Jõgeva, Sandra, 1976-
IX rahvusvaheline graafikabiennaal "Kaliningrad-Königsberg 2008" Kaliningradi kunstigaleriis 15. IX-15. XI. Eesti väljapanek (kuraator Eha Komissarov, kujundaja Marko Nautras, osalejad: Jaanika Okk, Kaarel Kütas, Lauri Koppel, Gerda Märtens, Raul Meel, Lembe Ruben, HULA, Villem Jahu, Tiiu Pirsko, Mati Veermets, Sandra Jõgeva) sai ekspositsioonipreemia. Grand prix - Paulis Liepa, I preemia - Olrik Kohlhoff, II - Dominica Sadowska, III - Raffael Rheinsberg, eripreemia - Markus Lampinen
Jõgeva, Sandra, 1976-
Kunstnike grupp Art Container osales Brisbane'i teatrifestivalil (4.-25. sept. 2010) interaktiivse etenduse ja saunainstallatsiooniga "Kümblejad" (autorid Tanel Saar, Erik Alalooga, Sandra Jõgeva, Janno Bergmann, Hans-Gunter Lock)
Sandra Rieger studied at the University of Applied Sciences at Fulda, Germany, and wrote her diploma thesis in collaboration with Zyomyx, Inc. (San Francisco, USA). She then joined the laboratory of Reinhard Koester at the Helmholtz Center in Munich to complete her PhD in developmental neurobiology in 2008. For her postdoctoral studies, Sandra moved to the University of California, Los Angeles to work with Alvaro Sagasti on axon regeneration in zebrafish. Since 2011, she has been Assistant Professor for regenerative biology and medicine at the MDI Biological Laboratory in Maine, USA. In the summer of 2018, Sandra will establish a laboratory at the University of Miami, Florida, to become a tenure-track Associate Professor at the Department of Biology. The Rieger laboratory studies cellular communication mechanisms between sensory neurons and injured epidermal cells, leading to wound healing, nerve regeneration and degeneration after injury or exposure to chemotherapeutic agents. © 2018. Published by The Company of Biologists Ltd.
Ford, Bacon and Davis Utah Inc. has performed an engineering assessment of the problems resulting from the existence of radioactive residues from the burning of uranium-bearing lignite at Bowman, North Dakota. This engineering assessment has included the preparation of topographic maps, the performance of core drillings and radiometric measurements sufficient to determine areas and volumes of ash residues and radiation exposures of individuals and nearby populations, the investigations of site hydrology and meteorology, and the evaluation and costing of alternative corrective actions. Radon gas released from the 97,000 tons of ash and contaminated materials at the Bowman site constitutes a significant environmental impact, although windblown ash and external gamma radiation also are factors. The four alternative actions presented in this engineering assessment range from millsite decontamination with the addition of 3 m of stabilization cover material (Option I), to removal of the contaminated materials to remote disposal sites and decontamination of the ashing site (Options II through IV). Cost estimates for the four options range from about $1,740,000 for stabilization in-place, to about $3,060,000 for disposal at a distance of about 4 mi. Reprocessing the ash for uranium recovery is not feasible because of the extremely small amount of material available at the site and because of its low U 3 O 8 content
... : the world of art and the world of commerce; the country and the city; the heterosexual and the homosexual; world of society and the world of the stockman; the loner and the bon vivant. Sandra Mcgrath, who was ...
Non Grata Kunstikonteineris kuni 17. XI näitus "Dekonstruktsioon/Rekonstruktsioon", Orion Maxtedi ja Tanel Saare workshop'i jäädvustus. Workship'is osalesid performance'i-kunstnikud Beth Greenhalgh, Samuel Hasler, Yoko Ishiguro, maalikunstnik Josephine Wood, helikunstnik Simon Whetham ja Sandra Jõgeva
Breshears, Russell D.
Sandra Cisneros is giving a voice to farm workers, migrant workers, and Latinos living in the inner cities across the United States in poems and short stories that call attention to gender, class, and race issues that many would prefer to ignore. While her women protagonists challenge destructive "machismo," which takes the form of…
Jõgeva, Sandra, 1976-
Leedus Alytuse väikelinnas 20.-26.08.2007 toimunud eksperimentaalkunsti festivalist. II Alytuse biennaali korraldaja Mantas Kazakevicius, osalejad Inglismaalt, Tšehhist, Iirimaalt, Madalmaadest, Lätist, Leedust ja Eestist (Erik Alalooga, Ville Karel Viirelaid ja Sandra Jõgeva)
Hirsh, Elizabeth; Olson, Gary A.
Presents a conversation with philosopher of science Sandra Harding, a major exponent of "feminist standpoint theory." Argues that objectivity is maximized not by excluding social factors from the production of knowledge but by starting the process of inquiry from an explicitly social location--the lived experience of those traditionally…
Leis, Malle, 1940-
Intervjuu 9. juulil 70. sünnipäeva tähistanud maalikunstniku ja graafiku Malle Leisi ning tema tütre, kunstniku ja kirjaniku Sandra Jõgevaga. Kunstnikud endast, oma ja teineteise loomingust, huvist selle vastu, neid ühendavast, ideede taaskasutamisest, praegusest maalist, sotsiaalsest kunstist jm. Kunstnike eluloolisi andmeid ja andmeid nende loomingulise tegevuse kohta
Osborne, Jason W
D'Amico, Neilands, and Zambarano (2001) published SPSS syntax to perform power analyses for three complex procedures: ANCOVA, MANOVA, and repeated measures ANOVA. Unfortunately, the published SPSS syntax for performing the repeated measures analysis needed some minor revision in order to perform the analysis correctly. This article presents the corrected syntax that will successfully perform the repeated measures analysis and provides some guidance on modifying the syntax to customize the analysis.
Grant, Hugh, 1960-
Romantilises komöödias "Kaks nädalat armumiseks" ("Two Weeks Notice"), režissöör Marc Lawrence, mängivad kaks kuulsat näitlejat. Staarid oma suhetest : Hugh Grant : "Sandra on geenius"; Sandra Bullock : "Oleme temaga nagu kaksikud!"
Haensly, William E.; Lee, J.C.
Human kidney sections taken at autopsy were examined to determine the incidence of metaplasia of the Bowman's parietal epithelium. Autopsy records were consulted to determine if there was any correlation between clinical disease, histopathological changes in organ systems and metaplasia of Bowman's capsule. The sections represented both sexes in 9 age groups from 2 to 87 years. The sections were fixed in neutral formalin, embedded in paraffin, sectioned at 6 pm...
Jõgeva, Sandra, 1976-
Festivali kava üks koostajaid Sandra Jõgeva 24.-28. augustini 2011 toimuvast kultuuritehase Polymer festivalist ja tähtsamatest esinejatest. Selle aasta festivalil tegeldakse utoopiliste visioonidega
Luna-Antonio, Brenda I; Rodriguez-Muñoz, Rafael; Namorado-Tonix, Carmen; Vergara, Paula; Segovia, Jose; Reyes, Jose L
Gas1 (Growth Arrest-Specific 1) is a pleiotropic protein with novel functions including anti-proliferative and proapoptotic activities. In the kidney, the expression of Gas1 has been described in mesangial cells. In this study, we described that renal parietal cells of Bowman's capsule (BC) and the distal nephron cells also express Gas1. The role of Gas1 in the kidney is not yet known. There is a subpopulation of progenitor cells in Bowman's capsule with self-renewal properties which can eventually differentiate into podocytes as a possible mechanism of regeneration in the early stages of diabetic nephropathy. We analyzed the expression of Gas1 in the parietal cells of Bowman's capsule in murine experimental diabetes. We found that diabetes reduced the expression of Gas1 and increased the expression of progenitor markers like NCAM, CD24, and SIX1/2, and mesenchymal markers like PAX2 in the Bowman's capsule. We also analyzed the expression of WT1 (a podocyte-specific marker) on BC and observed an increase in the number of WT1 positive cells in diabetes. In contrast, nephrin, another podocyte-specific protein, decreases its expression in the first week of diabetes in the glomerular tuft, which is gradually restored during the second and third weeks of diabetes. These results suggest that in diabetes the decrease of Gas1 promotes the activation of parietal progenitor cells of Bowman's capsule that might differentiate into podocytes and compensate their loss observed in this pathology.
Sandra Postel, of the Worldwatch Institute, believes that inequalities in consumption and income foster environmental degradation. The richest 20% are getting richer and consuming excessively. The bottom 20%, comprising about 1 billion people, are getting poorer and are degrading their environment in order to survive. Per capita availability of resources is continually being reduced. If there is a desire to improve the quality of life for the poorest segment of the world population, then the richest must forfeit something. Environmental taxation could reduce excessive consumption in general; this strategy would be the most efficient and useful. Taxes would be placed on pollution and resources in danger of depletion; income taxes could be reduced to balance the impact of increased taxes on the economy. Wealthy countries must make a renewed commitment to poverty alleviation and to realistic sustainable development. Aid budgets should no longer reflect military priorities or strategic objectives. Trade is clearly related to the environment and poverty, and these connections must be made publicly known. National and international trade policies must deal with poverty issues and not contribute to further environmental destruction. Eliminating debt problems is another problem in need of change. The World Bank and structural adjustment policies have not proved to be environmentally sound and have not benefitted the poor. Evaluation of programs is needed, and lending policies should reflect the growing awareness of the problems of the poor and environmental consequences. Consumption of energy, wood, paper, and water are all higher among industrialized wealthy countries. Technology needs to be applied to maximize resource use, and policies must reflect this commitment. Israel has set a good example with water consumption reduction through advanced technology.
... Use of Aeronautical Property at Bowman Field Airport, Louisville, KY AGENCY: Federal Aviation... portion of airport property from aeronautical to non-aeronautical use at the Bowman Field Airport... under the provisions of Section 125 of the Wendell H. Ford Aviation Investment Reform Act for the 21st...
Johnson, Eldon C.
States that Bowman has identified a number of serious problems in our social and business environments and supports his adaptation of Maslow's model of human motivation as a communication theory and his interpretation of self-actualization beyond its popularized notion as simply a self-centered desire to develop one's own capabilities. (EL)
Bowman-Birk inhibitor (BBI) is toxic when fed to certain insects, including the fruit fly, Drosophila melanogaster. Dietary BBI has been demonstrated to slow growth and increase insect mortality by inhibiting the digestive enzymes trypsin and chymotrypsin, resulting in a reduced supply of amino acid...
Holderied, Alexander; Romoli, Simone; Eberhard, Jonathan; Konrad, Lukas A; Devarapu, Satish K; Marschner, Julian A; Müller, Susanna; Anders, Hans-Joachim
The metabolic and hemodynamic alterations in diabetes activate podocytes to increase extracellular matrix (ECM) production, leading to thickening of the glomerular basement membrane (GBM). We hypothesized that diabetes would activate parietal epithelial cells (PECs) in a similar manner and cause thickening of Bowman's capsules. Periodic acid Schiff staining of human kidney biopsies of 30 patients with diabetic nephropathy (DN) revealed a significantly thicker Bowman's capsule as compared with 20 non-diabetic controls. The average thickness was 4.55±0.21 μm in the group of patients with DN compared with 2.92±0.21 μm in the group of non-diabetic controls (PBowman's capsule showed strong association with CD44-positive PECs. In summary, metabolic alterations in diabetes activate PECs to increase the expression and secretion of Bowman's capsule proteins. This process may contribute to the thickening of the Bowman's capsule, similar to the thickening of the GBM that is driven by activated podocytes. These data may also imply that activated PECs contribute to ECM production once they migrate to the glomerular tuft, a process resulting in glomerular scaring, for example, in diabetic glomerulosclerosis.
Validation of the D'amico risk groups classification, valuation of high-risk patients with or without hormonal therapy and complications of patients with adenocarcinoma of the prostate, after treatment with external radiotherapy, Hospital Calderon Guardia, 2003-2004
Lopez Arias, Ever Roy
D'amico risk groups have been classified to estimate the probability of biochemical recurrence after treatment for localized prostate cancer. The evolution of patients that have received external radiotherapy were analyzed according to the risk group. The medical records of 50 patients between 2003 and 2004 have been assessed and has observed the evolution of Prostatic Specific Antigen after treatment ends, at Hospital Calderon Guardia. Adverse reactions resulting from radiotherapy treatment and the organs most affected by the same have been documented nith the possibility to compare the results of similar studies in the literature. The best performance is given by receiving concomitant hormonal therapy that high risk patients of D'amico without receiving. (author) [es
Library Journal, 2005
Sandra Tauler has tailored her collection and services to the needs of a community that is 97 percent Hispanic. Unfortunately, that's only half the job. The other half is getting potential users through the door. The solution Tauler and other Imperial Valley librarians came up with was Proyecto Televista. With LSTA funding, and the assistance of…
Jõgeva, Sandra, 1976-
Vilniuse II rahvusvaheline graafikabiennal "Present Time. Now Art Now Future" Vilniuse Kaasaegse Kunsti Keskuses kuni 11. V. Kuraatorid Ignas Kazakevicius ja Jurate Rekeviciute. Eestist osalevad Peeter Allik, Eve Kask ja Sandra Jõgeva. Kuraator Jurate Rekeviciute biennaali alanäitusest "Valmis ajalooks" Gediminase avenüü kaubanduskeskuse galeriis
Surface remedial action is scheduled to begin at the Belfield and Bowman Uranium Mill Tailings Remedial Action (UMTRA) Project sites in the spring of 1996. Water sampling was conducted in 1993 at both the Belfield processing site and the Bowman processing/disposal site. Results of the sampling at both sites indicate that ground water conditions have remained relatively stable over time. Water sampling activities are not scheduled for 1994 because ground water conditions at the two sites are relatively stable, the 1993 sampling was comprehensive, and surface remediation activities are not scheduled to start until 1996. The next water sampling event is scheduled before the start of remedial activities and will include sampling selected monitor wells at both sites and several domestic wells in the vicinity
Beranich, S.; Berger, N.; Bierley, D.; Bond, T.M.; Burt, C.; Caldwell, J.A.; Dery, V.A.; Dutcher, A.; Glover, W.A.; Heydenburg, R.J.; Larson, N.B.; Lindsey, G.; Longley, J.M.; Millard, J.B.; Miller, M.; Peel, R.C.; Persson-Reeves, C.H.; Titus, F.B.; Wagner, L.
The Uranium Mill Tailings Radiation Control Act of 1978 (UMTRCA), to clean up the Belfield and Bowman, North Dakota, uraniferous lignite processing sites to reduce the potential health impacts associated with the residual radioactive materials remaining at these sites. Remedial action at these sites must be performed in accordance with the US Environmental Protection Agency's (EPA) standards promulgated for the remedial action and with the concurrence of the US Nuclear Regulatory Commission (NRC) and the state of North Dakota. The inactive Belfield uraniferous lignite processing site is one mile southeast of Belfield, North Dakota. The inactive Bowman uraniferous lignite processing site at the former town of Griffin, is seven miles northwest of Bowman, North Dakota and 65 road miles south of Belfield. Lignite ash from the processing operations has contaminated the soils over the entire 10.7-acre designated Belfield site and the entire 12.1-acre designated Bowman site. Dispersion of the ash has contaminated an additional 20.6 acres surrounding the Belfield processing site and an additional 59.2 acres surrounding the Bowman processing site. The proposed remedial action is to relocate the contaminated materials at the Belfield processing site to the Bowman processing/disposal site for codisposal with the Bowman contaminated soils. The environmental impacts assessed in this EA were evaluated for the proposed remedial action and the no action alternative and demonstrate that the proposed action would not significantly affect the quality of the human environment and would be performed in compliance with applicable environmental laws. The no action alternative would not be consistent with the intent of Public Law 95-604 and would not comply with the EPA standards. 48 refs., 10 figs., 7 tabs
Haensly, W. E.; Granger, H. J.; Morris, A. C.; Cioffe, C.
Kidneys were samples from male spontaneously hypertensive rats (SHR) and normotensive rats (WKY) in four groups. Renal tissues were examined in 64 rats: 6 SHR and 6 WKY rats 8 and 16 weeks of age and 10 SHR and 10 WKY rats 32 and 64 weeks of age. Tissue samples were fixed, processed, and stained by routine histologic procedures. The parietal layer of Bowman's capsule in 100-115 renal corpuscles from right to left kidney sections was classified as squamous or cuboidal epithelium. The cuboidal ...
Full Text Available Deux visions des Andes vues par deux géographes, Isaiah BOWMAN et Carl TROLL, au caractère et au milieu intellectuel différents. L'auteur étudie dans l'un et l'autre cas la méthode d'analyse de l'espace géographique et les conclusions tirées par chacun d'eux. I. BOWMAN, Américain, convaincu qu'une économie mercantiliste fondée sur l'exportation permettra aux Etats andins d'accéder à un modèle de développement, décrit les vastes contrées amazoniennes comme un futur El Dorado entre les mains de colons. L'aménagement des basses plaines selon des schémas nord-américains est le pilier de l'économie alors que les Andes abritant les communautés indigènes constituent un frein au développement. De ce fait il laisse de côté l'étude des paysanneries andines. Toute différente est la démarche de Carl TROLL dont la formation à la fois en sciences humaines et naturelles, lui permet de cerner l'espace géographique comme cadre de vie des sociétés. L'utilisation des étages écologiques, le développement de l'Empire Inca fondé sur l'étage des 'punas', la démarche historique des analyses minutieuses de Carl TROLL donne un éclairage nouveau aux relations des sociétés andines et des milieux naturels avec lesquels elles composent. Dos puntos de vista de los Andes por dos geógrafos, Isaiah BOWMAN y Carl TROLL con carácter y medio intelectual distintos. El autor estudia en ambos casos el método de análisis del espacio geográfico y las conclusiones sacadas por cada uno de ellos. I. BOWMAN, americano, convencido que una economía mercantil fundada sobre la exportación permitirá a los estados andinos acceder a un modelo de desarrollo, describe las extensas llanuras amazónicas como un El Dorado futuro entre las manos de los colonos. El desarrollo de las llanuras bajas según esquemas norteamericanos constituye el pilar de la economía mientras los Andes abrigando las comunidades indígenas se comportan como un freno al
Matherly, S C; Hodges, S
Sandra C. Matherly, MA, RNC, FNP, is senior vice president, business development, and Shannon Hodges, MBA, is vice president, clinical development, Nurse On Call, Inc., Norcross, GA. Founded in 1993, Nurse on Call is a software and services company offering nursing, medical, and business expertise in setting up and operating a patient management unit using telecommunications and information systems. In this interview, Ms. Matherly and Ms. Hodges discuss the history and development of Nurse on Call, and offer advice for starting a successful nurse entrepreneur enterprise.
Tabatabai, Niloofar M; North, Paula E; Regner, Kevin R; Kumar, Suresh N; Duris, Christine B; Blodgett, Amy B
In kidney nephron, parietal epithelial cells line the Bowman's capsule and function as a permeability barrier for the glomerular filtrate. Bowman's capsule cells with proximal tubule epithelial morphology have been found. However, the effects of tubular metaplasia in Bowman's capsule on kidney function remain poorly understood. Sodium-glucose cotransporter 2 (SGLT2) plays a major role in reabsorption of glucose in the kidney and is expressed on brush border membrane (BBM) of epithelial cells in the early segment of the proximal tubule. We hypothesized that SGLT2 is expressed in tubularized Bowman's capsule and used our novel antibody to test this hypothesis. Immunohistochemical analysis was performed with our SGLT2 antibody on C57BL/6 mouse kidney prone to have tubularized Bowman's capsules. Cell membrane was examined with periodic acid-Schiff (PAS) stain. The results showed that SGLT2 was localized on BBM of the proximal tubules in young and adult mice. Bowman's capsules were lined mostly with normal brush border-less parietal epithelial cells in young mice, while they were almost completely covered with proximal tubule-like cells in adult mice. Regardless of age, SGLT2 was expressed on BBM of the tubularized Bowman's capsule but did not co-localize with nephrin in the glomerulus. SGLT2-expressing tubular cells expanded from the urinary pole toward the vascular pole of the Bowman's capsule. This study identified the localization of SGLT2 in the Bowman's capsule. Bowman's capsules with tubular metaplasia may acquire roles in reabsorption of filtered glucose and sodium.
The goal of the Uranium Mill Tailings Remedial Action (UMTRA) Project in North Dakota is to improve the environment and reduce the negative health effects associated with residual radioactive material (RRM) from the inactive processing sites at Belfield and Bowman, North Dakota. A secondary benefit of the UMTRA Project is economic gain. The 1992 North Dakota Economic Impact Study (NDEIS) analyzes the impact of the remedial actions at the inactive Belfield and Bowman processing sites and their associated vicinity properties. This analysis is based on the assumption that the state of North Dakota will provide 10 percent of the funding required for remediation. For every dollar the state of North Dakota invests in the Belfield and Bowman onsite portion of the UMTRA Project, it will realize $5.04 in gross labor income (i.e., gross labor income divided by the state's total funding requirement). For every dollar the state of North Dakota invests, it will realize a net return of $3.04 (i.e., net benefit divided by the state's total funding requirement). This reflects only labor expenditure and employment impact. ff state and local non-labor tax benefits were considered in the net economic benefit, North Dakota could receive significantly more than $3.04 for each dollar it invests. The UMTRA Project work at Belfield and Bowman will benefit the state of North Dakota. Benefits include a reduction in the negative health effects caused by low-level RRM, an improvement in the environment, and increased economic growth
Vestlus ameerika bioloogi ja ise vähki põdenud Sandra Steingraberiga vähivastasest võitlusest. S. Steingraberil on ilmunud ka mitu raamatut, nendest "Having faith" on tõlgitud ka eesti keelde (Mina olen ookean. Tartu : Petrone Print, 2009)
Haensly, William E.
This report is the second of two surveys to determine the incidence of metaplasia of Bowman's parietal epithelium in the human kidney. Human kidney sections obtained at autopsy at the Department of Pathology, University of Texas Medical Branch, Galveston, Texas, were examined with the light microscope. The kidneys were fixed in neutral formalin, sectioned at 6 pm and stained with hematoxylin and eosin. Autopsy records were consulted after kidney section exa...
This baseline risk assessment of ground water contamination at the inactive uraniferous lignite ashing site near Bowman, North Dakota, evaluates the potential impacts to public health or the environment from contaminated ground water at this site. This contamination is a result of the uraniferous lignite ashing process, when coal containing uranium was burned to produce uranium. Potential risk is quantified only for constituents introduced by the processing activities and not for the constituents naturally occurring in background ground water in the site vicinity. Background ground water, separate from any site-related contamination, imposes a percentage of the overall risk from ground water ingestion in the Bowman site vicinity. The US Department of Energy (DOE) Uranium Mill Tailings Remedial Action (UMTRA) Project is developing plans to address soil and ground water contamination at the site. The UMTRA Surface Project involves the determination of the extent of soil contamination and design of an engineered disposal cell for long-term storage of contaminated materials. The UMTRA Ground Water Project evaluates ground water contamination. Based on results from future site monitoring activities as defined in the site observational work plan and results from this risk assessment, the DOE will propose an approach for managing contaminated ground water at the Bowman site
This baseline risk assessment of ground water contamination at the inactive uraniferous lignite ashing site near Bowman, North Dakota, evaluates the potential impacts to public health or the environment from contaminated ground water at this site. This contamination is a result of the uraniferous lignite ashing process, when coal containing uranium was burned to produce uranium. Potential risk is quantified only for constituents introduced by the processing activities and not for the constituents naturally occurring in background ground water in the site vicinity. Background ground water, separate from any site-related contamination, imposes a percentage of the overall risk from ground water ingestion in the Bowman site vicinity. The US Department of Energy (DOE) Uranium Mill Tailings Remedial Action (UMTRA) Project is developing plans to address soil and ground water contamination at the site. The UMTRA Surface Project involves the determination of the extent of soil contamination and design of an engineered disposal cell for long-term storage of contaminated materials. The UMTRA Ground Water Project evaluates ground water contamination. Based on results from future site monitoring activities as defined in the site observational work plan and results from this risk assessment, the DOE will propose an approach for managing contaminated ground water at the Bowman site.
The Uranium Mill Tailings Radiation Control Act (UMTRCA) of 1978 authorized the US Department of Energy (DOE) to perform remedial actions at Belfield and Bowman inactive lignite ashing sites in southwestern North Dakota to reduce the potential public health impacts from the residual radioactivity remaining at the sites. The US Environmental Protection Agency (EPA) promulgated standards (40 CFR 192) that contain measures to control the residual radioactive materials and other contaminated materials, and proposed standards to protect the groundwater from further degradation. Remedial action at the Belfield and Bowman sites must be performed in accordance with these standards and with the concurrence of the US Nuclear Regulatory Commission (NRC) and the state of North Dakota. The Belfield and Bowman designated sites were used by Union Carbide and Kerr-McGee, respectively, to process uraniferous lignite in the 1960s. Uranium-rich ash from rotary kiln processing of the lignite was loaded into rail cars and transported to uranium mills in Rifle, Colorado, and Ambrosia Lake, New Mexico, respectively. As a result of the ashing process, there is a total of 158,400 cubic yards (yd 3 ) [121,100 cubic meters (m 3 )] of radioactive ash-contaminated soils at the two sites. Windblown ash-contaminated soil covers an additional 21 acres (8.5 ha) around the site, which includes grazing land, wetlands, and a wooded habitat
Sagrinati, Costanza; Netti, Giuseppe Stefano; Mazzinghi, Benedetta; Lazzeri, Elena; Liotta, Francesco; Frosali, Francesca; Ronconi, Elisa; Meini, Claudia; Gacci, Mauro; Squecco, Roberta; Carini, Marco; Gesualdo, Loreto; Francini, Fabio; Maggi, Enrico; Annunziato, Francesco; Lasagni, Laura; Serio, Mario; Romagnani, Sergio; Romagnani, Paola
Regenerative medicine represents a critical clinical goal for patients with ESRD, but the identification of renal adult multipotent progenitor cells has remained elusive. It is demonstrated that in human adult kidneys, a subset of parietal epithelial cells (PEC) in the Bowman's capsule exhibit coexpression of the stem cell markers CD24 and CD133 and of the stem cell-specific transcription factors Oct-4 and BmI-1, in the absence of lineage-specific markers. This CD24+CD133+ PEC population, which could be purified from cultured capsulated glomeruli, revealed self-renewal potential and a high cloning efficiency. Under appropriate culture conditions, individual clones of CD24+CD133+ PEC could be induced to generate mature, functional, tubular cells with phenotypic features of proximal and/or distal tubules, osteogenic cells, adipocytes, and cells that exhibited phenotypic and functional features of neuronal cells. The injection of CD24+CD133+ PEC but not of CD24-CD133- renal cells into SCID mice that had acute renal failure resulted in the regeneration of tubular structures of different portions of the nephron. More important, treatment of acute renal failure with CD24+CD133+ PEC significantly ameliorated the morphologic and functional kidney damage. This study demonstrates the existence and provides the characterization of a population of resident multipotent progenitor cells in adult human glomeruli, potentially opening new avenues for the development of regenerative medicine in patients who have renal diseases.
Gallan, Alexander J; Chon, W James; Josephson, Michelle A; Cunningham, Patrick N; Henriksen, Kammi J; Chang, Anthony
Acute T cell-mediated rejection (TCMR) is an important cause of renal allograft loss. The Banff classification for tubulointerstitial (type I) rejection is based on the extent of both interstitial inflammation and tubulitis. Lymphocytes may also be present between parietal epithelial cells and Bowman capsules in this setting, which we have termed "capsulitis." We conducted this study to determine the clinical significance of capsulitis. We identified 42 patients from the pathology archives at the University of Chicago with isolated Banff type I TCMR from 2010-2015. Patient demographic data, Banff classification, and graft outcome measurements were compared between capsulitis and non-capsulitis groups using Mann-Whitney U test. Capsulitis was present in 26 (62%), and was more frequently seen in Banff IB than IA TCMR (88% vs 44%, P=.01). Patients with capsulitis had a higher serum creatinine at biopsy (4.6 vs 2.9mg/dL, P=.04) and were more likely to progress to dialysis (42% vs 13%, P=.06) with fewer recovering their baseline serum creatinine (12% vs 38%, P=.08). Patients with both Banff IA TCMR and capsulitis have clinical outcomes similar or possibly worse than Banff IB TCMR compared to those with Banff IA and an absence of capsulitis. Capsulitis is an important pathologic parameter in the evaluation of kidney transplant biopsies with potential diagnostic, prognostic, and therapeutic implications in the setting of TCMR. Copyright © 2018. Published by Elsevier Inc.
Full Text Available Abstract Background Lipopolysaccharide (LPS, the major component of the outer membrane of gram-negative bacteria, can activate immune cells including macrophages. Activation of macrophages in the central nervous system (CNS contributes to neuronal injury. Bowman-Birk inhibitor (BBI, a soybean-derived protease inhibitor, has anti-inflammatory properties. In this study, we examined whether BBI has the ability to inhibit LPS-mediated macrophage activation, reducing the release of pro-inflammatory cytokines and subsequent neurotoxicity in primary cortical neural cultures. Methods Mixed cortical neural cultures from rat were used as target cells for testing neurotoxicity induced by LPS-treated macrophage supernatant. Neuronal survival was measured using a cell-based ELISA method for expression of the neuronal marker MAP-2. Intracellular reactive oxygen species (ROS production in macrophages was measured via 2', 7'-dichlorofluorescin diacetate (DCFH2DA oxidation. Cytokine expression was determined by quantitative real-time PCR. Results LPS treatment of macrophages induced expression of proinflammatory cytokines (IL-1β, IL-6 and TNF-α and of ROS. In contrast, BBI pretreatment (1-100 μg/ml of macrophages significantly inhibited LPS-mediated induction of these cytokines and ROS. Further, supernatant from BBI-pretreated and LPS-activated macrophage cultures was found to be less cytotoxic to neurons than that from non-BBI-pretreated and LPS-activated macrophage cultures. BBI, when directly added to the neuronal cultures (1-100 μg/ml, had no protective effect on neurons with or without LPS-activated macrophage supernatant treatment. In addition, BBI (100 μg/ml had no effect on N-methyl-D-aspartic acid (NMDA-mediated neurotoxicity. Conclusions These findings demonstrate that BBI, through its anti-inflammatory properties, protects neurons from neurotoxicity mediated by activated macrophages.
Dian Natalia Sutanto
Full Text Available La Malinche, the mistress of Spanish conquistador Hernán Cortés, has evolved from a historical figure into Mexican national myth that connotes all the negative aspects of woman’s sexuality in Mexican and Mexican-American Culture. Sandra Cisneros in her Never Marry A Mexican reinterpretsLa Malinchein a more positive light and points out how women sexuality can be the site for women empowerment.By drawing on insights from feminist theories on motherhood, marriage, and incest taboo, this study identifies the way Cisneros revises the negative image of La Malinche as a dupe, passive and submissive mistress. This study identifies that Cisneros has created a strong protagonist character named Clemencia, who exerts her subjectivity and claims for her sexual agency totransgress patriarchal construction of woman passive sexuality, imposition of maternal identity as asexual mother and taboo on incestuous relationship. Cisneros’s La Malinche is no longer depicted as the victim duped by the patriarchy, but as the survivor who is able to preserve her sense of herself in the dominating patriarchal world. DOI: https://doi.org/10.24071/llt.2015.180103
Elizabeth Escalona Leyva
Full Text Available El propósito en este trabajo es evaluar la electrocauterización de la membrana de Bowman como alternativa quirúrgica en el tratamiento de la queratopatía bullosa dolorosa. Se estudiaron 30 ojos de 30 pacientes con diagnóstico de queratopatía bullosa dolorosa que no habían logrado mejoría con los tratamientos habituales. Se tomaron como variables fundamentales la edad, el sexo, la etiología, el tiempo de evolución, la epitelización, las complicaciones y el alivio sintomático, los datos se tabularon de forma manual teniendo en cuenta el universo de pacientes. Predominó la queratopatía bullosa posquirúrgica (afáquicas y pseudofáquicas en el 83,3 % de los pacientes. Las edades más afectadas fueron los mayores de 60 años (63,3 %; no se encontraron diferencias significativas en cuanto al sexo. El tiempo de epitelización fue de 7 a 14 días en el 93,3 % de los pacientes y solo se encontraron complicaciones en el 14 % que no fueron de gravedad. El alivio de los síntomas se produjo en el 66,6 % en la primera semana del posoperatorio. La electrocauterización de la membrana de Bowman constituye un método eficaz, sencillo y con resultados satisfactorios en el tratamiento de la queratopatía bullosa dolorosaThe purpose of this paper is to evaluate the electrocauterization of Bowman's membrane as a surgical alternative in the treatment of painful bullous keratopathy. 30 eyes from 30 patients who were diagnosed painful bullous keratopathy and had not improved with the habitual treatments were studied. Age, sex, ethiology, time of evolution, epithelialization, complications and the symptomatic relief were taken as fundamental variables. Data were manually tabulated, taking into account the number of patients. The psotsurgical bullous keratopathy (aphakic y pseudophakic prevailed in 83.3 % of the patients. The most affected were those over 60 (63.3 %. No significant differences were found in relation to sex. The time of epithelialization
José E. García
Full Text Available En 1987 los psicólogos estadounidenses James O. Whittaker y Sandra J. Whittaker publicaron la cuarta edición de su famoso libro Psicología. Este fue uno de los textos de introducción más conocidos y utilizados en América Latina y a través de él muchos miles de estudiantes aprendieron sus primeros conceptos sobre la psicología. Esta edición estaba preparada especialmente para su utilización con los alumnos de habla castellana e introducía numerosos tópicos relacionados a la psicología latinoamericana. Además incluía menciones específicas a algunos psicólogos de la región y sus contribuciones a la psicología. Uno de ellos era José de Jesús Aguirre, psicólogo y sacerdote jesuita y uno de los pioneros de la psicología profesional en el Paraguay. Aguirre aplicó la teoría del filósofo holandés Gerard Heymans y su colaborador el psiquiatra Enno Dirk Wiersma con las modificaciones que unos años más tarde introdujo el psicólogo francés René Le Senne. El propósito de la investigación era el análisis de los rasgos tipológicos característicos en la población paraguaya. Con ello, Aguirre iniciaba el estudio científico de la personalidad en el Paraguay. Este artículo estudia la importancia que corresponde asignar a la investigación de Aguirre como parte del texto introductorio de Whittaker y Whittaker. Se analizan los fundamentos teóricos de la tipología de Heymans-Wiersma-Le Senne y las adaptaciones realizadas por Aguirre, además de su aplicación a una muestra superior a las setecientas personas. Esta provenía de diversos niveles educativos, tanto secundarios como universitarios. En la parte concluyente se analiza la relevancia de Aguirre y su trabajo en el contexto de la psicología paraguaya y latinoamericana.
This paper presents the first study describing the isolation, cloning and characterization of a full length gene encoding Bowman-Birk protease inhibitor (RbTI) from rice bean (Vigna umbellata). A full-length protease inhibitor gene with complete open reading frame of 327bp encoding 109 amino acids w...
This remedial action plan (RAP) has been developed to serve a threefold purpose. It presents the series of activities that are proposed by the US Department of Energy (DOE) to accomplish long-term stabilization and control of radioactive materials at the inactive uraniferous lignite processing sites at Belfield and near Bowman (at the former Griffin town site), North Dakota. It provides a characterization of the present conditions of the sites. It also serves to document the concurrence of the state of North Dakota and the US Nuclear Regulatory Commission (NRC) in the remedial action. This agreement, upon execution by the DOE and the state of North Dakota and concurrence by the NRC, becomes Appendix B of the Cooperative Agreement
Full Text Available La publication de L’Homosexualité féminine dans l’Antiquité grecque et romaine de Sandra Boehringer est, à plusieurs titres, une excellente nouvelle.Sur le plan universitaire et éditorial, d’abord, ce livre vient confirmer qu’après de longues années de chape de plomb, les départements de lettres classiques et d’histoire ancienne sont en train de s’ouvrir aux recherches sur la sexualité. L’université française ne s’est mise – c’est le moins que l’on puisse dire – que très lentement aux recherc...
Fischer, Edgar G; Carney, J Aidan; Anderson, Scott R; Klatt, Edward C; Lager, Donna J
Metanephric metaplasia of the parietal epithelium of the Bowman capsule is a rare pathologic finding of unknown pathogenesis that has occurred in patients with widespread malignant neoplasms of various types. We report this finding in a 25-year-old woman with partial expression of the Carney triad who died of a disseminated gastrointestinal stromal tumor, specifically a gastric stromal sarcoma. The metaplasia involved both kidneys diffusely. It originated in the parietal epithelium of the Bowman capsule, extended into the proximal tubules, and focally surrounded the glomeruli in a semicircular manner Immunohistochemical analysis revealed that the cells of metanephric metaplasia expressed the Wilms tumor gene product, bcl-2 protein, and CD57 and cytokeratin 7 and keratin AE1/AE3 focally, but not CD56. This immunophenotype parallels that of metanephric adenoma, Wilms tumor, and nephrogenic rests and overlaps with antigen expression in certain periods of renal development.
The Belfield and Bowman sites were not included on the original congressional list of processing sites to be designated by the Secretary of Energy. Instead, the sites were nominated for designation by the Dakota Resource Council in a letter to the DOE (September 7, 1979). In a letter to the DOE (September 12, 1979), the state of North Dakota said that it did not believe the sites would qualify as processing sites under the Uranium Mill Tailings Radiation Control Act (UMTRCA) because the activities at the sites involved only the ashing of uraniferous lignite coal and the ash was shipped out of state for actual processing. Nevertheless, on October 11, 1979, the state of North Dakota agreed to the designation of the sites because they met the spirit of the law (reduce public exposure to radiation resulting from past uranium operations). Therefore, these sites were designated by the Secretary of Energy for remedial action. Because of the relatively low health impacts determined for these sites, they were ranked as low priority and scheduled to be included in the final group of sites to be remediated.
Fine, Leon G
Charles Edward Isaacs (1811-1860), an anatomist working in New York, undertook a series of studies which attempted to define the microscopic structure of the nephrons in a variety of species. Given that he published his findings 15 years after William Bowman's seminal paper on the subject, he was able to add only a few of the finer details to the picture. He observed the continuity of the epithelium of the glomerular capsule with that of the proximal tubule and he demonstrated that the glomerular tuft is covered by a layer of epithelial cells. In a series of studies on human renal function he erroneously concluded that the glomerulus must have an excretory function in addition to its filtration function and that diuretics act primarily on the glomerlus. The latter conclusion was based upon observations of substances not currently categorized as being diuretic agents. The absence of a major conceptual advance in the writings of Isaacs probably accounts for that fact that his contribution has been largely forgotten.
The Belfield and Bowman sites were not included on the original congressional list of processing sites to be designated by the Secretary of Energy. Instead, the sites were nominated for designation by the Dakota Resource Council in a letter to the DOE (September 7, 1979). In a letter to the DOE (September 12, 1979), the state of North Dakota said that it did not believe the sites would qualify as processing sites under the Uranium Mill Tailings Radiation Control Act (UMTRCA) because the activities at the sites involved only the ashing of uraniferous lignite coal and the ash was shipped out of state for actual processing. Nevertheless, on October 11, 1979, the state of North Dakota agreed to the designation of the sites because they met the spirit of the law (reduce public exposure to radiation resulting from past uranium operations). Therefore, these sites were designated by the Secretary of Energy for remedial action. Because of the relatively low health impacts determined for these sites, they were ranked as low priority and scheduled to be included in the final group of sites to be remediated
Full Text Available Reseña bibliográfica del libro de Sandra Szir (coord., Ilustrar e imprimir. Una historia de la cultura gráfica en Buenos Aires, 1830-1930, Buenos Aires, Ampersand, 2016, 298 pp. Ilustrar e imprimir. Una historia de la cultura gráfica en Buenos Aires, 1830-1930 reúne a un grupo de investigadores coordinados por Sandra Szir. Se toman diferentes objetos de estudio relacionados con el diseño gráfico y se los analizan en función de la disciplina correspondiente pero también relacionados con el contexto histórico en el cual se enmarcan.
Slade, Stephen G; Durrie, Daniel S; Binder, Perry S
To determine the differences in the visual results, pain response, biomechanical effect, quality of vision, and higher-order aberrations, among other parameters, in eyes undergoing either photorefractive keratectomy (PRK) or thin-flap LASIK/sub-Bowman keratomileusis (SBK; intended flap thickness of +/-100 microm and 8.5-mm diameter) at 1, 3, and 6 months after surgery. A contralateral eye pilot study. Fifty patients (100 eyes) were enrolled at 2 sites. The mean preoperative spherical refraction was -3.66 diopters (D) and the mean cylinder was -0.66 D for all eyes. Eyes in the PRK group underwent 8.5-mm ethanol-assisted PRK, whereas in eyes in the SBK group, an 8.5-mm, (intended) 100-microm flap was created with a 60-kHz IntraLase femtosecond laser (Advanced Medical Optics, Santa Ana, CA). All eyes underwent a customized laser ablation using an Alcon LADARVision 4000 CustomCornea excimer laser (Alcon Laboratories, Fort Worth, TX). Preoperative and postoperative tests included best spectacle-corrected visual acuity, uncorrected visual acuity (UCVA), corneal topography, wavefront aberrometry, retinal image quality, and contrast sensitivity. Patients completed subjective questionnaires at each visit. One- and 3-month UCVA results showed a statistically significant difference: SBK, 88% 20/20 or better vs. 48% 20/20 or better for PRK. At 6 months, UCVA was 94% 20/20 or better for PRK and 92% for SBK. At 1 and 3 months, the SBK group had lower higher-order aberrations (coma and spherical aberration; PPRK group. By 3 months, the vision in the 2 groups had begun to equalize, although the SBK eyes continued to have better vision. At 6 months, there were no statistical differences between the 2 groups. Proprietary or commercial disclosure may be found after the references.
Price, Samuel J; Pangloli, Philipus; Krishnan, Hari B; Dia, Vermont P
Soybean contains several biologically active components and one of this belongs to the bioactive peptide group. The objectives of this study were to produce different lunasin-enriched preparations (LEP) and determine the effect of Bowman-Birk inhibitor (BBI) and Kunitz trypsin inhibitor (KTI) concentrations on the stability of lunasin against pepsin-pancreatin hydrolysis (PPH). In addition, the effect of KTI mutation on lunasin stability against PPH was determined. LEP were produced by calcium and pH precipitation methods of 30% aqueous ethanol extract from defatted soybean flour. LEP, lunasin-enriched commercially available products and KTI control and mutant flours underwent PPH and samples were taken after pepsin and pepsin-pancreatin hydrolysis. The concentrations of BBI, KTI, and lunasin all decreased after hydrolysis, but they had varying results. BBI concentration ranged from 167.5 to 655.8μg/g pre-hydrolysis and 171.5 to 250.1μg/g after hydrolysis. KTI concentrations ranged from 0.3 to 122.3μg/g pre-hydrolysis and 9.0 to 18.7μg/g after hydrolysis. Lunasin concentrations ranged from 8.5 to 71.0μg/g pre-hydrolysis and 4.0 to 13.2μg/g after hydrolysis. In all products tested, lunasin concentration after PPH significantly correlated with BBI and KTI concentrations. Mutation in two KTI isoforms led to a lower concentration of lunasin after PPH. This is the first report on the potential role of KTI in lunasin stability against PPH and must be considered in designing lunasin-enriched products that could potentially survive digestion after oral ingestion. Copyright © 2016 Elsevier Ltd. All rights reserved.
Full Text Available “The people I wrote about were real, for the most part, from here and there, now and then, but sometimes three real people would be braided together into one made-up person… I cut apart and stitched together events to tailor the story, gave it shape so it had a beginning, middle, and end, because real life stories rarely come to us complete. Emotions, though, can’t be invented, can’t be borrowed. All the emotions my characters feel, good or bad are mine.” (xxiii Although Sandra Cisneros draws on autobiographical elements in The House on Mango Street (1984, her novella does not stand for an autobiography, but it rather represents a collage of events, characters, and places that independently from one another constitute vignettes. These vignettes are not necessarily chronologically related, yet they make up a whole of voices, stories, colors, and movements that once reverberated along Mango Street. Through her (Cisneros’s stories, Esperanza Cordero’s stories, and Esperanza’s neighbors’ stories, Cisneros conveys the Southwestern Latino experience of the big city and the streets, of the barrios that is. Taking my cue from Cisneros’s “The House on Mango Street,” I will try to examine how personal experiences become memories and those memories transcend into stories. Is what comes from experience and memory that makes writing strong, powerful, persuasive, and to a certain extent relatable? Have Cisneros’s memories, reflected in Esperanza’s living experience and language contributed to the Latino’s collective memory of the life in the barrios coupled with racism, poverty and shame? On that note, I shall see how Maurice Halbwachs’s concept of collective memory applies to Cisneros’ story and the Latino experience, where Latinos’ memory is dependent upon the life in the barrio within which the majority were/are situated.
Luis fernando Gómez R
This paper discusses the short story ‘El arroyo de la Llorona’ by female Mexican-American writer Sandra Cisneros. In it the main character, Cleófilas, is subject to social, emotional and economic dependence on her husband, according to the cultural constructs on female identity that are still relevant in Latin-American patriarchal societies. Due to her circumstances of complete marginalisation and domestic violence, Cleófilas chooses to avoid reality, and this avoidance not only costs her men...
18.-22. okt. Pärnu teatris Endla toimunud rahvusvahelisest laste- ja noorteteatrite festivalist "NB festival 2008". Pikemalt lavastustest "Võimaluste aed" (Prantsuse teatritrupp Association 16 rue de Plaisance), "Sailor & Pekka" (Rootsi teater TRE), "Misantroop" (VAT-teater), "Maria Bonita" (Taani teater Batida), "Avatud ring" (Leedu teatrilabor Open Circle)
Jõgeva, Sandra, 1976-
Eesti kunstnike väljapanekust "Empty Spaces and their Occupants" 12.-24. augustini 2006 a. toimuval Peterburi Maneezhi 6. rahvusvahelisel eksperimentaalkunsti festivalil, kuraator Maksim Surin. Osalevad Kaido Ole, Merike Estna, Meeland Sepp jt
Anuradha, Ravi; Raveendran, Muthuraj; Babu, Subramanian
The interaction between the clinical isolate of enteropathogenic Escherichia coli (EPEC) SBANU8 and pea sprouts was compared with avirulent K 12. E. coli. This was carried out by repeated co-incubation with pea sprouts for 5 days, and the protein profile of the culture supernatant was analyzed by single and two-dimensional electrophoresis. Mass spectrometry analysis led to the identification of two serine protease inhibitors including a Bowman-Birk-type protein secreted by pea sprouts in response to clinical isolate. Expression of the E. coli intimin gene involved in animal host colonization and virulence was studied by reverse transcription polymerase chain reaction. Expression of this gene was high in SBANU8 when co-incubated with pea sprouts. The present study gives baseline data on the molecular level interactions of EPEC and pea sprouts, which are needed to design the outbreak control strategies.
Ana Gimenez Calpe
Full Text Available A parir del análisis comparativo de dos novelas recientes, Engel des Vergessens, de Maja Haderlap, y Caramelo o Puro cuento, de Sandra Cisneros, el artículo examina los mecanismos empleados en los textos para reescribir la historia nacional, recuperando y reorganizando para ello los recuerdos familiares de las narradoras protagonistas. Este proceso se produce en un contexto transnacional, en el que los límites entre países vecinos quedan cada vez más difusos. En este sentido, el artículo examina la reescritura de la memoria nacional desde la perspectiva de unos actantes determinados, esto es, de unos personajes en continuo tránsito entre fronteras.
Full Text Available The article deals with the main female characters that appear in Sandra Cisneros' collection of vignettes, House on Mango Street (1991. It sheds light on their lives and motives for their actions, through social criticism of Gloria Anzaldúa and the main points she establishes in her semi-autobiographical collection of essays Borderlands: La Frontera (1999. The topics Anzaldúa addresses give an insight into the Chicano identity, and the struggle of Chicano women in particular. Through her vantage point, I discuss gender roles, the immigrants' search for identity and their quest for a more dignified life, by trying to reconcile the antagonizing forces of the different parts of their identity.
Kim, Won-Seok; Chronis, Demosthenis; Juergens, Matthew; Schroeder, Amy C; Hyun, Seung Won; Jez, Joseph M; Krishnan, Hari B
Soybeans provide an excellent source of protein in animal feed. Soybean protein quality can be enhanced by increasing the concentration of sulfur-containing amino acids. Previous attempts to increase the concentration of sulfur-containing amino acids through the expression of heterologous proteins have met with limited success. Here, we report a successful strategy to increase the cysteine content of soybean seed through the overexpression of a key sulfur assimilatory enzyme. We have generated several transgenic soybean plants that overexpress a cytosolic isoform of O-acetylserine sulfhydrylase (OASS). These transgenic soybean plants exhibit a four- to tenfold increase in OASS activity when compared with non-transformed wild-type. The OASS activity in the transgenic soybeans was significantly higher at all the stages of seed development. Unlike the non-transformed soybean plants, there was no marked decrease in the OASS activity even at later stages of seed development. Overexpression of cytosolic OASS resulted in a 58-74% increase in protein-bound cysteine levels compared with non-transformed wild-type soybean seeds. A 22-32% increase in the free cysteine levels was also observed in transgenic soybeans overexpressing OASS. Furthermore, these transgenic soybean plants showed a marked increase in the accumulation of Bowman-Birk protease inhibitor, a cysteine-rich protein. The overall increase in soybean total cysteine content (both free and protein-bound) satisfies the recommended levels required for the optimal growth of monogastric animals.
