innovative technology. Archaeologists divided Hongzhou Kiln production into 8 periods, i.e. Eastern Han and Eastern Wu, Western Jin, Eastern Jin, Southern Dynasties, Sui, Early Tang, Middle Tang, Late Tang and Five Dynasties. Up to now, 26 kiln sites have been discovered and excavated. A study on the chemical composition of the porcelains of different periods and provenance will help to know the developing process of Hongzhou celadon such as variation of raw materials, recipes, manufacturing technology, causes of prosperity and decline, etc. Over 200 sherds were collected and their body samples were analyzed by INAA. The compositional differences between samples with the same period but different provenance were observed. The contents of Na, Rb, Ba, Fe, Th, U, etc were found to be different among samples from different periods, which implies they may be used to identify the manufacturing age. The analytical data were further processed by principal component analysis (PCA). The statistical results show that all the sherds can be classified into 5 groups, (1) Eastern Han and Eastern Wu; (2) Western Jin, Eastern Jin and Southern Dynasties; (3) Sui; (4) Early Tang and Middle Tang; (5) Late Tang and Five Dynasties.

Production and characterization of pectinases obtained from ...

African Journals Online (AJOL)

Production and characterization of pectinases obtained from Aspergillus fumigatus in submerged fermentation system using pectin extracted from mango peels as carbon source. AL Ezugwu, SOO Eze, FC Chilaka, CU Anyanwu ...

11 Resensie-artikel Stimie WEB 02.pmd

African Journals Online (AJOL)

Owner

Keywords: Afrikaans oratorio, classical music, corporate entertainment. .... soos FNB, Morning Star Express Hotel, kykNET, Packed House Productions, .... of feeling which represents the character of the people who speak that language.

Debora Vaarandi kodumaa / Maie Kalda

Index Scriptorium Estoniae

Kalda, Maie, 1929-2013

2007-01-01

Debora Vaarandi luulest: "Põleva laotuse linn", "Kohav rand", "Talgud Lööne soos", "Selgel hommikul", "Nii ma näen Eestimaad", "Unistaja aknal" ja "Rannalageda leib", "Eesti mullad". Ka Põhjamaa-teemast

AVA Muusika plaadistab loova mõtlemisega artiste

Index Scriptorium Estoniae

2004-01-01

AVA Muusika tegevusest eesti alternatiivse uue muusika salvestamisel, esimesest heliplaadist duo Erdmann/Sooäär Dessert Time'i ühisest albumist "Peer Gynt & Other Stories", plaadi esitlusest 5. nov. Berliinis

Zinc oxide nanoparticles: a 90-day repeated-dose dermal toxicity study in rats

Directory of Open Access Journals (Sweden)

Ryu HJ

2014-12-01

Full Text Available Hwa Jung Ryu,1,* Mu Yeb Seo,2,* Sung Kyu Jung,1 Eun Ho Maeng,2 Seung-Young Lee,2 Dong-Hyouk Jang,2 Taek-Jin Lee,2 Ki-Yeon Jo,2 Yu-Ri Kim,3 Kyu-Bong Cho,4 Meyoung-Kon Kim,3 Beom Jun Lee,5 Sang Wook Son1 1Department of Dermatology, Korea University College of Medicine, Seoul, 2Korea Testing and Research Institute, Gyunggido, 3Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, 4Department of Clinical Laboratory Science, Shinheung College, Uijeongbu, 5College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea *These authors contributed equally to this work and both should be considered first authors Abstract: Zinc oxide (ZnO works as a long-lasting, broad-spectrum physical sunblock, and can prevent skin cancer, sunburn, and photoaging. Nanosized ZnO particles are used often in sunscreens due to consumer preference over larger sizes, which appear opaque when dermally applied. Although the US Food and Drug Administration approved the use of nanoparticles (NPs in sunscreens in 1999, there are ongoing safety concerns. The aim of this study was to evaluate the subchronic toxicity of ZnO NPs after dermal application according to the Organization for Economic Cooperation and Development Test Guidelines 411 using Good Laboratory Practice. Sprague Dawley rats were randomly divided into eight (one control, one vehicle control, three experimental, and three recovery groups. Different concentrations of ZnO NPs were dermally applied to the rats in the experimental groups for 90 days. Clinical observations as well as weight and food consumption were measured and recorded daily. Hematology and biochemistry parameters were determined. Gross pathologic and histopathologic examinations were performed on selected tissues from all animals. Analyses of tissue were undertaken to determine target organ tissue distribution. There was no increased mortality in the experimental group. Although there

The Optimal Technological Development Path to Reduce Pollution and Restructure Iron and Steel Industry for Sustainable Transition

OpenAIRE

Ren, M.; Xu, X.; Ermolieva, T.; Cao, G.-Y.; Yermoliev, Y.

2018-01-01

China is the world’s largest iron and steel producer and Jing-Jin-Ji (Beijing-Tianjin-Hebei) region accounts for nearly 1/3 of the national iron and steel production, while it is facing serious air pollution. Among the top 10 worst polluted cities in China, seven were located in Hebei province in 2014. Recent years Jing-Jin-Ji region has been promoted iron & steel industry with green clean technology for accelerating sustainable economic transition. This paper tries to response the basic ques...

Eesti 15-16 aastaste koolinoorte uimastitarbimine : 1995., 1999. ja 2003. aasta uurimuste võrdlus / Airi-Alina Allaste

Index Scriptorium Estoniae

Allaste, Airi-Alina, 1967-

2004-01-01

Rahvusvaheliste uurimuste ESPAD käigus koguti andmeid uimastite tarvitamisega seotud käitumise kohta koolinoorte hulgas; Joon.: uimastite tarvitamine soo ja õppekeele järgi, tubakaga katsetajad ja regulaarsed suitsetajad, kanepisuitsetajad

Download this PDF file

African Journals Online (AJOL)

2009-08-03

Aug 3, 2009 ... Leefwysesiektes soos obesiteit word verwaarloos in ontwikkelende lande weens die fokus op ..... the 25% attributable to infectious diseases (Bradshaw et al. .... UNESCO Institute for Statistics, 2008, Glossary: Pupil-teacher.

Association of blood eosinophils and plasma periostin with FEV1 response after 3-month inhaled corticosteroid and long-acting beta2-agonist treatment in stable COPD patients

Directory of Open Access Journals (Sweden)

Park HY

2015-12-01

Full Text Available Hye Yun Park,1 Hyun Lee,1 Won-Jung Koh,1 Seonwoo Kim,2 Ina Jeong,3 Hyeon-Kyoung Koo,4 Tae-Hyung Kim,5 Jin Woo Kim,6 Woo Jin Kim,7 Yeon-Mok Oh,8 Don D Sin,9 Seong Yong Lim,10,* Sang-Do Lee8,* On behalf of the KOLD Study Group 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 2Biostatistics Team, Samsung Biomedical Research Institute, Seoul, Korea; 3Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Medical Center, Seoul, Korea; 4Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea; 5Division of Pulmonary and Critical Care Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Gyeonggi-do, Korea; 6Division of Pulmonology, Department of Internal Medicine, Uijeongbu St Mary’s Hospital, Gyunggi-do, Korea; 7Department of Internal Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Korea; 8Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; 9Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, BC, Canada; 10Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea *These authors contributed equally to this work Background: COPD patients with increased airway eosinophilic inflammation show a favorable response to inhaled corticosteroids (ICS in combination with a long-acting bronchodilator. Recent studies have demonstrated a significant correlation of sputum eosinophilia with blood eosinophils and periostin. We investigated whether high blood eosinophils and plasma periostin were associated

NANOTECHNOLOGY, NANOMEDICINE; ETHICAL ASPECTS.