Steinmetz, O M; Panzer, U; Fehr, S; Meyer-Schwesinger, C; Stahl, R A K; Wenzel, U O
The glomeruli in the non-clipped kidney of rats with 2-kidney, 1-clip hypertension are a classical model for studying the mechanisms of glomerular injury. In the present study, we compared the glomerular expression of PAI-1 and collagen I alpha1 mRNA from glomeruli isolated by the classic technique of sieving with the recently developed technique of tissue laser microdissection. For quantification of mRNA from both methods, real-time PCR was used. Real-time PCR revealed a 9.0 +/- 1.3- and a 7.1 +/- 0.2-fold induction of PAI-1 and collagen I alpha 1, respectively, in the glomeruli from hypertensive rats isolated by sieving. However, in situ hybridization and microdissection revealed that expression of both mRNAs was mainly from the Bowman's capsule and not from the glomerular tuft (10.7 +/- 1.3- and 7.2 +/- 0.6-fold higher induction in whole glomeruli compared with tuft alone). This emphasizes that studies focusing on processes in the mesangium, endothelial cells or podocytes should not rely on glomeruli obtained by sieving. Rather, a technique like the laser microdissection or in situ hybridization should be applied which allows the clear separation of different glomerular and periglomerular compartments.
Full Text Available Este trabalho se utiliza de dois estudos de caso - Viagem to Italy (1953, de Roberto Rossellini e Sandra (1965, de Luchino Visconti para discutir questões políticas, historiográficas e estéticas [que interferem] no relacionamento entre o neo-realismo como cinema da nação italiana e o "cinema de arte europeu" como uma instituição desnacionalizada.
Luis fernando Gómez R
Full Text Available This paper discusses the short story ‘El arroyo de la Llorona’ by female Mexican-American writer Sandra Cisneros. In it the main character, Cleófilas, is subject to social, emotional and economic dependence on her husband, according to the cultural constructs on female identity that are still relevant in Latin-American patriarchal societies. Due to her circumstances of complete marginalisation and domestic violence, Cleófilas chooses to avoid reality, and this avoidance not only costs her mental well-being,but also annuls her will to make changes to her suffocating life. Oppressed by a patriarchal system,Cleófilas develops an unusual interest in the Llorona legend and, through the remembrance of this myth, these two female figures become symbols of resistance and liberation. In the story, the Llorona ceases to be the denigrated woman tradition has always made her out to be, and becomes the image of a contemporary heroine capable of challenging radical patriarchal norms.
Jõgeva, Sandra, 1976-
Non Grata korraldatud rahvusvaheline performance'i-kunsti festival "Diverse Universe 2010" Pärnu Kunstihallis ja Pärnu Kunstnike Majas 23. ja 24. aprillil. Rühmituste Juurikasvu (Soome), Cnopt (Eesti), Rubensid (Eesti), Ornicart (Prantsusmaa), Zane Matule ja Gatis Vectirānsi (Läti) jt. performance'itest
Noronha Lúcia de
Full Text Available A hiperplasia embrionária epitelial da cápsula de Bowman (HEECB é uma rara alteração pós-diálise de rins em fase final de evolução, com poucas descrições na literatura mundial. Destaca-se a sua importância por simular histologicamente a nefroblastomatose universal, uma entidade pré-neoplásica precursora do tumor de Wilms. Neste artigo, relatamos o caso incomum de um paciente de 12 anos de idade, cujos rins, após 32 meses de terapia dialítica, apresentaram alterações compatíveis com HEECB.
Jõgeva, Sandra, 1976-
26. V toimunud tegevuskunstifestivali "Diverse Universe 2008" performance''i-konverentsist Pärnus Academia Non Grata majas. Tutvustati kollektiive HorseCow (California, Sacramento), GoGoTrash (Kesselberg), Berliini kunstnikerühmitust Open Space, 500 korea performance'i-kunstnikku koondavat isetekkelist organisatsiooni KOPAS - Korea Performance Art Spirit, ettekandega esines Brightoni kunstnik Orion Maxted
Jõgeva, Sandra, 1976-
Silja Saarepuu ja Villu Plingi näitus "Aknal" Pärnu Kunstihallis 28. veebruarini 2010. Suure osa eksponeeritud loomingust hõlmab nn väikeste inimeste teema. Jasper Zoova ruumiliste maalide näitus "Jass tuli koju" Jazz Cafés Pärnus 3. märtsini 2010
reduction, promoting greater social contact, and represent a ... Uberlândia-Brazil (CEP/UFU), receiving the .... Table 4: Profile of research subjects. .... Improvement of Higher Education Personnel ... Biominerals Company and to the teacher.
Jõgeva, Sandra, 1976-
Tutvustatakse kümmet kaasaegset kunstirühmitust ja -projekti: USA anonüümne kollektiiv The Yes Men, rahvusvaheline rühmitus The Biotic Pie Bacing Brigade, Hispaania rühmitus Yomango, taani disainerite rühmitus N55, poolaka Krzystof Wodiczko projekt, USA rühmitus Basekamp, Austraalia tegevuskunstniku Stelarc' projekt, USA rühmitus Pink Bloque ja Inglismaa rühmitus My Dads Strip Club
Jõgeva, Sandra, 1976-
Kuigi on majanduslik langus, tekib praegu juurde loomelinnakuid ja kultuuriruume (Rotermanni loovala, Baltika loomeinkubaator, Telliskivi loomelinnak jne.). Riia kesklinnas olid septembris projekti Survival Kit raames avatud ajutised kunstigaleriid südalinna äripindadel. Autori sõnul on õhus üheksakümnendate hõngu, vanad jõuvahekorrad enam ei kehti, tekib uusi võimalusi
Jõgeva, Sandra, 1976-
Eesti Kunstiakadeemia interdistsiplinaarsete kunstide osakonna ning Pärnu filmi- ja videofestivali alternatiivkino "Le Cinema Extraordinaire" (kuraatorid Erik Alalooga ja Ville-Karel Viirelaid) Tallinnas Nongrata Kunstikonteineris kultuuritehases Polymer 1.-22. II. Minna Hindi autoriõhtu (filmid "Kolm pilti elust ja ajast" ning "Sees või väljas") ja Jaan-Jürgen Klausi filmid "Sinitäheke" (peategelane Erkki Hüva) ning "Erakpoeet Marko Kompus"
Ilmunud ka: Postimees : na russkom jazõke 27. aug. 2008, lk. 7. Pakistani valitsuse lagunemisest, kui endine peaminister Navaz Sharif oma parteiga koalitsioonist lahkus. Vt. samas: Pakistani ahistavad separatistid ja majanduse allakäik. Kaart: Pakistan
Jõgeva, Sandra, 1976-
Pärnust pärit kunstnike näitus "Tagasi koju" Pärnu Linnagaleriis 13. augustini 2011. Kuraator Mari Kartau, kunstnikud Kaarel Kurismaa, Mari Kurismaa, Malle Leis, Marco Laimre, Maiu Rõõmus, Flo Kasearu, Elin Kard
Majanduslikult inaktiivsete ja mobiilsete Euroopa Liidu kodanike sotsiaalsetest õigustest Brexiti valguses. Euroopa Liidu kodanike liikumisvabadusest ja heaolu turismist. Sisaldab asjakohast kohtupraktikat
Pärnu Endla teatris etendunud lavastusest "Oma elu superstaarid". Autorid Triinu ja Laura-Marie Ojalo, lavastaja Enn Keerd, kunstnik Tuulikki Ojalo. Ka peategelase Eliis Vaiksaare (Lenna) osatäitmisest
Bruno de Freitas Valbon
Full Text Available OBJETIVO: Avaliar e comparar as alterações biomecânicas da córnea por meio do Ocular Response Analyzer® (ORA Reichert Ophtalmics Instruments, Buffalo, New York, USA antes e após Lasik com Moriá ® Sub Bowman Keratomileusis (SBK One Use Plus (OUP em pacientes míopes e hipermetrópes. MÉTODOS: Foram estudados 33 olhos, sendo 19 olhos míopes e 14 olhos hipermetrópes submetidos à cirurgia refrativa com técnica Lasik com flap fino (100 µ utilizando Moriá SBK OUP. O ORA foi realizado no pré-operatório e 1 mês após a cirurgia para avaliar a biomecânica da córnea. O CH (Corneal Hysteresis, CRF (Corneal Resistance Factor, IOPg (goldmann gold standard, Goldmann correlated intraocular pressure a IOPcc (corneal compensated intraocular pressure e mais 38 variáveis biomecânicas da córnea derivadas do sinal de resposta foram avaliados. O Teste de Kolmogorov-Smirnov foi utilizado para avaliar a distribuição normal. O teste de Wilcoxon foi utilizado para comparar as variáveis antes e após a cirurgia para cada grupo. As diferenças entre as medidas pré e pós-operatórias dos olhos míopes foram comparadas com as diferenças obtidas nos olhos hipermetrópes, utilizando-se o teste de Mann-Whitney. Foi considerado como estatisticamente significante p < 0,05%. RESULTADOS: Houve diferença significativa antes e após Lasik em olhos míopes e hipermetrópes na variável IOPg(Wilcoxon, p <0,05, porém não houve em IOPcc. Somente em olhos míopes houve diferenças significativas em CH e CRF, antes e após Lasik com Moriá SBK OUP, como também 9 parâmetros derivados do ORA Waveform_Sinal Gráfico (aspect1, h1, dive1, path1, p1area1, W11, H11, and w2 path11; Wilcoxon, p <0,05. Em olhos hipermetrópes houve diferenças antes e após Lasik das seguintes variáveis: aspect2, h2, dive2, mslew2 e H21 (Wilcoxon p<0,05.Diferenças nas variáveis IOPg e p1area, antes e após Lasik foram maiores em olhos míopes do que hipermetrópes (Mann-Whitey, p
Gherman, P. L.
This work is about a relatively new domain. The DC electric arc is superior to the AC electric arc and it’s not used in Romania. This is why we analyzed the work functions of these furnaces by simulation and model checking of the simulation results.The conclusions are favorable, to be carried is to develop a real-time control system of steel elaboration process.
tamping rollers. Final compaction was by rubber -t ired rollers. Compaction was to 95% of maximum density. Time between placing the 6" layers and...taree ue go dscribe*he:. 0 IoldNYeRAEL Boreast ol bsnc of eater readngs in the Iiraphic Log ’G I CAYI CQ 5A esL.- ADS@ * nbr ; i cneeeiItt be oetrued O
Squires, Frances H.
This science curriculum was written for teachers of children in the elementary grades. It contains science activities for the following lessons: (1) Whirly Birds and the Concept of Lift; (2) Parachutes; (3) Weather Vanes; (4) Paper Airplanes; (5) Flying an Airplane; (6) Jet Engine; (7) Identifying Flying Objects; (8) It's a Bird! It's a Plane; (9)…
Conclusion: In the normal adult kidney, there may be an optimal BV to GV ratio for maintaining effective filtration in a variety of clinical situations, including advanced age, obesity, and hypertension.
Ostalska-Nowicka, D; Nowicki, M; Zachwieja, J; Kasper, M; Witt, M
To analyse the expression of caveolin-1 in normal human kidney and during diseases leading to nephrotic syndrome in children and to compare its pattern with those observed in control samples, both human and animal. The study group was composed of 104 children diagnosed with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), lupus glomerulonephritis (LGN) and Schönlein-Henoch glomerulopathy (SH). The research protocol employed direct immunohistochemical assay with the use of mono- and polyclonal antibodies against caveolins. Kidney samples of Wistar rats, wild-type mice and caveolin-1-deficient mice were also analysed. In the control human samples, caveolin-1 was most abundant in the muscle layer of blood vessels and parietal epithelial cells (PECs). Its expression in PECs was significantly lower in children diagnosed with FSGS and LGN than in those with MCD, SH or in controls. In the control animal tissues, except for knock-out mice, caveolin-1 was present in distal convoluted tubules, PECs, endothelial cells and muscle. Caveolae are extremely stable elements of PECs and can be excluded from their cell membrane only in response to the dramatic cell reconstruction observed in FSGS and LGN.
Riia Kunstiruumi (Riga Art Space) turundusjuht Inga Lace Raekoja platsi all asuvast uuest näitusepaigast, selle tööpõhimõtetest ning eesti kunstnike - Jaan Tooniku ja Andrus Joonase näitus suures saalis, Kaido Ole ja Tõnis Saadoja näitus väikses saalis- vastuvõtust Lätis. Septembris avatakse Johannes Saare kureeritud rahvusvaheline projekt "Halb nali"
2004. a. paremtsentristliku Demokraatliku Partei juhina valimistel võitnud Janez Jansha on populaarsust kaotamas ning peatsed valimised ei tõota ennustuste põhjal erilist edu. Dissidendist kõvakäemeheks. Korruptsioonisüüdistused seoses Soome relvafirma tehinguga
Fuselli, Sandra Rosa
El Grupo Microbiología Aplicada (GIMA), perteneciente al Centro de Investigación en Abejas Sociales (CIAS) de la FCEyN-UNMdP, bajo la dirección de Dra. SR Fuselli, desarrolla dos líneas de investigación: Sanidad apícola: Productos naturales bioactivos, y Calidad y trazabilidad de productos agroalimentarios. En este contexto, se están llevando a cabo estudios sobre la actividad antimicrobiana y antipatogénica de PRODUCTOS NATURALES, concr...
Full Text Available The paper takes Candra Cisneros' epic semi-biographical novel Caramelo asa literary insight into dynamics between generations within a single ethnic (Chicano community, and compares it against classics of the genre in its shifting definition of one's ethnic identity; here the postmodern approach of entwining fiction and fact and awarding them equallegitimacy mirrors the possibility of embracing multiple identities, as exemplified by the novel's protagonist.
24 arvustaja vastus küsimusele, milline oli 2010. aasta parim uudisteos ja debüüt. Parima uudisteosena nimetati enim Kalju Kruusa luulekogu "Tühhja", Ene Mihkelsoni luulekogu "Torn" ning Lauri Sommeri proosaraamatut "Kolm yksiklast". Parimaks debüüdiks peeti Siim Nurkliku näidendit "Kas ma olen nüüd elus".
lapsed ja lapsevanemad Austraaliast meenutavad oma viibimist Sõrve lastelaagris: This is a story of a family from Sõrve; Nicholas Wurm - Age 9 (Adelaide); Alan and Debbie Mikkor (Melbourne); Jesse Mikkor's point of view: Age 8; Lauren Mikkor's point of view: Age 13
Niitra, Nils, 1975-
Vt. ka Tartu Postimees 16. juuni, lk. 1 ; Postimees : na russkom jazõke 19. juuni, lk. 9. Pärnu haiglas saavad kõik patsiendid, kel tervis lubab, palatis sülearvutiga traadita internetti kasutada. Tartu ja Tallinna haiglates levib WiFi esialgu tagasihoidlikumalt - kui üldse, siis ainult osas ruumidest
Jõgeva, Sandra, 1976-
1.-22. veebruarini 2008 toimub Tallinnas Nongrata Kunstikonteineris Kultuuritehases Polymer Eesti Kunstiakadeemia interdistsiplinaarsete kunstide kateedri ja Pärnu filmi- ja videofestivali korraldatav alternatiivkino "La Cinema Extraordinaire"
Alice da Cunha M. Álvares
Full Text Available The hydrolysis of bradykinin (Bk by different classes of proteases in plasma and tissues leads to a decrease in its half-life. Here, Bk actions on smooth muscle and in vivo cardiovascular assays in association with a protease inhibitor, Black eyed-pea trypsin and chymotrypsin inhibitor (BTCI and also under the effect of trypsin and chymotrypsin were evaluated. Two synthetic Bk-related peptides, Bk1 and Bk2, were used to investigate the importance of additional C-terminal amino acid residues on serine protease activity. BTCI forms complexes with Bk and analogues at pH 5.0, 7.4 and 9.0, presenting binding constants ranging from 103 to 104 M−1. Formation of BTCI-Bk complexes is probably driven by hydrophobic forces, coupled with slight conformational changes in BTCI. In vitro assays using guinea pig (Cavia porcellus ileum showed that Bk retains the ability to induce smooth muscle contraction in the presence of BTCI. Moreover, no alteration in the inhibitory activity of BTCI in complex with Bk and analogous was observed. When the BTCI and BTCI-Bk complexes were tested in vivo, a decrease of vascular resistance and consequent hypotension and potentiating renal and aortic vasodilatation induced by Bk and Bk2 infusions was observed. These results indicate that BTCI-Bk complexes may be a reliable strategy to act as a carrier and protective approach for Bk-related peptides against plasma serine proteases cleavage, leading to an increase in their half-life. These findings also indicate that BTCI could remain stable in some tissues to inhibit chymotrypsin or trypsin-like enzymes that cleave and inactivate bradykinin in situ.
Sippel, M.A.; Luff, K.D.; Hendricks, M.L.; Eby, D.E.
This topical report is a compilation of characterizations by different disciplines of the Red River Formation in the southwest portion of the Williston Basin and the oil reservoirs which it contains in an area which straddles the state line between North Dakota and South Dakota. Goals of the report are to increase understanding of the reservoir rocks, oil-in-place, heterogeneity, and methods for improved recovery. The report is divided by discipline into five major sections: (1) geology, (2) petrography-petrophysical, (3) engineering, (4) case studies and (5) geophysical. Interwoven in these sections are results from demonstration wells which were drilled or selected for special testing to evaluate important concepts for field development and enhanced recovery. The Red River study area has been successfully explored with two-dimensional (2D) seismic. Improved reservoir characterization utilizing 3-dimensional (3D) and has been investigated for identification of structural and stratigraphic reservoir compartments. These seismic characterization tools are integrated with geological and engineering studies. Targeted drilling from predictions using 3D seismic for porosity development were successful in developing significant reserves at close distances to old wells. Short-lateral and horizontal drilling technologies were tested for improved completion efficiency. Lateral completions should improve economics for both primary and secondary recovery where low permeability is a problem and higher density drilling is limited by drilling cost. Low water injectivity and widely spaced wells have restricted the application of waterflooding in the past. Water injection tests were performed in both a vertical and a horizontal well. Data from these tests were used to predict long-term injection and oil recovery.
Squires, Frances H.
This science curriculum was written for teachers of children in junior high or middle school. It contains science activities for the following lessons: (1) Anemometers and Wind Speed; (2) Up! Up! and Away; (3) Jet Lag--Time Zones; (4) Inventors; (5) Model Rocketry; (6) Geometry and Kites; and (7) Super Savers. In lesson one, students construct an…
City branding of contested cities with violent histories has taken hold of hearts, but what kind of love is conducive to establishing and furthering democratic communities - and how can artists approach this subject matter in a credible way? In Belfast, Northern Ireland, o cials decided to demolish
Artiklis käsitletakse ühiskonna normatiivse kliima mõju indiviidi hoiakutele kahe ebatraditsioonilise soorolli (vabatahtlik lastetus ja töötamine täistööajaga ajal, mil lapsed on väiksed) puhul, aluseks 21 riigi (sh Eesti) Euroopa sotsiaaluuringu andmed
Full Text Available No início de 2012, em um painel de alto nível da ONU sobre “Sustentabilidade Global”, os 22 líderes mundiais que redigiram o relatório Pessoas Resilientes, Planeta Resiliente: o caminho que vale a pena seguir - debatido também na Rio + 20 - argumentaram que as mulheres são fundamentais para o desenvolvimento sustentável. Mas, alertaram que, para valorizar esse papel, a igualdade de gênero e o empoderamento das mulheres devem alcançar uma dimensão mais significativa no âmbito econômico. “A persistente desigualdade de gênero tem que ser abordada como parte de qualquer virada séria em direção ao desenvolvimento sustentável”, afirmou o painel. Infelizmente, fora das recomendações de órgãos como a ONU, a realidade ainda está longe de ser a ideal. No mundo atual, mulheres de todas as idades, culturas e condições sociais enfrentam os maiores desafios socioeconômicos e culturais.
Kosová, K.; Prášil, I.T.; Vítámvás, P.; Dobrev, Petre; Motyka, Václav; Floková, Kristýna; Novák, Ondřej; Turečková, Veronika; Rolčík, Jakub; Pešek, Bedřich; Trávníčková, Alena; Gaudinová, Alena; Galiba, G.; Janda, T.; Vlasáková, E.; Prášilová, P.; Vaňková, Radomíra
Roč. 169, č. 6 (2012), s. 567-576 ISSN 0176-1617 R&D Projects: GA ČR GA522/09/2058; GA MŠk MEB040713; GA MŠk MEB040924 Grant - others:GA ČR(CZ) GPP501/11/P637 Program:GP Institutional research plan: CEZ:AV0Z50380511 Keywords : Cold stress * Dehydrin * Frost tolerance Subject RIV: ED - Physiology Impact factor: 2.699, year: 2012
Eesti koolides kantavatest koolivormidest. Pikemalt Katrin Kivi disainitud Tallinna Saksa gümnaasiumi koolivormist ja Tallinna Arte gümnaasiumi koolivormist. Katrin Kivi ja Peeter Kreitzbergi kommentaarid. 8 ill.
Keskkooliõpetajatega läbi viidud intervjuude tulemused viitavad veebisisu loomega kaasnevatele põlvkondlikele erinevustele ning avavad õpetajate-õpilaste probleeme suhtlusportaali auditooriumi tajumisel
Polymeri kultuuritehases Tallinnas (Ülase 16 / Madara 22) tegutsevast Academia Non Grata filiaalist ja alternatiivgaleriist Nongrata Kunstikonteiner. Näitustest, tulevikuplaanidest. Avanäituseks oli "Uus laine. 21. sajandi kunst", juuni lõpuni on avatud rahvusvahelise performance'ifestivali "Diverse Universe III" avanäitus "Aderlassenplatz" ja "Uus laine. II valik: tegevuskunst"
Full Text Available The House on Mango Street has been translated into more than 20 languages worldwide, including Croatian in 2005. The novel has secured a firm foothold in many a literature and cultural studies syllabus outside the USA and has served as one of central entry points for the discussion and understanding of the position of women in America’s ethnicized communities. In its treatment of women’s disadvantaged position, Cisneros’s novel relies heavily on the tenets of liberal feminism, which reduces the understanding of gendered oppression to personal relationships between individual men and women and to the attitudes of men towards women. Unlike liberal feminist literary theory, systemic feminist literary theory takes a broader social context into consideration by directing our critical gaze to the structural forces and institutional practices that shape gendered positions and defi ne the role of women inside and outside family settings. Th e paper shows that because of its subscription to the tenets of liberal feminism, the novel ends up treating gender constraints and women’s domestication as though these were phenomena limited only to ethnicized communities. As a result, women’s marginalization comes to be construed as a marker of ethnic otherness rather than a structural problem defining and permeating American society as a whole. Through translations, these constructs are inadvertently also carried over and can be uncritically disseminated in other cultural and academic environments outside the USA. The paper therefore argues for the need for a systemic literary approach, which can function as a welcome and much needed critical intervention in social milieus not yet fully acquainted with the problematic nature of liberal feminism and the ethnicization of women’s domestic entrapment.
Bowman, William R.; Crawford, Alice M.; Mehay, Stephen
Approved for public release; distribution unlimited. The goal of this study was to analyze the effectiveness of the new SWOS-at-Sea training for newly commissioned surface warfare officers that was introduced in 2003. The new regime combined self-paced computer-based training (CBT) with on-the-job training (OJT) on-board an officer's ship. The study relied on a variety of analytical techniques, including a literature review of CBT and OJT training, interviews and focus groups with junior a...
Methylocystis bryophila sp. nov., a facultatively methanotrophic bacterium from acidic Sphagnum peat, and emended description of the genus Methylocystis (ex Whittenbury et al. 1970) Bowman et al. 1993.
Belova, Svetlana E; Kulichevskaya, Irina S; Bodelier, Paul L E; Dedysh, Svetlana N
A novel species is proposed for two facultatively methanotrophic representatives of the genus Methylocystis, strains H2s(T) and S284, which were isolated from an acidic (pH 4.3) Sphagnum peat-bog lake (Teufelssee, Germany) and an acidic (pH 3.8) peat bog (European North Russia), respectively. Cells of strains H2s(T) and S284 are aerobic, Gram-negative, non-motile, curved coccoids or short rods that contain an intracytoplasmic membrane system typical of type-II methanotrophs. They possess both a soluble and a particulate methane monooxygenase (MMO); the latter is represented by two isozymes, pMMO1 and pMMO2. The preferred growth substrates are methane and methanol. In the absence of C1 substrates, however, these methanotrophs are capable of slow growth on acetate. Atmospheric nitrogen is fixed by means of an aerotolerant nitrogenase. Strains H2s(T) and S284 grow between pH 4.2 and 7.6 (optimum pH 6.0-6.5) and at 8-37 °C (optimum 25-30 °C). The major fatty acids are C18 : 1ω8c, C18 : 1ω7c and C16 : 1ω7c; the major quinone is Q-8. The DNA G+C content is 62.0-62.3 mol%. Strains H2s(T) and S284 share identical 16S rRNA gene sequences, which displayed 96.6-97.3 % similarity to sequences of other taxonomically characterized members of the genus Methylocystis. Therefore, strains H2s(T) and S284 are classified as members of a novel species, for which the name Methylocystis bryophila sp. nov. is proposed; strain H2s(T) ( = DSM 21852(T) = VKM B-2545(T)) is the type strain.
Kallas, Sandra, 1987-
Eutannasia mõistest ja liikidest, aktiivse eutanaasia õiguslikest ja eetilistest küsimustest, eutanaasiast teistes riikides (Holland, Belgia, Jaapan), eutanaasia seadustamise võimalikkusest Eestis
Adriana Macedo Nadal Maciel
Chicano ou mexicano-americano e dominicano-americano: grupos com a latinidade presente em sua existência, uma língua e a origem hispânica em comum, mas com trajetórias distintas dentro dos Estados Unidos. A experiência de viver no hífen, o lugar da união (ou da colisão) entre dois mundos, se encontra dramatizada em obras de escritoras que, a partir de suas próprias experiências imigrantes, mostram a difícil travessia de uma cultura para outra e oferecem reflexões sobre a aceitação de su...
Couper, Pauline; Stoakes, Geoff
The "research-teaching nexus" has been the subject of much recent debate, yet little attention has been paid to institutional initiatives to promote and encourage the integration of teaching and research. This article presents a novel diagrammatical representation of the relationship between research and teaching which was developed to aid the…
Fransman, Johanna Sandra
Metacognition is commonly understood in the context of the learners and not their teachers. Extant literature focusing on how Mathematics teachers apply their metacognitive skills in the classroom, clearly distinguishes between teaching with metacognition (TwM) referring to teachers thinking about their own thinking and teaching for metacognition (TfM) which refers to teachers creating opportunities for learners to reflect on their thinking. However, in both of these cases, thinking requires ...
Souza, Marcos Santana de
A etnografia ganhou importância a partir dos trabalhos de Bronislaw Malinowski e de seus discípulos, que impulsionaram o desenvolvimento do método durante a chamada fase moderna da antropologia. Desde então, a etnografia, que inicialmente se referia à “descrição dos significados de um determinado grupo”, superou os limites dessa definição e do próprio pensamento antropológico e passou a ser utilizada com maior frequência no âmbito das ciências humanas e sociais, ainda que continue sendo vista...
Villamizar, Juan Carlos
El libro ganador del vii Premio Nacional de Educación Francisca Radke, versión 2005-2006, se compone de una introducción y tres capítulos, en los que la autora se ocupa de las prácticas de sujeción, corrección y disciplina a finales del siglo xviii y comienzos del xix, en que la administración colonial llegó a su fin en América. Los dos primeros capítulos abordan la problemática de la pobreza y las propuestas de cómo tratarla. El tercer capítulo se ocupa de la pedagogía social de masas y de l...
Juan Carlos Villamizar
Full Text Available El libro ganador del vii Premio Nacional de Educación Francisca Radke, versión 2005-2006, se compone de una introducción y tres capítulos, en los que la autora se ocupa de las prácticas de sujeción, corrección y disciplina a finales del siglo xviii y comienzos del xix, en que la administración colonial llegó a su fin en América. Los dos primeros capítulos abordan la problemática de la pobreza y las propuestas de cómo tratarla. El tercer capítulo se ocupa de la pedagogía social de masas y de la asistencia, enseñanza y corrección de pobres, mendigos, vagos y malentretenidos en Santa Fe de Bogotá entre 1780 y 1820. A diferencia de los dos primeros capítulos, este último está construido estrictamente con fuentes primarias.
Maria Terezinha Serafim Gomes
Full Text Available O livro aqui apresentado “Geografia Econômica: (re leituras contemporâneas” é uma coletânea com 9 capítulos, reunindo pesquisadores das regiões Sul, Sudeste e Centro-Oeste do Brasil, que se debruçam sobre a temática da Geografia Econômica. No prefácio, os organizadores apresentam ao leitor a riqueza de temas relacionados à Geografia Econômica abordados no livro, a saber: América do Sul, economia mundial, crise energética, indústria do petróleo, tradings agroindústrias, cooperativas, informação, internacionalização do capital, empresas internacionais, capital estrangeiro, dinâmica econômica, logística e reestruturação produtiva.
... 17091 New York. Levine Seth A 09759 New York. Walsh John X 03979 New York. Palmieri Eugene D 02632 New.... Galik Jane M 10357 Philadelphia. D'Amico Lenore Anne 15093 Philadelphia. Frederick Ted D 10654...
Sandra Jõgeva kuraatoriprojektist "Loomakari" Tallinna Kunstihoones, avatud 12. aprillini. Kujundaja Tanel Saar. Sandra Jõgeva, Tanel Saare, Anthony Faroux' (Inglismaa), Jenni Juulia Wallinheimo (Soome) ja Kjetil Kauslandi (Norra) töödest
Lengel, Edward J; Rambo, Charles R; Rodriguez, Shelley A; Tyynismaa, Michael D
.... Henry Mintzberg's structural contingency model and Lee Bowman and Terrence Deal's frames model within organizational theory are applied to the executive-level decisions made during the operation...
College Students in an Experimental Study Took Longer to Achieve Comprehension when Instant Messaging while Reading. A Review of: Bowman, L. L., Levine, L. E., Waite, B. M., & Gendron, M. (2010). Can students really multitask? An experimental study of instant messaging while reading. Computers & Education, 54, 927-931.
Megan von Isenburg
Objective – To examine the effects of multitasking while doing school work. The experiment specifically measured total time spent reading a simulated textbook passage and tested comprehension in students who received instant messages before reading, while reading, or not at all.Design – Experimental design in which one group of students read an online text while receiving and responding to instant messages. Comparison groups either received instant messages (IMs) prior to reading the text pas...
College Students in an Experimental Study Took Longer to Achieve Comprehension when Instant Messaging while Reading. A Review of: Bowman, L. L., Levine, L. E., Waite, B. M., & Gendron, M. (2010. Can students really multitask? An experimental study of instant messaging while reading. Computers & Education, 54, 927-931.
Megan von Isenburg
Full Text Available Objective – To examine the effects of multitasking while doing school work. The experiment specifically measured total time spent reading a simulated textbook passage and tested comprehension in students who received instant messages before reading, while reading, or not at all.Design – Experimental design in which one group of students read an online text while receiving and responding to instant messages. Comparison groups either received instant messages (IMs prior to reading the text passage or did not receive any IMs during the task.Setting – General psychology department at Central Connecticut State University, United States.Subjects – Eighty-nine college students enrolled in general psychology courses. The participants included 43 women and 46 men and were between 17 and 46 years old. Most students were full time students (91%, most were European / White (74% and in their first (46% or second (33% year of college. Participants’ academic majors represented all the schools in the university.Methods – Researchers created a simulated environment in which a passage from a psychology textbook was displayed on five consecutive screens. For the experimental group, an IM appeared on each of the five screens preceded by an alert sound. Messages were written to reflect the types of questions students might ask each other when they first meet, such as “What do you like to do in your spare time?”Subjects were randomized to three situations: receiving IMs before reading, receiving IMs during reading, or not receiving any IMs. Subjects were told that they would either receive IMs before reading, while reading, or not at all. Messages received during reading appeared one per screen after a specified time spent on each page (after 17, 15, 29, 20 and 26 seconds, respectively. Students could take as long as necessary to read the passage and to respond to IMs.After reading the passage, students were given a multiple choice test with 25 questions to determine reading comprehension and retention. Students also completed a demographic questionnaire to measure their typical instant messaging behaviour, including the amount of time they spend each week instant messaging, how often IM software is on when their computer is on, and how often IM software is on when they are studying. Both of these activities took place on the same computers used for the reading experiment.Students were additionally asked to comment on the clarity of instructions, the representativeness of the task to their typical IM experiences, and the interest and similarity to normal coursework of the reading itself. These questions were asked on paper rather than on the computer.Software recorded the lengths of time each student spent in reading the passage, reading and responding to IMs, and answering the online questions. For those students who received IMs during reading, the time spent from receipt of each IM to each response was subtracted from the total reading time.Main Results – There were no differences in test performance between the three groups. Statistically significant differences were found in the amount of time that students took to complete the reading: students who instant messaged during reading took significantly longer to read the online text than those students who instant messaged before reading and those who did not IM, even when time spent receiving and responding to IMs was subtracted from the totals. Students who instant messaged before reading took the least amount of time in the exercise. Further statistical analysis revealed no significant differences in the time spent instant messaging between the two IM groups.Responses to the demographic questions indicate that students spend a mean 7.5 hours instant messaging per week, that 67% of students have IM software on “sometimes,” “often,” or “very often” while the computer is on and 62% of the time while studying. Analysis indicated that none of the IM use variables were correlated with test performance or reading time and that there were no significant differences between the experimental groups according to prior IM use.Responses from the 77 students who answered the questions about the experiment itself are also included, though not all of these students answered each question. Seventy students (99% agreed or strongly agreed that instructions were clear. Seventy-one percent of the 52 students that received IMs agreed or strongly agreed that they were realistic, and 75% agreed or strongly agreed that they responded to IMs in a typical manner. Sixty-two students (82% agreed or strongly agreed that the text was similar to those assigned for actual coursework, and 39 students (51% agreed or strongly agreed that the passage was interesting. Students commented on the authenticity of the experiment in free text responses such as, “I responded how I would have to anyone,” and “they were questions that anyone I don’t know might ask.”Conclusion – This experimental study suggests that students who IM while reading will perform as well but take longer to complete the task than those who do not IM while reading or those students who IM before reading.
III rahvusvaheline video ja performance'i festival "Inport 2005", mille on kokku pannud Gert Hatsukov. Loetletud aktsioonide autorid (Eesti: Sandra Jõgeva, Yellow Wolfman [Andrus Joonas], Andres Tenusaar)
Fernando, Arghya Dey, Bernadette M. Broderick , Bina Fu, Zahra Homayoon, Joel M. Bowman, Arthur G. Suits. Visible/Infrared Dissociation of NO, The...Manuscripts 10/01/2014 10/01/2014 12/02/2015 10.00 Received Paper 7.00 8.00 Bernadette M. Broderick , Bina Fu, Zahra Homayoon, Joel M. Bowman, Arthur G. Suits
The Majority of Library Clients Still Use Person-to-Person Interaction When Asking Reference Questions. A review of: De Groote, Sandra L. “Questions Asked at the Virtual and Physical Health Sciences Reference Desk: How Do They Compare and What Do They Tell Us?” Medical Reference Services Quarterly 24.2 (Summer 2005: 11-23.
Suzanne Pamela Lewis
Full Text Available Objective - To identify similarities and difference in the questions asked at the virtual and physical refernece desks of a helath scienmces library, in order to better undertand user needs and highlight areas for service improvement. Also to retrospectively analyze reference statistics collected over the previous six years. Design - Use study; retrospective study of reference statistics for the period July 1997 to June 2003; literature review. Setting - Large academic helath sciences library in the United States. Subjects - All questions asked at the reference and information desks, plus questions submitted to the University-wide virtual reference service and answered by a health sciences librarian, over a period of one month. The questions were asked by faculty, staff, students and members of the public. Methods - A literature review was carried out to examine the types of information/reference questions typically asked in health sciences libraries both before and after the mass introduction of remote end-user searching of online resources and the establishment of virtual reference services. Next, the reference statistics collected at the University of Illinois at Chicage (UIC Library of the Health Sciences between July 1997 and June 2003 were examined. For most of this period a digital reference service was offered using a listserv address to which patrons would submit email queries. Beginning in March 2003, a formal virtual reference service (chat and email was provided using commercial software. Finally, data was gathered on questions answered by a health sciences librarians, and clients who asked the question, at either the physical or cirtual reference desk, during the month of November 2003 at the UIC Library of the Health Sciences. Library staff completed an online survey form for each question, and if a client asked more than one question, each question was coded individually. Data included: status of client using the service (faculty/staff. undergarduate student, graduate student, non0UIC, unknown; mode of submission (email, chat, phone, in person; and type of question asked (directional, ready reference, in-depth/mediated, instructional, technical, accounts/status and other. In subsequent analysis, the original seven types of questions were further broken down into 19 categories. Main results - It was not possible to undertake a meta-analysis or systematic review of the studies identified in the literature review because of differences in time frames, settings and the categories used to code reference questions. However the following trends emerged: directional questions accounted for between 30 and 35% of questions asked at both the physical and virtual reference desks; the remainder of questions were generally about known item searched, library policies and services, research, dadabase use and quick reference. The statistics collected at UIC Library of the Health Sciences over the period July 1997 to June 2003 were analyzed. Coded reference questions fell into one of four categories; ready reference, in-depth reference, mediated searched and digital reference. There was a noticeable drop in the number of reference questions received in 1999/2000 which reflects trends reported in some of the studies identified in the literature review. The number of mediated searches decreased from 154 in 1997-98 to 4 in 2002/2003, but the number of digital reference questions increased from 0 to 508 in the same period. Statistics were collected over the month of November 2003 for 939 questions asked at the reference and information desks which included: 38 email; 48 chat; 156 phone; and 697 in person. The major findings were as follows: - appoximately 55% of questions were reference questions (33.5% ready reference, 9.7% in-depth/mediated, 9.7% instructional; 30% were directional; and 10% were technical; it is not stated what the remaining 5% of questions were; - library clients who asked the questions comprised graduate students (26%, faculty (24%, undergraduate students (24% and non-UIC patrons (22%; - all groups were most likely to ask their reference questions in person; - graduate students were the largest group of email reference (34%, undergraduates were the largest group to use chat (35% and faculty/staff were the largest group to use the telephone (39%; - 28% of the questions were answered from the library's staff's general knowledge of the library; 22% using the online catalogue or electronic journals list; 22% by referrning the patron to, or using an online database or resource; 13% by referring the patron to another department in the library (such as circulation; 7% by consulting another individual; and 5% by using print resources. Conclusion - The results of the three parts of this study - literature review, study of 1997-2003 statistics, and in-depth collection of statistics for November 2003 - are difficult to compare with each other. However, the general trend emerging from the results is that some kinds of questions asked by health sciences library clients have remained very much the same regardless of the rise of remote end-user searching and the mode of transmission of the questions. These include questions about library policies and services, journal and book holdings, database searching and instructional support. Questions about citation verification and consumer health appear to be decreasing while technical questions and questions about accessing remote databases and online journals are increasing. The majority of reference questions are still asked in person.
Eduardo L. Holmberg, Dos partidos en lucha. Fantasía científica : Buenos Aires, Corregidor, 2006, introducción y selección de apéndices: Sandra Gasparini, colección Voces y Letras del Plata, 269 páginas
Es posible que, guiado por el título y por la fecha de la primera edición de Dos partidos en lucha (1875), un eventual lector sospeche que en esta novela breve se alude a las disputas que un año antes habían enfrentado a mitristas y alsinistas a propósito de la elección del candidato que debía suceder a Sarmiento en la presidencia; un conflicto que derivó en la elección de Nicolás Avellaneda y, a continuación, en el alzamiento de Mitre, reprimido finalmente por tropas leales al gobierno en la...
Eisner, Elliot W.
Reprints the 1966 article as a representative example of thinking about art education during the 1960s. Primarily answers criticisms raised by Victor D'Amico in his attack on the current state of art education, and art education research in particular. Defends this research against charges of irrelevancy and academic indulgence. (MJP)
Garza Mitchell, Regina L.
Very little empirical research has been conducted about online career and technical education (CTE). Despite the continuing enrollment growth in online education (Lokken, 2016) and the national emphasis on CTE as a means of boosting the economy (D'Amico, Morgan, Katsinas, & Friedel, 2014), relatively little is understood about the scope and…
Anmeldelse af: Bruner og de små børns læring - en introduktion af Sandra Smidt, Hans Reitzels Forlag, 2013.......Anmeldelse af: Bruner og de små børns læring - en introduktion af Sandra Smidt, Hans Reitzels Forlag, 2013....
Nov 15, 2014 ... Key words: Foraging site, Insectivorous birds, Burn, Vegetation structure, Food availability. Introduction .... insects constituting diet of the two insectivorous birds are not .... relationship as reported in previous studies. (Bowman ...
Research Paper An exploratory study of psychological and developmental issues facing HIV and AIDS affected adolescents living in a residential care facility. Myrthe Van Vilsteren, Sadiyya Haffejee, Rabia Patel, Brett Bowman ...
... James C. Askin, Paul J. Bannon, Ernie E. Black, Ronnie F. Bowman, Gary O. Brady, Stephen H. Goldcamp, Steven F. Grass, Wai F. King, Dennis E. Krone, Richard J. McKenzie, Jr., Christopher J. Meerten, Craig W...
.... Askin, Paul J. Bannon, Ernie E. Black, Ronnie F. Bowman, Gary O. Brady, Stephen H. Goldcamp, Steven F. Grass, Wai F. King, Dennis E. Krone, Richard J. McKenzie, Jr., Christopher J. Meerten, Craig W. Miller...
Smeets, B.; Angelotti, M.L.; Rizzo, P.; Dijkman, H.; Lazzeri, E.; Mooren, F.; Ballerini, L.; Parente, E.; Sagrinati, C.; Mazzinghi, B.; Ronconi, E.; Becherucci, F.; Benigni, A.; Steenbergen, E.; Lasagni, L.; Remuzzi, G.; Wetzels, J.F.M.; Romagnani, P.
Glomerular injury can involve excessive proliferation of glomerular epithelial cells, resulting in crescent formation and obliteration of Bowman's space. The origin of these hyperplastic epithelial cells in different glomerular disorders is controversial. Renal progenitors localized to the inner
Miesen, Laura; Steenbergen, Eric; Smeets, Bart
In normal glomeruli, parietal epithelial cells (PECs) line the inside of Bowman?s capsule and form an inconspicuous sheet of flat epithelial cells in continuity with the proximal tubular epithelial cells (PTECs) at the urinary pole and with the podocytes at the vascular pole. PECs, PTECs and podocytes have a common mesenchymal origin and are the result of divergent differentiation during embryogenesis. Podocytes and PTECs are highly differentiated cells with well-established functions pertain...
Berger, Katja; Schulte, Kevin; Boor, Peter; Kuppe, Christoph; van Kuppevelt, Toin H; Floege, Jürgen; Smeets, Bart; Moeller, Marcus J
Previously, we showed that some podocytes in juvenile mice are recruited from cells lining Bowman's capsule, suggesting that parietal epithelial cells (PECs) are a progenitor cell population for podocytes. To investigate whether PECs also replenish podocytes in adult mice, PECs were genetically labeled in an irreversible fashion in 5-week-old mice. No significant increase in labeled podocytes was observed, even after 18 months. To accelerate a potential regenerative mechanism, progressive glomerular hypertrophy was induced by progressive partial nephrectomies. Again, no significant podocyte replenishment was observed. Rather, labeled PECs exclusively invaded segments of the tuft affected by glomerulosclerosis, consistent with our previous findings. We next reassessed PEC recruitment in juvenile mice using a different reporter mouse and confirmed significant recruitment of labeled PECs onto the glomerular tuft. Moreover, some labeled cells on Bowman's capsule expressed podocyte markers, and cells on Bowman's capsule were also directly labeled in juvenile podocyte-specific Pod-rtTA transgenic mice. In 6-week-old mice, however, cells on Bowman's capsule no longer expressed podocyte-specific markers. Similarly, in human kidneys, some cells on Bowman's capsule expressed the podocyte marker synaptopodin from 2 weeks to 2 years of age but not at 7 years of age. In summary, podocyte regeneration from PECs could not be detected in aging mice or models of glomerular hypertrophy. We propose that a small fraction of committed podocytes reside on Bowman's capsule close to the vascular stalk and are recruited onto the glomerular tuft during infancy to adolescence in mice and humans.
Ranganath, Heggere S Ranganathan, J. Rao, S Raskin, Rob Raven, P H Redman, Sandra Reed, D Reed, Daniel Months Blakeslee RJ, Stewart MF, Hawkins DL, Mach DM, Wharton NA, Ranganathan J, He Y, Flynn SE, Garrett
Three approaches are used for coming towards a definition of Biblical spirituality. The ..... Donahue is that he shows how the ideas of Sandra Schneiders are rooted in the .... The central part of the book of Kees Waaijman about spirituality.
Mihkelson, Immo, 1959-
Uutest plaatidest Mike Oldfield "Collection", Compay Segundo "Duets", Sandra "Wheel Of Time", "Spirit Of Africa", Paddy's "Irish Folk", Edwin Collins "Doctor Syntax", Doors "Live in Hollywood", Sonic Youth "Murray Street"
Коовит, Кая, 1968-
10 kõige enam teenivat Hollywoodi näitlejat (Quigley Publishing' andmeil) on Denzel Washington, Shia LaBeouf, Brad Pitt, Meryl Streep, Tom Hanks, Robert Downey jr., George Clooney, Matt Damon, Johnny Depp ja Sandra Bullock
Laaniste, Mari, 1977-
Rahvusvaheline grupinäitus "Loomakari" Tallinna Kunstihoones kuni 12. aprillini. Kuraator Sandra Jõgeva, kujundaja Tanel Saar. Lühidalt Jenni Juulia Wallinheimo, Kjetil Kauslandi ja Loore Emilie Raavi töödest
... Geovette E. Washington, Deputy General Counsel Office of the Chief Financial Officer and Assistant..., Chief Financial Officer and Director for Administration Economics and Development Administration Thomas Guevara, Deputy Assistant Secretary for Regional Affairs Sandra Walters, Chief Financial Officer and...
Püha Lucia ehk luutsinapäeval kroonitakse heade jõulude kehastaja ja soojuse ning valguse tooja Lucia. Krooni valmistas Rootsi suursaatkonna algatatud konkursi võitja Sandra Savelli Eesti Kunstiakdeemiast
. Richard Matzopoulos, Ashley van Niekerk, Sandra Marais, Hilton Donson. A Qualitative Evaluation of Medico-Legal Services in Gauteng, South Africa: Service Accessibility and Quality of Care to Rape Survivors. Shahnaaz Suffla, Mohamed ...
Randviir, Ave, 1981-
Näitus "Leave like a Lady" Draakoni galeriis, autorid Sandra Jõgeva & Kristin Kalamees, "Paradiis" Hobusepea galeriis, autor Marianne Männi ja "Väikeloomade surnuaed" HOP galeriis, autorid Ester Faiman ja Argo Männik
Full Text Available ... you, Boston Children's is a place where we can write the greatest children's stories ever told. Sandra ... and CEO Connect with Boston Children's Hospital How can we help? Close How can we help? Request ...
... the collections, to Sandra Johnston, Program Analyst, Office of Financial Assistance, Small Business... Premier Certified Lenders Program (PCLP) transfers considerable authority and autonomy to Premier...) that are held in account at financial institutions and about SBIC borrowings from financial...
Pels, Ruta, 1960-
Eesti kunsti õhtutest Suurbritannia saadiku residentsis Tallinnnas, partneriks La Galerie Passage. Iga kuu muutuvas kunstikollektsioonis olevatest eesti kunstnike töödest (Rein Tammik, Malle Leis, Sandra Jõgeva jt.)
... Equity Investors V, L.P. 20110468 G New Generations Trust; Thomas and Dafna Kaplan; New Generations Trust... Corporation; Exxon Mobil Corporation; TSRC Corporation. FOR FURTHER INFORMATION CONTACT: Sandra M. Peay...
Full Text Available Review of Kinship and Beyond: The Genealogical Model Reconsidered. Sandra Bamford and James Leach, eds. 2009. Berghahn Books, New York. 292 pp., 21 illustrations, bibliography, index. $95.00 (hardback. ISBN 9781845454227.
Hanson, Raimu, 1957-
Kunstirühmituse Pink Punk (Sandra Jõgeva, Kristin Kalamees, Aino Ingrid Sepp, Kaarel Sammet) näitusest Y-galeriis. Lähemalt videoinstallatsioonist "Must turg" ja ruumiinstallatsioonist "Elulähedane kogemus"
... Logistics, Inc., February 13, 2010. One Cross Island Plaza, Suite 203-G, Rosedale, NY 11422. 018250F.... 021870N AKM International, LLC, 301 February 19, 2010. Varick Street, Jersey City, NJ 07302. Sandra L...
... Customs October 28, 2011. Brokers, 1386 Salford, Houston, TX 77032. 017582F Trans Global Logistics, Inc., 1 Conan Drive, Midland City, AL 36350. Sandra L. Kusumoto, Director, Bureau of Certification and...
Verrev, Toomas, 1979-
I Eesti Koomiksibiennaal Kultuuritehase Polymer Kunstikonteineris Tallinnas 16. aprillist 23. maini. Kuraatorid Elisabeth Salmin ja Sandra Jõgeva. Esitleti Ed Labetski ja Ago Visaki koomiksit "Kalevipoeg" ning Elisabeth Salmini koomiksikogumikku "Simulant ja teised"
Караев, Николай, 1978-
Eesti I Koomiksibiennaal Kultuuritehase Polymer Kunstikonteineris Tallinnas alates 16. aprillist. Kuraatorid on Elisabeth Salmin ja Sandra Jõgeva. Esitletakse kollektiivselt loodud kunstnikuraamatut "Comic Magazine", toimub kirjanduslike kohtumiste seeria "Üks hullem kui teine" koomiksieri
.... Forshay or Sandra E. Safro, Sutherland Ashbill & Brennan LLP, 1275 Pennsylvania Avenue, Washington [email protected]sutherland.com , [email protected]sutherland.com or [email protected]sutherland.com . There are two ways...
.... Reading Toni Morrison's The Bluest Eye and Sandra Cisneros' The House on Mango Street in a comparative context allows an investigation of parallel identity issues that are represented through cultural specificity.
... Dependable International Services 12574 New Orleans. and Transport, Inc.. Professional Customs Brokers, Inc.... Horizon Logistics, LLC 28432 Dallas. Sandra L. Smith 15266 Dallas. Barry E. Booth 09627 San Francisco...
Monica, Calif.: RAND Corporation, MG-662-OSD, 2008. As of May 21, 2014: http://www.rand.org/pubs/monographs/MG662.html de Sa, Joia , Sandra Mounier...Hanvoravongchai, Piya, Wiku Adisasmito, Pham Ngoc Chau, Alexandra Conseil, Joia de Sa, Ralf Krumkamp, Sandra Mounier-Jack, Bounlay Phommasack...This work should be of interest to CBEP and CTR leadership as they seek to improve program design , budget allocation, and execution and to
negotiators to move beyond an impasse.108 Don’t be so ready to chase revolutionary designs over evolutionary designs. A key lesson from Russian...112 2002 Oct. 7 2002 Oct. 18 9A S1 truss delivery Jeffrey S. Ashby, Pamela A. Melroy, David A. Wolf, Piers J. Sellers, Sandra H. Magnus , Fyodor...2002 Oct. 18 9A S1 truss delivery Jeffrey S. Ashby, Pamela A. Melroy, David A. Wolf, Piers J. Sellers, Sandra H. Magnus , Fyodor N. Yurchikhin
Marston, Gemma; Winder, Steve J
In addition to their nutritional value, processed soy bean extracts contain several activities with potential therapeutic benefits. These include anti-oxidants, and tyrosine kinase and protease inhibitory activity. There are also anecdotal reports of health benefits of soy products in alleviating DMD symptoms. Mdx mice were fed a control soy-free diet or the same diet containing either a proprietary soy preparation (Haelan 951), purified soy isoflavones, purified Bowman-Birk protease inhibitor or a combination of isoflavones and Bowman-Birk inhibitor. Mice were tested for their wire hanging ability at the start of the diet regimen and every 4 weeks until week 12 of treatment. The diet containing Bowman-Birk inhibitor was the only one to show a significant and sustained improvement over the 12 weeks of the study. All other dietary additions; Haelan 951, isoflavones and isoflavones with Bowman-Birk inhibitor, were not significantly different from each other or from control. The effectiveness of Bowman-Birk inhibitor in mdx mice clearly warrants further study.
Schulte, Kevin; Berger, Katja; Boor, Peter; Jirak, Peggy; Gelman, Irwin H; Arkill, Kenton P; Neal, Christopher R; Kriz, Wilhelm; Floege, Jürgen; Smeets, Bart; Moeller, Marcus J
Parietal podocytes are fully differentiated podocytes lining Bowman's capsule where normally only parietal epithelial cells (PECs) are found. Parietal podocytes form throughout life and are regularly observed in human biopsies, particularly in atubular glomeruli of diseased kidneys; however, the origin of parietal podocytes is unresolved. To assess the capacity of PECs to transdifferentiate into parietal podocytes, we developed and characterized a novel method for creating atubular glomeruli by electrocoagulation of the renal cortex in mice. Electrocoagulation produced multiple atubular glomeruli containing PECs as well as parietal podocytes that projected from the vascular pole and lined Bowman's capsule. Notably, induction of cell death was evident in some PECs. In contrast, Bowman's capsules of control animals and normal glomeruli of electrocoagulated kidneys rarely contained podocytes. PECs and podocytes were traced by inducible and irreversible genetic tagging using triple transgenic mice (PEC- or Pod-rtTA/LC1/R26R). Examination of serial cryosections indicated that visceral podocytes migrated onto Bowman's capsule via the vascular stalk; direct transdifferentiation from PECs to podocytes was not observed. Similar results were obtained in a unilateral ureter obstruction model and in human diseased kidney biopsies, in which overlap of PEC- or podocyte-specific antibody staining indicative of gradual differentiation did not occur. These results suggest that induction of atubular glomeruli leads to ablation of PECs and subsequent migration of visceral podocytes onto Bowman's capsule, rather than transdifferentiation from PECs to parietal podocytes.
This Tank Sampling and Analysis Plan (TSAP) identifies sample collection, laboratory analysis, quality assurance/quality control (QA/QC), and reporting objectives for the characterization of tank 241-AW-104 waste. Technical bases for these objectives are specified in the 242-A Evaporator Data Quality Objectives (Bowman 2000a and Von Bargen 1998), 242-A Evaporator Quality Assurance Project Plan (Bowman 1998 and Bowman 2000b), Tank 241-AW-104 Sampling Requirements in Support of Evaporator Campaign 2000-1 (Le 2000). Characterization results will be used to support the evaporator campaign currently planned for early fiscal year 2001. No other needs (or issues) requiring data for this tank waste apply to this sampling event
Pabst, R.; Sterzel, R.B.
Normal adult Sprague-Dawley rats received either a single or repetitive injection of the DNA precursor 3 H-thymidine ( 3 H-TdR). For autoradiography semi-thin sections were prepared 2 hr to 14 days after labeling. The majority of labeled cells noted in glomerular tufts were endothelial cells. Mesangial cells had a lower production rate. Podocytes revealed no evidence of proliferation. Bowman's capsule cells showed a higher labeling index than tuft cells at all times. Neither the urinary nor the vascular pole was found to be a proliferative zone for Bowman's capsule cells. The flash and repetitive labeling experiments demonstrated a constant rate of cell renewal of about 1% per day, resulting in a long life span for endothelial and mesangial cells as well as Bowman's capsule cells. These data provide a basis for cell kinetic studies in models of glomerular diseases
Full Text Available Akira Kobayashi, Tomomi Higashide, Hideaki Yokogawa, Natsuko Yamazaki, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Objective: To report the in vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta (OI with special attention to the abnormality of Bowman's layer and sub-Bowman's fibrous structures (K-structures. Patients and methods: Two patients (67-year-old male and his 26-year-old son with OI type I were included in this study. Slit lamp biomicroscopic and in vivo laser confocal microscopic examinations were performed for both patients. Central corneal thickness and central endothelial cell density were also measured. Results: Although the corneas looked clear with normal endothelial density for both eyes in both patients, they were quite thin (386 µm oculus dexter (OD (the right eye and 384 µm oculus sinister (OS (the left eye in the father and 430 µm OD and 425 µm OS in the son. In both patients, slit lamp biomicroscopic and in vivo laser confocal microscopic examination showed similar results. Anterior corneal mosaics produced by rubbing the eyelid under fluorescein were completely absent in both eyes. In vivo laser confocal microscopy revealed an absent or atrophic Bowman's layer; a trace of a presumed Bowman's layer and/or basement membrane was barely visible with high intensity. Additionally, K-structures were completely absent in both eyes. Conclusion: The absence of K-structures and fluorescein anterior corneal mosaics strongly suggested an abnormality of Bowman's layer in these OI patients. Keywords: osteogenesis imperfecta, K-structure, confocal microscopy, Bowman's layer
repair defects asso- ciated with downstream mediators of the HR reaction (e.g., XRCC2, BRCA2, or PALB2) (Bouwman et al., 2010; Bowman- Colin et al., 2013...and BRCA-mutated breast cancers. Nat. Struct. Mol. Biol. 17, 688–695. Bowman- Colin , C., Xia, B., Bunting, S., Klijn, C., Drost, R., Bouwman, P., Fine...chromosomes. It is thus surprising that cells use ‘quick and dirty ’ repair by NHEJ rather than the slower, more accurate repair by homologous recombination
Networking Organizational Issues Authors: Bruce J. West Ph.D. Army Research Office Elizabeth K. Bowman Ph.D. Army Research Laboratory – Human...Contact: Elizabeth K.Bowman AMSRD-ARL-HR Bulding 459, Aberdeen Proving Ground, MD 21005 410-278-5924 EBowman@arl.army.mil 1 Report Documentation Page...L.E. Brus , Nature 383, 802 (1996); M. Kuno, D.P. Fromim, s.R. Hohmson, A. Gallagher and D.J. Nesbitt, Phys. Rev. B 67, 125304 (2003); K.R. Shimizu
EDITORIAL Teoria do documentário ---> Marcius Freire, Manuela Penafria DOSSIER TEMÁTICO Novos territórios do documentário ---> Arlindo Machado Perspectivas da análise narrativa no cinema: por uma abordagem da narrativa no filme documentário ---> Sandra Straccialano Coelho Fotografía y realidad: notas para una fenomenología del cine documental ---> Rubén Dittus Retórica e pragmática do documentário: a experiência de realização cinematográfica compartilhada do projeto Vídeo nas Aldeias
Juliano José de Araújo Juliano José de Araújo Juliano José de Araújo
Full Text Available The article examines the experience of shared filmmaking (preparation,shooting and editing of the Brazilian Project Video in the Villages from the analysis ofthree documentaries directed by indigenous filmmakers. It analyzes the rhetoric choices ofthe documentaries, as the mise en scène, the first person narration and the voice-over etc.,according to their rhetoric and pragmatic dimensions, as defined by Plantinga (1997.
Preisser, Felix; Bandini, Marco; Mazzone, Elio; Nazzani, Sebastiano; Marchioni, Michele; Tian, Zhe; Saad, Fred; Pompe, Raisa S; Shariat, Shahrokh F; Heinzer, Hans; Montorsi, Francesco; Huland, Hartwig; Graefen, Markus; Tilki, Derya; Karakiewicz, Pierre I
Accurate life expectancy estimation is crucial in clinical decision-making including management and treatment of clinically localized prostate cancer (PCa). We hypothesized that Social Security Administration (SSA) life tables' derived survival estimates closely follow observed survival of PCa patients. To test this relationship, we examined 10-yr overall survival rates in patients with clinically localized PCa and compared it with survival estimates derived from the SSA life tables. Within the Surveillance, Epidemiology, and End Results database (2004), we identified patients aged >50-patients who did not die of disease or other causes. Monte Carlo method was used to define individual survival in years, according to the SSA life tables (2004-2014). Subsequently, SSA life tables' predicted survival was compared with observed survival rates in Kaplan-Meier analyses. Subgroup analyses were stratified according to treatment type and D'Amico risk classification. Overall, 39191 patients with localized PCa were identified. At 10-yr follow-up, the SSA life tables' predicted survival was 69.5% versus 73.1% according to the observed rate (ppatients. Conversely, the smallest differences were recorded for external beam radiotherapy (1.7%) and unknown treatment type (1.6%) patients. Overall, SSA life tables' predicted life expectancy closely approximate observed overall survival rates. However, SSA life tables' predicted rates underestimate by as much as 9.1% the survival in brachytherapy patients, as well as in D'Amico low-risk and radical prostatectomy patients. In these patient categories, an adjustment for the degree of underestimation might be required when counseling is provided in clinical practice. Social Security Administration (SSA) life tables' predicted life expectancy closely approximate observed overall survival rates. However, SSA life tables' predicted rates underestimate by as much as 9.1% the survival in brachytherapy patients, as well as in D'Amico low
Østby-Deglum, Marie; Brennhovd, B.; Axcrona, K.
Objective. Erectile function with and without use of erectile aids was compared in high-, intermediate- and low-risk prostate cancer patients at a mean of 3 years after robot-assisted laparoscopic prostatectomy (RALP). Materials and methods. A sample of 982 men who underwent RALP at Oslo University...... according to the preoperative D'Amico classification. Based on questionnaire data, two primary outcomes were defined: ability to have intercourse (sufficient erection), and use and effect of erectile aids. Results. Sufficient erection with or without erectile aids was reported by 19% of the high-, 30...
dam/lockheed/data/isgs/documents/LMCSA%20Ov erview%20Fact%20Sheet_Final%20%282%29. pdf Lunt, Barry, Joseph J. Ekstrom, Sandra Gorka, Gregory Hislop ...Electronics Engineers, 2006, p. 33. 21 Barry Lunt, Joseph J. Ekstrom, Sandra Gorka, Gregory Hislop , Reza Kamali, Eydie Lawson, Richard LeBlanc, Jacob Miller...1 (January 1980 ). 106 Daft, 2008, p. 17. 107 Gerald D. Bell, “Determinants of Span of Control,” American Journal of Sociology 73, no. 1 (1967
Fil: Di Stéfano, Mariana. Universidad Nacional de las Artes. Área Transdepartamental de Crítica de Artes. Instituto de Investigación y Experimentación en Arte y Crítica; Argentina Fil: Sánchez, Sandra. Universidad Nacional de las Artes. Área Transdepartamental de Crítica de Artes. Instituto de Investigación y Experimentación en Arte y Crítica; Argentina Fil: Sánchez, Sandra. Universidad de Ciencias Empresariales y Sociales; Facultad de Ciencias de la Comunicación; Argentina. Fil: Di ...
Meijer, M.M.T.; Spekking, W.T.J.; Sijtsma, L.; Bont, de J.A.M.
Proteinaceous protease inhibitors, Kunitz Soybean Trypsin Inhibitor (KSTI) and Bowman Birk Inhibitor (BBI), in legume seeds reduce the digestibility of proteins in feed of monogastric animals. Enzymatic inactivation of these inhibitors will increase the nutritional value of the feed. The aim of this
... & Gas Corporation (Meshoppen Creek), Lemon Township, Wyoming County, Pa. Renewal of surface water... settlement involving a water resources project; (2) approved or tabled the applications of certain water... & Gas Corporation (Bowman Creek), Eaton Township, Wyoming County, Pa. Renewal of surface water...
National Centre for Vocational Education Research (NCVER), 2015
This good practice guide is intended to assist public and private registered training organisations (RTOs) planning to commence higher education (HE) delivery. The guide is based on research undertaken by Victor Callan and Kaye Bowman, who completed case studies with six providers currently delivering higher education qualifications in addition to…
equipped with a thermal con- ductivity detector (TCD) with a CTR1 column ( Alltech Associates Inc., Deerfield, IL) with He as carrier gas. The injection...grow at this pH (Bowman, 2006). Ama- ral and Knowles (1995) reported that Type II methanotrophs had a competitive advantage when oxygen was limited and
.../or HHS Co-Executive Secretary, 2015 DGAC: Kellie (O'Connell) Casavale, Ph.D., RD; Office of Disease...; Telephone: (703) 305-7600; Fax: (703) 305-3300. USDA Co-Executive Secretary, Shanthy A. Bowman, Ph.D..., which includes physical activity; nutrient bioavailability; nutrition biochemistry and physiology; food...
... Alternate Designated Federal Officer, 2015 DGAC: Kellie (O'Connell) Casavale, Ph.D., RD; Office of Disease...; Telephone: (703) 305-7600; Fax: (703) 305-3300. USDA Co-Executive Secretary, Shanthy A. Bowman, Ph.D...; nutrient bioavailability; nutrition biochemistry and physiology; food processing science, safety and...
Graue, Elizabeth; Ryan, Sharon; Wilinski, Bethany; Northey, Kaitlin; Nocera, Amato
Background/Context: Early childhood education joined the standards movement in 2002 with the Good Start, Grow Smart initiative (Brown, 2007), with advocates arguing that standards were a tool for creating more continuity and coherence in PreK systems (Bowman, 2006; Kagan 2012). Critics posed concerns about a perceived poor fit between…
of Catharanthus roseus possessing Mendelian inheritance. Renu Kumari, Vishakha ...... Bowman J. L. 2004 Class III HD-Zip gene regulation, the golden fleece of .... Arabidopsis has multiple effects on plant development, includ- ing early flowering and .... germination is revealed by the misexpression of a homologous gene ...
Callahan, Victor J.; Bowman, Kaye
This good practice guide is based on the report "Industry Restructuring and Job Loss: Helping Older Workers Get Back into Employment" by Victor J. Callan and Kaye Bowman. The aim of the research was to identify evidence-based practices that led to successful skills transfer, re-skilling, training and the attainment of new jobs for older…
SST. 1), placed between the SW1 and ML2 is used to minimize the reflection of power from the matched load (Bowman 1975). The phase of the pumping power can be modulated by the “phase modulator” shown in the dotted box in the ...
Panampunnayil, S.U.; Viswakumar, M.
to S. servatus Fage (1925) known from Zanzibar and S. cardisomae Bowman (1973) known from Mexico in many of its characters, notably in having separate eye- plates with visual elements and in the apical arma- ture of the telson. But S. cochinensis...
Jul 12, 2012 ... E-mail: email@example.com, firstname.lastname@example.org. Tel: +98 ... Stewart, 1997; Van Esbroeck and Bowman, 1998; Kumar et al., 2003 ..... Isabel N, Tremblay L, Michaud M, Tremblay FM, Bousquet J (1993). RAPDs as an aid to ...
R.E. Kleinman, Electromagnetic and (Raleigh- Ritz ), Galerkins method, and the method of Acoustic Scattering by Simple Shapes, J.J. Bowman, least...71 C. Namislo, "Analysis of mobile radio slotted ALOHA networks," IEEE the M. Barry Carlton Award for best paper from the IEEE Aerospace and Tram
Charging of Large Spwc Structure• . in Polut Otbil.’" Prweedings of thre Air For’e Grespykirs fitrano, W4r4 nop em Natural Charging of large Space Stru, ures...3, p. 1433- 1440, 1991. Bowman, C., Bogorad, A., Brucker, G., Seehra, S., and Lloyd, T., "ITO-Coated RF Transparent Materials for Antenna Sunscreen
Vacc, Nicholas A.
Because cancer patients and their families have special psychological needs that are not always met through medical care, the Bowman Gray School of Medicine at Wake Forest University established the Cancer Patient Support Program (CPSP) at the Oncology Research Center. Services provided by the CPSP's 2 professional counselors and approximately 35…
W. Moriarty, B. Eiteneer, M. Goldenberg, C. T. Bowman, R. K. Hanson, S. Song, W. C. Gardiner, V. V. Lissianski, Z. Qin, GRI -Mech 3.0. Available at...http://www.me.berkeley.edu/ gri mech/.  G. Blanquart, CaltechMech v2.1. Available at http://theforce.caltech.edu/resources/.  B. Savard, B
Couchman, J R; Beavan, L A; McCarthy, K J
The extracellular matrix has an integral role in development, homeostasis and pathology of the glomerulus. Three spatially distinct matrices are present in the glomerulus: the mesangium, and basement membranes of the capillary loops and Bowman's capsule. Each is dominated by basement membrane com...
Smeets, B.; Uhlig, S.; Fuss, A.; Mooren, F.; Wetzels, J.F.M.; Floege, J.; Moeller, M.J.
Cellular lesions form in Bowman's space in both crescentic glomerulonephritis and collapsing glomerulopathy. The pathomechanism and origin of the proliferating cells in these lesions are unknown. In this study, we examined proliferating cells by lineage tracing of either podocytes or parietal
Miesen, L.; Steenbergen, E.; Smeets, B.
In normal glomeruli, parietal epithelial cells (PECs) line the inside of Bowman's capsule and form an inconspicuous sheet of flat epithelial cells in continuity with the proximal tubular epithelial cells (PTECs) at the urinary pole and with the podocytes at the vascular pole. PECs, PTECs and
McKeown, Mary P.
Reviews two papers appearing in this "Economics of Education Review" issue. Faults M.J. Bowman, B. Millot, and E. Schiefelbein's tax burden study for excluding background information on educational goals in France, Chile, and Malaysia. Criticizes L. R. Jones, F. Thompson, and W. Zumeta for viewing budgeting as limiting expenditures, rather than…
The importance of "belonging" for college students has been well documented. Students' sense of belonging is closely related to their academic achievement, retention, engagement, satisfaction with student life, mental health, and overall well-being (Astin, 1993; Baumeister & Leary, 1995; Bowman, 2010; Hausmann, Schofield, &…
The University of Melbourne's Middle Eastern Manuscript collection housed at the Baillieu Library was acquired by Professor John Bowman in the 1950s as part of a teaching collection to promote greater learning of Middle Eastern culture and civilisation (Pryde 2007, 3). The collection is a rare example within Australia and represents many different…
Heart disease is among the leading causes of death worldwide. Combined with stroke, it accounts for one in three deaths. Improving heart health could save millions of lives each year. In this podcast, Dr. Barbara Bowman discusses ways to prevent heart problems.
Learning Point Associates / North Central Regional Educational Laboratory (NCREL), 2005
Besides a change in the expectations of parents, other shifts are occurring in society that impact the youngest children (Bowman, Donovan, & Burns, 2000): (1) More women are in the workforce than ever before, which means more children are in child care or preschool; (2) There is increasing evidence of, and conviction from educators, that preschool…
In March 2016, representatives from Australian Science Teachers Association (ASTA) were invited to BHP Billiton's head office in Melbourne, Australia, to listen to astronautical engineer and NASA New Horizons Mission Operations Manager Alice Bowman discuss her career trajectory and the role her choices in education played in her success. Alice…
Heart disease is among the leading causes of death worldwide. Combined with stroke, it accounts for one in three deaths. Improving heart health could save millions of lives each year. In this podcast, Dr. Barbara Bowman discusses ways to prevent heart problems. Created: 10/2/2014 by MMWR. Date Released: 10/2/2014.
Wyble, Brad; Potter, Mary C.; Bowman, Howard; Nieuwenstein, Mark
Is one's temporal perception of the world truly as seamless as it appears? This article presents a computationally motivated theory suggesting that visual attention samples information from temporal episodes (episodic simultaneous type/serial token model; Wyble, Bowman, & Nieuwenstein, 2009). Breaks
Jan 30, 2015 ... 2. Bowman RM, Boshnjaku V, McLone DG. The changing incidence of myelomeningocele and its impact on pediatric neurosurgery: a review from the Children's Memorial Hospital;. Child's nervous system: ChNS: official journal of the. International Society for Pediatric. Neurosurgery. 2009. Jul;25(7):801-6.
Berger, K.; Schulte, K.; Boor, P.; Kuppe, C.; Kuppevelt, T.H. van; Floege, J.; Smeets, B.; Moeller, M.J.
Previously, we showed that some podocytes in juvenile mice are recruited from cells lining Bowman's capsule, suggesting that parietal epithelial cells (PECs) are a progenitor cell population for podocytes. To investigate whether PECs also replenish podocytes in adult mice, PECs were genetically
Couchman, J R; Abrahamson, D R; McCarthy, K J
-CSPG was only strongly expressed in the vasculature invading late comma stage glomeruli, and later in presumptive and mature Bowman's capsule. Over the first six to eight weeks, the capillary basement membranes contained BM-CSPG, but in gradually decreasing amounts until it became completely undetectable...
Histologically, the architecture of the kidneys in the experimental animals treated with pumpkin root extract orally and intraperitoneally showed enlarged tubules, distorted glomeruli and Bowman's capsule, shrinking of proximal and distal convoluted tubules compared with the control. These results suggest that the root of ...
Full Text Available In 6 patients with iron deficiency anemia the proliferation of epi, thelial cells of glomeruli were prominent associated with edema and adherence of Bowman's capsule in kidney biopsy, the cause of proliferation is not known.
International IRCOBI Conference on the Biomechanics of Impacts: 251-264. Bowman, B.M., and Robbins , D.H. (1972) Parameter Study of Biomechanical Quantities in...International IRCOBI Conference on the Biomechanics of Impacts: 109-125. 45 Jones, J.A., Hart, S.F., Baskin , D.S., Effenhauser, R., Johnson, S.L
Kevin C. Ryan; Cassandra Koerner
Fire is a natural component of earth's ecosystems. Fire has impacted most landscapes of the Americas, having left evidence of its passing in trees, soils, fossils, and cultural artifacts (Andreae 1991; Benton and Reardon 2006; Biswell 1989; Bowman and others 2009; Boyd and others 2005; Cochrane and others 1999; DeBano and others 1998; Jurney and others 2004;...
Full Text Available Aim: improvement of early diagnostics of prostate cancer by developing a technique, which makes possible to predict its clinical significance in outpatient setting before initiation of invasive procedures. Material and Methods. Clinical data of 398 patients who underwent transrectal prostate biopsy in 2012-2014 in SSMU S. R. Mirotvortsev Clinical Hospital, was used to build an artificial neural network, while its output allowed to determine whether the tumour corresponds to Epstein criteria and which D'Amico risk group it belongs to. Internal validation was performed on 80 patients, who underwent prostate biopsy in September 2014 — December 2014. Sensitivity, specificity, positive and negative predictive value of artificial neural network were calculated. Results. Accuracy of predicting adenocarcinoma presence in biopsy specimen was 93,75%; accuracy of predicting whether the cancer meets active surveillance criteria was 90%. Accuracy of predicting T stage (T1c, T2a, T2b, T2cwas 57,1%. Prediction of D'Amico risk group was accurate in 70% of cases; for low-risk cancer accuracy was 81,2%. Conclusion. Artificial neural networks may be responsible for prostate cancer risk stratification and determination of its clinical significance prior to biopsy.
Bariety, Jean; Mandet, Chantal; Hill, Gary S; Bruneval, Patrick
Although parietal podocytes along the Bowman's capsule have been described by electron microscopy in the normal human kidney, their molecular composition remains unknown. Ten human normal kidneys that were removed for cancer were assessed for the presence and the extent of parietal podocytes along the Bowman's capsule. The expression of podocyte-specific proteins (podocalyxin, glomerular epithelial protein-1, podocin, nephrin, synaptopodin, and alpha-actinin-4), podocyte synthesized proteins (vascular endothelial growth factor and novH), transcription factors (WT1 and PAX2), cyclin-dependent kinase inhibitor p57, and intermediate filaments (cytokeratins and vimentin) was tested. In addition, six normal fetal kidneys were studied to track the ontogeny of parietal podocytes. The podocyte protein labeling detected parietal podocytes in all of the kidneys, was found in 76.6% on average of Bowman's capsule sections, and was prominent at the vascular pole. WT1 and p57 were expressed in some parietal cells, whereas PAX2 was present in all or most of them, so some parietal cells coexpressed WT1 and PAX2. Furthermore, parietal podocytes coexpressed WT1 and podocyte proteins. Cytokeratin-positive cells covered a variable part of the capsule and did not express podocyte proteins. Tuft-capsular podocyte bridges were present in 15.5 +/- 3.7% of the glomerular sections. Parietal podocytes often covered the juxtaglomerular arterioles and were present within the extraglomerular mesangium. Parietal podocytes were present in fetal kidneys. Parietal podocytes that express the same epitopes as visceral podocytes do exist along Bowman's capsule in the normal adult kidney. They are a constitutive cell type of the Bowman's capsule. Therefore, their role in physiology and pathology should be investigated.
+27 (18) 299-2508; e-mail: email@example.com .... After 5 min exposure, an inverted light microscope was used to ..... Light microscopy images of C. hirundinella cells in source water (a) and the effects of chlorine concentrations after exposure to chlorine .... trations of organic carbon compounds measured during dif-.
Kunstnik Sandra Jõgeva korraldab Tallinnas kultuuritehases Polymer alternatiivgaleriis Non Grata Kunstikonteiner kirjanduslike kohtumiste seeria "Üks hullem kui teine". Kirjandusüritused ei ole mõeldud ainult oma ala insider'itele. 17. juulil esinevad Armin Kõomägi teemal "Kirjandus ja äri", Andrus Elbing "Vangla sinus eneses" jt. Vt. ka Looming, 2008, nr. 8, lk. 1271
Kunstnikud Krista Rambak (24), Sandra Jõgeva (26) ja Kristin Kalamees (24) avasid moodsa kunsti seletamiseks kunstitelefoni, millele helistades on 24 tundi ööpäevas võimalik küsida nõu kunstiküsimustes. Projekti kaasosaline ja flaieri kujundaja Margus Tamm
In this article, Sandra Wentworth invites science teachers to ask a group of students to write the names of three famous scientists on a piece of paper within one minute. Chances are that most students will mention Einstein and be unable to name another scientist, specifically a woman, except for an occasional Marie Curie response. This article…
Influence of vermicompost humic acid on chlorophyll content and acclimatization in banana clone, Enano Guantanamero. Marcia Beatriz Moya Fernández, Esteban Sánchez Chávez, Daniel Cabezas Montero, Andrés Calderín García, Dany Marrero López, Eduardo F. Héctor Ardisana, Sandra Pérez Álvarez ...
Veispak, Teet, 1955-
Näitusest "Kehaturg" Tallinna Kunstihoones, kuraator Reet Varblane. Liina Siibi videost "Vastumeelne keha", soome kunstniku Teemu Mäki väljapanekust "Prostitutsioonist", malaisia fotograafi Diana Lui fotoseeriast, rootsi-eesti fotograafi Bie Erenurme väljapanekust "Mu ema on lits", Sandra Jõgeva näitusel eksponeeritud šokolaadiümbristest
COLORATION Sandra Duchêne From September 5 to 16, 2016 CERN Meyrin, Main Building La recherche de l’Universel. Après tout ! C’est de l’Amour ! What else to say ? …La couleur, l’ENERGIE de la vie…
Tallinna Ülikooli Konfutsiuse Instituudi neli õppejõudu - Zhuoya Wu, Xiuping Huang, Sandra Sainio ja Kristiina Kraft viisid Kolga koolis toimunud Hiina päeval läbi töötubasid ja loenguid hiina keelest ja kultuurist
French, Lydia A.
This essay intervenes in contemporary scholarship on Sandra Cisneros's "Woman Hollering Creek" (1991) by examining the canciones she uses as epigraphs and their relationship to the multiple nationalisms that Chicana/os actively negotiate. I argue that Cisneros's decision to include powerfully nationalist Mexican cancion traditions…
José Eduardo Rueda Enciso
Chajeradó, el río de la caña flecha partida. Luz Marcela Duque, Iván Darío Espinosa, Afda Cecilia Gálvez, Diego Herrera y Sandra María Turbay. Premios Nacionales Colcultura 1996, Colcultura, Bogotá, 1997, 477 págs.
Tallinna Ülikooli Matemaatika ja Loodusteaduste Instituudis töötab uurimisrühm, kelle huvi on seotud organismis toimuva raua ainevahetuse ning selle häirete tagajärjel ilmnevate haiguslike protsessidega, mille hulka kuulub ka Alzheimeri tõbi. Teadusprojekte juhivad Tiit Land ja Sandra Zetterström Fernaeus
van Otterloo, S.G.
Veel ouders zijn in staat hun kleuters thuis deelvaardigheden van lezen en spellen aan te leren. Ook bij kinderen met een erfelijk risico op dyslexie. Sandra van Otterloo onderzocht de effectiviteit van een thuistraining die speciaal ontwikkeld is voor deze doelgroep. Een steekproef uit deze
... DEPARTMENT OF THE TREASURY Office of Thrift Supervision [AC-48 OTS Nos. 03912 and H4739] Bank of..., 2010, the Office of Thrift Supervision approved the application of Bank of Ruston, Ruston, Louisiana.... Dated: August 11, 2010. By the Office of Thrift Supervision. Sandra E. Evans, Federal Register Liaison...
... Office of Thrift Supervision approved the application of Oneida Financial, MHC and Oneida Savings Bank... DEPARTMENT OF THE TREASURY Office of Thrift Supervision [AC-44: OTS No. H-4704] Oneida Financial... of Thrift Supervision. Sandra E. Evans, Federal Register Liaison. [FR Doc. 2010-13209 Filed 6-2-10; 8...
Screen break: nursing students Jackie Walsh, Laura Robinson and Liz Midgley join 'matron' Sandra McQuat, a ward manager at Beatson Oncology Centre, the Western Infirmary, Glasgow, as they try out nurse training 1950s style for a new BBC series to be televised this autumn. The series, Thoroughly Modern Matron, was filmed at Belvoir Park Hospital, Belfast.
EKA interdistsiplinaarsete kunstide eriala magistritööde näitus "Nagu aamen kirikus". Eksponeeritud Kristin Kalamehe lühimängufilm "Igavene tuli", Mirja-Mari Smidti video ja maaliseeria "Kaaluta olek", Allan Tõnissoo videoskulptuur "Kristus", Avangardi (Sandra Jõgeva, Margus Tamm) fotoseeria ja video "Sõda ja rahu". Avamisel Avangardi performance
van Tongeren, Sandra P.
Bij lange, bemande ruimtemissies, bijvoorbeeld naar Mars, kan gevaar schuilen in de kleinste hoekjes. Dat blijkt uit het promotieonderzoek van Sandra van Tongeren. Zij stelt onder meer vast dat al bij kortdurende ruimtemissies opmerkelijke veranderingen optreden in de hoeveelheden en soorten
Smith, Colin Bridges
Apartheid created more than physical distances between color groups; South Africa is made up of people with often separated minds. Leaders of the democratic government draw from and modify the ancient African tribal value called "ubuntu" as the philosophic basis for their cultural strategy of unification. Sandra Chait has pointed out…
Full Text Available Tina Freyburg, Sandra Lavenex, Frank Schimmelfennig, Tatiana Skripka and Anne Wetzel. 2015. Democracy Promotion by Functional Cooperation. The European Union and its Neighbourhood. Challenges to Democracy in the 21st Century. Palgrave Macmillan, UK, 291 pages, ISBN: 978-1-137-48934-0
Sandra Lee Bartky criticises the account of meaning contained in Heidegger's ontology in Being and Time. In her view, Heidegger must choose between the claim that meaning is received and the claim that it is created, but is unable to do so. This paper argues that Bartky's criticism is misconceived, by showing that ...
Takes the position, contrary to that of Sandra Scarr, that the details of socialization patterns are crucial to an understanding of normal and deviant development. Research is cited to support the argument that better than adequate parenting optimizes the development of both normal and vulnerable children and that parents' belief in their own…
Duke) Fort Sam Houston, TX 78234-6200 26 Director of Professional Services U.S. Air Force School AFMSC/GSP of Aerospace Medicina Brooks Air Force Base...Force Base, CA 93523-5000 Commander Ms. Sandra G. Hart Code 3431 Ames Research Center Naval Weapons Center MS 229-S China Lake, CA 93555 Moffett Field, CA
.... Chief Financial Officer and Assistant Secretary for Administration, William J. Fleming, Director for... Assistant Secretary for Regional Affairs, Sandra Walters, Chief Financial Officer and Director of..., Robert J. Byrd, Chief Financial Officer/Chief Administrative Officer, NWS, Joseph, F. Klimavicz, Chief...
Kuijk, van S.J.A.
Summary PhD thesis Sandra J.A. van Kuijk
Carbohydrates in plant cell walls are highly fermentable and could be used as a source for ruminant nutrition or biofuel production. The presence of lignin in cell walls hampers the utilization of these carbohydrates and should thus
Croft, W.; van Lier, E.
In this article, the authors present their views on an article by author Sandra Chung related to lexical categories. According to them, Chung's article critiques an analysis of word classes in Chamorro by author Donald M. Topping. They discuss the restatements made by Chung on Topping's criteria for
This document contains three papers presented at a symposium on diversity in the workplace moderated by Sandra Johnson at the 1996 conference of the Academy of Human Resource Development (AHRD). "Diversity and Development: An Assessment of Equal Opportunities and the Role of HRD in the Police Service" (Rashmi Biswas, Penny Dick) examines…
Stanwood, H. Mark; Doolittle, Gini
The concept of sanctuary developed by psychiatrist Sandra Bloom is applied to building safe school cultures. In April 1999, when a group of superintendents in southern New Jersey first assembled to discuss the ramifications of Columbine, the authors had no vision of safe schools, little understanding of the complexities of change, and certainly no…
56. Berliini filmifestivali auhinnasaajad - Jasmila Zhbavici film "Grbavica", Michael Winterbottom ja Mat Whitecross filmi eest "Teekond Guatanamosse" ("The Road to Guantanamo"), Pernille Fischer Christensen filmi "Seep" eest ja Jafar Panahi filmi "Suluseis" eest. Parimad näitlejad olid Sandra Hüller ja Moritz Bleibtreu
Ventsel, Aimar, 1970-
Uutest heliplaatidest "Sandra Sillamaa", "The Concretes", The Juan Maclean "Less Than Human", Joni Mitchell "Songs Of A Prairie Girl", Pedegree "Growing Apart", Shelton San "EP", The Five Corners Quintet "Chasin' The Jazz Gone By", "The Story of Popular Black Music", Foo Fighters "In Your Honor", A "Teen Dance Ordinance"
Esinesid MOKSiga seotud kunstnikud ja rühmitused: John Grzinich, OPA: Slobodanka Stevceska, Denis Saraginovski (Obsessive Possessive Aggression, Makedoonia), Kaarel Vulla, Irene Roos, Jane Remm, OMP: maalikunstnikud Maris Palgi, Eva Orav ja ajakirjanik Maia Möller, Pink Punk: Kristin Kalamees, Margus Tamm, Sandra Jõgeva
... fraud and misuse of city funds, which resulted in a forensic audit investigation, the audited financial...) fiscal year end (FYE), in accordance with the Single Audit Act and OMB Circular A-133. Granted By: Sandra... Waived: The VHA requested a waiver of the audit due date as a result of the State of California...
..., 2012, awarded a new contract to Hayes and Associates. On June 20, 2012, HUD began a forensic audit and... accordance with the Single Audit Act and OMB Circular A-133. Granted By: Sandra B. Henriquez, Assistant..., a contract to perform the Omaha Housing Authority (OHA) audit was awarded to the Reznick Group...
In today's political and global world, it's not enough to remain a solid educational leader; leaders must become advocates for education--on Capitol Hill, in state legislatures, and within communities. In this book, Sandra Whitaker examines key issues facing education, demonstrates methods for unpacking the issues, and discusses strategies to…
While working on a graphic design job at FAO Schwartz, entrepreneurs Sandra Higashi and Byron Glaser recognized a need for something new in toys. The result was the birth of Zolo, an innovative, interactive toy, designed and produced by Higashi and Glaser and distributed by the Museum of Modern Art (MoMA) in New York. The initial idea for Zolo…
Performance'ikunsti ja kunstipärase rokkmuusika ühisfestival "In/Out". Esinevad Tartu Popi & Roki Instituut, Maris Palgi, Eva Orav, Kaie Luik, Maia Möller, Trikotaaž, Enn Tegova, Ruumi Trummid, Fashist Lendas Üle ja Avangard (Sandra Jõgeva & Margus Tamm). Festival päädib Erkki Hüva LP "Varjust rambini" esitlusega
... Logistics LLC (NVO), 9814 Goldenglade Drive, Houston, TX 77064, Officer: Sandra Lesage, Member/Manager... telephone at (202) 523-5843 or by email at [email protected] . ABC Trucking and Logistics L.L.C. (OFF), 3080...), Lawrence R. Lammers, President/CEO, Application Type: License Transfer Atlantic Cargo Logistics LLC (NVO...
Fiftieth Anniversary at the summit : neither fear of heights nor the cold succeeded in cooling the ardour of four brave climbers from CERN who celebrated CERN's 50th Anniversary at the summit of Mount Kilimanjaro (5,895 metres).
On the way back from the summit, Miguel Cerqueira Bastos (AB/PO), David Collados Polidura (IT/GM), Sandra Sequeira Tavares (PH/CMI) and Daniel Cano Ott (n_TOF) raised the official CERN Jubilee flag at 4750 metres altitude.
Oma töid kaitsesid Claudio Julio Rodriguez Higuera, Davi William Ferreira Gomes, Karlina Vaivade, Mohamed Gamal Abdelmeged Elmaayergy, Sigita Tamošauskaite, Eduardo Chávez Herrera, Tyler James Bennett, Felipe Cuervo Restrepo, Julia Popova, Anastasiia Sidielnik, Thomas Mark Boyle, Mirjam Männik, Sandra Preiman, Tamara Stojanovic
Dunn and Dey 1942; Saha 1948, 1952; Saha et al. 1972, 1973). ... nuclei of the Indian landmass (Basu et al. 1981;. Goswami ... Geochemistry. In order to get an idea about petrogenetic process ...... Greenough John D, Fryer Brian J and Robinson Paul T ... 643–660. Mc Mullin David W A, Barr Sandra M and Raeside Robert.
Vare, Kai, 1968-
Radisson SAS hotell Tallinnas on kliendirahulolu-uuringute järgi keti hotellide seas esimeste hulgas. Hotelli direktor Kaido Ojaperv ja müügijuht Ann-Kai Tõrs Radisson SAS-i standarditest, kliendi sajaprotsendilise rahulolu tagamise põhimõtetest, personali valikust, koolitusest. Kommenteerib Sandra Dimitrovich
Jan 2, 2018 ... ... that are going to improve the lives of people in the developing world.” ... and in particular the brain power, can have the biggest impact.” ... IDRC Speakers, from left to right: Robert Hofstede, Sandra Gagnon, Jean Lebel ...
As has been noted by Alvin Goldman, there are some very interesting similarities between his Veritistic Social Epistemology (VSE) and Sandra Harding’s Feminist Standpoint Theory (FST). In the present paper, it is argued that these similarities are so significant as to motivate an incorporation...
additional references.. The material contained in this thesis was compiled from numerous books, magazines, official military records, pamphlets...Reedy Creek Road Raleigh, NC 27607-6410 13. Cynthia E. Williams 318 Petunia Path Chesapeake, VA 2332 5 14. Sandra K. Alston 17409 Park Lane
Lopez, Adalberto, Ed.
Articles in this book cover Puerto Rican history from the Spanish colonization to the present day experience of Puerto Ricans in the United States. Political, social, economic, cultural, and historical issues are addresed by the following authors: Edna Acosta-Belen, Frank Bonilla, Juan Manuel Carrion, Diana Christopulos, Sandra Messinger Cypess,…
... the U.S. Department of the Treasury, Financial Management Service, Financial Accounting and Services..., 2010. Sandra Paylor-Sanders, Acting Director, Financial Accounting and Services Division. [FR Doc. 2010... Bonding Company AGENCY: Financial Management Service, Fiscal Service, Department of the Treasury. ACTION...
Sandra Smidt takes the reader on a journey through the key concepts of Jerome Bruner, a significant figure in the field of early education whose work has spanned almost a century. His wide-ranging and innovative principles of early learning and teaching are unpicked here using everyday language and the links between his ideas and those of other…
Meyerson, Joel W., Ed.; Massy, William F., Ed.
This collection of seven essays from the Stanford Forum for Higher Education Futures focuses on how downsizing, quality management, and reengineering have are affecting higher education. An introductory paper, "Introduction: Change in Higher Education: Its Effect on Institutional Performance," (Joel W. Meyerson and Sandra L. Johnson)…
Tallinna V rahvusvahelise amatöörfilmide festivali peaauhind jagunes nelja filmi vahel, millest üks oli Eesti "Elevanti nägema" (tegijad Sandra Dürdorth, Maureen Apel, Kalev Saar, Leon Shamis). Teised võitjad olid Austria (2 filmi) ja Soome
Remsu, Olev, 1947-
ETVs näidatud dokumentaalfilmidest sarjas "Eesti lood" - Indrek Kangro film Jaan-Jürgen Klausist "Professionaalne amatöör" (eetris 3. XII 2008), Margit Lillaku film kunstnik Sandra Jõgevast "Ars longa" (eetris 29. X 2008), Eva-Katariina Taimre "Jackpot" lotovõitjatest (eetris 19. XI 2008)
Novembris ja detsembris on ETV ekraanil uued dokumentaalfilmid sarjast "Eesti lood" - "Professionaalne amatöör" (I. Kangro film Jaan-Jürgen Klausist), "Sõjamäng" (M. Arjukese film Ilmar Raagi osalemisest Erna retkel), "Ars longa" (M. Lillaku film kunstnik Sandra Jõgevast)
Hypertension is a leading cause of heart disease and stroke and occurs in nearly one in three U.S. adults. Reducing salt intake can lower blood pressure, helping to prevent and treat hypertension. In this podcast, Dr. Sandra Jackson discusses the importance of consuming a diet low in sodium.
Saat, Mari, 1947-
Pärnu nüüdiskunsti festivalil toimunud performance'i ja seal esinenud Eesti rahvusmeeskoori konfliktist. Näituse "Kehaturg" avamisel toimunud performance'ist "Kadalipp". Kommenteerivad Andrus Kallastu, Al paldrok, Ville-Karel Viirelaiu ja Sandra Jõgeva
Calvert, Sandra L.
Marketing and advertising support the U.S. economy by promoting the sale of goods and services to consumers, both adults and children. Sandra Calvert addresses product marketing to children and shows that although marketers have targeted children for decades, two recent trends have increased their interest in child consumers. First, both the…
... publication of this notice. FOR FURTHER INFORMATION CONTACT: Sandra L. Burrell, Chief, Human Resources Management Division, Defense Contract Audit Agency, 8725 John J. Kingman Road, Suite 2133, Fort Belvoir... following are the names and titles of DCAA career executives appointed to serve as members of the DCAA...
... Date: Upon publication of this notice. FOR FURTHER INFORMATION CONTACT: Sandra L. Burrell, Chief, Human Resources Management Division, Defense Contract Audit Agency, 8725 John J. Kingman Road, Suite 2133, Fort...(c)(4), the following are the names and titles of DCAA career executives appointed to serve as...
Discusses the role of multicultural education in American education, examining Geneva Gay's book on culturally responsive teaching (which argues for culturally responsive teaching, with teaching having the moral courage to help make education more multiculturally responsive) and Sandra Stotsky's book (which argues that multicultural education is a…
These four papers are from a symposium that was facilitated by Laura Bierema at the 1995 conference of the Academy of Human Resource Development (HRD). "The Status of Valuing and Managing Diversity in Fortune 500 Manufacturing and Fortune 500 Service Organizations: Perceptions of Top Human Resource Professionals" (Sandra J. Johnson) reports a…
funds and the farmer-producers in the rural areas are practically begging for start-up funds with which to finance a backyard poultry farm, a cottage...257-70. Burton, Sandra. "Aquino’s Philippines: The Center Holds." Foreign Affairs 65:3 (America and the World 1986): 524-37. Butcher , Scott. U.S
... L BEKKEDAHL, LARRY N BELL, MELODY C BIENIAWSKI, ANDREW J BIERBOWER, WILLIAM J BISHOP, CLARENCE T... BROWN, FRED L BROWN, STEPHANIE H BRUCE, SANDRA D BRYAN, PAUL F BRYAN, WILLIAM N BURROWS, CHARLES W BUTTRESS, LARRY D BUZZARD, CHRISTINE M CADIEUX, GENA E CALBOS, PHILIP T CALLAHAN, SAMUEL N CAMPAGNONE, MARI...
J. Genet. 89, e25Ye29 (http://www.ias.ac.in/jgenet/OnlineResources/90/e25.pdf). In table 1, for locus Aaz1, the core motif should be (ACAT)8 ATAAA(TG)6 and not (ACAT)8. Genetic polymorphism of serotonin transporter 5-HTTLPR: involvement in smoking behaviour. Maria Angelica Ehara Watanabe, Sandra Odebrechet ...