Science.gov (United States)

Gökçay, Banu; Arda, Berna

2015-01-01

Nanotechnology is a field that we often hear of its name nowadays. Altough what we know about it is soo poor, we admire this field of technlogy, moreover some societies even argues that nanotechnology will cause second endustrial revolution. In addition, nanotechnology makes our basic scientific knowledge upside down and is soo powerfull that it is potent in nearly every scientific field. Thereby, it is imposible to say that nanotechnology; which is soo effective on human and human life; will not cause social and ethical outcomes. In general, the definition of nanotechnology is the reconfiguration of nanomaterials by human; there also are different definitions according to the history of nanotechnology and different point of views. First of all, in comparison to the other tehnology fields, what is the cause of excellence of nanotechnology, what human can do is to foresee the advantages and disadvantages of it, what are the roles of developed and developping countries for the progression of nanotechnology, what is the attitude of nanoethics and what is view of global politics to nanotechological research according to international regulations are all the focus of interests of this study. Last but not least, our apprehension capacity of nanotechnology, our style of adoption and evaluation of it and the way that how we locate nanotechnology in our lifes and ethical values are the other focus of interests.

Hydrological influences on long-term gas flow trends at locations in the Vogtland/NW Bohemian seismic region (German-Czech border

Directory of Open Access Journals (Sweden)

J. Heinicke

2007-06-01

Full Text Available One of the typical methods for the identification of seismo-hydrological effects is to monitor changes in the free gas flow throughout springs or mofettes. For several years, the gas flow regime of mineral springs at Bad Brambach (Germany and mofettes in the Nature Park Soos (Czech Republic and its dependence on hydro-/meteorological parameters have been studied. The mineral spring ‘Wettinquelle’, Bad Brambach, is a well-known seismo- hydrologically sensitive location for swarmquakes at a special epicentral area of NW Bohemia. Since 2000, a slight upward trend in the gas flow of three Bad Brambach mineral springs has been observed, which became stronger after the ‘Eisenquelle’ spring capture reconstruction (winter 2003/2004. Similar behaviour could be detected at a mofette in Soos. The results correspond to a 3He/4He mantle ratio increase in gases at mofettes in the Cheb Basin (CZ traced by other authors for more than 12 years, and could give hints for a higher degassing activity of the magma body below that area. Common and special properties in the degassing regimes of the Bad Brambach and Soos locations are discussed. It is demonstrated that the long-term gas flow trend was interrupted in 2003 because of very low groundwater levels. This effect was amplified by the artificial groundwater lowering during the ‘Eisenquelle’ spring capture reconstruction.

Pärnu kunstnikud tagasi kodus / Sandra Jõgeva

Index Scriptorium Estoniae

Jõgeva, Sandra, 1976-

2011-01-01

Pärnust pärit kunstnike näitus "Tagasi koju" Pärnu Linnagaleriis 13. augustini 2011. Kuraator Mari Kartau, kunstnikud Kaarel Kurismaa, Mari Kurismaa, Malle Leis, Marco Laimre, Maiu Rõõmus, Flo Kasearu, Elin Kard

Kaasaegne kunst kui ekstreemne meelelahutus / Sandra Jõgeva

Index Scriptorium Estoniae

Jõgeva, Sandra, 1976-

2005-01-01

Tutvustatakse kümmet kaasaegset kunstirühmitust ja -projekti: USA anonüümne kollektiiv The Yes Men, rahvusvaheline rühmitus The Biotic Pie Bacing Brigade, Hispaania rühmitus Yomango, taani disainerite rühmitus N55, poolaka Krzystof Wodiczko projekt, USA rühmitus Basekamp, Austraalia tegevuskunstniku Stelarc' projekt, USA rühmitus Pink Bloque ja Inglismaa rühmitus My Dads Strip Club

Lagunenud valitsusega Pakistan vaevleb kriisis / Sandra Maasalu

Index Scriptorium Estoniae

Maasalu, Sandra

2008-01-01

Ilmunud ka: Postimees : na russkom jazõke 27. aug. 2008, lk. 7. Pakistani valitsuse lagunemisest, kui endine peaminister Navaz Sharif oma parteiga koalitsioonist lahkus. Vt. samas: Pakistani ahistavad separatistid ja majanduse allakäik. Kaart: Pakistan

Statistika = Statistics

Index Scriptorium Estoniae

2004-01-01

Andmeid maksuameti töötajate jagunemisest hariduse, soo, staazhi, vanuse järgi; koolitused 2001-2003, koolitusel osalejate arv; füüsilise isiku tuludeklaratsioon; tulu- ja sotsiaalmaksu maksudeklaratsioon; käibedeklaratsioon

Phillip Louw: Oxford Afrikaans-Engels / English-Afrikaans Skoolwoordeboek / School Dictionary

Directory of Open Access Journals (Sweden)

Anton F. Prinsloo

2011-10-01

Full Text Available Die Oxford Afrikaans–Engels/English–Afrikaans Skoolwoordeboek is as skoolwoor-deboek 'n puik hulpbron vir leerders. Dit is egter meer as net 'n woordeboek, soos wat 'n oorsig dadelik toon.

Plaadid / Kaur Garshnek, Ave Randviir, Priit Pruul...[jt.

Index Scriptorium Estoniae

2007-01-01

Uutest heliplaatidest Jaak Sooäär, Raul Vaigla, Tanel Ruben "No99 Jazzklubis", Black Strobe "Burn Your Own Church", The Quantic Soul Orchestra "Tropidelico", Uni "Kosmikud II", Bugge Wesseltoft "IM", Gabrielle "Always"

Jiná avantgarda? Poznámky

Czech Academy of Sciences Publication Activity Database

Vojtěch, Daniel

Roč. 56, č. 5 ( 2008 ), s. 709-713 ISSN 0009-0468 Institutional research plan: CEZ:AV0Z90560517 Keywords : Czech literature * Avant-garde * modernism Subject RIV: AJ - Letters, Mass-media, Audiovision

Kritiese geletterdheid: Die ontmoeting tussen die Westerse sekularisme en Islamitiese spiritualiteit in geselekteerde romans vir jong volwasseness – 'n benadering

Directory of Open Access Journals (Sweden)

Salome Romylos

2016-11-01

Full Text Available Hierdie artikel het ten doel om aan te toon dat die geselekteerde romans vir jong volwassenes potensieel kragtige ruimtes kan wees vir die skep van ’n bewustheid en beter begrip van Moslems, Islam, en veral van die dra van sluiers en kopdoeke. Kritiese geletterdheid as ’n metodologie word gebruik om te demonstreer hoe leerders gelei kan word om krities betrokke te raak by tekste. Dit is noodsaaklik, omdat blote oppervlakkennis nie genoeg is wanneer leerders gekonfronteer word met ingewikkelde kwessies soos ras, spiritualiteit en kultuur nie. Westerse televisie, koerante en tydskrifte skilder ’n baie eensydige beeld van Moslems as ’n naatloos homogene groep. Baie jong volwassenes neem aktief deel aan gesprekke op digitale media, soos Twitter en Facebook, waar kwessies van kultuur en diversiteit gereeld ter sprake kom. Westerlinge kan baie negatiewe persepsies van Islam en Moslems vorm wanneer hulle oorval word met ’n stortvloed beelde van gruwelikhede wat uitgevoer word deur ekstremistegroepe soos die Islamitiese Staat van Irak en die Ooste (ISIS. Die gevolg is dat alle Moslems gestereotipeer word as fundamentaliste, terroriste en onderdrukkers van vroue. Hierdie kenniskonstruk word gemanipuleer deur die media. ’n Begrip van die redes waarom vroue ’n stuk lap – die kopdoek – dra, kan ’n beginpunt wees vir die verandering van persepsies van Moslems en hul verskillende praktyke. Opvoeders moet oppas om nie net verdraagsaamheid tussen verskillende kulturele groepe te verkondig nie, want verdraagsaamheid impliseer ’n blote bestuur van ’n mens se gevoelens van afsku vir dit wat verdra word. Vrae wat uit ’n standpunt van kritiese geletterdheid gestel kan word aan tekste soos The breadwinner-trilogie deur Deborah Ellis en The girl in the tangerine scarf by Mohja Kahf, word bespreek as voorbeelde wat in die klaskamer gebruik kan word. Hierdie tekste beeld Moslemvroue en -meisies baie anders uit en kan vergelykend gelees word

Functionally Graded Material: An overview

CSIR Research Space (South Africa)

Mahamood, RM

2012-07-01

Full Text Available -3146. [50] X. Jin, L. Wu, L. Guo, H. Yu, and Y. Sun, ?Experimental investigation of the mixed-mode crack propagation in ZrO2/NiCr functionally graded materials,? Engineering Fracture Mechanics, vol. 76(12), (2009), pp. 1800-1810. [51] Z. Cheng, D. Gao... by stable crack growth,? Engineering Fracture Mechanics, vol.72(15), (2005), pp. 2359-2372. [47] Z.-H. Jin, and R.H. Dodds Jr, ?Crack growth resistance behavior of a functionally graded material: computational studies,? Engineering Fracture Mechanics...

Värske kõrvaga kuuldud uuest Eesti muusikast / Elo Masing

Index Scriptorium Estoniae

Masing, Elo

2011-01-01

Eksperimentaalset Eesti muusikat tutvustava heliplaadi "Estonian Music Now 2011 - Exploratory Music From Estonia" esitluskontserdist 31. oktoobril Londonis Cafe OTOs, kus esinesid duo Taavi Kerikmäe - Mart Soo, Taavo Remmel ning Free Tallinn Trio

Frees-jääksoode [looduslik] taimestumine / J. Paal, E. Leiner, T. Paal, T. Triisberg

Index Scriptorium Estoniae

2011-01-01

Lui looduslikus soos levivad paljud taimed eelkõige vegetatiivselt, siis jääksoos, eriti kui see ei piirne loodusliku sooga, seda toimuda ei saa, seega jääb seemneline uuendumine peamiselt tuulekandeliseks

Adapting a historical dictionary for the modern online user: The case ...

African Journals Online (AJOL)

user

accommodate new users and to bring the DSAEHist into the digital era (with regard to standard web and mobile ... digitale era. Soos met talle ander gedrukte woordeboeke wat omgeskakel word na elektroniese ...... marketing perspective.

Time-lapse analysis of methane quantity in Mary Lee group of coal seams using filter-based multiple-point geostatistical simulation

Science.gov (United States)

Karacan, C. Özgen; Olea, Ricardo A.

2013-01-01

Coal seam degasification and its success are important for controlling methane, and thus for the health and safety of coal miners. During the course of degasification, properties of coal seams change. Thus, the changes in coal reservoir conditions and in-place gas content as well as methane emission potential into mines should be evaluated by examining time-dependent changes and the presence of major heterogeneities and geological discontinuities in the field. In this work, time-lapsed reservoir and fluid storage properties of the New Castle coal seam, Mary Lee/Blue Creek seam, and Jagger seam of Black Warrior Basin, Alabama, were determined from gas and water production history matching and production forecasting of vertical degasification wellbores. These properties were combined with isotherm and other important data to compute gas-in-place (GIP) and its change with time at borehole locations. Time-lapsed training images (TIs) of GIP and GIP difference corresponding to each coal and date were generated by using these point-wise data and Voronoi decomposition on the TI grid, which included faults as discontinuities for expansion of Voronoi regions. Filter-based multiple-point geostatistical simulations, which were preferred in this study due to anisotropies and discontinuities in the area, were used to predict time-lapsed GIP distributions within the study area. Performed simulations were used for mapping spatial time-lapsed methane quantities as well as their uncertainties within the study area.

Contribution to thermodynamics and kinetics of argon, krypton and xenon at very low temperatures; Contribution a l'etude thermodynamique et cinetique de l'argon, du krypton et du xenon aux tres basses temperatures

Energy Technology Data Exchange (ETDEWEB)

Levenson, L L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1969-07-01

A critical analysis of the main theories of condensation, which are due to Zwanzig, Cabrera, Mc Caroll and Ehrlich, Wanlass, Armand, and Yu and Soo, is made. A condensation coefficient equal to unity is expected from these theories, except Armand and Yu and Soo, when the temperature of the gas impinging on its own solid phase is equal or less than 300 K. Using a resonating quartz microbalance the sensitivity of which is 10{sup -9} g. cm{sup 2} the experimental data agree with these theories when the temperature of the solid is less than 20 K. However the agreement must be interpreted for the more sophisticated theories of Armand and Yu and Soo. Regarding the sublimation of the rare gases one is faced with the theories of Salter, Eyring, Goodman and Armand. Within an order of magnitude the experimental data given here agree with the expected values. Moreover Armand theory is able to give the physical meaning of the observed results for argon sublimation from a krypton or a xenon crystalline substrate: localized modes of surface vibration occur. The relaxation time for the thermalization of the argon deposit is found greater than twelve hours at 25 K. (author) [French] Ce travail inclut l'etude critique des principales theories de la condensation dues a Zwanzig, Cabrera, Mc Caroll et Ehrlich, Wanlass, Armand, et Yu et Soo. Ces theories, sauf les deux dernieres, prevoient un coefficient de condensation egal a 1 lorsque le gaz incident sur son propre solide a une temperature inferieure ou egale a 300 K. Les mesures effectuees a l'aide d'une microbalance a quarz resonnant sensible a 10{sup -9} g. cm{sup 2} ont confirme ces theories dans le cas ou la temperature du solide est inferieure a 20 K. Cet accord doit cependant etre interprete pour les theories plus completes d'Armand d'une part, Yu et Soo d'autre part. Pour la sublimation des gaz rares on se trouve en presence des theories de Salter, Eyring, Goodman et Armand. Leurs previsions sont en accord, a un ordre de

Vintage: suvaline eriline vastikult eklektiline rohujuure disain = Vintage: arbitrary and peculiar, obnoxiously eclectic grassroots design / Karin Paulus

Index Scriptorium Estoniae

Paulus, Karin, 1975-

2013-01-01

Sisearhitekt Priit Põldme vintage stiilist. Armastusväärse kujundusega kohvikutest Eestis. Pikemalt kohvikust "Boheem" (Kopli t. 18, sisearhitekt Maris Kerge), "Kukeke" (Telliskivi t.), baarist "Pudel" (Telliskivi loomelinnak, sisekujundus: Pink) ja "Tops" (Soo t.) Tallinnas

pastorale begeleiding van die emosioneel verwonde tiener

African Journals Online (AJOL)

1 Met emosionele verwonding word verwys na die gevolge van aspekte soos verwerping ..... gevind dat getraumatiseerde kinders geneig is om hul onverwerkte trauma ..... The changing face of the South African family: single moms now the.

‘I gave them laws that were not good’ (Ezk 20:25: A biblical model of complex subjectivity and the prospects of multi-ethnic contextual reading

Directory of Open Access Journals (Sweden)

Dexter E. Callender

2014-12-01

Full Text Available The purpose of this article is to address the problem of multi-cultural multi-ethnic contextual Bible reading by giving attention to identity and subjectivity and how it is modeled both in our analyses of contemporary life and in our reconstructions of antiquity and ancient contexts. The aim here is to suggest a position that engages the question of shared values; that creates a space for dialogue between contrasting discourses; and that gives attention to the question of authenticity. I suggest that resources for such a project may be found partly in a re-engaging of biblical prophecy in light of contemporary reflection on subjectivity that embraces recent developments in the debate over modern and postmodern approaches to language and experience tied to the rise of cognitive science. Through an examination of the subject in Žižek, particularly as he engages cognitive science, and in the prophetic rhetoric of Ezekiel, this article argues for grounding multi-group reading strategies or projects on a conception of complex subjectivity that seeks to bridge contemporary discourse with the language of the biblical text. ‘Ek het vir hulle voorskrifte gegee wat nie goed was nie’ (Eseg 20:25: ’n bybelse model van komplekse subjektiwiteit en die moontlikhede van multi-etniese kontekstuele interpretasie. Die oogmerk van hierdie artikel is om die probleem van ’n multi-kulturele,multi-etniese kontekstuele lees van die Bybel te ondersoek. Met dit ten doel, gee die ondersoekaandag aan identiteit en subjektiwiteit en hoe dit gedemonstreer word in die analise van die hedendaagse sowel as in die rekonstruksie van antikwiteite en antieke kontekste. Dieuiteindelike doelwit is om ’n posisie voor te stel wat omgaan met die vraag van gedeelde waardes; wat ruimte skep vir ’n dialoog tussen teenstrydige diskoerse; en wat aandag gee aan die vraag van geloofwaardigheid. Die voorstel word gemaak dat ’n nuwe betrokkenheid by bybelse profesie in die lig van

Saline-water intrusion related to well construction in Lee County, Florida

Science.gov (United States)

Boggess, Durward Hoye; Missimer, T.M.; O'Donnell, T. H.