Kultuuritehases Polymer tegutsev Art Container tutvustab Austraalias Brisbane'i festivalil eesti saunakultuuri. Eksponeeritakse arhitektuurilist installatsiooni (kasutatud akendest ehitatud läbipaistev saun) ja esitatakse interaktiivset performance'it "Kümblejad". Töö autorid on Erik Alalooga, Tanel Saar, Sandra Jõgeva, Janno Bergmann, Hans-Gunter Lock
Kunstikonteineri rahvusvaheline kunsti- ja performance'iüritus "Global Container 8" 27. augustil kultuuritehases Polymer. Justin Tyler Tate'i, Auseklis/Usinsi ja Sandra Jõgeva esinemisest. Tom Russotti ja Ernest Truely ürituse kohta valminud dokumentaalist. Simon B. Haefele vestlusringist teemal "Kunsti võim"
Sandra Begay-Campbell, newly elected Chair of the Board of Directors for the American Indian Science and Engineering Society discusses difficulties she has faced, including almost failing college, struggling to find her place in a male-dominated field, and dealing with leadership issues as an American Indian woman. Begay-Campbell stresses the…
Jagodin, Karen, 1982-
Näitused austria kaasaegsest arhitektuurist Eesti Arhitektuurimuuseumis kuni 21. V: "Viin: linnaehitus ja uusim arhitektuur" suures saalis (kuraator Leopold Dungl), kaasneb kataloog; "Elamuehitus Viinis: arhitektuur igaühele" galeriil (näituse idee: Wolfgang Förster, Dietmar Steiner, Alexandra Viehhauser, kuraator A. Viehhauser, kujundus - Span-Arhitektid: Matias del Campo, Sandra Manninger, Sebastian Michalski)
Van Winkle, Katie
The author first learned about cultural diversity and racial justice in Mr. Sanderson's middle school English class. They read a book called "The House on Mango Street" by Sandra Cisneros and learned about a different culture, but also about a community with striking similarities to their own. The main character in the novel, Esperanza,…
This paper attempts to unite "The House on Mango Street" by Sandra Cisneros with the participant and spectator theories of James Britton and D. W. Harding in the hopes that such a union will provide new insights into each. In particular, this article explores how the speech acts of Esperanza, the novel's protagonist, are indicative of a shifting…
Wideochir Inne Tech Malo. Inwazyjne 2013;8:36‑42. 15. Taylor EW, Duffy K, Lee K, Hill R, Noone A, Macintyre I, et al. Surgical site infection after groin hernia repair. Br J Surg. 2004;91:105‑11. 16. Tongaonkar RR, Sandra DL, Kingsnorth AN. Ten year personal experience of using Low Density Polyethylene (LDPE) mesh for.
Relationships Relaxing Resentment Respect Responsibility Rigidity Risks Secrets Self-acceptance Self-esteem Serenity Shame Sharing Silence Slips Slippery ...Bit You (1967) 22041 A Time For Decision (1968) 22138 The Summer We Moved To Elm Street (1972) 22144 The Secret Love of Sandra Blain (1971) 22154
In this article, the author talks about The Trove, a children's space--library doesn't quite cut it--located in the White Plains Public Library, New York. Sandra Miranda, the library's director, came up with the idea for The Trove, although it took the work of many--from her staff to the architects to theatrical designers and fabrications--to…
(Sandra, 1995). Several methods of processing the vegetables are being use without considering the effect on the vitamin C, dietary fiber and minerals components. This study is designed to determine the effect of cooking time on the Vitamin C, dietary fiber. & mineral constituents of T. occidentalis (FP), V. amygdalina (BL),.
6. Pimedate Ööde Festivali filmidest : "Puur" ("La Cage"), režissöör Alain Raoust : Prantsusmaa 2002, "Kuuvalgel" ("Kuutamolla"), režissöör Aku Louhimies : Soome 2001, "Kaunis Martha" ("Bella Martha"), režissöör Sandra Nettelbeck : Saksamaa 2001
XX Willem C. Vis’i nimelise rahvusvahelise kaubandusõiguse harjutuskohtuvõistlusel Viinis saavutas Tartu Ülikooli õigusteaduskonna võistkond (Kristina Promet, Jaana Lints, Edgar-Kaj Velbri ja Sandra-Kristin Noot) 290 ülikooli seast 84. koha
... Hollins Ferry Road, Halethorpe, MD 21227. 020253NF Concord October 22, 2010. International Transport, Inc... Logistics, Inc. October 30, 2010. dba LTH Express, 837 East Sandhill Avenue Carson, CA 90746. 021890F Empire Global October 31, 2010. Logistics, LLC, 160- 51 Rockaway Blvd., Suite 206, Jamaica, NY 11434. Sandra L...
Smeets, Bart; Uhlig, Sandra; Fuss, Astrid; Mooren, Fieke; Wetzels, Jack F M; Floege, Jürgen; Moeller, Marcus J
Cellular lesions form in Bowman's space in both crescentic glomerulonephritis and collapsing glomerulopathy. The pathomechanism and origin of the proliferating cells in these lesions are unknown. In this study, we examined proliferating cells by lineage tracing of either podocytes or parietal epithelial cells (PECs) in the nephrotoxic nephritis model of inflammatory crescentic glomerulonephritis. In addition, we traced the fate of genetically labeled PECs in the Thy-1.1 transgenic mouse model of collapsing glomerulopathy. In both models, cellular bridges composed of PECs were observed between Bowman's capsule and the glomerular tuft. Genetically labeled PECs also populated larger, more advanced cellular lesions. In these lesions, we detected de novo expression of CD44 in activated PECs. In contrast, we rarely identified genetically labeled podocytes within the cellular lesions of crescentic glomerulonephritis. In conclusion, PECs constitute the majority of cells that compose early extracapillary proliferative lesions in both crescentic glomerulonephritis and collapsing glomerulopathy, suggesting similar pathomechanisms in both diseases.
Yagmurca, M; Yasar, Z; Bas, O
The anthracycline antitumor drug doxorubicine causes severe nephrotoxicity in a variety of experimental animals and may be nephrotoxic to humans. The aim of present study was to determine the protective effects of quercetin against doxorubicin-induced kidney injury with light microscopy. Forty male Wistar albino rats were divided into four groups: control, doxorubicin, doxorubicin+quercetin and quercetin. A single dose of 20 mg/kg/ i.p. doxorubicin was used to induce injury. Quercetin was administrated orally against doxorubicin toxicity. The kidneys were examined under light microscopy after H-E (hematoxylin-eosin) staining and the changes were scored. Significant tissue injury was observed in doxorubicin-administered group. Among these injuries, renal tubular dilatation, tubular vacuolar changes, glomerular vacuolization, decrease in bowman space, bowman capsule thickening, and interstitial infiltration were evident. However, the injury induced by doxorubicin was attenuated with quercetin administration. Quercetin decreased doxorubicin-induced kidney damage (Tab. 1, Fig. 4, Ref. 27).
Kiratli, Hayyam; Irkeç, Murat; Alaçal, Sibel; Söylemezoğlu, Figen
To report a highly unusual case of corneal calcification after brief intraoperative use of topical thrombin. A 44-year-old man underwent sclerouvectomy for ciliochoroidal leiomyoma, during which 35 UNIH/mL lyophilized bovine thrombin mixed with 9 mL of diluent containing 1500 mmol/mL calcium chloride was used. From the first postoperative day, corneal and anterior lenticular capsule calcifications developed, and corneal involvement slightly enlarged thereafter. A year later, 2 corneal punch biopsies confirmed calcification mainly in the Bowman layer. Topical treatment with 1.5% ethylenediaminetetraacetic acid significantly restored corneal clarity. Six months later, a standard extracapsular cataract extraction with intraocular lens placement improved visual acuity to 20/60. This case suggests that topical thrombin drops with elevated calcium concentrations may cause acute corneal calcification in Bowman layer and on the anterior lens capsule.
diversity in Northwest Georgia. ijdgontinental Journal of Archaeology 7(l):99-132. -L 5- . . .. . Johnson, L. Lewis 1977 The Aguas Verde industry of...northern Chile . In Advances in Andean Archaeolor, edited by David L. Bowman, pp. 7-39. Mouton, The Hague. Jolley, Robert I. 1978 Archaeological...for Field Archaeology Sociedad de Arqueologia Chilena, Santiago, Chile Recent Publications 1973 - 1979 9 Articles. 1976 - 1978 .2 Books Technical
Human Capital, 13-14. 8 Ibid. 9 Ehrenberg and Smith, Modern Labor Economics , 157. 10 Ibid., 308. 6 The U.S. Army also provides both general and...to Schooling” Journal of Labor Economics Vol. 11, No. 3 (1993): 521- 544. Bowman, William R. and Mehay, Stephen L. “Graduate education and employee...Introduction, New York: M. E. Sharpe, Inc., 1985. Ehrenberg, Ronald G. and Smith, Robert S. Modern Labor Economics : Theory and Public Policy
the bands needed for atmospheric correction. Spectral definition files for AVIRIS, HYDICE, HYMAP, HYPERION, CASI, and AISA sensors are included as...Satellite Visible Imagery – A Review.” In Lecture Notes on Coastal and Estuarine Studies, edited by R. T. Barber, N. K. Mooers, M. J. Bowman, and B...In Proceedings of SPIE Coastal Ocean Remote Sensing, edited by Robert J. Frouin, ZhongPing Lee, Vol. 6680, 668013-1-668013-9. doi:10.1117/12.736845
which account for a majority of all cancer deaths, is limited. The application of immunother- apy to highly proliferative tumors renders the tumors prone...ELISA kit (BD Biosciences, Franklin Lakes, NJ, USA), according to the manufacturer’s protocol . Characterization of splenocytes and tumor...Horton, H. F., Fouser, L., Carter, L., Ling, V., Bowman, M. R., Carreno, B. M., Collins, M., Wood , C. R., Honjo, T. (2000) Engagement of the PD-1
Bowmans Harbour opencast mine is probably unique. Here Clay Colliery is mining an area that was derelict and contaminated land, which became a landfill site. When standards for landfill were raised the Black Country Development Corporation decided to redeposit the waste in a new repository on the same site, using higher standards. New cells for waste are being constructed. In creating these new cells coal is being extracted and sold. Four excavators are involved in this project.
Bill J. Mathews; Eva K. Strand; Alistair M. S. Smith; Andrew T. Hudak; Matthew B. Dickinson; Robert L. Kremens
Fire is a key earth-system and Anthropocene process (Bowman et al. 2009; Smith et al. 2016a). Fire impacts on the global carbon (C) cycle from both anthropogenic and natural sources, with 1350-3400 Tg C emitted from land-use changes, agricultural practices and residential uses, and 2750-4600 Tg C emitted in wildfire events, which exhibit high interannual variability (...
image where a straightened stream channel runs through a residential development. The second WAA occurs in the middle of the image in an...Main Stem Channel Length / Main stem Channel and Tributary Channels Length Calculated Drainage Density Calculated Channel Slope Calculated...thresholds, stormwater detection, and the limits of mitigation. Journal of the American Water Resources Association 35:1077–1090. Bowman, R. H. 1973
Schneider, Remington R S; Eng, Diana G; Kutz, J Nathan; Sweetwyne, Mariya T; Pippin, Jeffrey W; Shankland, Stuart J
Advanced age portends a poorer prognosis in FSGS. To understand the impact of age on glomerular podocytes and parietal epithelial cells (PECs), experimental FSGS was induced in 3m-old mice (20-year old human age) and 27m-old mice (78-year old human age) by abruptly depleting podocytes with a cytopathic anti-podocyte antibody. Despite similar binding of the disease-inducing antibody, podocyte density was lower in aged FSGS mice compared to young FSGS mice. Activated PEC density was higher in aged versus young FSGS mice, as was the percentage of total activated PECs. Additionally, the percentage of glomeruli containing PECs with evidence of phosphorylated ERK and EMT was higher in aged FSGS mice. Extracellular matrix, measured by collagen IV and silver staining, was higher in aged FSGS mice along Bowman's capsule. However, collagen IV accumulation in the glomerular tufts alone and in glomeruli with both tuft and Bowman's capsule accumulation were similar in young FSGS and aged FSGS mice. Thus, the major difference in collagen IV staining in FSGS was along Bowman's capsule in aged mice. The significant differences in podocytes, PECs and extracellular matrix accumulation between young mice and old mice with FSGS might explain the differences in outcomes in FSGS based on age.
Brandon, D L; Bates, A H; Friedman, M
Soybean proteins are widely used in human foods in a variety of forms, including infant formulas, flour, protein concentrates, protein isolates, soy sauces, textured soy fibers, and tofu. The presence of inhibitors of digestive enzymes in soy proteins impairs the nutritional quality and possibly the safety of soybeans and other legumes. Processing, based on the use of heat or fractionation of protein isolates, does not completely inactivate or remove these inhibitors, so that residual amounts of inhibitors are consumed by animals and humans. New monoclonal antibody-based immunoassays can measure low levels of the soybean Kunitz trypsin inhibitor (KTI) and the Bowman-Birk trypsin and chymotrypsin inhibitor (BBI) and the Bowman-Birk foods. The enzyme-linked immunosorbent assay (ELISA) was used to measure the inhibitor content of soy concentrates, isolates, and flours, both heated and unheated; a commercial soy infant formula; KTI and BBI with rearranged disulfide bonds; browning products derived from heat-treatment of KTI with glucose and starch; and KTI exposed to high pH. The results indicate that even low inhibitor isolates contain significant amounts of specific inhibitors. Thus, infants on soy formula consume about 10 mg of KTI plus BBI per day. The immunoassays complement the established enzymatic assays of trypsin and chymotrypsin inhibitors, and have advantages in (a) measuring low levels of inhibitors in processed foods; and (b) differentiating between the Kunitz and Bowman-Birk inhibitors. The significance of our findings for food safety are discussed.
Hwang, D L.R.; Lin, K T.D.; Yang, W K; Foard, D E
Five protease inhibitors, I-V, in the molecular weight range 7000-8000 were purified from Tracy soybeans by ammonium sulfate precipitation, gel filtration on Sephadex G-100 and G-75, and column chromatography on DEAE-cellulose. In common with previously described trypsin inhibitors from legumes, I-V have a high content of half-cystine and lack tryptophan. By contrast with other legume inhibitors, inhibitor II contains 3 methionine residues. Isoelectric points range from 6.2 to 4.2 in order from inhibitor I to V. Molar ratios (inhibitor/enzyme) for 50% trypsin inhibition are I = 4.76, II = 1.32, III = 3.22, IV = 2.17, V = 0.97. Only V inhibits chymotrypsin significantly (molar ratio = 1.33 for 50% inhibition). The sequence of the first 16 N-terminal amino acid residues of inhibitor V is identical to that of the Bowman-Birk inhibitor; all other observations also indicate that inhibitor V and Bowman-Birk are identical. The first 20 N-terminal amino acid residues of inhibitor II show high homology to those of Bowman-Birk inhibitor, differing by 1 deletion and 5 substitutions. Immunological tests show that inhibitors I through IV are fully cross-reactive with each other but are distinct from inhibitor V.
Jamison, Rex L
Marcello Malpighi discovered the glomerulus that bears his name in the 17th century, but it was not until the middle of the 19th century, in 1842, that William Bowman in London published his studies of the histological structure of the glomerulus and proposed that urine formation begins with glomerular secretion. At nearly the same time in Marburg, Carl Ludwig, unaware of Bowman's findings, proposed that urine formation begins with glomerular filtration followed by tubule reabsorption. The controversy lasted 80 yr. Prominent investigators weighed in on both sides. Rudolph Heidenhain's findings in 1874 swung the pendulum toward Bowman's theory until Arthur Cushny published his book, The Secretion of Urine, in 1917, in which he found the evidence insufficient to prove either theory. In 1921, a young physician, Joseph Wearn, began his postresidency training in the laboratory of Alfred N. Richards. He read Cushny's book and learned how to expose the glomerulus of a living frog. Richards proposed that Wearn use that experimental preparation to inject epinephrine into the glomerulus. Wearn proposed a different experiment: instead of using injection, collect fluid from the glomerulus and analyze it. Richards agreed, and the landmark results of that experiment, published in 1924, settled the controversy. The modern era of renal physiology was born. Copyright © 2014 The American Physiological Society.
McLaughlin, D.F.; Lahoda, E.J.; Gass, W.R.; D'Amico, N.
This document provides a test plan for the conduct of plasma arc vitrification testing by a vendor in support of the Hanford Tank Waste Remediation System (TWRS) Low-Level Waste (LLW) Vitrification Program. The vendor providing this test plan and conducting the work detailed within it [one of seven selected for glass melter testing under Purchase Order MMI-SVV-384212] is the Westinghouse Science and Technology Center (WSTC) in Pittsburgh, PA. WSTC authors of the test plan are D. F. McLaughlin, E. J. Lahoda, W. R. Gass, and N. D'Amico. The WSTC Program Manager for this test is D. F. McLaughlin. This test plan is for Phase I activities described in the above Purchase Order. Test conduct includes melting of glass frit with Hanford LLW Double-Shell Slurry Feed waste simulant in a plasma arc fired furnace
Temporal Trends in Clinical and Pathological Characteristics for Men Undergoing Radical Prostatectomy Between 1995 and 2013 at Rigshospitalet, Copenhagen, Denmark, and Stanford University Hospital, United States
Loft, Mathias Dyrberg; Berg, Kasper Drimer; Kjaer, Andreas
Purpose: To analyze how prostate-specific antigen (PSA) screening and practice patterns has affected trends in tumor characteristics in men undergoing radical prostatectomy (RP) in the United States and Denmark. Unlike in the United States, PSA screening has not been recommended in Denmark...... evaluated with Cochran-Armitage test for trends and chi-square testing. Results: A total of 4404 patients were included. Temporal changes in preoperative PSA, age, grade, and stage was found in both cohorts. Median preoperative PSA declined in both cohorts, while median age increased, with the Danish cohort...... showing the greatest changes in both PSA and age. In both cohorts, there was a trend for higher-risk preoperative features before RP over time. In 2010-2013, 27.7% and 21.8% of the patients were in the D'Amico high-risk group at Copenhagen and Stanford, respectively. Conclusion: Despite recommendation...
Røder, Martin Andreas; Brasso, Klaus; Christensen, Ib Jarle
of a shift in attitude with increasing opportunistic PSA testing. This had led to an increasing number of RPs being performed in Denmark. The objective of this study was to analyze changes in preoperative characteristics over time for the complete cohort of 6489 men who underwent RP between 1995 and 2011....... Our hypothesis was that an increasing amount of men undergo RP for lower risk PCa. MATERIAL AND METHODS: All patients operated from 1995 to 2011 were identified via patient files and registries. Changes over time in age at surgery, preoperative PSA, clinical T-category, biopsy Gleason score (GS......, especially after 2005. Biopsy GS = 7 was found in 20.2% of the patients in 2005 compared to 57.1% in 2011. The proportion of T1 disease increased from 32% to 56%. Significant changes in percentage of patients according to the D'Amico classification were found. After 2005 the proportion of intermediate...
Wiig, E H
We are beginning a decade, during which many traditional paradigms in education, special education, and speech-language pathology will undergo change. Among paradigms considered promising for speech-language pathology in the schools are collaborative language intervention and strategy training for language and communication. This presentation introduces management models for developing a collaborative language intervention process, among them the Deming Management Method for Total Quality (TQ) (Deming 1986). Implementation models for language assessment and IEP planning and multicultural issues are also introduced (Damico and Nye 1990; Secord and Wiig in press). While attention to processes involved in developing and implementing collaborative language intervention is paramount, content should not be neglected. To this end, strategy training for language and communication is introduced as a viable paradigm. Macro- and micro-level process models for strategy training are featured and general issues are discussed (Ellis, Deshler, and Schumaker 1989; Swanson 1989; Wiig 1989).
Scorticati, Carlos; Aguilar, Jorge A.; Gonzalez Granda, Pablo; Mendez, Fernando; Montiel, Raul; Rege, Eduardo; Alvarez, Patricio; Lopez, Miguel A.; Rizzi, Alfredo; Mazza, Osvaldo
Introduction and Objectives: To analyze the results of the treatment in patients with cancer of prostate of high risk. Material and Method: Retrospective and observational analysis of 130 patients operated by CAP of high risk (criteria of D'Amico) average 41,48 months, divided in form nonrandomized in three groups 1: radical prostatectomy, 2: neoadjuvant hormonoterapy (BAC) + PR, 3: BAC + PR + x-ray (RT). Statistical analysis: multivaried, test of curved Chi2 and p statistical and of Kaplan Meier. Results: Biochemical relapse 68 patients (52.3%), average 23,37 months. Without differences according to therapeutic modality (p: 0.043). In the multivaried analysis of the 3 factors of presurgical, single risk we found a statistically significant relation in the coexistence of the 3 factors with the presence of positive margin in the PR piece. (p: 0,002). The analysis to make or not, neoadjuvant BAC without significant difference (p: 0,403) evaluating in such the rate of M+, actuarial global survival according to curves of Kaplan Meier to 5 and 10 years (P: 0,5257) and survival 5 actuarial specific cancer to and 10a (P: 0,2165). Conclusions: Without significant differences in: RB, clinical progression, pathological relapse, global and specific survival, rate of positive surgical margins. The 3 criteria of D'Amico were predictive of positive surgical margins and RB, the patients with RB in group 2 presented/displayed greater risk of clinical progression, the PR demonstrated a global survival and specify actuarial to 10 years greater to 50%, considering it therapeutic an option been worth. (authors) [es
Arts@CERN welcomes you to a talk by architects Sandra Manninger and Matias Del Campo, at IdeaSquare (Point 1) on May 19 at 6:00 p.m. Sensible Bodies - architecture, data, and desire. Sandra and Matias are the winning architects for ACCELERATE Austria. Focusing on the notion of geometry, they are at CERN during the month of May, as artists in residence. Their research highlights how to go beyond beautiful data to discover something that could be defined voluptuous data. This coagulation of numbers, algorithms, procedures and programs uses the forces of thriving nature and, passing through the calculation of a multi-core processor, knits them with human desire. Read more. ACCELERATE Austria is supported by The Department of Arts of the Federal Chancellery of Austria. Thursday, May 19 at 6:00 p.m. at IdeaSquare. See event on Indico.
Smeets, Bart; Te Loeke, Nathalie A J M; Dijkman, Henry B P M; Steenbergen, Mark L M; Lensen, Joost F M; Begieneman, Mark P V; van Kuppevelt, Toin H; Wetzels, Jack F M; Steenbergen, Eric J
Focal segmental glomerulosclerosis (FSGS) is a hallmark of progressive renal disease. Podocyte injury and loss have been proposed as the critical events that lead to FSGS. In the present study, the authors have examined the development of FSGS in Thy-1.1 transgenic (tg) mice, with emphasis on the podocyte and parietal epithelial cell (PEC). Thy-1.1 tg mice express the Thy-1.1 antigen on podocytes. Injection of anti-Thy-1.1 mAb induces an acute albuminuria and development of FSGS lesions that resemble human collapsing FSGS. The authors studied FSGS lesions at days 1, 3, 6, 7, 10, 14, and 21, in relation to changes in the expression of specific markers for normal podocytes (WT-1, synaptopodin, ASD33, and the Thy-1.1 antigen), for mouse PEC (CD10), for activated podocytes (desmin), for macrophages (CD68), and for proliferation (Ki-67). The composition of the extracellular matrix (ECM) that forms tuft adhesions or scars was studied using mAb against collagen IV alpha2 and alpha4 chains and antibodies directed against different heparan sulfate species. The first change observed was severe PEC injury at day 1, which increased in time, and resulted in denuded segments of Bowman's capsule at days 6 and 7. Podocytes showed foot process effacement and microvillous transformation. There was no evidence of podocyte loss or denudation of the GBM. Podocytes became hypertrophic at day 3, with decreased expression of ASD33 and synaptopodin and normal expression of WT-1 and Thy-1.1. Podocyte bridges were formed by attachment of hypertrophic podocytes to PEC and podocyte apposition against denuded segments of Bowman's capsule. At day 6, there was a marked proliferation of epithelial cells in Bowman's space. These proliferating cells were negative for desmin and all podocyte markers, but stained for CD10, and thus appeared to be PEC. The staining properties of the early adhesions were identical to that of Bowman's capsule, suggesting that the ECM in the adhesions was produced by PEC
This project focused on identifying selective binding agents for the removal of negative ions that hamper vitrification efforts. The project was led by Professor Kristin Bowman-James at the University of Kansas (KU) and consisted of a collaborative effort between the KU group, the group of Professor Jonathan Sessler at the University of Texas Austin (UT), and Dr. Bruce Moyer at Oak Ridge National Laboratory (ORNL). Research efforts during this funding period have focused on a particularly difficult target species, sulfate ion, which is highly insoluble in borosilicate glass. The project is unique in that it combines the synthetic expertise of the Bowman-James and Sessler groups with the analytical/extraction expertise of the Moyer group at ORNL, with a synergy that can bridge disciplines. Sulfate ion is a relatively small ionic species that, because of its solubility characteristics as well as its caustic nature, are a hindrance to the vitrification process. Not only is it relatively insoluble in the medium that has been chosen to store the wastes, but it also has the potential for accelerating the corrosion of the furnaces used to vitrify the borosilicate in a liquid to allow for waste incorporation. The goal of the Bowman-James group has been to design sequestering agents for sulfate that are selective for that ion over nitrate, for example, to allow for a liquid-liquid extraction step that can remove most of the sulfate prior to vitrification. The collaborative design efforts between the Bowman-James and Sessler groups helped to accelerate progress in the design process. In particular the Bowman-James group has been probing the influence of dimensionality and charge on sulfate binding, i.e., progressing from circular to spherical extractants, while at the same time adding positive charges to the agents so that when sulfate is bound, the resulting species is neutral. Not only does this project serve to benefit the remediation process, but it also provides an
Full Text Available ... condition. We are grateful to have been ranked #1 on U.S. News & World Report's list of the best children's hospitals in the nation for the fourth ... families who inspire us to do our very best for them. Thanks to you, Boston Children's is a place where we can write the greatest children's stories ever told. Sandra L. Fenwick, ... Boston Children's Hospital #1 Ranked Children's Hospital by U. S. News & World Report ...
Full Text Available This is an essay about power and faces. Specifically, it about the faces that manifest in the global self-imaging practice referred to as “selfie culture.” More specifically still, it is about circulation of selfies featuring the face of Sandra Bland, an African American activist with the group Black Lives Matter, who police claim hung herself in a cell after being imprisoned after a routine traffic stop.
Burke SD; Sherr D; Lipman RD
Sandra D Burke,1,2 Dawn Sherr,3 Ruth D Lipman3 1American Association of Diabetes Educators, Chicago, IL, USA; 2University of Illinois at Chicago College of Nursing, Urbana, IL, USA; 3Science and Practice, American Association of Diabetes Educators, Chicago, IL, USA Abstract: Diabetes is a chronic, progressive disease that affects millions worldwide. The paradigm of diabetes management has shifted to focus on empowering the person with diabetes to manage the disease successfully and to improv...
Feminist Groupworkis a very thought-provoking book, although the thoughts and speculations stimulated aren't necessarily those intended. I wish that Sandra Butler and Claire Wintram had sorted out their research results with their tabula rasa in tact. When describing the effects on the female psyche of oppression, imbalance of power and exploitation, they accept continually that these stresses are confined to females.
van Tongeren, Sandra P.
Bij lange, bemande ruimtemissies, bijvoorbeeld naar Mars, kan gevaar schuilen in de kleinste hoekjes. Dat blijkt uit het promotieonderzoek van Sandra van Tongeren. Zij stelt onder meer vast dat al bij kortdurende ruimtemissies opmerkelijke veranderingen optreden in de hoeveelheden en soorten micro-organismen in en op het lichaam van de ruimtevaarder. Van Tongeren analyseerde monsters die werden genomen tijdens korte ruimtemissies naar de Russische Zvezda-module van het ISS, van 2004 tot 2007....
Hodroj,Mohammad Hassan; Jardaly,Achraf; abi Raad,Sarah; Zouein,Annalise; Rizk,Sandra
Mohammad Hassan Hodroj, Achraf Jardaly, Sarah Abi Raad, Annalise Zouein, Sandra Rizk Department of Natural Sciences, Lebanese American University, Beirut, Lebanon Background: Topotecan (TP) is an anticancer drug acting as topoisomerase I inhibitor that is used in the treatment of many types of cancers including leukemia, but it has significant side effects. Andrographolide, a compound extracted from Andrographis paniculata, was recently proven to inhibit the growth of cancer cells and can ind...
Broderick M. Steven Oberste Deborah Moore Sandra Romero-Steiner Christian J. Hansen Dennis J. Faix Report No. 13-53 The views expressed in...firstname.lastname@example.org (M.P. Broderick ). 1 Current address: Office of Public Health Preparedness and Response, CDC, tlanta, GA 30333, USA. ttp...titers examined were those of polio, not of other vaccines givenM.P. Broderick et al. / V utcomes were associated with receipt of the same vaccinations
56. Berliini filmifestivali auhinnasaajatest- Kuldkaru saaja bosnialanna Jasmila Zhbavic filmi "Grbavica" eest, režii Hõbekaru saajad britid Michael Winterbottom ja Mat Whitecross filmi eest "Teekond Guatanamosse" ("The Road to Guantanamo"), parima filmi Hõbekaru ja debüüdiauhinna saanud taanlanna Pernille Fischer Christensen filmi "Seep" eest ja iraanlane Jafar Panahi filmi "Suluseis" eest. Parimad näitlejad olid Sandra Hüller ja Moritz Bleibtreu. Lisatud nimekiri "Võitjad"
56. Berliini filmifestivali auhinnasaajatest- Kuldkaru saaja bosnialanna Jasmila Zhbavic filmi "Grbavica" eest, režii Hõbekaru saajad britid Michael Winterbottom ja Mat Whitecross filmi eest "Teekond Guatanamosse" ("The Road to Guantanamo"), parima filmi Hõbekaru ja debüüdiauhinna saanud taanlanna Pernille Fischer Christensen filmi "Seep" eest ja iraanlane Jafar Panahi filmi "Suluseis" eest. Parimad näitlejad olid Sandra Hüller ja Moritz Bleibtreu
56. Berliini filmifestivali auhinnasaajatest- Kuldkaru saaja bosnialanna Jasmila Zhbavic filmi "Grbavica" eest, režii Hõbekaru saajad britid Michael Winterbottom ja Mat Whitecross filmi eest "Teekond Guatanamosse" ("The Road to Guantanamo"), parima filmi Hõbekaru ja debüüdiauhinna saanud taanlanna Pernille Fischer Christensen filmi "Seep" eest ja iraanlane Jafar Panahi filmi "Suluseis" eest. Parimad näitlejad olid Sandra Hüller ja Moritz Bleibtreu.
Molly Bathje MS, OTR/L
Full Text Available Professor Sandra Edwards, MA, OTR/L, FOATA, and professor emerita at Western Michigan University (WMU, provided the cover art for the winter 2014 issue of The Open Journal of Occupational Therapy. The oil painting, “Silent Witness, Cross Creek” was created over a period of two years. Professor Edwards has participated in many creative and artistic activities throughout her life, which have shaped her practice as an occupational therapist and her experience in life.
behavior of Aedes aegypti Emadeldin Y. Fawaz1, Sandra A. Allan2, Ulrich R. Bernier2, Peter J. Obenauer3, and Joseph W. Diclaro II1 1Vector Biology... Aedes aegypti swarming behavior and identified associated chemical cues. Novel evidence is provided that Ae. aegypti females aggregate by means of...the isolated aggregation pheromones in controlling Ae. aegypti. Journal of Vector Ecology 39 (2): 347-354. 2014. Keyword Index: Aedes aegypti, swarm
Unclassified 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Hart, Sandra G ; Drury , Colin G ; Hancock, Peter A ; Szalma, James...interventions, thereby improving threat inspection and, ultimately, homeland security. n For more information please contact: Colin G. Drury , Ph.D. University...at Buffalo, SUNY Department of Industrial Engineering 342 Bell Hell Hall Buffalo, NY 14260 A Unified Model of Security Inspection Colin G. Drury
Varblane, Reet, 1952-
Mark Soosaare näitus "Aeg" Tallinna Kunstihoone galeriis kuni 23. IV, Jaan Paavle maalinäitus "1 minut" 3.-15. IV Draakoni galeriis, Sandra Jõgeva ja Kristin Kalamehe "Leave like a Lady" Draakoni galerii keldrisaalis 4.-15. IV, Marianne Männi näitus "Paradiis" Hobusepea galeriis 5.-17. IV. Maailma positiivsemale poolusele osutab 20. IV Tallinna Linnagaleriis avatud Mari ja Kaarel Kurismaa ruumiinstallatsioon "Teine süütus"
Effect, 18. 41 Spencer C. Tucker, David Coffey, Nguyen Cong Luan, Nike Nichols, and Sandra Wittman, eds, Encyclopedia of the Vietnam War Volume One: A...War: The Unexamined Victories and Final Tragedy of America’s Last Years in Vietnam, (Orlando, FL :Harcourt, Inc ., 1999), 72-73. 91 Sorley, A Better...Victories and Final Tragedy of America’s Last Years in Vietnam. Orlando, FL: Harcourt, Inc ., 1999. Stubbs, Richard. Hearts and Minds in
British painter Francis Bacon (1909-1992) was known for the eloquence with which he talked about his art. He was easy to talk to, and was interviewed countless times by numerous critics. However, when studying Bacon's paintings one soon comes across the published interviews with art critic and curator David Sylvester (1924-2001), who interviewed him as many as 18 times between 1962 and 1986. Art historian Sandra Kisters argues that Sylvester's interviews with Bacon are carefully constructed a...
Walker, Karen; Woods,; Iuliano-Burns,Sandra; King,Susannah; Strauss,Boyd
Julie L Woods1, Sandra Iuliano-Burns2, Susannah J King1, Boyd J Strauss1, Karen Z Walker11Nutrition and Dietetics Department, Monash University, Victoria, Australia; 2Endocrine Centre of Excellence, Department of Medicine, Austin Health, University of Melbourne, West Heidelberg, AustraliaPurpose: To determine the prevalence of sarcopenia and investigate relationships among body composition, muscle strength, and physical function in elderly women in low-level aged care.Subjects and methods: Si...
Varblane, Reet, 1952-
Prostitutsiooniteemast kunstis, praeguste prostitutsiooni käsitlevate näituste ("Sex Work. Kunst. Mythos. Realität" Berliinis, Ann-Sofi Sideni projekt "Warte mal! Prostitutsion after the Velvet Revolution" jt.) rollist. Pikemalt näitusest "Kehaturg / Sex market" Tallinna Kunstihoones. Anu Juuraku, Foxy Haze'i, Teemu Mäki, Tatjana Antoshina, Kari Bie Erenurme, Sandra Jõgeva, Shula Kesheti, Deimantas Narkeviciuse ja Pal Hollenderi töödest
Kolm võrdset preemiat: Sang-gon Chung Lõuna-Koreast, Krishs Salmanis Lätist ja Joanne Soroka Shotimaalt. Diplomid: Anonymous Boh ja Eve Kiiler Eestist, Pete Nevin Inglismaalt, Hanna Oinonen Soomest ja venetsueela-soome kunstnik Sandra Vina de Karila. Tallinna linna preemia: John Smith (Marko Mäetamm & Kaido Ole) Eestist. Eesti Kunstimuuseumi preemia: Markus Lampinen Soomest. Eesti Panga preemia: Leonards Laganovskis Lätist
During the spring semester of 2012 did Petra Hollsten independently a thesis on reducing the environmental impact of capsule for coffee, tea and chocolate. The work was performed at Karlstad University, Faculty of Technology and Science under the Bachelor of Science program in innovation, technology and design. The project's scope is at 22.5 points. The employment for this project is the company Löfbergs Lila AB in Karlstad. Supervisor at the Principal has been Maria Herou Wallner and Sandra ...
Besmer*, Teresa L. Tinder , Lopamudra Das Roy, Joseph Lustgarten, Sandra J. Gendler, Pinku Mukherjee Intratumoral Delivery of CpG-Conjugated Anti...3073-87. Epub 2012 Jan 11. PMID: 22238308 3. Mahnaz Sahraei , Lopamudra Das Roy , Jennifer Curry , Teresa Tinder , Sritama Nath , Dahlia M...10.1038/onc.2011.651 4. Dahlia M. Besmer , Dr. Jennifer M. Curry , Dr. Lopamudra D. Roy , Ms. Teresa L. Tinder , Ms. Mahnaz M. Sahraei , Dr
Lewis, Sandra J
Sandra J LewisNorthwest Cardiovascular Institute, Portland, OR, USAAbstract: Cardiovascular disease (CVD) is the leading cause of death in the US. Despite the decline in CVD-associated mortality rates in recent years, coronary heart disease (CHD) still causes one in every six deaths in this country. Because most CHD risk factors are modifiable (eg, smoking, hypertension, obesity, onset of type 2 diabetes, and dyslipidemia), cardiovascular risk can be reduced by timely and appropriate interven...
Müürsepp, Mare, 1958-
Artikkel on kirjutatud Sandra Rannastiku magistritöö põhjal (Tallinna Ülikool, kasvatusteaduste instituut, algõpetuse osakond, 2014). Magistritöö põhineb uuringul, mille jaoks valiti välja kümme raamatut, et uurida milliseid ootusi üks või teine raamat lastes tekitab ja viidi läbi 72 neljanda klassi õpilase hulgas
Gourgari, Evgenia; Spanakis,Elias; Dobs,Adrian
Evgenia Gourgari,1 Elias Spanakis,2 Adrian Sandra Dobs3 1Division of Pediatric Endocrinology, Georgetown University School of Medicine, Washington, DC, 2Division of Endocrinology, University of Maryland School of Medicine, 3Department of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, MD, USA Abstract: Polycystic ovary syndrome (PCOS) is a syndrome associated with insulin resistance (IR), obesity, infertility, and increased cardiometabolic risk. This is a des...
Full Text Available The work of diversity in libraries begins at the crossroad where superiority, inaction, and denial become intolerable. – Sandra Ríos Balderrama, “This Trend Called Diversity” In Brief: Despite our ongoing quest for diversity and a growing number of initiatives to increase it, the demographics of the professional librarian population haven’t changed in any significant way. […
Hypertension is a leading cause of heart disease and stroke and occurs in nearly one in three U.S. adults. Reducing salt intake can lower blood pressure, helping to prevent and treat hypertension. In this podcast, Dr. Sandra Jackson discusses the importance of consuming a diet low in sodium. Created: 1/14/2016 by MMWR. Date Released: 1/14/2016.
Theo & Seth: 1. Precalculus Test quences orally, to order numbers, to decom- (by Neva Milicic and Sandra Schmidt) that pose numbers through audio... Precalculus Test 81 7911 80 6975 -109 1 109 70 •100 91 e60 55 582:t5 30 •46 4 37 20 28 - 10 L _ _19- 10 3 7 - O Pre Test casos 0 Post Test Figure 6-7
Goodson, William H.; Lowe, Leroy; Carpenter, David O.; Gilbertson, Michael; Manaf Ali, Abdul; Lopez de Cerain Salsamendi, Adela; Lasfar, Ahmed; Carnero, Amancio; Azqueta, Amaya; Amedei, Amedeo; Charles, Amelia K.; Collins, Andrew R.; Ward, Andrew; Salzberg, Anna C.; Colacci, Anna Maria
John Pierce Wise Sr. and Sandra S.Wise were supported by National Institute of Environmental Health Sciences (ES016893 to J.P.W.) and the Maine Center for Toxicology and Environmental Health; Jonathan Whitfield acknowledges support from the FERO Foundation in Barcelona, Spain; Joseph Christopher is funded by Cancer Research UK and the International Journal of Experimental Pathology; Julia Kravchenko is supported by a philanthropic donation by Fred and Alice Stanback; Jun Sun is supported by a...
56. Berliini filmifestivali auhinnasaajatest- Kuldkaru saaja bosnialanna Jasmila Zhbavic filmi "Grbavica" eest, režii Hõbekaru saajad britid Michael Winterbottom ja Mat Whitecross filmi eest "Teekond Guatanamosse" ("The Road to Guantanamo"), parima filmi Hõbekaru ja debüüdiauhinna saanud taanlanna Pernille Fischer Christensen filmi "Seep" eest ja iraanlane Jafar Panahi filmi "Suluseis" eest. Parimad näitlejad olid Sandra Hüller ja Moritz Bleibtreu. Eestlased filmiturul. Lisatud nimekiri "56. Berliini rahvusvahelise filmifestivali auhinnad"
Туумалу, Тийт, 1971-
Näitleja Sandra Bullock tänas oma Filminäitlejate Gildi Auhindade (American Screen Actors Guild Awards) tseremoonia tänukõnes ka operaator Alar Kivilod. Artiklis Kanadas sündinud ja Los Angeleses töötavast eesti päritolu filmioperaatorist ning lähemalt tema ühest südamelähedasemast tööst, filmist "Taking Chance" (USA 2009)
23. V toimunud rahvusvahelise tegevuskunstifestivali "Diverse Universe IV" performance''i-programmist Non Grata Kunstikonteineris Kultuuritehases Polymer. Sandra Jõgeva ja rühmituse Cnopt, rühmituse Non Grata, korealase Kim Baek-Ki ning sakslaste Micha Stegeri ja Andreas Stadleri, poolakate Marta Zioleki ja Agata Siniarska, ameeriklase Travis McCoy Fulleri, Russ Butleri (Bermuda), rühmituse HorseCow (Sacramento) performance'itest. Lühidalt Non Grata videonäitusest
mohamad khosravi farsani
Full Text Available Agha Ali and Jelveh ,two of outstanding of Tehran philosophy school, have reconsidered Sandra's opinions in two opposite sides. Agha Ali is the claimant of negation and ambiguity in most of Sandra's opinions while emphasizing on transcendent theosophy foundations ,and he tries to make these ambiguities clear .However , Jelveh follows Avicenna's way and has the idea of criticizing Sandra .This article has chosen the problem Of immortality of subject in substantial movement between all debates of these two philosophers of the same age.in this essay we are going to survey Agha Ali's claims in his new explantation in one hand ,and survey and criticize the new explanation of Jelveh in negation Of substantial movement .One of the consequences of surveying and criticizing these two philosophers is that we recognize Agha Ali has succeeded in making Sadra's opinions clear by presenting a new explanation of substantial movement subject. However ,Jelveh has merged Sadra's opinions with Avicenna's instead of debilitating Sadra's opinions and stabilizing Avicenna's opinions.
Mader, Jessica R; Resch, Zachary T; McLean, Gary R; Mikkelsen, Jakob H; Oxvig, Claus; Marler, Ronald J; Conover, Cheryl A
We investigated pregnancy-associated plasma protein-A (PAPP-A) in diabetic nephropathy. Normal human kidney showed specific staining for PAPP-A in glomeruli, and this staining was markedly increased in diabetic kidney. To assess the possible contribution of PAPP-A in the development of diabetic nephropathy, we induced diabetes with streptozotocin in 14-month-old WT and Papp-A knockout (KO) mice. Renal histopathology was evaluated after 4 months of stable hyperglycemia. Kidneys from diabetic WT mice showed multiple abnormalities including thickening of Bowman's capsule (100% of mice), increased glomerular size (80% of mice), tubule dilation (80% of mice), and mononuclear cell infiltration (90% of mice). Kidneys of age-matched non-diabetic WT mice had similar evidence of tubule dilation and mononuclear cell infiltration to those of diabetic WT mice, indicating that these changes were predominantly age-related. However, thickened Bowman's capsule and increased glomerular size appeared specific for the experimental diabetes. Kidneys from diabetic Papp-A KO mice had significantly reduced or no evidence of changes in Bowman's capsule thickening and glomerular size. There was also a shift to larger mesangial area and increased macrophage staining in diabetic WT mice compared with Papp-A KO mice. In summary, elevated PAPP-A expression in glomeruli is associated with diabetic nephropathy in humans and absence of PAPP-A is associated with resistance to the development of indicators of diabetic nephropathy in mice. These data suggest PAPP-A as a potential therapeutic target for diabetic nephropathy.
Thompson, K P; Hanna, K; Waring, G O; Gipson, I; Liu, Y; Gailitis, R P; Johnson-Wint, B; Green, K
Many of the deficiencies with human tissue epikeratoplasty might be improved by the use of a suitable synthetic lenticule. Potential biomaterials for epikeratoplasty include collagen (types I, III, or IV), collagen-hydrogel copolymers, bioactive synthetics, and coated hydrogels. The biomaterial must be engineered to achieve strict specifications of optical clarity, support of epithelial migration and adhesion, permeability to solutes, and stability to corneal proteases. Attaching synthetic lenticules to the cornea without cutting Bowman's layer by adhesives, laser welding, or direct adhesion may also improve the efficacy of synthetic epikeratoplasty.
, Novozymes. Research indicates that besides accommodating a legal demand for the disclosure of company financial details, the annual report, in particular the letter to the shareholders or the CEO's letter, serves the purpose of marketing the company to its constituents (Bowman 1984; Bülow-Møller 2003...... discourse. In this context, the rhetorical appeals of rationality, credibility and affect play an important role. Further, the New Rhetorical focus on audience, involving the concept of ‘presence', as well Conceptual Metaphor Theory's focus on metaphor's cognitive and functional qualities yields useful...
Fernández J., Leoncio; Facultad de Economía y Planificación, Universidad Nacional Agraria La Molina (Perú).
Esta investigación tuvo como objetivo definir la estrategias para la competitividad en la agroexportación de alcachofa, aplicando para ello el modelo de Michael porter referida a las estrategias genéricas o generales; pero complementando el análisis con el modelo de Cliff Bowman, que sitúa mas apropiadamente en el entorno la definición de la estrategia. El resultado fue definir el “liderazgo en costos” como estrategia para la competitividad, complementado con una estrategia de diferenciación....
Conrad, G. W.; Luer, C. A.; Paulsen, A. Q.; Funderburgh, J. L.; Spooner, B. S. (Principal Investigator)
Morphogenesis of the clearnose skate, Raja eglanteria, was not significantly inhibited as a result of 7 days of exposure to 1-2 mM selenate in the sea water during Days 59-69 of embryonic development (hatching would normally have occurred at 82 +/- 4 days of incubation). Although corneal transparency appeared normal in the eye, preliminary measurements of the thickness of Bowman's layer of the cornea suggested that it was significantly thinner in the corneas of embryos exposed to 1-2 mM selenate. Selenate is an ion reported to inhibit sulfation of glycosaminoglycans in connective tissue.
the sample was determined in an Aminco- Bowman Spectrophotofluorometer (American Instrument Co., Silver Spring, MD) at an emission wavelength of 420...S2 0 3 10.0 0.35 ± 0.13 0.44 ± 0.06 0.64 ± 0.38 0.74 ± 0.± 0 NaNOr + 5.0 0.42 ± ,. 0.e5 ± 0.30 0.74 ± 0.39 0.79 = 0.33 Na-S0, .0 a Rat
Abdel-Baki, Abdel-Azeem S; Abdel-Haleem, Heba M; Sakran, Thabet; Zayed, Eman; Ibrahim, Khalid E; Al-Quraishy, Saleh
Two Myxobolus spp. are described from the kidney of the Nile tilapia (Oreochromis niloticus) collected from the River Nile, Egypt. The prevalence of infection was 61 % (47/77), with the infected fish in each case parasitized by the two Myxobolus species simultaneously. The infection was exhibited as free spores in Bowman capsules and renal glomeruli, which makes their original structures difficult to discern. In some cases, the infection appeared as a fibrous plasmodia-like structure containing degenerated developmental stages and spores in the interstitium. The paper identifies each species based on the morphological characteristics of its spores and identifies the histological impacts of Myxobolus infection in this species of fish.
Pokorny, L.; Kelemen, J.
Forty-seven dogs or seventy-four kidneys, respectively, were used in studies into the activity of metrizamide (Amipaque). The angiograms were of good quality; as compared with contrast media tested before, the incidence of abnormalities was somewhat lower, and the symptoms (spasm, inhomogeneous nephrogram) were less important. Histological examination showed that plenty of homogeneous pink proteinlike substance had accumulated in many tubules as well as in the lumen of the Bowman's capsules; fibroses were seen in several parts after 7 and 28 days, respectively. However, the evaluation of the renal function showed no considerable changes in the laboratory values. (orig.) [de
Fedorenko, B.S.; Kabachenko, A.N.; Smirnova, O.A.
A study was made of the effect of adeturon or complex treatment on the development of structural derangements, the volume of renal glomeruli and Bowman's capsules in kidneys of monkeys exposed to 240 MeV protons in a dosage of 700 rad. Injection or adeturon (100 mg/kg) 15 min before irradiation, or treatment with antibiotics and vitamins fail to lower the degree of morphological damage to kidneys. It is assumed that processes of autosensitization in the irradiated animal organism play an important role in the development of radiation injury to kidneys
Taheri, Diana; Chehrei, Ali; Samanianpour, Pargol; Hassanzadeh, Amar; Sadrarhami, Shohreh; Seyrafian, Shiva
To evaluate the correlation of clinical, laboratory, and pathological features at pre-sentation of focal segmental sclerosis (FSGS), we reviewed in a cross sectional study the pathological findings of kidney biopsies in 64 cases of primary FSGS, and correlated them with the clinical and laboratory data obtained at the time of the biopsies. The data included blood pressure, glomerular filtration rate (GFR), serum albumin, and the level of proteinuria. The mean level of serum creatinine was significantly higher in the biopsies' findings of synechiae (adhesions) in the Bowman's capsule, interstitial fibrosis, and global scars (PBowman's capsule in their biopsies.