1977-01-01

Ground water is the principle source of water supply in Lee County, Florida where an estimated 30,000 wells have been drilled since 1990. These wells ranges in depth from about 10 to 1,240 feet and tap the water table aquifer or one or more of the artesian water-bearing units or zones in the Tamiami Formation, the upper part of the Hawthorn Formation, the lower part of the Hawthorn Formation and the Tampa Limestone and the Suwannee Limestone. Before 1968, nearly all wells were constructed with galvanized or black iron pipe. Many of these wells are sources of saline-water intrusion into freshwater-bearing zones. The water-bearing zones in the lower part of the Hawthorn Formation, Tampa Limestone, and Suwannee Limestone are artesian-they have higher water levels and usually contain water with a higher concentration of dissolved solids than do the aquifers occurring at shallower depths. The water from these deeper aquifers generally range in dissolved solids concentration from about 1,500 to 2,400 mg/L, and in chloride from about 500 to 1,00 mg/L. A maximum chloride concentration of 15,200 mg/L has been determined. Few of the 3,00 wells estimated to have been drilled to these zones contain sufficient casing to prevent upward flow into overlaying water-bearing zones. Because of water-level differentials, upward movement and lateral intrusion of saline water occurs principally into the upper part of the Hawthorn Formation where the chloride concentrations in water unaffected by saline-water intrusion ranges from about 80 to 150 mg/L. Where intrusion from deep artesian zones has occurred, the chloride concentration in water from the upper part of the Hawthorn Formation ranges from about 300 to more than 2,100 mg/L Surface discharges of the saline water from wells tapping the lower part of the Hawthorn Formation and the Suwannee Limestone also had affected the water-table aquifer which normally contains water with 10 to 50 mg/L of chloride. In one area, the chloride

Investor Laaril esimene miljon teenitud / Kertu Ruus, Raivo Sormunen

Index Scriptorium Estoniae

Ruus, Kertu, 1977-

2007-01-01

Mart Laar, Imre Sooäär ja Kristen Michal oma aktsiaportfellist ja investeerimisstrateegiast. Edetabel: Riigikogus kolm miljonärist väikeinvestorit. Tabel: Ekspeaminister Laar on investeerinud erinevatesse piirkondadesse. Kommenteerivad Peeter Luikmel ja Pertti Rahnel

Eksperiment - teeme kõige noorema Vanemuise näitleja vanaemaks

Index Scriptorium Estoniae

2010-01-01

Vanemuise teatri noorim näitleja Liisa Pulk osaleb Anne-Ly Soo (grimmiala juht) ja Erle Vannuse (jumestuskunstnik) lavagrimmi eksperimendis. Artiklis teatrigrimeerija tööst lähemalt. Lisaks näitleja CV: "Liisa Pulk"

The Napoleon Graves / Michael Tarm

Index Scriptorium Estoniae

Tarm, Michael

2002-01-01

Vilniuse lähedal leiti 1812. a. Isamaasõjas hukkunud prantsuse sõdurite matmispaik. Säilmete antropoloogilised uuringud võimaldavad kindlaks määrata hukkunute vanuse, soo ja tõenäolise surma põhjuse

Pandi ja Hanschmidti spaa sai EASilt 10 miljonit krooni / Ralf-Martin Soe

Index Scriptorium Estoniae

Soe, Ralf-Martin

2007-01-01

Ettevõtluse Arendamise Sihtasutus finantseeris 2006. aastal 10 miljoni krooniga Tallinki juhtfiguuride osalusega AS-i Heal uue spaa ehitust Haapsalus. Diagramm: Osalused AS-is Heal. Vt. samas: Kilgile ja Sooäärele samuti 10 miljonit

Atomic carbon chains as spin-transmitters: An ab initio transport study

DEFF Research Database (Denmark)

Fürst, Joachim Alexander; Brandbyge, Mads; Jauho, Antti-Pekka

2010-01-01

An atomic carbon chain joining two graphene flakes was recently realized in a ground-breaking experiment by Jin et al. (Phys. Rev. Lett., 102 (2009) 205501). We present ab initio results for the electron transport properties of such chains and demonstrate complete spin-polarization of the transmi......An atomic carbon chain joining two graphene flakes was recently realized in a ground-breaking experiment by Jin et al. (Phys. Rev. Lett., 102 (2009) 205501). We present ab initio results for the electron transport properties of such chains and demonstrate complete spin...

Transcriptome analysis and ultrastructure observation reveal that hawthorn fruit softening is due to cellulose/hemicellulose degradation

Directory of Open Access Journals (Sweden)

Jiayu Xu

2016-10-01

Full Text Available Softening, a common phenomenon in many fruits, is a well coordinated and genetically determined process. However, the process of flesh softening during ripening has rarely been described in hawthorn. In this study, we found that ‘Ruanrou Shanlihong 3 Hao’ fruits became softer during ripening, whereas ‘Qiu JinXing’ fruits remained hard. At late developmental stages, the firmness of ‘Ruanrou Shanlihong 3 Hao’ fruits rapidly declined, and that of ‘Qiu JinXing’ fruits remained essentially unchanged. According to transmission electron microscopy (TEM, the middle lamella of ‘Qiu JinXing’ and ‘Ruanrou Shanlihong 3 Hao’ fruit flesh was largely degraded as the fruits matured. Microfilaments in ‘Qiu JinXing’ flesh were arranged close together and were deep in color, whereas those in ‘Ruanrou Shanlihong 3 Hao’ fruit flesh were arranged loosely, partially degraded and light in color. RNA-Seq analysis yielded approximately 46.72 Gb of clean data and 72,837 unigenes. Galactose metabolism and pentose and glucuronate interconversions are involved in cell wall metabolism, play an important role in hawthorn texture. We identified 85 unigenes related to the cell wall between hard- and soft-fleshed hawthorn fruits. Based on data analysis and real-time PCR, we suggest that β-GAL and PE4 have important functions in early fruit softening. The genes Ffase, Gns, α-GAL, PE63, XTH and CWP, which are involved in cell wall degradation, are responsible for the different textures of hawthorn fruits. Thus, we hypothesize that the different textures of ‘Qiu JinXing’ and ‘Ruanrou Shanlihong 3 Hao’ fruits at maturity mainly result from cellulose/hemicelluloses degradation rather than from lamella degradation. Overall, we propose that different types of hydrolytic enzymes in cells interact to degrade the cell wall, resulting in ultramicroscopic Structure changes in the cell wall and, consequently, fruit softening. These results provide

Plaadid / Kaur Garshnek, Mart Niineste, Tui Hirv...[jt.

Index Scriptorium Estoniae

2008-01-01

Uutest heliplaatidest Tuule Kann/Jaak Sooäär "Õhtu ilu", The Mars Volta "The Bedlam In Goliath", Eva Dahlgren "Petroleum Och Tang", Lenny Kravitz "It's Time For A Love revolution", "Flyleaf ", New Project "Ultraviolent Light"

50 CFR 226.212 - Critical habitat for 13 Evolutionarily Significant Units (ESUs) of salmon and steelhead...

Science.gov (United States)

2010-10-01

...); Green River (47.2911, -121.9714); Jenkins Creek (47.3791, -122.0899); Little Soos Creek (47.4031, -122...) upstream to endpoint(s) in: Henry Creek (45.3328, -121.9110); Still Creek (45.2755, -121.8413); Unnamed (45...

The effectiveness of Lee Silverman Voice Treatment therapy issued interactively through an iPad device: A non-inferiority study.