Pérez, Haydée J.; Carboni, Sandra
Se propone incluir el riesgo contable como una nueva categoría dentro del riesgo asistemático, conceptualizando dicho riesgo y analizando los factores que lo determinan, para incluir su estimación como una etapa dentro de la metodología del análisis económico-financiero basado en información contable. Fil: Pérez, Haydée J. Universidad Nacional de Mar del Plata. Facultad de Ciencias Económicas y Sociales; Argentina. Fil: Carboni, Sandra. Universidad Nacional de Mar del Plata. Facultad de...
Baltazar, Daniele Ferreira Barbosa dos Santos
Orientadora : Profª. Drª. Sandra M. W. Barreira Co-orientadora : Profª. Drª. Grace M. F. C. Wile Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências da Saúde, Programa de Pós-Graduação em Ciências Farmacêuticas. Defesa: Curitiba, 27/03/2015 Inclui referências Área de concentração: Insumos, medicamentos e correlatos Resumo: A obesidade infantil se caracteriza como uma epidemia, sendo um dos principais desafios da saúde pública no momento. Seu combate pode ...
Na sequência do escândalo que explodiu nos EUA em Outubro de 2017 envolvendo o produtor americano de cinema Harvey Weinstein, nasceram os hashtags #Balancetonporc e #MeToo que levaram dezenas de milhares de mulheres a testemunhar sobre as violências sexuais. No Twitter, #Balancetonporc foi lançado no dia 13 de Outubro por uma jornalista francesa, Sandra Muller, e dois dias depois a atriz americana, Alyssa Milano, tomou uma iniciativa semelhante com #MeToo. O efeito bola de neve das redes soci...
WILLIAM DEICH,1 BRIAN DUPRAW,1 WAYNE EARTHMAN,1 HARLAND EPPS,1 SANDRA FABER,1 DEBRA FISCHER ,3 ELINOR GATES,1 DAVID HILYARD,1 BRAD HOLDEN,1 KEN JOHNSTON,4...SANDY KEISER,2 DICK KANTO,1 MYRA KATSUKI,1 LEE LAITERMAN,1 KYLE LANCLOS,1 GREG LAUGHLIN,1 JEFF LEWIS,1 CHRIS LOCKWOOD,1,5 PAUL LYNAM,1 GEOFFREY MARCY,6...with S. Vogt as principal investigator, G. Marcy and D. Fischer as coinvestgators, and M. Radovan as project manager and principal engineer. A large
EKLi volikogu töökoosolek 5. IV. SA ERF alllfondina loodud Olev Soansi mälestusfondi toetamisest, EKLi 2005. a. aastanäituse korraldamisest Tallinna Kunstihoones, vajalikest täiendustest ja muudatustest põhikirjas, mis puudutavad tehinguid Tallinna Kunstihoone ja selle galeriiga. Võeti vastu tööjuhised SA Tallinna Kunstihoone Fondi nõukogule. EKLi uued liikmed: Kaarel Eelma, Piret Hirv, Sandra Jõgeva, Irene Jürna, Kristin Kalamees, Kristiina Laurits, Eve Margus-Villems, Villu Plink, Lembe Ruben, Katrin Sipelgas, Margus Tamm, Tanel Veenre
evaluated after each mission using the NASA - TLX method . Moreover, they were interviewed to be able to state problems and suggest system...France, 3 rd -4 th September 2008.  Sandra G. Hart & Lowell E. Staveland (1988). Development of NASA - TLX (Task Load Index): Results of...o b s e rv a b le b e h a v io u r o f C P = A C U b e h a v io u r Interpretation Figure 11: The Cognitive Process for generating knowledge
Noorte maalikunstnike ühisnäitused "Shoot or Shout - No Escape" Vilniuse Art's Printing House'is 19. X-3. XI 2006 (lisaks kodus maalitud töödele maalisid Aivar Reisner, Sirli Hein ja Rait Rosin remake'e leedu kunstnike töödest) ja "Fresh Paint" Vaal-galeriis 29. III-17. IV. Paaride Triinu Lill ja Agne Jonkute, Sirli Hein ja Sandra Lukoshevichiute, Agne Kulbyte ja Merike Estna ning Rait Rosina, Konstantinas Gaitanzhi ja Elis Saarevälja töödest
Neither fear of heights nor the cold succeeded in cooling the ardour of four brave climbers from CERN who celebrated CERN's 50th Anniversary at the summit of Mount Kilimanjaro (5,895 metres). On the way back from the summit, Miguel Cerqueira Bastos (AB/PO), David Collados Polidura (IT/GM), Sandra Sequeira Tavares (PH/CMI) and Daniel Cano Ott (n_TOF) raised the official CERN Jubilee flag at 4750 metres altitude. How long will it be before a CERN flag is planted on the moon?
Maria Célia Orlato Selem
Resumo: A presente pesquisa busca identificar poéticas feministas no cinema de mulheres latino-americanas neste século XXI. Nesse intuito, foram selecionados os seguintes filmes: La teta asustada, de Claudia Llosa (Peru - 2009); Que tan lejos, de Tania Hermida (Equador - 2006); Rompecabezas, Natalia Smirnoff (Argentina, 2009); Entre nós, de Paola Mendoza e Gloria La Morte (Colômbia, 2009); Sonhos Roubados, de Sandra Werneck (Brasil, 2009); En la puta vida, de Beatriz Flores Silva (Uruguai, 20...
Carbonell-Barrachina, Ãngel; Munera-Picazo,Sandra; Cano-Lamadrid,Marina; BurlÃ³,Francisco; CastaÃ±o-Iglesias,MarÃa ConcepciÃ³n
Sandra Munera-Picazo,1 Marina Cano-Lamadrid,1 María Concepción Castaño-Iglesias,2 Francisco Burló,1 Ángel A Carbonell-Barrachina11Food Quality and Safety Group, Department of Agro-Food Technology, Universidad Miguel Hernández, Orihuela, 2Servicio de Pediatría, Hospital Universitario San Juan de Alicante, Alicante, SpainAbstract: Rice is a staple food for over half of the world population, but there is some concern ab...
Girell, Cecilia; Kjellström, Sandra
Abstract Title: PR consultants and bloggers; a win-win situation? - A study of PR consultants’ new adaptations in the labour market due to the emergence of fashion bloggers. Authors: Cecilia Girell, Sandra Kjellström Tutor: Ylva Ekström Purpose: With the expansion of the Internet, fashion bloggers have gotten more power. A few companies have understood this powerful and reasonable cheap marketing channel. Despite this, most companies still feel powerless, but what has happened to the wor...
through the National Security Doctrine, the ALCA (Area de Libre Comercio de las Americas, The Free Trade Area of the Americas) is, the Plan Colombia...of books such as El Mossad and Las Armas Secretas de la Cía). Other sources like El Universal of Mexico (30-OCT- 03), have stated that Al Qaeda has...María Edith Bordón”, Sandra Quiñónez, prosecutor of the Counter Kidnapping Unit said in El Tiempo newspaper. Bordón was kidnapped on September 21
Ascenso, Andreia; Raposo, Sara; Batista, Cátia; Cardoso, Pedro; Mendes, Tiago; Praça, Fabíola Garcia; Bentley, Maria Vitória Lopes Badra; Simões, Sandra
Andreia Ascenso,1 Sara Raposo,1 Cátia Batista,2 Pedro Cardoso,2 Tiago Mendes,2 Fabíola Garcia Praça,3 Maria Vitória Lopes Badra Bentley,3 Sandra Simões1 1Instituto de Investigação do Medicamento (iMed.ULisboa), 2Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal; 3Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Monte ...
Fábio Vergara Cerqueira
Full Text Available O quarto número dos Cadernos procura trazer estudos concernentes às três temáticas centrais da publicação, Patrimônio, Antropologia e Arqueologia. Composto por seis artigos e uma resenha, a composição autoral deste volume mescla, intencionalmente, autores consagrados em suas áreas de pesquisa, como os historiadores Sandra Pesavento e Francisco Marshall, com jovens pesquisadores, formados na própria UFPEL, como Rafael Guedes Milheira, Welcsoner Silva da Cunha e Luiz Carlos da Silva Júnior.
Hoffman, Anna; Ahlinder, Sandra
Abstract Title: If it doesn’t spread it’s dead - a qualitative study on how young entrepreneurs are positioning themselves in the marketplace and with the help of social media spreading their brand. (If it doesn’t spread it’s dead - en kvalitativ studie om hur unga entreprenörer positionerar sig på marknaden, med hjälp av sociala medier sprider sitt varumärke). Number of pages: 48 Author: Sandra Ahlinder, Anna Hoffman Tutor: Peder Hård af Segerstad Course: Media and Communications Stud...
Maria Luiza V. Oliva
Full Text Available Obtained from leguminous seeds, various plant proteins inhibit animal proteinases, including human, and can be considered for the development of compounds with biological activity. Inhibitors from the Bowman-Birk and plant Kunitz-type family have been characterized by proteinase specificity, primary structure and reactive site. Our group mostly studies the genus Bauhinia, mainly the species bauhinioides, rufa, ungulata and variegata. In some species, more than one inhibitor was characterized, exhibiting different properties. Although proteins from this group share high structural similarity, they present differences in proteinase inhibition, explored in studies using diverse biological models.Obtidas de sementes leguminosas, várias proteínas inibem proteinases de origem animal, incluindo humanas, e podem ser consideradas para o desenvolvimento de compostos com atividade biológica. Inibidores da família Bowman-Birk e da família Kunitz vegetal tem sido caracterizados em relação a especificidade para proteinase, estrutura primária e sitio reativo. O nosso grupo majoritariamente vem estudando o gênero Bauhinia, principalmente as espécies bauhinioides, rufa, ungulatae variegata. Em algumas espécies, mais de um inibidor com propriedades diferentes foi caracterizado. Embora tais proteínas apresentem alta similaridade estrutural, diferem quanto à inibição de proteinases, e foram exploradas em estudos utilizando diversos modelos biológicos.
Hamano, Yuki; Okude, Takashi; Shirai, Ryota; Sato, Ikumi; Kimura, Ryota; Ogawa, Makoto; Ueda, Yoshihiko; Yokosuka, Osamu; Kalluri, Raghu; Ueda, Shiro
Collagen XVIII is a component of the highly specialized extracellular matrix associated with basement membranes of epithelia and endothelia. In the normal kidney, collagen XVIII is distributed throughout glomerular and tubular basement membranes, mesangial matrix, and Bowman's capsule. Proteolytic cleavage within its C-terminal domain releases the fragment endostatin, which has antiangiogenic properties. Because damage to the glomerular basement membrane (GBM) accompanies immune-mediated renal injury, we investigated the role of collagen XVIII/endostatin in this disorder. We induced anti-GBM glomerulonephritis in collagen XVIII alpha1-null and wild-type mice and compared the resulting matrix accumulation, inflammation, and capillary rarefaction. Anti-GBM disease upregulated collagen XVIII/endostatin expression within the GBM and Bowman's capsule of wild-type mice. Collagen XVIII/endostatin-deficient mice developed more severe glomerular and tubulointerstitial injury than wild-type mice. Collagen XVIII/endostatin deficiency altered matrix remodeling, enhanced the inflammatory response, and promoted capillary rarefaction and vascular endothelial cell damage, but did not affect endothelial proliferation. Supplementing collagen XVIII-deficient mice with exogenous endostatin did not affect the progression of anti-GBM disease. Taken together, these results suggest that collagen XVIII/endostatin preserves the integrity of the extracellular matrix and capillaries in the kidney, protecting against progressive glomerulonephritis.
Koulouridis, Efstathios; Koulouridis, Ioannis
The first description of the renal tubules is attributed to Lorenzo Bellini in 1662 and four years later Marcello Malpighi described the glomerulus. In 1842 Sir William Bowman described the capsule that surrounds the Malpighian body and its connection with the renal tubule and introduced the "excretory" hypothesis of urine formation. In the same year, Carl Ludwig introduced the "filtration-reabsorption" hypothesis of urine formation. Bowman's hypothesis was accepted by the so-called "vitalists" and Ludwig's hypothesis by the so-called "mechanists". In the middle of this confliction, Jacob Henle described in 1862 the homonymous "U" shaped loop but his discovery has neglected. In 1942 Werner Kuhn, a physical chemist, proposed that the loop of Henle may be the natural analog of the hairpin countercurrent multiplication system which concentrates urine in mammalian kidneys. In 1951 Kuhn, Hargitay and Wirz showed experimentally that the loop of Henle was the most important part of the countercurrent multiplication system of urine-concentrating mechanism in mammalian kidneys. The new theory was accepted by English-speaking scientists later, in 1958, when Carl Gottschalk and Margaret Mylle published their experimental work and proved that Kuhn's theory was correct. Gottschalk summarized the evidence of the accumulated knowledge in 1962, three centuries after the first description of renal tubules and one century after description of Henle's loop.
Parietal epithelial cells of Bowman's capsules were first described by Sir William Bowman in 1842 in his paper On the Structure and Use of the Malpighian Bodies of the Kidney [London, Taylor, 1842], but since then their functions have remained poorly understood. A large body of evidence has recently suggested that parietal epithelial cells represent a reservoir of renal progenitors in adult human kidney which generate novel podocytes during childhood and adolescence, and can regenerate injured podocytes. The discovery that parietal epithelial cells represent a potential source for podocyte regeneration suggests that podocyte injury can be repaired. However, recent results also suggest that an abnormal proliferative response of renal progenitors to podocyte injury can generate hyperplastic glomerular lesions that are observed in crescentic glomerulonephritis and other types of glomerular disorders. Taken together, these results establish an entirely novel view that changes the way of thinking about renal physiology and pathophysiology, and suggest that understanding how self-renewal and fate decision of parietal epithelial cells in response to podocyte injury may be perturbed or modulated will be crucial for obtaining novel tools for prevention and treatment of glomerulosclerosis. Copyright © 2011 S. Karger AG, Basel.
Taheri, Diana; Chehrei Ali; Samanianpour, Pargol; Hassanzadeh, Amar; Sadrarhami, Shohreh; Shiva, Seyrafian
To evaluate the correlation of clinical, laboratory, and pathological features at presentation of focal segmental sclerosis (FSGS), we reviewed in a cross sectional study the pathological findings of kidney biopsies in 64 cases of primary FSGS, and correlated them with the clinical and laboratory data obtained at the time of the biopsies. The data included blood pressure, glomerular filtration rate (GFR), serum albumin, and the level of proteinuria. The mean level of serum creatinine was significantly higher in the biopsies' findings of synechiae (adhesions) in the Bowman's capsule, interstitial fibrosis, and global scars (P< 0.05), and mean level of GFR was significantly lower with the presence of interstitial fibrosis (P< 0.05). Furthermore, there was a positive correlation between the level of serum creatinine and global sclerosis (r= 2.21, P= 0.04), and a negative correlation between the level of GFR and global sclerosis(r= 2.01, P= 0.02). All the patients with renal insufficiency had interstitial fibrosis in their biopsies in comparison of only the 24 patients (48%) of the group without renal insufficiency (P< 0.05). There was no significant difference between patients with and without hypertension and nephritic-ranged proteinuria. We conclude that we found a correlation of renal insufficiency in primary FSGS patients with interstitial fibrosis, global scars and the synechiae of Bowman's capsule in their biopsies. (author)
Andeen, Nicole K; Nguyen, Tri Q; Steegh, Floor; Hudkins, Kelly L; Najafian, Behzad; Alpers, Charles E
Reversal of diabetic nephropathy (DN) has been achieved in humans and mice, but only rarely and under special circumstances. As progression of DN is related to podocyte loss, reversal of DN requires restoration of podocytes. Here, we identified and quantified potential glomerular progenitor cells that could be a source for restored podocytes. DN was identified in 31 human renal biopsy cases and separated into morphologically early or advanced lesions. Markers of podocytes (WT-1, p57), parietal epithelial cells (PECs) (claudin-1), and cell proliferation (Ki-67) were identified by immunohistochemistry. Podocyte density was progressively reduced with DN. Cells marking as podocytes (p57) were present infrequently on Bowman's capsule in controls, but significantly increased in histologically early DN. Ki-67-expressing cells were identified on the glomerular tuft and Bowman's capsule in DN, but rarely in controls. Cells marking as PECs were present on the glomerular tuft, particularly in morphologically advanced DN. These findings show evidence of phenotypic plasticity in podocyte and PEC populations and are consistent with studies in the BTBR ob/ob murine model in which reversibility of DN occurs with podocytes potentially regenerating from PEC precursors. Thus, our findings support, but do not prove, that podocytes may regenerate from PEC progenitors in human DN. If so, progression of DN may represent a modifiable net balance between podocyte loss and regeneration.
Gagliardini, Elena; Benigni, Ariela
The incidence of kidney diseases is increasing worldwide and they are emerging as a major public health problem. Once mostly considered inexorable, renal disease progression can now be halted and lesions can even regress with drugs such as angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II type I receptor blockers, indicating the possibility of kidney repair. The discovery of renal progenitor cells lining the Bowman capsule of adult rat and human kidneys has shed light on the mechanism of repair by ACEi. Parietal progenitors are a reservoir of cells that contribute to podocyte turnover in physiological conditions. In the early phases of renal disease these progenitors migrate chaotically and subsequently proliferate, accumulating in Bowman's space. The abnormal behavior of parietal progenitors is sustained by the activation of CXCR4 receptors in response to an increased production of the chemokine SDF-1 by podocytes activated by the inflammatory environment. Ang II, via the AT1 receptor, also contributes to progenitor cell proliferation. The CXCR4/SDF-1 and Ang II/AT1 receptor pathogenic pathways both pave the way for lesion formation and subsequent sclerosis. ACEi normalize the CXCR4 and AT1 receptor expression on progenitors, limiting their proliferation, concomitant with the regression of hyperplastic lesions in animals, and in a patient with crescentic glomerulopathy. Understanding the molecular and cellular determinants of regeneration triggered by renoprotective drugs will reveal novel pathways that might be challenged or targeted by pharmacological therapy. © 2014 S. Karger AG, Basel.
Koponen, Kari; Ritola, Ossi; Huuskonen, Sirpa E.; Lindstroem-Seppae, Pirjo [Univ. of Kuopio (Finland). Dept. of Physiology; Myers, Mark S. [National Oceanic and Atmospheric Administration, Seattle, WA (United States). National Marine Fisheries Service
The purpose of this study was to evaluate the potential toxic effects of chronic sublethal polychlorinated biphenyl (PCB) exposure on feral fish, using histopathology as an endpoint. Histopathological study of bream (Abramis brama) and asp (Aspius aspius) living in a PCB-polluted freshwater lake revealed abnormal cellular changes in the renal corpuscle of both species. Dilation of glomerular capillaries (DGC), mesangial edema (ME), an adhesion between visceral and parietal layers of Bowman's capsule (ABC), and filling of Bowman's space (FBS), were highly prevalent features in lake fish. The prevalence of each of these lesions was significantly lower, or totally absent in fish caught from reference locations. Cellular alterations in liver, gill, gonads, spleen, and intestine were all linked to seasonal changes. The results suggest that some of the observed histopathological changes in renal glomeruli, particularly DGC and ME, could possibly indicate a prolonged chemical stress caused by PCBs and related compounds. It is also possible that chronic PCB exposure may have suppressed and weakened the immuno systems of exposed fish making them more vulnerable to secondary parasitic infection.
Smeets, Bart; Angelotti, Maria Lucia; Rizzo, Paola; Dijkman, Henry; Lazzeri, Elena; Mooren, Fieke; Ballerini, Lara; Parente, Eliana; Sagrinati, Costanza; Mazzinghi, Benedetta; Ronconi, Elisa; Becherucci, Francesca; Benigni, Ariela; Steenbergen, Eric; Lasagni, Laura; Remuzzi, Giuseppe; Wetzels, Jack; Romagnani, Paola
Glomerular injury can involve excessive proliferation of glomerular epithelial cells, resulting in crescent formation and obliteration of Bowman's space. The origin of these hyperplastic epithelial cells in different glomerular disorders is controversial. Renal progenitors localized to the inner surface of Bowman's capsule can regenerate podocytes, but whether dysregulated proliferation of these progenitors contributes to crescent formation is unknown. In this study, we used confocal microscopy, laser capture microdissection, and real-time quantitative reverse transcriptase-PCR to demonstrate that hypercellular lesions of different podocytopathies and crescentic glomerulonephritis consist of three distinct populations: CD133(+)CD24(+)podocalyxin (PDX)(-)nestin(-) renal progenitors, CD133(+)CD24(+)PDX(+)nestin(+) transitional cells, and CD133(-)CD24(-)PDX(+)nestin(+) differentiated podocytes. In addition, TGF-beta induced CD133(+)CD24(+) progenitors to produce extracellular matrix, and these were the only cells to express the proliferation marker Ki67. Taken together, these results suggest that glomerular hyperplastic lesions derive from the proliferation of renal progenitors at different stages of their differentiation toward mature podocytes, providing an explanation for the pathogenesis of hyperplastic lesions in podocytopathies and crescentic glomerulonephritis.
Sylvester, John E.; Grimm, Peter D.; Blasko, John C.; Millar, Jeremy; Orio, Peter F.; Skoglund, Scott; Galbreath, Robert W.; Merrick, Gregory
Purpose: Long-term biochemical relapse-free survival (BRFS) rates in patients with clinical Stages T1-T3 prostate cancer continue to be scrutinized after treatment with external beam radiation therapy and brachytherapy. Methods and Materials: We report 15-year BRFS rates on 223 patients with clinically localized prostate cancer that were consecutively treated with I 125 or Pd 103 brachytherapy after 45-Gy neoadjuvant EBRT. Multivariate regression analysis was used to create a pretreatment clinical prognostic risk model using a modified American Society for Therapeutic Radiology and Oncology consensus definition (two consecutive serum prostate-specific antigen rises) as the outcome. Gleason scoring was performed by the pathologists at a community hospital. Time to biochemical failure was calculated and compared by using Kaplan-Meier plots. Results: Fifteen-year BRFS for the entire treatment group was 74%. BRFS using the Memorial Sloan-Kettering risk cohort analysis (95% confidence interval): low risk, 88%, intermediate risk 80%, and high risk 53%. Grouping by the risk classification described by D'Amico, the BRFS was: low risk 85.8%, intermediate risk 80.3%, and high risk 67.8% (p = 0.002). Conclusions: I 125 or Pd 103 brachytherapy combined with supplemental EBRT results in excellent 15-year biochemical control. Different risk group classification schemes lead to different BRFS results in the high-risk group cohorts
Full Text Available O ensaio resgata a vivência brasileira de Adolfo Celi, ator e diretor italiano ativo em cinema e teatro (1922-1986, inserido no laboratório paulista da renovação, na década de 1950. Sua atuação impôs, no palco, o legado texto-cêntrico de Sílvio d'Amico e a utopia do ator plástico de Copeau e, na tela, a estética neo-realista associada a uma atuação fortemente marcada pelo ideário teatral moderno. As intuições, a herança, as oportunidades e as invenções perdidas desta experiência transcultural sugerem um quadro de realização somente parcial do projeto modernizador. Ao entrar na década de 60, é a sensação de ter esgotado um ciclo existencial que fornece a Celi um válido álibi para o retorno. Álibi (1969, seu terceiro e último filme como diretor, realizado na Itália com Gassmann e Lucignani, é um testemunho de vida e memórias, de raiva e de saudade do Brasil; e um precioso guia para entender sua extraordinária ‘aventura americana’.
Fernandez-Gomez, J M; Eiro, N; García-Rodríguez, J J; Quintás-Blanco, A; Gonzalez-Ruiz de León, C; Perez de Haro, M L; Vizoso-Piñero, F
To analyze the expression of metalloprotein 11 (MMP11) in cultured fibroblasts obtained from human prostate tumors with different clinical and pathological characteristics. For this study we analyzed samples of transrectal prostate biopsies from tumors with different characteristics, treated with or whithout androgen deprivation (AD). After optimization of the culture method, fibroblasts were isolated and cultured to perform the study (PCR) of MMP11 mRNA. Finally, 37 cases were studied: 5 samples of benign prostatic hyperplasia, 14 cases with localized neoplasms (7 high-risk according to the D'Amico classification), 5 with metastasic tumors (bone metastases), and 13 treated with AD therapy, of which 6 fulfilled the requirements to be defined as resistant to castration. In tumors without AD therapy, MMP11 expression was significantly higher (P=.001) in fibroblasts of higher grade tumors. A significant (P=.001) correlation was found between PSA and expression of MMP11 in fibroblast s and a significant increase of MMP11 expression in metastatic tumors. In tumors with AD therapy, a significantly greater expression of MMP11 was observed in resistant to castration patients than in those sensitive to castration (P=.003). In advanced prostate tumors or in stages of increased tumor aggressiveness, the production of MMP11 by fibroblasts is significantly greater than in non-metastatic tumors or in AD sensitive tumors. Copyright © 2016 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.
Full Text Available Francesca Anzellotti, Raffaella Franciotti, Holta Zhuzhuni, Aurelio D'Amico, Astrid Thomas, Marco Onofrj Department of Neuroscience and Imaging, Aging Research Centre, Gabriele d'Annunzio University Foundation, Gabriele d'Annunzio University, Chieti, Italy Abstract: Nonepileptic seizures (NES apparently look like epileptic seizures, but are not associated with ictal electrical discharges in the brain. NES constitute one of the most important differential diagnoses of epilepsy. They have been recognized as a distinctive clinical phenomenon for centuries, and video/electroencephalogram monitoring has allowed clinicians to make near-certain diagnoses. NES are supposedly unrelated to organic brain lesions, and despite the preponderance of a psychiatric/psychological context, they may have an iatrogenic origin. We report a patient with NES precipitated by levetiracetam therapy; in this case, NES was observed during the disappearance of epileptiform discharges from the routine video/electroencephalogram. We discuss the possible mechanisms underlying NES with regard to alternative psychoses associated with the phenomenon of the forced normalization process. Keywords: nonepileptic seizures, forced normalization, levetiracetam, behavioral side effects
Cérebro, linguagem e funcionamento cognitivo na perspectiva sócio-histórico-cultural: inferências a partir do estudo das afasias = Brain, language and cognitive functioning in the social-historical-cultural approach: inferences from the study of aphasia
Novaes-Pinto, Rosana do Carmo
Full Text Available Este artigo visa apresentar e discutir, criticamente, (i os princípios teóricos das abor- dagens sócio-histórico-culturais que guiam a pesquisa acadêmica no campo da Neurolinguística de orientação enunciativo-discursiva, mobilizando postulados fundamentais de Vygotsky e Luria, com relação ao funcionamento cerebral, bem como reflexões de Coudry, Franchi e Novaes-Pinto, no que concerne à concepção e funcionamento de linguagem; (ii questões metodológicas relativas às pesquisas qualitativas dos fenômenos afasiológicos, respaldadas pelos trabalhos de Freitas, Damico et al. , dentre outros; e, finalmente, (iii como os estudos de casos e as análises qualitativas contribuem para as pesquisas no âmbito da Neurolinguística, que visam compreender aspectos do funcionamento cognitivo e a relação entre cérebro e linguagem
Joana Maria Eleutério
Full Text Available This article aims to analyze the film Ônibus Linha 174 (José Padilha, 2002 as another interpretation of the episode narrated and commented based on a variety of texts. The film is a documentary, which was produced by Jose Padilha (also director and Marcos Prado, photography by Cesar Morales and Marcelo Guru and editing by Felipe Lacerda. The film focuses on urban violence, but this article discusses other issues, avoiding the repetition of what has already been said by great experts and even ordinary citizens. This film, the foundation of my research, is the guideline to the reflection that I propose, since the focus of my analysis the main character of two parallel stories narrated in the film: the young Sandro Rosa do Nascimento, who becomes an archetypal figure in the social context of stories, scenarios and the testimonies shown by Padilha. As the discussion progresses, another important character for the analysis emerges: Sandra Mara Herzer (1962-1982, a young woman whose life trajectory allows me to compare the two aiming to understand how these two characters who report a serious context that causes the multiplication of a series of other stories similar to theirs. It is unquestionable that, although both have achieved international visibility, there is a multitude of invisible Sandros and Sandras, living in the streets and "caregivens" institutions for children, going through the same stages of this monstrous metamorphosis that led them desperation in the final scene of their short lives.
When a group of physicists entered the Main Auditorium, during the evening of 29 June, they felt they had opened a time portal. Paul Dirac in front of a blackboard showing his formula. ©Sandra Hoogeboom An attentive audience, dressed in early 1900 costumes, were watching a lecture by the elusive Paul Dirac, presenting for the first time his famous formula on the blackboard. Paul Adrien Maurice Dirac (1902-1984) was a British mathematical physicist at Cambridge, and one of the "fathers" of quantum mechanics. When he first wrote it, in 1928, Dirac was not sure what his formula really meant. As demonstrated by Andersson four year later, what Dirac had written on the blackboard was the first definition of a positron, hence he is credited with having anticipated the existence of antimatter. The actor John Kohl performs as Paul Dirac. ©Sandra Hoogeboom What the group of puzzled physicists were really observing when they entered the CERN Auditorium was the shoo...
The studies into stresses and deformations in the core are mainly focused on the fuel rod and the fuel assembly can. In high neutron doses austenitic steel swells and this is associated with a considerable increase in the volume of material. The SANDRA computer program is used for solving the problems of can deformations and stress during long-term reactor operation. The block for the mechanical interaction of cans is the key part of the program. The program input data include temperature distribution, fast neutron flux distribution and coolant overpressure inside the cans. Reactor operation is modelled using operating modes A, B, C which may arbitrarily be combined. Mode A computes bending deformations and the deformations of the can cross-section due to temperature dilatation in the change in temperature fields in the reactor; mode B computes deformations due to swelling and creep in long-term operation; mode C computes thermal deformations in reactor shut-down. A flowsheet is shown of program SANDRA as are examples of computed deformations. (M.S.)
Wang, Xiao-Gang; Carrington, Tucker
Large amplitude vibrations of Van der Waals clusters are important because they reveal large regions of a potential energy surface (PES). To calculate spectra of Van der Waals clusters it is common to use an adiabatic approximation. When coupling between intra- and inter-molecular coordinates is important non-adiabatic coupling cannot be neglected and it is therefore critical to develop and test theoretical methods that couple both types of coordinates. We have developed new product basis and contracted basis Lanczos methods for Van der Waals complexes and tested them by computing rovibrational energy levels of Cl^-H_2O. The new product basis is made of functions of the inter-monomer distance, Wigner functions that depend on Euler angles specifying the orientation of H_2O with respect to a frame attached to the inter-monomer Jacobi vector, basis functions for H_2O vibration, and Wigner functions that depend on Euler angles specifying the orientation of the inter-monomer Jacobi vector with respect to a space-fixed frame. An advantage of this product basis is that it can be used to make an efficient contracted basis by replacing the vibrational basis functions for the monomer with monomer vibrational wavefunctions. Due to weak coupling between intra- and inter-molecular coordinates, only a few tens of monomer vibrational wavefunctions are necessary. The validity of the two new methods is established by comparing energy levels with benchmark rovibrational levels obtained with polyspherical coordinates and spherical harmonic type basis functions. For all bases, product structure is exploited to calculate eigenvalues with the Lanczos algorithm. For Cl^-H_2O, we are able, for the first time, to compute accurate splittings due to tunnelling between the two equivalent C_s minima. We use the PES of Rheinecker and Bowman (RB). Our results are in good agreement with experiment for the five fundamental bands observed. J. Rheinecker and J. M. Bowman, J. Chem. Phys. 124 131102
Saxena, Indu Fiesler; Hui, Kaleo; Astrahan, Melvin
Measuring tissue temperature distribution during electromagnetically induced hyperthermia (HT) is challenging. High resistance thermistors with nonmetallic leads have been used successfully in commercial HT systems for about three decades. The single 1 mm thick temperature sensing element is mechanically moved to measure tissue temperature distributions. By employing a single thermometry probe containing a fixed linear sensor array temperature, distributions during therapy can be measured with greater ease. While the first attempts to use fiber Bragg grating (FBG) technology to obtain multiple temperature points along a single fiber have been reported, improvement in the detection system's stability were needed for clinical applications. The FBG temperature sensing system described here has a very high temporal stability detection system and an order of magnitude faster readout than commercial systems. It is shown to be suitable for multiple point fiber thermometry during microwave hyperthermia when compared to conventional mechanically scanning probe HT thermometry. A polymer coated fiber Bragg grating (PFBG) technology is described that provides a number of FBG thermometry locations along the length of a single optical fiber. The PFBG probe developed is tested under simulated microwave hyperthermia treatment to a tissue equivalent phantom. Two temperature probes, the multiple PFBG sensor and the Bowman probe, placed symmetrically with respect to a microwave antenna in a tissue phantom are subjected to microwave hyperthermia. Measurements are made at start of HT and 85 min later, when a 6 degrees C increase in temperature is registered by both probes, as is typical in clinical HT therapy. The optical fiber multipoint thermometry probe performs highly stable, real-time thermometry updating each multipoint thermometry scan over a 5 cm length every 2 s. Bowman probe measurements are acquired simultaneously for comparison. In addition, the PFBG sensor's detection
Prunet, Nathanaël; Jack, Thomas P
The field of Arabidopsis flower development began in the early 1980s with the initial description of several mutants including apetala1, apetala2, and agamous that altered floral organ identity (Koornneef and van der Veen, Theor Appl Genet 58:257-263, 1980; Koornneef et al., J Hered 74:265-272, 1983). By the end of the 1980s, these mutants were receiving more focused attention to determine precisely how they affected flower development (Komaki et al., Development 104:195-203, 1988; Bowman et al., Plant Cell 1:37-52, 1989). In the last quarter century, impressive progress has been made in characterizing the gene products and molecular mechanisms that control the key events in flower development. In this review, we briefly summarize the highlights of work from the past 25 years but focus on advances in the field in the last several years.
Guggi, Davide; Kast, Constantia E; Bernkop-Schnürch, Andreas
To develop and evaluate an oral delivery system for salmon calcitonin. 2-Iminothiolane was covalently bound to chitosan in order to improve the mucoadhesive and cohesive properties of the polymer. The resulting chitosan-TBA conjugate (chitosan-4-thiobutylamidine conjugate) was homogenized with salmon calcitonin. mannitol, and a chitosan-Bowman-Birk inhibitor conjugate and a chitosan-elastatinal conjugate (6.75 + 0.25 + 1 + 1 + 1). Optionally 0.5% (m/m) reduced glutathione. used as permeation mediator, was added. Each mixture was compressed to 2 mg microtablets and enteric coated with a polymethacrylate. Biofeedback studies were performed in rats by oral administration of the delivery system and determination of the decrease in plasma calcium level as a function of time. Test formulations led to a significant (p thiolated chitosan, chitosan-enzyme-inhibitor conjugates and the permeation mediator glutathione seems to represent a promising strategy for the oral delivery of salmon calcitonin.
Tiernan, T.; Entine, G.; Stump, D.A.; Prough, D.S.
A very portable, regional cerebral blood flow (rCBF) analysis instrument system suitable for use in the operating theater during surgery is under development. Cadmium telluride (CdTe) solid state radiation detectors, an 8086 based data acquisition and communications module and a DEC Microvax computer are used so that the instrument is very compact, yet has the computational power to provide real time data analysis in the clinical environment. The instrument is currently being used at Bowman Gray School of Medicine to study rCBF during cardiopulmonary bypass surgery (CPB). Preliminary studies indicate that monitoring rCBF during this surgical procedure may provide insights into the mechanism that causes a significant fraction of these patients to suffer post operative neuropsychological deficit
This Tank Sampling and Analysis Plan (TSAP) identifies sample collection, laboratory analysis, quality assurance/quality control (QA/QC), and reporting objectives for the characterization of tank 241-AP-108 waste. Technical bases for these objectives are specified in the 242-A Evaporator Data Quality Objectives (Bowman 2000 and Von Bargen 1998) and 108-AP Tank Sampling Requirements in Support of Evaporator Campaign 2000-1 (Le 2000). Evaporator campaign 2000-1 will process waste from tank 241-AP-108 in addition to that from tank 241-AP-107. Characterization results will be used to support the evaporator campaign currently planned for early fiscal year 2000. No other needs (or issues) requiring data for this tank waste apply to this sampling event
Andersen, Torben J.; Bettis, Richard A.
We study a longitudinal fit model of adaptation and its association with the longitudinal risk-return relationship. The model allows the firm to adjust its position in response to partial learning about a changing environment characterized by two path-dependent processes—a random walk and a stoch......We study a longitudinal fit model of adaptation and its association with the longitudinal risk-return relationship. The model allows the firm to adjust its position in response to partial learning about a changing environment characterized by two path-dependent processes—a random walk...... can lead to the inverse longitudinal risk-return relationships observed empirically. We discuss this apparent paradox and the possible resolution between mindless and conscious behavior as plausible causes of the longitudinal Bowman Paradox....
Viktor A. Nedovic
Full Text Available This study describes the relationship between the two major trypsin inhibitors (TI in soybean, i.e., the Kunitz (KTI and Bowman-Birk (BBI trypsin inhibitors, as well as between them and the corresponding trypsin inhibitor activity (TIA. Twelve investigated soybean genotypes showed significant differences in TI levels and TIA. A very strong positive correlation was found between the levels of KTI and total BBI (r = 0.94, P < 0.05. No relationship was found between KTI, BBI or total TI and TIA. Based on this data, it appears that the levels of major TI in soybean are related. Understanding the relationship between trypsin inhibitors and their activities could be useful for further improvement of the health impacts of soy proteins.
Baba, Hiroshi; Kudo, Tomoo; Makino, Yoshinori; Mochizuki, Yasumasa; Takagi, Takayo; Une, Yumi
Spontaneous crescentic glomerulonephritis (CrGN) in animals has only been reported in dog and sheep. We report the pathological features of CrGN in a 17-year-old male polar bear that died due to renal failure. Histologically, the lesions were characterized by fibrocellular crescents, adhesion between Bowman's capsule and the glomerular capillary tuft and an increase in the mesangial matrix in glomeruli. The proliferating cells in the crescent were partly immunopositive for cytokeratin and intensely positive for vimentin, WT-1 and α-smooth muscle actin, suggesting they originated from parietal epithelial cells. Ultrastructually, thickening of the glomerular basement membrane and loss of epithelial cell foot processes were observed with electron-dense deposits.
Silverman, Mark E; Upshaw, Charles B
In his landmark "Gulstonian Lectures on Malignant Endocarditis," published in 1885, William Osler commented, "Few diseases present greater difficulties in the way of diagnosis than malignant endocarditis, difficulties which in many cases are practically insurmountable." At that time, the fields of microbiology and blood cultures were in their infancy, and the diagnosis was made premortem in just half the patients with the condition. After Osler's report, extracardiac physical findings became essential clues to earlier diagnosis. Today, infective endocarditis is most commonly suggested from the history and often clinched by an echocardiogram and blood cultures. Although prized physical manifestations are much less frequent now, they still do occur and may be an invaluable clue that leads to earlier, more effective treatment. The investigators review these extracardiac findings along with their historical descriptions: splinter hemorrhages, emboli, Osler's nodes, Janeway and Bowman lesions of the eye, Roth spots, petechiae, and clubbing.
Berndsen, Zachary; Bowman, Charles; Jang, Haerin; Ward, Andrew B
The Electron Microscopy Hole Punch (EMHP) is a streamlined suite of tools for quick assessment, sorting and hole masking of electron micrographs. With recent advances in single-particle electron cryo-microscopy (cryo-EM) data processing allowing for the rapid determination of protein structures using a smaller computational footprint, we saw the need for a fast and simple tool for data pre-processing that could run independent of existing high-performance computing (HPC) infrastructures. EMHP provides a data preprocessing platform in a small package that requires minimal python dependencies to function. https://www.bitbucket.org/chazbot/emhp Apache 2.0 License. email@example.com. Supplementary data are available at Bioinformatics online. © The Author(s) 2017. Published by Oxford University Press.
Rao, Srinivas K; Fan, Dorothy S P; Pang, C P; Li, Winnie W Y; Ng, Joan S K; Good, William V; Lam, Dennis S C
To report the unusual association of bilateral corneal keloids and anterior segment mesenchymal dysgenesis in a child with Rubinstein-Taybi syndrome. Case report of a 2-year-old boy. Excision of the epicorneal mass in the right eye was followed by recurrence of the lesion. Multiple penetrating keratoplasties were unsuccessful in reconstructing the anterior segment because of recurrent corneal epithelial breakdown, suggesting limbal stem cell insufficiency. Histopathology and electron microscopy of the excised mass lesion showed features typical of a corneal keloid: thickened keratinized epithelium, absent Bowman's layer, and fibrovascular hyperplasia, with haphazard orientation of the collagen lamellae. Ultrasound biomicroscopy and intraoperative findings suggested a diagnosis of Peter anomaly, but genetic analysis did not show a PAX6 mutation. The findings in our patient add to the spectrum of ocular changes described in Rubinstein-Taybi syndrome and confirm earlier reports of poor ocular prognosis in corneal keloids and Rubinstein-Taybi syndrome.
Song, Jong-Suk; Kwon, Sangwon; Shyn, Kyung-Hwan
To describe a case of unilateral comeal keloid and present the clinical and histopathological findings and the management. A 23-year-old Asian male patient was examined for a white spot on the left cornea that had been present since birth. On biomicroscopic examination, a well-demarcated vascularized comeal mass was found located nasal to the center. The pupil was displaced superiorly, and gonioscopic examination showed peripheral iridocomeal adhesion at 12 o'clock. The patient underwent penetrating keratoplasty. Histopathologic study showed a variously thickened epithelial layer, an absence of Bowman's layer, subepithelial fibrovascular hyperplasia, and an absence of dermal elements. These histopathologic findings suggested a congenital comeal keloid. The central graft comea remained clear at 18 months after surgery and the patient was satisfied with the result. Penetrating keratoplasty may be an effective surgical option for congenital keloids in young adult patients.
Alkatan, Hind M; Al-Arfaj, Khalid M; Hantera, Mohammed; Al-Kharashi, Soliman
We are reporting a 34-year-old Arabic white female patient who presented with a white mass covering her left cornea following multiple ocular surgeries and healed corneal ulcer. The lesion obscured further view of the iris, pupil and lens. The patient underwent penetrating keratoplasty and the histopathologic study of the left corneal button showed epithelial hyperplasia, absent Bowman's layer and subepithelial fibrovascular proliferation. The histopathologic appearance was suggestive of a corneal keloid which was supported by further ultrastructural study. The corneal graft remained clear 6 months after surgery and the patient was satisfied with the visual outcome. Penetrating keratoplasty may be an effective surgical option for corneal keloids in young adult patients.
Campos Néstor Hernando
Full Text Available La subfamilia Tymolinae fue elevada recientemente a la categoría de familia, separándola de la Dorippidae, de acuerdo con lo expuesto por Wear & Batham (1975 y asumido por Bowman & Abele (1982 Y Williams (1984. La familia Tymolidae está constituida por un grupo de cangrejos, cercanos sistemáticamente a la familia Dromiacea, dentro de la que se destacan los del género Clythrocerus. A pesar de ser un grupo dedistribución tropical principalmente (Wear & Batam, 1975, no había sido registrada ninguna especie para el Caribe colombiano.
This report summarises the findings of a project to further develop and improve a system based on the Bowman TG50 50kWe turbine and a C3(S) combustor with a high temperature heat exchanger for the production of electricity from biomass. Details are given of the specific aims of the project, the manufacture of a new larger biomass combustor, the development of startup and shutdown procedures, waste heat recuperation, adaption of a PC-based mathematical model, and capital equipment costs. The significant levels of carbon emission savings and the commercial prospects of the biomass generator gas turbine combined heat and power (CHP) system are considered, and recommendations are presented.
Xiong Jing; Wang Yang; Zhu, Zhonghua; Liu Jianshe; Wang Yumei; Zhang Chun; Hammes, Hans-Peter; Lang, Florian; Feng Yuxi
As a membrane-spanning protein, NG2 chondroitin sulfate proteoglycan interacts with molecules on both sides of plasma membrane. The present study explored the role of NG2 in the pathogenesis of diabetic nephropathy. In the normal kidneys, NG2 was observed predominantly in glomerular mesangium, Bowman's capsule and interstitial vessels. Both mRNA and protein expression in kidneys was significantly higher in strepozotocin-induced diabetic rats than that in normal rats. In the cultured rat mesangial cell line HBZY-1, overexpression of NG2 promoted mesangial cell proliferation and extracellular matrix (ECM) production, such as type VI collagen and laminin. Furthermore, target knockdown of NG2 resulted in decreased cell proliferation and ECM formation. The observations suggest that NG2 is up-regulated in diabetic nephropathy. It actively participates in the development and progression of glomerulosclerosis by stimulating proliferation of mesangial cells and deposition of ECM
Full Text Available Milking speed is defined as the time required to milk a cow (Bowman et al., 1996. Milkability can be considered an important functional trait in dairy cattle for udder health (Dodenhoff et al., 1999 and workability (Visscher and Goddard, 1995. Sivarajasingam et al. (1984, found milking speed to be the third most important trait on net profit for dairy farms, after milk yield and fat content, so much so that it is included in breeding programmes for dairy cattle (Schneeberger and Hagger, 1985; Boettcher et al., 1997. Different methods to measure milkability traits, subjective and instrumental, were reported in the literature. Meyer and Burnside (1987 found a high genetic correlation between a subjective evaluations of milking speed of cows by Canadian farmers (using five classes: 1 = “very slow” ... 5 = “very fast”, with total milking time by chronometer.......
Full Text Available Grain of conventional soybean varieties requires heat processing to break down trypsin inhibitor's activity before using as food or animal feed. At the same time, protein denaturation and other qualitative changes occur in soybean grain, especially if the temperature of heating is not controlled. Two types of trypsin inhibitor were found in soybean grain the Kunitz trypsin inhibitor and the Bowman-Birk inhibitor. Mature grain of soybean Laura is lacking Kunitz trypsin inhibitor. Grain yield of variety Laura is equal to high yielding varieties from the maturity group I, where it belongs. Lacking of Kunitz-trypsin inhibitor makes soybean grain suitable for direct feeding in adult non ruminant animals without previous thermal processing. Grain of variety Laura can be processed for a shorter period of time than conventional soybeans. This way we save energy, and preserve valuable nutritional composition of soybean grain, which is of interest in industrial processing.
Torres-Salinas, D.; Robinson-Garcia, N.; Jimenez-Contreras, E.
Social media based indicators or altmetrics have been under scrutiny for the last seven years. Their promise as alternative metrics for measuring scholarly impact (Priem, Piwowar, & Hemminger, 2012) is still far from becoming a reality (Torres-Salinas, Cabezas-Clavijo, & Jiménez-Contreras, 2013). Issues with regard to their meaning (Sud & Thelwall, 2014), potential use as alternative or complements to citation indicators (Bornmann, 2014; Costas, Zahedi, & Wouters, 2015a), data collection inconsistencies (Robinson-García, Torres-Salinas, Zahedi, & Costas, 2014) or diversity of sources (Thelwall, Haustein, Larivière, & Sugimoto, 2013) are still under development. In this regard, three lines of work can be observed in regard to altmetric studies: 1) the relation between citations and altmetric indicators (Costas et al., 2015a), 2) their meaning as impact indicators (i.e., Bornmann, 2014; Haustein, Bowman, & Costas, 2015), and, 3) coverage and diversity of social media sources (i.e., Haustein, 2016). (Author)
Mazlin, Viacheslav; Xiao, Peng; Dalimier, Eugénie; Grieve, Kate; Irsch, Kristina; Sahel, José-Alain; Fink, Mathias; Boccara, A Claude
We present the first full-field optical coherence tomography (FFOCT) device capable of in vivo imaging of the human cornea. We obtained images of the epithelial structures, Bowman's layer, sub-basal nerve plexus (SNP), anterior and posterior stromal keratocytes, stromal nerves, Descemet's membrane and endothelial cells with visible nuclei. Images were acquired with a high lateral resolution of 1.7 µm and relatively large field-of-view of 1.26 mm x 1.26 mm - a combination, which, to the best of our knowledge, has not been possible with other in vivo human eye imaging methods. The latter together with a contactless operation, make FFOCT a promising candidate for becoming a new tool in ophthalmic diagnostics.
Brigmon, R.L.; Franck, M.; Brey, J.; Scott, D.; Lanclos, K.; Fliermans, C.
Historically, methods used to identify methanotrophic and polyaromatic hydrocarbon-degrading (PAH) bacteria in environmental samples have been inadequate because isolation and identification procedures are time-consuming and often fail to separate specific bacteria from other environmental microorganisms. Methanotrophic bacteria have been isolated and characterized from TCE-contaminated soils (Bowman et al. 1993; Fliermans et al., 1988). Fliermans et al., (1988) and others demonstrated that cultures enriched with methane and propane could cometabolically degrade a wide variety of chlorinated aliphatic hydrocarbons including ethylene; 1,2-cisdichloroethylene (c-DCE); 1,2-trans-dichloroethylene (t-DCE); vinyl chloride (VC); toluene; phenol and cresol. Characterization of select microorganisms in the natural setting is important for the evaluation of bioremediation potential and its effectiveness. This realization has necessitated techniques that are selective, sensitive and easily applicable to soils, sediments, and groundwater (Fliermans, et al., 1994). Additionally these techniques can identify and quantify microbial types in situ in real time
Shamseldeen, Asmaa Mohammed; Ali Eshra, Mohammed; Ahmed Rashed, Laila; Fathy Amer, Marwa; Elham Fares, Amal; Samir Kamar, Samaa
Maternal diet composition could influence fetal organogenesis. We investigated effects of high fat diet (HFD) intake alone or combined with omega 3 during pregnancy, lactation and early days of weaning on nephrogenesis of pups and maternal renal function and morphology. Mothers and their pups included in each group were supplied with the same diet composition. Rats were divided into group I, II and III supplied with chow of either 10 kcal%, 45 kcal% or 45 kcal% from fat together with omega-3 respectively. Group II showed increased serum urea and creatinine, renal TNF-α, IL1β. Structural injury was observed in mothers and their pups as Bowman's capsule and tubular dilatation and increased expression of PCNA that were decreased following omega-3 supplementation added to down regulation of Wnt4, Pax2 gene and podocin expression. Omega-3 supplementation improves lipid nephrotoxicity observed in mothers and their pups.
Inomata, Taisuke; Itoh, Satoshi; Tsuboi, Nobuaki
Guinea pigs were divided into groups according to four irradiation schedules : 2 Gy/3 Gy x 1/day, five fractions/week, total 80 Gy/81 Gy (A/C group) and 1.0 Gy/1.5 Gy x 2/day, ten fractions/week, total 80 Gy/81 Gy (B/D group). The A group and the C group pathologically caused severe damage in the kidney six and three months after irradiation, respectively. In the B group pathological analysis suggested that only slight-to-moderate changes were occurred in the Bowman's capsule. The D group caused slight damage in the kidney six months after irradiation. Hyperfractionation (B/D group) used in this protocol can clearly reduce radiation damage in the kidney of guinea pigs as compared with conventional fractionation (A/C group). (author)
Prevalência e aspectos anatomopatológicos da mineralização metastática em coelhos provenientes de biotérios e criação comercial do Estado do Rio de Janeiro, Brasil Prevalence and morphological aspects of metastatic mineralization in rabbits from animal houses and a comercial breeding in the state of Rio de Janeiro, Brazil
Alessandra Santos Almeida Matias
Full Text Available Uma investigação sobre a prevalência e os aspectos anatomopatológicos de casos naturais da mineralização metastática em coelhos (Oryctolagus cuniculus foi realizada em 79 animais provenientes de dois biotérios de criação (A e B e de uma criação comercial, do Estado do Rio de Janeiro. A ração comercial fornecida aos animais dos três criatórios foi a mesma. Apenas animais do biotério A, com uma prevalência de 21%, apresentaram alterações macroscópicas e microscópicas relacionadas à mineralização metastática. Todos os coelhos acometidos possuíam idade acima de 1 ano e 92% eram fêmeas. Os órgãos mais freqüentemente atingidos foram a artéria aorta e principais ramos, que apresentavam mineralização das túnicas íntima e média, metaplasia cartilaginosa e óssea na túnica média, arterite granulomatosa e degeneração hialina. Os rins foram o segundo órgão mais comumente acometido, mostrando mineralização da cápsula de Bowman, distensão do espaço de Bowman, fibrose intersticial e mineralização da parede, dos túbulos contornados e dos ductos coletores. As alterações patológicas foram similares às observadas nos casos de hipervitaminose D, excesso de cálcio e fósforo na dieta de coelhos, devendo os níveis dessas substâncias serem revistos e analisados periodicamente nas rações comerciais desses animais.A survey on the prevalence and morphological aspects of natural cases of metastatic mineralization was performed in 79 rabbits from two breeding animal houses (A and B and from a commercial rabbit breeding facility in the state of Rio de Janeiro. Rabbits from the three facilities were fed with the same commercial ration. Only rabbits from the facility A presented gross and microscopic alterations associated with metastatic mineralization with a prevalence of 21%. All of the affected rabbits were older than one year old and 92% were females. The most altered organs were the aorta and its main branches
Metcalf, D.; Nicola, N.A.
The hemopoietic regulator multipotential colony-stimulating factor [Multi-CSF (interleukin 3)] has proliferative effects on a wide range of hemopoietic cells in vitro and in vivo. Native or recombination Multi-CSF injected intravenoulsy into adult mice had an initial half-life of 3-5 min and a second phase of 50 min. Clear labeling of hemopoietic cells was observed in the bone marrow and spleen of mice injected intravenously with recombinant 125 I-labeled Multi-CSF showing that injected Multi-CSF can obtain access to such cells in situ. A high proportion of injected 125 I-labeled Multi-CSF of both types became localized in the liver and in the kidney (in cells of the Bowman's capsule and proximal renal tubules). The kidney appeared to be an active site of degradation of Multi-CSF with the early appearance of low molecular weight labeled material in the urine
Pokorny, L.; Kelemen, J.
A possible application of the non-ionizing contrast material metrizamid (Amipaque Vascularsup(R), Amipaquesup(R)) for renal angiography was experimentally investigated in dogs. 1.5, 3, 10 or 25 ml contrast medium was injected into one kidney. The animals were killed immediately, 3 hours, 24 hours, 7 or 28 days after angiography, and the kidneys were histologically investigated. In several cases the angiograms showed small alterations (transitory vasospasm, inhomogeneous spots on the nephrogram). Histology revealed in the initial period a homogeneous, pinkish, protein-like substance in the Bowman capsule and in the lumen of the tubuli, whereas later infiltrations by round cells and local accumulation of connective tissues were found. (L.E.)
Masters, Barry R.
A real-time clinical confocal light microscope provides the ophthalmologist with a new tool for the observation of the cornea and the ocular lens. In addition, the ciliary body, the iris, and the sclera can be observed. The real-time light microscopic images have high contrast and resolution. The transverse resolution is about one half micron and the range resolution is one micron. The following observations were made with visible light: corneal epithelial cells, wing cells, basal cells, Bowman's membrane, nerve fibers, basal lamina, fibroblast nuclei, Descemet's membrane, endothelial cells. Observation of the in situ ocular lens showed lens capsule, lens epithelium, lens fibrils, the interior of lens fibrils. The applications of the confocal microscope include: eye banking, laser refractive surgery, observation of wound healing, observation of the iris, the sciera, the ciliary body, the ocular lens, and the intraocular lens. Digital image processing can produce three-dimensional reconstructions of the cornea and the ocular lens.
Saenphet, S.; Thaworn, W.; Saenphet, K. [Chiang Mai University, Chiang Mai (Thailand). Faculty of Science
The acidity of mine water generally makes it toxic to most organisms. The gills, kidneys and livers of Anabas testudineus Bloch fish inhabiting the acidic water (pH 2-4) of an unused lignite mine in Li District, Lamphun Province, Thailand were examined and compared to those of farmed fish. Tissue abnormalities were found in all investigated organs. Deterioration and telangiectasia of gill filaments were found. Liver tissue revealed hemorrhages, blood congestion and necrotic cells with mononuclear cell infiltration. In addition, hypertrophy of the epithelial cells of the renal tubules with reduced lumens, aneurisms of the renal tubules, and contractions of the glomeruli in the Bowman's capsule were observed. These histopathological findings suggest the acidic water in this habitat causes severe damage to the internal organs of fish and consequently alter their physiological status. Since the water in this pond is utilized by local people, these findings highlight the need for adequate water treatment.
Leung, Janet Y; Kim, William Y
Large genome sequencing efforts have identified frequent mutations in the histone-modifying and chromatin-remodeling genes BAP1 and PBRM1 in clear cell renal cell carcinoma (ccRCC). In this issue of Cancer Discovery , Gu and colleagues model these genetic events in mice and report that dual inactivation of Vhl with either Bap1 or Pbrm1 results in faithful genetically engineered murine models of ccRCC. Moreover, their work establishes that Bap1 and Pbrm1 are determinants of tumor grade and mTORC1 activation and provocatively suggests that the cell of origin of ccRCC may lie in PAX8-expressing Bowman capsule cells. Cancer Discov; 7(8); 802-4. ©2017 AACR See related article by Gu et al., p. 900 . ©2017 American Association for Cancer Research.
Nickavar, Azar; Rahbar, Mahtab
There is little information about the clinicopathological correlations of focal segmental glomerulosclerosis (FSGS) in children. Renal biopsies of 46 patients with primary FSGS were reviewed between 1994 and 2015. Clinical and laboratory findings were evaluated at the time of renal biopsy. Totally, not otherwise specified (NOS) was the most common pathologic variant in 38 patients. There was no correlation between age, gender, serum protein, urine protein, hematuria, and steroid response with five distinct pathologic variants and histopathologic lesions. Hgb level had a negative correlation to the glomerular hyalinosis, mesengial hypercellularity, mesengial deposition, and glomerular volume. Renal dysfunction and blood pressure had a significant positive association with the extent of tubular atrophy, interstitial fibrosis, synechiae in Bowman capsule, arteriolar hyalinosis, mononuclear infiltration, atherosclerosis, glomerular hyalinosis, mesengial hypercellularity, mesengial deposition, and glomerular sclerosis. In conclusion, serum creatinine and blood pressure were the significant predictors of histopathologic lesions in children with primary FSGS.
Matsuzaki, Keiichi; Ohsawa, Isao; Nishitani, Tomohito; Takeda, Yukihiko; Inoshita, Hiroyuki; Ishii, Masaya; Takagi, Miyuki; Horikoshi, Satoshi; Tomino, Yasuhiko
A 55-year-old woman presented with heavy proteinuria (6.2 g/day) in April 2007. Because monoclonal IgG-k was detected in serum and urine samples, bone marrow aspiration and renal biopsy were performed. She was diagnosed with plasma cell dyscrasia because a bone marrow aspiration specimen showed plasma cells at 6.1%. Renal tissues revealed the formation of nodular glomerulosclerosis which was negative for Congo-red staining. Renal immunohistochemistry showed positive staining for kappa light chains in the nodular lesions, proximal tubules and part of Bowman's capsules. Her renal involvement was diagnosed as light chain deposition disease. Proteinuria disappeared and renal function stabilized after high-dose chemotherapy and autologous stem cell transplantation. It appears that an early initiation of active therapy such as high-dose chemotherapy and autologous stem cell transplantation may be beneficial for patients with light chain deposition disease.
Emery, William J.; Castro, Sandra L.; Lindstrom, Eric (Technical Monitor)
The primary purpose of this project was to evaluate and improve models for the bulk-skin temperature difference to the point where they could accurately and reliably apply under a wide variety of environmental conditions. To accomplish this goal, work was conducted in three primary areas. These included production of an archive of available data sets containing measurements of the skin and bulk temperatures and associated environmental conditions, evaluation of existing skin layer models using the compiled data archive, and additional theoretical work on the development of an improved model using the data collected under diverse environmental conditions. In this work we set the basis for a new physical model of renewal type, and propose a parameterization for the temperature difference across the cool skin of the ocean in which the effects of thermal buoyancy, wind stress, and microscale breaking are all integrated by means of the appropriate renewal time scales. Ideally, we seek to obtain a model that will accurately apply under a wide variety of environmental conditions. A summary of the work in each of these areas is included in this report. A large amount of work was accomplished under the support of this grant. The grant supported the graduate studies of Sandra Castro and the preparation of her thesis which will be completed later this year. This work led to poster presentations at the 1999 American Geophysical Union Fall Meeting and 2000 IGARSS meeting. Additional work will be presented in a talk at this year's American Meteorological Society Air-Sea Interaction Meeting this May. The grant also supported Sandra Castro during a two week experiment aboard the R/P Flip (led by Dr. Andrew Jessup of the Applied Physics Laboratory) to help obtain additional shared data sets and to provide Sandra with a fundamental understanding of the physical processes needed in the models. In a related area, the funding also partially supported Dr. William Emery and Daniel
Full Text Available BACKGROUND: Obesity is associated with glomerular hyperfiltration, increased proximal tubular sodium reabsorption, glomerular enlargement and renal hypertrophy. A single experimental study reported an increased glomerular urinary space in obese dogs. Whether proximal tubular volume is increased in obese subjects and whether their glomerular and tubular urinary spaces are enlarged is unknown. OBJECTIVE: To determine whether proximal tubules and glomerular and tubular urinary space are enlarged in obese subjects with proteinuria and glomerular hyperfiltration. METHODS: Kidney biopsies from 11 non-diabetic obese with proteinuria and 14 non-diabetic lean patients with a creatinine clearance above 50 ml/min and with mild or no interstitial fibrosis were retrospectively analyzed using morphometric methods. The cross-sectional area of the proximal tubular epithelium and lumen, the volume of the glomerular tuft and of Bowman's space and the nuclei number per tubular profile were estimated. RESULTS: Creatinine clearance was higher in the obese than in the lean group (P=0.03. Proteinuria was similarly increased in both groups. Compared to the lean group, the obese group displayed a 104% higher glomerular tuft volume (P=0.001, a 94% higher Bowman's space volume (P=0.003, a 33% higher cross-sectional area of the proximal tubular epithelium (P=0.02 and a 54% higher cross-sectional area of the proximal tubular lumen (P=0.01. The nuclei number per proximal tubular profile was similar in both groups, suggesting that the increase in tubular volume is due to hypertrophy and not to hyperplasia. CONCLUSIONS: Obesity-related glomerular hyperfiltration is associated with proximal tubular epithelial hypertrophy and increased glomerular and tubular urinary space volume in subjects with proteinuria. The expanded glomerular and urinary space is probably a direct consequence of glomerular hyperfiltration. These effects may be involved in the pathogenesis of obesity
Gruszka, Damian; Janeczko, Anna; Dziurka, Michal; Pociecha, Ewa; Fodor, Jozsef
Drought is one of the most adverse stresses that affect plant growth and yield. Disturbances in metabolic activity resulting from drought cause overproduction of reactive oxygen species. It is postulated that brassinosteroids (BRs) regulate plant tolerance to the stress conditions, but the underlying mechanisms remain largely unknown. An involvement of endogenous BRs in regulation of the antioxidant homeostasis is not fully clarified either. Therefore, the aim of this study was to elucidate the role of endogenous BRs in regulation of non-enzymatic antioxidants in barley (Hordeum vulgare) under control and drought conditions. The plant material included the 'Bowman' cultivar and a group of semi-dwarf near-isogenic lines (NILs), representing mutants deficient in BR biosynthesis or signaling. In general, accumulations of 11 compounds representing various types of non-enzymatic antioxidants were analyzed under both conditions. The analyses of accumulations of reduced and oxidized forms of ascorbate indicated that the BR mutants contain significantly higher contents of dehydroascorbic acid under drought conditions when compared with the 'Bowman' cultivar. The analysis of glutathione accumulation indicated that under the control conditions the BR-insensitive NILs contained significantly lower concentrations of this antioxidant when compared with the rest of genotypes. Therefore, we postulate that BR sensitivity is required for normal accumulation of glutathione. A complete accumulation profile of various tocopherols indicated that functional BR biosynthesis and signaling are required for their normal accumulation under both conditions. Results of this study provided an insight into the role of endogenous BRs in regulation of the non-enzymatic antioxidant homeostasis. © 2017 Scandinavian Plant Physiology Society.
Full Text Available Vijaya Juturu,1 James P Bowman,2 Jayant Deshpande1 1Department of Scientific and Clinical Affairs, OmniActive Health Technologies Inc., Morristown, NJ, 2James P Bowman & Associates LLC, Loveland, OH, USA Purpose: Carotenoids, especially lutein and zeaxanthin isomers (L/Zi, filter blue light and protect skin from environmental factors including high-energy sources. These carotenoids may be able to block the formation of melanin pathways, decrease cytokines, and increase antioxidants.Subjects and methods: This is a randomized, double-blind, placebo-controlled clinical trial over a 12-week supplementation period. Fifty healthy people (50 healthy subjects were recruited and 46 subjects completed the study (males and females, age: 18–45 years with mild-to-moderate dry skin were included in this study. Skin type of the subjects was classified as Fitzpatrick skin type II–IV scale. Subjects were administered with either an oral dietary supplement containing 10 mg lutein (L and 2 mg zeaxanthin isomers (Zi (L/Zi: RR-zeaxanthin and RS (meso-zeaxanthin or a placebo daily for 12 weeks. The minimal erythemal dose and skin lightening (L* were measured via the Chromameter®. The individual typological angle was calculated. Subjective assessments were also recorded.Results: Overall skin tone was significantly improved in the L/Zi group compared to placebo (P<0.0237, and luminance (L* values were significantly increased in the L/Zi group. Mean minimal erythemal dose was increased with L/Zi supplementation after 12 weeks of supplementation. L/Zi supplementation significantly increased the individual typological angle.Conclusion: L/Zi supplementation lightens and improves skin conditions. Keywords: lutein, zeaxanthin isomers, skin lightening, minimal erythemal dose, individual typological angle, overall skin tone
Ziemkiewicz, Michael P; Roscioli, Joseph R; Nesbitt, David J
Jet cooled NO molecules are scattered at 45° with respect to the surface normal from a liquid gallium surface at E(inc) from 1.0(3) to 20(6) kcal/mol to probe rotationally and electronically inelastic scattering from a gas-molten metal interface (numbers in parenthesis represent 1σ uncertainty in the corresponding final digits). Scattered populations are detected at 45° by confocal laser induced fluorescence (LIF) on the γ(0-0) and γ(1-1) A(2)Σ ← X(2)Π(Ω) bands, yielding rotational, spin-orbit, and λ-doublet population distributions. Scattering of low speed NO molecules results in Boltzmann distributions with effective temperatures considerably lower than that of the surface, in respectable agreement with the Bowman-Gossage rotational cooling model [J. M. Bowman and J. L. Gossage, Chem. Phys. Lett. 96, 481 (1983)] for desorption from a restricted surface rotor state. Increasing collision energy results in a stronger increase in scattered NO rotational energy than spin-orbit excitation, with an opposite trend noted for changes in surface temperature. The difference between electronic and rotational dynamics is discussed in terms of the possible influence of electron hole pair excitations in the conducting metal. While such electronically non-adiabatic processes can also influence vibrational dynamics, the γ(1-1) band indicates rotational energy transfer is compared from a hard cube model perspective with previous studies of NO scattering from single crystal solid surfaces. Despite a lighter atomic mass (70 amu), the liquid Ga surface is found to promote translational to rotational excitation more efficiently than Ag(111) (108 amu) and nearly as effectively as Au(111) (197 amu). The enhanced propensity for Ga(l) to transform incident translational energy into rotation is discussed in terms of temperature-dependent capillary wave excitation of the gas-liquid metal interface. © 2011 American Institute of Physics
Danielle Nascimento Silva
Full Text Available The objective of this study was to describe the anatomic and histologic features of the Sapajus sp. eye, comparing similarities and differences of humans and other species of non-human primates for biomedical research purposes. Computed tomography (CT of adnexa, eye and orbit live animal, as well as formolized pieces of the same structures of Sapajus sp. for anatomical and histological study were also performed. The anatomical description of the eye and adnexa was performed using the techniques of topographic dissection and exenteration. Histological fragments were fixated in buffered formalin 10%, processed by the routine paraffin inclusion technique, stained with hematoxylin-eosin and special stains. CT scan evaluation showed no differences between the live animal and the formolized head on identification of visual apparatus structures. Anatomic and histologic evaluation revealed rounded orbit, absence of the supraorbital foramen and frontal notch, little exposure of the sclera, with slight pigmentation of the exposed area and marked pigmentation at the sclerocorneal junction. Masson's Trichrome revealed the Meibomian glands, the corneal epithelium and Bowman's membrane; in the choroid, melanocytes and Bruch's membrane were observed; and in the retina, cones and rods as well as, optic nerve, the lamina cribrosa of the nerve fibers bundles. Toluidine blue highlighted the membranes: Bowman, Descemet and the endothelium; in the choroid: melanocytes; and in the retina: nuclear layers and retinal pigment epithelium. In view of the observed results Sapajus sp. is an important experimental model for research in the ophthalmology field, which has been shown due to the high similarity of its anatomical and histological structures with the human species.
Frances E. Jones
Full Text Available Collagen IV is a major component of basement membranes, and mutations in COL4A1, which encodes collagen IV alpha chain 1, cause a multisystemic disease encompassing cerebrovascular, eye and kidney defects. However, COL4A1 renal disease remains poorly characterized and its pathomolecular mechanisms are unknown. We show that Col4a1 mutations in mice cause hypotension and renal disease, including proteinuria and defects in Bowman's capsule and the glomerular basement membrane, indicating a role for Col4a1 in glomerular filtration. Impaired sodium reabsorption in the loop of Henle and distal nephron despite elevated aldosterone levels indicates that tubular defects contribute to the hypotension, highlighting a novel role for the basement membrane in vascular homeostasis by modulation of the tubular response to aldosterone. Col4a1 mutations also cause diabetes insipidus, whereby the tubular defects lead to polyuria associated with medullary atrophy and a subsequent reduction in the ability to upregulate aquaporin 2 and concentrate urine. Moreover, haematuria, haemorrhage and vascular basement membrane defects confirm an important vascular component. Interestingly, although structural and compositional basement membrane defects occurred in the glomerulus and Bowman's capsule, no tubular basement membrane defects were detected. By contrast, medullary atrophy was associated with chronic ER stress, providing evidence for cell-type-dependent molecular mechanisms of Col4a1 mutations. These data show that both basement membrane defects and ER stress contribute to Col4a1 renal disease, which has important implications for the development of treatment strategies for collagenopathies.
Bowman, Barry J; Abreu, Stephen; Johl, Jessica K; Bowman, Emma Jean
The pmr gene is predicted to encode a Ca(2+)-ATPase in the secretory pathway. We examined two strains of Neurospora crassa that lacked PMR: the Δpmr strain, in which pmr was completely deleted, and pmr(RIP), in which the gene was extensively mutated. Both strains had identical, complex phenotypes. Compared to the wild type, these strains required high concentrations of calcium or manganese for optimal growth and had highly branched, slow-growing hyphae. They conidiated poorly, and the shape and size of the conidia were abnormal. Calcium accumulated in the Δpmr strains to only 20% of the wild-type level. High concentrations of MnCl(2) (1 to 5 mM) in growth medium partially suppressed the morphological defects but did not alter the defect in calcium accumulation. The Δpmr Δnca-2 double mutant (nca-2 encodes a Ca(2+)-ATPase in the plasma membrane) accumulated 8-fold more calcium than the wild type, and the morphology of the hyphae was more similar to that of wild-type hyphae. Previous experiments failed to show a function for nca-1, which encodes a SERCA-type Ca(2+)-ATPase in the endoplasmic reticulum (B. J. Bowman, S. Abreu, E. Margolles-Clark, M. Draskovic, and E. J. Bowman, Eukaryot. Cell 10:654-661, 2011). The pmr(RIP) Δnca-1 double mutant accumulated small amounts of calcium, like the Δpmr strain, but exhibited even more extreme morphological defects. Thus, PMR can apparently replace NCA-1 in the endoplasmic reticulum, but NCA-1 cannot replace PMR. The morphological defects in the Δpmr strain are likely caused, in part, by insufficient concentrations of calcium and manganese in the Golgi compartment; however, PMR is also needed to accumulate normal levels of calcium in the whole cell.
Manuel Cano Rodríguez
Full Text Available En los últimos años ha cobrado importancia el estudio de la "Paradoja de Bowman", es decir, la correlación negativa existente entre las medidas de rentabilidad y riesgo obtenidas a partir de las cifras contables. No obstante, la investigación se ha centrado más en analizar las causas de esta relación que en explicar cómo pueden coexistir dos tipos distintos de relación rentabilidad-riesgo: negativa para los indicadores contables y positiva para los indicadores de mercado. En este trabajo desarrollamos un modelo matemático que compatibiliza ambas relaciones. Las conclusiones obtenidas en el modelo señalan hacia una relación positiva entre las medidas obtenidas en el mercado de capitales y el riesgo medido con cifras contables, así como una relación negativa entre las primeras y la rentabilidad calculada contablemente.During the last few years, the importance of the research on Bowman's Paradox -the negative relationship between accounting measures of risk and return- has grown. Nevertheless, research has mostly been focused on studying the causes of the negative accounting relation, instead of explaining how, two different types of risk-return relationship can coexist: negative for the accounting indicators and positive for the market indicators. In this study, we develop a mathematical model, based on the Residual income Valuation Model for making both kinds of relations compatible. Our results show that there exists a positive relationship between the accounting measures of risk and the market measures of risk and return, but a negative influence of the accounting profitability on both market variables.
Najafian, Sohrab; Beigzadeh, Borhan; Riahi, Mohammad; Khadir Chamazkoti, Fatemeh; Pouramir, Mahdi
Analysis of glomeruli geometry is important in histopathological evaluation of renal microscopic images. Due to the shape and size disparity of even glomeruli of same kidney, automatic detection of these renal objects is not an easy task. Although manual measurements are time consuming and at times are not very accurate, it is commonly used in medical centers. In this paper, a new method based on Fourier transform following usage of some shape descriptors is proposed to detect these objects and their geometrical parameters. Reaching the goal, a database of 400 regions are selected randomly. 200 regions of which are part of glomeruli and the other 200 regions are not belong to renal corpuscles. ROC curve is used to decide which descriptor could classify two groups better. f_measure, which is a combination of both tpr (true positive rate) and fpr (false positive rate), is also proposed to select optimal threshold for descriptors. Combination of three parameters (solidity, eccentricity, and also mean squared error of fitted ellipse) provided better result in terms of f_measure to distinguish desired regions. Then, Fourier transform of outer edges is calculated to form a complete curve out of separated region(s). The generality of proposed model is verified by use of cross validation method, which resulted tpr of 94%, and fpr of 5%. Calculation of glomerulus' and Bowman's space with use of the algorithm are also compared with a non-automatic measurement done by a renal pathologist, and errors of 5.9%, 5.4%, and 6.26% are resulted in calculation of Capsule area, Bowman space, and glomeruli area, respectively. Having tested different glomeruli with various shapes, the experimental consequences show robustness and reliability of our method. Therefore, it could be used to illustrate renal diseases and glomerular disorders by measuring the morphological changes accurately and expeditiously. Copyright © 2017 Elsevier B.V. All rights reserved.
Ye, Youxin; Wang, Bingyin; Jiang, Xinxin; Hu, Weiming; Feng, Jian; Li, Hua; Jin, Mei; Ying, Yingjuan; Wang, Wenjuan; Mao, Xiaoou; Jin, Kunlin
Animal studies indicate that adult renal stem/progenitor cells can undergo rapid proliferation in response to renal injury, but whether the same is true in humans is largely unknown. To examine the profile of renal stem/progenitor cells responsible for acute tubular necrosis in human kidney, double and triple immunostaining was performed using proliferative marker and stem/progenitor protein markers on sections from 10 kidneys with acute tubular necrosis and 4 normal adult kidneys. The immunopositive cells were recorded using 2-photon confocal laser scanning microscopy. We found that dividing cells were present in the tubules of the cortex and medulla, as well as the glomerulus in normal human kidney. Proliferative cells in the parietal layer of Bowman capsule expressed CD133, and dividing cells in the tubules expressed immature cell protein markers paired box gene 2, vimentin, and nestin. After acute tubular necrosis, Ki67-positive cells in the cortex tubules significantly increased compared with normal adult kidney. These Ki67-positive cells expressed CD133 and paired box gene 2, but not the cell death marker, activated caspase-3. In addition, the number of dividing cells increased significantly in patients with acute tubular necrosis who subsequently recovered, compared with patients with acute tubular necrosis who consequently developed protracted acute tubular necrosis or died. Our data suggest that renal stem/progenitor cells may reside not only in the parietal layer of Bowman capsule but also in the cortex and medulla in normal human kidney, and the proliferative capacity of renal stem/progenitor cells after acute tubular necrosis may be an important determinant of a patient's outcome. Copyright © 2011 Elsevier Inc. All rights reserved.
Kaverina, Natalya V; Eng, Diana G; Schneider, Remington R S; Pippin, Jeffrey W; Shankland, Stuart J
The current studies used genetic fate mapping to prove that adult podocytes can be partially replenished following depletion. Inducible NPHS2-rtTA/tetO-Cre/RS-ZsGreen-R reporter mice were generated to permanently label podocytes with the ZsGreen reporter. Experimental focal segmental glomerulosclerosis (FSGS) was induced with a cytotoxic podocyte antibody. On FSGS day 7, immunostaining for the podocyte markers p57, synaptopodin, and podocin were markedly decreased by 44%, and this was accompanied by a decrease in ZsGreen fluorescence. The nuclear stain DAPI was absent in segments of reduced ZsGreen and podocyte marker staining, which is consistent with podocyte depletion. Staining for p57, synaptopodin, podocin, and DAPI increased at FSGS day 28 and was augmented by the ACE inhibitor enalapril, which is consistent with a partial replenishment of podocytes. In contrast, ZsGreen fluorescence did not return and remained significantly low at day 28, indicating replenishment was from a nonpodocyte origin. Despite administration of bromodeoxyuridine (BrdU) thrice weekly throughout the course of disease, BrdU staining was not detected in podocytes, which is consistent with an absence of proliferation. Although ZsGreen reporting was reduced in the tuft at FSGS day 28, labeled podocytes were detected along the Bowman's capsule in a subset of glomeruli, which is consistent with migration from the tuft. Moreover, more than half of the migrated podocytes coexpressed the parietal epithelial cell (PEC) proteins claudin-1, SSeCKS, and PAX8. These results show that although podocytes can be partially replenished following abrupt depletion, a process augmented by ACE inhibition, the source or sources are nonpodocyte in origin and are independent of proliferation. Furthermore, a subset of podocytes migrate to the Bowman's capsule and begin to coexpress PEC markers. Copyright © 2016 the American Physiological Society.
Mark A. Sippel; William C. Carrigan; Kenneth D. Luff; Lyn Canter
Integrated software has been written that comprises the tool kit for the Intelligent Computing System (ICS). The software tools in ICS have been developed for characterization of reservoir properties and evaluation of hydrocarbon potential using a combination of inter-disciplinary data sources such as geophysical, geologic and engineering variables. The ICS tools provide a means for logical and consistent reservoir characterization and oil reserve estimates. The tools can be broadly characterized as (1) clustering tools, (2) neural solvers, (3) multiple-linear regression, (4) entrapment-potential calculator and (5) file utility tools. ICS tools are extremely flexible in their approach and use, and applicable to most geologic settings. The tools are primarily designed to correlate relationships between seismic information and engineering and geologic data obtained from wells, and to convert or translate seismic information into engineering and geologic terms or units. It is also possible to apply ICS in a simple framework that may include reservoir characterization using only engineering, seismic, or geologic data in the analysis. ICS tools were developed and tested using geophysical, geologic and engineering data obtained from an exploitation and development project involving the Red River Formation in Bowman County, North Dakota and Harding County, South Dakota. Data obtained from 3D seismic surveys, and 2D seismic lines encompassing nine prospective field areas were used in the analysis. The geologic setting of the Red River Formation in Bowman and Harding counties is that of a shallow-shelf, carbonate system. Present-day depth of the Red River formation is approximately 8000 to 10,000 ft below ground surface. This report summarizes production results from well demonstration activity, results of reservoir characterization of the Red River Formation at demonstration sites, descriptions of ICS tools and strategies for their application.
Panzera, Francesco; Lombardo, Giuseppe; Rigano, Rosaria
The seismic hazard assessment (SHA) can be performed using either Deterministic or Probabilistic approaches. In present study a probabilistic analysis was carried out for the Catania and Siracusa towns using two different procedures: the 'site' (Albarello and Mucciarelli, 2002) and the 'seismotectonic' (Cornell 1968; Esteva, 1967) methodologies. The SASHA code (D'Amico and Albarello, 2007) was used to calculate seismic hazard through the 'site' approach, whereas the CRISIS2007 code (Ordaz et al., 2007) was adopted in the Esteva-Cornell procedure. According to current international conventions for PSHA (SSHAC, 1997), a logic tree approach was followed to consider and reduce the epistemic uncertainties, for both seismotectonic and site methods. The code SASHA handles the intensity data taking into account the macroseismic information of past earthquakes. CRISIS2007 code needs, as input elements, a seismic catalogue tested for completeness, a seismogenetic zonation and ground motion predicting equations. Data concerning the characterization of regional seismic sources and ground motion attenuation properties were taken from the literature. Special care was devoted to define source zone models, taking into account the most recent studies on regional seismotectonic features and, in particular, the possibility of considering the Malta escarpment as a potential source. The combined use of the above mentioned approaches allowed us to obtain useful elements to define the site seismic hazard in Catania and Siracusa. The results point out that the choice of the probabilistic model plays a fundamental role. It is indeed observed that when the site intensity data are used, the town of Catania shows hazard values higher than the ones found for Siracusa, for each considered return period. On the contrary, when the Esteva-Cornell method is used, Siracusa urban area shows higher hazard than Catania, for return periods greater than one hundred years. The higher hazard observed
The VITRO Score (Von Willebrand Factor Antigen/Thrombocyte Ratio as a New Marker for Clinically Significant Portal Hypertension in Comparison to Other Non-Invasive Parameters of Fibrosis Including ELF Test.
Full Text Available Clinically significant portal hypertension (CSPH, defined as hepatic venous pressure gradient (HVPG ≥10 mmHg, causes major complications. HVPG is not always available, so a non-invasive tool to diagnose CSPH would be useful. VWF-Ag can be used to diagnose. Using the VITRO score (the VWF-Ag/platelet ratio instead of VWF-Ag itself improves the diagnostic accuracy of detecting cirrhosis/ fibrosis in HCV patients.This study tested the diagnostic accuracy of VITRO score detecting CSPH compared to HVPG measurement.All patients underwent HVPG testing and were categorised as CSPH or no CSPH. The following patient data were determined: CPS, D'Amico stage, VITRO score, APRI and transient elastography (TE.The analysis included 236 patients; 170 (72% were male, and the median age was 57.9 (35.2-76.3; 95% CI. Disease aetiology included ALD (39.4%, HCV (23.4%, NASH (12.3%, other (8.1% and unknown (11.9%. The CPS showed 140 patients (59.3% with CPS A; 56 (23.7% with CPS B; and 18 (7.6% with CPS C. 136 patients (57.6% had compensated and 100 (42.4% had decompensated cirrhosis; 83.9% had HVPG ≥10 mmHg. The VWF-Ag and the VITRO score increased significantly with worsening HVPG categories (P<0.0001. ROC analysis was performed for the detection of CSPH and showed AUC values of 0.92 for TE, 0.86 for VITRO score, 0.79 for VWF-Ag, 0.68 for ELF and 0.62 for APRI.The VITRO score is an easy way to diagnose CSPH independently of CPS in routine clinical work and may improve the management of patients with cirrhosis.
Lane, C.; D'Amico, E.; Wing, O.; Bates, P. D.
Wetlands interact with other waters across a variable connectivity continuum, from permanent to transient, from fast to slow, and from primarily surface water to exclusively groundwater flows. Floodplain wetlands typically experience fast and frequent surface and near-surface groundwater interactions with their river networks, leading to an increasing effort to tailor management strategies for these wetlands. Management of floodplain wetlands is contingent on accurate floodplain delineation, and though this has proven challenging, multiple efforts are being made to alleviate this data gap at the conterminous scale using spatial, physical, and hydrological floodplain proxies. In this study, we derived and contrasted floodplain extents using the following nationally available approaches: 1) a geospatial-buffer floodplain proxy (Lane and D'Amico 2016, JAWRA 52(3):705-722, 2) a regionalized flood frequency analysis coupled to a 30m resolution continental-scale hydraulic model (RFFA; Smith et al. 2015, WRR 51:539-553), and 3) a soils-based floodplain analysis (Sangwan and Merwade 2015, JAWRA 51(5):1286-1304). The geospatial approach uses National Wetlands Inventory and buffered National Hydrography Datasets. RFFA estimates extreme flows based on catchment size, regional climatology and upstream annual rainfall and routes these flows through a hydraulic model built with data from USGS HydroSHEDS, NOAA, and the National Elevation Dataset. Soil-based analyses define floodplains based on attributes within the USDA soil-survey data (SSURGO). Nearly 30% (by count) of U.S. freshwater wetlands are located within floodplains with geospatial analyses, contrasted with 37% (soils-based), and 53% (RFFA-based). The dichotomies between approaches are mainly a function of input data-layer resolution, accuracy, coverage, and extent, further discussed in this presentation. Ultimately, these spatial analyses and findings will improve floodplain and integrated wetland system extent
Papantoniou, Kyriaki; Castaño-Vinyals, Gemma; Espinosa, Ana; Aragonés, Nuria; Pérez-Gómez, Beatriz; Burgos, Javier; Gómez-Acebo, Inés; Llorca, Javier; Peiró, Rosana; Jimenez-Moleón, Jose Juan; Arredondo, Francisco; Tardón, Adonina; Pollan, Marina; Kogevinas, Manolis
Night shift work has been classified as a probable human carcinogen based on experimental studies and limited human evidence on breast cancer. Evidence on other common cancers, such as prostate cancer, is scarce. Chronotype is an individual characteristic that may relate to night work adaptation. We evaluated night shift work with relation to prostate cancer, taking into account chronotype and disease severity in a population based case-control study in Spain. We included 1,095 prostate cancer cases and 1,388 randomly selected population controls. We collected detailed information on shift schedules (permanent vs. rotating, time schedules, duration, frequency), using lifetime occupational history. Sociodemographic and lifestyle factors were assessed by face-to-face interviews and chronotype through a validated questionnaire. We used unconditional logistic regression analysis adjusting for potential confounders. Subjects who had worked at least for one year in night shift work had a slightly higher prostate cancer risk [Odds Ratio (OR) 1.14; 95%CI 0.94, 1.37] compared with never night workers; this risk increased with longer duration of exposure (≥ 28 years: OR 1.37; 95%CI 1.05, 1.81; p-trend = 0.047). Risks were more pronounced for high risk tumors [D'Amico classification, Relative Risk Ratio (RRR) 1.40; 95%CI 1.05, 1.86], particularly among subjects with longer duration of exposure (≥28 years: RRR 1.63; 95%CI 1.08, 2.45; p-trend = 0.027). Overall risk was higher among subjects with an evening chronotype, but also increased in morning chronotypes after long-term night work. In this large population based study, we found an association between night shift work and prostate cancer particularly for tumors with worse prognosis. © 2014 UICC.
Katia Barão Corgozinho
Full Text Available ABSTRACT. Corgozinho K.B., Cunha S.C.S., Neves A.P., Belchior C., Damico C.B., Silva C.A., Souza H.J.M.& Ferreira A.M.R. [Ionized calcium serum evaluation in unilateral thyroidectomized cats.] Avaliação do cálcio ionizado em gatos submetidos a tireoidectomia unilateral. Revista Brasileira de Medicina Veterinária 37(4:345-349, 2015. Pós-Graduação em Clínica e Reprodução Animal, Faculdade de Veterinária, Universidade Federal Fluminense, Rua Vital Brasil Filho, 64, Niterói, RJ 24230-340, Brasil. E-mail: firstname.lastname@example.org Seventeen hyperthyroid cats with cervical palpable nodules were submitted to clinical and laboratorial examination and they were prepared to surgery. Unilateral thyroparathyroidectomy with parathyroid gland autotransplantation was performed. Concentrations of serum urea, creatinine, alkaline phosphatase, alanine aminotransferase, phosphorus, potassium, total thyroxine and hematologic profile were determined before and seven days after surgery. Blood samples for serum ionized calcium concentration were collected before and after surgery on days 1, 2, 7, 15, 21. All cats had ionized calcium concentration within the reference range before surgery. Serum calcium concentration fell significantly in all cats within 24 hours after surgery. Hypocalcemia occurred in two cats without clinical signs. Ionized calcium concentration decreased after surgery and returned to normal levels on day 7 postoperatively. The results of this study suggest that calcium concentration must be measured before surgery in cats submitted to thyroidectomy even if they are submitted to unilateral technique.
Sylvester, John E.; Grimm, Peter D.; Wong, Jason; Galbreath, Robert W.; Merrick, Gregory; Blasko, John C.
Purpose: To report 15-year biochemical relapse-free survival (BRFS), cause-specific survival (CSS), and overall survival (OS) outcomes of patients treated with I 125 brachytherapy monotherapy for clinically localized prostate cancer early in the Seattle experience. Methods and Materials: Two hundred fifteen patients with clinically localized prostate cancer were consecutively treated from 1988 to 1992 with I 125 monotherapy. They were prospectively followed as a tight cohort. They were evaluated for BRFS, CSS, and OS. Multivariate analysis was used to evaluate outcomes by pretreatment clinical prognostic factors. BRFS was analyzed by the Phoenix (nadir + 2 ng/mL) definition. CSS and OS were evaluated by chart review, death certificates, and referring physician follow-up notes. Gleason scoring was performed by general pathologists at a community hospital in Seattle. Time to biochemical failure (BF) was calculated and compared by Kaplan-Meier plots. Results: Fifteen-year BRFS for the entire cohort was 80.4%. BRFS by D'Amico risk group classification cohort analysis was 85.9%, 79.9%, and 62.2% for low, intermediate, and high-risk patients, respectively. Follow-up ranged from 3.6 to 18.4 years; median follow-up was 15.4 years for biochemically free of disease patients. Overall median follow-up was 11.7 years. The median time to BF in those who failed was 5.1 years. CSS was 84%. OS was 37.1%. Average age at time of treatment was 70 years. There was no significant difference in BRFS between low and intermediate risk groups. Conclusion: I 125 monotherapy results in excellent 15-year BRFS and CSS, especially when taking into account the era of treatment effect.
Roberts, Robin; Mitchell, Corydon; Tancawan, Ana Lourdes; Pedican, Mandi; Jones, Glenn Wayne
Grand Bahama (pop. 51,000) is an island within the Bahamas archipelago. A local chapter of International Us TOO Prostate Cancer Support Group (UTGB) has led an annual community-based prostate cancer screening clinic in Grand Bahama each September since 2009. Features of this initiative, characteristics of attendees, and a description of found cancers were summarized to determine the clinic's value and to guide improvements. We analyzed the established clinic from 2012 to 2015, wherein UTGB attracted corporate funding, volunteers managed clinics, and health professionals provided healthcare services. An explicit algorithm was used to sort clients by age, comorbidities, and findings from digital rectal examinations, and prostate-specific antigen (PSA) values, to determine which clients would undergo secondary assessment and prostate biopsy. Overall, 1,844 males were registered (mean age 57.6 years), and only 149 men attended on more than one occasion for a total of 1,993 clinic visit. The urologist reviewed 315 men in secondary follow-up, for elevated PSA and/or an abnormal digital rectal examination. Of these, 45 men fulfilled criteria for trans-rectal ultrasound biopsy, and there were 40 found cases of prostate cancer, for a positive-predictive value of 89%. By D'Amico risk-stratification, these 40 cases were low (10%), intermediate (40%), and high risk (50%). The urologist counseled all 40 cases and facilitated access to standard care. This study suggests that low-resource countries can advance cost-effective screening clinics, apply policy guidelines, and provide services within acceptable standards of care. It is the expectation, with a sustained effort and community participation over the ensuing years, that earlier disease presentation will occur and, consequently, a concomitant decrease in the disease-specific mortality.
Abdel Raheem, Ali; Kim, Dae Keun; Santok, Glen Denmer; Alabdulaali, Ibrahim; Chung, Byung Ha; Choi, Young Deuk; Rha, Koon Ho
To report the 5-year oncological outcomes of robot-assisted radical prostatectomy from the largest series ever reported from Asia. A retrospective analysis of 800 Asian patients who were treated with robot-assisted radical prostatectomy from July 2005 to May 2010 in the Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea was carried out. The primary end-point was to evaluate the biochemical recurrence. The secondary end-point was to show the biochemical recurrence-free survival, metastasis-free survival and cancer-specific survival. A total of 197 (24.65%), 218 (27.3%), and 385 (48.1%) patients were classified as low-, intermediate- and high-risk patients according to the D'Amico risk stratification risk criteria, respectively. The median follow-up period was 64 months (interquartile range 28-71 months). The overall incidence of positive surgical margin was 36.6%. There was biochemical recurrence in 183 patients (22.9%), 38 patients (4.8%) developed distant metastasis and 24 patients (3%) died from prostate cancer. Actuarial biochemical recurrence-free survival, metastasis-free survival, and cancer-specific survival rates at 5 years were 76.4%, 94.6% and 96.7%, respectively. Positive lymph node was associated with lower 5-year biochemical recurrence-free survival (9.1%), cancer-specific survival (75.7%) and metastasis-free survival (61.9%) rates (P < 0.001). On multivariable analysis, among all the predictors, positive lymph node was the strongest predictor of biochemical recurrence, cancer-specific survival and metastasis-free survival (P < 0.001). Herein we report the largest robot-assisted radical prostatectomy series from Asia. Robot-assisted radical prostatectomy is confirmed to be an oncologically safe procedure that is able to provide effective 5-year cancer control, even in patients with high-risk disease. © 2016 The Japanese Urological Association.
Ginsburg, Kevin B; Elshafei, Ahmed; Yu, Changhong; Jones, J Stephen; Cher, Michael L
To investigate the ability of salvage cryoablation of the prostate (SCAP) to delay the need for androgen deprivation therapy (ADT) in local recurrence after radiation therapy to the prostate using the Cryo-On-Line Database (COLD) registry. The COLD registry is comprised of a combination of retrospectively and prospectively collected data on patients undergoing primary and SCAP. Patients with local recurrence after radiation therapy were identified. Kaplan-Meier analysis was used to calculate ADT-free survival. We identified 898 patients that have undergone SCAP in the COLD registry. Overall, the calculated 5-year ADT-free survival probability was 0.713. When stratified by D'Amico risk group, 264 high-risk patients (71.9%), 234 intermediate-risk (86.7%),and 228 low-risk (87.7%) were free of ADT post-SCAP. This correlates with a 5-year ADT-free survival of 60.7, 73.9, and 82.4%, respectively. Patients with post-SCAP PSA nadir of <0.2 ng/mL had a 5 year ADT-free survival of 87.1% compared to 48.7% with a PSA nadir ≥0.2 ng/mL. Pre-operative ADT use or full versus partial gland SCAP did not have an effect on ADT use post-operatively. In 118 (55.4%) of patients with post-operative biochemical recurrence, ADT was not used. For patients with local recurrence after radiation, SCAP is an option that provides a high chance of avoiding or delaying ADT. The potential to delay ADT and its associated side effects should be a part of counseling sessions with the patient when discussing treatment options for locally recurrent prostate cancer after radiation. Avoidance of ADT is more clinically relevant than PSA elevation. © 2017 Wiley Periodicals, Inc.
Fujizuka, Yuji; Ito, Kazuto; Oki, Ryo; Suzuki, Rie; Sekine, Yoshitaka; Koike, Hidekazu; Matsui, Hiroshi; Shibata, Yasuhiro; Suzuki, Kazuhiro
To investigate the predictive value of various molecular forms of prostate-specific antigen in men with baseline prostate-specific antigen baseline prostate-specific antigen level baseline prostate-specific antigen- and age-adjusted men who did not develop prostate cancer. Serum prostate-specific antigen, free prostate-specific antigen, and [-2] proenzyme prostate-specific antigen were measured at baseline and last screening visit. The predictive impact of baseline prostate-specific antigen- and [-2] proenzyme prostate-specific antigen-related indices on developing prostate cancer was investigated. The predictive impact of those indices at last screening visit and velocities from baseline to final screening on tumor aggressiveness were also investigated. The baseline free to total prostate-specific antigen ratio was a significant predictor of prostate cancer development. The odds ratio was 6.08 in the lowest quintile baseline free to total prostate-specific antigen ratio subgroup. No serum indices at diagnosis were associated with tumor aggressiveness. The Prostate Health Index velocity and [-2] proenzyme prostate-specific antigen/free prostate-specific antigen velocity significantly increased in patients with higher risk D'Amico risk groups and higher Gleason scores. Free to total prostate-specific antigen ratio in men with low baseline prostate-specific antigen levels seems to predict the risk of developing prostate cancer, and it could be useful for a more effective individualized screening system. Longitudinal changes in [-2] proenzyme prostate-specific antigen-related indices seem to correlate with tumor aggressiveness, and they could be used as prognostic tool before treatment and during active surveillance. © 2017 The Japanese Urological Association.