Science.gov (United States)

Griffin, Murray; Bentley, John; Shanks, Joseph; Wood, Carly

2018-04-01

Introduction This study compared the differences in recorded speech variables between people treated with conventional 'in person' Lee Silverman Voice Treatment (LSVT) and those treated remotely via iPad-based 'Facetime'. Method Eight participants were selected for the iPad LSVT, and 21 similarly matched subjects were selected from existing data to form the 'in person' group. Participants in both groups had diagnosed idiopathic Parkinson's disease and moderate hypokinetic dysarthria. Eighteen sessions of prescribed LSVT comprising a pre-treatment assessment, 16 treatment sessions, and a six months' post-treatment assessment were administered for each person. In both groups, pre- and post-treatment assessments were conducted face-to-face. Performance measures were recorded during assessment and treatment. Average measures were determined for all tasks at all time points and a summary outcome variable was composed from across-task performance. Results Non-inferiority testing confirmed that iPad LSVT was non-inferior in treating all LSVT task 3 variables except generating words, with the 90% upper confidence intervals (CI) lying between the non-inferiority margin of ± 2.25 and zero. The iPad was superior in treating the task 3 rainbow reading passage and describing motor task variables with upper and lower 90% CI values being negative. The improvement in the summary outcome variable score was also superior in the iPad group. Discussion Non-inferiority testing implies that the iPad LSVT is non-inferior in treating task three variables when compared to traditional LSVT. The study supports further development of remote delivery solutions involving the Apple iPad and 'Facetime' system as a means of improving access to services and the participant's experience.

Muusikalised jutustused

Index Scriptorium Estoniae

2008-01-01

Üritustest kontsertsarja Soul Spectrum raames Kumus: 14. märstsil Ursula Rucker (soojendusesinejad Riho Sibul, Jaak Sooäär ja Raul Saaremets), 15. märtsil folk-jazzlaulja Terry Callier (soojendusesinejad Tõnis Mägi ja Chalice)

Active aging through employment: a critical feminist perspective on Polish policy / Ania Zbyszewska

Index Scriptorium Estoniae

Zbyszewska, Ania

2016-01-01

Aktiivsest vananemisest, vanemaealiste tööhõivest. Üle 50-aastaste töötajate positsioonist tööjõuturul, soo ja teiste sotsiaalsete faktorite mõjust sellele. Poola aktiivse vananemise poliitikatest viimase 20 aasta jooksul

Eestimaa turismitöökoda MATKAMIKS 2004

Index Scriptorium Estoniae

2004-01-01

Turismiseminarist "Kultuur turismis. Turism kultuuris", kus turismist ja kultuurist rääkisid Riigikogu liige Imre Sooäär, EHRL juhatuse esimees Tarmo Sumberg, ajaloolane Lauri Vahtre, lavastaja Katri Kaasik-Aaslav ning Viljandi Kultuuriakadeemia rektor Anzori Barkalaja

CrossTalk: The Journal of Defense Software Engineering. Volume 21, Number 12

Science.gov (United States)

2008-12-01

IACROs Competitive Non- Competitive BAA: Broad Agency Announcement IACRO: Inter-Agency Cost Reimbursement Order MIPR: Military Interdepartmental...IACRO: Inter-Agency Cost Reimbur ement Order MIPR: Military Interdepartmental Purchas Request PWS: Performance Work Statement SOO: Stateme t of Objectives

Kas sugu on läbirääkimistel tähtis

Index Scriptorium Estoniae

2006-01-01

Ülevaade Harvard Business Schooli uudiskirja Working Knowledge 2006. aasta veebruari numbris ilmunud Dina W. Pradel'i, Hannah Riley Bowles'i ja Kathleen L. McGinn'i artiklist inimese soo mõjust läbirääkimistele

Kalopanacis Cortex extract-capped gold nanoparticles activate NRF2 signaling and ameliorate damage in human neuronal SH-SY5Y cells exposed to oxygen–glucose deprivation and reoxygenation

Directory of Open Access Journals (Sweden)

Park SY

2017-06-01

Full Text Available Sun Young Park,1 Seon Yeong Chae,1,2 Jin Oh Park,2 Kyu Jin Lee,2 Geuntae Park1,2 1Bio-IT Fusion Technology Research Institute, 2Department of Nanofusion Technology, Graduate School, Pusan National University, Busan, Republic of Korea Abstract: Recently, environment-friendly synthesis of gold nanoparticles (GNPs has been extensively explored by biologists and chemists. However, significant research is still required to determine whether “eco-friendly” GNPs are beneficial to human health and to elucidate the molecular mechanisms of their effects on human cells. We used human neuronal SH-SY5Y cells to show that treatment with Kalopanacis Cortex extract-capped GNPs (KC-GNs, prepared via an eco-friendly, fast, one-pot synthetic route, protected neuronal cells against oxygen–glucose deprivation/reoxygenation (OGD/R-induced damage. To prepare GNPs, Kalopanacis Cortex was used without any chemical reducing and stabilizing agents. Ultraviolet–visible spectroscopy showed maximum absorbance at 526 nm owing to KC-GN surface plasmon resonance. Hydrodynamic size (54.02±2.19 nm and zeta potential (-20.3±0.04 mV were determined by dynamic light scattering. The average diameter (41.07±3.05 nm was determined by high-resolution transmission electron microscopy. Energy-dispersive X-ray diffraction spectroscopy and X-ray diffraction confirmed the presence of assembled GNPs. Fourier transform infrared analysis suggested that functional groups such as O–H, C–C, and C–N participated in KC-GN formation. Cell viability assays indicated that KC-GNs restored the viability of OGD/R-treated SH-SY5Y cells. Flow cytometry demonstrated that KC-GNs inhibited the OGD/R-induced reactive oxygen species production and mitochondrial membrane potential disruption. KC-GNs also inhibited the apoptosis of OGD/R-exposed cells. Western blot analysis indicated that the OGD/R-induced cellular apoptosis and simultaneous increases in the expression of cleaved caspase-3, p

The Senses of Agency and Ownership: A Review.

Science.gov (United States)

Braun, Niclas; Debener, Stefan; Spychala, Nadine; Bongartz, Edith; Sörös, Peter; Müller, Helge H O; Philipsen, Alexandra

2018-01-01

Usually, we do not question that we possess a body and act upon the world. This pre-reflective awareness of being a bodily and agentive self can, however, be disrupted by different clinical conditions. Whereas sense of ownership (SoO) describes the feeling of mineness toward one's own body parts, feelings or thoughts, sense of agency (SoA) refers to the experience of initiating and controlling an action. Although SoA and SoO naturally coincide, both experiences can also be made in isolation. By using many different experimental paradigms, both experiences have been extensively studied over the last years. This review introduces both concepts, with a special focus also onto their interplay. First, current experimental paradigms, results and neurocognitive theories about both concepts will be presented and then their clinical and therapeutic relevance is discussed.

Improved oral absorption of cilostazol via sulfonate salt formation with mesylate and besylate

Directory of Open Access Journals (Sweden)

Seo JH

2015-07-01

Full Text Available Jae Hong Seo, Jung Bae Park, Woong-Kee Choi, Sunhwa Park, Yun Jin Sung, Euichaul Oh, Soo Kyung Bae College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon, South Korea Objective: Cilostazol is a Biopharmaceutical Classification System class II drug with low solubility and high permeability, so its oral absorption is variable and incomplete. The aim of this study was to prepare two sulfonate salts of cilostazol to increase the dissolution and hence the oral bioavailability of cilostazol.Methods: Cilostazol mesylate and cilostazol besylate were synthesized from cilostazol by acid addition reaction with methane sulfonic acid and benzene sulfonic acid, respectively. The salt preparations were characterized by nuclear magnetic resonance spectroscopy. The water contents, hygroscopicity, stress stability, and photostability of the two cilostazol salts were also determined. The dissolution profiles in various pH conditions and pharmacokinetic studies in rats were compared with those of cilostazol-free base.Results: The two cilostazol salts exhibited good physicochemical properties, such as nonhygroscopicity, stress stability, and photostability, which make it suitable for the preparation of pharmaceutical formulations. Both cilostazol mesylate and cilostazol besylate showed significantly improved dissolution rate and extent of drug release in the pH range 1.2–6.8 compared to the cilostazol-free base. In addition, after oral administration to rats, cilostazol mesylate and cilostazol besylate showed increases in Cmax and AUCt of approximately 3.65- and 2.87-fold and 3.88- and 2.94-fold, respectively, compared to cilostazol-free base.Conclusion: This study showed that two novel salts of cilostazol, such as cilostazol mesylate and cilostazol besylate, could be used to enhance its oral absorption. The findings warrant further preclinical and clinical studies on cilostazol mesylate and

Homme kell 13 algab Von Krahli teatris...

Index Scriptorium Estoniae

2005-01-01

III rahvusvaheline video ja performance'i festival "Inport 2005", mille on kokku pannud Gert Hatsukov. Loetletud aktsioonide autorid (Eesti: Sandra Jõgeva, Yellow Wolfman [Andrus Joonas], Andres Tenusaar)

'n Godsleer van Openbaring soos vervat in die himnes

Directory of Open Access Journals (Sweden)

E. Meyer

1997-07-01

Full Text Available A Theology of Revelations as imbedded in the hymns. This anicle is based on a twofold hypothesis, namely that the author of Revelation not only wrote the hymns in this book,' he also used them specifically to express his theology. The narrator utilises the hymnes to lay words in the mouths of the characters in order to establish a complete theology as well as christology. These hymns can even be used today to offer mankind real hope by calling one and all to the centre and true reason for our existence: Worship God!

Kutseõppeasutuste õpetajad = Pedagogues of vocational education institutions / Tiiu-Liisa Rummo

Index Scriptorium Estoniae

Rummo, Tiiu-Liisa

2007-01-01

Eesti lähituleviku eesmärgiks on motiveerida kutsehariduse pedagooge ja spetsialiste kutseharidussüsteemis töötama. Kutseõppeasutuste pedagoogid vanuserühma, soo, ametijärgu ja haridusastme järgi. Lisatud diagramm ja tabelid

Plaadiesitlus

Index Scriptorium Estoniae

2005-01-01

Heliplaatidest: Erdman/Sooäär" Peer Gynt & Other Stories" (esitlus 29. apr. Sakala keskuses), "Mi tango en Buenos Aires" (esitlus 24. apr. Sakala keskuses), Hinkus ja Maarja "Look Around" (esitlus 28. Rock Cafés grupiga Reel People)

A Different Kind of Web-Based Knowledge Management: The DTRA Acquisition ToolBook

Science.gov (United States)

2008-12-01

Reimbursement Order MIPR: Military Interdepartmental Purchase Request PWS: Performance Work Statement SOO: Statement of Objectives SOW: Scope of Work Figure 1...Competitive BAA: Broad Agency Announcement IACRO: Inter-Agency Cost Reimbur ement Order MIPR: Military Interdepartmental Purchas Request PWS

Association between vitamin D receptor polymorphisms and osteoporosis in patients with COPD

Directory of Open Access Journals (Sweden)

Kim SW

2015-09-01

Full Text Available Sei Won Kim,1 Jong Min Lee,1 Jick Hwan Ha,1 Hyeon Hui Kang,1 Chin Kook Rhee,1 Jin Woo Kim,1 Hwa Sik Moon,1 Ki Hyun Baek,2 Sang Haak Lee1 1Division of Pulmonology, Critical Care and Sleep Medicine, 2Division of Endocrinology and Metabolism, Department of Internal Medicine, St Paul’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Background: Patients with COPD are at an increased risk of osteoporosis. Although many studies have addressed the relationship between the vitamin D receptor (VDR polymorphisms and bone health, this relationship has not been fully investigated in patients with COPD. In this study, we investigated the association of VDR polymorphisms with bone mineral density (BMD and other clinical parameters in patients with COPD. Patients and methods: In total, 200 patients with COPD were included in this study. The VDR polymorphisms rs1544410 (A/G-BsmI, rs7975232 (A/C-ApaI, rs731236 (C/T-TaqI, and rs10735810 (C/T-FokI were determined by Sanger sequencing using blood DNA samples. BMD of the lumbar vertebra and the femoral neck was measured by dual-energy X-ray absorptiometry. Other clinical parameters were also evaluated. Haplotype and multivariate analyses were also performed. Results: Sex, body mass index, steroid use, percentage of forced expiratory volume in 1 second (FEV1, alkaline phosphatase, and 25-hydroxyvitamin D significantly influenced the risk of osteoporosis. Patients with osteoporosis were more likely to carry the rs7975232 C allele compared to normal patients with BMD. Haplotypes GCT and GAT were related to osteoporosis. Patients without the haplotype GAT allele showed a significantly lower T-score at the femoral neck and an increased risk of osteoporosis (odds ratio [OR]= 2.78, 95% confidence interval [CI]= 1.20–6.48, P=0.018 compared with carriers in the dominant model. Conclusion: Genetic variations in VDR are significantly associated with osteoporosis among patients with COPD

Preclinical pharmacokinetics, interspecies scaling, and pharmacokinetics of a Phase I clinical trial of TTAC-0001, a fully human monoclonal antibody against vascular endothelial growth factor 2

Directory of Open Access Journals (Sweden)

Lee WS

2018-03-01

Full Text Available Weon Sup Lee,1 Sang Ryeol Shim,1 Seon Young Lee,1 Jin San Yoo,1 Sung Kweon Cho2 1PharmAbcine, Inc., Daejeon, Republic of Korea; 2Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea Background: VEGF is a highly selective mitogen that serves as the central regulator of tumor angiogenesis by mediating endothelial proliferation, permeability, and survival. Tanibirumab (TTAC-0001 is a fully human IgG1 monoclonal antibody derived from a fully human naïve single-chain variable fragment (ScFv phage library that was developed to inhibit the effects of VEGF in the treatment of solid tumors, especially those of the brain. Methods: In the present study, we conducted intravenous pharmacokinetic studies of TTAC-0001 in mice, rats, and cynomolgus monkeys. At the doses studied (3 mg/kg, 10 mg/kg, 30 mg/kg, TTAC-0001 exhibited dose proportionality in mice and monkeys. At a dose of ~10 mg/kg, the clearance of TTAC-0001 from serum was 0.017 mL/h in mice, 0.35 mL/h in rats, and 2.19 mL/h in cynomolgus monkeys, and the terminal half-life ranged from 20–30 h among the three species. Pharmacokinetic data in mice, rats, and cynomolgus monkeys were used to predict the pharmacokinetics of TTAC-0001 in humans using allometric scaling. The predicted serum clearance of TTAC-0001 in humans was 102.45 mL/h and the terminal half-life was 27.52 h. Results: The maximum life span-corrected clearance value was 72.92 mL/h. The observed clearance in humans was more similar to the predicted scaled clearance. Conclusion: We investigated the pharmacokinetics of TTAC-0001 in mice, rats, and cynomolgus monkeys after intravenous administration. At the doses studied, TTAC-0001 exhibited dose proportionality in mice and monkeys. The scaled pharmacokinetics of TTAC-0001 reported here was useful for designing first-in-human studies. Allometric scaling in the therapeutic antibody is feasible. Keywords: VEGF2, tanibirumab, pharmacokinetics

Risk factors for chronic obstructive pulmonary disease among never-smokers in Korea

Directory of Open Access Journals (Sweden)

Lee SJ

2015-03-01

Full Text Available Seok Jeong Lee,1 Seo Woo Kim,1 Kyoung Ae Kong,2 Yon Ju Ryu,1 Jin Hwa Lee,1 Jung Hyun Chang1 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, 2Department of Clinical Trial Center, School of Medicine, Ewha Womans University, Seoul, Republic of Korea Background: Chronic obstructive pulmonary disease (COPD patients include those who have never smoked. However, risk factors other than smoking in never-smokers have not been elucidated sufficiently. This study investigated the risk factors for COPD among never-smokers in Korea using population-based data. Methods: The data were retrieved from the Korean National Health and Nutrition Survey IV conducted from 2007 to 2009. Among subjects aged 40 years or older who underwent appropriate pulmonary function tests, never-smokers not diagnosed with asthma and not showing a restrictive pattern on pulmonary function tests were enrolled. Risk factors of COPD in never-smokers were analyzed using logistic regression models. Results: Among 24,871 participants in the representative Korean cohort, 3,473 never-smokers were enrolled. COPD patients accounted for 7.6% of the never-smokers. In the logistic regression analysis, low education status (odds ratio [OR]: 2.0; 95% confidence interval [CI]: 1.2–3.2, occupational exposure (OR: 2.6; 95% CI: 1.3–5.3, a history of tuberculosis (OR: 4.5; 95% CI: 2.3–8.7, bronchiectasis (OR: 6.0; 95% CI: 1.4–25.4, male sex (OR: 4.2; 95% CI: 2.6–6.7, advanced age (60–69 years vs 40–49 years; OR: 3.8; 95% CI: 2.0–7.0, and being underweight (body mass index <18.5 vs 18.0–24.9 kg/m2; OR: 3.1; 95% CI: 1.0–9.4 were associated with the development of COPD. Conclusion: Low education status, manual labor, a history of tuberculosis and bronchiectasis, as well as male sex, advanced age and being underweight were risk factors for COPD in Korean never-smokers. Keywords: socioeconomic status, chronic obstructive pulmonary disease, never-smoker

Numerical experiments on plasma focus for soft x-ray yield scaling laws derivation using Lee model

International Nuclear Information System (INIS)

Akel, M.