Somford, D M; Hamoen, E H; Fütterer, J J; van Basten, J P; Hulsbergen-van de Kaa, C A; Vreuls, W; van Oort, I M; Vergunst, H; Kiemeney, L A; Barentsz, J O; Witjes, J A
We determined the positive and negative predictive values of multiparametric magnetic resonance imaging for extraprostatic extension at radical prostatectomy for different prostate cancer risk groups. We evaluated a cohort of 183 patients who underwent 3 Tesla multiparametric magnetic resonance imaging, including T2-weighted, diffusion weighted magnetic resonance imaging and dynamic contrast enhanced sequences, with an endorectal coil before radical prostatectomy. Pathological stage at radical prostatectomy was used as standard reference for extraprostatic extension. The cohort was classified into low, intermediate and high risk groups according to the D'Amico criteria. We recorded prevalence of extraprostatic extension at radical prostatectomy and determined sensitivity, specificity, positive predictive value and negative predictive value of multiparametric magnetic resonance imaging for extraprostatic extension in each group. Univariate and multivariate analyses were performed to identify predictors of extraprostatic extension at radical prostatectomy. The overall prevalence of extraprostatic extension at radical prostatectomy was 49.7% ranging from 24.7% to 77.1% between low and high risk categories. Overall staging accuracy of multiparametric magnetic resonance imaging for extraprostatic extension was 73.8%, with sensitivity, specificity, positive predictive value and negative predictive value of 58.2%, 89.1%, 84.1% and 68.3%, respectively. Positive predictive value of multiparametric magnetic resonance imaging for extraprostatic extension was best in the high risk cohort with 88.8%. Negative predictive value was highest in the low risk cohort with 87.7%. With an odds ratio of 10.3 multiparametric magnetic resonance imaging is by far the best preoperative predictor of extraprostatic extension at radical prostatectomy. For adequate patient counseling, knowledge of predictive values of multiparametric magnetic resonance imaging for extraprostatic extension is
Abern, Michael R; Aronson, William J; Terris, Martha K; Kane, Christopher J; Presti, Joseph C; Amling, Christopher L; Freedland, Stephen J
Active surveillance (AS) is increasingly accepted as appropriate management for low-risk prostate cancer (PC) patients. It is unknown whether delaying radical prostatectomy (RP) is associated with increased risk of biochemical recurrence (BCR) for men with intermediate-risk PC. We performed a retrospective analysis of 1,561 low and intermediate-risk men from the Shared Equal Access Regional Cancer Hospital (SEARCH) database treated with RP between 1988 and 2011. Patients were stratified by interval between diagnosis and RP (≤ 3, 3-6, 6-9, or >9 months) and by risk using the D'Amico classification. Cox proportional hazard models were used to analyze BCR. Logistic regression was used to analyze positive surgical margins (PSM), extracapsular extension (ECE), and pathologic upgrading. Overall, 813 (52%) men were low-risk, and 748 (48%) intermediate-risk. Median follow-up among men without recurrence was 52.9 months, during which 437 men (38.9%) recurred. For low-risk men, RP delays were unrelated to BCR, ECE, PSM, or upgrading (all P > 0.05). For intermediate-risk men, however, delays >9 months were significantly related to BCR (HR: 2.10, P = 0.01) and PSM (OR: 4.08, P 9 months were associated with BCR in subsets of intermediate-risk men with biopsy Gleason score ≤ 3 + 4 (HR: 2.51, P 9 months predicted greater BCR and PSM risk. If confirmed in future studies, this suggests delayed RP for intermediate-risk PC may compromise outcomes. Copyright © 2012 Wiley Periodicals, Inc.
edited by Ilaria Moschini
Full Text Available The language section of LEA - edited by Ilaria Moschini - is dedicated to the Critical Multimodal Analysis of Digital Discourse, an approach that encompasses the linguistic and semiotic detailed investigation of texts within a socio-cultural perspective. It features an interview with Professor Theo van Leeuwen by Ilaria Moschini and four essays: “Retwitting, reposting, repinning; reshaping identities online: Towards a social semiotic multimodal analysis of digital remediation” by Elisabetta Adami; “Multimodal aspects of corporate social responsibility communication” by Carmen Daniela Maier; “Pervasive Technologies and the Paradoxes of Multimodal Digital Communication” by Sandra Petroni and “Can the powerless speak? Linguistic and multimodal corporate media manipulation in digital environments: the case of Malala Yousafzai” by Maria Grazia Sindoni.
Sanfeliu, J.M.; Doumanian, J.E.
Gas Natural BAN, as a distribution gas company since 1993 in the north and west area of Buenos Aires Argentina, with 1,000,000 customers, had to develop a gas demand forecast system which should comply with the following basic requirements: Be able to do reliable forecasts with short historical information (2 years); Distinguish demands in areas of different characteristics, i.e. mainly residential, mainly industrial; Self-learning capability. To accomplish above goals, Gas Natural BAN chose in view of its own necessities, an artificial intelligence application (neural networks). 'SANDRA', the gas demand forecast system for gas distribution used by Gas Natural BAN, has the following features: Daily gas demand forecast, Hourly gas demand forecast and Breakdown of both forecast for each of the 3 basic zones in which the distribution area of Gas Natural BAN is divided. (au)
Vanda Fortuna Serafim
Full Text Available Como inventariar as crenças afro-brasileiras? Como captar a diferença por meio da fotografia? Como construir uma imagem dos deuses? Essas são algumas das questões que norteiam a reflexão aqui apresentada. Visando contribuir ao estudo das relações entre o patrimônio imaterial e as religiões e religiosidades, buscamos compreender como Pierre Verger, em meados do século XX, na Bahia, buscou enunciar as divindades africanas por meio da fotografia. A fonte histórica utilizada consiste na obra Notas sobre o culto aos orixás e voduns e os aportes teóricos e metodológicos são Sandra Pesavento e François Hartog.
Full Text Available Interested in academic standards and assessments proven to raise student achievement? You won’t get that from the Common Core Standards and their associated consortium tests, PARCC and SBAC. Despite the boisterous hype of higher, deeper, richer, more rigorous, and so on, there exists no valid evidence to support their claims of higher quality, achievement, or college readiness. There is a set of state standards and assessments, however, proven through actual experience to have raised academic achievement for students at all levels and in all curricular pathways: those used in Massachusetts from 2000 to 2011. So, why not use them? Such a proposal was recently proposed, and passed, by the Michigan Senate Education Policy Committee. Here, we provide links to Sandra Stotsky’s testimony before that committee, along with other relevant links. - See more at: http://nonpartisaneducation.org/Review/Resources/MichiganBill.htm
Epner, Luule, 1953-
Andrus Kivirähki "Rehepapp" (lav. Priit Pedajas), Liisu Krassi/ Sandra Sillaotsa "Sõbrapäev" (juh. Enn Keerd), August Kitzbergi "Kauka jumal" (lav. Andres Noormets), Silvi Väljali/Kiti Põllu "Jussikese seitse sõpra" (lav. Piret Rauk), A. H. Tammsaare /Urmas Lennuki "Vargamäe kuningriik" (lav. Jaanus Rohumaa), Jim Ashilevi "Nagu poisid vihma käes" (lav. Andres Noormets), Jaan Kruusvalli "Võikõllane üü" (lav. Enn Keerd), Friedebert Tuglase/Tiit Palu "Väike Illimar" (lav. Tiit Palu), Asrtid Reinla "Koduabiline" (lav. Tiit Palu), Jaan Kaplinski "Liblikas ja peegel" (lav. Madis Kalmet), Eva Koffi "Sabaga täht" (lav. Andres Noormets). Kasut. kirjandus lk. 39
Ramiro Alejandro Duarte
Full Text Available El siguiente trabajo es una reseña crítica del libro Matar a pobres corazones. Fronteras discursivas de la crónica policial, reflexiones sobre el caso de Sandra Cabrera en la prensa gráfica (Redactum, 2014, de Juan Pablo Robledo, comunicador y ensayista egresado de la Universidad Nacional de Rosario, en el que se reflexiona sobre las noticias del crimen atravesadas por múltiples factores tanto en su producción como en su circulación. Es un intento de pensar a partir de ellas, focalizadas en la práctica profesional, donde se abren más interrogantes que respuestas al fenómeno, cuyo análisis se escapa de los parámetros tradicionales de las empresas informacionales para construir un trabajo con argumentos concretos y delimitados.
Vuletić Georgije M.
Full Text Available Main goal of the research was to explore the relationship between motivation for motherhood and some of the sociodemographic variables which have been noticed as significant in the similar researches of other authors, as well as relation to the gender roles and gender identity, according to the model proposed by Sandra Bem. The study was conducted on the sample consisting of 571 female students in Belgrade. Statistically significant correlations are confirmed between motivation for motherhood and number of siblings, age of subject's mother and age of subject's mother at first birth. The highest correlation is found between motivation for motherhood and femininity. It is also proposed a preliminary questioner, as the first step of constructing an adequate instrument for measuring motivation for motherhood. The questioner is used for estimation of motivation for motherhood in this research.
prs. lli e er 21 A=S(I,1)/N, B=S(I,2)/N, C=S(I,3)/N, D=S(I,4)/N and, Mean = A + S(I,3) Standard Deviation = /B - A*A Veta I = (C - 3BA + 2A3...Aerospace Medical Research Laboratory (AMRL), Wright-Patterson Air Force Base. The authors wish to extend their thanks to C. E . Clauser, Sandra...W (-> u ɛ CO CT> a X! 0 +J rH C -H (U A! -P M-l • C 0 — •H CO CO u * a; x: QJ 0-.+J .p (0 C 0) — cu E +> TH 6
Full Text Available The economic crisis of 2008/2009 first emerged in the developed economies in 2008 and spilled over into developing countries and economies in transition through international financial and trade channels. This is the greatest financial crisis the world has faced since the Great Depression (Hanfstaengl, 2010; Sandra, 2008. At the height of the recession many feared that it would change into a depression. Banks were “unwilling to lend, credit spreads had widened sharply, stock markets had plunged and economies everywhere were stumbling” (Bustillo & Velloso, 2009:7. Some of the immediate effects of the economic recession on society included higher food prices and other living costs. Furthermore, corporations experienced reductions in their profit margins. It could reasonably be assumed that the NGO sector would suffer significantly as corporate donors and philanthropists typically contribute less during economic downturns.
Full Text Available Oktobra 2010 je pri Znanstveni založbi Filozofske fakultete Univerze v Ljublja ni izšel Slovensko – bolgarski in bolgarsko – slovenski priročnik, ki ga je uredil Ljudmil Dimitrov, lektor bolgarskega jezika na oddelku za slavistiko FF v letih 2005-2010. Pri pripravi gesel pa je sodelovala skupina nadarjenih študentov bolgarskega jezika: Ivana Angelova, Ana Drk, Lovro Kozamernik, Sandra Oman in Jaro Samobor. Knjiga je v grobem razdeljena na dva dela. Z ene strani je slovenskobolgarski del, z druge pa bolgarskoslovenski. Vsak posamezni del se dalje deli na enajst večjih poglavij/sklopov, ki se dalje delijo na podpoglavja oz. posamezne sklope. V njih je zajeta kratka predstavitev slovenskega oz. bolgarskega jezika, splošne besede, komunikacije, pa vse do kulture razvedrila, turističnih izrazov in izobraževanja.
Susana Sánchez Renieblas
Full Text Available Matthew Weiner´s successful American TV series, Mad Men (2007, set in the 1960s in New York, unmasks the private and the public spaces of the home and the office. In these spaces, not only do the masculine protagonists interact, but also several feminine characters do as well. The three female characters (Betty, Peggy and Joan, who will be analyzed, represent the female stereotypes of this period: the idyllic housewife, the Sandra Dee prototype and the bombshell Marilyn Monroe archetype. In comparing the private and public spaces of the home and the office, these women´s sexuality and submission will be affected and influenced by the spaces they inhabit.
at CERN's Globe of Science and Innovation Directed by Sandra Schüddekopf, with Anita Zieher For over 20 years, CERN has made an effort to attract more women to scientific careers and enhance the gender balance of its workforce. In addition to structural measures, these efforts range from outreach activities for schoolgirls to participation in high-level panel discussions on the topic. Today, the CERN Diversity Office, in cooperation with the Education, Communication and Outreach group, is happy to announce a play celebrating the achievements of three exceptional women in the field of science and technology: double Nobel Prize laureate Marie Curie (1867-1934), who discovered radioactivity, Austrian-Swedish nuclear physicist Lise Meitner (1878-1968), and Viennese Hollywood actress Hedy Lamarr (1914-2000), the inventor of frequency hopping. The play &quo...
Sandra Harding's newest book, Sciences from Below: Feminisms, Postcolonialities, and Modernities, continues her work in feminist standpoint theory and science and technologies studies, asking how we might judge "good" science. Attentive to race, class, gender, and imperialism, Harding critically examines Northern and Southern sciences and technologies by adopting the perspective of those who see from below. This vision from the peripheries lets Harding question stories of modern scientific progress, revealing a multiplicity of "ethnosciences" and critiquing modernity itself. However, while Harding aims to produce knowledge for the North's others by emphasizing woman's experience, she fails to question the category "woman," ignoring contemporary transgender and queer scholarship. Further, it is Harding's care for the North's subjugated others that motivates her writing, revealing that the struggle to achieve the standpoint "from below" so critical to her project is fueled by what her ally Maria Puig de la Bellacasa would term not thinking from, but thinking with, or, more precisely, "thinking with care."
Full Text Available While many philosophers speak of ‘pluralism’ within philosophy of biology, there has been little said about what such pluralism amounts to or what its underlying assumptions are. This has provoked so me anxiety about whether pluralism is compatible with their commitment to naturalism (Cussins 1992. This paper surveys three prominent pluralist positions (Sandra Mitchell and Michael Dietrich’s (2006 ‘integrative pluralism’, and both Peter Godfrey-Smith’s (1993 and Beth Preston’s (1998 pluralist analyses of functional explanations in evolutionary biology and demonstrates how all three are committed to a form of pragmatism. This analysis both clarifies the justification and grounding of pluralism and allows these pluralisms to avoid the criticisms of Cussins. I close by making some more general points about pluralism and its relationship to history and integration.
Full Text Available Le célèbre essai de Carol Gilligan paraît aujourd’hui dans une traduction revue et sous son titre original, redonnant toute sa place à la voix . Publié en 1982 aux États-Unis et disponible en français dès 1986 sous le titre Une si grande différence , les enjeux qui accompagnent cette nouvelle édition sont explicités dans la présentation , sous les plumes de Sandra Laugier et de Patricia Paperman. L’occasion de revenir sur les arguments centraux de cet essai et sur son ...
Whenever there is a competition, there are obviously participants – and especially winners! The awards ceremony for the competition to find a new name for the CERN Staff Association's Crèche and School took place on 15 May. During the ceremony, jointly led by Céline Grobon (President of the Crèche and School Steering Committee), Carole Dargagnon (Headmistress of the Crèche and School) and Jean-Baptiste Zenner (Staff Association delegate), the proposals selected by the jury were rewarded. The first place went to Marie-Luz Cavagna for her proposal "Le jardin des petits chercheurs", and the second place to Sarah Palluel for her proposal "Le Jardin des Zélectrons". Finally, Aude Mourey and Sandra Fleury tied for third place with their respective proposals "Les petits atomes" and "La crèche des particules". Can we find the winning name of the competition among...
Gabriel Pugliese Cardoso
Full Text Available This article discusses some of the principles that guide the descriptive forms of the actor-network theory (ANT of Bruno Latour and feminist standpoint theory formulated by Sandra Harding and Evelyn Fox Keller, through my research on the "Marie Curie Case". As a singular case between gender and science, the goal of thispaper is to play with ANT certainties against feminist perspective uncertainties. In the other hand, the certainties of feminist perspective are put against the uncertainties of ANT. With this counterpoint we intend to promote a reaction - in the chemical sense of the word – to the descriptive forms of the actor-network theory and feminist perspective taking away the obviousness of some of their assumptions. Doing that, we explore the moves of those reactions and their effects to the description which we do about science.
Full Text Available Este ensayo presenta personajes nómades, huérfanos, habitantes de la noche, sin hogar y sin ley. Estos personajes nos permiten analizar las relaciones entre violencia y lugar, en la cultura argentina durante los noventa y el inicio del 2000. Las películas elegidas son Un día de suerte (2002 de Sandra Gugliotta, Vagón Fumador (2001 de Verónica Chen y Hoy y Mañana (2003 de Alejandro Chomski. Las tres películas, filmadas a principios del 2000, tienen como escenario la ciudad de Buenos Aires, las historias siguen los desplazamientos de los jóvenes protagonistas por la ciudad, estableciendo nuevas fronteras entre el centro y la periferia, y la noción de no-lugar en la cartografía de la ciudad de Buenos Aires.This essay introduces nomadic characters, orphans, night crawlers, jobless and lawless people. These characters will allow us to analyze the bonds between violence and site in Argentine culture during the nineties and at the beginning of our century. The chosen films are Un día de suerte (A Lucky Day, 2002 by Sandra Gugliotta, Vagón Fumador (Smoking Car, 2001 by Verónica Chen, and Hoy y Mañana ( Today and Tomorrow, 2003 by Alejandro Chomski. These three movies, filmed at the beginning of the year 2000, are set in the city of Buenos Aires; the stories follow the wanderings of their young protagonists, showing new displacements between center and periphery in Buenos Aires' cartography.
Mani, Devendra; Schwan, Raffael; Fischer, Theo; Dey, Arghya; Kaufmann, Matin; Redlich, Britta; van der Meer, Lex; Schwaab, Gerhard; Havenith, Martina
Acid dissociation reactions are at the heart of chemistry. These reactions are well understood at the macroscopic level. However, a microscopic level understanding is still in the early stages of development. Questions such as 'how many H_2O molecules are needed to dissociate one HCl molecule?' have been posed and explored both theoretically and experimentally.1-5 Most of the theoretical calculations predict that four H_2O molecules are sufficient to dissociate one HCl molecule, resulting in the formation of a solvent separated H_3O+(H_2O)3Cl- cluster.1-3 IR spectroscopy in helium nanodroplets has earlier been used to study this dissociation process.3-5 However, these studies were carried out in the region of O-H and H-Cl stretch, which is dominated by the spectral features of undissociated (HCl)m-(H_2O)n clusters. This contributed to the ambiguity in assigning the spectral features arising from the dissociated cluster.4,5 Recent predictions from Bowman's group, suggest the presence of a broad spectral feature (1300-1360 wn) for the H_3O+(H_2O)3Cl- cluster, corresponding to the umbrella motion of H_3O+ moiety.6 This region is expected to be free from the spectral features due to the undissociated clusters. In conjunction with the FELIX laboratory, we have performed experiments on the (HCl)m(H_2O)n (m=1-2, n≥4) clusters, aggregated in helium nanodroplets, in the 900-1700 wn region. Mass selective measurements on these clusters revealed the presence of a weak-broad feature which spans between 1000-1450 wn and depends on both HCl as well as H_2O concentration. Measurements are in progress for the different deuterated species. The details will be presented in the talk. References: 1) C.T. Lee et al., J. Chem. Phys., 104, 7081 (1996). 2) H. Forbert et al., J. Am. Chem. Soc., 133, 4062 (2011). 3) A. Gutberlet et al., Science, 324, 1545 (2009). 4) S. D. Flynn et al., J. Phys. Chem. Lett., 1, 2233 (2010). 5) M. Letzner et al., J. Chem. Phys., 139, 154304 (2013). 6) J. M
Zubkova, M.; Boschetti, L.; Abatzoglou, J. T.
Studies have primarily attributed the recent decrease in global fire activity in many savanna and grassland regions as detected by the Global Fire Emission Database (GFEDv4s) to anthropogenic changes such as deforestation and cropland expansion (Andela et al. 2017, van der Werf et al. 2008). These changes have occurred despite increases in fire weather season length (Jolly et al. 2015). Efforts to better resolve retrospective and future changes in fire activity require refining the host of influences on societal and environmental factors on fire activity. In this study, we analyzed how climate variability influences interannual fire activity in Africa and Australia, the two continents most affected by fire and responsible for over half of the global pyrogenic emissions. We expand on the analysis presented in Andela et al. (2017) by using the most recent Collection 6 MODIS MCD64 Burned Area Product and exploring the explanatory power of a broader suite of climate variables that have been previously shown to explain fire variability (Bowman et al. 2017). We examined which climate metrics show a strong interannual relationship with the amount of burned area and fire size accounting for antecedent and in-season atmospheric conditions. Fire characteristics were calculated using the 500m resolution MCD64A1 product (2002-2016); the analysis was conducted at the ecoregion scale, and further stratified by landcover using a broad aggregation (forest, shrublands and grasslands) of the Landcover CCI maps (CCI-LC, 2014); all agricultural areas fires were excluded from the analysis. The results of the analysis improve our knowledge of climate controls on fire dynamics in the most fire-prone places in the world which is critical for statistical fire and vegetation models. Being able to predict the impact of climate on fire activity has a strategic importance in designing future fire management scenarios, help to avoid degradation of biodiversity and ecosystem services and improve
J.L. Reis Jr.
Full Text Available O presente relato descreve os achados clínicos e anatomopatológicos de um caso de amiloidose renal em um cão macho de nove anos da raça Shar-Pei. O animal apresentava quadro clínico de esporotricose e de insuficiência renal e exames positivos para erlichiose e leishmaniose. No dia anterior ao óbito, o cão apresentou apatia, desidratação e anúria. À necropsia foram observados inúmeros pontos milimétricos esbranquiçados localizados no córtex renal e hepatização do lobo diafragmático esquerdo. O achado histológico mais importante foi deposição de material eosinofílico, amorfo e acelular localizado nos tufos glomerulares que se corou positivamente pelo vermelho congo (amilóide. Observaram-se nefrite supurada multifocal, espessamento da cápsula de Bowman e broncopneumonia supurada crônica, com fibrose intensa. A origem da amiloidose, no presente caso, poderia ser hereditária, assemelhando-se à amiloidose familiar descrita em cães da raça Shar-Pei, ou ser devida à inflamação supurada crônica e/ou leishmaniose.The clinical and pathological findings of a case of renal amyloidosis in a nine-year-old male Shar-Pei dog were described. Clinically, there were signs of sporotrichosis and renal insufficiency, besides being positive to leishmaniasis and ehrlichiosis. On the day before death, the animal became apathetic, dehydrated and anuric. On gross examination, there were several whitish millimetric spots seen widespread in both renal cortices and consolidation of the left diaphragmatic pulmonary lobe. The most important microscopic finding was a deposition of amorphous acellular material on the glomerular tufts which stained positively by congo red stain. Other changes were multifocal suppurative nephritis, thickening of the Bowman capsule and chronic suppurative bronchopneumonia. The origin of the amyloidosis in this case could be hereditary, being similar to familiar amyloidosis described in Shar-Pei breed, or due to
Several options for weapons fissile-material disposition, such as once-through mixed- oxide (MOX) fuel in reactors or immobilisation in waste glass, would result in end products requiring geologic disposal. The criticality potential of the fissile end products containing U-235 and Pu-239 and the associated consequences in a geologic setting are important considerations for the final disposal of these materials. The possibility of underground criticality, and especially autocatalytic criticality, is affected by (1) groundwater leaking into a failed waste container, (2) preferential leaching of neutron absorbers or of fissile material from a failed container, and (3) preferential deposition of fissile material in the surrounding rock. Bowman and Venneri have pointed out that fissile material mixed with varying compositions of water and silica can undergo a nuclear chain reaction. Some configurations can become autocatalytically supercritical resulting in considerable energy release, terminated finally by disassembly. Some reviews rejected the Bowman and Venneri warning as implausible because of low probabilities of scenarios that could lead to such configurations. Sanchez et al. reported possible supercritical conditions in systems of Pu-SiO 2 -H 2 O and Pu-tuff-H 2 O but concluded that the probability of forming such combinations is extremely low. Kastenberg et al. studied the potential for autocatalytic criticality of plutonium or highly enriched uranium in the proposed Yucca Mountain geologic repository. They concluded that plutonium or uranium could, theoretically, become supercritical, but that such criticality is unlikely given the hydrology, geology and geochemistry of the Yucca Mountain site. These studies are not definitive. The possibility of criticality exists. Detailed mechanisms have not been sufficiently studied for clear conclusions on the probabilities of occurrence. More technical analysis is needed to understand the potential for underground
Alexandrakis, George; Karditsa, Aikaterini; Poulos, Serafim; Kampanis, Nikos
The formation of pocket beaches is a result of a large number of processes and mechanisms that vary on space and time scales. This study aims in defining the planform characteristics of pocket beaches in Crete Isl. and to determine their sheltering effect, embaymentization and their status of equilibrium. Thus, data from 30 pocket beaches along the coastline of Crete, with different geomorphological and hydrodynamical setting, were collected. Planform parameters were applied and coastal planview indices from the bibliography were applied. The parameters included: length and orientation of the headlands between the pocket beach; length between the bay entrance and the center of the beach; lengths of the i) embayed shoreline, ii) embayed beach, iii) beach segment located at the shadow of a headland; linear distance and orientation between the edges of the embayed beach; direction of the incident wave energy flux; wave crest obliquity to the control line; beach area, maximum beach width and headland orientation and river/ torrent catchment areas in beach zones that an active river system existed (Bowman et al.2009). For the morphological mapping of the study areas, 1:5000 orthophoto maps were used. Wave regime has been calculated with the use of prognostic equations and utilising local wind data (mean annual frequency of wind speed and direction), provided by the Wind and Wave Atlas of the Eastern Mediterranean Sea. The diffraction and refraction of the waves has been simulated with the use of numerical models. The study shows that Cretan pocket beaches display a wide range of indentation, suggesting that is the result of several parameters that include tectonics, coastal hydrodynamics and river catchment areas. The more indented bays are, the shorter their beaches become, while low-indented pocket beaches are the widest and the longest ones. Beaches with headland with large length appear to be more protected and receive smaller amount of wave energy. Most of the
Kriz, Wilhelm; LeHir, Michel
Studies of glomerular diseases in animal models show that progression toward nephron loss starts with extracapillary lesions, whereby podocytes play the central role. If injuries remain bound within the endocapillary compartment, they will undergo recovery or be repaired by scaring. Degenerative, inflammatory and dysregulative mechanisms leading to nephron loss are distinguished. In addition to several other unique features, the dysregulative mechanisms leading to collapsing glomerulopathy are particular in that glomeruli and tubules are affected in parallel. In contrast, in degenerative and inflammatory diseases, tubular injury is secondary to glomerular lesions. In both of the latter groups of diseases, the progression starts in the glomerulus with the loss of the separation between the tuft and Bowman's capsule by forming cell bridges (parietal cells and/or podocytes) between the glomerular and the parietal basement membranes. Cell bridges develop into tuft adhesions to Bowman's capsule, which initiate the formation of crescents, either by misdirected filtration (proteinaceous crescents) or by epithelial cell proliferation (cellular crescents). Crescents may spread over the entire circumference of the glomerulus and, via the glomerulotubular junction, may extend onto the tubule. Two mechanisms concerning the transfer of a glomerular injury onto the tubulointerstitium are discussed: (1) direct encroachment of extracapillary lesions and (2) protein leakage into tubular urine, resulting in injury to the tubule and the interstitium. There is evidence that direct encroachment is the crucial mechanism. Progression of chronic renal disease is underlain by a vicious cycle which passes on the damage from lost and/or damaged nephrons to so far healthy nephrons. Presently, two mechanisms are discussed: (1) the loss of nephrons leads to compensatory mechanisms in the remaining nephrons (glomerular hypertension, hyperfiltration, hypertrophy) which increase their
Neveen M. El-Sherif
Full Text Available Background: Naphthalene (NA is a common environmental contaminant and is abundant in tobacco smoke. Rosemary (Rosmarinus officinalis is a herb commonly used as a spice and flavoring agents in food processing and is useful in the treatment of many diseases. Aim of the work: To study the nephrotoxicity of NA and to evaluate the possible protective role of rosemary extract in adult male albino rat. Materials and Methods: 25 animals were divided into three groups: Group I (Control group, Group II (NA treated group received NA at a dose of 200 mg/kg/day dissolved in 5 ml/kg corn oil orally by gastric tube, Group III (protected group received rosemary extract (10 ml/kg/day followed after 60 min by NA at the same previous dose orally by gastric tube. The experiment lasted 30 days. The following parameters were studied: Biochemical assessment of renal function, histological, immunohistochemical, morphometric studies and statistical analysis of the results. Results: NA treatment resulted in a highly significant increase in the mean values of serum urea and creatinine. NA induced histological changes in the form of glomerular congestion. Some glomeruli demonstrated marked mesangial expansion and hence that Bowman's spaces were almost completely obliterated. Shrinkage of renal glomeruli with widening of Bowman's spaces could also be seen. Focal tubular dilatation with appearance of casts inside the tubules was observed. Congested peritubular blood vessels and interstitial hemorrhage were also seen. The medullary region demonstrated vascular congestion and fibrosis. Focal cellular infiltration was presented in the interstitium. The renal cortex of NA treated rats showed a noticeable down regulation in alkaline phosphatase positive immunoreactive cells in some proximal convoluted tubules. NA induced up regulation of positive immunoreaction for inducible nitric oxide synthase in the proximal and distal convoluted tubules as well as in the collecting tubules
Encabezado de página Miar USUARIO/A Nombre de usuario/a Adminradar Contraseña •••••••••• No cerrar sesión Iniciar sesión NOTIFICACIONES Vista Suscribirse IDIOMA Escoge idiomaEntregar CONTENIDO DE LA REVISTA Buscar Ámbito de la búsqueda Buscar Examinar Por número Por autor/a Por título Otras revistas TAMAÑO DE FUENTE Make font size smallerMake font size defaultMake font size larger INFORMACIÓN Para lectores/as Para autores/as Para bibliotecarios/as PALABRAS CLAVE Adicciones Adicción Adolescencia Consumo de drogas Consumo de sustancias Demanda Drogas Educación Erotismo Identidad de consumo Jóvenes Modelos de prevención Motivación-tentaciones. Padres Prevención Programas de prevención Rehabilitación Reinserción social Secundaria Trastorno obsesivo compulsivo Tratamiento INICIO ACERCA DE INICIAR SESIÓN REGISTRARSE BUSCAR ACTUAL ARCHIVOS AVISOS ESTADÍSTICAS INDEXACIÓN DIRECTRICES PARA AUTORES FONDO EDITORIAL Inicio > Archivos > Vol. 2, Núm. 2 (2017 VOL. 2, NÚM. 2 (2017 NÚMERO COMPLETO Ver o descargar el número completo\tPDF TABLA DE CONTENIDOS PRESENTACIÓN Presentación Sandra Milena Restrepo Escobar PDF PDF (ENGLISH 161-164 EDITORIAL El eterno retorno Gustavo Adolfo Calderón Vallejo PDF PDF (ENGLISH 165-168 ARTÍCULOS DE INVESTIGACIÓN Identidad de consumo, motivos y creencias en jóvenes fumadores y no fumadores colombianos Marcela Velasco Salamanca,\tConstanza Londoño Pérez,\tMaría Fernanda Forero,\tDiego Páez,\tMarcela Romero,\tCatherine Ruíz PDF 170-192 Consumo de drogas e involucramiento parental entre estudiantes de secundaria de Costa Rica durante el 2015
Jesús Méndez Muñoz
Full Text Available Este artículo tiene como objetivo validar la importancia de un adecuado involucramiento parental en la prevención del consumo de drogas, así como en la disminución de los niveles de prevalencia de consumo, mediante un análisis correlacional de variables. La investigación se realiza a partir de una muestra de 5863 estudiantes de secundaria, como parte de la “IV Encuesta nacional sobre consumo de drogas en población de educación secundaria”, la cual se aplicó durante el 2015 a un grupo representativo de estudiantes de 50 colegios de todo Costa Rica. El instrumento utilizado contó con 109 preguntas distribuidas en siete secciones distintas, desde información personal y académica básica, a conductas de riesgo, bajo los efectos de sustancias psicoactivas. Entre los principales resultados se encuentra que aproximadamente 6 de cada 10 estudiantes reportan un mayor involucramiento por parte de sus padres, además, se rescatan mayores niveles de prevalencia en consumo de alcohol, tabaco y marihuana entre los jóvenes con menor involucramiento parental; de igual forma, aquellos jóvenes con una mejor relación con sus padres presentan una percepción de alto riesgo mayor sobre conductas de consumo. Se encontraron también relaciones estadísticamente significativas entre el consumo de padres y su nivel de involucramiento, evidenciando que aquellos que consumen en menor medida presentan un mayor nivel de involucramiento.
Gao Hong; Li Gaofeng; Wu Qinhong; Li Xuenan; Zhong Qiuzi; Xu Yonggang
Objective: To retrospectively investigate clinical outcomes and prognostic factors in localized prostate cancer treated with neoadjuvant endocrine therapy followed by intensity modulated radiotherapy (IMRT). Methods: Between March 2003 and October 2008, 54 localized prostate cancer treated by IMRT were recruited. All patients had received endocrine therapy before IMRT. The endocrine therapy included surgical castration or medical castration in combination with antiandrogens. The target of IMRT was the prostate and seminal vesicles with or without pelvis. The biochemical failure was defined according to the phoenix definition. By using the risk grouping standard proposed by D'Amico, patients were divided into three groups: low-risk group (n = 5), intermediate-risk group (n = 12), and high-risk group (n = 37). Kaplan-Meier method was used to calculate the overall survival rate. Prognostic factors were analyzed by univariate and multiple Cox regression analysis. Results: The follow-up rate was 98%. The number of patients under follow-up was 39 at 3 years and 25 at 5 years. Potential prognostic factors, including risk groups, mode of endocrine therapy, time of endocrine therapy, phoenix grouping before IMRT, the prostate specific antigen doubling time (PSADT) before radiotherapy, PSA value before IMRT, interval of endocrine therapy and IMRT, irradiation region, and irradiation dose were analyzed by survival analysis. In univariate analysis, time of endocrine therapy (75 % vs 95 %, χ 2 = 6. 45, P = 0. 011), phoenix grouping before IMRT (87% vs 96%, χ 2 = 4. 36, P = 0. 037), interval of endocrine therapy and IMRT (80% vs 95%, χ 2 = 11.60, P= 0. 001), irradiation dose (75% vs 91%, χ 2 =5.92, P= 0. 015) were statistically significant prognostic factors for 3 - year overall survival , and risk groups (85 vs 53 vs 29, χ 2 = 6. 40, P =0. 041) and PSADT before IMRT (62 vs 120, U =24. 50, P =0. 003) were significant factors for the median survival time. In the multiple Cox
Rosoldi, Marco; Madonna, Fabio; Pappalardo, Gelsomina; Vande Hey, Joshua; Zheng, Yunhui; Vaisala Team
aim to improve the data consistency and comparability (D'Amico et al., 2016; Mattis et al., 2016). A first statistical analysis of simultaneous observations performed by all the instruments during the campaign reveals that ceilometers have fairly good performances in aerosol profiling in the lower troposphere, up to an altitude of about 2000 m above the ground, but they are limited at higher altitudes. Among the considered devices, the mini-MPL shows the best performances with discrepancies limited to 10 % throughout the troposphere. Further analysis is ongoing also to assess the stability of the considered lidar technologies with respect to variation of working and environment temperature, aerosol loading, laser operation.
Measuring prostate-specific quality of life in prostate cancer patients scheduled for radiotherapy or radical prostatectomy and reference men in Germany and Canada using the Patient Oriented Prostate Utility Scale-Psychometric (PORPUS-P
Full Text Available Abstract Background The PORPUS-P is a short questionnaire for measuring prostate-specific quality of life (QoL, which was designed in Canada for use in prostate cancer (PC patients. We aimed to generate a German version and compare PORPUS-P scores of German reference men from the general population, and German and Canadian patients with newly diagnosed PC who were scheduled to receive radical prostatectomy (RP or radiotherapy (RT. Methods The study sample consisted of 988 reference men, 121 German and 66 Canadian PC patients scheduled for RT, and 371 German and 68 Canadian PC patients scheduled for RP. All men completed the PORPUS-P (German postal questionnaire, Canada personal interview. Data were gathered from PC patients before the start of therapy. Results Canadian patients were better educated than the German patients, and fewer were retired. Patients scheduled to receive RT were older and more were retired. German RT patients had lower D'Amico risk scores and pre-treatment Gleason scores than RP patients, and Canadian RT patients had higher pre-treatment PSA than RP patients. Urinary and sexual dysfunction were seen in PC patients (especially RT patients, but were also common in the German reference men. Crude mean PORPUS-P scores differed statistically significant between German RT and RP and Canadian RP and RT patients, with RT patients having higher QoL scores. The differences in age-adjusted mean PORPUS-P scores between reference men and RP patients were not clinically significant, while RT patients had (clinically significantly lower scores than the reference men. Conclusion The German translation of the PORPUS-P appears to be a short and feasible tool for assessing prostate-specific QoL. Although we found a similar response pattern, Canadian and German PC patients scheduled to receive RT or RP rated their pre-treatment quality of life on different levels, which reveals the need for national reference data. Problems in several Qo
Lankford, S.P.; Pollack, A.; Zagars, G.K.
Purpose: Although the pretreatment serum prostate specific antigen level (PSAL) is the single most significant predictor of local and biochemical control in prostate cancer patients treated with radiotherapy, it is relatively insensitive for patients with a PSAL in the intermediate range (4-20 ng/ml). PSA density (PSAD) has been shown to be slightly more predictive of outcome than PSAL for this intermediate risk group; however, this improvement is small and of little use clinically. PSA cancer volume (PSACV) is an estimate of cancer volume based on PSA that was recently described by D'Amico and Propert (IJROBP 32:232, 1995) as providing significant and independent prognostic information in addition to PSAL. We report here a detailed comparison between this new prognostic factor, PSAL, and PSAD. Methods and Materials: The records of 356 patients treated with definitive external beam radiotherapy for regionally localized (T1-4, Nx, M0) adenocarcinoma of the prostate were reviewed. Each patient had a PSAL, biopsy Gleason score, and pretreatment prostate volume by transrectal ultrasonography. The median PSAL was 9.3 ng/ml and 66% had Gleason scores in the 2-6 range. The median radiation dose was 66.0 Gy and the median follow-up for those living was 27 months. PSACV is a calculated parameter that takes into account PSAL (total PSA), ultrasonographic prostate volume (estimate of PSA from benign epithelium), and Gleason grade (estimate of PSA per tumor volume). The median PSACV was 1.43 cc. Biochemical failure was defined as increases in two consecutive follow-up PSA levels, one increase by a factor > 1.5, or an absolute increase of > 1 ng/ml. Local failure was defined as a cancer-positive prostate biopsy, usually undertaken because of evidence of biochemical failure. Results: The distributions of PSACV and PSAL were similar and, when normalized by log-transformation, were highly correlated (p 4 cc, as compared to those with a PSACV ≤ 0.5 cc, was over 30%. Conclusion
Prostate Specific Antigen (PSA) as Predicting Marker for Clinical Outcome and Evaluation of Early Toxicity Rate after High-Dose Rate Brachytherapy (HDR-BT) in Combination with Additional External Beam Radiation Therapy (EBRT) for High Risk Prostate Cancer.
Ecke, Thorsten H; Huang-Tiel, Hui-Juan; Golka, Klaus; Selinski, Silvia; Geis, Berit Christine; Koswig, Stephan; Bathe, Katrin; Hallmann, Steffen; Gerullis, Holger
High-dose-rate brachytherapy (HDR-BT) with external beam radiation therapy (EBRT) is a common treatment option for locally advanced prostate cancer (PCa). Seventy-nine male patients (median age 71 years, range 50 to 79) with high-risk PCa underwent HDR-BT following EBRT between December 2009 and January 2016 with a median follow-up of 21 months. HDR-BT was administered in two treatment sessions (one week interval) with 9 Gy per fraction using a planning system and the Ir192 treatment unit GammaMed Plus iX. EBRT was performed with CT-based 3D-conformal treatment planning with a total dose administration of 50.4 Gy with 1.8 Gy per fraction and five fractions per week. Follow-up for all patients was organized one, three, and five years after radiation therapy to evaluate early and late toxicity side effects, metastases, local recurrence, and prostate-specific antigen (PSA) value measured in ng/mL. The evaluated data included age, PSA at time of diagnosis, PSA density, BMI (body mass index), Gleason score, D'Amico risk classification for PCa, digital rectal examination (DRE), PSA value after one/three/five year(s) follow-up (FU), time of follow-up, TNM classification, prostate volume, and early toxicity rates. Early toxicity rates were 8.86% for gastrointestinal, and 6.33% for genitourinary side effects. Of all treated patients, 84.81% had no side effects. All reported complications in early toxicity were grade 1. PSA density at time of diagnosis ( p = 0.009), PSA on date of first HDR-BT ( p = 0.033), and PSA on date of first follow-up after one year ( p = 0.025) have statistical significance on a higher risk to get a local recurrence during follow-up. HDR-BT in combination with additional EBRT in the presented design for high-risk PCa results in high biochemical control rates with minimal side-effects. PSA is a negative predictive biomarker for local recurrence during follow-up. A longer follow-up is needed to assess long-term outcome and toxicities.
Full Text Available Anton Orlin, Aalya Fatoo, Joshua Ehrlich, Donald J D'Amico, RV Paul Chan, Szilárd KissDepartment of Ophthalmology, Weill Cornell Medical College, New York, NY, USAPurpose: To describe ultra-widefield fluorescein angiography (UWFA findings in eyes with white without pressure (WWOP and in eyes without any obvious peripheral chorioretinal disease, and to determine if a difference exists between these two groups.Methods: A retrospective review of 379 eyes undergoing diagnostic UWFA using the Optos 200Tx imaging system. Eyes were excluded if the quality of the color photograph or UWFA prevented reliable evaluation. Eyes were also excluded if there was any evidence of peripheral retinal or choroidal disease, which was thought to have an effect on UWFA (eg, peripheral background diabetic or hypertensive retinopathy, vein occlusion, or any other peripheral vascular disorder. Eyes were determined to have WWOP, based on a dilated fundus examination and color fundus photography that contained areas of peripheral retinal whitening consistent with the diagnosis. UWFA was evaluated by trained masked graders, and determined to have or not have peripheral vascular leakage and/or staining.Results: Of the 379 eyes evaluated, 45 eyes were included in the study. Twelve eyes were determined to have peripheral WWOP; 33 eyes did not have WWOP on examination or color fundus photography. Three common UWFA peripheral patterns were visualized. Eyes with and without WWOP were grouped into one of three patterns. The majority of eyes without WWOP demonstrated UWFA pattern one (69.7%, while those in the WWOP group demonstrated pattern three (50%. The distribution of UWFA patterns is statistically different between those with and without WWOP (P = 0.002. In eyes without WWOP, in patients with no documented systemic microvascular disease (diabetes, hypertension, 71.4% of eyes had UWFA pattern one while 14.3% had both patterns two and three.Conclusion: This study is one of the
Stanica, Dumitru; Armand Stanica, Dragos
In this paper, we used the geomagnetic time series collected in real time by the electromagnetic monitoring system, placed at the Geomagnetic Observatory Provita de Sus, to emphasize possible relationships between the pre-seismic anomalous behavior of the normalized function Bzn and M5.7 earthquake occurrence in Vrancea seismic active zone, on September 24, 2016. It has already been demonstrated (Stanica and Stanica, 2012, Stanica et al., 2015) that for a 2D geoelectric structure, in pre-seismic conditions, the normalized function Bzn has significant changes in magnitudes due to the electrical conductivity changes, possibly associated with the earthquake-induced rupture-processes and high-pressure fluid flow through the faulting systems developed inside the Vrancea seismogenic volume and along the Carpathian electrical conductivity anomaly. In this circumstances, the daily mean distributions of the Bzn = Bz/Bperp (where Bz is vertical component of the geomagnetic field; Bperp is geomagnetic component perpendicular to the geoelectric strike) and its standard deviation (SD) are performed in the ULF frequency range 0.001Hz to 0.0083Hz by using both the FFT band-pass filter analysis and statistical analysis based on a standardized random variable equation. After analyzing the pre-seismic anomalous intervals, a pre-seismic geomagnetic signal greater than 5 SD was identified on September 22, 2016, what means a lead time of 2 days before the M5.7 earthquake occurred on September 24, emphasized in real time on the web site (www.geodin.ro). The final conclusion is that the proposed geomagnetic methodology might be used to provide suitable information for the extreme seismic hazard assessment and risk mitigation. References: Dumitru Stanica and Dragos Armand Stanica, Earthquakes precursors, in "Earthquake Research and Analysis-Statistical Studies, Observations and Planning" Book 5, edited by: Dr. Sebastiano D'Amico, ISBN 978-953-51-0134-5, InTech open access publisher
Tan, Nelly; Shen, Luyao; Khoshnoodi, Pooria; Alcalá, Héctor E; Yu, Weixia; Hsu, William; Reiter, Robert E; Lu, David Y; Raman, Steven S
We sought to identify the clinical and magnetic resonance imaging variables predictive of biochemical recurrence after robotic assisted radical prostatectomy in patients who underwent multiparametric 3 Tesla prostate magnetic resonance imaging. We performed an institutional review board approved, HIPAA (Health Insurance Portability and Accountability Act) compliant, single arm observational study of 3 Tesla multiparametric magnetic resonance imaging prior to robotic assisted radical prostatectomy from December 2009 to March 2016. Clinical, magnetic resonance imaging and pathological information, and clinical outcomes were compiled. Biochemical recurrence was defined as prostate specific antigen 0.2 ng/cc or greater. Univariate and multivariate regression analysis was performed. Biochemical recurrence had developed in 62 of the 255 men (24.3%) included in the study at a median followup of 23.5 months. Compared to the subcohort without biochemical recurrence the subcohort with biochemical recurrence had a greater proportion of patients with a high grade biopsy Gleason score, higher preoperative prostate specific antigen (7.4 vs 5.6 ng/ml), intermediate and high D'Amico classifications, larger tumor volume on magnetic resonance imaging (0.66 vs 0.30 ml), higher PI-RADS® (Prostate Imaging-Reporting and Data System) version 2 category lesions, a greater proportion of intermediate and high grade radical prostatectomy Gleason score lesions, higher pathological T3 stage (all p <0.01) and a higher positive surgical margin rate (19.3% vs 7.8%, p = 0.016). On multivariable analysis only tumor volume on magnetic resonance imaging (adjusted OR 1.57, p = 0.016), pathological T stage (adjusted OR 2.26, p = 0.02), positive surgical margin (adjusted OR 5.0, p = 0.004) and radical prostatectomy Gleason score (adjusted OR 2.29, p = 0.004) predicted biochemical recurrence. In this cohort tumor volume on magnetic resonance imaging and pathological variables, including Gleason score
Author of the 1998 book, Last Oasis: Facing Water Scarcity, Dr. Sandra Postel predicts big water availability problems as populations of so-called “water-stressed” countries jump perhaps six fold over the next 30 years. The author has reported on this in his previous AGU presentations. In the next four decades, more than half of the world’s population will have to deal with sever water shortages. The United States has been blessed with several large fresh water lakes. In spite of having this fresh water supply, some states like Arizona could be facing sever fresh water shortages in the next couple of decades. Sid Wilson, general manager of the Central Arizona Project has indicated "It's not a question of if there is a water shortage anymore. It is in reality, when there will be a water shortage. " Several states share water from the Colorado river. The river has limited water supply to cater to the needs of Arizona, Nevada, California, Colorado, New Mexico, Utah and Wyoming. World Health Organization, NASA, Department of the Interior, NOAA and several organizations have observed that there is a real water shortage crisis. This is because the world’s population has tripled in the twentieth century. This has resulted in a six-fold increase of water usage. Fresh water supply is limited. This is because water cannot be replaced with an alternative. It is important to observe that petroleum can be replaced with alternative fuel resources. It is necessary to recognize that fact that irrigation necessitates almost 65% to 70% of water withdrawal. Industry may utilize about 20% and domestic consumption is about 10% Evaporation from reservoirs is also a major factor, depending upon the climate and environment. Therefore there is an urgent need for all the countries to establish a strong, sound, sensible and sustainable management program for utilizing the available water supplies efficiently (Narayanan, 2008). References: Narayanan, Mysore. (2008). Hydrology, Water
Celmira Laza V.