2012-09-01

The required plasma parameters of krypton and xenon at different temperatures were calculated, the x-ray emission properties of plasmas were studied, and based on the corona model the suitable temperature range for generating H-like and He-like ions (therefore soft x-ray emissions) of different gases plasma were found. The code is applied to characterize the plasma focus in different plasma focus devices, and for optimizing the nitrogen, oxygen, neon, argon, krypton and xenon soft x-ray yields based on bank, tubes and operating parameters. It is found that the soft x-ray yield increases with changing pressure until it reaches the maximum value for each plasma focus device. Keeping the bank parameters, operational voltage unchanged but systematically changing other parameters, numerical experiments were performed finding the optimum combination of P o , Z o and 'a' for the maximum soft x-ray yield. Thus we expect to increase the soft x-ray yield of plasma focus device several-fold from its present typical operation; without changing the capacitor bank, merely by changing the electrode configuration and the operating pressure. The Lee model code was also used to run numerical experiments on plasma focus devices for optimizing soft x-ray yield with reducing L o , varying L o and 'a' to get engineering designs with maximum soft x-ray yield for these devices at different experimental conditions and gases. Numerical experiments showed the influence of the gas used in plasma focus and its properties on soft x-ray emission and its properties and then on its applications. Scaling laws for soft x-ray of nitrogen, oxygen, neon, argon, krypton and xenon plasma focus, in terms of energy, peak discharge current and focus pinch current were found. Radiative cooling effects are studied indicating that radiative collapse may be observed for heavy noble gases (Ar, Kr, Xe) for pinch currents even below 100 kA. The results show that the line radiation emission and tube voltages have

Numerical experiments on plasma focus for soft x-ray yield scaling laws derivation using Lee model

International Nuclear Information System (INIS)

Akel, M.

2015-01-01

The required plasma parameters of krypton and xenon at different temperatures were calculated, the x-ray emission properties of plasmas were studied, and based on the corona model the suitable temperature range for generating H-like and He-like ions (therefore soft x-ray emissions) of different gases plasma were found. The code is applied to characterize the plasma focus in different plasma focus devices, and for optimizing the nitrogen, oxygen, neon, argon, krypton and xenon soft x-ray yields based on bank, tubes and operating parameters. It is found that t he soft x-ray yield increases with changing pressure until it reaches the maximum value for each plasma focus device. Keeping the bank parameters, operational voltage unchanged but systematically changing other parameters, numerical experiments were performed finding the optimum combination of Po, z0 and 'a' for the maximum soft x-ray yield. Thus we expect to increase the soft x-ray yield of plasma focus device several-fold from its present typical operation; without changing the capacitor bank, merely by changing the electrode configuration and the operating pressure. The Lee model code was also used to run numerical experiments on plasma focus devices for optimizing soft x-ray yield with reducing Lo, varying z0 and 'a' to get engineering designs with maximum soft x-ray yield for these devices at different experimental conditions and gases. Numerical experiments showed the influence of the gas used in plasma focus and its propor ties on soft x-ray emission and its propor ties and then on its applications. Scaling laws for soft x-ray of nitrogen, oxygen, neon, argon, krypton and xenon plasma focus in terms of energy, peak discharge current and focus pinch current were found. Radiative cooling effects are studied indicating that radiative collapse may be observed for heavy noble gases (Ar, Kr, Xe) for pinch currents even below 100 k A. The results show that the line radiation emission and

Diurnal variability of inner-shelf circulation in the lee of a cape under upwelling conditions

Science.gov (United States)

Lamas, L.; Peliz, A.; Dias, J.; Oliveira, P. B.; Angélico, M. M.; Castro, J. J.; Fernandes, J. N.; Trindade, A.; Cruz, T.

2017-07-01

The nearshore circulation in the lee of a cape under upwelling conditions was studied using in-situ data from 3 consecutive summers (2006-2008). Focus was given to a period between 20 July and 04 August 2006 to study the diurnal variability of the cross-shelf circulation. This period was chosen because it had a steady upwelling-favourable wind condition modulated by a diurnal cycle much similar to sea breeze. The daily variability of the observed cross-shelf circulation consisted of three distinct periods: a morning period with a 3-layer vertical structure with onshore velocities at mid-depth, a mid-day period where the flow is reversed and has a 2-layer structure with onshore velocities at the surface and offshore flow below, and, lastly, in the evening, a 2-layer period with intensified offshore velocities at the surface and onshore flow at the bottom. The observed cross-shelf circulation showed a peculiar vertical shape and diurnal variability different from several other systems described in literature. We hypothesize that the flow reversal of the cross-shelf circulation results as a response to the rapid change of the wind magnitude and direction at mid-day with the presence of the cape north of the mooring site influencing this response. A numerical modelling experiment exclusively forced by winds simulated successfully most of the circulation at the ADCP site, especially the mid-day reversal and the evening's upwelling-type structure. This supports the hypothesis that the cross-shelf circulation at diurnal timescales is mostly wind-driven. By analysing the 3D circulation in the vicinity of Cape Sines we came to the conclusion that the diurnal variability of the wind and the flow interaction with topography are responsible for the circulation variability at the ADCP site, though only a small region in the south of the cape showed a similar diurnal variability. The fact that the wind diurnally undergoes relaxation and intensification strongly affects the

Elustiil = Lifestyle / Urve Kask

Index Scriptorium Estoniae

Kask, Urve

2006-01-01

Töö- ja pereaastatel on leibkonna jaoks oluline eelarve, mis annab ette kulutuste mahu. Naiste ja meeste leibkondade sissetuleku tase on erinev ja toob esile sugudevahelise tarbimisstruktuuri erinevuse. Leibkonnaliikmete tarbimisstruktuur leibkonnapea soo järgi. Lastega ja lasteta leibkondade tarbimisstruktuur. Diagrammid

DIE MlllTERE BOUKUNS IN DIE NEDER. (1500-1800)~

African Journals Online (AJOL)

aatkundige verhoudings van die Middcleeue en faktore soos navwer tus3cn verskillende stcd'C, wrywings -met landshere c.d.m. in aanmerking gc~eem word, dan kan hieruit afgelei word dat stedelike militere aangeleenthede. 'n belang- rikc plek ...

uie twe

African Journals Online (AJOL)

dictatorships began to disturb the balance of power in Europe. tn South Africa this gave rise to a new crJsis of divided loyalties, culminating in arguments about the country's ... met leiers soos Stalin, Hitler en Mussolini het Europese ...

Chlorine isotopic geochemistry of salt lakes in the Qaidam Basin, China

Digital Repository Service at National Institute of Oceanography (India)

Liu, W.G.; Xiao, Y.K.; Wang, Q.Z.; Qi, H.P.; Wang, Y.H.; Zhou, Y.M.; Shirodkar, P.V.

*Cl+ ion. Int. J. Mass Spectrom. Ion Process., 116: crysatallization of saline minerals in salt lake. J. Salt Lake 183-192. Sci., 2: 35-40 (in Chinese). Xiao, Y.K., Sun, D.P., Wang, Y.H., Qi, H.P. and Jin, L., 1992. Boron isotopic compositions of brine..., sediments, and source water in Da Qaidam Lake, Qinghai, China. Geochim. Cos- mochim. Acta, 56: 1.561-1568. Xiao, Y.K., Jin, L., Liu. W.G., Qi, H.P., Wang, W.H. and Sun, D.P., 1994a. The isotopic compositions of chlorine in Da Qaidam Lake. Chin. Sci...

Exposure to waterborne Cu inhibits cutaneous Na⁺ uptake in post-hatch larval rainbow trout (Oncorhynchus mykiss).

Science.gov (United States)

Zimmer, Alex M; Brauner, Colin J; Wood, Chris M

2014-05-01

In freshwater rainbow trout (Oncorhynchus mykiss), two common responses to acute waterborne copper (Cu) exposure are reductions in ammonia excretion and Na(+) uptake at the gills, with the latter representing the likely lethal mechanism of action for Cu in adult fish. Larval fish, however, lack a functional gill following hatch and rely predominantly on cutaneous exchange, yet represent the most Cu-sensitive life stage. It is not known if Cu toxicity in larval fish occurs via the skin or gills. The present study utilized divided chambers to assess cutaneous and branchial Cu toxicity over larval development, using disruptions in ammonia excretion (Jamm) and Na(+) uptake (Jin(Na)) as toxicological endpoints. Early in development (early; 3 days post-hatch; dph), approximately 95% of Jamm and 78% of Jin(Na) occurred cutaneously, while in the late developmental stage (late; 25 dph), the gills were the dominant site of exchange (83 and 87% of Jamm and Jin(Na), respectively). Exposure to 50 μg/l Cu led to a 49% inhibition of Jamm in the late developmental stage only, while in the early and middle developmental (mid; 17 dph) stages, Cu had no effect on Jamm. Jin(Na), however, was significantly inhibited by Cu exposure at the early (53% reduction) and late (47% reduction) stages. Inhibition at the early stage of development was mediated by a reduction in cutaneous uptake, representing the first evidence of cutaneous metal toxicity in an intact aquatic organism. The inhibitions of both Jamm and Jin(Na) in the late developmental stage occurred via a reduction in branchial exchange only. The differential responses of the skin and gills to Cu exposure suggest that the mechanisms of Jamm and Jin(Na) and/or Cu toxicity differ between these tissues. Exposure to 20μg/l Cu revealed that Jamm is the more Cu-sensitive process. The results presented here have important implications in predicting metal toxicity in larval fish. The Biotic Ligand Model (BLM) is currently used to predict

Vetshera estonskogo iskusstva / Ruta Pels

Index Scriptorium Estoniae

Pels, Ruta, 1960-

2001-01-01

Eesti kunsti õhtutest Suurbritannia saadiku residentsis Tallinnnas, partneriks La Galerie Passage. Iga kuu muutuvas kunstikollektsioonis olevatest eesti kunstnike töödest (Rein Tammik, Malle Leis, Sandra Jõgeva jt.)

77 FR 16249 - Notice of Cancellation of Customs Broker Licenses

Science.gov (United States)

2012-03-20

... Dependable International Services 12574 New Orleans. and Transport, Inc.. Professional Customs Brokers, Inc.... Horizon Logistics, LLC 28432 Dallas. Sandra L. Smith 15266 Dallas. Barry E. Booth 09627 San Francisco...

HIV ravi võtab peagi sadu miljoneid / Kadri Ibrus

Index Scriptorium Estoniae

Ibrus, Kadri

2007-01-01

HIV-positiivsete ravikulud on Eestis hüppeliselt kasvamas, kuna aastate eest nakatunud inimesed hakkavad nüüd vajama tõsist ravi. Lisaks diagrammid: Eestis levib HIV maailmas pea kõige kiiremini ; 2006. aastal nakatunud soo ja vanuse järgi

Eesti sigaretiturg 2005. aastal / E Ahermaa

Index Scriptorium Estoniae

Ahermaa, E

2006-01-01

Ülevaade Eesti sigaretiturul 2005. aastal aset leidnud muutustest. Tabelid: Suitsetajate osakaal soo järgi (% vastanutest); Sigarettide illegaalse kaubanduse maht ja arvestuslik maksutulukaotus. Diagrammid: Legaalsete ja illegaalsete sigarettide vahel valiku tegemine; Sigarettide hinna ja aktsiisi võrdlus Eestis 2005. ja 2009. aastal

Muusikast, muinsuskaitsest, keraamilistest lauanõudest ... : TPÜ kultuuriteaduskonna magistrantide ja doktorantide teaduskonverents 23. aprillil / Risto Paju

Index Scriptorium Estoniae

Paju, Risto

2001-01-01

Teaduskonverentsi juhatasid sisse K. Kirme, R. Pullat, H. Uibu. Ettekannetega esinesid T. Parktal, L. Suurmaa, M. Raabe, M. Loit, T. Soosõrv, M. Aarma, T. Tohver, R. Paju, O. Kozlova, A. Lõugas, M. Talvik, S. Sultson, P. Kängsep, A. Hrenova, J. Raihhelgauz

26 Resensie Barendse WEB 02.pmd

African Journals Online (AJOL)

Owner

roman/memoir/ bundel/tesis/geskrif”. Soos die titel beloof, is die boek chaoties. Ek gee daarom 'n kort op- somming van die verhaal in 'n poging om orde te skep binne die chaos: Die boek begin met die verteller wat vanuit 'n sielkundige.

Kolmapäeval kroonitakse Raekoja platsil Lucia

Index Scriptorium Estoniae

2006-01-01

Püha Lucia ehk luutsinapäeval kroonitakse heade jõulude kehastaja ja soojuse ning valguse tooja Lucia. Krooni valmistas Rootsi suursaatkonna algatatud konkursi võitja Sandra Savelli Eesti Kunstiakdeemiast

76 FR 8739 - Granting of Request for Early Termination of the Waiting Period Under the Premerger Notification...

Science.gov (United States)

2011-02-15

... Equity Investors V, L.P. 20110468 G New Generations Trust; Thomas and Dafna Kaplan; New Generations Trust... Corporation; Exxon Mobil Corporation; TSRC Corporation. FOR FURTHER INFORMATION CONTACT: Sandra M. Peay...

Plaadid / Immo Mihkelson

Index Scriptorium Estoniae

Mihkelson, Immo, 1959-

2002-01-01

Uutest plaatidest Mike Oldfield "Collection", Compay Segundo "Duets", Sandra "Wheel Of Time", "Spirit Of Africa", Paddy's "Irish Folk", Edwin Collins "Doctor Syntax", Doors "Live in Hollywood", Sonic Youth "Murray Street"

Pink Pungi näitusel valgub veri linale / Raimu Hanson

Index Scriptorium Estoniae

Hanson, Raimu, 1957-

2006-01-01

Kunstirühmituse Pink Punk (Sandra Jõgeva, Kristin Kalamees, Aino Ingrid Sepp, Kaarel Sammet) näitusest Y-galeriis. Lähemalt videoinstallatsioonist "Must turg" ja ruumiinstallatsioonist "Elulähedane kogemus"

Plaaslike bestuur en sy rol in fisiese beplanning

Directory of Open Access Journals (Sweden)

P. Z.J. van Vuuren

1965-03-01

Full Text Available Somaar uit die staanspoor wil ek verduidelik dat my bena- dering miskien vir sommige van u as te prakties en van te algemene aard mag voorkom en u moontlik sou verkies het dat ek meer moes uitwei oor die tegnieke en die beginsels van beplanning. Daardie aspekte laat ek egter aan die persone oor wat beter gekwalifiseer is om daaroor te praat as ek. Dit beteken egter nie dat ek, en ander soos ek, die aanvaarde en beproefde beginsels vir goeie beplanning kan ignoreer nie. Ek wil egter met hierdie inleidende woorde volstaan en dit aan u oordeel oorlaat om te besluit of u met hierdie bena- dering van my saamstem. Indien u nie met my saamstem nie, dan vertrou ek dat wat ek hier te sê het u minstens sal prikkel en u miskien sal aanspoor om die saak te stel soos u dit sien.