Full Text Available Resumen Objetivo: explorar la existencia de barreras de acceso a los servicios de salud en las historias de mujeres con cáncer de mama, que han recibido apoyo de seis ong colombianas. Metodología: se llevó a cabo un estudio cualitativo descriptivo interpretativo, en cinco ciudades colombianas: Bogotá, Medellín, Cali, Valledupar y Santa Marta, incluyendo 44 mujeres apoyadas por seis ong. Se realizaron grupos focales y entrevistas en profundidad. Resultados: en el proceso emergieron cuatro categorías: barreras ligadas a los determinantes estructurales, barreras originadas en los determinantes intermedios, herramientas para enfrentar las barreras y una categoría que hace referencia a la oportunidad de obtener un diagnóstico y un tratamiento de cáncer de mama. A partir de estas categorías, se propone un modelo de barreras de acceso en cáncer de mama, desde la perspectiva de los determinantes sociales. Discusión: a pesar de los esfuerzos del país por mejorar la oportunidad en prevención, diagnóstico y tratamiento del cáncer —incluyendo la promulgación de la ley 1384 de 2010 (Ley Sandra Ceballos—, las mujeres con cáncer de mama enfrentan barreras de acceso a los servicios de salud, que están determinadas socialmente, y frente a las cuales el sistema muestra cierto nivel de incapacidad. Abstract Objective: to explore the existence of barriers to healthcare access in the narratives of women with breast cancer who have received the support of six Colombian NGOs. Methodology: a descriptive qualitative interpretive study was carried out in five Colombian cities: Bogotá, Medellín, Cali, Santa Marta and Valledupar. Data was collected through focus groups and interviews with 44 women supported by six NGOs. Results: in the process, four categories emerged: barriers linked to structural determinants, barriers arising from intermediate determinants, tools to address barriers and a category referring to the opportunity for diagnosis and
Interconexões entre Linguística Aplicada e práticas de atenção à saúde: linguagem e identidades na prevenção de DSTs/Aids entre travestis profissionais do sexo Interconnections between Applied Linguistics and health care practices: language and identity in the prevention of STDs / AIDS among transvestite sex workers
Full Text Available Este artigo propõe aproximar a Linguística Aplicada de um contexto pouco estudado nos estudos da linguagem no Brasil: a prevenção de DST/Aids. Com base em uma perspectiva não essencialista das relações entre linguagem e identidades sociais, discute-se a importância de atentarmos ao uso de linguagem nesse contexto e descreve-se a construção interacional de identidades em intervenções para distribuição de preservativos entre travestis que se prostituem em uma região urbana do sul do Brasil. Os dados indicam que, durante as intervenções, Sandra e Márcia, mulheres em gênero e sexo, engajam-se em interações nas quais utilizam intertextos identitários associados a identidades não tradicionais e, assim, produzem o efeito de adequação de suas identidades às travestis e ao contexto interacional onde se inserem. Argumenta-se que linguagem, identidade e intertextualidade são construtos fundamentais para entendermos esse contexto interacional e para o combate à disseminação de DST/Aids.This paper proposes to approach Applied Linguistics to a little studied context in language studies in Brazil: the prevention of STD/AIDS. Based on a non-essentialist view of the relationship between language and social identities, it discusses the importance of minding the use of language in this context and describes the interactional construction of identities in interventions for distribution of condoms among transvestite prostitutes in an urban region of Southern Brazil. Data indicate that during the talks, Sandra and Marcia, female gender and sex, engage in interactions in which they use identity inter-texts associated with non-traditional identities and thus produce the effect of the adequacy of their identities to the transvestites and to the interactional context in which they operate. It argues that language, identity and inter-textuality are fundamental constructs to understand this interactional context and to address the spread of
Orlanda Oliveira Bueno
Full Text Available ResumoEste relatório é resultado do estágio de docência em educação infantil III sob a orientação da Professora Sandra Luzia Wrobel Straub da professora. MS. Lenita Korbes do curso de pedagogia da Unemat, Campus de Sinop/MT. Foi realizado as observações nos dias 29/ 30/ 31/de Novembro de 2013 e a regência entre os dias05/11/2013 á 15/11/ 2012 dando um total de 52 horas de estágio no CMEI as restantes das horas foram na UNEMAT e as professoras deram os encaminhamentos e sanaram as dúvidas, O está localizado na Avenida, André Maggi no jardim São Paulo; nos períodos matutino e vespertino, com uma turma de creche II. Nas datas 08/09/05/2013 retornamos a universidade onde as professoras Sandra Luzia Wrobel Straub e a prof. MS. Lenita Korbes contribuíram na elaboração do plano de aula, Com carga horária total de 76 horas. Tendo como objetivo aprimorar a prática de ensinar as crianças em sala de aula e de compreender como ocorre a ação pedagógica na Educação Infantil, com crianças deidade entre 4 e 5 anos de idade, seguindo um planejamento que cumpriu com o regimento interno da Creche e que foi elaborado de acordo com as fontes teóricas trabalhados no decorrer do curso de pedagogia, na universidade aconteceu à socialização onde trocamos as experiências obtidas durante os estágios e enceramos com uma confraternização. Palavras-chave: ação pedagógica, teoria/prática e educação infantil.
D'Silva, Vijay; Perros, Harry; Stockbridge, Chris
A PACS architecture was simulated to quantify its performance. The model consisted of reading stations, acquisition nodes, communication links, a database management system, and a storage system consisting of magnetic and optical disks. Two levels of storage were simulated, a high-speed magnetic disk system for short term storage, and optical disk jukeboxes for long term storage. The communications link was a single bus via which image data were requested and delivered. Real input data to the simulation model were obtained from surveys of radiology procedures (Bowman Gray School of Medicine). From these the following inputs were calculated: - the size of short term storage necessary - the amount of long term storage required - the frequency of access of each store, and - the distribution of the number of films requested per diagnosis. The performance measures obtained were - the mean retrieval time for an image, - mean queue lengths, and - the utilization of each device. Parametric analysis was done for - the bus speed, - the packet size for the communications link, - the record size on the magnetic disk, - compression ratio, - influx of new images, - DBMS time, and - diagnosis think times. Plots give the optimum values for those values of input speed and device performance which are sufficient to achieve subsecond image retrieval times
Stanojevic, Sladjana P; Barac, Miroljub B; Pesic, Mirjana B; Jankovic, Vanja S; Vucelic-Radovic, Biljana V
The nutritional properties of raw okara obtained as a byproduct from six soybean varieties during hydrothermal cooking (HTC) of soy milk were assessed. The composition and residual activity (rTIA) of trypsin inhibitors (TIs), contents of lectin, proteins, fats, and carbohydrates, and energy values (EV) were correlated with the respective physicochemical properties of soybean and okara. Kunitz (KTI) and Bowman-Birk (BBI) TIs both comprised okara rTIA. TIs content was higher in okara (5.19-14.40%) than in soybean (3.10-12.17%), which additionally enriched okara by cysteine. Contents of KTI (r = 1.00;p < 0.05) and BBI (r = 0.89;p < 0.05) as well as BBI monomeric (r = 0.89;p < 0.05) and polymeric forms (r = 0.95;p < 0.05) in okara and in soybean were strongly correlated. Low urease index activity indicated that okara was heated adequately to inactivate antinutritional factors. The proximate composition of raw okara, advantageous rTIA, and a very low EV (2.74-3.78 kJ/g) qualify this byproduct for potential application in food preparation as a functional ingredient in dietary products.
Moyer, Bruce a.; Bostick, Debra A.; Fowler, Christopher J.; Kang, Hyun-Ah; Ruas, Alexandre; Delmau, Laetitia H.; Haverlock, Tamara J.; Llinares, Jose M.; Hossain, Alamgir; Kang, S. O.; Bowman-James, Kristin; Shriver, James A.; Marquez, Manuel; Sessler, Jonathan L.
The major thrust of this project led by the University of Kansas (Prof. Kristin Bowman-Jones) entails the exploration of the principles of recognition and separation of sulfate by the design, synthesis, and testing of novel sulfate extractants. A key science need for the cleanup of tank wastes at Hanford has been identified in developing methods to separate those bulk waste components that have low solubilities in borosilicate glass. Sulfate has been identified as a particularly difficult and expensive problem in that its concentration in the waste is relatively high, its solubility in glass is especially low, and it interferes with the performance of both vitrification equipment and the glass waste form. The new extractants will be synthesized by the University of Kansas and the University of Texas, Austin. Oak Ridge National Laboratory (ORNL) is subjecting the new extractants to experiments that will determine their properties and effectiveness in separating sulfate from the major competing anions in the waste, especially nitrate. Such experiments will entail primarily liquid-liquid extraction. Current efforts focus on exciting new systems in which the anion receptors act as synergists for anion exchange
Sessler, Jonathan L.
The major thrust of this project, led by the University of Kansas (Prof. Kristin Bowman-James), entails an exploration of the basic determinants of anion recognition and their application to the design, synthesis, and testing of novel sulfate extractants. A key scientific inspiration for the work comes from the need, codified in simple-to-appreciate terms by the Oak Ridge National Laboratory component of the team (viz. Dr. Bruce Moyer), for chemical entities that can help in the extractive removal of species that have low solubilities in borosilicate glass. Among such species, sulfate anion, has been identified as particularly insidious. Its presence interferes with the vitrification process, thus rendering the remediation of tank waste from, e.g., the Hanford site far more difficult and expensive. The availability of effective extractants, that would allow for the separation of separating sulfate from the major competing anions in the waste, especially nitrate, could allow for pre-vitrification removal of sulfate via liquid-liquid extraction. The efforts at The University of Texas, the subject of this report, have thus concentrated on the development of new sulfate receptors. These systems are designed to increase our basic understanding of anion recognition events and set the stage for the development of viable sulfate anion extractants. In conjunction with the Oak Ridge National Laboratory (ORNL) members of the research team, several of these new receptors were studied as putative extractants, with two of the systems being shown to act as promising synergists for anion exchange.
This annual report documents the Uranium Mill Tailings Remedial Action (UMTRA) Project environmental monitoring and protection program. The UMTRA Project routinely monitors radiation, radioactive residual materials, and hazardous constituents at associated former uranium tailings processing sites and disposal sites. At the end of 1994, surface remedial action was complete at 14 of the 24 designated UMTRA Project processing sites: Canonsburg, Pennsylvania; Durango, Colorado; Grand Junction, Colorado; Green River Utah, Lakeview, Oregon; Lowman, Idaho; Mexican Hat, Utah; Riverton, Wyoming; Salt Lake City, Utah; Falls City, Texas; Shiprock, New Mexico; Spook, Wyoming, Tuba City, Arizona; and Monument Valley, Arizona. Surface remedial action was ongoing at 5 sites: Ambrosia Lake, New Mexico; Naturita, Colorado; Gunnison, Colorado; and Rifle, Colorado (2 sites). Remedial action has not begun at the 5 remaining UMTRA Project sites that are in the planning stage. Belfield and Bowman, North Dakota; Maybell, Colorado; and Slick Rock, Colorado (2 sites). The ground water compliance phase of the UMTRA Project started in 1991. Because the UMTRA Project sites are.` different stages of remedial action, the breadth of the UMTRA environmental protection program differs from site to site. In general, sites actively undergoing surface remedial action have the most comprehensive environmental programs for sampling media. At sites where surface remedial action is complete and at sites where remedial action has not yet begun, the environmental program consists primarily of surface water and ground water monitoring to support site characterization, baseline risk assessments, or disposal site performance assessments.
Michel Guerra Almaguer
Full Text Available Las opciones quirúrgicas con la utilización del láser excímer en determinadas entidades corneales reporta importantes beneficios. La queratopatía en banda, considerada como una degeneración de la córnea superficial caracterizada por la presencia de depósitos de calcio en la membrana de Bowman, es una de las afecciones corneales que han mostrado alentadores resultados con la realización de la queratectomía fototerapéutica. Se presenta un paciente de 68 años, del sexo femenino y piel blanca, con antecedentes de uveítis anterior. En la consulta refirió sensación de cuerpo extraño del ojo derecho. En la exploración oftalmológica del ojo derecho se apreciaron en la córnea superficial depósitos de color blanco-grisáceo de localización interpalpebral. Los estudios refractivos realizados constataron una disminución marcada de la agudeza visual de cuenta dedos en ambos ojos. Se le realizó queratectomía fototerapéutica del ojo derecho y mejoró la sintomatología ocular.
Soto-Rodriguez, I.; Pulido-Camarillo, E.; Hernandez-Diaz, E.; Alexander-Aguilera, A.; Garcia, H.S.
The purpose of this study was to provide evidence that dietary CLA can prevent the pathogenesis of metabolic syndrome in tissue structure, suggesting potential benefits in the onset of this syndrome. Wistar male spontaneous hypertensive rats (SHR), were classified into two groups that were fed a standard diet for eight weeks: one with 7.5% sunflower oil (V-SHR group), and the other with 6% sunflower oil and 1.5% CLA (CLA-SHR group). A control healthy group consisted of Kyoto-Wistar male rats fed the standard diet with 7.5% sunflower oil. The animals were sacrificed, and sections of liver, kidneys and aorta were fixed in 10% formaldehyde, and then stained with Hematoxylin and Eosin. Only in the V-SHR group, the stain of the aorta indicated irregular endothelial morphology; liver parenchyma was characterized by an infiltration of inflammatory neutrophils, fibrosis, thickening of the portal vein epithelium, hepatocyte hyperplasia and steatosis. The renal tissue of this group evidenced hyperplasia in the cells of the endothelial of Bowman's capsule. Abnormal histological changes were not observed in either the control group of the rats fed with CLA, suggesting a protective role of CLA in the onset of metabolic syndrome.
This annual report documents the Uranium Mill Tailings Remedial Action (UMTRA) Project environmental monitoring and protection program. The UMTRA Project routinely monitors radiation, radioactive residual materials, and hazardous constituents at associated former uranium tailings processing sites and disposal sites. At the end of 1994, surface remedial action was complete at 14 of the 24 designated UMTRA Project processing sites: Canonsburg, Pennsylvania; Durango, Colorado; Grand Junction, Colorado; Green River Utah, Lakeview, Oregon; Lowman, Idaho; Mexican Hat, Utah; Riverton, Wyoming; Salt Lake City, Utah; Falls City, Texas; Shiprock, New Mexico; Spook, Wyoming, Tuba City, Arizona; and Monument Valley, Arizona. Surface remedial action was ongoing at 5 sites: Ambrosia Lake, New Mexico; Naturita, Colorado; Gunnison, Colorado; and Rifle, Colorado (2 sites). Remedial action has not begun at the 5 remaining UMTRA Project sites that are in the planning stage. Belfield and Bowman, North Dakota; Maybell, Colorado; and Slick Rock, Colorado (2 sites). The ground water compliance phase of the UMTRA Project started in 1991. Because the UMTRA Project sites are.' different stages of remedial action, the breadth of the UMTRA environmental protection program differs from site to site. In general, sites actively undergoing surface remedial action have the most comprehensive environmental programs for sampling media. At sites where surface remedial action is complete and at sites where remedial action has not yet begun, the environmental program consists primarily of surface water and ground water monitoring to support site characterization, baseline risk assessments, or disposal site performance assessments
Wegener, Alfred R; Meyer, Linda M; Schönfeld, Carl-Ludwig
To investigate the effect of the viscous agents, hydroxypropyl methylcellulose (HPMC), carbomer, povidone, and a combination of HPMC and povidone on corneal density in patients with dry eye disease. In total, 98 eyes of 49 patients suffering from dry eye and 65 eyes of 33 healthy age-matched individuals were included in this prospective, randomized study. Corneal morphology was documented with Scheimpflug photography and corneal density was analyzed in 5 anatomical layers (epithelium, bowman membrane, stroma, descemet's membrane, and endothelium). Corneal density was evaluated for the active ingredients HPMC, carbomer, povidone, and a combination of HPMC and povidone as the viscous agents contained in the artificial tear formulations used by the dry eye patients. Data were compared to the age-matched healthy control group without medication. Corneal density in dry eye patients was reduced in all 5 anatomical layers compared to controls. Corneal density was highest and very close to control in patients treated with HPMC containing ocular lubricants. Patients treated with lubricants, including carbomer as the viscous agent displayed a significant reduction of corneal density in layers 1 and 2 compared to control. HPMC containing ocular lubricants can help to maintain physiological corneal density and may be beneficial in the treatment of dry eye disease.
Tobiska, W.; Bouwer, D.; Schunk, R.; Garrett, H.; Mertens, C.; Bowman, B.
There have been notable successes during the past decade in the development of operational space environment systems. Examples include the Magnetospheric Specification Model (MSM) of the Earth's magnetosphere, 2000; SOLAR2000 (S2K) solar spectral irradiances, 2001; High Accuracy Satellite Drag Model (HASDM) neutral atmosphere densities, 2004; Global Assimilation of Ionospheric Measurements (GAIM) ionosphere specification, 2006; Hakamada-Akasofu-Fry (HAF) solar wind parameters, 2007; Communication Alert and Prediction System (CAPS) ionosphere, high frequency radio, and scintillation S4 index prediction, 2008; and GEO Alert and Prediction System (GAPS) geosynchronous environment satellite charging specification and forecast, 2008. Operational systems that are in active operational implementation include the Jacchia-Bowman 2006/2008 (JB2006/2008) neutral atmosphere, 2009, and the Nowcast of Atmospheric Ionizing Radiation for Aviation Safety (NAIRAS) aviation radiation model using the Radiation Alert and Prediction System (RAPS), 2010. U.S. national agency and commercial assets will soon reach a state where specification and prediction will become ubiquitous and where coordinated management of the space environment and space weather will become a necessity. We describe the status of the CAPS, GAPS, RAPS, and JB2008 operational development. We additionally discuss the conditions that are laying the groundwork for space weather management and estimate the unfilled needs as we move beyond specification and prediction efforts.
Eriksson, C.; Brittebo, E.B.
The bioactivation and binding of 14 C-labelled 1,1,2,2-tetrachloroethane (TCE) in the tissues of C57B1 mice were studied. As shown by autoradiography with heated and organic solvent-extracted tissue sections of i.v. injected mice, a high and selective localization of bound metabolites occurred in the nasal olfactory mucosa, preferentially in the Bowman's glands. High levels of bound metabolites were also present in epithelia of the trachea, bronchi and bronchioli and in the squamous epithelia of the oral cavity, tongue and esophagus. An epithelial binding was observed in tissue slices incubated with 14 C-TCE. Incubation of 14 C-TCE with homogenates of the olfactory mucosa and liver showed that the olfactory mucosa had a higher ability to activate 14 C-TCE into products that become irreversibly bound to protein. Addition of metyrapone, glutathione or sodium dithionite to the incubations decreased the level of irreversible binding, suggesting that the activation of TCE to reactive products is mediated via an oxidative cytochrome P-450 dependent process in the olfactory mucosa. (orig.)
Franco, Octávio L; dos Santos, Roseane C; Batista, João A N; Mendes, Ana Cristina M; de Araújo, Marcus Aurélio M; Monnerat, Rose G; Grossi-de-Sá, Maria Fátima; de Freitas, Sonia M
The cotton boll weevil Anthonomus grandis (Boheman) is one of the major pests of cotton (Gossypium hirsutum L.) in tropical and sub-tropical areas of the New World. This feeds on cotton floral fruits and buds causing severe crop losses. Digestion in the boll weevil is facilitated by high levels of serine proteinases, which are responsible for the almost all proteolytic activity. Aiming to reduce the proteolytic activity, the inhibitory effects of black-eyed pea trypsin/chymotrypsin inhibitor (BTCI), towards trypsin and chymotrypsin from bovine pancreas and from midguts of A. grandis larvae and adult insects were analyzed. BTCI, purified from Vigna unguiculata (L.) seeds, was highly active against different trypsin-like proteinases studied and moderately active against the digestive chymotrypsin of adult insects. Nevertheless, no inhibitory activity was observed against chymotrypsin from A. grandis larval guts. To test the BTCI efficiency in vivo, neonate larvae were reared on artificial diet containing BTCI at 10, 50 and 100 microM. A reduction of larval weight of up to approximately 54% at the highest BTCI concentration was observed. At this concentration, the insect mortality was 65%. This work constitutes the first observation of a Bowman-Birk type inhibitor active in vitro and in vivo toward the cotton boll weevil A. grandis. The results of bioassays strongly suggest that BTCI may have potential as a transgene protein for use in engineered crop plants modified for heightened resistance to the cotton boll weevil.
Calderon, L A; Teles, R C L; Leite, J R S A; Franco, O L; Grossi-de-Sá, M F; Medrano, F J; Bloch, C; Freitas, S M
A 6.5 kDa serine protease inhibitor was purified by anion-exchange chromatography from the crude extract of the Inga umbratica seeds, containing inhibitor isoforms ranging from 6.3 to 6.7 kDa and protease inhibitors of approximately 19 kDa. The purified protein was characterized as a potent inhibitor against trypsin and chymotrypsin and it was named I. umbratica trypsin and chymotrypsin inhibitor (IUTCI). MALDI-TOF spectra of the IUTCI, in the presence of DTT, showed six disulfide bonds content, suggesting that this inhibitor belongs to Bowman-Birk family. The circular dichroism spectroscopy indicates that IUTCI is predominantly formed by unordered and beta-sheet secondary structure. It was also characterized, by fluorescence spectroscopy, as a stable protein at range of pH from 5.0 to 7.0. Moreover, this inhibitor at concentration of 75 microM presented a remarkable inhibitory activity (60%) against digestive serine proteases from boll weevil Anthonomus grandis, an important economical cotton pest.
Prins, Anneke; Mukubi, Josephine Muchwesi; Pellny, Till K; Verrier, Paul J; Beyene, Getu; Lopes, Marta Silva; Emami, Kaveh; Treumann, Achim; Lelarge-Trouverie, Caroline; Noctor, Graham; Kunert, Karl J; Kerchev, Pavel; Foyer, Christine H
The responses of C(3) plants to rising atmospheric CO(2) levels are considered to be largely dependent on effects exerted through altered photosynthesis. In contrast, the nature of the responses of C(4) plants to high CO(2) remains controversial because of the absence of CO(2) -dependent effects on photosynthesis. In this study, the effects of atmospheric CO(2) availability on the transcriptome, proteome and metabolome profiles of two ranks of source leaves in maize (Zea mays L.) were studied in plants grown under ambient CO(2) conditions (350 +/- 20 µL L(-1) CO(2) ) or with CO(2) enrichment (700 +/- 20 µL L(-1) CO(2) ). Growth at high CO(2) had no effect on photosynthesis, photorespiration, leaf C/N ratios or anthocyanin contents. However, leaf transpiration rates, carbohydrate metabolism and protein carbonyl accumulation were altered at high CO(2) in a leaf-rank specific manner. Although no significant CO(2) -dependent changes in the leaf transcriptome were observed, qPCR analysis revealed that the abundance of transcripts encoding a Bowman-Birk protease inhibitor and a serpin were changed by the growth CO(2) level in a leaf rank specific manner. Moreover, CO(2) -dependent changes in the leaf proteome were most evident in the oldest source leaves. Small changes in water status may be responsible for the observed responses to high CO(2,) particularly in the older leaf ranks. © 2010 Blackwell Publishing Ltd.
Micali, Antonio; Roszkowska, Anna M; Postorino, Elisa I; Rania, Laura; Aragona, Emanuela; Wylegala, Edward; Nowinska, Anna; Ieni, Antonio; Calimeri, Sebastiano; Pisani, Antonina; Aragona, Pasquale; Puzzolo, Domenico
Corneal opacities rarely occur in multiple myeloma (MM). Our study correlates the findings of in vivo confocal microscopy (IVCM), a useful diagnostic tool, with histopathological features of corneal opacities appearing in a patient with MM. Case report. A 53-year-old man developed corneal opacities in both eyes, more pronounced in the left eye. After IVCM examination, he underwent penetrating keratoplasty in the left eye, and the button was processed for light and electron microscopy and immunohistochemistry. The diagnosis of MM was made, as confirmed by the elevation of IgGk light chains. IVCM demonstrated hyperreflective areas at the epithelial level, hyperreflective keratocytes of dendritic and lamellar morphology in whole stroma, and hyperreflective endothelial cells. Histopathological examination disclosed many vacuoles in the epithelial cell cytoplasm and a homogenous granular material in the Bowman layer. In stroma, keratocytes of different shape and size, with vesicles laden with an abnormal material, were evident. In Descemet membrane, the posterior nonbanded zone had a honeycomb appearance because of the presence of many roundish spaces among wide-spaced collagen fibers. Endothelial cells demonstrated vesicles filled with a material of uneven electron density. Immunohistochemical analysis showed strong positivity for IgGk light chains in keratocytes and among stromal lamellae. This is the first study describing a correspondence between IVCM features and histopathological alterations observed in corneal opacities in MM. The results of this study improve the current understanding of the pictures obtained by IVCM studies.
Kashtan, C; Fish, A J; Kleppel, M; Yoshioka, K; Michael, A F
We probed epidermal basement membranes (EBM) of acid-urea denatured skin from members of kindreds with Alport-type familial nephritis (FN) for the presence of antigens reactive with Goodpasture sera (GPS) and serum (FNS) from an Alport patient who developed anti-glomerular basement membrane (GBM) nephritis in a renal allograft. By immunoblotting, GPS reacted primarily with the 28,000 molecular weight (mol wt) monomer but also the 24,000 mol wt and 26,000 mol wt monomers of the noncollagenous globular domain (NC1) of type IV collagen from normal human GBM, while FNS identified only the 26,000-mol wt monomer. FNS reacted with EBM of 12 controls and nine unaffected male kindred members but not EBM of eight affected males. Five affected females exhibited interrupted reactivity of FNS with EBM. GPS showed variable reactivity with EBM and was not discriminating with respect to Alport-type FN. FNS did not stain renal basement members of five affected males. However, the EBM, tubular basement membrane, and Bowman's capsules of affected males contained antigens reactive with GPS. These immunochemical studies suggest that the FNS antigen is distinct from Goodpasture antigen(s). The expression of FNS antigen located on the NC1 domain of type IV collagen is altered in basement membranes of patients with Alport-type FN, and the distribution of this antigenic anomaly within kindreds suggests X-linked dominant transmission of a defective gene.
Lanza, Michele; Iaccarino, Stefania; Varricchi, Gilda; D'Errico, Tito; Gironi Carnevale, Ugo Antonello; Bifani, Mario
To evaluate light backscattering (LB) in corneal layers in patients with primary Sjögren's syndrome dry eye (SSDE) utilizing in vivo corneal confocal microscopy (IVCM) and to determine the eventual association with the lacrimal functional test values. A complete ophthalmic evaluation, Schirmer test with and without stimulation, break-up time (BUT) and IVCM were performed on 55 patients affected by SSDE and in an age- and sex-matched cohort of healthy participants (HP). Light backscattering, measures as light reflectivity unit (LRU), detected by IVCM at Bowman's membrane (BM) at 50 μm, at 100 μm and at 200 μm deeper than BM was compared in the two groups. The correlations between LB values and lacrimal function results were evaluated. In patients affected by SSDE, LB was significantly higher (p lacrimal function. Light backscattering (LB) could be very useful for clinical diagnosis and management of SSDE. © 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
The 19th century was a period of momentous scientific discoveries, technological achievements, and societal changes. A beneficiary of these revolutionary upheavals was medical empiricism that supplanted the rationalism of the past giving rise to early modern scientific medicine. Continued reliance on sensory data now magnified by technical advances generated new medical information that could be quantified with increasing precision, verified by repeated experimentation, and validated by statistical analysis. The institutionalization and integration of these methodologies into medical education were a defining step that assured their progress and perpetuation. Major advances were made in the nosography of diseases of the kidney, notably that of the diagnosis of progressive kidney disease from the presence of albuminuria by Richard Bright (1789-1858); and of renal structure and function, notably the demonstration of the continuity of the glomerular capsule with the tubular basement membrane by William Bowman (1816-1892), and the arguments for hemodynamic physical forces mediated glomerular filtration by Carl Ludwig (1816-1895) and for active tubular transport by Rudolf Heidenhain (1834-1897). Improvements in microscopy and tissue processing were instrumental in describing the cellular ultrastructure of the glomerulus and tubular segments, but their integrated function remained to be elucidated. The kidney continued to be considered a tubular secretory organ and its pathology attributed to injury of the interstitium (interstitial nephritis) or tubules (parenchymatous nephritis). © 2012 Wiley Periodicals, Inc.
Only very little was known about the physiology of the kidneys until the middle of the 19th century. The turning point came in 1842 when the famous German physiologist and physician Carl Ludwig (1816-1895) presented a theory about a two-step process (filtration and reabsorption) leading to the excretion of urine. This paper turns the highlights on Ludwig and the period in which he lived. It also tells the story about the anatomical studies in the 17th century and the chemical approaches to urine and kidney physiology in the 18th century preceding the research of Carl Ludwig. The theory of filtration and reabsorption was opposed by another theory (the secretion theory) regarding the kidney as a gland, like for instance the salivary glands. The origin of this theory can be dated back to Marcello Malpighi (1628-1694) in the Renaissance, but it was carried further on by William Bowman (1816-1892) and especially Rudolph Heidenhain (1834-1897) in the 19th century. The research in the 1920's and 1930's marked the end of the fight between the two theories. It proofed that Ludwig was right and it gave him posthumously the recognition that he all the time had deserved.
Crăiţoiu, Stefania; Ciprian, Livezeanu; Rodica, Mănescu; Mihai, Afrem; Anca, Eremia Irina
Pterygium is an epithelial hyperplasia accompanied by a fibrovascular growth originating at the corneo-conjunctival junction, from where the modified limbic cells migrate and surpass the cornea. The studies reviewed show that it is an active process associated with cell growth, remodelling of the connective tissue, angiogenesis and inflammation. Despite the lack of knowledge regarding the pathogenesis of pterygia, epidemiologic evidence suggests that exposure to UV-irradiation may be an initial trigger in the development of this lesion. Other theories include changes of the apoptotic pathway the presence of some active angiogenetic factors or involvement of the MMPs, cytokines and growths factors. UV light could be the initial trigger that activates epithelial cells at or near the limbus to produce cytokines such as IL-6 and IL-8 and growth factors. These multifactorial proteins set up a cascade of events that include inflammation, proliferation, angiogenesis and antiapoptosis. Cytokines are able to induce the expression of MMPs and their tissue inhibitors (TIMPs) making it likely that they would also affect the rate of tissue remodeling, such as destruction of Bowman's membrane and the invasion of pterygium. In the etiology of pterygium abnormalities in tear functions have also been emphasized.
Vanathi, M; Sen, Seema; Panda, Anita; Dada, Tanuj; Behera, Geeta; Khokhar, Sudharshan
To report the unusual association of unilateral congenital corneal keloid with anterior-segment mesenchymal dysgenesis and bilateral subluxated lens. A 20-year old man presented with a mass lesion involving the left cornea. The corneal lesion had been present since birth. On biomicroscopic examination, a well-defined vascularized, grayish-white mass occupying the whole of the left cornea was seen. The right eye showed multiple peripheral corneal opacities with iridocorneal adhesions, a poorly defined supranasal limbus, and a subluxated lens. Excision biopsy of the mass was done for histopathologic examination. Histopathologic examination of the excised corneal mass showed features consistent with that of a corneal keloid: thickened keratinized epithelium, absent Bowman membrane layer, and fibrovascular hyperplasia composed of hyalinized collagen fibers with irregular orientation of the collagen lamellae. During penetrating keratoplasty of the left eye, an anomalous iris pattern with poorly defined angle and a supranasal subluxated lens was also observed. Extraction of the subluxated lens was also done. The graft failed subsequent to a nonhealing persistent epithelial defect. Our case report highlights the rare association of a unilateral congenital corneal keloid with anterior-segment mesenchymal dysgenesis and bilateral subluxated lens.
Full Text Available AIM:To evaluate the changes of corneal high-order aberration(including Coma, Spab, RMShafter laser in situ keratomileusis(LASIKwith femtosecond laser, sub-Bowman keratomileusis(SBKand laser epithelial keratomileusis(LASEK.METHODS: Of 82 myopic patients(164 eyes, 31 patients(62 eyeswere treated by FS-LASIK, 31 patients(62 eyeswere treated by SBK, 20 patients(40 eyeswere treated by LASEK. Sirius system was used for measuring the coma aberration, spherical aberration, and high order aberration at 1, 15d,1, 3mo after surgery.RESULTS: 1Vision: The uncorrected visual acuity of the three groups had no differences(P>0.05. 2Corneal aberrations: Three kinds of surgical procedure for patients with corneal aberration had significant impact. The C7, C8, C12 and RMSh of three groups were increased significantly(P0.05. The C7, C8, C12 and RMSh were not recovered to preoperative levels after 3mo. But the increase of patients after FS-LASIK was smaller than the other two groups, with statistical significance(P0.05.CONCLUSION: Compared with SBK and LASEK,FS-LASIK has better visual acuity in the early postoperative and corneal higher-order aberrations increase is relatively small.
Asao, Rin; Seki, Takuto; Takagi, Miyuki; Yamada, Hiroyuki; Kodama, Fumiko; Hosoe-Nagai, Yoshiko; Tanaka, Eriko; Trejo, Juan Alejandro Oliva; Yamamoto-Nonaka, Kanae; Sasaki, Yu; Hidaka, Teruo; Ueno, Takashi; Yanagita, Motoko; Suzuki, Yusuke; Tomino, Yasuhiko; Asanuma, Katsuhiko
Rac1, a Rho family member, is ubiquitously expressed and participates in various biological processes. Rac1 expression is induced early in podocyte injury, but its role in repair is unclear. To investigate the role of Rac1 expression in podocytes under pathological conditions, we used podocyte-specific Rac1 conditional knock-out (cKO) mice administered adriamycin (ADR), which causes nephrosis and glomerulosclerosis. Larger areas of detached podocytes, more adhesion of the GBM to Bowman's capsule, and a higher ratio of sclerotic glomeruli were observed in Rac1 cKO mice than in control mice, whereas no differences were observed in glomerular podocyte numbers in both groups after ADR treatment. The mammalian target of rapamycin (mTOR) pathway, which regulates the cell size, was more strongly suppressed in the podocytes of Rac1 cKO mice than in those of control mice under pathological conditions. In accordance with this result, the volumes of podocytes in Rac1 cKO mice were significantly reduced compared with those of control mice. Experiments using in vitro ADR-administered Rac1 knockdown podocytes also supported that a reduction in Rac1 suppressed mTOR activity in injured podocytes. Taken together, these data indicate that Rac1-associated mTOR activation in podocytes plays an important role in preventing the kidneys from developing glomerulosclerosis.
Wang, Yimin; Bowman, Joel M
We present a theory of mode-specific tunneling that makes use of the general tunneling path along the imaginary-frequency normal mode of the saddle point, Qim, and the associated relaxed potential, V(Qim) [Y. Wang and J. M. Bowman, J. Chem. Phys. 129, 121103 (2008)]. The novel aspect of the theory is the projection of the normal modes of a minimum onto the Qim path and the determination of turning points on V(Qim). From that projection, the change in tunneling upon mode excitation can be calculated. If the projection is zero, no enhancement of tunneling is predicted. In that case vibrationally adiabatic (VA) theory could apply. However, if the projection is large then VA theory is not applicable. The approach is applied to mode-specific tunneling in full-dimensional malonaldehyde, using an accurate full-dimensional potential energy surface. Results are in semi-quantitative agreement with experiment for modes that show large enhancement of the tunneling, relative to the ground state tunneling splitting. For the six out-of-plane modes, which have zero projection on the planar Qim path, VA theory does apply, and results from that theory agree qualitatively and even semi-quantitatively with experiment. We also verify the failure of simple VA theory for modes that show large enhancement of tunneling.
Groundwater data from lysimeters and monitor wells in the vicinity of the Bowman, North Dakota, Uranium Mill Tailings Remedial Action (UMTRA) Project site indicated that there is a mechanism in the subsurface which cleans up downward-percolating fluids. It was hypothesized that clays and organic materials in the sediments sequestered hazardous constituents from infiltrating fluids. A program was designed to collect sediment cores from various locations on and around the site and to analyze the sediments to determine whether there has been a build up of hazardous constituents in any specific type of sedimentary material. Materials that concentrate the hazardous constituents would be potential candidates to be used in constructed geochemical barriers. The water quality of the groundwater contained within the sedimentary section indicates that there is a transport of contaminants down through the sediments and that these contaminants are removed from solution by the iron-bearing minerals in the organic-rich lignite beds. The data gathered during the course of this investigation indicate that the lignite ashing operations have added very little of the hazardous constituents of concern--arsenic, chromium, molybdenum, selenium, or uranium--to the sediments beneath the UMTRA Project site. At both locations, the hazardous constituents are concentrated in the upper most lignite bed. These data offer a natural analog for laboratory tests in which sphagnum peat was used to sequester hazardous constituents. Constructed geochemical barriers are a viable mechanism for the clean-up of the majority of hazardous constituents from uranium mill tailings in groundwater
Matthew R. Bald
Full Text Available Purpose. To evaluate Fourier-domain optical coherence tomography (FD-OCT as an adjunct to traditional slit lamp examination of donor corneas with suspected Anterior Stromal Opacities. Methods. Seven corneas suspected of having anterior stromal opacities by slit lamp examination were evaluated with FD-OCT. Each cornea was evaluated to confirm the presence of opacity and, if present, the depth of opacity was measured. Results. The opacity depth ranged from 82 μm to 624 μm. The initial slit lamp impressions of five of the seven corneas were confirmed by OCT. In two corneas, the OCT findings were different from the initial slit lamp impressions. Slit lamp examination of the first cornea gave the impression of anterior stromal scarring, but OCT showed that the opacity was limited to the epithelium. Slit lamp examination of the second cornea suggested opacity limited to the epithelium, but OCT identified significant sub-Bowman's scarring. In all cases, the Eye Bank Technicians reported that the location and depth of corneal opacity were more sharply defined by OCT than by slit lamp. Conclusion. The high resolution of OCT makes it easier to determine the location of corneal opacities compared to slit lamp examinations. This enhanced visualization can improve decisions regarding transplant suitability of donor corneas.
Chen, Yumay; Chiang, Huai-Chin; Litchfield, Patricia; Pena, Michelle; Juang, Charity; Riley, Daniel J
Neks, mammalian orthologs of the fungal protein kinase never-in-mitosis A, have been implicated in the pathogenesis of polycystic kidney disease. Among them, Nek1 is the primary protein inactivated in kat2J mouse models of PKD. We report the expression pattern of Nek1 and characterize the renal cysts that develop in kat2J mice. Nek1 is detectable in all murine tissues but its expression in wild type and kat2J heterozygous kidneys decrease as the kidneys mature, especially in tubular epithelial cells. In the embryonic kidney, Nek1 expression is most prominent in cells that will become podocytes and proximal tubules. Kidney development in kat2J homozygous mice is aberrant early, before the appearance of gross cysts: developing cortical zones are thin, populated by immature glomeruli, and characterized by excessive apoptosis of several cell types. Cysts in kat2J homozygous mice form postnatally in Bowman's space as well as different tubular subtypes. Late in life, kat2J heterozygous mice form renal cysts and the cells lining these cysts lack staining for Nek1. The primary cilia of cells lining cysts in kat2J homozygous mice are morphologically diverse: in some cells they are unusually long and in others there are multiple cilia of varying lengths. Our studies indicate that Nek1 deficiency leads to disordered kidney maturation, and cysts throughout the nephron.
Tan, Yung-Chie; Wong, Mui-Yun; Ho, Chai-Ling
Basal stem rot is one of the major diseases of oil palm (Elaies guineensis Jacq.) caused by pathogenic Ganoderma species. Trichoderma and mycorrhizae were proposed to be able to reduce the disease severity. However, their roles in improving oil palm defence system by possibly inducing defence-related genes in the host are not well characterized. To better understand that, transcript profiles of eleven putative defence-related cDNAs in the roots of oil palm inoculated with Trichoderma harzianum T32 and mycorrhizae at different time points were studied. Transcripts encoding putative Bowman-Birk protease inhibitor (EgBBI2) and defensin (EgDFS) increased more than 2 fold in mycorrhizae-treated roots at 6 weeks post inoculation (wpi) compared to those in controls. Transcripts encoding putative dehydrin (EgDHN), glycine-rich RNA binding protein (EgGRRBP), isoflavone reductase (EgIFR), type 2 ribosome inactivating protein (EgT2RIP), and EgDFS increased in the oil palm roots treated with T. harzianum at 6 and/or 12 wpi compared to those in the controls. Some of these genes were also expressed in oil palm roots treated with Ganoderma boninense. This study provides an insight of some defence-related genes induced by Trichoderma and mycorrhizae, and their roles as potential agents to boost the plant defence system. Copyright © 2015 Elsevier Masson SAS. All rights reserved.
Bassompierre, Marc; Nielsen, Henrik Hauch; Børresen, Torger
1. An elastase-like enzyme was purified from the pyloric caeca of rainbow trout by hydrophobic interaction, cation exchange and gel-filtration chromatography. 2. The approximate molecular weight of the elastase was 27 kDa and the isoelectric point was remarkably basic. 3. The pH optimum of this e......1. An elastase-like enzyme was purified from the pyloric caeca of rainbow trout by hydrophobic interaction, cation exchange and gel-filtration chromatography. 2. The approximate molecular weight of the elastase was 27 kDa and the isoelectric point was remarkably basic. 3. The pH optimum...... of this enzyme was 8.0, when assayed with Succinyl-Ala-Ala-Ala-p-Nitroanilide. 4. When assayed with Succinyl-Ala-Ala-Ala-p-Nitroanilide, the enzyme activity had a temperature optimum of 45 degree C, and the enzyme was stable up to this temperature. 5. The trout elastase exhibited a higher specific activity than...... porcine elastase against Succinyl-Ala-Ala-Ala-p-Nitroanilide and elastin-orcein. 6. The trout elastase was inhibited by elastatinal, PMSF, TPCK, SBTI and Bowman-Birk inhibitor....
Di Liberto, Giovanni; Conte, Riccardo; Ceotto, Michele
We present an investigation of vibrational features in water clusters performed by means of our recently established divide-and-conquer semiclassical approach [M. Ceotto, G. Di Liberto, and R. Conte, Phys. Rev. Lett. 119, 010401 (2017)]. This technique allows us to simulate quantum vibrational spectra of high-dimensional systems starting from full-dimensional classical trajectories and projection of the semiclassical propagator onto a set of lower dimensional subspaces. The potential energy surface employed is a many-body representation up to three-body terms, in which monomers and two-body interactions are described by the high level Wang-Huang-Braams-Bowman (WHBB) water potential, while, for three-body interactions, calculations adopt a fast permutationally invariant ab initio surface at the same level of theory of the WHBB 3-body potential. Applications range from the water dimer up to the water decamer, a system made of 84 vibrational degrees of freedom. Results are generally in agreement with previous variational estimates in the literature. This is particularly true for the bending and the high-frequency stretching motions, while estimates of modes strongly influenced by hydrogen bonding are red shifted, in a few instances even substantially, as a consequence of the dynamical and global picture provided by the semiclassical approach.
Grebić, D; Jakovac, H; Mrakovcić-Sutić, I; Tomac, J; Bulog, A; Micović, V; Radosević-Stasić, B
Environmental airborne pollution has been repeatedly shown to affect multiple aspects of brain and cardiopulmonary function, leading to cognitive and behavioral changes and to the pronounced inflammatory response in the respiratory airways. Since in the cellular defense system the important role might have stress proteins-metallothionein (MT)-I and MT-II, which are involved in sequestration and dispersal of metal ions, regulation of the biosynthesis and activities of zinc-dependent transcription factors, as well as in cellular protection from reactive oxygen species, genotoxicity and apoptosis, in this study we investigated their expression in the brain, lungs and kidney, following intermittent exposure of mice to gasoline vapor. Control groups consisted of intact mice and of those closed in the metabolic chamber and ventilated with fresh air. The data obtained by immunohistochemistry showed that gasoline inhalation markedly upregulated the MTs expression in tissues which were directly or indirectly exposed to toxic components, significantly increasing the number of MT I+II positive cells in CNS (the entorhinal cortex, ependymal cells, astroglial cells in subventricular zone and inside the brain parenchyma, subgranular and CA1-CA3 zone of the dentate gyrus in hippocampus and macrophages-like cells in perivascular spaces), in the lungs (pneumocytes type I and type II) and in the kidneys (parietal wall of Bowman capsule, proximal and distal tubules). The data point to the protective and growth-regulatory effects of MT I + II on places of injuries, induced by inhalation of gasoline vapor.
O'Malley, Kathleen G.
An iterative prototyping approach has been used in the development of requirements for a new user interface for the display workstation in the CommView system product line. This approach involves many steps, including development of the preliminary concept, validation and ranking of ideas within that concept, prototyping, evaluating, and revising. We describe in this paper the process undertaken to design and evaluate the new user interface. Staff at Abbott Northwestern Hospital, Bowman Gray/Baptist Hospital Medical Center, Duke University Medical Center, Georgetown University Medical Center and Robert Wood Johnson University Hospital participated in various aspects of the study. The subject population included radiologists, residents, technologists and staff physicians from several areas in the hospitals. Subjects participated in in-depth interviews, answered questionnaires, and performed specific tasks, to aid our development process. We feel this method has resulted in a product that will achieve a high level of customer satisfaction, developed in less time than a traditional approach. Some of the reasons we believe in the value of this approach are: • Users may not be able to describe their needs in terms that designers are expecting, leading to misinterpretation; • Users may not be able to choose between options without seeing them; • Users needs and choices evolve with experience; • Users true choices and needs may not seem logical to one not performing those tasks (i.e., the designers).
Dijkman, Henry; Smeets, Bart; van der Laak, Jeroen; Steenbergen, Eric; Wetzels, Jack
Focal segmental glomerulosclerosis (FSGS) is one of the most common patterns of glomerular injury encountered in human renal biopsies. Epithelial hyperplasia, which can be prominent in FSGS, has been attributed to dedifferentiation and proliferation of podocytes. Based on observations in a mouse model of FSGS, we pointed to the role of parietal epithelial cells (PECs). In the present study we investigated the relative role of PECs and podocytes in human idiopathic FSGS. We performed a detailed study of lesions from a patient with recurrent idiopathic FSGS by serial sectioning, marker analysis and three-dimensional reconstruction of glomeruli. We have studied the expression of markers for podocytes, PECs, mesangial cells, endothelium, and myofibroblasts. We also looked at proliferation and composition of the deposited extracellular matrix (ECM). We found that proliferating epithelial cells in FSGS lesions are negative for podocyte and macrophage markers, but stain for PEC markers. The composition of the matrix deposited by these cells is identical to Bowman's capsule. Our study demonstrates that PECs are crucially involved in the pathogenesis of FSGS lesions.
Price, D. C.; Greenhill, L. J.; Fialkov, A.; Bernardi, G.; Garsden, H.; Barsdell, B. R.; Kocz, J.; Anderson, M. M.; Bourke, S. A.; Craig, J.; Dexter, M. R.; Dowell, J.; Eastwood, M. W.; Eftekhari, T.; Ellingson, S. W.; Hallinan, G.; Hartman, J. M.; Kimberk, R.; Lazio, T. Joseph W.; Leiker, S.; MacMahon, D.; Monroe, R.; Schinzel, F.; Taylor, G. B.; Tong, E.; Werthimer, D.; Woody, D. P.
The Large-Aperture Experiment to Detect the Dark Age (LEDA) was designed to detect the predicted O(100) mK sky-averaged absorption of the Cosmic Microwave Background by Hydrogen in the neutral pre- and intergalactic medium just after the cosmological Dark Age. The spectral signature would be associated with emergence of a diffuse Lyα background from starlight during `Cosmic Dawn'. Recently, Bowman et al. (2018) have reported detection of this predicted absorption feature, with an unexpectedly large amplitude of 530 mK, centered at 78 MHz. Verification of this result by an independent experiment, such as LEDA, is pressing. In this paper, we detail design and characterization of the LEDA radiometer systems, and a first-generation pipeline that instantiates a signal path model. Sited at the Owens Valley Radio Observatory Long Wavelength Array, LEDA systems include the station correlator, five well-separated redundant dual polarization radiometers and backend electronics. The radiometers deliver a 30-85 MHz band (16 z < 34) and operate as part of the larger interferometric array, for purposes ultimately of in situ calibration. Here, we report on the LEDA system design, calibration approach, and progress in characterization as of January 2016. The LEDA systems are currently being modified to improve performance near 78 MHz in order to verify the purported absorption feature.
Amick, D.; Gelinas, R.; Kemppinen, H.; Cato, K.
A systematic search for evidence of prehistoric earthquake activity along the Atlantic Seaboard found no conclusive paleoliquefaction evidence of large prehistoric earthquakes originating outside of South Carolina. In contrast, evidence of 6 large Holocene earthquakes has been found within the epicentral area of the 1886 Charleston earthquake. These findings support the hypothesis that during the past few thousand years earthquake induced ground motions have been strongest in the meizoseismal zone of the 1886 earthquake, and are in keeping with the concept of a unique seismotectonic setting near Charleston. The return period for these rare events was determined to be approximately 500 years. It is important to note that these past studies focused exclusively on coastal areas. As a logical extension the US Nuclear Regulatory Commission is presently funding neotectonic/paleoliquefaction studies in non-coastal areas of the South Carolina-Georgia Seismic Zone (SCGSZ), the Southern Appalachian Seismic Zone (SASZ), and at several locales in New England. Within the SCGSZ present paleoliquefaction investigations have targeted: (1) fluvial deposits near Union, SC; (2) lacustrine, fluvial and marine deposits near Bowman, SC; and (3) fluvial, lacustrine and marine deposits along the Coastal Plain segment of the Savannah River. Within the SASZ, the Giles County and eastern Tennessee seismicity clusters have been identified as high priority locales for future field investigations